text:
How to get more kids to code
Open source programs to get more kids to code
At OSCON this year, Regina ten Bruggencate and Kim Spiritus gave a talk called How To Get More Kids To Code. I got in late (I was waiting in line to get a free signed copy of The Art of Community by Jono Bacon) so I missed the beginning of this session, but came in as they were demoing Scratch. This is a website where kids can play little games (available in 40 languages) and then click the 'See inside' button to see the code behind the game in a kid friendly way. It's a great way to get kids to see code and learn not just programming, but the concepts of open source.
Next up was Alice meant for kids ages 8 and up. This site uses a story telling type of learning to program. For some reason boys don't seem to like Alice very much (they're not really sure why since the kids can use aliens and spaceships in their stories). Using Alice you can drag and drop objects in to your scene/story and when you do it pops up windows where you enter properties for the items. Once you have your scene set up you can edit the code by clicking on the object (your alien for example), but the edit screen is not your standard 'code' view, instead it's friendly to kids by giving them pull down menus of actions.
Greenfoot is meant for slightly older kids (12+), but works similarly to Alice. The code editor in this shows you the Java with a bit of color coding (unlike the other tools that showed code in easy to use bubbles). Greenfoot is actually just a visual interface on top of BlueJ.
Another option is to use Mindstorms, which walks kids through creating a robot and programming the "brain." Mindstorms is great for kids age 8 and up.
Sagan is an open source project where you can simulate the Mars rover. It comes with three Mars landscapes and you program your rover to move around. It even has conversion tools so you can load it in to a Mindstorms robot (and others).
Arduino is a great way to teach kids about programming and electronics (and it's not only for kids!).
Raspberry Pi is a computer with a flash hard drive that will take any Linux distribution. I has two USB ports (keyboard and mouse), an ethernet port, and a port to connect to your TV. This is a great way to let the kids see the inside of the computer and work with it and programming on it. Quite a few people actually use this as a media center.
In addition to tools, there are events out there for kids. Devoxx 4 Kids is a one day convention with a keynote in the morning and parallel tracks during the day. In the sessions they learn about all of the tools listed above. The speakers are all computer professionals like us who want to get the kids involved. The first one in the Netherlands was sold out in two hours!!
Another initiative is the First Lego League which is a robotics project for kids. The kids have to create a Lego Mindstorms robot from scratch and then they have to share their solutions with the other teams (so a very open environment). There are competitions as well, but teams are not required to compete.
Maker Faire happens all around the world where kids can share what they have created—a place to share your love of science and building things.
VHTO is a program for girls in the Netherlands where kids can participate in different types of programs like Talent Watcher where they get to find where their talents lie. They also have a program called Mirror Image which shows them women in technical fields that they could participate in. Another program they offer is Speeddating where they get to decide if they want to go in to a more technical field than most girls might choose. They also have Girlsday where girls can visit the company to see what it's like to be in that field.
Originally posted on What I Learned Today. Reposted using Creative Commons.
11 Comments
Fantastic roundup, Nicole. The Sagan program will make a great addition to our astronomy and science courses.
There are some program dedicated to help women jump into the development side of free software:
Great article Nicole! I've been researching some of this stuff myself for some time now, and I hadn't even heard of a few of these.
We've built a prototype of a game called BotLogic.us and released it early August, and we've had a great response from parents and teachers so far (and even some adult players too). We wanted to make the game fun first so that players didn't necessarily realize they were learning fundamental concepts, and it's been great to watch kids as young as 4 (with some assistance) play the games too. Any help you could give us in getting the word out would be great too! One suggestion would be to support our Thunderclap Campaign, but that's just my shameless plug.
Thanks again for this article, I look forward to following up on some of these and maybe even one day teaming up with some of them to merge our robot logic programming game with real live robots! A guy can dream, right? :)
The OpenHatch project and its Open Source Comes to Campus outreach events are also excellent. https://openhatch.org/wiki/About_OpenHatch
Hi Nicole! I just sent my newest book for reviewing. In this book I explore the fact all of us are computer programmers and Scratch is one of the tools I cover. The book is in Portuguese and I do hope sometime I will have the opportunity to translate it into English. In the meantime, would you mind if I translate your post into Portuguese and publish it in my blog (http://dicas-l.com.br/brod)? Of course, I will maintain links to your writer profile and this wonderful original article. Thank you!
Hey Nicole, That's a nice collection of Opensource courseware for kids. We also include some innovative program for advanced coding. Find more details at http://www.fireboxtraining.com/java
really covering the all factors of kids code, and this one "First Lego League" that's hearing good..


text:
10 Stylish Diaper Bags That Don't Scream "Diaper Bag"Courtney Faith Vera
Parents with babies often feel forced to sacrifice style for function daily. As pretty as they are, many purses don't hold bottles, wipes or diapers — and don't even get us started on the stain risk you take by having your favorite bag near a baby.
My one rule when I became a mother 15 years ago was that my diaper bag will never even remotely resemble a diaper bag. People who know me will tell you — I don't do ugly. I'm not carrying some heavy, frumpy diaper bag. With all the options out there, especially with the eCommerce boom of the past two decades, you don't need to sacrifice style for functionality anymore. So, I set out on a search for a diaper bag that I could use from day to night.
After scouring all of the diaper bag styles: clutch, backpack, convertible, hobo, sling, messenger, tote, fashion, breast pump, and beyond, I found 10 stylish and functional ones that no one will even know hold the baby's dirty laundry (so to speak.)
Now when someone asks, "Where did you get your purse?" You can smile politely right on cue and say, "You mean my diaper bag?"
1. Elizabeth Leather Tan by StorkSak
This bag embodies sophistication and is structurally timeless. Celebrities love StorkSak as well. Angelina Jolie was keen on the Gigi (only available in the UK), but I've fancied the Elizabeth (seen here) since I saw it. It is made from lake washed leather, which ages with the bag and has brushed gold hardware. If you're looking for a diaper bag that doubles for office attire — most laptops fit inside this beautifully.
Available at StorkSak.com, $345.00.
2. Catherine Leather Almond by StorkSak
This diaper bag is my new favorite. I carry it everywhere and everyone thinks it's Marc Jacobs! This Hobo Style Diaper bag makes it easy to fall in love with the carrying your baby's accessories around.
Available at StorkSak.com, $450.00.
3. Be Right Back Tokidoki — Animalini by Ju-Ju-Be
This bag was stolen by my 16-year-old daughter upon seeing it. As in, I never actually got to use it myself. This animated backpack is the ultimate hybrid.
Available at Ju-Ju-Be.com, $148.00.
4. Mickey Mouse Diaper Bag by Babymel
Here is a classic example of how something can be printed all over a bag without appearing busy. Mickey Mouse is all smiles on this spacious satchel. It's so kid-friendly!
Available at DisneyStore.com, $62.96.
5. Zahra by Babymel
Available in teal or mustard, these bright colors make motherhood look fun, even if the rest of your outfit is comprised of yoga pants and your 7-year-old son's old Thor t-shirt.
Available at Babymel.com, $125.00.
6. Green Label Neckline Bag by Lassig
This diaper bag is unlike any other! It is unique, attractive and stylish enough to be used on a daily basis by mom long after the babies have grown. Best of all, it's lightweight and made almost entirely from recycled plastic bottles.
Available at HabaUSA.com, $169.99.
7. "Annie" Breast Pump Diaper Bag by Sara Wells
The "Annie" is the professional breast pump bag you've been waiting for. Stylish, functional, and tall enough to fit the largest laptops vertically, this bag will carry literally everything you need including the breast pump.
Available at Amazon.com, $165.00.
8. Brookside Tote by Little Unicorn
Available in three beautiful colors: blueberry, taupe and brown, this minimalist design and clean style is all about straightforward function. With eight pockets, a special protective iPad pocket, cushioned changing pads, matching stroller straps, handy key hook, and made of wipeable vegan leather, this bag is a must-have.
Available at LittleUnicorn.com, $75.00.
9. Kate by MZ Wallace
As women and moms, being prepared is non-negotiable. This bag was designed for a mom of triplets. It comes in two great colors: the Black Bedford and Redwood Bedford. Stylish and functional, this bag will last for years.
Available at MZWallace.com, $395.00.
10. Firenze by PacaPod
Designed by a clothing designer with two small girls, this bag is fit for royalty. Though designed for comfort and practicality, this style also appeals to the gap in the market for fashionable diaper bags. If you haven't heard about PacaPod or seen them yet, don't worry, they started in the UK. I'm sure they'll be internationally acclaimed soon!
Available at PacaPod.com, $520.00.
* * * *
Nothing says diaper bags have to be neutral, bulky or heavy anymore. You can have all the pockets you need, stylish hardware, and a fashionable diaper bag that you can carry from day to night.

