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SYCAMORE - The last time Fremont St. Joseph Central Catholic won an outright Midland Athletic League football championship, Zack Yeckley was barely big enough to pick up a football.
Now he's throwing the ball around with the best of them. Actually, he is the best his school has ever seen.
Yeckley tossed two more touchdown passes to give him 29 for the season and he became SJCC's all-time leader in passing completions, yards and touchdowns for both season and career.
In the process, he led the Crimson Streaks to a 33-8 win over Mohawk Friday night. Two years after they had to share the league championship because of a final-night loss here, the Streaks are all alone at the top at 7-0.
"This is the best feeling ever," Yeckley said after he completed 9-of-16 passes for 151 yards during an all-night rain. "But the only record I'm worried about is 9-1 and taking it to whoever comes to Don Paul Stadium next Friday night in our playoff game."
St. Joseph was bounced 43-14 by Division V playoff qualifier Liberty-Benton in the season opener and then rattled off nine straight wins.
Fact Box
Fremont St. Joe 33,
Mohawk 8
St. Joe76137 - 33
Mohawk0008 - 8
First Quarter
SJ - Alex Veleba 42 pass from Zack Yeckley (Corey Durbin kick), 9:41
Second Quarter
SJ - Yeckley 3 run (pass failed), 6:14
Third Quarter
SJ - Marcus Kerr 55 run (pass failed), 6:38
SJ - Jordan Sessler 41 pass from Yeckley (Durbin kick), 5:30
Fourth Quarter
SJ - Luke Stierwalt 1 run (Durbin kick), 11:08
M - Drew Loose 34 run (Logan Stillberger run), 1:33
First downs107
Passing yards15125
Individual statistics
RUSHING: St. Joseph - Kerr 22-115; Yeckley 9-16; Cameron Wasson 2-1; Mitchell Gonya 2-1; Nick Magro 2-(minus 1); Stierwalt 1-1. Mohawk - Loose 16-69; Grant Price 8-26; Gunnar Johnson 7-12; Stillberger 2-(minus 6).
PASSING: St. Joseph - Yeckley 9-16-0-151. Mohawk - Loose 1-11-1-25; Johnson 0-1-0-0.
RECEIVING: St. Joseph - Sessler 5-65; Jake Yeckley 2-30; Veleba 1-42; Kerr 1-14. Mohawk - Johnson 1-25.
"This one is for the kids. They've done all the work," St. Joe coach Scott Knisely said of the team's first outright MAL title since 1996. "To come back and win our last nine games and, more importantly, our No. 1 goal, win the league championship is special. It's been 15 years since we've won this and it's a very special thing to win."
Despite the margin of victory, however, the clincher wasn't all that easy to attain.
The Streaks scored on the game's opening possession when Yeckley tossed a sideline screen pass to Alex Veleba, who raced 42 yards for the touchdown and a 7-0 lead with 9:41 still to play in the first period.
The Warriors threw a counter punch but didn't quite make full contact.
Quarterback Drew Loose broke off a 39-yard run for a first down on the St. Joe 28. Loose and Grant Price traded shots into the line until the Warriors had a first-and-goal from the 6.
But the Streaks held their ground. St. Joe defenders had 13 stops for minus-yardage, including two on this opening drive. On fourth down from the 3, junior lineman Corey Durbin threw Loose for a 2-yard loss.
Mohawk didn't post a major threat again until late in the fourth.
"That was a very strong defensive stand, especially after we got some momentum by going down and scoring," Knisely said.
The Streaks grabbed a 13-0 lead at the half on Yeckley's 3-yard keeper with 6:14 to play. The score was set up by Yeckley's 25-yard screen pass to his brother, Jake.
"I thought in the first half, defensively, we were two plays from a shutout," Mohawk coach Erik Baker said.
But three big plays early in the second half allowed St. Joseph to gain control.
A moment after Mohawk's opening possession of the half stalled on the Streak 42, St. Joe running back Marcus Kerr shot through the line for a 55-yard touchdown. Kerr finished with 115 yards on 22 carries to go over 950 yards for the season.
The kickoff bounced off a Warrior front-liner and Ryan Williams recovered for the Streaks on the Mohawk 43. Three plays later, Yeckley tossed a short pass to Jordan Sessler, whose catch and run resulted in a 41-yard touchdown for a 26-0 lead with 5:30 left in the quarter.
The two scores came in a matter of 68 seconds.
"It's been a frustrating year," said Baker, whose club finished 3-7 overall and 2-5 in the league. "It always seemed like the other team was coming up with the big play when they needed it. There was a learning curve for us; we struggled with finishing."
Each team added touchdowns in the fourth quarter. St. Joe's came on Luke Stierwalt's 1-yard run to finish a 56-yard drive.
Mohawk's score came on Loose's 34-yard run to cap a 60-yard drive. Holder Logan Stillberger dropped the PAT snap, but improvised and ran around right end for a two-point conversion.
"If there is a silver lining to all this, it's that we played an awful lot of freshmen, sophomores and juniors and hopefully, they learned from the different things that happened to us this year," Baker said. "There is an awful lot of frustration.
"We've got to find a way to be in the weight room and get the most out of ourselves because that's what the people we play do," he said. "We weren't quite ready to compete sometimes from a physical standpoint. That's something we want to address."


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5 Tips for Punching Writer's Block in the Face
#2. Don't Get Ahead of Yourself
Digital Vision./Photodisc/Getty Images
Are you worried about marketing, promotion, or traditional publishing vs. self-publishing? There might be a more pressing issue you're forgetting about: Do you have a finished fucking book yet?
You'd be astounded how many requests for writing advice start out: "I'm going to write a book, should I self-publish? How do I get an agent?"
Self-publish what? Your good intentions? An agent for what? Your nebulous aspirations? You don't have anything yet!
You have a vague idea and an impulse. You might as well tell me you're thinking about grabbing a burrito, but you want to know which toilet you're going to crap it out into first. You're concerned with a hypothetical future, and that concern is actively preventing said future from happening. Even if you're just sitting there staring at a blank page, you're still being infinitely more productive than the writer who doesn't even have a word processor open yet. As human beings, we are all very stupid in the exact same way: We procrastinate, but we know procrastination is bad, so we try to spin the act into alternate methods of productivity.
Medioimages/Photodisc/Photodisc/Getty Images
"I know we have a big case to prep for, but this is relevant, I swear: Do you think you could kill an intern with a paper airplane?"
"I'm not putting off cleaning the garage; I'm just practicing the Swedish art of planed space arrangement first!"
"I'm not putting off my thesis; I'm just researching which fonts are most efficient at conveying numerical data in low light!"
"I'm not putting off writing my book; I'm just trying to figure out what demographics are most interested in purchasing erotic island-themed horror for the Nook first!"
Yes, what you are doing is, at first glance, slightly more productive than playing XCOM until your eyes bleed, but it's still not accomplishing the task at hand.
#1. Stop Worrying About Originality
Digital Vision/Digital Vision/Getty Images
You know what nobody's done before? A gender-bending mermaid story that takes place entirely in cyberspace.
You're right. Nobody has done that before. And there's a very good reason for it: TranSplash: Open Ports is probably going to be a terrible book just as soon as I'm finished writing it.
Most new authors are extremely worried about novelty. They don't want to write something that's been written before or, God forbid, be accused of ripping off some other book. But as counterintuitive as it sounds, originality should be your last concern. Virtually every story has already been told. All of the major arcs and plot structures are several millennia old, and if you squint hard enough, even Die Hard 4 is just a palette-swapped Beowulf. Unless it's The Epic of Gilgamesh, your favorite book is probably not the first to put its core concepts into words. Good books are not gauged by their novelty, otherwise the most successful modern novels would just be random pictographs and artfully smeared feces. Hey, nobody's done an anthology of "don't walk" signs and poo before -- sounds like a best-seller!
Andrew H. Walker/Getty Images Entertainment/Getty
"Like Fifty Shades of Grey, but with less crap!"
The problem is not uniqueness. It's earnestness. If you're worried that your pacing is too similar to Harry Potter, don't write it backward in a mirror; just try to be honest and respectful to your audience. If you're concerned that your main character is too similar to Italo Calvino's protagonists, you don't need to make your omniscient water molecule a midget, too. Just have the little dude speak with your voice, and tell any dissentin' bitches it was an homage. Nobody can dispute an homage.
That shit's like a literary force field.
Buy Robert's stunning, transcendental, orgasmic science fiction novel, Rx: A Tale of Electronegativity, right here. Or buy Robert's other (pretty OK) book, Everything Is Going to Kill Everybody: The Terrifyingly Real Ways the World Wants You Dead. Follow him on Tumblr, Twitter, and Facebook.

