text:
As Immunotherapy Revolutionizes the Cancer Treatment...
Expanding Use of NGS Has Largely...
Wall Street Decline Takes Its Toll...
LC-MS Gains Favor Due To the...
Cell-based assays continue to provide powerful tools to fuel drug discovery. However, costly late-stage failures are driving the industry's search for improved approaches and novel tools for interrogating cells. Throughput, reliability, cost, and physiologic relevance of cellular models for predictive toxicology remain central issues in the field.
Visiongain's "Cell-Based Assays" conference next month will feature topics ranging from technological advances in cellular models to challenges to traditional drug discovery paradigms. Additionally, presentations will provide the latest developments in stem cell biology and demonstrate how applying engineering/computing principles to living systems could revolutionize the design of new therapies.
"In many ways, progress in the drug discovery industry has been quite disappointing in the last 10 years," reports Mark Slack, Ph.D., group leader of cellular assays, Evotec.
"The inertia and lack of productivity relate to failures in efficacy, poor clinical translation, and stagnant methodologies. The old one-gene, one-drug paradigm is no longer relevant, giving way to phenotypic approaches, capturing targets in their functional background. The landscape is beginning to change with an emerging paradigm that considers the physiology of diseases and the whole organism.
"We are seeing that high-throughput screening formats are employing more physiologically relevant cellular models including use of primary cells and label-free, nonintrusive methods to interrogate new compounds. One rapidly emerging area is the use of stem cell technologies.
"Because of difficult ethical issues in the generation of such cell lines, landmark work has studied and now demonstrated that it is possible to induce the reversal of somatic tissues into stem cell populations (i.e., induced pluripotent stem cells, or iPSCs).
"We can perform assays from affected patients via iPSC technologies and generate cells expressing the disease phenotype. These will be very useful for drug discovery for specific diseases such as Parkinson and Huntington diseases."
Another area that has benefitted from technological advances is automated electrophysiology. Tiny patch clamp electrodes are now applied to individual cells in a 384-well format, allowing the screening of tens of thousands of compounds.
"This has been an underexploited target class," Dr. Slack says. "With the emergence of automated patch-clamp assays, a major bottleneck was overcome. However, we now need to deal with the high cost per data point and the relatively low throughput and efficiency of the devices."
According to Dr. Slack, one of the more exciting recent developments slowly establishing itself in mainstream drug development is atomic force microscopy (AFM). Developed as an add-on to enhance the scanning tunneling microscope, AFM adds an atomically sharp tip.
"By monitoring the surface of biological specimens with the sensitive tip, one can actually see the cellular membranes and even their subcellular components at high resolution. Ultimately, these and other emerging technologies are providing more physiologically relevant models."
Unanticipated toxicity and adverse drug reactions after licensing a drug are the leading causes of late-stage attrition and withdrawal of drugs from the market. "Up to 30% of compound failures happen due to toxicity and issues of clinical safety," notes Neil A. Hanley, M.D., Ph.D., professor of medicine at the University of Manchester.
Liver toxicity tops the list of drug-induced injury. "The underlying mechanisms of damage are quite complex and not completely understood. A major issue is that such toxicity is not reliably testable in a cell culture system, nor completely accurate in animal models." Dr. Hanley suggests that, not only are better cellular models for hepatotoxicity needed, but that generating hepatocyte-like cells from human embryonic stem cells (hESCs) or induced pluripotent stem cells (hIPSCs) may hold the answer as an assay of choice.
"In theory, these stem cells could be utilized to generate all the different cell types of the adult liver. This is a key advantage that may allow better mirroring of the complexity of an intact organ. There have been a number of advances aimed at differentiating hESC into liver cell types. Three components needing to be addressed are soluble growth factors, support cells, and an extracellular matrix medium."
Dr. Hanley indicates that there are many challenges that remain before this system is ready for more widespread use. "Many academic laboratories can reliably generate progenitor-like cells. That is about three-fourths of the journey. The last one-fourth, getting to the mature liver cell, is most likely contingent on the precision of preceding steps plus optimizing conditions for the final differentiation.
"An example of the last step is optimizing extracellular matrix composition to provide a scaffold for growth and differentiation."
Before big pharma can utilize hESCs for hepatotoxicity, testing the industry must also tackle issues of scale-up and consistency of production, suggests Dr. Hanley. "Scale-up, the bioprocessing step, is a huge science in itself."
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Novum Pharma recently raised the price of an acne cream by over 3,900% in less than a year-and-a-half and Mylan increased price of EpiPen from $100 to $608 . Do you think pharmaceutical companies need to be subjected to price controls?
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5 simultaneous users.
A daily email newsletter of concise, translated briefs covering some of the key political, cultural, economic and opinion pieces appearing in the media of the 22 Arab countries, Iran and the Arab Diaspora.
Miami University has a long and proud tradition of student involvement in both radio and television productions. This exhibit will celebrate five decades of students in broadcasting. Many of these productions can be found online in the WMUB Archives. For questions about the exhibit, contact Marcus Ladd at email@example.com or (513) 529-0462.
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text:
Source: E90 Post
quote: Seriously, though, if BMW thinks people are willing to pay for this, then it's worth putting the money into research and development.
quote: I'm looking at you, Fisker and Tesla.
quote: Engines can't be over-reved anyway because of rev-limiters.
quote: IMO, this BMW 7-speed manual concept is a waste. What is the point of a manual transmission if the shifter is not physically connected to the transmission and the driver does not have full control? Not everything needs to be build to the lowest common denominator idiot. If you can't drive a proper manual, don't buy one.
quote: The 135i is a nice car. Lucky wifey!
quote: That being said, I'd buy the 135i before I'd buy the Boss. The 135i is more comfortable and luxurious. And, anyway, if you're gonna buy a Mustang, it might as well be a GT500 or the 2011 GT350.
quote: If you are into drag racing, I agree.
quote: The Boss 302 starts at $42k. Sorry Ford, but the base Corvette is still a better buy.


text:
- Flat Rate Shipping. Any Size Order! -
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HOME San Diego Chargers Gear San Diego Chargers Womens San Diego Chargers Womens Accessories San Diego Chargers Womens Accessories Jewelry (33 items) Product ID: 1252299
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- 3-Piece jewelry set
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text:
Missing woman case in West Allis leads to shooting of Adams County deputy
Shooting suspect dies Wednesday
Authorities said a missing person case in West Allis led to a shooting in Adams County of central Wisconsin that left a sheriff's deputy wounded and the suspect dead.
West Allis Acting Police Chief Charles Padgett said his department got a call around 6 p.m. Tuesday about a 52-year-old woman who was missing under suspicious circumstances. She had a no-contact order against her 55-year-old husband, Thomas Costigan, because of recent domestic incidents.
Authorities tracked them to Adams County, where the shooting happened about 7:30 p.m. in a home in the Town of Big Flats.
Sheriff Sam Wollin said Costigan fired several shots at two officers, wounding the deputy before shooting himself. He said the officers did not return fire.
The deputy, 43-year-old Todd Johnson, is in good condition at a Marshfield hospital.
Copyright 2013 by WISN.com. The Associated Press contributed to this report. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
'Rhett' | Extra Slim Fit, Super 120 Italian Virgin Wool Sport Coat by BOSS
Style No. 50262531
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This extra slim fit sport coat by BOSS crafted in Italy's lauded Lanificio Tesse Biella mill from ultra fine super 120 virgin wool, which ensures a soft and luxurious feel that distinguishes it from other sport coats. This piece is finished with an all over micro-thatched design, notched lapels, and a two-button front.
Model is 6'2" with a 32" waist, 40" chest, and is wearing size 40R.
Model is 6'2" with a 32" waist, 40" chest, and is wearing size 40R.
- Extra slim fit
- Notched lapels
- Two-button front
- Contrast micro-check undercollar
- One open slant pocket at chest
- Two flap pockets with piping at waist
- Four-button detail at sleeves
- Interior pockets: One open welt pocket with piping, one welt pocket with a button closure and piping, one open ticket pocket with piping
- Double back vents
- Back length: 73 cm (28.7 in)
- Super 120 Italian virgin wool
- Made in Italy


