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on January 23, 2013 - 3:44 PM
Andrew T. Spears, who was convicted of first-degree robbery in a Black Rock home invasion case, was sentenced Wednesday to 12 years in prison.
State Supreme Court Justice Christopher J. Burns cited the 25-year-old Town of Tonawanda man's criminal past when sentencing him.
"The history of Mr. Spears cannot be ignored," Burns said.
Spears was convicted of attempted arson in 2007, for which he served state prison time.
In October 2011, the Black Rock victims, a man and a woman, told police that two intruders entered their apartment in the 1900 block of Niagara Street shortly before 2 a.m. and demanded money at gunpoint.
Spears and his brother, Lonnie, 29, of the City of Tonawanda, stood trial. A jury acquitted Andrew of several charges but convicted him of first-degree robbery.
The two victims said the robbers took three cellphones and $700 in cash from the man and one of them hit him in the face with the handgun.
The other intruder fired several shots over the man's head, according to a police report.
Spears asked Burns to set aside the verdict because of insufficient evidence. Burns denied the request.
"I'm a stand-up citizen. I'm ready to be sentenced," Spears said when asked if wanted to make a statement before sentencing.
Burns said his criminal record shows Spears is not a model citizen.
"This was a violent episode," Burns said. "There was no reason for it."
Lonnie Spears, convicted of second-degree criminal possession of a weapon, was previously sentenced to 12 years in prison as a second-time violent felony offender.
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Going to sleep with your laptop open next to your pillow and running Skype and watching your girlfriend or boyfriend, who is doing the same. Wake up still sleeping together on Skype.
We started to Skype sleep when we separated for college.
автор: So close 8 октября 2010
Trending Now
Can you define these popular missing words?

subset: commoncrawl


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I am trying to find someone from India preferably from Bombay with whom I can share my views. The stats which Vandaar has given shows as I am the only one who has visited this site.
If anyone of you happen to know someone in India (Bombay) with NF1 please let me know also if anyone of you happen to visit India (Bombay) we should make it a point to meet.


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CHARLES TOWN - Since December 1892, Tchaikovsky's "The Nutcracker" has been performed by thousands of dance companies all over the world. This year, the Old Opera House Dance Studio is performing its interpretation of the famous classical ballet.
One may ask how the same production that's been done a thousand times can be performed in a fresh and new light. Amanda Cipriano, choreographer and artistic director of the OOHDS says it's easy - she gets her inspiration from her students.
Unlike some studios, the OOHDS performs their Nutcracker every other year versus annually, so with that not only does the enrollment change, but so do the abilities of each dancer.
Article Photos
"I focus on the individual and their strengths," Cipriano said. "My inspiration is the dancer."
Many of the same dancers have the same role they performed two years ago, but they see that as having the ability to perfect their dance.
Kendall Turney, who plays the part of Clara; Tess Hyre, who dances as the Sugar Plum Fairy; and Dezwell Carr, the Nutcracker Prince, all danced these same roles two years ago, and they all agree their performances have improved tremendously.
Fact Box
What: The Nutcracker
When: 7:30 p.m. Friday and Saturday, 2:30 p.m. Sunday
Where: The Old Opera House
Cost: $12 Adults, $8 Students and Children
For more information or to purchase tickets, contact the Old Opera House box office at 304-725-4420.
"Last (performance), I had never done the role before and it contains a lot of acting," Turney said. "I think this time around I took more time to think about the role and not just the technique. Clara has to have different facial expressions. She has to be scared, excited, annoyed - lots of different things."
"A lot of us are getting the opportunity to have the same roles, but we're getting better and more professional," Hyre said "We're able to perfect things because we've been working on them longer."
This is Carr's third performance as the Nutcracker prince and said he's come a long way in the past four years.
"(The choreography has) changed a lot for me," he said. "When I first started here I had no dance experience at all. Now I've progressed to moves I couldn't do four years ago."
Now Carr partners with different dancers of various shapes and sizes, adding to the difficulty of his role.
"I love it," he said. "There's still a lot for me to learn."
"I believe both (Turney and Hyre) have encompassed their role again," Cipriano said. "I believe they have perfected their role, yet given it a whole new look. Each role is technically harder."
On the flip side of OOHDS' Nutcracker coin are those dancers that are performing in new and more challenging roles for the very first time.
Isabella Sager, 12; Mallory Snyder, 14; Sarah Leonguerrero, 14; and Sydney Morre, 10, are all new to being en pointe. When a dancer advances from the standard ballet shoe to the pointe shoe, not only is it a rite of passage, but it's a lot of physically demanding and painful work.
"I wasn't going to do pointe," Sager said. "I was kind of scared, but it really is fun."
"It's different than what I've ever done and it means a lot to me," Snyder said. "I've always wanted to be en pointe. It's really special and it means my dance life is becoming more serious."
"I've been dancing since I was 3," Moore said, "and I've wanted to be en pointe since I was 8. It's a challenge, but it's a lot of fun."
Moore went on to say that the overall choreography has changed considerably this year.
"It's really different and unique. The concept and choreography is different," she said. "For example, last time there was a lot of mirlitons and this year there's only four, and last time there was only one Spanish but this year there's five."
In most classically performed Nutcrackers, there is one lead performer with two to three supporting dancers for the Arabian, Spanish and Chinese scenes representing the Land of Sweets. Cipriano has changed that to include an entire corps or supporting dancers.
"I wanted to involve everybody," Cipriano said. "As long as (the dancers) were willing, I wanted to make sure they had a part in the first and second acts. It's not about one or two people - it's about everyone."
"Miss Amanda thinks of these ideas that most people have never heard of," Turney said. "This year we're using a guy for Mother Ginger which is more traditional and I think the audience is going to laugh and think its funny. The audience will definitely get to see different choreography."
"The children have worked very hard for five months to bring the Christmas feeling to the community," Cipriano said proudly of her students.
This production promises to be one that regular patrons of the Old Opera House have never seen before. With new costumes, new set design and yes, certainly new choreography, it's sure to be better than ever.
For more information or to purchase tickets, contact the Old Opera House box office at 304-725-4420.


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$19.95 Pricing Explained
There's an interesting Scientific American article out regarding Why Things Cost $19.95 and it delves deeper into a concept most people understand and generally regard as true. I always had thought that the purpose of pricing something at $19.95 or $19.99 rather than $20.00 was because it seemed psychologically "much cheaper" despite an actual difference of a few cents. While that may still be true, the article in Scientific American seems to paint a picture in which the impact is more subtle. If the original price is in round numbers and we try to guess the wholesale cost, our guess will be far lower than if the item were originally priced a few cents off. The $20.00 price puts our "increments" in whole dollars whereas a $19.95 price puts our "increments" in cents. The mental anchor, whether it's a round or not-round number, really set the stage for how we guess.
To be honest, I never bought the concept that $19.95 seemed psychologically cheaper than $20.00 but this explanation seems far more plausible. If your eyes see a $20.00 item and your brain unconsciously guesses it's worth $18.00, you're less likely to buy it (because you want a good deal). You're more likely to buy it if your eyes first see $19.95 and then your brain is tricked into thinking it's worth $19.45, you are paying less of a premium (despite you actually not knowing how much of a premium you're paying). The trick is far more subtle!
To extend this further, and this is now based on my experience (or perhaps I read this somewhere a long time ago) and not the article, I find that the Wal-Mart pricing structure is intended to give shoppers a sense that they are getting a deal. Now that people are tuned into $19.99 being actually $20 (or more, given sales tax), they gone to weird pricing like $19.43 and $19.57, because I think people see odd numbers and think discount! $19.99 is regular price, but if it's $18.76, it probably means it's cheaper because another retailer would probably price it at $19.95. I don't know if this is actually what happens but I bet that's what they're banking on.
What do you all think?