subset: commoncrawl


text:
Celebrities who have been deported
POSTED: 06:08 AM PST Jan 30, 2014
Justin Bieber is only the latest celebrity to be facing deportation. Find out who's actually been kicked out of where.
The views expressed are not those of this company or its affiliated companies. Please note by clicking on "Post" you acknowledge that you have read the Terms Of Service and the comment you are posting is in compliance with such terms.blog comments powered by Disqus


text:
Non-Tender is the Night
As expected, the Cubs opted not to tender a 2010 Major League contract to LHP Neal Cotts, making Cotts a free-agenct. Cotts would have been eligible for salary arbitration if he had been tendered a contract, and could not have had his $1.1M 2009 salary cut by more than 20%. So Non-tendering Cotts will save the Cubs about $1M in 2010 payroll, and reduces the Cubs MLB Reserve List (40-man roster) to 37 players.
Cotts underwent "Tommy John" elbow surgery last July and has been rehabbing at Fitch Park for the past several months, so he might agree to sign a 2010 minor league ciontract with the Cubs so that he can continue his rehab uninterrupted at the same place and with the same training staff. It's unlikely that he would get a better deal elsewhere.
The Cubs did tender 2010 MLB contracts to their eight other arbitration-eligible players, as well as to all 19 of their pre-arbitration ("auto-renewal") guys.
Should a tendered player who is eligible for salary arbitration fail to reach agreement with his club on a 2010 contract, the player or the club can file for arbitration during a ten-day period beginning on January 5th.
Pre-arbitration ("auto-renewal") tendered players can have their contracts unilaterally and automatically renewed by their club if the player and the club have not reached agreement on a 2010 contract by the first week of March.
Here is the complete list of non-tendered players:
Brian Bass, RHP
Brian Anderson, OF
D.J. Carrasco, RHP
Adam Miller, RHP
Anthony Reyes, RHP
Jose Veras, RHP
Josh Anderson, C
John Buck, C
Jose Arrendondo, RHP
Matthew Brown, INF
Dustin Moseley, RHP
Chien-Ming Wang, RHP
OAKLAND A's
Jack Cust, 1B-DH
Ryan Langerhans, OF
Gabe Gross, OF
Shawn Riggans, C
Raul Chavez, C
Josh Whitesell, 1B
Ryan Church, OF
Kelly Johnson, 2B
Neal Cotts, LHP
Garrett Atkins, 3B
Jonny Gomes, OF
Alfredo Amezaga, IF-OF
Mark DiFelice, RHP
Seth McClung, RHP
Mike Rivera, C
Lance Broadway, RHP
Tim Redding, RHP
Jeremy Reed, OF
Cory Sullivan, OF
Clay Condrey, RHP
Matt Capps, RHP
Phil Dumatrait, LHP
Jackson Quezada, RHP
Mark Worrell, RHP
Ryan Garko, 1B
Mike MacDougal, RHP
Scott Olsen, LHP
Re: Non-Tender is the Night
How can a guy named Lance Broadway manage to get himself non tendered by the New York Metropolitans?
Re: Non-Tender is the Night
Are teams being more conservative in tendering players contracts this year? This list seems fairly long and full of relatively useful players.
I suddenly think I don't fully understand what it means to not be tendered a contract, but the Cubs need to be in on some of these guys if they hit the market, especially the pitchers (with bullpen and/or rotation spots to fill):
Capps, MacDougal, Olsen, McClung, Arrendondo, Carrasco.
And OF: Church, Sullivan, Gross.
Garko would make a really nice addition if the Cubs aren't confident in Hoffpauir, but I imagine he'll look for a larger role as a part-time 1B or DH. Cust would be even better as a PH 1B backup, but dreaming of that is absurd.
Some of these guys are seriously injured, right? Like Wang, he's gotta be out of the baseball picture for 2010, right?
I'm gonna go turn on my Playstation.
Re: Non-Tender is the Night
put me down for Matt Capps and burning a 40-man spot on Arredondo for 2010, wouldn't mind Johnson or Church but I don't see either happening.
Re: Non-Tender is the Night
Re: Non-Tender is the Night
Gotta figure why his BB/9 ballooned last year. No point in competing against Detroit, Baltimore, etc. to try to sign a guy who'll just have a 5.80 ERA again.
Re: Non-Tender is the Night
he had some injuries last year, a 2.82 BB/9 isn't bad...
obviously him being healthier would be paramount to signing him...
for the time being I've switched it so I have to approve new accounts, that should cut it down some.
There's a few other tricks past that if needed...
apologies for the hiccup, but at least I know where to get some cialis and kim kardashian porn now
Re: Non-Tender is the Night
Does most of this still originate in Eastern Europe?
Re: Non-Tender is the Night
whoa whoa, I missed the Kim K porn... repost that.
Seriously, another day of Cubbery (where Cubbery=nothing).
This is starting to suck, and I read somewhere (cubs.com?) JH talking about mid-February for things to take shape...
Cuz MB's value is just gonna skyrocket between now and then, just ask Bobby Abreu. Ugh.
Re: Non-Tender is the Night
Actually TONY S, I saw Hendry on CSN during the Winter Meeting exit, and he said - well he intimated - that he will hope for deals to get done "in the next ten days" before the Holidays."
As we are seeing, every day, every month, the MB "stock" becomes more and more devalued. This is not gonna end well and it is holding up any subsequent moves.
the best, and only positive I can say is that Hendry is cleaning up his own mess with the Aarons gone, Gregg, and trying everything to dump MB.
Re: Non-Tender is the Night
Thanks, E. It makes you wonder, was JH off his meds last year or something??
Re: Non-Tender is the Night
As we are seeing, every day, every month, the MB "stock" becomes more and more devalued. This is not gonna end well and it is holding up any subsequent moves.
This makes me want to keep MB. If Hendry reproduces last year's offseason of acquisition of talent I hope he never gets the opportunity.
Re: Non-Tender is the Night
Yeah, that's the kind of guy I always dreamed would be on our roster... a guy you can't pay someone to take.
Re: Non-Tender is the Night
"This makes me want to keep MB."
Well, with most "normal" players, a GM would do just that I'd think. While publicly many teammates say what a "great guy" MB is, privately I have heard the "beat guys" talk about how he is a "loner", "unapproachable", and more.
And, of course, he doesn't fit the "nice young man" image that is all things Cubbie.
Again, underlining the near-desperation level Hendry must have felt in order to have entertained ever signing MB in order to get more "left-handed".
I really thought that Hendry would have been gone after all of this, but, he gets a one-year reprieve imo.
Re: Non-Tender is the Night
Bradley is a cancer, and that cancer craeted havoc in the Cubs' $140 million team last year.
Cancers have to be removed, so even if it costs $8-9 million to do it, it's still a better option than having him damage another $140 investment in the 2010 team. As a practical matter, you simply can't allow a salary that equates to around 6% of your total payroll to bring down the whole team.
Hendry needs to bite the bullet, chalk it up to life experience, and move on.
Re: Non-Tender is the Night
How did Bradley cause poor years from Soriano and Soto, and injuries to Ramirez and Lilly?
My personal opinion is that the Cubs should just suck it up and play Bradley.
Re: Non-Tender is the Night
Bradley did not cause any bad seasons, or any injuries. He stunk on his own, plain and simple. Add to that his...interesting behavior? He's got to go.
Re: Non-Tender is the Night
Fair enough, but it seems to me that the best value the Cubs are likely to get for the $10 million they will be paying to Bradley next season is Bradley. I wish it were otherwise, but that doesn't appear to be so.
Re: Non-Tender is the Night
We paid some hefty change for a 40 RBI performance in an offensive position.
Just for comparision we paid league minimum for Jake Fox (44 RBI), Ryan Theriot (54 RBI), Mike Fontenot (43 RBI), and Geovony Soto (47 RBI) to drive in more runs than the great Milton Bradley.
An epic failure is an understatement for Bradley. His ass wasn't paid to underperform people with limited talents. And yet people try and spin it like he had a decent season.
He was the worst FA signing in baseball and among the worst OFers in baseball last year. But hell what do you expect from a guy who plays like and performs like a 4th OFer at best. 2009 is what you get.
Re: Non-Tender is the Night
Bradley didn't cause any of those injuries or slumps.
But he was a huge sisruption to team chemistry, and the players admitted after the season that one player could indeed have so much negative impact on a team.
There is an endless debate as to the correlation between "chemistry" and wins/losses. I am firmly in the camp that says that while winning can create good chemistry, bad chemistry can directly contribute to poor player performance and thus to poor team performance.
These players are together practically 24/7 for 8 months at a time. The Cubs' locker facilities are the smallest and most cramped in baseball, and the media attention here is intense. Thus, I think the Cubs need to be even more discerning of bringing in players who are not only excellent producers on the field, but also bring the off-field intangibles of leadership and positive team chemistry.
Re: Non-Tender is the Night
Bradley will never have less trade value than he has right now. These guys are supposed to be big leauers. I don't care if they don't love each other or even like each other. Put him out on the field. If Soto and Soriano hit,
a lot fewer people will notice Milton's problems. In fact, he might do better. If they don't, with Bradley or without, we'll still be mediocre. Why pay someone 12 mill so we can finish third. Sure it was a lousey signing but we have a history of lousey free agent signings. Buying our way out now just makes it worse.
Re: Non-Tender is the Night
the problem isn't the team...it's the fans.
more than the fans...it's how bradley reacts to the fans.
bradley put up great numbers at wrigley, but riding his ass was more fun to the fans (especially those with wal-mart posterboard) than what he was doing at wrigley. ...and of course, bradley lets this stuff get to him like it always has.
some people are more concerned with WWE-style drama rather than watching their team.
it's not his production teams are scared of...it's how bradley will interact with the fan base's expectations (and how they will return it) that scares a number of teams.
the bleacher bums can go drown in their $6 beers and hand out certificates to those throwing HR balls back...their culture means even less to me every year that passes. time to take off the Murton jerseys, guys. time to watch the game on the field, too, rather than planning an ambush on a guy who's an easy target just because it's fun.
Re: Non-Tender is the Night
Jacque Jones, Corey Patterson, LaTroy Hawkins, et al had the fans on their asses too. Worse than Bradley, from what I saw when I was in Wrigley this last year. The big difference to me is that Jones and company had teammates standing up to defend them. Even Captain Diplomacy Derrek Lee had turned on Bradley by the end of last season.
There's a lot more going on there than the fans getting under Bradley's skin.
Re: Non-Tender is the Night
don't forget Todd Hundley
Bradley's numbers were much better at home. He still only had 38 runs, 9HR and 28 RBI to go with .296/.407/.485.
Unfortunately, his road numbers of .214/.347/.299 were bad, with 23 runs, 3 HR, and 12 RBI.
So we could cheer him at home, but boo him on the road?
He's an easy target because he's an underperforming jackass, who's personality has made it hard, as a fan, to cheer for even when he's going well.
Re: Non-Tender is the Night
the fans were there to ride milton's ass...not watch the cubs.
ragging on bradley has been a fan-game before the cubs got him and it will probably continue. NY and BOS would eat him alive.
some people...a lot more than should...care more about getting under the skin of a professional than they care about rooting for their own team, if only for the moment. i find these fans totally useless whether it's their right or not.
why milton lets himself be a target? ...well, it's the same reason you have to spend more time with him and baby him (aka, manage him).
Re: Non-Tender is the Night
It's the same reason the Cubs shouldn't have signed him.
There are plenty of assholes that go to Cub games to drink and swear at players.