text:
Mistakes continued to haunt the Stetson Hatters on Friday night in their opening game at the Bright House Networks Invitational Tournament at Melching Field.
The Hatters were charged with four early errors in their matchup with Central Michigan, allowing the Chippewas to take a 6-5 victory. The game capped a day that opened with Connecticut taking a 5-2 victory over Ohio State.
The tournament will continue on Saturday when Central Michigan takes on Connecticut at 1 p.m. The Hatters and Buckeyes will then square off in the late game, which is scheduled for a 7 p.m. start.
The loss dropped the Hatters to 2-5 on the year while CMU improved to 3-5.
The Chippewas scored a single run in the first inning and two more in the second off Stetson starter Kurt Schluter (0-2). Jordan Adams singled in the first run to capitalize on the first Hatters error of the night. Logan Regnier then drove in two in the second with a two-out single.
The Hatters got one run back in the bottom of that inning when Garrett Russini blasted a solo homer off Central Michigan starter Jordan Foley (2-0). The Chippewas got that run back in the fourth when Neal Jacobs, who opened the inning with a double, scored on a squeeze bunt by Alec Ornelas.
CMU added a run in the fifth when Pat MacKenzie scored from third on a throwing error by Russini after Cody Leichman struck out.
Stetson got a pair of runs back in the sixth inning when Patrick Mazeika doubled and scored on a Mitchel Brennan fly ball to left that was misplayed by Tom Lally, who then compounded the mistake with a throwing error. Carlos Garmendia followed with a single to right to score Brennan.
Schluter's night ended in the seventh inning after allowing a walk and a one-out double. He tied his career high with 10 strikeouts, but allowed four earned runs on seven hits over 6.1 innings. Joe Dye came on in relief of Schluter, and got a high bouncing ball to second for the second out of the inning, but MacKenzie scored from third on the play.
The Hatters got a pair of runs back in the seventh inning, but missed out on a chance to score much more. Stetson loaded the bases twice in the inning, getting a run on a fielder's choice ground out and a single by Brennan, but left the bases loaded when relief pitcher Dylan Rheault came in and struck out Konner Lutz to end the inning.
The Hatters threatened again in the eighth inning, but left two more runners on base when Mazeika lifted a long drive into right-center that was run down by Nick Regnier on the warning track.
The Hatters will try to snap their three-game losing skid on Saturday night against Ohio State when sophomore right-hander Josh Powers (0-1, 2.92) takes the mound against the Buckeyes' senior right-hander Brad Goldberg (2-0, 0.00).


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Think ethanol is environmentally friendly? Think again
Editor's note: This opinion piece written by William F. Shughart II, the J. Fish Smith professor in public choice has run in several newspapers across the country, including the Kansas City Star, The Sacramento Bee, and the Anchorage Daily News.
Published Tuesday, Mar. 12, 2013
America's prairies are disappearing at the fastest rate since the 1930s' "Dust Bowl."
Given the pace at which U.S.
Driven in large part by government biofuel mandates on oil
refineries, U.S. farmers converted more than 1.3 million acres of
grassland into corn and soybean fields between 2006 and 2011, according
to a newly published study by scientists at South Dakota
To read the rest of the column click here.


text:
French (minor)
What can the Charleston Southern French program do for you?
- You can study French on any level from among the 12 courses we offer.
- You can complete a minor in French (6 courses on any level).
- You can learn about the French culture.
- You can participate in a study abroad program to Quebec, Canada, or Paris, France.
- You can teach English in a French high school for a year.
A minor in French consists of 18 hours.
Advanced placement is normally determined by scores on placement tests administered by the department and must be approved in writing by the department chairperson.
Elementary and Intermediate language courses (100 and 200-level) must be taken in numerical sequence and should be completed by the end of the sophomore year. One hour of laboratory work per week is required in addition to the class sessions for these courses.
Minor Studies (12 hours)*
All students must have at least 125 hours to graduate. Students must meet theResidency Requirements described in this catalog.


text: Six Join Stetson Sand Volleyball For 2012-13 June 14, 2012 DeLand, Fla. - Stetson Sand Volleyball Head Coach Tim Loesch is proud to announce the addition of six players to his squad for the Spring 2013 season. Four junior college transfers and two freshmen will add depth to the Hatters in their second year as a varsity program. Arriving at Stetson this fall as freshmen will be Kendale Speyerer (Winter Haven, Fla.) and Madison Tormey (Orlando, Fla.). Speyerer played three seasons of varsity volleyball at Lake Region High School where she led Polk County in digs. She served as president of the Girl's State Executive Board, was a National Honor Society member and ranked in the top five percent of her graduating class. Tormey graduated from Olympia High School in 2011 and is currently studying at St. Andrew's School in Nassau, Bahamas to get her International Baccalaureate (IB) Diploma. The other four members of the incoming class will be juniors, including Lake-Sumter Community College teammates Jordann Dierickx (Jacksonville, Fla.) and Kirsten Germeroth (Tavares, Fla.). Germeroth recorded 571 digs as a sophomore for the indoor team to rank among the NJCAA national leaders while Dierickx, the team's primary setter, racked up 1,056 assists, 316 digs and 85 kills. The latter was a First Team All-First Coast honoree as a senior at Jacksonville's Providence High School in 2009 and is a descendant of legendary Notre Dame football coach Knute Rockne. LSCC's interim head coach in 2011 was Jim Hoffman, father of Stetson sand volleyball rising senior Alisha Hoffman. Erin Robertson (Tulsa, Okla.) and Kara Young (Port Orange, Fla.) round out the incoming class. Robertson tallied 66 kills, 131 assists, 37 aces and 208 digs as a sophomore at St. Petersburg College; prior to SPC she was an All-State honoree and honor student at Bishop Kelley High School in her native Tulsa. Robertson helped lead the BKHS Comets to three Oklahoma state titles. Young registered a team-high 540 digs in 2011 as a sophomore at Brevard Community College and was among the top 50 nationally in that category. She earned an FCSAA Defensive Player of the Week award. A 2010 graduate of Spruce Creek High School, the local product has focused her training on sand volleyball in recent years with several titles at beach events in Daytona Beach and St. Augustine to show for it. These six players join sophomore Catherine Coston (Pierson, Fla.), who transferred to Stetson in January 2012 from Southeastern University and will also play on the indoor team, to increase Stetson's sand volleyball roster from 13 players in its inaugural season to 17 in 2013. The Hatters went 9-8 overall in 2012 and finished second in the inaugural Atlantic Sun Conference Championships. Slated returnees include A-Sun Freshman of the Year Julie Bassett (Wadsworth, Ohio), A-Sun All-Tournament Team selections in junior Katie DiGirolamo (Bradenton, Fla.) and sophomore Stephanie Marin (Naples, Fla.) as well as Bassett's partner in the AVCA Collegiate Sand National Championships, junior Kaley Melville (New Germany, Minn.) FACEBOOK - Stetson Athletics (facebook.com/stetsonhatters); TWITTER - @StetsonSID (twitter.com/stetsonsid)Print Friendly Version More Headlines


text:
Source: Samsung
quote: Minus the part where Mick got it wrong in the article and he got it right.
quote: SEOUL, Korea – April 26, 2013 – Samsung Electronics Co., Ltd. today announced revenues of 52.87 trillion won on a consolidated basis for the first quarter ended March 31, 2013, a 6-percent decrease from the previous quarter. Consolidated operating profit for the quarter reached 8.78 trillion won , representing a 1-percent decline (QoQ), while consolidated net profit for the same quarter was 7.15 trillion won .