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Your Seattle Seahawks are the Super Bowl XLVIII Champs! Celebrate this special moment in Seattle history with this Percy Harvin bobblehead! Measuring 7.5" tall, this commemorative bobblehead looks like your favorite Seattle player. This spring-loaded bobblehead will make for a great addition to your Seahawks collection!
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Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Thanksgiving weekend was wonderful for our little family.
What is it about the 'magic' of Thanksgiving that makes even the little things seem like more fun than usual? Things like falling asleep in front of the football game...playing dress up with my daughter...having a car chase with my son...watching my husband and all the other neighborhood husbands hang up Christmas lights and grunt like Tim Taylor used to on "Home Improvement."
I realize just how blessed we are, though I am acutely aware (and very sorry) that others dread this season because of hurt relationships, loss, illness or other circumstances.
It is with this attitude of gratefulness that I stepped into the doctor's office Monday morning for my 20-week "Find-Out-The-Gender-Of-The-Baby-And-Other-Technical-Things" ultrasound.
We did not find out the gender of Olivia or Owen at their 20-week ultrasounds. Reza, my husband, didn't want to find out with this baby either, but I figured since it's our last time (please let this be our last time, please let this be our last time, please let this be our last time) that it'd be fun to do it differently. Reza took some convincing. The convincing came in the form of our 4-year-old princess, who is so excited to be a big sister again that she can hardly see straight.
I had her ask very sweetly, "Daddy, can we please find out if the baby is a boy or a girl?" and he gently said no. She took it well. A couple days later, I said, "Ask him again." So she did, and he gently said no again. She took it well, again. A couple days later, I said, "Ask him again," and I taught her how to bat her eyelashes at him.
It totally worked. He caved. I will probably regret teaching her this skill, but it always worked so well on my dad I figure she needs to know how to do this to get through life with him as her dad! (Random digression: Olivia is the spitting image of her father. I don't know if this will help or hinder her in the future as she bats his very own thick, long eyelashes at him.)
Anyway, we are finding out. By the time you read this blog, I will know if this little Noodle is a Boy Noodle or a Girl Noodle, and the name hunt will begin in earnest. Olivia has already claimed the names "Hummingbird" for a friend's baby and "Jingle" and "Fence" for the twins she will have when she's a grown-up, so those names are off the table. (Jingle will be her daughter and Fence will be her son, of course.) And to answer your question, no, it probably will not be an "O" name.
People have been asking me if I have a preference, and some reflection time this weekend has made me realize that it really, truly does not matter. I lost a baby to miscarriage a few years ago, and so my perspective is if we are blessed enough to have a third healthy child, we can legitimately enjoy either gender.
Here's to a healthy baby and second half of pregnancy...let the fun begin!
Allyson Zadeh is married with two children and another on the way! Read her weekly on Greeley Moms.
People have been asking me if I have a preference, and some reflection time this weekend has made me realize that it really, truly does not matter.


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Size16 m²
Floor No.2(with elevator)
- Internet/WiFi
- Air conditioning
- Parking available
- Breakfast
- Towels
- Pets allowed
- Elevator in building
|Wenzigova, 120 00 Prague, Czech Republic
|Property type
|Private room
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
FREE Wi-Fi
Check in time is from 14:00
Check out prior 12:00
Breakfasts from 7:00 till 10:30
Royal Court Hotel is a brand new, modern and comfortable hotel, which is located in a fully restored and renovated XIX century building of the former Royal Court. It is located in the central part near the medieval sights and the quay of the river Vltava with some of the most beautiful bridges in Europe stretching across it.
Our friendly English-speaking personnel will surround you with care and attention and will make sure you have the warmest memories of your visit to Prague.
We are pleased to offer you a classic cozy double room, which is equipped with all the necessary things for your comfortable stay. You can choose rooms with either a double bed or two large beds. The rooms are equipped with:
Shower cabin, hairdryer, towels
Shower gel/shampoo
Aroma soap for hands
Air condition
Tea set
Welcome coffee and tea
Extra services (paid):
Extra cleaning
Airport transfer
Public transport tickets
Parking for middle-sized cars costs 15-25 euro/day (at the building near apartments). The price depends on the size of your car.If you have some more questions, feel free to ask me about!
|Price for > 2 guests
|R 160 ZAR per guest/night extra
|Check-in after
|Check-in before
|On arrangement
|Check-out before
|Cancellation Policy
Perfect place beautiful city kind staff
Hi there,
we stayed 2 nights at the hotel. Everything was fine and good organized. The staff was very friendly, the hotel room was clean an sufficient.
Thx, next time again
top hotel. new Renovation
It was a very nice appartment. Everything you could need was present.
Friendly people at the reception.
Just a little out of the center but not too far
Nice room in a nice hotel. Pleople in desk were always available to help us.
They made our stay in the city much easier.
Thank you
The apartment is located relatively close to the historic center and is great to reach by public transport. It is very modern and nicely decorated and we felt very comfortable. The ladies at the reception were very nice and hilfsbereit.Einziger downside is the 4-lane street directly outside the house, if you do not but it is all too sensitive to noise, then that's not really a problem (we slept very relaxed).
In short, absolutely recommended!
Das Apartment liegt relativ nah am historischen Kern und ist super mit den öffentlichen Verkehrsmitteln zu erreichen. Es ist sehr modern und hübsch eingerichtet und wir haben uns super wohl gefühlt. Auch die Damen an der Rezeption waren sehr nett und hilfsbereit.Einziger Wermutstropfen ist die 4-spurige Straße direkt vorm Haus, wenn man aber nicht all zu Geräuschempfindlich ist, dann ist das nicht wirklich ein Problem (wir haben sehr entspannt geschlafen).
Kurz: absolut empfehlenswert!
Thank you so much; we had a great time in Prag :)
We loved our staying in this flat in Prag! The apartment was really nice, clean, modern, comfortable and indeed very well located. Even better than we expected from the photos! The personal very very helpful, nice, there was always somebody there. Very easy to get to the sightseeing points from there, walking distance to almost everywhere. The street was a bit loud, but we would surely stay there again and recommend it. :-)
Wonderful hotel,delicious varied breakfast,clean rooms,great service and professional receptionists who help in any situation :)
Thank you for nice stay!
I recommend the hotel to anyone who wants to spend time in the beautiful city!!
We had a wonderful stay in Prague. The apartment was great; very clean, big enough and the staff very accommodating and friendly! We definitely come again to Prague and will book there again our accommodation.
The parking for our car was safe and the room very centrally located in the immediate vicinity.
In the neighborhood there are shops directly, reasonably priced restaurants and a tram and metro station.
As the road "Legerova" and a four-lane busy road is, you just must not be sensitive to noise. We loved it (even with two children) did not bother. In addition, you have to open the windows for airing only because there is an air conditioner in the apartment.
A great value for money - we'll gladly come back !!!
Wir hatten einen wunderschönen Aufenthalt in Prag. Das Appartement war spitze; sehr sauber, groß genug und das Personal äußerst zuvorkommend und freundlich! Wir kommen auf jeden Fall noch einmal nach Prag und werden wieder dort unsere Unterkunft buchen.
Der Parkplatz für unser Auto war sicher und in direkter Nachbarschaft, das Zimmer sehr zentral gelegen.
In dem Wohnviertel befinden sich direkt Geschäfte, preisgünstige Restaurants und eine Straßenbahn- und U-Bahn-Station.
Da die Straße "Legerova" eine vierspurige und stark befahrene Straße ist, darf man nur nicht lärmempfindlich sein. Uns hat es (auch nicht mit zwei Kindern) überhaupt nicht gestört. Außerdem muss man die Fenster nur zum Lüften öffnen, da sich im Appartement eine Klimaanlage befindet.
Ein tollen Preis-Leistungsverhältnis - wir kommen GERNE wieder!!!
- Quality assured accommodation
- Every host is verified by telephone
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Swiss Travel System tickets have been specially designed to accommodate the individual wishes of international guests. Tickets such as the Swiss Travel Pass include unlimited travel on all public transport throughout the country, a 50% price reduction off most mountain railways and cableways as well as free admission to more than 490 museums nationwide. Spectacular scenic routes such as the Glacier Express, Bernina Express and Wilhelm Tell Express are included, plus public transportation in 75 Swiss cities, travel on Switzerland's waterways and much more.
TransferVisitors from abroad benefit from the Swiss Travel System from the minute they set foot in the country. Comfortable connections ensure safe and trouble-free travel from arrival airport or train station to their MICE destination and back – with just one single ticket, the Swiss Transfer Ticket.
Pre/Post toursTo get the most out of their stay in Switzerland, your clients could ad an exciting weekend to their meeting. Swiss Travel System tickets embrace all the fun and flexibility of the country's public transport system and are perfect for post and pre-convention tours. Whether it's a relaxing journey in a panoramic train or a breathtaking trip by mountain railway or cablecar. For groups of 250 or more passengers, customized ticket arrangements are available at a special price.
Charter trainsLet your clients make maximum use of their time before their first MICE meeting. The exclusive «Salon de Luxe» conference carriage brings your clients directly to their MICE destination. Furnished with inviting armchairs and sofas, spacious tables and state-of-the-art technical facilities, this special carriage will not only impress the visitors but ensure their preparations are on track right from the start. Please contact us for any details. www.swisstravelsystem.com/meetings
Trovate il biglietto giusto per voi


