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|Direct Imaging of Asymmetric Magnetization Reversal
The phenomenon of exchange bias has transformed how data is read on magnetic hard disks and created an explosion in their information storage density. However, it remains poorly understood, and even the fundamental mechanism of magnetic reversal for exchange-biased systems in changing magnetic fields is unclear. By using x-ray photoemission electron microscopy at the ALS to directly image the magnetic structure of an exchange-biased film, a team from the University of Washington and the Stanford Synchrotron Radiation Laboratory has identified separate magnetic-reversal mechanisms in the two branches of a hysteresis loop. This advance in fundamental understanding will provide new insights for developing the next generation of information storage and sensing devices where exchange bias is expected to play a critical role.
There are two basic energies involved in the manipulation and control of the magnetic properties of materials. Exchange controls magnetic order, and anisotropy controls magnetic orientation. A soft ferromagnet such as iron has a large exchange parameter but a small anisotropy, making ferromagnetic order stable at higher temperatures but with an unpredictable orientation of the magnetization, especially in structures of nanoscale dimensions. On the other hand, many antiferromagnets have weak exchange interactions (low ordering or Néel temperatures) but large anisotropies that result in very stable orientations.
Exchange bias arises when a thin ferromagnetic film is grown on an antiferromagnet and the resulting heterostructure is cooled in a magnetic field through the Néel temperature of the antiferromagnet. As a result of exchange coupling between the layers, the ferromagnet both retains a stable order and gains a higher anisotropy at room temperature. Moreover, the unidirectional character of the anisotropy results in a shifted hysteresis loop that is now centered on a non-zero magnetic field. This exchange bias makes the ferromagnet an excellent magnetic reference layer in modern nanolayer magnetic devices because it is very difficult to demagnetize it.
More than fifty years of research has provided varying insight into the exchange-bias phenomenon but not yet a comprehensive description of all its salient features. To gain more insight, the Washington–Stanford team resorted to x-ray photoemission electron microscopy (PEEM) imaging of high-quality single-crystal ferromagnetic iron epitaxially grown on antiferromagnetic MnPd (all on an MgO substrate), samples that had been previously well-characterized magnetically and structurally.
At an iron absorption resonance, absorption of circularly polarized x rays at ALS Beamline 220.127.116.11 is sensitive to the angle between the magnetization within a ferromagnetic domain and the polarization vector. With the PEEM-2 microscope, this x-ray magnetic circular dichroism (XMCD) effect allows an exact determination of the direction of the local domain magnetization at the surface of ferromagnets with a spatial resolution of 50 nm or less.
By means of XMCD measurements taken at points in hysteresis loops with the applied field in different crystallographic directions of the iron ferromagnet, the team has accumulated the first direct imaging evidence for an asymmetry in the magnetic-reversal mechanism in exchange-biased systems, evidence that until now has only been inferred indirectly by measurements such as neutron scattering.
Normally, magnetic reversal in ferromagnets occurs either by coherent rotation of magnetic moments in the domain or by nucleation and growth of reverse domains. Generally, the mechanism is determined by the material microstructure and is symmetric with respect to the applied field, i.e., it is the same in both branches of the hysteresis loop. However, the team found that in exchanged-biased ferromagnetic iron, the magnetization reversal occurs by moment rotation for decreasing fields, while it proceeds by domain nucleation and growth for increasing fields. The observed domains are also consistent with the crystallography of the bilayers and favor a configuration that minimizes the overall magnetostatic energy of the ferromagnetic layer.
Research conducted by P. Blomqvist and K.M. Krishnan (University of Washington) and H. Ohldag (Stanford Synchrotron Radiation Laboratory).
Research funding: U.S. Department of Energy, Office of Basic Energy Sciences (BES). Operation of the ALS is supported by BES.
Publication about this research: P. Blomqvist, K.M. Krishnan, and H. Ohldag, "Direct imaging of asymmetric magnetization reversal in exchange-biased Fe/MnPd bilayers by x-ray photoemission electron microscopy," Phys. Rev. Lett. 94, 107203 (2005).


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Holland, Stan Bowman and Paul Holmgren sat down for a conversation with ESPN's Pierre LeBrun regarding possible trade mindsets for their respective teams.
When the conversation came around to the Red Wings needs, Kenny Holland says the phrase we all know we LOVE to hear... (emphasis mine)
Just getting healthy, if that ever happens, will be like making a few trades for Detroit, which has yet to play with a fully healthy lineup this season.
"If we can get all our guys back, that's almost like a deadline addition or two," Holland said.
LeBrun wraps up the Wings section nicely by pointing out the Wings would like a top-4 D man, but that might be hard to get come deadline time. I'd recommend giving the full story a read.

subset: commoncrawl


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Top Definition
When a girl sits in between two dudes and jacks them off simultaneously as if she were using their cocks as ski poles
Juanita loves to ski slope her two best male friends, Bryan and Rob.
dari DramaDramaDrama Sabtu, 15 November 2008
Trending Now
Can you define these popular missing words?
an adjective used to describe a woman or a girl's breasts. The breasts are shaped in a elongated curve resembling that of a ski slope. Very uncommon and very undesirable to many.
That girl at the bar last night had a nasty set of ski slopes - I mean seriously, they should be registered for the winter olympics.
dari eastondle Rabu, 23 September 2009
The action of male ejaculation on a someone's ass crack and letting the sperm ski down.
I decided to give her a ski slope, so I pulled out and shot it on her ass.
dari El Cid Sabtu, 21 Juni 2003
When a girl sits naked on her back with her ass to the bed's edge and her legs up in the air. The guy stands at the foot of the bed holding her legs like ski pulls and fucks her while moving her legs back and forth while going "swish, swish, swish"
John totally ski-sloped that bitch, she was a real black diamond. It was the best ski slope this week.
dari 1n1 & Fun Senin, 24 Januari 2011
to have a nose so long that it reseambles a ski slope.
that girl's nose is so long it looks like a ski slope.
dari ApR!L like the month only better Senin, 24 Maret 2003


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SURPRISE GIVEAWAY: Rosanna
Ready to set a seriously chic table? Because with today's fantastic surprise giveaway from Rosanna, now's your chance to do just that!
Rosanna is a line of contemporary dishware and tabletop accessories by designer Rosanna Bowles. Spend just a few moments browsing their website, and you're sure to discover fantastic designs that run the gamut from decidedly sophisticated to playful, modern & fun. Today, Rosanna is generously offering up their cool, eclectic Boho collection – which includes 6 porcelain dinner plates and 6 porcelain dessert plates – to one very lucky hwtm reader! ($146 retail value!) Check it out…
With the Boho collection, several different patterns + several different colors come together to create one surprisingly cohesive – not to mention gorgeous – tabletop!
Ready to snap up the Boho set for yourself?
Tell us what your favorite Rosanna dinnerware design is – or just make any comment here to enter the sweepstakes! Remember to use either your blogger login or first name / last name or initial so we can identify you if you win.
Giveaway ends Saturday, Sept 8th at midnight PST! Good luck! :)
Comments 255
- posted in:
- In the Spotlight
1ellie SAYS:
I've been a fan of Rosanna for a long time – and I LOVE the parisian wallpaper design! Love this one too though – count me in!
2yvonne m. SAYS:
what a BEAUTIFUL table this set makes!!!
3wen SAYS:
Wow! I love this stuff. This would make my desserts look even better. I love the boho set the best and love the green dotted plates. I also love the playing house cake stands, I am going to order some of those. My fingers are crossed.
4faith s. SAYS:
I really love the unique shapes of the plates! such a cool designer touch!
5Brooke SAYS:
The Rococo Noir is AMAZING, but then they all are. I have my fingers crossed tightly!!
6Sharleen SAYS:
7susan foster SAYS:
I actually really love THIS set! Especially the green circles and blue swirlies patterns from this set. would LOVE to win! (HINT, HINT!) :)
8lily SAYS:
love it!! want it!!
9Meg Kling SAYS:
so pretty! i love them! all my colors in such fun designs! pick me please!
10Mae S. SAYS:
I love them all too! They are too cute!!!!
11Jasmin SAYS:
Pretty please for such pretty things? Thanks.
12Gwendolyn SAYS:
My favorite Rosanna dinnerwear is red dots…for Christmas, Valentine's, any day that needs perking up….
Gwen Johnson
13nancy SAYS:
picking a favorite is just too tough! I love all the holiday stuff though…so my "favorite" will be an entire category :)
14Katie SAYS:
These are so cute! I love the blue/white combo as well as the dark green leafy one. I am OBSESSED! I am moving soon and just got rid of my old mismatched "college" plates…these would be SO nice to have in my new, grown up place. :)
15mindy m. SAYS:
OH. MY. GOODNESS! For a girl that is absolutely in love with the shapes of letters & numbers (yeah, I'm a nerd), handsdown my favorite is Party Raffle. Seriously, how cool are these?!?!
16jessica a. SAYS:
ok – i seriously gasped when I saw the picture with all the plates set out together! i want MY table to look like that, please!!
my fave is Boho actually (Rococo Noir is a close second, though!)…And my birthday is the day the Giveaway ends (sept 8th)… **fingers crossed!!**
18Jenny SAYS:
These would make a great addition to my kitchen. Soda fountain looks fun.
19Carrie M. SAYS:
Boho is probably my favorite, but the Marie Antoinette design is a close second!
20Megs SAYS:
What beautiful stuff and perfect for my new place.


