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Quantitative gene-expression studies performed with RT-qPCR require normalization of target genes using reference genes that are stable and independent of variables tested in experiments. However, there is no one reference gene that is universally applicable to every study, says Virginia Rebecca Falkenberg, Ph.D., microbiologist, Centers for Disease Control.
"Although a number of reference genes have been described for a wide variety of tissues and experimental conditions, they are not universally suitable or necessarily even present in all samples. For example, common reference genes are lacking for RNA derived from whole blood as well as isolated peripheral blood mononuclear cells (PBMC). Further, there are no suitable reference genes for analysis of many chronic and neuropsychiatric diseases for which blood may be the only sample to study gene expression as a systemic sensor of multisystem pathology."
Dr. Falkenberg and associates initially were working on large-scale clinical studies for biomarker identification for various diseases. "We had received both PBMC and whole blood from patients that were obtained at the same time points. It is very unusual to have access to both. We set out to identify a suitable common reference gene. We first performed a literature review and analyzed our unpublished microarray datasets. We generated a set of six possible reference genes. We then used two algorithms (geNorm and NormFinder) to find the most stable genes for both PBMC and whole blood RNA."
Next, Dr. Falkenberg changed an additional analysis program in an important and instructive way. "I modified a method called single control normalization error (E). Data is collected for several potential reference genes. To select the best (most stable) genes usually one takes each proposed reference gene and performs statistical analysis comparing one gene at a time to that potential reference gene. I decided to perform analyses by comparing the average of 2–3 genes simultaneously with the proposed reference gene.
"To allow the selection of a reference gene that works in both whole blood and PBMC, I took a single gene or average and the comparison was between the two different tissues instead of two different genes. This greatly improved the process allowing us to identify Phosphoglycerate kinase 1 (PGK1) as one of the optimal normalization genes for both whole blood and PBMC RNA."
The idea of being able to utilize a single reference gene provides a much more cost-effective means for characterizing gene-expression profiles. "Using a single reference gene also improves the ability to compare gene-expression results using blood RNA collected and processed by different methods with the intention of biomarker discovery."
Computation is a crucial step to measure gene expression for RT-qPCR. "Data analysis is not straightforward since it requires many iterative computations for data normalization and optimization," suggests Daijun Ling, Ph.D., scientist, USC Davis School of Gerontology, University of Southern California.
"Oftentimes, PCR machines provide instrumental software that also functions in data analysis. Many just use what the companies provide rather than more suitable software."
Dr. Ling developed an all-in-one computer program based on statistical software called SAS (SAS Institute). "I called this SASqPCR. It provides multiple macros to assess PCR efficiencies, validating reference genes, optimizing data normalizers, normalizing confounding variations across samples, and statistical comparison of target gene expression in parallel samples."
SASqPCR does not require the user be an expert programmer. Rather, the program provides a dynamic interface for user-controllable customization based on specific research aims, data quality, and experimental design. Users can easily test a variety of combinations of different analytical scenarios or even customized analytical processes.
"The advantage of the SASqPCR program for analysis of RT-qPCR data is its versatility. First, SASqPCR has no limitation to the size of the dataset. It also can be used for profiling transcriptomes generated by RT-qPCR, as well as population genetic studies with hundreds of subjects.
"Second, SASqPCR can be easily combined with other SAS procedures for advanced statistical analysis, for example, cluster analysis for transcriptome profiling, or association studies for connecting gene-expression variation with particular biomedical conditions. Users are the final decision-makers in analysis of their data."
Multiple combined datasets or PCR array data can be analyzed. "Users can manage and analyze data in a more traditional way instead of having to rely on proprietary instruments or even plate-based data formats. The final results are basically numeric values that provide a much more straightforward and accurate means to determine how to visualize their results."
Malaria (Plasmodium) continues to remain one of the most devastating infectious diseases on the planet. While new initiatives aim to eradicate the disease, one important aspect of these projects is the necessity for improving diagnosis and surveillance methods. Despite inroads in molecular approaches, the gold standard for malaria diagnosis, epidemiology, and clinical trial efficacy evaluation continues to be microscopy, in particular the Giemsa-stained thick blood smears.
"Microscopy suffers from limitations such as sensitivity, with the average microscopist able to detect about 100 parasites per microliter of blood, but the threshold for fever and clinical disease is less than 10 parasites per microliter for nonimmune patients," says MAJ Edwin Kamau, Ph.D., chief of the department of molecular diagnostics, Malaria Vaccine Branch at Walter Reed Army Institute of Research.
"As we move into an era working to control and eliminate malaria, it is critical that we develop a more sensitive and higher throughput means for detecting smaller amounts of the parasite useful for even subclinical infections. The malaria vaccine and drug development program at the Walter Reed Army Institute of Research is seeking better means of detection, particularly for those subclinically infected. To do this, we sought to develop a highly sensitive genus-specific RT-qPCR assay to detect Plasmodium.
"A number of such assays have been developed that can measure infection more than 1,000 times more sensitively than microscopy or even antigen detection tests. However, one challenge is that most qPCRs target the DNA of the multicopy 18S rRNA genes, which have enough genetic variation to be problematic. It is therefore important that qPCR target amplification of conserved regions of 18S rRNA genes."
Dr. Kamau and colleagues developed a genus-specific reverse transcriptase RT-qPCR assay to detect Plasmodium. "The assay detects both rRNA and DNA and takes advantage of the high copy numbers of rRNA in the genome of the parasite. It can detect 0.002 parasites per microliter of blood, one of the lowest levels detected so far."
According to Dr. Kamau, introduction of the reverse transcriptase step was key. "We were able to improve the assay by approximately 10-fold by adding this step. We verified our hypothesis that RT-qPCR was more reliable than microscopy at lower parasite densities, but not at higher densities. Thus another important finding was that dilution ranges of the sample are important."
Before molecular diagnostic approaches replace microscopy, there are a number of remaining challenges to overcome including the need for stringent standardization of the methodology.
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Those attempting to move on from the Penn State scandal were again reminded last week that the only way to do that is to sequester yourself in Siberia.
And even there, Internet service is available.
If you spent the last week dissecting and discussing the Paterno report, which attempted to discredit the Freeh report, you aren't alone.
The Paterno family, with plenty of money and free time, assembled a decorated team of experts, including former U.S. Attorney General Dick Thornburgh, and released its own findings on the Jerry Sandusky child sexual abuse case.
Jay Paterno used the week to appear on national talk shows, and you have to give him this much: He's a better spokesman than he was a quarterbacks coach. Paterno kept his poise despite being peppered by an ESPN lineup that wasn't buying what the Paternos paid for and are now spreading.
Like the Paterno report, the Freeh report is an opinion. The report by former FBI Director Louis Freeh took on a life of its own when the university accepted it without a challenge and the NCAA used it to issue severe sanctions.
Freeh interviewed hundreds of people and drew strong conclusions. He took some leaps, and from this view, although Freeh turned up some potentially damning emails, I believe none of those targeted knew the graphic nature and the horrific extent of Sandusky's actions.
But did any of them go the extra mile to find out? No.
The Paternos keep saying they are only seeking the full truth - that that's what Joe wanted - and until the trials of Gary Schultz, Tim Curley and Graham Spanier along with Mike McQueary's case versus the university, we'll have to wait a few more months, if not years, for the whole story.
And yet, for someone bent on seeking the truth, Paterno didn't seem anxious to do so when the case was exploding.
According to the recently released book "Paterno" by Joe Posnanski, who spent most of 2011 in State College with access to Paterno and chronicled what turned out to be his last few months, Paterno's family practically had to beg the coach to read the grand jury presentment when it hit during PSU's open date Saturday, Nov. 5, 2011.
Sandusky was arrested, Curley and Schultz faced charges, and Paterno, by his family's admission, was arguing with his son Scott, saying, "Why are you badgering me? I've got Nebraska to worry about."
While virtually every member of the Nittany Nation had combed through and been sickened by the presentment that Saturday, Paterno was finally "convinced," the book said, to read it on Monday.
This might be a case in which the full truth never comes out in part because Paterno is dead and presumably so is Ray Gricar, the Centre County district attorney who declined to prosecute a 1998 allegation against Sandusky.
The 1998 case is pivotal because, although charges weren't brought, it showed that PSU officials, according to the grand jury and Freeh, had a warning about Sandusky well before McQueary saw him "doing something sexual" to a young boy in the Lasch Football Building in February 2001.
The Paterno report does all it can to distance Joe from knowing about 1998. Sue Paterno told Katie Couric she didn't know if Joe knew about 1998. Jay said his father "may or may not have been [the coach]" referenced in the emails.
So it's vague, too. In his last interview 10 days before he died, Joe told The Washington Post he didn't know anything about 1998; he told the grand jury that he was unaware of any rumors or situations involving Sandusky prior to the 2001 incident.
When interviewed by the grand jury in 2011, it's also possible Paterno didn't clearly remember the particulars of either case. Again, according to the book "Paterno," the coach was given last rites in the summer of 2010, when he was seriously and noticeably ill.
Turns out JoePa coached another two seasons after his last rites.
In 2001, though, he was 75 and still with it enough to go with McQueary, rather than send him up the supposed chain of command and outline the urgency - urgency to protect more potential victims and the danger the university, its football program and Paterno himself could face by a passive approach.
Paterno died wishing he had "done more." To his credit, he at least admitted that much - although because he had not been arrested, unlike his colleagues, he could be more free with his words.
There are so many people, intelligent people, with polar opposite views on this case, particularly relative to Paterno and whether he's been unfairly characterized.
He was a giant in life - on the field and off - and that's what makes this case so compelling as it plays out on a national stage and will continue as we brace for another chapter with the trials, perhaps a suit by the Paterno family and a planned book by Jay Paterno.
Unfortunately, it's Penn State's answer to a reality series.
Mirror Managing Editor Neil Rudel can be reached at 946-7527 or firstname.lastname@example.com.