text:
Nothing Beats Immunoassays for Sensitivity, Specificity,...
As Immunotherapy Revolutionizes the Cancer Treatment...
Adapting to Evolving Business Environments Is...
Process Development Jobs Still the Most...
Novartis agreed to license ImmunoGen's Targeted Antibody Payload (TAP) antibody-drug conjugate (ADC) technology to develop new anticancer therapeutics for an undisclosed target, in a deal that could top $200 million.
The licensing deal is the second between the companies under a collaboration launched in 2010. For each license, ImmunoGen receives up-front and milestone payments totaling about $200 million, not including royalties. Novartis has responsibility for developing, manufacturing, and marketing any products that result from licensing agreements with ImmunoGen.
The Novartis collaboration, now in the preclinical phase, gives the pharma giant the right to take a defined number of exclusive, single-target options that provide rights for single-target licenses, on pre-negotiated terms, to specified targets during the respective option periods.
As of June 30, Novartis had taken one license to two related targets—one on an exclusive basis and one on a nonexclusive basis, according to Immunogen's most recent quarterly Form 10-Q, filed Aug. 29 with the U.S. Securities and Exchange Commission.
ImmunoGen's TAP technology uses a tumor-targeting engineered antibody to deliver one of the company's highly potent anticancer agents specifically to tumor cells. TAP uses engineered linkers that keep the payload attached to the antibody while in the bloodstream, then controls its release and activation inside a cancer cell.
The first product applying ImmunoGen's TAP technology is the Roche drug Kadcyla® (T-DM1 or ado-trastuzumab emtansine) for patients with HER2-positive, metastatic breast cancer, approved by the FDA in February and marketed in the United States by Roche subsidiary Genentech.
ImmunoGen said it has four wholly owned clinical-stage product candidates and additional compounds in clinical phases through collaborations with Amgen, Bayer HealthCare, Biotest, and Sanofi.
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While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country's most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?
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text:
Danielle Bradbery, the Texas teen who had never performed in public but became the season 4 winner of The Voice Tuesday night, has a record deal.
And not just any record deal: She's been signed by Taylor Swift's label.
Just one day after Bradbery picked up the big prize, making her coach, birthday boy Blake Shelton, proud, Nashville's Big Machine Records scooped up the talented 16-year-old singer.
She is slated to begin recording next week, Just Jared reports.
Along with Swift, Bradbery's new label mates include country superstars Rascal Flatts and Tim McGraw.
Bradbery, the season's youngest contestant, attended high school in Cypress, Texas, before impressing The Voice's coaches with her perfect pitch and vocal maturity as she tackled songs by veteran singers.
Usher called her talent "God-sent."
Shelton said Tuesday of Bradbery, "I think it's the most important win we have had so far on The Voice because Danielle is the first winner on The Voice that had no professional experience in the past."
"People are just wrapped around her finger for a reason," Shelton said. "God sprinkled just a little bit more on Danielle Bradbery than he did the rest of us and I'm just glad to call her a friend."
The Voice's Danielle Bradbery Joins Taylor Swift at Big Machine Records
Jim Spellman/WireImage; Tyler Golden/NBC


text:
What is your reaction to plans, nearing fruition, for a Route 15 Shamokin Dam Bypass?
Way,way,and way OVERDUE!
4 Agrees | 0 Disagrees | Report Abuse »
I wonder how much money it will costs the local businesses now that most of the traffic will be going around them.
2 Agrees | 2 Disagrees | Report Abuse »
About the local businesses, people will still go there to shop. It will just be easier to go in and out. I doubt that people who are just trying to get from point A to point B are interested in stopping to shop at random stores.
I have relatives in Maryland, and the most direct way to get to where they live is down Route 15, and I always dread going through that area with all the lights and congestion.
6 Agrees | 0 Disagrees | Report Abuse »
To garder54: I remember when they built the beltway back in the 70's the same concern was made about the businesses on the Golden Strip and they all seem to be doing fine. Granted, it did have a more negative effect on the businesses on Lycoming Creek Road, but they have adapted. The demographics have changed over the years and this new project is decades overdue.
6 Agrees | 0 Disagrees | Report Abuse »
I applaud this agenda!! I have traveled Rt 15 for business more than 40 years and this is really great news.
1 Agrees | 0 Disagrees | Report Abuse »
Why can not afford it.
0 Agrees | 0 Disagrees | Report Abuse »
Way overdue
1 Agrees | 0 Disagrees | Report Abuse »
I agree, garder. I do wonder about the local businesses. The "going shopping" thing obviously is not written by someone from down there. I go through there all the time and will LOVE the fact that I don't have to go through all the stop lights and traffic. Yet, it often provides a nice stop off point at Sheetz or McDonalds or wherever coming home just for drink and the bathroom. I guarantee once that road is built I won't be in any of those places again. I'm willing to bet I'm not the only one.
I don't know that this is a reason not to do it--it will make ME happy--but the concern is valid.
0 Agrees | 0 Disagrees | Report Abuse »
Artfold, Fairly good point about the Golden Strip...and about Lyco Creek Rd., for that matter. I, for one, am very glad they built the beltway so I can go on the Golden Strip as rarely as I possibly can.
People completely lose any ability to drive when they get on the strip. It's like there's a break in the space-time continuum at either end of the strip that makes us forget we've ever operated a vehicle before.
1 Agrees | 0 Disagrees | Report Abuse »
I don't think shopping as an overall will be affected. I think it will decline at first, but in the end won't make much of a difference. There are two types of people on that road. The first type are the people that are there to shop and eat, the second type are the people just trying to get through that mess to continue their trip. The second type of people will be free to avoid all that extra traffic.
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text:
The teen literary journal "Canvas" offers a multitude of ways for readers, writers and artists to connect.
The Writer
Digital Editions / Renewals / Gifts
Oscar weekend! Check out TW interviews with screenwriters who have successfully taken stories from idea to page to lights, camera, action.
Newspaper man Sam Quinones explores the labyrinthine twists and turns of extended storytelling.
Editor Alicia Anstead talks about craft with Ariel Schrag.
A guide to sifting through MFA programs for the best in poetry.
A reporter returns to her first love, and finds she can explore her journalistic obsessions.
Eliot said: "Only those who will risk going too far can possibly find out how far one can go." We hope this issue finds you sitting with writers whose work engages you and pushes you far. And again farther.
Competitiveness and striving and self-commodification or envy will ruin your writing.
In honor of National Poetry Month, the best poets in America share the poets and poetry that have influenced and inspired their own writing.
Editor Alicia Anstead talks about craft with novelist Ann Hood.


text:
LISBON - Columbiana County Common Pleas Judge Scott Washam has denied the request of Joseph Eltringham to have a 48-hour period of electronically monitored release prior to his upcoming sentencing for charges of aggravated robbery, felonious assault and intimidation.
Eltringham, 45, East Rochester Road, East Rochester pleaded guilty to the charges on Aug. 23 and faces up to 21 years in prison, although Assistant County Prosecutor Ryan Weikart said he will ask for 10 years at the upcoming sentencing hearing on Nov. 1.
In Friday's ruling on Eltringham's motion, Washam stated he considered on one hand the high-level felony offenses, which included the intimidation of the elderly victim, World War II veteran Robert Kastelic. He also said he considered the prosecution's additional concerns about Eltringham becoming a flight risk after pleading guilty.
On the other hand, Washam considered Eltringham's lengthy military service to his country and the fact he had no prior criminal record. Eltringham had spent 23 years serving with the National Guard.
Washam called the fact bail was raised following the preliminary hearing in Columbiana County Municipal Court shortly after the attack "of great significance."
At that hearing, Kastelic had taken the stand, still bruised from the attack, and testified about the night Eltringham had come to his home, grabbed the then 86-year-old Kastelic by the neck, threatened to kill him and severely beat him over a 30-minute time frame. Eltringham then reportedly stole $400 from Kastelic's wallet, asked if he could keep a ladder he had previously borrowed from Kastelic and went after title paperwork for Kastelic's pickup and his home.
Washam additionally wrote in his ruling his research had not revealed another case where a defendant, unable to post bail, was released on electronic monitoring.
"The seriousness nature of these offenses and the life-threatening injuries caused to the elderly victim outweigh in the mind of the court any private benefit that may be gained by granting the defendant's request," Washam wrote.
Defense attorney Richard Hura and Eltringham had requested he be allowed time in a hotel to spend with his family, including his elderly mother.


text:
|Welcome to the MANGA Forum.
|You will have to register before you can post: log in or sign up at the top of the page to proceed. To start viewing messages, select the forum that you want to visit from the selection below.
A few monthes ago, I heard from a friend of mine, that there was a movie that was made documenting the events of a past war in the middle east (Not the Iraqi war, it could have been Operation Dessert storm, but IDK), but it wasn't with actual actors, but instead it was an anime. It wasn't a branch from a series either, it was just a movie documenting the war. I have no idea what the name of this movie is, but I was wondering if anyone had heard of something similar to what I'm talking about?
there is an anime series called Apocalypse Meow based off of the manga Cat Shit One. It has anthropomorphic animals acting as soldiers and it takes place during Desert Storm (the rabbits are the United States military. usagi means rabbit in Japanese and it is used as a play on words for U.S.A. G.I.) I hope this helps, might not be the series you're looking for.
But thanks for helping anyway. I've heard of that series before.
sorry i couldn't be more helpful. i just thought it might be that since you mentioned it was anime and in the middle east. i'll let you know if i come up with anything else.
i heard of that too
"This form is the symbol of our determination! Foolish creatures, drunk on Spiral Power!"
Love... is just a different kind of pain.
At least I know that this movie is out there, all I have to do now is look for it.


