text:
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
As Immunotherapy Revolutionizes the Cancer Treatment...
Expanding Use of NGS Has Largely...
A new weapon in the battle against breast cancer may be on its way. Researchers from the Scripps Research Institute (TSRI) have identified a mechanism through which mitochondria control tumor aggressiveness. The team says they've developed a treatment that inhibits cancer progression and can prolong life when tested in mice.
The TSRI laboratory of associate professor Brunhilde H. Felding, Ph.D., studies cancer, especially the mechanisms that control metastasis. Past research suggested that mutations affecting mitochondria, which are key to energy production in cells, strongly influence whether a tumor becomes aggressive, but the mechanism was not clear.
"We decided to investigate a specific protein complex, called mitochondrial complex I, that critically determines the energy output of cellular respiration," said the study's first author, Antonio F. Santidrian, Ph.D., a research associate in Dr. Felding's laboratory. To do this, the group partnered with Akemi and Takao Yagi at TSRI, who specialize in complex I research. Using reagents from the Yagi group, the Felding team discovered that the balance of key metabolic cofactors processed by complex I—specifically, nicotinamide adenine dinucleotide (NAD+) and NADH, the form it takes after accepting a key electron in the energy production cycle—was disturbed in aggressive breast cancer cells.
To find out if the balance of NAD+ and NADH was critical for tumor cell behavior, the team inserted a yeast gene into cancer cells that caused a shift toward more NAD+. This shift caused the tumor cells to become less aggressive. To confirm and extend the initial findings, the team altered genes tied to NAD+ production. The resulting shift again showed that higher NADH levels meant more aggressive tumors, while increased NAD+ had the opposite effect.
The team then sought out a way to enhance the critical NAD+ level therapeutically by exploring what would happen if mice with breast cancer (of the transgenic MMTV-PyMT model) were fed water spiked with nicotinamide, a precursor for NAD+ production. The scientists found that enhancing the NAD+/NADH balance through the nicotinamide treatment inhibited metastasis, and the mice lived longer.
"In animal models at various stages, we see that we can actually prevent progression of the disease," said Dr. Felding.
Now the group is working toward human trials to learn whether nicotinamide or other NAD+ precursors will have similar results in humans. Since NAD+ precursors are already used for other purposes, such as controlling cholesterol levels, the team hopes that achieving approval for human clinical trials will be simpler than is normally the case.
"It is not a totally new treatment that would need to be tested for toxicity and side effects like a new drug," said Dr. Felding. "And we already know the precursors can be easily ingested."
The team says that such a treatment, should it prove to be as effective in humans as it is in mice, could benefit people at risk of developing aggressive breast cancer, offer complimentary treatment to chemo and radiation therapy to avoid disease recurrence, and maybe even provide a preventive treatment for women with a family history of breast cancer.
The team describes its results in an article published online ahead of print by the Journal of Clinical Investigation titled "Mitochondrial Complex I activity and NAD+/NADH balance regulate breast cancer progression".
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Pols' Picks: Who Will Win the Senate?
Related Video: The Battle for the U.S. Senate
The biggest political question between now and November is whether Republicans can win the six seats necessary to take control of the Senate.
You've seen the predictions and forecasts from the likes of Nate Silver, Stuart Rothenberg and the New York Times, and today Washington Wire is introducing the first installment of our political prognostication panel.
We've gathered a group of pols inside and outside of Washington to gauge the odds of a GOP Senate takeover and the number of seats each party will control after the elections. Our panel includes veterans from past presidential campaigns as well as other political veterans.
Of the group, the most optimistic Democrat is strategist Hilary Rosen, who gives 25% odds of a GOP Senate takeover. Former Harry Reid aide Jim Manley gives Republicans a 50-50 chance of taking control of the Senate.
Among Republicans, the range is between former NRSC aide Brian Walsh giving the GOP a 55% chance of winning control and former Mitt Romney aide Katie Packer Gage's 80%.
No one in our panel predicted Democrats will hold more than 53 seats – with that figure down two seats from the 55 they control now – and Florida GOP strategist Rick Wilson owns the high-water prediction for Republican-held seats at 54, up from 45.
Note: For our purposes, we're assuming the Senate independents Angus King of Maine and Bernie Sanders of Vermont will continue to caucus with the Democrats, though it is feasible that Mr. King could flip if the GOP wins control.
Below is the first set of calls. You can re-sort the picks by clicking on the column headers.
We'll be checking in with our panelists periodically between now and November and will follow how their predictions change as the campaigns proceed.
Sign up for the Capital Journal Daybreak newsletter: http://on.wsj.com/CapitalJournalSignup
Download the free e-Book "The Right Way? Republicans Rethink, Reload for 2014" for a new essay by Gerald F. Seib and a collection of The Wall Street Journal's coverage of the Republican Party's effort to reclaim both houses of Congress in 2014.

subset: commoncrawl


text:
EAST LIVERPOOL - The transfer of the former East Junior High School building from the school district to the city is now complete, and plans are in the works to develop the property.
Superintendent James Herring, Treasurer Todd Puster, buildings and grounds Director Mark Reed and city Service-Safety Director Ryan Estell toured the building recently.
The exchange of city-owned property on Pope Street to the school district is still pending, awaiting finalization of legal paperwork, according to Estell. The school district will use the property, which holds the now-empty city reservoirs, for additional parking for high school events.
Article Photos
One of many classrooms in the former East Junior High School building in East Liverpool gets the once-over by (from left) city Service-Safety Director Ryan Estell, school district buildings and grounds Director Mark Reed, Treasurer Todd Puster and Superintendent James Herring. (Photo by Jo Ann Bobby-Gilbert)
the officials' tour proved somewhat nostalgic as Herring recalled the days when it played host to "the biggest junior high school game in the area" between the East Junior Panthers and Westgate Wildcats.
The school, built in 1954-1955 was used until the early 1980s as the junior high, then by the Ohio Valley Business College before being turned over in the mid-1990s for use as the district's administrative offices.
Those offices were relocated to the Westgate complex due, in part, to the need to renovate the Maryland Avenue building.
Nonetheless, during their walk-through, officials pointed out the still-viable aspects of the 50,000-square-foot building, including the terrazzo tile floors and glazed tile walls that are still pristine, if in need of some buffing.
"Back in the day, a lot of that went into this building, and a lot of money," Puster pointed out, referring to the expensive cost of such materials at that time.
"It's sad. They don't build buildings like this any more," Herring agreed.
Reed added, "There's a lot of history here."
In addition to the top-quality materials used in its construction, the building still boasts some of its original classroom amenities, such as deep wooden drawers in a sewing cupboard in the former home economics room and an unusual floor in the wood shop made from boards sank six inches into the ground, leaving the highly-grained ends looking like brick.
The gym floor is still as scratch-free as the last time a basketball game was played on it, and the motorized bleachers still work, officials pointed out.
Throughout the building, mementoes were piled up, ready for relocation to other buildings, including a collage of photos that included students lost too soon in accidents and in Iraq.
The cornerstone plaque will be donated to the East Liverpool Historical Society, Herring indicated.
A room dedicated to air monitoring by the Environmental Protection Agency will be moved to a station in the yard, according to Estell, who said the agency will pay for that, not the city or school district.
Although classroom floors have asbestos tile, officials said there is no issue with it unless it is removed or gets wet. Estell said an asbestos hazard report was completed in August and nothing more will be needed for three years.
With the deed now transferred, the city will assume the cost of maintaining and heating the building, and Estell said it has been added to the city's insurance policy, with all unnecessary water and electrical breakers shut off.
Reed will monitor the boilers until all school district files and other belongings are moved out, he added.
The city has been in discussions with a company interested in purchasing the building, and Estell said, "We're trying to work with the state Department of Development and other agencies to find funding to help repair it. My belief is, if we can get state assistance, this company will be in here as soon as possible."


text:
|ALS Collaborative Postdoctoral Fellowship Program
Fellows will have access to a valuable combination of outstanding professional scientific and engineering staff, research instrumentation, and other facilities available at the ALS, as well as potential access to other LBNL user facilities including the Molecular Foundry, the National Center of Electron Microscopy, and the National Energy Research Scientific Computing Center.
ALS Collaborative Postdoctoral Fellowships normally provide only partial salary support. Applicants must contact one or more ALS staff members to discuss areas of common research interest, to agree on a potential research project, and to locate sources of collaborative funding, possibly through an external postdoctoral advisor, a collaborating LBNL division, or an external fellowship.
A monthly salary will be paid at a rate competitive with current ALS postdoctoral fellows. Additional funding support will be available for research-related materials, supplies and services, professional development, and research-related travel. Postdoctoral fellows are also eligible for mid-level career benefits.
Program Objectives
The ALS Collaborative Postdoctoral Fellowship program seeks to identify outstanding individuals who will collaborate closely with ALS staff and users in new and emerging scientific and engineering research fields. The program will provide advanced training for careers paths that involve x-ray instrumentation and synchrotron radiation science. We are particularly interested in identifying outstanding scientists from historically underrepresented groups.
Applicants must be legally eligible to work in the United States, regardless of citizenship, and have received a doctoral research degree from an accredited academic institution in an appropriate scientific or engineering discipline in the three years before the appointment start date. Awards are initially for one year with the possibility of renewal for a second and/or third year, contingent on satisfactory annual performance reviews and funding availability. Renewals will be evaluated at the end of each year.
All contingencies of an appointment offer must be met before the Fellowship term begins. If an award is offered to a doctoral degree candidate, the candidate must present acceptable evidence that all formal academic doctoral degree requirements have been met before starting the fellowship.
As noted above, individuals interested in applying for a fellowship should start by contacting one or more ALS staff members (see ALS Beamlines Directory for beamline information and associated scientists) to discuss possible projects and to identify external sources of matching funds. Applicants must then submit a completed ALS Collaborative Postdoctoral Fellowship application online via Berkeley Lab's Current Job Openings web site (requisition 77677) that includes: an application form, C.V., publication list, statement of research to be performed (up to 3 pages), and three references.
Selection Procedure and Criteria
All Fellowship packets will be received, processed, and reviewed by the ALS Postdoctoral Fellowship Committee. Applications are reviewed on a quarterly basis. Applications will be evaluated based on the qualifications of the applicant, the merits of the proposed collaborative research, and the alignment of the project with ALS strategic priorities.
Fellowships involve a full-time commitment to the research program, and the fellow must be in residence at ALS/LBNL during the entire period of the fellowship. Fellowship research must be conducted in accordance with a plan that meets the overall research needs of the ALS.
Fellows are required to sign and abide by the appointment letter, the terms of appointment, and other required ALS/LBNL policies. They are also required to submit a final report of research accomplishments to the ALS, acknowledge the support of ALS/DOE/BES in publications and presentations related to research conducted during the fellowship, and submit these publications to the ALS publication database.
For More Information


text:
Top Definition
A very gay kid. He can be found getting pounded by husky, leather-wearing gay men. He also loves the menorah and the gringos. He lives in Sandwich Ma, and also has been known to pound butt as well as receive
That kid is so gay, he must be trying to become the next Dullivan
מאת wbucklax 15 בפברואר, 2004
Trending Now
Can you define these popular missing words?


