text:
Samsung ATIV S ReviewSamsung ATIV S 8.5
Samsung's ATIV S is a strange kind of Windows Phone device. Not because it does anything wrong, but because it really stands out from the first batch of Windows Phone 8 devices. While Nokia and HTC are trying to come up with most lively and cheerful colors, Samsung has decided to go with the strict, business kind of look with the ATIV S, resembling some of the company's old Windows Mobile devices. But can "strict" and "business" go hand-in-hand with "Windows Phone 8" – a platform which Microsoft is desperately trying to market to consumers?
The ATIV S differs from the rest in the WP8 universe with one more thing – in a typical Samsung fashion, it offers a very large display, measuring 4.8 inches. Although there are other options with pretty sizable screens, none is really that big. But the typical Windows Phone customer may turn to be different from the Android one. The ATIV S is a WP8 smartphone that can tell us if Samsung will be able to repeat the tremendous success it has seen on the market for Android devices. Let us examine!
Omnia reborn? Well, yes and no. The ATIV S reminds us of a cross between an Omnia and a Galaxy S III. While the back side has that metallic and heavy look (it's still plastic), the front is a glossy greyish plastic that doesn't necessarily match the style of the back. Still, the combination isn't that bad, and the back is downright pretty.
The Samsung ATIV S is somewhat uncomfortable to hold and operate if you want to use just one hand for that
You can compare the Samsung ATIV S with many other phones using our Size Visualization Tool.
This is one big phone. It's as big as a Galaxy S III, even a tad higher, which makes it somewhat uncomfortable to hold and operate, especially if you want to use just one hand for that. The Home key below the screen is very well made, and the same can easily be said about the other physical keys on the device. The camera key is a bit more protruding that we'd like, though, and it's second step doesn't have that reassuring click feeling.
All in all, the ATIV S has an interesting design with a hint of business style to it, which isn't something that we see too often nowadays.
As you can expect from a Samsung handset, there's a Super AMOLED display somewhere in the equation. The resolution is pretty high – 720 x 1280 pixels, which, when combined with the 4.8" size makes for a smooth 306 pixels per inch. The colors are a bit on the colder side, but just a bit. Due to the not so strong brightness levels, the screen of the ATIV S isn't very easy to see outdoors, but if you have it on maximum (or simply automatic), you shouldn't have that much of a problem to read a short message or a status update.
One of the positive sides of the AMOLED screen technology is that it has very good viewing angles, and the same is absolutely evident on the ATIV S. Basically, everything remains perfectly visible as you are widening the angle, though there's a noticeable color degradation.
Drag the picture or use the keyboard arrows to rotate the phone.
Double click or press keyboard Space to zoom in/out
93 Comments
1. TheLibertine (Posts: 484; Member since: 15 Jan 2012)
For me when it is Windows Phone it is either Nokia or nothing.
3. smallworld (Posts: 484; Member since: 13 Jul 2012)
And then Windows Phone is doomed.
57. Nadr1212 (Posts: 741; Member since: 22 Sep 2012)
That purple phone on the first page is so fat and it looks like an iPod
12. ajac09 (Posts: 1481; Member since: 30 Sep 2009)
Nokia is the reason why windows phones are doing so bad. Samsung and HTC will bring it back
14. JamesHunt (Posts: 37; Member since: 01 Oct 2012)
Like they did when nokia did not enter into WP market. Your comment does not make sense, sorry.
21. AmitMajumder (Posts: 178; Member since: 21 May 2012)
Windows Phone gained interest after Nokia entered. Their marketplace have grown much bigger after nokia started to make WP devices
48. RichieRich379 (Posts: 21; Member since: 23 Mar 2012)
I like nokia, but thats complete bull, Window Phone starting getting noticed when Microsoft decided to get serious about WP.
45. x88yunkw (Posts: 123; Member since: 20 Aug 2012)
sorry to say that htc n samsung have produced wp since years ago but nobody aware what is wp phone.
until.... lumia appear in the market.... people start to recognize what is window phone.
interesting is, human remember ' lumia ' rather than ' wp '
56. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
I agree in that I think Nokia doesn't help Windows Phone at all. Sure it's unique but most people don't want a big thick phone anymore. Thin and light with a georgeous big screen is where it's at. AKA Samsung.... and htc too
62. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
not true, there are those that want heavier phones aslong as the trade off is worth it i.e. better camera
not everyone wants thin flat slabs
77. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
Oh I know, of course some people do. That's why in my comment I said 'most'. 'Most' people do want a thin, light phone with a big flashy screen. And I think Lumias are great, but as far as appealing to the massses, I don't think it really does. I could be proven wrong, in fact I hope I am. But as of now I disagree with claims that Nokia put Windows Phone on the map.
80. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
well id disagree with you saying nokia didnt put windows on the map. just like how when people say android most think samsung when you say windows most will think lumia. sure its only starting.
second again you said ''most'' you cant say most as i could say most just want a mid range phone so none of these devices matter to them anyway
83. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
I would be interested to see the statistics, but I wouldn't have thought that most people go for mid-range. Most of the people I know get the best phone that is out there at the time. But regardless, I said that I don't think the big thick Lumias will appeal to the masses. That doesn't change even if more people go for mid-range devices.
85. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
lol so you had to take a stab at the lumia's weight, the note 2 is a heavy phone its doing just fine so weight cant be brought into it. its not a valid problem
second there are many who arent tech knoledgable and just want a all round good phone that wont break the bank and mid range phones are what they get. us on here dont make up the market. the everyday customer is someone who knows little, the basics and just want a phone to get the job done.
how can the lumia's not appeal to the masses. easy to use, stylish ( no one can say they arent good looking phones) excellent hardware, smooth and fresh. people do look for the newest different thing. it comes in colours too which can be marketed to all ages. the lumia's have as much appeal as any other high end phone
87. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
Agreed! I don't know how many times I have to say I think Lumias are good! This isn't about whether they are good or not. I think when a newbie to the market walks into a store and looks at a thin, light samsung phone with a flashy screen, they will pick that over what looks at first to be a bigger, chunkier phone. Regardless of actual goodness. I love samsung, but know all that Nokia offers, I would probably pick a Lumia as well. But a lot of what is great about Lumias aren't right on the surface. Great camera with that awesome image stabilization, Nokia Maps, Nokia Drive, exc. But those aren't things that these less knowledgeable people we're talking about would know.
70. ajac09 (Posts: 1481; Member since: 30 Sep 2009)
46 people that must be from finland hahaha
75. juusitu (Posts: 4; Member since: 03 Sep 2012)
It's just BECAUSE of Lumia 920 everybody has starting interested for WP. With only Samsung and HTC it would NEVER have become popular OS. Get the facts, you are only make laughing matter of yourself, stupid kid!!
74. juusitu (Posts: 4; Member since: 03 Sep 2012)
It's just BECAUSE of Lumia 920 everybody has starting interested for WP. With only Samsung and HTC it would NEVER have become populas OS. Get the facts, you are only make foolstupid kid!!!
82. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
I'm sorry, I'm not sure if you're referring to me as the stupid kid that doesn't know the facts, but I can see that you are both big Nokia fans, which is great. And its fine we can both have different opinions. I don't think Lumia phones are good enough to have single-handedly put Windows Phone on the map. I believe that improvements that came to the OS with Windows Phone 8 is what got people interested, and Nokia happened to come in around that time. Saying that HTC and Samsung would never help the OS get popular is purely false. HTC and Samsung (mostly Samsung) have built a huge name for themselves on Android, so people like and trust those manufacturers as much if not more than Nokia.
84. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
see obviously i can say your an android if not samsung fan, thing is the everyday average person wont really have much knowledge on wp8 as a whole but will instead connect the os to a manufacture.
like android = samsung the first thing people will think when you say wp8 is lumia or nokia. not saying the improvements didnt help but nokia have to be given credit for giving wp8 traction.
besides even though nokia's not in the greatest position most people still know the name and alot see nokia to mean excellent build quality
nokia should become what samsung is to android
86. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
Okay, I see what you're saying. When I think of Android I don't think of Samsung, I think of the OS. But maybe you're right and most less techy people would do that. And don't get me wrong I like Nokia! I'm very glad they're doing well so far on Windows Phone (I think). I hope it saves there company. My main point was just that I don't think they saved Windows Phone. I think they helped it. This is again my opinion, not claiming it to be fact. But I see where you're coming from.
89. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
i never said nokia saved windows, just there the driving force to bring it to the market and will (if they do it right) be associated and the first thing the average customer thinks when considering a wp8 device
what saved windows phone is the os itself, if it hadnt evolved then no amount of marketing or great device could have saved it. so i get what you mean and wp8 on its own should be given the credit it deserves
90. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
27. AnTuTu (Posts: 1580; Member since: 14 Oct 2012)
I know why you didn't mention Samsung here. Because you are A 4 Apple :)
59. bvalde09 (Posts: 181; Member since: 22 Nov 2011)
Mmm Nokia its fine but I think Samsung Ativ S is a monster
78. yajia1 (Posts: 151; Member since: 22 Aug 2012)
WP did not start getting famous because of lumia. It is because Microsoft became more serious with the OS and created WP8. Stupid people. I don't even see anyone with lumia 900/800 anywhere and I travel a lot. Everybody either has Galaxy SIII or iPhone 4/4s
81. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
you should look harder then, i hardly see anyone with a gs3. seen more notes then them
and lumia 800/900 ive seen many of, dont try to invalidate an entire os by claiming you havent seen them
88. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
Saying that you hardly see anyone with the gs3 doesn't mean anything. Because in pure sales numbers you can see that gs3 was the most successful Android phone ever; it sold over 30 million. Nokia phones, while I think they're very good, have no such numbers.
91. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
maybe but all im saying is just because you dont see them day to day doesnt mean there not out there
if your going on sales, look how many iphone 5's were sold...i still havent seen one person with one
people who write comments like that are only doing it to invalidate an opposing choice to there proffered os and it gets boring
92. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
How can you accuse me of trying to invalidate an opposing choice? I have done nothing even close to that. If you think saying that the Lumia is a great phone over and over and saying I would choose Lumia over other phones is invalidating it then you need to touch up on your vocabulary.
93. CellularNinja (Posts: 306; Member since: 27 Sep 2011)
I haven't even barely mentioned android! This discussion is about whether Lumia put Windows phones on the map or not. I have not tried to convince you that a different OS is better.
94. chaoticrazor (Posts: 2347; Member since: 28 Aug 2012)
no i ment the original comment not your comments was trying to invalidate
and touch up my vocabulary , no mate i dont im fine as i am thanks go talk down to someone else
2. smallworld (Posts: 484; Member since: 13 Jul 2012)
So 8 for the HTC 8X, 8.5 for the ATIV S and 9 for the Lumia 920 ?
Phonearena is so predictable.
16. Nathan_ingx (Posts: 3791; Member since: 07 Mar 2012)
It's this 8 for the 8X
8.5 for ATIV S
9 for the 820
And 9.5 for the 920!! XD
32. smallworld (Posts: 484; Member since: 13 Jul 2012)
It's impossible for the 820 to have 9. More like 7.5-8.5
34. Nathan_ingx (Posts: 3791; Member since: 07 Mar 2012)
What a small-world!!! Sometimes it's better just to enjoy the joke and not comment something silly!!
76. smallworld (Posts: 484; Member since: 13 Jul 2012)
Once again I was right.
41. Adithya7184 (Posts: 317; Member since: 05 Mar 2011)
so true...according to phonearena ativ S's camera and call quality is poor....and then why the hell is gsmarena mentioned it as Excellent...
73. g2a5b0e (Posts: 3724; Member since: 08 Jun 2012)
You called it.
79. yajia1 (Posts: 151; Member since: 22 Aug 2012)
you nailed it!
4. bayhuy (Posts: 320; Member since: 23 Jun 2011)
The only real Windows 8 phones are HTC's and Nokia.
5. Aeires (unregistered)
It's an average sized phone, what's the problem with the size? Note is large, iPhone is small, this is average, don't see why that is a negative.
7. RiseAgainst94 (Posts: 281; Member since: 03 Mar 2012)
I agree with you, the Samsung Galaxy S III did not get any cons for being too large though it is exactly the same size (.02 mm inches shorter -.-), I would, rather, place the GS III and Ativ S in a medium-large category. I think 4'3 and 4'5 is medium sized phone (normally), the Note is just a monster.
42. Adithya7184 (Posts: 317; Member since: 05 Mar 2011)
and also 920 is 10.7mm x 8x is 10.1mm x Ativ S is 8.7mm
so in this comparison ss is winner...why it is not mentiond in this review....
6. RiseAgainst94 (Posts: 281; Member since: 03 Mar 2012)
The Lumia 920 and now Ativ S have both gotten remarks regarding lack of detail in photos. I hope this is not software based (Windows 8 processing) that's pulling a Sony with their point and shoot models (loss and smudging of detail to look better at higher isos). Time will tell.
8. darac (Posts: 2156; Member since: 17 Oct 2011)
How is this too big compared to 8X and 920?
It's almost the same footprint, yet much thinner and a much bigger display.
Add to that the large battery, expandable storage and you get the best WP8 phone
9. Kronic (banned) (Posts: 321; Member since: 11 Sep 2012)
Ignore this review and wait for lumia 920
38. flexile (Posts: 78; Member since: 03 Jun 2012)
Can't agree more with you. It will be hard to get into Nokia's territory.
10. josephnero (Posts: 555; Member since: 16 Nov 2011)
its reviewed by Ray S.thats why its considered big.
11. Leo_MC (Posts: 1508; Member since: 02 Dec 2011)
Metal painted plastic?
No, thanks, we all know how quickly the paint wears off.
13. Nikolas.Oliver (banned) (Posts: 1574; Member since: 01 Jul 2012)
The galaxy s iii should have been looked like this
31. ricky71153 (Posts: 1; Member since: 30 Oct 2012)
I feel the same way!!!
15. JamesHunt (Posts: 37; Member since: 01 Oct 2012)
Yesterday i watched the Lumia 920 review. Some canadian guy was the first person to receive his lumia from Rogers. Great phone ,to say the least!! I m excited about it !
26. Nathan_ingx (Posts: 3791; Member since: 07 Mar 2012)
Watching it!! Just too beautiful!!!!
51. raunak (Posts: 507; Member since: 12 Oct 2011)
can you provide the link?
17. pyradark (Posts: 857; Member since: 10 Jun 2012)
Hoping for a sony wp. X1 is there best wp yet
23. -box- (Posts: 3991; Member since: 04 Jan 2012)
That's a WM, not a WP, but yes, Sony hardware with WP would be excellent. Really the only company I imagine not making WPs is Motorola, since they're owned by Google.
18. raunak (Posts: 507; Member since: 12 Oct 2011)
@jameshunt can you provide the link?
19. twens (Posts: 978; Member since: 25 Feb 2012)
Not that I hate wp8 but must all windows phone have almost same specs? I guess they all ran same with same speed? That must be boring,there won't be any much difference between a lumia 920,HTC 8x or ativ from Samsung.most difference will be from camera finish. Till there can be a difference in windows phones like the way Samsung is killing it with android I will pass all the time.
24. -box- (Posts: 3991; Member since: 04 Jan 2012)
There is something to be said for consistency. Android phones have similar consistencies, and some use the same hardware as the new WP8s. Makes costs lower, development easier, and reduces chances for possible fragmentation.
Samsung ATIV SOS: Windows Phone 8.1 8
view full specs
|4.8 inches, 720 x 1280 pixels (306 ppi) Super AMOLED
|8 megapixels
Qualcomm Snapdragon S4 Plus, Dual-core, 1500 MHz, Krait processor
|5.40 x 2.78 x 0.34 inches
(137.2 x 70.5 x 8.7 mm)
4.76 oz (135 g)
|2300 mAh, 13 hours talk time