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Now more than ever, we need your support! Become a Supporting Subscriber today.
BBC America Clip from Doctor Who: The Eleventh Hour (SPOILERS) (video)
There is only one more week until the new season of Doctor Who starts on BBC America , Saturday, April 17th at 9/8c. Check out a new clip from the premiere (contains possible SPOILERS):
The Doctor Meets Amy


text:
Stockton police looking for suspect who shot 5
Sergio Hernandez released
Central California police are looking for the shooter responsible for killing two and wounding three others.
Stockton Police department spokesman Joe Silva said a gunman fired into an outside birthday party of about 20 people, including children, Sunday night before fleeing in a light-colored vehicle.
Police initially suspected 20-year-old Sergio Hernandez was the gunman. But Silva said Hernandez turned himself in to police Thursday and was released after an interview. Silva said Hernandez is no longer a suspect.
Police say Juan "Junior" Sarrarez and his girlfriend Reyna Perez were both killed in the shooting. The deaths were Stockton's fourth and fifth homicides of the year.
Copyright 2013 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
on January 21, 2013 - 8:25 PM
, updated January 22, 2013 at 12:59 AM
Lorraine Hughes wouldn't have missed it for the world.
"This is the place to be," said the 83-"and a half"-year-old Buffalo woman, who dabbed at her eyes with a tissue Monday as she stared admiringly at President Obama on a big-screen TV.
"This is such a wonderful thing to happen in my lifetime," she said of the Inauguration of the country's first African-American president for his second term.
Hughes was one of about 40 people, ranging in age from 6 to 92, mostly African-American, but some white, too, who gathered in the second-floor parish hall of St. Philip's Episcopal Church near Erie County Medical Center on Buffalo's East Side to mark the historic occasion.
Just as the church did four years ago when Obama first took the oath of office, St. Philip's held a community celebration to allow church members and others to share the moment together.
The Inauguration party took on extra significance for its participants because it took place on the day the nation was also observing Martin Luther King Jr.'s birthday.
"This is a day when we can claim the dream," said the Rev. Gloria E.E. Payne-Carter, the rector of the church, referring to the slain civil rights leader's famed "I Have a Dream" speech, which was recited to the crowd by a church member.
The program for the day at St. Philip's included morning prayers, a panel of young people talking about their hopes for the future and a celebration Mass in the sanctuary led by the Rev. R. William Franklin, the bishop of the Episcopal Diocese of Western New York.
Bruce Austin, of Buffalo, made sure to bring his three children – James, 10; Andrew,7; and Maria, 6 – to the St. Philip's event .
Andrew and his siblings sat quietly together in the front row as they gazed up at the screen to see Obama giving his Inauguration speech.
"It was great when he was talking," said the boy, who dreams of becoming a pilot when he grows up.
Roosevelt Samuel, of the Town of Tonawanda, said he was just as excited as he was the first time around when Obama took office – if not more so.
"Oh my gosh," said Samuel, who is 83. "It means a lot."
Lyne Westbrook, a home health care aide and author, said she came to her church to watch the inaugural festivities because she "wanted to have the feeling and the energy of everyone here."
The event was organized by Patrick Cray, a member of the church who is also a retired Buffalo police officer.
He was gratified to see the wide array of people who came to participate.
"I have a duty," he said, explaining why he wanted to be a part of the celebration. "It's my duty to be here."
email: email@example.com


text:
Serves 4 |
Prep Time 5 minutes |
Cook Time 5 minutes
2 cups red radishes, trim ends
2 cups water
2 Eden Umeboshi Plums, remove pits
1 tsp Eden Ume Plum Vinegar, or to taste
1 bunch red radish topsor turnip greens
3 Tbsp Eden Kuzu Root Starch, dissolved in 4 T. cold water
Place radishes, water, plums, and ume vinegar in a sauce pan. Cover, bring to a boil and simmer 4 to 5 minutes minutes. While the radishes are cooking, blanche the greens in boiling water for 2 minutes. Remove, rinse, drain, squeeze out the water with your hands and chop. Remove umeboshi plums and discard. Remove radishes and place in a serving dish. Add kuzu to the cooking liquid, stirring constantly until thick and translucent. Pour sauce over radishes and arrange the cooked greens in the center.
Eastern, Gluten-Free, Good/High Fiber, Japanese Food, Low Fat, Macrobiotic, No Sweetener Added, Side Dish, Vegan, Vinegars, Wheat-Free


text:
on January 17, 2013 - 3:32 PM
, updated January 17, 2013 at 3:40 PM
The Buffalo Public Schools got state approval for a teacher evaluation plan just in the nick of time Thursday, likely salvaging millions in state aid – while the Hamburg School District apparently forfeited $454,000 for its failure to submit a negotiated plan.
The president and vice president of the Hamburg Teachers Association met early Thursday evening with Superintendent Steven Achramovitch to discuss how to move forward in the absence of that state aid, according to someone in the union.
Hamburg was the only district in Western New York and one of only half a dozen in the state – including New York City – not to have an approved evaluation plan as of 8 p.m. Thursday.
Negotiations in Hamburg appeared to be on the brink of producing a successful agreement Tuesday when a district official told some teachers that their jobs would be lost if the district did not reach an agreement on evaluations. Union representatives pulled out of negotiations then, objecting to what they described as an implied threat.
Leaders of Hamburg's teachers union asked for help from the New York State United Teachers union at that point, sources said.
"We are encouraging both the district and the union to resume negotiations," NYSUT spokesman Carl Korn said at midday Thursday, but that did not happen.
Neither Achramovitch nor Hamburg Teachers Association President John Mrozek returned calls seeking comment.
Gov. Andrew M. Cuomo released a brief statement Thursday morning that appeared to remove any uncertainty over the possibility of an extension for Hamburg or any district.
"Today is the final deadline for the handful of school districts, including New York City, that have failed to get their teacher evaluation systems in place," he said. "Please hear me – there will be no extensions or exceptions."
At that point, he noted, 98 percent of the 700 or so districts in the state had approved evaluation plans.
"The remaining districts and their unions have until midnight tonight [Thursday] to do the same or they will forfeit the increase in education aid they have been counting on and both parties will have failed the children they serve," Cuomo said.
In Buffalo, district and union officials reached an agreement Tuesday night. State Education Department officials called them Wednesday morning with a number of adjustments that leaders from the union as well as the district described as minor.
The two sides submitted a revised plan at about 10 p.m. Wednesday and later learned it required further tweaks. Thursday afternoon – with less than nine hours to go before the midnight deadline – State Education Commissioner John B. King Jr. publicly announced his approval of a final version of the agreement, which was submitted that morning.
"The new evaluation plan is great news for Buffalo teachers, administrators, parents, and most important, Buffalo students," King said Thursday. "It's a strong step toward helping teachers and principals improve their practice, which will in turn help students improve their performance and build a better future.
"Our goal is to make sure every student graduates from high school ready to succeed in college or careers. Buffalo's evaluation plan is a major step toward helping Buffalo students reach that goal."
The agreement still faces approval by the Buffalo Teachers Federation's Council of Delegates, which will vote on it in March. Union President Philip Rumore briefed the council on the plan Thursday evening.
Rumore said he was pleased that the state had approved the plan – but he made it clear he was disgruntled with the entire process.
"The only thing I can say is that it shouldn't have been this hard and ultimately standardized tests and the [evaluation plan] have nothing to do with helping teachers teach and students learn, and actually works against it," he said. "I had to negotiate this, but I almost feel like I'm an accessory to a crime."
BTF members had mixed reactions to the state approval.
"I've heard opposition expressed to the idea of an [annual professional performance review] but no one has seen the document yet, so we'll have to see the provisions laid out in the document," said Mark Mecca, a school psychologist at Math, Science, Technology Prep.
Marc Bruno, who is considering running against Rumore for the union presidency this spring, said he wants teachers to have at least a month to review the agreement before any vote. Last year's plan contained mathematical errors in calculating teacher ratings, he said, because it was rushed through without having had adequate time for review.
Superintendent Pamela C. Brown said was pleased that the district met the deadline to salvage $33.4 million in state aid, and recoup millions in other that was threatened.
email: firstname.lastname@example.com