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on April 23, 2013 - 4:56 PM
FREDONIA – A fire that destroyed two buildings Monday afternoon at the Hills Trucking Inc. on Webster Road in the Town of Pomfret was ruled caused by a battery or electrical system short circuit in a semi-tractor trailer that had been moved inside the company's mechanical garage for repair, Chautauqua County Sheriff's fire investigators ruled Tuesday.
The fire caused explosions to propane tanks stored inside the garage and took about 100 firefighters from 16 companies nearly two hours to control. It began about 30 minutes after the semi was moved into the garage. Employees heard noises coming from the garage, saw the semi on fire on called 911. Before fire crews could start operations to deal with the fire a steady wind caused the fire to ignite tires and fuel.
The fire, ruled accidental, caused no injuries.


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ANAHEIM — The organizers for the Retail Tour at the 2012 Fresh Summit presented a wide range of retailers.
We saw ethnic, from shelves piled high with Hispanic favorites like peppers and cactus leaves at Northgate Gonzalez Market, to jack fruit, packaged greens and live crabs snapping next to the produce department at 99 Ranch Market.
We also saw upscale at the Newport Beach Pavilions, a Vons/Safeway banner. At this smaller format store, the produce department carried the most SKUs we saw all day, along with many grab and go meal solutions and an expanded premium juice section.
Dick Spezzano, tour leader on the bus I rode, said he's seen stores like this Pavilions dedicate much more space to the premium juice category over the past several years. Retailers continue to see double digit growth in this sector, he said.
We also got to poke around in a Fresh & Easy Neighborhood Market, the Tesco banner that's celebrating its 5th anniversary next month. While there were way fewer SKUs at Fresh & Easy, the offerings were diverse. I saw fresh shrimp ceviche, salads and meal solutions, and a large selection of pumpkins for Halloween and fall decorating.
The crowd on the retail tour also was diverse, with many international attendees.
If you didn't get a chance to go, stay tuned to the PR blog as I plan to share photos from the visit as soon as I get them uploaded.


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Cedar Cold Frame
Item# 8587093
Product Actions
Additional Information
Exclusive | Cold Frame Protects Plants and Extends the Growing Season
- Start gardening earlier in spring and grow later into fall
- Sized to fit our 2' x 8' Elevated Cedar Raised Bed or may be used on the ground
- Beautiful, rot-resistant cedar base with aluminum and polycarbonate top
- Watch: Our Vermont Factory
- How much soil? Use the Soil Calculator to figure out how much you need for this raised bed
Sized to fit neatly atop our 2' x 8' Elevated Cedar Raised Bed, this attractive cold frame may also be used on the ground to start seeds, harden off transplants, and grow greens and other cool-season crops. The narrow footprint makes it ideal for setting up along your driveway or walkway, or install it next to your house. The base is made from rot-resistant cedar with aluminum corners. The top is made with polycarbonate panels that diffuse light so plants don't "cook," and there are adjustable braces to hold panels at various intervals for ventilation.
Product Details
- Assembly required
- Cedar, polycarbonate, aluminum
- 8' L x 2' W
- 7-1/4" H at the front, 14-3/4" high at the back
- Gardener's Supply Exclusive
Product InstructionsDownload instructions for Cedar Cold Frame as a PDF
- Sorry, no shipments to AA,AE,AF,AK,AP,GU,HI,PR,VI
- Faster shipping methods, including FedEx Ground, are not available for this item.
- Please provide a physical street address for delivery.


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on February 21, 2013 - 12:14 AM
, updated February 21, 2013 at 12:39 AM
Playing career
1979 Drafted by the Sabres in the second round, 32nd overall, in NHL Entry Draft.
1985-86 Scored 20 goals in 54 games, the most goals he would score in one season.
1987-89 Served as captain of the Sabres. In 1989 he was traded to the New York Rangers in exchange for a draft pick, used to select Richard Smehlik.
• Ruff played in 691 NHL games, scoring 105 goals and adding 195 assists for 300 points with 1,264 penalty minutes. In 52 playoff games, Ruff had 11 goals, 13 assists and 193 penalty minutes.
Coaching career
1993-97 Served as an assistant coach of the Florida Panthers.
July 21, 1997
Named the 15th head coach of the Buffalo Sabres. In his first season, the Sabres advanced to the Eastern Conference finals, losing to Washington.
Sabres sweep Ottawa in four games in the first round and then beat the Bruins and the Maple Leafs to reach the Stanley Cup finals for the second time in team history, eventually losing to the Dallas Stars in six.
Led the Sabres to back-to-back Eastern Conference finals appearances only to lose to Carolina in 2006 and Ottawa in 2007. He was the NHL Coach of the Year in 2006.
Named an associate coach for Team Canada, which won the gold medal at the 2010 Olympics in Vancouver.
Jan. 6, 2011
Became only the 16th coach in NHL history to win 500 games, and just the second to win 500 games while only having coached one team.
Feb. 20, 2013
Ruff is fired after coaching 1,165 regular-season games for Buffalo, compiling 571 wins, 432 losses, 78 ties and 84 overtime losses.


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A man who investigators say is responsible for attacks on law enforcement officers in Osceola County is set to be sentenced Thursday.
David Penney, 20, may be sentenced to eight years in prison as part of a plea deal.
Penney is accused of using two AK-47 rifles to shoot at two St. Cloud Police Department officers in November 2011.
One of the officers was hit in the foot.
Penney originally faced charges of attempted first-degree murder on a law enforcement officer. Those charges were dropped.


