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By YESENIA AMARO
A Merced nonprofit is working to make sure that eligible Hmong children and their families enroll for benefits in the Patient Protection and Affordable Care Act.
The Healthy House Within a MATCH Coalition has two grants to help enroll at least 700 eligible Hmong children and adults for health insurance coverage under the law, said Candice Adam-Medefind, executive director for the nonprofit.
As part of the grants, Healthy House also will work on policy issues, develop culturally and language responsive materials about the law and play an advocacy role in making sure Merced County implements the law effectively and efficiently, she said. "To keep the voice of the ethnic community in the debate," she said.
One of the grants is from PICO California (People Improving Communities through Organizing), a faith-based organization that helps to address problems and concerns in communities, according to its website. The second grant is from the Building Resources, Insuring Growth for a Healthy Tomorrow Project.
Healthy House joined with PICO California, organizations in the Hmong Health Collaborative and the Southeast Asia Resource Action Agency in Sacramento to implement the grants.
The nonprofit surveyed 106 Hmong families in Merced to get a sense of how many children and adults are uninsured.
The results indicated that 15 percent of the families had uninsured children under the age of 18, Adam-Medefind said, and 53 percent had uninsured adults.
Nearly 60 percent of the families said they would like help to apply for health insurance coverage through the Low Income Health Program.
The program is being established in counties across the state to extend coverage.
Merced County is one of 10 counties in the state that isn't far into the process of implementing the program, Adam-Medefind said.
Healthy House has requested a meeting with officials from the Merced County Department of Public Health to see where they are with the implementation and how the nonprofit can help.
There are several barriers explaining why families are uninsured, said Adam-Medefind. They include economic, language, lack of knowledge and institutional barriers.
Palee Moua, director of cultural services at Healthy House, said she's interviewing local families to find out what their personal barriers are to being uninsured or having uninsured children. She will present the local stories of families next week in Fresno at a news conference.
The cost of care can be so high that some of the uninsured choose to forgo a visit to the doctor when they're sick, Moua said.Merced County has about 2,000 children who are eligible for Medi-Cal or Healthy Families, an insurance program for people with low incomes, but they're not enrolled, Adam-Medefind said. About 79 percent of them are Latino children.
Adam-Medefind said she's glad to be doing this work, especially because the Central Valley is one of the most ethnically diverse areas in the nation. It's critical that community-based organizations get involved to make sure that the cultural groups in the Central Valley are enrolled, she said. "This is a chance for us to build a more equitable society," she said.
Moua said she wished they also had "funding to educate the community to understand how to advocate for themselves."
A study recently released indicated that more than 100,000 people in the state probably will miss out on the benefits from the Affordable Care Act because of language barriers.
Read more here: http://www.mercedsunstar.com/2012/03/10/2263447/merced-nonprofit-aims-to-ensure.html#storylink=cpy#storylink=cpy
Children with health insurance learn better - for instance, children
covered by Healthy Families showed 63% improvement in paying attention and keeping up with
school activities over their previous performance when
uninsured. read more


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Top Definition
The face one makes when orgasming. Making an O shape with ones mouth and saying Oh repetitively while thrusting ones pelvis to signify climax
I'm gunna show her my Oh face after the party, Oh Oh!
Refer to the 'Office Space' movie
Refer to the 'Office Space' movie
ayon kay McLean Nolan ika-21 ng Hunyo, 2006
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Can you define these popular missing words?

subset: commoncrawl


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Professional Courses in Accountancy and Finance
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Celebrity Central / Top 25 Celebs
Heidi Montag
- 2004
BFF Beginnings
After graduating high school, Colorado-native Heidi Montag heads to California to crack the books at the Academy of Art University in San Francisco. At a freshman orientation, she meets Lauren Conrad, star of MTV's hit reality show, Laguna Beach. "Everyone in the room was kind of gothy, and we were the two blond girls in the room scared out of our minds," Montag recalls to the New York Times in 2006. "I ran up to her and said, 'Will you please talk to me.'" Soon after, the new friends plot their move to L.A. to study at the Fashion Institute of Design and Merchandising.
- 2006
The Hills Are Alive...
MTV develops a spinoff with Conrad called The Hills, featuring Conrad's move to L.A. as she studies fashion, interns at Teen Vogue, and lives with Montag. (From left, costar Audrina Patridge, fellow intern Whitney Port and Conrad). Creator Adam DiVello tells PEOPLE, "It's really about the next stage in life, when you leave high school and leave home for the first time." In the first season, Montag drops out of FIDM to work for the event-planning firm, Bolthouse Productions.
- 2007
Spencer + Heidi = Speidi
During the second season of the hit show, tension surfaces between Montag and Conrad when Montag begins dating instigating bad boy, Spencer Pratt. Montag eventually moves in with Pratt, ignoring Conrad's warning of his wandering eye and her prediction that it will ruin their friendship. Conrad is also hurt when the couple urges her friend, Jen Bunney, to hook up with her ex, Brody Jenner. "I ... felt so betrayed," Conrad tells Montag.
Heidi Goes Under the Knife
Montag gets a nose job and breast augmentation, taking her bust size from an A-cup to a voluptuous 32C. "It was really something that had been tormenting me and I was very insecure about it," she tells Access Hollywood of her pre-surgery looks. "I thought about it for several years and I waited until I had the finances and really thought about it and was old enough to really make a mature decision."
Speidi Plants Sex Tape Rumors
Word spreads that Conrad made a sex tape with ex-boyfriend, Jason Wahler, but they both adamantly deny the rumors. And Conrad soon predicts that Montag and Pratt started the sex tape rumor. Pratt posts vulgar comments about Conrad on his Web site: "It's sad that she destroyed the sex tape...[It] would have made her real famous."
A Feuding Premiere
"You know what you did!" Conrad repeatedly screams at Montag during a confrontation captured in the third season premiere of The Hills. Conrad calls Montag "sad," while Conrad's new roommate Audrina Patridge calls Montag "brainwashed" by Pratt, who has been bad-mouthing Conrad in the press. Although many question the show's authenticity, the LC-Speidi feud helps drive ratings, drawing in 3.6 million viewers and making the premiere the highest rated show for MTV this year.
CosmoGIRL! Backlash!
Although Pratt tells EW, "We would get engaged; we just wouldn't do it on Lauren's show," he does just that. Around that time, Montag appears on CosmoGIRL!, but readers of the teen mag question editors' judgment. They call Montag "plastic and fake" and say she "trashed her best friend." An editor responds, "I just wish everyone would cut Heidi a little slack. Just imagine if you and your best friend got into some huge fight, and for whatever reason, you were never allowed to tell your side of the story, but your friend could, and everyone believed her."
- 2008
Heidi Does Maxim
With her new look, Montag appears on the cover of Maxim, where she says, "[Lauren's] changed. Some people go more Hollywood than others...I've heard from other people that she's a big diva now." Of their so-called reality show, Montag explains that it's "22 minutes" that's "edited for drama...They're not with us all the time, although I wish they were, because it would be a way crazier show. Let's see how Lauren would look then!"
The Infamous Music Video
Attempting to breakthrough as a singer, Montag releases her music video, "Higher," which receives an almost unanimously negative reception by PEOPLE.com readers. Directed by her faithful Pratt and featuring a bikini-clad Montag romping across a beach, the underperforming video is shot in 30 minutes, independently, for "zero dollars." "All negative energy," Montag tells PEOPLE. "I completely ignore it."
Reuniting for Rolling Stone
Montag, 21, and Conrad, 22, appear together – with Audrina Patridge, 22, and Whitney Port, 23 – on the cover of Rolling Stone. The shoot is the first time the two frenemies have been photographed together since their ratings-boosting feud. The magazine calls The Hills – which an MTV exec calls "the most influential show we've ever had" – "a maddeningly addictive TV show in which nothing ever really happens." "Who were Paris and Nicole before they weren't friends? That's when they became superstars," Montag's Pratt says. "If Lauren and Heidi were friends, people wouldn't tune in."
Photo Credits
BIOGRAPHY (top to bottom): Alexandra Wyman/WireImage; MTV; Matt Sayles/AP, Katy Winn/Getty; Jean-Paul Aussenard/WireImage; James Breeden/PacificCoastNews; Courtesy of Rolling Stone
- Name
- Heidi Montag
- Date of Birth
- September 15, 1986
- Birth Place
- Crested Butte, Colo.
- Relationships
Spencer Pratt, husband (2006 to present, off and on)
Jordan Eubanks, ex-boyfriend (2005 to 2006)


