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As Immunotherapy Revolutionizes the Cancer Treatment...
Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
Quadruple Helices Appear To Have Role...
Life Technologies inked separate collaborations with CollabRx and Ingenuity Systems that will integrate the two firms' analytics platforms with Life's products. The deal with Ingenuity means clinicians will be able to access the latter's analysis software through a dedicated portal for use in interpreting the results from Life's molecular diagnostic tests. The agreement with CollabRx will focus on developing and commercializing the firm's cloud-based genomics analysis and content resources for use in conjunction with Life's cancer diagnostics pipeline and laboratory-developed test services business.
CollabRx' medical and scientific content is organized in knowledgebases that express the relationship between genetic profiles, other aspects of the patient's disease, such as stage and prior treatments, and potential therapeutic avenues, including molecular diagnostics, clinical trials, and drugs relevant to treatment planning. At the heart of these knowledgebases are Molecular Disease Models (MDMs) that incorporate the latest genomic data.
Life will use the CollabRx technology and content to marry the results of its own broad molecular profiling panels with associated data on trials, drugs, biologics and other data relevant to cancer treatment planning. "It's critical to contextualize the results of complex cancer panels to make them useful for physicians," comments Ronnie Andrews, Life's president of medical sciences. "CollabRx has pioneered the development of a scalable platform and process to provide actionable, accessible, and credible knowledge at the point of care to aid physicians in developing a cancer treatment plan based on tumor molecular profiles."
Ingenuity's analysis solutions are all founded on the firm's Ingenuity Knowledge Base repository of biological interactions and functional annotations, generated from individually modelled relationships between proteins, genes, complexes, cells, tissues, metabolites, drugs, and diseases. The collaboration with Life will provide the software and content to physicians, in context with other software and database solutions, to provide information that could aid in treatment decision-making based on the biological basis of the individual's disease. Given Life's recent launch of the Pervenio™ Lung RS gene expression test for lung cancer risk stratification, the Ingenuity solution will initially be made available for the latter's emerging line of cancer diagnostic tests.
"Advanced diagnostic tests like the ones we are developing at Life Technologies will deliver increasingly complex information about a patient's disease," Andrews adds. "It is essential that those results be made relevant to interpreting physicians by making all possible contextual information available in a single interpretation portal."
Life took a major step forward in its drive to build and expand a molecular diagnostics business, through the acquisition of Navigenics, and also Pinpoint Genomics in July. It was Pinpoint that had originally developed the recently launched Pervenio lung cancer test. Since then Life has in addition signed a companion diagnostic development deal with Bristol-Myers Squibb, and at the start of 2012 the firm teamed up with DaAn Gene to establish Life Technologies DaAn Diagnostics, a joint venture diagnostics business in China.
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$67.00$1.40 / ml
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Hyperpigmentation can be treated: Accumulated brown spots and uneven skin tone can age the appearance of your skin as much or more than fine lines and wrinkles around your eyes. As the body produces more melanin over time, these brown spots can intensify into severe discolorations. These are considered very difficult cosmetic concerns to resolve. The appearance of discolorations can be treated within a skin care regimen that includes effective ingredients and diligent use of sunscreens.
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For external use only. Do not use on irritated or broken skin. Stop use and ask a physician if rash, irritation or sensitivity develops and lasts. When using this product do not get into eyes. If contact occurs, rinse eyes thoroughly with water. Keep out of reach of children. In case of accidental ingestion, get medical help or contact a Poison Control Center right away.
|Active Ingredients: Avobenzone (2%), Ensulizole (0.9%), Octisalate (5%), Octocrylene (1.5%)
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Reviewed by 2 customers
No visible difference in dark spots
By TJlover
from Los Angeles, CA
describe yourself Budget Buyer
- Easy To Use
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Best Uses
- Sun Damage
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I bought this product in the hopes that it would lighten the acne scars I have developed over the years. While it is an effective moisturizer with sunscreen, perfect as a day lotion, I did not see any noticeable difference in the lightening of my dark spots and scars.
Bottom Line No, I would not recommend this to a friend
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- You may also flag this review
(1 of 1 customers found this review helpful)
Feels Great!
By AliCat
from Artesia, NM
describe yourself Budget Buyer
- Easy To Use
- Improves Skin Texture
Best Uses
- Oily/Combination Skin
Comments about DDF Protect and Correct UV Moisturizer SPF 15, 1.7 oz:
I purchased this product hoping it would help with the dark spots on my face from sun damage, but I have not seen any real noticeable differences. Then I compared the ingredients with some sunscreen in my medicine cabinet and the ingredients are almost identical. So basically, I overpaid for sunscreen. But it feels great on my skin and it absorbs quickly!
Bottom Line No, I would not recommend this to a friend
(1 of 1 customers found this review helpful)
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subset: commoncrawl


text:
Kerry Tobin wrote:Which ad?
Please note that the Leader simply uses Google Ads to fill in any open advertising space. If there is an ad you find offensive or don't feel is appropriate, send an email or post a link. If I can track it down and we agree, we can block it.
XYZ1 wrote:River Rat - it's called freedom of speech.
Just because you don't like it doesn't mean someone can't buy advertising space and use it to say what they want.
This isn't the case, but I could just as easily say I do not want any pro-gun groups advertising on the Leader.
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on July 13, 2013 - 10:21 AM
The head of the Erie County Democratic Party wants Kevin Gaughan to run for Erie County Comptroller.
"Most people in Erie County know Kevin Gaughan, and his record of independence and advocacy on behalf of hardworking taxpayers," Jeremy Zellner said today in a statement.
"Kevin has unquestionable integrity, and a deep commitment to our community. There could not be a better taxpayer watchdog than Kevin."
Gaughan said this afternoon that he would give the request great consideration but has not yet accepted the request.
"I'm honored that the Democratic Party has requested that I consider becoming a candidate for public office. And I feel that when Mr. Zellner and my party ask me to lend a hand, I am duty bound to give the request considerable thought," Gaughan said in a statement.
"I've always viewed the office of county comptroller as among our region's most vital and serious positions. It's the public office that perhaps most fits with my private sector efforts to reduce taxes, reform local government, and align our community with the future."
Gaughan said that he has been conducting a study on the cost of town and village governments and also trying to "complete a memoir that I've been struggling with for some time."
"So I don't know how my long-suffering editor is going to feel about my taking on an endeavor that may add several new chapters to my book.
Gaughan is a Buffalo attorney with extensive experience in corporate and municipal finance. He is a nationally-known expert on government reform, and leader of a movement to permit residents to decide the size and cost of local government.
"Voters across Erie County recognize Kevin and his efforts to give them a voice in their community," Zellner concluded. "Kevin's past work illustrates that no politician can tell him what to do and that level of independence is the exact sort of leadership that our community needs in a Comptroller."
Lynn M. Szalkowski, previously back by the Democratic leaders to run for comptroller, recently withdrew from the race due to health reasons.
Gaughan is a graduate of Harvard University, Georgetown University Law School, and he studied public finance at the London School of Economics.
He is the author of "At First Light: Strengthening Buffalo Niagara in the New Century."


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Legislative Session proceedings
Welcome to the official site of Indiana State Senate District 25. State Senator Tim Lanane represents the district in the Indiana General Assembly. Senate District 25 includes the City of Muncie and the southeastern portion of the City of Anderson. District 25 also includes Union Township and part of Anderson Township in Madison County and Salem, Center, Monroe, Liberty and Perry Townships, all of which are in Delaware County.
Nov. 19, 2013: The 118th General Assembly convenes for Organization Day.
Jan. 6, 2014: The 2014 legislative session begins.
Jan. 10, 2014: Bill filing deadline for the 2014 session.
Mar. 14, 2014: Sine Die. The 2014 session ends.


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Women PeaceMakers
Institute for Peace and Justice
Contact: Jennifer Freeman
Phone: (619) 260-7569
Fax: (619) 260-7570
Location: KIPJ Room 121
Joan B. Kroc School of Peace Studies
5998 Alcala Park
San Diego, CA 92110
Joan B. Kroc Institute for Peace and Justice
Women PeaceMakers Documentary Films
The Women PeaceMakers Documentary Film Series captures the work of Women PeaceMakers around the world. The series documents best practices and traces personal stories of peacemaking, courage, and hope.
The documentary series is produced in conjunction with Sun & Moon Vision Productions.
Documentary Shorts
- Palwasha Kakar of Afghanistan
- Claudette Werleigh of Haiti
- Manjula Pradeep of India
- Rashad Zaydan of Iraq
- Sarah Akoru Lochodo of Kenya
- Wahu Kaara of Kenya
- Shukrije Gashi of Kosovo
- Vaiba Kebeh Flomo of Liberia
- Milet Mendoza of the Philippines
- Svetlana Kijevcanin of Serbia
- Rebecca Joshua Okwaci of South Sudan
- Nora Chengeto Tapiwa of Zimbabwe
Rhythms to Peace: The Way of a Woman Peacemaker
Chronicles the life of Susan Tenjoh-Okwen of Cameroon.
Total running time: 24 min.
Leading the Way to Peace
Features Luz Méndez of Guatemala, Zarina Salamat of Pakistan, Shreen Abdul Saroor of Sri Lanka and Christiana Thorpe of Sierra Leone.
Total running time: 65 min.
Download Study Guide [PDF]
Reversing the Ripples of War
Features Sister Pauline Acayo of Uganda, Mary Ann Arnado of the Philippines, Emmaculeta Chiseya of Zimbabwe and Thavory Huot of Cambodia.
Total running time: 22 min.


