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on November 14, 2012 - 10:03 PM
David A. Smith, the Niagara Falls man accused of plowing his motorcycle into several pedestrians on an Amherst bike path, killing two people, was charged with drunken driving in Florida in 2010 – five years after being released from probation for a drunken driving conviction in North Tonawanda.
The Florida charge, however, was dropped, and related traffic violations were dismissed, possibly because of an error police made in filing the charges, according to court records.
Smith was pulled over because he was driving his Harley-Davidson motorcycle erratically, with a radio blasting, in Volusia County, near Daytona Beach, on March 4, 2010, according to Florida police reports. Smith refused to take a Breathalyzer or blood test to determine his blood-alcohol content, according to arrest records. When the case went to court, it was found that the arresting officer wrote the wrong statute when filing the careless-driving charge, resulting in that charge, and the loud music charge, being dismissed, according to court records. The drunken driving charge was then dropped.
But because Smith refused to take the Breathalyzer or blood test, he was banned from driving in Florida for a year, and was assessed a $175 fee. The fee was never paid, so Smith is still forbidden to drive in Florida, according to the Florida Department of Highway Safety and Motor Vehicles. Smith's Florida arrest occurred five years after he was released from probation for being convicted of DWI in North Tonawanda. He pleaded guilty to felony DWI in October 2000 in North Tonawanda, court records show. He was fined $2,500 and sentenced to five years' probation. At one point, he was sent to jail for 30 days for violating his probation.
Computer records also show Smith was convicted of DWI in a 1997 incident on Grand island.
But Smith's New York driving record is currently clean, according to the state Department of Motor Vehicles. Drunken driving convictions are removed from a driver's record after 10 years in New York State.
While Smith is not facing felony DWI, the criminally negligent homicide charge lodged against him is a felony. Smith, 53, was driving drunk, police said, when he veered off Tonawanda Creek Road at about 3:20 p.m. Sunday and into a group of pedestrians on the Amherst bike path. Jocelyn B. Elberson, 25, of the Town of Tonawanda, and Sheila Pelton, 81, of East Amherst, were killed. Smith is being held at Erie County Holding Center without bail.
email: email@example.com


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Watch more Sex Scene Vidio Videos, share videos and find the latest funny videos at Viduu.
- Some guys have a Dukes of Hazard replica car and decide to recreate a famous scene.
- A scene from Old School (best college party movie ever) where Old Blue wrestles two topless girls in KY Jelly. (Nudity Warning)By: nearlygood l Tags: old school, scene, topless, wrestling, oil
- Apparently there were some deleted scenes in the Matrix that happened to be gay.
- Here's some video of the Dutch Hardcore scene. This is some pretty cool music and looks like a lot of fun.
- This is one of the funniest scenes in this movie. Everyone sitting around the poker table talking sex. **Offensive language**
- Olivia Wilde nude sex scene with Emile Hirsch in Alphadog. Olivia Wilde gets completely naked in the film Alphadog.By: nearlygood l Tags: olivia wilde, nude, naked, topless, boobs
- Hilarious spoof of a scene in Mission Impossible 3 from MTV done by Jessica Alba, Flava Flave, and Topher Grace.By: nearlygood l Tags: mtv, spoof, mission, impossible
- Angelina Jolie getting nailed in this hot sex scene.By: nearlygood l Tags: angelina jolie, sex scene, celeb, naked
- Here is a deleted scene from Star Wars where Alison Angel gets her boobs out for R2 D2.By: nearlygood l Tags: alison angel, boobs, topless, star wars
- This is a deleted scene from season 6 of Family Guy where Joe is training the people of Quahog to answer 911 calls.By: nearlygood l Tags: family guy, 911 call, joe swanson
- In this clip Jennifer Aniston is topless during a sex scene in the film The Good Girl. We get a nice glimpse of her nips.By: nearlygood l Tags: jennifer aniston, topless, sex scene
- Hot actress Christina Hendricks sex scene from US TV show Mad Men.By: nearlygood l Tags: christina hendricks, sex scene
- Amber Heard is a very hot actress, she's been in films like Zombieland, Never Back Down and The Joneses. This sex scene is from The Informer, enjoy.By: nearlygood l Tags: amber heard, sex scene, naked, celebrity
- Angelina Jolie shows off her boobs in this nude shower scene from the film Mojave Moon.By: nearlygood l Tags: angelina jolie nude, naked, boobs
- Demi Moore shows off her naked body in this sex scene with Woody Harrelson in Indecent Proposal.By: nearlygood l Tags: demi moore, sex scene
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subset: commoncrawl


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The Auburn University Journal of Undergraduate Scholarship (AUJUS)
The AUJUS is a peer-reviewed journal that showcases the top research and scholarly accomplishments of Auburn University undergraduate students. We are seeking original research from students in any academic discipline. Submissions are due in early September of every year. The AUJUS is faculty-reviewed and peer-published with its student editors. The AUJUS is an interdisciplinary partnership with the Graphic Design department and the Office of University Writing.
The next deadline for AUJUS submissions will be January 2017. To be considered for inclusion in the 2017 print version of the AUJUS, articles and highlights must have completed the review and revision phases and been accepted by January 2017. Check back in Fall 2016 for the deadline.
To have copies of the AUJUS placed in your department or office, please contact our office at firstname.lastname@example.com.
Last Updated: March 30, 2016


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Top Definition
The cross between a merman and a goat. Mer-goats were bread for Circus Acts. However, the two entities combined created an insanely high energy "animal", if you will. Now no one can catch the fuckers!!! They run like a mexican from the police! Moving on- This particular breed can live in the water and on land, making it one hell of a mission to try and find. If you see Krystle then most likely a mer-goat is close by. The two have been inseperable since the days of wizards and trailer parks.
Wanna go with my uncle to hunt for Mer-goats this summer? We will bring a 12 gauge!
di skeet:skeet 21 marzo 2007
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European Association of Tissue Banks - Statement on the issue of value added tax (VAT) for human tissues and cells
24th Congress of the European Association of Tissue Banks
October 1-3, 2015
Split, Croatiawww.eatb2015.eu
Report on the 7th World Congress on Tissue Banking - (1,22Mb)
World Congress on Tissue Banking 2014
Notify Project - Download pdf (2'55Mb)
Pictures EATB 2013: 22nd Annual Congress of the European Association of Tissue Banks, November 20-22, Brussels, Belgium
Trafficking in organs, tissues and cells and trafficking in human beings for the purpose of the removal of organs - Joint Council of Europe/United Nations Study
Global initiative on Eye-Bank terminology- Download Press Release
President's Welcome
I am delighted to welcome EATB members and visitors to the EATB website. The EATB is an advocate for its members in all medical, scientific and other professional activities associated with tissue banking. This website is designed to help communication between EATB members, the EATB Board, Sister Associations and other professionals with an interest in this field. The website has public pages and pages dedicated to the interests of members of the EATB. If you wish to join the EATB you are invited to complete an application form, which can be downloaded here
The EATB has many diverse functions:
Ruth Warwick
EATB President (2007 – 2009)
On behalf of the EATB Board


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|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
Fellow Otakus,Thanks for all your posts. We're psyched to see the Manga community grow and have the honor of providing a spot for you to chat about what we all dig. We want to remind you to please post in related topics. This makes it easier to for fellow users to find/explore the topics they're looking for. Site News & Announcements is really for us, (i.e., the Manga Team) to let you guys know what's up with the site, the service or exciting news regarding Manga.com.Thanks again for exploring your fandom with us! Yours in the cause,The Manga Team
Can we please get a section where we can just talk to each other about anything? 92% of the teenage population would be dead if Ambercrombie and Fitch or Hollister said it was uncool to breathe.
"You will See, in Time you shall walk the same path as I"
"people do not need violence to solve there problems."
An off-topic board. "What do you see in front of your fists?"
We get off topic anyway and it is just fun to see where the coversation goes. "You will See, in Time you shall walk the same path as I"
All of the topics are open to users. We're just asking users not to post in the Site News & Announcements since the admins use that to post important announcements on the site. Keeping it relegated to that makes it easier for other users to find actual "Site News". Again, the rest of the topics are open for use. Thank you.
The Manga Team
tru goin threw the forums you see some pretty random stuff 麿 情意 法則 俗世 けつの穴 穴凹
hi what's up can u add me to your profile pleaz ok i want to be your friend
Yes, a general discussion section would be great and help the forums grow.
i hope it grows more i know ani-monday helps
your welcome im glad that i can help..