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Family Alliance for Veterans of America (FAVA), located in Forest City at the corner of Clark Street and J Street, is seeking interns!
FAVA would like to receive applications from students in the following majors: Business, Communications, Criminal Justice, Education, Foundations of Education, History, Organizational Leadership, Psychology and Wellness. Students interested in grant writing internships should also apply.
Interns should possess excellent verbal and written communication skills.
Interns must be able to maintain confidentiality of information.
Internships are unpaid.
Work hours: to be determined. FAVA office is open Monday – Friday 9am-5pm.
FAVA prefers interns that are veterans or who have had someone in their family serve in the military – even a grandparent or great grandparent. However, FAVA will consider all candidates.
To apply, forward your resume and cover letter to:
Rhonda Jordal, Director
Family Alliance for Veterans of America (FAVA)
100 North Clark Street, Forest City, IA 50436
Or by email:
What exactly is FAVA? From FAVA's website --- www.fava.westcare.com
FAVA provides information, education, advocacy and support to families of veterans and veterans across America at a time of their critical need. Such need arises, for example, when veterans return from combat with Post Traumatic Stress Disorder (PTSD) and/or Traumatic Brain Injury (TBI); when veterans and their families need assistance in getting help from the VA; when veterans suffer from addictions to drugs or alcohol; when veterans have encountered the criminal justice system, including incarceration; when veterans have attempted, or committed, suicide; in short, when veterans and their families are suffering in any way from service-related issues and problems. Focused assistance to veterans and especially, their families is FAVA's prime objective.
Contact the Career Center (lower level Salveson Hall) at 641-585-8681 or firstname.lastname@example.com for assistance in developing your resume and cover letter so you can apply for these internships! We can also help you prepare for your interview!
For more information: Waldorf University is a four-year liberal arts college offering 20 bachelor degree programs in a variety of popular fields both residential and online. For over a century, Waldorf has provided a signature student experience through an engaging community of learning and faith. That community has now expanded beyond the campus through Waldorf's distinct approach to online education. Waldorf's academic programs combine a strong liberal arts base with applied learning. Co-curricular programs ranging from the second oldest a capella choir in the nation, to an outstanding theatre program, to highly competitive athletic teams, provide students with a wide range of opportunities for meaningful participation in personal development. Waldorf is committed to engaging its students in service and in bringing the world to its students through international student recruitment and study-abroad programs. Every student is challenged to excel in Waldorf's community where students are treated with dignity and respect. The university has an attractive campus with 14 major buildings and excellent resources.
Copyright © 2016 Waldorf University | Forest City, Iowa 50436 800.292.1903 (Residential Programs) | 877.267.2157 (Online Programs)
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Wednesday, November 27, 2013
Doty Park was host to around 30 people Saturday night as residents of the immediate area, known as Brownsville, met with town and school district officials to discuss the upcoming construction of Dorchester District 2 Elementary School 3.
The school is set to be built on the Alston Middle School campus, located off Hwy 78, and will be ready for students in 2015.
Shortly after the construction was announced in September, Town Councilman Aaron Brown called a meeting for concerned parties to discuss the upcoming changes. Key members of school district leadership were invited, including Superintendent of Schools Joe Pye. While some members of the community were asked to attend, most were unaware of the meeting, according to Earnest Walker, a Brownsville community member who was invited. He said Councilman Brown hosted a second meeting shortly after.
"I asked my neighbors if they knew anything about the new school and the ball fields, and to be honest 99 percent didn't know anything about it. [The officials] said there would be another meeting, they sent me another letter, and I figured the community was going to be notified but I went to that meeting and only five of the actual community people were there," he said.
To get the community input officials said they wanted, Walker decided to organize Saturday's community meeting. He worked with the Community Resource Center and local churches to plan the event and invite community members to attend. Around 25 residents were there.
Also in attendance was Councilman Brown, Dorchester District 2 School Board Vice Chair Charlie Stoudenmire and the district Capital Improvements Facilitator Bob Folkman. Brownsville resident Bernie Mazyck served as the moderator.
"The school is probably the first and largest investment – both economical and physical – in the neighborhood for a long time," Mazyck said. "It's a significant asset our community will be participating in, so we though it'd be good for the community, the school district and the Town to have a conversation."
Folkman led the meeting, giving a presentation on the 19.42 acre construction of the new elementary school, which will serve 960 students.
The construction is one of four new schools and 13 renovation projects the district is undertaking in its $186 million budget.
Elementary School 3 is being built to eliminate overcrowding problems, Folkman said, so the district has plans to build it as quickly as possible. To do that they're using land the district already owns and a one-story architectural design.
He said the school will be complete and ready for use by August 2015.
"It will be a major improvement to that area," Folkman said. "It's a great focal point for this community."
In order to complete the construction quickly, the new school will be built where the Alston baseball and softball fields currently are. During the construction the fields will be temporarily relocated behind Spann and Summerville Elementary Schools, Folkman said.
The crowd became uneasy, however, when he began discussing the proposed plan to put the ball fields back on the Alston campus.
"How will those ball fields benefit the community?" Walker asked.
"I see the community involvements in those ball fields and I'm doing everything I can to put the ball fields back into the community," Folkman replied.
The designs he showed attendees featured one option for field replacement: between the rear of Alston, where the fields currently are, and Boone Street, property he said the district is trying to purchase.
He barely finished the presentation when residents began voicing complaints, concerns and worries about the plan. Their collective opinions were not in favor of the new ball fields.
Most of the concerns addressed light pollution, noise and late hours. The proposed site for the new fields would be incredibly close to residential properties in Brownsville. One resident suggested the district build a new library in the spot instead and abandon the idea of ball fields.
Folkman's surprise was evident.
"If the community doesn't want ball fields then you've just made my life a lot easier," he said with a laugh.
The subject occupied most of the 1.5 hour meeting and it became apparent the issue was at the heart of the residents' concerns.
As a compromise, they discussed two other options for the ball fields: making the temporary placement of the fields permanent, or moving the fields toward the northern end of the campus, away from the residential area.
Their main concern addressed, the crowd then touched upon the previous meetings, which Walker said inspired the community gathering.
"Those meetings had the entire board there… why weren't we notified?" said Louis Smith, a resident of the area and the founder of the Community Resource Center.
"We picked a microcosm" of the school's future attendees, said Councilman Brown. "The Board always intended to have a broader community meeting. There was always going to be another meeting."
The residents were not satisfied with his answers and the meeting temporarily lost order.
Mazyck pointed out his house on the map – directly across from the Elementary School 3 property – to illustrate the group's point.
"The immediate participants needed to be involved very early on. Those who live here have a concern about how this will interfere with our quality of life," he said.
The discussion of the property location also raised the question of naming the new school. Much to the dismay of the attendees, Folkman said the school board is already accepting suggestions and the final decision will be made at their second meeting in January.
A breakdown in communication became the topic of the remainder of the meeting. Most residents said they were being unfairly excluded from information, using the school naming as an example.
Folkman tried to help the group by explaining the information is public and discussed at all school board meetings, as well as posted on websites.
But the community cannot access those types of information distribution, Mazyck said.
"The traditional form of communication for this community is through churches," Mazyck explained.
Vice Chair Stoudenmire suggested the group have a representative attend board meetings and get into contact with the district's public information officer.
Not all were in agreement though. Resident Mat Profit said his neighbors aren't taking responsibility for their own problems.
"It's a hard fact, but it's true. You're asking for the information but no one takes the time to read it. Tell me and I will put you on my [information distribution] list. We want to be as organized and purposeful as possible," he said. "We've got to change our attitude."
Profit, who's a member of the district bond referendum oversight committee, mentioned reading The Journal Scene and attending school district board meetings as ways his neighbors can get information.
"You've got to be more involved with your community," he said.
With most of their concerns aired and a proposed way forward on the table, the meeting adjourned. As a next step, the residents resolved to form a committee to lead the initiative for more information and higher community involvement. Both the politicians and the public agreed to be more communicative moving forward.
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New York Food Dialogues
Contact: , 308-697-3486;
Have you checked out the videos from the USFRA Food Dialogues, New York?
The Beef Checkoff Program was established as part of the 1985 Farm Bill. The checkoff assesses $1 per head on the sale of live domestic and imported cattle, in addition to a comparable assessment on imported beef and beef products. States retain up to 50 cents on the dollar and forward the other 50 cents per head to the Cattlemen's Beef Promotion and Research Board, which administers the national checkoff program, subject to USDA approval.