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|Movie Name
|Viewing Progress
|Run Length
|Spy Kids: All the Time in the World
|90 min
Spy Kids: All The Time In The World In
- Air Date:
- On the surface, Marissa Cortez Wilson (Jessica Alba) has it all...married to a famous spy hunting television reporter, a new baby and intelligent twin step kids. But in reality, trying to mother Rebecca (Rowan Blanchard) and Cecil (Mason Cook), who clearly don't want her around, is her toughest challenge yet. Also, her husband, Wilbur (Joel McHale), wouldn't know a spy if he lived with one which is exactly the case - Marissa's a retired secret agent. Marissa's world is turned upside down when the maniacal Timekeeper (Jeremy Piven) threatens to take over the planet and she's called back into action by the head of OSS, home of the greatest spies and where the now-defunct Spy Kids division was created. With Armageddon quickly approaching, Rebecca and Cecil are thrust into action when they learn their boring stepmom was once a top agent and now the world's most competitive ten year olds are forced to put their bickering aside and rely on their wits. With a little help from a couple of very familiar Spy Kids, Carmen (Alexa Vega) and Juni Cortez (Daryl Sabara), and some mind-blowing gadgets, they just may be able to save the world and possibly bring their family together while they're at it.
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Important delivery notice
The products on this site are only delivered to UK addresses. If you require delivery to another country please visit one of our other sites below.
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You'll find plum trees, cherry trees, peach trees and many more in this range of stone fruit trees. Patio fruit trees are ideal if you're short of space, but still want to grow your own tasty fruit. All our fruit trees are grafted on to fruit rootstocks to ensure the best quality trees and fruit crops. Read our handy 'how to grow fruit trees' guide to help you choose the best fruit tree for your garden.
added to your basket.
Plum 'Full Season Collection'
Prunus domestica
Plums are delicious eaten fresh, or made into a plum crumble or jam. As supermarkets are reluctant to offer the best tasting varieties due to thin skins and bruising, growing your own is the best way to enjoy the real flavour that this fruit can offer.
Plum 'Full Season Collection' are grafted onto a semi-dwarfing rootstock, to produce compact, productive trees. Although these varieties are all partially self fertile, when planted together they will aid pollination and increase yields between each other for an extended cropping period from July to September. Height and spread: 3.5m (11'). Rootstock: St. Julien A.
Estimated time to cropping once planted: 2 years.
Useful links:More info
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For the second time this season and for the sixth time in her career, Stetson University women's basketball senior guard Victoria McGowan (Inkster, Mich.) has been named the Atlantic Sun Conference Player of the Week, the league announced on Tuesday.
McGowan averaged 21.7 points, 7.3 rebounds, 3.7 assists and 3.0 steals while leading the Hatters to three A-Sun victories last week.
At Kennesaw State on Wednesday, McGowan scored a career-high 33 points, including 20 in the second half, to help Stetson rally from a late 12-point deficit. She scored eight of those points over four consecutive possessions as the Hatters went from trailing by five to leading by three.
McGowan's 33 points was the most by a Hatter since Nefertiti Walker scored 35 points vs. UNF on Mar. 2, 2006. It also ranked as the sixth-highest single-game points-total in school history and tied for the highest points-total for a Hatter in a road game. McGowan added to her stat line with 10 rebounds and a 15-for-17 performance from the free throw line, coming just one free throw shy of the school record in that category (16).
McGowan was held to five points in 19 minutes of action against UNF on Saturday, but the Hatter senior put forth a 27-point performance behind 11-of-17 shooting against Jacksonville on Monday. She hit five three-pointers on just seven attempts (.714), while adding six rebounds, six assists, and four steals.
A Sports Management major, McGowan leads the conference in scoring (18.1), three-point field goals made (33) and three-point field goal percentage (.478). She also ranks among the league leaders in field goal percentage (second), assists (third), and steals (fourth). Her three-point field goal percentage currently ranks her among the top 10 three-point shooters in the NCAA.
McGowan is the only player in school history and just one of 11 in Atlantic Sun history to earn the league's Player of the Week award six times.
Stetson (11-4, 4-0 A-Sun) has now won seven straight games overall and 12 straight at home. Currently tied for first in the league standings, the Hatters will look to stay hot on the road this weekend as they visit USC Upstate at 2 p.m. Saturday and ETSU at 7 p.m. Monday.
Note: On Monday, McGowan was named College Sports Madness A-Sun Player of the Week for the third time this season.


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on May 23, 2013 - 12:04 PM
, updated May 23, 2013 at 5:52 PM
LEWISTON – Damages are estimated at $2 million or more in a fire which destroyed a paper recycling facility at Modern Landfill Corp. on Pletcher Road Wednesday evening.
"The recycling building appears to be a total loss. The structure is gone," said Gary Smith, Modern's chief operating officer. Operations will be moved to Lockport facility.
He said the 80- by 120-foot building located just inside the property on Pletcher Road was used mostly for paper and cardboard recycling and as a transfer station to move other local curbside recycling materials to the company's facility in Buffalo.
According to police, an employee noticed smoke around 6 p.m..
More than half a dozen fire companies responded to the rapidly spreading fire. However, firefighters were able to contain the blaze to the single building.
"It really took off," Smith said of the fire. "The nature of the product in there, with the dust from the fine paper and such, was quite an accelerant.
"The fire companies did a terrific job. I couldn't speak more highly of their actions."
"The first fire agency that got there reported heavy smoke," said Lewiston Police Chief Christopher Salada. "They fought it for a while."
Salada said crews were on the scene for several hours.
The cause of the fire remains under investigation, but Smith said they believe something hot came in from their curb side recycling and was smoldering.
"We know about where it started, but I don't know if we will ever know the real cause. We think something was hot in that load and it smoldered and caught on fire. That's what we are envisioning," he said.
One employee was treated and released for smoke inhalation, according to Smith.
Smith said everything in Lewiston and west of Lewiston went though the site and beginning Friday morning all the trucks, about ten trucks a day, will be transferred to the company's facility on Junction Road in Lockport, where some recycling is already being done.
"This is for the short term and then we are going to reevaluate what our needs are. We will be rebuilding, but we just need some time to determine what we need the most out of that facility," Smith said.
email: firstname.lastname@example.com


text:
Seasonal scrubs, soaps, and natural body care products Up to 50% off at ACTZ Store
Deal ended at 12:12 AM on 12/05/2012
You Save$10
Ending: 00:00:00
Why You Should Grab: Winter's upcoming arrival might tempt you to pull up your turtleneck and hide your face inside a heavy scarf. But please, resist the urge to let your skin hibernate. Instead, protect it with the luxurious, all-natural body and skin care products from ACTZ Store.
What to Choose:
- $10 for a Pumpkin Patch Scrub ($20 value)
- $15 for $25 toward Any Goods
Why You'll Love It: This whimsical online store features a wide array of natural body care products along with their own line that's made with raw materials purchased at Fair Trade. In fact, two of the four cosmetics makers on staff are devoted to creating a special vegan line of soaps, scrubs, lotions, masks, and more.
What You Should Buy: Browse their selection of all-natural body mud, face mask, soap, body mists, hair care, lotions, soaks and much more. Or try one of their seasonally-appropriate products like the skin-softening, complexion-brightening, antioxidant-packed Pumpkin Patch Scrub.
Redemption Instructions
- Please click here and put items in your shopping cart.
- Continue to checkout, entering your voucher code in the "coupon code/promotional code" box on the checkout page.
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- Complete checkout by entering all shipping and billing information.
Fine Print
- Only 1 per customer, but buy 2 for your friends.
- Limit one voucher per order.
- Voucher must be used for option purchased only.
- Tax not included.
- Shipping not included: Flat rate $6 shipping inside the US.
- Free shipping on orders of $99 or more.
- Cannot be used in conjunction with other deals.
About ACTZ Store
ACTZ Store
ACTZ Store 7623 pickering ave
whittier, CA, 90602 Phone: (562) 833-6110 Get Directions
whittier, CA, 90602 Phone: (562) 833-6110 Get Directions
40% off a $25 Voucher toward Any Goods
You Save$10
50% off a Pumpkin Patch Scrub
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40% off a $25 Voucher toward Any Goods ( Value $25 )
50% off a Pumpkin Patch Scrub ( Value $20 )
50% off Two Witch's Brew Soapy Cupcake ( Value $12 )
The deal is over


text:
Nancy Forde
Academic Administrative Assistant
Contact InformationEmail: email@example.com
Phone: 519-884-0710 ext.3968
Office Location: DAWB 5-120
Office Hours: 8:30am until 4:30pm Monday through Friday (unless otherwise posted on the door)
Academic Background
B.A., Joint Honours English and Drama, University of Waterloo;
Web Design Specialist Diploma, triOS Business and Technology College
Summer School in English Literature, St. Catherine's College, Cambridge University
Summer School at the Royal National Theatre, London, England
Instead of waitressing like every other actor on the planet, I worked many years of temporary senior executive assistance in Toronto's financial district while juggling theatre and film gigs in that city. Pursuant to that, I ran my own freelance desktop publishing business for a few years from home before moving back to the Waterloo area. I then assisted the Publisher of The Record, Guelph Mercury and Cambridge Reporter. This was followed by three years as Marketing and Web Associate for an environmental technology firm in the north end of Waterloo.
I joined Wilfrid Laurier in January of 2006 and have previously assisted both the Departments of Kinesiology and Physical Education and English and Film Studies. I am thrilled to now be a permanent part of the Global Studies "family" and its sole full-time Academic Assistant. This department is growing and energetic and the people involved (faculty, CAS, TAs and students) are all wonderful spirits who care very deeply about this planet and its inhabitants. Come visit us and see what we're all about.


