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Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
Wall Street Decline Takes Its Toll...
NSCLC is "Major Battlefield" as Merck,...
While lacking in some regards, the presidential commission report does offer a valuable step toward eventual regulation of genomic data gathering and use to ensure patient privacy. [© drizzd - Fotolia.com]
The Presidential Commission for the Study of Bioethical Issues took one small step for protecting genomic privacy with its release Thursday of the report Privacy and Progress in Whole-Genome Sequencing—but not the giant leap that the issue deserves.
One can hardly argue with the conclusions of the 140-page report, which the advisory panel has presented to the Obama administration. The commission spent much of this year wrestling with many of the issues arising from the falling price—and resulting potential for increased use—of whole-genome sequencing in clinical care, hoping to strike the right balance between researchers' use of such data and the privacy of individuals whose genomes are under study.
There's little that's objectionable in many of the recommendations, which are sound policy priorities such as improving data security and access, and creating a fully informed consent process. Also unarguable is the observation that widespread public participation and individual willingness to share genomic data and relevant medical information will be needed in order to realize the promise held by whole-genome sequencing for aiding in drug development.
And the report is also right in pointing out that while patients' genomes are the same whether sequenced in a doctor's office or a research lab, privacy standards for each setting now differ greatly. The former is covered by the Health Insurance Portability and Accountability Act; the latter, by the federal "Common Rule" or Federal Policy for the Protection of Human Subjects.
However, the report's 12 recommendations do not include a framework or guidance for implementing those fine recommendations through a measure that would balance researcher and patient interests yet protect genomic privacy. While beyond its charge of broadly examining "questions related to privacy and data access and the balancing of individual and societal interests," according to its request for comments issued in March, the report's lack of an implementation framework will require federal and state officials to address the issue themselves sometime in the future.
Such guidance is needed because, as the report notes, only about half the U.S. states offer protections against surreptitious commercial testing. Those protections vary among states: It is legal in many states, the report says, to pick up a discarded coffee cup and send a saliva sample to a commercial sequencing facility to discover an individual's predisposition to, say, neurodegenerative disease. That data could be misused, the report correctly warns, by a contentious spouse as evidence of unfitness to parent in a custody case.
"I don't know that that's the most significant risk in the real world, but it's definitely evocative of the problem. You don't want to be afraid that you can't touch anything or leave any of yourself behind without some snoop coming around and then learning everything about your genetic destiny," Jonathan D.J. Loeb, Ph.D., a partner in the law firm Dechert, told GEN.
Instead, the report recommends only that the federal and state governments develop a process for hammering out "a consistent floor of protections" covering whole-genome sequence data regardless of how they were obtained. These policies, the commission said, should protect individual privacy by prohibiting unauthorized whole genome sequencing without the consent of the individual whose sample is being examined.
"What we envision is a group consisting of federal and state experts and members of the informed public coming together, and determining how to get a consistent baseline most efficiently and effectively," said Amy Gutmann, Ph.D., commission chair and president of the University of Pennsylvania, answering a GEN question during a briefing for reporters.
She said that can be accomplished either through federal law or a patchwork of state laws.
"It's our job as a commission to ask the federal and state governments to step up to the plate and make sure it happens, and inform the public of the need for it to happen," Dr. Gutmann added. "We are not a legislative body."
Typically, federal funding of clinical or research work serves as a trigger for applying federal standards, while state standards fill in all the gaps, "or are sometimes free to be more rigorous than the federal standards," Stephen Latham, Ph.D., director of the Yale Interdisciplinary Center for Bioethics, told GEN.
However, genomic privacy can be an instance where Washington can influence the states by using its agency expertise and information gathering to make recommendations about laws.
"State legislators are going to be looking at this and saying, 'Wow we haven't really thought about some of these issues, and we need to address them."
Dr. Latham said it would have been more than impractical for the commission to address them directly given the numerous issues involved. Those issues include addressing genomic data for use in clinical intervention and for storage toward future research, as well as both federal and private uses of that data: "It would be impossible in a report like this to really give strong ground-level recommendations for laws or the content for consent forms."
Nevertheless, he added, the presidential commission report offered a valuable step toward eventual regulation of genomic data gathering and use to ensure patient privacy.
"It is a very helpful goad to action. It says a lot of very sensible and very general things about informed consent, data privacy, and data security. These things need to be said because we are hurtling toward the $1,000 genome, and we don't have basic legal standards in place to control the gathering and use of that information," Dr. Latham said.
The presidential commission gives future drafters of genomic privacy laws many of the elements that should appear in any eventual measure, by applying five ethical principles developed for its first report, New Directions: The Ethics of Synthetic Biology and Emerging Technologies, toward the ethics of whole genome sequencing:
The five principles follow from respect for persons, which as applied by the commission to genomic privacy requires that any collection and sharing of individual data be based on a "robust" process of informed consent.
"Laws and regulations cannot do all of the work necessary to provide sufficient privacy protections for whole-genome sequence data," the presidential commission concluded.
The U.K. thinks otherwise, having launched a five-year Genome Ethics survey designed to gather empirical data to guide policymakers. The Wellcome Trust Sanger Institute and research partners are questioning healthcare professionals and patients as part of the broader Deciphering Developmental Disorders (DDD) Study, a collaboration of Sanger and the U.K.'s 23 regional clinical genetics centers.
Dr. Gutmann noted the difference between the U.K. and U.S., where states traditionally shared power with the federal government. Then again, that hasn't stopped Washington from asserting policy primacy over the states on issues it deems urgent, such as implementing President Obama's Affordable Care Act, a measure that 26 states sued unsuccessfully to stop.
Where genomic privacy is concerned, however, the scale of data networks, research collaborations and round-the-world science cry out for federal leadership, no matter who wins election next month.
[Read the report here.]
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Top Definition
1. Used to describe something that is awesome, cool, amazing, fantastic etc. 2. Used as an exclamation.
Person 1: Want to come over to my place for beer and pizza?
Person 2: For sure. Rad Whales!
Person 2: For sure. Rad Whales!
מאת soilduck 3 באוגוסט, 2009
Trending Now
Can you define these popular missing words?

subset: commoncrawl


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Costco's New Return Policy – Not As Incredible
|Email Print
You knew it was going to happen, especially if you read about some of the abuses committed by commenters in my post about how incredible the former Costco return policy was. Well, Costco this week announced (Consumerist broke it, at least to me) that they were going to be adjusting the policy to a 90-day electronics returns policy on D24 categories (their categories) televisions, computers, cameras, camcorders, iPod/MP3 players, and cellular phones. This only applies to purchases made after the roll out date (explained below).
Concierge & Warranty Extension
One cool thing out of this is that I didn't know was that Costco extends a manufacturer's warranty on televisions and computers to 2 years from date of purchase and that they offer free technical support on their Costco Concierge Technical Support line available at 1-866-861-0450.
Roll Out Date
The policy is being rolled out starting 2/26 and ending 4/2 so if you make a purchase before the official roll out date you are grandfathered into the existing return policy. The dates are:
- California – 2/26/07
- Remaining West Coast incl. NW, LA, SD – 3/12/07
- MW and TX – 3/19/07
- SE and PR – 4/2/07
I assume that NW means Northwest, MW is Midwest, NE is New England, SE is Southeast, and PR is Puerto Rico.{ 111 comments, please add your thoughts now! }


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Behind a 55-point second-half scoring effort, the Stetson University women's basketball team rolled to 90-74 victory over Indiana State in the Hatters' home opener Monday night at the Edmunds Center.
Sasha Sims led five Hatters (2-2) in double figures with 24 points. Brianti Saunders and Cherisse Burris added 15 points apiece, while Jama Sharp scored 13 and C.J. Coddington netted a career-high 12.
Stetson played with a lot more intensity Monday after committing 26 turnovers in Saturday's loss to North Carolina A&T. The Hatters turned it over only 15 times against Indiana State (2-2), but grabbed 13 steals and converted 12 fastbreak points.
"We played a lot better and a lot more in sync," Stetson head coach Lynn Bria said. "Indiana State is a good team and they are well-coached. We knew we had to play well. We had a lot of good energy today. I thought we handled their pressure really well."
The Hatters also reached 90 points for the first time this season and shot 47.5% from the floor.
"Our players share the ball well," Bria said. They find the open person. They don't care who scores. We moved the ball well and we found the open man. When they went to a zone defense we knocked down some open shots."
The Hatters built an early 17-11 lead after Saunders picked the pocket of an Indiana State player and rifled the ball ahead to Coddington who finished a fastbreak lay-up.
Minutes later, Coddington picked off a pass and took it the length of the court for another lay-up to give Stetson a 24-17 lead.
The Hatters extended the lead to 14 in the second half on Sasha Sims's three-pointer at the 15:21 mark, but Indiana State kept the score close. On three separate occasions the Sycamores pulled with six points, but with under six minutes to play, the Hatters went on a decisive 7-0 run to pull away for good. A runner in the lane by Sharp and a three-pointer from the top of the key by Saunders highlighted the rally.
"We knew they were not going to go away," Bria said. "I was happy how we responded. We didn't fold, we started missing some free throws but we didn't hang our heads. We got stops when we needed to when we weren't scoring."
Stetson outrebounded Indiana State 48-36. Amber Porter led the effort with a season-high 10 rebounds. Burris added nine boards and Coddington had seven.
"This is probably one of our best rebounding efforts since I have been at Stetson," Bria said.
The Hatters have now won 19 of their last 20 and 31 of their last 33 games at home. However, Stetson will not see the Edmunds Center again until Dec. 5. The team's next three games are on the road, beginning Wednesday night at Volusia County rival Bethune-Cookman. Tip-off is slated for 7 p.m.
Notes: Sasha Sims has led the team in scoring all four games. She was 11-for-13 from the free throw line and went over 1200 points for her career ... Jama Sharp has recorded six or more assists in all four games ... Stetson unveiled its 2013 A-Sun Championship banner before the game.


