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Developers of DTC Genetic Testing Are...
Wall Street Decline Takes Its Toll...
As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Services from distinct companies sometimes provide different pieces of advice, and this may be a source of confusion for both consumers and professionals.
"In 2009, I designed a mobile application platform to provide a side-by-side comparison of different genes and SNPs that different consumer genomics providers review," says Melanie Swan, founder of DIYGenomics, a nonprofit research organization that proposes to use genomic information to complement the information consumers obtain from healthcare professionals.
A free and open-source application offered by DIYGenomics, currently informative on up to 20 health conditions, the response to 200 different drugs, and athletic performance information, is available on three platforms: Android, iOS, and Windows Phone. "We've had about 10,000 downloads," says Swan.
Genomic information uploaded on the mobile application can actively guide healthcare decisions. For example, a patient with heightened risk for a specific cancer may decide to undergo more frequent screenings, or use information about athletic performance to customize training programs. "In my case, I have more mutations in my strength-related genes, and this prompted me to include more weight-lifting into my daily regimen," reveals Swan.
These developments are paving the way for the time when personal genome information will be included in everybody's medical file. "We are coming into an era where health becomes an information science, and by integrating multiple different types of data files about an individual, we can use quantitative data at the level of risk and probability to develop a preventive medicine strategy and work toward keeping people healthy," explains Swan.
"We wanted to develop a portable device to perform DNA- and RNA-based assays," says Syed A. Hashsham, Ph.D., professor of civil and environmental engineering and Michigan State University. Recently, Dr. Hashsham and colleagues described Gene-Z, a user-friendly device that relies on a disposable microfluidic chip, and allows the simultaneous quantitative detection of multiple genetic markers with high sensitivity and specificity.
In this application, real-time measurement of isothermal amplification products using fluorescence allows the quantification of multiple genetic markers at a single temperature, and the wireless interface and smartphone application for data analysis and reporting illustrate its utility for affordable and reliable point-of-care genetic testing. Point-of-care tests are ideal for assays that have immediate or long-term health benefits or may save lives, and for those that present a minimal risk for false-positive results and have full support systems in place for consumers undergoing testing.
"So there may be some assays that are never good for a cell phone, while other are very good," says Dr. Hashsham. This strategy is not limited to genetic assays, but any device developed for genetic assays may also be adapted for antibody-based or chemical assays, because most reactions rely on colors that develop based on a specific signature molecule.
"What I have next in mind is using color assays for diseases such as diabetes or measuring cholesterol levels," says Dr. Hashsham. One of the challenges with point-of-care testing is not the technical challenge but the business model, because an emerging or a new technology generally boasts about its low cost but at least in the initial stages must get off the ground without high sales volumes.
"But if we are able to develop genetic diagnostic applications on cell phones, we can reach billions of people without the need for expensive monitors. As we all know, the number of people with a cell phone is already more than those with a toothbrush," says Dr. Hashsham.
According to recent Centers of Disease Control and Prevention estimates, 80% of heart disease and strokes and 40% of cancers are preventable through the elimination of risk factors. A key requirement to facilitate the development of management strategies is the identification of actionable risk factors. Mobile health applications, which involve technologies that monitor parameters such as heart rate, body weight, and blood pressure, help integrate these components, which normally would not be brought together, and allow healthcare teams to gather real-time data while the patient is not even in the office.
"All these data allow real-time continuous monitoring and, most importantly, real-time feedback," says Samir Damani, M.D., PharmD, founder and CEO of MD Revolution. By allowing people to track their activities and increase their awareness of what they are doing, these initiatives help motivate changes in behaviors, such as healthier eating habits or increased exercising. "Mobile health is an enabler to measure, monitor, and motivate," says Dr. Damani.
MD Revolution has its own software system that helps integrate these mobile components, and shares them not only with the medical team but also with the patient. "One of this model's strengths, in comparison with traditional healthcare settings, is patient empowerment through mobile technology and genetic information, and this will shift the paradigm from a doctor-centric to a patient-centric model of healthcare, in this country and beyond," explains Dr. Damani.
Applications that bring genetics and genomics closer to consumers promise to start filling a longstanding gap in public awareness and preventive medicine. These platforms help identify medically actionable information and deliver strategies for prophylaxis, therapy, and surveillance, and their development is foreshadowing a time when consumers and healthcare teams can routinely incorporate personalized genomics into lifestyle decisions.
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In trying to put together an Eastern all-sports conference 30-plus years ago with the likes of Pitt, West Virginia, Syracuse, Boston College, Temple and Rutgers, Joe Paterno often said he thought Maryland could eventually be enticed to join.
It's taken three decades, but with the Big Ten's confirmation Monday that Maryland will join the league, effective July 1, 2014, Penn State and the Terps are finally becoming conference brothers.
The Nittany Lions are about to complete their 20th year in the Big Ten, and while there's no question some of their followers - myself included - are still getting used to it (and its officiating) and miss playing Pitt on Thanksgiving weekend, there is little doubt the conference has provided top-of-the-line competition and enormous financial stability.
Clearly, this is a business decision.
Nobody - even at Penn State - has been longing for a resumption of the Penn State-Maryland football series. And certainly no one is going to stop traffic for Maryland vs. Purdue. Ditto Rutgers, which is strongly rumored to be the next Big Ten addition and will balance the league at 14 teams.
Even though Maryland must swallow hard and say goodbye to its basketball rivalries with Tobacco Road, the move makes sense as it's become painfully obvious that football pays the bills and allows these athletic departments - and particularly the non-revenue sports - to function.
The last two additions, Penn State and Nebraska, are not in mega-media centers but boast rich football histories.
Maryland and Rutgers are not enticing football programs, but they definitely bring major markets that will help widen the Big Ten brand, largely through the outstanding Big Ten Network, into the Washington-Baltimore and New York areas.
The expansion will help Penn State more than it hurts.
The downside is the Nittany Lions will no longer be the only one selling Big Ten football in the East, although PSU never considered Maryland or Rutgers a rival as much as both were regional opponents. This expansion will allow players from the New York or Virginia areas - traditionally fertile territory for Penn State - to stay closer to home and play against Ohio State, Michigan and, starting in 2014, PSU.
On the other hand, especially during these turbulent times when the Lions will be closer to a 7-5 team than a title contender (when they become eligible for one in 2016), it will be far more desirable to make a driveable trip to Maryland or Rutgers than it will be to trek to Purdue, Indiana, Illinois or Minnesota - teams similar to Maryland and Rutgers.
This year's visit to Virginia, an easy four-hour ride, reinforced that as thousands of PSU fans showed up at Scott Stadium.
Then there's the history. There wasn't much with Rutgers; the Knights beat PSU twice in 24 meetings - once in 1918 and then in 1988 with Dick Anderson at the helm.
Though it only beat the Lions once, Maryland typically played Penn State tougher. From 1960-93, the teams met almost annually and, during one stretch, it was a one-touchdown game for seven straight games (1982-89).
Overall, Maryland and Penn State met 37 times. The Lions' most familiar Big Ten opponents are Ohio State and Michigan State. Both have played the Nittany Lions 28 times.
Finally, for Penn State, the Big Ten has gotten a little more local.
Rudel can be reached at 946-7527 or firstname.lastname@example.com.