text:
Serves 8 |
Prep Time 10 minutes |
Cook Time 45 minutes
1 1/2 cups organic whole wheat pastry flour
1 pinch Eden Sea Salt
1/4 cup Eden Extra Virgin Olive Oil
1/2 cup Edensoy Originalor Edensoy Unsweetened
1 1/2 cups Eden Apple Juice
4 Tbsp Eden Kuzu Root Starch
5 cups fresh blueberriesor raspberries
To prepare the crust, mix the flour, sea salt and oil until the consistency of corn meal. Stir in the Edensoy and form into a ball. Divide dough in half. Roll into two flat pie crusts.
In a saucepan mix the kuzu with cool apple juice until dissolved. Place on low heat and stir until thick. Add fruit and stir. Place mixture over bottom crust in a pie plate, add and edge the top crust. Preheat the oven to 425° and bake 15 minutes; lower to 350° and bake 30 minutes more or until the crust is golden. Allow to cool before slicing.
Yields 1 pie; 2 crusts, 1 slice per person
American, Condiments, Dessert & Pastry, Edensoy, Fruit, Good/High Fiber, Japanese Food, Low Sodium, Macrobiotic, Oils, Whole Grain


text:
Top Definition
"Something something" means that whatever the person is talking about isn't worth clarifying.
"Why didn't you show up?"
"Something something work."
"Yeah..." -leaves-
"Something something work."
"Yeah..." -leaves-
Krammn가 작성 2015년 10월 19일 (월)
Trending Now
Can you define these popular missing words?
when you want to decirbe something which is really good.
we had the best dinner last nigth it was something something....
Eli가 작성 2005년 03월 15일 (화)
A common Israeli phrase meaning 'excellent', 'cool', 'extraordinary', 'awesome'
Adam: That chocoloate cake was something something.
Sam: You're so toned!
Sam: You're so toned!
Sam McGee가 작성 2006년 08월 12일 (토)


text:
Watch Featured Movies
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text:
Top Definition
Doing tags with paint rollers.
I had enought paint left so I started buff tagging over that toy's crappy tosses.
door DigDug 8 maart 2004
Trending Now
Can you define these popular missing words?
Doing tags with a fucking paint roller, usually a mini paint roller at that.
Buff tagging is gay and only for dumbasses who don't have can control.
door DaveJohnson@NewYokr 27 februari 2004


text:
Raptor Feeding at Leslie Nature Center- Ann Arbor
Saturdays, July 6, 13, 20, & 27
1:00-3:00 p.m.
All ages
Free Event
Drop by and see how feet and beak work together to help birds like the Red-tailed Hawk eat a rat or the Peregrine Falcon consume a quail. Volunteers will be feeding the birds and answering your questions — after watching the birds in action, you'll likely have quite a few! Please note: this is a free drop-in event. Please be aware birds may or may not be coming out of their enclosures to eat during feeding times, depending on the species and time of feeding.
The Leslie Science & Nature Center is a nonprofit organization that provides environmental education and experiences for children, families, and other individuals to honor and perpetuate the legacy of Dr. and Mrs. Eugene Leslie by fostering understanding, appreciation, stewardship, and respect for the natural world.
Leslie Science & Nature Center
1831 Traver Rd
Ann Arbor, MI 48105


text:
Tax advantages, account flexibility, and strong investment options are some of the benefits offered by the CollegeCounts 529 Fund. And with the assistance of an investment professional, setting up an account with CollegeCounts is easy.
The CollegeCounts 529 Fund Advisor Plan is a qualified tuition program under Section 529 of the Internal Revenue Code that is sponsored by the State of Alabama and administered by the Board of Trustees of the ACES Trust Fund (the "Trust" and plan issuer). Union Bank & Trust Company serves as Program Manager and Northern Trust Securities, Inc. acts as Distributor. Accounts and investments under the CollegeCounts 529 Fund Advisor Plan are not insured or guaranteed by the FDIC, the State of Alabama, the State Treasurer of Alabama, the Board, the Trust, the Program, Union Bank & Trust Company, Northern Trust Securities, Inc., or any other entity. Investment returns are not guaranteed and you could lose money by investing in the Plan.
An investor should consider the investment objectives, risks and charges and expenses associated with the Program before investing. This information is contained in the Program Disclosure Statement. Please read it carefully before investing.
If you are not an Alabama taxpayer, consider before investing whether your or the designated beneficiary's home state offers any state tax or other benefits that are only available for investments in such state's qualified tuition program.
Not FDIC Insured. No Bank Guarantee.May Lose Value.


text:
Student Affairs
Cortez Hall
Brownsville, TX 78520
Ph. 956-882-5134
Continuous Quality Improvement (CQI), also known as Institutional Effectiveness (IE) is the term used to describe the process of quality improvement followed by the Division of Student Affairs at UTB. "Quality Improvement, Total Quality Management, and Quality Assurance" are terms given to the processes many businesses undertake to produce increased efficiency and employee and customer satisfaction. Though the outcomes in an educational setting differ from those in the business world, efficiency and achievement of stated outcomes and objectives remain the foundation for the division's improvement process.
In addition to all mandates from external agencies and organizations that hold public education accountable for accomplishment of its mission, at the heart of true continuous quality improvement is the question of whether and to what extent colleges are producing more competent students. The CQI framework developed for the Division of Student Affairs is integrated and strongly linked to the decision-making process that leads to improved quality of programs and services, and the overall educational experience of all students.
The University of Texas at Brownsville website uses Javascript.
To access this page as it is meant to function please use a Javascript
enabled browser.


text:
More than 1,000 square feet? Check. Seven 60-inch, 3-D plasma TVs? Check. Two bathrooms, a kitchen with granite counter tops, a conference area? Check, check, check.
And the network will be writing some serious checks, too – $8,750 a week – to rent the palace-on-wheels for its new star, 33, who replaces Charlie Sheen on the top-rated sitcom, reports London's Daily Mail.
Courtesy Anderson Mobile Estates.com
If the rent seems exorbitant, check out the purchase price for one of these babies – upwards of $2 million.
Of course, if Kutcher grows fond of his new digs, he may be well positioned to spring for one. His salary for Two and a Half Men will reportedly approach $1 million per episode for 26 episodes.
Courtesy Anderson Mobile Estates.com


text:
Not only do I spent a lot of time reading books, but I spend a lot of time reading about books. I recently ran across Flavorwire's article 'The 30 Harshest Author-on-Author Insults In History [1]' and I have to admit that I laughed out loud. Collected here are real quotes from authors about authors - disparaging in a cruel but also often funny way.
My favorite? Truman Capote on Jack Kerouac - "That's not writing, that's typing." Ha!
Curious about the lives of authors or interested in more author zingers? Check out these interesting books about authors:
Fighting Words : Writers Lambast other Writers--from Aristotle to Anne Rice [2] edited by James Charlton
Once again to Zelda: the Stories Behind Literature's Most Intriguing Dedications [3] by Marlene Wagman-Geller
Remarkable Reads: 34 Writers and Their Adventures in Reading [4] by J. Peder Zane
Artistic License: Three centuries of Good Writing and Bad Behavior [5] by Brooke Allen
How I Write: the Secret Lives of Authors [6] edited by Dan Crowe with Philip Oltermann


