text:
Hoard's Dairyman: How are those heifers doing . . . really?
How are those heifers doing . . . really?
by A. F. Kertz
The author is the principal in Adhil, LLC, a St. Louis-based consulting firm.
Some measure of calf and heifer growth is useful since they are "grown" as herd replacements. But in practice, growth often is not measured. This may seem a bit academic, but it is a very practical issue.
If a commercial calf or heifer grower is paid on the basis of gain, then a few scale weights are taken in order to establish a starting point and ending point for payment. In larger operations, this measure may be by groups of calves, being sure that calves are identified which are in the group initially so that the same calves can be measured as a group at the end point, too. On a smaller scale and with individual calves, body weight can be estimated by a calibrated tape measure.
But what about height as a measure of growth? This can be done at the withers/shoulders or at the hips. It seems more people now use hip heights than wither heights, as they may be easier to take and are less variable because young stock tends to stand more calmly for hip height than for wither height measurements.
While height curves typically have been based on wither height, these curves can be approximated for hip height by simply adding 2 inches. There also is a reasonable relationship between body weight and wither height, heart girth, hip width, and body length with correlations in the high 0.90 range (1.0 being perfect). And then there is the relationship between heart girth and body weight which was established in 1935 by Missouri scientists with an accuracy of plus or minus 7 percent of actual heifer weights.
Another element not often recognized is the rate at which height growth occurs. With heifers 30 inches tall at birth and 54 inches tall at first calving, 50 percent of that 24-inch gain in height is realized in the first 6 months of life, another 25 percent in the next 6 months, and only 25 percent during the last 12 months before first calving.
But what if the genetics and size of cows is greater than the population used to develop these thumbrules? I know no reason that this relationship would not be proportionately the same. Also, if you have measured and tracked individual calves under 6 months of age at regular intervals, you will have noted at times that height and weight go through growth spurts, just as children often are observed to do. This is another reason that experimental or field numbers must have enough observations and measured frequently over time so that these variations will not prevent measuring true differences.
There are several factors which can impact growth measurements, some especially in calves under 2 to 3 months of age. Some of these are as follows:
• Level of intake. The gut residence time of milk or milk replacer for a young calf is relatively short. These feeds have a very high digestibility and relatively fast transit. Most milk or milk replacer feeding rates are between 1 to 2 percent of body weight. By contrast, starter intake at weaning may be 1 to 2 pounds daily which is about 1.5 percent of body weight. After weaning, when starter intakes should be 4 to 6 pounds daily, rumen fill will change noticeably as starter intake alone becomes approximately 3 percent of body weight on a dry matter basis. This in itself distorts true body weight gain. This also is why there should be several postweaning body weights taken to truly measure gain as apparent daily gains of about 3 pounds or more daily can be measured if you catch calves on the upswing of rumen fill.
• Intake and outgo. Calves drink water at about four times their dry matter from starter. Therefore, water consumption associated with starter intake before weaning may be 4 to 8 pounds daily (about one-half to a full gallon) which goes up to 16 to 24 pounds after weaning. Additionally, timing of urination and defecation contribute to body weight variation.
At this stage, body weight is around 150 to 200 pounds. This is a relatively low number when intake for water or starter, along with urination and defecation, are relatively large relative to this body weight. Hence, daily gains can be quite variable and high at this time which is why more frequent weighings and with more calves are desirable, especially for research purposes which is where we get our guidelines. This variation in body weight will drop off with age as heifers grow since feed and water intake drops relative to weight.
• Rumen roughage fill. Compared to calf starter, roughage/forage has a lower digestibility, slower rate of fermentation, and a longer residence time in the rumen. This affects rumen fill and can reduce dry matter intake. You should begin feeding roughage/forage after 2 months of age. This is another transition time, like the weaning transition time, which can result in skewed body weight gains. It also can result in gains which are not representative of true overall growth.
A classic study in the United Kingdom in the 1960s illustrated how distorting rumen fill from roughage can be. These calves were fed various levels of forage and weaned at 5 weeks and sacrificed at 12 weeks.
Clearly, as roughage feeding level went up, so did rumen and digestive tract contents as a percent of body weight. It varied from 26 percent of body weight with 16 percent forage up to 36 percent at 31 percent forage.
• Estimators of BW gain.A hipometer was compared in a University of Guelph study to more traditionally available tape weights in reference to scale weights. A total of 311 Holstein heifers were used from four Canadian research herds. They ranged from 1 week old to immediately prior to calving (24 months).
Mean body weight of all heifers was 575 pounds. Correlations between hipometer and scale weights and scale and tape weights were similar, particularly for heifers aged 3 to 15 months. Authors noted this was of particular concern because groups outside this range represent ages when dairy heifers would be weaned (less than 3 months) and when breeding would normally begin (older than 15 months).
Now what was missing in all of these factors in data just reviewed? If we are measuring true growth, there should be measures of height and maybe length and width, too. But until there is a relatively more simple method of doing this, such measures are not likely to happen.
Why is this important? Calf and heifer growth affects economics of your business whether you grow them or have them raised. Eventually, it affects the kind of cows that you have along with their milk production. What are you doing on your operation to measure calf and heifer growth?


text:
Former Parkland and Penn State football standout Austin Scott is facing nine felony drug charges.
Scott, 28, of 2118 W. Allen Street, Allentown, was arraigned by Lehigh County Magisterial District Judge Patricia Warmkessel Wednesday night, court paperwork shows.
According to the documents, he faces nine counts of felony drug charges for manufacturing, delivering or possession with the intent to manufacture or deliver.
He's also charged with criminal use of a communication facility.
The criminal complaint states that Scott sold marijuana to undercover officers on four separate occasions in July, September and October at various locations in South Whitehall Twp. and Allentown.
When police searched his home, they found marijuana, a scale and a pipe.
Scott was a 2003 graduate of Parkland and helped the team win a state title in 2002. He was heavily recruited and eventually played for Penn State.
Scott was charged in 2007 with raping a woman at his Penn State University apartment but the charges were later dropped.
In 2008 Scott was signed as an undrafted free agent with the Cleveland Browns but was released during the preseason.
In 2009, a lawsuit filed by Scott was dropped -- it claimed the rape allegations and subsequent arrest ruined his football career.
He was released on $10,000 bail. A preliminary hearing is set for Nov. 12.

subset: commoncrawl


text:
Subscribe to my blog here
Twitter me- I'm babysteph
February 2, 2009
American Idol 2025
Subscribe to my blog here
36 comments:
You and your husband's adoration for her is so beautiful and sweet.ReplyDelete
And you have a lovely voice too.
She is such a sweet little star in the making.
Oh that is too cute! I love the little baby songs and babbles; just so very sweet.ReplyDelete
that is so sweet... don't you just love this age!!!ReplyDelete
So cute!ReplyDelete
I've read that babies respond to music earlier than speech. They respond to tones and sounds.
Still that is adorable.
I can't believe this!!! I am so amazed and have never seen anything like this at such a young age. My grand-daughter is going to be a singer. You need to send this to the Ellen show or David Letterman. Can I tag along when she goes to try out for A.I.?ReplyDelete
Too cute! And the little hiccups are sweet too. :)ReplyDelete
So sweet :)ReplyDelete
My baby does not sing like that, he's more of a mover. I love that Ivy is responding to music like this. So sweet!ReplyDelete
Melody and harmony! Bring on Simon and crew!ReplyDelete
She is adorable :) What a cutie!ReplyDelete
Oh my goodness! There are so many cute things going on with that video!ReplyDelete
*her outfit is ADORABLE!
*her voice is SO precious!
* I love how she starts to suck her thumb in between "singing"
*it is so sweet how your husband says "you're a singer girl, you're going to be a singer girl" (precious!)
* and your "la, las" aren't bad either ;)
What did I tell you...so much cuteness going on!
Too sweet.ReplyDelete
Oh, isn't she sweet? And her little tongue sticking out is so cute.ReplyDelete
You have a beautiful voice too, you know.
And your husband's voice is so calming and gentle.
It's obvious that you both adore her.
Oh how cute is that!!! I love simply love it. Baby Sister loves music too.ReplyDelete
Oh I'd vote for her - how sweet! And you have a beautiful voice too. :)ReplyDelete
How sweet and I love the hiccups thrown in there, too!ReplyDelete
Too cute! I love the way you and your husband both gush over her. She's a lucky baby.ReplyDelete
Oh my goodness, she's a musical genius!!! Thanks a lot for getting me on the I-need-another-baby phase!ReplyDelete
Oh my, that is so very sweet. I love to hear her sing! Libby loves to sing also. Isn't it just so sweet?ReplyDelete
This is just such a perfect moment! You are so blessed, thanks for sharing the sweetness!ReplyDelete
That is too cute. You have a good voice, too.ReplyDelete
So very cute!ReplyDelete
That was so cute!! She was singing right along with you. Even between her hiccups. She is precious!ReplyDelete
argh! i love her! :)ReplyDelete
AW!!!!!!! That may just be the coolest/sweetest thing I've ever seen.ReplyDelete
Oh she is just adorable! So is that jacket, mind if I ask where you got it?ReplyDelete
Ohmygosh, cutest thing I've seen all day! She will get a lot of votes.ReplyDelete
What a beautiful little girl, I love how much you can just SEE that you love her, and how much she's brought to your lives. What a treasure.ReplyDelete
Oh my, she is so cute. I'm enjoying seeing Ivy grow, especially since I had my second daughter two weeks before she was born. They're at very similar stages. ;)ReplyDelete
I agree...she's gonna be a singing gal! Adorable!!!ReplyDelete
I'd spend the $1.95 or whatever it is to call her number on AI.ReplyDelete
Can you not just DIE from the girly noises!!?!?!ReplyDelete
Yeah, I think Simon is really going to like her! Especially her outfit! ; )ReplyDelete
LOL! She's singing, "I'd rather be nursing..." :)ReplyDelete
She is so sweet and you have a beautiful voice as well! My little Annika is 3 1/2 months old and she doesn't say much at all. (Unless she wants us to know something!) I think she's going to be kind of quiet and shy. I can't wait to hear her sing and babble!ReplyDelete