subset: commoncrawl


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Full CoverageWEATHER
Marine life spotted on some streets in MassachusettsUPDATED 8:23 AM CDT Oct 30, 2012
Meteorologist Mish Michaels spotted fish and jellyfish along one flooded street along the Southeast coast of Massachusetts.
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National Alliance on Mental Illness
page printed from http://www2.nami.org/
(800) 950-NAMI; email@example.com
Visualizing the Road to Recovery
Healing Vision: Commissioned Photographs for Appalachian Behavioral Halthcare
By The Athens Photographic Project
By Kathleen Vogtle, NAMI Communications Coordinator
The path towards healing and recovery is unique for each person living with mental illness. Listen to their stories and you will discover that many have found a physical or creative outlet. Activities, such as walking, writing or music are not only enjoyable but also can help a person center themself.
Appalachian Behavioral Healthcare (ABH), a psychiatric hospital in Athens, Ohio, saw photography as a powerful tool in the process of recovery, and commissioned the Athens Photographic Project (APP) to create a collection of images as a resource for their residents. APP began as a program under NAMI Athens, Ohio in 2000, and is currently an independent non-profit organization serving as part of Network of Care for The Alcohol, Drug Addiction and Mental Health Services Board of Athens, Hocking and Vinton Counties (317 Board) in Ohio. The APP has "supported mental health recovery in southeast Ohio by providing opportunities for community members living with mental illness to express themselves creatively through photography."
As part of their commission, the 38 artists participating in APP's 2012-2013, 30-week photography class sought "to provide patients with a large-format photographic print of their choice to display in their bedroom during their stay at (ABH)." The resulting images are now available in a new collection, Healing Vision.
As part of the introduction, Nate Thomson, Executive Director of AAP, describes the project:
"Artists had the unique opportunity to learn about the arts in the healthcare field and to then define for themselves how the arts heal. APP artists considered the symbolic quality of their subjects, use of color and light, as well as personal meaning.
"The result is a diverse body of work representing a full spectrum of emotion and complexity."
Thomson's description is wholly accurate. The sheer diversity of the subjects and themes portrayed by these images is inspiring. Photographs range from the realistic to the abstract. Many include people; an equal number do not. Landscape shots are displayed alongside detailed close-ups.
The students' descriptions of their photographs are equally as intriguing. Each is an intimate glimpse into the mind of the individual and their motivation for capturing the image. In many ways, these observations engage the viewer at an even deeper level, allowing them to feel as if they are capturing the image themselves.
Healing Vision provides a rare visualization of the road to recovery. The collection is a refreshing and empowering resource on an often long and difficult journey and serves as a reminder that we are not on this journey alone.


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LEWISTOWN - Inspired by the heart and driven by a need to help others, Ken Stuck, Ruth Ann Kephart and Lori Pfiester have started In Home Services of Central PA, a business dedicated to making life easier through daily living assistance.
The company consists of a CEO, Stuck, two directors, Kephart and Pfiester, and a host of locally hired team members that provide in-home services to local clients.
"We are a company of dedicated, conscientious, caring team members and service providers whose goal is to make life easier by providing outstanding in-home services with a sincere commitment to customer service," Stuck said.
In Home Services of Central PA caters mostly to the senior citizen population, which makes up 35 percent of Mifflin and Juniata counties, according to the 2010 U.S. Census. The goal of the company is to create a home environment where independence is possible and a higher quality of living is achieved, Stuck said.
Rather than providing medical assistance, the focus is on assisting with daily activities such as housekeeping, cleaning, food prep, morning care, evening care, personal shopping, gardening and much more, Kephart, director of client services, said.
"We are not a medical provider and we don't plan to be," Kephart said. "We are providing services to make life easier."
The services, Stuck said, are specifically designed to benefit a senior client as well as a younger client concerned about their aging parents' well-being.
"You have the children that are out of the area, but worry about their loved ones and you have the people that want to take care of their loved ones, but have to work during the day," Stuck said. "We can step in and help reassure them that their loved ones are getting quality service in their own home, where they want to be."
The process begins with a phone call to Lori Pfiester, director of operational services, to discuss the assistance and services you or a loved one might need, Stuck said. She then develops an individualized assistance plan which is turned over to Kephart who then picks a team member that fits into the plan.
It's important to make sure the chosen team member is the right fit for the client and that all services are being provided at above expectations, Kephart said. The next phase is a bit of a transition, she added.
"I go with the team member to the home for the first visit to make sure it's a good match and that everyone is at ease," Kephart said. "Visiting the home also allows me to check if more services are needed."
For example, Kephart said, an out-of-town child might know that mom broke her hip, went through rehab and is ready to go back home, but maybe they didn't know that she isn't doing the dishes or the laundry. We can help with that, she said.
"So making life easier has many connotations," Kephart said. "We want to help the client and the loved one, but we also want them to enjoy their time together rather than center it around the various chores that need to get done."
In addition to serving local senior citizens, In Home Services of Central PA is also available to assist the busy professional or family on the go, Stuck said. It's all about making life easier and providing more time for clients to spend with those they love, he added.
Though In Home Services of Central PA has not opened its Lewistown office, all services are currently available by calling (888) 881-2046 or through email at email@example.com. Services are provided at $18 an hour, with a three hour minimum, during the week and for $19 on the weekend.
For more information about In Home Services of Central PA, visit www.inhomeservicesofcentralpa.com.