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Welcome home Outlaws Nation! After a 2-0 road trip to Boston and Long Island, Invesco Field at Mile High welcomes back your Denver Outlaws tonight at 7pm.
Ready to match up against the defending MLL champions, Chesapeake Bayhawks, the Colorado evening sky will provide the perfect backdrop to welcome back midfielder
Max Seibald and the rest of your run-and-gun Outlaws.
Seibald missed the start of the 2011 MLL season due to a knee injury suffered during the indoor lacrosse season. Inside Lacrosse recently put Max through a mock NFL combine and found his numbers to be consistent with top-caliber NFL draft picks. Inside Lacrosse filmed the proceedings, which you can watch
The coaching and management staff announced the three captains for this 2011 season to the team during this morning's practice. Serving as captains this year will be attackman
Brendan Mundorf, goalie
Jesse Schwartzman and midfielder Max Seibald.
Jordan Hendry #37


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The former Orlando police chief and Democrat trying to unseat Rep. Dan Webster is the target of attacks.
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"An impressive, melodic and confident new work...The folk world is getting bolder!" ****—The Guardian
"Under One Sky could serve as a primer for anyone wanting to get an inkling as to what makes the contemporary folk scene as exciting as it is." —BBC Music
One of Scotland's most accomplished and versatile musicians of any genre, John McCusker is a multi-instrumentalist, producer and composer who has worked with artists as diverse as Mark Knopfler, Paul Weller and Patti Smith, Teenage Fanclub, Billy Connolly and Kate Rusby.
UNDER ONE SKY brings together an array of established and emerging talent from across the UK, including Blur co-founder Graham Coxon, Idlewild vocalist Roddy Woomble and acclaimed Gaelic songstress Julie Fowlis. Revered balladeer John Tams and rising star Jim Causley also feature among the singers. McCusker himself heads an all-star instrumental line-up of Andy Cutting (accordion), Ian Carr (guitar), Emma Reid (fiddle), Iain MacDonald (bagpipes/whistles/flute), Ewen Vernal (bass) and James Mackintosh (percussion). Within McCusker's compositional framework, each musician has plenty of room to showcase their individual voices as well as the power of their collective collaboration. McCusker explains, "Every musician strives to keep doing exciting things, musically, and to play with great people to keep them inspired. Getting to collaborate with these musicians has been the highlight of my musical career so far!"
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'Gorami' | Leather Mixed-Media Biker Jacket by BOSS
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Model is 6'2" with a 32" waist, 40" chest, and is wearing size 40R.
Model is 6'2" with a 32" waist, 40" chest, and is wearing size 40R.
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Welcome to our weekly edition of what's hot in social media news. To help you stay up to date with social media, here are some of the news items that caught our attention.
What's New This Week?
Facebook News Feed Update Delivers Higher-Quality Content: Facebook will "be doing a better job of distinguishing between a high-quality article on a website versus a meme photo hosted somewhere other than Facebook when people click on those stories on mobile. This means that high-quality articles you or others read may show up a bit more prominently in your news feed, and meme photos may show up a bit less prominently."


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SALEM - Aside from details, a big part of the 8th Annual Salem Super Cruise checklist met with approval during Wednesday's meeting while an additional event was proposed.
The Super Cruise will be held the weekend of June 20-23 and is in its fourth year under city management.
Fourteen people attended the meeting.
Dominic Righetti and his father, Mark, presented the idea for an autocross, a speed but mostly skill event in which drivers race against the clock on a short enclosed course.
It's a race around cones, Dominic Righetti said and Ken Kenst, the service safety director managing the Super Cruise, asked about a course size.
Righetti mentioned Walmart or the high school parking lot as far as that went, and Tom Hall, a co-coordinator of the Show 'n Shine, wondered about liability noting that it was an issue a couple of years ago when "kiddie rides" were proposed for the east side.
Mark Righetti said autocross "is a bunch of cornering ... and more about controlling your vehicle."
Judy Sicilia said, "I think it's a good idea ... it brings in a whole different type of people ..."
Dominic Righetti said it could work as long as "you keep track of the people" in response to a question about registration.
He thought an outside organization like the SCCA (Sports Car Club of America) could run it.
Mark Righetti said that Salem would give them the opportunity.
"Salem would just give them the space," he said.
Kenst said it wouldn't infringe on any activities and Super Cruise consultant Jim Bonfert wondered about an entrance fee and prizes.
Dominic Righetti said it would probably be better without an entrance fee and Kenst asked that Righetti check into it further.
Concessions, entertainment, advertising, sponsors, parking and
communications were all discussed. Kenst said the Salem Amateur Radio Association expressed an interest in helping out with communications "especially for the parking."
He also noted that Steve Rouse of Salem Area Websites offered to create a website for no charge for the 2013 Super Cruise. A graphic designer, Rouse will design a T-shirt for the cruise too.
Also, Kenst said Kyle Cranmer, co-owner of Salem Tire, the Goodyear tire retailer, was pursuing the Goodyear Blimp for the event.
"There are still some things we're working on," Kenst said, but the up front things "are really on the way."
Sam Sicilia said he had contacted Cody Roth of "Rat Fink" fame to attend this year but his schedule was too tight. Roth is the stepson of "Big Daddy" Roth, the creator of the icon hot rod character "Rat Fink" and others.
Hall said the Show 'n Shine is set for Sunday at the city lot across from Timberlanes from 11 a.m. until 3 p.m. He said sponsorship was still unresolved. Expert Tire has sponsored the event in the past.
Roe Haskin asked about approaching Summit Racing for overall event sponsorship and Kenst said that Bonfert "worked that real hard last year."
Bonfert said Summit still sponsors its NHRA event at Norwalk a couple of weeks later but has provided T-shirts and hats.
The next meeting will be held at 7 p.m. March 27.
Larry Shields can be reached at email@example.com


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Fun sized for your enjoyment!
With everything from the aft ski ring to the bow-mounted trolling motor, the Q4 SF is a fun-sized fiberglass ski-and-fish boat ready to please everyone.
On the water sports side, in-floor storage is perfect for stowing your gear, while the aft swim platform makes for the perfect staging spot. For the anglers, the bow fishing position provides a great casting spot and easy access to the trolling motor.
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Plush seating throughout, a built-in cooler and stereo system complete this fun-filled package.
Have a question about the 2013 Tahoe Ski & Fish Q4i SF?