text:
Monday, January 14, 2013
The final minutes have ticked off the clock in 2012 and its time to look back at the year and relive some of the moments that made it one to remember or forget.
What follows is not a ranking but a look back at many of the individual sports stories and moments that were important to the Gazette-area readership.
Were sure there were some others that meant a great deal to you as well.
Goose Creek booted from playoffs
Goose Creeks football season came to a stunning and devastating conclusion in November.
First, the unbeaten Gators were made to forfeit their 48-7 playoff victory over Conway by the South Carolina High School League for using an ineligible player.
Then, they were reinstated by a circuit court judge on a Friday morning, enabling the Gators to defeat Bluffton 35-25 in a second round game later that night. But he also ruled the Gators had to reappear in front of the SCHSL Executive Committee two days later in an open meeting and they were removed from the playoffs again.
In 38 years of being associated with coaching football and athletics, Ive never seen such a total disregard, not only for the truth but, a lack of care or concern for kids, GCHS coach Chuck Reedy said. There was obviously no interest by this committee to get to the truth. They had their mind made up.
At the heart of Reedys comments was the harshness of the penalty and the widespread devastation it caused the Goose Creek community. A self-reporting team was given the same treatment as one who would knowingly cheat.
The issue began when Huskey discovered a problem on the players transcript while reviewing eligibility for basketball on Nov. 12. The transcript had been updated since the athletes eligibility review in August for football and showed four prior years of high school. The original transcript used in August showed just three years of high school and that the student-athlete last attended Berkeley High School in 2011-12, so he cleared the eligibility process at that time.
Reedy and Huskey notified the SCHSL within 90 minutes of finding the possible violation and were promptly booted from the playoffs, leading to the week-long saga that saw the Gators repeat title shot slip out of their grasp. The extra year on the transcript was from Woodmont High School in 2008-09.
At the time, he was at Generations group home in Simpsonville, a home for abused boys. He did receive credit for completing some freshman work at WHS but he never physically attended classes at WHS.
Lawyers for Goose Creek and the school district argued the student-athletes eight semesters of athletic eligibility should have begun in 2010 when he first attended high school at Berkeley.
Changes have to be made, Reedy said. I dont know that what they did to us helped anybody at all.
The player was a special needs student on a non-diploma track that played just 17 snaps out of nearly 1,600 during the Gators 13-0 season. He never entered a game Goose Creek wasnt winning by at least 41 points.
Tramel Terry is Mr. Football
Goose Creek football standout Tramel Terry capped a phenomenal day in early December by winning the states Mr. Football Award. He had signed with the University of Georgia less than 12 hours earlier.
He exemplifies everything that a student-athlete should be, Gators football coach Chuck Reedy said. He characterizes the three elements that Goose Creek football is built on. He is an excellent student, carrying a 3.3 GPA. He has great character, leadership qualities, treats everyone with respect and gives of his time and effort to make a difference in our school and community. He has worked very hard to become the best football player he could be.
The senior receiver/running back accounted for nearly 1,900 yards and 24 touchdowns this season and finished as the only four-year starter in Reedys 11 years at GCHS.
Terry was chosen for the award over Byrnes receiver Akia Booker, Conway quarterback Mykal Moody, Strom Thurmond running back Darius Hammond and T.L. Hanna linebacker Ben Boulware.
The award was first handed out in 1995.
Boys of Summer
It was another successful summer on the diamond for the local American Legion baseball team. The group of high school players from various area schools won the League 1 championship for the third year in a row and went on to finish third in the state tournament in July.
All but five players can return this summer, including ace pitcher and outfielder Zach Lavery.
Lavery was 6-0 on the mound with two saves, fashioning a 1.70 earned-run average and fanning 59 batters in 46-plus innings pitched. He also had a perfect fielding percentage from his spot in centerfield and batted .341. He had team highs with 16 stolen bases and 25 walks.
Fellow Citadel signee Zack Wimmer could also be back. He led the team with a .384 batting average and drove in a team-high 39 runs.
Leading hitter Michael Gonzalez, who played both infield and outfield, batted .381 this past summer and was second with 11 stolen bases.
He led the group moving on, along with pitcher/outfielder Daniel Huskey, who batted .293 with 22 RBIs and posted a 3-2 mark on the mound. Catcher Dalton Franke is finished too after batting .304 and fielding both catcher and first base positions well.
Stackley leads SC to Shrine Bowl win
In December, Stratford football coach Ray Stackley guided an underdog South Carolina squad to a 23-19 win over North Carolina in the 76th annual Shrine Bowl of the Carolinas, played at Wofford College.
Its a great honor to coach in this game and its great to win, Stackley said after the win. Its such a big challenge. Our staff did a great job since last spring when we started looking at this thing and those guys worked hard.
Goose Creek standouts Gerald Turner and Tramel Terry also represented the Sandlappers in the game. In a downer of a moment, Terry was injured on the opening kickoff and Turner had six tackles and an interception.
Stratfords cheerleading squad and offensive line coach Tony Smith were also part of the South Carolina side
Savage second team All-ACC
Former Stratford soccer standout and Clemson senior forward Austin Savage was named to the All-Atlantic Coast Conference mens soccer second team in November. Savage played in 18 matches this season, scored eight goals and dished out assists for 20 points. He had a hat trick against Gardner-Webb match as he scored three goals all in the first half on Oct. 16. He became the first Tiger to have 20 or more points in a single season since 2006. The eight goals were also the most scored by a Clemson player since the 2006 season.
Knights Ruggles inducted into soccer hall
Scott Ruggles coached the Stratford boys soccer team from its inception in 1983 to 2003, compiling a 245-135-8 career record. His teams qualified for the playoffs 15 times and he was the Berkeley County coach of the year eight times and the region coach of the year six times.
Welch an All-SEC Freshman
Former Goose Creek High School basketball standout and current USC Lady Gamecocks forward Aleighsa Welch was named to the Southeastern Conferences all-freshman team.
Welch played in 33 games and was South Carolinas top rebounder with 6.06 boards per game to go along with her average of 7.6 points per game, which was fourth on the squad.
She was 13th in the SEC in rebounding and second among league freshmen.
To start the 2012-13 season for the Lady Gamecocks, she was averaging 12.7 points and 9.5 rebounds through December 26.
Both Goose Creek girls basketball coach Tim Baldwin and Stratford football coach Ray Stackley hit milestones during their respective seasons in 2012.
Both won their 250th games.
Stackleys historic win came in September when the Knights defeated Fort Dorchester 28-21. Junior quarterback Jacob Park helped usher the Knights to the victory. He passed for nearly 270 yards and scampered for over 60, having a hand in three touchdowns.
Ive got to be honest, Stackley said. Something like this is not an individual accomplishment. Weve had a lot of great players and coaches come through here. Weve had great support from the community and the administrators. This is a school award and a team thing. Its not just about me.
Baldwins victory came in December, with the Lady Gators rolling past Berkeley 66-22 at GCHS. Center Semoine Frasier and guard Alex Ludwig had 14 and 11 points respectively to lead the way for the Lady Gators.
This is not a me achievement, said Baldwin, in his 12th season in charge. This is a we achievement. It doesnt matter how good a coach is, youve got to have the players that want to get better and be the best they can be.
Gators play Cane Bay on ESPNU
The national spotlight shined on the Goose Creek Gators football team in October when they were televised nationally by ESPNU.
Their victim for the showing was Cane Bay.
The nationally-ranked Gators made it look easy against the outmanned Cobras, racing to a 21-0 lead after a quarter en route to their 21st straight victory. Tramel Terry and Caleb Kinlaw each scored three touchdowns for the Gators.
Kinlaw had 186 yards rushing on 14 carries, while Terry had 151 all-purpose yards.
Lady Gators advance to semifinal
This Goose Creek girls basketball team carried on the Lady Gators winning tradition but wasnt able to get as far as it had hoped.
Coach Tim Baldwins team lost in the Lower State final, 51-43, on Friday to Orangeburg-Wilkinson, ending the year in tears at the Florence Civic Center in late February. The Lady Gators were denied a third straight trip to the final in Columbia.
They played with great effort, a lot of determination and pride in who they are and what they represent, Baldwin said. It takes a lot of hard work and sacrifice to, one, build a program and, two, to keep it going.
The Lady Gators finished 24-5.
The loss was the final moment in a Lady Gators uniform for North Carolina signee Ndea Bryant (10.9 PPG, 7.9 RPG, 3.6 SPG), Brittani Doctor (9.3 PPG), Mikayla Tanner (5.2 PPG), Brendysha Liner (7.3 PPG, 4.7 RPG) and Nicole Taylor.
Gators first-ever season sweep of Stratford in baseball
Goose Creeks baseball team has long been a distant second to city rival Stratford in the annual series but in April the Gators completed a season sweep of the Knights. It was the first time ever.
Obviously, its huge, Gators baseball coach Scott Durham said.
Durhams team no-hit Stratford 5-0 on March 19 then won again 8-4 on March 31.
The Gators came back from a four-run deficit to double up the Knights in the second game, played at GCHS.
Chris Singletons solo blast in the fourth inning tied it 4-4 before Cody Smiths two-run triple gave the Gators the lead for good.
Tyler Rio followed with an RBI double for a 7-4 lead.
Zach Lavery scored on an error in the sixth inning for Goose Creeks final run.
Smith was the winning pitcher for the Gators, going four innings and allowing five hits, two runs and three walks. He struck out three batters.
Rio threw the final three innings to earn a save and worked around four walks by striking out four batters.
Hanahan wrestling repeat
The Hawks wrestling team swooped in on their second straight Class AA state championship in February, capping a season of growth with a 40-34 win over Emerald at Dreher High School.
We had the best program, said Hanahan coach Ray Adkins, whose team finished 21-7. The best program won the state championship this year. We graduated seven guys after last year and another didnt come back because of an injury.
Thats the type of program were trying to have around here, one that reloads not rebuilds.
Bryce Ellis, Dennis Flores, Jacob Garibay, Kevin Murray and J.J. Johnson all recorded pins for the Hawks, while Brett Maddox had a major decision victory.
Flores and Johnson later won individual state titles for the Hawks.
Coaching Carousel
As usual, some coaches moved out and others moved in 2012. At Goose Creek High School, the Blake Hall era began in boys basketball. Hall led North Charleston to the Class AA crown last winter and had the Gators off to an 8-1 start heading into the Roundball Classic on Dec. 27.
Also in 2012, Ira Owens took over the Cane Bay girls basketball team, Katrina Moffett took over the Hanahan softball program and Laurie Henderson became coach of the Hanahan girls basketball team.
Track Stars
Cane Bays Ashlee Eady and Hanahans Chris Brown captured individual state titles at the state track and field meet in May.
Eady won the high jump in Class AAA and Brown was the triple jump champ in Class AA.
Brown is now a freshman football player for Notre Dame, which takes on Alabama in the BCS National Championship football game on Jan. 7.
Never Ever Give Up
Various teams at all local high schools donned pink at some time during 2012 in the ongoing battle with cancer.
© 2016 The Gazette an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
|High-Pressure MOF Research Yields Structural Insights
|Wednesday, 26 February 2014 00:00
Metal-organic frameworks (MOFs) are a remarkable class of relatively new materials that exist as a subclass of a larger group called coordination networks. MOFs have shown promise in a variety of applications ranging from gas storage to ion exchange. The materials are comprised of organic linkers that bridge discrete metal building units. Accurate structural knowledge is key to the understanding of the applicability of these materials, and thus the use of single-crystal x-ray diffraction is invaluable in this field of research. As research has identified potential industrial viability for these materials, there has risen a need to better understand their mechanical and physical properties. To study some of these mechanical properties, researchers used ALS Beamline 11.3.1 to perform in situ, high-pressure, single-crystal x-ray diffraction. This experimental setup allows researchers to study how compounds rearrange and react to variable hydrostatic pressure loadings, as well as to measure mechanical properties such as bulk modulus.
The application of high pressure to a compound is important, as it provides information on phase changes or major structural shifts that could produce materials not currently obtainable through conventional means. It also allows us to understand how materials respond to external stress to provide information on their use in mechanical applications. If we can gain an understanding of how flexible frameworks react to high pressures, we can determine new applications for them that other, more rigid compounds may be incapable of surviving. One major benefit from this will be to study the structure property relationships and any anisotropy associated with these structure changes. A whole new family of piezofunctional materials may arise from the study of MOFs under pressure.
The sample chosen is an alkyl-chain supported MOF—Zn(HO3PC4H8PO3H)·2H2O. It has been named Zinc Alkyl Gate 4, or ZAG-4, for convenience. The compound was originally synthesized in 2003; however, no further work had been pursued. Researchers at Texas A&M stumbled upon the structure and noticed that when viewed down the c-axis it looked like a child safety gate. They had the idea to apply pressure to the compound in an attempt to open the gate.
By applying up to 9.9 GPa of external applied pressure in increments increasing from ambient pressure, researchers were able to study the structural deformation of ZAG-4. Single-crystal x-ray diffraction allowed for the solution of the crystalline structure at each pressure point as well as monitoring how the unit cell parameters were affected. Over the range of 7.32 GPa applied pressure, the unit cell volume decreases over 27 percent; however, after applying 9.9 GPa and then releasing the pressure and removing the sample, the unit cell parameters revert back to the original values from before the experiment, proving the structural resilience of ZAG-4. Included in the structural changes up to 7.32 GPa were some interesting characteristics: the b-axis of the system exhibits both positive and negative linear compressibility. Negative linear compressibility is the phenomena shown when a sample expands in one or more dimensions when external pressure is applied. What is truly interesting about ZAG-4 is that the compressibility of the b-axis changes, where the axis initially decreases then increases and then remains relatively stagnant. The structural changes associated with this correspond to a deformation and repositioning of the included water molecule in the channels that run along the c-axis. In addition to this, the inorganic chain-links begin to deform in a manner that causes them to compress in one direction and expand in the other.
The overall structural results from this experiment have shown that the alkyl-chains act as a spring-like cushion while allowing the inorganic portion to deform. This notion, given the correct design, may allow for researchers to develop new piezofunctional materials by incorporating metal ions that contain unpaired electrons to induce piezomagnetic moments among many other possible properties. This opens the door for MOF materials to find roles in a variety of applications such as pressure sensors, switches, and more.
Research conducted by: K. Gagnon (Lawrence Berkeley Lab), C. Beavers (Lawrence Berkeley Lab), and A. Clearfield (Texas A&M University).
Research funding: National Science Foundation, Texas A&M University Division of Graduate Education and Division of Materials Research. Operation of the ALS is supported by U.S. Department of Energy (DOE), Office of Basic Energy Sciences (BES).
Publication about this research: K. J. Gagnon, C. M. Beavers, and A. Clearfield "MOFs Under Pressure: The Reversible Compression of a Single Crystal," J. Am. Chem. Soc. 135, 1252-1255 (2013).
ALS Science Highlight #284