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i totally saw this coming theres just not space for guys like him with tatar,andersson and nyquist coming up ... i expect guys like miller and samuelsson not to be back next season ( well maybe not samuelsson cuz holland loves him )
what bugs me though is the dump the player on waivers for nothing again routine, anze kopitar is his best friend you telling me we couldnt of gotten a 7th round pick and let our scout andersson try his magic again with an extra pick and hope for the best ???
no doubt he will get picked up and i think with the speed he has he can be an nhl player for years and if not now i see him with the kings when hes a ufa
Once again, if you were an NHL GM, what would you pay for an injury prone 3rd/4th line winger that doesn't play physical or score much? Considering, that just about every team has better and more established 3rd/4th line players on their team and even on their AHL team.
I feel like a broken record on these forums sometimes.


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UNIVERSITY PARK- Following are the highlights and lowlights from Penn State's 35-23 loss to Ohio State on Saturday night at Beaver Stadium:
Play of the game: Matt McGloin badly underthrew Alex Kenney over the middle early in the third quarter, and the ball was picked off by Buckeye linebacker Ryan Shazier and returned 17 yards for a touchdown and a 14-7 OSU lead. Penn State never recovered.
Offensive player of the game: Ohio State quarterback Braxton Miller showed off his dual-threat capability by running for 134 yards on 25 carries and two touchdowns and adding another 143 yards passing and another TD.
Defensive player of the game: In addition to his interception and TD, Shazier made seven tackles, including two sacks, and forced a fumble.
Most telling statistic: Penn State was outrushed 234-36 and managed a mere two rushing first downs.
Hidden statistic: Nine penalties for 85 yards didn't help the Lions' cause. Penn State has now been penalized 16 times in the last two weeks.
Best run: Miller broke off a 33-yarder to the PSU 6 late in the second quarter, setting up a touchdown that tied the game at 7-7.
Best pass: Neither quarterback threw the ball particularly well, but Miller rifled a third-down 13-yard slant to Evan Spencer in the third quarter, which gave the Buckeyes a first down at the Lion 9 and set up Ohio State's 28-10 lead a few plays later.
Worst pass: See play of the game.
Best catch: Lion tight end Matt Lehman went up in traffic and took a shot but hung on to a 19-yard reception in the second quarter.
Catch it, will ya: The pass was underthrown, but Allen Robinson had his hands on it and failed to come up with a deep shot on third-and-3 on the Lions' first possession. Better pass is a TD, but a catch still puts Nits in red zone. Stephen Obeng-Agyapong also dropped an early interception with nothing but the end zone in front of him.
Hold it, won't ya: Bill Belton mishandled the second-half kickoff, which didn't help field position.
Best block: Mike Hull broke through to block an Ohio State punt inside the Buckeyes' 5, and Mike Yancich recovered in the end zone to give the Lions a 7-0 lead midway through the second quarter.
Best tackle: Gerald Hodges came off a block to stop Miller early in the open field.
Best hit: Ohio State's Devin Smith (not him, he's at Marshall) nailed Lion punt returner Jesse Della Valle in a one-on-one situation in the first quarter.
Best coverage: There were three very good plays in the end zone. Obang-Agyapong jumped over OSU tight end Jeff Hueurman to break up a TD pass, and Buckeye corner Bradley Roby returned the favor by stripping PSU tight end Kyle Carter of a fourth-quarter TD. Roby then recovered to deflect an underthrown ball to Robinson, who was open but had to wait too long.
Best kick: Alex Butterworth's 44-yard punt pinned Ohio State at its 3 in the first quarter, the Buckeyes took almost the entire first half to climb out.
Worst kick: Butterworth's first punt went 24 yards.
Worst penalty: With the Lions up 7-0, PSU special teamer Brad Bars was hit with a defensive holding penalty on an Ohio State punt, providing a first down for the Buckeyes on their game-tying touchdown drive late in the second quarter.
Best call: With the score tied at 7-7 early in the third quarter, after the Lions gained 6 yards on first down to the Lions' 17, Ohio State unleashed a blitz, and Shazier sacked McGloin for an 11-yard loss. On the next play, third-and-13, McGloin suffered a pick 6.
Worst call: On fourth-and-9 from the Ohio State 43, down 14-10 midway through the third quarter, Bill O'Brien sprung a fake punt with Butterworth throwing to Derek Day. The incomplete pass gave Ohio State good field position.
Best effort: Miller's 1-yard TD run that gave the Buckeyes a 21-10 lead was spectacular. He eluded Sean Stanley, who appeared to blow up the play by decking blocking back Carlos Hyde, then dodged Michael Mauti and Malcolm Willis and dove into the end zone.
Unsung hero(es): Ohio State's defensive line controlled play inside and harassed McGloin into four sacks.


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Jizo Bodhisattva, guardian of children, women, and travelers in the six realms of existence is represented in traditional standing pose. A statue of Jizo is a caring, thoughtful gift for a friend who has suffered a loss. Japanese ironware. Gift box.
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The Central Nebraska Multiple Myeloma Support Group was founded by Mary Lou Russell, a myeloma patient, about seven years ago. Mary Lou has the sparkle and energy of Susie Novis. I serve as the group's facilitator. We meet in a beautiful community room graciously donated by Home Federal, a local bank, on the third Wednesday of every month. The group has become our source of information and support, and I challenge other patients and caregivers to start myeloma groups in their local communities. It only takes one committed person and the help of the IMF. The rewards are enormous!
Our support group had a special treat in September of 2005 when Greg Brozeit, IMF Advocacy Consultant, spoke to our monthly gathering. Greg was to be the first outside speaker to make a presentation at our meetings. Prior to his arrival, Donna Wernke called each member of our group to remind them of the upcoming meeting. Donna faithfully calls our members every month as the meeting day approaches. In September, in addition to Donna's calls, we had promoted Greg's visit at local medical facilities. As a result, our usual attendance of no more than 10 swelled to over 20!
During his presentation, Greg explained how genomics and proteomics are exposing cancer's dark and dirty secrets. All types of this disease are being shown to have similar characteristics. Greg emphasized the commonality of all cancer patients and shared his conviction that the most effective advocacy must take into consideration the needs of the entire cancer community instead of focusing on individual diseases such as breast, prostate, lung cancer, etc. He also pointed out the political realities in Washington, DC, and the unique independent voting patterns of Senator Nelson and Senator Hagel. Greg energized and challenged our group to become more politically active and advocate for cancer research.
We mused over Greg's observation that all of us enjoy the friendships within our group, but if we had our choice we would all prefer to have never been a part of it! But, even though myeloma is the pits, we've turned it into a source of new friends. Through the IMF, that circle has expanded to include Greg, Andy, Robin, Susie, Nancy, Debbie, and many others. Greg's presentation lived up to our advance billing and everyone left the two-hour meeting inspired.
Greg's sojurn to Nebraska had its origin in July as we became re-acquainted during the 2005 IMF Support Group Leader Retreat held at the R. David Thomas Conference Center at Duke University. I asked Greg why he would find Nebraska a worthwhile trip and reminded him that our membership numbers don't come anywhere close to those of the myeloma support groups in Georgia or Texas. His kind answer emphasized quality over quantity and the fact that the IMF is committed to supporting each and every myeloma group regardless of size.


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The Botanical name includes both the plant genus and species. The first name listed is the genus and refers to the structural characteristics that the plants share. The second name listed is the species and refers to where the plant is native, its appearance, or the person credited to its discovery. Varieties, Cultivars, and Hybrid are additional words used to describe further subdivisions.
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A man who served 5 years of active duty was NOT a draft dodger by anyone's definition.My dad barely got out of being drafted because he was over five years in the army already and discharged, and had kids. Does that make him a "draft dodger" like Bush?
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text:
Source: CBS News
quote: Bill Gates will definitely be in the history books while Steve Jobs may only get a brief mention here and there in some business books.
quote: He was forced out of Apple,
quote: and NeXT was a failure.
quote: ...but became the basis for OSX when Jobs returned to Apple. NeXT was just a little ahead of its time.
quote: Hate on the guy all you like, but you can't take away what Jobs was able to accomplish with Apple. And if it weren't for Jobs, Gates and Microsoft might not have been nearly as successful. GUI and object oriented programing would have still been in its infancy. Tablets would still be a niche item, if that. Smartphones/Android wouldn't exist at all.Jobs forced the envelope on a lot of these things, even though he didn't develop the tech himself. He saw potential in tech that others discarded or didn't have a use for.
quote: Without Jobs Apple is starting to look more and more like just another computer company. May as well be Acer but with $140B of liquid cash at its disposal.