text:
on October 3, 2012 - 8:31 PM
, updated October 4, 2012 at 8:40 PM
Any skeptic doubting just how important the congressional race between Chris Collins and Rep. Kathleen C. Hochul looms in national politics ought to check out the fundraising schedule for both campaigns over the next few days.
Some of the biggest names on the national stage are involved.
Incumbent Democrat Hochul, for example, heads to Manhattan today for an event benefiting her and select other New York congressional candidates. It will be headlined by none other than House Minority Leader Nancy Pelosi and former Vice President Al Gore.
Collins, the Republican challenger, is slated on Saturday to import House Speaker John A. Boehner to a fundraising breakfast for him and other New York candidates at Samuel's Grande Manor in Clarence. It will be followed by a get-out-the-vote rally at a Depew campaign headquarters partially funded by the speaker's political operation.
As the campaign heads into its final month, both sides are rolling out their big guns to replenish the millions of dollars already spent in a race intensely coveted by national Democrats and Republicans alike.
Erie County Republican Chairman Nicholas A. Langworthy said the fact that Boehner previously identified the Collins effort as a top Republican priority is now underscored by his Saturday visit here.
"To have the Speaker of the House come here in October when there is a lot of politics going on around the country shows just how important this seat is," he said.
On the Hochul side, sources with knowledge of the situation say the congresswoman will report raising about $730,000 this quarter – a staggering amount for an upstate congressional campaign.
While polls show Pelosi as unpopular in the overwhelmingly Republican 27th Congressional District, Langworthy observed he does not believe Hochul desires any local campaign efforts by the former speaker.
"Al Gore and Nancy Pelosi certainly do not represent Western New York values," he said.
Hochul spokesman Francis Thomas noted that today's New York City event benefits several Democratic candidates from around the state.
"I think Kathy has been very successful raising money on her own," he said. "It would be one thing if Nancy Pelosi were holding an event for Kathy Hochul, but it's for candidates all over the state."
Boehner, meanwhile, has made no effort to hide the national GOP's effort for Collins. He singled out the campaign and a few others in New York as top national priorities when he addressed the state delegation to the Republican National Convention as it met in Clearwater Beach, Fla., in late August.
He announced then his political operation would establish "victory centers" in key congressional races around the country to identify Republican voters and get them to the polls on Nov. 6.
He outlined a plan in which his National Republican Congressional Committee will assist in identifying and turning out voters in "orphan districts."
"I've got 53 orphan districts around America," he said then. "And, as a result … if we don't have a real ground game in each of those districts, we're going to get blown away.
"There about 10 victory centers operating in those congressional districts in New York," he added. "We identify voters, we register voters and, most important, get them out to the polls."
Boehner mentioned districts in Buffalo, Rochester, the North Country and eastern Long Island as his priorities.
Now, Langworthy said plans are translated into operations. The Collins campaign, the New York Republican State Committee and Boehner's troops are jointly funding the "victory center" serving as the Collins campaign headquarters at 6363 Transit Road, Depew. That's where Boehner and state GOP Chairman Edward F. Cox will stage a major get-out-the-vote rally for Collins at 9:45 a.m. on Saturday.
Boehner is no stranger to the area, often dropping by to assist Republican congressional candidates. He was last in Western New York in May 2011, when he starred at a fundraising luncheon for Republican congressional candidate Jane L. Corwin at Salvatore's Italian Gardens in Depew that drew about 300 supporters and raised approximately $150,000.
His latest appearance comes after a new anti-Hochul ad sponsored by the U.S. Chamber of Commerce that attacks her support of "Obamacare." The spot is slated to run in Rochester and Buffalo. Local sources estimate the buy at about $200,000.
The Chamber sponsored an earlier series of anti-Hochul ads in May.
email: firstname.lastname@example.com


text:
It looks as though energy efficiency is still a big priority
for municipalities and countries across the globe. We've already detailed energy-efficient LED
lighting efforts put forth by Raleigh, NC. We've also discussed how Australia and the European Union (EU)
plan to get rid of incandescent light bulbs by 2009. The United States is also
moving towards ushering out inefficient lighting with H.R. 1547, which was
published on March 15, 2007.
The bill (PDF),
which was submitted by California representative Jane Harman, indicates that
light bulbs which have an overall luminous efficacy of 60 lumens per watt
(lm/W) will be prohibited by January 1, 2012. The energy requirements get
progressively steeper every four years. On January 1, 2016, the requirement
will grow to 90 lm/W and will reach 120 lm/W by 2020.
A traditional 100W tungsten incandescent light has an
overall luminous efficacy of 17.5 lm/W. A 23W
compact fluorescent (100W equivalent) has an overall luminous efficacy of 60
Exemptions could be made by the Secretary of Energy for
certain applications where it wouldn't be feasible to use energy-efficient
lighting. These include applications related to military, medical or matters of
public safety.
If an exception is made by the Secretary of Energy, that
still doesn't give entitle the recipient to a free pass to continue using
outdated technology. The exemption will only be in effect for two years after
which the current enacted requirement will have to be adhered to.
The bill also notes that consumers and businesses will be
given incentives to encourage the use of energy efficient light bulbs.
quote: When DC shorts out the whole line lightes up like a lightbulb filiment. Causing fires in houses along the entire trail all the way back to the power source. Ever seen a car's DC wiring fry? You gotta replace the entire wiring harness or else use a butt load of electrical tape. When AC shorts out heat is only generated at the short.
quote: Generators generate AC electricity, you will loose half the generated amount of electricity when you convert it to DC. (Sine wave grounded at <0 vs. current flowing in the reverse direction <0)


text:
No longer in current production, content is subject to change and is provided here for reference purposes only.
- Laser Engraved Limited Edition
- Engraved Side Plate
- Unfluted Cylinder
Smith & Wesson L-Frame revolvers are built to suit the demands of the most serious firearms enthusiast. Available in six and seven shot cylinders, the L-Frame has a strong, durable frame and barrel built for continuous Magnum® usage. As police officers and hunters will attest, this firearm is made to withstand heavy use.


text:
Got an e-mail from Nintendo World that they will be selling the Wii U on a first come, first serve basis with a whole bunch of other goodies.
I knew it.
Looks like all the shipments that WERE going to Amazon will be at the Nintendo World Store. I can't imagine anyone on line NOT going a Wii U.
I lived in NJ during Wii launch and got my Wii from Nintendo World prior to Christmas however I had to show up at midnight and wait for the store to open. There were lines for months. Same deal w/ Wii Fit which was hard to find for a very brief period.


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UNIVERSITY PARK - Zach Zwinak really does play smash-mouth football, and somewhere out in the world is a crushed face mask to prove it.
Zwinak ran over countless defenders last season on his way to 1,000 yards and an average of 4.9 yards per carry. Almost impossible to stop in his tracks when he builds up a head of steam, Zwinak was such a big surprise for Penn State in 2012 that he actually made the college coach of the year look bad.
"Judging by the fact that I had him as the third- or fourth-team running back at the beginning of the year, I would say that that's some bad coaching," PSU's Bill O'Brien said, "because I think in about, whatever it was, 8 1/2 games, he gained 1,000 yards."
Article Photos
Mirror photo by Patrick Waksmunski
Penn State running back Zach Zwinak carries the ball during a drill with Deron Thompson.
Or, put another way, 95 more yards than former Nittany Lion running back Silas Redd gained at USC.
The quintessential Zwinak moment wasn't widely known until Tuesday, when linebacker Glenn Carson shared an intriguing story from last year.
The equipment manager of one opponent - no one seems to remember which team it was - sent a picture of a safety's face mask that had been caved in when Zwinak hit him.
"I have seen the picture but I don't really remember it," Zwinak, who seems to hate talking about himself or his impressive 2012 season, said during a teleconference Wednesday.
Penn State has numerous weapons on offense, but when all is said and done, Zwinak could turn out to be the biggest asset for a team with a young, unproven quarterback.
As the old saying goes, two of the three things that can happen when you throw the football are bad. Hand it off to Zwinak, on the other hand, and the outcome is pretty much guaranteed for the Lions.
He's going to pick up positive yardage.
"He's a load," Carson said. "He's a big guy, he runs behind his pads and he's definitely a tough, physical player."
Asked to explain what it means to run behind his pads, Carson added, "He's not afraid to put his shoulder pads down, his helmet down and try to run someone over."
That's the best safety valve possible for quarterbacks Christian Hackenberg and Tyler Ferguson. There are others on the team, of course, such as talented tight ends and receivers, but having a brute, forward-churning tailback provides a great option for a young quarterback.
Zwinak carried the ball 203 times last season, and in all of those, he only lost 7 yards.
Trying to arm tackle him is useless, and his ability to escape would-be tacklers time after time starts to wear on them.
"That can deflate a defense if you miss a tackle," PSU defensive tackle DaQuan Jones said of Zwinak's ability to keep driving forward.
College football doesn't keep a stat on yards after contact, and Zwinak didn't bother guessing how many he had when asked. But it was certainly a lot.
"It's always falling forward," he said. "If you're going to go down, go down forward, never fall back."
Zwinak loves contact. And he seeks it out.
Even when he was wearing a red no-contact jersey early on in training camp - from a left wrist injury suffered during the spring - he would go looking for defenders to hit. They couldn't hit him back, which they thought was unfair, so O'Brien removed the red jersey.
"Zach's a tough guy," O'Brien said. "I love coaching Zach. He's very hard on himself. He demands perfection of himself. He's tough, he's a big guy, he can run, he's got deceptive speed, and you know, he can catch the ball."
Zwinak had 20 catches for 177 yards last season, making him the kind of dual threat that the quarterbacks will love even more.
The only negative to Zwinak's 2012 season was that he fumbled five times. For a perfectionist, as Zwinak readily admitted he is, that had to eat away at him.
"We work ball security every single day," he said of practice. "It's one of the most important things as a running back. Coach [Charles] London has a bunch of different drills that we do, and it involves somebody hitting on you and wrestling the ball away from you."
If Zwinak can correct the fumble-itis and continue to bulldoze over defenders, it will give Penn State's quarterbacks extra confidence to know that they don't have to do it all on offense.
Zwinak also has backups Bill Belton and Akeel Lynch to take some of the carries - and pressure - from him, keeping him fresher for big carries in late-game situations. That should make him even tougher to bring down.
"He's a great running back," guard Miles Dieffenbach said, "and he really helps you out breaking all those tackles and breaking through the arm tackles."