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STEUBENVILLE It has been said that opposites attract. That was the case Friday night, until Big Red pulled away from the Wildcats.
The Big Red boys' basketball team scored at least 15 points in all four quarters, and Big Red led by as many as 46 points en route to a 71-27 win Friday over visiting Jefferson County rival Edison at the Crimson Center.
With the win, Big Red improves to 4-2 on the season. With the loss, the Wildcats drop to 1-6.
Edison coach Nate Moses declined to comment.
The Wildcats came out and wanted to patient on offense, and Edison was successful early on as the Wildcats took an early 4-0 lead. On the other hand, Big Red wanted to get out and run up and down the floor, and after a slow start Big Red was able to just that in pulling away to the 44-point victory.
"We were chasing them while they were running their flex," Big Red head coach Mike Haney said. "We were getting behind their picks, and they were able to get off to a good start."
Fact Box
Big Red 71, Edison 27
ED (27): Dylan Jones 0 0-0 0,Erik Lee 0 0-0 0, Strom Allese 0 0-0 0, Austin Hyndman 2 0-0 5, Ryan Kamarich 1 0-2 0, Alec Jones 2 0-0 5, JD Howell 2 1-2 5, Skylar Wilkin 0 0-0 0, Brad Spencer 0 0-0 0, Clay Woodward 1 0-0 2, Austin Horan 3 1-3 7, Josh Noika 0 0-0 0, Tyler Schmidtt 0 0-0 0. Totals: 11 3-9 27.
BR (71): John Linn 2 2-2 7, Brandon Herring-Hill 3 1-2 7, Vontrell Bailey 1 0-0 2, TaJuan Lawson 5 2-3 14, Lucas Herrington 1 0-0 3, Mylik Young 5 4-4 14, Adam Sterling 5 1-1 11, Dashon Redman 2 0-0 4, Chris Smith 2 0-0 4, Glenn Purdue 2 1-2 5. Totals: 28 11-14 71.
3-Pointers: Edison: 2 (Hyndman, Alec Jones); Big Red: 4 (Lawson 2, Linn, Herring-Hill)
The Wildcats gained the early momentum on baskets by JD Howell and Ryan Kamarich, but it did not last long. Big Red scored the next 18 points en route to taking an 18-7 advantage into the second stanza.
The 18-point spurt was just one of several runs by Big Red throughout the course of the night.
"Once we made a basket, we were able to get into our full-court pressure, and we were able to cause some turnovers," Haney said.
Austin Horan netted a team-high seven points to lead the way for the Wildcats, while Austin Hyndman, Jones and Howell each tallied five points.
Also for Edison, Clay Woodward and Kamarich each contributed two points and Storm Allese added one.


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Police: Orlando man threatens to chop teenager's head off
Man charged with aggravated assault
Published 2:17 PM EST Jan 16, 2013
Orlando police arrested a man Tuesday after he threatened to chop a 16-year-old's head off, police said.
Investigators said the victim asked 63-year-old Miguel Baez to keep the noise level down in his room at the Home Suite Homes on East Colonial Drive.
Baez then told the victim he would chop his his head off with a machete that he had on him, according to a police report.
Police said they searched Baez's room and found the machete along with 22.5 grams of marijuana.
Baez is charged with aggravated assault with a deadly weapon, possession of cannabis and possession of drug paraphernalia.
Florida mug shots: Jan. 16
Copyright 2013 by WESH.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Beef at Boston Marathon
Contact: , 308-697-3486;
The checkoff's Northeast Beef Promotion Initiative (NEBPI) is gearing up for the 117th Boston Marathon and is currently looking for runners to join Team BEEF.
The Beef Checkoff Program was established as part of the 1985 Farm Bill. The checkoff assesses $1 per head on the sale of live domestic and imported cattle, in addition to a comparable assessment on imported beef and beef products. States retain up to 50 cents on the dollar and forward the other 50 cents per head to the Cattlemen's Beef Promotion and Research Board, which administers the national checkoff program, subject to USDA approval.


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- Knit and Chat with Pat and Friends
Tuesday, October 15, 2013 | 4:30 pm - 5:30 pm
Bring a current project to work on while we share cozy conversation about books. Non-knitters welcome. We offer basic instruction and materials, or just come for the conversation. Drop in.Grades 3-6
4:30-5:30 p.m.
Tuesdays: October 15 and November 19
Childrens Program Room
No Registration Required
MCPL Childrens Services
Contact Number:
(812) 349-3100
Christina Jones
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Top Definition
Sorry I couldn't answer the phone... I was beatin' cakes.
Por Shando 27 de enero de 2004
Trending Now
Can you define these popular missing words?
When a man rigorously pounds the vagina area.
So you went out with Molly last night? Did you beat cakes?
The cougar needed a good cake beating.
The cougar needed a good cake beating.
Por Jerry Fuctentoast 12 de febrero de 2010
good beats or tracks that are hot, fresh, current, new, yet to be released
I need some serious beatcakes for my playlist; nothing I got is hot anymore.
Por Tohubohu 19 de febrero de 2009
Chad, Kevin, and DJ went to beat cakes on the streets of seattle the previous weekend.
Por beat cakes 20 de marzo de 2009


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Wednesday, March 13, 2013
Stroll the Historic Old Village of Mount Pleasant on Sunday, April 21 from 1 to 5 p.m. on a self-guided Home, Garden & Art Tour.
This wonderful event has become a welcome springtime traditions for hundreds of participants.
Ticketholders will visit Old Village homes, sample food prepared by local chefs, listen to music and view art created for sale by local artists.
This year will again feature an exclusive array of area restaurants and caterers as a centerpiece of the weekend. New this year is "Ask the Garden Expert" on hand to answer your questions and offer advice.
Tickets are $45; $35 for groups of 10 or more.
Proceeds from the Old Village Home, Garden and Art Tour support the American Red Cross, Carolina Lowcountry Chapter, located in Charleston.
Visit the website at www.lowcountryredcross.org or firstname.lastname@example.com for more information and to purchase tickets prior to the event..
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The obvious benefit of having a laptop computer rather than a desktop is that you can take it anywhere. To take full advantage of that perk, however, you need something to carry it in. A good case will protect your laptop against damage from water and accidental bumps, while at the same time distributing its weight to make it easier to carry. It will also provide space for your laptop's accessories, such as a charger, and other gear you carry on a daily basis, from pencils to water bottles. With the right case, you can just grab one bag in the morning and go.
The most traditional-looking laptop case is essentially a briefcase, often made of leather, with additional padding inside to help protect the computer. Laptop briefcases are sleek and professional-looking, but they're also awkward to carry. Although laptops are lighter than they used to be, carrying the full weight of one -- along with papers and other paraphernalia -- in one hand can get pretty tiring if you're going more than a short distance. Most laptop briefcases add a shoulder strap to help distribute the weight, but they're still not as ergonomic as other styles.
Messenger bags and backpacks, which can be worn as well as carried, are the most popular styles for laptop cases today. Messenger bags have one long strap that can be worn on either shoulder or across the body. A large front flap makes contents easy to access. Notebook backpacks have a separate compartment or sleeve to protect the laptop computer, plus one or two other compartments for additional supplies. They're a bit informal for some business settings, but they're ideal for commuting by bicycle. We found that the best-rated laptop backpacks and messenger bags typically cost between $200 and $300, with messenger bags leaning slightly toward the lower end of the range.
In addition to these major styles, there are a few less common ones. Laptop totes are shoulder bags, often made of unusual materials or sporting contemporary designs. They typically contain a padded compartment or a removable protective sleeve to protect the computer while it's being carried. (You can also separately buy laptop sleeves.) Tucking your notebook computer inside one of these protective covers allows you to use any kind of large bag as your case. However, we didn't find nearly as many recommendations for these types of cases as we did for laptop backpacks and messenger bags.
Because there are thousands of laptop cases on the market, finding clear-cut consensus among reviewers is a challenge. Although most major computer publications have reviewed at least a few of the available models, very few are covered in more than one source. To ferret out the best bags, we hunted through all the reviews we could find on gadget-oriented sites -- as well as reviews from users at retail sites -- looking for laptop cases that earn praise from more than one source. Based on this research, we've identified two backpacks and two messenger bags that consistently receive high marks for their features, durability, carrying comfort and style.
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- Contact: Lauren Willis
- Phone: 512-463-4070, Toll-free: 1-800-531-5441 ext. 3-4070
For Immediate Release
March 14, 2012
Comptroller Susan Combs Touts State's #1 Transparency Ranking
(AUSTIN) — Texas has received the top ranking for government spending transparency in an annual report on all states issued by the U.S. Public Interest Research Group (U.S.PIRG). The state's Texas Transparency website is developed and maintained by the office of Texas Comptroller Susan Combs.
"I'm proud to be at the forefront of setting standards for government transparency and we will keep striving to improve our initiatives," Combs said. "From the time I took office we have worked to expand our transparency efforts to provide taxpayers online access to multiple levels of state spending and financial information. Taxpayers have the right to know how their money is spent and transparency ensures government is held accountable to the people it serves."
The Texas Transparency website is at www.texastransparency.org. U.S. PIRG noted the comprehensive financial information the website provides along with historical check-register level detail that is downloadable. The Comptroller's office also provides information on local government transparency on its website and encourages local governments around the state to launch financial transparency initiatives.
U.S.PIRG did an extensive state-by-state analysis as it pushes for higher standards of government transparency. The group's Following the Money 2012 report can be found at http://www.uspirg.org/reports/usp/following-money-2012.
Join the discussion and connect with the Texas Comptroller on Facebook for the latest economic news, surveys and more.
Follow us on Twitter! Get quick Comptroller news and information you need to do business in Texas.