It's a shame this didn't work out better, but hopefully it'll be over soon.
If a player on the Cubs plays well, or does something deserving of it, I'll cheer loud and long for them. I'm not going to cheer for the bone headed, uninspired play of the Cubs of 2009.
Re: Non-Tender is the Night
they shouldn't have if they weren't ready to baby him. the guy requires a lot of work.
Re: Non-Tender is the Night
Ok..I guess what they really needed was to get Bradley a personal counselor, and someone to follow him around at all times to affirm what a great guy he is.
Re: Non-Tender is the Night
no one said he was great.
...people are saying that if you adopt a pitbull with an attitude problem you better have more forethought about your adoption that goes beyond "oh boy! it's a new doggie!"
Re: Non-Tender is the Night
Ok...fair enough crunch. I guess, in the end...Manny being Manny is accepted because he puts up HOF type numbers, while Milton being Milton is not, because he doesn't
It's a not so great chapter in Cub history.
Re: Non-Tender is the Night
i feel that 'manny being manny' works because he could care less what others try to rope him into. he gets his share of hell, but just does his thing and doesn't care.
for one reason or another milton doesn't have that filter which makes him a lot of work for a team to own to keep the guy on a level headspace.
Re: Non-Tender is the Night
the fans were there to ride milton's ass...not watch the cubs.
Huh? When's the last time you were actually in Wrigley? Bleacher fans are rowdier than other fans to be sure, but they don't buy tickets so they can play mind games with Cubs outfielders.
Hell, most games the right field bleacher crowd spends more time heckling the left field bleachers than they do the players on the field.
not ALL bleacher fans, but yes...there were plenty of camera mugging, posterboard pointing, milton-ass-riding people out there.
in NY (mets and yanks) the bleachers barely watch the game because they're too busy playing games rather than the game on the field. cubs are trying to catch up since the 00's it seems.
Re: Non-Tender is the Night
So your position is that fans can't get on Bradley for not doing well on the road, because he did well at home?
Re: Non-Tender is the Night
my point is getting on bradley has more to do with what the fan wants to get out of it for his/her own personal pleasure rather than any other reason.
bradley falls for it...these people love it. it's better than the game. the "posterboard people" were some pieces of work.
i'm not saying it's all fans...it wouldn't even matter if bradley wouldn't fall for it, but he does and he should have been managed accordingly rather than being left on his own to deal with it.
no matter who thinks bradley should man-up or whatever...get over it...he doesn't...you have to baby this guy. you have to have people willing to put in the extra work. it's pointless to put money into this guy if you're not willing to do so.
Re: Non-Tender is the Night
But you keep bringing up that he hit pretty well at home. He also threw the ball into the stands at home. A minor transgression, sure, but it's not a forgettable one given the rest of his issues.
Re: Clubhouse chemistry
from the same clubhouse/organization that said it needed someone with some fire and the guys were too nice in 2007 and 2008.
Re: Non-Tender is the Night
Fire is competitiveness....a hard slide into second to break up a double play...a fist pump after a game winning hit..firing up your teammates to come back to win a game you were losing. Fire is not calling out fans as rascists, hitting poorly, and fielding indifferently...bitching at reporters...etc.
Re: Non-Tender is the Night
I understand that point of view, but I don't think it's going to be as low as $8-9 million.
Bradley is owed $9M in 2010 and $12M in 2011. If he's traded and the Cubs pay all but $5M (rough figure) they will have $16M tied up just in Bradley.
If whoever they trade for has a salary higher than Bradley's 2010 we have to add the difference. We then still need to fill CF by signing Mike Cameron, which Hendry will do at above market rate, given his history. If 1/$7M is market value, Hendry could offer an extra year to make sure he gets him, a familiar tactic, and pay 2/$14.
If Hendry intends on flipping the Bradley trade partner, he may take on more salary. Let's assume it's Pat Burrell going to the Mets for Luis Castillo, who is owed $12M over the next two seasons. If the deal can be done straight up then we add $3M more to the equation.
Bradley =$16M
Cameron =$14M
Burrell = $0M
Castillo = $3M
Total = $33M
I know there's probably a million logical flaws in the above, but I can't quit dreading how Hendry will attempt to resolve this situation
Re: Non-Tender is the Night
Agreed Jimbo, if the Cubs can trade Bradley and get out from under most of his contract they should. Sadly, the market only seems to be interested in Bradley (for all of the reason pointed out in previous posts) if the Cubs pick up most of his salary.
It seems that the Cubs are left with deciding if they want to eat Bradley's contract or play him. Neither are good options, but with little increase in salary the likely performance you will get for Bradley IMO is better than a replacement level alternative.
Re: Non-Tender is the Night
The Cubs aren't going to pay $16 million of Bradley's salary. They're willing (rumored) to pay $5 million of his 2010 salary.
It's Bradley $5
Castillo $12
Cameron $14
Which comes to $31 million for two years of Castillo and Cameron.
Re: Non-Tender is the Night
If they pay $5M of MB's 2010 salary they'll be paying $14M. Close enough for me. I say let him roam the clubhouse and see if he can regain his best form and maybe we can build up his trade value a little bit before we dump him.
I'm sure it won't happen, but I hate to see the offseason crippled by the perception that he must go no matter the cost.
As much as selling low bothers me, it bothers me just as much that once we sell low we will proceed to overpay the likes of Cameron/Byrd/Ankiel because Hendry has thrown any leverage he had out the window. Fuck it. I'll watch the minors for another year and hope that the farm system will come to the rescue in another 2-3 years.
Re: Non-Tender is the Night
"even if it costs $8-9 million"
I think the Cubs would hand over Milton Bradley's contract plus $8 or 9 million to the first person who came in the door and asked for these things.
The numbers that are thrown around pertain to 2011, because the Cubs are usually accepting a contract like Burrell's for 2010. But 2010 will cost extra millions, too, since Burrell, like Bradley, is overpaid by a factor of 2 or 3, and unloading him will cost big bucks, maybe $6 million.
So now we're up to $14-15 million, and I still don't think anybody is coming through that door.
Re: Non-Tender is the Night
If you're pro Bradley and your argument is don't pay $10-15M to make him go away then that I understand. But don't tell us what a great run producer and offensive asset he is to a team.
In a 10 year MLB career with 7 teams, he averages 96 games and has never passed 77 RBIs. The piece of crap was brought here to be a run producing LH bat in the middle of the order. How'd that work out?
My point is that there is nothing in his past to indicate he'll ever be what Hendry hoped he would be. So color me in the 'goodbye Milton' camp rather than put up with 'the world hates Milton rag' for two more years.
Re: Non-Tender is the Night
Most reports I've seen assume that the Cubs would only have to eat $1-$2 million of Burrell's 2010 salary in order to flip him.
Of course, depending on which teams sign Bay and Holliday, that number could change drastically.
Re: Non-Tender is the Night
I'd like to see those reports--or any reports where they calculate the amount a player can command on the market today. What, for example, is Milton Bradley's value to a team--any team--today? I don't mean his statistical value--that will always make too big a deal about his OBP--but his value to real GMs and owners. In Bradley's case, the second year remaining on the contract drives his value way down, since you don't know which day THIS year you will feel the need to kick him off the team.
Take that number and subtract it from $21 million. That's what the Cubs will have to swallow.
To me, Adam Dunn is worth two Pat Burrells, unless you really, really want to be more right-handed. Burrell is owed $9 million, Dunn $12--but to the Nationals it feels more like $10, since the two years are backloaded and they just got a big year from him for $8. Half of $10 million is $5. But Burrell is three years older than Dunn. He probably can't go back to the national league. How many AL teams are there for which Burrell in left would be an upgrade?
If Burrell was easy to flip, why haven't the Rays flipped him? Why don't the Cubs just flip Bradley? I love that word, flip.
Re: Non-Tender is the Night
flip, flip, flipadelphia!
Re: Non-Tender is the Night
It's always sunny!
Re: Non-Tender is the Night
TEX about to finalize their m.lowell trade evidently.
hope they buy some duct tape and medical insurance.
Re: Non-Tender is the Night
The Rangers have the "next James Andrews" on their medical staff. A lot of injury-prone pitchers will probably start heading their way.
Re: Non-Tender is the Night
MLB Network classic games make winter a little more tolerable...just saying...
John Lackey
supposedly taking a physical for Boston Red Sox...
Re: Non-Tender is the Night
Must be nice. Since Ricketts, et. al. are so interested in modeling Boston, why not just get Theo Epstein too?
Recent comments
j.buchanan with a nice start...5ip 2h 1bb 3k, 0r/er
zobrist with 2HR and a double through 8
heyward 0-4 :(
Mark Gonzales @MDGonzales
Soler likely to return Sunday, Maddon says
Right now, I'd like to see the Mets first, Giants 2nd.
I believe that since most of the team from last years' NLCS is on the squad this year, they will really amp their game up even more to kick their ass in payback for 2015.
The Giants just do not have the depth in years past, and I think all things equal - and at Wrigley - they could handle them.
I do not want to see the Cards, period. Or their fans, media, or Joe Buck.
I don't want to play Braves in the first round. Any friggin team in the league can win 3 of 5..I hate the first round. Furthermore, I wanted to play the Marlins in 2003 and the Mets over Dodgers last year.
With that said in reverse order:
3. Cardinals: It will be devastating to lose in the first round, but even worse to their main rival. It is increased incentive for the Cardinals, especially after last year. Cards would have nothing to lose, Cubs have everything to lose.
2. Giants: Rotation in the playoffs scare me a bit, but what a lousy team.
1. Mets--because of the losses in the rotation
2. Giants--because they're not the team they were BUT they maybe have bullshit even-year magic?
3. Cardinals--because rivalry and not making the playoffs hurts them more than losing in the NLDS plus getting eliminated by them in the playoffs would make for horrible sports commentary next throughout next season.
Who's asking?
CLE/DET rained out last night already, possible rain-outs in New York (vs. Baltimore), Boston(vs. Toronto) and Philly(vs. Mets) this weekend too.
Not only games involving playoff spots that would need to be played, but any that involve home field advantage.
I got the first one! Second one I'm not even sure what even/odd betting is.
any opponent preference for NLDS?
Mets are down to 1 great pitcher instead of 4. Syndegaard may pitch Sunday which means if Mets win the WC game, he'd be set up for Game 1. There's a chance they clinch a spot by Sunday so he'd pitch the WC and then we'd probably get Colon for Game 1. They've certainly had the hottest bats over the last week and month out of the WC options.
A couple of Cub related puzzles.
Can't teach height and thinness
Hopefully Pirates don't call up A. Lincoln.
j.buchanan going friday...should be...baseball...or something like it.
Wow. I didn't know they could do that.
Nice for Willson, not so much for Addy.
Game is officially called...also officially a tie.
Stats count, no make-up date of course.
Yeah -- seeing the weather -- I hope KB and Rizz are inside, wrapped in blankets and drinking hot chocolate.