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Noopur Raje, MD
Massachusetts General Hospital
Boston, Massachusetts, USA
Abstract Number:
J Clin Oncol 31, 2013 (suppl; abstr 8589)
Noopur S. Raje, Wolfgang Willenbacher, Vania Hungria, Andrew Spencer, Yulia Alexeeva, Thierry Facon, A. Keith Stewart, David Roodman, Evangelos Terpos, Amy Feng, Ada Braun, Arun Balakumaran; Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA; Medical University of Innsbruck, Innsbruck, Austria; Irmandade da Santa Casa de Misericordia de São Paulo, São Paulo, Brazil; The Alfred Hospital, Melbourne, Australia; City Hospital #31, Saint Petersburg, Russia; Hôpital Claude Huriez, Lille, France; Mayo Clinic, Scottsdale, AZ; Indiana University School of Medicine, Indianapolis, IN; University of Athens School of Medicine, Alexandra General Hospital, Athens, Greece; Amgen, Inc., Thousand Oaks, CA
Background: Denosumab (dmab) is a fully human monoclonal antibody against RANKL and is superior to ZA in preventing skeletal-related events (SREs) as shown in 3 identically designed phase 3 trials (N=5723). Overall survival (OS) was balanced between treatment groups in the overall study populations of these trials. In the trial of patients (pts) with solid tumors (excluding breast and prostate) and multiple myeloma (MM), OS was longer for dmab pts with lung cancer, shorter for pts with MM, and balanced for pts with other solid tumors. This analysis further characterizes the results from the MM subset of this trial.
Methods: Pts with solid tumors or MM were randomized (1:1) to receive 120 mg of SC dmab or 4 mg of IV ZA Q4W. Daily calcium and vit D supplements were strongly recommended. The primary endpoint was the time to first on-study SRE; results from the primary endpoint and lung cancer subset were previously reported.
Results: Of 1776 randomized pts, 10% had MM (93 ZA, 87 dmab). OS favored ZA (hazard ratio: 2.26; 10 subject difference in deaths). 1-year OS was 83% dmab, 97% ZA. Imbalances in baseline prognostic characteristics were observed. More pts in the dmab arm had low baseline renal function (CrCl < 40 mL/min) (ZA 2 [2%], dmab 9 [10%]) and more ZA pts underwent stem cell transplant (ZA 23 [25%], dmab 15 [17%]). Additionally, more ZA pts had stage I tumors at diagnosis (ZA 13 [14%], dmab 9 [10%]) and better performance status (ECOG = 0; ZA 30 [32%], dmab 21 [24%]). Study discontinuations due to consent withdrawal or lost to follow-up were also higher in the ZA group (ZA 17 [18%], dmab 11 [13%]) and occurred earlier in the ZA arm (ZA 59%, dmab 45% within 9 months of randomization).
Conclusions: In this SRE study of dmab vs ZA, pts were stratified by baseline characteristics known to affect SRE outcomes, but not by prognostic factors or concurrent anticancer therapy that may impact survival in MM. OS results in the MM cohort are difficult to interpret due to small sample size and imbalances in baseline disease characteristics, stem cell transplant therapy, and consent withdrawal or loss of follow-up that favored ZA. A phase 3 trial is currently underway, which controls for these factors in pts with MM.
Clinical trial information: NCT00330759
Ken Anderson, MD
Dana Farber Cancer Institute
Boston, Massachusetts, USA
Sundar Jagannath, MD
Mount Sinai Medical Center
New York, New York, USA
Shaji Kumar, MD
Mayo Clinic
Rochester, Minnesota, USA
Sagar Lonial, MD
Emory University School of Medicine
Atlanta, Georgia, USA
Paul Richardson, MD
Dana-Farber Cancer Institute
Boston, Massachusetts, USA
Saad Usmani, MD, FACP
Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences
Little Rock, Arkansa, USA
Ajay Nooka, MD, MPH, FACP
Winship Cancer Institute of Emory University
Atlanta, Georgia, USA
Katja Weisel, MD
University Hospital Tuebingen
Tuebingen, Germany
Andrzej Jakubowiak, MD
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, USA
Antonio Palumbio, MD
University Of Turin
Turin, Italy
Irene M. Ghobrial, MD
Dana-Farber Cancer Institute
Boston, MA
Henk M. Lokhorst, MD
University Medical Center Utrecht
Utrecht, Netherlands
Member, IMF Board of Scientific Advisors
Shivlal Pandey, MD
Mayo Clinic
Rochester, Minnesota, USA


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10 facts on cholera
Reviewed February 2014
WHO/C.L. Chaignat
Cholera is an acute diarrhoeal infection caused by ingestion of food or water contaminated with the bacterium Vibrio cholerae O1 or O139. It is a global threat to public health and a key indicator of lack of social development. Recently, the re-emergence of cholera has been noted in parallel with the ever-increasing size of vulnerable populations living in unsanitary conditions.
This fact file presents 10 facts on cholera.
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When ones shit is popping out of ones ass but they keep squeezing it back inside so they dont take a poop.
Katie was prarie doggin it when she was at Lauren's house because she didnt want to stink out the bathroom.
додав Jenn 11 Квітня 2004
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Offer valid beginning August 27, 2014 through September 1, 2014 in abercrombie kids stores and online at abercrombiekids.com. Not valid outside the US and Canada, at the Flagship location in NYC, or at all abercrombie kids outlet locations. Offer not valid on Fragrance, Body Care, Girls Overalls, select Girls Outerwear, select Boys Sweaters and Jogger pants, and 3rd party merchandise under the 'Our Favorite Brands' category (Superga, Sugarlips, and Limited Edition Tees). Applies pre-tax and does not apply to gift cards, e-gift cards, gift wrapping or shipping & handling of discounted items. Cannot be applied to previous purchases. Cannot be used in combination with other offers or promo codes on the same items, or in combination with Associate Discount. Online price reflects discount. Discount will be applied in stores at checkout to all eligible items and will be deducted upon return of any item to which the discount was applied. Purchase quantities may be limited. Not redeemable for cash or credit. Other restrictions may apply. See below for a full list of stores where offer is unavailable.
alternate offer locations
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Offer valid beginning July 15, 2014 for a limited time on all approved orders equaling $75.00 or more placed online at our website, abercrombiekids.com. To qualify, orders must be shipped within the U.S. and Canada via Standard Ground service. Order total is calculated after all discounts and excludes Gift Cards, Electronic Gift Cards, Gift Wrap, taxes, and Shipping & Handling of discounted items. Discount will be taken automatically at checkout. Not valid on previous orders. Purchase quantities may be limited. Not redeemable for cash or store credit. Other restrictions may apply.