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on April 19, 2013 - 12:20 AM
, updated April 19, 2013 at 5:28 PM
City residents vying for seats on the Buffalo School Board offered varied opinions on topics from the efficacy of charter schools to the performance of Superintendent Pamela Brown during a turgid but still tense candidates forum Thursday in the Burchfield Penney Art Center.
The two-hour forum, sponsored by the Buffalo Association of Black Journalists, was mostly devoid of overt attacks on the current members of the School Board. That is, until West District candidate James Sampson, responding to a question about Brown's performance as superintendent, turned the query around to shine a light on the performance of the current board.
"I think that Dr. Brown is doing a good job. She's obviously very well qualified," said Sampson.
"Too often we try to put the responsibility on one individual when I think we have to ask the question: Is the board doing their job? And I would suggest they're not, and that's why we've got so much interest in this race," he added.
Ten of the 14 announced candidates vying for six district seats on the nine-member board showed up for Thursday's forum. During her two-minute introductory remarks, Ferry District School Board member Sharon Belton-Cottman alluded to the challenges of the job.
"You have to have a passion to sit on the Board of Education … but the criticisms are harsh," Belton-Cotton said.
"For some reason, everyday citizens are expected to fix the problems that exist inside the homes of the children," she added.
All of the candidates offered their individual prescriptions for improving the academic outcomes of students in the district while working to better allocate resources and improve student attendance that all sounded vaguely similar.
Members of the School Board, including Belton-Cottman, Central District member and board President Mary Ruth Kapsiak and West District member Ralph Hernandez, were uniformly against charter schools, which they all described as a liability for the district.
"For those that feel that charter schools are the cat's meow, guess what? We're getting the children back on a regular basis that are not successful in the charter schools. They do not have the proper programs for children with learning disabilities," said Belton-Cottman.
"Obviously, as a trustee of a charter school, I think they are great assets," said Sampson, who sits on the board of at least one local charter school.
Other candidates participating in Thursday's forum were Bryon McIntyre and Joseph Mascia, Central District candidates; Theresa Harris-Tigg, an East District candidate; Wendy Mistretta and Sue Gillick, both candidates for the North District seat; Adrian Harris, a Park District candidate.
email: firstname.lastname@example.com


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Systemwide Events Calendar
2013 ACM AwardsApril 27, 6:00pm - 11:00pm
Manoa Campus, Art Auditorium
Come to the movies and vote for the best student films from the Academy for Creative Media! Vote for your "audience favorite" award! Come early for the reception. Two Showcase Screenings at 6 p.m. on April 26 & 27. Awards Ceremony at 6 p.m., Friday May 3. Complimentary pupus will be served. This event is free and open to the public. Supported by the SAFC (Student Athletic Fee Committee).
Ticket Information
Free to the public
Event Sponsor
Academy for Creative Media, Manoa Campus
More Information
Lily Ching, (808) 956-7736, email@example.com, http://acm.hawaii.edu/
|Saturday, April 27
|The Wellness Center - Fitness Class Schedule
Maui Campus, Pilina Bldg., Wellness Center
|Writing Retreat
Windward Campus, Hale 'Ākoakoa 107/109
|UHM Preservation Week
Manoa Campus, Hamilton Library Lobby
|2013 ACM Awards
Manoa Campus, Art Auditorium
|UH Cello Ensemble
Manoa Campus, Orvis Auditorium
|Spring Footholds
Manoa Campus, Prime Time in the Earle Ernst Lab Theatre
- Highlighted dates have scheduled events.
- Select the date to view all events for that day.


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My husband and I are spending this New Year's Eve at home. We have just returned from a week long visit with our oldest daughter out in Hawaii. Although I love visiting with my daughter, the flight to and from is quite wearing. To top it off, we both have caught a nasty cold. So, it looks as though we will be spending these next days on the mend.....that and doing laundry. ha ha. . .
What are you doing thisNew Year's Eve?
Thank you for stopping by
Have a beautiful day


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Nagorniuk & Kovalenko
Into rhumba. Much, much better than last couple
twizzles. level 1 he steps out of first one
Love Story with a rhumba beat synched in
circular step
second rhumba
lift - she stands on his leg
samba stuff
to end pose
Position After 2 Of 11
1. Anna NAGORNYUK/Viktor KOVALENKO (UZB) - 39.93 (TES: 21.49, PCS: 18.44)
2. Cortney MANSOUR/Daryn ZHUNUSSOV (KAZ) - 25.53 (TES: 13.22, PCS: 13.31, DED: 1.00)
Lol if I hadn't seen their names on screen, I would have thought that the mexican team was Tessa and Scott from their outfits.
I LOVE the song the Mexicans are ice dancing to now... so cool..
Ooops. I answered you too quickly. You must have edited your post. Anyways, happy for you.
Last edited by Violet Bliss; 02-11-2012 at 05:51 PM.
Bruhns & Van Natten
Rhumba music
Not a good first pattern, from a key point standpoint
into the lift, she's a plank over his knee, but with one leg wrapped around his leg
(I like this lift)
Music is a good fit for this
second pattern
seemed a little better
jump into twizzles, sort of done, they don't step or into it in unison.
circular step
Next 4 teams warming up.
Position After 3 Of 11
1. Anna NAGORNYUK/Viktor KOVALENKO (UZB) - 39.93 (TES: 21.49, PCS: 18.44)
2. Corenne BRUHNS/Ryan VAN NATTEN (MEX) - 35.93 (TES: 20.64, PCS: 15.29)
3. Cortney MANSOUR/Daryn ZHUNUSSOV (KAZ) - 25.53 (TES: 13.22, PCS: 13.31, DED: 1.00)
Anyone else scared for Paul/Islam, knowing their relatively undertrained status and the punishing altitude?
I wish the Shibutanis would be skating to something like Mana as that Mexican team did.
The Uzbekistan team's Love Story song was the worst. WHY do we have to encounter that awful piece of music even here? And they used an abrupt and awkward tempo slowdown just to launch into their second rumba sequence. My ears are bleeding.
Anyone know who O'Brien/Merriman are training with now (which coaches)? Their twizzles a minute ago in warmup looked good.


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Top Definition
A term coined by African hiphop artists especially rappers in the 21st century which signifies the mixture of conventional rap with high live beat, fuji, pidgin english and in some cases native languages.
Afro hiphop is well accepted with leke david who finds rap songs with their quite confusing.
מאת Leke david 23 בנובמבר, 2006
Trending Now
Can you define these popular missing words?


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by Andi Dwyer, Director of Health Promotion
A few weeks ago at the American Society of Clinical Oncology meeting, prevention was a hot topic! The news of prevention and exploring opportunities for early detection was extremely interesting. Before the next ASCO meeting, I have high hopes that we all can identify ways to bring early detection and prevention, for not just us, but others as well. My contribution – I need to lose some weight!
Skinnier & Wealthier
Speakers and presenters at the ASCO meeting noted that the impact of obesity on cancer is an initiative and priority. It is estimated that one-third of all adults and 17 percent of children are obese within the United States.
While the ramifications for health are not fully understood, we do know that there is a link between obesity and cancer. ASCO meetings highlighted specific mechanisms and in colorectal cancer:
- If someone is obese at the time of diagnosis, they are at high risk of recurrence and mortality (based on those participating in trials for stage II and stage III colorectal cancer)
- In the uninsured population alone, from 2000 to 2005, there was a 490 percent increase in medical expenditures directly tied to obesity and cancer
Obesity is hitting us in the waistline… and the pocket… even when it comes to cancer.
Get Nutrition Resources:
- PearlPoint Nutrition Resources
- Meals to Heal – Fresh, nutritious meals for cancer patients
- Michael's Mission – Cooking Toward a Cure cookbook
Two areas related to colorectal cancer prevention were also discussed and had studies presented: genetic testing and screening.
Genetic Testing
The role of genetic testing for familial and hereditary cancers is quickly evolving with the development of the next generation of testing.
Genetic testing for survivors and family members might not only be limited to testing for one genetic mutation, we may now be able to check for several types of genes that have ramifications for clinical impact beyond a single cancer.
Dr. Stephen Gruber, director of the Norris Cancer Center at the University of Southern California in Los Angeles, California presented in-panel discussion and stated that:
For patients who have tested positive for Lynch/MSI, there may be a 3.5-7 percent chance that they may test positive for genetic mutations related to other cancer types.
Technology has now progressed so much that there are additional tests within these new panels that may be able to detect Lynch/MSI that were not previously available. It's best to speak with your doctor about how to move forward in this area. Ask!
Get Genetic Testing Resources:
- "Is cancer lurking in your family tree?" worksheet
- Video about Lynch Syndrome
- Webinar by Heather Hampel, genetics counselor
And alas, screening was also discussed. A study presented noted that with tailored intervention, African American patients with telephonic navigation were more apt to receive colorectal cancer screening. However, the increase in the group who received navigation versus those who did not was only a 14 percent difference. Both the control group and the navigated group had a screening rate of under 40 percent.
We know that certain groups are at the highest need for colorectal cancer screening, (the uninsured, certain races/ethnicities, family history and those who should be following screening guidelines for surveillance after a cancer diagnosis.) Of course, everyone 50 or older should also be screened if they are average risk.
But the point remains – there is still a huge opportunity to prevent colorectal cancer through screening. Talk to your doctor, know your risk or encourage a family member.
Screening Resources:
So – how are you going to prevent colorectal cancer?
Three to choose from, what'll it be? If you achieve a healthy weight, know your genetic risk and get screened, you'll be skinnier, wealthier and healthier.
I'll let you know how my weight loss goes by next ASCO.
Read Andi's previous ASCO recap
Need colorectal cancer resources? Check out the Guide in the Fight.