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on February 18, 2013 - 1:00 AM
, updated February 18, 2013 at 7:56 AM
A dormitory on the University at Buffalo North Campus in Amherst was evacuated Sunday night as an equipment malfunction near the boiler room caused carbon monoxide to build up in the building.
Two students drove to a hospital, and two others were taken to a hospital by ambulance, according to Joe Brennan, a UB spokesman.
An additional two students – the fifth and sixth in the incident – were evaluated by an ambulance crew and were not taken to a hospital.
The conditions of the students taken to a hospital were not immediately available, but they were not thought to be serious.
Brennan said the incident began to unfold at about 8:30, when students started to feel ill. The dormitory, Richmond Quad, houses as many as 500 students, although it was unclear how many were evacuated. Students who live in the dormitory went to other buildings on campus as they awaited an all-clear signal to re-enter, which was given at 11:15. None of the students had to wait outside in the bone-chilling cold.
National Fuel Gas sent a representative to the scene, and firefighters carried fans into the building to help ventilate it at 10:30.
The state fire marshal had a car at the scene. Also standing by was Twin City Ambulance and a ladder truck from the Getzville Volunteer Fire Company.
email: email@example.com


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That's why I was guessing Florida.
Well that's one way to see if he's gonna go for the money or a chance at a cup....yikes! No way a contender is offering that...unless it's Philly, I guess.
I'm pretty sure they need to get to the floor, they just lost Sammy, and they made the playoffs last season for the first time in 10 years. That salary still sounds ridiculous, but if they won a playoff series, it would almost be worth it financially.


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Top Definition
The CGC or Crazy Girl Clan is a clan of both males and females that hang out together quite a lot and pretty much not a day goes by where they don't have a meeting. This clan originated in the boonies of Verona, NY. The Queen of the clan is labeled the bear and she holds most of the power in the clan in matters such as decision making. The King of this clan is the bear's man, and he thinks that he has power, but it is just an illusion. There are around 10-15 members in the clan. One of the members is a gay. Once a person is associated with the CGC, that person bears the mark on their soul for the rest of eternity.
On a Saturday, the CGC got together in a meeting to determine whether they should give a member the boot. Many opinions were thrown around by both subordinates and the King, but in the end the bear made the final decision to kick that certain member out.
от Nicky WIlliams 07 януари 2008
Trending Now
Can you define these popular missing words?
Crosby gonna Cros. Similar to Haters gonna hate, but named after the person who uses the phrase more than every other person alive, combined, ever.
"You're singing that note wrong", said the bass.
"cgc", said the soprano.
"cgc", said the soprano.
от choirkid 10 октомври 2011
A cheesy gordita crunch, which is usually associated with the fast food franchise Taco Bell.
Hey I'm going to Taco Bell, you want anything?
Yeah get me a CGC will ya?
Yeah get me a CGC will ya?
от ecafracs 01 януари 2010
Cap Gun Comics- The best comics around
damn this is the funniest comic ever and its by cgc
от Pyro88 13 май 2004
the abbreviation for the COOL GIRLS CLUB
yeah the SWEET people are all part of the CGC.
от me 17 юни 2006
Your nothing but a CGC!
от Idon'thavemoneytogetdogfoodfor 21 септември 2016