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At a school the size of Heidelberg, there's a connection between the entire student body. So it shouldn't be a surprise if the disappointment over the HU football team falling in its playoff game had a carry-over effect on the men's basketball team that tipped off roughly an hour later across town.
Heidelberg coach Anthony Gholson said he felt that may have been the case, as his team fell behind Miami-Middletown 46-24 at halftime.
"I think really, ultimately, mentally they were a little bit down because of the football game," he said. "At this school, at this level, those guys all go to school with each other. They love each other, they're rooting for them the whole time. While we're getting prepared to play, they got they're ear listening to the football game."
In the second half though, these Student Princes made sure there was a positive ending to the school's day, rallying for a 73-71 win.
"We had a rough first half where we didn't play our best. We were lazy, came out slow. But we stayed locked in throughout the whole game, believed in ourself," Heidelberg's Jackson Blue said. "We played hard in the second half and came back and kept fighting back, kept chipping and executed in the second half and came out with the win.
"I think we picked up the intensity. We had more enthusiasm, played harder. In the first half we were real sluggish. Second half, we picked up the intensity and got after it."
While an emotional carry-over from the football game may have played a role in Heidelberg's slow start, other factors contributed.
Heidelberg shot 24 percent from the field, including 1-of-12 from behind the 3-point line, Nate Davis missed the majority of the first half in foul trouble, Miami-Middletown cleaned up on the boards and Heidelberg couldn't contain the Thunderhawks' Antonio Ferrell Jr., who scored 22 of his 32 points in the first half.
"That dude's a runaway freight-train," Gholson said of Ferrell. "Then he pulled out a 3; then he pulled out a left-handed shot. We didn't have any answer for him. He's just a physical presence. But Nate was able at the end of the game, defend him and get a rebound when it counted."
The Thunderhawks kept their advantage midway through the second half, before Heidelberg began to claw back in.
"I think what happened in the first half, we played what I call 'My turn to shoot,'" Gholson said. "Everybody was taking shots all over the place. Dudes were shooting 3's and they weren't going in. Then they weren't playing any defense. ... They turned it around simply because we started getting layups. We were taking tough shots in the first half; we got easy shots in the second half. Whether they were steals, or whatever they were, we got easy shots around the basket."
With just under eight minutes to play, Heidelberg began its furious charge. It started with a driving layup from Dane Givner that chipped the deficit down to 15. Next time down the floor, Ricky Slaughter completed an And-1 play, then on the other end of the floor, blocked a layup attempt by Farrell.
Slaughter got fed the ball going back down and hit a jumper to bring HU within 10 at 66-56.
Heidelberg also began to turn things around on the glass with Blue and Nate Davis dominating inside on both ends of the floor.
"First half we didn't really crash too hard," Blue said of the Thunderhawk's early rebounding advantage. "We just had our two big men. Second half we sent most people, had one person back. We got tips, got lose balls and just attacked as hard as we could.
"We just kept crashing the boards as hard as we could. They didn't really box out. They were just jumping. They didn't really get a body on people. So we just kept crashing the boards hard and got tip-ins."
A pair of layups by Blue and one by Davis off an offensive rebound trimmed the lead to one at 71-70 with 2:21 to play.
A steal by Slaughter got the ball back to Heidelberg and Blue drew a foul with 59.3 left. He sunk both foul shots to give the Student Princes their first lead since the game's opening minutes.
The Heidelberg defense made it hold up, forcing Miami-Middletown into an off-balanced 3-point attempt on its next possession to help seal the win.
Gholson credits his team's toughness in the second half as a big reason it rallied.
"Our guys just started being tougher, that's all it is," he said. "(First half, Miami-Middletown) won every 50-50 ball. Then in the second half I think we won most of the 50-50 balls."
Blue led Heidelberg (2-0) with 16 points and 11 rebounds, with Davis adding 15 points. Cody Blizzard and Ishaam Smith Jr. each added 10.


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BELLEVILLE - Coordinators of the Central Pennsylvania World Hunger Association are gearing up for their 39th annual meat canning project and asking area residents to help.
Each year, the association provides a canning venue for the Mennonite Central Committee mobile meat canner. The cannery travels more than 9,000 miles across the United States and Canada annually, preserving meat for use in humanitarian outreach all over the world, according to the committee website.
According to the site, more than 1 million pounds of turkey, beef, chicken and pork were produced overall during the 2011-2012 canning season.
Rick Esh, Central Pennsylvania World Hunger Association secretary, said the CPWHA hopes to can 30,000 pounds of turkey locally this February. The cost of reaching that goal is nearly $60,000, he said.
"We don't have enough money yet," Esh said. "(Canning is) expensive, but it's a good purpose."
After processing, the meat is incubated and held to confirm safety before being shipped around the world to those in need, the website states. But Esh said 10 percent of the meat produced locally stays in the tri-county area.
"It's not only worldwide. It's locally too," he explained.
The annual canning event is slated for Feb. 11 to 14 at East Derry Fire Company in Lewistown. Though physical labor will be appreciated closer to the event, financial support is needed now to be able to order the meat and begin the project. At a kickoff meeting held Oct. 25 at Maple Grove Mennonite Church, treasurer Brent King reported that the association has only $15,650 in its account so far this year.
Donations can be sent to the ministry at Central Pennsylvania World Hunger Association, P.O. Box 76, Belleville, PA 17004.
"There's always bills that need to be paid as far as cans, shipping," Esh said.
Therefore, donations are received all year long and will either contribute to the current year's mission or be saved for start-up costs for the next canning season, Esh said.


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South Carolina's unemployment rate dropped to 8.4 percent last month, down 0.2 percentage point from February, according to new figures released today.
The S.C. Department of Employment and Workforce reported that the number of those employed in the state last month was 1,992,113, and the unemployed totaled 182,978, the lowest level since October 2008.
The leisure and hospitality reported the biggest gain, with 9,800 more jobs, as the tourist season gears up. The largest part of the increase was from the accommodations and food service employers.
The Palmetto State's decreasing unemployment rate follows the nationwide trend.
The U.S. unemployment rate dropped to 7.6 percent last month, 0.1 percent lower than February.
South Carolina's March jobless rate was 0.9 percentage point lower than the same month in 2012.
The Charleston region's jobless number dropped to 6.4 percent last month from 6.8 in February.
Check postandcourier.com later for more updates.


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Top Definition
A member of the American white supremacist organization the Ku Klux Klan (KKK).
A person who hates gays, jews, catholics, blacks, latinas and anyone else non-American, white, and Protestant.
A person who hates gays, jews, catholics, blacks, latinas and anyone else non-American, white, and Protestant.
The kluckers have been laying low since they blew-up that gay bar.
ayon kay Blowfish ika-27 ng Agosto, 2005
Trending Now
Can you define these popular missing words?
n. (Klux + -er): 1. A member of the Ku Klux Klan. 2. Used pejoratively, a white American who is perceived to be bigoted, particularly in matters of black / white racial integration.
Look at that old klucker up on the courthouse steps, bawling his head off about "them nigras."
ayon kay Carl Willis ika-13 ng Mayo, 2005
A Klucker is a person whos mum and dad are usually from the same family or brother and sister. They hate blacks,gays, Jews, Catholics, Indians, Hispanics and well basicly anyone who is none white and non American. They don't seem to realise that most whites hate them.
"Hey who is that person over there wearing his bed sheets?" "Oh thats an inbred Klucker"
ayon kay Merleen ika-01 ng Oktubre, 2006
A stupid clueless mother fucker
Man that guy is a Klucker.
ayon kay Toler ika-29 ng Hulyo, 2005
A Clueless Fucker.
Man that guy was such a klucker.
ayon kay christopher cook ika-23 ng Hunyo, 2005
A crack head. Ice Cube used the word clucker back in his NWA days
. .. but in called a klucker
ayon kay SoClean ika-28 ng Nobyembre, 2005