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Source: The State of California
quote: It's just more California idiots trying to set "standards" for the rest of the country, as usual.
quote: Even if you squeeze the cars closer together, in 5 years once another 10 million or so Mexicans fence-jump their way into CA and the idiot lawmakers allow them to obtain licenses, you're back to square one.
quote: We have an entire class of people that will NEVER be able to afford these types of cars.


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The decision of the Cyprus government to take money from people's bank accounts has us wondering … "Can this happen here?" Their finance minister stated that depositors with over $129,000 could possibly see as much as 80 percent of their money seized. As more European countries fail and declare bankruptcy we wonder if the same scenario will apply to us if our government doesn't get its finances in order.
Bankruptcy is already occurring in U.S. cities with Stockton being the latest to file. The "Golden State" has accumulated $164 billion dollars in obligated debt, in spite of the fact that California is the highest taxed state in the nation. Obviously higher taxes aren't the solution to out-of-control spending.
The United States is nearly $17 trillion dollars in debt and every man, woman, and child in the US owes the government $55,000 for their share of that debt. With almost half of our households receiving some sort of government assistance we are on our way to insolvency if we don't concentrate on job creation and a healthy productive private sector. Instead of ever-increasing taxation, the Obama administration needs to focus on spending, tax, and entitlement reforms. Without these reforms, we could become Cyprus.
Nancy Brost
Nevada City


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One man says his peppy pooch went too far and had to be rescued from a Central Florida lake.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Tuesday, August 20, 2013
Ashley Ridge receiver Donavan Thompson is stepping out of the shadows.
Thompson split time between the Swamp Fox JV and varsity teams his freshman year. As a sophomore he joined the varsity fulltime and began getting starts. Last season he was the team's third leading receiver, averaging more than 18 yards per catch.
However, Thompson's achievements were sometimes overshadowed because he played on the same offense as standouts like Romelo Doctor, Vernon Moree, Seamus McKinney and his brother, Jacob Thompson.
This year, the receiver is hoping to play an even larger role.
"The last two years my role was more to do my part to help those guys but I think now my time has come," he said. "I'm excited about the season and doing everything I can to help us win. My main goal this season is for us to finish with a winning record."
Despite having its share of standout athletes, the Swamp Fox football team struggled last season and finished with a 4-8 record. Thompson is convinced this year's team can do better.
"This team has a whole bunch of potential and everyone is one," he said. "Last year, it felt kind of like everybody was separate and everybody wanted to do their own thing but this year it's different."
Thompson says this season the Swamp Fox team has strong leadership.
"Kendall Felder is a guy who no matter what, he has your back," Thompson said. "If you need him, he'll be there. Sean White is a guy who can push his teammates through anything. For me it is reassuring to have someone like Tyler Moss in front of me on the line. He is strong and I know he will open up holes."
Thompson is hoping the work he and teammates put into the summer conditioning program will pay off this fall.
"Our conditioning this summer went great," he said. "They changed our weight lifting program and our conditioning workouts were longer. I think we are faster and stronger than we were last year. That should make it easier to pull out some of those tight games. I know I'm more prepared so I'm sure everybody else is as well."
Contact Roger Lee @ 873-9424 ext. 213 or firstname.lastname@example.com
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Many delegates voted against secession from Union
March 26, 2013
When President Lincoln called up troops on April 15, the stance of many of the Virginia convention delegates changed....
Lincoln's only mistake was allowing McClellan to continue as General of the Army of the Potomac after the Peninsula Campaign. Lincoln committed many wartime acts that should be question including suspension of habeous corpus. However, his decision to preserve the Union at all costs is not in question.
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Wilkes was determined to kill Lincoln. If it would not have been on April 15(no goggle needed for that date) at Fords it would have been happened later.
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Other than that Mrs Lincoln, how did you like the play?
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Not very funny even 150 years later and considering she went insane after especially not funny.
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Lincoln had the pro-Confederate members of the Maryland Legislature arrested by Federal troops in nearby Frederick, MD on August 7, 1861. The general feeling was that Maryland wanted to remain a Neutral state during the Civil War. If that happened DC would have to be abandoned and the capitol relocated to Philly or NYC (again). The Fed's couldn't have a CSA state to the South and a Neutral one to the North. Historically 'First Blood' was drawn on Pratt Street in Baltimore when the 6th Mass moving between rail stations were attacked by a mob. 4 soldiers and 12 civilians were killed. If you go to Federal Hill in Baltimore above the Inner Harbor you'll not that the lone cannon on the hill still points to Pratt St. Federal Hill was a Federal encampment not for the defense of Baltimore but for the suppression of the city. The jailed representatives ended up jailed in the National Historic Shrine at Fort McHenry (the Baltimore Bastille) without charges or trail
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Trial that is... I still say for me this board needs an edit feature and a spell check.
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The imprisoned included Francis Scott Key's grandson, Francis Key Howard. Others included: George William Brown, the Mayor of Baltimore. Police Commissioner George P. Kane. Several newspaper editors and owners critical of Lincoln. Maryland political figures SUSPECTED of being Confederate sympathizers. But here's the deal Article 1, Section 9 of the Constitution reads "The privilege of the writ of habeas corpus shall not be suspended, unless when in causes of rebellion or invasion of the public safety may require it.' So was Lincoln wrong to suspend the Writ of Liberty? Was the public safer due to his actions - I think not. Virginia voted not to secede from the Union until Lincoln called up troops to attack those Southern states that did break with the Union. An avoidable internal war that resulted in ~3/4 of a million deaths (mostly from disease) and ~400,000+ wounded in action.
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This article is essentially false. Hasn't any West Virginia historian EVER looked at the Ordinance of Secession itself? The signatures of 28 West Virginia delegates are on it. Benjamin Wilson signed the April copy of the Ordinance but was arrested in June before he could sign the June copy, so a total of 29 of West Virginia's 49 delegates signed on to Virginia's secession from the United States. West Virginia's Civil War history is totally distorted and needs to be re-writted from the ground up. Francis Pierpont told Lincoln directly that West Virginians were against statehood "The Union men of West Va were not originally for the Union because of the new state." That is a direct quote and the telegram is in the Library of Congress.
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LeapFrog Explorer™ Learning Game: Mr. Pencil Saves Doodleburg
- Color:
- multi
- 1
- 2
Description: To help improve your child's mathematical skills, get the Leapfrog Explorer Learning Game. It teaches your child how to write numbers, letters, shapes, and create art while helping Mr. Pencil and his friends rescue the town. This explorer game is well suited for children between the age group of 4-7 yrs and enables them create their own drawing and art using fun colors, tools, stamps, effects, and filters. Your child can even become an animator by creating his/her own flip book. Since the game adjusts its curriculum dynamically according to the skill level of the player, it is neither too hard nor too easy to play. The Mr. Pencil Saves Doodleburg Leapster Game is compatible with the LeapPad Explorer and Leapster Explorer systems.
- Help save the town by writing letters and drawing lines, shapes and objects
- Create your own art using cool tools, colors, filters, stamps and effects
- Become an animator by creating your own flip book
- Teaches letter writing, number writing, shapes and art and drawing
- Parents can connect to the LeapFrog Learning Path to see what their child is learning
- Recommended ages 4 to 7 years
Although we can only offer these items at full price, we love the products and are excited to bring them to our members.
Brand: LeapFrog