subset: commoncrawl


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Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
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As Immunotherapy Revolutionizes the Cancer Treatment...
Dara BioSciences said today it granted exclusive worldwide rights to develop and commercialize its DB959 to T3D Therapeutics, which will reposition the experimental drug to fight Alzheimer's disease.
Dara said it will receive undisclosed payments that include up-front cash as well as potential revenue tied to development milestones for the renamed T3D-959, which becomes T3D's lead product candidate.
T3D-959 is an oral, highly selective, dual nuclear receptor agonist whose primary target is peroxisome proliferator-activated receptor delta (PPARd). Dara had developed the drug candidate through Phase I clinical trials for diabetes and dyslipidemia.
"This program no longer fits into the strategic focus of Dara as we have shifted our corporate attention to the commercialization of oncology supportive care products," David J. Drutz, M.D., Dara's CEO and CMO, said in a statement.
John Didsbury, Ph.D., T3D's founder and CEO, said in the statement that because of the "highly competitive" diabetes and dyslipidemia markets, his company concluded T3D-959 would be better positioned as a central nervous system (CNS) therapy.
He founded T3D earlier this year, with the goal of developing and commercializing therapeutics for Alzheimer's disease and other CNS disorders. Dr. Didsbury said T3D-959 would fight Alzheimer's by targeting multiple pathologies, including addressing beta amyloid plaque—one of two known hallmarks of the memory-robbing ailment.
"Positive improvements in disease pathologies such as neuro-inflammation, neuronal cell loss, neurotransmitter deficits, tau neurofibrillary tangles, and insulin resistance / lowered cerebral glucose metabolism also are anticipated," Dr. Didsbury added.
While T3D did not disclose the additional pathologies, several drug developers have shown growing interest in new drugs that combat Alzheimer's by fighting the disease's other known hallmark, the accumulation in the brain of tau (or neurofibrillary) protein that blocks the transport of nutrients and essential molecules throughout the cell, leading to neurodegeneration.
As GEN noted earlier this month, the difficulty of combating both tau tangles and beta-amyloid plaque deposits explains why developing Alzheimer's drugs has proven especially difficult, with the five successful treatments all just slowing progression of symptoms for six to 12 months.
Dara expanded from oncology supportive care into oncology treatment following its January 2012 acquisition of Oncogenerix. Through a license from Rosemont Pharmaceuticals, Dara holds exclusive U.S. marketing rights to Soltamox®, an oral liquid formulation of the breast cancer treatment tamoxifen citrate.
Dara also markets Bionect®, a topical treatment for skin irritation and burns associated with radiation therapy; and oral mucositis treatment Gelclair®, for which Dara holds exclusive U.S. commercial rights through a license from Helsinn Group.
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Alanis Morissette Gossip
Alanis Morissette gossip, latest news, photos, and video.
Return of 'Celebrity' Baby Names?
On the weekend, Liv Tyler announced the birth of her baby girl Lula Rose. Once upon a time that might have been offbeat enough to be memorable—like eleven years ago when she named her son the then-unusual Milo. Full Story
Ryan Reynolds's (singing) game
Jim Spellman/ Slaven Vlasic/ Roy Rochlin/ Theo Wargo/ Astrid Stawiarz/ Getty Images
Deadpool opens on Friday. So does Zoolander 2. Promotion has been heavy on both movies. Ryan Reynolds, in particular, has been hustling like we've never seen him hustle. And without being gross about it. He's doing his job and he looks like he's having a great time doing his job. Full Story
Dear Gossips,
So the American Music Awards. And Celine. And Alanis. Both sounded amazing. Definitely two of the highlights. There were some notable presenters too. I enjoy the new, much more congenial Harrison Ford. Like, he was never at Tommy Lee Jones levels of grumpy but this current attitude – playful and light – is definitely refreshing. Read Full Intro
Taylor at Staples: night 3
Christopher Polk/ TAS/ Getty Images
Natalie Maines. Ellen DeGeneres. And Alanis. Alanis! Here's how Taylor Swift introduced her: "She defined the music of her decade. She inspired a generation of confessional female singer-songwriters who all of a sudden felt like you could actually say these raw feelings that you had. Full Story
Dear Gossips,
The JUNO Awards happened last night in Hamilton, ON. We celebrated Canadian music in 2014. And the career of Alanis Morissette, on the 20th anniversary of Jagged Little Pill, who was inducted into the Canadian Music Hall Of Fame and closed the show with a medley that included Uninvited, You Outta Know, and Thank You. Read Full Intro
Family Day for Alanis
It's Family Day today in parts of Canada. Alanis is from Ontario. Ontario observes Family Day. So it all works out then. I'm originally from Ontario too. But now I live in British Columbia. BC does not observe Family Day. F-ck, why not??? Here's Alanis Morissette gloriously happy with her family yesterday in Venice, CA. Full Story
Scarves, green shoes, and wide shoes
Written by Sasha Last May I needed to have a surgery that required that I have my entire thyroid removed as there were growths all over and through it that were potentially cancerous. Ya, it super sucked and now I am left with a scar right across my neck. Full Story
Poo friends?
Thanks to all of you who cared about my poo last week after this article. Turns out a LOT of you are obsessed with poo too. There's even a poo blog. But do NOT google "poo blog" because that one is actually a little too much, even for me. Full Story
Alanis in a groove
These are high times for Alanis Morissette. It's a weak line, but it works. As you know, Alanis is enjoying a 7 ep arc on Weeds (please say you watch Weeds, please say you watch Weeds and not the other bullsh-t) after wrapping a successful 2 year run with Flavours of Entanglement, is supposed to star in a film adapted from Radio Free Albemuth, is happy and healthy, is involved with a non celebrity, and looks better than she ever has. Full Story
Scarjo Mango
She's the new face of Mango. Her friend Penelope Cruz was the old face of Mango. Or maybe she still is a Mango face but they made room for more. In any event, Scarjo has added yet another endorsement to her growing list. She's also currently repping Moet & Chandon (hmmmm... I just got the champagne shakes), D&G cosmetics, and was the face of Louis Vuitton last year. Full Story
Alanis minus 20
Am so not feeling Alanis Morrissette in OK! Magazine gushing about her 20 pound weight loss. Can't put my finger on it but just isn't sitting right. Maybe it's because the styling is for sh-t. Who decided to put her in a long purple dress with those shoes? And those boots with the jeans are all wrong too. Full Story


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my favorite is tsunade off of naruto
yup she's hot and strong....just saying
I have 3
1. Konata from Lucky Star (she is so epic! and no I do not have a little girl fetich -_-)
2. Ren from DearS
3. Death Master from Black Rock Shooter
Anime is life, Creativity is blood
konata from luckystar is my favorite female character she is so funny and entertaining.
so pants off dance off lol :) as i qoute a friend of mine
1. rias glemory form high school dxd
2. all the amagami girls that date tatchibana juichi
3. nagisa from the anime clannad
i love them both
eat my shorts you sapce invaders
1 rias glemory form highschool dxd
2. all the girls from amagami ss
I'm not sure if Yuna from FFX is a anime girl but I'd choose her in the video game series if she was. Yuna IMO if she's a anime girl, she's had several people in FFX to protect her. Rikku from FFX and FFX-2 is possibly likely a anime girl along with Paine who appeared in FFX-2. Overall in the Video game series, I'd prefer Yuna if she is, if not, then I'll go with Paine.
In the TV series, I favor the following: Riza Hawkeye from FMA, The deceased "Lust" from FMA, but my favorite from the TV series primarily the most is "Riza Hawkeye" because of the way she fires her guns and uses two guns very often. She's the best.