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The trouble with Harmony: Part 1 | Opensource.com
The trouble with Harmony: Part 1
Harmony, the Canonical-led effort to provide a comprehensive suite of contributor agreements for open source projects, has quietly released its version 1.0, a year after Canonical general counsel Amanda Brock announced the initiative on opensource.com. During most of that year, Harmony's construction took place out of the public view, in deliberations that were cloaked by the Chatham House Rule.
Despite my admiration, respect and affection for those who have been driving Harmony, I cannot endorse the product of their work. I believe Harmony is unnecessary, confusing, and potentially hazardous to open source and free software development.
Contribution policies and free software tradition
For a quarter-century, most free software projects have been characterized by twin norms of transactional informality and licensor equality. Most projects have never used formal contributor agreements. Instead, they have customarily operated under a rule I call "inbound=outbound": in essence, contributions are understood to be licensed in under the applicable outbound project license (or an explicit inbound license is passed through by the project downstream). This makes it easy for meritorious contributors to participate in projects without intimidation and red tape, and puts all project contributors, be they patch submitters or committers, on an equal legal footing. It is a form of legal governance that is so pervasive that I must conclude that the great success of the open source development model owes much to it.
The copyright assignment policies mandated by the Free Software Foundation for the early GNU projects were for many years the main exception to this general social rule. The use of formal contributor agreements has grown in recent times, but it remains a minority approach. Where such agreements are used, there are basically two approaches, which I will call maximalist and minimalist. Maximalist approaches are represented by copyright assignment agreements and by contributor license agreements (CLAs) that require maximally broad inbound copyright license grants. Minimalist approaches may be less well known; they generally involve a simple explicit commitment to use a particular well-known free software license for one's contribution. This is typically either the applicable outbound license of the project (a formalization of the inbound=outbound custom), or some standard permissive license.
Maximalist contributor agreements have been highly controversial in FLOSS development communities, especially in the case of copyright assignment policies required by projects controlled by singular corporate interests. The best examination of this subject remains Michael Meeks' essay "Some thoughts on Copyright Assignment". It may be noted that Canonical announced the Harmony project some months after experiencing widespread community criticism leveled at its own copyright assignment agreement.
The illusion of constraint
Harmony has opted to follow, and thus legitimize, the maximalist approach, but in a new way that I fear may cause confusion. A project using Harmony must first decide whether to require copyright assignment or a maximally-broad inbound copyright license from the contributor; no other choice is given. The project is then expected to choose from a set of five mutually exclusive conditions on how the assigned or licensed-in contribution can be licensed out downstream by the project.
Each of the five options lets the project use the outbound project license as of the contribution submission date, but this is what a project would normally do anyway. (This is not the same as inbound=outbound, because the licensor under Harmony is the inbound project entity, not the contributor.) Four of the five options give the project some alternative to the use of the existing project license. In one of these four cases, the alternative is unrestricted, explicitly allowing the project entity to select any license, free or proprietary. (The project makes a token commitment to "additionally" license out the contribution under the existing project license.) The alternatives under the remaining three options consist of a list of licenses designated by the project, any OSI-approved license, and any FSF-recommended copyleft license.
What is notable about these outbound licensing options is that they are not meaningful, except in the case where the option commits the project entity solely to use of a copyleft license on the outbound side. This will only occur where the existing outbound license is a copyleft license and, if the project gets to pick an alternative license, the alternatives are either a list consisting solely of copyleft licenses, or the "FSF-recommended copyleft" category. In all other cases, the outbound conditions are essentially nominal. That is because, even if the "unrestricted" option is not selected, the project can always license the contribution under a noncopyleft FLOSS license, which by definition will place no outbound licensing constraints on use of the code, including use by the project entity itself.
I am not questioning the legitimacy of permissive licensing; indeed I have encouraged the use of standard noncopyleft licenses by Red Hat developers. What troubles me is that Harmony takes pains to give the appearance of constraining outbound licensing, when in reality this will be so only in one special (and likely rare) case.
To give a simple example, suppose a company launches a new GPL-licensed project and asks contributors to sign a Harmony copyright assignment agreement with the "only OSI-approved licenses" outbound option selected. The company is then entirely free to license out all contributions under, say, the (OSI-approved) 3-clause BSD license, which in turn does nothing to restrict the company from privately licensing the project code, including contributions, under a proprietary, closed-source license. This is not some novel scenario, but what Harmony adds is the illusion of constraint, which I am concerned may mislead contributors who are relatively unfamiliar with open source licensing.
Harmony and GPL enforceability
I have suggested that Harmony's appearance of constraining outbound licensing is real only where the project agrees to license out the contribution solely under a copyleft license like the GPL. But even in this case the maximalist model is in place, as it is in all other Harmony permutations. By assigning copyright to the project entity, or granting it the broadest possible copyright license, the Harmony agreement contributor is giving up all rights to police use of the contribution downstream from the project. This is the sharpest break from the time-honored inbound=outbound tradition: the contributor is cut off entirely from any real legal relationship with downstream users of the project's code. Instead, the contributor is left only with some claim against the project entity, should it violate the grant condition.
Is this good enough? Perhaps for some contributors, in some cases. But a contributor who cares about downstream compliance with the GPL will have no remedy if the project entity makes no effort to enforce such compliance. The expectations of the contributor will lie unmet, yet the contributor will be powerless to do anything about it. Harmony did not create this problem; it is inherent in all existing uses of the maximalist model by GPL projects. But GPL-oriented contributors should not assume that a Harmony agreement with a GPL-outbound constraint will satisfy their policy objectives.
I continue my critique of Harmony in Part 2 of this article.
22 Comments
Fontana, I agree quite completely with your assessments. Your clarity of expression in formally conceptualizing "inbound=outbound" last year really clarified my views on why most CLAs are quite dangerous, and that concept heavily influenced my own essay on Project Harmony's agreements.
I do, however, hope that Red Hat will switch to a pure inbound=outbound approach for the Fedora Project Contributor Agreement (FPCA). FPCA surely gets much closer to inbound=outbound than any Project Harmony permutation, but the degradation back to MIT permissive license as the "Current Default License" means copyleft might not be upheld due to mere forgetfulness on the part of a contributor.
I don't see why a distro needs any form of contributor agreement at all. A distro aggregates a collection of software packages, all under different licenses. The FPCA strikes me as extraordinarily heavy-weight for this context. Patches to software packages should be submitted upstream, under whatever terms the upstream project considers appropriate.
Ubuntu has only the Code of Conduct which has everything to do with being a responsible community member, and nothing to do with software licenses.
You and Dave Neary have saved me the bother of documenting my own concerns with Harmony (where I participated as an act of mitigation rather than endorsement). All the same, when clients ignore all of my arguments on the subject I will probably suggest they use the Harmony agreement (License version, with the community-selected license explicitly identified as the outbound license) rather than write their own.
Something you've not mentioned in detail is the community reasons not to have these kinds of agreement. I've written on the subject from both a community and a corporate perspective.
Will you also be covering the cases where organisations (Apache and Plone come to mind) appear to have put contributor agreements to good use?
Richard, Having participated in a number of calls and meetings, I find your characterization "cloaked by the Chatham House Rule" a tad sensational. As RedHat surely knows, there were no barriers to join the discussion lists and participate in the meetings, and participants were forthcoming about who they were affiliated with.
That said, healthy debate is just that, for another perspective, your readers can follow Stephen Walli's summation and keep the discussion vibrant: http://www.networkworld.com/community/node/76064
Paula, I disagree. Early in the process, Harmony meetings were only announced on private email lists, such as ftf-legal, that are quite difficult to join. Even with 12 years of FLOSS license policy experience, my requests to join ftf-legal have been routinely denied for years.
Therefore, I learned about Harmony only through the rumor mill, and all the information I received about Harmony was only through those rumors until Allison made it a public process in April. Thus, I don't think Fontana has been sensational at all.
Meanwhile, it's still the case that for the pre-April meetings, no one can even tell me which people from what companies were involved in the drafting. I know multiple people who were invited to the meetings (through the lists I mentioned above and some of whom were my source of rumors), yet they remain forbidden from telling me anything due to the Chatham House Rules (a ruleset wholly inappropriate for a process intending to make policy for individual Free Software developers).
This has not been a transparent process in the least. Indeed, as recently as this week, it took multiple requests before the 1.0 documents were released in a transparent format.
I'm not sure why it's difficult to join a mailing list when the only requirement is "ask to join". But, based on feedback after the Alpha release, we switched to entirely public mailing lists with entirely public subscription webforms.
I agree Chatham House Rules were an unfortunate choice. They sound nice and open, encouraging collaboration, but in actual practice they're pretty difficult to work with.
The format of the documents wasn't about transparency, it was actually about my technology blindness. Creative Commons only offers the license picker tool, it didn't occur to me that people might want plain, old-fashioned, static PDFs of the Harmony templates. (I still can't imagine what people are going to use them for. Harmony is a template, you have to modify it before using it, so what good is a static PDF?)
I agree about the continued, dark and spooky "Chatham House Rule" references. After hearing about all this darkness and secrecy on Identi.ca, I signed up on the mailing list in Jan 2011 and have lurked there ever since.
Don't know if the idea is that everything had already been set in stone by then, but it certainly didn't seem that way.
I've seen much talk of how Harmony is going to trick developers, but the phrase Copyright Assignment Agreement tells all. If you sign a copyright assignment agreement, you are agreeing to assign your copyright.
Sure, legalese can be tricky, but the anti-Harmony folks ought to give developers some credit...
Sorry to hear about your experience Bradley, I joined the mailing lists without fan fair in June 2010 and have received well over 450 emails as part of the discussion list. I had no knowledge of the ftf-legal list you referenced.
I assume by mailing lists here you refer specifically to the (now deprecated) private Harmony mailing lists, and not the other private mailing lists (like ftf-legal) that I referred to (i.e., the original places where invitations to the private Harmony lists were sent).
I am not surprised at all that as a leader of a Microsoft-backed trade association, you were explicitly invited to Harmony. From my perspective, by the time invitations found their way into public (sometime in late 2010), key decisions were already faits accomplis, and my joining would have been moot by then. Separately, I also object on principle to personally agreeing to Chatham House rules to engage in Free Software public policy-making.
I find it completely ludicrous that the software freedom community might considering adopting policy documents that were primarily developed under these sorts of secrecy rules. I'm sure this sort of process is common for trade associations like Paula's, but such secrecy has historically caused serious problems and confusion in the software freedom community. Paula, you probably remember well the problems created by secret decision-making at United Linux when you were involved with it. As you and I both learned then, secret decision-making by consortia done without consulting larger software freedom community only causes problems. Harmony is repeating the mistakes of the past.
Thanks for your comments Bradley, to clarify, I asked to join, I was not invited. Re: UnitedLinux LLC, happy to have a cup of coffee with you anytime for a walk down memory lane. It would be a fascinating case study on why LLC's are not the best structure for a non profit organization.
I am pretty sure your backers (e.g., Microsoft) will already be buying some of the coffee breaks at OSCON this year. If you're there, we should meet up during one of the breaks!
I'm glad to see you don't believe LLC's are a good structure for organizations that want to operate in the software freedom community. I assume that means that you, like me, don't find the Open Innovation Network (OIN) well-structured?
Brandley, stop by the Outercurve booth #918, personally I prefer to buy my own coffee, don't like the mass brewed free stuff.
For my part, I try to avoid the mass-brewed nature of the tradeshow floor as much as possible, so hopefully we'll catch up at some talks. I'm speaking on Friday; I hope you'll come. The coffee at Oregon Convention Center is not too bad and the only coffee for purchase is big-corporate Starbucks, which isn't that great anyway. I guess 501(c)(6) types don't mind BigCorp coffee so much though.
The input=output convention is the easiest for small contributors like me to understand (and newbies). Corporations needs written authorization to avoid legal trouble. Hence, the "minimalist" approach seems to serve both needs optimally. The "maximalist" agreements I would call "scary", and I've avoided them after my first encounter. Kudos to Mr. Fontana for the clear and appropriate terminology for these approaches.
Just a follow-up on the Chatham House Rule discussion, one of the reasons good open collaborative development and free software projects work so well is that decisions made in the past can be reviewed via public archiving. When a decision process of who said what is cloaked with anonymity, it is impossible to later recreate and understand why decisions were made. This undermines the ability for a community to learn, self-heal, and improve. Reasoning of past decisions is left to the memory of those who were present, and we know how inaccurate memory can be.
In most communities, it is a good idea to have private spaces for some discussions, but relevant material needs to go back to the public space for all to understand and, if not agree with, at least not be surprised by secret reasoning.