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This item is delivered by our In-Home Delivery Service. With In-Home delivery, the item is brought into your home, unpacked, and assembled (except for some headboards and Style-It Desk components, which are not unpacked or assembled. Our service also does not mount hutches and shelves to customer's walls.) Delivery is by appointment. Weekdays in all areas; Saturday delivery in some areas. Our delivery service will contact you to arrange a day. This service is available in the contiguous 48 states only. Please allow approximately 2-3 weeks for delivery.
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Wednesday, March 20, 2013
Well, I got called out over the weekend for mentioning the dreaded mole in my last article, and I did not go into the details on how to control them in the article. For the long version, go to MoultrieNews.com and look under the columnists, or go by your local Possum's Landscape & Pest Control Supply near you for a handout we have for mole management.
The quick and dirty method involves three steps. Be sure to do these steps in order.
1. Kill the mole. Traps, proven baits (Mole Patrol, Talpirid, etc), smoke bombs.
2. Manage the food source. Sevin or Aloft granular are very effective for managing the food source of the mole. Many products do not kill sub surface insects, so be sure to use an insecticide that does.
3. Repel new moles from your yard. Holy Moley (granular) or one of the liquid mole repellent products will help deter new moles from entering your yard and occupying the old tunnels.
If you have liriope, holly fern, cast iron plant, pampas grass or other ornamental grasses, this is the time to cut them back.
A sharp pair of hedge shears will do a nice job on the larger stuff, and a lawn mower with a sharp blade will take care of the liriope. Mexican heather and other burnt back perennials could also be sheared at this time.
Using Neem Oil now will help kill over-wintering insects as well as adults. This product also controls certain diseases. Insects and disease love the new foliage that your plants are getting ready to put out, so kill them before they munch on or damage your new foliage. This product is organic and very safe for the environment.
Your trees and shrubs are going to do most of the growing for the season during the next month. Put out fertilizer so they will have plenty of food to put out new foliage and grow. 17-00-09 a 100 percent slow release fertilizer, or many of the organic products in combination with SeaHume will be a sure way to get your plants off to a good start in 2013.
If you have any perennial insect problem plants (white flies-gardenias, scale-magnolias, scale-camellias, scale-hollies, lace bugs-lantana, aphids-crepe myrtles…), try Dominion Tree and Shrub. This product is a drench that lasts a long time in the plant, so you don't have to worry about spraying weekly.
If you have not put out your preemergent product for your turf and beds, consider one that contains Dimension for its long reach back potential. Be sure to you use the proper amount of Dimension for this area.
There is some low active ingredient Dimension in the area (ai amount 0.1 percent, 0.13 percent, or 0.15 percent) which is fine if you spread the proper amount of product; however, not everyone realizes this (ex. If a 50 pound bag of a 0.20 percent Dimension covers 10,000 square feet, then a 50 pound bag of a 0.10 percent Dimension only covers 5,000 square feet). Do not be fooled by the low bag price.
Always read, understand and follow product label. The product label is a federal law.
Bill Lamson-Scribner can be reached during the week at Possum's Landscape and Pest Control Supply. Possum's has three locations including one at 481 Long Point Rd. in Mount Pleasant (971-9601). Bring your questions to a Possum's location, or visit us at http://www.possumsupply.com. Call in your questions to "The Garden Clinic," Saturdays from noon to 1 p.m. on 1250 WTMA.
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Of the acres reported upon, 99% were planted to Roundup Ready® sugarbeet varieties. Total beet acreage treated with herbicides in 2013 (taking into account multiple applicatons) was 232%. While that level was slightly higher than 2012's 208%, it was lower than most of the past several years. In 2007, for instance, the last year prior to the introduction of commercial Roundup Ready beets in the region, herbicide treatments stood at 383%.
Read this entire issue and back issues. Click here.


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Parole Board News
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Ohio Revised Code (ORC) section 5149.10 created the Parole Board as a section within the Adult Parole Authority consisting of up to twelve (12) members, including the Chair. The members are appointed by the Director of the DRC, and must be qualified by education or experience in correctional work, including law enforcement, prosecution of offenses, advocating for the rights of victims of crime, probation or parole, in law, in social work, or in a combination of the three categories. Members, except the Chair and the Victim Representative, appointed after September 30, 2011, will be subject to term limits of two (2) six (6) year terms. The Director, in consultation with the Governor, must appoint one individual to the Board who is a victim of crime, a member of a victim's family, or who represents an organization that advocates for the rights of victims of crime. The Parole Board currently consists of twelve members whose primary statutory duties include conducting release consideration hearings on all parole eligible inmates and providing clemency recommendations to the Governor.
ORC section 5149.10 also provides for "any other personnel that are necessary for the orderly performance of the duties of the board." Additional Parole Board personnel include a staff of 14 Hearing Officers, including three supervisory Chief Hearing Officers. The primary statutory duties of the Hearing Officers are to assess all inmates sentenced after July 1, 1996, and determine whether or not Post Release Control will be required after release, and to conduct field violation hearings to determine if violations of the conditions of supervision have occurred and recommend an official response to the violations.
There are also 22 Parole Officers assigned to the Parole Board. These officers assist in preparing hearing materials, submit Transitional Control recommendations and conduct clemency investigations. They are headquartered at various correctional institutions throughout the state, and are supervised by four Quality Assurance analysts.
Administrative staff of the Parole Board includes an Executive Assistant, three Criminal Justice Planning Specialists, and two support staff. These staff are integral in ensuring the orderly processing and administration of the Parole Board's duties and functions.
To submit an email concerning an Offender's Parole Board Hearing, please fill out and submit the Parole Board Email form.


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Top Definition
What your insurance company sees when you've got a ticket that causes your rates to go up.
If you get a reckless speeding ticket, when you get in front of the judge, request that judification be withheld so that your insurance rates don't go up!
автор: mwelc004 13 мая 2007
Trending Now
Can you define these popular missing words?


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Heads Up for Low-Flying Planes
A park is carved out amid aircraft in Santa Monica,
By Morris Newman
Like a plant sprouting through a crack in the pavement, the
Santa Monica Airport Park appears to have broken through the asphalt and
concrete of this industrial site in the West Los Angeles area. This is how a
park might look if parks had wills of their own and were able to assert their
greenness into a largely plant-free environment of old stucco buildings,
hangars, and small aircraft tie-downs.
While a park tucked inside a general aviation airport might
seem incongruous to some, none of the two dozen people present on a July
afternoon seemed to notice. A succession of parents retrieved their
six-year-olds from summer camp. Couples walked up and down sloping pathways on
either side of this long and narrow park. Two large dogs, one yellow and the
other black, lolled in the soft decomposed granite in the off-leash area,
ignoring repeated calls of "come 'ere, boy." Only the soccer fields were empty,
although they get plenty of use during evenings and weekends.
The popularity of the park is easy to understand: Open space
is scarce in this dense residential area, where the small, oceanfront city of
Santa Monica meets the larger city of Los Angeles. Although Santa Monica
generally gets good marks for open space, this part of town is park starved,
and the airport facility is the first new park in this rapidly growing city in
24 years. The full-to-overflowing program of dog park, tot lot, picnic tables,
active green space, sports fields, plus a concrete platform for large-scale
public art installations, testifies to the pent-up demand for active open space
in a largely single-family neighborhood. (During opening day festivities last
year, a group of Los Angeles residents picketed the park, protesting the ban on
Los Angeles dogs in the Santa Monica park. Santa Monica, a socially conscious
city, later opened the dog park to all, controlling crowds with a licensing
Santa Monica Airport Park is a long-held, hard-won goal of
the city. Prior to the design of the park, the city hired Ah'bé Landscape
Architects to create a master plan of open spaces throughout the 227-acre
airport. The airport park, located just off a major boulevard, is the first
open space in the master plan to be realized.
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Outdoor Interlaken inaugurates a fixed rope park in the Wagern Gorge on the Rugen. Nine Parcours of different lengths, difficulty and heights are planned in a beautiful forest with granite blocks dating from the last Ice Age, 18,000 years ago. This is an adventure for the entire family against the backdrop of the Eiger, Mönch and Jungfrau.
The fixed rope park is a 15-minute hike away from the train station Interlaken West. Parking is available.


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WATCH: Bonnie McKee defeat zombies in 'Sleepwalker' music video
Posted October 18th, 2013 @ 1:49pm by Samantha Martin | Popdust
Listen to Bonnie McKee on iHeartRadio
When "American Girl" singer Bonnie McKee isn't writing hit songs—she's got eight No. 1′s (!)—or dreaming about Eminem, she's fighting zombies. Or at least that's what she's up to in the music video for her uber-catchy new song "Sleepwalker." Watch the vid, and beware of "soul-sucking viruses."