text:
HERSHEY - Next month, a group of local cheerleaders will leave their high school football fields behind to perform at Hersheypark Stadium.
Mifflin County High School cheerleaders Kiersten Capouillez, Madalyn Clouser, Ashley Wert and Juniata High School cheerleader McKenna Cleck have been chosen to perform at the 56th Big 33 Football Classic Game. Kickoff is scheduled for 7:06 p.m. June 15 at the stadium.
MCHS coach Collette Bender said cheerleaders were nominated by their coaches and participated in tryouts before being selected to perform at the game. To qualify, she said, athletes must be high school seniors currently cheering for their school's football team and maintain grades higher than a C.
Article Photos
Sentinel photos by BUFFIE BOYER
Cheerleaders from Mifflin and Juniata counites will cheer at the Big 33 game in June. They are, from left, Mifflin County High School's Kiersten Capouillez, Ashley Wert and Madalyn Clouser.
Sentinel photos by BUFFIE BOYER
Cheerleaders from Mifflin and Juniata counites will cheer at the Big 33 game in June. Shown here is Juniata High School's McKenna Cleck.
"(Judges) prefer (cheerleaders) to be well rounded," said Angela Clark, JHS cheerleading coach.
The same holds true on the field. Both coaches agreed that cheerleaders with the most diverse set of abilities have a greater chance of being selected for the team.
"It's the best cheerleaders in the whole state of Pennsylvania," who are chosen, Cleck said.
At tryouts, cheerleaders had to learn and perform a fast-paced routine that challenged them to dance, stunt and jump to the best of their ability.
Clouser said participants didn't know the dance ahead of time and had to memorize the moves in about an hour. Though the girls agreed they left tryouts unsure of their performances, Clouser said she was "just happy I got the chance to do it."
When the girls received word that they were accepted onto the team, they were even happier.
"I was real excited, I was jumping around my house!" Cleck said.
For Wert, the chance to cheer at the Big 33 game has been years in the making.
"Before the schools merged, I had friends who participated in Big 33 ... I heard so much about it," she said, adding that making the team has been a long-term goal.
Cleck said she has been a flyer and a base on cheerleading teams in the past and will maintain her position as base on the Maryland team at the game. The MCHS cheerleaders will join her on the Maryland team, but have not received their positions yet.
Bender said the cheerleaders have to be prepared to perform in any position on the field since judges seek athletes who have "everything in one package" during tryouts.
Wert said she especially enjoys tumbling and basing really hard stunts - maneuvers that she says make her "feel powerful."
"(The cheerleaders) are willing to do whatever you ask of them," Bender said. "They're go-getters ... not ones that are going to sit back."
Also during the game, cheerleaders will participate in the Big 33 Buddy Program, which partners special needs children with Big 33 athletes. Capouillez said spending time with her buddy is the thing she is looking forward to most about the experience.
"I enjoy being the person that can cheer people up and encourage them ... give them something they don't always get to do," she said.
Capouillez said cheerleaders meet with their buddies on Thursday and Friday during the week of the game to learn cheers, design T-shirts and hang out together.
Kiersten Clark, eighth grade student in the Juniata County School District, will also attend the Big 33 game as a volunteer for the Buddy Program. Clark said she has been an all star cheerleader for seven years and will cheer at JHS in the fall.
During practices, Clark will help teach the buddies cheers and their halftime performance.
"I love seeing their smiling faces," she said. "Not only do they look up to the cheerleaders, they look up to us."
Angela Clark said there is nothing better than game day when the athletes and buddies come together.
"You don't have to tell (the buddies) to get excited ... they're never tired!" she said. "I think it's inspiring for the cheerleaders, too."
After the game, three of the girls plan to pursue cheerleading outside of high school. Clouser said she will take a year off to work and continue cheering with her all star team, then plans to attend Indiana University of Pennsylvania to become a physician assistant. She added that she plans to join the National Guard during college.
Wert said she will take a temporary leave from cheerleading to attend Penn State University, majoring in film and video. However, she would like to own an all star gym or coach high school cheerleading in the future, she said.
Cleck plans to attend Penn State Altoona and try out for the cheerleading squad there.
When the Big 33 game is over, Capouillez said she will hang up her pom pons to study actuarial science at Lebanon Valley College.
But for now, the cheerleaders look forward to one last "hurrah" before the next chapter begins.
"Not everyone has the chance to show everyone how good they are," Clouser said, adding that the Big 33 game is a chance to "show everybody what we can do."