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[MP3] EAR CANDY | Lykke Li – "Get Some" (Beck Remix)
I have to say, I'm pretty excited for Lykke Li's sophomore album, Wounded Rhymes (due out March 1 via her own label, LL Recordings).
I loved Youth Novels (2008), but everyone's favourite Swede seems to be growing up a bit with the introduction of some darker, heavier sounds and downright sassy lyrics ("Like a shotgun needs an outcome / I'm your prostitute / You gon' get some") on the first single ("Get Some") off her forthcoming album, so it'll be interesting to hear the finished package.
Just released is Beck's remix of "Get Some" (which you can download for free). Just thought I'd add a little mp3 treat today since I (and probably a lot of you) are super busy with finals and what not. Think of it as a little pick me up.
Also If you haven't already grabbed her new (though not so new anymore considering it was released back in October) single, "Get Some" and b-side "Paris Blue," head HERE to download it for free! You can listen to the two tracks plus a few remixes below.
Break over. Now back to studying!
[MP3]: Lykki Li – "Get Some" (Remix by Beck) (right-click, save as)


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Top Definition
#AssShakingAna is a viral video on the internet. In the video there is a young girl named Ana Cruz shaking her ass (as explained in the title). It got up to 200,000 views when it was on YouTube and now it is on various sites such as Dailymotion, Twitter, and PornHub.
Ex. 1: Dude, did you see that video #AssShakingAna?
Ex. 2: I just fapped to #AssShakingAna.
Ex. 2: I just fapped to #AssShakingAna.
von MasterTroleSojo 6. Oktober 2012
Trending Now
Can you define these popular missing words?


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Popular Diets
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For some, yoga conjures up an image of emaciated and scantily clad bendy people twisted up like Rold Gold pretzels. This can be a big turn off for those of ample form, but thankfully, several pioneers have paved the way for all sizes to feel comfortable joining a yoga class or practicing at home, so they too can gain the health benefits of yoga.
Megan Garcia, founder of MegaYoga is a plus-sized model based in New York City. She took her first yoga class as a college elective credit in 1991 and since then received her yoga teacher certification at the Kripalu center in Lenox, Massachusetts. In 2004, she teamed up with the plus-size clothing line Just My Size to create "Just My Size Yoga with Megan Garcia," a best-selling yoga DVD for plus-sized beginners. In addition to the video, Megan wrote the book MegaYoga published by DK books in 2006.


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Even before the president has taken the official oath of office, a new issue is brewing in the US. There is a movement among citizens in several states to petition the federal government to allow their respective states to break away from the Union.
There are now petitions from people in more than a dozen states asking for relief by secession from US government. At this point it appears that Texas residents are leading the charge. The Texas petition has already garnered more than 70,000 signatures since Nov. 9.
Although Obama won both the electoral vote and the popular vote, there appears to be an apparently vocal minority out there that would rather break away than live another four years under Obama. While some Americans see this new development as serious, others dismiss the movement out of hand. Is this just the ranting of a few disillusioned people or could it be the beginning of something far more serious?
Let us take a critical look at the situation.
The mechanics of revolt are pretty straightforward. First you need discontent among the people. Obviously this will always exist in some form no matter what. However, when discontent begins to grow and spread, this is when the first seeds are planted. Then we need dissent. Once again, this is another element that always exists among citizens. Dissent is constantly in a state of flux. It waxes and wanes but if carefully observed, it can be kept in check simply by governmental policy modifications.
If the dissent phase is allowed to go unchecked, more people will join the cause, and then dissent escalates to disobedience. Disobedience can come in the form of strikes, sit-ins, boycotts and other forms of relatively nonviolent actions. In cases of unjust laws, many people may openly refuse to obey them. At this stage, most governments will begin to take steps to deal with the issue. This is also a very crucial point in the situation and it depends almost solely on what the government response is to the grievance.
If the problem is not addressed satisfactorily, a new phase of dissent and disobedience begins. This round is usually more confrontational with clashes between citizens and authorities. This is the point of critical mass. The next step to revolt would be the catalyst. A catalyst is something that causes or accelerates a reaction. Once the catalyst is reached, this is usually the point of no return.
Finally we have open rebellion and insurrection. This is when a nation's worst fears are realized. Brother against brother, sister against sister; all engaged in the deadly embrace of violent conflict and inevitable bloodshed. It is the deadliest dance of them all. It is the people against the government but in reality the government is also the people. It is our sons and daughters, our husbands and wives; our friends and families; all pitted against one another and divided by the premise of some ethereal ideology.
And as always, there are the innocents who will be caught in the middle. Those whose only desire is to live and die in peace. These are the ones who will suffer greatly. They will be branded as outcasts and "lukewarm" by one side or the other. Therefore, many will be used as pawns in an ever-widening and all-encompassing conflict, consumed by a fury they are apart from, yet a part of.
Conversely, we must also realize that at times revolution may be necessary to clean the slate and reset the clock. Regardless of where we stand in the scheme of it all, there are a few things we should all consider before we plunge headlong into a cause. First and foremost, we should truly know what it is that we fight for. Often the seeds of revolution are planted in seemingly fertile ground. It is only much later that we realize that the fertile ground was only a veneer covering the desolation that lay just beneath its surface.
And just as importantly, remember that today's friend may quickly turn into tomorrow's enemy after the balance of power has switched hands. Finally, let us not forget that the sword of revolt is the sharpest double-edged blade there is. It will slash both friend and foe, even as it is used to vanquish the common enemy. It is an instrument of necessity at times but no hand that touches it will emerge free and unscathed. For there is a terrible price to be exacted for the freedom it apparently bestows. It is a price remitted with the blood of our own people and a dreadful legacy left to be handed down to our posterity.
If you like to write about U.S. politics and Campaign 2012, enter "The American Pundit" competition. Allvoices is awarding four $250 prizes each month between now and November 15. These monthly winners earn eligibility for the $5,000 grand prize, to be awarded in December.


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Actors who make us laugh
POSTED: 07:30 AM PDT Mar 14, 2013 UPDATED: 09:11 AM PDT Jun 15, 2016
With Kevin Hart starring in "Central Intelligence," opening this weekend, take a look at some of the best comedy actors and actresses of all time.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


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AP Biology For Dummies
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This user-friendly and completely reliable guide helps you get the most out of any AP biology class and reviews all of the topics emphasized on the test. It also provides two full-length practice exams, complete with detailed answer explanations and scoring guides. This powerful prep guide helps you practice and perfect all of the skills you need to get your best possible score. And, as a special bonus, you'll also get a handy primer to help you prepare for the test-taking experience. Discover how to:
- Figure out what the questions are actually asking
- Get a firm grip on all exam topics, from molecules and cells to ecology and genetics
- Boost your knowledge of organisms and populations
- Become equally comfortable with large concepts and nitty-gritty details
- Maximize your score on multiple choice questions
- Craft clever responses to free-essay questions
- Identify your strengths and weaknesses
- Use practice tests to adjust you exam-taking strategy
Supplemented with handy lists of test-taking tips, must-know terminology, and more, AP Biology For Dummies helps you make exam day a very good day, indeed.


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This week's top 5 family fun picks in D-FW
The hardest — and most fun — part of the job: this week's top five family picks!
1.Sesame Street Live's Can't Stop Singing at Verizon Theatre in Grand Prairie. It's hard to think of a more irresistible destination for Sesame Street fans than this show featuring their favorite Muppets singing and dancing. Just don't forget to arrive an hour early for the Play Zone where the kids get to sit in Big Bird's nest, twirl in Zoe's dance studio, sit on the stops of 123 Sesame St. and meet some of the costumed characters. And don't forget your camera! Today through Sunday.
2.Jon Scieszka at Dallas Museum of Art's Arts & Letters Live. You can still get free tickets to the simulcast in one of the museum's C3 theaters and meet Jon afterwards and get him to sign one of his Speaceheadz books. Alas, the main event where you can listen to him live is sold out. Make sure to act quickly on tickets for the great kids' authors coming up March 15: Peter H. Reynolds and pop-up book king Robert Sabuda. Saturday for Jon Scieszka.
3.Come Celebrate Read Across America. Who can resist a birthday party, particularly one for Dr. Seuss? The one at Barnes & Noble at Stonebriar Center will feature a guest in costume, a hunt for Bartholemew's hat (as in The 500 Hats of Bartholomew Cubbins), a free carousel ride and a chance to win a Nook HD tablet. Saturday.
4.Audubon Family Festival: Paws on the Prairie. We're excited about the Trinity River Audubon Center's new free Saturday family programming and we LOVE that they are not only welcoming furry family members, but making them the focus of the fun. You'll be able to take your dog to hike the trails, learn how people and dogs can help the environment and enjoy the wildlife together. Don't have a dog? There'll be information about pet adoptions. There's also a lot to be said for having a good time with other people's dogs and going home to kick off your shoes (and not worry about anyone chewing them). Saturday.
5.'Escape from Planet Earth' screenings for kids with special needs. If you have a kid with special needs, then you can relax and enjoy these wonderful, welcoming screenings at all Studio Movie Grill and select AMC Theatres where the lights are turned up, the sound is turned down and kids can talk, dance and sing as desired. Saturday.