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Top Definition
A dance manoeuvre made famous by the Hertfordshire-based band Enter Shikari, initially found in the music video for the song Destabilise and further displayed at live shows, in which lead singer Rou Reynolds, guitarist Rory Clewlow and bassist Chris Batten simultaneously bounce from left to right in a stationary position whilst keeping their legs pressed together.
Everybody was doing the Shikari Shuffle shuffle at the gig last night, it was nuts!
av Johnny'Sniper 11. juli 2011
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Source: Fierce Wireless
quote: RIM tried to sell itself and had no buyers
quote: RE: total pwnage of micktroll and retrotroll is getting closer!
quote: It was widely reported
quote: they really dont compare well against the latest round of 5 inch 1080p Android phones
quote: so does WP8 and no-one is buying it
quote: Lets wait for real reviews
quote: Do you have some market share #'s that show it gaining?
quote: I need more res to make it so I dot have to scroll up and down to see every window I open. You wouldn't understand.
quote: my point with that is MS isn't doing too well in the mobile sector
quote: you don't even know the basics of smartphone tech


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Our Approach
We pride ourselves on having the ability to handle complex family law litigation without losing sight of the smaller, emotionally-fraught details that often mean the most, at the end of the day, to the people we represent.
Practice Areas
The firm's family law practice encompasses divorce, child custody/parenting time, child support, paternity, legitimation, pre and post nuptial agreements, separate maintenance and modification and enforcement of those issues.
Consultation & Fees
The purpose of an initial consultation is to provide you with a level of comfort and knowledge as to how Georgia law may apply to your particular domestic situation and what you may expect throughout the process. Please see "Initial Consultation" under our FAQs section for additional information.
Find answers to the questions that are most frequently posed by our clients who are encountering family law issues.
KS Family Law is very proud and excited to announce the pubication of "A CUP OF COFFEE WITH 10 OF THE TOP DIVORCE ATTORNEYS IN THE UNITED STATES" co-authored by Marvin Solomiany
Randall M. Kessler
Founding Partner
Mr. Kessler is a past Chair of the Family Law Sections of both the American Bar Association and the Georgia State Bar. But his true passion is representing individuals in family law matters and he has been doing that since he started practicing law in 1988. He founded the firm in 1991 and has built it into one of the most respected family law firms in the country based on the quality of the firm's legal work and service to its clients.
Marvin L. Solomiany
Managing Partner
Mr. Solomiany, a fellow of the American Academy of Matrimonial Lawyers and a past Chair of the Atlanta Bar Family Law Section, has worked as a trial attorney exclusively in the area of family law for over 15 years. He provides representation in all areas of the firm's practice, with an emphasis on high-income divorce cases, prenuptial agreements, interstate child support and custody matters, and those involving corporate entities. Mr. Solomiany has represented athletes, entertainers, professionals and executives from Fortune 500 Companies throughout his career and is a frequent lecturer in both state and national family law seminars.
Karine P. Burney
Ms. Burney received her J.D. from Loyola University-Chicago School of Law in 2005. Since 2006, Ms. Burney has exclusively practiced in the area of family law handling complex divorce cases, child custody issues, support and alimony claims, modification actions, prenuptial agreements, and all other domestic relations matters. Ms. Burney is certified as a Collaborative Law attorney and was an instructor in the Kennesaw State University Paralegal Certificate Program from 2007 through 2012. Ms. Burney has been recognized as a Georgia Super Lawyers, Rising Star. She is a Barrister in the Charles Longstreet Weltner Family Law Inn of Court, and the Co-Founder and Editor of The Cobb Family Law Quarterly, the Official Publication of the Cobb County Family Law Section.
Michael D. Deeb
Mr. Deeb is a graduate of The University of Georgia (BBA Finance) and Georgia State University College of Law (JD/MBA). During his time in law school, Mr. Deeb gained valuable legal experience clerking for the Honorable Alford J. Dempsey of Fulton County's Superior Court, and also working as an intern with the United States Department of Justice, Office of the Trustee. Most recently, Mr. Deeb worked as an intern with Kessler & Solomiany during his final two years of law school, prior to accepting a full-time position as an Associate with the firm. Mr. Deeb graduated with honors from both his JD (cum laude) and MBA (magna cum laude) programs, and brings a business-oriented perspective to the firm, having experience working with a vast array of complex financial documents.
Sean M. Ditzel
Mr. Ditzel, a recipient of Super Lawyer�s Rising Star designation, has worked as exclusively in the area of family law since his graduation from The University of Georgia School of Law. His practice includes all areas of family law including divorce, legitimation, paternity, adoption, modification and contempt actions. Mr. Ditzel has handled many high-income and high-profile clients throughout his career, and is an active member and leader in several local and state-wide bar associations.
Lindsay B. Dodson
Ms. Dodson is an associate with the firm and is a member of the Family Law Section of the State Bar of Georgia. Ms. Dodson has a broad range of experience representing and advisingclients in contentious and complex litigation related to divorce, alimony, child custody and support, separate maintenance, post-decree modification and enforcement, family violence , paternity and legitimation. Ms. Dodson has worked exclusively in the area of family law for over 6 years. Prior to joining the firm of Kessler & Solomiany in 2011, Ms. Dodson practiced family lawwith the firm of Weinstock & Scavo, P.C. Ms. Dodson received her J.D., with Honors, from Emory University, where shegraduated in the top 10% of her class and was inducted into the Order of the Coif and the Order of Barristers. Ms. Dodson was also the 2005 Emory University School of Law recipient of the International Academy of Trial Lawyers Award for Distinguished Achievement in the Art and Science of Advocacy.
Steven Kirson
AV rated by Martindale Hubbell. Practice family law in the major metro-Atlanta counties and also throughout Georgia. Extensive mediation experience, collaborative process experience. Represent individuals from initial consult and retainer through settlement or trial in divorces ranging from uncontested to complex/involving high net worth. Significant portion of practice includes alimony, child support, support or custody modification, contempt and related matters as well as QDRO preparation in addition to divorces. Prepare Prenuptial and postnuptial agreements, and litigate re: enforceability of such agreements. Utilize financial services industry experience to guide client financial advice and case strategy..
Robert B. Miller
Mr. Miller began his legal career at Kessler & Solomiany as an intern while attending law school. After graduating, Mr. Miller worked as a Clerk at Kessler & Solomiany until taking a full-time associate position at a prestigious family law firm in Atlanta. In 2012, Mr. Miller returned to Kessler & Solomiany bringing with him a wealth of knowledge in matters related to divorce, child support, child custody, legitimation, paternity and adoption. Mr. Miller is extremely active in the Atlanta legal community and he is a member of the Young Lawyers Division and Family Law Section of the State Bar of Georgia. Mr. Miller graduated from California State University, Fullerton earning his B.A. and M.A. in History, with an emphasis in modern Germany and Holocaust studies. Mr. Miller subsequently earned his J.D. from Atlanta's John Marshall Law School, where he excelled academically and was an active member in student government. Mr. Miller and his wife, Jessica, make their home in Sandy Springs with their son, Harrison.
Wayne Morrison
Of Counsel
Mr. Morrison grew up in Manassas Virginia. Before relocating to Georgia to attend law school and practice law he worked as Financial Analyst preparing, analyzing, and auditing financial statements. Mr. Morrison is experienced in handling complex divorce cases, child custody matters, support and alimony claims, modification and contempt actions, prenuptial agreements, and all other domestic relations issues. Prior to joining Kessler & Solomiany, Mr. Morrison was a founding partner at Hedgepeth, Heredia, Crumrine & Morrison and was a partner at Davis, Matthews & Quigley.
Louis J. Tesser
Mr. Tesser is a partner in the firm and a seasoned trial attorney of over fifteen years. He has been a general litigator, a prosecutor, and for the past nine years, has focused strictly on matrimonial law. Mr. Tesser is Vice Chair of the DeKalb Family Law Bar Association, and a Member at Large of the Atlanta Bar Association Family Division Executive Committee. He has spoken and taught frequently on topics in family law to diverse audiences, covering such matters as arbitration, paternity, divorce, and attorney�s fees. He is a certified mediator and arbitrator. Mr. Tesser is married to Lilia Tesser and lives with her and their daughters. Mr. Tesser enjoys tennis, travel, and is a private pilot.
Thad F. Woody
Mr. Woody has extensive experience representing clients in matters relating to divorce, child support, custody, legitimation and paternity. He has successfully represented a variety of clients including notable entertainers, athletes and high-profile executives. Mr. Woody is trained as a Guardian ad Litem and has performed substantial pro bono services on behalf of the Atlanta Volunteer Lawyers Foundation. He has also contributed to several seminar programs sponsored by the American Bar Association and the State Bar of Georgia. Mr. Woody received his bachelor of arts and juris doctor degrees from the University of North Carolina at Chapel Hill.
Quick Links
- Practice Areas
- Fees and Consultation
- Attorneys
- Collaborative Law
- Divorce
- Child Support
- KS Child Support Calculator
- Custody
- Prenuptial Agreements
- Client Forms
- Initial Consultation
- Blogs
- Awards
- Presentations
- Lectures
- Family Law Review
- Fulton Family Court
- Directions - Main Office
- Directions - Satellite Office


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Ken Bain, author of "What the Best College Teachers Do" will be on campus February 18. Dr. Bain is the Vice Provost for Instruction at Montclair State University. In this capacity he is the director of the Research Academy for University Learning, an innovative project for MSU to engage faculty into all aspects of student learning through discussion and research. The focus is to treat learning of students as an object of scholarly inquiry.
While on campus, Dr. Bain will conduct a morning workshop, have lunch with last semester's book study group, and have informal discussions with faculty in the afternoon.
To reserve a place on his schedule, contact Betsy Price by email or phone 956-882-7334.
The University of Texas at Brownsville website uses Javascript.
To access this page as it is meant to function please use a Javascript
enabled browser.


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ROCKFORD — Amanda Michalsen of Rockford was named to the fall 2013 dean's list at William Woods University.
To be named to the dean's list, a student must be full-time and earn a minimum 3.6 semester and cumulative grade-point average on a 4.0 scale.
For information: williamwoods.edu.
Location, ST | website.com


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Our Talent Network is a great way to learn about life at AT&T, straight from the source. Sign up and you'll receive a monthly newsletter and be the first to know about career events, new openings and exclusive updates. You'll even get job info that matches your skills, delivered right to your inbox. The best part is, just for signing up you'll have the chance to win this month's prize.
*Legal residents of the US only
Enter to win this month's prize
The 3D Blu-ray Disc® Player with Built-in WiFi.
Unleash the power of your TV.
Join the Talent Network to win an 3D Blu-ray Disc® Player with Built-in WiFi.
Want to be the first to know about our job updates, events and related news? Connect to AT&T Careers through our social tools.
At AT&T, we're doing great things every day. Explore our career possibilities to find out how you can get involved.
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Join our Talent Network to receive job-related info, news and updates straight from the source.
Find out what working here is all about
Get the scoop on what's happening right now
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Note: This message is displayed if (1) your browser is not standards-compliant or (2) you have you disabled CSS. Read our Policies for more information.
Last Updated April 2, 2012
Additional information is now available for use in figuring the student loan interest add-back.
Any required add-back will be the difference between the refigured deduction and the student loan interest deduction as reported on your 2011 federal income tax return, Form 1040, line 33, or Form 1040A, line 18.
Add the difference back on Schedule 1, line 7 (if filing Form IT-40), or on Schedule B, line 5 (if filing the Form IT-40PNR). Indicate the add-back by using code 128.
*The reduced phaseout ranges for the 2012 tax year and beyond are $50,000 to $65,000 ($75,000 to $90,000 for joint returns).