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on October 3, 2012 - 12:27 AM
Although Alex Zordich has struggled with his passing the last two games, University at Buffalo coach Jeff Quinn is sticking with him for the time being.
Zordich, UB's junior quarterback, has completed 48.5 percent of his passes this season (47 of 94) with seven touchdowns and four interceptions. In his last two games against Kent State and Connecticut, however, Zordich is 17 of 52 with three touchdowns and four interceptions.
"This kid is a tremendous competitor," Quinn said. "There's no one who wants to do it and do it right and have success and our team senses that in Alex Zordich. He presses hard. We tell him, 'You're our starting quarterback, you're the guy that we're going with and we just have to get better.' But we also have to be mindful and conscientious of what's best to help us win games. We don't want to lose thought of that, either."
Zordich's backup is redshirt freshman Joe Licata (Williamsville South), who has appeared in two games.
"He's ready to be the next guy in, absolutely, and he's earned his way into the No. 2 spot," Quinn said. "No one has been more supportive of Alex Zordich than Joe Licata. He's all about this team and I'm sure he's chopping at the bit just like a lot of guys are but at the end of the day these kids respect each other; they care about each other, and they want nothing more than to see this team succeed no matter who does it."
Even if Zordich's struggles continue Saturday against Ohio (5-0, 1-0 Mid-American Conference), he's is too versatile to keep on the sidelines. He brings value to the Bulls running game, especially with leading rusher Branden "Bo" Oliver still nursing a leg injury. Zordich led the team in rushing against Connecticut with 76 yards on 14 carries.
"He got us in some chain moving situations, he scrambled, he eluded the rush and those are the things that you're looking for," Quinn said. "If something's not there obviously he can make those plays."
Quinn said not all of the offense's woes can be pinned on Zordich.
"The interception [vs. UConn] was a blocking issue; he got hit right before he released the ball," Quinn said. "That's an offensive line situation. If we throw the ball a little low and a little bit outside on a rollout pass the receiver has to go down dig it up and make it right. It's a collection of things.
"We're going to continue thinking about all the things we need to do to win football games" Quinn added. "Scheme-wise, calls-wise and personnel-wise, we need to keep that in the forefront and it is a topic of discussion every single week."
The Bulls have been quite proficient in the red zone, converting 9 of 9 opportunities and scoring eight touchdowns. UB is one of only four teams to have a 100 percent scoring rate inside the 20-yard line – joining top-ranked Alabama, Oklahoma State and Wake Forest.
"When we have been in there – not enough right now to our liking – we have been very efficient and that's a good thing," Quinn said.
Quinn sounds optimistic that Oliver could return as early as this week at Ohio. Oliver missed last week's game at UConn with an undisclosed leg injury.
"Bo is ready to go but we all know that just his toughness, he's one of those special breeds and we're very fortunate to have him," Quinn said. "We also have to do what's best and everyday he's getting better. He went and saw the doctors [Monday] and doctors said, 'Coach, this kid is doing very, very well.' We're going to keep a close eye on it and see how he does ... and if all signs point to it, I don't want to hold him back. If he's ready to go then he's going to play."
Quinn isn't as optimistic about wide receiver Fred Lee, who is out at least until the latter part of the season with a hand injury.
"We're hoping for maybe a game or two at the end of the season, maybe" Quinn said. "His hand injury is something where you can't jar it, he's a receiver."
Junior fullback Boomer Brock is also out for the Ohio game. The depth chart is unchanged from last week's game against UConn.
email: email@example.com


text:
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is there anyone who would love to talk about anime
hello :) i like anime. what are some of ur favorites?
well isn't this site suposed to be about anime and for people to talk about it
Zombaukto Clan is cool Join
no, not this site jk
HaHaHa your hilariousZombaukto Clan is cool Join
yeah i love to talk about anime !!!!.
it takes me into the world of wonders where nothing is impossible and anything can happen.when i die i want to be resserected as an anime character, to spend eternity amounst the legends of anime. life is a never ending lesson <Zombaukto Legends>
lol same anime is so cool it would be cool to live in an anime world
yap it is all cool .
id love to talk about anime!
~Nan Kuru Nai-Sah~
id soooo love to talk about anime =D :D
awesome due
What do you think this site is about lol. Anime and manga. Is life reality or is it a mirror image of what you want it to be?
"those who keep fighting......what are they fighting for?"
yeah your right. sorry to anyone that thought i sounded like a jerk.(Is life reality or is it a mirror image of what you want it to be?)
when he was on here well use too anyway (~if you want to die stand in my way + if you want to live get out of my way = its your choice so choose wisely~)
(Is life reality or is it a mirror image of what you want it to be?)


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PORTAGE - Portage coach Gary Gouse said that his team was treating Friday night's contest with visiting Blacklick Valley as its first playoff game of the year, and the Mustangs responded with a big second half and went on to a 12-0 victory in a battle of two WestPAC postseason contenders.
"Our defense played great," said Gouse, whose team improved to 5-1 on the season thanks to a stout defensive effort that limited the explosive Vikings (4-2) to just 146 total yards.
The Mustang game plan emphasized containing Blacklick Valley standout Johnny Sheesley, and Gouse's team executed the plan exactly as intended. Sheesley was held to just 30 yards on 17 carries.
"Our defensive end, Paul Husar, played a heck of a game containing Johnny Sheesley," Gouse said. "He's an outstanding athlete, and we bottled him up and didn't let him get loose."
The two high-scoring teams battled to a scoreless tie at halftime.
"We moved the ball a little on our first drive and last drive, but couldn't sustain anything for the whole game," said Blacklick Valley coach Bill Zamboni. "We let them drive the ball and milk the clock in the second half, and we have to find a way to do a better job defensively."
The Mustang ground game came alive in the second half, as Portage churned out 186 of its 303 total rushing yards over the final two quarters. Luke Dividock finished with a game-high 115 yards on 15 carries, while Caleb Kephart added 100 yards on 13 carries.
After the Mustangs wasted an opportunity to get on the board in the second quarter with a red-zone fumble following a 13-play, 81-yard drive, Portage needed just four plays to open the third quarter and grab the lead.
Mustang quarterback Evan Price found an opening around the left side and dashed 39 yards down the sideline for the first touchdown of the night at the 10:36 mark of the period, but the extra point attempt was blocked, keeping the lead at 6-0.
Another lengthy Portage drive went for nought early in the fourth as the Mustangs marched from their own 28 to the Blacklick Valley 3 before another fumble kept Portage out of the end zone and the Vikings in the game.
However, Blacklick failed to capitalize and went three-and-out. A short punt then put Portage in great field position at the Viking 23, and Caleb Kephart subsequently scored from 4 yards out with 5:31 left in the contest to put the Mustangs in control.
The Vikings engineered one more threat as four consecutive Sheesley pass completions covering 41 yards gave Blacklick Valley a first-and-goal at the Mustang 9 with nearly three minutes to play.
However, consecutive incompletions on third and fourth down kept the Vikings out of the end zone and allowed Portage to then run out the last 2:27 and preserve the win.
Blacklick Valley0 0 0 0 - 0
Portage0 0 6 6 - 12
Third quarter
P-Price 39 run (kick failed) 10:36
Fourth quarter
P-Ca. Kephart 4 run (run failed) 5:31
RUSHING: Blacklick Valley -Reigel 10-62, Worthington 3-minus 1, Sheesley 17-30. Portage-Price 13-61, Ca. Kephart 13-100, Co. Kephart 7-27, Dividock 15-115.
PASSING: Blacklick Valley-Sheesley 5-15-0-55. Portage-Price 2-8-0-10
RECEIVING: Blacklick Valley - Paul 3-39, Stutzman 1-14, Worthington 1-2. Portage - Miller 1-4, Dividock 1-6.
INTERCEPTIONS: None.
Team StatsBVP
First downs1019
Passing yards5510
Total yards146313


text:
The 2012 America's Neighborhoods report-97045 for Oregon City, OR provides 2012 estimated demographic data including population demographics, consumer spending, retail businesses and services businesses. America's Neighborhoods reports are published annually by Pinpoint Demographics, a division of Barnes Reports.
2012 population demographics (age, race, income, education, occupation)
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retail businesses (restaurants, pharmacies, gas stations, new car dealers, home centers, clothing stores, supermarkets)
services businesses (physicians, CPAs, consultants, advertising agencies, lawyers, retirement homes, child day care)


text:
Tiffin reports
* A 200-block Benner Street person reported Wednesday night a woman was hit with a PlayStation 3 controller.
County reports
* A 2000-block West CR 30 man reported Wednesday evening hunting items were stolen from a wooded area.
* A 100-block Siesta Drive man reported Wednesday night someone took a laptop, money and a computer.
* Tiffin Police advised the sheriff's office a woman reported her mother had assaulted her on East TR 1179.
* A woman reported Thursday afternoon a mobile home she owned in the 2000 block of North CR 60 was vandalized.
Fostoria reports
* A caller from Friendship Sunoco, 526 Sandusky St., reported Thursday morning someone stole items from the store Wednesday evening.
* A 300-block West Lytle Street woman reported Thursday morning someone had been getting into her vehicle and putting the seat down as if they were sleeping inside of it.
Tiffin accident
* Catherine J. Balliet, 59, of Sycamore, was cited with failure to control following an accident Thursday morning at South Washington and Circular streets.
Fostoria Municipal Court
* Ernest S. Franklin, 334 McDougal St., speed, $117; Andre Murphy Jr., 725 S. Main St., speed, $153; Tammy L. Livesay, 638 Buckley St., speed, $156; Ronnie J. Jervis Jr., Lorain, disorderly conduct, $115; Richard A. Weis, Toledo, speed, $117; Brandon T. Reinhart, 202 N. Union St., passenger seat belt violation, $65; Louis C. Arbogast, 404 Burnham Drive, failure to control, $125; Earl A. Kreais, Fostoria, failure to yield, $125; Monnie N. Harden, Fostoria, assured clear distance, $125; Tina K. Sherer, Bradner, red light violation, $125.
* Dwight L. Struble, Fostoria, disorderly conduct, $115; Angela M. Struble, Fostoria, disorderly conduct, $115; Lisa M. Fredritz, Carey, speed, $105; Carl T. Snowden, 420 N. Main St., failure to control, $125; Justin A. Morel, Risingsun, speed, $111; Catherine A. Sampson, Fostoria, assured clear distance, $125; Gary A. Stahl Jr., 214 E. Eagle St., speed, $123; Richard A. Ross, St. Peters, Mo., changing lanes without regard to safety, $125; Jordan L. Powell, 350 Columbus Ave., changing lanes without regard to safety, $125; Denice L. Short, Findlay, speed, $114.
* Wyatt S. Ault, Findlay, speed, $129; Elizabeth C. Wargo, Toledo, speed, $123; Esaias S. Malagon, Fostoria, start/back violation, $125; Stacy L. Molnar, Northwood, assured clear distance, $125.