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For more information or to schedule an appointment, please call 847.570.1700.
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En Español
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Parathyroid cancer is a rare disease in which malignant (cancer) cells form in the tissues of a parathyroid gland.
The parathyroid glands are four pea-sized organs found in the neck near the thyroid gland. The parathyroid glands make parathyroid hormone (PTH or parathormone). PTH helps the body use and store calcium to keep the calcium in the blood at normal levels.
Anatomy of the thyroid and parathyroid glands. The thyroid gland lies at the base of the throat near the trachea. It is shaped like a butterfly, with the right lobe and left lobe connected by a thin piece of tissue called the isthmus. The parathyroid glands are four pea-sized organs found in the neck near the thyroid. The thyroid and parathyroid glands make hormones.
A parathyroid gland may become overactive and make too much PTH, a condition called hyperparathyroidism. Hyperparathyroidism can occur when a benign tumor (noncancer), called an adenoma, forms on one of the parathyroid glands, and causes it to grow and become overactive. Sometimes hyperparathyroidism can be caused by parathyroid cancer, but this is very rare.
The extra PTH causes:
This condition is called hypercalcemia (too much calcium in the blood).
The hypercalcemia caused by hyperparathyroidism is more serious and life-threatening than parathyroid cancer itself and treating hypercalcemia is as important as treating the cancer.
Having certain inherited disorders can increase the risk of developing parathyroid cancer.
Anything that increases the chance of getting a disease is called a risk factor. Risk factors for parathyroid cancer include the following rare disorders that are inherited (passed down from parent to child):
Treatment with radiation therapy may increase the risk of developing a parathyroid adenoma.
Signs and symptoms of parathyroid cancer include weakness, feeling tired, and a lump in the neck.
Most parathyroid cancer signs and symptoms are caused by the hypercalcemia that develops. Signs and symptoms of hypercalcemia include the following:
Other signs and symptoms of parathyroid cancer include the following:
Other conditions may cause the same signs and symptoms as parathyroid cancer. Check with your doctor if you have any of these problems.
Tests that examine the neck and blood are used to detect (find) and diagnose parathyroid cancer.
Once blood tests are done and hyperparathyroidism is diagnosed, imaging tests may be done to help find which of the parathyroid glands is overactive. Sometimes the parathyroid glands are hard to find and imaging tests are done to find exactly where they are.
Parathyroid cancer may be hard to diagnose because the cells of a benign parathyroid adenoma and a malignant parathyroid cancer look alike. The patient's symptoms, blood levels of calcium and parathyroid hormone, and characteristics of the tumor are also used to make a diagnosis.
The following tests and procedures may be used:
Certain factors affect prognosis (chance of recovery) and treatment options.
The prognosis (chance of recovery) and treatment options depend on the following:
After parathyroid cancer has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body.
The process used to find out if cancer has spread to other parts of the body is called staging. The following imaging tests may be used to determine if cancer has spread to other parts of the body such as the lungs, liver, bone, heart, pancreas, or lymph nodes:
There are three ways that cancer spreads in the body.
Cancer can spread through tissue, the lymph system, and the blood:
Cancer may spread from where it began to other parts of the body.
When cancer spreads to another part of the body, it is called metastasis. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood.
The metastatic tumor is the same type of cancer as the primary tumor. For example, if parathyroid cancer spreads to the lung, the cancer cells in the lung are actually parathyroid cancer cells. The disease is metastatic parathyroid cancer, not lung cancer.
There is no standard staging process for parathyroid cancer.
Parathyroid cancer is described as either localized or metastatic:
Recurrent parathyroid cancer is cancer that has recurred (come back) after it has been treated. More than half of patients have a recurrence. The parathyroid cancer usually recurs between 2 and 5 years after the first surgery, but can recur up to 20 years later. It usually comes back in the tissues or lymph nodes of the neck. High blood calcium levels that appear after treatment may be the first sign of recurrence.
There are different types of treatment for patients with parathyroid cancer.
Different types of treatment are available for patients with parathyroid cancer. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
Treatment includes control of hypercalcemia (too much calcium in the blood) in patients who have an overactive parathyroid gland.
In order to reduce the amount of parathyroid hormone that is being made and control the level of calcium in the blood, as much of the tumor as possible is removed in surgery. For patients who cannot have surgery, medication may be used.
Four types of standard treatment are used:
Surgery (removing the cancer in an operation) is the most common treatment for parathyroid cancer that is in the parathyroid glands or has spread to other parts of the body. Because parathyroid cancer grows very slowly, cancer that has spread to other parts of the body may be removed by surgery in order to cure the patient or control the effects of the disease for a long time. Before surgery, treatment is given to control hypercalcemia.
The following surgical procedures may be used:
Surgery for parathyroid cancer sometimes damages nerves of the vocal cords. There are treatments to help with speech problems caused by this nerve damage.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or stop them from growing. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal rad iation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type and stage of the cancer being treated.
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.
Supportive care
Supportive care is given to lessen the problems caused by the disease or its treatment. Supportive care for hypercalcemia caused by parathyroid cancer may include the following:
New types of treatment are being tested in clinical trials.
Information about clinical trials is available from the NCI Web site.
Patients may want to think about taking part in a clinical trial.
For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.
Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.
Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.
Clinical trials are taking place in many parts of the country. See the Treatment Options section that follows for links to current treatment clinical trials. These have been retrieved from NCI's listing of clinical trials.
Follow-up tests may be needed.
Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.
Parathyroid cancer often recurs. Patients should have regular check-ups for the rest of their lives, to find and treat recurrences early.
Localized Parathyroid Cancer
Treatment of localized parathyroid cancer may include the following:
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with localized parathyroid cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.
Metastatic Parathyroid Cancer
Treatment of metastatic parathyroid cancer may include the following:
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with metastatic parathyroid cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.
Recurrent Parathyroid Cancer
Treatment of recurrent parathyroid cancer may include the following:
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent parathyroid cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.
For more information from the National Cancer Institute about parathyroid cancer, see the Parathyroid Cancer Home Page.
For general cancer information and other resources from the National Cancer Institute, see the following:
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Editorial changes were made to this summary.
About PDQ
Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.
PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government's center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.
Purpose of This Summary
This PDQ cancer information summary has current information about the treatment of parathyroid cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.
Reviewers and Updates
Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change.
The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board.
Clinical Trial Information
A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
Clinical trials are listed in PDQ and can be found online at NCI's Web site. Many cancer doctors who take part in clinical trials are also listed in PDQ. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237).
Permission to Use This Summary
PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as "NCI's PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary]."
The best way to cite this PDQ summary is:
National Cancer Institute: PDQ® Parathyroid Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified <MM/DD/YYYY>. Available at: http://www.cancer.gov/types/parathyroid/patient/parathyroid-treatment-pdq. Accessed <MM/DD/YYYY>.
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The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.
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More information about contacting us or receiving help with the Cancer.gov Web site can be found on our Contact Us for Help page. Questions can also be submitted to Cancer.gov through the Web site's E-mail Us.
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For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.
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The NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support and resources for cancer patients and their families. For a quick search, use the search box in the upper right corner of each Web page. The results for a wide range of search terms will include a list of "Best Bets," editorially chosen Web pages that are most closely related to the search term entered.
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Last Revised: 2015-07-02
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The Stetson men's soccer team will take to the pitch on Sunday for the Hatters only contest of the weekend. Stetson will host first year Division I member Grand Canyon at 7:00 p.m. at the Athletic Training Center.
The Hatters are coming off of a 1-1 opening weekend, which included a thrilling overtime victory over UMass Lowell on Friday. After senior Evan Jimmo's golden goal lifted Stetson to victory, the Hatters went to Tampa and fell to USF late in the game on a penalty kick.
Sunday night's contest in DeLand will have general admission tickets priced at $5 for adults and $4 for seniors and students. All home soccer matches are free to Stetson students, faculty, and staff with a Stetson University ID. For more information call (386) 738-HATS.
For fans unable to make it to the ATC on Sunday, live video will be available on Hatter Vision with Ryan Rouse on the call. Live Stats at GoHatters.com, the @StetsonMSoccer Twitter feed, and the Hat-Alerts text service are also available for in-game updates.
• Stetson opened the 2013 season with a 1-0 overtime victory over UMass Lowell.
• Senior Evan Jimmo scored the game-winner against the River Hawks, just over one minute into the first overtime period.
• Senior Andreas Schnabl's shutout against UMass Lowell was the 13th of his career, which is a school record.
• Schnabl also currently tops the Stetson record books with a career goals-against average of 1.19.
• Stetson lost its second game of the 2013 campaign, falling on the road at USF 1-0 on a late penalty kick.
• Grand Canyon is in its first season of NCAA Division I play. The Antelopes went 15-3-2 in Division II competition last season.
• The Hatters and the 'Lopes have never faced off in men's soccer action before.
• Grand Canyon faced a familiar foe for the Hatters on Thursday. The 'Lopes lost to A-Sun member Jacksonville 3-1.


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As the debate on guns heats up, some startling arguments are coming from both left and right, with a few leaving us at a loss for words.
There is the liberal argument that banning semi-automatic rifles will stop the mass murders, and then there is the conservative argument of the NRA that says the only way to stop bad guys with guns are good guys with guns. The thing is, who decides who the good guys are?
Now another gun enthusiast, Larry Ward, has told CNN that if blacks had guns they would never have been enslaved.
"I think Martin Luther King Jr. would agree with me if he were alive today that if African Americans had been given the right to keep and bear arms from day one of the country's founding, perhaps slavery might not have been a chapter in our history," Ward told CNN host Carol Costello.
If he's talking guns as the ultimate protector and deterrent of wrongdoing or evil, then he must know that America would not have been if the original people who lived here, those we call "Native Americans," also had guns.
CNN host Piers Morgan recently called one of his pro-gun guests an "unbelievably stupid man," and indeed the raging gun talks seem to have brought out some idiocy. Ward is planning a "Gun Appreciation Day" to coincide with President Obama's inauguration and Martin Luther King Jr. Day. His above reference to Dr. King, the noted non-violent civil rights leader, is an obvious cheap ploy to ingratiate himself with blacks. (See video above for more.)
But he must know that blacks and guns are not viewed the same as whites with guns. All this loud defense of the Second Amendment like it's the Holy Grail, one would think that conservatives have never, ever tampered or changed anything about it, right?
So you can imagine my surprise to find out that former President Ronald Reagan, the champion of conservative leaders, had visited those scared gun laws when blacks wanted to carry guns.
In 1967, when the Black Panthers wanted to carry guns to protect themselves from an obviously racist police force, the National Rifle Association supported Reagan, then California's governor, in passing the Mulford Act. This law, which was named after Assemblyman Don Mulford, barred the public from carrying loaded firearms.
And that wasn't the only time the godfather of conservatism supported a ban on guns. He also supported the 1991 Brady Bill. The bill was named after his White House press secretary, James S. Brady, who was permanently disabled after being shot in the assassination attempt on Reagan in 1981.
Reagan though it was "just plain common sense that there be a waiting period to allow local law-enforcement officials to conduct background check on those who wish to buy a handgun." He wanted a seven-day waiting period. These days, many states have none.
So as the NRA tells supporters that Reagan knew the value of gun ownership, they should tell them that Reagan also knew that gun ownership should be regulated for we no longer live in the wild, wild West.
"Messing" with the Second Amendment is not as sacrilegious as some conservatives will have us believe. It can be done.
In fact, the Second Amendment does not sanction unchecked and unregulated weapons in the hands of the public. It clearly calls for some rules before we strap on our guns, and in those days the rules applied to muskets. Could you imagine the Founding Fathers' consternation if they could see the Bushmaster and other rapid-fire killing machines?
One of my smart Facebook friends, S. Tamar, wrote this on the social network, "It seems to me that GUN CONTROL requirement is written into the Second amendment: 'A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed' PEOPLE QUOTE THIS AND SOMEHOW MISS THE "WELL REGULATED" PART."
I couldn't have stated it any better.