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An academic report from RMIT University School of Economics, Finance and Marketing provides extensive evidence that the corporate income tax system is not 'broken' and that it is not being eroded.
Commissioned by ACCA (the Association of Chartered Certified Accountants), the report Multinational corporations, stateless income and tax havens asserts that there is no evidence to support the belief that that UK or the US corporate income tax base is being worn away.
The report also states that advanced economies face a fiscal challenge, which creates the environment for a 'tax grab'.
Sinclair Davidson, author of the report and professor at the School of Economics, Finance and Marketing at RMIT, says: 'The argument is that the corporate income tax base is being eroded by aggressive tax planning by multinational corporations – yet the evidence to support this argument is lacking. It is one thing to point out that multinational corporations do not pay tax in some jurisdictions but that says nothing about the actual corporate income tax base. To the extent that corporate income tax revenues have fallen in recent years, this is more likely to be a result of poor economic conditions than aggressive tax planning.'
Chas Roy-Chowdhury, head of taxation at ACCA, comments: 'This paper may well show that the global corporate income tax system is not broken, but questions remain about the evasion/avoidance/aggressive tax planning debate. ACCA has always been clear - tax evasion is a criminal activity and ACCA believes companies should not, in principle, pursue aggressive tax avoidance. Multinationals need to be clear about the value they bring for the benefit of their shareholders and wider society, and to communicate to all stakeholders their underlying commitment to the building of a sustainable business. Companies must see the management of tax obligations as part of that process of creating long-term value.'
Sinclair Davidson concludes: 'My report ends by saying that multinational corporations add value to both their home economies and their host economies. Tax havens add value by allowing multinationals to reduce their tax liabilities while increasing their investments in high-tax economies. An increase in their tax burdens would reduce those levels of investment, leading to reduced employment opportunities, reduced consumption and reduced innovation.
'It is not clear that tampering with the tried and tested norms of corporate income tax to possibly generate more corporate income tax revenue while reducing the corporate income tax collected in foreign economies, and possibly reducing investment, employment and consumption at home, is good policy.'


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Levolor Perceptions Soft Vertical ShadesON SALE
Average Rating:
Change Sizes to Update Price
$318.01 - $381.75
$424.01 -
$509.00 (
Off )
Fall Savings! Extra 20% with coupon code: FALL-20. Sale ends October 17.
Free Shipping & Delivery: Typically made in 5 Working Days
Available Colors & Samples
Threaded Sheer Collection
Opacity: Sheer
+ Add Free Sample
+ Add Free Sample
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Options & Upgrades
Description & FeaturesLevolor presents a beautiful window covering that functions as a light filtering drapery and a room darkening shade all in one. Perfect for adding ambience to formal rooms or casual settings, Levolor Perceptions Room Darkening Sheers are the most versatile window covering for any decor. Choose from a wide variety of fabric, valance, and control options that fit any room. Levolor's Perceptions are designed to coordinate with a variety of other Levolor products, including cellular shades and fabric vertical blinds, for a continuous decor throughout your home.
- Enjoy a variety of colors exclusive to Levolor- now available in elegant vertical sheers!
- Combines the light control of vertical blinds with the elegance of drapery sheers.
- Designed to coordinate beautifully with other Levolor products with matching colors and coordinating fabrics.
- All fabrics are available for purchase by the yard- use these beautiful materials to create matching scarves for all your window treatments! Please contact customer service for pricing and ordering.
- Available in Cordless Wand control for child safety and a clean look, or with Backstacker for a superior view when partially opened (see option detail).
- Backed by our limited lifetime warranty.
Detailed Specifications
The following information insures a proper fit for installation of your new window covering treatments. Mounting requirements below are for standard options. Mounting requirements may vary based on the selected options.
Specifications may vary based on the selected color and upgrades.
The following methods can be safely used to clean your new window covering treatments.
|Inside Mount Minimum Depth
|2 7/8 "
|Outside Mount Flat Surface Height
|2 3/4 "
|Inside Flush Mount Minimum Depth
|3 1/2 "
|Inside Mount Width Deductions
|1/4 "
|BackStacker with Corded Control
|Minimum Width
|13 3/8 "
|Minimum Height
|12 "
|Maximum Width
|144 "
|Maximum Height
|144 "
|Corded Control
|Minimum Width
|13 3/8 "
|Minimum Height
|12 "
|Maximum Width
|144 "
|Maximum Height
|144 "
|Cordless Wand Control
|Minimum Width
|13 3/8 "
|Minimum Height
|12 "
|Maximum Width
|144 "
|Maximum Height
|144 "
|Hand-Held Vacuuming
|Compressed Air
|Bath tub Cleaning/Water Immersion
|Ultrasonic Cleaning
|Injection/Extraction Cleaning
Measure & Installation
Measuring Tips
- All of Blindsaver.com's window fashions are custom fabricated according to the dimensions given on your order.
- Measurements must be exact to ensure a proper fit. For this reason measure to the nearest 1/8".
- Always measure the exact window intended for the blind. Every window in your home is a unique opening and may differ in exact measurements.
- For accurate measurements always use a 3/4" or 1" steel tape measure.
- To eliminate mistakes first measure the width and write it down then measure the height and write it down.
- Do not take any deductions for mounting clearance on inside mounts. Deductions will be taken by the manufacturers at the factory.
- Please read the rest of our measuring guides and download our measuring worksheet. Links can be found below.
Inside Mount Video
Outside Mount Video
Printable Measuring Guides and WorksheetInside Mount + Worksheet
Outside Mount + Worksheet
Worksheet Only
Installation Guides


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Thursday, September 19, 2013
A U.S. Army soldier with Moncks Corner ties was arrested on Monday for allegedly videotaping his wife engaging in sexual acts with a dog, and posting the videos online.
Ruben Chance James Fox, a Fort Bragg soldier, and his wife, Amber Nicole Fox, were arrested Monday, according to the Raeford (NC) Police Department.
They are charged with multiple counts of crimes against nature involving bestiality, disseminating obscene materials and conspiracy.
Amber Fox also is charged with soliciting a crime against nature.
Both Ruben and Amber Fox are 23 years old. According to Raeford police, Ruben Fox was born in Moncks Corner, and grew up in Alabama; Amber Fox is a Conway native.
The couple met while both were enrolled at Trident Technical College, police confirmed. They both graduated from the school in 2011.
The Associated Press contributed to this story.
© 2016 The Berkeley Independent an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


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Real Housewives of Atlanta star Porsha Stewart discovered last month that her husband was filing for divorce on Twitter – and she's still getting over the painfully public news.
"When you're married you definitely feel like you have the ability to communicate with your mate enough for them to come in and say, 'Hey, we're going to get a divorce.' But that didn't happen," Stewart tells PEOPLE. "I found out about [the divorce filing] on Twitter, which was surprising. I'm still in total shock."
Yet Stewart, 31, is trying to stay strong after her split with former NFL star Kordell Stewart, 40, and beginning to rebuild her life with the help of family and friends, including RHOA costars such as NeNe Leakes, who criticized the Stewarts' relationship in a blog on BravoTV.com prior to the split.
"I'm definitely blessed to have a strong support system around me," Porsha says. "NeNe, she's been through a similar situation in her past. She's telling me to take care of me right now, and that's what I'm doing."
Now that news of the split has begun to sink in, Stewart is starting to focus on rebuilding her life, and she's reconnecting to her "very independent" formerly single self.
"I had my own businesses and I gave that up to become 100 percent wife," she says. "At this point I am finding my way back to that Porsha, back to that independent woman who makes decisions on her own. I'm not living through someone else's eyes and I'm looking forward to that."
"I didn't get married to get divorced," she says. "This is not something that I wanted. But at the end of the day I feel there has to be a bigger blessing in this. ... There has to be something great for Porsha in the future."