subset: commoncrawl


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Edited by Richard J. Hobbs and Katharine N Suding
New Models for Ecosystem Dynamics and Restoration, published in 2008, brings together leading experts from around the world to explore how conceptual models of ecosystem dynamics can be applied to the recovery of degraded systems and how recent advances in our understanding of ecosystem and landscape dynamics can be translated into concept... read more
By David J. Tongway and John A. Ludwig
Restoring Disturbed Landscapes, published in 2010, is a hands-on-guide for individuals and groups seeking to improve the functional capacity of landscapes. The book presents a five-step, adaptive procedure for restoring landscapes that is supported by proven principles and concepts of ecological science. The book is abundantly illustrated with photos and ... read more
By William R. Jordan III and George M. Lubick
Making Nature Whole, published in 2011, presents an in-depth history of the field of ecological restoration as it has developed in the United States over the last three decades. The authors draw from both published and unpublished sources, including archival materials and oral histories from early practitioners, to explore the development of the f... read more
By Andre F. Clewell and James Aronson
Ecological Restoration, published in 2008, offers for the first time a unified vision of ecological restoration as a field of study, one that clearly states the discipline's precepts and emphasizes issues of importance to those involved at all levels. In an engaging manner, the authors discuss the scientific and practical aspects of the field as wel... read more
Edited by Stephen Packard and Cornelia F. Mutel
The Tallgrass Restoration Handbook, published in 2005, is a hands-on manual that provides a detailed account of what has been learned about the art and science of prairie restoration and the application of that knowledge to restoration projects throughout the world. Chapters provide guidance on all aspects of the restoration process, from c... read more
By Michael L. Morrison
Restoring Wildlife, published in 2009, gives ecologists, restorationists, administrators, and other professionals involved with restoration projects the tools they need to understand essential ecological concepts, helping them to design restoration projects that can improve conditions for native species of wildlife. It also offers specific guidance and examples on how v... read more
Edited by Dave Egan, Evan E. Hjerpe, and Jesse Abrams.
Human Dimensions of Ecological Restoration, published in 2011, takes an interdisciplinary look at the myriad human aspects of ecological restoration. The book provides practical and theoretical information, analysis, models, and guidelines for optimizing human involvement in restoration projects. Six categories of social activities a... read more
Edited by Mary Doyle and Cynthia A. Drew
Large Scale Ecosystem Restoration, published in 2008, presents case studies of five of the most noteworthy large-scale restoration projects in the United States: Chesapeake Bay, The Everglades, California Bay Delta, the Platte River Basin, and the Upper Mississippi River System. These projects embody current efforts to address ecosystem restoration in a... read more
Edited by Edward O. Guerrant JR, Kayri Havens, and Mike Maunder
Ex Situ Plant Conservation, published in 2004, is the first book to address integrated plant conservation strategies and to examine the scientific, technical, and strategic bases of the ex situ approach. The book examines where and how ex situ investment can best support in situ conservation. Ex Situ Plant Conservation outlines t... read more
Edited by Vicky M. Temperton, Richard J Hobbs, Tim Nuttle, and Stefan Halle
Assembly Rules and Restoration Ecology, published in 2004, offers an introduction, overview, and synthesis of the potential role of assembly rules theory in restoration ecology. It brings together information and ideas relating to ecosystem assembly in a restoration context, and includes material from a wide geographi... read more
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Top Definition
Paintball played on flat, open ground. The field contains inflateable barricades ("bunkers") that are made up of the same material as river raft boats. They come in various shapes, from cylinders to triangles, and are generally named after whatever they look like, e.g "Tea bag" "Coke can" "Snake". Fields are almost always symetrical along the width axis.
"The tournament was all sup'air, but the layout on field 3 sucked"
"The sup'air field over there looks like a fun one to play"
"The sup'air field over there looks like a fun one to play"
από Jon S 15 Δεκέμβριος 2003
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People Exclusive
Eva Longoria Has a New Boyfriend, Is Not Dating Eduardo Cruz
A source exclusively tells PEOPLE that the 38-year-old actress has been dating "a wealthy, successful businessman from Mexico."
The budding romance has left the former Desperate Housewives star feeling quite blissful these days.
"She's very happy, and he's crazy about her," the source adds.
Longoria, who split from entrepreneur and onetime Ready for Love bachelor Ernesto Arguello in August, is not ready to reveal the identity of her new boyfriend, the insider says.
Just last week, reports surfaced that Longoria had rekindled her relationship with erstwhile flame Cruz after the two supposedly had a cozy lunch together in New York City, according to eyewitnesses.
Call it a case of mistaken identity: The source close to Longoria says that the actress "was not dining with Eduardo in New York" but was actually having a lunch date with her new man.
Both Longoria and Cruz later took to Twitter to deny the alleged Manhattan rendezvous.
"Sorry this is just not true," wrote Longoria, who included a link to a news story about her supposed lunch hookup with Cruz.
For his part, Cruz Tweeted, "Mmmmm ... Nope ... In San Francisco with my Girl Friend," and attached a photo of a car cruising down a mountainside road.


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Top Definition
Firthing is the act of hanging around the object of your affections looking intense but never actually telling them how you feel. The term is named for Colin Firth who played Mr. Darcy in a film adaption of Pride and Prejudice and spent a lot of time "firthing."
Rather than just tell her crush how she felt, Rebecca chose instead to spend the entire party firthing in his general vicinity.
автор: m1thrand1r 27 августа 2013
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on December 2, 2012 - 3:14 PM
A Buffalo News distribution center at 1800 Broadway was burglarized late Friday or early Saturday, Ferry-Fillmore District police reported today.
Regional manager Scott Moreland said an office door was pried open, and the intruder smashed four computer monitors, a keyboard and two doors. Ninety boxes of delivery bags, worth $31 each, were missing.
A hammer's head was found at the scene and collected as evidence, police said.


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Full CoverageBreaking News
Judge restricts cellphone use for man accused of posing as news photographerUPDATED 12:04 PM EST Nov 20, 2012
A man who allegedly posed as a news photographer and tried to meet up with high school girls appears in court, where a judge places restrictions on who he can call.
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CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Neil Patrick Harris just sold his Sherman Oaks, California, home after a bidding war, TMZ reports.
The How I Met Your Mother star put the house on the market for $2.9 million last week, receiving multiple offers above the asking price, according to the Los Angeles Times.
The 4,191-square-ft. abode boasts six bedrooms, four-and-a-half baths and a park-like backyard with a pool, built-in pizza oven and outdoor shower.
In an unusual move for a celeb listing, the property was featured as an open house, and hundreds turned up to check it out, the Times reports.
Harris, 41, purchased the home four years ago for $2.1 million. He's shared the house with partner David Burtka, 39, and their 3½-year-old twins, Gideon and Harper.
The family relocated to the East Coast as Harris took a Tony-winning turn in Broadway's Hedwig and the Angry Inch.
See pictures (all taken by photographer Brandon Vogts) of Harris's simply elegant home, below.
Brandon Vogts Photography
Brandon Vogts Photography
Brandon Vogts Photography
Brandon Vogts Photography


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Retro tourism poster from the 1950's [we think] promoting Denmark as a tourist destination. Using that quintessential icon of Danishness - Woman on Bike. Once again, once again... it's not just us. We are merely continuing a century long tradition with this blog. The child's seat in the artwork is still in use today. Great to have the kid up front as opposed to sitting on a plastic contraption behind you.
And while we're on this retro journey, here's a film still from Hitchcock's 'Topaz', filmed in Copenhagen and, not surprisingly, featuring a girl on a bike.