text:
Sources: Tech Crunch, Reuters, Reuters
quote: Just stop. It's so silly how you Apple people constantly need to marginalize, segregate, or outright discriminate people to make your points.
quote: Great endorsement you have there for the typical iPhone user's intelligence and knowledge of current events lol.
quote: Right, that's a pretty impressive statement considering Android outsells Apple handsets. I guess more people are "techie non normals" or whatever. It doesn't matter why, it only matters that they aren't choosing Apple.
quote: Most just buy a phone because they see an advert, the guy in the phone shop recommends it, they see a friend with it, it's the same brand they had before, it's cheaper.


text:
Wednesday, November 21, 2012
Thanksgiving is todaydoesnt it seem early this year? Or maybe that old adage is true: Once you pass 40, time moves at warp speed.
As you gather with your families to give thanks and break bread, I wish you health and happiness during the holidays and beyond.
I am grateful for so many things this year. As I count my blessings, some are positives and some are negatives. Youll see what I mean
Im thankful for:
Not having more aches and pains than I do. My feet are beat all to pieces from running, but my back is fine and my eyes arent too bad. (Which means, of course, that Ill be limping and squinting in a week.)
Cut-glass doorknobs.
The smell of fall.
My exasperating, hilarious 84-year-old mother. May she drive me crazy til shes 100.
My brothers, T-Bob and Bubba, who are everything Im not, thanks be to God.
My sister, Moonbeam, on whatever planet she inhabits these days.
Knockout roses.
The freshness of just-washed sheets and the delicious feel of feather pillows.
Friends both old and new.
Marriage to a brilliant, handsome, funny man, who knows all my quirks and loves me anyway. (Turns out normal people dont snack on mustard by the spoonful.)
Books, books and more books. Do not give me a Kindle for Christmas.
My perfectly imperfect body. Parts jiggle, wiggle and sag, but it does everything I ask it to do. An everyday miracle.
Cheaper gas.
The musical jingle of my dogs collar as she ambles merrily from room to room.
The freedom to do, say and be whatever I want as long as it doesnt break the law or frighten the goats.
Our armed forces. Self explanatory.
The good health of loved ones, including my 88-year-old mother-in-law, who is way sharper than her 51-year-old daughter-in-law.
Tolerance and forgiveness.
Modern Family, the best sitcom since M*A*S*H.
My inability to drive a stick-shift, because just trying to learn scared everybody stiff. If God wanted me to drive a five-speed, Hed have given me an extra foot.
The way my husbands eyes crinkle when he smiles.
Facebook, without which I would go crazy living in the boondocks.
The cozy creaks and groans our old house makes at night.
My belief that people are inherently good.
Coconut oil. You can cook with it AND use it as a moisturizer.
Church ladies who prepare delicious post-funeral receptions, teach Sunday school and coordinate food banks, asking nothing in return.
Old Navy jeans.
Flannery OConnor, Carson McCullers and Eudora Welty.
Everyone who puts on a uniform to fight fires, arrest bad guys and restart hearts.
Hot soup on a cold day.
Cold beer on a hot day.
Our inversion table. Apparently Ive been longing all my life to hang upside down.
A phone that actually keeps me from getting lost. Who knew?
The ability to run.
Comfortable running shoes.
Country roads to run on.
The kindness and generosity I see practiced around me daily.
My favorite snack: peanuts, Craisins and dark chocolate chips.
Good neighbors.
Scarves that A) keep my neck warm, and B) hide my neck. Win-win!
Our wonderful veterinarian, who prescribes pills for Nickys skin, pills for Nickys joints, pills for Nickys liver and pills for Nickys seizures. (Other than that, Nickys perfectly healthy.)
Stir-fried vegetables, pasta and my famous sugar-free oatmeal cookies.
Eyes that can see and ears that can (partially) hear.
Bubble baths.
The Weather Channel. Im obsessed.
Julie R. Smith, who is also thankful for newspapers and the people who read them, can be reached at firstname.lastname@example.com.
© 2016 The Gazette an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
Top Definition
Singer/Actor born 1974 in Ottawa, Canada.
Alanis Morissette is a cool Canadian chick.
লিখেছেন- fred savage 31 de জুলাই de 2004
Trending Now
Can you define these popular missing words?
a great singer from canada who sounds very good pissed off about her bf kicking her ass to the curb (see you oughtta know)
person 1: she just dumped me..
person 2: well your in a band, so just go all alanis morissette on her and write a kick ass song about how much she sucks.
person 2: well your in a band, so just go all alanis morissette on her and write a kick ass song about how much she sucks.
লিখেছেন- ocfangurl 17 de মার্চ de 2005
A Canadian singer who has a powerful singing voice and has written some pretty amazing songs. Her most well-known hit is 'Ironic' and the album people remember her by is 'Jagged Little Pill'. Shame really. I have 'The Collection' and there are some fantastic songs on that.
It's a shame people only remember Alanis Morissette for 'Ironic'
লিখেছেন- The-Movie-Goddess 16 de জানুয়ারি de 2007
reached the pinacle of success in her late teens in canada as a cheerful pop singer. Then Uncle Joey from Full House dumped her and she became all femanistic and reached global success in the mid 90's with her songs about angst.
Her pre-breakup songs were very bubblegum pop. Then she came out with songs like "You oughta know" and "Ironic."
লিখেছেন- coolkid4 28 de অগাস্ট de 2005
The greatest female singer ever!!!
I like the way Alanis morissette plays the harmonica and sings.
লিখেছেন- 3plus3equal6 6 de অগাস্ট de 2007
to suddenly change from happy-go-lucky and cheerful to moody and angst ridden. Often as a result of a breakup (such as Alanis Morisettes's with Dave Coulier)
Megan: NO, I don't want to go to the mall! I can't believe that stupid ass cheated on me. I don't think I'm ever going to be the same. I'm going to sit in my room and listen to angst-ridden music.
লিখেছেন- truthhh 28 de অগাস্ট de 2005
An amazing pop-rock singer, who is most well-known for her chart-topping album called Jagged Little Pill.
Alanis Morissette is amazing.
লিখেছেন- wingkon 7 de ডিসেম্বার de 2009


text:
Can Apple change education? | Opensource.com
Can Apple change education?
On January 19, Apple held a large, education-related event on in New York City. Just as with almost any other Apple event, pre-event speculations were all over the place. It was clear that the announcement was going to target the textbook market, but what wasn't clear was its scope. As AllThingsD's Peter Kafka wrote: "the key thing to watch at the Guggenheim is whether Cue brings up reps from the big textbook publishers like Pearson and McGraw-Hill onstage, or whether the focus is on letting educators and others build their own books, so they can bypass both the publishers and the antiquated textbook procurement system."
So what did Apple announce? Well, first of all, there's a new version of iBooks, Apple's e-reader application, which reads material from Apple's bookstore. iBooks has gotten a major overhaul and is now more interactive, supporting animations, models and videos, as well as featuring note-taking functionality. The bookstore itself introduces an new pricing policy: etextbooks are $15 or less, a fraction of what students currently pay for the newest editions of their current school books. And in fact, Apple partnered with Pearson, McGraw Hill, and Houghton Mifflin Harcourt (which together account for about 90% of all textbooks) to bring their textbooks to the online store.
Apple also announced the free iBooks Author app for Mac OS X: users will be able to create their own textbooks using a simple interface and can publish the resulting books to the store. In short, educators can create their own materials and make them easily available. In this way, Apple managed to come up with something for both large textbook publishers and individual educators.
Apple also announced a revamped version of iTunes U which previously served as a portal to aggregate podcasts and recordings of university classes and lectures, somewhat comparable to MIT's Open Courseware. The new version features a much more comprehensive approach, including everything to course syllabi.
But where's the catch? These changes are undeniably huge: the fact that the publishers were willing to crack down on their pricing for ebooks, which were previously priced similarly to the actual paper copies is a first. However, there are also a number of concerns, in particular around iBooks Author. Obviously, it's a Mac OS X-only application right now, making it difficult for Linux or Windows users to join the fun. That might not be a big issue for Apple, given that it succeeded building its iOS ecosystem while still requiring a heavy investment in Apple's hardware and software (while it might be possible to build iOS apps on other platforms, Xcode is OS X only).
Similarly, soon after the event, concerns about the application's EULA surfaced. Steve Kovach wrote for BusinessInsider, "Apple's End User License Agreement (EULA) states that books made with the iBook Author app and sold through the iBook store can't be sold anywhere else. However, if you offer your book for free in the iBooks store, then you can distribute it for free anywhere else you want."
Again, to some extent, this is the way it has been: either you purchase an expensive publishing application and get to choose where to publish your content, or you use a simpler and cheaper application to author it but risk being restricted to a certain store. But just because it's always been this way doesn't mean that it needs to continue. Locking users into the bookstore is certainly not in the spirit of the open source way. If you add in the fact that it is currently not clear whether other platforms will be able to access books from Apple's store, it's easy to see that the announcement creates more of a walled garden than an open community.
This move does make sense for Apple: making a wide range of high-quality textbooks available and enabling users to add their own increases the quality of content available on the iPad (and other Apple devices). But that doesn't mean that everyone has or is going to have an iPad, particularly in less well equipped schools (as ZDNet fittingly points out in its story about winners and losers of the announcement). Surely there will be discounts attached to large scale deployments, as Apple is likely going to be willing to pay a price to get into the market. But that doesn't make it accessible for everyone. So will this move create a bigger gaps between the haves and have-nots?
I agree with SlashGear's Philip Berne that "the problem with education is, and always will be, a human issue." Education is not a technology problem. So while technology may help reduce or overcome education's problems, it's not going to fix it. Or, as OLPC put it in its mission statement, "it's an education project, not a laptop project". And that's one of my main takeaways from the announcement: In the end, this move may revolutionize education. But it isn't going to fix it. That's a far bigger and deeper problem.
6 Comments
No, no, no and no.
Nothing like having a book in your hands and smell and feel each sheet of paper.
That's the best way to learn.
Under this logic I think Apple has nothing new to offer.
A $15 text now costs $514. Where is the savings? Some of these new books are a gigabyte in size. 16 books on an iPad for $499. No savings here, but all the Apple fans and bandwagon folks are all over these devices. Open educational resources, traditional books, and epublishing with companies like LuLu.com will revolutionize.
I have read many many postings applauding this move from Apple. Do people not realize that the schools that $15 texts could help are the same ones that can't afford to buy iPads? Even if the books were FREE, the cost of the iPad outpaces the cost of books. Remember, iPads have non replaceable batteries. Batteries last 2-3 years at most.
Great article this morning on ZDNet about the true costs of the Apple venture. Textbook of the Future: The Challenges, http://goo.gl/I1rUi
Another interesting article on ZDNet about How Apple is sabotaging an open standard for digital books
Are you all even college? The amount of money spent at a 4 year university (I'm currently in my spring semester of my sophomore year at Indiana University) on textbooks is unreal. My books from just my first two semesters combined cost more than an iPad. So no-I'm not spending 15 dollars on a textbook, I'm spending hundreds on a textbook (that's no exaggeration).
And there is such thing as iCloud. You don't have to store every gig of textbook on a device.
I'm all for open and free knowledge, but that does not seem to be happening in the near future. Apple may not be making it free-but at least they're opening the eyes to people that changes need to be made. Until then, I DO applaud this idea. Not saying I'll be purchasing an iPad because I prefer a book in my hand, but the iPad has already made its way into lecture halls.
P.S. definitely agreed..it's a human issue.