text:
Felco 6" Folding Saw
This item is currently not available.
Additional Information
Felco 6" Folding Saw
- Super-sharp saw easily cuts through all types of wood
- Rust-resistant, hard-chromed blade makes clean cuts that heal quickly
- Ergonomic, soft-grip handle for comfort during use
- Folds for safe storage
The name Felco stands for quality tools and this saw is no exception. The super-sharp hard-chromed blade makes clean cuts that help plants heal faster. The soft-grip handle reduces stress on hands and wrists. Unique blade design minimizes binding; blade locks in place when cutting to prevent accidental closure. Folds for easy and safe carrying and storage.
Product Details
- Hard-chromed blade
- 14" L overall; folds to a compact 8" L
- Cuts on the pull stroke
There are no special shipping restrictions or charges associated with this item. For detailed information about our delivery methods and charges, click here.
We're proud of the fact that this item is shipped to you directly from our warehouse in Vermont, by one of our 250 employee-owners. In-stock items are packed with care and shipped within the next business day to ensure prompt delivery to your home and garden!


text:
What Is Bronchitis?
What Is Bronchitis?
Bronchitis occurs when the bronchial tubes (airways in the lungs) are irritated by a virus, bacteria, or allergen. This causes a cough that produces yellow or greenish mucus. The cough can be acute (short-term) or chronic (long-lasting or recurring). Smoking or exposure to secondhand smoke is the most common cause of chronic bronchitis.
Inside Healthy Lungs
Air travels in and out of the lungs through the airways. The linings of these airways produce mucus. This mucus traps particles that enter the lungs. Tiny structures called cilia then sweep the particles out of the airways.
Healthy Airway: Airways are normally open. Air moves in and out easily.
Healthy Cilia: Tiny, hairlike cilia sweep mucus and particles up and out of the airways.
A Nasty Cough
Bronchitis often occurs when a cold or flu virus infects the airways. Once infected, airways become inflamed (red and swollen). Excess mucus forms, triggering a deep "hacking" cough. A second infection, this time due to bacteria, may then occur. Airways irritated by allergens or smoke are more prone to infection.
Inflamed Airway: Inflammation and excess mucus narrow the airway, causing shortness of breath.
Impaired Cilia: Excess mucus impairs cilia, causing congestion and wheezing. Smoking can paralyze cilia, worsening the problem.
Making a Diagnosis
A physical exam, medical history, and certain tests help your healthcare provider learn what may be causing the cough. This information is used to plan treatment.
Health History
Your healthcare provider may ask about:
How long the cough has lasted, and how long it's been producing mucus.
Other symptoms, such as a runny nose, sore throat, or fever.
Medications you've used to treat symptoms.
Whether the problem has occurred before, when, and how often.
Smoking or exposure to secondhand smoke.
Lung conditions such as asthma or COPD (chronic obstructive pulmonary disease).
Factors that increase the risk of complications, such as age and certain health problems.
The Exam
During the exam, your health care provider listens to the chest for signs of congestion. He or she may also check the ears, nose, and throat.
Possible Tests
A sputum test for bacteria. This requires a sample of mucus from the lungs.
A nasal or throat swab for bacterial infection.
A chest X-ray if your health care provider suspects pneumonia.
Tests to check for an underlying condition, such as allergies, asthma, or COPD. You may be referred to a specialist for further lung function testing.
Treating a Cough
The main treatment for bronchitis is easing symptoms. Avoiding smoke, allergens, and other things that trigger coughing can often help. If the infection is bacterial, antibiotics may be used. During the illness, limit activity and get plenty of sleep. To ease symptoms:
Don't smoke, and avoid secondhand smoke.
Use a humidifier, or breathe in steam from a hot shower. This may help loosen mucus.
Drink fluids. They can soothe the throat and may help thin mucus.
Sit up or lie with your head and shoulders propped on pillows to relieve congestion.
Ask your health care provider whether to use cough medicine, pain and fever medication, or a decongestant.
If Antibiotics Are Prescribed
Is the problem a bacterial infection? If so, antibiotics may kill the bacteria, speed healing ,and prevent further complications. But most cases of bronchitis are caused by cold or flu viruses. Antibiotics don't treat viral illness. Taking antibiotics when they are not needed increases your risk of getting an infection later that is antibiotic-resistant. Your health care provider will prescribe antibiotics if he or she thinks they are likely to help. If they are prescribed:
Take the medication until it is used up, even if symptoms have improved. If you don't, the bronchitis may come back.
Take them as directed. For instance, some medications should be taken with food.
Ask your health care provider or pharmacist what side effects are common, and what to do about them.
A follow-up exam is advised in 2–3 weeks. By this time, symptoms should have improved. An infection that lasts longer may signal a more serious problem.
To Prevent Future Infections
Avoid tobacco smoke. If you smoke, quit. Stay away from smoky places. Ask friends and family not to smoke around you, or in your home or car.
Make sure that any allergies are identified and treated.
Ask your health care provider about getting a yearly flu shot.
Wash hands often. This helps reduce the chance of picking up viruses that cause colds and flu.
Call Your Health Care Provider If:


text:
On Saturday, November 5, 2011, nearly 1,200 guests gathered at the Wilshire Ebell Theatre in Los Angeles for the IMF's 5th Annual Comedy Celebration benefiting the Peter Boyle Memorial Fund, which supports the IMF's award winning research program and patient services.
Hosted by Ray Romano, the show featured appearances from fellow Everybody Loves Raymond castmates Doris Roberts and Fred Willard. In addition, this year's show benefited from the talents of Tom Arnold, Darrell Hammond, Dom Irrera, Colin Quinn, and a special musical performance by Peter Gallagher.
Click on the PDF tab above to view the document.


text:
|Structures for Three Membrane Transport Proteins Yield Functional Insights
Cells depend on contact with their outside environment in order to thrive. Two examples illustrate why: In one, information needed to guide cellular processes is constantly transmitted across cell membranes by specialized proteins, and in the other, maintaining the right gradient of ions across the membrane is a process critical to the life and death of a cell. Membrane transport proteins—functioning either as channels or transporters—are the gatekeepers that control contact with the world outside the cell by catalyzing the flow of ions and molecules across cell membranes. Malfunctioning transport proteins can lead to cancer, inflammatory, and neurological diseases. Despite their importance in cell function and in a multitude of physiological processes such as sensing pain, there are still many unknowns about how they function. Recently, in an impressive series of three papers in Nature and Science, researchers at the Oregon Health and Science University delineated the structures of three transporter proteins, one of which had never before been characterized structurally in such detail. The structures were solved using ALS Beamlines 5.0.2, 8.2.1, and 8.2.2.
Two of the protein structures solved were ion channels: the P2X receptor, which is ATP activated, and an acid-sensing ion channel (ASIC). The researchers had predicted that these two proteins would have different topologies, but were surprised to discover that the proteins showed remarkable similarity in their structures, despite large differences in their function and in their amino acid sequences. They are both trimers, each consisting of three protein strands that angle sharply through the membrane and wrap slightly around one another, creating a chalice-like structure. Both contain "vestibules" outside the membrane, where ions might be directed and might serve a regulatory role, as well as a central pore that opens and closes as necessary to allow ions to traverse the membrane.
The structure of the P2X receptor revealed grooves, located on sections of the protein outside the membrane, that most likely serve as ATP binding sites. These binding sites were unique, representing an entirely new ATP binding motif. The structure also suggested a way in which ATP binding leads to the large structural changes involved in opening the central pore: the ATP binding site is lined with a series of amino acids that face the groove, as well as several that face away, allowing information to be transmitted from the binding site to the rest of the structure. The ASIC structure, in contrast, is proton-activated and allows only sodium ions in or out of the cell. By soaking cesium ions into crystals of this protein and solving the x-ray structure with the cesium bound in several places, the scientists were able to pinpoint specific ion-binding sites within the vestibules and central pore, suggesting the path that ions might take through the pore.
The third structure was an amino-acid transporter with a very different architecture. This type of transporter is involved in diverse physiological processes from blood-pressure regulation to digestion and neurotransmission. In contrast to the ion-channel structures, this protein is located almost entirely within the membrane, without the extracellular vestibules available for ion localization. Twelve helices span the membrane in a cylindrical structure that is organized to allow a solvent-accessible channel to penetrate deep within the transporter. The scientists used the structure to suggest a way in which proton binding to a specific amino acid changes the conformation of one of the helices and opens the channel, allowing a direct path from outside to inside the cell. This mechanism for transport is very similar to sodium-coupled transporters, showing how the structural mechanism for transport can be conserved among different types of proteins.
Research conducted by T. Kawate, E.B. Gonzales, J.C. Michel, W.B. Birdsong, P.L. Shaffer, A. Goehring, and A. Shankaranarayanan (Vollem Institute, Oregon Health and Science University) and E. Gouaux (Vollum Institute, Howard Hughes Medical Institute, and Oregon Health and Science University).
Research funding: National Institutes of Health, New York Consortium for Membrane Protein Structure, National Asthma Foundation, and Howard Hughes Medical Institute. Operation of the ALS is supported by the U.S. Department of Energy, Office of Basic Energy Sciences.
Publications about this research: T. Kawate, J.C. Michel, W.T. Birdsong, and E. Gouaux, "Crystal structure of the ATP-gated P2X4 ion channel in the closed state," Nature 460, 592 (2009); E.B. Gonzales, T. Kawate, and E. Gouaux, "Pore architecture and ion sites in acid-sensing ion channels and P2X receptors," Nature 460, 599 (2009); P.L. Shaffer, A.Goehring, A. Shankaranarayanan, and E. Gouaux, "Structure and mechanism of a Na+-independent amino acid transporter," Science 325, 1010 (2009).


text:
Champion Red and White is crowned
Submitted by World Dairy Expo on Fri, 10/01/2010 - 15:01
Hoard's Dairyman:
Champion Red and White is crowned
Date:Fri, 10/01/2010
Blondin Redman Seisme is the new queen Red and White. She was named Grand Champion Red and White earlier today at the Grand International Red and White show at World Dairy Expo. She is owned by Morsan Farms, Ltd. of Ponoka, Alberta, Canada. Coming in Reserve is Silvermine Adv Tally-Red-ET exhibited by Milksource Genetics of Kaukauna, Wis. And joining the royal court is Honorable Mention Grand Champion Jon-Lu Talent Regina-Red-ET shown by Chillawack Cattle Company, Chillawack, British Columbia, Canada.
Judge Brian Carscadden is shown at far right with his royal court of Red and Whites. Grand is shown next to Judge Carscadden, foll0wed by Reserve and Honorable Mention.