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on March 9, 2013 - 11:15 PM
Oct. 12, 1929 – March 6, 2013
Robert A. Hayman, of Williamsville, a former electrical engineer and business owner, died Wednesday in Hospice Care at Millard Fillmore Suburban Hospital. He was 83.
A graduate of Buffalo Technical High School, he served in the Army Signal Corps before earning both his bachelor's and master's degrees from the University of Buffalo.
After working for 19 years at Cornell Aeronautical Laboratories, he spent the next 20 years working for a number of companies, mostly defense contractors in Western New York, New Jersey and Long Island, before returning to Amherst to start Business Information & Development Services with his son, David.
A lifelong member of Temple Beth Tzedek and the Jewish War Veterans, Mr. Hayman also served his community as a member and past master of Perseverance Masonic Lodge, where every summer he took children from the Crippled Children's Guild on an outing to Fantasy Island, and every year stood on Delaware Avenue selling The Buffalo News on Kids Day.
As a longtime member of the Western New York Science Congress, Mr. Hayman encouraged students in their studies and hobbies of science. He also served as an election inspector for nearly 20 years.
He is survived by his wife, Arlene; two sons, David I. and Michael R.; and a daughter, Susan H. Kruchten.
A funeral service will be held 11 a.m. today in Amherst Memorial Chapel, 281 Dodge Road, Getzville, with burial in Elmlawn Cemetery, Town of Tonawanda.

subset: commoncrawl


text: | Class of value Manipulation | First Second Third ===============================+================================ Pass value as a parameter | yes yes no Return value from a procedure | yes no no Assign value into a variable | yes no noI think all attempts to define other classes that the FirstClass are bound to fail, because different things that you can't do depend on the language paradigm. FirstClass depicts something relatively clear-cut in every paradigm: the full-fledged ability to be a value. -- PanuKalliokoski


text:
The following comments are in response to citizens coming before the Tucker County Commission to voice concerns regarding EMS.
The trivial word "gobbledygook" came to mind. Where are the facts of this situation or is the lack of needed clarity of information, vagueness and innuendo implied, sufficient to draw an incorrect conclusion about the management of Tucker County EMS? What is the purpose of using the words "not right" without providing the necessary information to support your claim? Mr. Luzier reported that his daughter was transported via ambulance and was distressed to learn of employee reprimands resulting from the incident.
However, Mr. Luzier did not elaborate on the reasons behind the reprimands but he believed the way the situation was handled by members of the TCAA Board was "not right" or he has a gut feeling that something is not kosher about their actions without mentioning any specifics.
Then, Mr. Luzier, why don't you tell the Tucker County citizens what specifically was "not right" about the actions taken by the TCAA Board in regard to this incident? Why don't you elaborate on what you are seeing and hearing to make your case convincing with the citizens of Tucker County concerning this issue? Is this just a case of "mud-slinging" and in making baseless charges in the hope that something sticks because you have a hidden agenda to reverse personnel actions already taken by TCAA in bringing up any unsubstantiated charges which may help your cause?
There is a TCAA operational manual and employee handbook for the clear guidance on how to operate an effective organization in providing the best possible EMS service for the citizens of Tucker County. When actions by all personnel are in full compliance with this guidance, then the efficiency of operations is greatly improved. It takes all employees and management working together in harmony to overcome any potential hurdles in services provided. Don't let hidden agendas and self-serving actions by the disgruntled distract you from your primary objective. Thank you.
David B. Currance