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Thank you for visiting our past auction result archives. If you have an item identical (or similar) to this auction lot, please call, write or contact us to discuss. We will be able to help you.
Lot # 909 (of 1560) < Previous Lot | Next Lot >
Seven 1975 Topps Mini Wax Cases (112 Boxes)
Starting Bid - $10,000, Sold For - $82,250
Group of seven original wax cases of 1975 Topps Mini baseball. Each wax case houses sixteen boxes with thirty-six packs per box for a total of 576 packs. With each pack containing ten cards, a single case represents a total of 5,760 cards. Therefore, these seven complete wax cases contain a total of 40,320 cards. The 1975 Topps Mini set includes the rookie cards of Hall of Famers George Brett, Robin Yount, and Gary Carter, and many other stars, including Schmidt, Aaron, Ryan, and Jackson. The 1975 Mini cards are 20% smaller than the standard Topps cards and were test marketed only in Michigan and certain areas of the West Coast. Aside from their smaller size, they are otherwise identical to the standard 1975 Topps cards. The colored flush-to-the-border design of the 1975 Topps Mini set makes this issue particularly challenging to collect in extremely high grade. While we cannot state with certainty, it seems highly probable that within these seven cases are numerous cards, both stars and commons, that would be ideal candidates for professional grading. The outer boxes, all of which display normal shipping wear, have been opened but the sixteen wax boxes in each case remain in their original unopened state. Also included with the cases are sixty extra packs, all featuring stars seen through the wax wrapper on top or bottom, including Brett and Yount rookies. As a special courtesy to REA, all unopened boxes and cases in this auction have been personally reviewed by world renowned unopened box and case expert Steve Hart of the Baseball Card Exchange. From the Charlie Conlon Collection. Please Note: Due to the size and/or weight of this lot, shipping costs (depending on where it is sent and its method of shipping) may be substantial. Reserve $10,000. Estimate (open). SOLD FOR $82,250
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Welcome to our weekly edition of what's hot in social media news. To help you stay up-to-date with social media, here are some of the news items that caught our attention.
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Young Scientists Club
Magnetism, Static Electricity, & Water Cycle Kit Set 9
- Color:
- multi
Qty: 1
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Description: A captivating collection of science experiments, this young scientist series of kits presents a number of imaginative activities. Shape magnetic fields, construct your own magna doodle, create real lightening sparks, capture a tornado in a bottle, and so much more with the three included kits - Magnetism; Static Electricity; and Tornadoes, Clouds, and Water Cycle.
- 3 complete kits in one box
- Award-winning science kits make science fun, educational, and hands-on
- Suitable for ages 5 to 12 years
Material: 100% Polyester
Brand: Young Scientists Club
Origin: Imported


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Sometimes it just takes a second to become famous, and this is exactly what happened to Russian ice dancers Ekaterina Rubleva and Ivan Shefer at the 2009 European Figure Skating Championships in Helsinki.
Sometimes it just takes a second to become famous, and this is exactly what happened to Russian ice dancers Ekaterina Rubleva and Ivan Shefer at the 2009 European Figure Skating Championships in Helsinki.
The whole world heard about that incident, it certainly gave them publicity!
Despite the issue with Ekaterina's costume, their CD was one of the best of the event, which I think is a great achievement as most of the CDs weren't very good.
Great article, written with warmth and good humor by Tatjana Flade.
These articles and interviews with skaters who don't usually get a lot of press are a great service. Thanks, gsk8.
Excellent article, well-written and interesting. I second what Mathman wrote about featuring skaters and teams who don't get tons of press.
I'm glad Ekaterina can now laugh off what happened at Euros. I'm sure we'll see her next season in a more durable costume . Best of luck to them - 15 years together, wow! I think only Del/Schoe have had a longer partnership of the current ice dance teams (Z/Z have apparently been skating together since 1995, V/M since 1997).
BTW, that Euros CD has over a million views on Youtube. That's likely about one million more than the second-most viewed. Are people that desparate to see breasts? Surely there's more graphic stuff online .
D&W are the longest paired dance team in the US, and they're also from 1997, so R&S have definitely been together longer than anyone in the US.
I loved this snippet from Rubleva about the difficulty of ice dance judging! I would have the same problem:
Both skaters finished their studies for the coaching diploma and are now focusing fully on their sport. Rubleva even passed the exam for a technical specialist in ice dance at the national level and has been judging domestic competitions.
"Now I understand how hard judging is," Rubleva sighed. "It is very difficult what is required from the judges and technical specialists. There is not much time when you have to look at everything - when you have to watch two people. Even when they split up during the footwork and one (specialist) is watching one partner and the other is watching the other partner - it is still very difficult. When I started judging, they told me that I need to focus and to watch only the elements. But I'm watching and then I get so drawn into the program that I forget about everything else. What elements? The others say, 'Katia, the elements are over.' I think it is very hard to focus only on the elements."
Last edited by dorispulaski; 05-03-2009 at 03:58 PM.