text:
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
Despite new heights of process characterization and knowledge, scaleup still can befuddle the most experienced of bioprocessors.
Wei Chen, Ph.D., chief scientist at Phage Pharmaceuticals, believes that a disconnect between early-stage R&D and manufacturing—a defect that has persisted since biotech's earliest days—is one culprit.
"Companies have come a long way in streamlining clone selection and expansion, but this activity more closely resembles basic research than manufacturing," he says. "Cells at this stage have almost no chance of surviving in a large culture in the manufacturing environment."
The analogous activity in small molecule development, the handoff of an investigatory synthesis route to process development, suffers from far fewer sharp breaks.
Dr. Chen blames both development "silos" and the complexity of biological systems for the discontinuity.
"Particularly as companies grow, the various activities like early clone selection, cell-line engineering, expansion, scaleup, and production become compartmentalized. At larger scale many more variables are operational," he explains.
While small molecule development teams may re-work a synthetic pathway for lower cost or scalability, scaleup becomes a straightforward chemical engineering problem once the manufacturing process is set. In biotech a cell's response to media and feed, dissolved gases, waste products, and the myriad stresses of the bioreactor environment are far more complicated than heat and mass transfer in chemical reactors, particularly at significantly different scales.
Dr. Chen suggests an approach involving reverse-engineering the larger process by getting more large-scale parameters into the picture very early in development. "But in most large biopharmaceutical companies this is next to impossible, as cell biologists lack manufacturing expertise and process development and manufacturing specialists know little about cell biology," he points out.
The other issue Dr. Chen mentions as hampering scaleup is the lack of industrialization and standardization of bioprocesses for therapeutics. While we hear of "platform" processes for certain expression systems and products (e.g., CHO cells and monoclonal antibodies), experts still view many cell culture processes as unique protocols. Hence the intellectually suspect adage, "The process is the product."
This philosophy seems to repeat in history. Commercial wine-making began with a similar philosophy based on hand-made, empirically individualized recipes. "But today all top wine-makers have standardized their processes, so that the quality of the product can be maintained," says Dr. Chen. Bioprocess scaleup's success depends on the integration of biology into engineering.
Introducing new processes into a busy, established facility poses significant logistical and technical challenges, according to Gregory R. Naugle, director of process development at Amgen's West Greenwich, RI, production facility, the largest in the Amgen manufacturing network. Key issues involve ensuring the new product's success while not rocking the boat with respect to existing processes.
Tech transfer of multiple products at differing stages of development and scaleup add to the complexity, maintains Naugle. "A high run rate facility runs continuously, and provides very little 'white space,' with very little free equipment. There are limited windows of opportunity to modify equipment to accommodate the new product or process."
The top priority should be maintaining the fidelity of the currently licensed process. "When you modify shared equipment, you want to ensure you're not altering the process that's already there," Naugle adds. "In essence, you want to change something without changing it. If the modification involves hardware, for example piping or the diameter of a transfer panel, you must assure there are no unintended consequences to the existing product."
Synchronicity is what complicates tech transfers into busy plants. Under circumstances where projects enter sequentially, one is able to conduct a full "lessons learned" and still have time to prepare for the next project.
"When they're happening simultaneously or nearly so, you don't have the decompression time to do a lessons learned, implement those learnings, and move forward," says Naugle. "You need to transmit that knowledge very rapidly."
Again, the confounding variables concern the fact that cells are living organisms that are significantly affected by environmental factors.
Moreover, with high-run facilities, the operational distinctions between scaleup and tech transfer become more semantic than substantive. Both involve freeing resources for the new process and assuring the integrity of existing processes. "It's just the nomenclature we choose to use," Naugle, says. "If we scale up from a pilot facility in a different building we don't consider that a tech transfer because of the co-location. But if the process were coming in from Amgen headquarters at Thousand Oaks, it would be considered a tech transfer. So yes, scaleup presents many of the same challenges as a full tech transfer, particularly when you're talking about maintaining the fidelity of the existing process."
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
A former inmate at Huttonsville Correctional Center was arraigned for allegedly bribing a correctional officer to smuggle tobacco into the prison Wednesday in Randolph County Circuit Court.
Randall Beatty, 26, of Mineral Wells, pleaded not guilty to two felonies - bribery in official and political matters and conspiracy to commit bribery in front of Judge Jaymie Godwin Wilfong. After being indicted in February, Beatty was scheduled to appear for bond return March 6 in Circuit Court, but when he failed to do so, Wilfong issued a capias.
On Wednesday, however, Beatty appeared voluntarily with his attorney, Matthew Fair.
"He did not receive information about the arraignments until after the arraignments appeared in the paper," Fair told Wilfong, who ordered that the capias be vacated.
Beatty was named in two counts of a 19-count indictment also involving Paul Edward Bibbee, 47, an inmate at Huttonsville Correctional Center, Alston W. Jackson, 49, of Buckhannon, and Ralph Richard Morgan, 37, an inmate at Huttonsville Correctional Center.
The indictment alleges that Beatty bribed Jackson - who, at the time, was employed as a Huttonsville correctional officer - to smuggle tobacco into the prison on April 12, 2012.
Also in Circuit Court Wednesday, Wilfong granted a defense motion for continuance in the case of 32-year-old Kristie Dawn Martin of Harman. Wilfong issued a capias for Martin after she failed to appear at a Jan. 30 sentencing hearing on third-offense shoplifting charges.
Martin was taken into custody March 7. Martin's attorney, Matthew Fair, asked for a continuance in light of the fact that his client is facing more serious charges in Upshur County that could result in a sentence of three to 15 years in the state penitentiary, he said.
"To be frank, your honor, if she's sentenced to three to 15 years, I'm going to ask that this sentence (from Randolph County Circuit Court) run concurrent to that sentence," Fair asked.
Wilfong said he could make the same request in Upshur County Circuit Court should Martin be sentenced in Randolph County first.
"Let's just set it for the next available date," the judge set.
Deeming her a flight risk, Wilfong revoked Martin's bond and set a sentencing hearing for 9 a.m. April 16.
Contact Katie Kuba by email at firstname.lastname@example.com.


text:
Featured Products
Take advantage of Negative ion technology and remove pollutants as small as 0.01 micron. Negative ions the best coverage there is against pollutants.Read More
An Ideal air purifier that combines seven proven air purification technologies to effectively remove virtually all types of pollutants including dust, odours and micro-organisms.Read More
Best solution for those dry days of the year, hassle free operations with large tank. Incorporating the cutting edge negative ion technology for a healthier indoor environmnetRead More
Dehumidifier makes use of state of art Peltier (Thermo Electric) Technology to offer whisper quiet operation and light weight to provide ultra-portability.Read More
Flexible kneading discs specifically designed to create a professional massage experience for your feet, ankles and calves at the same time.Read More
Experience the ultimate aromatherapy experience at a comfort of your home from this little sleek device without any heating element.Read More
Water is life; enhance the quality of life with Heaven Fresh Water Purifiers, providing chlorine free, healthy, mineral rich water source for your family.Read More
Get peace of mind with a vast verity of reliable and efficient Heaven Fresh household products, providing ease and comfort in today's busy life style.Read More
- HF 610 Filter
- HF 290 HEPA Filter
- HF 290 Activated Carbon filter
- HF 290 UV Lamp
- HF 310A HEPA Filter
- Filter - HF-758
- HF 380 Carbon & Hepa Filter
- HF 380 Dust Collection
- HF 380 UV Lamp
- Replacement TiO2 Filter for NaturePure HF 380 / HF 380A
- HF 280 Carbon & Hepa Filter
- HF 280 Dust Collection
- HF 280 UV Lamp
- Replacement plate for HF 210UV
- Replacement UV lamp for HF 210UV
- HF-210uv-Front Grill
- HF210uv Adapter
- HF 300C Hepa Filter Old
- HF 300C Hepa Filter
- Replacement TiO2 Filter for HF 300
- Replacement UV lamp HF 300 C
- Replacement Plate for HF 200
- HF200 Adapter
- Filter Cartridge for AK-900
- Cleaning Filter for AK-900
- HF501 Shower head Filter Cartridge
- HF507 Shower head Filter Cartridge
- HF100 Adapter
- HF88 Filter
- HF88 Adapter
Benefits of Negative Ions
Air ionisers wipe out hospital infections
Read More >>
Ozone Sanitizer Air Purification
Read More >>
Importance of Negative ions
Read More >>