text:
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text:
CHICAGO, IL -- Speaking at the opening session of Solar Power International 2013 -- the largest solar trade show in America -- Rhone Resch, president and CEO of the Solar Energy Industries Association delivered the following remarks:
Good afternoon everyone. Welcome to Chicago. Welcome to SPI 2013. And welcome to the Big Leagues.


text:
Sunday, Dirk Nowitzki and the Dallas Mavericks defeated LeBron James, Dwyane Wade and the Miami Heat to end the season and begin the offseason. Unfortunately for the NBA and its fans, this offseason could resemble the NFL's offseason if a lockout is implemented.
As of now, teams can trade with each other. The current CBA ends June 30th and free agency begins July 1st.
Plenty of trades should go down on draft day, like usual, but don't expect a rush of free-agent signings this year, obviously. Hopefully the NBA is a more flexible league than the NFL.
The two biggest trade rumors going into the offseason have surrounded Dwight Howard and Monta Ellis. Howard wants to stay in Orlando, but he could end up going anywhere at this point as long as it's to a contender. Ellis has been closely linked to the Philadelphia 76ers in a trade for Andre Iguodala, but other teams are in the race for the guards services as well.
Stay tuned for more updates on the latest free agent buzz and top trade rumors throughout the day.


text:
on February 13, 2013 - 12:19 AM
By Steven L. Dubovsky
The provision in New York State's new gun legislation requiring mental health professionals to report patients who may be likely to harm themselves or others will turn doctors into agents of the state.
Psychiatry practice rests on the premise that the doctor is an agent of the patient who is there to protect and help the patient. A cornerstone of that premise is confidentiality. As soon as you say, "What you say may be reported to the authorities," people will stop saying what's really going on, or they may stay away completely.
According to the provision, if a psychiatrist or therapist thinks that a patient might cause harm, he or she is required to report it to the State Office of Mental Health, which will inform police who would check that patient's name against a database of gun owners.
That would require the patient's Social Security number, which psychiatrists do not have. If police find that this patient has a gun permit, do they call the patient or visit the patient's house? Do they obtain a search warrant? What else do they do? It doesn't say.
This idea is misdirected. The vast majority of murders are committed by people with no mental disorder. Those with mental illnesses who do become violent constitute a tiny minority of people with such diagnoses. On the other hand, it is very common for all people – not just those with mental disorders – to entertain violent fantasies. But no prospective research tells clinicians how to identify who will pose a danger next month, next year or ever.
What is meant by mental illness? Schizophrenia? Mania? Depression? Anxiety? Bulimia? Adjustment disorders? Substance abuse? Around 40 percent of the population meets criteria for a mental disorder.
People think that anyone who commits mass murder must be mentally ill. It is certainly correct that such behavior is abnormal, but it does not inevitably reflect mental illness. Were Hitler and Ted Bundy psychotic or just evil?
The Newtown murderer is said to have had a psychiatric diagnosis not associated with deliberate, premeditated murder. Most killers are likely not to have a psychiatric diagnosis. Reporting people with psychiatric diagnoses therefore represents profiling that has an extremely low likelihood of being useful. If the American people have consistently rejected racial and religious profiling, why is profiling on the basis of mental disorders suddenly permissible?
With this legislation, a precedent has been established to make physicians into auxiliary police agents and to report suspicions, rather than facts. Societies that have taken this step have done so at the expense of the liberty of their own citizens.
Steven L. Dubovsky, M.D., is professor and chairman of the Department of Psychiatry at the University at Buffalo School of Medicine and Biomedical Sciences.


text:
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
LC-MS Gains Favor Due To the...
Developers of DTC Genetic Testing Are...
Integral membrane proteins such as GPCRs, ion channels, and transporters are a large family of proteins responsible for detecting and transmitting extracellular signals into cells and comprise nearly 50% of existing drug targets. Approximately 40% of all membrane proteins contain multiple hydrophobic transmembrane domains, enabling them to span the cell's lipid bilayer up to two dozen times and adopt complex tertiary and quaternary structures.
Monoclonal antibodies (mAbs) against membrane proteins, especially those that recognize conformation-dependent epitopes, are valuable as diagnostic and therapeutic agents because they can bind to critical structures of the receptor that can be exploited for specific detection or functional inhibition. However, the development of such mAbs is especially difficult because most membrane proteins are challenging to express and purify in large quantities, and their extraction from cell membranes often results in loss of native structure.
Phage display technology is a powerful approach for isolating human antibodies, where genetically modified phage carrying antibody fragments are used for panning and screening of antibody libraries (Figure 1A). Phage display enables screening of large and diverse antibody libraries (>1010 variants), allows for modifiable in vitro selection conditions for deriving antibodies with specific functionalities, and bypasses immune tolerance limitations, facilitating the selection of affinity reagents against even highly conserved protein targets.
However, phage panning with membrane protein antigens presents a unique set of challenges, including a requirement for high concentrations of target proteins that are not easily purified, a propensity for phage to stick nonspecifically to charged lipids and glycoproteins on cell membranes, and the need to retain native membrane protein structures during capture and panning procedures.
As a result of these limitations, phage display has largely focused on soluble proteins to date, with less than a dozen phage-derived mAbs in clinical studies targeting unique membrane proteins, nearly all of which are single transmembrane proteins rather than more complex multi-transmembrane proteins.
Integral Molecular is combining its Lipoparticle technology with optimized phage protocols to overcome the specific challenges associated with phage display for isolating antibodies against membrane protein targets (Figure 1B). Lipoparticles incorporate high concentrations of properly folded and oriented membrane proteins on their surface, such as specific GPCRs, ion channels, or transporters. Membrane proteins are incorporated on Lipoparticles at concentrations of 50–200 pmol/mg, 10 to 100 fold greater than cells or membrane preparations, providing a highly enriched target for phage clone selection.
Lipoparticles are particularly well suited for phage display as they are small (~150 nm), stable, and can be biotinylated, enabling efficient capture to commonly used streptavidin surfaces. Furthermore, Lipoparticles can be made without target receptors (Null Lipoparticles) or from heterologous cell types (human, murine, avian, etc.), enabling controlled negative selection steps and improved recovery of antigen-specific clones.
Conventional phage display protocols have now been optimized with Lipoparticle antigens, resulting in sensitive and specific selection of antibodies directed against membrane protein targets.
In a controlled panning experiment comparing a membrane protein antigen on Lipoparticles versus the same antigen in its purified form, similar numbers of reactive clones were recovered, demonstrating equivalent sensitivity between antigen types (Figure 1C).
Optimized phage panning with Lipoparticles provides enrichment of target-specific clones, with a round-dependent increase in reactivity and no significant reactivity against Null Lipoparticles (Figure 1D). Optimization of phage display with Lipoparticles is now enabling antibody campaigns against a wide variety of membrane protein classes, including GPCRs, ion channels, transporters, viral envelopes, and other complex multi-transmembrane protein targets.
Integral Molecular and its partners are now using phage display with Lipoparticle technology to isolate specific and functional human antibodies from different types of phage libraries. Phage panning using synthetic or naïve human libraries provides a broad source of antibody diversity, but also requires increased panning sensitivity to recover the small numbers of reactive phage clones represented in each library.
Using Lipoparticles and optimized protocols, a naïve library was panned for antibodies against the seven-transmembrane GPCR CXCR4. A large number of individual phage clones was isolated, each showing specific reactivity against the membrane protein target and little to no reactivity against Null Lipoparticles (Figure 2A). Successful isolation of reactive clones from a naïve library demonstrates the utility of Lipoparticles for providing not only sufficient antigen concentration but also optimized sensitivity.
To isolate reactive mAbs against a viral target, Lipoparticles containing a viral Envelope protein were used to pan an enriched phage library derived from B cells of infected patients. A large panel of individual phage clones was isolated, each clone showing strong and specific reactivity to the viral Envelope protein (Figure 2B, left panel).
Several of the mAbs isolated were capable of strongly neutralizing infection of target cells at sub-nanomolar concentrations (IC50 <0.1 μg/mL) (Figure 2B, right panel). Because membrane proteins retain their native conformation in Lipoparticles, panning with Lipoparticles increases the likelihood of recovering functional antibodies that can be further developed as therapeutic candidates.
Lipoparticle technology, offering high concentrations of native membrane protein antigens, biotinylated formats for easy capture, and optimized protocols for use with diverse phage libraries, enables sensitive and specific detection of reactive antibodies against membrane protein targets. Lipoparticles expand the application of phage technology to this large class of underexploited targets for therapeutic mAb development.
Eli Berdougo, Ph.D. ([email protected]), scientific communications, Kimberly Mattia is a research scientist II, and Benjamin J. Doranz, Ph.D., is president and CSO at Integral Molecular.
Eli Berdougo, Ph.D. ([email protected]), scientific communications, Kimberly Mattia is a research scientist II, and Benjamin J. Doranz, Ph.D., is president and CSO at Integral Molecular.
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Evling is a smart, beautiful, nice, caring person. She has a beautiful smile that makes everyone go crazy. Her personality is amazing, you can get along with her the first day you guys start talking. She has killer ayes and a beautiful laugh. She's extremely ticklish and smell really good. She's very giggly funny and loving. You must approach to evling first because they'll rarely approach to you first. Evling is faithful to her friends and people she likes/loves. She's sometimes shy but gets crazy when she's confident around you. She's very kind and will never leave you down. Evling hates fake bitches so be real to her and there will be no problem. So if you get to meet her you're so damn lucky! & good look finding girls like her.
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A simple, uplifting track that combines a soft piano, acoustic guitar and bass with a slight ambiance effect to give it that special something. The track has a warm, enveloping quality that I feel would lend itself well to a corporate video, ad campaign, or possibly something romantic?
The zip file contains both mp3 and wav versions of the track.
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Source: Consumer Reports
quote: But independent studies (JD Power) show that customers don't really care for the system.
quote: And while I agree with you on Ford being the best out there, you'd say that regardless of any merit because they were the only one that wasn't bailed out ;-)
quote: Need more info. Do they have issues with the CONCEPT, or it's implementation? Implementation can always be tweaked. But what CR seems to have an issue with, is the core concept of MyTouch.
quote: You can't change the inherent "flaw" in the system. It's a touch screen-based system that require you take your eyes off the road. There's no fixing that.
quote: Isn't this supposed to be a tech site? I mean on DT cars that drive themselves seem to be VERY popular with the readership. Yet a touch screen Ford is some kind of deal breaker? Wtf kind of thinking is that?
quote: Try typing on an iPad blindfolded and see what I mean.
quote: Try typing on an iPad blindfolded and see what I mean. Now try typing on a standard QWERTY keyboard blindfolded.
quote: Yea I can see that they would want to push this on us even if we didn't really know if we wanted it
quote: Bottom line: a touch panel is total crap as an interface for the driver.