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Quality Education in the Benedictine Tradition
Nov. 19, 2012
Saint Vincent College will present eight upcoming planetarium shows in the Angelo J. Taiani Planetarium and Astronaut Exhibit in the Sis and Herman Dupré Science Pavilion on the campus of Saint Vincent College. Admission is free and open to the public. The one-hour shows, all scheduled to begin at 11 a.m., include late fall sky and Dynamic Earth, Saturday, Dec. 8; The Star of Bethlehem Christmas Show, Saturday, Dec. 22 and Jan. 5; winter sky and Oasis in Space, Saturday, Jan. 12; winter sky and Two Small Pieces of Glass, Saturday, Feb. 9; early spring sky and Oasis in Space, Saturday, March 16; spring sky and Two Small Pieces of Glass, Saturday, April 13; and spring sky and Dynamic Earth, Saturday, May 4.
They are conducted by one of the faculty members in astronomy from the College's Department of Physics, Dr. John Smetanka or Dr. Daniel Vanden Berk. Selected deep sky objects – star clusters, nebula and galaxies – will be viewed along with simulated trips to planets and moons in the solar system. All shows except Dec. 22 and Jan. 5 will end with a 25-minute theatrically-produced full-dome immersive video. A second, 30-minute show appropriate for children age 3 to 10, The Sky Over Mr. Rogers' Neighborhood, will be presented at 12:30 p.m. on each date except Dec. 22 and Jan. 5. The show will explore the sky with Mr. Rogers and the animated characters from the land of make believe. Because of limited seating, advance reservations are requested and may be made by contacting the Herbert W. Boyer School of Natural Sciences, Mathematics, and Computing at 724 805-2631. Private shows for groups of 15 to 35 people may also be scheduled at other times by contacting the Boyer School. Scout groups who wish to fulfill requirements for merit badges are especially encouraged to make appointments. The Angelo Taiani Planetarium and Astronaut Exhibit is the centerpiece of the glass-walled atrium entrance to the Dupré Pavilion. The state-of-the-art planetarium was made possible by a gift from Angelo Taiani, a 1948 graduate of Saint Vincent who enjoyed a successful career as an aerospace engineer with the National Aeronautics and Space Administration. Taiani wanted the new planetarium and exhibit to bring recognition to the nation's space program and serve Saint Vincent students as well as the western Pennsylvania area and beyond. Space exploration will dominate our nation's future. NASA's goal is to go to Mars as soon as a new launch vehicle can be developed, perhaps as early as 2020. It is hoped that this new facility will help Saint Vincent students as well as young area students get excited about the importance of interplanetary space exploration and the career opportunities available in this field. One of the objectives of space exploration is the search for extraterrestrial life and that exploration will eventually discover planets like the Earth, light years away where life may exist. Taiani, a native of Latrobe and a graduate of Latrobe High School, served three years in the Navy during World War II and retired as a Navy Commander with 41 years of reserve service. He first became interested in aerospace when he was assigned to work with early guided missiles and space ordnance as a project officer for the first ten Jupiter launches. He returned to Saint Vincent and graduated with a bachelor of arts degree in chemistry from SVC in 1948. He also did graduate study at George Washington University. He worked on numerous projects at NASA as a general space engineer, in test support at Cape Canaveral and later the Kennedy Space Center on the Juno project. He also worked in support of the Space Shuttle program. He retired in 1984 after a 34-year career with the space agency. He still lives in Cocoa Beach, Florida, and enjoys volunteering to give tours of NASA facilities to journalists. He has known many of the astronauts, from Buzz Aldrin to Alan Poindexter, and has been an avid collector of photographs of the astronauts and launchings. Many of these have been given to Saint Vincent for display in the planetarium. The planetarium projector system was purchased from the Spitz Corporation, based in Chadds Ford, Pennsylvania, a leader in planetarium technology. The planetarium features the latest digital technology that can not only project the nighttime sky but can also take viewers on a tour of the solar system.
Follow us on Twitter: @SVCPublicity Like us on Facebook: Saint Vincent College Public Relations


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They offer an unprecedented window into the life of one of Hollywood's biggest stars: court documents filed in Tom Cruise's $50 million lawsuit against Bauer Publishing for cover stories claiming he "abandoned" his daughter Suri after splitting with Katie Holmes in June 2012.
But now one of the most sensational revelations in a deposition that surfaced earlier this week has been amended by the star himself.
In the original documents, Cruise was grilled about why he didn't see Suri for more than 100 days after his headlining-making breakup.
Under questioning by the company's attorney, Elizabeth McNamara, the actor divulged that the 7½-year-old was no longer practicing Scientology, and seemed to concede that his church was a major part of the reason that Holmes ended their marriage after six years.
"That was the assertion, yes," the star said in response to the lawyer's question about whether Holmes left because she wanted to protect their daughter because of the controversial religion. "There were many other aspects to the divorce."
But in a document filed on Nov. 5, Cruise returns to the exchange and amends his words, telling the court, "Katie has never told me that this [Scientology] was a reason for our divorce."
Reps for both Cruise and Holmes – who took Suri to South Africa with her while she shoots a movie – aren't commenting on the legal back-and-forth.
But it's clear that Cruise wants to underline that Scientology did not come between him and his daughter – a point he repeatedly makes in the original deposition, calling the assertion "absolutely disgusting."
Tom Cruise: Katie Holmes Never Said Scientology Was a Factor in Divorce
Jean-Paul Aussenard/Wireimage


