text:
Sayonara, y'all
It was hola to one old friend and sayonara to another today, as the Cubs signed minor league FA INF Scott Moore to a minor league contract with an NRI to Spring Training 2011, and placed Micah Hoffpauir on Outright Release Waivers so that he can sign a contract with the Nippon Ham Fighters (NPB Pacific League) of Sapporo, Japan, where he will be playing on the same team as Japan's #1 pitcher, RHP Yu Darvish.
With Hoffpauir being released, the Cubs now have 35 players on their MLB Reserve List (five slots open) as they continue to consider which players they will add to the 40-man roster by the 11/20 pre-Rule 5 Draft roster-filing deadline.
Since Hoffpauir is not a free-agent and is still under contract to the Cubs, a cash payment (exact amount TBD, but it could be several hundred thousand dollars) will be made to the Cubs from the Ham Fighters once Hoffpauir clears waivers on Friday and can officially sign with his new club.
I guess it's pretty obvious that Hoff will have to learn the ancient art of fighting hams, but just speaking from personal experience, I think he will find that if he approaches the ham from a 45 degree angle with a knife and fork in hand, that he will usually be able to make the cut, bite, and swallow necessary to successfully pound it down in one sitting. (At least we probably know what Hoff's family and friends should expect for Christmas this year).
Hoff-Pauir! signed with the Cubs after being selected in the 13th round of the 2002 draft out of Lamar U. in Texas. He spent six rather uneventful seasons in the Cubs farm systyem (including four seasons at AAA Iowa), before finally having a break-out year in 2008 when he hit 362/393/752 with 25 HR and 100 RBI in just 71 games (less than half a AAA season). He got occasional opportunities for MLB playing time with the Cubs 2008-10, hitting 251/312/421 with 12 HR & 48 RBI and 23 doubles in 162 big league games (exactly equivalent to one full MLB season), including a memorable five-hit game (including two HR) in September 2008 at Shea Stadium in New York. But the 30-year old Texan was unable to hit the ground running and grab the 1B job the last two months of the 2010 season after Derrek Lee was traded to Atlanta, hitting just 173/246/231 with no HR in 57 PA (24 games). Besides hitting 133 HR in 874 pro games, Hoffpauir is a very good defensive 1st baseman, winning a Rawlings AAA Gold Glove while at Iowa in 2007.
A left-handed hitter with HR power who can play 1B-2B-3B-LF plus SS in a pinch, Scott Moore comes back to the Cubs after spending the past three-plus seasons in the Baltimore Orioles organization, where he bounced back-and-forth between AAA and MLB. In 80 MLB games (202 PA) over the course of four seasons, Moore has hit a combined 223/270/370 with seven HR. Although he has certainly not had the same degree of success at the big league level, Moore would appear to profile at least as a similar type of player as Jeff Baker.
A 1st round draft pick (8th overall) of the Detroit Tigers in 2002 out of Cypress HS in California (the same HS that produced current Cubs 3B prospect Josh Vitters), Moore was originally acquired by the Cubs from the Tigers along with RHP Roberto Novoa and OF Bo Flowers for RHP Kyle Farnsworth in February 2005, and he would spend the next three seasons in the Cubs system, hitting 61 HR (combined) in 363 minor league games. Rated one of the Cubs "Top 10 Prospects" in 2007, Moore was sent to Baltimore along with RHPs Rocky Cherry and Jake Renshaw in a trade for veteran RHP Steve Trachsel in August of that season. While he has mostly struggled in his previous big league opportunities, keep in mind he is still only 27 years old (in fact today is his 27th birthday), and with a solid Spring Training, Moore has a chance to win a spot on the Cubs 2011 Opening Day 25-man roster. And if he doesn't make the cut, his versatility should come in handy at AAA Iowa, and his MLB experience could make him the natural replacement call-up if anything bad happens to a Cubs infielder next season.
Re: Sayonara, y'all
How do these type of moves come about? Not that I think the Cubs will miss Hoffpauir, but did Hendry 'actively' shop him to the Japan leagues, were they interested in him independent of Hendry, was Hoffpauir's agent orchestrating this move? Just curious how this happened in his case. Also, any insight into which pitchers may be outrighted this week based on any recent conversations you might have heard?
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Great info....thanks, Phil!
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I could dig up a link, but from a friend in Tucson and (I believe) a local newspaper or TV station, I thought it was pretty set that the (former?) Beavers would be at TEP...?
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given the sorry state of hi-corbett's facilities beyond the field (which has a wonderful view, btw) it probably is the TEP.
well, they're not in a sorry state, but it's more of a semi-pro/college/etc. type setup.
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I wish Micah the best. He should have the opportunity to make some good money there, as I can see his bat playing fairly well abroad.
Moore's a nice pickup who should be able to slide in the I-Cubs squad real well. I guess he could take Baker's spot ... but I feel much more comfortable with Baker off the bench. Moore could rotate in at 1st for Spencer, 3rd for Smith, could dabble some at 2nd for likely Tony Thomas, and might be able to dabble some in the corner OF spots. Ideally, Moore is that upper level veteran signed to fill out the minors and offer a stopgap option if the need arises.
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Bruce Levine checks in...
Hendry has had numerous meetings with representatives for free agents and has talked to other teams about trade possibilities. The Cubs and Texas Rangers were scheduled to get together to talk about possible matchups. Texas has a need for catching and the Cubs have two solid young catchers in Welington Castillo and Robinson Chirinos. Texas has an abundance of good hitting in their organization and they have excess at first base, a position where the Cubs have a need.
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imagine the haul you'd get for a guy anyone could of have had last year in the Rule 5?
Castilo might get you a B-/C+ arm at least...
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I don't know about that - I would bet that after this last season the Beanes and the Epsteins of the world are at least intrigued by Chirinos, unfortunately he's likely to be undervalued by the Cubs management.
Nice tip uv the hat to Manny Trillo there!
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Speaking of Manny Trillo, I haven't seen our Manny on here in ages.
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I've been enjoying that. Don't jinx it
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Nope, that's too much.
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If Koyie Hill is set to return, as much of the speculation suggests, I wouldn't mind flipping Castillo for say, Chris Davis, in some sort of package. That would leave Chirinos or Hill battling it out for the backup backstop job (I don't really want Hill ... but a lot of the speculation suggests that he'll be back), with the loser in AAA with Chris Robinson and maybe Clevenger if he makes it through Rule 5, with Michael Brenly in AA (and Jon Mota?).
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Chris Davis is reportedly an excellent defensive first baseman, which the Cubs have indicated is a priority for their infield.
A Davis trade would reunite him with Jaramillo, with whom Davis reportedly did not work well in Texas (which Davis subsequently denied, stating that he enjoyed working with Rudy).
Davis would be a logical move, as he is a cheap, lefty-hitting 1B with power and good D skills. He is not arb-eligible until 2012, and has even played some 3B.
His swing obviously needs a lot of refinement, and Jaramillo's endorsement of his coachability and ability to reduce the K's would likely make or break such a deal.
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Could this be Hendry actually making a decent move as a GM?
The things I've been reading about Davis make him sound pretty decent, I believe he was their guy prior to Moreland emerging...?
Anything's better than overpaying Adam-freaking-Dunn... (*ducks)
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you should duck, Chris Davis worth nothing but a minor league free agent deal and hope that he turns a couple lucky Jack Cust seasons in for you.
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LOL thanks Rob, knew I could count on you ;)
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We just let Chris Davis's equivalent sign with some Japanese league team.
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Pretty much, although Davis is younger, yes?
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Joe Ricketts talks about why he bought the Chicago Cubs:
Joe Ricketts says he only considered buying the Cubs because Tom told him that "...they sell every ticket, every game, win or lose."
Does that put pressure on them to make sure that they continue to "sell every ticket, every game, win or lose"? Something to think about and keep in mind as we go forward.
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The Cubs and Rangers match up well on several levels.
I could see the Rangers wanting Dempster, especially if they don't sign Cliff Lee.
I could see us wanting David Murphy, Derek Holland, Pedro Borbon and Chris Davis. This is not who I think we'd get in return for Dempster, but a list of young, cheap talent they have.
As for Texas, Castillo makes sense, and perhaps Marlon Byrd.
Holland is interesting. He could be used in the pen, freeing up a rotation spot for Cashner or Marshall, or be given a chance to start.
Borbon at his best, could be a leadoff center fielder, or at worst a 4th outfielder.
Davis is a project but fits the profile of what we need-a left handed, cheap first baseman that can hit for power.
Perhaps a deal of Dempster and Castillo for Holland, Borbon and Davis?
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Absolutely I'd do that if I were the Cubs. I'd even throw in a Sean Marshall for Texas' trouble.
It would signify that we were in a full on rebuilding mode though. So you have to figure that any vet would be open game from then on out this season.
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Can't be 1/2 pregnant. Although I think the term they like is "re-tool".
The Cubs are in the same boat as the Tigers were last year. Lot's of fat contracts but most will be off the books in 2012.
Get a good, well constructed team with lots of options and moveable parts and make it work. Make good use of the trading deadline and use your studs-Archer, Vitters, Jackson as mid season call-ups. Mix and stir, add some bitters and enjoy!
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Due to the free agent market being turd the last two years, a lot of teams have a lot of contracts off the books by 2012. Don't plan on buying a contender based upon that.
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Agree, but I think that's the beauty of retool/rebuild/whatever this year; the better Hendry does at assembling this year, and the better the pieces perform and fit, the less buying they have to do in the offseason next year
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I don't think you should worry too much about the free agent market when making decisions... I just want to point out that those four players listed are four guys who are likely to not get offered arbitration at some point in their careers. It's better to get one or two star level players than four "well, he deserves to be on a major league roster" types in trade.
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I'm a big fan of Holland myself, mostly dealt with injuries so far in his early career, not that those may not continue.
But great minor league numbers with flashes of major league brilliance.
Personally think a lot of teams would be all over trying to get him if he became available.
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There's an interesting trade discussion on mlb here:
It made me think of the DeRosa deal with Cleveland. This is mostly for Neal #34, but I too like Holland, and David Murphy is starting to look like a legit piece. Kinda like what the writer says in the article above, I like the idea of a couple of solid pieces instead of "one or two star level players", although you don't want the "deserves to be on a major league roster" guys either; the answer is somewhere in between.
Case in point--the Cubs were going to trade Lilly this past year, right or wrong, and Theodore probably wanted to get to a winning team.
That said, I don't think there was any huge organizational need to trade The Riot as a player; they traded him because he had priced himself out of being worth his weight through arbitration. The victory was replacing him with a somewhat-similar player (DeWitt) who doesn't hit arbitration until next year, or free agency til like 2015, and the cost was the last few months of Ted Lilly on a team that wasn't going anywhere.
Sorry, rambling...
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My point is that you don't want to fill out 20% of your roster with DeWitt's and Theriots. The goal isn't to become the most cost efficient team, it's to become the winningest team.
On Holland, his minor league #'s do look pretty good. Watching him pitch though I wonder if it as much a product of his fast promotion as it is of his talent.
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Agreed, but since the manager is the biggest part of winning, you do need a certain amount of scrappiness on your team...
(runs away laughing hysterically....)
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Ted Lilly was, and is, an excellent left handed starting pitcher. They should have gotten much more than DeWitt and a couple of third tier prospects. It was one of the few bad trades that Hendry has made.
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I don't think that there are many people who would consider Ted Lilly "excellent." He is solid, and even good.
But Hendry got a decent return for a 2-month rental of an aging pitcher.
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I really like Marshall. Just sayin'.
And there's a quote from Hendry here: http://chicago.cubs.mlb.com/news/article.jsp?...
(it's the Hoff article on mlb.com), "If there are people who fit the areas we need to address, for the most part, we'll try to keep a lot of the possibilities alive. You always hear 'so and so' might not get traded. You never know."
While that might be him implying 'I'd rather get my 1B from a trade', I kind of initially took it as 'Yes, Aram and Z are absolutely available for the right price', which made me think the rebuild is on, and personally I was completely fine with that thought.
Point Dr. Aaron, I think any vet is already open game this season.....
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Derrek Holland should be a starter. And I don't think the Rangers want to trade him.
Chris Davis has struck out almost 32% of the time in the majors. Is there a reason anyone would want Hee Seop Choi back in their lives?
and to be fair to Choi, he was far less overmatched than Davis.
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baseball reference oddity...
Chris Davis is 6 ft 3 inches in the majors and 6 ft 4 inches in the minors.
If it's a straight Davis for one of the catchers, I'd be okay with that. Sounds better than over paying LaRoche or Berkman. Choi reference and all.
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I don't see how that's better unless they fully commit to Colvin as the back-up plan. Because you'll need one...
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Maybe sign LaRoche AND flip a C for Davis as the backup plan, ie Davis is taking Hoff's spot in the organization??
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if Davis has minor league options left, sure, doesn't seem like a guy you want sitting on the bench much.
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Dammit Rob, why do you have to inject reality into my Hendry-induced hallucinations, especially when I really didn't know any better??
Don't you realize, that prevents me from having ammo later to fling at Hendry et al when my unrealistic expectations (Davis hits more HR next year at Wrigley than Dunn hits at the Smell) aren't met?!?!!?