text:
GoDaddy's latest and truly tasteless Super Bowl ad provides a fascinating case study on the positive power of negative reaction. Viewers hated the ad, according to every metric. GoDaddy scored big on the most important metric–sales.
You remember the GoDaddy Super Bowl ad, the one featuring a nebbish–a tech nerd– engaging in a graphic make-out session with supermodel Bar Refaeli. The 30-second spot scored dead last among all Super Bowl ads across almost every informal poll and Twitter sentiment analysis. The "Kiss" ad wasn't just bad or boring -- the advertisement actively offended viewers, sending many of them to their second screens to immediately document their outrage.
Sounds like a real waste of $3.8 million for 30 seconds, right? Guess again. The day after the ad ran was GoDaddy's most successful sales day ever, according to data shared with the tech blog Mashable. Not only did the ad convert impressive sales revenue, it allowed GoDaddy to make significant headway in pursuit of the modern marketer's current reigning Holy Grail–mobile sales.
Breaking down the metrics of a borderline-sexist GoDaddy Super Bowl ad might sound about as appealing as performing an autopsy on a hagfish. Nonetheless, there are some interesting lessons here in creating negative consumer sentiment on purpose and then leveraging that negative sentiment into record sales revenue.
The GoDaddy "Kiss" ad aired at 6:46 p.m. ET, about 15 minutes after the game's kickoff –a premium ad spot. The spot lasted only 30 seconds, but to many of us it felt like we were watching those two kiss for about an hour. The graphic close-up shot seemed to go on and on, irritating millions of viewers in the process.
The social media reaction was swift and overwhelmingly negative. The social metrics analysis firm Whispr Group found the ad generated more than a quarter million tweets–86 percent of which were negative reactions, rendering "The Kiss" the most disliked of any of the ads by far. "The Kiss" came in dead last in viewer-submitted rankings on the "Best Super Bowl Commercial" lists compiled by USA Today and Wall Street Journal readers.
There were no morning-after regrets at GoDaddy. The web hosting service enjoyed its biggest sales day in history Monday, with 10,000 new customers overall. Hosting account sales were up 45 percent over a comparable period last year and their share of mobile customers increased by 35 percent.
Granted, GoDaddy is just cherry-picking their best data for press release purpose, but those are some very good cherries to have available for picking.
Compare the value of these statistics to 2011, when GoDaddy was toting the biggest spike in web traffic of any Super Bowl advertiser. Web traffic is great, but you don't have to work on Madison Avenue to realize that web traffic does not necessarily equal dollars. Those GoDaddy post-Super Bowl sales figures are missing some key context, but each of them does represent penetration into coveted market segments.
The "Kiss" ad generated hundreds of thousands of tweets, the most insightful of which comes from ESPN sports and business reporter Darren Rovell. "The USA Today ad meter has the GoDaddy 'Kiss' ad as the worst commercial in the entire broadcast," Rovell tweeted. "Likely was most effective."
Delivering the most successful Super Bowl ad their client has ever enjoyed, "The Kiss" ad producer Deutsch, Inc. won't get much lip from GoDaddy about all those "worst commercial" complaints.
This article is part of Allvoices' series on ad:tech, the largest, longest-running digital marketing and technology event. Check out allvoices.com/adtech for more of Allvoices' ad:tech coverage. This series is supported by ad:tech.


text:
National Alliance on Mental Illness
page printed from http://www2.nami.org/
(800) 950-NAMI; firstname.lastname@example.com
December 22, 2006
Help for the Holidays
New brochure offers tips for persons with mental illnesses, their families and friends, and their faith communities
Christmas, Hanukkah, Rohatsu, Eid ul Adha, Kwanzaa, Solstice, and Yule are all holidays this time of year when families come together to celebrate and reminisce. This can be an especially hard time for some people, though, who may be coping with grief, loneliness, illness, economic concerns, or relationship issues.
If you are dealing with any of these things, you are not alone.
Recognizing that people's experiences are often quite different from the "Hallmark" images that bombard us during this time of year, Rev. Susan Gregg-Shroeder of Mental Health Ministries has created a brochure called "Mental Illness: Coping with the Holidays." In it, she offers tips for persons with a mental illness, their families and friends, and guidelines for faith communities.
"Despite our good intentions, remember that the holidays rarely turn out as planned," writes Rev. Gregg-Shroeder. "As a person who lives with a mental illness, I have learned the importance of self-care…especially during times of stress in our lives.
"Try as much as possible to maintain your routines like sleeping, regular meals, exercising, taking medication, keeping appointments with mental health professionals and attending support groups," she advises.
She also provides advice for families and friends of people with mental illness, and their faith communities, such as how to reach out while respecting others' boundaries and limitations.
Download the brochure now from www.MentalHealthMinistries.net.
Like Mental Health Ministries, NAMI's FaithNet also provides resources to support faith communities in mental illness outreach, education, and advocacy.
FaithNet is a network composed of members and friends of NAMI. It was established to facilitate the development within the faith community of a non-threatening, supportive environment for those with serious mental illness and their families, pointing out the value of one's spirituality in the recovery process from mental illness and the need for spiritual strength for those who are caretakers.
FaithNet is not a religious network, but rather an outreach to all religious organizations. Its success can be attributed to the basic tenets of all the major religions-- giving care and showing compassion to those in need-–something that is especially important this time of year.
Visit the FaithNet Web site at faithnet.nami.org.
Happy holidays from everyone at NAMI, and best wishes for a healthy, prosperous new year.


text:
|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
The Variety entertainment news source reports that Warner Brothers and Leonardo DiCaprio's Appian Way production company have acquired the live-action adaptation rights for Yoshiaki Kawajiri's Ninja Scroll action anime film from the Madhouse anime studio. Kawajiri wrote this tale about a wandering ninja fighting a conspiracy of demons, and he also directed the original anime with ultraviolent yet fluid animation. Alex Tse (Watchmen, The Illustrated Man) is slated to write the live-action version, but DiCaprio himself is not planning on acting in the film. Appian Way's Jennifer Davisson Killoran and Mike Ireland will produce with Madhouse itself. Warner and Appian Way have already acquired the rights to produce two live-action films based on Katsuhiro Otomo's Akira manga. Killoran is also planning to produce the Akira project as well. Manga Entertainment released the original 1993 Ninja Scroll anime film in North America, while Urban Vision helped produce and later released the 2003 television series adapation. The American publisher WildStorm created its comic book take on the story in 2006. Madhouse revealed at Anime Expo 2008 that it was still planning a sequel to the original anime film.
Thats really cool! =D A Live-Action Ninja Scroll!??!! I cant wait! (=D
???????? are you not certain you would like to see it too? Or maybe you mean !!!!!!!!!! LOL?
"Me?... Evil?...Never"~ Hell UserOtaku God
Our posts are going to get deleted again! >.<
"Me?... Evil?...Never"~ Hell UserOtaku God
The flames of hell burn white with indignation and dance to the rhythm of this chaotic revalation of information about the sequel to the ninja scroll animation.... The path to conquest leaves nothing else to be desired!!!!
that might be interesting to watch, ninja scroll was an awesome anime and unlike some of the anime films slated for a live action release this is probably the most doable. "You know what you have to admire? A Catholic hit man who blesses himself just before he strangles someone."-George Carlin
i wanna see this, i own the movie (my free dvd via manga) and i want to see the series. i'm gonna go rent it at blockbuster. "When the heavens do not bring forth justice, man must bring it upon himself to do so. That is the meaning of Jinchuu." -Enishi Yukishiro.
ah now that would be cool