text:
Share < br />this article:
Jessica Alba Grabs Starbucks With Honor in Brentwood
Amanda Hasaka
| January 6, 2012 - 6:29 pm
Share < br />this article:
View Full Size
Return to Story
Celebrity Kids
Jessica Alba
Recommended for you
Jessica Alba's Honest Co. Reportedly Could Soon Be Sold for More Than $1 Billion
WATCH: Jessica Alba Gives Stephen Colbert a Hipster Millennial Makeover
Jessica Alba On Her Laid Back Approach to Fitness
Ashton Kutcher on Keeping His Daughter Out of the Spotlight: 'It Is My Job'
Adam Brody on His Morning Routine with His Daughter: 'We Hike Around Our House'
Jessica Alba Admits She Regrets Her Tattoos: 'I'm Not Into Them Now'
Around The Web
Elle Macpherson Regrets Her 'Friends' Role
Taraji P. Henson Drags 50 Cent Over 'Empire' Diss
WATCH: Katy Perry Tries (and Fails) to Vote Completely Naked
Mary-Kate and Ashley Olsen Relax Poolside in France
Rob Kardashian Tweeted Out Kylie Jenner's Number in the Midst of…
Sign Up For The Latest Celebuzz News
Thank you for signing up for our newsletter. You will receive a confirmation shortly.
Sign Up
Top Photos
All »
Ariel Winter Showing Major Skin Leads Today's Star Sightings
Amber Rose Is About to Become $8 Million Richer
Lindsay Lohan Brings Gifts to Syrian Refugees in Turkey
Hilary Duff Gushes About Boyfriend Jason Walsh: 'He's a Great Guy'
Kaley Cuoco's Body Is Inspiring Us to Take Leg Day at the Gym More Seriously
Emily Blunt Calls John Krasinski Her 'Perfect Man'
You'll Love
Emily Blunt Gushes About Her Husband
Seth Meyers Recaps Presidential Debate
'Grey's Anatomy' Season 13 Spoilers


text:
The Dremel Trio allows users to cut, sand and rout using one multi-purpose tool. Cut multiple materials including wood, plastic, drywall, sheet metal, wall tile and more without switching tools. The tool's unique, 360-degree cutting technology and plunge-cut ability allows users to make quick and controlled cuts, while its unique, 90-degree pivoting handle facilitates added control, comfort and accuracy.
This tool is available as part of a kit.


text:
The new proposal is just another way for the dwarf to say screw you. Does this moron really believe Fehr would stupid enough to not see the rollback?
I am starting to think some owners gave out these huge contracts expecting the players to take less again.
They won't roll over this time Europe would be more than happy to welcome them back. We need a new commiSsioner asap.
Owners should be embarassed by this offer.
Sent from my BlackBerry
That's the thing. Bettman and the league keep saying how only 12 teams are profitable.
Are the Devils and their ridiculous contract for Kovalchuk profitable?
Are the Wild with the two giant contracts they just took on in Suter and Parise?
Or the Preds when they gave Weber $110 million over 14 years?
Or the Hurricanes who gave Semin a $7 million deal?
The owners are doing this to themselves and each other, yet expect the players to bear most of the burden for fixing their idiocy.
Reduce the players share by a few percentage points (keep in mind owners are reducing what constitutes HRR so even if the percentage were the same, the owners are getting more money). Put a reasonable limit on contract length of 7 or 8 years to make it harder for GM's to circumvent the cap like they have been. Increase revenue sharing if the owners really do want to help these struggling franchises. Minor tweaks to most other things. Play hockey.


text:
TAHOE, Calif. — Navigating your kayak by moonlight is a mystical experience you won't soon forget. California State Parks and West Shore Sports team up for this opportunity at Ed Z'berg-Sugar Pine Point State Park on Thursday, Aug. 2. Experience-the magic of Lake Tahoe at dusk while learning about the area's unique history. The atmosphere is peaceful and calming, yet spectacular. Paddle leisurely while admiring the moon's silvery light reflecting off the water's surface. Bring your friends and family.
No experience is necessary and this activity is suitable for all ages. The tour is $25 per person and includes park entrance, kayak rental, life vests and instruction. Wear synthetic clothing rather than cotton (swimsuit, shirt, shorts, lightweight pants, jacket and warm cap). Bring water, retainer strap for glasses and water shoes. Proceeds benefit the Sierra State Parks Foundation. Meet at the North Boathouse on the Day Use side of the park at 7:30 p.m. for the two-hour adventure. Reservations are required at 530-525-9920 and space is limited.


text:
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
NSCLC is "Major Battlefield" as Merck,...
As Immunotherapy Revolutionizes the Cancer Treatment...
If there is one thing that researchers agree on, it's that now is a good time to be working with RNA interference (RNAi). RNAi is a natural cellular mechanism that regulates gene expression at the stage of translation by degrading the mRNA or blocking translation. It can also alter the level of transcription of specific genes.
Double-stranded RNA (dsRNA) triggers a series of biochemical events that culminates in sequence-specific suppression of gene expression. "Long dsRNAs have been employed for many years as a means to modulate gene expression in plants, yeast, and C. elegans," noted Mark Behlke, M.D., Ph.D., svp of molecular genetics and CSO at Integrated DNA Technologies (IDT; www.idtdna.com).
"Similar attempts in higher organisms failed due to interferon activation, however we now know that short RNA duplexes can be safely used in mammalian systems both in vitro and in vivo. The technology has rapidly matured, thanks in large part to all that was learned over the past 20 years using antisense oligonucleotides. RNAi is now routinely employed in vivo as an experimental tool and numerous groups are vigorously pursing the use of RNAi compounds as therapeutics. Several siRNA drugs are already in clinical trials and more are in preclinical development."
The RNAi pathway is initiated by the enzyme dicer, which cleaves long dsRNA molecules into short fragments of 20–25 base pairs. One of the two strands of each fragment, known as the guide strand, is then incorporated into the RNA-induced silencing complex (RISC) and paired with complementary sequences.
The most well-studied outcome of this recognition event is post-transcriptional gene silencing. This occurs when the guide strand specifically pairs with an mRNA molecule and induces the degradation by argonaute, the catalytic component of the RISC complex. Another outcome is epigenetic changes to a gene—histone modification and DNA methylation—affecting the degree to which the gene is transcribed.
RNAi targets include RNA from viruses. These targets also play a role in regulating development and genome maintenance. Breakthroughs in this technology are making it possible to access biological information that was not possible until recently.
The selective and robust effect of RNAi on gene expression makes it a valuable research tool, both in cell culture and in living organisms, because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. RNAi may also be used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine.
Discussion of these new technologies took center stage at the "Second Annual RNAi World Congress" in Boston last month, where presenters described some of the new opportunities that lay ahead for research and drug discovery. "This is a really exciting time to be in the field," said Dr. Behlke.
Design and effective delivery of synthetic RNAi compounds are essential for therapeutic applications, explained Dmitry Samarsky, Ph.D., vp of technology development for RXi Pharmaceuticals (www.rxipharma.com), whose offerings include rxRNA compounds. "rxRNA is a next-generation product that can be up to 100 times more potent than conventional siRNAs."
"The shortcoming with original unmodified siRNA is nuclease instability. The modifications we have made demonstrate nuclease resistance and are potentially more specific for their intended target. The other thing is that we can use compounds in the modification to block interferon. These three pieces are the foundation to this technology."
RXi's founding scientists recognized early that the key to therapeutic success with RNAi lies in delivering intact RNAi compounds to the target tissue and the interior of the target cells, noted Tod Woolf, Ph.D., CEO. "RXi will work with chemically synthesized RNAi compounds that are optimized for stability and efficacy. We intend to rely on a combination of delivery at the site of action and formulation with delivery agents to achieve optimal delivery to specific target tissues."
Dr. Samarsky also discussed RXi's nanotransporters, which have been used to deliver RNAi compounds to the mouse liver and obtain exceptionally low dose (1 mg/kg) gene-specific inhibition, the company reported. Delivery to the liver is critical for many metabolic targets, including diabetes and obesity. In addition, nanotransporters are of a defined size and are readily formulated.
"Topigen is focused on applying RNA approaches to respiratory diseases and finding innovative approaches to the discovery of new and better treatments for these diseases," said Nicolay Ferrari, Ph.D., director of pharmacology at Topigen Pharmaceuticals (www.topigen.com).
The company's focus is on therapy for inflammatory respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. Its core technology is based on a proprietary chemistry and a multitarget approach using antisense oligonucleotides. The company's products are designed to be inhaled to act locally and directly on lung tissue and thereby increase potency while reducing potential side effects by minimizing systemic exposure.
Topigen's technical strategy is to downregulate multiple and overlapping pathways in inflammation. The effectiveness of this approach, which circumvents the redundant nature of the human asthma/allergy inflammation response, has been proven in human trials of Topigen's lead compound TPI ASM8 for asthma, according to the company. In the case of COPD, Topigen's new antisense-based therapeutic, TPI 1100, targets two isoforms of the phosphodiesterase enzyme (PDE4 and PDE7) and is being developed to reduce lung inflammation and halt the progression of disease.
Dr. Ferrari focused on the company's RNA-targeting technology and the use of its 2´-deoxy-2´-fluroarabinucleic acid (FANA™)-platform, which originated from McGill University and was licensed exclusively to Topigen, said Dr. Ferrari. "It's a chemical modification of natural DNA. What differentiates FANA from other chemical modifications is that it promotes RNaseH activity," he added, "which is important for optimal efficacy of an antisense-based therapeutic."
Natural DNA is labile and not very resistant. The initial goal of chemical modification is to increase stability as well as the activity of the oligonucleotide. "By increasing potency and stability, we can reduce the dose—it's true that more is not necessarily better in dose ranging," explained Dr. Ferrari.
"The key advantage of FANA is the flexibility it allows us when designing oligonucleotides to increase potency and duration of action. When combined with our delivery by inhalation, it limits systemic exposure, which is essential in limiting side effects associated with systemic delivery of oligonucleotides." FANA represents a new chemistry that can improve properties of RNA-targeting agents including antisense, siRNA, and aptamers, Dr. Ferrari concluded.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
- Morning Baby and Me
Wednesday, October 1, 2014 | 11:00 am - 11:45 am
Stories, rhymes, and songs get you and your baby laughing and learning. Birth-age 2
No Registration Required
Older siblings may not attend.
MCPL Children's Services
Contact Number:
(812) 349-3100
Mary Frasier
- Event Type:
Main Library Children's Program
- Location:
Children's Program Room
Notify me about similar events