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To narrow the focus a bit, the ALS has an important role to play in addressing a number of environmental issues, including environmental remediation, hazardous-waste management, global climate change, agricultural sustainability, and trace-element cycling in ecosystems. These problems present major scientific challenges, in part because natural systems are extremely complex at a range of scales. Moreover, the behavior of these systems is determined by a complex interplay of chemical, physical, and biological processes in spatially heterogeneous environments. The ALS can contribute to the knowledge base needed to address a variety of environmental issues by enabling a variety of investigations, including analytical chemistry, microscopy of heterogeneous media, and reaction kinetics in natural systems.
Geoscience/Environment Highlights
Aerosol Oxidation Speeds Up in Smoggy Air
Manganese Reduction-Oxidation Drives Plant Debris Decomposition
Space Dust Analysis Could Provide Clues to Solar System Origins
Evidence for a Weak Iron Core at Earth's Center
Iron Availability in the Southern Ocean
Studying the Solar System's Chemical Recipe
New Species of Cyanobacteria Forms Intracellular Carbonates
Direct Kinetic Measurements of a Criegee Intermediate
Mineral Deformation at Earth's Core–Mantle Boundary
Molecular Measurements of the Deep-Sea Oil Plume in the Gulf of Mexico
Real-Time Chemical Imaging of Bacterial Biofilm Development
Preservation of Fe(II) by Carbon-Rich Matrices in Hydrothermal Plumes
Experimental Test of Self-Shielding in VUV Photodissociation of CO
Isotope and Temperature Effects in Liquid Water Probed by Soft X Rays
The Iron Spin Transition in the Earth's Lower Mantle
Formation of Metallic Copper Nanoparticles at the Soil-Root Interface
Extracellular Proteins Promote Zinc Sulfide Aggregation
Particles from Comet 81P/Wild 2 Viewed by ALS Microscopes
Ultrafast Core-Hole Induced Dynamics in Water
Time-Resolved Study of Bonding in Liquid Carbon
Enol Intermediates Unexpectedly Found in Flames
Composition and Reactions of Atmospheric Aerosol Particles
Energetics of Hydrogen Bond Network Rearrangements in Liquid Water


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Forest fires are generally consciously or unconsciously the work of man for various reasons. Fires generated byvoltaic arc between power lines and the underlying trees do not occur often. These few cases may be only demonstratedby analyzing around the site where the arc may have been generated. Material such as leaves, bark and soil can beanalyzed to find the metallic residues from the fused cables. The electrical cables usually composed of aluminum orcopper alloys, when involved in an electric arc may spray fused micro-drops of metals, increasing the natural levelof such elements. In two cases, the Al and Cu concentrations were increased by between 2.56 to 13.9 times thebackground levels. Electron microscopy of leaf surfaces has identified some profound alterations produced by theintense heat of the electrical discharge.
Read more...
In 2009-2013, U.S. fire departments responded to an estimated average of 56,000 structure fires per year in homes that involved heating equipment. These fires resulted in annual losses of 470 civilian deaths, 1,490 civilian injuries, and $1.0 billion in direct property damage. These homes included one- and two-family homes (including manufactured homes) and apartments (including townhouses and other multi-family dwellings).Space heaters are the type of equipment most often involved in home heating equipment fires, figuring in two of every five fires (40%). The fires involving space heaters accounted for 84% of the civilian deaths and 75% of civilian injuries in home fires caused by heating equipment, as well as over half (52%) of direct property damage. Another one-third (32%) of fires involved a fireplace or chimney, but these fires accounted for a much smaller share of civilian fatalities (5%) and civilian injuries (6%). Central heat and water heaters were responsible for 12% and 10% of home fires caused by heating equipment, respectively.
By Charles C. Roberts, Jr., Ph. D., P.E.
Automobile engine coolant related fires may result from engine coolant leakage,an increase in the concentration of the glycol in the water/glycol mixture, thenature of the vapor/particle distribution, and contact with an ignition source inthe engine compartment. Ethylene glycol, a common coolant, is a flammableliquid with an ignition temperature near 800F. In recent years, propylene glycolis being used because of environmental reasons. Propylene glycol is also aflammable liquid with an ignition temperature near 700F. In an automotiveapplication, the glycol is mixed with water at about a 50/50 ratio. Ignition of thisconcentration of coolant is difficult because of the water. When released at hightemperatures into the atmosphere where the water evaporates, the glycolvapor/liquid droplets can reach the state of an ignitable mixture. Typical ignitionsources in the engine compartment include hot surfaces (exhaust manifold,exhaust system) and electrical components (relays, distributor, spark plug wires).Automobile accidents, resulting in hot vapor expulsion from the coolant system,are also known to cause fires.
In this paper, we review the research results about the identification of the electrical fire trace evidence and the fire reason recognition. We point out the existing problems and put forward the corresponding suggestions to promote the development of the cause of the fire investigation and make it better to serve for the work of fire investigation.
Read more...
From Out of the Abyss...
This week's article from the past is titled Incendiary Fires Can Be Spotted and was written by Benjamin Horton, CPCU, who was President of the National Adjuster Traing School in Louisville, Kentucky.. It is taken from the Decembe 1968 Vol. XVI No.5 issue.
Incendiary Fires Can Be Spotted
In the new issue of NFPA Journal®, President Jim Shannon said the Association will focus on the leading causes of home fires, including cooking. "We also need to continue to push hard for home fire sprinklers. That's still a large priority for NFPA, and we plan to work very aggressively in 2014 on our residential sprinkler initiative," he said.
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Christopher Michael Sciortino, M.D., M.S., Ph.D.
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Expertise: Aortic Aneurysms, Aortic Root Replacement, Aortic Surgery, Aortic Valve Repair, Aortic Valve Sparing Root Replacement, Cardiac Surgery, Coronary Artery Bypass Graft Surgery, Coronary Artery Stenting, Coronary Bypass Surgery, Endovascular Aortic Surgery, Heart Failure, Heart Transplant, Minimally Invasive Valve Surgery, Mitral Valve Repair, Thoracic Aortic Aneurysms, Valvular Heart Surgery ...read more
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Dr. Sciortino graduated from Case Western Reserve University Medical School and completed a residency in general surgery at Johns Hopkins University School of Medicine. After his cardiothoracic surgical fellowship at Johns Hopkins University School of Medicine, he joined the faculty in 2013.
Among Dr. Sciortino's research interests are minimizing postoperative infections and complications, particularly with high-risk patients. He is also interested in studying heart failure outcomes after cardiac surgery as well as biomechanical device development and the biophysics of heart function.
Dr. Sciortino strongly believes in patient- and family-centered medicine and the importance of including patients and their family members in decisions regarding medical care and rehabilitation.
- Assistant Professor of Surgery
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Arman Kilic; Joshua C. Grimm; Glenn J.R. Whitman; Ashish S. Shah; Kaushik Mandal; John V. Conte; Christopher M. Sciortino. The survival benefit of simultaneous heart-kidney transplantation extends beyond dialysis-dependent patients. Annals of Thoracic Surgery. 2015; 99(4):1321-1327.
Joshua C. Grimm; Anahita M. Parsee; Jeffrey A. Brinker; Irvin Birenbaum; James E. Biewer; Rosanne B. Sheinberg; Christopher M. Sciortino. Utilization of angiovac and snare for eradication of a mobile right atrial thrombus. Annals of Thoracic Surgery. 2015; 99(2):698-700.
Joshua C. Grimm; Keki R. Balsara; Clinton D. Kemp; Jared Miller; Mollie Myers; Steven P. Schulman; Christopher M. Sciortino. Extracorporeal membrane oxygenation for profound cardiogenic shock due to cocaine toxicity. Journal of Cardiology Cases. 2015;11(1):28-31.
Joshua C. Grimm; Cecillia Lui; Arman Kilic; Vicente Valero; Christopher M. Sciortino; Glenn J.R. Whitman; Ashish S. Shah. A risk score to predict acute renal failure in adult patients after lung transplantation. Annals of Thoracic Surgery. 2015;99(1):251-257.
Arman Kilic; Joshua C. Grimm; Ashish S. Shah; John V. Conte; Glenn J.R. Whitman; Christopher M. Sciortino. An easily calculable and highly predictive risk index for postoperative renal failure after heart transplantation. Journal of Thoracic and Cardiovascular Surgery. 2014;148(3):1099-1105.
George J. Arnaoutakis; Yue Zhao; Timothy J. George; Christopher M. Sciortino; Patrick M. McCarthy; John V. Conte. Surgical repair of ventricular septal defect after myocardial infarction: Outcomes from the society of thoracic surgeons national database. Annals of Thoracic Surgery. 2012;94(2):436-444.
Fizan Abdullah; Yiyi Zhang; Christopher Sciortino; Melissa Camp; Alodia Gabre-Kidan; Mitchell R. Price; David C. Chang. Congenital diaphragmatic hernia: Outcome review of 2,173 surgical repairs in US infants. Pediatric Surgery International. 2009;25(12):1059-1064.