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on February 14, 2013 - 10:00 PM
, updated February 15, 2013 at 4:33 PM
The planned merger of American Airlines and US Airways would create the world's biggest airline and bring together the third- and sixth-busiest carriers at Buffalo Niagara International Airport.
The two carriers that are now combined offer 22 percent of all outbound flights, and their union raises questions about the impact on service and fares.
There is little overlap among their routes out of Buffalo, with American providing service to Chicago, and US Airways flying to Boston, Philadelphia and other major East Coast airports. This bodes well for local travelers, but the deal's full effect won't be known for some time.
"I think it is too early to actually speculate as to how a merger would affect our airport," said Niagara Frontier Transportation Authority spokesman C. Douglas Hartmayer. US Airways is the third-busiest local carrier, and American the sixth.
The American-US Airways marriage is the latest in a series of airline combinations in the last five years, following the mergers of Delta with Northwest, United with Continental and Southwest Airlines with AirTran Airways.
The boards of American and US Airways approved the $11 billion merger Wednesday, and the companies announced the deal Thursday.
American's parent company, AMR Corp., still is under federal bankruptcy protection and will need the court to approve the deal. US Airways shareholders also must vote for a merger, and the transaction is subject to approval by federal regulators.
The merger would leave the country with four major airlines: the new American, United, Delta and Southwest.
American would have 900 planes, 3,200 daily flights and about 95,000 employees, not counting regional affiliates.
"The combined airline will have the scale, breadth and capabilities to compete more effectively and profitably in the global marketplace," US Airways CEO Doug Parker said in a statement. "Our combined network will provide a significantly more attractive offering to customers, ensuring that we are always able to take them where they want to go."
The airlines said they expect $1 billion in combined benefits from the merger. The companies could save money by combining their reservation systems, for example, or by using their joint buying power to negotiate better prices on fuel or spare parts, said Harold Star, a visiting assistant professor at the University at Buffalo School of Management who studies business strategies.
"The real question is: How sure are you in your analysis of the expected efficiencies?" said Star, who pointed out that the final amount saved on training or maintenance costs hinges on whether the airlines fly the same planes.
As recently as 2004, US Airways was the No. 1 carrier at the Buffalo airport, with 27 percent of flights and 22 percent of passengers.
But Southwest and JetBlue now control 54 percent of passengers and 39 percent of flights going out of Buffalo, according to the NFTA. "US Air was dominant for years, until JetBlue and Southwest came," Hartmayer said.
American, which flies out of Buffalo under its American Eagle name, offers only outbound service to O'Hare Airport in Chicago, while US Airways flies to Boston; Charlotte, N.C.; Philadelphia; and Reagan National in Washington.
Kenmore travel agent Steven J. Elliott said the airline's service through Chicago is convenient for people heading to the West Coast and the southwestern United States.
However, he said, US Airways has several early morning flights, allowing vacationers to fly out of Buffalo by 5:30 a.m., connect through Philadelphia and arrive in Cancun, Mexico, before 11 a.m. "They really have some of the best schedules," Elliott said.
US Airways uses five gates at the airport, while American Eagle has one gate, out of the 24 total gates, including four that are currently open, Hartmayer said. US Airways has six ticket stations inside the airport terminal, while American Eagle has three.
Sen. Charles E. Schumer, D-N.Y., raised concerns about such a merger in May, citing its possible effect on service to upstate New York airports. "I will be watching like a hawk to make sure that the thousands of jobs and service to 13 New York cities is maintained as part of this merger," he said in a statement.
Further consolidation could raise airfares, as the price of a domestic round-trip flight has climbed by more than 11 percent since 2009, according to the Bureau of Transportation Statistics.
UB's Star, however, said competitive pressure has kept fares in check in recent years, with airlines charging increased fees for bags and prime seats to find new ways to raise revenue.
"No reason to see [fares] go up," Star said, "because there's still too many actors on the market."
The Associated Press contributed to this report. email: email@example.com


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The complete pictures of KC Concepcion @ Rogue Magazine
KC in Rogue Magazine bakat na Nipples at ang alaga niyang ahas na si Coco!
KC in Rogue Magazine
Beautiful KC in Rogue Magazine
KC in Rogue Magazine
Sexy KC in Rogue Magazine
KC in Rogue Magazine
KC in Rogue Magazine Cover
KC in Rogue Magazine so sexy~!
Go buy your copies now. My friend will be buying two copies! Ha ha ha! I want a copy too~!
KC CONCEPCION'S COMPLETE ROGUE MAGAZINE PHOTOS source: Spanky Enriquez thank you my dearest~!
Other articles about KC Concepcion:
KC and Piolo Rogue
Sexy KC Concepcion's X-factor and Pet Snake
Sexier Photo of KC Concepcion for Rogue Magazine
Daring KC Concepcion in Rogue Magazine
KC Concepcion Rogue Magazine Cover Trended on Twitter
KC Bikini Cover Shoot for Cosmopolitan Magazine
KC Concepcion dons two-piece Bikini on Cosmopolitan Magazine
ABS-CBN PR heads vs. KC Concepcion
Mark Bautista tagged as third party in the Piolo Pascual and KC Concepcion break-up?
Piolo and KC's break-up
Sharon Cuneta - KC's new suitor is real man
KC Concepcion 2013 Tanduay Cover Girl


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Source: Reuters
quote: I don't get why people have this issue. I don't have this problem in my Win7 64-bit. I have 120GB SSD on my laptop, and a 256GB SSD for my desktop (where it's partition in 2, 50GB for Win7, and the rest on the other partition (data, programs, games, etc.)


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on January 8, 2013 - 12:19 AM
Longtime former Boston Red Sox reliever Bob Stanley was named pitching coach of the Buffalo Bisons on Monday as the parent Toronto Blue Jays completed manager Marty Brown's staff.
The Bisons' hitting coach will be former big-league outfielder Jon Nunnally, who was the hitting coach for the Cleveland Indians in 2010-11 and worked with Buffalo Baseball Hall of Famer Torey Lovullo at Triple-A Columbus in 2009.
Stanley, 58, worked with Brown last year in Las Vegas and the 51s had a 4.59 ERA for the season, the sixth-best in the 16-team Pacific Coast League. This will be Stanley's 14th season as a minor-league pitching coach. He had previous stints in the Mets and Giants organizations, mostly in the Double-A Eastern League.
Stanley pitched all 13 years of his career in Boston and was the franchise save leader with 132 until Jonathan Papelbon passed him in 2009. But he's best known, of course, for one that got away in Game Six of the 1986 World Series against the New York Mets.
It was Stanley who threw the wild pitch past Rich Gedman that allowed Kevin Mitchell to score the tying run with two outs in the bottom of the 10th inning. Mookie Wilson's roller then went through the legs of Bill Buckner to plate the winning run.
The Blue Jays have also announced Voon Chong will be the Bisons' trainer. Armando Gutierrez will be strength and conditioning coach.
The Bisons open their season April 4 against Rochester in Coca-Cola Field.


text:
Published November 18, 2013
UB student Phillip Tucciarone, a senior chemical and biological engineering major, is a finalist for the prestigious Marshall Scholarship.
A recipient of the 2013 Barry M. Goldwater Scholarship, Tucciarone is UB's first finalist for the Marshall Scholarship since 2008.
Each year, the award finances graduate study for 40 American scholars at a university in the United Kingdom in any field of study. If selected, Tucciarone would use the scholarship to obtain his doctorate in materials science at either the University of Oxford or Imperial College of London.
Tucciarone interviewed with the scholarship committee in New York on Nov. 16; he will hear final results this week.
If selected to receive a Marshall Scholarship, he would join the transcending research currently underway on graphene, one of the crystalline forms of carbon. Fueled by his desire to become a professor of materials science, Tucciarone has devoted much of his undergraduate research to nanomaterials and the development of methods of nontoxic bio-imaging, which play a role in cancer treatment.
Tucciarone's studies have earned several awards, including the UB School of Engineering and Applied Sciences' Undergraduate Research and Scholarship Award of Distinction. He also has co-authored and published two papers on his studies in ACS Nano and Nano Letters, both monthly, peer-reviewed, scientific journals published by the American Chemical Society.
"I see education as the strongest mechanism for change in the world," says Tucciarone. "I want to bridge the gap between the United States and UK as a diplomat, gain experience and work as a bridge for bilateral research and higher education."
Tucciarone's passion for education drives him both in and outside the classroom. An Honors College scholar, he maintains a nearly flawless grade-point average while playing as the starting wing for UB's club rugby team.
He is also president of the Honors Student Council and works with inner city public schools through the Interdisciplinary Science and Engineering Partnership, a program that seeks to improve science education in the Buffalo Public Schools.
During a community service program in the Dominican Republic, Tucciarone volunteered to help teach English to the local youth. The experience opened his eyes to the inequalities in education and inspired him to organize an annual volunteer service trip to the country through the Honors Student Council.
"In my 20-plus years teaching at UB, I've never seen such a display of leadership in one of my students," says David Kofke, SUNY Distinguished Professor in the Department of Chemical and Biological Engineering. "It is heartening to see this in an engineering student, where the workload promotes immersion in coursework without allowing time to take in the larger picture in life, let alone participate in it."
Founded in 1953 in honor of U.S. Secretary of State George C. Marshall, the Marshall Scholarship works to strengthen the relationship between the British and American citizens, and their governments and institutions.