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William Arrowsmith's translation—a lively, modern, unexpurgated text—recaptures all the ribald humor of Petronius's picaresque satire. It tells the hilarious story of the pleasure-seeking adventures of an educated rogue, Encolpius, his handsome serving boy, Giton, and Ascyltus, who lusts after Giton—three impure pilgrims who live by their wits and other men's purses. The Satyricon unfailingly turns every weakness of the flesh, every foible of the mind, to laughter.
"William Arrowsmith's translation of The Satyricon meets the two fundamental requirements of the translator's art: perfect fidelity to the original and a vitality of style that tempts the reader to believe that the English version is not a translation.… A classic of literature."
—Allen Tate
"Arrowsmith's brilliant translation … at one stroke renders every other version obsolete."
—London Times Literary Supplement
Table of Contents
The Author and Date of the Satyricon
The Extent of the Work and the Plot
The Literary Qualities of the Satyricon
On the Text and Translation
The Satyricon
Dinner with Trimalshio
The Road to Croton
The Fragments and the Poems
List of Characters
Notes on the Satyricon
Notes on the Fragments and Poems
The Authorship and Date of the Apocolocyntosis
The Place of the Work in Seneca's Writings
The Literary Qualities of the Apocolocyntosis
On the Text and Translation
The Apocolocyntosis of the Divine Claudius
Notes on the Apocolocyntosis


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Link: Added by:
Parker's personal timeline, a place to collect and share things from Parker's life.
Created by Pds0303
on Aug 25, 2010
Last updated: 08/26/10 at 06:07 AM
Parker S. has no followers yet. Be the first one to
I want to rent a Lamborghini on my 25th birthday, because you are not allowed to rent cars until you are 25.
Get my license
I wanna get my first job when i'm 15.
Started my freshmen year of highschool
My family went up to Marble Head and went charter fishing, and lots more.
My recent trip to Yosemite valley and the west coast.
Me and my friend Spencer went up to Cedar point and rode almost all the roller coasters.
My baseball team won 1st place
Every year, my family gets together and celebrates Christmas.
First day of first grade


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0 Members and 1 Guest are viewing this topic.
I see your 2 examples do not have the last row of canes at the very bottom.
Would that help in narrowing the date of the piece?
... the 2 samples you list seem to have a solid blue color on the bottom. Mine has a spotted effect.
Page created in 0.64 seconds with 36 queries.


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on February 6, 2013 - 8:48 PM
A Dartmouth Avenue man remained in custody at the Erie County Holding Center Wednesday night, a day after he was arrested for allegedly lacerating a woman's throat with a trowel during an argument in a car on Grider Street near East Ferry Street.
Robert L. Patton, 47, was arrested by Officers Thomas Herbert and John Sullivan shortly after the incident at 7:20 p.m. Tuesday. He was charged with second-degree assault and criminal possession of a weapon for allegedly cutting the woman's neck and threatening to "cut deeper," according to a police document. The woman sought medical attention on her own after Patton's arrest.


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Update: Latest Apple TV update broke the Plex hack, here is how to fix it.
Last week we reported that Plex now runs on non-jailbroken Apple TV 2 and Apple TV 3 thanks to PlexConnect, a clever little hack that allows a fully-functional Plex client on non-jailbroken ATV2 and ATV3. We also posted a tutorial on how to get it working on your little black box using a Mac. Below is an installation guide for Windows XP, Vista, 7 and 8.


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An Empirical Analysis of the Strategic Use of Corporate Social Responsibility
Donald S. Siegel
University at Albany, SUNY
Donald F. Vitaliano
Rensselaer Polytechnic Institute (RPI) - Department of Economics
April 2006
Recent theories of the strategic use of corporate social responsibility (CSR) emphasize the role of information asymmetry and how CSR is likely to be matrixed into a firm's product differentiation strategy. A key empirical implication of these theories is that firms selling experience or credence goods and services are more likely to be socially responsible than firms selling search goods. Using firm-level data, we report evidence that is consistent with this hypothesis.
Number of Pages in PDF File: 25
Keywords: Corporate Social Responsibility (CSR), Search Goods, Experience Goods, Credence Goods
JEL Classification: M14, D21
Date posted: May 11, 2006
Suggested Citation
Contact Information
© 2016 Social Science Electronic Publishing, Inc. All Rights Reserved.
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Apologies for the down-time recently – although I wouldn't consider myself an extreme case of lazyholic, I do relapse into serious laziness on occasion (speaking of lazy, check out Recovering Lazyholic – Erin Hudson might be lazy but she blogs awesome stuff and her work is great too).
However the week starts well with some beautiful monochrome shots by Brittany Chavez. Enjoy
[peekaboo name="chavez"]
[peekaboo_content name="chavez"]