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FAIRMONT -The Golden Bears are headed to Charleston as regional champions.
The Oak Glen volleyball team defeated Roane County, 25-9, 25-13, 25-9, in the semifinals and Ritchie County, 25-20, 25-10, 25-21, in the finals en route to winning the West Virginia Class AA Region 1 Tournament title Saturday down at East Fairmont High School.
"It is another step in heading to the state tournament," Oak Glen head coach Ethel Riser said. "Hopefully, it is another step on winning a state title. It means we are right on track. We are where we need to be. We are going to be one of the top seeds in the tournament. We will be playing a No. 2 team instead of a No. 1. It means a lot."
Article Photos
The Oak Glen volleyball team poses with their regional championship trophy on Saturday at East Fairmont High School. (Submitted photo)
Oak Glen defeated Ritchie County in the state final last year. The Rebels had defeated the Golden Bears in the Region 1 Final heading into the state tournament.
"Three of our main starters didn't play varsity last year," Riser said. "The girls filled in, and we didn't miss a beat."
With the two wins, the Golden Bears are now 37-6 on the season.
"Overall, we played well," Riser said. "There were a few mistakes, but nothing major. It was a total-team effort. Everyone played as a team. That is what we need to have happen."
Oak Glen will now play in the state tournament beginning Friday morning down at the Charleston Civic Center.
"We are where I thought we would be," Riser said. "I'm sure some of them thought we were going to be here. Most of the girls were in the same place last year except last year we were not regional champions. We were the runner-up to Ritchie County.
"Being the regional champion makes it a little easier. We won't know until probably Monday who play play on Friday."
For the Golden Bears against the Raiders, Sydney Kell collected 12 points, 48 sets and 11 assists, Morgan Poling produced three points, two spikes, 10 kills, three blocks and two digs and Lacee Porter recorded two points, seven spikes, 11 kills and one block.
Also, Vanessa Hissam added six spikes, five kills and one block, Abby Tice tallied 18 points, five aces, one spike and nine digs and Jessica Stivason ended up with four spikes, seven kills and one block.
Next, Jessica Hutton netted two points and three spikes, Kaitlyn Smith contributed four points and six digs and Carissa Williams chipped in with 18 sets and five assists.
Finally, Madison Juszczak finished with three points, one spike and one kill.
Riser said her players were not nervous heading into the regional tournament.
"No, not really," she said. "The first team was of course much easier. The second team, we already played them once, and we beaten them. I would say no, they were not really nervous."
Against the Rebels, Kell tallied five points, 55 sets, five spikes, two kills and one block, Poling picked up eight points, one ace, four spikes, six kills, seven blocks and seven digs and Porter produced five points, 10 spikes, 13 kills, one block and four digs.
Also, Hissam scored four points to go along with 14 spikes and nine kills, Tice collected five points, one ace, five spikes and 13 digs and Stivason netted eight spikes, seven kills and three blocks.
Next, Hutton ended up with three points, one ace and one spike, Smith finished with 14 points and 13 digs and Williams added 45 sets and 10 assists.
Finally, Juszczak delivered two spikes, four kills and three blocks.
"Yes, the girls were very excited," Riser said about winning the regional title. "This is something we have been planning on. We are looking toward next week. We don't know what the schedule is going to be yet."
The Golden Bears are led on and off the court by their four seniors - Tice, Kell, Smith and Porter.
"The seniors definitely lead," Riser said. "They keep everyone in line. They get everyone enthused when they need to be enthused. They keep everyone calm when they need to keep calm. They are the leaders on and off the court. They take control. They lead by example. That is what they have to do."
Prior to last year, Oak Glen previously won state titles in Class AA-A back in 1997 and 1998 as well the Class AA title in 2008.
The tournament pairings will be determined by a blind draw today.
"We should know Monday morning who we are going to play," Riser said. "They are going to be doing the draw tomorrow night, but we probably won't hear who we play until Monday morning."


text:
Standardized Self-Affirmed GRAS Aloe vera
- Certified by the International Aloe Science Council (IASC)
- ACTIValoe standardized to contain no less than 10% polysaccharide (by dry weight)
- Leading Supplier of the Best Aloe vera in the World
Standardized Self-Affirmed GRAS Aloe vera
April 23, 2010: Aloe vera grower/supplier Aloecorp has announced self-affirmed GRAS (generally recognized as safe) status for its Qmatrix Aloe vera. Aloecorp is the first company to get self affirmed GRAS status in the aloe ingredient industry. Click here to see more information.


text:
WF Celebration Ballpoint
(based on 5 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Reviewed by 5 customers
Displaying reviews 1-5
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outstanding Product!
By DenverB
from San Deigo
Comments about Waterford Celebration Ballpoint:
Love my new pin. It arrived in a beautiful case to include a label for engraving. The fit and finish is outstanding. I like most is the balance in my hand. the crystal just add an extra classy touch...No regrets...i would recommend for use
Bottom Line Yes, I would recommend this to a friend
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Graduation Gift
By Nopz
from Undisclosed
We purchased this gift for a college graduate. The packaging was solid. The pen is better than expected as I am an avid Mont Blanc user so my expectations were high. The polished wooden case with glass view the pen came in was a nice addition for showcasing and the engraving was the final touch. Highly recommend the pen especially if you like a heavier pen with a classic look.
Professional Gift
By JMJS
from Chicago, IL
The highest honor in our company is the Crystal. This pen is a great way to incorporate into our company while being very useful for the recipients. The pen has a great weight to it and is just stunning for both men and women. We are proud to give as a personalized gift and it has always been well received!
First Pen Choice for an Executive!
By ExecWife
from New York
I recently purchased the Waterford Celebration Ballpount Pen for my executive husband for Christmas. This was the first purchase of a "nice" pen. When the pen arrived, we pleasantly surprised at the detail! We had high expectations for the pen but we did not expect it to arrive in such an elegant case with a silver engraving plate. So beautiful! Now for the function of the pen.....awesome!! We both tried the pen out (fine point) and were thrilled! We are both hooked! Now I need a pen of my own! Thank you!!
By guardianmax
from North Reading, Massachusetts
I am excited with my new Waterford Celebration Ballpoint pen. I love the way it feels in my hand and the way it writes; so smooth. I am glad I finally got it.
© Copyright Levenger Company
2016. All Rights Reserved.


text:
(based on 4 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Reviewed by 4 customers
Displaying reviews 1-4
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Fix the paper please!
By Neoretro88
from Undisclosed
I have read several reviews complaining about the paper for the Swiftnotes note pad and I agree. It doesn't tear properly. Will this ever be fixed?
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Great pad, need more it fits
By Mickey
This is a great pad. I ordered several because they are so hard to find. Then I lost my leather jotter. Levenger doesn't have much that these pads fit into so I have to order a new jotter from someone else.
Great Writing Surface
By JonnyC
from NY, NY
Heavy weight paper and smooth writing surface.
By Bells
from Virginia
Good quality paper. The only size that fits my pocket notebook, so I willingly pay the bit higher price to continue to use the notebook.
© Copyright Levenger Company
2016. All Rights Reserved.


text:
Eldorado Small Crossbody Bag - Very Berry
Item# AC2304
Detailshttp://www.kipling-usa.com/eldorado-small-crossbody-bag/AC2304.html Eldorado Small Crossbody Bag Very Berry
Item# AC2304
Select a Color
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The iconic crossbody bag of Kipling complete with an organized interior for a versatile design that's perfect for that person on the go! Dimensions: 6" x 8" x 1"in.Read More
- Adjustable shoulder strap that allows you to wear as shoulder or cross body bag
- Main flap compartment has 1 open pocket, 1 Velcro® pocket and 3 card slots
- Additional flap front pocket with Velcro® closure
- 2 external zippered pockets (one in front/one in back)
- Small furry Kipling monkey keyhanger
- Fabric: Water Resistant 420 Denier Nylon
- Imported
Ground Shipping Delivery: $8*
5-7 business days (if ordered by 12pm EST)
2nd Day Air Delivery: $20*
2 business days (if ordered by 12pm EST)
Overnight Delivery: $25*
1 business day
Shipping to Alaska, Hawaii or Military APO/FPO?
Click here for details
Shipping Internationally?
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*Rates and delivery times for the 48 continuous United States
Returns must be made within 90 days of delivery for a refund of the purchase price, minus the shipping, handling, gift box fee and other additional charges.


text:
Top Definition
a cock that is 15"long,5" around, and ... well always floppy
tim got slaped in the face by ryans floppy donkey dick.
av pimp master ryan 15. mars 2003
Trending Now
Can you define these popular missing words?
A dick that is so big, it dips into the water at the bottom of the toilet bowl!
"Dude I just pinched a loaf in that toilet"
av Spanky Lou 17. juni 2003


text:
offline browser
:D I have a offline browser. But I dont know what is it? How to use it? Do u know any one?
Re: offline browser
Many modern web browsers have a mode entitled offline browsing, where links to webpages are redirected to local copies in a temporary folder. The local copies are generally created automatically in the browser's cache and deleted automatically. Many web browsers allow the user to explicitly set specific pages to be browsed offline, which guarantees that they will not be deleted from the user's cache.
What is the name of the Offline Browser you have??
Re: offline browser
Thanks for your answer. I forgot the name. I dont have it now with me.
|All times are GMT +5.5. The time now is 12:21.


text:
on February 12, 2013 - 8:37 PM
A Mexican national was sentenced to three years in prison following his conviction for unlawfully transporting undocumented workers within the United States, U.S. Attorney William J. Hochul Jr. reported Tuesday.
Santos Hernandez-Perez, 36, was in a vehicle with five undocumented workers from Mexico when they were stopped Feb. 10, 2012 for traffic violations by Niagara County sheriff's deputies.
Hernandez-Perez was driving the men from Tucson, Ariz. to Barker, where two were to work on a farm. The others were destined for North Carolina, according to Special Assistant U.S. Attorney Fauzia K. Mattingly. None had permission to be in the country.
Hernandez-Perez's sentence handed down by U.S. District Court Judge Richard J. Arcara was above the recommended federal guidelines for the crime.


text:
The honors continue to come in for Penn State football coach Bill O'Brien.
O'Brien, who last week was named Big Ten coach of the year by both the media and conference coaches, on Monday was announced as one of nine finalists for the Eddie Robinson Coach of the Year Award.
The award is selected through a vote of the Football Writers Association of America and will be announced Dec. 13. The other finalists are Notre Dame's Brian Kelly, Ohio State's Urban Meyer, Kansas State's Bill Snyder, Stanford's David Shaw, Florida's Will Muschamp, Texas A&M's Kevin Sumlin, Utah State's Gary Andersen and Northern Illinois' Dave Doeren.
O'Brien also is a finalist for the Bear Bryant National Coach of the Year Award after guiding the Nittany Lions to an 8-4 finish in his first year at Penn State in spite of the NCAA's strong sanctions following the Jerry Sandusky child sex abuse scandal and the release of the Freeh Report. Penn State won eight of its last 10 games, closing the season with an overtime victory against eventual Big Ten champion Wisconsin.
O'Brien's predecessor, Joe Paterno, was a three-time winner of the FWAA award (1978, 1982 and 1986).
O'Brien wasn't the only Nittany Lion to get some good news on the awards front Monday. In addition, it was announced that senior Matt Stankiewitch was a finalist for the Rimington Trophy for the best center in the country.
"It's a great honor to be a finalist for the Rimington Trophy," Stankiewitchsaid. "It's a great testament to the guys who play next me, particularly John Urschel, since we have a lot of combination blocking. I thought our offensive line had a very good year under Coach [Mac] McWhorter."
A first-team all-conference pick according to the coaches, Stankiewitch anchored a line that helped the Lions lead the Big Ten in total offense in conference games. The senior from Blue Mountain High School started 27 games in his career.
Stankiewitch is trying to become the Lions' first Rimington Trophy winner since current Indianapolis Colt A.Q. Shipley in 2008. The winner will be announced on ESPN on Thursday.
Louisville's Mario Benavides, Notre Dame's Braxston Cave, Clemon's Dalton Freeman, Southern Cal's Khaled Holmes and Alabam's Barrett Jones round out the finalists.