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As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
NSCLC is "Major Battlefield" as Merck,...
The current approach to drug development has not served the industry well. Fewer drugs are being approved, even as R&D investments spiral upward. The long-accepted protocol of in vitro testing of compounds followed by in vivo animal studies appears to be less satisfactory than in the past at predicting efficacy or toxicity. The changing picture is, no doubt, a reflection of the complex nature of drug targets.
An alternative to the traditional drug development protocol, however, has been maturing. The rise of computer technology, combined with a more sophisticated attack on targeted diseases, could eliminate unsatisfactory candidates early in the game, providing the possibility of vast savings and a new round of innovative therapeutics. Yet, numerous challenges remain, as was discussed at CHI's "BioIT World" meeting held recently.
"The systems biology approach allows us to map out the pathology of a complex condition and discover drugs that will treat the underlying disease," said Jordi Naval, Ph.D., research scientist at Anaxomics Biotech (www.anaxomics.com). Using algorithms that address multifaceted relationships within metabolic pathways, it is now possible to hone in on previously unrecognized drug targets.
The company uses existing databases to create cellular roadmaps to build discovery platforms. These databases employ text mining to define interactions within metabolic routes and signaling pathways. According to Dr. Naval, "we start with the seed interactome, that is, the set of already identified proteins that participate in the disease, and use this as the framework for constructing our model."
Dr. Naval and his colleagues take advantage of a large coterie of databases, including Entre Gene and Unipro, to look for possible targets. Building on the seed interactome they seek an expanded understanding of the target pathway. Promising leads are then validated in the laboratory using standard technologies for studying gene expression, such as the yeast two hybrid system, site-directed mutagenesis, and cellular and animal models. This expanded knowledge allows an exploration of perturbations of the system, which the company has pursued for the tumor necrosis factor pathway.
Qingyu Cao, Ph.D., head of business development at AlgoNomics (www.algonomics.com), presented her company's approach to dealing with immunogenicity of therapeutic proteins. As all therapeutic proteins demonstrate some level of immunogenicity, this is a common problem.
AlgoNomics' Epibase® uses structural bioinformatics to identify potential epitopes on a protein based on the structural characteristics of HLA molecules and their binding property to epitopes. The whole sequence of target protein is scanned using the Epibase algorithm, and the binding affinity between epitope and HLA is computed based on the interaction energies, taking into account side-chain flexibilities. A risk profile of the particular protein molecule is thus provided. This method becomes increasingly more accurate as the amount of experimental data grows, correlating in silico modeling with results from the company's T-cell activation assay.
While the in silico approach cannot replace thorough animal and clinical studies, it allows for a more rapid and accurate assessment of the immunogenicity risk and can provide substantial cost savings by elimination of blind alleys, Dr. Cao reported.
Dr. Cao's contentions were buttressed by clinical data from a study on patients with rheumatoid arthritis who were receiving Adalimumab directed against TNF-a. The study, performed in collaboration with Sanquin and Genmab, identified a number of potential troublemaker epitopes.
Of 109 patients enrolled in the study, 19 showed antidrug antibodies and 17 of these possessed HLAs that were targeted by unruly epitopes. These HLAs are also highly associated with RA.
While high-throughput screening is now widely employed in the search for new pharmaceutically active molecules, there is little information available on the factors that affect the ability of positive hits to move to later stages of drug development. Novartis Pharma (www.novartis.com) has extensive experience in this area, according to Andreas Bender, Ph.D., post doctoral fellow at the Novartis Institutes for BioMedical Research.
Dr. Bender's approach is to combine in silico target prediction, which gives mechanistic information about compound action, with cellular, image-based readouts profiling multiple parameters, yielding holistic information but lacking the mechanistic parameter. "We combine both processes to have a better of idea of the true character of a compound, in order to measure both the effect of a compound as well as to develop an hypothesis of its function," he stated.
Dr. Bender and his associates compared the results of thousands of high-throughput screening runs using 15 different readout technologies and 18 target classes including protein kinases and GPCRs. The group collected data on which aspects of the screening process were empirically correlated with downstream success, defined as the fraction of HTS campaigns that advance into the later stages of drug discovery.
The Novartis high-content screening platform gives 36-dimensional readouts in three channels. HeLa cells are grown for 24 hours, stained with a laundry list of fluorescent dyes, then analyzed by automated microscopy following a factor analysis to reduce dimensionality of the readout. This approach yields a multidimensional readout that details the assembled complexity of the signaling network. "We can build statistical ligand-target relationships to predict the targets of molecules, based on their molecular structure," Dr. Bender said.
When Dr. Bender and his colleagues analyzed the results of these large-scale screens of 6,500 compounds they found that "similar effects (phenotypes) can be obtained from dissimilar molecular structures. On the other hand, similar structures can cause dissimilar effects. Different information is obtained from both sources and employing both types of knowledge is crucial."
Vitae Pharmaceuticals (www.vitaepharma.com) is one of a number of companies assessing low-molecular weight compounds as inhibitors. The company has targeted renin because, as Suresh Singh, Ph.D., director of computational drug design, explained, the renin-angiotensin system is essential for regulating vascular function.
The company's drug discovery platform, Contour™, was designed to create thousands of novel molecular structures through visualizing the most relevant potential inhibitors. The program starts with a defined active site on a target to which an anchor fragment is fitted; other fragments are added stepwise until a molecular weight limit is reached. The in silico molecule is given a final score and saved as one of thousands of different candidate structures that are assembled using high-speed computers.
According to Dr. Singh, Vitae scientists have used the top scoring conformations to build two series of potent and selective inhibitors. In less than 18 months they were able to construct candidates with patentable design, high potency, and bioavailability, all of which demonstrated blood pressure lowering ability in a number of different species. The company is moving its renin inhibitors toward clinical evaluation and also pursuing a number of other disease targets.
These targets include 11b HSD-1, an enzyme critical in the production of cortisol that has been implicated in diabetes and cardiovascular disease. Yet another program targets the Aurora A and Aurora B serine/threonine protein kinases, which are overexpressed in many human tumors.
Vitae is also developing orally active inhibitors of BACE1 (b-site APP cleaving enzyme 1) for the treatment of Alzheimer's disease and low molecular weight inhibitors of the enzyme HCV NS3 protease for HCV treatment.
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I am writing in response to Neil Rudel's criticism of Matt McGloin's post-game comments where his passionate critique of the official's blunder on the PSU touchdown drew the ire of some reporters.
I am a PSU season ticket holder. But I am also an official in both football and college basketball, and I don't have a problem with Matt's comments.
His clear implication is that PSU is still being punished after the Draconian NCAA sanctions.
The replay, from every angle, established one thing - McGloin had reason to feel frustration. The ruling was wrong. The replay official on Fox, Mike Pereira, opined that it should have been reversed. The broadcasters for PSU, Nebraska and ABC all confirmed it was a touchdown. Nebraska fans on the PSU websites wrote it was a touchdown.
Yet, Rudel said the ball "seems to have broken the plane of the goal line." Actually, when the ball breaks the plane, by rule, that's a touchdown.
Rudel is correct that the error did not cause the Lions to lose the game. Quite frankly, the way Nebraska played in the second half, I'm sure they would have marched down the field, with the wind at their back, and scored at least a field goal, or even a touchdown in the last seven minutes. Both teams surely would have played differently and maybe - just maybe - PSU might have won the game. I don't know, but it would have been nice to watch.
But for Rudel to criticize McGloin's reaction right after the game is a bit hypocritical. To complain that his passionate comments are out of line, yet love every second of it because he gives you a headline story, is rather insincere.
If reporters don't want honest and emotional reactions, why interview the players after the game? McGloin is a sports writer's dream. He will tell you exactly how he feels without a filter, just like another fiery Scranton Irishman, Joe Biden. And I think he said what most PSU fans were thinking.
I am not a conspiracy theorist. I don't believe Big Ten officials are conspiring against Penn State, nor do I believe that Joe Paterno conspired with other PSU administrators to protect a pedophile and themselves from bad publicity.
But based on the perceived rocky relationship between PSU and the Big Ten, I can understand how fans would think Jim Delany has sent specific instructions to the game officials. Actually, there are plenty of facts to justify an opinion that PSU is getting screwed from referee calls than evidence that Paterno was involved in a conspiracy to avoid bad publicity. Just look at the game films from this year, be it against Northwestern, Ohio State or Nebraska.
PSU has had calls go against them in the past plus, let us not forget, it was largely PSU's complaints regarding the bad officiating in big games that the Big Ten has instant replay. So I guess it's a bit ironic that the instant replay official that PSU championed to correct wrongs in big games let them down.
We can't count on anyone, even the ones we should be able to count on. Whether it be officials who are supposed to follow the rules, or the NCAA which is supposed to follow their bylaws, or PSU administrators who are supposed to champion and defend the PSU community. We have been failed by each one of them.
I would love to see Bill O'Brien listen to that little devil on his right shoulder rather than the angel on the left and tell us what he really thinks of the officiating. He has done a fabulous job under unprecedented conditions, and I respect his decision to remain diplomatic, but you can tell he wants to explode.
So it's refreshing that we now have a kid who says enough is enough.
Jim Elliott
Conspiracy at work?
I would think it is just bad officiating, but this run seems so peculiar for its onesidedness, if that is a word.
Since Big Ten officiating is so bad in general, it makes it hard to dismiss the non-conspiracy thought process.
When I think back to the ridiculous calls against PSU in the Ohio State game, however, (the "hold" on a punt and Mauti being mugged and taken down while Braxton Miller ran past him), and the fact that I read that no PSU league opponent has been called for offensive holding in the last 17 quarters, the mind does get to wandering into the realm of conspiracy theories.
Who ever thought with sanctions just beginning we would still see such passion from the fan base? I never doubted the players' passion. This is a special group, and it has been fun to watch.
Kevin Murphy
Gaithersburg, Md.
Big Ten against Penn State
PSU has been getting shortchanged on calls the entire season, and I believe the Big Ten officials have been directed to make calls to keep PSU from winning close games that matter for other Big Ten teams.
Let's face facts here: The holding on the punt call against OSU was terrible, not to mention Mauti being tackled by an OSU lineman prior to Braxton Miller diving into the end zone and the numerous non-calls for holding and pass interference during that game.
Even the announcers stated that OSU was getting away with an awful lot of holding. As for the call against Nebraska, I think it was terrible. Clearly the ball crossed the goal line, and both of Matt Lehman's hands had it secure.
I can understand the officials on the field missing a bang, bang call, but there is no excuse for the replay booth to uphold the call unless they have been directed to do so or the review official was an ex-Nebraska player/alumni.
These poor young men go out and play their hearts out every week and have not done a thing wrong, and it surely seems like they are being overly penalized for the actions of a sick man in Jerry Sandusky.
Hopefully, coach Bill O'Brien will take up this issue with the Big Ten commissioner and head of officials at the end of the season so we can move forward in a fair and unbiased environment.
Throw a few of those calls that OSU gets our way once in awhile.
Dennis Reed
Fairborn, Ohio
Disappointed in coaching
Well, I believe the honeymoon with Bill O'Brien is over. Penn State made no adjustments at halftime either on offense or defense against Nebraska or Ohio State.
Bo Pellini and his Nebraska coaches figured out Penn State's so-called New England Patriots style of offense. Meantime, defensive coordinator Ted Roof once again showed he is not the guy to shut down offenses run by a dual-threat quarterback. We saw that with Ohio University, Ohio State and now Nebraska.
To add to insult, Big Ten referees have stunk since Penn State joined the Big Ten. Tight end Matt Lehman broke the end-zone plane before he fumbled. But the Big Ten reviewing official saw exactly what he wanted to see. And quarterback Matt McGloin played his typical game against a better team.
When this season is over, it will go down as 7-5 as most pundits felt before the season started.
And this might be the best team for a long time with the sanctions. O'Brien and his coaches have a lot of serious thinking to do this winter.
Les Hart
Ideas for a mountainous league
This letter is in regards to Charlie Weston's guest column in the Mirror on Oct. 28 about a high school sports realignment in central Pennsylvania.
I have a suggestion: I'd like to see a new Mountain League, featuring competitive and same-sized schools, which should add more fan interest and shorten travel distance.
Possible members could include:
Class AAAA - Altoona, State College, Williamsport, Central Mountain, DuBois and Mifflin County.
Class AAA - Hollidaysburg, Bellefonte, Clearfield, Indiana, St. Mary's, Bradford, Johnstown, Punxsutawney.
Class AA (large division) - Central, Tyrone, Huntingdon, Philipsburg, Bald Eagle, Bedford, Juniata.
Class AA (small division) - Penns Valley, Chestnut Ridge, Mount Union, Everett, Bellwood, Ligonier Valley, Southern Huntingdon.
This realignment would be good for all sports.
Don Mingle
Roaring Spring
Area golf clubs appreciated
As a second-year high school golf coach blessed with good players and fortunate enough to advance to the PIAA championships this year, I've come to appreciate what many do not see in this process - the hard work, dedication and sacrifice of several local golf clubs to make all this possible.
I therefore wish to publicly recognize the following golf courses for their participation in the playoff events, which ultimately culminated with the state championships at Heritage Hills Golf Course in York.
Those courses include Summit Country Club in Cresson for hosting the District 6 sectional tournament, Scotch Valley Country Club in Hollidaysburg for hosting the District 6 tourney and Tom's Run Golf Course in Blairsville for hosting the regionals.
The high school playoffs are not only disruptive to these clubs' membership but also costly financially as each club donates their course free of charge for the one-two day event.
These clubs, their staffs, members and governing boards should know their generosity for providing top notch and challenging venues, and for being so gracious and accommodating to the players, coaches, and family members who participated in this year's events is appreciated.
Tom Aurandt
Golf Coach
Central Cambria High School