text:
The sweet farmer from Iowa attended the taping of After the Final Rose, and though it was announced a new bachelor wouldn't be revealed, Soules – who was let go by Andi Dorfman two weeks ago – turned bright red and laughed nervously when the discussion launched.
Fans would certainly be happy if he's indeed snagged the spot. The soft-spoken contestant won over hearts when he was revealed as Dorfman's secret admirer throughout the season and further stepped up the romance game by telling her he was in love by hiring a plane to fly over his hometown date.
"From an emotional perspective, it was tough going through the process and falling in love with Andi and not having it work out, but I'm strong and I've been there before and I'm going to figure it out," he told PEOPLE at the Men Tell All taping. "I'm optimistic that my future is bright and I'm definitely ready to move on."
He's also got Dorfman's seal of approval. "I mean, look at him," she said, laughing. "Chris has the whole package. He is the all-American guy who is a farmer who does not look like a farmer, but he's also successful and he's ready for a family. He's going to be a great husband and a great father."
Check back Tuesday for exclusive details on the engagement ring, as well as interviews with Josh and Nick, and of course, Andi's PEOPLE.com blog. For exclusive photos and an interview with the couple, pick up this week's issue of PEOPLE, on newsstands Friday


text:
Source: The Guardian
quote: It's up to the retailers to make it easy enough for the "dumb" masses.
quote: You think those services are offered to technology geeks?
quote: Your post is even more useless than mine then since all you're doing is telling me how useless my post is.
quote: I completely disagree. No matter how you cut it, there are a lot of variables that go into building a PC.
quote: OR I explained why it's not as simple and cut-and-dry as you suggest.
quote: Learn how to parse information and you'll have a lot less difficulty with basic communication, my hasty friend.
quote: Know your audience. Your entire post is preaching to the choir. People posting regularly to a tech site like this are well aware of both the How-tos as well as the relative cost/benefits of building one's own PC.
quote: But to the average consumer, you lost them with the very first sentence. Lists of parts is a further deterrent. Worst of all, you mention Linux.
quote: No, you're simply explaining why "people who understand and follow hardware" will always build their own PC's. It just simply is NOT an attractive option to the average gamer.
quote: I pretty much stated the opposite, so I don't know how this notion could have entered into your head.


text:
Author(s): W. Bensinger, M. Wang, R. Z. Orlowski, M. Alsina, T. Martin, S. Singhal, N. Y. Gabrail, M. Vallone, M. Kauffman, R. Niesvizky
Background: CFZ, a specific, irreversible proteasome inhibitor, is highly active with a favorable side effect profile in R/R MM. This open-label, phase Ib dose-escalation study evaluated the safety and maximum recommended dose of CFZ + LEN+ low-dose Dex, (CRd).
Methods: Eligible patients (pts) included those with relapsed or progressive MM after 1-3 prior therapies. CRd was given on 28 day cycles (C) in 6 cohorts as shown in the Table. Primary endpoints included safety and establishment of the maximum recommended dose. Other endpoints included overall response rate (ORR) and clinical benefit response (CBR).
Results: To date, 40 pts were enrolled in cohorts 1-6 and 27 in a cohort 6 expansion. 27/32 pts in cohorts 1-5 were evaluable for safety and 29/32 for response. Pts were heavily pretreated; 72% received prior BTZ and 87.5% received prior IMiD. 47% of pts were refractory to their last therapy; 84% had a history of neuropathy (67% related to prior BTZ or thalidomide). No treatment emergent fatigue, neuropathy, or thrombotic events ≥ Grade (G) 3 were observed. Hematological AEs ≥G3 (thrombocytopenia [n=6], anemia [n=4], and neutropenia [n=6]) were reversible. 4 pts had drug-related SAEs (transient G3 sinus bradycardia, G3 upper respiratory tract infection, febrile neutropenia, and G3 diarrhea + G3 urinary infection). ORR and CBR for 29 evaluable pts are 59% and 72%, respectively which included 21% CR/nCR, 17% VGPR, and 21% PR. Initial responses improved with continued therapy, up to 18 C. 43/67 pts remain on study. No dose- limiting toxicities or deaths have been reported.
Conclusions: CRd is well-tolerated in pts with R/R MM, even in those with a history of neuropathy. Nonoverlapping toxicity profiles of CFZ and LEN allow their combination at full doses for extended durations up to 18 C. Prior therapy with either BTZ or an IMiD, or disease refractory to the immediately preceding regimen does not preclude achieving MR, PR, VGPR or CR to CRd. Authors wish to acknowledge support from Celgene Corp.


text:
MACHESNEY PARK — The Harlem Community Center, 900 Roosevelt Road, will host its second annual Mother-Daughter Christmas Tea from 1 to 3 p.m. Dec. 1.
Moms and daughters of all ages will enjoy the Harlem High School Chorus, coffee, tea, shopping and a photo shoot. All daughters are asked to bring a minimum of one can of non-perishable food to donate to local food pantries. Reservations are encouraged.
Cost: $10, $3 for daughters without food donation. For information or reservations: 815-633-5817.
Location, ST | website.com


text:
Top Definition
When you have an empty box of beer on both feet (usually 24 packs, but dirty 30's work well too)You must drink at least 12 beers from either of the two boxes, otherwise you are not allowed to wear brew boots.
Yo dude, you see Tim? He is rockin' the Brew Boots tonight. Nice choice.
dodane przez Wild Tim marzec 22, 2006
Trending Now
Can you define these popular missing words?


text:
Serves 5 |
Prep Time 20 minutes |
Cook Time 1 hour 15 minutes
1/2 cup Eden Dry Lentils
6 cups water
1 clove garlic, minced
1/2 cup diced onions
1/4 cup diced celery
1/4 cup diced carrots
1 whole dried bay leaf
1 tsp Eden Sea Salt
1/2 cup Eden Ditalini
1/4 cup sweet corn, fresh or frozen
1/2 cup chopped spinach, fresh or frozen
2 Tbsp fresh minced parsley
ace the first seven ingredients in a heavy pot, bring to a boil, cover, reduce flame to medium low, and simmer approximately 1 hour or until tender. Add sea salt and ditalini. Simmer uncovered about 10 minutes. Remove bay leaf and discard. Mix in spinach and parsley, cook 2 minutes and serve.
American, Beans, Condiments, Gluten-Free, Good/High Fiber, Good/High Protein, Low Fat, Macrobiotic, No Sweetener Added, Pasta, Soup, Chili & Stews, Vegan, Wheat-Free