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The new 50,000-square-foot Summit Entertainment Center opened Wednesday near the corner of Fairgrounds Avenue and Crossroads Boulevard, offering a new attraction that the town of Windsor hopes will spur more retail activity on the southwest corner of town.
During a VIP event Tuesday evening, attendees had the chance to see the new entertainment center in action. Employees offered samples of food and drinks to attendees that had the chance to tour the facility and roll bowling balls down The Summit's brand-new lanes.
The entertainment center features 32 bowling lanes, a two-story laser tag arena, a 175-seat Crossroads Tavern and Grille, and a VIP lounge offering eight lanes of bowling underneath two big-screen TVs.
"It's been in the works for several years. It's been a labor of love," General Manager Joe Rosner said. "It's an amazing feeling."
Currently, The Summit has 189 employees on its payroll, but plans to grow to about 220 employees after it has finished hiring some remaining seasonal and part-time workers, Rosner said.
"We've bumped up the employment here in Northern Colorado," he said.
One 16-year-old employee, Hayden Ernst, said employees began training Aug. 12 to get ready for The Summit's opening.
"It's been fun so far," he said. "The training really brought us together as a team."
Windsor Economic Development Director Stacy Johnson said the The Summit's opening was an amazing accomplishment that represented years of hard work through partnerships between private developers and the town. She said the town of Windsor offered incentives of about $642,000 to assist in building infrastructure.
"We pushed so hard knowing this is our only corner down here," Johnson said. "Hopefully, it's the spark down here that ignites some retail activity in the area."


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No Sign Of Hailey Dunn; Residents Turn To Power Of Prayer
COLORADO CITY, Texas - Twenty days into the disappearance of 13-year-old Colorado City girl Hailey Dunn, her community is determined to keep a positive attitude, and many are turning to prayer for answers.
Temple Christian Church was filled with music and praise like any other Sunday, but on Sunday they say their thoughts are plagued with someone missing from the service.
"Hailey, she came to this church and she studied and she learned, and I think that she had Jesus in her life," said Machelle Strain, who attends Christian Temple.
The disappearance of Hailey has rattled this close-knit community and with so many unanswered questions, many are turning to prayer.
"We tend to put Jesus away for a rainy day and when storms come in our life, we tend to know in our heart of hearts that the only person that can really help us is Jesus," said Strain.
"The Word tells us, there is power in prayer and with the Hailey Dunn case, as long as it's gone on, God's ways are bigger than our ways. They're different than our ways," said Shane Johnson, associate pastor for Christian Temple.
On Dec. 27, now nearly three weeks ago, Dunn vanished.
Her mother's former live-in boyfriend, Shawn Adkins, was the last to see her.
He told KTXS she said she was walking to a friend's house for a sleepover, but she never made it.
Adkins is the only named suspect in the case.
However, in an exclusive interview with AP he denied hurting the teen.
And with so many developments and speculations, many in Colorado City and all around the country say it's important to stay positive.
"I believe that without hope, we tend to let our mind believe bad things have happened to her, and I think that we need to be strong and have faith in our Father who I know knows exactly where she is," said Strain.