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You know exercise is good for you, but do you know how good? From boosting your mood to improving your sex life, find out how exercise can improve your life.
Want to feel better, have more energy and perhaps even live longer? Look no further than exercise. The health benefits of regular exercise and physical activity are hard to ignore. And the benefits of exercise are yours for the taking, regardless of your age, sex or physical ability. Need more convincing to exercise? Check out these seven ways exercise can improve your life.
Exercise can help prevent excess weight gain or help maintain weight loss. When you engage in physical activity, you burn calories. The more intense the activity, the more calories you burn. You don't need to set aside large chunks of time for exercise to reap weight-loss benefits. If you can't do an actual workout, get more active throughout the day in simple ways — by taking the stairs instead of the elevator or revving up your household chores.
Worried about heart disease? Hoping to prevent high blood pressure? No matter what your current weight, being active boosts high-density lipoprotein (HDL), or "good," cholesterol and decreases unhealthy triglycerides. This one-two punch keeps your blood flowing smoothly, which decreases your risk of cardiovascular diseases. In fact, regular physical activity can help you prevent or manage a wide range of health problems and concerns, including stroke, metabolic syndrome, type 2 diabetes, depression, certain types of cancer, arthritis and falls.
Need an emotional lift? Or need to blow off some steam after a stressful day? A workout at the gym or a brisk 30-minute walk can help. Physical activity stimulates various brain chemicals that may leave you feeling happier and more relaxed. You may also feel better about your appearance and yourself when you exercise regularly, which can boost your confidence and improve your self-esteem.
Winded by grocery shopping or household chores? Regular physical activity can improve your muscle strength and boost your endurance. Exercise and physical activity deliver oxygen and nutrients to your tissues and help your cardiovascular system work more efficiently. And when your heart and lungs work more efficiently, you have more energy to go about your daily chores.
Struggling to fall asleep? Or to stay asleep? Regular physical activity can help you fall asleep faster and deepen your sleep. Just don't exercise too close to bedtime, or you may be too energized to fall asleep.
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Exercise and physical activity can be a fun way to spend some time. It gives you a chance to unwind, enjoy the outdoors or simply engage in activities that make you happy. Physical activity can also help you connect with family or friends in a fun social setting. So, take a dance class, hit the hiking trails or join a soccer team. Find a physical activity you enjoy, and just do it. If you get bored, try something new.
Exercise and physical activity are a great way to feel better, gain health benefits and have fun. As a general goal, aim for at least 30 minutes of physical activity every day. If you want to lose weight or meet specific fitness goals, you may need to exercise more. Remember to check with your doctor before starting a new exercise program, especially if you haven't exercised for a long time, have chronic health problems, such as heart disease, diabetes or arthritis, or you have any concerns.
Original article: http://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/exercise/art-20048389
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Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised.
A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.


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Jan Mursak/ Merged
Posted 03 October 2010 - 07:20 PM
Mursak is a gem, been saying it for years. Very dynamic hockey player.
Ken Holland: Hes (Mursak) a young guy, provides energy, can skate, hes a puck hound.
Posted 05 October 2010 - 11:57 PM
Posted 29 October 2010 - 05:35 PM
GRAND RAPIDS -- Jan Mursak doesn't particularly enjoy speaking to the media after practice or games.
He prefers to let his play do the talking.
"I'm normally a pretty shy person, especially when I have to talk," Mursak said. "English is not my first language. I got better at it, I'm a little more comfortable talking."
Truth be told, the 22-year-old Slovenian's English is just fine. But it's his output on the ice that might get people talking.
Mursak leads the Grand Rapids Griffins with four goals and is tied for first with seven points through the season's first seven games.
The forward also owns a four-game point streak that is one shy of his career high.
Mursak, who was drafted 182nd overall in the 2006 NHL draft by the parent club Detroit Red Wings, is looking to take another step in his development after last season's drastic improvement.
After recording only two goals and seven assists in 51 games during his rookie year, Mursak's production jumped to 24 goals (second on the team), 18 assists and a plus-12 rating in 79 games last season.
"I've had a pretty good start. The years before, I had a slow start, nothing went my way really," he said. "But this year, it looks like pucks are going in.
Mursak, who was a point-per-game player for two years in the Ontario Hockey League, said he wasn't as prepared as he should have been when he made the leap to the American Hockey League in 2008.
"I didn't know about the 80 games, bad road trips. I don't think I was mentally and physically ready for all that," he said. "But I was working extra hard in the summer and got way stronger in the gym, and I think it's paying off so far."
Griffins coach Curt Fraser wasn't surprised Mursak jumped out to a strong start.
"That's what we expect out of him. Remember, the first year with this kid, he had chances every night he played, but he couldn't find the back of the net," Fraser said. "But he didn't stop working, off the ice and in the gym. He didn't let things bother him, he just kept moving forward."
Mursak's biggest asset always has been speed, which helps him create scoring chances even on the penalty kill. His two short-handed goals are tied for the league lead this season.
The biggest knock has been his size and strength, but Mursak (5-foot-11, 192 pounds) worked with a trainer this summer to ensure that area no longer is a concern.
If he continues to flash a deft scoring touch, Mursak might even earn his first NHL call-up later this season.
"I think I'm making smarter plays, I'm hanging onto the puck a little longer. I used to get rid of it pretty quick my first year, even last year," he said. "This year, I'm trying to perfect it better and kind of thinking before I do stuff, 'What am I going to do?' It's a good thing.
"During the season, we learn new stuff. You see what plays you can make, what's good, what's not good. I think I still have a lot to learn."
As long as Mursak continues to work hard, Fraser will reward him with ice time.
"I don't bench anybody," Fraser said. "I just go with the guys that are going."
E-mail Michael Zuidema: firstname.lastname@example.com and follow him on Twitter at twitter.com/michaelzuidema
Posted 09 December 2010 - 08:28 AM
"Mursak's goal was...you know...will be on the highlight tape for the year...great goal".
Edited by Aussie_Wing, 09 December 2010 - 08:31 AM.
Ken Holland: Hes (Mursak) a young guy, provides energy, can skate, hes a puck hound.
Posted 09 December 2010 - 10:07 AM
Posted 09 December 2010 - 10:22 AM
Well for now you can be content with listening to it.
Whoa... I need to see this goal. Like now.
My link
Edited by Aussie_Wing, 09 December 2010 - 10:22 AM.
Ken Holland: Hes (Mursak) a young guy, provides energy, can skate, hes a puck hound.
Posted 09 December 2010 - 06:40 PM
Well for now you can be content with listening to it.
My link
I appreciate the efforts man. It's just not the same.
Posted 09 December 2010 - 06:55 PM
At 2:36
Posted 09 December 2010 - 08:13 PM
Heck of a play between those two though, and the finish at high speed by Mursak with a defender right on his tail, excellent stuff. These two really are great prospects.
It's a nice goal. Way overblown in my mind but still a good goal. I mean, damn, it was like Helm a guy with real solid finishing ability. To be honest, I'm a little more impressed with the pass by Tatar. But that's just me and I'm a passer when I play.
At 2:36
Ken Holland: Hes (Mursak) a young guy, provides energy, can skate, hes a puck hound.
Posted 10 December 2010 - 10:57 PM
To me what is impressive is the fact that Mursaks knock in the past was his strength but on that play he had a guy draped over his back yanking at him and he still buried.
It's a nice goal. Way overblown in my mind but still a good goal. I mean, damn, it was like Helm a guy with real solid finishing ability. To be honest, I'm a little more impressed with the pass by Tatar. But that's just me and I'm a passer when I play.
At 2:36
Posted 27 January 2011 - 01:15 AM
Mursak played in 14 games and impressed coach Mike Babcock with his speed and competitiveness.
"Hes earned our confidence," Babcock said. Theres two parts of it. Not only do you have to believe you can play, we have to think you can play. And we believe that. His speed is a huge asset, he seems to have good hockey sense, he seems to know how to play with and without the puck. Hell be an NHL player."
Posted 27 January 2011 - 09:53 AM
I LOVED reading that, brought a big smile to my face. I've been so impressed with him during his stint, he played so well again last night, should've had an assist on a Franzen blown chance. He is so, so strong along the boards, he always wins battles sheerly because of his intensity and desire. He's going to be a very good player for this organisation.
Ken Holland: Hes (Mursak) a young guy, provides energy, can skate, hes a puck hound.
Posted 27 January 2011 - 01:48 PM
HankthaTank - Squirrels, they hate to be thrown. / Why is the magical unicorn named Brian... Jedi - I just downloaded the "kids" book, "Go the F--k to Sleep" as narrated by Samuel L. Jackson on my kindle. I am now ready to be a daddy. / *Checks Router* No, I'm positive I didn't hit the "Wings Defense Sucks" button. Electrophile - I'm just glad the Wings were able to win despite the Curse of Brian. ACallToArms - I think Trey needs to put something about payroll tax and deferred income in his sig... Edicius - I'd rather [have] a soundbite of me saying "I like (man sausage)" rather than "I like Crosby".
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Individual applications are reviewed on the basis of a student's potential for success at Westminster. Academic preparation, which includes both coursework and grades, is most important. Also important to the review are items such as entrance exams (ACT or SAT), recommendations, and extracurricular activities. A campus visit to meet with an academic counselor is recommended, as it helps complete the picture for both the prospective student and the college.
A student currently enrolled in high school may be accepted for admission on the basis of six semesters of high school work. The college may require additional grade reports during the student's senior year, and will require final transcripts showing high school graduation.