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Home theater receivers buying guide
Find the surround sound receiver that's right for you
Deia began her Crutchfield career in 2010, as a sales advisor in the Spanish/International department. Crutchfield's hands-on sales training quickly converted her interest in photography into a full-fledged hobby. After five years in sales advising customers on choosing the best A/V and camera gear for their needs, she is happy to share her knowledge and enthusiasm for top-notch gear as an A/V writer.
More from Deia Z.
In a Nutshell
Nothing beats surround sound for movies and TV – and surround sound starts with a home theater receiver. The job of a receiver is to process incoming audio and video signals and direct them to your TV and speakers.
Room size and number of source components are big factors to consider when shopping for a home theater receiver. You'll want to decide how many speakers you want in your home theater so you know how many channels you'll need. It's also important to choose a receiver with the right power output for your speakers.
Extra features like multi-room audio and video, and wireless music streaming through built-in Bluetooth or Wi-Fi expand the role of the receiver and can extend its reach beyond your living room.
The latest home theater receivers have decoding for Dolby Atmos and DTS:X, the most realistic surround sound formats available. They also come with built-in support for 4K video, so if you have a compatible Ultra HD TV you'll enjoy stunning picture quality to complement the immersive sound effects.
We'll walk you through all the ins and outs of finding the right home theater receiver for your needs. You can start by taking a look at our top-rated home theater receivers.
Full Story
The rumble of speeding cars behind you grows gradually louder, echoing off the surrounding buildings. A faded black hood edges into view on the left, the booming roar of its engine eclipsing the sound of wind whipping through your windows and a street full of honking horns. A sudden squeal of tires on the right signals a narrow miss as you clear the intersection, while the shriek of metal on metal tells you that the car on the left wasn't so lucky.
A home theater receiver is the key to truly immersive, movie theater-like entertainment at home. In addition to providing impressively detailed surround sound, today's surround sound receivers act as a connection hub for a huge variety of audio/video sources. This article will walk you through the basics of home theater receivers, and then offer guidance on choosing the right model for your home.
The basics: What is a receiver?
Three components in one – a preamplifier ("preamp"), a tuner, and an amplifier.
A receiver combines three components in one – a preamplifier, a tuner, and an amplifier. The preamp lets you select which source you'd like to listen to or watch. With today's receivers, that can mean anything from over-the-air radio broadcasts to the smartphone in your pocket.
The preamp section also processes incoming audio and video signals from all your different sources. Once upon a time, signal processing meant controls for bass, treble, balance, and loudness. But today's receivers can decode numerous surround sound formats, and feature a huge array of digital processing circuits designed to improve sound and picture quality.
Traditionally, the tuner section just let you enjoy over-the-air AM or FM broadcasts. Some of today's receivers no longer include an AM tuner, but many have added more modern music sources such as HD Radio™, satellite radio, and Internet radio. Many modern home theater receivers let you enjoy digital content from smartphones or other devices connected via USB, or from networked, DLNA-enabled computers and hard drives.
Some receivers also tap into popular online music services such as Pandora®, Rhapsody, and Spotify. Others feature wireless technologies like Apple AirPlay® and Bluetooth (a separate adapter may be required), allowing you to wirelessly stream music from compatible smartphones and other devices.
The amp's job is to create a visceral, exciting, and engaging soundtrack to match the on-screen video. You'll need a receiver with enough power to satisfy the speakers you've chosen and to really rock the room you're in.
What today's receivers can do
Connect to a wide world of entertainment sources
All of today's home theater receivers let you access attached components, such as a Blu-ray player, cable or satellite box, video game console, CD changer, etc. You can also tune into radio stations via the receiver's built-in tuner. For models that connect to a home network, this includes Internet radio stations.
Deliver detailed surround sound
If you're new to home theater, the wide array of surround sound options can seem a bit overwhelming. Don't worry, though — all of today's home theater receivers will let you enjoy surround sound with movies from Netflix®, TV shows stored on your DVR, video games, and more. Along with decoding Dolby® Digital and DTS® soundtracks found on DVDs, HDTV broadcasts, and other programming, all current home theater receivers can also handle Dolby® TrueHD and DTS-HD® Master Audio, two high-resolution surround options available on Blu-ray discs. Some receivers are also compatible with Dolby Atmos® and DTS:X soundtracks, which use overhead speakers to create a higher soundstage while placing audio "objects" more accurately in the listening space. See our article on surround sound formats and our surround sound formats chart for more info.
The five channels of amplification in a 5.1 surround sound system provide power to two front speakers, a center speaker, and two surround speakers. A powered subwoofer (the ".1") provides deep bass for realistic full-range sound.
A 5.1 receiver will have five channels of amplification and an unamplified subwoofer channel (subs are self-powered and therefore do not require amplification by your receiver). Some receivers include additional channels of amplification, and could support 7.1 or even 9.2 surround sound.
Improve your system's picture and sound
Because most of us don't have acoustically ideal living rooms, there are a lot of obstacles that can hamper a speaker's sound. For example, although an overstuffed armchair next to the end table may really tie the room together, it may also absorb too much sound from your back left speaker, muddying the surround sound.
Most new home theater receivers include automatic speaker calibration. Plug the included microphone (left) into the microphone input on the receiver's front panel (middle). The receiver plays test tones, then calibrates the signals it sends each speaker to better suit your room (right)
That's why most home theater receivers these days come with automatic speaker calibration. Just plug in the included external microphone and set it up in your favorite viewing and listening spots (some receivers can calibrate for six or more positions). The receiver sends full-range test tones to each speaker, listening for dips in frequency response, slight timing delays, and other audio imperfections. Then, the receiver calibrates the signals it sends to each speaker with the goal of achieving the type of sound you'd hear in a more acoustically ideal space. In the example above, a receiver with auto-calibration might play the back left speaker a little louder than the back right speaker in order to overcome the muffling effect of the armchair.
Check out our video about automatic speaker calibration for more info.
Better music playback
Most home theater receivers include special sound modes specifically for music listening. For example, stereo music modes allow you to listen to just the front two speakers and subwoofer. Modes such as Dolby Pro Logic IIx transform two-channel music into multi-channel surround sound. Some receivers also feature audio processing designed to improve the sound quality of MP3s and other compressed digital music.
If you plan to connect high-quality music sources, you may be interested in a higher-end model that takes extra steps to protect audio signal integrity. For example, some receivers have an audio-only mode that shuts off video circuits, minimizing potential sources of noise. Other models simply let you play the music in its original form, without applying any audio processing at all.
(A quick side note though: if you want really high-quality music playback, you may also want a separate, dedicated stereo music system. See our article on building a stereo music system for more info. Or check out our article about surround sound for a music lover for ideas on putting together a system that can do both.)
Razor-sharp picture
On the video front, some higher-end receivers offer sophisticated video processing to improve the image quality of all your sources, whether standard- or high-definition. These models can upscale analog content to 1080p or even 4K and can clean up a lot of the graininess and noise from compressed videos, such as those found on online video sites. The receiver calibrates each video source independently, so that each can look its best. As an added bonus, these receivers can send everything to your TV via a single HDMI cable.
How much receiver do I need?
Enough for your TV and your room
In our experience, a big picture calls for big sound. If you've invested in a 65" LCD or a 106" projection screen in a larger viewing room, then you'll want equally impactful sound – consider getting larger speakers and a more powerful receiver that's capable of driving them. On the other hand, if you've got a 46" screen in a medium-sized den, then smaller speakers and a lower-powered receiver are a fine option.
Enough for your speakers
When matching a receiver to a set of speakers, the main problem to avoid is having too little power. Using a receiver that is underpowered for the task may result in distorted sound, and puts you at risk of overheating your amp and damaging your speakers over time. Keep in mind though that all watts are not created equal. Some manufacturers employ more stringent testing standards than others. Look for full-bandwidth power ratings measured over the entire range of frequencies audible to human ears – 20 to 20,000 Hz. That's generally a more reliable indicator of quality amplification than ratings measured over a smaller frequency range (or those rated at just a single frequency).
You'll also want to check your speakers' sensitivity rating. Lower sensitivity ratings indicate power-hungry speakers that will require more "juice" from your receiver to produce the same volume as speakers with higher sensitivity ratings. See our speaker FAQ and glossary for more info.
Want more sonic punch? Look for high-current power
The dynamic peaks that help make movie soundtracks and music so exciting can impose intense short-term demands on a receiver. High-volume special effects like explosions or loud orchestral passages can quickly deplete a receiver's power reserves, resulting in sound that's flat and uninvolving. Models with high-current power are particularly well equipped to handle these challenges, reproducing dramatic surges of sound with more punch and greater fluidity than other receivers with similar wattage ratings.
How many channels of power do you need?
The answer to this question depends on how many speakers you'd like to connect, and how you'd like to connect them. Most surround sound systems have 5.1 channels — five speakers and a subwoofer — but many receivers these days support 7.1 channels.
So what could you do with those extra two channels? Most 7.1 receivers let you assign the additional two channels to suit your needs. For example, you could use them to power a pair of speakers in a second listening zone. Or, if you have a large room and want fuller surround sound, you could create a 7.1-channel surround sound system. Finally, some models let you assign those two channels to compatible floor-standing front left and right speakers (known as "bi-amping"), giving you a fuller, more detailed front soundstage. See our articles on powering your multi-room system, bi-amping your speakers, and surround sound speaker placement for more info.
A 5.1 receiver can provide full-bodied, immersive surround sound in small-to-medium sized rooms. If you're setting up a 5.1 system in a large room, consider a higher-powered receiver and larger speakers.
A 7.1 surround sound system is a great option for large rooms. The two additional back surround speakers provide more seamless surround effects.
If you're creating a large theater room, with multiple rows of seating, you may want to consider a 9.2 surround sound system. Back surround speakers ensure convincing surround effects. Depending on your receiver, you can use the two additional front speakers to add width or height to your front soundstage. Finally, an additional subwoofer (".2") ensures deep, room-filling bass.
Most 7- or 9-channel home theater receivers let you assign extra channels of power. For example, you could enjoy 5.1 surround sound in your main room, plus stereo music on your deck. Or, you may be able to bi-amp your front left and right speakers for punchier, more detailed sound.
Getting it all connected: inputs and outputs
If you're not already familiar with home audio/video connections, hooking up a home theater receiver can seem daunting. But you can get most of the way there by keeping one basic rule in mind: always use the highest-quality A/V connection available. In most cases, that means using HDMI. If the component you're connecting doesn't have HDMI, you can fall back on a combination of component video and optical or coaxial digital audio.
audio/video interconnects and setting up your receiver for more info.Read our articles on
Figuring out what you need
Start by making a list of the video and audio components you own or want to own. Beside each, note the type of connection(s) it calls for. This will help you determine how many and what types of inputs and wireless connections you'll need on your new receiver. You'll want to make sure it's got enough of each type of audio/video connection for your existing gear. Ideally, it'll give you a little room to grow, too.