text:
Man of little or no skill at cs; a newbie
por Anonymous 11 de Março de 2003
Trending Now
Can you define these popular missing words?
Top Definition
1. Prefix for "Everything"
2. A word used by most corporations hellbent on getting rich.
2. A word used by most corporations hellbent on getting rich.
Omnitech, Omnipave, Omnicastrate
por Tots 09 de Novembro de 2003
3. A small car made by Chrysler labeled under it's Dodge brand from the late '70s to early '90s. While often mocked in it's day, it proved to be a decent source for reliable transportation as evidenced by the amount still seen on the road in the US. The Plymouth version was known as the Horizon.
Hey, what year is your Omni?
por anonymous submitter #508 21 de Maio de 2005
What a vegan or vegetarian calls people who eat "normally" or a variety of all types of foods. Where vegetarians don't eat anything that is dead and vegans don't eat anything that came from something from a thing with a pulse.
My omni friends think I am crazy but this is a lifestyle that I love.
My family is omni, excluding myself.
My family is omni, excluding myself.
por eLGrL 06 de Janeiro de 2010
A compass or navigational indicator characterized by giving every direction (Omnious) except the right one. A true OMNI navigator gives a direction exactly opposite to the correct direction.
Oscar: My OMNI compass said to go that way in order to get to Canada, but i stopped in Mexico
por X91 06 de Fevereiro de 2010
A world of warcraft player that clicks 70% of his abilities, but he's actually good at it because he's been doing it for so long.
" You're playing without good keybindings? such an omni "
por Ninefive 02 de Junho de 2016
One of the two main factions in the MMORPG game 'Anarchy Online'. Viewed as the oppressors within the game, they fight against the 'Clan' faction for control of the planet Rubi-ka.
You Omni scum will never rule us!
Omni Tek is your friend.
Oh no! The city of Borealis just went Omni...
Omni Tek is your friend.
Oh no! The city of Borealis just went Omni...
por Tony Masons 31 de Maio de 2006
basically means, ya i know or "i know all that"
coming from the root wod omnipotent. its slang like southern california shyyaaa
coming from the root wod omnipotent. its slang like southern california shyyaaa
dude 1-sick car bro
dude 2-omni
dude 2-omni
por sir micheal of the rocks 16 de Junho de 2009


text:
Top Definition
Place your nuts in a bowl of warm water. Then have a girl put a straw into the bowl and blow bubbles under your balls. Rubber ducky is optional of course.
de irgge5 31 Iulie 2003
Trending Now
Can you define these popular missing words?
When a male or something with nuts submerges their testicles into a cup of warm water while their partner blows profusely through a straw that has been inserted into the cup creating a jacuzzi affect. For added pleasure the penis is usually wildly jerked with the blowers free hand until ejaculation.
The gentle bubbles of the ballcuzzi tickled my sack as I unloaded my penis gravy
de cottonwood 30 August 2006
When a man teabags a warm glass of milk while two women blow bubbles into the milk through straws.
Those two hotties give the best ballcuzzi EVER!!
de Diggler 19 Septembrie 2003
It when a male puts his testicles into a warm bowl of water while his female partner takes a straw and begins to blow bubbles under is testicles while giving him a hand job.
I was getting the best ball cuzzi ever last night!
de ADEGOUGH 08 August 2008
When one takes a bowl (ceramic/glass/plastic) fills it with warm water, preferably around 95°. Lower your testicles into the bowl. Then use a straw (preferably a silly straw) and have someone blow at a steady pace forming small bubbles that massage your scrotum/testicles. Just like a jacuzzi, hence the BALLCUZI
Yo bitch, why dont you grab a silly straw and give me a ballcuzzi, Fuck.
de Tronixx 17 Martie 2007
When you dip your nuts in a cup of warm water, and somebody else sticks a straw underneath and blows.
(Courtesy of Bixi Zeng)
(Courtesy of Bixi Zeng)
The Sheraton Four Seasons in Rome came with a complimentary Ballcuzzi.
de Zaiyan Ahmad 30 Noiembrie 2004
When a girl puts alkasalser in her mouth with water, and a dude puts his nads in her mouth.
This ball cuzzis feels good.
de tourettes1992 23 August 2006


text:
Accessories Needed
Parts List
Easy RC: Engines
Browse O.S.
1-piece crankcase
Crankshaft is set in one long bronze Oilite bushing (no bearings)
Schnuerle porting (AKA Schnuerle scavenging)
Side exhaust
Nylon backplate with remote needle valve
40D carburetor
Aluminum piston with Nickel-plated brass cylinder liner.
One expansion-style muffler #E-3030
One instruction manual and sticker sheet
One assembled engine with glow plug
Two 3x30mm phillips head screws to bolt muffler to engine
Construction: Aluminum 1-piece crankcase, piston, cylinder head
Bore: 23.0mm (0.906")
Stroke: 18.4mm (.724")
Horsepower: 1.2 PS, 1.18 HP at 15,000 RPM
Distance from remote needle to end of crankshaft: 4.5" (114mm)
Distance from center of engine to drive hub: 2.0" (51.2mm)
Distance from center of engine to end of crankshaft: 3.0" (76.3mm)
Height from crankcase bottom to top of cylinder head: 3.3" (84.7mm)
Height/crankshaft center to top of cylinder head: 2.7" (69mm)
Width including mounting ears: 1.9" (48mm)
Width not including mounting ears: 1.2" (32mm)
Width between mounting holes same side: 0.69" (17.5mm)
Width between mounting holes opposite side: 1.6" (40.5mm)
Width between muffler mounting holes: 1.4" (36mm)
Width of exhaust opening: 1.1" (29mm)
Height of exhaust opening: 0.3" (7mm)
Diameter of muffler body: 1.3" (33.5mm)
Angle of muffler in relation to engine: 4�
Weight: 272g (9.6oz without muffler)
Crankshaft Thread Size: 1/4-28
Recommended Props: Break In: 11x6
Trainer and Sport Models: 11x6, 11x7
Scale Models: 12x5, 12x6
Practical RPM Range: 2,000 - 16,000 RPM (This engine will not turn
this many RPM on the ground) RPM curve is when the engine unloads.
Fuel with 5% - 15% Nitromethane and 18% (minimum) oil content
(Most of the 5%-15% fuels we carry meet these requirements)
The factory setting of the needle valves are as follows:
High speed needle: Turn all the way in and back out 2 turns.
Air Bleed screw: Turn all the way in and back out 2 turns.
The coverplate for the FX Series will NOT work on this engine.
jxs 04/14/04