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New TCR rule: Az Phil is no longer allowed to put any form of 'goodbye' or anything even insinuating that he's leaving in a headline...
My heart can't take it!
same Levine link as above
Hendry met with agent Barry Praver to discuss Z and Marmol. Praver says nothing about trades came up with Z and I assume they started talking about a multi-year deal for Marmol to cover some arbitration and hopefully FA years.
Re: Sayonara, y'all
Muskat tweets that NRI to spring training were given to Angel Guzman, Bobby (Free at-last) Scales, James Adduci, Scott Moore and LHP Scott Rice
(should Bobby Scales just change his name to Scott Free?)
Re: Sayonara, y'all
Rice is an interesting NRI choice, as he is an extreme groundball lefty reliever who could compete with Maine and Russell for a final spot in the pen.
As for Davis, if Hendry only has $5 million or so to spend (barring some cash that gets freed up by a trade of Fuk or Silva), then acquiring a cheap 1B like Davis via trade now would seem to make it a lot easier to find a SP and setup guy as the winter progresses.
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I think that's his motivation, and if Davis is at least serviceable, I like it.
I'm just not ready to give Hendry that much credit yet, I'm pretty sure he's going to find a way to dick it up
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Felix wins Cy Young handily.
Sabermetrics rejoices again, Murray Chass punches a wall.
bbwaa lists where writers first place votes went, kudos to them on some progress
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They had to expand ballots from 3 to 5 because someone left out Whineright and Carpenter last year; now it's 5, and someone still managed to leave off David Price. Next year, this one goes to 11.
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Wrongway still going the wrongway.
Seriously, how does Cliff Lee get a top three vote, though?
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well if you ignore he was injured in April, had a bad back in August, along with logic and reason, it makes perfect sense.
surprisingly he had the best FIP and WAR values in the AL and somehow managed 212 IP's in just 28 starts, fwiw.
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I just about nerd raged on their WAR for pitchers the other day.
Do you realize that they use DIPS to calculate their war, but totally ignore batted LD,GB,FO rates?
So FIP x IP and WAR are essentially the same thing.
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he deserved it, but wow, what a sea change in voters.
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From MLBTR:
"The Astros acquired Clint Barmes from the Rockies for Felipe Paulino, according to the team. GM Ed Wade says he pursued Barmes for his defensive versatility and gap power. The Rockies, who were not necessarily going to offer Barmes arbitration, get something in return for the 31-year-old.
Barmes was a non-tender candidate heading into his final season of arbitration eligibility. After hitting 23 homers in 2009, he hit just 8 homers this year and his batting line fell to .235/.305/.351. Barmes earned $3.33MM in 2010 and figures to pocket $4MM or so in 2011.
Paulino, 27, posted a 5.11 ERA with 8.1 K/9 and 4.5 BB/9 in 91 2/3 innings for the Astros this year. He'll be arbitration eligible for the first time this offseason (as a Super Two). In each of the past three seasons, his average fastball velocity has surpassed 95 mph. Paulino struggles against lefties, but is considerably more effective against right-handed hitters."
So, ultimately, the Stros tossed the Rox a pitcher under control with at least a chance of some upside for overpaid junk that they were going to non-tender anyway?? What am I not seeing??
Re: Sayonara, y'all
"After hitting 23 homers in 2009,"
"for Paulino, 27, posted a 5.11 ERA"
I do like Paulino's arm, but at the age of 27 you need to be able to do more than throw hard.
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Pittsburgh is looking for a SP. The Cubs pay half, take someone(s) reasonable from Pittsburgh (they've never been afraid to trade guys before), and throw in a tryout for the Steelers to convince Z to accept the trade??
No, just me?
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Z has a full no trade clause and has said he refuses to waive it, so all the rumors and speculation on where he might go is a waste of time.
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Wow. Sense of humor, anybody? Jeez.
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Z really don't get enough credit for being a bright personality and a hell of a cubs "citizen."
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...as he's punching his best friend in the face and calling out teammates in the dugout.
He is a good guy, though, he just has a short temper.
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yeah, i could take that as a reason for anyone not to like him, but he's been invisible almost his entire career compared to his teammates until recently...and recently it's been for all the wrong reasons.
J. Vazquez
says he'd love to play for Marlins, but has already received some decent offers that Marlins would at least need to approach. Definitely wants to return to NL.
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he's one of those guys that has a hard-on for specific coasts (east, in this case).
i'm sure at this point he'd go where the money and years are, but i wonder if chicago is too "west" for him.
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He did play multiple years with the White Sox, but I think I recall him bitching about spring training in AZ. I'd bet he signs with an NL team that trains in Florida.
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according to rumor stl/chc/col/was have all inquired about them.
there's probably more and there's probably a team or 2 up there that hasn't even contacted him...woo rumors.
WAS was mentioned before the season even ended as a place that would like to have him for 2011.
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I was on a crew yesterday doing audio for a cable network. Z walked in from the left field corner almost out of nowhere. Lou Cannelis got to him first (Sox fan) and then my cameraman got right in on the action while I got pretty aggressive with my boom. We then got him to ourselves while the producer asked some questions about college "football". He was mildly amused I'd say - but ours is not the kind of "football" he likes. I guess he tolerates the Bears as he says.
Gotta say it was really cool (and recording) seeing the NU kicker rattle the seats with footballs in the RF Bleachers. I never yelled out "you suck!" even!
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ESPN radio report
Big Ten says Wrigley wall too dangerous. Game will still be played. But teams will switch ends each possession on offense. Only head away from the wall.
Story up now:
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solid planning....
damn, no kicks on Sheffield
gonna be some pissed off folks who bought tickets to that side of the field
Re: NU/IL Dumbowl
Jonah L. Rosenblum writing for the Daily Northwestern pins the tail on the donkey. The layout of the field was the result of a collaboration between the "braintrusts" at NU and Illinois.
Among the primary issues were field layout and the safety of the players involved.
"When (Illinois coach Ron) Zook and I were down there over the summer a couple years ago, we both said we were for it as long as the health, safety and well-being of our players is the number one priority," coach Pat Fitzgerald said. "It got turned over to the universities, and they were the ones making the decisions."
The layout that was ultimately decided upon puts the right field wall just behind the north end zone, a potentially dangerous situation, but Fitzgerald insisted both universities were taking safety into account.
"If you think back, it took some time for the T's to get crossed and the I's to get dotted so I think both universities felt great about it from a risk management standpoint," Fitzgerald said. "It will be an element in the game but we'll plan accordingly."
The Illini and Cats will also be sharing a sideline, which is highly unusual in college football. And while Bears games were played on a north-to-south field, NU and Illinois will be playing east-to-west, which might cause difficulties as the sun begins to set.
Other issues included ticket distribution and liability, but all of these have been worked out at least for 2010. As for future games, Wolf wrote in an e-mail that Cubs Executive Chairman Tom Ricketts suggested having a game at Wrigley Field every year, but Fitzgerald doesn't want to jump the gun.
"Why don't you ask me that on Saturday?" Fitzgerald said. "It's been a lot of fun to this point. I'm just appreciative of our administration handling all the logistics."
With the majority of the game being played on top of the Cubs infield, which consists of newly dropped sod, it will be a miracle if the turf doesn't start peeling off.
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while it's easy to knock NU and the Illini, why does the Big Ten get themselves involved just a few days before?
I suppose we'll find out, but I doubt they were completely in the dark until this week on the logistics of it, it seems like they just decided this week to pay attention.
while I mocked it myself, I assume there's just a shitload of padding on the wall on that side of the field which should suffice. The coaches all joked that it would get the player ready for Arena Football and were comfortable with it.
more on the decision, Illinois guy pawning it off on Northwestern since their the home team and basically blaming a rule that no one bothered to look up that there needs to be 12 feet of distance between endzone and any barriers.
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I wrote Big Ten. But it sounds like it was a joint decision between NU, U of I, & the Big Ten.
The interview I heard said something about after seeing the field actually set up, with the padding installed, they felt safety should be their main concern.
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Didn't the Bears play there for years?
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Yes, and the field was configured the opposite direction for Bears games. One goal post was near the visitor's dugout and the other was in LF. It sounds to me that today's players and coaches are just pussies.
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and had the field going from 1b to LF, rather than 3b to RF, not sure why they decided to change it.
judging from the photo, they'd still have the same 12 foot issue at least in one corner.
-edit- also, didn't they add a few rows down each foul line for those special auction seats, which would force some changes.
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Many are asking why the field isn't laid out north south the way the Bears used to play it. But in those days the goal posts were right on the goal line and the end zone in left field was only 8 yards deep. You just can't fit a regulation field in Wrigley that way anymore.
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You are correct about the end zones being 8 feet deep at Wrigley.
As Pappa Bear use to say "Passing is for pussies."
There is a story of Bronko Nagurski scoring against the Washington Redskins at Wrigley, knocking two linebackers in opposite directions, stomping a defensive halfback and crushing a safety, then bouncing off the goalposts and Wrigley Field's brick wall. On returning to the huddle for the extra point try, he reportedly said: "That last guy hit me awfully hard."
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Sounds more like Bill Brashky ;)
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Did I ever tell you about the time Brasky went hunting? Well anyway, Brasky decides he's gonna hunt down all four members of the Banana Splits. He stalks and kills every one of them with a machete. They all beg for their lives, except Fleagul.
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10 playoff teams are a coming
probably for 2012 season, looks like 2 WC's that will play each other in 1 or 3-game set. You'll certainly play to win the division now.
Hopefully a 7-game LDS comes with it...
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and a 154 game season, so we won't have to watch game 7 of world series on thanksgiving.
/thought I go with that rather than another series for Cubs not to get a win in
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Too soon, man. Too soon.
(But yes to going back to 154)
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Dump the divisions. The first place team in each league gets a bye until finals where they meet the winner of the also-ran playoffs.
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I think a 5 game LCS would be good if they insist on all these damned off days.
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lame. very very lame...
what's the point of playing so many games only to let 1/3rd of the league into the playoffs?
might as well be hockey or pro basketball...only with twice the amount of games to play before they let almost everyone into the "playoffs."
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oh, i know why it was done...i just hate the cheapening of the playoffs by letting too many people "in the door."
just venting...wooha.
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Sayonara Larry - Yankees sign Larry Rothschild to be their pitching coach for three years
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I put up a post on it if folks wish to discuss.
Recent comments
first game for lester giving up more than 2 runs since july 24th. hell of a run.
doh, yes...dunno what happened there. jake arrieta is all "bro wut?"
lester going for #20...cubs haven't had a LH (thanks jpep for the correction) 20 game winner since d.ellsworth in 1963.
fwiw, all the games are free on mlb.tv
Short rest for MadBum would be 2 days. WC game is Wed., Games 1 & 2 are Friday/Saturday.
A left-handed one...
J-Hey not finishing with an offensive onslaught.
If Geoff Blum could be a Playoff hero, there is hope still...
Giants scare me. I think you're wrong about Bumgarner, he would pitch on short rest for Game 2 and then full rest for Game 5. Cueto would go Game 1, then short rest in game 4. Add in some really tough outs in that lineup and I want nothing to do with them. With that rotation they can easily steal a series.
Cards are a tough matchup. The rivalry evens out their comparable lack of talent. And like someone said, they love HRs, which is how to beat the Cubs. The upside is that I would feel really good about Lester twice against STL.
j.buchanan with a nice start...5ip 2h 1bb 3k, 0r/er
zobrist with 2HR and a double through 8
heyward 0-4 :(
Mark Gonzales @MDGonzales
Soler likely to return Sunday, Maddon says
Right now, I'd like to see the Mets first, Giants 2nd.
I believe that since most of the team from last years' NLCS is on the squad this year, they will really amp their game up even more to kick their ass in payback for 2015.
The Giants just do not have the depth in years past, and I think all things equal - and at Wrigley - they could handle them.
I do not want to see the Cards, period. Or their fans, media, or Joe Buck.
I don't want to play Braves in the first round. Any friggin team in the league can win 3 of 5..I hate the first round. Furthermore, I wanted to play the Marlins in 2003 and the Mets over Dodgers last year.
With that said in reverse order:
3. Cardinals: It will be devastating to lose in the first round, but even worse to their main rival. It is increased incentive for the Cardinals, especially after last year. Cards would have nothing to lose, Cubs have everything to lose.
2. Giants: Rotation in the playoffs scare me a bit, but what a lousy team.
1. Mets--because of the losses in the rotation
2. Giants--because they're not the team they were BUT they maybe have bullshit even-year magic?
3. Cardinals--because rivalry and not making the playoffs hurts them more than losing in the NLDS plus getting eliminated by them in the playoffs would make for horrible sports commentary next throughout next season.
Who's asking?
CLE/DET rained out last night already, possible rain-outs in New York (vs. Baltimore), Boston(vs. Toronto) and Philly(vs. Mets) this weekend too.
Not only games involving playoff spots that would need to be played, but any that involve home field advantage.
I got the first one! Second one I'm not even sure what even/odd betting is.