text:
NSCLC is "Major Battlefield" as Merck,...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
PCR is a workhorse of biotech—whether it's being used to prepare samples for another assay, or to assay samples from another preparation. From the search for point mutations to discovery of methylated DNA biomarkers, homebrew tests can be crafted to fill in where off-the-shelf kits fall short.
Real-time (q)PCR gives quantitative readings while end-point PCR affords digital answers, which can themselves be quantitative. Researchers at Select Sciences' "qPCR Europe Conference", held in Munich last month, powwowed about what uses they put it to in their search for more reliable, sensitive, automatable, and innovative diagnostics.
Ready-to-use kits are available for PCR-based diagnosis of many, if not most, of the viral infections that routinely find their way into the clinic. Yet when it comes to highly pathogenic viruses like pox viruses—which, because they can quickly kill off their hosts, tend to be far less common—"there's definitely no market," noted Andreas Nitsche, Ph.D., of the Center for Biological Safety 1 at the Robert Koch Institute in Berlin.
To identify such pathogens "you first need your own assays—your own assay design, your own controls, your own procedures how to establish such an assay," he explained. "It's not like a routine clinical lab." The generic infectious agent needs to be found, and then the species or variant identified. For this, the pox expert says, bioinformatics plays an increasingly important role.
Viruses like the pox viruses have a very conserved genome, and their sequences can be compared by eye or with standard software tools. But in cases involving more heterogeneous viruses like the flaviviruses, dengue, or yellow fever, "we are talking about many, many thousands of sequences, and you have new sequence entries in GenBank almost every week," he pointed out.
Assays need to be checked to make sure they're still valid for all the known variants. And aligning and comparing thousands of sequences can take weeks or months. Dr. Nitsche is currently testing a plug-in for commercial software—to be released soon—that promises to streamline the process by providing automatic tools for sequence control and theoretical validation of assays.
Even identifying a particular virus type—for example, that the etiological agent of SARS is a coronavirus—can also be a challenge. This had been done with electron microscopy (EM), which is "the perfect open-view tool—you see everything that is in the sample," Dr. Nitsche said.
But EM has its limitations: it will only identify the family of pathogen (it can't discriminate between smallpox and vaccinia, for example), and it requires a relatively large pathogen concentration (in the range of 105-6) that may not be found in blood or other infected body parts.
Dr. Nitsche and other virus hunters have been exploiting techniques such as generic PCR—using generic primers that will amplify everything in the sample—as well as deep sequencing to find sequences that may not have been known before. Then, "you have a real need for bioinformatics because you have to handle a ton of data."
At present, a qualitative nucleic acid-based test is all that is needed to diagnose the presence of a pathogen, said Philip Day, Ph.D., reader in quantitative analytical genomics at Manchester University—it's there or it's not. But when looking for biomarkers for cancers and the like, on the other hand, it's important to get a measure of how much is there, and on how many cells.
Yet these tests fail to take heterogeneity into account. "They tend to involve 'bulk analysis', whereby one starts off with these tissues with lovely architecture and structure, and then we jump in and lyse these tissues for a supernatant of nucleic acids, from which we try and ascertain some sort of diagnostic value via qPCR," Dr. Day said.
qPCR is avidly good at picking up an aberration such as a tumor marker in a biopsy or blood sample. The problem is that it's very hard to know the number of cells actually carrying the aberration and the distribution of aberrations across the cancer population. In addition, qPCR can be impeded if the target nucleic acids are too heavily diluted by other, nontarget nucleic acids.
As diagnosis and therapy move closer to the goal of personalized medicine, risk groups need to be more precisely defined by more subtle measurements of biomarkers. Dr. Day is aiming toward single-cell analyses, calculating answers in numbers of molecules per cell. For now that means employing homogeneous extractions commencing with FACS to sort individual cells into 96-well plates for qPCR.
Ultimately he hopes to be able to do the same thing using a high-throughput, continuous flow microfluidics system with integrated two-phase PCR and fluorescent detection. Since this is the result of a single cell, it's not always necessary to use real-time optics, Dr. Day explained.
Yet the emphasis on single cells puts him in a strange predicament: data from a single cell isn't necessarily indicative of the disease or tissue, Dr. Day confessed.
"So therefore what we're doing presently is trying to ramp up the numbers of individual cells that we're analyzing, to identify what is the minimum number of single cells we need to analyze by amplification, which will give us a full portrayal of the population of cells." This, in turn, will be used to colonize databases to make full sense of the single-cell information in the context of disease progression and treatment.
Biomarkers are often about more than just how the As, Gs, Ts, and Cs line up. Much work of late has concentrated on epigenetic DNA modifications such as methylation of CpG dinucleotides, which can have profound implications for the expression of tumor suppressors and other genes.
Frequently the search for methylated DNA starts with bisulfite conversion of unmethylated cytosines to uracils (leaving methylated cytosines untouched), after which a variety of techniques involving standard or methylation-specific PCR (MSP) can be used. Collectively these are considered bisulfite sequencing.
Andreas Weinhäusel, Ph.D., senior scientist at the Austrian Institute of Technology, was using bisulfite deamination-based MSP to look for differentially methylated genes in leukemia. The conversion process itself fragments and degrades the DNA, and so there is a tradeoff between the specificity that results from higher stringency and longer incubation times, and the sensitivity of detecting unmethylated vs. methylated DNA found under less stringent conditions.
What the proper balance is "changes also from gene to gene," he noted, making it less than ideal for the genome-wide screening and validation of already identified markers he was undertaking.
Dr. Weinhäusel decided to return to the "more or less forgotten" technique of using methylation-sensitive restriction enzymes (MSREs) in place of bisulfite conversion as a precursor to qPCR to examine the methylation status of genetic sequences. "Everybody used restriction enzymes over the last 30–40 years," he said.
The number and quality of the enzymes and the conditions for handling them have improved, making him predict that they "might have some sort of renaissance in qPCR and methylation testing." MSRE-qPCR validated markers from their own studies on lung cancer were confirmed by bisulfite-pyrosequencing resulting in almost perfect classification of tumors and normal tissues by both methods.
There are several other advantages of MSRE-based analysis over bisulfite-based approaches, he noted. It's easier to design PCR primers for native than for converted DNA; multiplexing and parallel analyses are simpler; less template is required; sequence information can be lost with bisulfite conversion; and because there is no deamination, no purification is required—and fewer steps means less chance of introducing bias.
There may be an issue in designing PCR conditions for native DNA from CpG islands, such as Fragile X syndrome's ccg repeat and other C-rich repeat expansion diseases: the very high CG content means the DNA melts at higher temperatures—often as high as 95–100°C. "In that situation I think it is really useful to have the bisulfite conversion because here you are dramatically reducing the Tm of that target region," he explained.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Closed Captioned
Learn exposure, focus and creative techniques for photographing flowers in spectacular detail. Join top photographer and bestselling author Harold Davis to explore the many facets of successful macro photography, starting with expert tips on composition. Delve into extension tubes and filters for an affordable way to master extreme close-ups, and navigate challenging lighting with ISO, aperture and shutter speed. Cultivate your artistic vision using selective focus, unexpected angles and depth of field to create imaginative, Impressionist-inspired shots. Plus, learn how to execute an indoor shoot and present your photos in a strikingly unique portfolio.
Get inspired as Harold Davis shows you some of his beautiful floral work and talks about the goals of this interactive video class.
Harold gives you a look inside his gear bag and talks about choosing cameras, lenses and tripods. Learn how exposure and shutter mode settings affect your image.
Get up close and personal with your floral subjects. Learn how to use extension tubes and close-up filters, and how image stabilization works.
Learn the nuances of focus at close range. You'll discover how to set aperture and depth of field to achieve your desired images.
Harold shares professional secrets that elevate floral photos to the extraordinary: unusual angles, selective focus, in-camera multiple exposures, deliberate under- and overexposure, and more.
Move into the studio and evaluate your impressionistic flower photos and other artistic experiments with an artist's eye.
Enjoy flower photography all year long. Set up and light your studio, learn to choose and handle flowers, and create stunning images of individual blooms and full arrangements.
"Whether you're a photography newbie or an old hand at photographing flowers, this course is for you. It is an easy to understand course with lots of simple-to-incorporate techniques. I sat through the whole course at one time. it took nearly four hours as I kept rerunning parts of the video and stopping to take notes. I have a pocket full of little gems that i know will make a difference in my flower photography as well as my overall photography."
- Gail Berreman


text:
Source: Apple
quote: Just like Windows vs Mac, when 75%+ of the people are using something (Android) it's going to have more infections. Oh the horror...
quote: We all know YOU love a closed system for many of the benefits, security being one of them, but that doesn't make you right.
quote: It also has better apps, smoother and faster UI performance, excellent screens and battery life, things like that. I'll take it over almost uniformly inferior hardware (Droid DNA is one of the few that stacks up), inferior apps, etc. It isn't for everyone but its fine for me, no reason to get mad.
quote: How did we even get on this? I'm pretty sure it wasn't from something I said.
quote: It means you have nothing else.