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Tuesday, March 12, 2013
A taxi driver had to call police because a fare jumped out of his cab and took off, leaving a fee of $36 unpaid.
The cab driver told police that someone from the port authority called and asked him to pick up an intoxicated individual.
They told the driver the man was drunk and lost, according to the polics report.
The driver picked the man up and was told to go to a neighborhood off of Chuck Dawley Boulevard. When the cab driver got onto Bowman Road, the passenger told the cab he was going to wrong way. In order to please his client, the cab driver made a U-turn.
The passenger then borrowed the cab driver's phone and called his friend.
Then the passenger asked the driver to stop so he could smoke a cigarette.
The cab driver pulled into a parking lot and the passenger got out of the cab to smoke.
But he didn't stand there long. The driver told police that the passenger took off running.
Later in the evening the cab driver saw the passenger walking around town and he pulled over and told him he needed to pay his fare or he would be turned over to police.
The passenger then took off running again.
That's when the cab driver called police. The officers went to the intended address and spoke with the resident who said the suspect was in town visiting and headed to another state to look for a job.
The resident told police they had been at an event on Longpoint Road all day and the suspect got drunk. He explained that the group of friends then got into a fight with the suspect and the suspect left the event on foot.
The resident said the suspect did not have his cell phone with him, but the friends agreed to go out looking for him and make him turn himself in.
An officer was called to a local bar because of a disturbance. When he arrived he began speaking with two employees to see what was going on. About that time a loud, crazy woman came up to the officer very quickly, according to the report. She began telling the officer in a loud voice that he needed to just go ahead and arrest her and get the whole thing over with. He asked her to calm down, according to the report, but she screamed at the officer and told him she would not calm down. So, the officer did as she asked and handcuffed and took her to jail for drunkenness. But, before the officer drove on to the jail, he spoke with the bouncer who said that the suspect had been in the bar earlier in the evening and was drunk. When she tried to open a tab, the bartenders refused to serve her.
They even tried to explain to her that they could not serve her or they could be charged with over service. The suspect then became irate, he explained to the officer. She started walking around the bar and spoke to three men.
It turns out those men had met her earlier in the evening and she demanded that they drop her off at this bar. They initially came in with her, but left after she started causing a ruckus.
After the men left, the bouncer explained, she started looking for her debit card in her purse and could not find it. She started accusing the bartenders of taking it and not giving it back. But because the bartenders refused her service they had never even touched the card.
The customer then cussed the bartender and demanded her card back, the report showed. That's when this six foot something, 200 pound something bouncer got involved. He tried to escort her outside, he told the officer, but she fell into him. Then she demanded that the bouncer let her go or she would not step one foot outside.
The bouncer said his hands were no where near her.
He told the woman as such and she followed him outside.
Once outside she found her debit card. Then she got on her cell phone and began calling people and telling them that the bouncer at the bar punched her in the face and then threw her into the curb and into a puddle.
And while perhaps she may have deserved such treatment, the bouncer pointed out to the officer that the suspect was completely dry and had no physical manifestations of injury. During the entire time the officer was speaking with the bouncer, the suspect was yelling at the officer from the back seat of his patrol car.
She screamed at the officer, demanding that he call her mother. The 23-year-old suspect, who said she is a therapist, then went on to say the bartenders and bouncer threw her into a puddle and punched her.
Witnesses at the bar gave statements to police saying the woman was loud, drunk and tripped several times while walking around the bar, the report said.
One witness said she tried to open a closed door and when she did, she opened the door right into her own face.
While the officer was taking a statement from a witness the suspect screamed that they were liars and just jealous, the report stated.
She then implied, according to the police report, that the only reason the officer was taking witness statements was so that he could flirt with the girls in an attempt to take them home. If only it were that easy.
The officer then began the paperwork for her official arrest and the suspect began rolling around in the backseat, kicking the cages of the patrol car and attempting to get out of the car by pulling on the handles, the report said.
She continued to scream at all the witnesses and call them liars and jealous people.
Another officer arrived on-scene to transport the suspect to jail. He had another prisoner in his car as well. The report said that the suspect started to kick this male prisoner. That is when officers called for a transport van so the two could be separated.
She was booked and lodged and additionally charged with trespass notice from the bar.
A woman called police because her neighbor began yelling and screaming at her over her dogs.
She told the officer, according to the report, that she was in the backyard with her son feeding her dogs. She said her neighbor came outside and began yelling at her and beating on the fence that they shared between the yards.
The dog owner told police that her neighbor is obsessed with their dogs.
Upon speaking to the neighbor, the police report said they learned that this neighbor saw the two dogs attacking each other and she was screaming at them and hitting the fence to stop them from fighting.
She told police, according to the report, that she thinks the dogs are ill treated and are not fed properly or taken care of.
She said the dogs were fighting with each other because the dog owner had not fed them in the last two days and the dogs were fighting over food. The dog owner said she feeds the dogs twice a day.
The officers observed the dogs and according to their report, they appeared to be in good health and had food and water and a large shelter.
Police told both individuals to stay away from each other. The neighbor was told to call animal control if she had concerns about the dogs and not to take matters into her own hands.
(The Police Blotter is intended to be an informative and/or humorous column written from police reports obtained from the Mount Pleasant Police Department. Many of the stories come from the initial incident reports and, occasionally, supplemental reports. Generally, cases have not been adjudicated at the time of publication. See more columns at www.moultrienews.com.)
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As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
WaferGen Biosystems snagged an exclusive license from Rutgers University for an RNA quality control technology, which was developed at RUCDR Infinite Biologics under the leadership of Jay A. Tischfield, Ph.D., and Andrew I. Brooks, Ph.D. RUCDR Infinite Biologics is a Rutgers University-based cell and DNA repository.
The company intends to develop and commercialize products based on the patent's concept utilizing WaferGen's high-throughput qPCR SmartChip System.
"The accuracy and relevance of gene expression assays largely depend on the quality of the samples being analyzed. Unlike DNA, RNA is prone to rapid degradation which can lead to unreliable results that affect both research and clinical diagnostic data. Assessing the quality and integrity of RNA samples is of paramount importance prior to conducting experiments. Current QC methods use indirect measurements and lack the robustness and veracity needed to make conclusive assessments of the samples' quality. Our approach incorporates multiple tissue-dependent cDNA measurements and provides a much more stringent measure of sample quality as it pertains to downstream analyses. WaferGen's high-throughput qPCR platform allows us to implement our multianalyte solution in a rapid and cost-effective manner," said Dr. Tischfield, founder and CEO of RUCDR.
The SmartChip Real-Time PCR System is a next-generation genetic analysis platform for profiling and validating molecular biomarkers. According to WaferGen, it provides a range of high-throughput capabilities including microRNA and mRNA gene expression profiling as well as single-nucleotide polymorphism genotyping.
In April, WaferGen Biosystems embarked on a strategic realignment with the SmartChip at its core. The company's new focus is on accurate high-throughput qPCR projects for gene expression, genotyping, and target enrichment for next-generation sequencing in a simpler and more cost-effective way.
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on July 13, 2013 - 12:32 AM
Parking lots, environmental enhancements and façade renovations are all on the docket for consideration by the Buffalo Planning Board at its meeting next week.
McGuire Development Group is seeking approval for some exterior changes to its plan for the former Sheehan Memorial Hospital, now called Compass East. The developer wants to move some parking around and add some more green space, among other things, said President Jim Dentinger.
McGuire bought the 8.7-acre property out of bankruptcy late last year, and its $20 million project entails converting the 160,000-square-foot former hospital into a medical, technology and workforce facility.
Time Warner Cable Business Class will to locate its East Coast service center on the first floor, with more than 150 jobs, and the building will also house University Pediatric Dentistry and a McGuire Group training facility, as well as temporarily the Langston Hughes Institute.
Additionally, board members will consider a design and site plan to build a 31-space parking lot for D'Youville College at 783 Niagara St., which is a vacant, fenced-in lot at Vermont Street, about a block from the landlocked campus.