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Smick is a mix of smooth and slick. the word smick describes anything which is cool. The word has evolved from the use of describing men and women whom think they are slick into a word to now describe or exclaim a cool thing.
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Trending Now
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a smick is sum wee lad hu wears fake burberry caps , ben serman pair of jeans, brown shoes a bergaus or a peter storm (PETER SMICK COAT) r both!!! hav a blu bag wif blu drink n hink dey r hard as nails dey wear al gay chains n braclets n fink dey r al mad!! dey usually say " il gna get wapped out liek" but put it dis way id rater a smick dan a spice boi any dat llf dey r a disgrace
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by big balls frm da falls April 06, 2005


text:
First punk show I was supposed to go to was Circle Jerks at the Mab in SF when I was 14. But I was grounded and couldn't go. Ugh..
February 06, 2011
February 04, 2011
Team Erik og Kriss - 21 guns
February 01, 2011
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January 31, 2011
Aaron Cometbus went to China with Green Day last year. He's dedicated an entire issue of his Cometbus zine to the experience called In China with Green Day.
January 30, 2011
Melissa Etheridge Talks 'American Idiot'


text:
32124 25th Avenue S
Federal Way, Washington, 98003-6014, US
Phone: 253/529-4000
Fax: 253/529-3555
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text:
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text:
Accessories Needed
Possible Substitutions
Parts List
Regularly Purchased Together
Easy RC: Cars & Trucks
Browse Tamiya
Product Feature Page
Chassis: Ladder type, steel channel and resin cross members
Drive: Four wheel shaft
Motor: 540 size
Bushings and Ball Bearings
Shocks: Four, friction type aluminum bodies, tension can be adjusted
with separately available friction grease
Gearboxes: Closed
Differentials: Resin case with planetary die-cast gears
Transmission: 3-speed with slipper clutch
with slipper clutch to protect gears during tough off-road running
Body: Rigid plastic molded White in color, window set, plated plastic
bumpers, roll bar and body trim, plastic light lenses
Tires: Lug pattern 3.7" (94mm) diameter, 1.2" (32mm) wide
Wheels: 5-spoke Grayish Chrome 1.9" (48mm) diameter, 0.90" (23mm)
Bumper: Front, brushed chrome finish
Suspension: Rigid leaf type, leaf spring numbers can be altered to
for different tension adjustment
Camber Tie Rods: Non-adjustable
Caster: Adjustable, caster/toe-in refers to the angle of the front
suspension when viewed from the side of the car in relation to the
Steering: Bell-crank type with servo saver, 4-wheel steering can be
added by installing rear axle tension rod
Tamiya Hilux truck with friction shocks, 540 motor, surfboard,
molded White body, window section, body trim, decals, plastic light
lenses, tires, wheels, 16 tooth pinion gear, 54 tooth spur gear
Radio: 4-Channel with 2 Servos
Radio Batteries: (8) AA size
Speed Control: Electronic with reverse
Battery: 6-cell stick pack with standard Tamiya connector
Charger: AC/DC Timed or Peak for 6-cell battery
Misc. Items: Building and track equipment
Length: 19.4" (492mm)
Width: 8.5" (216mm)
Height: 8.7" (220mm)
Weight: 6.8lbs (3.1kg)
Gear Ratio: Low Gear 1:64.39, 2nd Gear 1:35.20, Top Gear 1:21.14
Tires: 3.7" (94mm) diameter, 1.2" (32mm) wide
Length: 17.7" (449mm)
Width: 6.5" (165mm)
Height: 5.1" (130mm)
For Replacement Ball Bearings use:
Qty. Size Location Qty. Bearing Set
7 5x11mm Gear Shaft 4 DTXC1547
4 6x12mm Gear Shaft 2 DTXC1569
6 5x11mm Final Gear 3 DTXC1547
2 5x11mm Front Wheels 1 DTXC1547
18 5x11mm Diff Housing, Rear Wheels 6 DTXC1547
2 5x11mm Steering 1 DTXC1547
2 5x8mm Steering 1 DTXC1523
The Tamiya MFC-02 Multi-Function Control Unit, TAMC1497 can be added
for many realistic sound, operation and light effects in addition
to sound from an audio device such as a CD player. Requires 4-ch
stick radio system
Tamiya replacement Bearing Set also available, TAMC1498.
Body pictured on the box is painted Dark Blue with Silver on the
rocker panel area. The following Tamiya colors are suggested;
TS-75 Champagne TAMR5075
TS-64 Dark Mica Blue TAMR5064
X-11 Chrome Silver TAMR8111
X-18 Semi Gloss Black TAMR8118
X-26 Clear Orange TAMR8126
X-27 Clear Red TAMR8127
jxs 11/23/07


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iOS - Add Push Notifications to your Apps with Windows Azure Mobile Services
- Posted: Feb 04, 2013 at 9:41PM
Right click "Save as…"
Windows Azure Mobile Services provides an easy to use API for sending notifications to your iOS apps. In this video Chris Risner demonstrates step by step how you can add Push Notifications to send alerts, toasts and sound notifications to your app. The demo includes:
Provisioning a Mobile Service
Registering your iOS app for push notifications with APNS and receiving an identification token
Uploading an APNS certificate to your Mobile Service
Storing your identification token in your Mobile Services
Sending alert notifications as Inserts occur on your Mobile Service
Get started with 10 Mobile Services for FREE and try this scenario using the step-by-step tutorials - tutorial part 1, tutorial part 2.
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Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
Inflammation is a natural and necessary function forming part of the body's defense mechanism from infection. In its beneficial capacity, it is a temporary reaction, passing as soon as the infectious threat has been eliminated. There are many cases in which inflammation does not switch itself off, or is triggered by benign events. These conditions can be acute or chronic, triggered by allergy, hereditary disease, chemical intolerance, or an overreaction to pathogens.
When inflammation goes awry it can produce discomfort, pain, loss of organ function, disability, and even death. Inflammation can affect any organ of the body and there are hundreds, possibly thousands, of inflammatory diseases. Examples include psoriasis and dermatitis (skin), hay fever and asthma (airways), conjunctivitis (eye), ulcerative colitis and Crohn's disease (the gut), multiple sclerosis (CNS), and rheumatoid arthritis (joints).
Some are allergy based (e.g., hay fever), some are clearly hereditary (e.g., cystic fibrosis), and some have no known cause (e.g., psoriasis). Some can affect the patient for decades (e.g., rheumatoid arthritis and asthma) while some can kill or maim in a matter of days (e.g., sepsis).
Some inflammatory diseases affect hundreds of millions of people (e.g., arthritis, hay-fever, and COPD) while others are ultraorphan diseases that affect only a few thousand (e.g., cystic fibrosis).
Inflammatory diseases affect different organs and thus exhibit different symptoms, however, they all share the same fundamental biochemical processes regarding the inflammatory reaction itself. These involve a well-characterized inflammatory cytokine cascade that may be triggered by various events but always progresses through common actors.
With so many diseases at stake, affecting so many people, it is no surprise that developing anti-inflammatory drugs is a top priority for the pharmaceutical industry. What is surprising is how few drugs reach their therapeutic end points.
Walk into a pharmaceutical industry conference dealing with anti-inflammatory drugs and you will be bombarded with a multitude of new and dazzling approaches from monoclonal antibodies, peptides, DNA or RNA therapy, kinase inhibitors, and even antioxidant molecules. Some, like the anti-TNF alpha antibodies, are already on the market while some, like some COX2 inhibitors, have even been withdrawn due to possible side effects. Many others are in the pipelines. Judging from this picture, one would conclude that the future is bright for the anti-inflammatory drug industry. The landscape, however, is much more complicated.
Visit your doctor or pharmacist and ask them how they treat inflammatory diseases (acute or chronic) and a very different picture emerges: by far the most common drugs given, regardless of the pathology, remain the corticosteroids (steroids). These drugs, discovered over 50 years ago, are often generic and are available in hundreds of different brands and formulations. In fact, steroids are second only to antibiotics in their ubiquitous worldwide usage. What is even more remarkable is that steroids are so popular despite their well-documented and frequent side effects. These include changes in weight, bone density, skin fragility, and the risk of cataracts. So why are steroids so popular? Simply put: they work. And here lies the crux of the problem.
If steroids did not suffer from such serious and common side effects there would be little need for an alternative treatment. While their full mechanism of action remains unknown, we do know that they suppress the inflammatory cascade by shutting down the production of a multitude of its actors.
If you imagine the inflammatory cascade as a Christmas tree in which each light bulb signifies a different inflammatory actor, steroids don't bother unscrewing one light bulb at a time. They just yank the electrical cord from its socket. The result: a very efficient and broad anti-inflammatory activity but at a terrible cost, since many of these light bulbs not only contribute to the inflammatory pathology but also play a role in other, necessary, cellular functions. In fact, steroids not only shut down your Christmas tree, they tend to shut down the fridge, TV, and microwave as well.
So ideally, if one were looking for an alternative to steroids, one would want a drug that rather than switching the whole tree off, would only dim it down. Steroids are not a dimmer. And neither are their current alternatives.
Newer drugs, like biologics (e.g., TNF alpha inhibitors) and COX-2 inhibitors (e.g., NSAIDs such as Vioxx®) try to unscrew just a single lightbulb, leaving hundreds of other inflammatory actors untouched. The results are drugs that are often not efficient (NSAIDs) or are efficient in only a limited number of cases (biologics). Furthermore, turning off a light bulb completely not only suppresses its role in inflammation, but can also eliminate its role in homeostasis since so many of these cytokines have a housekeeping role in their basal expression levels. The other current approaches seem to suffer from similar defaults.
What's the alternative, if any? The answer lies in understanding how corticosteroids work and why they work so well. Corticosteroids affect more inflammatory actors than any of the alternative therapies and they can be administered in almost every imaginable way—as a pill, an inhaler, a nasal spray, cream or injection. Furthermore, they are inexpensive to manufacture because they are synthetic. Therefore, what the market needs is something that works as well as steroids, can be administered as diversely, does not cost tens of thousands of dollars a year, and offers a better safety profile.
One solution that may prove promising is to remember that inflammation is indeed a cascade reaction. It starts with a trigger (and there are many triggers out there); then the first light bulb is lit, which lights the next one, and the next one, etc. In other words, the tree does not switch itself on at once but gradually. By focusing on one of the earliest light bulbs, a family of enzymes known as PLA2, one can dim the tree, affecting dozens of measurable inflammatory mediators but without switching them off completely and hence, avoiding the toxicity associated with steroids. A synthetic, easy-to-formulate class of drug targeting, the PLA2 family is currently in clinical studies in man.
It's still early to speculate, but if upcoming results in patients are indeed promising, it is very likely that by focusing on this unique and logical approach a real alternative to steroids may have been discovered. Walk into your local pharmacy and see for yourself how many drugs contain steroids. If PLA2 modulation is indeed a viable steroid alternative then the future looks very bright indeed.
Yuval Cohen ([email protected]
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Absorptive Muffler with Shells
Application ID: 14717
This model describes the pressure wave propagation in a muffler for an internal combustion engine. The purpose of the model is to show how to analyze both inductive and resistive damping in pressure acoustics as well as coupling the fluid to the surrounding elastic shell structure of the muffler. Finally, the eigenmodes of a pure structural problem is analyzed and the modes compared to peaks in the transmission loss.