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Top Definition
The projects on the oposite side I-10 from the Superdome. Notoriously rough and at odds with other New Orleans projects like the Melpe, St. Thomas (gone), Iberville, Lafite, and the Fisher. Numerous rappers, athletes, and Angola inmates got there start here.
Let's see L.L. walk through the Calio (Gregor D. lyrics).
door Chris " bitch booty licken" Parker 3 april 2006
Trending Now
Can you define these popular missing words?
B.W. Cooper housing developments (projects) formally and presently known as the Calliope (Calio). Home and roaming grounds to local rappers including but not limited to UNLV, BG, Juvenile, Lil Wayne, Soulja Slim (Magnolia Slim), and Baby.
"From the Mac to the Melph to the Calio"-UNLV
door UptownSoulja 5 februari 2005
Marijuana born and raised in the state of California. The best dank you can get your hands on.
Tourist: Yo look at this!! I just got some BC and Amsterdam bud!!
California Local: Haha good one. Sorry bro but I have a date with some cali-o tonight.
California Local: Haha good one. Sorry bro but I have a date with some cali-o tonight.
door fertileturtle 5 augustus 2009
When you stick a girl's hand up your asshole and flex so hard that her fingernails crack.
I Calios'd that bitch. What a cunt.
door titballzlulz 8 februari 2008


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Actually when you look at the +GOE scores, they did OK. They got mostly +1 with a dozen or so +2 sprinkled in, especially in the step sequence, which I like a lot. So the judges are saying as far as execution they were solid (though they can easily score more +GOE; they can get +3 on the twizzles)
ETA: Missysays I think summed it up well earlier RE: technical ability
The Shibs have not dropped technically, but just doing something "different" does not automatically make it good. Doing a "polka" to this music is really ridiculous. Can't image what Marina was thinking.
Seriously though, I'm a bit torn. My first inclination is also to trash it and start with something new; so if they end up doing that I won't be terribly disappointed about it. But after hearing Imaginary Pogue's comments, watching it several times (to see what IP was talking about) and watching it back to back with the Duchesnay program, I don't think it's a complete loss either. They have a beautiful opening step sequence that was well timed to the music.
YMMY (clearly, as we've seen in this discussion) -- but I can go either way as far as this SD. But the thing we learn with the Shibs is they work quite hard and are great about refining programs, even in a short time. (See last year's SD when they did two GP events back to back). So perhaps that is a case that they can do a new SD as well and quickly.
The worst issue for the Shibs is not the fact the Duchesnays skated to Dolencias & Sikuriade first, it is that I&K skated to this music as a folk dance OD when they won Jr. Worlds in 2010
The sound on the above vid is dreadful. A better version is their JGPF version
A disastrous competition for the Shibs, who finished 4th overall and fourth in the OD.
BTW, the Duchesnay's used the version by Inti-Illimani, not Incantations
(and I Like the Inti Illimani versions better)
Not to mention that there are lots of other songs by these groups, if you want to dance to Andean music You don't have to use the same 2 songs.
The Duchesnays also used Cachapaya, is by Incantations is this version
Last edited by dorispulaski; 11-10-2012 at 04:57 PM.
The trouble I have with the Shibs program is that they aren't connecting with the music at all. They have some interesting movements, but it's like they're doing the movements to the music, rather than dancing with the music. They aren't capturing the spirit of the pieces. Maybe because they started this program so late?
I saw the Shibs live at 2010 US Nationals. Absolutely, they connect to the music. They have an absolutely superior sense of timing when they are completely comfortable with their programs-not surprising as they are the children of musicians. (Mom is a concert pianist, dad plays the flute)


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|Food & Cooking
Closed Captioned
Explore healthy Mediterranean cooking techniques with renowned cookbook author and chef Diane Kochilas. Learn how to build a Mediterranean flavor palate for marinades, pastes and dressings with basic ingredients such as olive oil, citrus and herbs. Find out how to cook greens you'll crave in dishes such as tomato-braised sweet greens wrapped in flaky phyllo. Then, discover techniques for transforming vegetables like eggplant into rich spreads, dips and sauces. Next, kiss bland beans goodbye as you make a versatile flavor base packed with juicy plum tomatoes, sweet red onion and, of course, garlic! Finally, learn how to prepare, grill and roast lean meat and seafood for healthy and mouthwatering main course options that will have your family clamoring for more!
Meet your instructor, chef and cookbook author Diane Kochilas, and learn more about the techniques and dishes covered in your class. You'll enjoy watching all the way through or dipping into individual lessons to review a particular technique or to cook a dish along with Diane. In this first lesson, you'll begin by building Mediterranean flavors with three foundations for a variety of dishes: a savory herb paste, classic yogurt marinade and an olive oil and lemon dressing that doubles as a marinade.
Make greens a favorite part of any meal with Diane's guidance for blanching and braising. Try sweet greens such as spinach, chard and bok choy or explore the possibilities of bitter greens such as mustard greens and dandelions.
Throughout the Mediterranean, paper-thin phyllo dough is used to wrap both savory and sweet fillings. Learn how to handle your dough to keep it from drying out and follow along with Diane as you roll up triangles, cylinders and spirals that are stuffed with braised sweet greens.
Baked or roasted eggplant is the perfect base for salads, dips and spreads. Achieve an intriguing smoky flavor by roasting eggplant over an open flame, then combine it with capers and feta cheese, walnuts and garlic or tahini and yogurt. This treat is perfect for a party, a snack or as a sandwich spread.
Create the classic flavor base for two casseroles featuring chickpeas or cannellini beans. You'll be delighted with how easy and economical these dishes are to prepare, and how tasty they are!
Learn the secrets to making delicious one-pot vegetable stews, called "ladera" in Greece. Add chicken marinated in olive oil and lemon juice, or garnish your plate with a skewer of yogurt-marinated chicken. You'll find satisfaction in the smaller portions of meat without sacrificing flavor.
Bring the Mediterranean Sea to your table with a marinated fish fillet on a bed of roasted vegetables, or try some seared shrimp mixed with tomatoes, onions, feta cheese and olive oil. Add a slice of good bread to soak up the juices of a delicious, healthy meal!
"This class is a great introduction to Mediterranean cooking, with each lesson building from the previous one. Diane is a terrific instructor and I've loved this class."
- Anniei01
Omaha, Nebraska