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PES used to be like a member of the family. It'd be there in times of need. No matter what was going on in your life, it would be sat inside your PS2's disk tray, waiting to be spun into action. Many of us saw more PES than we did sunlight, and it even had a convenient pause during set-pieces that allowed everyone to quickly sip a cold beverage. Then things got nasty. FIFA muscled in as PES got lazy. Years of being BFFs caused PES to get complacent, and with every passing year FIFA upped its game until PES was banished to the game shelf. Konami promised changes, but with each new game came further disappointment. Times have changed. FIFA rules and PES is essentially a generation late to the party. Now it's the turn of PES 2011, which true to form comes packed with the lure of all manner of improvements that hope to wake the sleeping giant. But we've been let down before.
While it's still a bit early to say for sure if things have changed for the better (some might argue things couldn't get much worse), things have changed, and in some cases quite dramatically. What's apparent from my initial exhibition matches is how tricky it is to score. This is down to significant modifications to both defending and attacking.
The age-old 'hold X to pressure and tackle' system is still here, but it's been tweaked to offer more options. Hold X (we're talking the PS3 version here, but there'll be an equivalent on other platforms) and point the left analogue stick at your own goal and your defender will fairly unspectacularly just try to stop the attacker advancing on goal. He won't be able to easily run past you, but you're not going to win the ball unless the ball happens to hit you. The second option is to let go of the stick completely while holding X. Your player will stop, but attempt to win the ball. Finally there's the more risky, lunge-like tackle, performed by holding X and pointing the stick at the man in possession.
It's not a revolution by any means, but certainly makes attacking an altogether more difficult task. Combine this with a strong emphasis on individual player characteristics and stats and you have a game that's already more in-depth and realistic than any PES I've played before. In a friendly game here in the office, in which both players picked England, at one point nippy but small winger Aaron Lennon burst free only to come face to face with man-giant Ledley King. Despite Lennon's pace, King was able to use his brute force to push the pint-sized dynamo away from the penalty area.
Your options when on the ball needed to be enhanced to match the improved defending, and that's exactly what Konami has done. Most notable is more precise control over your player, with supposed full 360-degree movement. I can't say if it actually is that precise, but it's a hell of a lot better than what we got last year. The feint system has also been reworked, with L1 and the right analogue stick working in tandem to give your player a bit of space to get off a shot or nip past a defender. Of course, tight control is a must, with only the best players (like cover star Lionel Messi) able to exploit these moves fully.


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SOUTH LAKE TAHOE, Calif. - The Tahoe Derby Dames faced the Port City Roller Girls from Stockton on June 16 at Bijou Community Park in their first home bout of the season. Both teams fielded an "A" and "B" team for a total of two bouts.
According to a press release from the Dames, the first bout, between the "B" teams, included a mix of intermediate and "fresh-meat" skaters from both teams.
"The green team played their hearts out. Great team work and determination won the game," Bunny Darko, captain for the "B" team, stated in the release. "For many of the girls it was their first bouting experience. It would be impossible to pinpoint just one skater as MVP because it took the entire team to win the game. Keep an eye out for these up-and-coming skaters this season."
Cryma Passion was the star jammer for the "B" team, helping the them to a winning score of 115-87. The team offered MVP recognition to TuTu Tootsie in her first bout. Bunny Darko was voted best blocker.
"What a way to open up the home bouting season," said coach Jack Hammer. "The 'B' team exceeded my expectations. They played smart, physical derby. I am thrilled with their dedication and passion for the game."
The Dames veteran skaters laced up the skates against Port City's A team. They had a rough start, but managed a strong second half. It wasn't enough to keep Port City from winning though, with the team from Stockton beating Tahoe 159-113.
"The TDD 'A' team continues to grow and move forward. Their determination to finish this last bout was so inspiring," Jack Hammer said. "I really thought we came together in the second half. We outscored Port City by 40 points. Such an incredible group of skaters."
TDD has grown to more than 40 skaters and will be hosting double headers this summer, The Tahoe Derby Dames next home bout is July 21, at Bijou Community Park.