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Musicians' crazy backstage requests
POSTED: 08:51 AM PDT Sep 08, 2011 UPDATED: 10:00 PM PST Feb 22, 2011
Beyonce is currently on a world tour and a supposed tour rider has leaked revealing some pretty interesting demands. Check out these odd requests from famous musicians and performing artists.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


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No butts about it: Ellen DeGeneres is a real crack-up!
The talk show host revealed her very cheeky costume during Wednesday's Halloween-themed episode of The Ellen DeGeneres Show, dressing up as Modern Family star Sofia Vergara, whose slinky green Zuhair Murad gown infamously split along her rear during the Emmys.
"I am easy breezy beautiful CoverGirl from Colombia. Happy Halloween. As you can see, I put my pumpkins out," DeGeneres, who is also a CoverGirl, said, affecting Vergara's accent. "I get so much work with this fake accent," she added.
But the comedienne was interrupted by the real deal when Vergara made an appearance, bluntly telling DeGeneres, "Your ass looks huge."
"I have to say, it is looking in a mirror," DeGeneres told Vergara, who called the costume, "ridiculous."
In true Ellen style, DeGeneres replied, "I feel sexy," before the two bombshells started dancing.
Ellen DeGeneres Dresses Up as Sofia Vergara for Halloween
Michael Rozman/Warner Bros.