For example, if you were using the sample chart below, you'd want a receiver with at least four HDMI inputs (and preferably extra to allow room to grow), two HDMI outputs, Apple AirPlay®, and a built-in HD Radio tuner. Print our blank component connection chart to figure out how many of each input and output you need on your new receiver.
Have it or want it
Connection types
HDMI with ARC ("audio return channel") for over-the-air broadcasts
HDMI or component video + stereo audio
Audio/Video sources
Blu-ray player
Xbox 360
Cable or satellite box
Apple TV
Over-the-air TV
(See "HDTV 1")
AirPlay (wireless audio), Bluetooth (wireless audio, adapter may be required), or compatible USB input
CD player
Optical or coaxial digital audio input, or stereo audio input
HD Radio
Tuner built into receiver, or can be added via proprietary connection
Phono input
Connecting your HDTV
Many receivers can convert analog video signals, such as those from the original Wii (or other devices connected by component video), and send them to your TV via HDMI. Receivers with video conversion won't improve the image quality of any analog sources. The main benefit is having just one cable running from your receiver to your HDTV. If you connect a Wii via component video (an analog connection) to a receiver without video conversion, you'll also have to run a component video cable to your TV and change the TV's input selection when, for example, you switch from your Blu-ray player to your Wii.
As discussed above, some receivers also feature video upconversion. In addition to giving you single-cable convenience, these models can enhance the quality of both standard- and high-definition video sources.
Connecting a second TV
If you'd like to connect a second HDTV, think about what you'd like to be able to watch on that TV, and pay close attention to a receiver's capabilities. Receivers that simply have a second HDMI output will play the same content on both TVs. If you want to be able to watch different content on each screen, look for receivers that have an "independent zone 2 HDMI output" (or similar phrasing).
Want multiple viewing areas at your next playoffs party? A receiver capable of sending video signals to two TVs simultaneously will give sports fans plenty of room to watch the action.
If you're looking at a receiver with an independent zone 2 HDMI output, also be aware that it may not be able to play all connected sources on the second TV. For example, many HDMI zone 2 outputs can't convert or upscale analog signals, which means that any sources connected by composite, S-video, or component video wouldn't be viewable on the second TV. One possible workaround is to use the receiver's component video output instead of zone 2 HDMI.
If you'd like help setting up a dual-TV system, read our article about multi-room video or give us a call at 1-888-955-6000.
Virtually all new home theater receivers are 3D-capable. Even if you don't have a 3D TV now, there's a good chance your next one will be 3D. But don't worry — with 3D-capable receivers and TVs, your regular 2D content will still look great.
Connecting your audio/video sources
Getting surround sound from over-the-air (OTA) broadcasts
There are a couple of ways you can get surround sound signals from your TV's tuner back to your receiver. Many newer home theater receivers and HDTVs include HDMI connections that support an audio return channel, or "ARC." ARC-capable HDMI connections can carry audio signals from the TV back to the receiver so that you can enjoy OTA broadcasts in full surround sound. If ARC isn't an option, many TVs include an optical digital audio output in order to get OTA surround signals to your receiver. See our article on connecting your HDTV for more info.
Some receivers let you stream music from a compatible smartphone or other device
Add flexibility to your system using wireless technologies
More and more receivers include technologies to wirelessly access content. Those with AirPlay or Bluetooth (an adapter may be required) can access music on compatible devices, while those with DLNA can often access music, videos, and photos. In addition to cutting down on cable clutter, these technologies can make your system more flexible. For example, say your friend comes over and wants to play you a cool new album they just bought. With an AirPlay-enabled receiver, they could play it through your system using their iPhone or iPod touch. See our article on AirPlay for more info.
Connecting a turntable
If your turntable has a built-in phono preamp, you'll be able to connect it to any receiver via standard stereo audio cables. If it doesn't have a phono preamp, you'll need a receiver with a phono input, or you'll need to add a separate phono preamp between your turntable and receiver. See our article about turntables for more info.
Be aware of limited connectivity options in certain cases
Note that for some newer components, such as the Apple TV, HDMI may be the only video connection option. There may be workarounds – for example, sending video to your TV via HDMI and audio to your receiver via optical digital – but you'll lose some of the convenience and streamlined connectivity that today's receivers offer.
Also, if you're trying to connect older video components that don't have HDMI or component video connections, note that some newer receivers don't have S-video inputs. In that case, composite video may be your only option.
Should you set up your receiver for multi-room music?
If you're interested in building a multi-room music system, you've got a lot of options. To figure out what kind of system is best for you, consider what kind of content you'd like to listen to and how you'd like to listen to it.
Many audio video receivers can work as part of a multi-room music system. You may want to go with this more traditional type of multi-room system if you'd like to be able to listen to the sources connected to your receiver. For example, if you want to be able to listen to the game while you're grilling outside, installing a pair of outdoor speakers and connecting them to your home theater receiver may be the way to go. It's worth noting, however, that most receivers can only play sources connected via analog audio in the second listening area. One possible workaround is to make two audio connections from the same component: a digital connection for your main listening area, and an analog connection for your patio. For more details on setting up receiver-based multi-room system, see our article on Powering a Multi-room Music System.
If, on the other hand, you're interested in accessing digital music sources – including your own music collection, Internet radio stations, as well as services like Pandora and Spotify – a wireless multi-room system may be a better fit. For more info, see our article about wireless multi-room options.
Usability: on-screen displays and remote controls
In almost every respect, today's sophisticated audio video receivers are more fun and more capable than those of previous generations. They offer more refined video processing, more detailed surround sound, and a ton of entertainment options. Perhaps the biggest challenge that receiver designers face is how to conceal all that complexity and make their products easy to operate.
A clear, intuitive GUI (the graphical user interface that displays on your TV screen) can make initial setup quicker and easier, and can also improve certain aspects of day-to-day use. To get a sense of what makes a good GUI, we set up a few home theater receivers in the Crutchfield Labs and gave them a try.
This "NET TOP" screen provides a menu of networked entertainment options.
GUI features we liked
Explanatory text
"PL IIX Music Panorama," "TrueHD Loudness Management," "i/p scaler" – the titles for receiver settings are not always immediately clear or intuitive, and their meanings can change depending on where you are in the menu system. That's why having simple, plain-English definitions of what each setting does can make a huge difference when it comes to usability. Instead of taking the time to search through the receiver's owner's manual, or just making a choice and crossing our fingers, we can make an informed decision on the spot.
Effectively using connected sources to test your setup
During the setup process, even experienced A/V geeks may accidentally connect cables to the wrong input, or even forget a cable altogether. And although double-checking cable connections is generally the first trouble-shooting step, it can sometimes take a little time to figure out exactly where something went wrong.
That's why we love interactive GUIs that use our sources to check connections during the setup process. For example, as the last step in testing our Internet connection, the Denon 3313 asked us whether we could hear the Internet radio station it was playing. Similarly, Onkyo's 717 walked through each of our connected A/V components, playing the picture and sound from each and asking if both were working correctly.
Remote apps for smartphones and tablets
Some receiver manufacturers offer Apple and Android apps that allow you to use your smartphone or tablet as a remote control (with compatible models). Although we tend to use the receiver's remote for things like initial setup and source selection, the remote apps are generally much better at things like navigating digital music sources and controlling multi-zone playback.
Yamaha's remote app for iPad offers easy touchscreen control for multi-zone playback, as well as volume control, source selection, browsing free Internet radio streams, and other functions.
So, for example, we'd opt to use a standard remote if we were settling in to watch a Blu-ray movie. Finding the volume button in the dark is easier with a hard-button remote, and quicker than navigating into a smartphone or tablet app.
If, on the other hand, we wanted to listen to Pandora or Spotify, the app offered much quicker, more intuitive navigation. Instead of using the hard-button remote to laboriously scroll through lists of artists, genres, etc., we could use the app to simply tap the content we wanted to listen to. The apps also made multi-zone playback a snap – being able to see and select each zone and source was more straightforward than pressing a combination of buttons on the included remote.
Marantz's remote app lets you make selections from online music services like Spotify.
Next steps
Ready to start shopping?
Check out our selection of home theater receivers. Or go old school with a stereo receiver.
Still want to do more research?
Here are some other articles you might find useful:
- Learn more about surround sound and home theater with our articles about speaker placement for home theater, surround sound formats, and home theater speakers.
- Get tips on setting up your new receiver for the best picture and sound.
- Find out more about building a receiver-based multi-room system, or creating a wireless multi-room setup.
Don from Medford ORPosted on 6/3/2015 12:37:47 PM
Router. My computer and router are located in another part of the house and to far for a LAN connection on a receiver. Are there any other ways to make this connection. Thanks. Don
Alan Meier from Stockton, Ca.Posted on 6/21/2015 4:58:38 PM
Help. How many channel receiver do I need? This is what we have. Family room with four ceiling speakers, sub woofer, a center channel. We have a pair of in wall speakers in formal living room and a pair on out door speaker on patio. Both patio and living room speakers have separate controls to turn volume off and on. In family room we plan on buying a Samsung SUHD 65" 4k JS9000 or JS8500 TV and a pair of front and rear speakers. I like the Atmos system. What speakers and receiver would you recommend? Budget of 3k for speakers an receiver.
Rick Johnson from La VetaPosted on 8/2/2015 3:08:24 PM
I was thinking on getting a onkyo receiver and wanted to know if i got the 737 model how hard it would to be to st up dolby atmos our internet is not the best here. I would like to get the new surround option but if not i don't mind using the regular dolby true hd and dts hd options.
Tom from BrentwoodPosted on 8/2/2015 6:39:08 PM
What a great article. Thanks for taking the time on writing this. As you know, the technology is changing so fast, our AV guy just can't keep up with it. I have an Onkyo NR808. and it's just not performing. I purchased it for the pwr, and the 7.1 Onkyo replaced the pwr amp under extended warranty. I had to purchase a new BluRay, as the new movies no longer played. Thanks Samsung. (No SW upgrades.) For a high power Receiver with 7.1, what would you recommend? I am using all Definitive speakers. We have a 65 Samsung non 3D. Most likely we move to a 4K.
Nick from ChicagoPosted on 8/24/2015 1:46:34 PM
Thanks for the great article. I still have this one question; in your experience and with the products currently available, what receiver/brand would you recommend that does the best at 5.1 channel surround theater as well as pure, clean 2-channel stereo for music lovers? I'll looking for a one piece solution but don't want to skimp on the sound quality too much in either arena, without going to a separates solution.. I dont need anything more than 5.1 but I'm seeing less and less options for it out there. Am I better off with the newer 7.1 components?.. I still want great, clean 2 channel Stereo. Thanks for your help!
Jason Wentsel from LivermorePosted on 12/2/2015 10:21:59 PM
G'day! Very informative article, thank you! I was hoping you could helpcme out. I recently received aa Denon S710WW A/V Receiver for my bday. I was excited till I found out I need to buy speakers, lol! Thanks step-mum. I'm having a hard time understanding how to pair the appropriate 5.1 speakers to this receiver. Could you give me a few ideas and why they would work? Jason W
Don T.Posted on 5/21/2016 2:11:28 PM
Very informative. Thanks to Crutchfield for putting all of this information in one place and making it easy to understand.