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Home > News > 2006 SMTA Pan Pacific Symposium
April 28th, 2005
2006 SMTA Pan Pacific Symposium
Sponsored by the SMTA, the Symposium focuses on the critical business markets and technologies of microelectronic packaging, interconnection, microsystems, nanotechnology, and assembly.
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HP ProDesk 400 Desktop PC - Intel Core i5-4670 3.40GHz, 8GB Memory, 1TB HDD, DVDRW, Windows 7/8.1 Pro 64-bit - G5Q79UT#ABAItem#: HPR-102336157 | Model#: G5Q79UT#ABA
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HP ProDesk 400 Core i5 1TB Desktop Product Details
HP ProDesk 400 Desktop PC
Get your business the HP ProDesk 400 Desktop PC. This PC has a 3.40GHz Intel Core i5-4670 processor with 8GB of DDR3 RAM to give you sufficient speed and memory to perform all your business related tasks. It also has a 1TB HDD to store all your valuable data. It comes with Windows 7 Professional 64-Bit pre installed and can be upgraded to Windows 8.1 Pro 64-Bit that runs all the popular business applications. It also has Integrated Graphics provides outstanding visual experiences. In addition, its DVDRW drive enables you to play or burn your CDs and DVDs anytime. Surf the web, social network site, play games online and much more with its Gigabit Ethernet LAN. This business desktop offers unmatched computational performance, reliability and scalability that take your business to a new height. Buy the HP ProDesk 400 Desktop PC today!
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A possible Democratic candidate for president in 2016 criticized Gov. Nikki Haley and other "tea party Republicans" for their "ideology of less" at a gathering of South Carolina Democrats in Charleston Saturday.
Maryland Gov. Martin O'Malley underscored the need for South Carolinians to help their state and the nation by unseating Haley next year and by electing Democratic candidate Elizabeth Colbert Busch to the 1st Congressional District seat in May.
Tim Pearson, a chief adviser to Haley, was quick to respond, questioning whether South Carolina voters share O'Malley's ideology. "I'm doubtful they do," Pearson said.
O'Malley was the keynote speaker at the South Carolina Democratic Party's second annual Issues Conference, held at West Ashley High School.
"In these challenging times, there's a clear contrast between leadership that actually works and ideology that doesn't," O'Malley said, emphasizing that the proof of good government is in the results.
"Now, some of these new tea party Republican governors are funny in this regard, aren't they? They run on a platform claiming government isn't working. Then when they're in office, their own failure to do the job proves their point.
"Your current governor — bless her heart — is a case in point. Creating jobs at Georgia's Port of Savannah instead of creating jobs at South Carolina's Port of Charleston, failing to take basic cyber security precautions to protect 3.6 million Social Security numbers, then waiting nearly two weeks to tell hundreds of thousands of South Carolinians that their credit card data had been hacked and stolen.
"How's all that working for South Carolina?"
O'Malley then noted that South Carolina's 8.7 percent unemployment rate is one of nation's highest, that the Palmetto State graduates a lower percentage of high school students than 47 other states, and that the state has the highest tuition and lowest state support for public colleges in the South.
"If this works for you and your family, if you think college is something that only rich families should be able to afford, perhaps you want to stick with Governor Haley. If you believe that every hard working kid in South Carolina deserves a fair shot at the opportunity to go to college, you want to work hard to elect a new governor like (S.C. Sen.) Vincent Sheheen."
Pearson gave a brief response to O'Malley's comments.
"Martin O'Malley is, predictably, juking the stats — unemployment has gone down in South Carolina since Nikki Haley took office, and gone up in Maryland since O'Malley took office," Pearson said.
"If (O'Malley) wants to be honest with South Carolinians, we're happy he's here. If not, he should go back to Maryland where he quite successfully legalized gambling, gay marriage, the end of the death penalty, and hiked taxes on everyone and everything he could think of.
"If the people of South Carolina want those same values, they should get behind Vince Sheheen and Martin O'Malley. I'm doubtful they do," said Pearson.
While O'Malley was trumpeting Sheheen, the state senator from Camden, who lost a bid for governor against Haley in 2010, has not yet committed to running again, but said he will be considering it in the months ahead.
On Saturday, Sheheen joined Rep. Leon Stavrinakis at the conference in a panel discussion on education and introduced his 110-page book, "The Right Way: Getting the Palmetto State Back on Track," that offers a plan for improving the state. The book is free and available on Sheheen's website.
"The book is not about me. It's about South Carolina. I call it a platform for policy and a revolt against the status quo because we need to change South Carolina. I drafted it to talk about substantive issues in a way that's not partisan," Sheheen said.
"The Right Way," he said, focuses on four key issues — public education, economic development and job growth, transportation, and restructuring and reforming state government.
"If economic development and lower unemployment rates are priorities, which they should be, then public education also has to be a priority. The states who succeed economically have good, thriving public education systems," said Sheheen, whose mother is a retired teacher and principal.
While O'Malley's speech was the highlight of the day, state Democrats immersed themselves in several issues Saturday, with other panel discussions on health care and Medicaid, unions, the voter identification law, rural issues, the environment and clean energy, women and young people in politics, social media, and fundraising and budgeting.
The organizer of the conference, S.C. Democratic Party First Vice Chairman Jaime Harrison, underscored the importance of Democrats in the state to start gearing up for a big year, and said O'Malley was just the man to set the fire.
"Again my friends, 2014 is an important year for us because our governorship is up," said Harrison, in his introduction of O'Malley. "If we're going to kick off the campaign to get rid of Nikki Haley and to do what we need to do in this state to protect to our voters, to protect the people that we love, then this is the man (O'Malley) I want to kick it off."
State Sen. Vincent Sheheen, D-Camden, (right) introduces his book, "The Right Way: Getting the Palmetto State Back on Track," during a panel discussion on education with Rep. Leon Stavrinakis, D-Charleston, on Saturday. David Quick/postandcourier.com×
Maryland Gov. Martin O'Malley gave the keynote address at Saturday's South Carolina Democratic Party Issues Conference at West Ashley High School. David Quick/postandcourier.com×
Maryland Gov. Martin O'Malley gave the keynote address at Saturday's South Carolina Democratic Party Issues Conference at West Ashley High School.×


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In the recent column, Perspectives (featuring editorials from other newspapers) concerning group homes and drug and alcohol clinics, I give the following response:
Every individual is responsible for his/her own actions. If the individuals don't care about themselves as well as the others around them, then why should society have to pay the price of their disrespect? Dumping billions of dollars into failed programs to give these people more chances makes no economic sense at all.
Unless, of course, you have people that view this misfortune of society as a cash crop. They can fill their own pockets with taxpayers' money and share some of it with judges, politicians and media who advocate these failed programs as long as there is something in it for them.
A better approach to this problem would be to take the position "if they don't care, why should we?" We should make these criminals and addicts pay dearly for their bad decisions and the new body of knowledge will be "everybody doesn't do it."
We have already taken this approach with alcohol and tobacco.
Group homes and drug clinics are, in reality, welfare at its worst. They are proven failures and make problems even worse.
The only reason they still exist is that they are cash cows. After 30-plus years of failure of these programs in our communities, the question becomes: "What does the Mirror consider these programs to be?"
James Thompson


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Directions Englewood, CO 80113
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Subaru Dealer in Denver, Colorado offering used Subaru cars and SUVs. Groove Subaru in Englewood is proud of the great prices and selection we offer our customers. You get peace of mind with our Clearway menu and our Pre-owned Protection. At Groove, it's not business as usual -- it's business your way.
Not only do we sell new and used cars, but Groove Subaru has exceptional auto repair and auto parts teams to help you keep your car running smoothly. If your vehicle needs maintenance, speak to one of our car repair and service pros today.
Tax, tags, registration, and insurance are an extra cost.
"Used Vehicles may be subject to unrepaired Manufacturer recalls. Please contact the Manufacturer for recall assistance/questions before purchasing or check the National Highway Traffic Safety Administration (NHTSA) website for current recall information at https://vinrcl.safercar.gov/vin/"
* Although every reasonable effort has been made to ensure the accuracy of the information contained on this site, absolute accuracy cannot be guaranteed. This site, and all information and materials appearing on it, are presented to the user "as is" without warranty of any kind, either express or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, title or non-infringement. All vehicles are subject to prior sale. Price does not include applicable tax, title, and license. Not responsible for typographical errors.