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4 Awful Things You Forget About Being Single
#2. The Inhuman Hours
As an adolescent, in the absence of an enforced schedule, I would play computer until 10 in the morning and sleep until 3 in the afternoon. I was the saddest kind of vampire: eschewing the sun-walkers not in favor of the sweet embrace of the night, but in favor of playing the modded version of Marathon where all the aliens' faces were butts. Then, in my late teens and early 20s, the only jobs I could find were night positions: waiting tables, tending bar, working graveyard shifts at gas stations. Since the only things open after my shift were bars, and since I didn't have a particularly compelling reason not to drink until my brain erased the memory of cleaning the heroin-diarrhea out of a Chevron bathroom stall, I spent most of my non-work hours either drinking or recovering from drinking. And that's why service workers are all alcoholics.
Yep. That's the story we're going with.
Truly, you are the most unsung of heroes, Hungover Movie Ticket Taker Guy.
In the shittiest kinds of service jobs, they make you work split shifts: That's when you show up and work for six hours, get two hours off, then come back and work for six more hours. In those kinds of jobs, you learn to sleep like soldiers in war movies: whenever and wherever you can get it, because you never know when the next opportunity will be. So I thought my screwed-up internal clock was born out of necessity, and had been bred out by 10 years of normalcy. But apparently my wife's 9-to-5 work schedule was the only fragile cable tethering me to the human world. Without it, I have come entirely unloosed: I get to bed at around 4 a.m. now and sleep for a few hours, then get back up and head into the office. When I get home, I might sleep for a few more hours, if it's too hot for my video card to render Borderlands without crashing -- or maybe I'll just spend the afternoon arguing with my dogs about whose turn it is to turn off the rainbows, because I'm so sleep-deprived that I have completely lost track of the line between dream and reality. For example: I'm pretty sure I hit a giant talking rabbit on my motorcycle yesterday.
Well, I say "talking," but to be fair, I only heard screaming.
Was that a dream? Or did I accidentally kill an aspiring young Method actor going out for the part of the Trix Rabbit? Hey, this is LA: It could go either way. All I can say for sure is that this is not a healthy lifestyle, and that these bloodstains are really fucking with my paint job. So if anybody knows how to get back on a human sleep schedule, or how to scrub a slurry of human teeth and fur out of the steering column of a Triumph Bonneville, please hit me up.
#1. The All-Consuming Bitterness
So we've established that my wife is The Lawgiver, and in the absence of her presence my personal life instantly dissolves into Lord of the Flies. And you know what? I'm surprisingly OK with that: I'm turning out to be pretty good at ensnaring the wild pigs that roam my apartment, and I've only had to kill two fat children with rocks so far. There were conflicts, at first, when my new, simpler, more primal lifestyle had to interface with the stodgy old outside world. Like, say I want to go get the mail: If the wife were around, I'd probably feel pretty silly walking outside in my bathrobe, then growing fearful of the whirly metal things in the sky and attacking the mailman when I got overstimulated. But now, that's just a Tuesday.
The only real problem, if I have to find one, is that I guess I accidentally got my already infinitesimal faith in humanity all tangled up together with my wife, and now that she's gone, the entire world is just a giant, sucking spiral of hatred.
That's turning out to be kind of a hassle.
And now I have to burn all life to cinders, and return the planet to innocence. You know how it be when the wife is gone.
Without somebody with a little more optimism toward our species to play devil's advocate for all the assholes in the world, I perceive every slight by my fellow man as not only intentional, but part of an overarching plan to ruin the entire universe. And there are, oh, so many slights! Because I live in LA, and LA, as you may know, has an inverse asshole ratio. Allow me to explain: Everywhere else in the civilized world, you can find about three wads of sentient dick for every 10 decent human beings. But Los Angeles is Bizarro World: The whole place is just bursting at the seams with assholes; assholes fall from the sky like raindrops; assholes cascade down the street together, absorbing everything in their path and turning it into more assholes, building asshole momentum until there's a veritable flash flood of assholes hurtling through the city, wiping out everything before it like a biblical plague.
If that sounds psychotic to you, well, congratulations on spotting the obvious. That community college psychology course is really paying dividends, huh? Obviously it's insane: But that's what single life is to me. I forgot just how goddamn crazy I was without the tempering influence of a normal, compassionate, loving human being in my day-to-day existence. Luckily, a few years ago I tricked that person into signing a contract, and now she wears a piece of metal that legally binds her to me. I have trapped my sanity and ensnared it with a ring. So if you're like me, and your natural mental state is one inconsiderate uncovered cough away from burning down a Pottery Barn, I heartily recommend you do the same.
All things considered, I'm actually glad for this newly single time, because I've learned something from it: I've learned what a good spouse truly is. A good spouse is the anchor that keeps you from being drawn inexorably into a vast, writhing ocean of douchebags and savagery.
Hey, that's pretty good; I should sell that shit to Hallmark. Maybe crochet it onto a throw pillow or something.
Buy Robert's stunning, transcendental, orgasmic science fiction novel, Rx: A Tale of Electronegativity, right here. Or buy Robert's other (pretty OK) book, Everything Is Going to Kill Everybody: The Terrifyingly Real Ways the World Wants You Dead. Follow him on Tumblr, Twitter and Facebook.
For more from Brockway, check out 5 Surprising Upsides to Getting Married and Deadliest Book Report in the History of 4th Grade.