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on November 2, 2012 - 8:49 PM
, updated November 3, 2012 at 12:48 PM
A Buffalo man, still in jail on an animal cruelty charge for driving several blocks with his pit bull leashed to the back of his SUV, does not want to lose the dog to the local chapter of the Society for the Prevention of Cruelty to Animals.
Daniel Delaney Jr., 36, has sought an injunction in state court to block his forfeiture of the 2-year-old dog, Gotti, to the SPCA Serving Erie County.
For now, that will keep the SPCA from finding the unlicensed dog a new home.
"Now there's a stay so we will have to wait for the courts to make a determination," said Barbara Carr, executive director of the SPCA.
"The dog is under medical care, and not ready to go anyplace yet," Carr said. "When he is, we'll probably utilize a foster care situation until the court situation is finished."
The organization has cared for Gotti since Oct. 6, when police officers arrested Delaney on a charge of aggravated animal cruelty, a felony.
Delaney told investigating police officers he forgot the dog was leashed to the back of his vehicle parked outside a store where he had gone to make a few purchases. After leaving the store, he drove away in the Hampshire Street neighborhood, authorities said.
The pit bull suffered leg injuries and lost the pads on his paws as a result of the incident.
Delaney has been in the Erie County Holding Center since his arrest, unable to post $25,000 bail.
A lawyer for the SPCA went to the jail a couple of weeks ago to notify Delaney that he had to claim the unlicensed dog within a certain time period or he would forfeit ownership.
Since he cannot post bail, Delaney has been unable to go to the SPCA to claim the dog, said Sarah E. Ryan, his legal aid lawyer.
But Delaney does not want to lose ownership, she said. "He wants to be able to have his due process."
The Legal Aid Bureau is also defending Delaney in the criminal case. His case is expected to be presented to a grand jury.
The civil matter is before State Supreme Court Justice Patrick H. NeMoyer. A date has not been set yet for the judge to hear arguments on Delaney's motion, a law clerk for NeMoyer said Friday.
But Ryan said she expects the case to be called next week.
Delaney will face another hurdle in keeping Gotti when the SPCA asks the judge to have him secure a bond to cover the SPCA's cost of caring for the dog.
"We'll be petitioning the court for a bond for the care of the animal," Carr said. "Instead of the SPCA being responsible, the fellow who has been arrested will be responsible for his medical care."
The projected cost of Gotti's care – since the dog's arrival at the SPCA and for the next month or so – is more than $1,200, Carr said.
"If he doesn't come up with money to post the bond, the judge can then [say] he has relinquished ownership," Carr said.
That raises the question: If Delaney is relying on a public defender for his legal defense, and he does not have enough money to post bail, how will he be able to pay for the dog's medical care and other costs at the SPCA that might run into the thousands of dollars?
"I think he's always said he wants the dog back," Carr said.
However, the SPCA does not want to give the dog back to him, SPCA officials say.
"It would be completely irresponsible for us to return the dog under these circumstances," said Gina Browning, director of public relations for the local SPCA. "The last thing the SPCA is going to do right now is return a dog to a man who is facing an aggravated animal cruelty charge."
Carr said, "It's always up to the courts to decide."
Ryan, his defense lawyer, would not confirm Delaney wants the dog returned to him.
"At this point, we were just stopping an automatic forfeiture," she said of the civil court action.
Gotti is doing well, Carr said.
"We have great people taking care of him," she said.
email: email@example.com


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Top Definition
When it is snowing so damn much you cant even see a thing.
OMFG, it's a fricken snownami outside!
af Sexa 22. februar 2009
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A tidal wave of heavy, packed snow, plowed onto your driveway by a city snow plow truck, and usually just shortly after you have spent a couple of hours shovelling out your driveway by hand.
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af woiseau 1. april 2008
When snow and wind come together in waves
The weather in Virginia the past few weeks has been brutal Last week we had a snownami.
af LadyDi0003 15. februar 2010


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Local caucus opinions differ over closed-door meetings
March 3, 2013
CHARLESTON — Caucuses are, by definition, private and allowable meetings in government. Some may argue they are integral to the legislative process....
Bobby, your entitled to your opinion, however, those who believe in putting your complete faith in your Government typically means you have a personal invested interest in the individual. Again, thank you for your response. To all others, thank you for your responses and feel free to review my website *******cmillcmanagement.wix****/harrisfordelegate
you can also email me at wmharris2012@gmail****
0 Agrees | 0 Disagrees | Report Abuse »
It is so obvious that the Tea Partiers have nothing better to do than cry and complain and make threats about the next election. You are complaining about a closed caucus meeting where Dems and Republicans can discuss strategy about what is best for the EP. That is their job and that is why they were elected but because you want to complain and pretend that you know better you call people out on the internet. Mr. Harris, Lawrence and Skinner are ten times better suited to serve our area than you could ever hope to be. Just what the Tea Party needs, ignorant people like you and majoritarian who have nothing better to do but spout off at the mouth because they are not smart enough to be involved in the process.
0 Agrees | 1 Disagrees | Report Abuse »
One can't be mad at the closed session. They are just following in Barry's footsteps with a "transparent and open government". WV might not have voted for Barry, but they did elect Democrats to all 3 houses of our state government - WV got what they deserved.
0 Agrees | 2 Disagrees | Report Abuse »
Isn't it precious that Tiffany can be such a friend. Until the next election when the gloves come off and she has her new colleague bully her opponent and the party hacks send out lying attack mail.
Bipartisanship is soooo easy for the Dems, when they know exactly that their Speaker Thompson blocks anything from even being voted on unless it serves their party. Let's put them in the minority and we'll find out how bipartisan they really are.
3 Agrees | 1 Disagrees | Report Abuse »
Yes, I am the one who has been responding to these Legislators over the past few days and this article just lit me up and Skinner refused to respond back to me. I already know the excuse, like Lawrence, "Sorry, I just now got your email." More excuses. We have to remember all this crap on election day.
2 Agrees | 1 Disagrees | Report Abuse »
I'm glad to see Senators Unger and Snyder are unwilling to take part in these secret meetings. Lawrence, Skinner and Espinosa need to be accountable to their constituents. Skinner's arrogance is particularly egregious.
5 Agrees | 0 Disagrees | Report Abuse »
Showing 6 of 6 comments


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- Cheer on your favorite team in this t-shirt by BOSS Green. The logo detail on the front represents the host country and includes the years of prior games in their respective host country color.
- Model is 6'2" with a 32" waist, 40" chest, and is wearing size L.
- Crewneck
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on November 8, 2012 - 5:31 PM
An Ontario woman was sentenced by U.S. District Judge Richard J. Arcara to three years in prison Thursday for smuggling marijuana.
Karlene Powless, 28, of Brantford, Ont., had previously been convicted of conspiracy to import marijuana into the United States from Canada and bail jumping.
Assistant U.S. Attorney Mary Catherine Baumgarten said Powless and co-defendant Danielle Bomberry were arrested at the Peace Bridge in 2004 after smuggling various amounts of marijuana about 15 times before their arrest.
Bomberry, 29, of Oshweken, Ont., was previously sentenced to 3½ years in prison by Arcara.


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MIFFLINTOWN - Roy Allen Schlegel, 53, went home to be with the Lord on Friday, Sept. 21, 2012, at his home, in Mifflintown.
Born Feb. 9, 1959, in Lewistown, he was a son of the late Harold E. and Beulah E. (Sourbeck) Schlegel.
He is survived by: three daughters, Amber K. Imes and husband, Barrett, of Port Royal, Ashley E. Sweigart and husband, Michael, of Honey Grove, and Allison K. Schlegel and companion, James Sheets, of Mexico; brothers and sister, Harold E. Schlegel, of Grovetown, Ga., Ellen D. Hogle, of Lewistown, and Floyd W. Schlegel, of Mifflintown; and five grandchildren, Cameron and Katara Sweigart, Nolan and Myles Imes, and Jackson Sheets.
Article Photos
Roy Allen Schlegel
He was preceded in death by one sister, Debra Ann Schlegel.
Roy graduated from Juniata High School and retired as a foreman for Miller Pipeline. He was a member of the Crawford-Brubaker VFW Post, Mifflintown. He enjoyed going to auctions, watching football, studying his Bible, spending time with his family and playing with his grandchildren.
His memorial service will be at 10:30 a.m. Monday, Sept. 24, at the South Juniata Baptist Church, 3647 Smokey Hollow Road, Honey Grove, with the Rev. Dr. Dennis R. Thompson Jr. officiating.
For those who desire, the family asks that contributions in memory of Roy be made to the American Cancer Society, 324 S Logan Blvd, Burnham, PA 17009.
Guss Funeral Home, Inc., 20 S. Third St., Mifflintown has care of the arrangements and condolences may be left at www.gussfh.com.