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Serves 2 |
Prep Time 5 minutes |
Cook Time 0 minutes
2 cups Edensoy Vanillaor Edensoy Extra Vanilla
2 cups carrot juice
1 cup crushed ice
Carrot juice gives this smoothie an extra boost of fiber.
Place all ingredients in a blender and pulse several seconds. Pour into glasses and serve.
American, Beverages, Breakfast, Edensoy, Gluten-Free, Good/High Fiber, Good/High Protein, Low Fat, Low Sodium, Macrobiotic, No Sweetener Added, Vegan


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LAS VEGAS, Nev. - Few prognosticators nailed the outcome of Saturday's Division I-A state championship between perennial powerhouses Truckee and Moapa Valley.
Who would have thought the Wolverines, relatively evenly matched with their Southern counterpart on paper, would deliver the kind of thumping they did?
OK, so Keith Thomas, the play-by-play radio voice of Truckee football, might have.
Most others, however, expected a low-scoring war between two well-coached, physical football teams that traditionally pride themselves on defense. In Southern Nevada, prep analysts somehow figured the Pirates would run away with the win.
How wrong they were.
The "visiting" Wolverines ran away with the victory in convincing style, cementing the school's fourth consecutive state championship and 12th all time with a 34-10 win at Bishop Gorman High School in Las Vegas.
The final clutch performance capped a season of adversity and challenges, as the Wolverines struggled with injuries from Day 1, all while carrying the burden of one of the nation's longest winning streaks, and knowing they'd likely have to take down one of the new large schools that joined their division to achieve their goal.
Given their obstacles, every one of which they kicked out of their way, longtime Truckee coach Bob Shaffer was asked if the Wolverines overachieved this season.
"Boy, let's see," he said. "If that means that this team has no talent and ability, then I would say that's not this team at all. But I think overachieving from our standpoint would be competing as the next-to-smallest (D-IA) school in the state, and playing schools two, three, sometimes four times bigger than us - even five times bigger than us. We overachieved from that standpoint.
"But I think the biggest way we overachieved was in how we dealt with our injuries right from the beginning."
Regarding one particularly key injury, Truckee standout Graham Christian may never have felt so good and bad at the same time Saturday night.
The senior linebacker and Division IA North MVP took the field for his final high school game with a badly injured right shoulder, knowing full well the pain he would have to endure as a consequence.
After slinging a Moapa Valley ball carrier to the ground in the second half - one of his 10 solo tackles in the game, and 13 total - he walked gingerly off the field, slightly slumped over, with his arm tucked against his midsection.
Seemingly out for the count, he instead returned to the field again, and again and again. He had a state championship to help win.
"He was in a lot of pain," Shaffer said. "He would come out for a play or two and then run right back in, then hang in there as long as he could before coming out for a few plays, then go right back in as soon as he could again. He'd just bite his mouthpiece, grin and keep on going."
Amazing how a state title - or four in a row, in this case - can ease the pain.
"It's gonna require some surgery to get back to normal," Christian said after the game, adding when asked: "Oh, it was definitely worth it. This is such a great feeling."
Truckee's MVP was not the only Wolverine with aching body parts after doing battle with the Pirates. But you wouldn't know it watching the excited bunch of teens celebrate their integral part in Truckee history.
As they embraced and reveled in their feat, the anguish of losing their winning streak at 41 games - a 7-0 shocker of a loss to Fernley back on Oct. 6 - melted away in the horde of cheering fans and teammates. The ultimate prize, after all, was and always will be state.
"I think I was most impressed with the way they handled the pressure of the streak all throughout the year," Shaffer said. "The qualities of any team is not how they react after winning 41 games. It's how they react to losing that one game and their streak is over. How do they bounce back from that?
"And I think our kids responded obviously very well because we went on another little streak, and redeemed ourselves so to speak against Fernley the second time around. We defeated a very formidable opponent in Fallon, and then of course the playoff run was very characteristic of a true team effort."
Regarding the team-effort concept embraced by the Wolverines, several players said what they'll miss most about playing for Truckee is not the big wins in front of their peers. It's the daily routine and hard work that made it all possible, and being a part of the storied tradition that is Truckee football.
"I'm just gonna miss the whole journey - practice, working hard every day," said senior linebacker Julian Aguirre. "That was the most fun part."
"I'm going to miss the practices - the running, the conditioning, the hitting. Everything. I love it," said senior running back Tyler Curtis.
"I'll miss the tradition most," senior Justin Carter concluded. "Going to practice every day with the coaches. Truckee football. You're a part of a brotherhood, and being a part of that tradition is amazing."


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Kuruwita Publishes in International Journal of Statistics and Probability
Contact Chinthaka Kuruwita, Mathematics
Posted February 10, 2014
Tags Faculty Faculty Research Mathematics
Assistant Professor of Mathematics Chinthaka Kuruwita published an article, Testing Equality of Nonparametric Quantile Regression Functions, in International Journal of Statistics and Probability (vol. 3, Feb,2014). It was co-authored with Colin Gallagher, Clemson University, and K. B. Kulasekera, University of Louisville.
The article proposes a new approach for testing the equality of nonparametric quantile regression functions based on marked empirical processes. The authors develop test statistics that possess better Type I and power properties in comparison to all available procedures in the literature. An application of the method to hurricane data shows that the impact of climate change has resulted in more intense hurricanes than in the recent past.