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Top Definition
A VERY HARD PENIS! Sometimes a girl will add sugar to enlighten a blow job
yo Paco did you give your girl some rock candy?
автор: Heat seeker! T.C.S 15 апреля 2008
Trending Now
Can you define these popular missing words?
A derogatory term for someone who is stubborn.
Guy 1: Everyone wants to see Shutter Island but you, John
John: No way dude, I wanna see Alice in Wonderland
Guy 1: Dude, quit being such a rock candy
John: No way dude, I wanna see Alice in Wonderland
Guy 1: Dude, quit being such a rock candy
автор: Three sheets to the wind 13 марта 2010
Rock Candy... a slang term made by Nympha n Nuda while covering up the meaning of the true word. Also see hard on.
Nympha- I was stradaling him.. n he got sum mad rock candy.. all i could think is how small...
Nuda- Haha.. that must have been sum small shit.
Nuda- Haha.. that must have been sum small shit.
автор: Nuda 6 мая 2004
The deposits that form on your pubes after working in hot weather also known as the salty furmundo chundo.
Dude, my dog totally went for my rock candy while I was sitting on the couch after work!!!
автор: Splinter1700 6 февраля 2010
Shatter a glass and roll penis in glass. Procede to shove glass-covered penis into girl's mouth, resembling a stick of rock candy
Caitlin requested a "rock candy" last night.
автор: McPida 5 марта 2005


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Serves 6 |
Prep Time 15 minutes |
Cook Time 1 hour 40 minutes
2 cups Eden Dried Black Beans
2 Tbsp Eden Extra Virgin Olive Oil
2 medium onions, chopped
3 cloves garlic, minced
1 medium jalapeno, seeded and diced
1 medium red, yellow or orange bell pepper, seeded and chopped
2 stalks celery, diced
1 Tbsp cumin powder
5 cups water
2 cups brewed coffee
2 whole bay leaves
1/4 cup Eden Bonito Flakes, crumbled, optional
1 tsp Eden Sea Salt
1/4 cup finely chopped scallions or parsley, for garnish
Sort, rinse and soak beans as box directs. Drain beans and discard soaking water. Heat oil in a soup pot and sauté the onions for 2 to 3 minutes. Add the garlic, jalapeno, bell pepper, celery, and cumin. Sauté about 5 minutes. Add soaked beans, water, brewed coffee and bay leaf. Bring to a boil, skim off any foam that rises to the surface, and reduce the flame to medium-low. Cover and simmer about 1 1/2 hours until the beans are tender. Remove the bay leaves and add the sea salt. Cover and simmer another 10 minutes. Serve soup garnished with chopped scallions and a dollop of plain organic yogurt or sour cream, if desired.
American, Beans, Condiments, Gluten-Free, Good/High Fiber, Good/High Protein, Japanese Food, Macrobiotic, Mexican/Spanish, No Sweetener Added, Oils, Soup, Chili & Stews, Wheat-Free


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UML with VS 2010 Part 9: Organizing and Managing Your Models
- Posted: Jul 28, 2010 at 1:04PM
- 4 comments
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In this screencast, Clint Edmonson wraps up the series with a discussion around organizing models in model explorer as a project progresses.
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Good stuff, Clint! Thanks for putting these videos together!
+1 on the Domain-Driven Design recommendation.
Will the samples you show in the videos be available for download? I'd love to play around with them in my own copy of VS 2010.
look at his blog http://www.notsotrivial.net - there are all the vs projects & ppt's for download available.
excellent series.
I would like to see the next step: implementation, so how to go from models to code.
I also would like to know if there is a relation with generating diagrams from code (VS supports view class diagram and generate sequence diagram from code). So basically I would like to know if there's roundtrip support within VS.
Thanks in advance
Comments have been closed since this content was published more than 30 days ago, but if you'd like to continue the conversation, please create a new thread in our Forums, or Contact Us and let us know.


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JACKSONVILLE, Fla. – The Stetson lacrosse team's inaugural season came to an end on Friday, as the third seeded Hatters (2-14) were defeated by second seeded Detroit (5-13) by a score of 21-7 in the semifinals of the Atlantic Sun Conference Championship in Jacksonville.
The Titans' Kylie Birney scored off of an assist from Tessa Keuler in the first minute of play which ignited an 8-2 run to start the game, and Detroit never looked back. After Stetson freshman and all-conference player Danielle Horgan tied the game at 1-1 just over four minutes into the game, A-Sun Player of the Year Zaynib Hamze countered with a pair of goals to quickly take the advantage back for the Titans.
Stetson freshman Maylis Broderick scored with 20:30 to play in the first half to keep the Hatters close, making it 3-2, but five straight scores, including two from Hamze, gave Detroit the considerable six goal advantage.
Horgan struck again, and freshman Paige Levesque scored twice to bring life back into the Stetson squad, making it 9-5 with just 7:42 to play in the period. Before the frame ended, however, Detroit scored four more to take a 13-5 lead into the break.
The second half proved to be uneventful, as the Titans outscored the Hatters 8-2 to cruise to the 21-7 victory, and advance to the first ever A-Sun Women's Lacrosse Championship game. Levesque and freshman Mary Kate O'Sullivan found the back of the net for Stetson in the second half.
Levesque led the Hatters with three goals and four draw controls. Horgan added two goals and two draw controls in the loss. Broderick and O'Sullivan, another all-conference honoree, each finished the day with one goal and one assist.
Freshman Melanie Fredericks also added an assist, while freshman Amanda Parker led Stetson with six ground balls and two caused turnovers. Freshmen Caili Guilday and Whitney Meyers split time in goal. The former made seven saves in 40 minutes, and the latter stopped one shot in 20 minutes between the pipes.
Stetson finished its inaugural season with an overall record of 2-14, after winning its final two contests of the regular season. The young Hatters squad will look to improve upon that mark next season.