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LC-MS Gains Favor Due To the...
As Immunotherapy Revolutionizes the Cancer Treatment...
NSCLC is "Major Battlefield" as Merck,...
Wall Street Decline Takes Its Toll...
DSM says its XD® technology can allow scientists to maximize output from disposable bioreactors.
Biologic drugs including monoclonal antibodies, therapeutic proteins, immunotherapies, and vaccines have transformed the treatment of many diseases. Given their therapeutic and commercial success, the pharmaceutical industry has invested heavily in these molecules, and, by all estimates, markets for current and novel therapeutic proteins will continue to increase.
In a report published in 2005, disposable bag technologies, used for media storage, process development, seed inoculum, and as the actual bioreactor vessel itself, were predicted to develop into important tools in therapeutic protein manufacturers' quest for ever increasing efficiencies. Multiple factors have driven this quest for efficiency, particularly the realization that cost savings in manufacturing biologics would drive their adoption and acceptance globally.
Biologics sales are set to reach about $166 billion by 2014, with the global market for monoclonal antibodies alone expected to rise at a compound annual growth rate (CAGR) of 5.3% to nearly $58 billion in 2016. The U.S. market remains the largest single market for therapeutic monoclonal antibodies, rising from nearly $19.8 billion in 2010 to reach $20.1 billion by 2011. It is further projected to grow to $27.4 billion by 2016, a CAGR of 6.4%.
Historically, biopharmaceutical production has relied on space-consuming, hard-piped equipment including fixed, large stirred-tank stainless steel bioreactors and tanks to hold product intermediates and buffers. But their inherent inflexibility as well as the requirement for large capital expenditures for these systems has diminished their utility both in response to volume demand, and in meeting changing market conditions.
For example, biopharma manufacturers need to maintain production capacity for large volume protein therapeutics needed in large doses over long periods of time such as monoclonal antibodies.
At the same time, new personalized protein therapies targeting fewer patients will require small batch production. Newer protein medicine may also be much more potent, reducing requirements for large batch production. Further, national security needs for systems that can easily and rapidly respond to biological attacks or rapid vaccine production from fast-moving epidemics and pandemics will further drive the need for campaign-based production schemes.
Biopharmaceutical manufacturers have met the demand for greatly increased volumes of protein therapeutics by improving conventional technology process productivity. Commercial products have expression levels in the range of 0.2–3.0 g/L with the highest titers seen for monoclonal antibody products. These technologies, including higher expression levels, improved and optimized media, and enhanced bioreactor conditions, have greatly increased biotherapeutic production without sacrifices in quality.
But facilities struggle to keep up with demand for existing product and match downstream capacity with bioreactor output. Technologies enabling higher bioreactor titers have created downstream processing (DSP) bottlenecks and limitations on equipment throughput.
And the inevitable development and introduction of biosimilar molecules will add to these pressures. CellTrion and Hospira submitted biosimilar antibody approval applications to the EMA in 2012, with the expectation that those products will be launched in the European Union in 2014. By 2023, it is predicted that biosimilar monoclonal antibodies and insulin products will account for 57% of the global biosimilars market.
The cost and complexity of developing and manufacturing biosimilars also suggests that, realistically, product pricing reductions will be 20% to 30%, compared to the 80% typical for small molecule drugs. These relatively low margins, combined with pressure from healthcare systems on end-user pricing, will require less costly manufacturing alternatives than the big tank approaches now widely in use.
The need for multiproduct facilities, with increased flexibility, reduces the requirements for expensive critical utilities such as water for injection and clean steam, decrease requirements for equipment cleaning and cleaning validation, lower capital investments, and shorten facility construction times.
All of these realities have caused biopharma manufacturers to incorporate disposable or single-use process technologies into their product manufacturing. These systems offer a smaller footprint, flexibility, scalability, and mobility without compromising product quality.
Compared with conventional bioreactor systems, single-use solutions have other advantages, including reduced cleaning and sterilization demands, with some estimates tallying cost savings of more than 60% with these disposable systems compared to fixed asset stainless steel bioreactors.
In pharmaceutical production, single-use bioreactors simplify complex qualification and validation procedures. Use of single-use bioreactors reduces the risk of cross contamination and enhances biological and process safety. Single-use applications are especially suitable for any kind of biopharmaceutical product.
Large protein therapeutic contract manufacturers have adopted the technology to produce biologics. For example, Laureate says it uses disposable components and single-use bioreactor systems to provide a number of quality, operational, and economic advantages. The company says that because system components arrive precleaned and sterilized, the need for cleaning and sterilization process steps is eliminated.
The reduced operating costs, smaller footprint, increased productivity, and rapid turn-around time associated with disposables are some of the major benefits that are pushing Laureate and others in the biopharmaceutical industry toward single-use technology in manufacturing
While the technology remains relatively new, manufacturers that use disposable bioreactors across the manufacturing process have steadily increased, including Lonza's use of GE Healthcare's Wave bioreactors in the inoculum train for large-scale production bioreactors and Shire's use of single-use bioreactors and other disposable technologies in the upstream portion of its ATLAS commercial manufacturing facility.
Companies are now considering facility designs that incorporate disposables at all stages of manufacturing. DSM has introduced its XD® Technology and is opening a single-use bioreactor based facility in Brisbane, Australia, to support very high-density mammalian processes where, it says, increased bioreactor output and yield per volume can be increased 5–15 fold.
Several factors have driven this adoption, including technology improvements such as those provided by Xcellerex (now part of GE Healthcare Life Sciences), Thermo Scientific HyClone, and Sartorius Stedim Biotech. These platforms consist of a fixed support containing process-control software that is installed in a production facility. The disposable bioreactor consists of a single-use bag that can be inserted into that support structure, with agitation provided by a disposable impeller that attaches to a motor in the support structure. Feeding, pH, and dissolved oxygen are controlled through installed ports and probes.
Key the development of disposable reactors was cell culture in a plastic bag mounted within a cylindrical frame to support the bag. Hyclone was the first market entrant with its Single Use Bioreactor (SUB) system, which used a top-driven impeller for mixing and agitation. Xcellerex introduced its XDR disposable stirred tank bioreactors featuring magnetically coupled bottom-driven agitators.
Recently, DSM introduced its XD® continuous feed technology that allows a current maximum cell density of 242 million cell/mL, with a bioreactor output and yield per volume of 12 g/L for proteins and 27 g/L for antibodies. This system also continuously removes metabolites during cell culture.
Both cell culture processes and product quality, several studies have shown, are comparable in single-use bioreactors and same-sized stainless steel reactors.
Due to their advantages, adoption of single-use bioreactors will continue to increase. Facility optimization for multipurpose product manufacturing including personalized cellular therapies (T-cell expansion), recombinant "replacement" enzymes, unique mAbs requiring smaller batch sizes, and the evolution of cell-based vaccine production (whether in adherent cells or on microcarriers or cells in suspension), will necessitate further employment of single-use bioreactors.
In summary, market forces will push protein therapeutic manufacturers to adopt disposable technologies across the biomanufacturing process. Experts predict that by using local manufacturing facilities, modern, state-of-the-art manufacturing technologies, and efficient manufacturing approaches including single-use technologies, the international biopharmaceutical industry can meet these challenges and improve healthcare options worldwide.
Patricia Fitzpatrick Dimond, Ph.D. ([email protected]), is technical editor at Genetic Engineering & Biotechnology News.
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And not one of his pieces that he shared was a portrait of himself, literally, but there was no doubt it was him.
I am in every picture I take. I am the reason these photos even exist. Just because you can't see my face doesn't mean that I am not there. I felt the moment, captured it, I was there. That is me. The mom is in the picture. Of course I want my kids to have photographic evidence of their mother through the years, and they do, and will.
They also have all my words, a more accurate reflection of me than any photo could ever be.