text:
Wednesday, September 16, 2009
A Tough Choice for MCA - Dogged or Tainted?
The same EGM will also decide on whether his sacked deputy Dr Chua Soi Lek will be able to return to the party. Indirectly, the EGM can be seen as an extended presidential election for MCA.
A vote of no-confidence against Ong and a support for the return of Chua can potentially put the latter in-charge of the party.
Chua is right to say that the Chinese community is no longer bothered with their tussle. There are many issues which both Chua and Ong did nothing to address e.g. the Teoh Beng Hock death, continuation of the NEP, reform of public institutions, racism in Utusan Malaysia and others.
Chua is evidently an old school leader who believes, like both Lim Keng Yaik & Koh Tsu Koon, that his party needs to use a soft and persuasive approach to deal with UMNO. This action over the years has contributed to the hegemony of UMNO in the coalition.
Chua should refrain from being a pot calling a kettle black. It is evident that his leadership of MCA (more than 30 years) did nothing to help this government to rule more justly. Take a poll now and many non-Malays will be able to tell him that they feel like 2nd class citizens in their mother land.
It is unbelievable that leaders of MCA and Gerakan continue to tolerate UMNO after the Ahmad Ismail, cow head, Utusan racist articles and others.
How different is Chua leadership? What can Chua do to help the Chinese?
The verdict of the March 2008 general election should serve as a good lesson to MCA. The people expect politicians to respect their constitutional rights. No point referring to the Rukun Negara everytime, like Tsu Koon, to point out to UMNO that they should observe respect. It is a cowardice act.
The people want an outspoken, courageous and decisive party to represent their interest. It is time for the MCA leadership to do two things - first, turn multiracial and second, clean up their image and lose the baggage.
Otherwise, Chua can steer his MCA to become more buddy buddy with an unrepentant UMNO and suffer a sorrow destruction in the next general election.
I have an advice for Chua - repent. He said in his interview with Malaysiakini:
Our readers are asking: In view of the sex scandal DVD, why are you fighting? Why didn't you retire after that?
Somebody taped me. I didn't tape myself. If I tape myself and it leaks out, I should go off. Nobody is talking about the person who taped me and why he taped me. Why? Are we going to have this political culture where we film their secret life, or trap them.
No, the problem is not because you did not tape your sexual exploit. You should go because you were caught on tape having an illicit sex with another woman who was not your wife. What can Chua expect the Chinese community to learn from his leadership if he cannot understand such a simple fact?
To Ong and his promise to investigate the PKFZ financial fiasco; a promise is a promise. The people especially the voters of Pandan will know what to do to you come the next general election if this promise is not being fulfilled.
My support for Ong is conditional. He wants the people to help him fight corruption, create a benchmark for managing public projects and to hold the government/contractors etc. accountable for their action.
Good. He got it (the support). Now, lets focus on the delivery. He should start by telling us how he can continue with his endeavour since the newly established Special Task Force does not include him.
Oh ya, please ask for my permission if MCA (under Chua) is going around claiming to represent the Chinese community.
I can live with an arrogant and aloof fellow who does his job well and handle my money responsibly. Who wants to have a MCA president as his karaoke buddy anyway? Maybe, except Tiong.
20 comments:
Chua is telling us we can go f**k around, and it is ok if it is not tape.
Adultery is standard operating procedure for his kind of leadership. Role model??????????
What kind of leadership he has? Please go lead other creatures and not human!!!
- francis said...
Well said,my sentiments exactly
i fully agree.
- wong said...
what he is saying he can fxxxk yr wife yr daughter yr sister its ok....as long u are dato , m c a deputy president ,..minister .that come with perks ...
A tainted "leader" is a useless leader who would be unable to perform his duties to the best of his abilities because of the baggage that he carries!
His mentality is obscene. If he thinks that just because he did not process and release the video tape, then, he is not guilty of his wayward behaviour,.....he is gonna be shock to learn that the public holds a person of his position to a certain standard of behaviour.
What he is claiming is similar to saying that a thief is not guilty of stealing even though caught red handed because he did not personally admit or reported that he was stealing. What stupid logic is that???
That's another reason why he should not be appointed to any responsible position because his illogical claims of innocence is not befitting of a person in any position of responsibility.
I always thought the chinese were smarter than the other races. But they have proven me wrong...How the fuck you guys can vote for a porn star? I just cant believe it. I think MIC is better off than you guys. You guys have really become stupid.....
- looes74 said...
You are sure that OTK's going to fulfill his promise. What a tangled web we weave. Reminds me of some the Yes Minister & Yes Prime Minister episodes.
As for Chua, I believe he's repented by resigning from all posts before last GE. It's the delegates who resuurect Chua's political's career.
Anyway, I would stay back & enjoy the brawl going on. Better still, accelerate the further demise of BN. Great!
I have only one word for Chua...You are a disgrace to the Chinese community. Supposedly you have won in the coming EGM, what does it prove?? Remember, you are tainted and so are the followers who follow you... all for their personal gain. For the Chinese community....fat hopes.
Stop the fight and get your goons to toe the line.
Chua is still putting his stick in places where it should not be!! He totally ignorant why MCA failed in the last erection.
- Bee Leong said...
MCA is doomed and need a major overhaul..
Please ask MCA to check their member, those with 'dato or tan sri' title.. There are few involve in gangsterism, illegal operation and so on..
Ask Dr. Chua, did he ever attend to a dinner organized by the gangsters in Batu Pahat?
Did Dr.Chua ever reported someone to the authority who he knows is dealing with the illegal business such as ah long or illegal gambling?
MCA doesn't represent all Chinese.. I hope they wake up.. Next going to fall is JOHOR!! so call their strong-hold..
not dat anybody fancy much abt OTK, but those MCA delegates who voted the porn actor back & now still support him are saying to orang cina that being unfaithful to one's wife is ok. time travelled back to old Cina days, CSL wud hv been punished by drowning in a pig-basket together with his lover ... wat makes him think dat he still be a community leader? oh ya, money politics learned from the old master UMOO ... his supporters are equally rotten! can't wait to annihilate MCA come GE13!
Chua should retire and not continue. I think that's the consensus but Superman is not superman either. Both should step down. Superman is not fit to be a leader, he has failed to explain the jet rides and show his personal account when challenged. He is free to make accusations behind closed doors and make police reports when stand accused. He has nothing in history as a leader who bridge goodwill and unity but a trouble maker even in 2003 when he behave like a hero taking on the incumbent. We don't need heroes in politics but leaders who positively contribute to the betterment of Malaysians. Do you see his 100 days in office dynamic? What reforms? What blueprint for transportation? Please wake up, Malaysians.
May be Chua thinks he is an electric pot calling the kettle black ?
All he wants is to be the President of MCA so that he can continue to be a porn star.
He still has provided me with just one, just one, name of a Chinese Director General of any ministry. Also what did he do to get a more senior portfolio ministry for the MCA after Tun Tan Siew Sin in the years when he was a minister ?
What a shame & disgrace if CHUA is voted back! If the Central Delegates are so 'stupid' & not able to differentiate right from wrong, time for MCA to really pack & go!
ONG can't do anything if CHUA is around- like LIM CHONG Yu v. TAN's GANG in the early part of MCA.
I still remember the famous phrase: the Chinese War in Malaysia is lost. To me, it is not just the Malaysian Chinese but the whole nation under BEEND.
Superman has two allegations he failed to explain. The first allegation related to millions of properties worth including shophouses, double-storey linked houses and semi-D bungalows. The second are the jet plane rides. Would you pay for RM8000 for a ride on emergency. What emergency? Did he explain and elaborate? If this thing was not brought up, where would he transfer the charges to? The third and worse allegation, collecting RM10 million for his campaign as president? Is he more morally clean than Chua? One is sex and the other is money. MCA is dead
Whoever is the president of MCA, he will not be supported by the Chinese electorate. Then we may ask, if that is the case, why are people fighting to be the MCA president? Well for a start, the president can preside over an organization with a multi billion ringgit asset base, and a media organization that can bring benefit to the president. Also, he gets to preside over the PKFZ thingy, where he will be courted by people who wants the whole thing to be covered up, and thus that seat of influence does bring some benefit. So I say to Ong TK, if all those bast&%$s out there are shitting on you for blowing open the PKFZ, I think you better bare all the dirty linen on PKFZ while you still have time to do it. Yes, exact your revenge NOW while you are still in that seat. AT least the rakyat will remember your good deeds on PKFZ if all those bast%$#s go to prison for stealing our money.
Rumor that the police has finally traced.........payoff.
forget about all these clowns just convince your friends and relatives to vote PKR in
If look at bigger picture Tun could be right.......the return could more 100 times.....do you guys a football fan? I am.........Real Madrid, during the President Perez, when he bought players like Zidance, David Beckham, Luis Figo...by paying huge money. All this players had give Real Madrid good money return.
During the tenure of this players, Real Madrid have not won and prestigious trophy…. In return this players has given Real Madrid good money……..from selling theirs shirt, advertising & etc...
Tony Fernandez is someone very special. Maybe the one and the only, before that AirAsia was under DRB –Hicom, no one know about this company. Now you mention AirAsia……….everybody knows is Low cost carrier.
He bought AirAsia for on RM1……How many people can do it? But you also need to have very good network in order to that…..he does got very good network…
If he able to bring Malaysia of specialty……..Just like you said AirAsia, we know is low cost carrier…
- looes74 said...
OMG! You know in Singapore, F1 racing is done in Shenton Way to boost up CBD areas. I mean more sales, hotel booking, makan & so on.
I am not sure spending plenty of money of having F1 in deserted area would help Malaysia to earn tourist income
It's more of a shabby trade
- justice4otk said...
Read more here in Justice for Ong Tee Keat . Here in http://justice4otk.blogspot.com/


text:
Meet hot gay men at matchmakers' East York personals. Our site has thousands of queer men, gay, bisexual, transgender and transsexual East York gay personals area. Same sex relationships and looking for men seeking East York men then create a free profile today, it's easy!
East YorkJoin Now Free!
East York | East York Girls | East York Men | East York Lesbians
Black Singles | Asian Singles | Latin Dating
Matchmaker is a free East York gay personals site for your local area. We have the hottest attractive and available East York gay men on the Internet from cute bad boys to sexy older gay men; our site has it all! If you are a single gay man in East York and are looking for gay friendship, casual encounters or a serious relationship, create your free profile today!


text:
Enjoy this article? You may also be interested in these related items from our partners
TRON Legacy Light
Cycle Paper Giclee Print
Walt Disney Records The Legacy
Collection: Pocahontas [2 CD]
Walt Disney Records The Legacy
Collection: Disneyland [3 CD]
Released a few days ago, exclusively through MTV, Walt Disney Studios has now offered us the following hi-res image of a sleek new Tron Legacy billboard ad featuring a yellow light cycle. This ad compliments the original blue version we first introduced you to last month.


text:
Omaha Steaks Coupons & Promo Codes
Most popular now: Up to 65% Off + Free Shipping on orders of $46+.
Latest offer: 65% Off Premium Package + 4 Free Burgers & Free Shipping.
Up to 65% Off + Free Shipping on orders of $46+
2 Free Steaks $59 or more + Free Shipping
Purchase one of our $19.99 specials, including Bacon Wrapped Filets and Bacon Wrapped Top Sirloins
Plus, save on select steaks and entrees.
Free Shipping on Select Combos, Plus 4 Free Burgers
65% Off Premium Package + 4 Free Burgers & Free Shipping
Up to 71% Off Variety of Grilling Favorites
Plus, order today and get 4 free burgers and 4 free gourmet franks
Up to 62% Off and Get 6 Free Burgers
Check Out Deal of the Day for Big Savings
Create Custom Combo starting at $59.99
Enter for a Chance to Win $1,000 worth of Free Omaha Steaks when you Sign Up for Emails
Check Out Gifts Under $50 and $100 for Big Savings
Save 20% Off All World Port Seafood
Save Up to 56% Off Perfectly Assembled World Port Seafood Combos
Sign Up for Omaha Steaks Emails and Receive Updates and Offers
Steaklover Rewards! Sign Up and Get 2x Points on Your 1st Order
Plus Members Earn Products and Dicounts everytime the Shop.
In-Store: 2 (10 oz.) Pulled Pork Artisan Flatbread Now Only $14.99
In-Store: 1 (18 oz. pkg.) Pub-Style Cod Now Only $9.99
In-Store: 4 (4.5 oz.) Chicken Fried Steaks Now Only $10.99
In-Store: 4 (3 oz.) Polynesian Pork Chops Now Only $9.99
In-Store: 4 (8 oz.) Precooked Prime Rib Slices Now Only $59.99
Get 4 Free Burgers + Free Shipping on Select Combos
45% off Sitewide + 1/2 Price Shipping
45% Off Sitewide + 1/2 Price Shipping
Limited time only.
How to use a Omaha Steaks coupon
Omaha Steaks has a great referral plan that awards you a $10 coupon each time a friend that you refer to the site makes their first purchase. There is no limit to the number of referrals you can make and you can combine the referral credits on a single order. Use those credits on items featured in Omaha Steaks' "Daily Deals", "Rockbottom Prices" and "Overstocks" sections to create some really awesome savings.
You can learn more about Omaha Steaks on Wikipedia and Wikidata.