text:
Serves 5 |
Prep Time 15 minutes |
Cook Time 1 hour 20 minutes
1 cup Eden Dry Black Beans, soaked
5 cup water
1 cup diced onions
1/4 cup diced celery
1/4 cup diced red bell pepper
1/2 cup organic sweet corn, fresh or frozen
1/2 tsp Eden Sea Salt
2 Tbsp finely chopped scallions
1/4 tsp cumin
1/2 tsp lemon zest
Place soaked beans and water in a medium soup pot and bring to a boil. Reduce the flame to medium-low, cover and simmer 1 hour or until about 80% done. Add onion, celery, peppers, sweet corn, sea salt, cumin and lemon zest. Cover and simmer another 20 minutes or until the beans are tender. Serve garnished with scallions.
American, Beans, Condiments, Gluten-Free, Good/High Fiber, Good/High Protein, Low Calorie, Low Fat, Macrobiotic, Mexican/Spanish, No Sweetener Added, Soup, Chili & Stews, Vegan, Wheat-Free


text:
Struggles of Boston Amputees Mount
As Limelight Fades, Some Victims Feel Pressure to Be Resilient for Boston
LOWELL, Mass—Settling carefully into a chair at a brew pub, Celeste Corcoran surveyed the other diners. Most of them wore shorts, and she gazed at what seemed like a sea of tanned legs.
"They don't even realize what they have," she said.
Mrs. Corcoran, a 47-year-old hairdresser from this working-class city northwest of Boston, lost both legs when twin bombs ripped through the Boston Marathon finish line. Five months later, even routine outings can leave her feeling wistful.
State-of-the-art prostheses are slowly helping Mrs. Corcoran reclaim independence, but she can tolerate them only for a few hours a day. Her husband carries her upstairs to bed each night, and she sometimes feels stabbing pain in toes she lost months ago. Like many of the 16 people who lost limbs in the bombings, she has found recovery can be a grueling ordeal of setbacks and frustrations.
"When I got these legs, I was almost expecting a miracle," Mrs. Corcoran said. "But it's still so hard, so hard."
Many of the bombing victims, including Mrs. Corcoran, feel fortunate to have survived. More than $60 million paid out from a compensation fund is easing financial anxieties. The amputees also benefit from medical advances growing out of the wars in Iraq and Afghanistan, such as prosthetic legs with knees controlled by computer chips.
But as Boston moves on from the April 15 attack, which killed three people and wounded more than 260, some amputees find themselves on a lonely road, grappling not only with pain and repeated surgeries but with an emotional fallout that includes pressure to be billboards for Boston's resilience.
"The citywide collective has almost required them to be ambassadors for that mentality 'Boston Strong,' but not every day is good," said David Crandell, amputee-program director at Spaulding Rehabilitation Hospital, which treated 15 amputees. The city adopted the resolute slogan after the bombings.
Counselors say some amputees are starting to withdraw from all the appreciative attention they got—throwing out first pitches at Fenway Park and being honored at a Patriots football game—amid the realization their recoveries aren't straightforward tales of resolve and success.
Deborah Allen, director of child, adolescent and family health for the city of Boston, which runs a survivor support group, said the limelight offers comfort and resources, but it "comes at a price of slowing down the process of getting to your real life and what you have to deal with day to day."
A decade ago, the popular perception of amputation was unnecessarily dark, said Douglas G. Smith, a professor of orthopedic surgery at the University of Washington and a former medical director of the Amputee Coalition, a national nonprofit organization. Today, after young and strong veterans have returned from war with prostheses, he said the view of amputation may be too rosy.
Dr. Smith estimates it takes 12 to 18 months before a traumatic amputee is fully recovered and an unpredictable time to adjust to artificial limbs. "The range of outcomes is bigger than people want to imagine," he said.
There have been some victories. One Boston amputee recently went stand-up paddle-boarding. Doctors describe the group as relatively young and determined, boding well for their recovery.
Still, upbeat stories can belie hidden struggles, said Roseann Sdoia, who lost her right leg above the knee. "People want to see how quickly everyone is recovering, but it's sort of misleading," said the 45-year-old Boston resident. She recently delayed plans to return to her property-management job because of pain and uneasiness walking on her own. "I feel like I've plateaued in my recovery, and it's frustrating."
Their challenges stem from complex injuries. Amputations in the U.S. typically are planned procedures. But in Boston, the explosions of pressure-cooker bombs packed with nails and BBs shredded muscles, tendons and nerves. They embedded tissue with shrapnel, raising the risk of infection.
"It sounds grotesque, but if you could imagine, it's like putting your leg into a garbage disposal," said William Creevy, an orthopedic surgeon at Boston Medical Center, which treated five amputees.
Doctors fought to save as much limb as possible, but in half of the 18 amputations, on 16 people, patients lost the use of their knees. That means greater exertion while walking, more difficulty doing everyday tasks and more wear on other joints.
Some amputees have yet to resume walking. Erika Brannock, an upbeat 29-year-old preschool teacher from Maryland, lost her left leg at thigh level and had serious wounds to her right leg. Two failed tissue grafts have kept her in a wheelchair, although she said she is aiming to start using a prosthetic leg soon following her latest graft.
Above-knee amputee Marc Fucarile, a 35-year-old former delivery-truck driver from Stoneham, Mass., finds that his remaining, badly burned left leg sometimes hurts so much he thinks life would be easier if he had lost it, too, said his fiancée, who spoke on his behalf.
Mr. Fucarile was with friends, including brothers J.P. and Paul Norden, when the second bomb went off. The brothers became amputees, too.
Paul Norden, 32, lost his right leg above the knee. He is walking with a sophisticated prosthesis. But he fell recently when he hopped out of bed, forgetting he didn't have a leg.
A private person, the heavily tattooed former roofer said he is weary of being recognized in public as a bombing survivor.
J.P. Norden, 33, had been making progress, even driving by using his left leg to press the pedals. But to his frustration, by September he was headed back to surgery, marking the latest setback slowing his adjustment to life as an amputee.
Going upstairs at his mother's home outside Boston requires slow rides on chair lifts. When he walks, crutches keep him from carrying anything. At night, he can't get to the bathroom because the prosthesis is too difficult to use. Mr. Norden thinks it will be a year before he can resume his work in construction.
'On her down days, Celeste Corcoran simply tells her family, I'm sad today because I don't have my legs.'
Sitting in an exam room at Brigham and Women's Hospital just before Labor Day, he poked at a grapefruit-size mass on his left thigh. The muscle on this "good" leg, the one not blown off, felt as hard as concrete.
One of the marathon blasts slammed debris, including the car keys in his pocket, deep into his thigh. Medical workers pulled the keys out, but as the gash healed, muscle turned into bone in a bizarre condition called "heterotopic ossification," most often seen in soldiers. Doctors plan to carve out the mass in one of multiple surgeries still looming.
"It's just like, 'Oh man, I've gotta deal with this again?' When is it gonna end?" Mr. Norden said.
He spoke at the hospital just before an operation to sew some skin and a blood vessel from his back onto the bottom of his amputated leg, to create a cushion so he could bear weight on a prosthesis.
Plastic surgeon E.J. Caterson told him that the surgery, which ended up lasting almost 10 hours, would include excising a second abnormal bone growth, on Mr. Norden's other leg.
His mother, Liz Norden, wiped away tears. "He's getting better, Mom," Dr. Caterson reassured her. "He's getting better."
Even amputees who are walking again face challenges. Arthur Graham, the clinical manager at Next Step Bionics & Prosthetics, a Newton, Mass., firm that is treating seven of the amputees, said he has spent a lot of time managing their expectations.
After the bombings, he heard public predictions they would be running next year's marathon. But the first year, in particular, can bring a host of challenges, Mr. Graham said. Severed limbs frequently swell and then shrink as muscle atrophies. Rashes, chafing and pain can arise.
"There was a lot of setting the bar very, very high, unrealistically at first," Mr. Graham said.
Amputees are contemplating more-accessible homes and pricey prostheses. They have raised money themselves and have benefited from the One Fund, established by Boston's mayor and the Massachusetts governor with private donations, which paid them $1.2 million or $2.2 million each, depending on whether they lost one leg or two.
Dr. Crandell of Spaulding Rehabilitation Hospital said insurers have largely covered the best prostheses, the fanciest of which can cost more than $100,000, though that isn't typical. He worries that survivors may face steep bills when they start having to replace the artificial limbs every three to five years.
Not long after the bombing, Mrs. Corcoran—a warm and talkative woman with an armful of jangly bracelets—was at home surrounded by flowers and cards from well-wishers world-wide.
She had lost legs, one at knee level and one below the knee. Her teenage daughter Sydney had severe shrapnel wounds. Along with Mrs. Corcoran's husband, they were rooting for Mrs. Corcoran's sister, a runner.
"It could have been worse, you know. You always have to come back to that. You really do," Mrs. Corcoran said in May. She joked that she wouldn't have to worry about shin splints when she went running on her artificial legs. At the first fitting for her prostheses, she requested two extra inches to boost her former 5-foot-4 height.
A little more than a month later, reality looked far more daunting. Her severed limbs felt bruised and swollen, the prosthetic legs clunky and hot. Used to being the caretaker in her family, she bristled at her new dependence. She cried when it took two physical therapists to help her shuffle down a hospital hallway.
Difficult emotions surfaced. She acknowledged almost envying the single amputees at the rehab hospital.
And while a month earlier she had pledged she wouldn't waste a minute thinking about alleged bomber Dzhokhar Tsarnaev, she fumed that she might like to "punch him in the face."
The 20-year-old Mr. Tsarnaev has pleaded not guilty to charges related to the bombings, which authorities believe he carried out with his brother Tamerlan, who died days later after a shootout with police.
Sophisticated prostheses lifted Mrs. Corcoran's hopes over the summer, and with practice, the professional hairdresser stood and trimmed some hair. She felt her freedom inching back and appreciated new doors opening, such as when a local company offered her daughter a college scholarship.
But by mid-August, chafing on the bottom of what remained of her legs temporarily forced her back into a wheelchair. Now, as she settles into a routine at home, daily life feels foreign.
Most of the time, Mrs. Corcoran manages to stay positive, but "there are days when I'm crying, I'm having a tough time, and I'm in pain," she said. On her down days, she has begun simply announcing to her family and friends, "I'm sad today because I don't have my legs."
"It's one thing to feel strong, and you need to feel strong, but not to the point where you can't show your emotions because you're 'Boston Strong' and nothing gets us down," she said.
During the recent restaurant trip, Mrs. Corcoran gripped daughter Sydney's arm and walked haltingly from the car. Her expression dropped when she saw counter-height pub tables, and she waited in the lobby as the manager scurried to find a lower, more-accessible table.
"I knew this was not going to be easy," she said of her new life. "But I didn't realize how hard it was going to be."
Write to Jennifer Levitz at email@example.com and Jon Kamp at firstname.lastname@example.com


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on May 8, 2013 - 11:29 PM
Nov. 16, 1925 – May 7, 2013
Albert J. Bassanello, who owned and operated Al's Barber Shop in Akron for more than 60 years, died Tuesday in Buffalo Veterans Affairs Medical Center after a long illness. He was 87.
Born in Oakfield, he attended Akron High School and served in the Navy during World War II aboard the USS Ticonderoga in the South Pacific.
Mr. Bassanello became interested in barbering while in the Navy. He attended barber school in Buffalo, then returned to Akron and opened a shop on Main Street in the heart of the village. He continued cutting hair until he was 80.
He was a longtime member of the Akron Fire Company; Newstead Memorial Post 3180, Veterans of Foreign Wars; and L.L. Tillman Post 900, American Legion, where he served as historian.
He also was a member of St. Teresa of Avila Catholic Church.
Survivors include his wife of 65 years, the former Eva Chiavacci; a daughter, Susan Houlihan; two sons, Thomas and David; a brother Adolph; and a sister, Anita Calnan.
A Mass of Christian Burial will be offered at 10:30 a.m. Saturday in St. Teresa of Avila Church, 5771 Buell St., Akron.