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The USFSA announcement of his withdrawal from TEB also cites his injury.
I agree galina is not right for Johnny tho I loved many of Victor's pro programs. Johnny is stale and his Gaga is a retread. Also agree they look like show programs, not CoP. I think it is hard for someone to step out of the limelight gracefully and move on. Even MK fans felt 2004 Tosca was her last great skate and pushing thru injury to 2006 was only about the Oly medal, and with the rapid rise of Arakawa and the possibility of Irina and Sasha medalling-it was not likely even MK would have podiumed. Johnny may have a somewhat consistent quad, or not, but he is a nervous competitor.
It is always about attention with Johnny. I like Gaga's original piece of music-orchestrations of so-so pop don't always make good sp. But he has done these show prorams so many times to her music. I think Nationals will be his final swan song, as it was for Sasha. He skated beautifully in Vancouver-pure Johnny. It seems that he should have moved on with a very nice skate-even though it was more 6.0 in composition. He has fame, what more?
Does anyone know his LP music?
I think Galina is stale. And Johnny was given the music by Lady Gaga who is a personal favorite of his. That can be heady stuff when a big celebrity wants you to use her music. But I totally agree that it's a retread....especially without the makeup and weird costume (which thank GOD he did not subject us to in competition) I don't mean to keep defending him but skating beautifully in Vancouver sure didn't get him anything. I can see why he felt he wasn't finished. I think he got robbed. Not saying he should have got a medal but at least 4th would have made more sense to me. The composition of his programs and transitions, etc. are pretty much all on the choreographer and coach. I think Johnny has some great skating left in him. I wish wish wish he had moved to another coach with a little more current skating knowledge. To me Galina is a 6.0 coach!
I don't think Galina takes coaching Johnny all that seriously. If you saw the fluff of Baiul training under her, Galina coached her with an iron fist. She controlled every aspect of her training, choreography, and competition preparation. I think Johnny has a lot more control of the coaching situation, and Galina seems happy to help him out.
Possibly - but how many years ago was Oksana Baiul? 1994? That's 18 years ago. And Galina is in her early 60's I think. You have alot more fire in you at the age of 38 or so than you do at 62. Just saying. I'm not dismissing the concept that she's just in it for the money, but to hear Johnny talk she bosses him around pretty good. In any case - a change would have been nice.
I'm sorry but I remain confused....I understand that Weir didn't finish CoR and now has withdrawn from France. So my confusion is....does he now loose his bye to nationals? Thanks in advance!
So yes, no doubt that Johnny Weir was assigned to COR, which conflicted with Eastern Sectionals. The question is whether completing just the SP in said competition counts. I say it was because he did travel to the competition and tried to compete in good faith at COR. (It might have been different if he withdrew from the competition beforehand)....B. The competitor is assigned to and competes in a singles, pairs and/or ice dance event in an international competition; and
C. The competition mentioned in (B) conflicts with the competitors sectional championships.
"The free is called 'Phoenix' and its pieces are by the group Escala ['Sarabande' and 'Requiem'] and violinist Edvin Marton [a Chopin selection]. I chose music I love and am inspired by. They are classics, but the way we've arranged the program nobody will think, 'Oh, I've seen this before.'"
Well, we have talked of his skating, how about his affect if any on how skating is perceived. I do not have any problem with his orientation, as as the saying Goes he was born that way, and God loves all his kids. But do you think Johnny should continue being so flamboyant? His Sp costume was toned down but still effeminate. Does Johnny help or hurt popularity of FS? It seems he has a large fan base, and I am not sure if that means he is well liked generally or in skating centers like NYC where there are 10 million very independent type people. My city would be parochial to a New Yorker, and deprssing I am sure. I don't get there so I don't really know "New York."
Is Johnny a plus or a minus now to a sport that is very small indeed in the USA at elite level. We have two comeback kids, one flashy as all getout, the other very conservative (except for the vera snake outfit.) who is well liked by the USFSA and respected generally by most skate fans if not loved. We have Adam Rippon, a beautiful stylist, who can't compete well. He dresses consrvatively -for a skater- and we have Jeremy, who is a very artistic being. We have Dornbush and Miner who are not out there with the clothes etc. I just wonder how people feel Johnny plays to the average skate fan looking for skating on TV-plus or minus? I think some of his outfits and his reality show may have given people an idea that is false, that most figureskaters are gay. I think this is not true over time and cultures, but my question is, does this matter anymore? Skating has so many critics who think it is a pageant with skimpy costumes. I don't know many people who care that skating is dying, the way we do on this and other boards.
And I wonder how he will be received at Nationals given his SP and the injury withdrawal. I sorta don't believe the injury thing as it is used when people are bombing on ice too frequently. I seem to think Johnny has lost his cache as the crazy guy with the out there quotes. He is a married man now and he seems much quieter, even dull compared to the very un PC Johnny that appealed to a lot of skate fans and folks in general. Your thoughts on his affect on mens skating in USA? Good , bad, or no real effect?
Last edited by skateluvr; 11-13-2012 at 10:18 PM.
thanks Daisy, I agree with what you feel. His prograams are quite empty by CoP standards. I did love his skate in vancouver, and I guess it was fair when there are no difficult transitions and easy footwork. But what do you feel about his influence on the skating world as a person, and his insistence on outre outfits and his posing in tights and heel, barechested with a pompadour? It seems all that got him disliked by the USFSA, then they seemed to welcome him back. Are they desperate for interest in nationals? I recall what jaime sale felt about his Russian team jackets etc.
Does Johnny portray a persona that attracts new possible fans or has he pushed them away? I realize without a poll, it would be hard to know. I can guess that many would find Trump boorish without a poll, even in NYC where anything goes, but how has Johnny affected US skating and families who think maybe skating would be good for their kid? My guess is people are now so blase since TV/internet have are saturated with non-family entertainment, my own opinion is Johnny is pretty irrelevant, and has gotten his 15 minutes of fame with shock value. I think his fan base will dwindle quite quickly. why would he get more reality shows if he cannot get to another olympics? There does not seem much interest here on GS. I think that is very telling about him becoming a has been-D listed in 2013. But I don't live in NYC. maybe he aand hubby are quite in demand. i wouldn't know.
i see him gone from skating after Nationals, and losing his fan base as he is not able to skate with the top men. i.e the comeback is a flop in more ways than one.
Last edited by skateluvr; 11-13-2012 at 11:45 PM.
I just hope he doesn't pout if he receives low scores for his empty programs because I'd hate for those in the LGBT community to think his low scores are because the judges have a problem with him being gay. Now that I know more about COP, and see the programs that score well, I realize his skating isn't suited to this judging system very much.
I think there will be no Nationals. Or again another withdrawal after another poorly skated SP (but if he somehow manages to skate a clean program and still gets poor marks - undoubtedly the marks are gonna be poor, his programs are empty - then we will hear many talks about politics, homophobia, etc., same as after Vancouver).
The problem with Johnny is that he doesn't possess a mindset of an athlete, he's not competitor. And he's not interested in winning, it seems. I have an impression that of the sport, he wants fame, whirling in TV-shows saying so-called "outrageous" things, getting attention, glamour, sparky costumes, and applauses in big arenas, and other things like that. Same things he seems to be wanting out of fashion, too. He doesn't want nor to work neither to compete. I think he managed pretty good to get the most out of life with the least of work, thanks to his talent.
As for his costumes, etc. - I think he would be very entertaining if he skated well. "Outrageous" press conferences, heels and his costumes would be much fun if there were any medals. Only champions have impact or effect on anybody or anything, in my opinion.
Last edited by adamanna; 11-14-2012 at 09:10 AM.
thanks Mrs. P