text:
Irena Kennedy: From Russia with Love
- Posted: Aug 22, 2006 at 3:22PM
- 5 comments
Loading user information from Channel 9
Something went wrong getting user information from Channel 9
Loading user information from MSDN
Something went wrong getting user information from MSDN
Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
Oops, something didn't work.
footballism wrote:She is a girl, and she writes code, quite amazing indeed.
Lots of women from Eeastern Europe CAN actually write code, not to mention using a PC.
Just look at the topcoder website. Says it all.
Greetings from Eastern Bloc.
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


text:
City officials canceled the New Year's Eve fireworks after a shooting in Old Sacramento -- but set them off Tuesday morning, instead.
About 8:15 a.m., the fireworks lit up the sky over downtown Sacramento.
Due to safety reasons, the fireworks had to be detonated, officials said. There were certain dangers involved with keeping live explosives around.
Inside KCRA.com:
Police: 2 dead, 3 hurt during Old Sac bar shooting
Photos: New Year's Eve celebration turns deadly in Old Sacramento


text:
|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
I've started reading this manga and it is awesome!If you like blood,arms flying off, eye balls popping,brain exploding,head chopping and some *ahem* scenes, then i recommend this manga!
I've actually never heard of this manga. What exactly is it about?"Bust through the heveans with your Drill!
what is it"I will be the GOD of this New World"
Battle Royale takes place in an alternate timeline - Japan is a police state, known as the Republic of Greater East Asia. Under the guise of a "study trip," a group of students from Shiroiwa Junior High School in the fictional town of Shiroiwa are gassed on a bus. They awaken in the Okishima Island School on Okishima, an isolated, evacuated island southwest of Shodoshima, also in Kagawa Prefecture. They learn that they have been placed in an event called The Program, also known as Battle Royale. Officially a military research project, The Program is a means of terrorising the population, of creating such paranoia as to make organised insurgency impossible. According to the rules, every year since 1947, fifty 3rd year junior high school (14-15 years old) classes are isolated, and the students required to fight to the death until one remains. Their movements are restricted by metal collars around their necks which contain tracking and listening devices; if any student should attempt to escape The Program, or enter declared "danger zones", a bomb will be detonated in the collar, killing the wearer. If no student dies in any 24 hour period, all collars will be detonated simultaneously.
After being briefed about The Program, the students are issued survival packs which include a map, compass, flashlight, food and water, and a random weapon or item, which may be anything from a gun to a paper fan.
Let the killing begin =D
It sounds really good! I might check it out! ^^"Bust through the heveans with your Drill!
"In A Girls Life We Like To Shop, Well I Dont!!"
So what chapter are you guys currently on?
"Bust through the heveans with your Drill!&qu
Hey Zaborg, what do you think of chapter 1?like the gore so far?
LOL! Yeah! I got to chapter 3 and I love it! I might decide to buy it later on! (I have alot of Manga I need to get first to catch up on... BADLY!!!) My computer is acting up or I would have read more!
haha, excellent.It gets really good when they all leave the classroom :DThe main character's best buddy..*sigh* R.I.P!
Read Too So I Hope Its Soon( Ill Let You Know Soon =})"In A Girls Life We Like To Shop, Well I Dont!!"
"Burn Baby Burn!!!"
same here sounds awesome
do u know why there is two types of spines of this manga


text:
WPU Singers Spring Show
Kenan Auditorium
Thu Mar 27th, 2014
07:30 p.m. - 09:30 p.m.
A Spring Fling Concert
William Peace University is delighted to announce the William Peace University Singers 3rd Annual Spring Concert in Kenan Hall at 7:30 p.m.
The William Peace University Singers are the university's glee club and ambassadors of goodwill in the Triangle Community.
Formed in the fall of 2011, the Singers have performed throughout the Triangle and beyond for regional retirement communities, such as Magnolia Glen, Springmore Retirement Community, and Waverly Place. They have mesmerized audiences for the Greater Raleigh Chamber of Commerce, the Fifty Group, Wake County's First Responder's Breakfast, the Jackie Ammon's Memorial Tournament, the Durham Bulls, the Raleigh Christmas Parade, the North Carolina Governor's Inaugural Ball, the Heritage Calendar Gala, A benefit concert for the Byer Family (Oakwood), Winterfest, Treyburn Country Club, LaFayette Village, the Raleigh Rotary Club, the Fourth Annual LGBT Center of Raleigh's Awards Banquet and more.
They have also traveled throughout North Carolina and Virginia to perform at regional churches and organizations.
Each year, the Singers perform a variety of music that cover multiple genres and decades. Get your tickets early for this show-stopping event because we always sell out early!
Event Time: 7:30 p.m.
Event Location: Kenan Hall
Tickets: $10 Adults / $5 Students (Note: a 6.75% entertainment tax is included in the ticket price.)


text:
Top Definition
Pug Wood is a timber derived from the Pug Tree which has it's native roots deep in India's forest region. Pug Wood is short but incredibly stiff when 'aroused' by female counterparts. Women love being fed Pug Wood on a regular basis due to it's addictive taste and feeling of bliss it gives them afterwards. Therefore there are many repeat offenders who frequent being fed the Pug Wood once they have had the taste. Pug Wood also goes by a few other names including the Mistry-Willow and Raj Hardwood.
"Is she hungry? Feed her the Pug Wood'
de Vixi-son 27 août 2012
Trending Now
Can you define these popular missing words?


text:
0 Members and 1 Guest are viewing this topic.
Looks very close to Nachtmann Rom cut. They also have a similar shape vase in their range. Source 1970's catalogue.
Darlyn, may we also have a view of the base, please?Brockwitz IMPERAT (since 1915) comes to my mind...Thank you!
Page created in 1.127 seconds with 39 queries.


text:
COLUMBIA — After years of having their efforts turned aside by state House Republicans, Democrats in South Carolina this year now appear to have more support for early voting from the GOP than at any time in recent memory.
But despite Republican support for early voting proposals in both chambers of the General Assembly, the issue remains a political flash point.
According to the National Conference of State Legislatures, 32 states and the District of Columbia have no-excuse early voting, which allows voters to cast ballots without providing an excuse during a designated period before Election Day.
South Carolina does not have early voting. It's one of 15 states that allows voters to cast absentee ballots so long as they can provide one of nearly 20 excuses laid out in state law, such as having to work on Election Day or being 65 or older.
In the Palmetto State, participation in absentee voting has increased dramatically in recent presidential elections. So much so, in fact, that the State Election Commission now believes that the lack of no-excuse early voting has almost certainly led many voters to lie about an excuse — a crime punishable by up to three years in prison — in order to be able to vote early anyway.
The state's absentee voting process is now used as "de facto early voting," the commission's spokesman, Chris Whitmire, has said.
Republicans have long opposed early voting in South Carolina.
Generally, residents from counties favoring Democratic candidates vote absentee in greater numbers than residents in Republican-backing counties (voters do not register by party in South Carolina, so breaking down absentee vote totals is an inexact science).
After years of failure, Democrats could finally win enough support this year from Republicans to bring true early voting to South Carolina.
But the conditions House Republicans could place on such a change may cause Democrats to balk, killing early voting for another year.
The Senate, which on some issues such as early voting has a working coalition of moderate Republicans and Democrats, has passed early voting bills in previous years. But the proposals have died in the House.
This year, a perhaps unlikely candidate has introduced an early voting bill in the lower chamber.
The sponsor, Myrtle Beach Republican Rep. Alan Clemmons, was one of the leading architects of the state's Republican-backed voter-identification law passed by the Legislature in 2011.
Clemmons, who heads the House election laws subcommittee, said he's fulfilling a promise he made during the debate over the voter ID law to consider supporting early voting.
He said that's despite his belief that people should vote on Election Day.
"The further we get away from our Election Day, the further we're getting away from what our founding fathers intended," Clemmons said.
Clemmons also said S.C. Democrats use the current 30-day absentee voting period for "organizational gain" and getting their voters to the polls.
He has proposed allowing early voting periods that begin 10 days before an election and end three days prior to the contest.
Clemmons' bill would eliminate in-person absentee voting, which has favored Democrats, raise the age for qualification for absentee voting from 65 to 72 and eliminate straight-party ticket voting.
Straight-ticket voting has slightly favored Democrats in recent elections. Clemmons said he proposes eliminating the practice because legal counsel has suggested the state must nix straight-ticket voting to deal with ballot design issues. Clemmons said during a hearing last week that House staff are continuing to study the issue.
Denmark Democratic Rep. Bakari Sellers sits on the House election laws panel with Clemmons.
He said Clemmons' bill is convoluted and "another attempt to limit access to the polls under the guise of early voting."
Sellers said he takes issue with the proposals to restrict absentee voting and raise the age to qualify for it, as well as the proposed elimination of straight-ticket voting.
"At what point does government stop its intrusion? I think that's unjust," he said.
Sellers said he doesn't see the bill passing in its current form.
In the Senate, every Democratic member is sponsoring a measure that would create early voting starting 11 days before an election and ending three days prior to the election. The measure would leave straight-ticket voting and current absentee voting procedures in place.
But the bill is stuck, despite clearing a GOP-controlled committee by an 18 to 2 margin. Republicans have placed a legislative block on the proposal, saying they want Democrats to first allow a vote on a so-called "nullification" bill. The nullification proposal by Beaufort GOP Sen. Tom Davis would bar state employees from enforcing the federal National Defense Authorization Act in the detainment of any U.S. citizen.
Democrats are blocking the proposal, saying they want a vote on their early voting bill first.
Columbia Democratic Sen. John Scott, a long-time backer of early voting, said he's confident the Senate will resolve the impasse.