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Matt Curry was mad initially, and no one could blame him.
Curry didn't think he'd be with the Curve for today's exhibition game against the Pirates. He's looking forward to the unique event and seeing 10,000 fans pack Peoples Natural Gas Field, but the reality is Curry did well enough with the Curve last season to warrant a promotion to Triple-A this year.
The 24-year-old first baseman went through most of spring training believing he would be with the Indianapolis club, only to find out from Pirates officials earlier this week he would have to return to Altoona because of a logjam of players in Triple-A.
"I was kind of mad at first, I'm not going to lie," Curry said Friday shortly after arriving in town from Florida. "You always have your sights set on somewhere where you finished last year, and I was hoping I was going to start [in Indianapolis].
Instead, Curry is back with the Curve, and the team is fortunate to have him. Altoona's offense didn't look particularly strong a few days ago based on early roster projections, but having Curry back along with outfielder Adalberto Santos, who hit .340 last year, it boosts the Curve's everyday lineup.
That lineup will be in action this afternoon against the Pirates, although fans will need a scorecard to keep up with all the changes as players for both teams are expected to be shuffled around. (Remember, the last time the Bucs visited Altoona for an exhibition in May of 2000, then-Pirates coach and future Curve manager Dale Sveum actually played in the game.)
Fact Box
Curve vs. Pirates
When: 2 p.m.
Where: Peoples Natural Gas Field
Tickets: The game is sold out
TV: Fox 8
Radio: ESPN Radio 1430 WVAM
Gates open: 11:30 a.m. for season-ticket holders, noon for all others
Bucs BP: The Pirates will take batting practice on the field from noon to 1 p.m., and fans will be allowed in the ballpark at that time to watch.
About the game: Expect a loosely structured contest, with Pirates and Curve players appearing on both teams. Most of the Pirates starters are expected to play about half the game.
As of a few days ago, Curry figured he would be playing in Indianapolis. And Alex Dickerson, the Florida State League Player of the Year last season, believed he would be the Curve's everyday first baseman.
Both players now have to adapt to changing roles - splitting time at first base and playing a lot of games in the outfield - and both understand the benefits of that.
"I like the outfield," said Curry, who led the Curve with 76 RBIs while hitting .285 with 11 homers last year. "I can run a little bit better than most people think for an outfielder."
Curry played some right field in junior college and said, "It's actually a little bit more relaxing for me out there. You don't have as much going on as you do at first base. ... I'm comfortable out there. It's not like you're just throwing a first baseman out there for the first time."
That won't be the case with Dickerson, either.
"I did play there pretty much all my career going into pro ball," the 22-year-old Double-A newcomer said.
Dickerson had 90 RBIs and hit .295 with 13 homers at Bradenton last season, enjoying a big year after skipping low-A ball. Curry skipped high-A to join the Curve in 2011, so both players know what it's like to have to adjust to a much higher level of play.
Both also said where they play on the field doesn't matter.
"If you're getting the ABs, that's all that really matters," Dickerson said.
Curry is back in Double-A because the Pirates have several players who can play first base at Indianapolis. It benefits both him and Dickerson to be able to show they can handle the outfield in pro ball.
"It's just going to add more dynamics to my game," Dickerson said. "I get to show what I can do in the outfield and at first base this year. I think it's going to make it a little more exciting actually."
On a given day, either Curry or Dickerson will be at first base and the other likely will be in the outfield. When the Curve play American League teams, one of the two could get a lot of at-bats as the DH.
Dickerson will try to prove himself at the more advanced level, something Curry already has done. But Curry now has to keep proving it if he wants to get up to Triple-A at some point this season.
"I really can't control where they put me," Curry said. "All I can do is just go out and be Matt Curry, be the guy that drives in runs, hits doubles, hits home runs and be that kind of guy that produces in the middle of the order and see what happens from here.
"I know I can hit here," he added. "I've just got to kind of show [the Pirates], kind of push their hand a little bit and make them jump me up."
Curry and Dickerson figure to be two of the Curve's best offensive players this season, and they're excited about getting the opportunity to start things off with today's exhibition against the Pirates.
Many minor leaguers spend a lot of time around big league players in spring training, so it's not a foreign concept to them to be playing against those caliber of players. The setting, though, will be quite different today.
"It will be cool to get to see those guys on the field with us, kind of in our environment," Curry said. "You kind of see them on TV all the time, now they're going to be right there on your home field with you."
And that's pretty cool for everyone, even if it is just an exhibition.
"That's going to be a great time to play, it's going to be a great atmosphere," Dickerson said. "It's definitely going to get you jumpstarted for the season. It becomes real the first time you step on the field and you've got fans cheering and everything. It's going to be real exciting."


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Just nine days after saying "I do" to longtime beau Dax Shepard, Kristen Bell is feeling the newlywed bliss.
"I'm still on a high," she told PEOPLE at Saturday's Frozen press junket in New York. "We actually did it. I can officially call him my husband, which is pretty awesome. Other than that, it feels exactly the same."
Engaged since 2009, Bell, 33, and Shepard, 38, quietly wed at the Beverly Hills County Clerk's Office on Oct. 17. The couple, who are parents to 7-month-old daughter Lincoln, waited to tie the knot until California legalized same-sex marriage, which happened in June.
With a healthy baby and a loving bond with her Parenthood actor husband, "Life is great," said Bell. "I couldn't be happier."
Now that the ceremony is over, their honeymoon may have to wait. The House of Lies star is busy filming the new season of the Showtime series and also promoting her new Disney animated feature Frozen, which hits theaters Nov. 27. Bell sings and voices the lead character in the movie.
Fortunately, Shepard is the film's biggest fan and loves the music.
"I would learn the songs at home and play them on my iPod while cooking dinner," said Bell. "I'd sing it and it would get out of my head, but for six weeks he'd sing 'Love is an Open Door' or 'For the First Time in Forever' in a loop."
And what's Shepard's singing voice like? "Terrible!" she revealed. "But no one is more passionate. He is all over the map key wise, but he's really invested in what he sings and that's what makes it tolerable. He's aware of it. When the dogs leave the room, he's aware!"
Kristen Bell Is 'Still on a High' After Marrying Dax Shepard


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Hollow or tubular: The centers of these canes were made of clear glass, giving them a hollow appearance. Often the clear glass was surrounded by a cogwheel.
... a collection of waste pieces ... packed into a pocket of transparant Glass ... adhesively collapsed ...
... into a tazza, paperweight, &c., at pleasure.
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Swatch TV
Illustrative 09 presented by Swatch / Highlights
ILLUSTRATIVE 09 presented by Swatch celebrates the cutting-edge works of contemporary graphic art. With more than 60 artists from all across the world, ILLUSTRATIVE brings together an inspiring cornucopia of visual contemporary culture. And presented at Illustrative in Berlin, the Swatch Young Illustrators Award rewards exceptional young talent in the fields of graphic design and illustration...have a look.


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Systemwide Events Calendar
Linguistics SeminarFebruary 12, 12:00pm - 1:15pm
Manoa Campus, St. John Auditiorium (St. John, Room 011)
Why Dragons? by: Robert Blust & Brittany Wilson, UHM Linguistics Department
Event Sponsor
Linguistics Department, Manoa Campus
More Information
Samantha Rarrick, (808) 956-8602, email@example.com, http://www.ling.hawaii.edu/tuesday-seminar-series
|Tuesday, February 12
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Linguistics Seminar
Manoa Campus, St. John Auditiorium (St. John, Room 011)
|Exam Tips and Hints
Maui Campus, The Learning Center
|Zencho Everywhere: A Brief History of Earthquake Prediction in Japan, 1855-2012
Manoa Campus, Moore Hall 319
|WRRC Seminar: Pathogens in Water: Value and Limits of Correlation with Indicator
Manoa Campus, Watanabe 420
|Growing Conscious 1.0
Manoa Campus, The Free Garden (Located behind the Art Building)
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.
Ongoing Events
- Scholarships Available!
- Lineage : A Family Tree of Printmakers
- The White Rose : nonviolent resistance against the Nazi regime
- Arts Exhibition: Ainu Treasures: A Living Tradition in Northern Japan
- Biggest Loser Challenge
- SAPFB Fall 2013 Funding Applications Available
- Picturing the Ryukyus: Images of Okinawa in Japanese Artworks from the UH Sakama
- Civil War 150 Traveling Exhibit
- Trial Team Waffle Bar


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LEWISTOWN - The Concerned Physicians and Practitioners of Mifflin and Juniata Counties, a group opposed to the Lewistown Hospital merger with Geisinger Health System, met Tuesday evening to discuss concerns in response to the merger announcement.
In an effort to preserve the community's greatest asset and largest employer, the group said it would like the hospital to consider a number of issues before moving forward with Geisinger.
This has been a problem through the entire process, the group said. Though the staff and doctors were informed that a merger would happen, they have still not received any actual information regarding the effects of a merger, the group said.
Geisinger claims that they are going to keep and increase jobs at Lewistown Hospital, but with technological updates, a number of jobs will become redundant, the group said. Though these new processes might be more efficient, they will cause a large amount of job loss in the records and financial department, the group said.
The staff and physicians were told that a number of documents, including the proposals of merger from outside entities and the letter of intention would be made available, the group said. However, these promises still remain unmet, creating suspicion and uncertainty, the group said.
Joining with an entity that sells insurance as well as billing creates a health care monopoly in the community, the group said. Geisinger can increase the cost of using other insurances at the hospital and thus people and businesses would be forced into signing with Geisinger health insurance, the group said.
Patient Displacement
A number of procedures that are available in town are being under utilized, the group said. Patients are being sent to Danville or State College to Geisinger clinics by Geisinger doctors, the group said. Many times, patients are moved from Lewistown because of the referral procedure required by Geisinger insurance, the group said.
Patient Cost
The expense of out-of-pocket copay costs are an ongoing issue right now, the group said. When Geisinger takes over, the copay amounts will escalate along with the service costs - another result of a health care monopoly, the group said.
Proxy Voting
A merger can only be approved with a majority vote from the Foundation of Lewistown Hospital, the group said. When they did the vote on the letter of intent, they did it by proxy, which is unethical, the group said. The group said it is afraid the board will try to approve the merger in the same way.
The Concerned Physicians and Practitioners of Mifflin and Juniata Counties declined to reveal its future plans, if any, in opposition to the merger.
Since October, the group has collected more than 2,000 community signatures in opposition of the merger.