text:
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« Back to Media Releases
City of Little Rock Public Relations
Office (501) 371-4421
Contact(s):Ben Thielemier | (o) 501 371 4421 | (c) 501 804 4822
Saturday, December 7, 2013
LITTLE ROCK – The City of Little Rock Storm Team gathered at the Emergency Operations Center Saturday afternoon for an update on the continued severe winter storm response.
"Crews from Public Works and Fleet Services are working around the clock to clear streets and maintain equipment," said City Manager Bruce T. Moore. "We still encourage all residents to be very careful if they need to get out on the roads and to be especially mindful of our public works crews and emergency personnel."
Street crews have cleared at least one traffic lane in each direction on all of the main arterial streets throughout the entire city. They are now moving on to collector and distributor streets in residential areas and will move further into neighborhoods as they complete this next level of roads. Public Works has been able to purchase salt as it is used, so stock piles remain near 100 percent.
"All of our departments are closely coordinating efforts to ensure a quick return to normal operations for Little Rock residents," Mayor Mark Stodola said. "Safety is our number one priority during this winter storm clean up."
Public Works has dedicated vehicles for clearing routes to hospital emergency rooms and other essential buildings. Crews will prioritize routes to nursing homes and other facilities that need ready access for emergency vehicles.
On Monday, crews will pick up trash from both Friday and Monday routes depending on road conditions. They plan to be back on their regular schedule by Tuesday, weather permitting. Recycling pick up will follow the same schedule as trash pick up. In order to expedite trash pick up, yard waste removal will resume later in the week.
"Emergency homeless shelters in the City say there are more than 140 open beds available," said Moore. "They are also serving as day shelters while the temperatures are below freezing."
City officials and the Red Cross will continue to monitor the need to open a warming center in the City. If that need should arise, staff is on standby and ready to operate a center.
"We recommend that citizens always have non-perishable food items, bottled fresh water and batteries on hand in preparation for emergency events like severe weather," added Moore.
For emergencies, please dial 911. The City's non-emergency 311 number will be staffed for extended hours from 7:30am until 7:00pm through Monday.
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Surprising politicians who made a splash
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Take a look at political figures with the most unusual resumes.
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Expanding Use of NGS Has Largely...
Developers of DTC Genetic Testing Are...
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Wall Street Decline Takes Its Toll...
Expanded characterization of miRNAs is advancing their potential as therapeutic targets, not just as biomarkers. Eva Hernando, Ph.D., assistant professor in NYU School of Medicine's department of pathology, is assessing the diagnostic and prognostic aspects of miRNA, as well as therapeutic capacity, with a focus on melanoma metastasis. Her work is directed at using miRNAs as biomarkers to discriminate patients with primary melanomas at higher risk of recurrence, and then to be able to target relevant miRNAs, either by upregulating those underexpressed in the cancer state or functionally ablating those with oncogenic effects.
At the CHI meeting, Dr. Hernando presented results from miRNA expression arrays that associated increased miR-30d expression with advancing stages of melanoma, increased cell invasion in vitro, and with melanoma metastasis in vivo.
She too, acknowledged limitations in assessing miRNA data. Use of miRNA arrays versus qRT-PCR allows analysis of greater numbers of miRNAs but with loss in sensitivity. Array data must, therefore, always be validated, "so we perform independent validation, by qPCR, of any miRNA hits we see differentially expressed that are associated with metastases or other clinical feature of interest," Dr. Hernando said.
Her lab is working with Regulus Therapeutics, the branch of Alnylam Pharmaceuticals focused on miRNAs, to explore miRNAs' therapeutic targetability. Dr. Hernando's lab recently published proof-of-principle results in a mouse model of melanoma liver metastasis; synthesized anti-miR-182 oligos were shown to downregulate tumors and upregulate several miR-182 targets, suggesting the potential of miRNA as an antisense-drug target. She observed that efficacy in the liver has been well demonstrated but that companies must improve delivery methods for efficacy in other tissues (an area for future research).
Knowledge of the precursor steps in miRNA biogenesis affords the opportunity of creating full miRNA knockouts, which Robert Blelloch, M.D., Ph.D., associate professor in the urology department at the University of California San Francisco School of Medicine, is using to characterize prostate cancer. Cassandra Belair, Ph.D., a researcher in Dr. Blelloch's lab, presented data on miRNA signatures and their roles in prostate cancer progression.
miRNAs in plasma and other body fluids provide a readout of the disease state of a patient. The Blelloch lab has sought to further develop "highly sensitive and accurate assays" for profiling miRNAs in the sera of patients with prostate cancer, using knockouts in the biogenesis pathway to follow the accuracy of the assays. For example, removal of Dgcr8 should result in the loss of all canonical miRNAs (referring to a particular miRNA biogenesis pathways), while the loss of Dicer should result in the loss of both canonical and noncanonical miRNAs.
Multiplex PCR quantitation techniques used in commonly available kits can be "remarkably inaccurate," even showing upregulation in the knockout cells, according to the research team. Through critical modifications, they "improved on these techniques to render an accurate, high-throughput process to quantify all miRNAs." The process has been adopted to a nanofluidics PCR platform developed by Fluidigm designed for very low-volume reactions, thereby conserving both patient samples and valuable assay reagents.
In proof-of-principle experiments, these methods were reportedly shown to be "highly sensitive, easily detecting miRNAs in patient sera." Importantly, the lab was able to identify miRNA signatures that correlate with patient risk of progression as defined by the commonly used metric, the Cancer or Prostate Risk Assessment Score (CAPRA).
Unlike many other studies, samples were taken from patients who had not yet received prior treatment; results, therefore, reflected biomarkers of disease risk at the stage when decisions regarding interventions must yet be made. Based on these findings, the Blelloch lab is extending its studies to additional patient populations with the aim of providing a new component to the risk metrics for prostate and other cancers.
The research team has a main focus on the functional roles of miRNAs in development and in disease. The Dgcr8 knockout tool is employed as a starting point for many of their studies. By initially removing all canonical miRNAs, study of individual miRNAs in isolation is facilitated. This approach has been successfully applied by the lab with embryonic stem cells, and in prostate cancer (with preliminary results obtained in a commonly used mouse model of the disease). Data showed that while miRNAs may not be required at the earliest stages of disease, they are essential for progression.
The Blelloch lab is now using the animal model to uncover relevant individual miRNAs and systematically dissecting downstream pathways regulated by those miRNAs. Such studies will provide a systems, or network, view of genes important in prostate cancer patients, including nodes that can then be used to direct small molecule development.
Fazlul H. Sarkar, Ph.D., professor of pathology at Karmanos Cancer Institute at Wayne State University, is profiling miRNA signatures associated with various cancers and other diseases and studying means of regulating miRNA activity by natural agents with known anticancer effects.
"We are looking at active compounds in dietary agents involved in either destroying miRNAs with oncogenic activity or augmenting the expression of miRNAs that are downregulated in diseases," Dr. Sarkar said. The complete mechanisms of activity have yet to be characterized, but he has hypothesized that demethylation of selective promoter sites is involved in reexpression of miRNAs that suppress oncogenesis.
His lab is also exploring cancer recurrence stemming from cells that have survived in patients through past treatment regimens. "Lab findings, including our own, have shown two distinct features of such cells, including one called epithelial-to-mesenchymal transition, or EMT.
"Most epithelial tumors are epithelial-cell tumors that are morphologically and genotypically epithelial; when cancer is survived through a therapeutic insult, such cells can change their phenotype and become mesenchymal," Dr. Sarkar explained, whereby they can opportunistically invade the vasculature to relocate to eventual metastatic sites within the body. Such cells also acquire cancer stem cell characteristics.
Dr. Sarkar's lab is exploring the miRNAs involved in cancer recurrence and their responses to such natural agents as indoles, isoflavones, and curcuminoids. The work is yet at proof-of-principle stage. Three Phase II trials of isoflavones in prostate and breast cancer showed positive results, with one study indicating a reduction in radiation-induced toxicity.
Previous Phase I trials in prostate cancer led to a Phase II study in patients with newly diagnosed cancer. A protocol has now been completed for a Phase II trial in patients with triple-negative breast cancer (negative for estrogen, progesterone, and Her2 receptors), offering an option for a disease clearly nonresponsive to conventional hormonal treatments.
Beyond the patient compliance that blood-test diagnostics permit, plasma-based diagnostic/prognostic assessments of miRNA avoid the problems of isolating from blood serum (whereby coagulation of proteins, with which miRNAs associate, can otherwise reduce yields and thus erroneously skew conclusions about miRNA levels in the samples). Ultimately, advances in miRNA R&D may open treatment options that drastically affect prognostic outcomes.
As proof of principle, Dr. Sarkar's laboratory has shown that the expression of specific miRNAs whose expression is lost in aggressive cancer cells (miR-200 and let7) can be upregulated by these natural agents, opening doors for novel cancer therapies.
"We and others have shown that the expression of miRNA can be prognostically related to patient survival. In pancreatic tumors, for instance, median survival can be as short as six to eight months, whereas certain patients exhibiting low expression of miR-21 have a median survival of approximately 43 months." Dr. Sarkar stated that the application of miRNA in cancer therapy is still in its infancy, and he predicted rapid progress going forward, to the benefit of patients.
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Duane Norman Thackeray
3/3/1925 – 12/19/2012
Duane Norman Thackeray was the world's nicest guy, according to his daughter, and everyone else for that matter. He was born in Sioux City, Iowa on March 3, 1925. He died on Dec. 19, 2012 in Carpinteria.
Duane moved to Los Angeles with his parents, Bill and Tillie, and his older brother Don. They drove out here from South Dakota in a Model A with another family, parents and two kids. Imagine that trip! Duane graduated from Fremont High School and went on to join the Navy during World War II. He spent two years in the South Pacific. He told about having the job to swim out to the seaplanes and bring the line in to anchor them. When he returned from WWII, he briefly went to Pepperdine College until he received the opportunity to become a Los Angeles City Firefighter. He was on the Department from 1947-1977. Most of that time was spent on Crash Crew at LAX.
Duane married Shirley May LaBeau in 1948. They had two children, Dennis Wayne and Diane Lynn. Even after their divorce he continued to be an integral part of his children's lives. As an avid body surfer and ocean lover, he bought both kids surfboards in 1962. They both continue to enjoy the sport to this day.
Duane married Nora Elizabeth Newsome in 1967. He became "Dad" to her three children, Jaque, DeEtta and Sandy, and "Grandpa" to their children. In 1978 Nora and Duane moved to Goldsboro, N.C., Nora's hometown. Here they joined the Good Shepard Lutheran Church where they made many friends and had lots of good times going places with the Recycled Teenagers and helping with the Annual Yard Sale. Unfortunately Nora passed away in 1998, and Dad had to carry on without the love of his life.
In 2007 Duane moved to Carpinteria to live with his daughter, Diane, and son-in-law Mike Hendrix. Here he joined Faith Lutheran Church and made many new friends. During this time he walked most every day through the State Park and went to Senior Lunch at the Veteran's Hall. He was happy!
Alas, his health took a turn for the worse. He spent the last two and a half months at Pacific View Senior Care Facility in Carpinteria where Cathy Miller and her crew took incredible care of him until he passed. Also, much appreciation to Visiting Nurse and Hospice Care, especially, Eva, who helped keep him so comfortable.
He is survived by his older brother, Donald Thackeray (Marguerite); children, Dennis Wayne Thackeray, Diane Lynn Thackeray (Michael Hendrix), Jaque Hickman (Art), DeEtta Mitts (Harry) and Sandy Purtle (Judith); grandchildren Wendy Mockett, Brent Anderson, Greg Jordan, Lisa Rice, William Purtle II, Casey Purtle, P.J. Purtle, Adam Purtle; great-grandchildren Dalton DeAlba, Sean Rice and Makenna Anderson.
A memorial service will be held on Thursday, Jan. 3, at 11 a.m. at the Faith Luthern Church, 1335 Vallecito Place, Carpinteria. A reception will be held at the church immediately following the service.
Contributions may be made to Faith Lutheran Church, Carpinteria or Good Shepard Lutheran Church, 532 Country Day Road, Goldsboro, N.C. 27530.
Arrangements entrusted to Welch-Ryce-Haider Funeral Chapels.