subset: commoncrawl


text:
Source: AP on Google News
quote: Democrats, unions and other liberal supporters outspent Republicans by far. You can check the facts.
quote: The real powers that be use the "Divide and conquer" method and you two are illustrating it now.
quote: Illegal immigrants aren't allowed to vote in the US


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on November 10, 2012 - 12:31 AM
Throughout the first half of the season the importance of special teams was drilled into the UB consciousness with jackhammer force.
A 100-yard kickoff return by Georgia's Todd Gurley broke an early 7-7 tie in the season opener. Another 100-yarder by Ohio's Daz'mond Patterson ripped away the momentum of UB's early 14-0 lead. Against Pitt, the Bulls realized on average a 10-yard decline in field position on each exchange of punts. Somehow, someway, UB consistently was coming out on the short end of the special teams battle and it was costing them dearly.
What's the importance of special teams? Last week Western Michigan put away Central Michigan when it recovered a fumble on the kickoff following a touchdown and went on to score again. Ohio had two punts blocked and couldn't get two others off in Wednesday's loss to Bowling Green. And let's not forget last Saturday at UB Stadium, when Devin Campbell's long kickoff return set up Patrick Clarke's walk-off field goal after the Bulls had yielded the tying touchdown with 23 seconds left.
UB coach Jeff Quinn and his staff always have stressed special teams but the emphasis seems to have grown the last couple of weeks. On Thursday, while questions lingered about his starting quarterback, Quinn said he expects special teams will be the determining factor in this afternoon's Senior Day game against Western Michigan (4-6, 2-4). Kickoff is at 3:30 p.m. (Radio 1230 AM).
UB's special teams scored some subtle victories before last week. The Bulls neutralized UConn's dangerous returner, Nick Williams. They took Toledo's explosive Bernard Reedy out of the game. The win over Miami last Saturday was, particularly from a special teams perspective, a long time in the making and reinforced the team's commitment.
"Very proud," said linebacker Willie Moseley. "That's what we harp, we harp every day in practice and in meetings, special teams, special teams, special teams. To see it all come together and get a W out of it, that's all we can ask for."
Western Michigan hits town with a more balanced offense than Miami and with some welcomed uncertainty at quarterback. Senior Alex Carder, out since injuring a finger on his throwing hand on Sept. 22, was cleared to practice this week and figures to see at least some time leading into next week's career-finale against Eastern Michigan.
There hasn't been much if any drop off with Carder's replacement, Tyler Van Tubbergen, a 6-3, 200-pound junior. "TVT" has completed 61 percent of his throws with 15 touchdowns.
The main cog in the running game is the diminutive Dareyon Chance, who's generously listed at 5-foot-5. He's averaging 6 yards a carry in MAC games.
"They do a lot with their personnel," Quinn said. "They have over 10 different personnel groupings that they'll put on the field. You'll even see a little swinging gate. Bill Cubit's an outstanding football coach and they play hard. They're very multiple but very balanced. They're a little bit more on the ground (than Miami)."
The Bulls (2-7, 1-4) are gunning to string together consecutive wins for the first time since 2009. As always, getting the running game into gear will be one of the keys.
"We're very proud of our running backs and our quarterbacks and we want to protect them and get the ground game going, that's what we take pride in," said senior offensive tackle Gokhan Ozkan. "It's a great feeling knowing we have momentum coming into this game. I think there's an extra chip on my shoulder it just being Senior Day, my last go at UB Stadium."
Joe Licata filled in for the injured Alex Zordich at quarterback last week and managed the game well. Zordich practiced this week and it wouldn't be a surprise to see both factor into the game plan. The Bulls inserted Tony Daniel, a QB styled like Zordich, on the third series against Miami.
"I feel good about the game plan we had last week and we feel good about where we're heading with our game plan this week but I think it's still going to come down to - these kids know this - special teams," Quinn said. "It really is."
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5 Celebrities With Secretly Talented Siblings
#2. Daniel O'Brien's Brother Is a Goddamn Musical Prodigy
The Celebrity:
Yep, I'm calling Cracked's own Daniel O'Brien a celebrity. When you bring in viewers by the tens of millions on one of the highest traffic comedy websites in the world, you are a celebrity. Deal with it, Dan. For the rest of you, you know him from ... well, here. Agents of Cracked, his column, After Hours. You can find his big ol' head flopping around all over the Internet, saying comedy words at people and then rubbing his phat check in the faces of his disgusted bank tellers. Without Dan's writing, acting, and editorial input, I dare say this would not be the same website. It would probably just be a bunch of drunk guys farting into a webcam and then laughing until they vomited Jagerbombs.
The Talented Sibling:
Thomas O'Brien is Dan's older brother, and let me get this out of the way right off the bat: If he wasn't worth talking about, I wouldn't talk about him. Neither Dan nor I owe each other any favors, and even if I did, I wouldn't pay it back like this. It would be paid in whores and rides to the free clinic. Tom is truly, genuinely a musical genius. Here, see for yourself -- I'll ease you into it:
That is from a series he calls "One Take Thursday." The "one take" part of that is exactly how it sounds. He sits down at his keyboard and busts out a piece in one take ... from fucking memory. No practicing, no sheet music. Just him and a keyboard or a piano, having fun. Now, let me ramp it up a notch by showing you this:
That's Imogen Heap's "Hide and Seek," and even if you've never heard the original song, it is still amazing. He gives his music the same amount of emotion and enthusiasm that his parents did with their shame and resentment of Dan. It's a goddamn crime that he isn't doing this for a living right now. He's taught high school music, but through his own admission, there just isn't a lot of money in being able to play the piano. Not until you get up into the "playing concert halls" or "writing movie themes" rung of the ladder -- which he's already started by creating the opening theme to the aforementioned Agents of Cracked.
Surely there's someone out there in the industry who's reading this that can hook this man up. The thought of him going his whole life without utilizing that talent on a grander stage than YouTube makes me so angry, I could just grab Dan by the ear and elbow his temple over and over and over and over again. Just elbowing him so hard that he starts crying and trying to get away, but I'm all like, "You ain't goin' nowhere, funny man! You get back here and take your medicine! Your elbow medicine!"
Oh, and if you still need convincing, watch how ridiculously fast his fingers are in this piece:
#1. Art Garfunkel's Brother Shapes the Entire Computer Industry
Jo Hale/Getty Images Entertainment/Getty Image
The Celebrity:
Art Garfunkel is the "white guy 'fro"-sporting half of the legendary folk duo Simon and Garfunkel. They entered the Rock and Roll Hall of Fame in 1990, causing Art's giant 'fro to fluff with excitement. On top of its historic musical career, his enormous, monstrous 'fro is also an accomplished actor and poet.
Via Ultimateclassicrock.com
The Talented Sibling:
Remember that whole Y2K crisis that had everyone panicking in the year two thous- ohhhhh, that's what that means. Sorry, sometimes I'm a little slow picking up on acronyms. Anyway, when all that dumb bullshit went down, Jerome Garfunkel was one of the big dogs they went to for a solution. Why? Because it was mainly a problem in the COBOL programming language (heavily used in older business and financial software), and he happened to be a lifelong developer of it.
In fact, the guy knows the ins and outs of just about every nerdy language you can think of, and has been a major player in the software engineering community since software became a thing. Without him, the porn box that you're reading with your face-eyes right now would look and operate very differently. Because even when he's not doing hands-on work, he teaches scores of other programmers and software engineers what they need to know in order to make dicks and titties flop around on the screen without making your processor catch on fire.
Via Wcspeakers.com
Gaze upon its majesty and beauty.
On top of that, his own gigantic, heaving 'fro was the senior technical adviser to the U.S. Department of Commerce and the U.S. Department of the Interior. So when something technical fucks up on a grand scale, he's like the planet's IT guy. Except instead of just telling you to stop going to horse-fuck sites, he can rewrite your OS to prevent you from ever going there in the first place.
Also, he had a gargantuan 'fro.
Special thanks to Sammy Trujillo, Paige Turner, Kelly Stone, and Paul K Pickett for vital help with research! You can find all the stuff you'd ever care to know about John Cheese right here.