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Download BrochureMS Office 2013
Whether for your personal knowledge or for your professional development, the Computer Training program provides courses to help you keep up with the latest office software. With emerging technology needs, The University of Texas at Brownsville and the Continuing Education program, is here to help you stay current and competitive in today's market.
Contact Information:Computer TrainingResaca Village1601 Price Rd. Suite EBrownsville, Texas 78520Phone:956-882-4174Phone:956-882-4160Fax:956-882-4171Office Hours:Monday - Friday8:00 a.m. - 5:00 p.m.
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ROCKFORD — Becca's Closet will host a community fashion show at 2 p.m. March 1 in the Center Court at Cherryvale Mall, 7200 Harrison Ave., No. 5.
The free show will feature donated dresses and accessories modeled by area high school girls.
For information: 815-962-4279, firstname.lastname@example.com.
Location, ST | website.com


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Top Definition
The Stannaz Cut is the haircut of a Mr Stanners. It can be created by growing ones hair to the amount wanted and not styling however flicking it to the left or right.
hew like pal what gannin on with ya hair
i have a stannaz cut mate ;)
i have a stannaz cut mate ;)
โดย Stanners23334 09 กรกฎาคม 2010
Trending Now
Can you define these popular missing words?


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Developers of DTC Genetic Testing Are...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
Imagine your life partner or your child being severely ill. What would it be worth to you if a doctor could exactly predict to which medicine your beloved would respond? And what doses should be enough to kill the fiend with the least side effects?
This idealistic situation is not science fiction. But we still have a lot of work to do to reach this stage. We need tools to identify patient's profiles. Therefore we have to understand diseases better than we do now and we have to identify biomarkers: indicators on a molecular level that provide information on the physical state of a person. Biomarkers can be used diagnostically and predictively. Personalised medicine is about predicting response to therapy. Therefore we need to perform research on biomarkers and turn them into diagnostic and predictive tests.
So… why don't we? How can anyone be opposed to such an innovation?
These were the two questions the EuropaBio Personalised Medicine Taskforce tried to answer. We organised workshops and attended conferences in which many stakeholders participated.
We experienced that stakeholders have a lot of difficulties in embracing personalised medicine in practical terms. Adjustments to their way of working are often needed. Health organisations, companies and government institutions alike, will need to rethink, recalibrate and change their standard operating procedures to allow personalised medicine approaches to be adopted by the European healthcare system.
This white paper aims to give insights in the developments and challenges regarding personalised medicines. It provides guidelines for streamlining personalised medicine developments and routes to patients.
In this chapter we describe why scientific developments and recent treatment successes have made many of us so excited about personalised medicine. These successes show the effects of replacing traditional intuitive and empirical medicine by precision medicine.
Patients diagnosed with the same disease may react very differently to the same treatment. This observation led the Canadian physiologist Sir William Osler (1849–1919) to the statement: "If it would not be about the variability among individuals medicine could well be a science and not an art". We are brought up with the idea that patients who have the same symptoms and whose course of disease follows similar patterns are likely to suffer from the same disease.
Scientific disciplines such as anatomy, developmental anatomy, physiology and biochemistry, helped us to get a better understanding of how a normal organism functions. Pathophysiology, micro and macro pathology and clinical chemistry helped to describe, classify and understand diseases.
However, few of these scientific advances led to a full understanding of the causes of diseases on a molecular, cellular or genetic basis. Today's medical text books still describe and define diseases on the basis of combinations of objective and subjective symptoms, macroscopic, microscopic, pathophysiological or biochemical findings, and the presence or absence of specific pathogenic organisms or substances. Most diseases are also classified according to the affected organ or organ system.
In consequence, patients diagnosed with the same disease are considered to suffer from the same underlying pathology. They are also expected to respond to the same treatments, although clinical experience tells us that this is only true in a limited number of situations. What is causing the symptoms on a molecular level, remains often unclear.
We have to admit that our current knowledge of disease mechanisms unfortunately has not always resulted in the development of highly effective medicines yet. The effective therapies we have, were developed intuitively or empirically, or were even discovered by chance. Examples include antibiotics, alkaloids, calcium channel blockers, immunosuppressants and cytotoxic agents.
There are many examples of medicines, which were developed on the basis of wrong assumptions, and some examples of medicines, which proved to be effective in an unexpected condition. But there are also few examples of medicines, like oral contraceptives or modern targeted medicines in oncology and rheumatology, of which the development is based on an exact understanding of the relevant mechanisms.
In reality patients diagnosed with the same disease based on the same diagnostic criteria show very different courses of the disease, and respond very differently to the same treatment. In clinical practice, doctors have no other choice than to optimize the treatment by trial and error.
We now know that these patients are probably suffering from different diseases. In other words: the diseases have a different underlying pathology. While the scientific progress in basic scientific disciplines such as anatomy, physiology and biochemistry has been substantial over the last centuries, we still have a very limited understanding of the molecular processes in diseases. We know even less about the factors, which may determine whether a person has an increased risk of developing a particular disease. Is "type-2 diabetes" a single homogeneous disease, for instance?
Over the last decades molecular research on sick and healthy cells gave new insights in cellular signalling pathways: mechanisms involving proteins and nuclear receptors, which are essential for the normal functioning of cells but under specific circumstances may lead to diseases. These discoveries have helped us to understand and classify diseases in a new way.
We have learned a lot from rare monogenetic disorders, which allow us to study the impact of specific genetic mutations on the clinical signs and symptoms of the disease.
This research allows us to gain insight in the underlying genetic alterations and the consequences of the presence and functioning of critical proteins. The answer to the question 'what causes diseases' is revealing itself little by little since we are able to decipher the genetic code of a person. There is growing evidence that specific genetic mutations involving specific signalling pathways play a significant role in disease development. The scientific discipline of epigenetics stresses the influence of life style and nutrition. Understanding the role of regulating RNA will lead to new ways of therapeutic treatments.
Phenotypically similar conditions classified as the same disease may originate from different genetic polymorphisms or mutations. Similarly, diseases affecting specific organs such as various types of cancers, or certain systemic inflammatory diseases may be triggered by a single common molecular mechanism.
Biochemical, genetic, genomic and other markers identifying such mechanisms can serve as biomarkers for specific disease mechanisms and diseases. Such biomarkers can be developed into diagnostics that are able to identify the specific mechanism involved in the disease affecting a specific patient. With our growing knowledge of such mechanisms we will be able to classify diseases based on the underlying mechanisms and pathways rather than on pathophysiology, pathology and phenomenology alone.
This new disease classification will finally support the development of medicines directly targeting specific disease mechanisms present in a patient.
Traditionally, oncology is the front runner in the field of personalised medicine. However, in the last decades there have been breakthroughs in other areas such as infectious diseases and haemostasis. Recently, a number of biomarker candidates have been discovered that link mode of action with disease pathophysiology within chronic inflammatory conditions including rheumatoid arthritis and asthma.
The clinical response rates to approved biologics for rheumatoid arthritis leave considerable space for improvement and predictability of the available treatments. Hence, there is currently a tremendous interest in identifying patient subsets that are more likely to benefit from a specific treatment.
Although the preliminary results of the targeted approach to treatment look promising, there are also some difficulties to be mentioned. Firstly, the identification of a disease mechanism does not necessarily mean that it can be addressed. Secondly, most cellular pathways are critical for healthy cells as well as diseased cells. Thirdly, cellular pathways consist of a sequence of reactions. If a specific molecular target is blocked or altered in this chain of events, bypass mechanisms may occur. These challenges require for their resolution further research.
Personalised medicine requires a fundamental change in our comprehension of diseases. Many traditional diagnoses may have to be revised. In the future we should be able to identify underlying molecular disease mechanisms more precisely, and in consequence make more effective treatment decisions. However, despite all this progress we may not succeed in identifying the underlying mechanisms for all diseases and biomarkers alone may not be sufficient to diagnose all diseases. It is inevitable that disease classifications and diagnoses will continue to require combinations of molecular and phenotypic classifications.
The right diagnosis will lead to the right treatment. Personalised medicine offers a more scientific approach to diagnosing and classifying diseases, and in consequence will lead to more effective treatment decisions for individual patients.
Click here for the next chapter in this series, where you'll learn how the search for predictive biomarkers is likely to change drug development research.
Detlef Niese, M.D., Ph.D., is head of development, external affairs at Novartis. The author of the introduction is Tim Kievits, managing director of PamGene and chair of the EuropaBio Task Force on Personalised Medicine.
EuropaBio represents 56 corporate members and 14 associate members and BIO regions, and 19 national biotechnology associations who in turn represent some 1800 small and medium sized biotech companies in Europe. Members of EuropaBio are involved in research, development, testing, manufacturing and commercialisation of biotechnology products and processes. Our corporate members have a wide range of activities: human and animal health care, diagnostics, bio-informatics, chemicals, crop protection, agriculture, food and environmental products and services.
This article first appeared as chapter 1 of a white paper published by the EuropaBio Personalised Medicine Taskforce entitled "Personalised Medicine: Status Quo and Challenges".
Detlef Niese, M.D., Ph.D., is head of development, external affairs at Novartis. The author of the introduction is Tim Kievits, managing director of PamGene and chair of the EuropaBio Task Force on Personalised Medicine.
EuropaBio represents 56 corporate members and 14 associate members and BIO regions, and 19 national biotechnology associations who in turn represent some 1800 small and medium sized biotech companies in Europe. Members of EuropaBio are involved in research, development, testing, manufacturing and commercialisation of biotechnology products and processes. Our corporate members have a wide range of activities: human and animal health care, diagnostics, bio-informatics, chemicals, crop protection, agriculture, food and environmental products and services.
This article first appeared as chapter 1 of a white paper published by the EuropaBio Personalised Medicine Taskforce entitled "Personalised Medicine: Status Quo and Challenges".
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text:
Something that will sail in the morning
King:Enough! My ship sails in the morning! I wonder whats for dinner?
por aemjrgekrbngnbrgkbhezdtg 31 de Agosto de 2009
Trending Now
Can you define these popular missing words?
Photos & Videos
Top Definition
N: Short for romantic relationship, popularized in fanfiction circles.
V: To endorse a romantic relationship.
V: To endorse a romantic relationship.
N: I see a 'ship developing between Hermione Granger and Ron Weasley.
V: I ship Ron/Hermione
V: I ship Ron/Hermione
por magwana 13 de Abril de 2003
A boat. That's all it should be. It's just a boat. People need to calm down with all this other crap; a ship is a BOAT. A big piece of metal that floats miraculously on the surface of the water, and usually holds people and/or cargo.
There is a ship in that movie. It was very large and it caught fire and people on it died.
por GPerc 26 de Fevereiro de 2014
(v.) to support or endorse a romantic paring that is not canon in the work(s) in which they appear. The shipping of couples is often the purpose of many fanfiction stories. Used for characters in anime, manga, video games, tv shows, etc.
Fangirl: I ship EdxRoy!!!!
por koipond 20 de Maio de 2010
An unrealistic relationship that you love so much but causes you so much pain and misery forcing you to scream "MY FEELS!" while sliding out of your chair because it never comes true even though it's so obvious it should.
Johnlock, Destiel, Drarry
"Drarry is my ship."
"Drarry is my ship."
por The Dino Girl 26 de Dezembro de 2012
A Vehicle designed for water transportation.
Thats a big ass ship, I hope those pirates dont come off of it and sink our ship into the sea.
por Rayven 25 de Maio de 2005
For those who read fics ships is short for realtion:ships:
which ship do you prefer?
por Jenna 18 de Junho de 2004