text:
LISBON - In 2009, a non-profit organization founded by state Rep. Craig Newbold and his wife received $499,000 in federal stimulus money to start a small-business revolving loan program.
The Laus Deo Foundation's administration of the loan program has come under scrutiny by Nick Barborak, Newbold's opponent in the Nov. 6 election, who said Newbold's for-profit businesses may have improperly benefited from one of the loans that was awarded for a business begun by a Newbold employee and his wife.
"It certainly calls into question whether this stimulus money, which was intended to create jobs for small businesses, was used properly. Or was this money simply redirected to places where it benefited people who are directly involved with the loan," said Barborak, who is a Democrat. Newbold is a Republican.
Barborak first raised the issue during Wednesday's debate hosted by the Morning Journal and produced documentation the next day to support his claims. The Morning Journal also received copies of the same documentation.
The $150,000 loan in question was awarded by the Laus Deo Foundation in 2010 to Carefree Enterprises LLC of Columbiana to start an online farmer's market featuring produce from local farmers, with the produce available for home delivery to the elderly and others. The president of Carefree is Linda Hiscox, the wife of Doug Hiscox, a former Newbold employee.
Barborak said Carefree used loan money to pay $18,391 to Soaring Eagle and Newbold Technologies for website work. Both are for-profit businesses operated by Newbold. He found this particularly troubling given Newbold's position as an elected official, although the stimulus money was awarded to Laus Deo in 2009, prior to Newbold running for office.
"I don't think people who are in public office should ever profit from the administration of tax dollars, and even the appearance of impropriety should be avoided. And in this case it calls into question why was the wife of an employee of Mr. Newbold's company receiving all of this money and then turning around and hiring his company to do the work," Barborak said.
Newbold said he treated Carefree the same as other applicants and decided to award the loan after reviewing its business plan and requiring sufficient collateral to cover the debt should the recipient become insolvent.
As for Carefree contracting with his software companies for website services, Newbold saw nothing improper with the arrangement because he did not personally benefit.
"I don't benefit from my business because I've never taken a salary," and the companies have yet to turn a profit despite pouring millions of his own dollars into them, Newbold said, adding he put up $75,000 to qualify for the stimulus grant.
"Nick's just trying to make issues and create issues. Our objective is strictly to help the economy in Columbiana County. That's been my mission since I came back to the county," he said.
Carefree has since gone out of business but continues to make its loan payments. "They basically ran out of money ... It didn't work out," Newbold said, adding Mr. Hiscox no longer works for him due to budget cuts and may have been gone by the time he approved the loan.
Barborak had other problems with the loan awarded Carefree and other aspects of how the program was administered.
"(Newbold) was aware that he couldn't use it for his own benefit," Barborak said of the loan money. "I don't know if he broke the law or violated regulations, but it should raise a question in people's mind whether it was appropriate."
Funding for the loan program came from the U.S. Department of Agriculture, and Newbold said USDA representatives have twice audited the program since loans were issued, "and they didn't have any problems. I think this validates we didn't do anything improper."
Because of these questions, Barborak believes Newbold Technologies should reimburse the Laus Deo Foundation the money it was paid and turn over the loan program's administration to another agency.
Gary Bonnell of East Liverpool contacted the Morning Journal on Thursday to say he was responsible for compiling the information about the Laus Deo loan program. Bonnell said he met this week with officials from the FBI and U.S. Department of Agriculture and was told the matter will be referred to the appropriate officials for further review.
Laus Deo has issued 16 loans, and 12 of the applicants are still in business, Newbold said. Two of the four that have ceased operations continue to make loan payments, and legal action has been taken against another recipient to recover the money.
Newbold noted the businesses created 70 jobs to date, "so that's what makes me feel good ... They (USDA) even told me we were one of the better-run programs as far as success and creating jobs."
Newbold is confident the loan program has been run fairly and in compliance with the law and suggested Barborak's time could have been better spent pursuing the large number of property tax delinquencies in his capacity as county treasurer.
"Maybe Nick should've been going after the $11 million in delinquent taxes. Shouldn't someone be asking him about that?" he said.
Barborak said the $11 million number is a moving target because the delinquent tax rate is always increasing and decreasing as people pay their bills. He said the average is more like $6 million, "which is still not acceptable, but you have to understand that a lot of that is tied up in bankruptcies and we can't do anything about that."
Barborak said a significant portion of the delinquencies are also subject to foreclosure actions that can take years to wend their way through the legal system before the county can collect.
"We've been very aggressive in collecting delinquent taxes, and this year I think we set a record of $5 million," he said, adding more than $1 million of that came from the sale of the Firestone Farms development. "That certainly helped."


text:
This morning when I was helping out in Grayson's classroom and I thought no one was looking I buried my nose in a Reader, hardback and big pages. It smelled just like second grade.
We've been here two months now. I almost can't believe that. It feels like a lifetime! In the best way, I mean, look at these photos. And it's April four, again, and I've come to the place now almost three years to the day, rushing in between school pick up and baseball practice to gather all four at the ocean wayside, wind and rain whipping around and risking all papers and drive-up coffee receipts blowing out as soon as the car doors open. And I was like, I can not force this. And it's totally okay. There are better photos still on the camera from last week and they don't give a care about the date.


text:
Kate Gregory, Ale Contenti and Steve Teixeira: VC++ 2008 and Beyond
- Posted: Nov 26, 2007 at 10:38AM
- 14 comments
Loading user information from Channel 9
Something went wrong getting user information from Channel 9
Loading user information from MSDN
Something went wrong getting user information from MSDN
Loading Visual Studio Achievements
Something went wrong getting the Visual Studio Achievements
Right click "Save as…"
Oops, something didn't work.
Charles wrote:Sinofsky isn't over there [Office division] anymore, so it should be safe.
Nothing, really. Just a smart (I need to watch my language) comment...CMinh wrote: Charles wrote: Sinofsky isn't over there [Office division] anymore, so it should be safe.Now, what did you mean by that?
I really don't like the "shiny objects" analogy. Try asking IBM how many of those conversions from mainframes to Microsoft software were "green fields." Now that Microsoft is the landscape, not IBM, suddenly those "green fields" are "brown fields?"
The disconnect here is why those libraries that are only available to C++ programmers are not available to .NET programmers. Maybe you should have made them available to .NET programmers? Not only are they not available, but there is no publicly available roadmap for when that might happen, if ever.
I loved the IntelliSense discussion!
Hello CPrest
Please look at Herb's more recent blog on GC and C++0x: http://herbsutter.spaces.live.com/blog/cns!2D4327CC297151BB!330.entry
Damien Watkins wrote:
Hello CPrest
Please look at Herb's more recent blog on GC and C++0x: http://herbsutter.spaces.live.com/blog/cns!2D4327CC297151BB!330.entry" href="http://herbsutter.spaces.live.com/blog/cns%212D4327CC297151BB%21330.entry"> http://herbsutter.spaces.live.com/blog/cns!2D4327CC297151BB!330.entry
[Troll nonsense removed]
alecont wrote:Hi CPrest,
You don't always need a garbage collector to get a simple memory resource management
For example, if you extensively use smart pointers like tr1::shared_ptr, you can safely manage memory with familiar C++ concepts (like for example determistic destruction).
With tr1::shared_ptr, you call new() once and you don't need to worry about calling delete to release the memory. The smart pointer will take care of releasing the memory when the reference count goes to 0.
tr1::shared_ptr is part of the TR1 addition to the Standard C++ Libraries. TR1 will be released on top of VC++ 2008 very soon. Check out vcblog for more info on this!
HTH, ale.
ZippyV wrote:Charles, did you forget to white balance your camera? Everyone is wearing a pink shirt.
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


text:
MARTINSBURG - As the time dwindles before the Berkeley County Council decides county organizations' budgets, one Falling Waters resident asks that council members remember the needs of the community when approving budget requests.
At Thursday's Berkeley County Council meeting, Cheryl Rogers appealed to council members on her longtime concern of the lack of recycling facilities in northern Berkeley County.
"People I've talked with tell me they are just throwing things in the garbage, and that just breaks my heart to think that it's going in a landfill," Rogers said.
Due to financial constraints, in 2009, the Berkeley County Solid Waste Authority closed its Marlowe Recycling Center and a mobile recycling truck that traveled to Falling Waters every Thursday.
Since then, Rogers said she has been working with Clint Hogbin, chairman of the BCSWA, to find a solution to restore recycling services.
"Our board is completely sympathetic for their needs to provide recycling services. It's actually a component of our long-term goals," Hogbin said. "In 2009 that was a direct result of the economy at the time. The (Berkeley County Commission) cut our funds from the high $90,000s to $68,000."
Monday, Hogbin will be before the county council, as the Board of Review and Equalization, presenting the Solid Waste Authority's budget request for fiscal year 2013-14.
Included in the total requested amount is $500 earmarked for the purpose of identifying land in North Berkeley for a recycling center. Hogbin is also proposing to set aside $500 for land identification purposes for Hedgesville.
"I have been told there's no money, and we're not getting anything unless (the BCSWA) gets five acres for a permanent location," Rogers said.
Not expecting an immediate solution, Rogers said she just wanted the issue to be on the county's agenda and for members to work with northern Berkeley County residents in achieving a permanent recycling facility.
"I can tell you that Clint's asked for additional money this year; whether we can afford to fund it may be another issue," said Doug Copenhaver, Berkeley County Council vice president.
Hogbin will be petitioning the Berkeley County Council for $97,300 - approximately $20,000 more than was approved for the 2012-13 fiscal year allotment.
- Staff writer Samantha Cronk can be reached at 304-263-8931, ext. 132, or email@example.com.


text:
An electroencephalogram (EEG) is the most important diagnostic tool in the evaluation of patients with seizures. An EEG measures the electrical activity of the brain and is shown as brainwaves (squiggly lines) that can be printed on paper or stored in a computer for later review by a physician.
A normal electroencephalogram (EEG) is shown to the right. EEG recording is a safe and pain free testing process. EEG equipment has come a long way over the past 20 years from large cumbersome polygraph equipment to smaller more advanced digital technology. The biggest impact in the field of EEG technology over the past 30 year was the application of the computer to the process. The digital EEG device is a computer connected to an amplifier that amplifies the brain signal so that it can be easily seen. The EEG signal is small, in the microvolt range; it has to undergo drastic amplification to be seen. The heart by contrast puts out millivolts (milli is a thousandth of a volt), while the brain puts out microvolts (micro is a millionth of a volt). The amplifier is connected to the electrodes (small metal discs) that are attached to a patient's head with a gel or cream that makes the electrical connection. The electrodes connect from the head to the recording system, which are attached to the scalp according to a standardized system of electrode placement called the Ten Twenty placement.
The ten-twenty placement system (right) is a standardized method for measuring the head for electrode placement. A technologist measures a patient's head according to this standardized system and attaches small discs to the head. The electrodes may also be attached to the scalp by means of collodion (the base for fingernail polish). Collodion is often used for electrode placement for long-term epilepsy monitoring. It adheres well to the scalp and electrodes do not come off easily with movement or sweat.
There are a few disadvantages of collodion, such as the smell of ether or fingernail polish, as well as the time it takes to place the electrodes (45 minutes to an hour). Patients have to remain very still during electrode placement.
A routine screening test of about 30 to 45 minutes is performed when seizures are suspected. It is important for the patient to fall into a light sleep during the procedure once an awake portion has been recorded. Sleep often brings out abnormalities that may not be seen in the awake state. Only 50 percent of abnormalities may be seen in the awake state and may increase to 85 percent in the asleep state, particularly for patients with epilepsy or seizures. Patients are frequently asked to open and close their eyes. A flashing light is used to see whether the patient is photosensitive, that is, if he or she has an unusual sensitivity to light. Some patients suffer from photosensitive epilepsy and may experience small seizures as a response to the flashing light. This procedure is called photic stimulation and is considered to be an activation procedure meant to bring out abnormalities seen with seizure activity.
Sleep is also considered an important activating procedure that may show seizure acitivity. Sleep deprivation is often used to ensure that patients fall asleep during the procedure. Sleep deprivation may be defined as a few hours less than the usual amount of sleep a patient usually obtains each night. Sleep deprivation for this purpose is also often used to activate seizures or abnormal activity otherwise not seen.
Another routine activating procedure is called hyperventilation, where the patient is asked to breathe in and out rapidly for three to five minutes. This often brings out seizures known as staring spells or absence. Staring spells are a common type of seizure that have a typical brainwave pattern called the "3 per second spike and wave discharge" (Right). This pattern is usually seen in patients with absence or what used to be referred as petit-mal seizures. These seizures may be seen as a result of hyperventilation. This is most often seen in young children under the age of ten years.
If routine recordings do not produce evidence of seizures, 24-hour continuous long-term video and EEG monitoring may be recommended. This type of monitoring may be done in the hospital, or as an outpatient. Monitoring that is performed as an outpatient is called ambulatory monitoring. During both procedures, inpatient or outpatient, combined or synchronized digital video recording is obtained. These studies help the epileptologist diagnose the epilepsy and identify where the seizures are coming from as well as to classify the epilepsy type. Identifying the seizure type or classifying the epilepsy is important for proper treatment and management. There are many anti-epileptic drugs (AEDs) that are given for specific epilepsy types. This also helps to distinguish between true epileptic seizures caused by the brain and non-epileptic seizures caused by other physiologic or psychological factors.
In certain situations people who have never experienced seizures may show epileptic abnormalities on their EEGs. This means that a genetically they may have a propensity for a certain type of epilepsy. Generally speaking this type of epilepsy is easy to treat with anti-epileptic drugs (AEDs) and in many cases patients outgrow this type of seizure disorder.
Physicians who interpret the EEG results rely on the EEG as the most reliable indicator of a seizure disorder along with other complimentary information such as the medical history and other tests.
For additional information, a second opinion, to make an appointment or refer a patient, please call 310-423-6472 or email us at firstname.lastname@example.com.