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Photos from Saturday at Sunnylands
POSTED: 01:06 PM PDT Jun 08, 2013
Pictures of President Obama and President Xi as they walk the ground at Sunnylands in Rancho Mirage.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


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Summerville resident Dawn Berger made the painful choice this past February to remove both her breasts to avoid developing the same cancer that killed her aunt just months before.
By the numbers
40,775The number of new cases of breast cancer reported in S.C. between 1996 and 2009.68.1The average number of women out of 100,000 who are diagnosed with breast cancer in S.C. each year.40,000The average number of women who die from breast cancer every year in the U.S.2005The year the S.C. Department of Health and Human Services started offering Medicaid coverage to qualifying women diagnosed with breast cancer.11 & 39Black women in S.C. are 11 percent less likely to be diagnosed with breast cancer, but 39 percent more likely to die from the disease than white women.Sources: State agencies
"That's when I decided I'm going to do it," said Berger, 41. "I was tossing the idea around, and when that happened, I was like, OK."
Another test
Two drawbacks of the BRCA1 and BRCA2 genetic test are that it's expensive — $3,700 locally — and these mutated genes account for only a relatively small percentage of breast cancer cases. Also, the absence of these genes doesn't necessarily mean you won't eventually develop breast or ovarian cancer.That's why Iverson Genetics, with labs in Bothell, Wash., and Charleston, is rolling out a $250 genetic test on June 1 that will screen a woman's risk for breast cancer.It will not check for faulty BRCA genes, but rather three genes linked to estrogen metabolism."It's long been known that estrogen metabolites are recognized as a primary risk factor of the development of breast cancer," said Iverson Genetics scientist Christina Mailloux.The test, available through a physician's office, also will weigh other risk factors, including a family history of cancer, the level of hormones a woman has taken over her lifetime and the number of children she has.
Sound familiar?
Aside from the small fact that she's not world famous — she works the night shift as a lab assistant at Summerville Medical Center and freelances for The Post and Courier's Charleston Savvy Shopper blog — Berger's story closely resembles one that Angelina Jolie told in a New York Times op-ed last week.
Genetic testing determined Jolie carried a mutated gene that predisposed her to develop breast and ovarian cancer and elected to undergo a preventive double mastectomy.
"My doctors estimated that I had an 87 percent risk of breast cancer and a 50 percent risk of ovarian cancer, although the risk is different in the case of each woman," Jolie wrote.
When Berger explained her surgery to co-workers — same mutated gene, same family history, same difficult choice — she said she was met with some confusion.
The difference is when Jolie talks about cancer (or picks her kids up from school, cuts her hair or undertakes any number of mundane tasks), people pay attention.
"Her livelihood depends on her being this perfect female," Lucy Spears, mission programs manager at Susan G. Komen Lowcountry, said of Jolie. "I think it can have a very positive effect. We tend to put celebrities on pedestals and forget that they are just as human as we are."
After her double mastectomy, Jolie's cancer risk dropped to 5 percent.
"Our hope is that she has empowered other women to discuss their risk for breast cancer with their doctors — not to scare them, but to encourage them to know their bodies and be their own advocates," said Spears, a breast cancer survivor.
At the Medical University of South Carolina, the genetic test for a mutated BRCA1 (breast cancer 1) or BRCA2 gene, both associated with increased risk of breast and ovarian cancer, costs an average $3,700 and is covered by only some health insurance policies. Also, a mutation of one of those genes is relatively rare. They account for 5 to 10 percent of all breast cancer cases.
Dr. Paul Baron, a breast surgeon at Cancer Specialists of Charleston, added that a patient still can develop breast or ovarian cancer, even if a genetic test shows no sign of a mutated gene.
"That's the most common misconception I hear," Baron said.
MUSC breast surgeon Dr. Megan Baker Ruppel said the genetic test is a powerful tool, but must be accompanied by counseling, which helps interpret the significance of the test results and weigh other risk factors.
"The genetic counseling is the most important part," Baker Ruppel said. "You need to know how to interpret a positive test, but also a negative test."
For example, mutated BRCA1 and BRCA2 genes are linked to breast and ovarian cancer but can indicate elevated risk for other diseases, too, in both men and women, including prostate, colon and skin cancers.
A doctor is trained to help the patient consider these risks and interpret the test results through genetic counseling, Baker Ruppel said.
"There have been a lot of people who have been tested without counseling," she said. "It's being done really inappropriately."
Reach Lauren Sausser at 937-5598 or lsausser@post andcourier.com.


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In the season opener against Saint Francis-Brooklyn, the Miami Hurricanes couldn't make a 3-point shot to save their lives.
On Monday night against the College of Charleston, the Hurricanes couldn't miss.
James Kelly scored a season-high 18 points and Rion Brown added 15 points to lead Miami past College of Charleston, 70-54, before a crowd of 4,018 at TD Arena
The Hurricanes (3-1), who lost their top six players from last year's ACC championship team, missed all 15 3-point attempts they took in their 66-62 overtime loss to Saint Francis. As a team, the Hurricanes were shooting just 28.6 percent from beyond the 3-point arc coming into Monday night's game.
Against the Cougars (1-3), Miami was 7 of 11 from 3-point range, including Kelly's perfect 3 of 3 performance.
"We didn't share the basketball in the first game," said Miami coach Jim Larranaga. "We just took the first shot we could possibly shoot. Tonight, I thought we moved the ball, we shared it, and as a result got some open looks. I think we were a little more patient looking for better shots."
The Hurricanes, who shot 51.6 from the floor for the game, surprised College of Charleston coach Doug Wojcik with their hot shooting.
"They shot the ball better than they have all season," Wojcik said. "At times, especially in the first half, it felt like they were shooting 75 percent. They didn't miss many open looks they got. I thought the combination of their 3-pointers and our missed free throws opened up a gap we couldn't overcome."
The Cougars made just 11 of 22 free throws on the night.
Charleston got off a quick start, scoring on their first three possessions — an Adjehi Baru dunk off the opening tipoff, a 3-pointer from Willis Hall and another layup from the Charlotte native opened up a 7-2 lead just two minutes into the game.
But Larranaga made a subtle defensive adjustment. Instead of trapping the ball screen, he had the Hurricanes defenders switch, no matter who the Cougars had handling the ball. The move proved effective as the Cougars' offense began to slow.
"Charleston ran their offense extremely well," Larranaga said. "We made an immediate adjustment after their first three possessions. We started to switch the ball screen and then used some zone, which we haven't done all season. We just played better and better defense after the first four or five possessions."
With Kelly and Brown knocking down their 3-pointers, the Hurricanes slowly began to open up a lead on the Cougars.
A 3-pointer from Garrius Adams and layups from Manu Lecomte and Donovan Kirk gave the Hurricanes a 29-20 lead with 4:42 to play in the first half.
Miami finished the first half on a 9-3 run to take a 40-25 advantage into the locker room. This despite the fact that Charleston had shot 56.3 percent (9 of 16) from the floor.
Charleston used a 9-4 run to start the second half — Canyon Barry connected on back-to-back baskets and Joe Chealey hit a driving layup to cut the lead to 45-35 with 14:20 to play.
But the Hurricanes answered with a 10-1 run of their own to open up a 20-point lead on Donovan Kirk's driving layup with 10:13 remaining.
The Cougars managed to cut the lead to single-digits, 62-53, on Anthony Stitt's 3-pointer with 3:08 to play, but could never get any closer.
"I felt like we competed with them the whole night," said Hall. "I'm proud of that. I felt like the score should have been closer because we played with them the whole night. If we had made a few more free throws, it might have been a different game."
The game against the defending ACC champions was part of the Wooden Legacy tournament, which the Cougars will take part in next week over the Thanksgiving holidays.