text:
Duobox Pen Case - Chalkdust Print
Item# AC3792
$39.00 $24.99
Detailshttp://www.kipling-usa.com/duobox-pen-case/100132174.html Duobox Pen Case Chalkdust Print
Item# AC3792
$39.00 $24.99
Select a Color
Product Actions
With two spacious fold out compartments, this trendy chic case offers maximum storage that's perfect for storing cosmetics, pens or any other small essentials you may need! Now featured in our fun new seasonal prints! Dimensions: 8.5" x 2.8" x 3" inRead More
- Full zip-around closure
- Main compartment contains 14 pen sleeves
- Small furry Kipling monkey key ring
- Imported
Ground Shipping Delivery: $8*
5-7 business days (if ordered by 12pm EST)
2nd Day Air Delivery: $20*
2 business days (if ordered by 12pm EST)
Overnight Delivery: $25*
1 business day
Shipping to Alaska, Hawaii or Military APO/FPO?
Click here for details
Shipping Internationally?
Click here for details
*Rates and delivery times for the 48 continuous United States
Returns must be made within 90 days of delivery for a refund of the purchase price, minus the shipping, handling, gift box fee and other additional charges.


text:
I spent almost 2 hours a day in traffic.
I ate out for lunch almost every day.
I wore black pants and dressy blouses and heels almost daily and took the elevator up to the 4th floor to my office.
I worked with a great boss and was surrounded by powerful executives.
I got to go to Cabo & Puerto Vallarta twice on business trips.
And I really disliked almost every second of it.
Well, the corporate end of it. Not the free margaritas :) I was stressed, frazzled, exhausted, and unhappy.
I am not a "corporate" kind of girl. I wanted to be.
But I didn't really know it until I got out of it.
Like most things in life, it's easy to get comfortable.
And when things have to change, we change. And, in my case, our move from CA to AZ changed everything.
I finally got the chance to be what I've always known I was destined to be: a wife & a mom :)
My husband will readily tell you that me being able to be home every day with him is a far better blessing than an extra paycheck (trust me, I'm very thankful for this).
With his schedule like it is, me being able to be at home makes the most sense because if I had a normal 9-5 job I would go weeks on end without seeing him. He also says I'm a nicer person when I'm at home more, and he likes that I can cook him dinner more consistently (haha! Does Mac & Cheese count? ;).
God is so good to have brought me projects and ways to stay creative while I have this extra time. With the exception of missing my family & friends (and the ocean!), I am the happiest I have been in years.
Now, my days are different.
I make lunch at home almost every day.
I wear jeans, t-shirts, and flip flops almost daily.
I usually have to make myself put on makeup and take a shower (wink wink).
I have the time to exercise daily & spend time outside in nature and not in the car stuck in traffic.
I don't go on fun business trips or sit in conference rooms with powerful people, but instead do the mundane chores that must be done & enjoying working from our local coffee shop on my laptop.
I am content.
We had only lived here a few weeks, when Joshua and I started talking about getting a puppy. We'd always wanted one back home, but we'd always lived in apartments where dogs weren't allowed. On a Tuesday night in June, we had dinner with some new friends of ours (our hubby's work together). They had a new puppy. I fell in love with him & asked them if I could steal him :)
NO. But there was one puppy in the litter left.
This little guy has captured my heart. His name has a special meaning because it's one of the first street names I saw here in Arizona.
Hartley.We've had our fair share of scary moments with him. Like the first time I left him alone in the laundry room and he panicked so much that I came home to discover him squeezed back behind the washer & dryer machines covered in lint. And the time he ran down the stairs too fast and started wincing in pain because he hurt his little shins so bad. And the time I rushed him to the ER vet because half the side of his face was swollen because he got bit by a big, mean spider. Oh, and the other day that he face-planted into a cactus.
He's given me so many heart attacks, but so many beautiful moments. I love waking up to see him sitting there staring at me waiting to go on a walk and all of the times he just curls up in a ball next to me and sleeps. Like I said before, I've never been an animal person.I guess this is just real evidence that I really am a different person these days.I think the Arizona sun has been good for me :)


text:
The OC Fair New Year's Eve Block Party will not be returning this year.
After three years of having this event, we found that while Block Party was a fun event for us to plan, and an entertaining event for our guests to attend, it did not meet the measure of success needed in order to continue. We look forward to seeing you at the annual OC Fair and any of the other events that take place at the OC Fair & Event Center. Please visit our calendar of events for more information on our year-round events program.


text:
Faux Bamboo, Set of 12
This item is currently not available.
Additional Information
Faux Bamboo Lasts for Years
- Create your own long-lasting fences, arbors or trellises
- Strong, plastic-coated steel resembles real bamboo
- Resists rot and mildew
- Set of 12 poles
For a permanent structure like a fence, arbor or trellis, you need a material that will retain its strength and good looks over time. This faux bamboo is an excellent choice. Made of plastic-coated steel, the 59" poles are rot and mildew resistant, and will always maintain their original sunny color.
Product Details
- Made of plastic-coated steel
- Poles measure approx. 3/4" diameter 59" H
There are no special shipping restrictions or charges associated with this item. For detailed information about our delivery methods and charges, click here.
We're proud of the fact that this item is shipped to you directly from our warehouse in Vermont, by one of our 250 employee-owners. In-stock items are packed with care and shipped within the next business day to ensure prompt delivery to your home and garden!


text:
By Ikuya Yamada and Yoshiyasu Takefuji
When a server environment is created using virtualization software or a cloud service, the number of servers tends to increase rapidly. Software installation and configuration are required every time a server is created. Further, synchronizing server configurations requires additional effort such as writing shell scripts.
In this article, we will describe how to build a server environment automatically using a relatively new software tool called Puppet. Although this tool is typically used to manage large-scale server infrastructure (such as a data center or a Web service with a large number of users), it can also be used to manage a small number of servers. However, Puppet is a newly developed tool, and the existing documentation and the articles on Puppet are still somewhat cursory.


text:
The Penn State Altoona men's basketball team knows what its like to blow a double-digit lead in a rivalry game.
The Lions did it in early January in a loss at Mount Aloysius.
Wednesday night, they did it again, but this time, they were good enough to escape with a win.
Keyed by a strong offensive performance, Penn State Altoona survived blowing a 12-point second-half lead to hold off Mount Aloysius, 72-69, in a raucous Allegheny Mountain Collegiate Conference thriller at Adler Gymnasium.
"I think the biggest thing we did tonight was made shots," said Penn State Altoona coach Billy Clapper, whose team snapped a four-game losing streak. "Throughout the year, weve struggled at times. For us to shoot 51 percent and hold them to 37 percent, that's that difference in the game."
"They just hit some tough shots." Mount Aloysius coach Lance Loya said. "There were several contested shots with hands in their face, and they hit them. To win big games, you have to hit big shots. They did that tonight."
But the biggest shot of the night was a wide-open jumper by Michael Wigfield that broke a 68-68 tie with 39.7 seconds remaining.
The freshman from Glendale High School took a feed from John Drennan and buried the clutch shot from just inside the foul line.
"Michael has come a long way throughout the year," Clapper said of the former Altoona Mirror first-team all-star. "It's nice to have a local player stand out and step up tonight. This was his best game of the year. He stepped up, knew he could take the shot and hit it."
"I just thought 'I have to make this shot,'" said Wigfield, who had nine points. "I just went where I needed to go and I was wide open."
Wigfield wasn't done hustling, though.
With 14 seconds to go, he thwarted Demetrius Davis' attempt at a layup to tie the game again, grabbed the loose ball that was heading out of bounds and threw it off of Davis to give possession back to the Lions.
"I tipped the ball up and I saw [Davis] got toward it," Wigfield said. "So I went with him thinking he'd go for it, but he stopped. I just kept going, turned and saw he was just standing there, so I threw it off of him."
Penn State Altoona (8-14, 6-10 AMCC) jumped out to an early 25-11 lead and allowed Mount Aloysius (13-9, 9-6) to get within six with six minutes to go.
But Mitch Moyer and Jonathan Ross combined for three 3s to help give the Lions a 40-30 advantage at the break.
Durant Harvin scored a team-high 18 points for Penn State Altoona, while Matt Gehret netted 14. Ross finished with 13 points, and Moyer added 11.
"Our guys did a great job with the effort," Clapper said. "They played hard and I'm proud of them for getting the victory tonight."
Davis had a game-high 20 points, Jeff Stem scored 12 and Dameon Turner added 10 for the struggling Mounties, who have lost three straight and five of their last six games since starting their league schedule 8-1.
The silver lining is that Mount Aloysius holds the tiebreaker over Pitt-Greensburg and has already clinched a postseason berth. The Mounties host Pitt-Bradford on Saturday.
"We just had a tough stretch playing the top four teams in the conference," Loya said. "Those games have taken a toll on us and I think it showed a little bit tonight."
The Lions, who are still battling for the sixth and final playoff spot, host D'Youville on Saturday.
"We've got to get this next one on Saturday," Clapper said. "We've got D'Youville for Senior Night, and I'm excited for that one."
MOUNT ALOYSIUS (13-9, 9-6): Stem 4-13 4-4 12, Wagner 0-0 0-0 0, Turner 5-12 0-0 10, Davis 7-15 2-5 20, LeGrande 3-5 2-4 8, Doyle 3-4 1-3 8, Patrick 0-0 0-0 0, Baughman 2-7 2-2 6, Wyatt 0-0 0-0 0, Barksdale 0-4 0-0 0, Thomas 1-8 3-4 5. Totals 25-68 14-22 69.
PENN STATE ALTOONA (8-14, 6-10): Ross 4-12 2-2 13, Harvin 6-10 4-4 18, Moyer 4-8 0-0 11, Gehret 6-11 1-3 14, Brennan 2-6 1-4 5, Stiles 0-0 0-0 0, Griffith 1-1 0-1 2, Wigfield 4-5 0-1 9. Totals 27-53 8-15 72.
Halftime-Penn State Altoona 40-30. 3-point goals-Mount Aloysius 5-18 (Davis 4-7, Doyle 1-2, Barksdale 0-1, Boughman 0-2, Stem 0-6), Penn State Altoona 10-23 (Moyer 3-7, Ross 3-9, Harvin 2-3, Wigfield 1-1, Gehret 1-3). Fouled out-Gehret, Baughman. Rebounds-Mount Aloysius 38 (Turner 6, Davis 6), Penn State Altoona 41 (Brennan 11). Assists-Mount Aloysius 13 (Turner 4), Penn State Altoona 19 (Brennan 6). Total fouls-Mount Aloysius 20, Penn State Altoona 21. A-623.