text:
It's good to be back in swing
Now where were we before we were so rudely interrupted? We had quite an experience starting Jan. 2 when we fell and broke a hip. Surgery by Dr. Tom Fessler followed and then a 60-day convalescence at St. Mary's West. It was good to finally return home, and we are now getting back to the way it was. ... We enjoyed seeing friends like John McLaughlin, Bob Brabender, Joe Cyterski, Jim Cox and others who reside at St. Mary's. The care is first-rate there and, because the place is nice and warm, we did not miss being outside in Erie's freezing cold and snow. Many nursing homes even allow your dog to visit. ... One thing we missed in recent weeks was the opportunity to pay our last respects to friends who died. We would have ordinarily done this. Sadly, too many friends passed since the first of the year. ... Don't forget that daylight saving time starts today. Everyone should have set their clocks ahead by an hour. ... We have watched a lot of college basketball, and the NCAA men's tournament, set to start March 21, should be wide open. We recall that the late Ben Wiley, who had been an excellent player at Gannon in the 1960s, used to take the week off to watch all of the tournament games. When Michigan's men's team plays on TV, which has been often in recent days, the Wolverines' coach, John Beilein, has been a familiar face. Back when Tom Chapman coached at Gannon, LeMoyne College was also a member of the same conference. Beilein coached LeMoyne at that time, and the team's star guard was Dave Niland, Beilein's brother-in-law, who is now the highly successful men's basketball coach at Penn State Behrend.
People of Irish descent and those who just like to celebrate St. Patrick's Day are starting to gear up for the big day on March 17. This year's class of the Knights and Ladies of St. Patrick includes Tim Fuhrman, Carol Kuzma, Pat Liebel, Meg Loncharic and John Maloney. ... The Haener Brothers Irish Band will give a free concert Friday at 1 p.m. at the Pennsylvania Soldiers' & Sailors' Home. Fred Haener said Irish jigs, waltzes and folk music will be featured. ... When several former Notre Dame football players appeared at Art Arkelian's banquet, they autographed a football that Erie Insurance CEO Terry Cavanaugh won with a bid of $800. Then he donated the ball to the local Notre Dame alumni group that will have its big annual dinner Thursday at the Kahkwa Club. The ball will be auctioned at the dinner.


text:
At the beginning of Thursday's American Idol, there were 43 men left in the competition. The next hour was a bloodbath, with many tears and a few tantrums – as well as some standout performances. Curtis Finch Jr., for example, performed a version of Christina Perri's "Jar Of Hearts" that was arguably the strongest of the evening. It may be the season's most overdone song, yet Finch successfully infused it with a rising gospel vibe.
Like every reality show, the contestants learned valuable life lessons as they fought to stay in the game. Here are five:
1. Never Let Them See You Sweat
Paul Jolley looked like he was going to throw up when he took the stage. "I'm so nervous," he said as he fought back tears. The judges watched quietly as he pulled himself together and gave a strong performance of Carrie Underwood's "Blown Away." He advanced, but not before Nicki Minaj criticized him for showing his nerves. "You walked out so defeated and that really irritated me," she said. "Just give us one minute of professionalism."
2. Be Funny and Unexpected
Admit it: It was kind of funny watching Gurpreet Singh Sarin nail "Georgia On My Mind." The judges liked him, perhaps because he doesn't fit any mold. Neither does Charlie Askew, who worked his quirky awkwardness into an intriguing version of Gotye's "Somebody that I Used To Know," complete with a spoken-word intro. "I am obsessed with you," Minaj said, prompting Askew to respond, "Baby, I could say the same thing." She ate it up.
3. Too Much of A Good Thing Can Be Lethal
Matheus Fernandes, one of the standouts from the Los Angeles auditions, was eliminated after a shaky rendition of Kelly Clarkson's "Stronger." The 4'9" contestant made one too many self-depreciating comments about his height, prompting Minaj to say, "Sometimes things can go from being inspiring to becoming you wanting a pity party." When Carey called him a "good person," his face said it all – Fernandes knew he wouldn't be advancing to the next round. In contrast, Lazaro Arbos said nary a word about his stutter, yet he advanced easily, despite an unspectacular rendition of Lady Gaga's "Edge of Glory."
4. If You Lose, Lose Gracefully
The night's "Sour Grapes Award" goes to Papa Peachez, who performed a karaoke-worthy version of Gaga's "Yoü and I." Minaj was unimpressed. "I'm so disappointed," she said. "I don't know why you chose that song." After he was eliminated, Peachez decided he didn't want to win American Idol, after all. "This isn't the competition for me," he said. "I just don't like singing other people's songs."
5. Big Risks Can Reap Big Rewards
Nick Boddington was eliminated in Las Vegas last season, so he came back determined to take some risks. He accompanied himself on the piano while singing Grace Potter's "Stars." It was a strong performance that the judges loved.
After the dust settled, 28 contestants remained. The judges corralled them onto the stage and announced that they would eliminate eight more male contestants next week, after the ladies' auditions.
American Idol: Early Favorites Eliminated in Hollywood
Michael Becker/FOX.
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How is Microsoft Relevant to Developers?
- Posted: Jul 14, 2011 at 2:31AM
- 1 comment
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Wilbour Craddock's (Architect Evangelist, Microsoft Ireland) keynote at reMIX Dublin for developers. Wilbour discusses some of the emerging trends from a development and information consumption perspective - including: 'three screens & the cloud', IE9 & html5, Kinect & 'natural UI', Surface, slates, and other multi-touch devices.
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Scrapbook MAX! Digital Scrapbooking Software
Archival Quality Digital Scrapbooking Software
2 new layouts... Just want to illustrate that the kit allows to make layouts with different styles...
KapiScrap ScrapbookMAX store
Very Cute!
Be Happy
Thanks MarthaT!!!!
Here is another layout with this kit:
Here's a few I did with Sandrine's kit...great kit Sandrine!
Awesome kit and layouts!
Many thanks for showing me your nice layouts. That makes me happy.
SBM Diane,
Thanks for your nice comment.
and another
Wow! Letha! Really great! I love it.
A new layout... made today...
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Forum Rules


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Selena Gomez, Justin Bieber and Ashley Tisdale are all featured in a new music video for Carly Rae Jepsen's "Call Me Maybe". The music video isn't an official released by Jepsen's team. The description states "Hey guys! Here's the music video I promised featuringall my friends to Carly Rae Jepsen's song 'Call Me Maybe'. Make your own video with your friends and post it here!" The video was uploaded by CarlosPenaTV.
The video has already received over a million views since it was announced today that Bieber and Gomez both are featured in the video. Fan comments are coming on YouTube in five second intervals.


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Investigators returned to the scene Friday of a crash that killed a motorcyclist in Reading earlier this week.
Members of the Berks County district attorney's forensics investigation unit took detailed measurements of the scene in the 1000 block of Penn Street.
Daniel Felix was driving an off-road motorcycle erratically when officers tried to stop him Sunday afternoon, police said.
Felix, 29, of Reading, kept going until the bike struck a vehicle and a curb near 11th and Penn streets. He died at the scene.
Police Chief Bill Heim told 69 News that Friday's work was a routine part of the ongoing investigation.
He also said Monday that the city has seen an increased use of the illegal bikes on the streets over the past few years.