text:
on March 24, 2013 - 11:25 PM
A woman was charged with felony assault Sunday morning after she allegedly stabbed another woman in the face with a pair of scissors.
South District police said they arrested Teresa Dolan, 48, of South Park Avenue, about 8:15 a.m. after the incident with a 49-year-old woman in Dolan's home. Dolan was charged with second-degree assault and fourth-degree criminal possession of a weapon.
The victim suffered a laceration, police said.


text:
Volvo undercarriage parts are developed by Volvo engineers as part of a complete system for your Volvo construction equipment.
They have been subjected to the toughest tests to be able to withstand extreme stresses over and over again. Our design and choice of material guarantee superior performance. Quality always pays off in the long run!
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text:
Improving Attention and Concentration: Organic Ritalin
- When:
- Location:
- Academic Center
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- 103
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Having trouble focusing? Learn some basic principles behind attention and concentration and get the scoop on recent brain research that may change how you study.
Note: If the RSVP window below is not visible below, this session is full. Please check out our next session on Mar. 5, 2013 at 12:30 PM.
- Contact Name:
- Achievement and Learning Center
- Contact Email:
- firstname.lastname@example.com
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text:
I can personally recommend Mr. Cookston as being excellent in everything he does. You want the absolute best in the business - choose Mr. Cookston.
Wyell Grunwald
-------------- Original message --------------
From: Charles C Cookston <email@example.com>
> HP3000 Software architect.
> Charles C Cookston
> Web Navigation
> 4400 Monitor Drive
> Indianapolis, IN 46220
> [email]email@example.com[/email]
> 317-259-1426
> Extend the life of your HP3000 with new generation graphical screens
> connected real-time to your existing IMAGE database application. I can
> create real time data entry screen with tree searches, grids, point and click,
> drag and drop functionality. You dont have to throw away your system or
> spend millions of dollars to migrate.
> Maybe you need some new functionality. I can create a new sub-system that
> integrates to your current business system. I have 30 years experience with
> the HP3000. I have contracted all over the US and in several countries.
> Report writers are great, but there comes a time when you need an
> integrated, powerful and simple solution. I can write in any of the HP3000
> native languages (SPL, COBOL, FORTRAN) and I can use Microsoft .NET to
> create graphic solutions directly integrated to your HP3000.
> A majority of my projects have dealt with customer service, logistic,
> accounting and inventory control; however I am not limited to these scopes.
> Here is a list of some of my repeating projects.
> Electronic receipt of orders (EDI)
> Create an automated process to capture customers web and electronic mail
> box postings for new shipping requirements. Capture new data to an
> intermediate database where it is scrubbed and aligned to existing orders in
> client order database. Allow for automatic update of clients existing order
> schedule. Archive prior schedule for on-line reference.
> Create a dashboard to report new customer requests which can not be linked
> to existing orders.
> Electronic Cash application (EFT)
> Create a function to read multiple bank formats and post cash against open
> invoices. Match payments to invoices. All payments are expected to pay the
> entire invoice. If the amount paid leaves a positive or negative balance, the
> remaining balance will be written off and a new document will be raised for
> that balance. Various document types are used to separate the
> abnormalities. C$ and D$ are used for price variances. CF and DF are used
> for freight. CA and DA are used for the unknown.
> Foreign Currency
> Add foreign currency to clients customer management system. Allow for
> multiple currencies, each having effective exchange rates. Update price
> contracts, invoicing, cash receipts and returns to be in dual currency. Update
> financial analysis for currency option. Create functions to capture currency
> gain and loss to the General Ledger.
> Price Contracts
> Create a vehicle for maintaining price contracts. Allow for multiple effective
> contracts for a customer and product combination. Automatically price and
> route new orders based on the appropriate contract. Setup utilities to
> maintain blanket orders automatically as contracts change. Give advanced
> notice for contracts due to expire. Automatically place orders on hold when
> contract expires.
> Consigned Inventory
> Track consigned shipments from ship warehouse through final usage. Monitor
> quantity in transit and quantity at the consigned location. Automatically
> create billing as it is consumed from consignment.
> Warehouse Control
> Create a subsystem to build and document shipments. Items to ship may be
> entered or scanned. Customer orders are validated and ensured to not be on
> hold. Bar code labels, Bill of Lading, packing list and manifests are all
> generated. Clients inventory is updated. Order tallies are updated and invoice
> is cut. ASN files are generated and transmitted for those customers who
> require them.
> Purchase Requisition Control
> Create a subsystem to take the MRP requirements and manual requirements
> and pass them through an approval process. Individual approving levels were
> set up by dollar value. Once the requisition moved through the multi-level
> approval path, purchase orders were automatically cut.
> * To join/leave the list, search archives, change list settings, *
> * etc., please visit [url]http://raven.utc.edu/archives/hp3000-l.html[/url] *[/color]
* To join/leave the list, search archives, change list settings, *
* etc., please visit [url]http://raven.utc.edu/archives/hp3000-l.html[/url] *