text:
2. "Longview," Green Day "Dookie" was Green Day's major-label debut, and "Longview" was its first single (it went to No. 1). There probably was no better song in 1994 that captured that "slacker" mentality (pot smoking! boredom! other things we can't say!). It's also likely the best thing ever to come from being high on LSD, as bassist Mike Dirnt said he was doing when he wrote the bass line.
Full list at Baltimore Sun: HERE


text:
Wall Street Decline Takes Its Toll...
Expanding Use of NGS Has Largely...
LC-MS Gains Favor Due To the...
As Immunotherapy Revolutionizes the Cancer Treatment...
Acorda Therapeutics said today it won a $2.67 million contract from the U.S. Army Medical Research and Material Command (USAMRMC) to support development of AC105 as a treatment for acute spinal cord injury (SCI).
The contract will help fund a Phase II clinical trial designed primarily to assess the safety and tolerability of AC105 in patients with acute SCI. The company plans to open enrollment for this study in the first half of this year.
AC105, a modified form of magnesium, has shown neuroprotective properties and improvement of locomotor function in SCI in preclinical studies, once therapy was initiated within several hours of injury. FDA has granted fast-track designation for AC105 to improve functional recovery of acute SCI patients.
Acorda said in a statement that it expects to apply for FDA orphan drug designation for acute treatment of SCI, and will explore orphan drug designations in Europe and elsewhere in the world.
Acorda licenses worldwide development and commercialization rights to AC105 from Medtronic, which carried out the drug candidate's Phase I study. Under a 2011 agreement, Acorda paid Medtronic $3 million up-front, and agreed to pay up to $32 million tied to regulatory and development milestones. If Acorda successfully commercializes AC105, the company will also pay Medtronic a single-digit sales royalty.
Acorda's rights are exclusive for indications of interest to the company—including SCI, traumatic brain injury, stroke, and all other traumatic and ischemic central nervous system indications. Medtronic and Acorda share nonexclusive development rights in other specific areas, including certain areas of pain and musculoskeletal indications.
At the time, Acorda said it acquired rights to AC105 as a complement to its lead neuregulin drug candidate, Glial Growth factor 2 (GGF2), as well as to the company's preclinical programs in remyelination and spinal cord injury. Acorda envisions AC105 for several nervous system and cardiac indications including heart failure, peripheral nerve damage, stroke, multiple sclerosis, and SCI.
Last month, the company completed its first Phase I clinical trial of GGF2, which explored the drug's safety and tolerability in heart failure patients.
To save this item to your Favorites,
log into GEN Select.
We'll be sure to take you back here after you do.
Not a member of GEN Select?
To comment on this article,
log into GEN Select.
We'll be sure to take you back here after you do.
Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today's life science tools and technologies.
You're all set! Thank you for subscribing to GEN Highlights.
While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
Be sure to add [email protected]
to your Address Book or Safe Senders List.
here for instructions.
If you have any questions about your subscription, click
here to email us or call at (914) 740-2189.
You may also be interested in subscribing to the GEN magazine, an indispensable
resource for everyone involved in the business of translating discoveries at the
bench into solutions that fight disease and improve health, agriculture, and the
environment. Subscribe
today to see why over 60,000 biotech professionals read GEN to
keep current in the areas of genomics, proteomics, drug discovery, biomarker discovery,
bioprocessing, molecular diagnostics, collaborations, biotech business trends, and
© 2016 Genetic Engineering & Biotechnology News All Rights Reserved


text:
Monday, June 2, 2014
The Rotary Club of Daniel Island is pleased to announce that during this, the eighth year of the Rotary Club of Daniel Island Duck Race, they are adding a Stand-Up (SUP) Paddleboard race on the morning of the Duck drop.
The race will begin at 8 a.m. on June 14. Walk-up registration opens at 7 a.m. Pre-registration is $20 and includes two duck adoptions for the Charleston Duck Race. Registration increases to $30 on the day of the race.
The event will take place at Daniel Island Waterfront Park and will feature two courses: one shorter course for the novice and a longer, more challenging course for the experienced. There will be prizes for the winners in each of the four age groups. Board rentals will be available for $10 on a "first come, first served" basis.
A "How to SUP Basics" clinic will be held Friday evening before the race at the "Sundown on the Wando" Festival.
Pre-registration is available online at www.charlestonduckrace.com.
© 2016 Moultrie News an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text:
The stock market rally that led to record highs on Thursday has stalled.
Major U.S. indexes were little changed in early trading Friday.
Earnings news was mixed. Profits at big banks Wells Fargo and JP Morgan came in better than expected, and that helped bank stocks. But UPS cut its profit outlook and said it's seeing a slowdown in U.S. industry.
The Dow Jones industrial average was up 19 points at 15,481 at 10:30 a.m. The broader Standard & Poor's 500 index was flat at 1,675. Both indexes closed at all-time highs on Thursday.
The Nasdaq composite edged up six points to 3,585.
United Parcel Service sank $4.67, or 5.1 percent, to $86.78 after saying its second-quarter and full-year earnings will be less than analysts have been expecting because the company's customers are using cheaper shipping options. UPS also said it's seeing a slowdown in U.S. industry — something likely to concern investors outside of the transportation sector.
Cost-cutting boosted profits at Wells Fargo, and its stock rose 69 cents, or 1.6 percent, $42.58. JPMorgan Chase reported a 32 percent jump in profits. Its stock rose 30 cents, or 0.5 percent, to $55.44.
Anthony Conroy, managing director and head trader for BNY ConvergEx Group, said JPMorgan's credit numbers were strong. "That means the consumer's out there spending and borrowing and propping up the whole economy, and that's a good thing," he said.
Conroy thinks it's likely that stocks will move higher, as long as second-quarter earnings reports at least match the low expectations that investors have. "The three most important things in the next couple of weeks are earnings, earnings, and earnings," he said.
Other stocks with notable moves included:
— Gap rose 54 cents, or 1.2 percent, to $45.30. Three analysts lifted their price targets after Gap posted revenue at stores open at least a year that was better than the market was expecting.
— WebMD jumped $7.09, or 27 percent, to $34.19 after the medical website operator sharply raised its forecast for its second-quarter results, citing strong demand from advertisers.
The yield on the 10-year Treasury note fell to 2.54 percent from 2.57 percent.
A measure of consumer sentiment from the University of Michigan came in lower than expected for this month.
Markets elsewhere were mixed. In Europe, Britain's FTSE-100 rose 0.2 percent, and Germany's DAX index was up 0.6 percent. The CAC-40 in France posted a slight decline. The Nikkei in Japan rose slightly, while stocks in Korea and China fell.
The price of crude oil rose 26 cents to $105.17 per barrel in the U.S. Other energy prices also rose. Gold slipped 40 cents to $1,279.