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October 22, 2008
The World Health Organization has warned that the global financial crisis will likely cause increased mental health problems and suicides as people cope with poverty and unemployment.
According to The Washington Post, hundreds of millions of people are already affected by mental illnesses worldwide and the current market crisis could worsen feelings of despair. Additionally, poverty and related stresses may trigger the onset of mental illness in others.
"Governments must make mental health a vital part of primary health care," said Margaret Chan, director of the World Health Organization.
CNN also reports that a new study in the American Journal of Preventive Medicine suggests that following a decade-long decrease, suicide rates in the United States have risen, largely because of an increase in middle-aged white men and women. The reason for the increase is unknown, but experts are concerned that if economic conditions continue to decline, suicides could go up.
"There is a considerable risk that the current economic situation may result in a further spike in the suicide rate for men of working age, especially if we start to see an increase in unemployment and a decrease in housing affordability and consumer sentiment," said Seetal Dodd, Ph.D., a senior fellow at the University of Melbourne in Australia.
Other factors affecting the middle-aged include caring for aging parents and coping with substance abuse or unemployment.
Strategies for People Living with Mental Illness: Ten Tips for Managing Stress
The Wall Street Journal: Angst Is Rising, but Many Must Forgo Therapy


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Drug use among top issues for Legislature
January 7, 2013
Serious attention to this state's elementary and secondary education system, and the twin problems of drug abuse and the crowded prison system that is a result of that abuse, should be some of the......
As usual, regressive propagandist Tom Miller acts as a shill for the WV Democrat establishment.
Given the recent vote fraud convictions in Lincoln County, should it not be a top priority to ensure that everybody who tries to vote actually does have the right to vote and votes only once? Not a priority for Mr. Miller.
If Ms. Marple had the interest of the State at heart, she'd do what every working guy is expected to do when he's lost a job: Look for another one. But it's all about Marple, not about WV kids. With the help of Mr. Miller.
How do people who are no longer looking for work survive? They get money from the taxpayer. If they fail drug tests chances are they'll buy more drugs with our money. But according to Mr. Miller, drug policy is more important than job creation.
Last, but not least in typical regressive fashion Mr. Miller conflates military weapons with "traditional" firearms. I'm sure he knows the difference. It just doesn't fit his agenda. How inconven
4 Agrees | 3 Disagrees | Report Abuse »
Voter fraud ...
Yeah. That's why the state is turning red on the political spectrum and we have a DINO governor.
1 Agrees | 0 Disagrees | Report Abuse »
Showing 2 of 2 comments


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She let me put pigtails in her hair yesterday. We haven't done that in a while.
She lies here next to me, asleep with her too big feet and beautiful face. I still can't get enough. I would have a thousand more of her, if I could.
My dad used to say that his biggest wish was to have a thousand more of me. I still remember how loved it made me feel. Ivy will too.ReplyDelete
she is adorable, and looking so grown up!!!!
I love ding pigtail on our girls too :-)
Something precious happened here. ♥ReplyDelete
She's just darling. :-)ReplyDelete
Love this photo, with her little foot bent just so.
And yes I say little. Her feet will be too big when she is 12 and asking to borrow your shoes because she can't find the mates to hers.
Pig tails and foot wrinkles--darling!ReplyDelete
love the pigtails!ReplyDelete
so so cute!
I wish for pigtails too. My little girls still has to grow some more hair, though.
hugs from Brazil!
I love pigtails on little girls! So cute.ReplyDelete
I feel the same way about my little one :)ReplyDelete
super sweet. and totally get this. i know.ReplyDelete
she's SO grown up! love her sweet pigtails and that awesome tunic. enjoy your long weekend with your family!
--Dr. Dolly
I would be going for a thousand more myself right now, if I had any idea where they would all sleep. ;)ReplyDelete
That picture is nothing short of precious. Her sweet pig tails, "piggies" and face. I can see why you'd have so many more... :)ReplyDelete
What a precious photo! She is a cutie!ReplyDelete
She's wonderful :)
So precious :)ReplyDelete
Are her feet stinky? I'll bet they're just the right kind of stinky that I adore.ReplyDelete
Are her feet stinky? I'll bet they're just the right kind of stinky that I adore.ReplyDelete
i love her curled toes. so kid.ReplyDelete
so amazingly cute!!ReplyDelete
They grow so fast don't they? And yet somehow when they sleep still look as angelic as the day they were born.ReplyDelete
Those pigtails make my uterus cry!!
Her feet DO look big...and sweet and cute a chubby.
I LOVE this picture and the sweet contentment on her face.
listening to her say my name is music to my ears. love her so much.ReplyDelete
love the curled toes. priceless.ReplyDelete
My almost-4-year-old (her birthday is Thursday!) has been requesting pigtails lately...and I love it!
You should see her w/ her pigtails, her pink eyeglasses, and her brown boots. She is exquisite.


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Top Definition
The friend you bring along to bars specifically to distract the over protective fat chick while you get with the hot girl. He comes with because he is either attracted to fatties, or has no self esteem.
Sounds like you need a Buffalo Wingman, call Danny.
автор: vallada 10 сентября 2010
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Can you define these popular missing words?


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Thursday, August 28, 2014
Ive been paying a lot of attention to advertising signs and billboards while on the road lately. I dont text and drive during my frequent travels, but I do take the occasional peek at the signs along the way.
And Im all about subliminal messaging.
My problem is, I dont think the subliminal message I take away from these signage glimpses is the message advertisers had in mind.
For example...
A billboard spotted along Hwy. 17A between Moncks Corner and Summerville said this: Low cost toothpick sized dental implants...
There is nothing about the phrase toothpick sized that offers any comfort when it involves sticking something toothpick sized anywhere in my mouth except perched on my lower lip.
It hurts just reading it, but the sign makers added a visual aid of the inside of my mouth to show what they meant by implant.
Implant means to permanently attach by any method possible. They want it stuck, but good.
I have problems with dentists to begin with. I dont want anybody anywhere near my mouth wielding a hammer and a bunch of ten-penny nails and saying, Open wide, this will pinch just a little.
Driving onward, I was stopped at a traffic light behind a mini-van covered with advertisement signs touting the services of a local tanning, nail and electrolysis establishment.
The sign said: Hair Removal Wax JUST $65, Laser Treatment $99.99.
Translated... For just $65, we will surgically remove your liver using nothing but duct tape.
I dont know what sadistic malcontent invented the waxing process anyway. You spread hot wax the consistency of peanut butter up and down your leg with a Popsicle stick.
Once the wax is in place and before it cools, you press on strips of butcher paper, and wait.
When you feel like the wax and paper have formed a solid bond you then grab hold of the paper strip at the corner, count down 3, 2, 1..., whisper a quiet prayer asking for swift deliverance from Dantes Fifth Level of Hell, and yank hard.
As for the laser treatment reference, Ive seen all the Star Wars and Star Trek movies and I know what lasers can do.
The descriptive metaphor Sizzle! usually follows.
During my radio days I signed an endorsement deal with a local laser treatment facility, only in this case the laser therapy was designed to relieve stress and help you relax.
Just lie back and relax, the gum-popping technician said as she fired up the thermo-nuclear device.
The lights dimmed, but only for a minute.
Where do you aim the laser? I queried.
At the center of your forehead, right between the eyes, came my gum-popping reply.
And what is the laser supposed to do?
It pentetrates deep inside the hypothalmus and cauterizes the node endings that controls misbehavior, malfeasance and general irritability, she said with a smile.
Didnt they call that a frontal labotomy in One Flew Over the Cuckoos Nest?
No thanks.
I saw what that did to Jack Nicholson.
I was doing laundry over the weekend and had purchased an off-brand economy sized bottle of detergent.
It said: New and Improved laundry detergent... MORE concentrated USE LESS.
Translated... Its useless.
It says so right on the bottle.
Maybe the summer product marketing intern didnt get the job offer he wanted and decided to say good-bye with style.
The labels intent was to convey economic laundering by using less detergent, but when you spy the detergent bottle from 15 feet away and youre not wearing your bi-focals, USE LESS gets blurry and becomes USELESS.
Maybe Id be better served keeping both eyes on the road.
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We couldn't wait for Wednesday to come to show you all the wonderful Inspirations the Design Team has put forth for you!
Have you been to the 2 red banana stamp company lately? if not what are you waiting for?
2Red bananas offers fun, deep etch stamps that sure to complement any projects!
Today they are releasing their fifth set of exclusive stamps.
Guess what? in addition to winning the new folders, we will be giving a set of stamps of your choosing from 2Red Bananas.
Visit their store and the blog for fantastic ideas here and here.
Want a sketch challenge this week? Let's face it who doesn't like a sketch right?
Use the sketch below as a stepping stone, you can rotate it, add more etc... The design team challenge this week was to feature the Herringbone folder
Bonus folder this week is the Textile folder!
Provided by Mlamarredesigns :)
Isn't it Amazing the wonderful designs our team has created using the provided sketch? Wowzers!
We want to thank the Design Team from 2 red Bananas for participating in our sketch challenge this week!
Deb Felts (2 Red Bananas)
Jeanette Fincher (2 Red Bananas)
Wendy Kastne (2 Red Bananas)
Teresa Grau(2 Red Bananas)
Cassie Larson
Cassie Larson
Ingrid Danvers
Jenyfur Pohl
Hanneke van Dalen
Hanneke van Dalen (alternate view)
Betty Brett (front)
Betty Brett (inside)
Shantaie Fowler (card)
Shantaie Fowler (card and bag))
Rosemary Zuba
Nathalia Castellon
June Houck
Karen Maldonado
Ewonne Ek
Beth Ullman
Amber Goble
Heidi Van Laar
Jenn Koss
Angie Tieman
Jackie Gallagher
Tracy Pounds
Michelle Borsack
Terrie Bailey (tag)
Terrie Bailey
TerrieBailey (Christmas card)
Sonia Kertznus
Meda Halmaciu
Dannisdoodles (card 1)
Dannisdoodles (card 2)
Dannisdoodles (card 3)
Dannisdoodles (card 4)
Dannisdoodles (ensemble)
We are excited to see what you have created, please leave a link below and let us know what you think of the challenge and the Inspirations the design team provided. If you are uploading your projects to online galleries, please use keyword CuttlebugBI40
The more participation we get for this week the more folders we will be giving away!
You have until July 31 to enter all the challenges for the month :)
We are striving to bring you the best challenges and inspirations weekly. Tell us what kind of challenges you would like to see on this blog?
As always don't forget to help us get 1500 followers by the end of this month. Add us to your blog and becoming a follower. :)
Have a fantastic week, Happy Scrapping.