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Article Archive:
Legally Speaking- The right to go from point 'A' to point 'B'
By Bob Mionske
Posted Sep. 2, 2004
Dear Bob,(
I am curious what you think of the recent Toronto court decision thatthe City of Toronto owed cyclists a duty of care to maintain a safe cyclingenvironment.(
N.D.(, Colorado
Dear Bob,(
The main highway in our area is scheduled for repaving. This will closeone side of the divided including both shoulders for a ten-mile stretchover a six-month period. The section is used by hard-core commuters andis a popular ride for those who want to get out of town for the weekend.What are the contractor's obligations to accommodate bicycle traffic? Whatare my rights when a "bike lane closed sign is encountered" on a commute?(
Dear N.D. and J.M.(
First, let's look at the Toronto Case. Several of you have emailedme about this suit, Hannah E. Evans v. City of Toronto. It was aheard in a Toronto small claims court (File No. T64013/02),had no written case findings issued, and was not appealed. Because it washeard in small claims court and was issued with only an oral opinion, thereis no "precedent" and nothing for lawyers or other judges to consult—thecomments of the judge, if any, were simply the opinions of one court. Theinternet commentary on the case can be tracked back to a single source,an expert witness in the case who filed an affidavit largely based on the1999 version of the Guide for the Development of Bicycle Facilities, publishedby the American Association of State Highway and Transportation Officials(AASHTO).
The Constitutional "right to travel" is a funny creature. Everyoneknows it exists, but no one seems to know where—it is not explicitly stated,and one federal judge found that at one time or another, the Supreme Courthad attributed seven different clauses of the constitution as the sourceof that right. To make things even more complicated, the 'right of travel"really isn't a right of travel—it is more accurately described as a rightof migration from one state to another without interference. However, ina 1972 Pennsylvania case involving a teenage "cruising" ban, a federaljudge said that there truly is such thing as "the right to go where youwant:"
Travel by a particular mode of conveyance, however, is a different story.In 1978, cyclists in Omaha, Nebraska sued the Nebraska and Iowa highway departments because they closed three of the four bridges across the MissouriRiver to cyclists. In the case, Wherrett v. Doyale, the cyclistsargued that many of them had to go miles out of their way to get back andforth between Omaha and Council Bluffs, and in the event of an accidentor construction on the fourth bridge, they would have no access at all.The court was unsympathetic:
The court went on to say that even if travel by a single mode were constitutionallyprotected, all that would be required of the highway department would bea showing that the ban was "rationally related" to protecting the safetyof cyclists on unsuitable roads. (I have a second-hand report that ajudge in Ontario in 1991 rejected this same argument, noting that banningcyclists because the road was too dangerous for them "was the ultimateexample of the legal tail wagging the dog." However, I have not been ableto find this Canadian case. If any of our colleagues north of the borderhave any leads on this, I would appreciate an e-mail.)
A logical retort would be "is the same true for cars?" Yes, single-modetravel by automobile is not constitutionally protected. The issue has beenused (unsuccessfully) to fight the suspension of drivers' licenses by thosecollecting too many moving violation "points."
On the other hand, ten year later, a New York judge, in Kaehny v. Lynn,threw out an injunction prohibiting the city's DOT from closing the bikelanes on the Queensboro Bridge for most of the day to facilitate construction.Unlike the Madison Avenue case, the DOT already had statutory authorityto close vehicle or bicycle lanes:
And unlike Messenger Services, the judge in this case was willing to confrontthe constitutional issues the cyclists raised. The outcome was not pretty:
One of the most unusual cases in the history of bicycle law similarly occurredin New York, in 1991, and also involved the bike lanes on the Queensborobridge. (People v. Gray et al) To facilitate the flow of motor vehicles,the city moved bikes from a dedicated lane to the sidewalk, using the formerbike lane for traffic, and opened a tightly-spiraled access ramp formerlyused only by bikes to mixed traffic. Transportation Alternatives, a localadvocacy group, protested and blocked the former bike lane. After beingarrested, they dispersed without incident. At trial, they pled not guiltyto disorderly conduct by reason of necessity, claiming their action wasnecessary to prevent a greater evil. The judge explained their defense:
And the judge bought it!(
Good luck- Bob(
(Research and drafting assistance provided by Bruce Epperson J.D.)
Bob Mionske is a former competitive cyclist who representedthe U.S. at the 1988 Olympic games (where he finished fourth in the roadrace), the 1992 Olympics, as well as winning the 1990 national championshiproad race.After retiring from racing in 1993, he coached theSaturn Professional Cycling team for one year before heading off to lawschool. Mionske's practice is now split between personal-injury work, representing professional athletes as an agent and other legal issues facing endurance athletes (traffic violations, contract, criminal charges, intellectual property, etc).If you have a cycling-related legal question, please send it to firstname.lastname@example.com Bob will answer as many of these questions privately as he can. He willalso select a few questions each week to answer in this column. General bicycle-accident advice can be found at www.bicyclelaw.com.
Important notice:
The information provided in the "Legally speaking"column is not legal advice. The information provided on this publicweb site is provided solely for the general interest of the visitors tothis web site. The information contained in the column applies to generalprinciples of American jurisprudence and may not reflect current legaldevelopments or statutory changes in the various jurisdictions and thereforeshould not be relied upon or interpreted as legal advice. Understand thatreading the information contained in this column does not mean youhave established an attorney-client relationship with attorney Bob Mionske.Readers of this column should not act upon any information contained inthe web site without first seeking the advice of legal counsel.
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on November 7, 2012 - 12:15 AM
The Bonnies got the stop and defensive rebound they needed. Trailing by a point with 22 seconds left in the game, they brought the ball up the court. Jim Crowley passed on calling a timeout, letting the game unfold for his players. With 5.2 seconds left, Jordan McGee got the ball. She had been just 1 for 2 in her 29 minutes of action, but stepped in and confidently nailed a 15-foot jump shot.
The other team called a timeout but a scrambling defense prevented them from getting a good shot, securing an exhibition win.
Welcome to St. Bonaventure women's basketball, where success is built on talent, teamwork and a flair for the dramatic.
And while McGee's shot was the game-winner, there isn't a member of the program, including McGee herself, who would single out one person in a win. It doesn't even take one person to get a rebound in the Bona system of basketball because in all likelihood, the woman who gets credited with the stat was the beneficiary of another player having her back.
For four years, the St. Bonaventure women have been a success story. It started with Dana Mitchell, who had her number retired after guiding the Bonnies to their first ever postseason event - the WNIT. Next up was a senior class anchored by guard Jessica Jenkins and forward Megan Van Tatenhove. That group led the Bonnies to their first national ranking and to the Sweet 16.
Who's got next for the Bonnies?
This year, the leadership comes from senior guard Alaina Walker, junior guard CeCe Dixon and junior forward Doris Ortega.
OK you three. Whatcha got?
While they don't have all the answers they have a thorough understanding of what it took to win in the past and what they need to instill in this group to continue the legacy.
"Last year we knew who could produce," Ortega said. "This year, everybody's learning what they can do. It's more intense and locking in. It's a challenge, but I'm ready for it."
"It's new roles but we just learn to embrace it," Dixon said. "Communication is key and going hard all the time. You've got to be prepared to take shots and go hard."
"It's a learning process," Walker said. "We have to teach the younger girls what we have learned. It's a slow process, but they're understanding."
That process got a bit more difficult early in preseason when senior Chelsea Bowker suffered a broken ankle. She will redshirt this season and return for her final year of eligibility next year. Bowker wasn't just ready to step into a more prominent role of the floor but also in vocal leadership on a team that graduated some very strong personalities.
Just when the group left behind had started to feel comfortable in their new roles, down goes Bowker and the roles changed again.
"We had the returning group ready to take on new roles and they did an amazing job over the summer," Crowley said. "Chelsea had kind of established that. She was going to be the on-the-floor leader. She was primed for a really good year. So now all of a sudden it changes ... and we're still figuring that out. It's all kind of coming together but it's going to take time. We're going to take some lumps. We know that. Our kids know that. It's the reality. I think our kids have always been pretty good at understanding who we are, who we could be and what we need to do to get there. I think we can be OK as the year goes on."
Don't expect another NCAA tournament run from the Bonnies this season. The program's success is built largely around effort and defense and that effort and defense are built on trust. With six freshmen on the roster, trust doesn't develop overnight. Crowley is also aware that his freshmen may suffer a bit from "deer in the headlights" syndrome that's understandable when joining a program that went to the Sweet 16 last season.
But through these years of 20-plus wins and postseason tournament appearances, the Bonnies have never really talked much about their triumphs. They just focus on what they can control and let everything else fall into place.
"We never talked about our success last year," Crowley said. "In all these years we never talked about needing to get this win or that win. When we retooled things, I made a decision there were only a couple of things that mattered to me. Then it was really what did the kids expect. What could the kids realistically expect and then what would they invest to get there. That's how we tried to handle it. ... All that matters at the end of the day is did we play hard? Did we play for one another? If those things stay consistent, the other stuff takes care of itself."
email: email@example.com


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Press Release
Earnings from presentations of Schindler's List on June 23 and 26 will benefit
Spielberg's USC Shoah Foundation
Plano, TX - Cinemark Holdings, Inc. (NYSE: CNK), one of the world's largest motion picture exhibitors, is pleased to announce the next four films in our Classic Series will feature the works of acclaimed director Steven Spielberg. The films include JAWS on June 2 and 5, RAIDERS OF THE LOST ARK on June 9 and 12, E. T. THE EXTRA-TERRESTRIAL on June 16 and 19, and SCHINDLER'S LIST on June 23 and 26. Performances will be on Sundays at 2pm, and Wednesdays at two separate show times, 2 pm and 7pm.
All earnings from the June 23 and 26 performances of SCHINDLER'S LIST will go to Spielberg's USC Shoah Foundation - The Institute for Visual History and Education, which is dedicated to making audio-visual interviews with survivors and witnesses of the Holocaust and other genocides a compelling voice for education and action.
"Steven Spielberg's work as a director is unparalleled. But as a humanitarian and through his endeavor with the Shoah Foundation, his work takes on new breadth and depth. Cinemark is proud to present his films on the big screen, and to partner with his charity by donating all proceeds from SCHINDLER'S LIST," states James Meredith, VP, Head of Marketing & Communications for Cinemark Theatres.
Individual tickets, or a specially priced bundled package of $20 for Cinemark's Classic Series, are now available at www.cinemark.com or at the participating theatre box office. For a full list of participating Cinemark locations, advance ticket purchases and show time information go to the Cinemark web site.
Ranked at number 56 on the American Film Institute's 100 Greatest Movies of All Time, JAWS is the film credited with creating the summer blockbuster. The 1981 RAIDERS OF THE LOST ARK, ranked 66 on AFI's list, was a collaboration between Spielberg and George Lucas. His follow-up in 1982, E.T. THE EXTRA-TERRESTRIAL, became the highest grossing film of all time and is ranked number 24 on AFI's list. SCHINDLER'S LIST, ranked number 8, was Spielberg's first film to win him an Academy Award for Best Director. All told he has been nominated for the award seven times and won twice (SCHINDLER'S LIST and SAVING PRIVATE RYAN).
Cinemark is a leading domestic and international motion picture exhibitor, operating 467 theatres with 5,259 screens in 39 U.S. states, Brazil, Mexico, Argentina and 10 other Latin American countries as of March 31, 2013. For more information go to www.cinemark.com.