text:
Top Definition
An expression used to show grief, sorrow, sadness, depression, or anger.
af tylaxdude 23. marts 2009
Trending Now
Can you define these popular missing words?
an expression of sorrow, disbelief, anger, or confusion.
Thats so mehe right now.
af tylaxdude 23. marts 2009
The word mehe can be used in almost every situation. It can show happiness, sadness, terror, or pain. It can be used in substitution of words to gives sentences extra impact. The word can be used as a noun, verb or exclamation. Really mehe is a word for everything. Mehe is not to be confused with maha, which is only an exclamation of anger.
I won, and i was so mehe.
When he ran at me i was like, MEHE!!!
Hey you, mehe, im talking to you.
When he ran at me i was like, MEHE!!!
Hey you, mehe, im talking to you.
af Ghostfacedkilla 9. juni 2009
A slang term for the male genitalia, once popular among grade school students in the mid-90's.
Timmy was in the bathroom playing with his mehe.
af Tim Heidecker 12. oktober 2007
When something extremly funny (or not)happens you should repeatedly yell this word.
Someone trips over. You yell "ME-HE" in a high pitched voice at them. MEHE!
af Gems 27. juli 2003
A slang term for a male prostitute. Often used in the gaming world.
He missed the shot, he's such a mehe.
af barhomie 13. november 2007


text:
Watch: Man records video of Texas explosion
Man getting video of fertilizer plant fire when it explodes
UPDATED 8:23 AM CDT Apr 18, 2013
The massive explosion at a fertilizer plant in West, Texas, late Wednesday was caught on tape.
A man who was in his car with his daughter was shooting video of the fire burning at the plant when it suddenly exploded.
(Mobile/Tablet users, click here to watch the video)
He and his daughter were not hurt by the impact of the blast, but she's heard on the tape saying that she can't hear -- and begging her father to leave the area.
The explosion destroyed homes and businesses in the town near Waco, Texas. There was no immediate word what caused the explosion.
Copyright 2013 by KMBC.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Acadia Streets
HomeZilla is building a collection of all homes in Alberta. The goals behind collecting this data are many. Two of the most important are allowing people to be able to easily find addresses,to help people do research when buying a home, and also to track when homes go on sale
HomeZilla has addresses for 1 streets in Acadia, Alberta.
The list of civic address in Nova Scotia is for sale. If intersted email us at info [at] homezilla [dot] com
List of streets in Acadia, Alberta
Browse Houses by Province or Territory
Alberta Cities with Real Estate Listings (Recent Alberta Listings)


text:
Top Definition
A awesome pokemon clan, where people in IRC DOMINATE other clans such as UA, and MD. Originally DracoAlliance, this clan has obtained other members and is now as strong as ever. See dracohero for more details.
OMG IT'S A NoMercy MEMBER RUN FOR YOUR LIVES!
di NMember 31 dicembre 2010
Trending Now
Can you define these popular missing words?


text:
The AAP discourages TV and other media use by children younger than 2 years and encourages interactive play. For older children, total entertainment screen time should be limited to less than 1 to 2 hours per day. You'll all discover more constructive ways to fill the time, separately and together. Some examples include:
Expect to encounter resistance at first. After all, change is never easy. If yours is a household where the TV regularly blares for five, six or seven hours a day, wean the family gradually. Try cutting down by an hour a week or go cold turkey. The two-hour maximum includes time spent in front of any screen, including the computer and video games.
Make TV viewing an active choice, as if you were picking a movie from the newspaper. "How about if we watch at seven-thirty?"
Hide the remote! Eliminate channel surfing, which encourages passive viewing. When family members have to get up to change the channel, they may be more selective about the programs they watch. If nothing else, at least they'll be getting some exercise.
When the show you wanted to watch is over, turn off the set. Also, if the program you choose isn't compelling enough to watch actively, it's not worth keeping on as background noise.
Make a household rule: no TV in your youngster's bedroom. Although adolescents deserve their privacy, they hardly need another reason to isolate themselves from the rest of the family. Children should watch their favorite shows in a central area of the home. Even if you're not sitting down with them, this allows for conversation when you're passing through and enables you to keep closer tabs on what they're watching.
Whenever possible, videotape programs and watch them later. Fastforwarding through commercials will shave ten minutes off every hour of TV viewing, not to mention help your youngster hold on to her allowance longer. (When watching TV in "real time," mute the sound during the breaks.) Taping shows ahead of time also allows you to hit the PAUSE button when you want to make a point or have a family discussion about something you've just seen onscreen.
Discourage repeated viewings of the same video. The graphic language, violence and sexual content of movies rated PG-13 and R can have a cumulative effect on a child if they're watched over and over again.
Harness the power of television in a positive way. For all its flaws, TV can be a valuable tool for learning and expanding one's awareness of the world.
Here's what you can do to help your child get the most enjoyment out of the experience:
Make use of ratings systems to know whether or not a program or movie is appropriate for your child. The National Association of Broadcasters (NAB), the National Cable Television Association (NCTA) and the Motion Picture Association of America (MPAA) jointly developed the "TV Parental Guidelines," similar to the movie-rating system adopted by the MPAA in 1966.
Talk back to your TV! Parents are rightfully perturbed about the seemingly endless stream of violence and sex in television programs and films, including those aimed at young people. We should be equally concerned about what they don't show: namely, the real-life consequences of such actions. For example, 75 percent of the violent scenes on TV fail to show the perpetrator expressing remorse, or being criticized or penalized for his actions. Similarly, a study from the Henry J. Kaiser Family Foundation found that over a one-week period, roughly 90 percent of the television programs containing sex scenes did not include a single reference to the risk of pregnancy or acquiring a sexually transmitted disease from unprotected sex.


text:
How to Make Easy Egg Salad (02:07)
Egg salad sandwiches wrapped in wax paper feel like they belong in a Normal Rockwell painting. In this episode of The Easiest Way, Lisa Lavery of the CHOW Test Kitchen harks back to her childhood and shows you how to use our simple Egg Salad recipe to create this classic at home.
Search Videos


text:
Top Definition
When you use Smuckers grape jelly as a lubricant for jerking off. Or any other flavor would work too, I suppose. From some random episode of Reno 911.
Wait, I thought that's what the jelly in the glove compartment was for. If it's not for jelly tugs, why is it in there?
作者 skeptical jesus 2008年7月16日
Trending Now
Can you define these popular missing words?
The act of inserting ones member into a jelly jar with the intention of using it to jerk off.
Junior should've taken his underwear out of the squad car when he was done with his jelly tugs.
作者 Dave56678 2008年7月13日
A jelly tug is masturbating with any type of jelly or jam
I ran out of KY so I decided to use grape jelly for a nice jelly tug.
作者 Sqitso 2008年7月15日
The act of male masturbation using grape (or any other flavor) jelly as a lubricant
Jim was so horny that he just lubed up with concord grape and went with a jelly tug.
作者 dean-osteen 2008年7月12日
Jerking off using jelly (usually grape jelly) as opposed to normal lubricant.
"Don't jelly tug outside, or the mosquitoes will get you."
作者 JellyTug 2008年7月10日
When a man masterbates using jelly as a lubricant.
Best results if jelly is microwaved so jelly is fairly warm. Increases pleasure.
Best results if jelly is microwaved so jelly is fairly warm. Increases pleasure.
I was looking to spice up my masterbatory experience so I gave myself a jelly tug. Wasn't that messy either.
作者 T.S. Cooper 2008年7月10日
I caught my brother doing a jelly tug last night.
作者 Foster414 2008年7月12日