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Description & Highlights
DCS Caster Kit
The DCS (UC) Caster Kit will add an extra level of portability and convenience to your DCS professional kitchen appliances. Use with the DCS Outdoor Refrigerator (RF24R) and enjoy cold drinks by the pool, then wheel to the patio for snacks an arm's reach away!
Compatibility:Use with DCS products RF15I, RF24D, RF24R and RF24T
- Model: UCDCS Caster Kit
- Brand: DCSAllows freestanding use & portability of DCS appliances
- Set of four (4) castersStainless steel and rubber
- Warranty: 1 year limitedCompatible with RF15I, RF24R, RF24D & RF24T models


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Top Definition
A formidable foe to normal people. intelligent, strong forceful. a weird hybrid of a bully and a nerd. As well as the first dictator of the America and king of the new peaceful world. Also known as Timebomb and various other variations including at least TB.
I am David. All other David's fall in march as we conquer the world. For a new Earth of peace void of general stupidity.
by TkTb November 19, 2006
Trending Now
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Photos & Videos
a very hot guy usually nice and very funny
dude he is such a david
by lalalalallaall December 11, 2007
A person who is hecka cool or awesome. Everyone else is nothing compared to a David.
Person 1: You are really really cool, just like a David.
Person 2: Thanks! That really cheers me up.
Person 2: Thanks! That really cheers me up.
by Tommy Kirk January 02, 2008
One who is a BAD ASS MOTHA FUCKA. This person is often very good looking and usually quite daring. This person also enjoys a nice glass of scotch, and most closely compared to the badass McLovin.
"You are such a David for banging my mom and sister!"
"Only David could have raped Goliath."
"Only David could have raped Goliath."
by bamafan135 January 10, 2008
A man who is above all men. He reads the Urban Dictionary definitions and laughs at them. Some are accurate, some are not. Davids exude confidence. Qualities to look for in a David are tallness, excellent brown hair, sweetness, loves high fives, nerdiness, Marvel Comics titles (Spectacular, Amazing, Astonishing, etc.). A David can laugh in the face of danger. A David has his zombie survival plan all worked out and he knows who he's saving. Davids are generally kind to all who encounter them, but can be protective and territorial. Evildoers beware, because there just might be a David right behind you.
David drives 60 miles down the highway. Tim drives 60 miles down the highway going in the opposite direction. They meet and high-five. To keep the universe balanced a hole is torn to the peanut butter dimension and there is an explosion of peanut buttery epicness.
by TheKarmaMan December 10, 2010
david is... the most amazing person you will ever meet..he is kind and sensitive..strong and daring..and he is gentle and sweet... he might not always think befor he does something..but thats what makes him so amazing..he is very very good looking..and oh he is a great kisser..if you meet this david..you should never ever let him go..cause if you do you might not get him back..
i love david.
i love david.
David you are amazing.
by khopp<3 October 19, 2009
Sexiest man alive; knows how to cheer a girl up when they are having a bad day; can make you laugh at everything; serious but also can be wild and crazy; always wants what is best for the people he cares about most; gets along with almost everyone; is not afraid to be himself; is the sweetest man you will ever meet, you'll love him to pieces as soon as you meet him.
He's a David
by SusieMcGiggleBriches February 22, 2010


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Top Definition
Where a substantial amount of weight is lost due to the appetite being suppressed when smoking rock (methamphetamine).
"Spent $2k on rock last week and lost 8kg. Haha can't remember the last time I ate or slept either. Rock diet for life!"
ayon kay Midnight Tweaker ika-20 ng Pebrero, 2006
Trending Now
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The Indianapolis Motor Speedway hosts its first auto race, The Beatles kick off their first American concert tour, Groucho Marx dies, Mike Tyson returns to the ring, and the last U.S. combat brigade leaves Iraq, all on this day.
Full CoverageBreaking News
On this day: August 19UPDATED 1:00 AM CDT Aug 19, 2016
Slideshow Central
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Educational Background
- B.S. in Psychology, Centre College
- M.S. in Educational Psychology, Indiana University
- Ph.D. in School Psychology, Indiana University
Research Interests
- Educational psychology
- Counseling techniques
- Advanced tests and measurement
- Applied behavioral psychology
- Educational Psychology
- Counseling Techniques
- Applied Behavioral Psychology
- Advanced Tests and Measurement
Selected Publications
Meyer, L. D., Anderson, J. A., & Huberty, T. J. (2008). School involvement in the Dawn Project: Outcomes for youth with emotional and behavioral difficulties from ethnically diverse backgrounds. Multiple Voices.
Anderson, J. A., Meyer, L. D., & Somers, J. W. (2006). The Impact of System of Care Participation on School Functioning: Exploring Caregiver and Teacher Perspectives. Preventing School Failure, 50 (3), 13-20.
Meyer, L.D. & Anderson, J.A. (2005, September). School Involvement and the Restrictiveness of School Placements Over Time. Research briefing in the Indiana Consortium for Mental Health Services Research / Dawn Project Evaluation Study Public Briefing publication.
Skiba, R. J., Knesting, K., & Bush, L. D. (2002). Culturally Competent Assessment: More than Nonbiased Tests. Journal of Child and Family Studies, 11 (1), 61-78.


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Top Definition
Someone that is particularly wimpy or someone that lets an opportune moment slip by to pick up/score with a potential mate
C'mon mate don't be such a pusscat! Give her a shag anyway, who cares if she's packin' a massive donger!!
от Gringo87 19 януари 2014
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Download the WOT add-on
WOT shows you which websites you can trust based on millions of users' experiences around the world to help you stay safe when you search, surf, and shop online.
- Traffic light style icons guide you find trustworthy links on search engine results, social media, online email, and many popular sites
- You can leave your own ratings to help other web users stay safe
- Third-party trusted sources provide technical security
- It's fast, free, and easy-to-use
- Interested to know how the WOT system works? Learn more here.
System requirements
- Operating system
- Windows (all)
- Mac OS X
- Linux
- Mozilla Firefox 14 or later
- Version history
- Operating system
- Windows (XP or later)
- Mac OS X
- Linux
- Chrome 18 or later
- Version history
- Operating system
- Windows 7
- Windows Vista
- Windows XP
- Windows 2000
- Microsoft Internet Explorer 6 or later (9 recommended)
Version history
- Version history for IE add-on (current version Not available)
- Operating system
- Mac OS X
- Windows (XP or later)
- Browser
- Safari 5.1 or later
- Version history
- Operating system
- Mac OS X
- Windows (XP or later)
- Linux
- Browser
- Opera 12 or later
- Version history
The WOT bookmarklet brings some of WOT's functionality to other browsers. Add the WOT bookmarklet to your browser simply by dragging this link to your bookmarks.
Using the bookmarklet is simple: click the bookmark and it will display a WOT popup on the page, showing ratings for the current site. Another click will hide the popup. This gives you an easy way of accessing WOT reputation data, although you won't be able to give your own ratings.
Another great tool to help you avoid clickjacking is Web of Trust (WOT). WOT is a free browser tool that maintains a database of known safe sites as well as malicious sites reported by the WOT community. Attempts to visit a known malicious site and WOT warns you in advance. The WOT download is simple to install; just visit www.mywot.com.A Guide to Facebook Security - For Young Adults, Parents, and Educators Read Facebook's Security Guide in PDF format
The Web becomes more dangerous every day. Malware has become ubiquitous, scam sites proliferate, and there are constant privacy dangers. What to do? Try WOT (Web of Trust), an excellent--and free--browser add-on that offers protection.Preston Gralla Read more at PCWorld
There are other websites dedicated to peer reviews of other websites, but none so well-integrated into web-browsing as Web of Trust. A tool such as this is truly useful only if it is easy to access, and Web of Trust fills that void admirably.GeekDad Read more at GeekDad, wired.com
WOT will help you avoid bad sites altogether. The Firefox add-on allows users to rate sites. Those ratings are shown on most popular search engines. Results feature a green, yellow or red icon. Stay away from red sites."Kim Komando Read more at Komando.com, website for The Kim Komando Radio Show®
Your browser of choice may have changed a lot in the past year, but luckily the best extensions for making your browser better have kept up with all the most popular browsers. — WOT can provide you with ratings from other WOT users. This is especially useful for online shopping."Adam Dachis Read more at Lifehacker
WOT provides interesting features that allow worldwide users to rate Web sites for danger, thus creating an online community of like-minded people.CNET staff Read more at CNET's download.com
WOT is Editor's Choice because it leads in many areas: compatibility and integration with seamless operation; flexible options; searching; warning and blocking; and user input.Rizar Read more at Gizmo's Freeware
…unobtrusive yet amazingly useful extension shows a rating icon next to each site in search results from Google, Yahoo, Wikipedia, and other popular Web services.Becky Waring Read more at Windows Secrets
WOT rates search results, which is a nice feature. You have an idea before you proceed to the Web site.Michael Kassner Read more at Tech Republic's 10 Things
The innovative concept and well-engineered ranking system makes Web of Trust an important security enhancement and an essential extension for your browser.Chrome-plugins.org Read more on Chrome-plugins.org


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BELOIT, Wis. — Award-winning documentary film "Lion Ark" will play on three different days during the Beloit Film Festival.
The showings are 5 p.m. Feb 21 at My Apartment, 429 E. Grand Ave.; 5 p.m. Feb 22 at Cafe Fromage #1, 431 E. Grand Ave.; and noon Feb. 23 at Hendricks Center for the Arts, 409 Pleasant St.
Admission: $8, adult; $5, students. Student tickets are not available online. For information: lionarkthemovie.com
Location, ST | website.com