Buffalo Niagara Riverkeepers has applied for approval of its site plan to restore and enhance the Buffalo River shoreline to the west of the drawbridge at Riverbend Commerce Park, 1339 South Park Ave.
The Hatch restaurant, a mainstay of the waterfront for years, is seeking approval to construct two two-story additions.
And developer and Erie County Clerk Chris Jacobs – who owns Avalon Development – is seeking permission for $500,000 in upgrades and façade renovations for his Brownies Uniform Building at 739-741 Main St., for a new tenant, Avalon Document Services. The two firms are not related.
Avalon Document, which started in Utica and came to Western New York five years ago, is located down the street in 5,000 square feet at Jacobs' building at 721-723. But it needs more space, so it is relocating to the other building, which Jacobs has owned for five years. Jacobs said it will likely increase employment as well.
The new site is actually two structures – the two-story building on Main and an attached single-story back building that fronts on Washington Street.
Avalon Document will have 9,500 square feet for its office and production needs, and the back building – originally a car garage – will be converted to indoor parking for 15 cars.
The meeting is at 8:15 a.m. Tuesday in City Hall.
Separately, the city Zoning Board of Appeals will consider a variance request by David E. Pawlik of Creative Structures Services, who wants to build a two-story, eight-unit apartment building on a 4,720-square-foot fenced-in vacant lot at 2017 Bailey Ave., with parking at 222 Doat St.
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Lifestyle Calendar, June 20, 2012
admin | 6/21/2012, 5:30 a.m.
The Hadley Park Homeowners Association invites the community to their monthly meeting on Tuesday, June 26th at 6:30 p.m. at the Carrie P. Meek Arts Center, 1350 Northwest 50th Street in Miami, where they will be updated on current affairs in our community. For information, please contact Dr.Robert Malone at 786-512-51919. The Miami Chapter of Top Ladies of Distinction, Inc. and Top Teens of America's upcoming Scholarship Extravaganza will be held on June 30th at Jungle Island 9:30a.m. For tickets, call Lady Mary L. Walton at 305 635-0504. WIN (Women in NAACP) will hosttheir annual luncheon showcasing the 2012 ACTSO (Academic, Cultural, Technological and Scientific Olympic) winners on Saturday, June 23rd at 1p.m. at First Baptist Church of Bunche Park. 15700 N.W. 22nd Ave. in Miami Gardens. For tickets and information, please call Doris Harden 305-681-0457 or Robbie Hall 305-836-6682. The Ansha Group and Dj vu Theatre Production is hosting the original play, Divided We Fall, an adaption of the West Side Story, on July 21st at 4 p.m. at the African-American Research Library at 2650 Sistrunk Blvd in Ft. Lauderdale. RSVPs are required. For information, call954-557-7491 or 954-478-4883. Miami Northwestern Alumni Classes are hosting their annual Blue and Gold Dance at the Hialeah Race Track, 2200 E. 4th Avenue in Hialeah on July 7th, 8 p.m. 2 a.m. For tickets and additional information, please call John L. Cheever at 305-693-1513. The Opa-Locka Panthers spring cheerleader camp at Ingraham Park, at 2100 Burlington Street, begins May 22 - June 7th, 6 - 8 p.m. For more information contact coach Keisha at 305-318-3876 or Mashanda at 305-318-2213. Miami Rescue Mission is hosting their fourth annual Alumni Picnic at Crandon Park Beach, 6747 Crandon Blvd in Key Biscayne, on June 16th, 8 a.m. - 4 p.m. Youth Education and Athletic Program (YEAP) Summer camp June 11th - August 10th, Monday-Friday,7 a.m. - 6 p.m. For more information call 305-454-9546. Merry Poppins Daycare/Kindergarten will have open enrollment for VPK class now and summer camp June 11th- August 17th. For information call Ruby White or Lakeysha Anderson at 305-693-1008. Urban Partnership Drug Free Community Coalition monthly meeting will be held on Thursday, June 21st at the Jessie Trice Family Health Center, 5607 N.W. 27th Ave. from 10 a.m. - 11:30 a.m.Miami Central High School Class of 1992 is celebrating their 20-year reunion June 22nd - June 24th. For information contact 786-258-3450 or email firstname.lastname@example.com Northwestern Class of 72 presents an Old School Dance on June 22nd, 8 p.m. -1 a.m. at the Sheraton Ft. Lauderdale Airport Hotel-1825 Griffin Rd, Dania. For more information contact Don Williams at 954-376-0656 or Rosylen Sutton-Cox at 786-390-7478. Booker T. Washingtons 1962 Alumni Class is planning their 50th reunion June 24th- July 1st. All are invited to upcoming meetings held every month at the African Heritage Cultural Center, 6161 NW 22 Ave. For more information, contact Helen Tharpes Bonaparte 305-691-1333 or Lonzie Nichols 305-835-6588. Miami Alumni Chapter Tennessee State University will hold its monthly meeting at 6:30 p. m. on Friday, June 29th at the Omega Activity Center 15600 N.W.42nd Ave. A free fish fry will be a part of the meeting and all TSU graduates and friends are invited. For information contact Charles C. Stafford at 305-624-3663. Northwestern Alumni Scholarship Fund-Raiser presents live entertainment at Happy Hour, 6 - 9 p.m. at Legends Cafe 2029 Harrison in Hollywood every first Friday ofthe month beginning June 1st. For information contact John Rick Ziegler at 305-332-7534. Miami Northwestern Senior High Class of 1973 will meet the 3rd Sunday of each month. We are planning our 40th reunion in 2013. For more information, contact Gloria 305-635-3015 or Louise 305-215-3911. The Miami Northwestern Class of 1967 meets on the 2nd Wednesday of the month at7 p.m. at the home of Queen Hall 870 NW 168th Drive. We are planning our 45th reunion.Call Elaine at 786 227-7397 or www.northwesternclassof67.com.Booker T. Washington Class of 1967 meets the 3rd Saturday of each month at the African Heritage Cultural Arts Center. For information contact Lucius King at 305-333-7128. The National Coalition of 100 Black Women Greater Miami Chapter is accepting applications for girls ages 12-18 to participate in Just Us Girls Mentoring Program. Monthly sessions will be held every 3rdSaturdayat the Carrie Meek Center at Hadley Park. Call 800-658-1292 for information. The Miami-Dade Democratic Party will be hosting an Independence Day Celebration and Voter Registration Drive on Wednesday, July 4th 11a.m. - 3p.m., at Legion Memorial Park, 6447 NE 7th Ave. Admission is free and open to all. For more information, contact (305) 477-4994. The Oldtimers of Miami are sponsoring their Annual Fun Trip to historic Savannah, Georgia , July 16- 20. For more information call John Williams, 305-626-7500 or 786-423-4834 American Senior High Alumni Association is hosting a masquerade ball, "An Evening of Fun and Fantasy" on July 27th at the Hillcrest Country Club. For information call 305-458-4436. New Beginning Baptist Church of Deliverance of All Nations invites you to weight loss classes the 1st and 3rd Saturday of every month. Call Sister McDonald at 786-499-2896. Range Park is offering free self-defense/karate classes for children and adults each Monday and Wednesday from 6 - 8 p.m. The location is 525 N.W. 62nd Street. For more information call 305-757-7961 or contact Clayton Powell at 786-306-6442. Chai Community Services food program is taking applications from low-income families and veterans. All services are free. For applications call 305-830-1869. Dads for Justice, a program under Chai Community Services, assists non-custodial parents through Miami-Dade State Attorney's Office with child support modifications and visitation rights. For information call 305-830-1923. Jewels Baton Twirling Academy is now accepting registration for the 2012 season. Open to those who attend any elementary schools within the 33147, 33142, 33150 zip codes and actively attend church. Contact Elder Tanya Jackson at 786-357-4939 to sign up. Resources for Veterans Sacred Trust offers affordable and supporting housing assistance, family resiliency training and other resources for low-income veteran families facing homelessness or challenges maintaining housing stability in Broward and Dade counties. Call 855-778-3411 or visit www.411Veterans.com for more information. Solid Rock Enterprise, Inc. Restorative Justice Academy offers free consultation if your child is experiencing problems with bullies, fighting, disruptive school behaviors sibling conflicts and/or poor academic performance. For information call 786-488-4792 or visit www.solidrockent.orgMiami-Dade County Community Action & Human Services Head Start/Early Head Start Open Enrollment Campaign for free comprehensive child care is underway for pregnant women and children ages 2 months to 5 years of age residing in Miami-Dade County. Applications and a list of Head Start Centers are available at www.miamidade.gov/cahs or call 786 469-4622. Looking for all Evans County High School Alumni to create a South Florida Alumni contact roster. If you attended or graduated from Evans County High School in Claxton, Georgia, contact 305-829-1345 or 786-514-4912 S.A.V. (Survivors Against Violence) is a Bible-based program for young people and meets at Betty T. Ferguson Center in Miami Gardens each week. For info call Minister Eric Robinson at 954-548-4323 or www.savingfamilies.webs.com. Empowerment Tutoring in Miami Gardens offers free tutoring with trained teachers. For information call 305-654-7251. A local softball team for healthy ladies who are 50+ years old is ready to start and only needs 15 more players. Many different experience levels are welcome. For information, call Coach Rozier at 305-389-0288 or Gloria at 305-688-3322. Looking for all former Montanari employees to get reacquainted. Meetings are held on the last Saturday of each month at 9 a.m. For information contact Loletta Forbes at 786-593-9687 or Elijah Lewis at 305-469-7735. Miami Jackson and Miami Northwestern Alumni Associations are calling all former basketball players and cheerleaders for the upcoming2012 Alumni Charity Basketball game.Generals call 786-419-5805, Bulls call 786-873-5992, for information. Miami Jackson Senior Highclass of 92 is currently planning a 20th year reunion. Call committee president Herbert Roach at email@example.com. The 5000 Role Models of Excellence Project will be celebrating 20 years of mentorship at their 2013 5000 Role Models Reunion. All role models members, mentors and students are urged to contact the Role Modelss office by e-mail: email@example.com or call 305-995-2451ext. 2. The Expert Resource Community Center (HUD approved Counseling Agency) located at 610 NW 183 Street, Suite 202, Miami Gardens, every Wednesday at 9:30 a.m.- 11:30 a.m. For more information call Lou Green at 305-652-7616.