text:
Enjoy this article? You may also be interested in these related items from our partners
Tomorrowland Frank
Walker Pop! Vinyl Figure
Funko POP Disney:
Tomorrowland - Frank Walker Action Figure
Tomorrowland David
Nix Pop! Vinyl Figure
With Brad Bird's Tomorrowland (May 22, 2015) in theaters — well — tomorrow, Walt Disney Studios has provided us with a round of its traditional 'fun facts' to provide some fun insight into the production of the film, which you can find below.


text:
Big plays carry day for Lions
MADISON, Wis. - Penn State had only 13 first downs to Wisconsin's 27, and the Nittany Lions ran just 58 offensive plays to the Badgers' 85.
Anyone who would have guessed those numbers before the game probably would have figured Wisconsin had not only won, but perhaps even come close to covering the 24-point spread. In this case, it's proof that stats sometimes lie as the Lions used several big plays to score or eat up big chunks of yards.
"A big part of our offense is taking shots downfield," said tight end Adam Breneman, who had a 68-yard catch and run for a TD on the fourth play of the game for a quick 7-0 lead.
Christian Hackenberg found Geno Lewis on a 59-yard TD pass for a 31-14 lead early in the fourth quarter. Allen Robinson took a short pass and juked his way to a 52-yard gain in the first quarter, leading to a blocked field goal. And on a play that helped preserve the win, Zach Zwinak broke free for a 62-yard gain in the closing minutes to help the Lions eat up more clock.
Those four plays were all the longest Wisconsin has allowed all season.
"You've got to hit the ones that are there," Hackenberg said of deep throws. "You're going to have a couple that are really close contended and the receivers get off and make great catches. But when we have them, we have to hit them, and we did tonight."
Coach Bill O'Brien said if the team tries to throw 10 deep passes that converting three or four is a good percentage, like batting .400 in baseball. He thought watching film on Wisconsin that the offense could have success throwing deep.
"We froze them a little bit at the line of scrimmage to see what they were in and then tried to, if they're playing cover one, try to get the ball to Allen or Geno down the field," O'Brien said.
Tight ends come up big again
Breneman and James caught three passes apiece and Kyle Carter one, giving the tight ends seven on the day. The unit finished with 60 catches for the season (James 25, Carter 18, Breneman 15, Matt Lehman two).
James said Breneman's late-season surge helped the entire tight end group become more of a factor. James also made one of the best catches of the season when he hauled in a 7-yard TD pass in the third quarter despite being blanketed in coverage.
Mistake-prone Badgers unimpressive
Wisconsin came in with the reputation of playing very good football on both sides of the ball, but it did neither Saturday. The Lions torched the Badgers' defense, and the home team had an uncharacteristically low 120 yards rushing.
"We didn't make enough plays on third down," said running back Melvin Gordon, who had 91 yards on 13 carries. "I thought we ran the ball well, I thought we ran hard. We just couldn't convert on third downs to stay on the field to keep it going."
The Badgers surprisingly didn't commit to the run as much as usual. Gordon averaged 7.0 yards per carry, and James White averaged 4.3 (56 yards on 13 carries). But the fact that both of them combined for only 26 carries shows how much Wisconsin got away from the run, and while some of that was necessitated by falling way behind, that wasn't the case early.
"That's not really how we're built to operate," Stave said of all the passes.
Stave completed 29-of-53 passes for 339 yards - the same number as Hackenberg - but the Wisconsin quarterback was wildly inconsistent and missed numerous targets all night.
The Badgers finished with 459 yards of offense, 14 more first downs than PSU and ran 27 more plays.
"Just a herky-jerky day," Stave said. "Sometimes we were moving the ball, we were moving it smooth, getting it up and down the field. Other times, we're putting ourselves in tough situations, third-and-whatever."
Wisconsin's defense also struggled, giving up the big passing plays to PSU.
"They didn't really do anything," safety Nate Hammon said. "We just didn't play up to our potential."
Hairy situation in the locker room
Offensive linemen Adam Gress and Ty Howle made a deal Friday night with linebacker Glenn Carson that they would get their hair cut if Penn State won. Surely enough, Carson went for the scissors in the locker room.
"I would say that I lost about roughly 6 or 7 inches," Gress said of his long blond hair.
Gress took off his hat to reveal some of the cut, something Howle was unwilling to do. Linebacker Ben Kline originally came up with the idea.
How long had Gress been growing that hair?
"The hair that Glenn cut off has been to a bowl game," he said. "The last time I cut that was before the TicketCity Bowl, Christmas Eve 2011. So it's been a while, it's been two years. It was overdue anyway."
Offensive line jumps early, often
Penn State's offensive line was flagged eight times for false start, four by left tackle Donovan Smith. All five starting linemen were flagged at least once. Gress was called for it on an early fourth-and-1 situation at the Wisconsin 12, and O'Brien was going to go for it with PSU already leading, 7-0.
"It's not good," O'Brien said. "And we hadn't done that all year. I take responsibility for that. I coach the quarterback, the cadence, the whole thing, I run the offense. That was bad football."
Mad at the media
O'Brien took the media to task for buying into the 24-point line against his team.
"I don't know who makes those lines," the coach said. "I'm not allowed to talk about betting. But it seems like a lot of you guys [in the media] felt like that was the right line, and you're wrong."
The coach said he talks to the players about how to not take what the media says to heart.
"One thing that these guys understand is it doesn't matter what any of you think," O'Brien said. "With all due respect, you guys are great writers, I mean you guys are awesome. But it doesn't matter what you think relative to our football team. It doesn't matter one bit what you think. It matters what they think."
Even the Lions "Jump Around"
Penn State's players took part in the customary Camp Randall Stadium tradition of jumping up and down when the song "Jump Around" was played between the third and fourth quarters. It is one of the most recognized traditions in college football.
"When Jump Around came on and we started jumping around, that's when I knew that we were going to get this win," Carson said.
News and notes
Penn State's season captains were announced: G John Urschel, DT DaQuan Jones, LB Glenn Carson, C Ty Howle and FB Pat Zerbe. Penn State's defense held Wisconsin to 24 points despite playing without starting cornerback Adrian Amos (sprained foot) and starting safety Malcolm Willis (shoulder) for much of the game.
Compiled by Cory Giger


text:
You picked Chinese for lunch and you were nervous, checking your watch. Guessing where your class would be right now. I wanted you to play hookey and you wanted to go back to school. When we got home you were restless and worried about library books and so I signed you back in.
We drove down Chicago Street and whirlybirds fell from the trees like snow and there was a house with a sign advertising "UPSTAIRS BASEMENT" and I squinted and laughed in my head at the thought and then we saw it actually read upstairs bedroom.
You didn't ask but if you did I would tell you my favorite color is the sky today.


text:
The search for a missing Deltona family, who deputies say is dead, will continue Thursday morning in a heavily wooded area near the family's home.
No email address was supplied by
To complete your registration on this site, please supply an address.
Please confirm or modify the email address to which you will have subscription offers sent.
For a more personalized experience, please supply the following optional information.


text:
|Cake Decorating
Closed Captioned
Whether you want to add a single perfectly gilded rose or paint an entire three-tiered cake in shimmering lace, Lisa will help you gain confidence and mastery over the airbrush, a complex tool with numerous cake applications. Learn the importance of choosing the right equipment for the job before diving into spraying simple lines, dots, daggers and gradients. Then work your way up as you explore color usage and mediums like luster dust and cocoa butter while applying advanced techniques for airbrushing a cake.
Meet your instructor, Lisa Berczel, and learn about how to transform the surface of a cake into a work of art.
Lisa leads an in-depth discussion on the different components that make your airbrush work: pumps and compressors, sprayers, safety equipment and other accessories.
Learn about using and mixing color, developing control and how to create lines, spatters, solids and gradients.
Master using a stencil to create beautiful, multicolor designs and learn how to make your own stencils out of found objects, lace and other fabrics. Learn how to paint onto isomalt to create a gilded rose.
Learn to apply smooth, custom color to entire tiers as Lisa demonstrates techniques to make solid-colored, ombr� and candy-striped cakes. Then discover airbrushing with cocoa butter.
Use cocoa butter to paint accents and learn how to incorporate molds and stamps into your airbrushed designs.
Learn how to maintain your equipment as Lisa demonstrates how to change paint colors and how to clean your airbrush.
Lisa troubleshoots some of the most common problems: Color density, blurry designs, fading and more.
Don't let equipment problems get you down. Lisa will show you how to work through needle and cap issues, how to diagnose spray problems and fix your equipment so you can get back on track.
"I love Lisa's work and her detail and clarity as a teacher. I understand so much more watching and listening to Lisa than I have in a couple of years of trying to learn things on YouTube. I've experienced so many of the issues that were in this class and I am so thankful to have had Lisa explain them all away!�
- Millmika3
Palm Springs, CA


text:
Cloud Patterns
- 6 parts
This video series summarizes common patterns and proven practices in using Windows Azure Cloud Services. The series is designed to be a mini platform where valuable experiences and ideas from Windows Azure Cloud Services users (that means you!) can be shared among the community so that everybody can benefit from these past experiences when dealing with
similar problems or scenarios.
- In Order
- Recent
- Most Viewed
- Top Rated


text:
Aromatic Cleaning Products By Scentsy
Now you can make your countertops and dishes smell "Scentsy Clean" with our new aromatic cleaning products. Our customers are raving about the popular new aromatic cleaning products, called Scentsy Clean! If you love Scentsy's amazing scented wax, oils and other home fragrances, … Continue reading


text:
The Elite 220 bar feeder for Swiss-type lathes features two barstock magazine types with basic bar feeder configuration: a standard linear/gravity magazine for barstock ranging from 0.25" to 0.787" and a "walking beam" type for barstock ranging from 0.080" to 0.25". The bar feeder can be changed from one configuration to the other in less than 60 sec.
Featuring calibrated, round-section channels and mechanical synchronization with minimal inertia, the bar feeder ensures speeds of more than 20,000 rpm, and Swiss lathe acceleration ranging to 1.5 G with silent operation.