text:
on June 22, 2013 - 11:38 PM
Sister is busy.
She typically is, of course, in the way that religious women often seem to be. But today, at midday on a Friday in spring, Sister Ann Therese Kelly has more going on than usual.
A window is being born.
In a stairwell at Villa Maria College on Pine Ridge Road, Sister Kelly watches as the finishing touches are put on the installation of her newest work of art.
The 16-foot window is so freshly fixed in place that some of the caulking is still damp.
"There it is!" Sister Kelly exults, gazing at the window.
Not that it wasn't tricky. Specialists from a Pittsburgh glass company, Hunt Studio, told her that some of the swooping pieces of colored glass required leads in lengths as long as 6 feet.
"That makes it hard," said one of the installers.
"As the artist, I have to stick to my style," said Sister Kelly, smiling,
Her newest window has a name: "The Song of Creation." It springs – as so much of her work always has – from Sister Kelly's love for St. Francis of Assisi, and in particular for his poem "Canticle of the Sun."
"Be praised, my Lord, through all your creatures, especially through my lord Brother Sun …"
To Sister Kelly, the poem by the saint – a celebration of the earth and its creatures, in relation to the God who created them – is about more than joy over the wonders of nature.
It's about transformation of self, and the world around us.
"Do you know what alchemy is?" asked the 58-year-old religious, her gray eyes bright behind metal-framed glasses, a wooden cross on a cord around her neck. "It's changing properties of lead into gold. They tried for years."
"But spiritually, it means we can change ourselves," she said. "We can become better than ourselves."
As an artist, Sister Kelly has spent her life pursuing alchemies. Starting with simple materials – colored glass, heat, labor – she makes art that hangs in witness to her vision all over Western New York and elsewhere in the country.
You may have seen her work in churches in Derby, Elma or Buffalo. You may have seen it in the Junior League Show House, or in private homes. Now, at what may be the peak of her career, she has opened a studio in Buffalo – as a way of teaching others what she has learned.
Sister Kelly, you see, knows transformations. Her life has been full of them.
Born in Niagara Falls, Ann Catherine Kelly grew up in a farmhouse in Wheatfield with her parents and four siblings. Her father, a chemist who worked at DuPont, was a musician in his spare time, and taught the young girl how to play banjo and guitar.
"I bought my first guitar before I entered the convent," Sister Kelly said. "It was the era. The Singing Nun was really big. 'Dominique, –nique …' " She grinned.
She attended Bishop Gibbons High School, graduating in 1972. She spent a year at Niagara County Community College. Then, at 19, she entered the Felician order, the same order of religious women who taught her in high school.
When Sister Kelly entered the order, she dropped the middle name she had received at birth – Catherine was her mother's name – and instead chose "Therese" as part of her new name. That choice amazed some members of her family even more than her decision to enter the convent – though the young sister didn't find that out right away.
It was years later that someone told Sister Kelly what the surprise was all about. Long before, they told her, her mother's father – Sister Kelly's grandfather – had offered intercessory prayers to St. Therese of Lisieux, so that one of his own daughters would enter the convent.
That didn't happen. But Ann Catherine Kelly did.
Sister Kelly loved life in the convent, even though at times it was a struggle.
Part of that adjustment may have been because she didn't speak the Polish language, and the Felicians had many Polish-speaking sisters at the time, she said. Part of it may also have had to do with the time, the 1970s and early 1980s, when much about religious life was changing.
Moreover, Sister Kelly was trying to find her way as an artist, at the same time as she was trying to make her way in her vocation.
She stayed in the convent for eight years. Then, in her late 20s, she left.
Once outside the community, Sister Kelly finished her undergraduate degree, a bachelor's in art at Buffalo State College. She also worked on her art career.
When she came back to the convent, after two years, Sister Kelly said, she felt better prepared for the challenges ahead of her.
After returning to the order, Sister Kelly enrolled at the Rochester Institute of Technology, where she finished her master of fine arts degree in 1991.
"If I hadn't done that, I wouldn't be where I am today," she said recently, sitting in front of a wall of windows in her spacious Buffalo studio, which has been fashioned out of a space that used to be a laundry room in the Villa Maria convent on Doat Street. "You have to be obedient to who you are. I have to be obedient to my talents, so I can serve better."
What Sister Kelly said she has learned, by being both inside and outside the convent at various times in her life, is that she wouldn't be happy as a nonreligious trying to fit into the contemporary art world. Just as she likely wouldn't be happy as a religious without the opportunity to create art.
Here, then, is alchemy: fusing two worlds, that of art and that of spiritual life, to form one life.
"I always wanted it to work together," Sister Kelly said.
In the St. Columban Center in Derby, 18 panels of vibrantly hued glass in the chapel reveal an earlier phase of Sister Kelly's career.
She designed the windows in 1996, to commemorate the 50th anniversary of the founding of the retreat center. From right to left, the windows – which now form a backdrop to the chapel's altar – depict scenes from nature, ranging from a sun and dove to the moon. In between are images of a tree with extended roots, human figures, a pond and waterfall, and greenery.
The windows glow in hues ranging from purples and blues to greens, yellows, reds and oranges.
The scenes draw on the Canticle of the Three Young Men, from the Old Testament, said Sister Kelly.
Monsignor James E. Wall, who was director of the center when the windows were commissioned, said the design of the windows came from the artist. "Sister Ann Therese had an idea of her own," he said.
He said the windows are interpreted in different ways by people who see them. They are complex, and yield multiple meanings on repeated viewings.
"People get different things out of it," said Wall. "The left side is more the feminine, the right side is the masculine. It's the cycle of life."
Wall said he was thrilled when he saw what Sister Kelly had done with the windows.
"Everything in it was her imagery," he said. "I was very pleased when I saw it."
Making stained-glass windows is a time-consuming process. An artist begins well in advance of choosing colored pieces of glass in transparent cathedral, opaque and opalescent styles.
Sister Kelly starts by designing her patterns, based on the needs the window will serve and the location in which it will be installed. Her windows for the Derby retreat house, which frame views of a lush landscape, used natural imagery to set off the scene.
At Niagara University, her series of windows commemorates achievements and history of the nursing program.
And, in two recent Junior League show houses, her windows used fused-glass techniques to add privacy and sophistication. She completed the Knox mansion project with students.
At Villa Maria, the new window designed by Sister Kelly is part of the exterior wall near the college library. She used Hunt Studio to help with phases of the project.
"When it's architectural, it's important to use a large studio, because of the precision" involved in the installation, Sister Kelly said. "To make a mistake is very expensive."
The Pittsburgh studio handled cutting and leading of glass as well as installation of the window. Sister Kelly said that saved time on the project, which took her about a year.
At the college, her work was received with praise. According to one administrator, Sister Kelly's artwork is a natural fit on the campus.
"The Felician sisters were always known for their love of art and music," said Sister Mary Marcine Borowiak, vice president for development at the college, which was founded in 1960.
In the college window, Sister Kelly created imagery to depict the continents of the world, setting the green colors of the land masses off with blues for the oceans. In the continents, glass pieces are covered with different kinds of leaves – gingko, maple and more – to reflect native greenery that grows around the world.
"I did a lot of research into which type of leaves to use for each of the continents," Sister Kelly said.
She sees her new window as yet another interpretation of St. Francis' poem.
"It's a transformational poem about the transformation of the earth," she said. "It's about diversity. About caring for the poor."
Throughout her career, Sister Kelly has been a teacher. She taught as an adjunct faculty member at colleges in Western New York, including Niagara. More recently, Sister Kelly's career took her in 2000 to New Jersey, where she held a faculty position at Felician College.
Her return to the Buffalo area, in 2010, was largely made for personal reasons. Her father died in 2005, at 73. Nowadays, her 83-year-old mother – the Catherine she was named for – struggles with some health problems that require care and support from children and family members.
Sister Kelly, who lives in Elma in a house belonging to the order along with a few other sisters, said she feels she made the right decision in coming back to Buffalo; her mother has been living in a nursing home for a year.
"It's so important to be there when that happens," she said.
When she returned, a new glass and art studio – in the former convent laundry – awaited her.
Filled with paint supplies, slabs of colored glass, work tables and stools, computers, books and musical instruments, the busy, open space reflects the many paths Sister Kelly's life has taken to this point.
Her new studio enables Sister Kelly to teach and mentor students in one-on-one and small group settings – something she hopes to continue to do for years to come. She blogs about her work at www.sisterkelly.blogspot.com.
Once again, an alchemy: the combination of roles and duties, in her current place in life; the daughterly, along with that of a teacher and mentor, an artist and a member of a religious community.
"I feel that I'll stay here, now," Sister Kelly said.
In one corner of Buffalo, Sister Kelly's glass art intersects in a poignant way with the life of a well-known local religious woman, Sister Karen Klimczak.
It was at St. Columba-Brigid Catholic Church in the city that Sister Kelly received a commission to create one of her biggest windows to date, a giant panel that forms the dramatic backdrop to the church's main altar.
The window was installed in the new church that was built to replace a century-old structure that burned down in 2004.
When word came that St. Columba-Brigid would be rebuilt, Sister Klimczak – who worked at the church – and the Rev. Roy Herberger, the pastor, engaged Sister Kelly to create a stained glass window that would symbolize the rebirth and renewal of the church at Hickory and Eagle streets.
The pair held a number of meetings with Sister Kelly while the windows were being designed and crafted, Herberger recalled. Then, in 2006, Sister Klimczak was killed inside the halfway house she ran for newly released prison inmates on Grider Street.
When the new church opened in 2007, with Sister Kelly's window as its chief work of art, the symbolism – related to both the rebirth of the parish and the slain nun – were striking.
"Sister Kelly made it what it is," Herberger said. "She gave it the artistic inspiration."
The window features a large central cross design, in brown glass, in front of tones of red, orange and yellow, like outreaching flames or rays of light. Blue and white tones at the top and bottom root the image and provide a contrast to the warm colors.
"The idea is almost the phoenix, rising from the ashes," Herberger said. "So that our parish would rise from the destruction of the ashes."
Coming in the wake of two terrible losses, the fiery, dynamic glass creation gave the members of the parish something hopeful and positive to ponder, the priest said.
That had incalculable value, he said.
As for Sister Kelly, when she thinks of her work, she thinks of some song lyrics that she heard not long ago. They seem to fit.
"I want to color the dark with the light," the lyrics ran.
Or, as she named her new glass studio:
email: firstname.lastname@example.com


text:
Branch Manager
What do you like about working at the Credit Union? More than anything, I like the people and the atmosphere. It is very welcoming and full of people with good character, and sincerity. We are very community oriented and build real, genuine relationships with those that we work with out in the communities that we serve.
What's your most memorable moment as a volunteer for the Foundation? Wow, it's hard to single out one of many. Working with parents that have not had the financial education that most have and seeing how much of an impact I have in what I say. Also, seeing the recipients of our work is always very gratifying whether it's during our work with kids, cancer patients, or those who are just down on their luck.
How did you come to be an employee with the Credit Union? I was referred to the Credit Union by our Manager of Community Relations, whom I worked with at another financial institution in the past.
Would you recommend SCE FCU as an employer? Without a doubt. I would recommend SCE FCU as an employer for all the reasons that I mentioned and for all the reasons I didn't because we would have to add another page if I did.


text:
'Tobaluka' | Stretch Cotton Brush Print Pants by BOSS
Style No. 50268118
Free Shipping
- These stretch cotton pants by BOSS feature two side welt pockets, a zip fly with hook-and-bar closure, and two back welt pockets. An allover brush print completes this bold look.
- Model is 5' 10" with a 32" bust, 24" waist, and 35" hips, and is wearing size 2.
- Mid-rise
- Zip up fly with button and hook-and-bar closure
- Two side welt pockets
- Brush print
- Slim, tapered leg
- Stretch cotton