text:
Belton sits while Zwinak shines
WEST LAFAYETTE, Ind. - Bill Belton wasn't injured, which is what many people thought since he only played one play, but instead had a bad week of practice and opened the door for Zach Zwinak to get an opportunity.
Zwinak took full advantage of that opportunity, gaining a career-high 134 yards on 21 carries and anchoring a Penn State rushing attack that ran for 185 yards.
"We all come out every week and try to practice as hard as we can," Zwinak said.
That apparently didn't include Belton last week.
"You've got to earn it on the practice field," coach Bill O'Brien said when asked why Belton, who took the field for one snap in the second quarter, didn't play more.
Zwinak had his third 100-yard game of the season and did the bulk of the running, while Michael Zordich carried 11 times for 33 yards and two touchdowns.
The Zwinak-Belton situation shows the starters that if they don't perform in practice, they can lose their jobs, and shows the backups that their hard work will be rewarded.
"It's not just about our own playing time, too," Zwinak said of practicing hard. "If you come out and have a good week of practice, the line's having a good week, quarterback's having a good week, defense, as a team if everyone comes out each week and practices hard, we're going to execute better."
O'Brien was asked if Belton needs to pass protect better and said that wasn't a factor in his decision.
Moseby-Felder enjoys big game
Brandon Moseby-Felder missed the spring, summer and early training camp with a hamstring injury, so O'Brien said he didn't really know what he had in the receiver. Now he does.
Moseby-Felder caught six passes for 129 yards and the first touchdown of his career. He hauled in a 42-yard catch down the Purdue 6 to set up a TD in the first quarter, then later had a 41-yard scoring grab in the third to make it 34-3.
"The coaches believed in me, and I just wanted to go out there and show them what I can do," said Moseby-Felder, who added, "It feels great to finally get my first touchdown."
Most people doubted PSU's receiving corps after Justin Brown transferred to Oklahoma, but Allen Robinson, tight end Kyle Carter and Moseby-Felder have quieted the critics.
"With Justin Brown leaving, he's definitely probably like the biggest receiver we had, the biggest part of the offense leaving," Moseby-Felder said. "But with him leaving, it opened up doors for me, Allen, Kyle Carter [and others] ... to step up and make plays."
Robinson has 57 catches - just six shy of the school record - and Moseby-Felder said he and Robinson have a "very, very, very [good] competition" going against each other.
"We talk about it all the time, who's going to have a bigger game, who's going to have more catches, and that kind of like motivates us to go out there and do our best," Moseby-Felder said.
Concussion for Dukes
Curtis Dukes suffered a concussion on the first play of the game playing defense on the kickoff team.
"That was a dangerous hit. I was concerned," O'Brien said.
Bench taken off bench
The Lions had the game well in hand late in the third quarter, but O'Brien still decided not to give backup quarterback Steven Bench significant playing time then. Bench did get in the game, however, on the Lions' final offensive series and threw one incomplete pass. His only other playing time this season had been a few plays at Virginia.
There had been speculation O'Brien might try to find a loophole and redshirt Bench despite him already having played, but the coach said that wasn't the case.
TE Carter doesn't make trip
Kyle Carter was listed as probable after suffering an ankle injury late in last week's game against Ohio State, but that appeared to have been a guise by Penn State since Carter wasn't healthy enough to make the trip.
Carter has 35 catches, just six shy of the school record of 41 set by Andrew Quarless in 2009.
"I think he was pretty close [to being able to play]," O'Brien said of Carter.
Ficken enjoys memorable day
It was a happy homecoming for Penn State's kicking game.
Of the Nittany Lions' 70-member travel squad, two - place-kicker Sam Ficken and punter Alex Butterworth - are Indiana natives. Both families hosted large tailgate parties outside Ross-Ade Stadium.
Ficken said he used 27 tickets, borrowing some from his teammates' allotment, and estimated his family's tailgate at "around 80." He made the hometown faithful happy by kicking a pair of field goals, from 27 and 24 yards, along with four extra points and effective kickoffs.
After a slow start to the season, Ficken has now made five of his last six field-goal attempts. He's now 7-of-14 after a 2-for-6 start.
"It felt good," he said of his first game with two field goals. "And having family members in the stadium and my brother and friends here, it felt good to finally have a complete game. Obviously I'm in groove, and I'm staying confident and building on that."
Butterworth averaged 34.2 yards on four punts with a long of 40. But none of his punts were returned, and Lion coach Bill O'Brien praised him "for having one of his better games."
Sideline antics
Late in the game, there was a scrum in front of the Penn State bench. After Purdue linebacker Antwon Higgs was called for a late hit out of bounds, Lion quarterbacks coach Charlie Fisher was noticeably upset and all but had to be restrained.
O'Brien smirked afterward, "I just hope we got that on film," and added that he might designate Fisher as the assistant coach selected to meet with the media this week.
Speaking of animated assistant coaches, strength coach Craig Fitzgerald, despite 38-degree temperature, wore shorts and a T-shirt on the sidelines. Fitzgerald also fired the team up during the pregame warmups by tearing off his shirt during his customary motivational moment.
"It was pretty chilly out there ... [but] nothing is unexpected with him, which is what I love about him," linebacker Michael Mauti said. "He's one of the best strength coaches in the country, in my opinion."
Purdue's season continues to unravel
The Boilermakers had high hopes and even thought they could win the Leaders Division this season, with both PSU and Ohio State dealing with NCAA sanctions. Instead, Purdue's season has spiraled out of control with another blowout loss, and the seat under coach Danny Hope heated up even more.
"It's tough to tell their confidence level," Hope said of his team. "I thought we took the field very fired up. We had sideline energy and game energy. We came in thinking we could win this game. ... We just weren't able to execute and play well, and that's been typical of big ballgames lately."
Hope benched starter Caleb TerBush and went to Robert Marve at quarterback. The Boilermakers had plenty of opportunities early to get something going on offense but failed to cash in on their great field position.
Marve finished 22-of-39 for 138 yards, while TerBush came in late and was 10-of-20 for 155 yards and one TD. Rob Henry also threw two passes, so Purdue aired it out 62 times. The Boilermakers had only 87 yards rushing.
Even the Purdue folks struggle with the Big Ten division names. At one point, the standings were listed on the video board and had the Boilermakers in the Legends Division.
The Boilermakers missed a 37-yard field goal late in the first half as Paul Griggs' attempt bounced off the right upright.
News and notes
Alex Kenney and Jesse Della Valle handled kickoff return duties for PSU. Belton had been a return man. ... Former PSU WR Justin Brown had a big day for Oklahoma with seven catches for 107 yards and one TD in a win over Iowa State. ... Former PSU QB Kevin Newsome got in the game in mopup duty in Temple's 45-17 loss to Louisville. Newsome didn't attempt a pass but had a 42-yard run and carried three times for 52 yards.


text:
Don't pick an unusual name for Baby Cambridge. That's father-of-four David Beckham's advice.
Beckham, 38, who named his eldest child Brooklyn, reckons the royal baby should be named David, if it's a boy.
Asked for his baby-name thoughts, the soccer star told Sky News, "David's not bad. I think they should go for David," he said with a laugh.
But whatever the gender or the name of the future prince or princess, Beckham has no doubt that Prince William and Kate are "going to be amazing parents, because they are so loving towards children."
He adds, "William's been in all of our lives for so many years. We've seen William grow from that young boy into an unbelievable gentleman. That's an amazing quality. And that as a father is so important."
He added that he hopes one of his sporty sons – Brooklyn, Romeo or Cruz – follows in his footsteps.
"I'd love one of them to be a football player. It might end up being [daughter] Harper – she might go into it. If one of the boys go on to play football, then great," he says. "I want them to be healthy and I want them to be fit."
And they aren't the only ones keeping fit. "[Victoria]'s up at 6:30 every the morning, running. She's very fit. Harper sits there and watches her."
David Beckham Picks Royal Baby Name: David, If It's a Boy
Pacific Coast News; Splash News Online


text:
Now the company can celebrate an important
milestone -- its first
profit. After many months in the red, July saw the company
in the black, making $1M USD in profit on $20M USD in revenue.
The profits came thanks to a record 109 cars shipped in the month.
Manufacturing cost cuts also helped to enable the profit.
Chief Executive Elon Musk comments, "There is strong demand for
a car that is unique in offering high performance with a clean
conscience. Customers know that in buying the Roadster they are
helping fund development of our mass market electric cars."
like many R&D driven greentech firms, offered a target date for
profitability. However, it appears that Tesla is one of the few
to actually deliver on such a date -- having projected
a profit in "mid-2009".
The Tesla Roadster
undeniably features the most attractive production electric vehicle
body design to date. They also offer fittingly sporty
performance and a utilitarian 244-mile range. In other words,
while expensive, the Roadsters do deliver a strong experience.
Currently, the Roadsters retail for a base price of $109,000.
has borrowed
$465M USD from the U.S. Department of Energy, to produce a luxury
sedan reachable by more customers at a price point of $49,900.
This new model will be called the Model
The company is also working with Daimler to create
electric versions of the popular Smart car. Late this year, the
company will deploy a fleet of the 1,000 of the electrified
ultra-compact vehicles. Tesla is also set to deploy a
higher-performance version of the Roadster -- the Roadster Sport --
in 2011.
quote: $20M revenue; 109 cars sold = $183k per car. Something doesn't add up.
quote: 109 cars were shipped. The article doesn't say how many cars were actually sold.
quote: Its nice to see new and fresh ideas and innovation coming to the car market.


text:
A Manchester man is facing charges after police said he pulled out a gun during an argument over a parking space.
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text:
Top Definition
A donkosorous is an Individual who is UNBELIEVABLY stupid! Donkosorous is not even enough to explain this EXTREMELY stupid individual. Who ever knows a Donkosorous I feel so bad for you.
Eric is such a donkosorous!! SOOO irritating!
Albert is such a Donkorous!!!
Albert is such a Donkorous!!!
Beküldő: Laalatreala 2010. április 4.
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Can you define these popular missing words?


text:
Top Definition
a slang term to describe the state of being high or "drugged up" to the point where one is incapable of basic thoughts and functions. Sometimes used between staff members in hospitals
- How's the guy in room 1209 doing?
- Man, he's fuckin' gorked!
- Man, he's fuckin' gorked!
от MrPinkPickles 11 ноември 2007
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Can you define these popular missing words?
being high, or coming down from a high. being totally baked, stoned, lit, ect.
Dude, Kevin was totally gorked at school!
от NaLo 18 април 2008
An excuse said when you dont really have the patience or any care of what the person or group is trying to talk to you about! A state of insomnia and paranoia and anxiety mixed with a short fuse and not a care in the world about your decision or mood!
I look like crap? What did you expect im gorked? I just ran a red light who cares Im gorked! my eyes look funny because im gorked!
от a retired gorky 11 февруари 2010