text:
National Alliance on Mental Illness
page printed from http://www2.nami.org/
(800) 950-NAMI; firstname.lastname@example.com
A Family's Journey with Schizophrenia
By Jessica Edwards, NAMI
In this real, honest and vivid story of a family's struggle with schizophrenia, author Randye Kaye shows the reader what it is like for a family to be in chaos due to mental illness. Struggling with the changes her son, Ben, undergoes a transformation from sweet child to troubled teenager to, eventually, an adult with schizophrenia. Kaye does an outstanding job of reflecting how mental illness can rule a family from a mother's perspective.
From dropping out of high school, to cross-country ventures, from one job to the next, the changes in Ben causes his mother to be worried, afraid, sad and angry all in one breath. From the confusion before Ben's diagnosis to the trial and error to find the right treatment, through the ups and downs along the rocky road to recovery, the reader is almost instantly involved in this struggle, and feeling the desperate fear and pain of the family. Kaye is torn as a mother between her desire to stay involved, and knowing when to let go.
In Ben Behind His Voices, Kaye enthralls you into her family's story of warning signs, chaos, incarceration, hospitalization, recovery and hope. This is the story of so many families who are affected by mental illness.
It is important to remember that while schizophrenia is a challenging disease; there is hope for normalcy and recovery. Ben and his amazing mother prove it in their story.
Recently I was able to talk with Randye Kaye about her book.
NAMI: Why did you decide to write Ben Behind His Voices?
Kaye: The story began with NAMI, in a way. My son is now 30. I was a radio personality when these symptoms began to occur, and NAMI really changed my perspective. This book is a love letter to NAMI. One of my main reasons was to increase awareness of NAMI, and one of the best ways to do that is through a story. Because NAMI was so instrumental in becoming educated enough, I wanted to let more people know abut he hope and education NAMI can provide; and how education can empower a family to help their loved one, rather than giving up. Whoever I get the chance to speak to; I always say the most important letters after my name are 'MRG', Mother who Refused to Give Up. Because of NAMI, I found the courage and knowledge to help my son.
NAMI Family-to-Family was my favorite part of NAMI. It gave me support, and something concrete I could use—education without judgment. I quickly became a teacher, and then a trainer of teachers.
The reasons for writing it were always there, but finding time was another issue. And actually finding that time was a gift from the universe, in the six-month severance period following my last day at the radio station. I wanted to spread the message of hope and support further than just the people I met through NAMI. I wanted to help health care professions to see things from the family point of view. If the family is educated and empowered, they can be such a powerful ally in recovery. But if not, those families can just give up, or become detrimental to the process because they don't know how to help.
Every patient or client or case, is a person, who is someone's son, daughter, spouse, parent, brother, sister, friend; someone who is loved, who has a past— and hopefully a future. I named the book Ben Behind His Voices because I wanted to be clear that this is a person who had a bad stroke of luck because he has an illness. I wanted to spread empathy, offer hope, increase understanding and help others to not feel so alone.
NAMI: Did you worry about the impact sharing your story would have on your family?
Kaye: I really did. It was a risk, but it's always a risk because no matter how much we tell ourselves that it isn't our fault and we should be able to be as open about this as other people are about an illness like cancer, I felt that by jumping over that hurdle and being open, we could do some good.
The first person's permission I had to get was my son's. He is inching towards some sort of acceptance with his illness, and to respect his journey I always try to partner with him. I told him I couldn't tell his story, but I am telling the story from my point of view as a mother. He agreed to let me do that, and asked that I change his name for privacy purposes, which I did. He actually chose the name Ben himself, and also gave me permission to use his poetry and some of his writings.
My son is a sensitive soul, and he doesn't lash out, so I try to keep a mother's eye on his feelings. When the books came from the publisher, I knew that this would finally seem real, and watched for his reaction. He just smiled and said, "cool mom." Two days before the book launch Ben said he wanted to come to the event; that he wanted to "support me." This was a surprise, but of course I was delighted that he wanted to be there—but I was also a bit wary.
The book launch was a reception and book-reading, so I asked Ben how he felt about that. I chose passages carefully, since he was in the audience and had never heard some of them before. He asked me to state a disclaimer that, "If Ben were here, he would want me to remind you (the audience) that he may have a different version of this story; this is from the mothers point of view." This way, the people who didn't know him did not know he was there, and the people who do know him, already love him and know his story. This worked like a charm - and the evening went very well for us all!
NAMI: What advice would you give another parent in a similar situation?
Kaye: Find your NAMI Affiliate. If you don't resonate with your local affiliate, find another one that you do feel comfortable with. NAMI is a great place to turn for support and education. For professionals, hand out NAMI brochures to family members—keep them on hand in your office.
I also read memoirs; others' stories helped me so much.
Get as much education as you can. The more you know the better. An educated family is an empowered family. You will stop trying to fix things that can't yet be fixed; it will teach you patience. When you get support and education, it's easier to get to a place of acceptance. You have to build your way to acceptance.
Use communication skills. The most powerful thing I learned in NAMI Family-to-Family was how to talk to my son without making it worse. I learned to set limits, and I safeguarded those limits. Families can feel stripped of power, and you have to realize what you are and are not willing to do and tolerate. Change what you can, and not trying to change what you can't. Limits are part of self-care. Taking care of yourself and do what you need to do, so you are not feeling resentful when you are offering help to a loved one. Understanding my needs helps my son feel less resentful of needing my help. Understand that it isn't your loved ones fault.
NAMI: You discuss some really painful and difficult times in your story. What was the key thing that got you through those struggles?
Kaye: These two mantras helped me a tremendous amount. They remind me to stay grateful in the moment, and stay in a place of acceptance and hope: It is what it is, now what? and Whatever happens, we'll handle it somehow.
We all know recovery is like a game of Chutes and Ladders. It helped me to remember that you can't jump straight to acceptance, but eventually you must work from that place. Whenever there is a crisis or setback, I allow myself my own pain. I allowed myself to cry when I needed to cry, and allowed myself the process. And I allowed my family their process. Allow yourself the grief and pain.
I also read When Bad Things Happen to Good People. Somewhere deep inside I think maybe there is a reason for this, but I sure don't know what it is. So I don't look for the meaning.
But I do believe that bad stuff happens to good people, and I don't know why. No, it's not fair, and it's not my job to figure out why. But I have a journey and so does my son. But I know there is some plan, somewhere, that I have no access to, and Ben's life has a journey and I have to allow him that journey. However, he was thrown together with this family in this life so that we can be some support to him along his path, and vice versa.
A railing doesn't push, doesn't pull, it's just there when you need it.
There is a huge difference between hope, dreams and expectations.
Dreams are safe because you haven't taken any steps to prove them wrong. Hope is a little more concrete; you can take some action steps towards it, and you have seen the possibilities of hope. But you don't expect specific dreams, or you might feel your life is falling short somehow. Just dream, hope, and know you'll be okay no matter what. Expectation can lead to disappointment if you pin your happiness on whether or not certain things happen - but we can dram, we can hope, and in working towards those hopes we find our happiness, even if things come out not exactly as planned. Hopes must have some flexibility! We take steps to hope for the best, but also know we have the ability to handle whatever happens. I don't dwell on the negative—I am toward appreciation of the positive. I like to be in the present and be grateful to be here.
NAMI: Any final thoughts?
Kaye: Part of the effect I want the book to have, is I want to put one human face behind the symptoms of mental illness, in the hope that professionals realize, that every person they come across is a person with a past, with strengths, and is a human being with an illness—and to treat the whole person.
We must continue to advocate for early detection, better research, and fair media coverage for people living with mental illness. Services cannot be cut; we must fund them, make them available, improve them—so that people with mental illness can reclaim their futures, not be lost in a system that too often puts them out on the streets, or in jail.
I advocate for increased research and treatment, for strength-based support, for stomping out stigma, for insurance party, for more railings in the stairwell. I advocate for my son Ben, and for others like him. I advocate for possibility and support, not limitation and hopelessness. See the worth!


text:
Graham McIlvaine Named to National Award Watch List
MUNCIE, Ind. - Senior men's volleyball setter Graham McIlvaine was selected to the inaugural Lloy Ball Award watch list which will honor the nation's best setter. McIlvaine is one of sixteen men's volleyball player selected to the watch list for the award named after IPFW All-American setter and four-time U.S. Olympian Lloy Ball.
McIlvaine saw action in 25 matches last season and 74 of a possible 96 sets. He ended the season ranked 18th nationally with his 9.62 assists per set average and 21st nationally with his 2.18 digs per set average. McIlvaine tallied a season-high 51 assists at NJIT last season (Jan. 18) and got under a career-high 18 digs versus Limestone (Mar. 29). The setter recorded five double doubles on the year.
The Hinsdale, Ill., native sets in eighth in Ball State history in career assists with 1,999 sets. He is 155 sets away from passing Dave Carlson for seventh place. McIlvaine's 9.56 career assists per game average is eighth in Ball State history.
McIlvaine and the Cardinals will begin the season on Saturday, Jan. 4 when they host the two-time defending national champions UC Irvine at John E. Worthen Arena. First serve is set for 7:30 p.m.