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Contact: +61 2 9514 1177
At the Special Needs Service, we can provide you with information about the support available across the university, inclusive practices and assessment arrangements.
You may not think of yourself as having a 'disability' or 'Special Need' but the definition under the Disability Discrimination Act upon which our service is based includes a wide range of health conditions such as:
- learning/neurological disabilities, e.g. dyslexia, ADHD/ADD, autism spectrum disorder
- medical conditions/ongoing illness, e.g. chronic fatigue syndrome, acquired brain injury
- mental health conditions, e.g. anxiety and depression
- vision, hearing and physical disabilities
- temporary injuries, e.g. broken arm
To help us provide your support in a timely way:
- make an appointment to register with us early, i.e. prior to the start of semester or before the census date
- contact us early if there's something we can help with
- keep in touch and let us know how you're going, and
- inform us about problems straight away.
We have a team of Disability Services Officers (DSO) who can be your central point of contact to discuss your needs and set up your:
- support services
- assessment arrangements
As part of your first appointment you will be referred to your faculty Academic Liaison Officer (ALO) who will work with you and your DSO and is responsible for approving recommended assessment arrangements, for example, exam conditions.
UTS is committed to providing equal opportunity for students with disabilities through an inclusive educational environment. We use the definition of disability in the Disability Discrimination Act 1992 (opens an external site), which covers a wide range of physical, sensory, psychiatric and learning disabilities, as well as ongoing illnesses. Both temporary and permanent disabilities are covered by the University's policies.
Your confidentiality is important to us, and we ask that you have a look at our privacy policy. You can also find equity-related policies, statements and strategies in a dedicated section.


text: The Massachusetts Human Stem Cell Bank and International Registry was established in 2007 at the University of Massachusetts Medical School. Developed with funding from the Massachusetts Life Sciences Center, the Bank and Registry is intended to serve as a resource for stem cell researchers throughout the world. This resource provides comprehensive information on pluripotent stem cells, high quality stem cell lines and state of the art training and educational resources.


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LISBON-Despite their winless start, the South Range Raiders had been competitive in several early season games and knew they were on the verge of playing good basketball. In the fourth quarter Friday night at Lisbon, they finally broke the ice.
The Raiders rode the hot shooting of guard Nick Wiery and stormed past the previously undefeated Blue Devils 58-49.
The Raiders improve to 1-5 overall and 1-4 in the Inter-Tri County League upper tier. It was the first win at the school for new head coach John Cullen. Lisbon drops to 6-1 and 4-1 ITCL.
"There is a lot of excitement with these guys right now," South Range forward Garrett Anderson said. "We came in thinking we could knock these guys off and we went out there and battled for it."
Wiery led the way with 19 points with 15 of those coming in the fourth quarter.
Lisbon opened the frame leading 34-30, but the Raiders unleashed their best offensive burst of the season to seize the lead. Wiery nailed three three-pointers to key the surge. One of those threes gave the Raiders the lead for good with five minutes left after a pinpoint pass from a double-teamed Anderson. His last three gave the Raiders a 47-38 lead with three minutes left and capped a 17-4 South Range run.
"He's had some nice games this year and he was on the verge of breaking out," Cullen said. "Tonight he put it all together."
"We doubled the post a few times when we shouldn't have and it left him (Wiery) open," Lisbon coach Chris Huckshold said. "We are big enough we didn't need to double and the way he was shooting you couldn't give him any space. We lost him a few times."
Anderson also played a huge role inside. The junior fought and scraped for every point and rebound against the taller post players of Lisbon and emerged with seven points and nine rebounds, including some key boards in the fourth quarter.
"He was a warrior tonight," Cullen said. "He was our backbone out there. They were throwing a lot of double-teams his way and he fought through it. He's one of those kids who just knows how to play."
"We are a little undersized compared to them," Anderson said. "Coach told us that all have players had to crash the boards and help with rebounding. Everyone hustled and did their part."
Point guard Mark Vennetti had a big second quarter to keep the Raiders within a few points and finished with 12 points and six rebounds. The 5-foot-6, 120-pound freshman held his own against 5-11 Lisbon point guard Josh Liberati. Vennetti began preseason thinking he would play on the freshman team, but was moved up to the varsity in late November and hasn't looked back.
"He got us out of the gate really well," Cullen said. "For being as small as he is he took care of the ball really well which was a big key for us."
The Blue Devils got off to a rough start when senior forward Matt Spencer, their primary post player, collected two fouls in the first two South Range possessions and spent the rest of the first half on the bench. Austin Rutecki led the Devils with 10 points and 10 rebounds. Liberati had 10 points and six assists.
"We can't use Matt being out as an excuse," Huckshold said. "The bottom line tonight was that we got outworked. We weren't focused and prepared and that's my fault. We missed a lot of close range shots and missed a lot at the foul line. Give Coach Cullen credit he had his team ready to play tonight."
The Blue Devils made a late run at South Range, closing the gap to five with one minute left, but sophomore forward Greg Dunham sealed it when he ripped an offensive rebound away from two Lisbon players, put the ball back in the hoop and was fouled in the process, causing the South Range bench to erupt.
"We've played well for periods of time throughout the year and it was just a matter of staying disciplined and focused for four quarters. Every time they made a run at us we stayed focused and got ourselves back under control it was just enough to hold them off."
The Blue Devils, though disappointed in their performance, know they are still well positioned in the league race, one game behind Springfield.
"It's one game and we'll learn and move on," Huckshold said. "It's a 22-game season. We still have a lot in front of us."
Game notes
Lisbon won the jayvee game 41-36. Colin Sweeney had 11 points for the Blue Devils. Mitch Dolak had 10 for the raiders. Jason Thompson scored the go-ahead bucket with 40 seconds left.
Four of South Range's five losses have come by nine points or less.
SOUTH RANGE SCORING: Mark Vennetti 4-2-12, Andrew Cullar 1-0-3, Greg Dunham 3-4-11, Robbie Matos 0-2-2, Garrett Anderson 3-1-7, Cole Berry 0-0-0, Jonah Wilson 2-0-4, Nick Wiery 6-4-19, Turner Curry 0-0-0. TEAM TOTALS: 19, 12-25: 58.
LISBON SCORING: Matt Spencer 3-2-8, Josh Liberati 3-4-10, Austin Rutecki 4-2-10, Avery Andric 5-3-15, Josh Craig 0-6-6, Austin Davis 0-0-0, Trevor Reese 0-0-0. TEAM TOTALS: 15, 17-25: 49.
Three-point goals: South Range 7 (Wiery 3, Vennetti 2, Cullar, Dunham), Lisbon 2 (Andric 2).


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- Text Size:
- ASmall Text
- AMedium Text
- ALarge Text
A 55-year-old former Kansas City man has been charged in connection with the 1996 slaying of a Raytown woman in an Andrew County cemetery.
Michael Ray Wilson has been charged with murder and robbery in Therese Campen's death.
Campen was found in a rural cemetery near Amazonia, Mo., where investigators said she had been killed.
Police said Wilson is currently in the custody of the Missouri Department of Corrections on unrelated charges.


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ACD Systems Apps now on the Mac App Store
Hey Mac and iPhone/iPad users!
In addition to ACDSee Pro photo editing and management software available through our own website at acdsee.com, we also have several ACD Systems apps available for download exclusively on the Mac App Store.
Visit iTunes to download these great apps:
ACDSee Duplicate Finder: Duplicate Finder goes right to work on your computer finding duplicate files, helping you free up valuable system space, improve performance and eliminate time-wasting digital clutter. It's like feng sui for your Mac, and it's available in English, French and German. $9.99
ACDSee: ACDSee was designed for photographers but is great solution for anyone who wants to get control of their digital assets. With ACDSee, you can manage your assets your way, rather than trying to adapt your workflow to fit the cataloging constraints imposed by other applications. Available in English, French, German and Japanese. $12.99
ACDSee Photo Flash: Use ACD Systems' patented Lighting and Contrast Enhancement to fix your dark photos in a flash. Regularly $2.99, now FREE for a limited time.
ACDSee Online: ACDSee Online's iPhone & iPad photo sharing app lets you show the world what you're seeing right now or share images from your ACDSee Online library. FREE


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End of the Road for North Korean Auto Maker?
An experiment in building cars in North Korea appears about to end, though it will do little to ease the world's oversupply of auto manufacturing capacity.
Pyeonghwa Motors Corp., a company started by the South Korea-based Unification Church in 1999 that runs a factory in North Korea, is planning to close, South Korean media reported Tuesday.
The North Korean government is a 30% partner in the car manufacturer.
A unit from the church's business arm spent about $55 million to build the Pyeonghwa factory in Nampo, a port city on North Korea's west coast about an hour or so outside of the capital Pyongyang. After the factory was completed in 2002, workers there completed partially built cars, in a form called knockdown kits, that were imported from manufacturers in Italy and China.
But the company appears to have rarely been profitable. In 2009, the firm earned about $700,000 from the sale of 650 cars. About $500,000 of that was remitted to its parent operation in South Korea. The South Korean government noted then that it was the first time a South Korea-based company repatriated profits from North Korea.
A representative at the Unification Church's business holdings didn't immediately return a call Tuesday.
Some news accounts said the church may invest in new businesses in North Korea, a step that would require approval from the South Korean government's Ministry of Unification. A spokeswoman at the ministry said no such request had been received.