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The Slogan of the Boy Scouts is simply, DO A GOOD TURN DAILY.
What does that ask of us? Well it does not mean to do one good turn a day, but to always look for chances to help throughout the day.
You never have to look for good turns, they find you…but only if you have your eyes open and your mind ready to see them.
A good Scout does the good turn, no matter how small, no matter how large. It can be as simple as carrying a load of groceries or as big as saving a life. The point is the opportunity is there and the choice is yours.
Every day I try to do a good turn, they surround me. Notice I said try. The Scout Oath tells us to "DO OUR BEST" Sometimes you find yourself in a position that you can not help. And that is OK, as long as you are aware and see the next opportunity.
Remember always that a good turn is an extra act of kindness. It is not just something you do because it is good manners. To answer a question of a driver about reaching a location is not a good turn, it is common courtesy, drawing him a map for him that will show him how to get there- now that is a good turn. (Boy Scout Handbook 9th Edition)
There are many examples of good turns, just remember that they are all around you. Opportunity is always knocking…do you hear it?
Do a Good Turn Daily!
Happy Scouting


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Direct and Intermediated Marketing of Local Foods in the United States
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Economic Research Report No. (ERR-128) 38 pp, November 2011
This study uses nationally representative data on marketing of local foods to assess the relative scale of local food marketing channels. This research documents that sales through intermediated marketing channels, such as farmers' sales to local grocers and restaurants, account for a large portion of all local food sales. Small and medium-sized farms dominate local foods sales marketed exclusively through direct-to-consumer channels (foods sold at roadside stands or farmers' markets, for example) while large farms dominate local food sales marketed exclusively through intermediated channels. Farmers marketing food locally are most prominent in the Northeast and the West Coast regions and areas close to densely populated urban markets. Climate and topography favoring the production of fruits and vegetables, proximity to and neighboring farm participation in farmers' markets, and good transportation and information access are found to be associated with higher levels of direct-to-consumer sales.
Keywords: Local foods, direct marketing channels, direct sales, intermediated sales
In this publication...
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Last updated: Sunday, May 27, 2012
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News Posts
Watch Tonight's Asimov Memorial Debate at amnh.org/live
by AMNH on
Watch the 2013 Isaac Asimov Memorial Debate, moderated by Hayden Planetarium Director Neil deGrasse Tyson at the American Museum of Natural History, on Wednesday, March 20, at 7:30 pm EDT on amnh.org/live.
Cooking, Deliciously, with Common Weeds: A Q&A with Tama Matsuoka Wong
by AMNH on
Tama Matsuoka Wong did not set out to be a professional forager. But, slowly, as the then-corporate lawyer lived internationally, she developed an obsession for eating wild plants. Today, it's her vocation as well. Wong will give a talk and tasting this Thursday, March 21, 2013, as part of the Museum's monthly Adventures in the Global Kitchen series. We recently talked with her about her approach to eating from "nature's garden."
March Mammal Madness: Round Two
by AMNH on
Nearly 3,000 people cast their vote during our first round of March Mammal Madness, narrowing the possible names for our hypothetical common placental ancestor down to 16. Help us narrow down the choices even further by voting for your favorites below. You have until 5 pm EDT on Tuesday, March 19, to make your selections.
Pelican Island at 110 Years
by AMNH on
On March 14, 1903, President Theodore Roosevelt issued an executive order setting aside Pelican Island, Florida, as the very first national wildlife refuge. Today, it remains an essential breeding ground for migratory waterfowl—and one of 561 wildlife refuges overseen by the U.S. Fish and Wildlife Service. Daniel M. Ashe, director of the U.S. Fish and Wildlife Service, recently discussed what Pelican Island is like today.
March Mammal Madness: Round One!
by AMNH on
The "Name Your Ancestor" contest resulted in more than 1,000 name suggestions for the hypothetical common placental ancestor that scientists described last month. The top 32 contestants, as selected by the Museum and WNYC's Radiolab, range from serious to silly. Starting today, we need your help to pick the winning moniker for this small, furry, insect-eating mammal.


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Sigma 30mm F1.4 EX DC HSM Canon
Further readings for the Sigma 30mm F1.4 EX DC HSM Canon
To provide photographers with a broader perspective about mobiles, lenses and cameras, here are links to articles, reviews, and analyses of photographic equipment produced by DxOMark, renown websites, magazines or blogs.
After achieving an excellent reputation for its imaging characteristics, Sigma has revised this popular high-speed APS-C format standard lens, adding it to its high-performance Art line. Read on to see how well this new iteration performs in our labs.
Even though it appeared in Canon's lineup in 1995, the Canon EF 28mm F/1.8 is one of the most recent wide-angle prime lenses for full-frame cameras. Built around 10 elements in 9 groups with one aspherical element, this lens feels pretty solid in hand. Its ultrasonic motor (USM) makes it very silent and quick to focus. In terms of image quality, the Canon EF 28mm F/1.8 provides a really good value for money.
Tamron SP AF 28-75mm F/2.8 XR Di LD Aspherical [IF] tested on Canon and Nikon mount.
Launched in 2003, this lens is still a very good choice if you are looking for a cheap standard zoom lens. See the comparisons against famous competitors: Tamron SP AF 28-75mm F/2.8 XR Di LD Aspherical [IF] Nikon Vs Canon EF 24-70mm f/2.8L USM Vs Nikon AF-S Nikkor 24-70mm f/2.8G ED, here.


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WASHINGTON (AP) - Big differences remain, but there is finally movement in long-stalled talks on avoiding the "fiscal cliff."
House Speaker John Boehner is offering $1 trillion in higher tax revenue over 10 years and an increase in the top tax rate on people making more than $1 million a year. He's also offering a large enough extension in the government's borrowing cap to fund the government for one year before the issue must be revisited.
In return, Boehner is asking for $1 trillion in spending cuts from government benefit programs like Medicare.
Democrats rejected the offer and say an increase in the Medicare eligibility age is a non-starter.
Boehner's proposal was described by officials familiar with it. They required anonymity because of the sensitivity of the talks.


text: In a recent column, Mr. Sean O'Leary criticized Delegates Overington, Householder and some West Virginia sheriffs for defending our rights by asserting state sovereignty. Mr. O'Leary's premise is all "legally enacted laws" (his words) and all U.S. Supreme Court findings must be enforced. His opinion suggests a need to familiarize himself with history. Mr. O'Leary should be aware by now of the civil disobedience to "legally enacted laws" by Rev. Martin Luther King and legions of others, both black and white. He might have read of "legally enacted laws" against Jews in Germany in the 30s. He may even know of the U.S. Supreme Court finding in Plessy v. Ferguson which upheld segregation of colored and white in the then Democrat Solid South. Yet Mr. O'Leary states all laws and Supreme Court decisions must be obeyed. (And Mr. O'Leary is an honorable man.) Obviously all laws are not created equal; there are good laws and bad laws, just laws and unjust laws, good governments and bad governments. ... Which brings us to the essence of our present dilemma.


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on November 9, 2012 - 10:41 PM
What's in a name?
Chris Collins left public office a year ago without a warm, fuzzy reputation.
The former county executive now looks to burnish a new image as he prepares to take on a new title.
And he was all smiles after his narrow victory over Democrat Kathleen C. Hochul.
The magnitude of his new job sunk in quickly as he celebrated his win with his wife, Mary, and campaign staff at GOP election night headquarters.
"Congressman!" someone shouted as the group posed for a picture.
"I've been called a lot of things in my life," Collins quipped. "But never congressman."
Horse laughs
Defense attorney Thomas J. Eoannou can be aggressive, feisty and, at times, a fast talker in a courtroom.
He can also become a bit tongue-tied.
The animal-cruelty trial resumed this week for his client, Aurora horse farm owner Beth Lynne Hoskins.
Eoannou cross-examined SPCA veterinarian Jean Feldman for three hours about the agency's 2010 raid at Hoskins' farm.
He had moments when he performed with flourish and gusto.
And then he had other moments. Like when he asked Feldman about her use of blow guns on the horses.
"Did you ingest the horse?" he asked.
"I didn't ingest the horse," Feldman replied. "It wouldn't have been very tasteful. I injected them."
Eoannou called the veterinarian "ma'am" until the prosecution insisted to the judge that he call her "doctor" or "Dr. Feldman."
Even that proved a challenge for Eoannou at times, when he returned to his "ma'am" mode.
When Feldman testified she did not see any horse eat manure, Eoannou called her out on that answer, saying she had previously said she had but failed to do a diagnostic exam to confirm that horses were eating manure.
"There is not a diagnostic test that you could do for manure," Feldman told the attorney. "How would you test what they're eating, when what they're going to eat is going to come out their rear end and look the same?"
A split ticket
Whether your favorite won or lost the White House, the presidential outcome could have been more unsettling.
A week ago, the Washington Times' Inside the Beltway column quoted Canisius College political science professors Michael Haselswerdt, a Democrat, and Kevin Hardwick, a Republican, on the viable chance the two candidates could split the electoral votes, 269-269.
If that had happened, the Republican-led House would have picked the president and the Democrat-led Senate would have decided the vice president.
"That means that Joe Biden would be vice president for the next four years under President Mitt Romney," Hardwick said.
"We would have the 'Odd Couple' on steroids."
There's an app for that
A lot of us have heard of Angry Birds, the popular game downloaded onto millions of mobile phones.
Now a new app is out, and criminals in Cheektowaga had best beware.
It is not called Angry Residents or even Alert Residents, though these names would be fitting.
The Cheektowaga Police Department has a new, 21st-century crime fighting tool – an iPhone app for sending anonymous tips.
The free app also allows police to respond for an anonymous, two-way chat.
Police Chief David Zack likes the idea.
"This tool ... will help our citizens play an active role in keeping neighborhoods safer, it will engage younger folks in the process, and it will save our agency time and resources."
The CPDNY Tips iPhone app can be downloaded at the iTunes store or through www.tocny.org/departments/police.aspx.
If it is anywhere close to as popular as Angry Birds, where angry birds are catapulted at egg-stealing pigs, we may see the book thrown at more criminals in the town.
By Patrick Lakamp with contributions from Denise Jewell Gee, Maki Becker and Karen Robinson. email: firstname.lastname@example.com