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TRUCKEE, Calif. - The Canyon Springs project that proposes to develop a portion of the eastern Truckee landscape has the potential to generate significant environmental impacts in a number of areas, consultants and planners have concluded.That potential is one of the major findings included in the draft Environmental Impact Report on the proposed residential neighborhood near Glenshire, which consists of 185 lots on approximately 108 acres, out of a total project area of 284 acres. Planning Center | DC&E, a recently merged planning and consulting company, spent the past year and a half preparing the document that was released Dec. 19.Considering the timing before the holidays, the developer and organizations interested in the project were hesitant this week to offer much analysis on the report's findings."We have not reviewed the 600+-page document thoroughly enough to make any comment on its findings yet," said Leigh Golden, president of SOS Glenshire, one of the more outspoken organizations that's in favor of protecting the property.Other organizations, including the Mountain Area Preservation Foundation and Glenshire/Devonshire Residents Association, shared a similar view, as did Christopher "Chip" Huck, one of property owners and project manager for Canyon Springs. "It is premature to provide substantial thoughts at this time as our review will be thorough," Huck said. "... Overall, the project is consistent with zoning and general plan policies, and to that extent it appears the draft EIR has evaluated the project within those parameters."
Some areas analyzed in the draft EIR include land use planning, population and housing, public services and recreation, aesthetics, air quality, greenhouse gas emissions, water quality, noise, traffic, biological resources, and hazards and hazardous materials. A few environmental areas that could be "significantly" impacted by the project, according to the draft EIR, are:• Biological resources, in terms of removal of Jeffrey pine and snags or sagebrush habitats that could impact certain wildlife species, as well as the installation of wood piles for pedestrian footbridges possibly impacting site wetlands and non-wetland waters.• Hazards and hazardous materials, in terms of introducing homes in an area of "dense vegetation and forested land" that could expose people or structures to a "significant risk" of "loss, injury or death" from wildfires.• Hydrology and water quality, in terms of ground disturbance due to construction that may cause erosion to exposed surfaces during rain and snowmelt; creation of roads and houses and "slight changes" in local topography could possibly alter surface runoff rates and drainage patterns; and "urban runoff" from roads and driveways possibly exposing metals and "petroleum-based contaminants" to waterways.The draft EIR identifies several in-depth measures that, if taken, would reduce significant impacts to "less than significant."For example, one measure includes the submission and approval by the Truckee Fire Protection District of a fire safety and fuel modification plan before building permits are issued. In terms of fire safety, there should be "adequate safety" for emergency fire equipment and people, "a point of attack or defense" from wildfires and strategic placing of defensible space.In terms of fuel modification, the draft EIR suggests the removal of underbrush and dead or dying tree branches a minimum of a 100 feet from the perimeter of structures, that "flammable vegetation" within 10 feet from roads and driveways should be removed, and that flammable vegetation within 30 feet of all structures should be removed.Areas analyzed and determined by the EIR to require no mitigation measures due their "less than significant" nature include: noise, agriculture and forestry, population and housing, greenhouse gas emissions, public services and recreation, utilities and service systems, aesthetics, and land use and planning."We plan on thoroughly reviewing the project internally and with hired experts, as there has been past controversies with this proposed development in the community," said executive director Alexis Ollar and board president Nikki Riley of MAPF, in a joint statement.SOS Glenshire will also hire experts to review the report, Golden said, while the Glenshire/Devonshire Residents Association may do the same, said Sally Lyon, chair of the association.
The public will have until March 1 to comment on the draft EIR - 28 days more than the California Environmental Quality Act (CEQA) required comment period of 45 days."Part of the reason for that is we recognize it's the holidays, it's a busy time of year and it's also a very lengthy document, and we want to make sure everyone has adequate time to review that," said Terri McCracken, an associate with The Planning Center I DC&E, at a Dec. 18 public meeting about the project in Truckee Town Hall.To help with in review process, a public meeting will be held on Jan. 29, and McCracken, along with technical staff, will be present to answer questions about the draft EIR and its findings."It's important that when you do submit your comment that you do state a very specific concern," McCracken said. "General things like 'I don't understand air quality,' there's very little I could do with that. But if you do have a specific concern about a mitigation, if you identify a page number, anything that makes a direct nexus to your concern and the environmental impact is really going to be helpful."After March 1, the company will begin work on the final EIR, a document that responds to comments received on the environmental analysis and possibly includes revisions to the draft EIR if an environmental impact was missed or done incorrectly.The timeline for the completion of the final EIR is unknown at this time, said Denyelle Nishimori, senior planner for the town of Truckee."It really depends on the amount and length of comments that the town receives on the draft, because we have to go through each and every comment very carefully and respond to them within that final document that we prepare," she said. "So there's not a definitive date that we can give you at this time." Once the final EIR is completed, it will go before the town council and town's planning commission for potential adoption and certification. McCracken said that is anticipated to take place early this spring. "It's important to recognize that the certification of the EIR is not the same thing as project approval," she added.


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Full CoverageBreaking News
Jerusalem residents reflect on Sharon
Former Israeli prime minister died SaturdayPublished 3:06 PM EST Jan 11, 2014
Former Israeli Prime Minister Ariel Sharon is considered a hero by some and a war criminal by others. On the day he died, Jerusalem residents from across the political spectrum reflect on Sharon's life and death.
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UNIVERSITY PARK - Before Penn State's final home dual meet of the season, against Rider, a Division I school in Lawrenceville, N.J., the Nittany Lion seniors were recognized and celebrated before 6,532 Sunday at Rec Hall.
And then the Lions, ranked third in the USA Today/NWCA/AWN Coaches Poll, went out and pounded the Broncs.
The Lions recorded five pins, including a first-period pin by senior Bryan Pearsall, and three major decisions, including a 12-4 win by senior Quentin Wright, and routed the Broncs, 48-0, for their fourth shutout of the seaon.
In addition to Pearsall and Wright, James English, Andrew Church, Nick Fischer, Derek Reber and manager Taylor Durci were recognized before the meet. English as just awarded a sixth-year of eligibilty, but he hasn't decided if he'll return.
"They're the ones that bought into the system, and that's obviously huge. You've got to have guys on board," Penn State coach Cael Sanderson said. "Senior night is always tough. I'm never going to see Quentin Wright wrestle in Rec Hall again. That's a bummer. I'm never going to see Pearsall [wrestle in Rec Hall].
But, it's a celebration of their career. We're very happy for them, and where they're at. There's still a lot of wrestling to do, but they won't be in Rec Hall anymore."
"I've been blessed with great teammates and great coaching staff," Wright said. "Everything has just been a dream these past four or five years. There's been a lot of ups and downs and all-arounds. It was a lot of fun. It's probably going to hit me next home next year. You're now allowed to go back and weigh in. I didn't think I'd ever say that. It will hit us later on because we're still in national title mode."
Joining Pearsall in the pin parade were Nico Megaludis with a fall in 3:48 at 125, David Taylor in 3:48 at 165, Matt Brown in 4:06 at 174 and Ed Ruth in 2:38 at 184.
"I was just looking for an opening," Pearsall said. "Obviously, I wanted to get the fall. It would have been nice to get a little mat time out there, but I saw an opening, and I had to take it."
"I like to see our guys looking for pins, especially at this time of the year," Sanderson said, "because that's what is going to win the national championship. It's going to be pretty even if everybody just wins. I think that's what separated us from the rest of the pack the last two years."
Penn State (12-1), as always, had a big advantage in the takedowns category. The Lions held a 30-1 advantage, and the one the Broncs (10-7) got was against the second-ranked Taylor. Ramon Santiago, ranked 20th, took him down right off the whistle, but in the second period, Taylor stuck him quickly with a bar-arm and half nelson.
Dylan Alton had one of the toughest bouts of the afternoon, earning a 5-2 at 157 win fifth-year senior Zac Cibula, who is unranked but won four Wisconsin state titles. Alton had two takedowns in the first two periods, but he was pushed by the physical Cibula.
"He had a tough, physical kid," Sanderson said, "and the kid did a real nice job of getting his hands on Dylan and trying to control the tieup. Dylan did what he needed to do. He hit some nice shots. Rider has some good kids in there. The score didn't look very good, but it's a good match for us this time of the year. Dylan definitely wrestled one of their better kids."
Dylan's brother, Andrew, hit a four-pointer right away against Curt Delia and earned a 12-4 major decision at 149. Jordan Conaway (133) also had a major decision.
The other decision came at 285, where Jimmy Lawson earned a 3-0 win over Greg Velasco to close out the meet. Lawson appears to have taken over the 285-pound spot from Jon Gingrich, who won some big bouts earlier in the season.
"It's not finalized," Sanderson said, "but we're working on it. We've been giving Lawson the nod the last few matches, and I guess that's a pretty good indicator of what we're doing."
Notes: Penn State will close out the dual meet season next Sunday at Rutgers. ... The Lions had wrestled Rider twice before, beating the Broncs 41-0 in the 2007 Virginia Duals and 38-3 in the 2003 Virginia Duals. ... After the press conference, the Lions were whisked off to an autograph session with very long lines.
125-Megaludis, PS, pinned Skinner, 3:48; 133-Conaway, PS, pinned Schupin, 19-5; 141-Pearsall, PS, pinned Cignay, 2:01; 149-A. Alton, PS, maj. dec. Delia, 12-4; 157-D. Alton, PS, dec. Cibula, 5-2.
165-Taylor, PS, pinned Santiago, 3:48; 174-Brown, PS, pinned Brundage, 4:06; 184-Ruth, PS, pinned Wolfe, 2:38; 197-Wright, PS, maj. dec. McNeil, 12-4; 285-Lawson, PS, dec. Velasco, 3-0.
Records: Rider (10-7), Penn State (12-1).
Att: 6,532.