text:
In honor of 2011
Video Music Awards announced last night, we're counting down MTV's most
extreme Moonman winners ever. Take a gander at which of your favorite musicians
love to shred and don't forget to vote for your favorite VMA
nominees. Maybe Tyler, the Creator or Justin Bieber will make this list next year.
#1 - Billie Joe
VMAs Won: 2005 Best Rock Video, Best Group Video, and Video of the Year
for "Boulevard of Broken Dreams"
Billie Joe
Armstrong has been a skateboarder as long as he's been the lead singer of Green Day. He left high school to pursue both in the late-'80s
and turned out to be more adept at music. However, he's still active in the
skate scene. His brother-in-law, Steve Nesser, is a pro skater. Armstrong is
also a playable character in "Tony Hawk's American Wasteland," along with Lil
Check out the full list at MTV: HERE


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"I'm definitely a fan of One Girl Cookie's whoopie pies – specifically their pumpkin whoopie pie with cream cheese filling," the actress told PEOPLE.
And Russell isn't the only one going crazy for whoopie pies.
Apple-caramel flavored treats from Wannahavacookie, an online retail bakery, have been spotted in Rachael Ray's office.
Meanwhile, Maine and Pennsylvania have been battling for months over which state created the classic treat. John Smucker, the co-owner of Bird-in-Hand Bakery in Lancaster County, Penn., knows why his bakery's dessert is so in demand right now.
"They're the perfect cake sandwich, the right combination of soft, moist cake and sweet filling," he says.
Eager to try a whoopie pie? Make one yourself:
Pennsylvania Whoopie Pie
Makes 18 pies
Preheat oven to 350 degrees. In a large bowl, cream together ½ cup vegetable shortening, 1 cups sugar and 1 egg.
Add 1 cup butter milk, 2 cups sifted flour, ½ cup sifted unsweetened cocoa, and 1 tsp salt. Mix well.
Add ½ cup water and 1 tsp. baking soda and mix until smooth.
Using a small ice cream scoop, drop batter 2 inches apart onto greased baking sheets. Bake for 12 minutes. Cool cakes completely before filling.
Mix 3 ½ cups confectioner's sugar, 2 tbsp. flour, 1 tsp. vanilla, 1 ½ tsp. lemon juice, ¼ cup milk, ½ cup vegetable shortening on low speed until blended.
Then mix on high speed until fluffy. Scoop filling on half the cakes, then cover with another cake.
Adapted from Bird-in-Hand Bakery's recipe


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Most everyone has heard of Julia Child (1912-2004). It was in Paris that Julia met two French women, Simca Beck and Louisette Bertholle, who were writing a cookbook aimed at an American audience. They needed an American collaborator. Julia was perfectly suited for the job. She began testing recipes. For nearly ten years, she devoted herself to writing, testing and re-writing. She confided to her sister-in-law: "Really, the more I cook the more I like to cook. To think it has taken me 40 yrs. To find my true passion (cat and husband excepted)."
She was invited to appear on a television program called "I've Been Reading", produced by WGBH, Boston's public television station. The host of the show was reluctant to take time for a subject as trivial as cooking. But Julia was undeterred. She arrived with a hot plate, giant whisk and eggs, and made an omelet. Twenty-seven viewers wrote to the station, wanting to see more. The station produced three pilots, then launched into production of The French Chef. Produced and directed by Russ Morash, the series broadcast a total of 199 programs, produced between 1963 and 1966.By the end of 1965,
The French Chef was carried by 96 PBS stations. Sales of Mastering the Art of Cooking" were picking up speed – 200,000 copies sold. In 1965, Julia won a Peabody. In 1966, she won an Emmy. Time put her on the cover in a feature article on American food – "Everyone's in the Kitchen."
But this series is not about Julia, although America will miss her, it about Romaine Chatard Champion, the author of of the book "The Art of Cooking Omelettes" published in 1963.
Madame Romaine was born in Lyon and grew up working in her parents' restaurant. She learned everything from her mother who was 'an instructive cuisinère, and saw to it that I learned in proper order: first principles; then recipes; and, finally, style.' Madame Romaine lived in Lyon until she married, at a very young age, and moved to New York City with her new husband. She spoke no English whatsoever when she arrived in the US and took a bit of time building up confidence to do so. While still very young, her husband tragically suffered a heart-attack and died. Madame Romaine was then left wondering what to do and eventually opened a Salon de Thé in Manhattan. Her eventual location was at 156 East 56th Street, which is now an Antiques shop.
Beginning in May Mike the Chef and co-owner of the William Miller House will begin preparing one of the 500 different style omelettes from Madame Romaine's book. We will begin with the cheese omelettes, and on to tomato, if the timing is right and so on. I promise you each will be a delight and we will ask that our guests leave comments here on the blog so that you may draw you own conclusions as to whether or not to try a particular omelette. We promise to alert you if the omelettes are falling into one of the less well know culinary areas of liver, kidney, sweetbreads, etc. I figure with 500 omelettes it will take over 8-years to complete the effort as this should not be a problem. In the case of the more obtuse items Mike and Pat may choose to have those for dinner on Monday night and invite the neighbors, should they be so brave.
Here is the beginning of the journey:
Cheese Omelettes (Omelettes au Fromage) NOTE:The cheese will always be swiss cheese in keeping with the recipes
GUIGNOL (onion, cheese)
PARMENTIER (potatoes, cheese)
CHAMBERY (potatoes, onions, cheese)
LAURENTIENNE (fines herbes, cheese)
DAUPHINIOSE (potatoes in cream sauce, cheese)
VALENCIENNES (onions, peas, croutons, cheese)
AELEGEOISE ( onions, spinach, rice, cheese)
CHOISY (peas, onions, rice, parsley, cheese)
ARGENTEUIL (asparagus, parsley, cheese)
FONTAINEBLEAU (eggplant, garlic, fines herbes, cheese)
MORNEY (tomatoes, croutons, fines herbes, cheese)
BRESSANE (croutons, CREAM SAUCE, cheese)
LORRAINE (chives, bacon fines herbes, cheese)
LIMOUSINE (potatoes, bacon, fines herbes, cheese)
BEAUVILLIER (bacon, crouton olive, cheese)
FRANCHE-COMTOISE ( asparagus tips, bacon, parsley, cheese)
DAUPHIN (bacon, spinach, croutons, cheese)
ROCHAMBEAU (sausage, spinach, mushrooms, cheese)
BAMBOCHE (chicory (curly endive), croutons, bacon, garlic, cheese)
DUMONTEIL (carrots, onions, bacon, fines herbes, cheese)
CHAMPENOISE (oyster plant, rice, parsley, CREAM SAUCE, cheese)
AURILLIC (oyster plant (salsify), bacon, croutons, noodles, cheese)
MONTPELLIER (cauliflower in CREAM SAUCE, croutons, cheese)
COLMAR ( cauliflower, bacon, croutions, cheese)
FANTASIO (apples, croutons, walnuts, cheese)
MARGOT (truffles and cheese)
Tags: Breakfast Recipes, Dining, Famous Chefs, Omelette Mondays, Richmond Bed and Breakfast, Travels in France