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Source: CNN
quote: what about the SDK(an apple invention)
quote: ugh, there i go, writing too much
quote: i am convinced most of the apple haters don't actually know anyhting about the tech and the benefits of running os X (native productivity apps and unix side by side) pss. go fuck yourselves DT
quote: save space by taking out CDROMS
quote: double the standard resolution on their laptop line
quote: implement intels thunderbolt
quote: the fact that most of DT users ignore Apples moves as influential and, at times, ahead of the curve, just shows that you don't understand consumer tech.
quote: at the end of the day flash isn't compatible with touch
quote: it isnt compatible with battery life
quote: it isn't compatible with 2012
quote: ugh, there i go, writing too much.
quote: apple shouldn't be compared to budget brands on price! thats ridiculous.
quote: they put effort into pushing a new standard that everyone copies and they will not put out cheap products.
quote: the fact that everyone can afford an iPhone just proves my point.
quote: Soon enough, however, they will drop in price
quote: remember powerpc's?
quote: i haven't enabled flash on my macbook
quote: i've taken the cdrom drive out of my last 3 macbook pros to throw in an additional HDD (talk about not upgradable)
quote: and i am tech savvy.
quote: i am convinced most of the apple haters don't actually know anyhting about the tech and the benefits of running os X (native productivity apps and unix side by side)
quote: my apple is running office v14/2011
quote: with a leap in logic like a fox news journalist taking things out of context
quote: i clearly stated doulbed resoltuion on their 15" books.
quote: cdroms went the way of floppies
quote: dunno why your comparing a 17" notebook to a 15" notebook
quote: you really had a hard time with my post, cuz i'm right
quote: but firewire was and still is faster than usb
quote: i dunno what your point is but your point sucks
quote: if you are denying the clear trend setting and influence apple has over the market then you're just delusional
quote: Cupertino users, as a whole, do not necessarily reflect the platform as a whole.
quote: it is made to be simple
quote: apologize for no paragraphs, i don't have time for formatting and would rather just say what i gutta say.
quote: its not a speed problem per se
quote: sites only use flash for advertising these days.
quote: why the hell woudl i want windows 7 to be productive?
quote: but i think a third party observer would see my point remains
quote: apples sets the standard and the rest of the pack catches up.
quote: apples tends to leave certain techs out (NFC) for whatever internal reasons
quote: i am not a PC hater.
quote: don't know your shit don't comment
quote: I'm holding out on the retina devices for a number of reasons
quote: i tend to buy last gen apple stuff cuz it marks down significantly.
quote: windows is weak and linux is a headache.
quote: my hope is that apples SSD charge will go down as more units sell.
quote: do you see how all of these things dont' change my point?
quote: the question is who said i wanted to run windows 7 and office 2010?
quote: who said i want to pay for the retina display
quote: apple still sets the trend.
quote: nice shot, but i win
quote: 1. the rest of my points you fought with a leap in logic like a fox news journalist taking things out of context.2. don't know your shit don't comment.
quote: i forgot this: http://en.wikipedia.org/wiki/Newton_(platform)you mentioned palmtops. apparently this was risc, too, and came before its kind. man apple, you just such a follower. history of following. nothing trend setting or influential to see here. move along, sheep


text:
Top Definition
When you bend a girl over in bed and fill her asshole with whipped cream. Then swiftly give her an uppercut to the gut and enjoy watching the booty snowflakes fly.
Hey dude, what did you do last night? Oh you remember that bank teller that was going to come over for some wine and scrumpets? One thing led to another and before I knew it... I was snowblowin' her so hard that we got whipped cream on my ceiling fan. I think the last uppercut to the gut busted her belly button open.
von idoiteveryday 31. Oktober 2011
Trending Now
Can you define these popular missing words?
When a man ejaculates into a womans mouth and she spits(sprays)it on his face.
"I told that bitch she better not think about snowblowin, cause if she agree to it she better take it."
von Sairah 26. Oktober 2003


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Trident Technical College has landed on a list of schools where student loan default rates exceed graduation rates.
The S.C. list
South Carolina schools on USA Today's "red flag school" list:
School Grad. Default rate rate
Allen University 8% 27.1%
Benedict College 27% 29.3%
Denmark Technical College 13% 33.6%
Greenville Technical College 11% 14.7%
Horry-Georgetown Technical College 12% 12.7%
ITT Technical Institute-Greenville 30% 34.1%
Midlands Technical College 7% 13.0%
Miller-Motte Technical College 16% 25.2%
Morris College 25% 27.5%
South University-Columbia 21% 21.5%
Trident Technical College 7% 12.7%
University of South Carolina-Sumter 7% 8.8%
The list came from a report that ran last week in USA Today, which analyzed data from the U.S. Department of Education and found 265 such schools in 40 states. It called them "red flag schools." There are 12 of them in South Carolina.
Cathy Almquist, Trident Tech's director of institutional research, said the college, which according to the report has a 7 percent graduation rate and a 12.7 percent default rate, made the list because of its low graduation rate. School leaders are aware of the graduation rate and have programs in place to begin to address it, she said.
Almquist also said she is not trying to make excuses for a low graduation rate, but she thinks the numbers in the USA Today report don't tell the whole story. The graduation rate the newspaper used is based only on students who enrolled full-time in the fall of 2009 and graduated within three years. Trident Tech has many adult and non-traditional students not included in that rating, she said. And many of its students have work and family responsibilities, so they complete programs more slowly.
Miller-Motte Technical College, which has a campus on Rivers Avenue in North Charleston and another in Conway, also landed on the list, with a 16 percent graduation rate and a 25.2 percent default rate.
Chuck Vella, a spokesman for Miller-Motte, said in a statement that the company has several issues with the USA Today report, including that it appears to have combined both South Carolina campuses, likely is based on data only for students entering in the fall when Miller-Motte students enroll four times a year, and does not use the most current available default data.
Almquist said there hasn't been a strong campus reaction to the USA Today story, likely because there were no students and few employees on campus last week.
And she said the state's Commission on Higher Education has developed a "success rate" for the state's technical colleges that it considers along with the official graduation rate. The "success rate" builds on the graduation rate by including full-time students who transferred to other institutions or still are enrolled.
Trident Tech's "success rate" is about 49 percent, she said.
And the college has been working for years to boost both rates, she said, including a massive class schedule shift that will be fully in place by the fall of 2014.
Students tend to do better in classes that are shorter in duration, for instance those that run for seven weeks instead of a full semester, she said. By next year, almost all Trident Tech courses will run for seven weeks but will cover a full semester of content.
For example, a student who used to take four semester-long courses at a time would take two seven-week courses at a time. That student still would complete four courses in a semester but would be juggling only two at time. Research confirms that students fare better under such a system, Almquist said.
She also said financial-aid officers are working with students to help them better manage their student loans. The school's default rate is not high compared with others nationally. The school made the list because of its low graduation rate, not its high default rate.
Trident Tech's default rate is one of the lower ones on the USA Today list, on which many schools have rates higher than 30 percent.
Reach Diane Knich at 937-5491.


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It's long been assumed that the pending lockout between NFL players and owners wouldn't have any affect on the 2011 NFL Draft. However, while the draft will still go on as scheduled, teams may have to approach it completely differently.
Until a new collective bargaining agreement is reached there will be no free agency, no rookie wage scale and, as of now, no regular season. These three realities will drastically alter many team's draft strategies.
But how?
With this question in mind, here's my latest mock draft. Follow the links below to see previous versions.


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The Stetson University softball team has been picked to finish sixth in the 2014 Atlantic Sun Conference preseason coaches poll, while senior Meredith Owen was a unanimous selection to the Preseason All-Conference Team.
The Hatters, who were 31-22 overall in 2013 and 13-13 in the A-Sun, received 51 points in the poll, seven points behind fifth-ranked Kennesaw State.
Defending tournament champion USC Upstate received seven first place votes (97 points), while Florida Gulf Coast (85) was second and Lipscomb (78) was third. Last year's regular season champion North Florida (77) was awarded a fourth place ranking, while Kennesaw State (58) was slotted for fifth, one spot ahead of Stetson. Jacksonville (43), Mercer (31), Northern Kentucky (18) and ETSU (12) round out the preseason poll.
Owen made the A-Sun's Pre-Season All-Conference Team as a designated player/utility and was one of two unanimous selections. She also won the fan vote for Preseason Player of the Year, which was voted upon through the Atlantic Sun Facebook page. Owen led the Hatters with 11 home runs in 2013, a season in which Stetson set a new program record for long balls with 45. The Jackson, Miss., native also led the Hatters in average (.318) and RBI (37). She had an equally successful season in the circle, going 22-10, with a 1.96 ERA and 27 complete games.
The Hatters open the 2014 season on Friday, Feb. 7 against Michigan State and Rhode Island in the Stetson Lead-Off Classic at Patricia Wilson Field. For season ticket information, call the Stetson Athletics ticket office at (386) 738-HATS or go online to gohatters.com/tix.


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Create a space you'll love. Use decorative painting techniques to add a hint of style.
Transform your home with decorative paint finishes inspired by Benjamin Moore's Paint Style, a book dedicated to the art of beautifying your home. With more than 180 exquisite images illustrating how to create a multitude of tonal effects, faux appearances, patterning and textural designs, Paint Style will instill in you the imagination and confidence to interpret your style in a whole new fashion.
In our Paint Style book, Benjamin Moore's expert painters and designers cover every possible detail to ensure picture-perfect results, providing clear instructions for each of the following decorative painting techniques:
Get inspired with wood-grains, marble and limestone look-alikes, tone-on-tone stenciled damasks, or a pearlescent hued wall encrusted with sea shells.
You can purchase Paint Style only from our
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You can also watch our videos on decorative paint finishes.
Note: On-screen and printer colour representations may vary from actual paint colours.