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Topic: Id help for Concentric Paperweight (Read 3159 times)
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Posts: 2384
Re: Id help for Concentric Paperweight
Reply #10 on:
January 26, 2012, 10:01:57 AM »
Hi Roger
You have hit the nail on the head when you say âI am odd with coloursâ. That is one of the several majors problems with UV fluorescence as a diagnostic tool â different people see colours in different ways; it is a subjective assessment. I disagree with my wife about what is blue or what is green when we get to colours near âturquoiseâ. So descriptions such as âpale straw with a hint of pinkâ are probably more appropriate to the catwalk than to paperweight attribution. There are some significant differences between paperweights that most people would agree on, but you have to be very careful with interpretation.
The best way to study fluorescence would be to get a source of precisely known wavelength(s) â not just from some âblack lightâ made for security, philately, or mineraology â and a spectrometer to allow quantitative measurement of frequency and intensity of fluorescence. But that is beyond most - if not all â collectors, unless they work in a relevant research lab.
Much detailed scientific work on fluorescence was carried out by an American professor (Woldemar Weyl) in the 1960s for the glass industry. He found that the glass composition and trace elements affected fluorescence â as one would expect â but that other factors such as the annealing process and the gas composition in the glory hole also affected it. I recall a paperweight meeting at which Dave Moir brought along several one-off weights he had made at Strathearn â the results of the UV tests led him to be assured that they had been made at more than one factory, whereas the UV differences were probably a result of variations in the manufacturing process.
One paperweight book says (and it gets repeated as if true) that most antique Saint-Louis weights fluoresce âcoral pinkâ. Mine donât â but that probably means we used slightly different illumination for the tests. I remain to be convinced that many of the results of UV testing are meaningful.
"There are two rules for ultimate success in life. Number 1: Never tell everything you know."
The comments in this posting reflect the opinion of the author, Alan Thornton, and not that of the owners, administrators or moderators of this board. Comments are copyright Alan Thornton.
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Posts: 5408
Re: Id help for Concentric Paperweight
Reply #11 on:
January 26, 2012, 06:33:24 PM »
Roger, thanks for your confirmation about having both longwave and shortwave uv lights. The "pink" part of your "light green with a hint of pink" may be a result of reflection of the glow of the uv bulb!
And thanks to Alan for the comments about problems with uv analyses, for which I will add something below.
However, your "lght green (smoky)" could tie in with what I see as "dusty grey". If that is true then I am happy enough that your weight is not from Vasart Ltd (i.e. 1956-64) or Strathearn (1964-80). Are you able to adequately separate "greens" and "blues"? If so, the quite strong blue under shortwave uv of Vasart Ltd & Strathearn would be clearly noted. If that is not the case for your weight then I would say it is not from those factories.
But in my experience, weights from the Moncrieff and Ysart Brothers factories have pretty much the same longwave reaction and also much the same for shortwave reaction. So it cannot be said that uv reaction can specifically indicate Moncrieff, as it could equally be Ysart Brothers (or even other factories, UK and elsewhere).
I have found that although difficulties occur with assessment of many uv reactions, in a number of cases the reactions are so different as to be a good indicator even if the actual colour or shade is not always easy to determine, or to agree person to person. It is the
clear differences
that help to a large extent with Ysart and similar weights. And it is the clear differences, not the alterantives in shades of colour, that I use to determine the likelihood of a Vasart Ltd or Strathearn weight as opposed to one made at the Moncrieff or Ysart Brothers works.
Alan is quite right that there are many difficulties with uv analyses. In 1969, Paul Hollister Jr. warned about the problem in his book,
The Encyclopedia of Glass Paperweights
where he commented on different colours seen for weights from known factories, whereas various people had assumed certain colours meant certain factories (such as "Pink / Peach" for St Louis). At that time the analyses were done with only longwave uv., but in the book, the actual wavelength was not stated (as far as I can see), nor details of the type of lamp used.
For the record, all of my analyses of Ysart and similar weights have been done with a mains operated unit (230 volt, used with UK 240 volt system) and having dual bulbs, longwave (365 Nm) and shortwave (254 Nm).
Another point that Hollister made was that, as an artist, he was well aware of the effect that one colour could have on an adjecent colour. Without going into detail, I can confirm that when I photographed weights under uv light, using one weight as a standard control with the analysed weight adjacent to the control, I occasionally noted that the control weight showed as a noticeably different shade! Hollister's comment may well expalin this.
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Roger H
Posts: 424
Re: Id help for Concentric Paperweight
Reply #12 on:
January 26, 2012, 11:17:54 PM »
Interesting and complex subject. See what you mean I think, if kept to the main definite colours it can be very useful for ID but if taken to shades of colours it could be misleading because of other factors needing to be in the equation, like uv light type, the persons perception of colours, surrounding colours and so on.
My wife often says "its reflecting off the colours in the weight also".
I can differenciate quite easily between blue and green but when it gets to turquoise then it becomes difficult to agree with my wife on the colour. Even some blues I can see a warm blue which means to me it has 1 or 2% red in the mix.
Last time I looked Simons weight was doing quite well on the auction, I'll have a look in a minute. Will say simons weight is better made than mine, but I like the orange crunchie base colour in mine.
Roger( the revisionist).
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Roger H
Posts: 424
Re: Id help for Concentric Paperweight
Reply #13 on:
January 29, 2012, 10:10:06 PM »
Well somebody bought it at all costs, its a nice weight but it would have to be signed and dated for that price for me. Would anybody like to buy one similar with an orange crunchie ground?
Roger (the realist).
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Posts: 68
Re: Id help for Concentric Paperweight
Reply #14 on:
February 12, 2012, 02:23:38 PM »
I have a Paul Ysart scramble paperweight which has a not too dissimilar bubbly ground...
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Re: Id help for Concentric Paperweight
Reply #15 on:
February 12, 2012, 05:19:12 PM »
Simon, why do you belive the scramble weight is one of Paul's?
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Re: Id help for Concentric Paperweight
Reply #16 on:
February 13, 2012, 08:47:49 PM »
Hi Kevin - I think my scramble weight is by Paul largely because its similar design is similar to those ascribed to Paul in books. I haven't been able to cane match, but no canes immediately jumped out to me as Salvador canes, or even Ysart Brothers. (I've handled a Salvador/YB scramble in the past, and it was very different.)
Here are a few more photos
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Re: Id help for Concentric Paperweight
Reply #17 on:
February 14, 2012, 12:12:08 AM »
Thanks for the additional photos, Simon. I agree - no "Salvador canes" that I can see, so I agree it's one of Paul's.
The yellow ground does show some bubbles (holes), which is something I hardly see at all in my own PY weights. But the bubbles/holes are not as extensive as in Roger's (*) example.
(*) I suppose I should now say "my example" as it was me who pressed the button on Roger's eBay listing.
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Re: Id help for Concentric Paperweight
Reply #18 on:
February 14, 2012, 12:30:05 AM »
And now that I have the weight that Roger showed, I can add a photo of it against another "holed-ground" weight I have. The weight shown against the ex-Roger one has an orange ground almost the exact shade of the other and although it does not show too many obvious holes from the top view, the oblique view photo does make it clear.
The canes in the "Catherine wheel" design weight can all be matched to other Salvador / Ysart Brothers work and the design has been seen in at least three Inkwells of the typical Salvador/Vasart type and at least two other weights. (That design, however, was not generally known until a few years ago when all the items seemed to almost appear at once! But they are all genuine, so no worries there.)
I have also added another weight with a bubbled/holed orange ground (albeit a much darker orange). This, of course, is a Roundels design and having no outer cane between the roundels is a Salvador version.
From this evidence, I vote strongly for Salvador Ysart as the maker of the ex-Roger weight and also of Simon's weight which kicked off this thread. ... Oh, and one other thing ...
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Re: Id help for Concentric Paperweight
Reply #19 on:
February 14, 2012, 12:47:52 AM »
... I will now admit to having a weight that I have not shown publicly since I bought it. It came from the USA, via eBay some years back. From the top view, it shows basically the same pattern as in Simon's and the ex-Roger weight. But check out the side view - it is the only one I have seen like it! I have been waiting for something similar to appear but so far it has not.
Perhaps this domed example was a forerunner to the standard millefiori version of that pattern. Or maybe it was just a whimsical variation at much the same time as, or even later than, the others?
The canes in the outer row have suffered a lot of movement in the section shown in the side view photo. The large central (top) cane is one of the so-called Salvador ones. The yellow cane with black centre is an example of those found in items by both Paul and Salvador. The powdered green element is unusual as it is used solely as a "side" decoration - the actual regular ground is a very powdery looking white.
The pontil scar does tend much more towards Salvador as the maker and the powdery white ground adds to that as, so far, I have not seen it used by Paul but it is known in several pieces by Salvador, including an Inkwell that was very recently sold on eBay.
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