text:
DRSol is Dominican News, Weather, Videos, Forums & Travel Information
Untitled Document
• Welcome to the new DRSol
• Latest News
• Random Latest News
• Archives
• Dominican Republic One
• Dominican Today
• Sosua News
• El Nuevo Norte
• Listin Diario
• Island Weather
• Tropical Update
• Surf & Kite Forecasts
• Climate Information
• Earthquakes!
• XR's Weather Blog
• Live Webcams
• Tourist Videos
• Photo Gallery
• Music Library
• Live Radio & TV
• Returning Soon
• Partially Open
• Returning Soon
• Returning Soon
Feedjit Live Blog Stats
DRSol :: News Archive :: Election results will be known on 20 May
The Dominican Sun
"Daily Dominican Republic News in English Since 2004"
Wednesday, April 25th, 2012
Election results will be known on 20 May
Story Text & Photos © 2012 by DR1
Apr 25 2012 02:29AM
- Despite the recent controversy affecting the results reporting process, once again the head of the Central Election Board (JCE), Roberto Rosario, has issued statements that confirm his goal of having the election results known across the country by the end of Election Day, 20 May. El Nuevo Diario quotes Rosario as saying that the first bulletin will be issued at 10pm and that the winning candidate will be known before midnight. The JCE president reiterated that every precaution is being taken to avoid any sort of difficulty in the transmission of the voting results. He told eminent journalist Nuria Piera that a winner would be declared, even if by just one vote. The JCE had issued a resolution calling for simultaneous availability of results to the JCE, political parties, the media and on the Internet. But the latest statements by Rosario reveal he is having second thoughts on the vulnerability of the transmission of the data and there is concern he may revoke the disposition. Read original at
(Posted 02:29 Wednesday by DRSol NewsHound. Viewed 400 times.)
Send to Friend
View Full
Display an exclusive
DRSol Translated
version of these news items
Send to a Friend
Your Name:
Your E-Mail:
Your Friend's Name:
Your Friend's E-Mail:


text:
'Gerald' | Regular Fit, Traveler Spread Collar Italian Cotton Dress Shirt by BOSS
Style No. 50273075
Free Shipping
This regular fit dress shirt from our BOSS Traveler Collection is crafted in 100% Italian cotton and features a natural stretch giving a comfortable freedom of movement. A spread collar, mitered cuffs, and a gently rounded hem shape this style.
- Regular fit
- Traveler Collection
- Spread collar
- Two-button mitered cuffs
- Rounded hem
- Reinforced buttons
- Back yoke with no pleats
- Packaged shirt includes a Hugo Boss Sewing Kit with spare buttons and collar bones
- Back length: 79 cm (31.1 in.) in size 15.5
- 100% Italian cotton with natural stretch


text:
The view from the Blausee to the nearby Valais four-thousand-metre peaks (Weisshorn, Matterhorn and Dom) is breathtaking! Lake Blausee lies at an altitude of 2207m and its water can heat up to 20 degrees. Visitors find Barbecue facilities close by and can enjoy free access to the lake shore. Access from Riederalp by the Riederalp-Moosfluh cableway, then by foot to the Blausee. (15 min.).
Access: by train or car to Mörel and then by cableway to Riederalp.


text:
Wanna take photos of the Earth from the deep in the atmosphere… well, apparently with $150 you can! This story of Oliver & Lee from MIT who accomplished this feat, taking 4000 photos of the Earth from the Stratosphere definitely got me buzzing in my chair.
The story is used as an example of disruptive ideas, those kinds of innovation that just literally pull the rug right from under the feet of the current status quo in that industry. John Sviolka in this article on the Harvard Business site talks about disruptive innovation and goes on to identify some interesting ways that certain businesses or innovations have become disruptive from Craigslist to Southwest Airlines. Here's a quick point summary:
- Simultaneously simplify a number of advantages together to create a new cost base
- Give away the other guy's razor!
- Look for new, radically cheaper ways to do the job
- Think about leveraging a very few individuals with extraordinary talent
Filed under: Uncategorized, disruption, disruptive, entrepreneurship, innovation


text:
Wall Street Decline Takes Its Toll...
Quadruple Helices Appear To Have Role...
Adapting to Evolving Business Environments Is...
Expanding Use of NGS Has Largely...
Cytogenetic analysis of chromosomes provides the foundation for the clinical diagnosis of genetic disorders caused by chromosomal abnormalities. Initially, chromosome banding techniques such as G-banding were used as diagnostic tools. Banding techniques, however, lack the specificity and resolution needed for the diagnosis of a wide variety of chromosomal abnormalities.
Molecular cytogenetics (fluorescent in situ hybridization or FISH) combines classical cytogenetics with molecular techniques, which significantly increases the resolution and specificity of cytogenetic analysis. FISH with chromosome-specific probes reveal hybridization signals, even on inadequately spread metaphase chromosomes and interphase nuclei. It is capable of detecting subtle chromosomal abnormalities that are not detected using conventional cytogenetic analysis. Additionally, FISH allows quantitative analysis of target sequences, thus providing an advanced tool for genetic research.
During FISH, a fluorescent-labeled nucleic acid probe with sequences complementary to the area of interest on a chromosome is hybridized to chromosome spreads or nuclei. Probes bound to the target sequences are visualized by fluorescence microscopy.
During multicolor FISH, the use of fluorescent dyes with different emission wavelengths allows for the use of multiple probes during a single hybridization to simultaneously target different chromosomes or different areas within a chromosome. FISH can be qualitative (to study the presence, absence, or position of a sequence) or quantitative (e.g., to study the length of a repeat sequence).
In studies requiring quantitative measurement of a target sequence such as telomere-length measurement, it is critical to have slide-to-slide and day-to-day reproducibility to enable data comparability across various hybridizations. It is also crucial to have uniform hybridization to minimize the signal variations within a slide.
Current methodologies often utilize various sealants around a cover slip to create a sealed chamber, and hybridizations are incubated in a conventional oven. These methods generate data with high day-to-day variability in fluorescence intensity and are susceptible to photo-bleaching of fluorescent dyes.
In this article, we describe a new method for performing quantitative telomere FISH using the Hybex® microarray incubation system from SciGene (www.scigene.com). The Hybex hybridization chambers have advanced sealing to prevent loss of humidity and photo-bleaching, resulting in a more uniform hybridization and brighter signal, which are critical for quantitative FISH that requires high sensitivity and reproducibility. We have applied this procedure for molecular epidemiological studies and obtained highly reproducible results.
Metaphase chromosome spreads were prepared following standard cytogenetic procedures. Lymphocyte cultures were established by inoculating 1 mL of fresh blood into 9 mL of blood culture medium (RPMI-1640 medium supplemented with 15% bovine serum and 1.5% phytohemagglutinin). The cultures were incubated at 37ºC for four days. To arrest the cells at metaphase, 0.2 µg/mL colcemid was added to the culture one hour before harvest. The cells were treated in hypotonic solution (0.06 M KCl) at RT for 25 minutes.
The chromosome preparation from cultured lymphocytes were dropped onto a clean glass slide, fixed in 3:1 methanol:acetic acid for one hour at room temperature, and then air-dried. Slides were then dehydrated in an ethanol series (2 minutes each in 70%, 80%, 90%, and 100% ethanol) and then air-dried for 15 minutes.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
The state's Commission on Higher Education on Thursday gave Charleston School of Law leaders a green light to discuss a possible sale of the private law school to the public College of Charleston.
Edward Westbrook, one of the law school's founders and a member of its board, had asked the commission to waive for 90 days a prohibition in the school's operating license agreement that prevented law school leaders from discussing such matters with the college.
Commissioners said that while they voted unanimously in favor of permanently waiving the condition, they are not taking a stance on the sale. They simply wanted to remove an impediment to conversation on the controversial matter.
Retired U.S. magistrate judges George Kosko and Robert Carr, two of the three remaining founders and board members of the law school, however, announced Tuesday that they were proceeding with a sale to the for-profit InfiLaw System. Kosko and Carr represent the majority of the three-member board, and continue to say that a sale to InfiLaw is the best move for the future of the school,
Kosko and Carr said in August that they were willing to consider well thought out and financially responsible alternatives for the school's future, but they didn't receive any proposals by their Oct. 1 deadline. Some people and groups have proposed vague alternative proposals, they have said, but no one has come forward saying, 'We want to buy the law school, and here are our plans to run it.' "
In a statement Thursday, Kosko and Carr said, "We are now obligated by contract to move forward with InfiLaw. Indeed, InfiLaw has filed its application for licensure with the Commission on Higher Education and we understand that process is moving forward."
Many students, alumni and members of the local community have expressed outrage since law school founders announced in July they had entered into a management services agreement with InfiLaw. Outrage grew when they announced in August that they planned to sell the school to InfiLaw. Some of them think a sale to InfiLaw could diminish the value of a Charleston School of Law degree. The company owns three other law schools, which many consider to be "diploma mills."
Westbrook, who attended the commission meeting, said he was pleased with the decision, which gives everyone concerned about the law school more time to explore options for its future, including transferring ownership to the College of Charleston. That option, Westbrook said, "is likely to be a lot less controversial than InfiLaw."
Westbrook stated in a proposal last week that at least three other alternatives to InfiLaw exist:
Paying Kosko and Carr a portion of the value of their shares, and remaining a limited liability corporation while the school stabilizes. Kosko and Carr could stay on as board members, but the school also would have respected members of the legal community join the board. Kosko and Carr could redeem the rest of their interests after things have calmed down.
Redeeming all of Kosko's and Carr's interests, just as was done for Alex Sanders and Ralph McCullough, the final two of the original five founders.
Exploring transferring ownership of the school to the College of Charleston. Westbrook said that if that option were selected, he would be willing to donate his entire one-third ownership interest to the college.
Richard Sutton, the commission's executive director, said InfiLaw has applied for a license, which it would need if it ultimately becomes the new owner of the Charleston School of Law.
The commission must approve licenses for all for-profit higher education institutions in the state, he said, and a new owner must apply for a new license.
The commission will work along two parallel paths concerning the law school, he said. It will being the often lengthy process of considering InfiLaw's license application while communicating with law school leaders who are considering other options.
College of Charleston spokesman Mike Robertson said the college is interested in entering into discussions about a possible acquisition of the law school. "College leadership has heard from many South Carolinians about their concerns for the future of the Charleston School of Law. Given these repeated expressions of concern about the future of the law school and its role in Charleston and the state, coupled with today's action by the Commission on Higher Education, the college is prepared to enter into these discussions if the Charleston School of Law indicates its interest."
Reach Diane Knich at 937-5491 or on Twitter @dianeknich.


text:
Although women are breaking the glass ceiling when it comes to running companies and our country, the average woman's salary won't equal the average salary of a man until the year 2058.
That's according to the Institute for Women's Policy Research.
Since the institute started collecting this data, the gap has actually gotten wider, as women's salary growth has stalled.
Women still earn about 77 cents to every dollar men make, and this number has stayed about the same since 2007.
The institute believes slow growth for the bottom economic earners, which affect women more than men, and the lack of sufficient family medical leave have pushed women out of the workforce over the last few years.