text:
Wall Street Decline Takes Its Toll...
Developers of DTC Genetic Testing Are...
NSCLC is "Major Battlefield" as Merck,...
LC-MS Gains Favor Due To the...
RNA has emerged as one of the most fascinating molecules in biology. As the Human Genome Project revealed that the number of genes in humans, lower than predicted, is comparable to that from Arabidopsis thaliana and Caenorhabditis elegans, and alternative splicing together with complex combinatorial transcriptional regulation took center stage as fundamental mechanisms to diversify the proteome, significant resources started to focus on the previously so-called "junk DNA", which encompasses the majority of the human genome and is transcribed into noncoding RNA.
One class of these noncoding RNA molecules, microRNAs, recently emerged as key post-transcriptional regulators in physiological and pathological contexts.
"The work on this topic has been exciting and encouraging, and the field as a whole will be shaped as people understand the relationship between microRNAs and their targets," says Andrew Z. Fire, Ph.D., professor of pathology and genetics at Stanford University School of Medicine and co-recipient of the 2006 Nobel Prize in Physiology or Medicine.
One of the perceived challenges in studying microRNAs is that each microRNA can apparently regulate up to hundreds of target protein-coding genes, with each target gene potentially regulated by multiple different microRNAs. In this context, the almost 2,000 microRNAs described to date in humans, some of which are present at cellular concentrations that vary by four orders of magnitude, have been viewed as part of an extremely complex and dynamic network.
"The question about the relationship between microRNA molecules and their targets is one that frustrates everyone, as for certain microRNAs it is hard to identify and study their definitive targets, but for others these have been relatively well characterized, in terms of either a broad set of targets that are regulated at modest levels or a few targets that are regulated at substantial levels," explains Dr. Fire.
Either way, miRNAs are a key family of regulators, and understanding the source of diverse miRNA populations has become a critical part of understanding gene regulation. A recent project in Dr. Fire's lab tested whether microRNA molecules with no direct genome match could be produced by RNA splicing.
The investigators generated intron-interrupted variants of the Caenorhabditis elegans lin-4 gene, encoding the first microRNA molecule that was discovered and, almost two decades ago, shown to be essential for the temporal control of postembryonic development.
"The intron that we used is a typical intron that a typical mRNA would use," says Huibin Zhang, a recent Ph.D. graduate in genetics at Stanford University School of Medicine and lead author of the study.
The possibility of processing functional metazoan microRNAs by splicing an intron-interrupted precursor has multiple implications. One of them, the potential requirement for splicing for the in vivo biogenesis of certain microRNAs, would point toward an additional layer in the cellular gene expression regulatory networks.
"This also provides the ability to engineer a microRNA gene and track its expression a little more carefully, as it has to be spliced," says Dr. Fire. The involvement of splicing in microRNA biogenesis could also help better understand factors that shape splicing in various species.
"The $64,000 question remains the one of target specificity. Once people identify the targets and learn how specific microRNAs interact with them, a lot of things will move forward, and this includes learning why a microRNA could be synthesized with or without introns in terms of the information content involved," explains Dr. Fire.
Central features that distinguish the biology of RNA from that of DNA are the decreased stability and increased fragility and structural dynamics that characterize RNA. Proteins that bind RNA to form ribonucleoprotein complexes are indispensable for its stability, structure, and function, and play central roles in its remodeling, an aspect that historically has made RNA biology a more challenging field experimentally.
"Only 10 years ago very little was known about the interactions between proteins and RNA in live cells. Most biochemistry was done out of the cellular context using assembled complexes and reporter constructs, and we could only guess what is going on in live cells," says Jernej Ule, Ph.D., group leader at the Medical Research Council Laboratory of Molecular Biology.
Dr. Ule and colleagues originally developed a method known as CLIP (ultraviolet cross-linking and immunoprecipitation), which maps the RNA sites that directly contact proteins in vivo, on a genome-wide scale. Recently, Dr. Ule's research group developed a new approach, iCLIP (individual nucleotide-resolution CLIP). iCLIP is based on the fact that reverse transcription most often stops at the crosslink site, and therefore sequencing of the truncated cDNAs provides information at nucleotide resolution.
The investigators used iCLIP to examine the in vivo binding of heterogeneous nuclear ribonucleoprotein (hnRNP) particles to the nascent transcripts. Powered to provide information at the nucleotide-level resolution, iCLIP revealed that hnRNP C binds uridine tracts, but shows a decreased binding at splice sites, pointing toward its importance in maintaining splicing fidelity.
Understanding the biology of RNA-protein interactions is an area of clinical interest, as many disease-causing mutations interrupt the function of ribonucleoprotein particles and, in this context, a focus on coding as well as noncoding RNA will be crucial.
"It is now clear that a very large proportion of mutations occur in the noncoding regions of the genome, and on the other hand most studies that tried to find disease-causing mutations have focused on the coding parts of the genome," says Dr. Ule.
The structural and functional characterization of these regions will help define their involvement in disease. "In addition to the noncoding RNA molecules, even mRNAs contain noncoding regions, and all these harbor important regulatory sequences with relevance for disease," explains Dr. Ule. Focusing on noncoding RNA and its involvement in disease pathogenesis promises to fill an important gap in the field.
According to recent estimates, 35 million individuals globally have Alzheimer's disease, and over 4 million are newly diagnosed annually. Relatively little is known about the etiopathogenesis of neurodegenerative conditions in general, but over 90% of the patients do not appear to harbor inherited disease-causing mutations.
At the same time, an increasing body of data implicates the involvement of alternative splicing, which is implicated in many diseases. Estimates that at least 30% of disease-causing mutations affect splicing, together with the recent finding that over 95% of the multiexon human genes undergo alternative splicing, point toward the clinical importance of this process.
"The question that we wanted to ask is whether alternative splicing could be involved, and this was scarcely asked before, simply because the technology was not available," says Hermona Soreq, Ph.D., professor of molecular neurobiology at the Hebrew University of Jerusalem.
To gain insights into molecular changes that could shape the etiopathogenesis of Alzheimer's disease, Dr. Soreq and colleagues used a technology that specifically interrogates alternative splicing, and comparatively examined transcripts from the cortical region of the brain in individuals with this condition and in matched control adults. In addition to finding genes whose expression was upregulated or downregulated, the investigators made an additional discovery.
"We found that the RNAs for approximately 400 genes were neither up- nor downregulated, but that their composition was changed by alternative splicing," reveals Dr. Soreq. Approaches that only measure gene expression levels would not have captured this set of genes. In most instances, the changes did not occur randomly but reflected the inclusion of a gene fragment that was not expressed in the normal brain, as a result of modifications in a family of heteronuclear ribonucleoproteins that function as splicing regulators.
By using biochemical approaches in brain sections, Dr. Soreq and colleagues revealed that these proteins were missing. This was accompanied by corresponding changes in the recently discovered family of regulator microRNAs, and the changes were very specific for Alzheimer's disease, as they were not detected in patients with other conditions such as Parkinson's disease or epilepsy.
Mimicking this modification in cultured neurons led to a loss of synapses, and the same changes introduced into the brains of live mice led to impairments in their learning capacities. "Altogether, these findings are pointing toward a new candidate for therapeutics that nobody knew about before," emphasizes Dr. Soreq.
"Several years ago, we made the interesting finding that a large fraction of alternative transcripts in human cells are not translated to proteins but, instead, have early stop codons that should target them for degradation by nonsense-mediated mRNA decay," says Steven E. Brenner, Ph.D., professor of plant and molecular biology at the University of California, Berkeley.
Nonsense-mediated mRNA decay, an mRNA surveillance pathway, is a quality-control mechanism described in all eukaryotes studied to date that was once thought to predominantly function to selectively degrade mRNA molecules harboring premature stop codons, to prevent the expression of truncated proteins. However, as Dr. Brenner and colleagues revealed, a large number of natural isoforms are also targets for this pathway. "We are trying to understand why it is that our cells are making thousands of these alternative transcripts that only get degraded," explains Dr. Brenner.
While examining the human genes that encode SR splicing regulators, a family of structurally and phylogenetically related positive regulators of constitutive alternative splicing, Dr. Brenner and colleagues found that all the family members were alternatively spliced. In several of these, the alternatively spliced forms harbored highly conserved elements within "poison cassette exons", which contain premature in-frame stop codons. Genes encoding other SR family members were undergoing alternative splicing in their 3' untranslated regions. These changes were predicted to target the respective mRNA molecules for degradation via the nonsense-mediated mRNA decay pathway. These unproductive splicing events were also described in the mouse orthologues of the respective human genes, and a distinguishing feature of the alternatively spliced elements is that they are among the most highly conserved regions between the human and the mouse genomes. "It is still a mystery what accounts for such an exceptionally high level of conservation, beyond the fact that we know that it is spatially associated with the splicing that causes the transcript to be degraded," says Dr. Brenner.
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text:
Celebrating 50 Years and More!
Upon their 50th Reunion, Mary Baldwin alumnae join the ranks of the Grafton Society — those members who have the longest ties to the college and have for many years been part of its incredible growth. Each year during Reunion Weekend, Mary Baldwin hosts a special induction ceremony on campus for those celebrating their 50th Reunion. Each new member receives a Grafton Society Medallion, which they are encouraged to wear to future college functions.