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The relatively flat landscape of Seneca County was a surprise to Capts. P.B. and Becky Stetser, the new pastors of Tiffin Salvation Army. They have spent the past four years at a corps in Buffalo, N.Y.
"Most of our married life, we've lived in upstate New York," P.B. said. "I think what we miss most about New York is the mountains."
Becky is originally from Baldwinsville, N.Y., near Syracuse, while P.B. grew up in "south Jersey, outside of Philly." Walking to school past battlefields, he developed a natural interest in American history.
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"This is the first time we have lived outside the 13 original colonies," he said.
Before joining The Salvation Army, P.B. worked as a Methodist minister with Youth For Christ. He graduated from United Wesleyan College in 1976 and was ordained in 1981.
While in college, he met Becky LaQuay, whom he married Nov. 29, 1975. P.B. said he has worked in a variety of ministries, such as youth minister/missionary, executive director, urban ministry director and "Wraparound" (one-on-one supervision of at-risk youth).
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Vacation Bible school is planned for the evenings of Aug. 8-12. The theme for the event is "Pandamania."
For more information about either event, call (419) 447-2252.
"My wife worked most of our marriage, too. She was a floral designer. She has training in horticulture and landscaping and also did beautiful silk flowers. She did dozens and dozens of weddings for people," P.B. said. "We've both had the benefit of a lot of experience in a lot of different things in other places where we've been."
Becky also worked as director of a children's day care facility for a time. P.B.'s other jobs included professional photographer, self defense instructor, EMT and adult educator at a local cooperative extension office. At one point, Becky was doing two jobs and P.B. worked three.
In addition, their family has kept them busy. It includes two adult daughters, Jesi and Heather, who live and work in Elmira, N.Y., and an adopted son, Ben Stetser of Niagara Falls, N.Y. Jesi has one child and another on the way. The couple also has an extended family who have lived with them various periods of time. Some had no safe place to go.
"You know how some people bring dogs and cats home? I brought kids home. We've had about a dozen kids over the years. Some were through foster care agencies. Some, I just brought home," P.B. said.
One young man even moved with the Stetsers when they received a new assignment. P.B. said "Bubba" was from a good family but seemed to have no direction for his life.
Eventually, he went to college and now has a regular job. They still consider him their son, and he attends their family gatherings. A picture from 2008 is posted online at www.stetserfamily.com.
The Stetsers joined The Salvation Army in 1998. They attended The Salvation Army School for Officer Training, which is equivalent to a seminary. P.B. said he was the second oldest in his graduating class.
"It was definitely a change of career for us. Most of the folks that have been in the Army for years assume that we're majors when they see us," P.B. said. "We're a lot more experienced than we were. When we first began, we were pretty much neophytes."
The Salvation Army is theologically similar to the Methodist church, but the couple likes the Army's service-oriented element. It tries to provide for the physical and social needs of people before addressing their spiritual needs. They served six years in Herkimer, N.Y., and three years as assistant corps officers in Canandaigua, N.Y. before moving on to Buffalo.
The captains said many people do not realize The Salvation Army is actually a church. The Stetsers like the service element that was lacking in their former ministry.
At the first corps they served in Herkimer, N.Y., they did a holiday project to provide a holiday dinner and collect toys for area children. P.B. said he felt blessed to be the "conduit" for the community's generosity.
The couple said they are excited about the opportunities available at their Tiffin assignment. They already have become acquainted with CROSSWAEH residents who come to the corps to help with the soup kitchen, maintenance and organizing donations of food, clothing, personal and household items.
"We have a clothing room that they do twice a month," Becky said.
"Our very efficient receptionist/secretary, Diana, just gave me a report on hundreds of people whose lives were touched this past month by (the corps) helping to pay rent, prescriptions, utilities, food and housing. Some of this went on in between officers. It's exciting to know that we have a great team. ... We're really blessed with a great staff here," P.B. said.
Last Sunday, the Stetsers led their first worship service in Tiffin and met with church members afterward to get acquainted. A guitar player and gospel musician, P.B. plans to use those skills in his ministry in Tiffin. The couple also must oversee the continuing capital campaign to finance phase 2 of the building program. Its goals are to finish the main chapel and to make the exterior "look less like a warehouse."
With her experience in botany, Becky would like to pursue some new gardening projects. While she was on the extension service board, she was involved in a container garden project that may be feasible to do in Tiffin.
"We'd take five-gallon buckets and fill them with a layer of drainage and soil and then planted four different things, peppers, cucumbers, tomatoes and beans. I think they were $5, and people could stop and get them. A lot of senior citizens did it to put on a balcony or back porch," Becky said.
Another family they knew in Buffalo had a vacant lot where they installed raised-bed gardens and allowed people to plant and care for a section. The property in Tiffin has space that could be developed for such a purpose.
"I think that would be a neat opportunity here, to offer raised beds out here in the side yard and say, 'This belongs to you. Plant whatever you want,' and help them learn they can provide for themselves," Becky said. "There's something about growth that excites people, no matter what age."


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The Bureau of Consumer Protection Business Center website contains a data security section with material to help people learn how to secure their information. The website section contains a list of educational documents discussing information security, information about data security related laws, reports, workshops, and more. It also has an interactive tutorial over protecting personal information.


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on May 12, 2013 - 10:37 PM
, updated May 13, 2013 at 12:01 PM
April 22, 1930 – May 11, 2013
Ann Billittier of Hamburg, co-owner of the popular Chef's restaurant at Seneca and Chicago streets and devoted to causes that helped the children and less fortunate of the community, died Saturday in Tidewell Hospice in Sarasota, Fla., after a short illness. She was 83.
A native of Buffalo, the former Ann Battaglia worked beside her husband, Louis J. Billittier, to build Chef's into a family restaurant that became a favorite meeting spot for local political leaders and other notables. Mr. Billittier died in August 2000, and the restaurant now is operated by the couple's children, Mary Beth and Louis John Billittier.
Ann Billittier managed Chef's on her own in the 1950s while her husband served in the Korean War.
In addition to building their business together for decades, the Billittiers were devoted to helping the mentally ill, the physically challenged and the children of the community. Ann Billittier became a founding member of the Louis J. Billittier Foundation, named after her late husband, which supported groups as diverse as Buffalo Hearing and Speech Center, Bornhava, Variety Club of Buffalo, Roswell Park Cancer Institute and others.
In a 1995 article for "Living Prime Time," Mr. Billittier commented that he and his wife "were in grammar school together. I remember putting her pigtails in the inkwell at school. I remember getting into trouble for it, too."
Later, despite the demands of their growing business, Mrs. Billittier continued to honor every Sunday as family day, closing the restaurant and keeping the family together on that day.
In March 2013, Ann Billittier and the Billittier family were honored by the Castiglia family at the annual St. Joseph's Day Italian American dinner. At the dinner, Charles Castiglia, the owner of Lakeside Funeral Home in Hamburg, said that what made Ann Billittier and her family so special is not only the work they did for the community, but also their commitment to family.
She was known as a fixture at charity events, and this past month she joined her daughter Mary Beth in support of her son Lou's chairmanship of the Buffalo Hearing and Speech Center Gala at the Seneca Niagara Event Center. In May 2012, the family joined together to support Bornhava school for children with special needs and was active in the live auction for her granddaughter Jenna. She had also been a member of the Variety Club Women and was active behind the scenes for two decades wearing the familiar red coat as she collected telethon pledges. She also joined the family for the presentation of the Louis J. Billittier Award to help area business leaders, and dinners in support of the Franciscan Center.
During a surprise honor for the Rev. Joe Bayne at a Billittier Foundation golf event the priest said, "Annie is true leader and inspiration."
In February 2011, she and the family gathered to witness the unveiling of "Carvings for a Cause," a statue made in honor of Lou Billittier from trees left from the devastating 2006 October Surprise storm.
Mrs. Billittier was a member of St. Francis of Assisi Catholic Church in Athol Springs.
Survivors include her son and daughter.
Funeral arrangements, being handled by the Lakeside Funeral Home of Hamburg, are incomplete.


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LOYSBURG - Jaws and E.T. were part of the Everett band's halftime show, but there was no Hollywood ending for the Warriors Friday night.
That story belonged to Chestnut Ridge and Trent Lohr.
The sophomore running back, playing in his first game the entire season, had a 51-yard run to set up a touchdown and ran in a key two-point conversion as the Lions won their first playoff game in school history, 22-21, over Everett in the District 5 Class AA championship game at Panther Community Stadium. With the victory, Chestnut Ridge earned a ticket to the state playoffs and will play the District 9 champion in two weeks.
Article Photos
Mirror photo by Gary M. Baranec
Chestnut Ridge's Jacob Mock scores during the second quarter as quarterback Beau Bosch signals a touchdown in Loysburg.
"I tore my meniscus at the beginning of the season, before it even started," Lohr said. "I got surgery the second week of the season and rehabbed it to get back for this game.
"This is the first week I practiced. I didn't get cleared until the end of last week. This is the best feeling ever; we had never won a playoff game and now we're district champions."
Similar to the plot of most sports movies, things didn't start off well for the Lions.
Beau Bosch fumbled the snap on Chestnut Ridge's first offensive play, and Everett recovered. The Warriors marched 54 yards on 11 plays and cashed in with a score when Barkley Rhoat found the end zone on a 6-yard run.
Everett attempted an onside kick and had an excellent opportunity to recover it, but the ball took a strange bounce and went out of bounds. Ridge took advantage of the short field with a four-play drive highlighted by Lohr's 51-yard run and capped off by Bosch's 1-yard sneak.
"It was real exciting to get out there and have an impact," Lohr said. "Not being out there all year, I was only in on a couple plays, but it worked out."
The Warriors struck next, taking advantage of a 6-yard punt by Chestnut Ridge, and drove 27 yards for another touchdown. Everett quarterback Spencer McInroy found Kyle Droz all alone in the end zone for an 11-yard score. The Warriors decided to roll the dice on a fake extra point, and McInroy took a direct snap from the kicker's position and threw to a wide open Jared Donelson to make it 15-7.
It didn't take long for Ridge to respond.
The Lions took advantage of a 15-yard facemask penalty on the kick return and got a 1-yard touchdown run from Jacob Mock. Mock finished the contest with 103 yards on 23 carries.
"[Mock has] done a great job for us all year," Chestnut Ridge coach Max Shoemaker said. "He runs with a lot of energy and desire, and I think he showed that again tonight."
The Lions took their first lead of the game by taking the opening kickoff of the second half for a score. Mock finished the drive with a 5-yard run, but the story of the drive was the penalties Everett made. The Warriors got tagged for taunting on the kick, a personal foul that extended the drive and a facemask.
When Everett got the ball back, it was without McInroy, who not only tossed a touchdown pass but was Everett's leading rusher in the game with 40 yards on nine carries.
"He had a separated shoulder," Everett coach Mark Kirk said. "So we put Droz in. He's played some quarterback this year, but taking Spencer out probably hurt us a little bit."
It certainly didn't hurt on Droz's first throw, which went for a 63-yard score to Kyle Sheaffer. The snap on the extra point was bad, however, and Droz's pass after the botched kick attempt fell incomplete.
The Warriors seemingly recovered an onside kick following the score, but a penalty wiped it out.
"The explanation I was given was that we didn't give them an opportunity to catch the ball," Kirk said. "The kick hit their guy in the head. They said that's not the way it works, but that's the explanation I got. I'm sure they know what they're doing, but it seemed as though it bounced off the kid's head and we recovered it."
Everett got two chances from inside the Chestnut Ridge 30-yard line in the fourth quarter, but the Ridge defense turned the Warriors away.
Everett got the ball back one more time with 2:59 left, and Rhoat was wide open deep on the first play. Droz's pass overshot the speedy running back, and Matt Wiley closed the door on the game with an interception two plays later.
"I was in the right place at the right time," Wiley said. "I never felt a feeling like I did when I caught that ball. This means a lot to our seniors and everyone at our school."
Everett7 8 6 0 - 21
Chestnut Ridge7 8 7 0 - 22
First quarter
E-Rhoat 6 run (Droz kick), 7:01.
CR-Bosch 1 run (VanMeter kick), 5:49.
Second quarter
E-Droz 11 pass from McInroy (Donelson pass from McInroy), 9:21.
CR-Mock 1 run (Lohr run), 5:03.
Third quarter
CR-Mock 5 run (VanMeter kick), 8:14.
E-Sheaffer 63 pass from Droz (pass failed), 7:12.
RUSHING: Everett-McInroy 9-40, Karns 7-25, Rhoat 7-16, Droz 4-8, Sheaffer 2-7, Jays 1-2, Ritchey 1-(-2), TEAM 1-(-1). Chestnut Ridge-Mock 23-103, Bosch 19-42, Lohr 3-64, M. Wiley 5-14, White 1-0, TEAM 3-(-3).
PASSING: Everett-McInroy 2-6-0-18, Droz 1-8-1-63, Jays 0-1-0-0. Chestnut Ridge-Bosch 2-2-0-26.
RECEIVING: Everett-Sheaffer 1-63, Droz 1-11, Karns 1-7. Chestnut Ridge-College 2-26.
INTERCEPTIONS: Everett-none. Chestnut Ridge-M. Wiley.
First downs713
Yards rushing31-9755-218
Passing (cmp.-att.-int.)3-15-12-2-0
Yards passing8126
Total yards244178