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on May 23, 2013 - 11:54 PM
, updated May 24, 2013 at 9:04 AM
Democracy broke out in a Town of Tonawanda gymnasium Thursday as more than 80 people brainstormed about how to spend money from a potentially hefty fine that could be imposed on an industrial polluter.
Most of the people there were nearby neighbors of Tonawanda Coke, which in late March was found guilty of 14 counts involving violations of the Clean Air Act and Resource Conservation and Recovery Act over 11 years, including the excessive discharge of coke-oven gas that contains cancer-causing benzene.
A mostly working-class crowd gathered in the Boys & Girls Club of Town of Tonawanda, discussing issues around tables in small groups, jotting down ideas on Post-it notes sorted onto colored poster board with various headings, and sharing highlights with the larger group.
It was the first session in a several-stage process to let local residents have their say in how resources could be put to use to reduce the adverse impact of air pollution and land contamination, and improve the public's health. U.S. District Chief Judge William M. Skretny could fine Tonawanda Coke up to $200 million at sentencing July 15. Twenty-five percent of that could be used in the community to address environmental concerns.
"I'm from the City of Tonawanda, and getting people to come together like this – the ones being affected – and actually give their ideas was great," said Lindsay Amico.
"Some of the ideas were good, and some somewhat unworkable, but it was a good starting point," said Anne Matjeka, a Town of Tonawanda resident.
Matjeka praised the Clean Air Coalition of Western New York, which organized the participatory budgeting exercise in democracy in use in other countries and several municipalities in this country, and community organizer Rebecca Newberry.
"I can't believe how organized they are," Matjeka said. "Rebecca is changing our world."
Newberry said she was pleased to see people engaged who often aren't asked to participate significantly in political activity.
"The thing with this kind of meeting is that sometimes it can get a little messy, but I think sometimes the messier democracy gets, the better," Newberry said. "By 'messy,' I mean there are lots of different ideas, and not everybody agrees, but the idea is to get them all on the table and have an honest conversation."
Potential projects must reduce adverse effects to public health of air pollution or land contamination, without duplicating projects mandated or funded by the federal government, or legally required to be done by Tonawanda Coke.
As the two-hour session proceeded, numerous ideas emerged:
Identifying sources of air pollution. Testing open and closed landfills. Building new parks. Establishing an environmental health center. Creating a pollution museum with monitoring devices.
Also, offering educational forums on the dangers of pesticides. Conducting independent air-quality testing. Converting River Road into a parkway.
Some ideas, such as increasing mass transit, were put under a category of projects that the government would need to do.
Erie County Legislator Kevin R. Hardwick, R-City of Tonawanda, suggested that what was on display was a more pure form of democracy than what occurs within the Legislature. "This was a lot more meaningful, a lot more sincere," Hardwick said. "When people spoke, it was coming from the heart."
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Ryobi One+ Paint Sprayer P620 - BARE
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This powerful cordless Ryobi ONE+ paint sprayer is ideal for painting interior and exterior surfaces like walls, fences and sheds. It comes with a 1L spray pot and 3 spray patterns to cope with a variety of surfaces - round, horizontal and vertical. A flexible intake tube lets you spray at any angle and use the last remaining paint in the container minimizing wastage. It is supplied with batteries sold separately and is compatible with Ryobi One+ batteries.
- Guarantee - 2 year
Features and Benefits
- Innovative and patented delvery system minimises the need for dilution
- Choose between 3 spray patterns, horizontal, vertical or round to provide with best coverage
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Officejet 6700 CN583A Premium Wireless e-All-in-One Inkjet Printer, Copy/Fax/Print/ScanItem#: H24-30314 | Model#: CN583A#B1H
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HP Officejet 6700 CN583A Premium Wireless e-All Product Details
HP Officejet 6700 CN583A Premium Wireless e-All
Wireless e-all-in-one inkjet printer delivers professional color you can count on for a low cost per page. Print from a variety of mobile devices with HP ePrint. Finish projects fast and save time, thanks to the 35-page automatic document feeder and 250-sheet paper tray. Use the 2.65" touchscreen to access apps and manage print jobs directly at the e-all-in-one. Create a one-sided copy of a two-sided ID, and use the CopyCrop tool to modify copies. Improve workflowsend quick faxes or scan documents to a PC, e-mail and more. Consume less paper with automatic two-sided printing, plus easily preset the e-all-in-one to turn on or off for energy savings.
What It Is And Why You Need It:
- Up to 4800 x 1200 pdi of visually impressive prints.
- A transfer rate of 3 sec per page.
Package Contents:
- HP Officejet 6700 Premium e-All-in-One Printer: Setup supplies (inkjet cartridges, 4 each)
- shopping card
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- Getting Started Guide.
Additional Resources: Product Manuals
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This Shimano XT Traditional Double Front Derailleur FD-M786 is a traditional styled (bottom-swing) front derailleur. It has been designed to optimize its function with two chainrings. To this end, the cage length and shaping is specific to the smaller diameter differential between the big and little rings on a 2x10 DynaSys drivetrain. Whether you run a 26/38t or a 28/42t crank, this is the changer you'll want. The limit screws are angled outward to facilitate adjustment for convoluted rear suspension designs as well.
The Shimano XT Traditional Double Front Derailleur FD-M786 is specifically designed for use with Shimano's XT Double Crankset and directional 10-speed HG-94 chain, and the maximum chainring size is 42 teeth. The big difference between this derailleur and the triple-compatible version is that this one has a shorter cage. Using it with an XT triple crank would result in the chain dragging across the bridge at the bottom of the cage in many of the rear cogs when you ride in the 24t small ring. It can be used with top- or bottom-pull cable routing. It has a Multi-Clamp that works for three seat tube diameters (28.6, 31.8, and 34.9mm).
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How do you run the cable on this for bottom pull? The Shimano instruction manual seems to show a piece that isn't there (to loop the cable over the clamp)
Will this work with a triple crankset that...
Will this work with a triple crankset that is set up with two rings and a bash guard? (34t, 24t, and bash)
Everthing a 2x should be
Lightweight, solid, shifts fantastically. No complaints at all.


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Top Definition
Short for welcome back.
Person 1: Okay, I'm back.
Person 2: Weba :D
Person 1: Thanks. C:
Person 2: Weba :D
Person 1: Thanks. C:
de iHateYouAllx 23 Iunie 2011
Trending Now
Can you define these popular missing words?
Shortened version of 'Welcome back.'
We(lcome) ba(ck)
We(lcome) ba(ck)
"Heya Anabel! Weba!"
de Raveh 27 Februarie 2006
Short for We Eat Boob Addicts
Person 1: Hi i'm new around here.
Person 2: Thats fine just remember, Weba
Person 1: Okay.
Person 2: Thats fine just remember, Weba
Person 1: Okay.
de guttalingur 14 Decembrie 2012
Acronym for Will Eventually Be Attractive, more commonly known as 'jail-bait'. This word is most frequently used to not seem 'creeper' in public situations.
Molly Cyrus, aka Hannah Montana, is quite a Weba.
de Timmy J J 04 Aprilie 2009
spanish slang used in mexico to describe a state in which a person has a complete lack of interest and/or energy to proceed in an activity, normally the activity is sugested to the person ; this is called weba because it derives from huevos which is eggs but it has been turned into the slang webo which sounds the same in spanish finally turning into weba ,called like this because supposedly the male eggs (testicles) are to big at the moment impossibiliting any activity
pedro:wey, vamos al cine
raul: no cabron q weba
pedro: man, lets go to the movies
raul: no man i have WEBA
raul: no cabron q weba
pedro: man, lets go to the movies
raul: no man i have WEBA
de papantla flyer 21 August 2006


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Americans have finally come around to soccer: Since the World Cup last convened in 2010, the number of U.S. adults who have watched, attended or listened to a major soccer match has surged by 32 percent. Or, to keep the math closer to home, just count the number of jersey-clad fans staggering down Charleston streets after a U.S. match.
But the World Cup's return brings with it a few reminders of why Americans were holdouts for so long. Namely, the ties. Such an ambiguous outcome might make sense in a country that's spent thousands of years winning and losing battles, but Americans like their victories clear-cut. We haven't yet matured to the point where we can see the beauty in a final score of nil to nil.
Really, a finish like that just stymies our primary spectating objective, which is to figure out who's best. Who's the best passer? The best defender? The best coach? When the scoreboard reads 0-0, who knows?
I'm often guilty of approaching obscure restaurants the same way: While I know the restaurant's unlikely to excel in every category, I'm keen to find the best pizza crust, or the best chicken gravy, or the best horchata. It doesn't really matter what the restaurant does best, so long as it has more to offer than an OK plate of food.
It was fitting, then, that I was at Brazilian Buffet & Bakery yesterday for the Brazil-Mexico match, which ended in a 0-0 draw. Everything about the stripped down restaurant was fine, but my efforts to unearth a superior dish - the kind that would make me want to send you to Goose Creek right this second -- flopped.
Brazilian's yellow-walled dining room is minimally decorated: If patrons notice anything about their surroundings, it's likely to be the florescent lighting and faulty air-conditioning. There are a few plastic-wrapped sandwiches and beige pizza slices idling in the cooler, but every customer I saw headed straight for the $10 buffet.
Sliced fruit and pasta salad open the buffet, but the steam table veers off in a meaty direction. Just past the spiky white rice and beans (pinto and black), there are crusted slabs of mild white fish; stewed chuck steak; salty chicken thighs and fried pork nubs. Thickly-sliced plantains, shimmering with frying oil, occupy the final spot.
The fish was by far the prettiest item in the line-up, but the black beans benefitted from the most thoughtful seasoning: They were woodsy and garlicky. If I hadn't planned on ending my meal with a major pastry order, I would have had seconds. Only the beef disappointed: It was tough (and, while we're on the topic, a coconut cake was distractingly dry, although I really liked a soft, jam-filled cookie. The dozen or so very quiet fans who gathered for the game seemed to prefer watermelon for dessert.) Everything else tasted pretty much as expected.
While chewing the beef, I had a chance to examine the housemade hot sauce at the center of the table. Stoplight red, the dense, vinegar-based sauce had a fruity flavor, although the cashier assured me it didn't include any fruit - just "Brazilian chiles." I'm guessing she meant malagueta peppers, the popular Brazilian pepper that's twice as hot as cayenne. The sauce was terrific - even if it wasn't the best hot sauce I've ever had.
Brazil's national team returns to the field next Monday at 4 p.m. Brazilian Buffet & Bakery is located at 1258 Red Bank Rd.
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