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MomLogic.com is teaming up with Trista and Ryan Sutter to throw their son Max his first b-day bash, and I was excited to be asked to help style the event! Even better, MomLogic is asking readers to help plan the party too – by voting on certain elements to select what will actually be used!
So for the first element of the party – the invitation – I designed 3 options that match the party's "Candyland" theme. You can vote for which design you like best, and whichever design gets the most votes is the one that Trista & Ryan will send out. The 3 options are below (click to zoom), and you can vote here …we'd love to get your input!
Option A:
Option B:
Option C:
Comments 48
- July 14, 2008 by jennifer
- tags:
- Candyland
- Max Sutter
- posted in:
- In the Spotlight
1CarrieO SAYS:
Option B
2Melissa H. SAYS:
So cute! I threw a Candyland party for my daughter's 3rd birthday. It was so fun and easy to do! We held it at the Water Conservation Garden in Cuyamaca College and used their pathways for a real-life candy land game. I have some pics on my (not-so-updated) blog : http://iamleese.blogspot.com/2007/12/myas-candyland-birthday-result.html
3amy SAYS:
A) This is awesome. Congrats.
B) Can't decide. Too hard. 1 or 2 though. Let me pop over to the website and cast my confused vote.
C) Again. Awesome. So excited for you.
4neige SAYS:
I really like..no love all three
However I think option #3 is the bestest for a first bday. Its Cute! It fits with the theme! I just adore the lil gingerbread guy…oooo…scrumptious!!
#THREE for me!
5Jenn SAYS:
Thanks, everyone!
Melissa H. – your party is super cute! Thanks so much for the inspiration!
6Melissa at MasterPiece Weddings SAYS:
How stinkin' fun is this!!
7laughing808 SAYS:
option C
8Naomi SAYS:
I think 3 looks the most like an invitation. #1 is cute but looks like an ad.
9Heather C. SAYS:
I voted at MomLogic for Option A. So cute!
10maritessb SAYS:
i'm going to be the minority in this one. i like 1
11Soulful Girl SAYS:
I love option B
12Ericka SAYS:
Love all of them, but #2 gets my vote!
13One Chic Mama SAYS:
I love Option B. These are so cute, I'm sure the party will be one to remember.
14Kim O. SAYS:
Way to go HWTM! I can't decide between 1 or 2!!! They are way too cute:-)
15happyathome SAYS:
I think B has the focus on the birthday, as much as I love the candy tree. Great ideas!
FYI, watch for my new blog design being intoduced the week, it is nicey nice!
16Hilary SAYS:
I love B, definitely the best!
17Brenda SAYS:
I like option C the best as it looks the most birthdayish – but I wish it has the day of the week (Saturday) above the date like the other 2 invitations.
18Mimi SAYS:
Option B!!!
19Michelle @ Everyday Celebrating SAYS:
B! by FAR!
20Melissa SAYS:
I love the simplicity and design of A! These are awesome. :)


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Hoard's Dairyman: Photoperiod won't hinder or help good colostrum
Photoperiod won't hinder or help good colostrum
To get their best start, calves should consume high-quality colostrum as soon as possible after birth. High-quality colostrum isn't always an automatic from all dams though. Photoperiod during the dry period and how it relates to high-quality colostrum was the focus of a University of Illinois study. Results were published in the August 2010 issue of the Journal of the American Veterinary Medical Association.
Eighty-one Holstein cows were assigned to multiple photoperiod lengths: natural day length, long days (16 hours), or short days (8 hours) for the entire dry period. At calving, colostrum samples were taken hourly following birth. Results found that colostrum immunoglobulin concentration decreased by 3.7 percent during each subsequent hour after calving. They also found that the amount of time between calving and first milking as it relates to volume of colostrum produced was significantly and negatively related to colostrum immunoglobulin concentration. Finally, photoperiod showed no affect on either volume of colostrum produced or immunoglobulin concentration.