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Nearly 26 million Americans suffer from a disease that affects their entire bodies from head to toe, and another 79 million have a condition that puts them at higher risk for developing it.
With numbers like that, it's hard to ignore the problems that come from diabetes.
The statistics from the American Diabetes Association are sobering when compared to the rates of other diseases, and they say the numbers are only growing, as more Americans become overweight and raise their risks for the disease.
Article Photos
Photo courtesy Altoona Regional Health System
Clinical manager Dave Bickers, CRNP, WOCN, and patient Bernard "Bubba" Smith of Everett at the entrance of the hyperbaric oxygen chamber. Altoona Regional's Wound, Ostomy and Hyperbaric Medicine department offers hyperbaric therapy through two state-of-the-art total body chambers. Hyperoxygenation of wound tissue can promote and accelerate wound healing.
Diabetes - in its simplest definition -?is excess sugar in the blood. Because blood flows to every single organ and every part of the body, diabetes can negatively affect the whole body if it's not diagnosed and treated properly.
Dr. Haleh Haerian, an endocrinologist at Blair Medical Associates, Altoona, said diabetes is a disorder that disrupts how the body uses glucose, or sugar. All the cells in the body need sugar to work normally and use the help of a hormone called insulin to get the sugar into the cells.
"One can consider insulin as a key that opens a door to let the sugar in the cells," Haerian said. "If there is not enough insulin, sugar builds up in the blood and the cells starve from lack of nutrition. That is what happens to people with diabetes."
She said there are two types of diabetes. In type 1, the patient's pancreas does not make enough insulin. In type 2, the body becomes resistant to insulin and does not respond well to insulin, so the body's cells are not opening to the sugar.
About 90 percent of people with diabetes have type 2, Haerian said.
That's good news and bad news. The good news is that type 2 can sometimes be prevented before it becomes full-blown diabetes by lifestyle changes, and once it is diagnosed, it can be treated by the same changes along with medication. The bad news is that it affects the entire body and can lead to disastrous consequences if it is not managed consistently.
There are some risk factors that raise a person's chance of developing type 2, said Pat Rose, a certified diabetes educator at Altoona Regional Health Systems.
"There is a really strong genetic predisposition," Rose said. "If you have a family history, you are more likely to develop it."
Dr. Haerian said someone with a first-degree relative who has type 2 diabetes is five to 10 times more likely to also develop it. The rate is higher in certain ethnic groups, including people of Hispanic, African and Asian descent, she said.
The other two major risk factors are being overweight and lack of physical activity, Rose said.
While anybody can develop diabetes, those at risk should be screened regularly with a simple fasting blood test that will measure the amount of sugar in the blood, she said. Type 2 can develop for a long time without symptoms, but the most common signs are drinking a lot, eating a lot, frequent urination, weight loss and fatigue.
Dr. Haerian also recommended that adults at higher risk should be tested. They include adults with a body mass index over 25 who have one or more additional risk factors such as family history, lack of exercise, high blood pressure, high cholesterol or gestational diabetes.
She recommended testing begin after age 45 for adults without any of those risk factors.
Rose said even those at higher risk can take action to prevent developing diabetes or try to head it off when it is in the pre-diabetes stage, as recognized by the ADA.
"It requires some work," Rose said.
Haerian said that the problem might start in the body as many as 10 to 20 years before diabetes is ever diagnosed. She explained that the body can gradually become resistant to the effects of insulin, meaning more and more insulin is needed to do the same job. As long as the pancreas is able to meet those demands, the blood sugar will stay normal and cells will be fed.
"It takes several years for the pancreas to finally not be able to meet the body's demand, both due to progressive increase of demand and to exhaustion of an overworked pancreas," she said. Most people will not be diagnosed for another five to 10 years when enough sugar builds up and insulin production declines.
But the preventative measures can slow down the progression, prevent or delay the development of diabetes, Haerian said.
That comes back to the work of the patient.
"You do need to learn how to meal plan and learn the importance of become more active," Rose said.
Even a small amount of weight loss, maybe as little as seven percent of body weight, can make a difference and prevent diabetes, she said.
"Maintain a healthy weight and be physically active most days for about 30 minutes. Make healthy food choices," Rose said.
Since diabetes affects the way the body uses sugar, that is one of the things that needs to be regulated, especially after diabetes is diagnosed. But Rose stressed making lifestyle changes now that will make the entire body healthier, whether a patient is at risk for diabetes or already has it.
"People have to learn how to meal plan, not to go on a diet. It's a four-letter word - diet - that a lot of people think has to do with losing weight and then going back off it. This is meal planning that has to be a lifestyle change," she said.
That's exactly what is taught by Dona Baughman, clinical nutritional manager and registered dietician at Altoona Regional Health Systems.
"Almost every food you eat has an effect on blood sugar," she said. "People with normal blood sugar, their bodies will adapt and keep it where it needs to be. People who can't produce insulin or who are not producing enough, they have to watch how it will affect blood sugar."
The first thing she recommends to patients is to control the intake of carbohydrates such as bread, cereal, starches and fruits because they have immediate effects on blood sugar, but they can also lead to weight gain in the future. Balancing foods will lead to more consistent blood sugar and healthy weight.
"Carbohydrate consistency is the key," Baughman said. "Each meal should have the same amount of carbohydrates, and it should be the same from one day to the next so the body can predict that you're going to eat and what it needs to produce."
She tells patients to eat the same amount of carbohydrates, whether they are coming from an apple or a brownie, because the body will use the sugar the same way. However, she wants her patients to learn that the apple is a better choice overall because it has more nutrients and healthy things like fiber while the brownie doesn't. Fiber has also been shown to help control blood sugar.
"We try to steer people to better foods and better choices," she said.
Part of that is teaching people to make the food choices long-term and manageable in everyday life, including understanding and changing portion sizes.
"It's a process," she said. "You are making changes you can keep forever."
Along with better eating choices, Rose recommended people get more active doing physical activities. She provides pedometers to the patients she counsels to help them see that even adding extra steps each day can slowly build exercise.
Along with lifestyle changes in eating and exercise, Dr. Haerian said there several different oral medications are available to treat type 2 diabetes. Some work to reduce the insulin resistance, while others increase insulin production. There are also three injectable medicines that increase insulin production while they help weight loss. Of course, there are the insulins themselves which Haerian said come in many different forms and may need to be injected.
In order to know if the treatment is working, patients can use a blood glucose monitor at home to check their blood sugar levels while the doctor will do blood tests every three months to evaluate if the treatment is effective, Haerian said.
Since diabetes affects the entire body, if blood sugar is not managed properly, it can lead to many different complications. Rose said the most common are cardiovascular disease, peripheral artery disease, cerebral vascular disease as well as eye, kidney and nerve damage. She said diabetes is the leading cause of non-traumatic limb amputation in America as well as the leading cause of blindness in people ages 20 to 74.
Some of those complications are seen every day by Dave Bickers, manager of wound, ostomy and hyperbaric medicine at Altoona Regional Health System. He said many of the things he sees could have been prevented with better maintenance of blood sugar.
"We usually end up seeing people after problems with diabetes," he said. "Diet and education, trying to prevent this end of it, really is the key to preventing the complications of diabetes."
The most common problem he sees are diabetic foot ulcers which can be very common in people with uncontrolled diabetes. Those ulcers may take three to six months to heal, even with specialized care every other week at the hospital.
"The main thing we see for diabetics is when the blood sugar is too high, it affects your ability to heal," Bickers said. "The body's natural healing mechanism is slowed down by too much sugar in the blood. The sugar gets in the way of healing."
That's why diabetes raises the risk of peripheral vascular disease, he said. While artery disease is often thought of blocking blood flow in and around the heart, in diabetics, that blood flow also decreases to the rest of the body, especially the hands and feet, Bickers said.
"It slows the healing process there on top of hardening the arteries so there's less blood which makes it even harder to heal," he explained.
Along with that comes damage to the nerves, or neuropathy, which causes a patient to lose feeling and sensation to extremities, he said.
"A lot of diabetics we see can't feel their feet," he said.
Since they can't feel their feet, they may not realize they are developing a sore or painful spot which can grow into an ulcer. And since blood flow is already decreased, a small sore can grow to become a big problem very quickly since it won't heal naturally, Bickers said.
On top of that, diabetes can actually change the way the body is supposed to react to an illness or injury.
"Diabetes will actually mask infection," Bickers said. "You might have an infection in the body and while a normal person would have a fever and be sick, a diabetic might not show a temperature until two days later and by then, the infection has time to grow much worse. By the time you see the infection, it's a really bad infection."
Besides wounds, coronary artery disease is more common among diabetics as well as the risk for stroke, blindness and kidney disease, he said.
"It's sped up by not keeping blood sugars under control. If you aren't paying attention to [blood sugar], it just really is a way to speed up trouble," Bickers said. "It really is a terrible disease. It affects every part of your body."
Rose said many of the complications can ultimately be avoided if a diabetes patient works at helping him or herself.
"Diabetes is self-managed for the most part," she said, adding that the patient has the power to help themselves get well if they follow the course. She recommended those diagnosed with diabetes should attend educational classes to learn about diet and managing their diabetes.
"The issue is control. You are in control of it," Rose said.
Once diagnosed, maintaining blood sugar is the key. Rose said patients should make sure to attend all their doctor appointments where they will be screened for complications and check their own blood sugar as instructed.
If someone is diagnosed with diabetes, Rose said they should get education about it and make the lifestyle changes to better their treatment. If someone is at risk and wants to prevent diabetes, they should make those same healthy changes.
"You can see it change for the better. These are things we should have been doing all along anyway," Rose said. "It's about deciding what you want to do and making a plan to do it."


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Rahul Gandhi, Shinde Decline to Meet US Delegation
By IANS - NEW DELHI
Published: 17th December 2013 12:10 PM
Last Updated: 17th December 2013 02:17 PM
Congress vice president Rahul Gandhi and union Home Minister Sushilkumar Shinde Tuesday declined to meet a US Congressional delegation to highlight India's strong disapproval of the arrest and handcuffing of an Indian diplomat in New York last week.
The diplomatic snub comes a day after Lok Sabha Speaker Meira Kumar and National Security Advisor Shivshankar Menon cancelled their meetings separately with the visiting US delegation.
The NSA is known to have described the treatment meted out to Devyani Khobragade, India's deputy consul general in New York, as "despicable" and "barbaric", a source told IANS.
Khobragade was strip searched, confined in a cell with drug addicts and also subjected to DNA swabbing, sources confirmed to IANS.
Speaker Meira Kumar, herself a former Indian diplomat, declined to meet the US delegation, comprising Republican and Democrat members, "as a sign of displeasure" over the treatment meted out Khobragade.
Khobragade, one of India's senior diplomats in New York, was charged last week with visa fraud and making false statements.
She was accused by Manhattan's Indian American US Attorney Preet Bharara of visa fraud and exploiting her babysitter and housekeeper. She was handcuffed in public by law enforcement authorities in New York Thursday while she was dropping her daughter at school.
India has termed the treatment meted out to the envoy as "absolutely unacceptable". US Ambassador Nancy Powell was summoned to South Block by Foreign Secretary Sujatha Singh December 13 and a strong protest lodged over the treatment.
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