text:
on January 2, 2013 - 9:38 PM
, updated January 3, 2013 at 5:20 PM
A decision to circumvent typical bidding procedures for a major county project to reconstruct Eden-Evans Center Road in 2011 made it susceptible to "favoritism," county auditors have found.
Auditors in the County Comptroller's Office faulted the Department of Public Works for choosing contractors for the first two phases of the $7.7 million project through a pre-approved list of vendors, rather than by formally requesting proposals for the entire project.
"Bypassing DPW's normal bidding practice allows management the opportunity to practice favoritism in selecting vendors for projects," auditors warned.
The audit – released by outgoing County Comptroller David Shenk on Monday before his term ended – examined the way the county's Department of Public Works selected contractors and vendors for the project to reconstruct 6.6 miles of Eden-Evans Center Road.
The county in 2011 selected contractors for the project from a pre-approved "Highway Bid Book," which is typically used for smaller road work and emergency repairs. Contractors on the list submit bids annually to supply construction and maintenance materials throughout the summer construction season.
None of the 10 other large capital projects started that year by the Public Works Department used the bid book to select contractors.
"During some of our audit interviews, key DPW personnel stated that they were not aware of any capital projects similar to the magnitude of Eden-Evans that used the Highway Bid Book in lieu of the bid process," auditors stated.
Five contractors – All American Companies of Western New York, Amherst Paving, Country Line Stone Co., Gernatt Asphalt Production and Union Concrete & Construction Corp. – provided the bulk of the work and supplies under the first two phases of the project.
The auditors criticized the county for "improperly" using the bid book for such a large project because there are no written guidelines or procedures for the department's use of the pre-approved bid list. County law allows purchases to be made in that way when the county executive declares a public emergency, but auditors found that then-County Executive Chris Collins had not made that declaration.
The decision to use the bid book for the Eden-Evans Center Road project was made in 2011, when Gerard Sentz was commissioner of public works. Sentz was replaced in early 2012 when County Executive Mark C. Poloncarz took office.
The Buffalo Building and Construction Trades Council filed a lawsuit in State Supreme Court in September 2011 over the county's failure to bid out the entire Eden-Evans Center Road project. The lawsuit was withdrawn after Poloncarz took office and "made a commitment to bid out subsequent phases of the project" and all county public work over $35,000 in accordance with the state's competitive bidding laws, said attorney Anna Falicov..
A contractor for the third phase of the project in 2012 was selected through a competitive "request for proposals" process. Accadia Site Contracting was selected from eight bidders for a $2.9 million contract for the third phase, said Peter Anderson, a spokesman for Poloncarz.
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LC-MS Gains Favor Due To the...
Expanding Use of NGS Has Largely...
As Immunotherapy Revolutionizes the Cancer Treatment...
Wall Street Decline Takes Its Toll...
Across-the-board cuts in the federal budget or "sequestration"—the first installment of which is expected to be carried out today absent a deal on federal spending—will have a "substantial" impact on their research, with grave consequences for the future of the nation's biological and medical research efforts, more than two-thirds of scientists agreed in a newly released poll.
In a survey of U.S. academic, government, and pharmaceutical scientists by the life sciences research and advisory firm BioInformatics, 69% anticipate the cutbacks will limit their ability to hire new staff for their labs, obtain new grants, and attend scientific conferences. That is, 69% gave answers on a 0–10 scale of 8 to 10 when asked how much of an impact they thought sequestration would have in their work, with one-third (33%) saying it rated a 10 in terms of substantial impact.
The percentage was even higher among academic and government researchers (75%) though not among researchers at biopharma companies, only 42% of which agreed. Who was questioned may explain that difference: Academic or university scientists accounted for more than half (56%) of the 320 scientists who responded to the survey. The next two largest groups of respondents were government scientists (10%), and biopharmaceutical company scientists (9%).
"I don't think anyone in academia is demanding they receive carte blanche," BioInformatics President Bill Kelly told GEN this morning. "They understand budgets are limited. But what they don't want to see is this starting and stopping of budgets. Science is a long-term investment. It needs to be funded consistently over time, because inconsistency and uncertainty drive people away from the field."
As for industry, he added: "Our hypothesis was those scientists in pharma who said there would be an impact to their work were probably thinking more long-term," since academia trains future scientists and the effects of a slowdown would take time to be seen by industry.
Other industry scientists seeing an impact from sequestration, he said, are those working in government-sponsored clinical trials or startup biotechs that benefit from non-NIH federal funding, such as the recently renewed Small Business Innovation Research program.
The survey also found that academic and government scientists have both reduced their average annual operational research budgets this fiscal year compared with FY 2012—down 2.9% for government, to $369,717, and down 1.3% for academic labs, to $235,954. Industry lab budgets, however, will rise 1.5%, to an average $623,019.
Kelly said those cutbacks were not in anticipation of sequestration, but of the continued steady budgets that NIH has seen in recent years. "There were a number of comments that said, 'We've already halted travel. We've already cutting back on purchases. We already have a hiring freeze.'"
"In figuring out their budgets for 2013, they were already anticipating a flat funding environment. There was a lot of budget uncertainty to begin with," given talk of sequestration since it was included as part of the Budget Control Act of 2011. That law requires President Obama and Congress to agree on how to cut $1.2 trillion over 10 years, or else carry out sequestration.
For all surveyed, about half their annual research budgets are funded through federal government grants (48.6%), with departmental funds a distant second (14.6%), and corporate R&D funds an even smaller share (9.8%).
Interestingly, grants from private foundations or charities accounted for 5.5% of budgets. It's too soon to say if that percentage will rise as a result of sequestration, Kelly said, since it's not known whether those groups will be able to, or willing to, fill the funding gap left by reduced federal spending.
While decrying the likely effects of sequestration and voicing support for more research funding, several academic researchers said the cuts should also be coupled with spending reforms by NIH; the agencies could save a significant amount of waste by updating their computer systems, holding grant reviews by videoconference, encouraging more interdisciplinary collaboration, and targeting more funding to younger researchers and projects deemed innovative.
"In the academic community, there's a sense that the grant process could be reformed to make it more fair, and we received comments that it could be reformed to make the process more efficient, more streamlined, and be able to put research dollars into more hands," Kelly said.
The survey demographics may account for another finding, one that suggests sequestration's effects may not be as bad for life sciences tools companies. While they can expect lower sales as a near-term reaction to the federal budget cuts, only one-quarter of academic and government life science labs said they will consider deferring or postponing capital equipment and/or instrument purchases in 2013, the survey also showed.
"It appears what they're going to do is cut back on those things that are discretionary expenses: There may be conference people don't need to travel to. They'll institute hiring freezes," Kelly said. "They'll do all sorts of things in order to preserve the research that they're currently conducting, and it's likely most of their 2013 grants and/or operating budgets are funded for the remainder of the fiscal year. The bigger concern comes in 2014 if funding is not restored."
The survey's full results can be found here.
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WEIRTON - Though it started slow, the No. 3 team in the West Virginia Class AA-A boys soccer rankings, Weir High, came away with tough 2-0 win over Hancock County rival Oak Glen Tuesday at Jimmy Carey Stadium.
"Our coaching staff is very proud of this team," said Weir head coach Joe Pepe. "This team is very good on and off the field. You can't take anything away from Oak Glen. Being a county rival, they always come down and play their best game against us.
"You have to give them credit. They didn't quit. They kept the pressure on, but in the second half we did take control."
Article Photos
Oak Glen's Travis Bolner kicks the ball as Weir's Jonathan Fedoush defends Tuesday at Jimmy Carey Stadium. (Photo by Fred Younce)
For a majority of the first half the Golden Bears controlled the ball, won most 50-50 balls, and kept the Red Riders on their heels.
Despite that fact, Weir was able to grab a lead just three minutes and seven seconds into the game on one of their few first half opportunities. Shane Davis sent a beautiful pass through to Kenny Muhart who sent a shot from about 11-yards out past Oak Glen goalie Nick Fryer for the early 1-0 lead.
The Golden Bears went on to control the majority of the remainder of the first half, but were unsuccessful in putting the ball past Weir goalie Matt Tenaglio.
"I'm very proud of these boys everyday," said Oak Glen head coach Aaron Bennett. "They give me everything they got, and we're trying to learn a new style. I'm making them pass, we're looking like a soccer team, and it's nice."
The second half looked entirely different, yet the result was the same with Weir scoring one to Oak Glen's zero.
The Red Riders came out with a fire in the second half, no longer being beaten to 50-50 balls, and making crisp passes.
"We came out a little flat," said Pepe of the first half. "We have a lot laying on the line here. We had a nice talk at halftime. They came out in the second half and played a little better."
They only came away with one more goal in the half, but it was enough to ice the game as the Golden Bears didn't offer much of a threat after intermission.
At the 29:22 mark Muhart returned the favor, assisting on a Davis goal. The scoring opportunity was set up when Ryan Duke won the ball with a header off an Oak Glen goal kick that went to Muhart who left the ball for Davis for the score.
"We had to start winning those balls, and we had to start playing our game," said Pepe of Duke's header. "These kids know what they have to do. We tell them the glass of water to us is always half full, and we're always ready to go."
Weir closed things out from there to move to 9-1-1.
"We're a good team on our way to being a great team," said Pepe. "We have to take one game at a time. We're 9-1-1, these kids, if the calculations are right, won Class 4A of the OVAC for the seventh or eight straight time, and about nine total.
"Hopefully we get the No. 1 seed in our section, and sit back and see how everything else pans out with the tournament."
Both keepers played strong with Tenaglio saving eight shots for the shut out and Fryer turning away 10 shots.
Weir and Oak Glen take to the field again Saturday with the Red Riders traveling to Parkersburg South and the Golden Bears hosting Jefferson County Christian School.
"Now we travel down to Parkersburg South, and they've won six or seven matches already," said Pepe. "They're a big AAA school, so we'll see how we pan out here Saturday against them."
Added Bennett, "Right now I'm just looking for a break for my team to get healthy. We know what Weir High has. We know we were going to come in and it was going to be a tough game.
"Every year they're good. Just plain, straight out, they're good. We just played last night at Indian Creek, we're beat up, and we were beat up before that.
"Nothing against those guys, they did exactly what they needed to do. That's a good team form Weir."


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DIY Wedding
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Garden Flowers: Thank You Note
By: Arnold Grummer's
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Looking for some great ideas for a crafty, handmade wedding? The Garden Flowers collection from Arnold Grummer's Paper Making Kits and Supplies is simple and elegant -- perfect for an outdoor ceremony. Follow these steps for gorgeous Thank You Notes from recycled paper.
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- Handmade paper: 1 1/2" x 1 3/4"
- Cardstock: 5 1/2" x 8 1/2"
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- Glue
- Envelope: Size A2 (4 3/8" x 5 3/4")
- See 'Garden Flowers Invitation.' Follow steps 1 through 5.
- Print cardstock using your home computer. Leave a 2 1/4" space between 'THANK YOU' and the couple's names. Fold card in half.
- Layer handmade paper onto accent cardstock. Adhere with glue.
- Use hole punch. Make 2 holes, 3/4" apart, in the center of the paper piece.
- Lace ribbon: Down thru the left hole, up from back thru right, over and down thru left again, across and up from back thru right, leaving a 2 1/4" tail on both sides.
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