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Researchers report on the use of genetically modified stem cells to generate new muscle fibers and improve disease-associated muscle function and phenotype in a mouse model of Duchenne muscular dystrophy (DMD).
The Italian team, headed by scientists at Milan's San Raffaele Scientific Institute, first isolated blood vessel-associated stem cells known as mesoangioblasts from dystrophic mdx mice that lack the mouse dystrophin gene. They corrected the genetic defect in the cells using a human artificial chromosome (HAC) containing the entire human dystrophin gene (DYS-HAC) and then transplanted the DYS-HAC-carrying mesoangioblasts back into the immunosuppressed animals.
They found the transplanted cells proliferated and differentiated into muscle cells and expressed the human dystrophin gene. As a result the recipient animals demonstrated both morphological and functional improvements lasting several months. Giulio Gossu, M.D., Francesco Saverio Tedesco, M.D., and colleagues report their results in Science Translational Medicine in a paper titled "Stem Cell-Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy."
Gene therapy approaches to treating DMD are not straightforward because the dystrophin gene is too large to be carried by viral vectors. As a result, gene-based platforms have centered on mini- or microdystrophin genes, or on exon skipping approaches.
The San Rafaelle's strategy builds on two technologies developed Dr. Gossu et al.'s team. Firstly, the researchers recently reported on the isolation and characterization of blood vessel-associated mesoangioblast stem cells and demonstrated that the cells can differentiate into multiple mesoderm cell types into skeletal muscle.
Importantly, when delivered into the arterial circulation, mesoangioblasts can cross blood vessel walls and take part in skeletal muscle regeneration: Previous research has shown the cells can even help ameliorate signs of muscular dystrophy in a canine model, they claim. In fact, donor (HLA)-matched mesoangioblasts have been expanded under clinical-grade conditions and are currently being transplanted into DMD patients in a Phase I/II trial at the Institution.
The second technology is based on the use of HACs and in particular the researchers' development of an HAC vector containing the entire human dystrophin gene. Initial studies with the DYS-HAC construct has shown that it can correct induced pluripotent stem cells derived from DMD patients.
Dr. Gossu's team has now combined the two platforms to develop the engineered stem cell-based approach to treating DMD. In their first set of in vivo experiments they isolated mesoangioblasts from mdx animals, expanded the cells and modified them using dystrophin-carrying HAC. The HACs were in addition engineered to carry the EGFP tag to facilitate imaging and were transduced with MyoD to help promote their differentiation into skeletal muscle post-transplantation. Transduction with MyoD also eliminates the variability in spontaneous mygenic potency that has been observed among different mesoangioblast populations, the authors note, but doesn't interfere with cell proliferation or migration.
The resulting engineered and dystrophin gene-carrying mesoangioblast cells were then injected intramuscularly into 4-month old SCID/mdx mice. Imaging studies showed that muscles receiving injections of the DYS-HAC-corrected mdx mesoangioblasts extensively engrafted, while RT-PCR analysis of treated mice demonstrated expression of muscle-specific human dystrophin.
Immunohistochemical and Western blot analyses of the transplanted muscle revealed reconstitution of the dystrophin protein complex. Histological and biochemical analysis of muscles receiving mesoangioblast injections demonstrated amelioration of the morphological signs of the dystrophic phenotype, with reduced infiltration of muscle by mononuclear cells and reduced expression of inflammatory factors.
Notably, the authors add, the transplanted muscles of dystrophic mice produced 25% of the amount of dystrophin produced by muscles of healthy control mice, while measurements of the cross-sectional area of skeletal muscles in treated compared with untreated SCID/mdx mice and SCID control mice revealed a partial normalization in the treated dystrophic animals.
The researchers moved on to test DYS-HAC-corrected mdx mesoangioblasts in terms of long-term stability of the DYS-HAC vector and fidelity of dystrophin gene expression in vitro and in vivo. FISH and PCR analyses confirmed both that the HAC vector was not integrated into the host genome and that it contained the correct series of human dystrophin gene regions after more than 30 population doublings in vitro and after eight months in vivo. RT-PCR demonstrated correct tissue-specific expression of the human dystrophin gene.
Because mesoangioblasts have the ability to cross blood vessel walls after intra-arterial delivery, the researchers then injected MyoD-expressing DYS-HAC–corrected mdx mesoangioblasts into the femoral artery of SCID/mdx mice. A few of the cells were detectable in myofibers within 12 hours, and by 36 hours there was clear evidence that the transplanted cells had uniformly dispersed in downstream muscles. Three weeks later clusters of dystrophin- and EGFP-positive fibers were evident, and skeletal muscle-specific dystrophin transcripts and protein were found at about up to 18% of the levels found in control animals.
The treated SCID/mdx mice in addition demonstrated amelioration of histological changes in skeletal muscle. "These results demonstrate the ability of corrected mdx mesoangioblasts to actively participate in muscle regeneration by crossing blood vessel walls after intra-arterial injection," the authors write.
To evaluate whether phenotypic muscle changes were accompanied by functional changes as a result of DYS-HAC-corrected mdx mesoangioblast therapy, the researchers measured motor capacity, myofiber fragility and specific force in both treated and untreated SCID/mdx animals. Encouragingly, both intramuscularly and intra-arterially transplanted mice showed markedly enhanced muscle force, motor capacity and voluntary motor capacity than control SCID/mdx mice, and the beneficial effects remained evident for several months.
Moreover, muscle fibres of treated animals also stained to a far lower degree with Evans blue dye (EBD) - which specifically stains damaged fibers than untreated animals. "EGFP-positive fibers always stained negative with EBD, indicating that dystrophin expression from the DYS-HAC vector prevented membrane fragility and subsequent permeability to this dye," they state.
Finally, and to test therapeutic efficacy in a more severe dystrophic model, the resaerchers transplanted corrected mdx mesoangioblasts into immunosuppressed Sgca-null mice, which develop progressive muscular dystrophy and ongoing muscle necrosis with age. These treated animals similarly demonstrated enhanced motor capacity and reduced uptake of EBD.
The overall results "provide evidence for effective stem cell-mediated gene replacement therapy with a HAC in dystrophic mice," they conclude. "Transplantation of SCID/mdx mice with corrected mdx mesoangioblasts reduced myofiber fragility and increased exercise tolerance by more than 50%. Intramuscular transplantation resulted in about 10% of myofibers becoming dystrophin positive, which resulted in production of dystrophin at 20% of the levels found in wild-type SCID mice, which possibly may reflect increased dystrophin synthesis in donor cell nuclei."
They note that for intra-arterial administration, an injection of 106 cells was enough to constitute a similarly effective dose. Together, the data is consistent with reports indicating that dystrophin production as low as 30% of that found in healthy animals or individuals prevents muscular dystrophy in mice and humans.
While the reported studies were carried out in immunosuppressed mice, immunosuppression in a clinical setting might not required, the team points out, especially if a new generation of DYS-HAC vectors was developed that didn't carry any immunogenic transgenes such as EGFP. Other advantages of the engineered mesoangioblast approach include its potential applicability to all DMD patients irrespective of their dystrophin mutation, the presence of the entire dystrophin gene locus and so correctly regulated expression of the different transcripts and improved safety due to the episomal nature of HACs that don't integrate into host cell chromosomes.
There are some technical as well as regulatory hurdles that will need to be addressed before the approach can be progressed to the clinic, the authors admit. In particular, human mesoangioblasts will require an additional step to extend their proliferative capability and to ensure that they survive selection after HAC transfer. To this end, the team says it is developing a platform for engineering mesoangioblasts from DMD patients that contain excisable lentiviral vectors expressing immortalizing genes.
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