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Wednesday, February 26, 2014
Bishop England seniors Michele Boykin and Mary Harriet Moore walked off their home court for the last time Tuesday, much in the same way they always left it, as dominant winners.
Bishop England blew past Battery Creek, 76-38, in the third round of the Class 2A state playoffs to earn its third straight bid to the Lower State championship game.
Boykin scored a game-high 36 points on 78 percent shooting with eight rebounds, six steals and eight assists. Moore added 16 points, 17 rebounds and three blocks. Just what you'd expect in the final home game from two of the best to don the Bishop green and white.
"They both went out in style," Bishop England head coach Paul Runey said. "It was a great last game in this gym for the both of them. It's remarkable. They're two of the most accomplished players I've ever coached and you just come to expect games like tonight from them."
The Lady Bishops (25-1) focused on limiting Battery Creek star Daisja Cannon and forcing the rest of the team to try to beat them. Jo Jo Tompkins, Anna Marie Penninger, Erin Rose and Montana Swanson took turns harassing Cannon in Bishop England's box-and-one defense. Cannon scored 14 of Battery Creek's 17 points in the first half but managed just four in the second half. Boykin scored 12 in the third quarter, Moore added eight and the Lady Bishops turned a 13-point halftime lead into a 26-point rout by the start of the fourth.
"It's hard to shut a player like (Cannon) down, but I thought we did a good job of wearing her out," Runey said. "We knew we were the deeper team so we were able to keep somebody on her the whole game.
"I thought all our kids played really well. We made the right plays with the basketball, ran the floor really well. We needed that going into these next games."
Bishop England advances to face undefeated Dillon (27-0) Saturday in the Lower State championship game at the Florence Civic Center. Dillon stole a win from Kingstree with a free throw in the final seconds Tuesday. A Bishop England win Saturday would mean the Lady Bishops' third straight Lower State title, Runey's 590th career win, and a chance at their second state championship in three years.
"These girls have already shown that they have the athletic ability to win these types of games," Runey said. "They're good about playing in these big games. They know how to win and that's a big deal. This isn't something new to them."
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As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
Quadruple Helices Appear To Have Role...
Expanding Use of NGS Has Largely...
Hydrophobic-interaction chromatography and reversed-phase chromatography (HIC/RPC) for large-scale separation of proteins was the focus of a series of talks at Tosoh Bioscience's recent "HIC/RPC Bioseparation Conference: Advancements, Applications and Theory in Downstream Processing."
The program provided a balance of theory, practical applications, scale-up tools, and state-of-the-art resins and media for HIC, RPC, and multimodal chromatographic purification of therapeutic biomolecules. Topics ranged from the fundamentals of chromatography; quality by design; protein structure, interactions, and stability; novel stationary phases; and industrial case studies.
Mixed-mode chromatography has proven to be a valuable alternative to conventional ion-exchange (IEX) or hydrophobic-interaction chromatography for purifying monoclonal antibodies primarily due to the technique's high selectivity. This technology is increasingly being applied to other challenging nonantibody therapeutic proteins for which large-scale downstream separation and purification protocols often introduce unwanted process bottlenecks and cost barriers.
Xuemei He, Ph.D., senior staff scientist, process chromatography division, Bio-Rad Laboratories, described the use of Nuvia™ cPrime™, a hydrophobic cation exchange media, for mixed-mode chromatography for the purification of a variety of recombinant proteins expressed by prokaryotic or mammalian cell lines. Dr. He cites the main advantages of Nuvia cPrime as high selectivity, tolerance of load conductivity, and gentle purification conditions.
Nuvia cPrime is composed of a functional ligand on a base matrix of macroporous hydrophilic polymers. Potential interaction modes for protein binding include weak cationic exchange, hydrophobic interaction, and hydrogen bonding. Using lysozyme isolation from an E. coli lysate as an example, Dr. He presented two different purification method development schemes and associated optimization strategies.
In the first example, she investigated the effect of buffer salt concentration and pH on the purity and yield of final product via a design of experiment (DoE) approach. The "sweet spots" for optimal yield and purity of lysozyme were identified using a set of 11 experiments that covered the pH range of 4–8 and NaCl concentration range of 10–400 mM for binding and 10–1,000 mM for elution.
In all of these experiments spin columns containing 50 µL of Nuvia cPrime media were used. Purification conditions obtained from these DoE screening tests were experimentally confirmed as being effective for host cell protein and double-stranded DNA removal, and were suitable for use in production scaleup.
In the second purification method development strategy, Dr. He described an approach based on creating different types of buffer gradients on a traditional chromatographic column—pH, conductivity, or elution with additives. Each of these methods was tested for yield and purity of target protein. They were then refined and converted to a step elution protocol for larger scale production.
Mixed-mode chromatography offers additional advantages for protein separation and purification, according to Dr. He. With options for efficient target protein elution and tolerance of a range of feed conductivity, this technique often allows easy transition between chromatography unit operations, thus eliminating the need for dilution and extensive feed manipulation.
"Despite the fact that multiple functionalities may be employed for selective target protein binding, chromatographic methods can still be developed in a straightforward fashion by looking into the effects of buffer pH and conductivity on purification performance," she said.
Dr. He also presented case studies on a diverse set of therapeutic proteins, including highly glycosylated recombinant viral antigens and monoclonal IgGs and IgMs, which demonstrated the efficient removal of process and product-related impurities such as degradation fragments and high molecular weight aggregates.
James Woo, from Rensselaer Polytechnic Institute, presented a study comparing the retention of a library of common proteins on a variety of multimodal cation-exchange ligands, including Bio-Rad's Nuvia cPrime resin. The study explored the effect on protein retention of changes in the ligand chemistry and geometrical presentation of the functional groups—the effects of weak vs. strong charges at pH 5 in 20 mM acetate solvent, and the effects of secondary groups and hydrogen bonding.
The results indicated that protein retention tended to decrease with increased charge and was affected by even subtle changes in ligand chemistry. Certain hydrophobic proteins, such as serum albumins, were selectively excluded from the resin, suggesting that by elucidating the role of different functional groups and modulating the design and hydrophobic nature of a multimodal ligand it is possible to cover an expanded design space and target specific selectivities for a given multimodal process step.
Egbert Müller, Ph.D., technical director at Tosoh Bioscience, discussed the need for novel purification methods to isolate mAb fragments that are increasingly being developed as drug candidates, because conventional Protein A-based separation methods that target the Fc component of the mAb may not be suitable.
Dr. Müller's group evaluated the use of the Tosoh Bioscience product Toyopearl MX-Trp-650M mixed-mode resin to purify a F(ab)2 fragment and other antibody-derived molecules, and compared the effects of different buffer systems on the separations.
Dr. Müller described several advantages of mixed-mode chromatography including high selectivity, high loading capacity, and high efficiency. He discussed the mechanisms of cationic (weak acid) mixed-mode chromatography, including basic ion exchange with adsorption via electrostatic attraction at pH 4 followed by desorption by charge screening of the analyte at pH 5.0–6.5, which yields a combination of high binding capacity and good recovery. He cited examples in the literature of the use of immobilized amino acids such as lysine, histidine, tyrosine, and tryptophan as cationic mixed-mode ligands.
The Toyopearl MX-Trp-650M resin has a mean pore size of 1,000 Å, a mean particle size of 75 µm, and a pH stability range of 3–13. It maintains a high dynamic binding capacity at elevated feedstock or buffer conductivities, and after extended clean-in-place cycles using 0.5 mol/L sodium hydroxide, and it offers fast binding and elution kinetics, according to the company.
Dr. Müller illustrated a bind-and-elute method using immobilized tryptophan for mAb aggregate removal. The pH and conductivity gradients increased at the same time with this technique, using 1 M HCl to titrate the pH to 2.7, and the result was greater separation, he said. When they experimented with a dual salt mixture the separation improved even more, and Dr. Müller noted the greater flexibility that mixed-mode resins allow in modulating the process parameters.
In another experiment, the group evaluated the distribution of the hydrophobic sites on IgG and the interaction of the Fc component with tryptophan on purification of a mAb pepsin digest on Toyopearl MX-Trp-650M. The mixed-mode chromatographic separation was able to isolate the Fc component, and a subsequent study demonstrated successful binding of a scFv to the immobilized tryptophan as well.
A protocol designed for scFv polishing using MX-Trp-650M yielded two adsorption peaks and an aggregate content of 65%. The group used Protein L to optimize the gradient and reduce the aggregate content, which required dropping to a pH of 2.5. With standard resin the aggregate content did not go below 15%; with the Toyopearl resin the aggregate content was reduced to 3%.
Dr. Müller concluded that the resolution of the different mAb-derived species can be increased significantly using mixed-mode chromatographic resin. "We think the adsorption mechanism of proteins on Toyopearl is electrostatic and hydrophobic and might be related to its salt-dependent pK value," he said. In addition, "in contradiction to the literature, we were able to separate antibody fragments by the immobilized tryptophan ligand," separating the F(ab)2 and Fc fragments formed on pepsin digestion.
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text:
I'm glad some words to imply judges who like hanyu are sadist disappear.Thank you Tonichelle !
Hmmmm... so the ever probity JSF has become injusticed organization because they has switched their focus from favoring Takahashi into favoring Hanyu. Love it!
Last edited by Bluebonnet; 12-29-2012 at 11:04 PM.
Let's stick to the skating/skaters, not each other.
I've never said it was right. I have just pointed out the fact that the roar on JSF's favoritism has just broken out after Takahashi was subsided in Japan as the second best.
Japan has been having favoritism all the time, long before Hanyu was on the scene. Last season, Takahashi was clearly the favorite and won the overall competition with the infamous 3 fall in one single program. But the deslike on the favoritism of JSF has hardly come up at that time.
Every federation has its favorite skaters. JSF has never been an exception.
Favoritism is unaceptable a priori. When it comes to shameful judging, then the concept of chanflation and hanyuflation shows up. JSF had the worst event this season with NHK (thanks to Ladies) getting quite close. Both events were in Japan, where JSF will be beating SC controversy in fs world quite soon. While Russian Nationals is probably the only official event this season that didn't arise any questions regarding medalists in all segments. The later issue with the 3rd spot for Euros in Men only proved it. The diference between 3rd-5th place was quite small. So, if judges were under the influence of federation's favoritism, they would fix the score "right". They didn't. So, the statement about every federation has favourites has no merit either.
I think we need to remember that a lot of this discussion still comes down to everyone posting an opinion. I think that's where folks are getting confused/angry/offended. It's ok to put "IMO" after your statements once in a while.
And, beating the same horse to death over and over just to have the last say and come out looking the victor gets old for the rest of us. Everyone's said their bit, let's move on in the discussion or to the next competition.