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text:
iPhone 3G - One Week Review Of The Apple iPhone 3G Black 16 Gig Model
So last week, I stood in the hot sun for a few hours to get my hands on the new Apple iPhone 3G Black, 16 Gig model. Luckily, I live in New York City and we actually have the 3G network... well, for the most part. For last few months, I've been using the generation one iPhone and have been fairly happy with it. I don't have internet at home, so the primary gesture of my phone has become checking my GMail from the comfort of my bed (and deleting stupid spam comments posted to my site).
Since it's been a week, I thought I would share my experience thus far.
To start off with, the 3G network is clearly faster. This is most easily noticed in applications like YouTube and the downloaded Pandora.com on-demand radio. On the Edge network, watching a YouTube video was quite literally a hit or miss activity; sometimes it would work, sometimes it wouldn't. Sometimes it would play the first few seconds and then pause for several minutes waiting for the rest of the video to load. Now, on the 3G network, YouTube is literally on-demand video. You click, it plays. Now, I can kick off every morning with an upbeat song for a can-do attitude adjustment.
The internet is also much faster. To me, this is most easily seen on slow loading pages like Testosterone Nation. On the Edge network, this site was simply unusable! Just loading the homepage would take, no joke, several minutes. I would literally navigate to the page, put my iPhone down, go do something else for a few minutes (ex. Brush my teeth), and then come back. Unfortunately, clicking into sub-pages required the same cycle, Bleh!. On the 3G network, I can finally use this website to increase my fitness awareness. The page loads in 10 to 15 seconds which is worlds faster than it was before (much better than even the 200% advertised).
One of the "ooh-ahh" features that I have enjoyed is the fact that you can now download pictures from websites to your camera roll. Finally, things like Suicide Girls can be downloaded and used as desktop backgrounds. Other than desktop creation, I doubt I will have much use for this feature, but it's about time that they actually implemented it. You can also take a screen shot of the iPhone by simultaneously click both the top and bottom buttons - again, an ooh-ahh feature that is cool, but will probably be rarely used.
Ok, now let's talk reality. The 3G network is awesome; but, the 3G network is not ubiquitous - not even in here in New York City. I often find that the iPhone 3G downgrades its connection from [3G] to [E] (as denoted by the connection icon at the top of the screen). At that point, I am experiencing classic Edge network speeds (which are noticeably slower). The network itself seems to be a bit shotty. I can be standing or sitting in one place and go from full 3G bars, to zero bars, to Edge network, to no service, to full 3G bars in the space of a minute without having moved at all. Now, I know that this is not the fault of the iPhone 3G (or so I assume), but it does get very frustrating very quickly. What I can't explain is that areas that used to have good Edge [E] service, such as my bathroom, are now dead zones. Why would the network availability change depending on the device? Ideas? No. Frustrating? Very.
The network is not the only thing that gets slow - the iPhone 3G itself is slow... and crashy. In the last week, I'd say my Safari has crashed at least 10 times (one time it crashed 3 times in a row on the same website). This is more than my iPhone generation-one crashed in 6 months. And Safari is not the only crashy application; my SMS text messaging, YouTube, Camera Roll, and Pandora.com applications have all crashed on a noticeable basis. I have also found that the applications load slowly and have delayed response times. It is not uncommon for me to be able to type an SMS text message much faster than it actually gets rendered. There's nothing more frustrating than finishing a sentence and then sitting there, watching the buttons trigger for the next 10 seconds (as if a ghost were typing on my iPhone). Clicking on the SMS button and then seeing a white screen for 10 seconds before conversations are loaded is all a less-than-fun activity.
And what about the casing? The iPhone generation-one had a cool, badass, metal casing. I felt like I could abuse it and it wouldn't get hurt. The iPhone 3G, on the other hand, has a plastic backing. Who decided to OK that downgrade? The plastic does not fill me with confidence. The metal case was also solid and cool (temperature-wise) to the touch. The iPhone 3G, with its plastic backing, gets very warm with brief use and gets my palm all sweaty. This is not only gross but creates a dangerous situation where surfaces can get slippery and phones can be dropped accidentally. I miss the metal casing:
See how good the metal casing looks?
I'm also disappointed that there are no real application improvements. Yes, they added new features like the App Store (which has some cool apps that haven't found time to use), but the existing applications seem to be just on par with how they were before. I still cannot sent or receive Picture SMS messages (a huge limitation that continues to anger my friends). And Safari still has horrible caching and faulty Back-page functionality, especially when links are opened in a new window. Actually, when you factor in things like crappy response time and frequent crashing, the existing applications are working worse then they were before.
Overall, I enjoy the faster internet speed of the 3G network, but I find the Apple iPhone 3G to be more frustrating than its predecessor. The overall experience has been a downgrade. But, do I regret getting the iPhone 3G? No. As using Safari is the primary gesture of my iPhone use, the faster (albeit less dependent) browsing sill outweighs all the other features that have been poorly implemented.
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Reader Comments
Hey Ben,
I was thinking of upgrading this weekend... I'm curious, did you upgrade your old iPhone to 2.0? I'm wondering if the crashes are from the 2.0 os or the 3G
Sorry, I think I was unclear in my post. I did not upgrade the OS of the iPhone to the 2.0. I left my generation one iPhone with the original software. I have now purchased the new iPhone 3G and am using the software that came with it.
I'm hoping they make some updates to the OS soon and release an upgrade.
checking my GMail from the comfort of my bed
suuurree, thats what you are using the faster internet for in bed. :)
I don't what you're trying to insinuate.... As such, I can't argue with you ;)
There have been articles at Gizmodo and Engadget that point out that the phone reception issues to actually be the iPhone 3G's fault. It's happening worldwide on every network that has it. A huge blunder.
That sucks to hear :(
I thought the metal casing had to go due to increasing the reception for 3G?
Funny video: http://www.intomobile.com/2008/07/14/iphone-3g-isnt-plastic-zirconia-ceramic-casing.html
Although it doesn't exactly pertain to this post, I saw this image and thought this was funny. Goes well with quite a few computer guys-
While the facts are not for-sure, it is comforting to know that the case was not easily blended. That give me confidence.
Humor is never off-topic ;)
It's not just the 3G phone that experiences slow and crashing applications. I upgraded my v1 iPhone to 2.0 and I wish I could go back.
Ever since I updated it to 2.0, every native app is extremely slow and they all crash a lot. I'm talking about Address Book, Text Messaging, iPod, Safari, Google Maps, Clock!!!, you name it. Even the settings are ridiculously slow to open up.
I hope they fix these issues in 2.1. IMO, access to iPhone apps is not worth the trade-off of a much slower performing phone. I would have gladly waited until they fixed this before updating. Now, there's no going back and I've got an iMolasses. :(
Something I've come to realize lately (and your post confirms it even more) is that while Apple excels at making pretty hardware, and succesfully marketing their products, they generally can't create quality software. If you ignore the Apple fanboy zealots, and read honest reviews like yours, you find ample evidence that Apple consistently drops the ball with their software, including their firmware and OS X.
So then I wonder...who is better at writing software? Microsoft, or Apple? Tough call. I will say this, though: Microsoft has been dropping the software ball a LOT longer than Apple, and Microsoft has had more than enough time to clean up their act. I'm still waiting...
Sadly, there are fewer and fewer companies these days that know how to (or even care to) use good discipline in their product life cycle combined with well trained QA teams and usability testing. There are still some companies like that, but they seem to be few and far between anymore. Sigh...
I go the white iPhone, I like it, I am not getting as many bars on 3G, but the calls are okay. I turned off 3g reception when I am not using it to surf the web. By the way, who is that SEXY CHICA in the photo???? She is smoking HOT!
Hi ,
Where is your old iPhone ? can i find it on Ebay ?
Generally Apple has problems with x.0 software and clears it up with the x.1 release. As a long time Apple user, I've tried to hold off the x.0 releases ever since the System 6 days (yeah, *long* time Mac user!) but with the phone and some system software, we don't have that luxury.
I agree that things seem slower to launch. My wife and I bought our iPhones in November - well after the original launch - and upgraded three days after the 2.0 launch so that we didn't have to suffer all the initial teething problems with the upgrade delivery! I'm sure it'll get fixed in 2.1. Overall, the software improvements are worthwhile (for me) and having access to (new) applications is a good trade off.
If I upgrade to a 3G model, it won't be for six months or so.
One observation I will make - on the subject of fanboys - is that the most fervent fanboy-ism I've seen in the last few years has all come from "switchers". Long-time Apple folks are rarely fanboys :)
@Sean, re: fanboys,
Probably true. My personal definition of a fanboy is someone that loves a company or product so much, that they refuse to accept that their favorite products have flaws. And they try to hide those flaws in conversations about the products by defending the product with lame excuses. I have rarely (if ever) found you to be a fanboy, under this definition. On the contrary, in your reviews that I've read, you seem to be pretty fair. I know you have often written about your Mac OS troubles, and that is (to me) is a definite sign that you aren't a true fanboy (according to my definition). You like Apple and their products, but at the same time you are honest about their flaws.


text:
MARTINSBURG - Neither Berkeley County Schools officials nor Associate Superintendent George Michael are strangers to dealing with the issue of bullying.
Despite all that's already been done, work to refine those efforts is ongoing and probably will continue because of the changing nature of technology and cyber bullying, he said.
Since school officials know bullying happens, a form has been prepared for anyone wishing to make a complaint, although folks also can file a verbal complaint, Michael said.
Each school has a harassment complaint form available, he said.
It includes information regarding the alleged incident, what happened and when, who was involved, anyone who may have witnessed it and any reaction. The form also includes a signature space for the complainant and school principal.
By definition, bullying, harassment and/or intimidation is "an intentional gesture, or any written, verbal or physical act, or threat that is sufficiently inappropriate, severe, persistent or pervasive that it creates an intimidating, threatening, or abusive educational environment, or that a reasonable person under the circumstances should know will have the effect of: harming a student; placing a student in reasonable fear of harm to his/her person; damaging a student's property; or placing a student in reasonable fear of damage to his/her property."
This definition is evolving, thanks partially to cyber bullying, he said.
"We're not yet sure when you can bring cyber bullying into the schools, legally speaking, because this is such a fluid situation," Michael said.
"But all bullying investigations go back to the school. And I meet every fall with the assistant principals to go over all of this," he said, explaining that the harassment complaint form also includes an administrator's complaint checklist with items ranging from a description of the bullying to how the victim was harmed.
However, just because a report is filed does not always mean bullying occurred, he said.
"One of the toughest things is 'he said, she said.' But usually bullying and harassment are not one-time issues," Michael said.
Anyone can also make a complaint, even anonymously, on the West Virginia Safe Schools Helpline at 1-866-SAFEWVA or by e-mailing email@example.com.
An employee at the hotline said information reported on the hotline, which is operated by the state, goes to the local board of education and the school where the problem occurred.
Addressing bullying behavior is important because of the potentially serious nature of such incidents, Michael said.
For example, it is included in the county's student code of conduct which is distributed to all pupils as part of the student handbook.
He added that the county's student code of conduct includes possible expulsion for students who repeatedly bully and harass others - a punishment that is stricter than the state's code of conduct.
"So we send students who are repeat violators to the transitional school, because it's that serious," Michael said. "In other words, we are making it an even more serious transgression here than the state does. Our board had the power to do that and we elected to do so.
Part of the county's preventive effort is an educational DVD about bullying shown each year to students, faculty and chaperones, Michael said.
"We do take this seriously, because the emotional and mental damage can be more severe than the physical marks left behind from this type of incident," he said.
"But students and parents need to say something, we can't be mind readers," Michael said.
- Staff writer Jenni Vincent can be reached at 304-263-8931, ext. 138, or firstname.lastname@example.com