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Semitron® MPR1000 is a new engineering material developed for Semiconductor applications and more specifically for use in vacuum chamber applications such as these found in Etch, CVD and Ion Implant.
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Expanding Use of NGS Has Largely...
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Errors in cell-signaling pathways play a central role in many diseases including cancer, diabetes, and autoimmune disorders. The ability to study these signaling pathways and accurately measure protein and protein phosphorylation levels is increasingly important in drug discovery and the development of disease models.
Traditional multiplexed immunoassays such as those conducted on the Luminex® xMAP® platform have advanced our understanding of intracellular communication by enabling the ability to measure multiple total or phosphorylated sites along a signaling pathway in a single sample, and simultaneously measure sites in multiple pathways. However, multiplexing still presents some challenges as there is a lack of phosphospecific antibodies that work well on the Luminex xMAP platform due to:
Resulting difficulties include a lack of sufficient targets for pathway analysis, qualitative or relative quantitative results, and the need for separate wells to analyze each phosphorylated site on a specific analyte as well as total protein.
To overcome these challenges, the MILLIPLEX® MAP EpiQuant™ receptor signaling portfolio (EMD Millipore) enables researchers to measure phosphorylation levels of multiple sites, as well as total protein, simultaneously with absolute quantitation.
Based on the Luminex xMAP platform, the technology uses antibodies against defined protein sequences to capture peptides resulting from protein linearization and digestion in a single cell lysate sample. The fragments generated are similar to those generated using mass spectroscopy. These same peptides are then used as standards to generate curves with picomolar sensitivity.
This multiplexing technology provides faster answers to cell signaling questions compared to traditional Western blots, mass spectrometry analyses, and radioactive phosphorylation assays requiring large amounts of resources, time, and sample.
The ErbB or epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases consists of four members: EGFR/ErbB1/HER1, ErbB2/Neu/HER2, ErbB3/ HER3, and ErbB4/HER4. The ErbB receptors play crucial roles in propagating signals regulating cell proliferation, differentiation, motility, and apoptosis, contributing to pathological processes such as cancer. The ability to analyze the phosphorylation status of ErbB family members, as well as the phosphorylation status of receptor-related intracellular signal transduction proteins, is necessary for a thorough understanding of this signaling pathway.
The MILLIPLEX MAP EpiQuant EGFR pathway panel profiles 29 ErbB signaling pathway constituents. The assay enables the analysis and quantitation of tyrosine phosphorylation sites on ErbB2 and ErbB3, and multiple sites on ErbB1, as well as tyrosine phosphorylation sites for 16 other receptor-related proteins, including ERK1/2 and multiple Gab2 and FAK sites. In addition to containing 20 phosphorylated targets, the assay is also able to quantify total EGFR and a loading control (TAFII68) simultaneously in a single assay well.
Figure 1 shows results of an analysis of A431 human epithelial carcinoma cells treated with EGF, H2O2, or vehicle. Following lysis and digestion, EpiQuant™ beads (a 22-plex) were added to samples containing the target proteins shown. Samples were analyzed on a Luminex 200™ reader. Data shown are the mean pM values from four observations. Increased phosphorylation was noted for EGFR, Her2, IL-15R, Shc, and Tec compared to vehicle-treated cells.
The EGFR pathway panel enables the detection of phosphorylation events for all panel analytes in dose response and time course experiments. Figure 2 illustrates the results of a dose response experiment for several targets. Of interest is the observation that concentration of EGF needed for maximal activation of the two EGFR phosphorylation sites appears dissimilar.
Signaling events initiated by extracellular receptor activation lead to the expression and release of cytokines/chemokines. These events are central to cellular and tissue homeostasis, and developmental and functional response. The complexity and number of signaling proteins involved in cellular responses require multiplex analysis of samples.
A549 lung carcinoma cells were cultured, and then stimulated with either EGF or TNFα. For the cytokine/chemokine analysis, tissue culture media were collected at various time points over a 24-hour period, as well as unstimulated controls. In addition, cell lysates were collected at time points over a one-hour period. Prepared samples were assayed according to the MILLIPLEX MAP Human Cytokine/Chemokine-42-plex protocol and the MILLIPLEX MAP EpiQuant Phosphotyrosine Cell Signaling Panel 1 protocol, respectively. A total of 42 soluble analytes and 105 intracellular phosphotyrosine proteins were analyzed (Figure 3).
Analysis of TNFα-stimulated A549 supernatant revealed an increased expression in 21 of the 42 screened cytokine/chemokine analytes. Of the 105 phosphotyrosine cell signaling targets analyzed, a response was observed in 38 target sites for TNFα− or EGF-treated cells. The magnitude of cytokine/chemokine and phosphotyrosine response varied significantly between targets. For several phosphorylation sites, a decrease in phosphorylation was observed in response to TNFα treatment.
The complexity and number of protein targets involved in signaling events, as well as cellular responses, require tools that enable multiplex analysis of samples. MILLIPLEX MAP EpiQuant technology enables the analysis of a greater number of intracellular analytes per well compared to even traditional Luminex intracellular assays. The magnetic bead format of these assays provides additional convenience with walk-away washing options and increased consistency, resulting in lower coefficients of variation.
Rick Wiese, Ph.D. ([email protected]), is R&D manager at EMD Millipore.
Rick Wiese, Ph.D. ([email protected]), is R&D manager at EMD Millipore.
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While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
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Sitting in a white fluffy bathrobe in front of her bathroom mirror, Robin Roberts – still recuperating from a bone marrow transplant just five months earlier – seems at ease with her striking reflection. Just as she was after battling breast cancer in 2007, Roberts is once again bald, but this time she's skipping the wig.
"Whatever," the Good Morning America anchor says with a shrug. "I'm thankful I have a pretty-good-shaped head." And the 30 lbs. she's lost from her 5'10" frame during her month-long hospital stay? "It's been hard to put back on, a first in my life," she admits. "But I gained a pound last week in New Orleans. Woo-hoo!"
And when Charlie Gibson, an old friend and former GMA cohort, drops by her Manhattan apartment and asks how she is, she replies as if nothing eventful has happened: "I'm good. How are you?" she says casually. "No, I wasn't being polite," Gibson replies. "I really want to know, 'How are you?' "
That's the question millions have been asking ever since the anchor left GMA last August to undergo a bone marrow transplant for a rare blood-and-bone-marrow disease called myelodysplastic syndrome, which can lead to a fast-growing form of leukemia.
"Every day I feel more like my old self. I didn't think I would," Roberts says, noting that she was so weak when she left the hospital in October, she could barely walk. While some shaky moments persist – "I've still got chemo brain and my vision is blurry" – Roberts is eager to return to her GMA anchor chair at last on Feb. 20, exactly five months after her transplant. "You feel so bad for so long, you just want to feel normal. And now I do."
She also has a new sense of perspective after fighting for her life for a second time. While Roberts, 52, projected an upbeat, brave persona in blog posts and tweets during her recovery, "it's important people know I'm not always like that," she says. "But I choose to be happy and not string together the bad days." Says her sister and bone marrow donor Sally-Ann: "We've been through a lot the last few months," including the death of their beloved mom, Lucimarian. "I marvel at Robin's strength."
Just as she was about to begin treatment, another life-altering event intervened: Roberts had to race home to Pass Christian, Miss., during Hurricane Isaac to say goodbye to her ailing mother, who died just hours after Roberts reached her on Aug. 30.
The trip came at a pivotal moment for the terrified Roberts. "I don't care how old you are; when you're sick, you want your mom," she says, choking up. "And I wanted my mom."


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Will Reinke scored 27 points, gathered 16 boards, six blocks and five assists in an 87-63 Oklahoma Christian victory over Mid-America Christian.
Oh, and he also had the sports highlight of the night, and maybe not just in Edmond. Or in Oklahoma.
In this video clip (courtesy of Eagle Media), Reinke grabs a board and takes the basketball the length of the Dan Hays Court, slamming it home to the thunderous delight of Eagles' fans in the Eagle's Nest.
Oklahoma Christian student broadcaster Shane Magness has the call. If you have a sports highlight the world needs to see, email us at firstname.lastname@example.com.


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