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NuGet: Add Reference, Awesome
- Day 1
- Speakers: Matthew Osborn
Right click "Save as…"
There's an Open Source package manager for .NET available now called NuGet. It's supported and shipping with ASP.NET MVC 3, but it's not just for ASP.NET. In fact, it's not just for open source. Join Matthew as we learn all about NuGet, from the basics of consuming packages, to creating and distributing your own packages both internally on your own server and externally on NuGet.org. Then we'll learn some advanced techniques like preinstalling NuGet packages into your own project templates and how NuGet can be extended and enhanced to write your code for you. We'll see how using NuGet with your project makes development fun again!
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College Football's Biggest Celebrity Fans ft. Will Ferrell, Matthew McConaughey
July 28th, 2014| by Lost Lettermen
Kate Upton (Michigan)
When they're not busy making movies, writing songs and appearing in photo shoots, these A-listers (and perhaps a few B- and C-Listers) can usually be spotted on college football sidelines. Here's a look at college football's biggest celebrity fans.
Sports Illustrated swimsuit model Upton is a Michigan fan through and through, returning for an annual family reunion for the Ohio State game. Her state allegiance doesn't stop at football either as her relationship with Detroit Tigers pitcher Justin Verlander is well noted.
Matthew McConaughey (Texas)
The UT alum has long been noted as a Longhorns devotee, and the school certainly paid back in kind when McConaughey won his first Oscar back in March. Former coach Mack Brown, current coach Charlie Strong and the University of Texas itself all tweeted their congratulations as McConaughey took home his statue.
Will Ferrell (USC)
Hollywood funnyman Ferrell is a vehement supporter of his former college stomping grounds (where he actually received a degree in sports information). A regular presence on the sidelines at football games and practices, Ferrell has even dressed up as Tommy Trojan.
Snoop Dogg (USC)
Thanks to its Hollywood-adjacent locale, USC doesn't lack for celebrity fans. Snoop Dogg has long been an avid Trojans fan and might get even more reason to show off his USC pride. His son, Cordell Broadus, is a 4-star wide receiver recruit in the class of 2015 who says USC is one of his top-five prospective schools. This could soon be a family affair.
Courteney Cox (Alabama)
Born in Birmingham and raised in Mountain Brook, Cox has Crimson Tide in her blood. The "Friends" and "Cougar Town" star once appeared in a promo video before the 2010 BCS National Championship Game, sending her Tide good vibes before they defeated Texas at the Rose Bowl.
Eric Stonestreet (Kansas State)
Emmy Award-winning actor Stonestreet is a Kansas State alum, making the rooting choice easy for the Kansas City, KS native. Among his involvements with the program, the "Modern Family" actor once appeared on "College GameDay" in 2011 in a full K-State jumpsuit.
Burt Reynolds, Florida State
It's easy for Reynolds to declare his fandom for Florida State, as he played halfback for the Seminoles in the '50s. Reynolds didn't forget his football roots when he became an actor, starring as Paul Crewe in The Longest Yard and appearing as Nate Scarborough in the revival.
John Legend (Ohio State)
While "All of Me" was written for Legend's supermodel wife Chrissy Teigen, it could double as his love letter to Ohio State. The UPenn grad is a Springfield, OH, native who proudly and openly roots for the Buckeyes. Plus, is there a cooler piano than the one Legend has plastered in buckeye and Ohio State stickers?
Ashton Kutcher (Iowa)
The Cedar Rapids native and University of Iowa alum has sometimes been too big a Hawkeyes fan for his own good. In 2010, Kutcher and then-wife Demi Moore were tied to NCAA recruiting violations when Iowa allowed basketball recruits to meet the couple at a football game.
Kenny Chesney (Tennessee)
One of country music's biggest stars, Chesney is a native Tennessean who's been a devout Rocky Top supporter since childhood. Chesney shows more than spirit, too. His philanthropy efforts include releasing the limited-edition single "Touchdown Tennessee" as a tribute to Vols football broadcaster John Ward.
James Carville (LSU)
Carville is an accomplished political strategist and commentator, a professor, an author and an ex-Marine, but the Rajin' Cajun's priorities arguably lie first and foremost with Tiger football. A native and lifelong Louisianan, Carville graduated from LSU in the '70s and has been a die-hard LSU football fan ever since.
Regis Philbin (Notre Dame)
Entertainment industry legend Philbin is known just as much for his talk-show resume as he is for his Irish fandom. The Notre Dame alum is such a diehard that he recorded the audiobook for Echoes of Notre Dame Football: Great and Memorable Moments of the Fighting Irish. Reeg also welcomed several Fighting Irish coaches as guests on his show, such as Lou Holtz, Tyrone Willingham and Charlie Weis.
Adam Duritz (California)
It's hard to call the Counting Crows frontman a Cal fan as much as he is a musician who moonlights as a college football insider. Duritz's loyalties to the program lie so deep and strong that he is an active reader and poster on recruiting sites and sometimes guests as a pregame and halftime analyst for Golden Bears broadcasts.
Larry the Cable Guy (Nebraska)
When Larry the Cable Guy isn't gittin-r-done as a comedian, he's paying close attention to Big Red football. The Nebraska native is a regular presence at Huskers games and practices, even being allowed to guest-coach a time or two. Larry takes Nebraska football with him wherever he goes — "Huskers" is written across his signature camo hat and he often sports an "N" chain necklace.
Joe Scarborough (Alabama)
Scarborough is a Georgia native and was a Florida congressman, but sometimes nothing can get in the way of undergrad allegiance. The "Morning Joe" host spent his college years in Tuscaloosa, where he developed an unbreakable bond to the Crimson Tide. He often gives shout-outs to the program on his show and has hosted the program from the University of Alabama several times.
David Letterman (Ball State)
Letterman will retire from his late-night post next year, but surely his Ball State fandom will never die. A noted benefactor to his alma mater's telecommunications department, Letterman even has a building named after him on campus. Sure, his program isn't as high-profile as him, but he remains an avid fan.
Luther Campbell (Miami)
The music and entertainment industry vet of "2 Live Crew" fame has had a dicey history with the U, allegedly operating the "pay-for-play" system that rewarded players for big plays. He also threatened to come clean about violations if the school did not start Ryan Collins at quarterback in 1993. It's been a morally ambiguous fandom, but an intense one nonetheless.
Ric Flair (South Carolina)
Close friends with Steve Spurrier, "Nature Boy" has moved his allegiance from the Florida Gators to the South Carolina Gamecocks. Of course these two are friends…
Channing Tatum (Alabama)
Alabama native Tatum made it known in a recent interview that when it comes to the Iron Bowl rivalry, his foot is staunchly in the Crimson Tide's camp. Of course, one needn't look any further than the average paparazzi photo of the 22 Jump Street star to know where his loyalties lie: firmly in Tuscaloosa.
Dwayne Johnson (Miami)
It's common knowledge now that "The Rock" was a highly recruited defensive tackle who helped lead the Hurricanes to their 1991 national title. Throughout his wrestling career and into his acting career, Johnson has remained a steadfast supporter of "The U" and his hometown Miami.
Bill Cosby (Temple)
Long before becoming one of the most revered comedians ever, Cosby had humble beginnings as a football and track athlete at Temple. Cosby played fullback with the Owls in the early 1960s. He dropped out before earning his degree, but the school eventually gave him a Bachelor's on the basis of "life experience" and he has repaid them with intense fandom of all things Temple.
John Mellencamp (Indiana)
How intense is Mellencamp's fandom for Indiana football? Just enough for him to be the lead donor for the $6 million Hoosiers' indoor training facility, dedicated as the "John Mellencamp Pavilion" in 1996. The singer-songwriter doesn't have to travel far to visit his creation, as he resides just outside of Bloomington.
Tom Arnold (Iowa)
Arnold has tried long and hard to be known as more than a marriage-to-Roseanne-Barr punchline, and one way has been branding himself as the foremost Iowa Hawkeyes fan. After attending the school in the early 1980s, Arnold has been an ardent fan, often promoting the Hawkeyes as the former host of the former "The Best Damn Sports Show Period."
Toby Keith (Oklahoma)
Yes, Keith was made in America. But more specifically, he was made in Oklahoma and is often seen showing his allegiance to the Sooners. Besides being a regular presence at football games, Keith released "Cryin' for Me (Wayman's Song)" as a tribute to his friend and Sooners basketball legend Wayman Tisdale.
Rush Limbaugh (Nebraska)
Whether or not fans want to associate with him, the fact remains Limbaugh is a steadfast supporter of the Big Red. His forays into football haven't always been successful (see: his stint on "Sunday NFL Countdown") but his support and fandom are unquestioned.
Rich Homie Quan (Michigan State)
Rich Homie Quan became a Spartan fan out of mid-air, but he appears here to stay. His song "Some Type of Way" became MSU's team anthem during the 2013 season. Dantonio then gave a shout out to the rapper after winning the Big Ten championship. Before long he was on the sidelines and in the locker room with the Spartans, celebrating their Rose Bowl victory.


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Magistrate Ben Shepler denied a request to modify bond for an Elkins man facing 36 felony charges - including incest and sexual assault - Friday in Randolph County Magistrate Court.
Derek Jason Shifflett, 30, is charged with 12 felony counts of incest; 12 felony counts of first-degree sexual assault; and 12 felony counts of sexual abuse by a parent, guardian, custodian or person in a position of trust to a child.
Shifflett's bond is set at $360,000 cash only and will remain so until Shepler has determined whether or not there is probable cause to bind the case over to a grand jury in Randolph County Circuit Court, the magistrate said.
Shifflett's preliminary hearing had been slated for Friday morning; however, his attorney, James Hawkins, requested a continuance in the case, arguing that he needed more time to prepare for the hearing and consult with Shifflett, who has been lodged in the Tygart Valley Regional Jail since early October. He remained there as of presstime Friday.
Shepler granted the continuance, but informed Hawkins that he would not modify bond until he had an opportunity to consider arguments made in the preliminary hearing.
"I will grant a continuance, but it's my policy that I will not modify bond before I hear the testimony in the case," Shepler said.
Shifflett was arrested Oct. 2 for allegedly sexually abusing a minor on multiple occasions from Sept. 27, 2011, through Sept. 27, 2012.
Although Hawkins conceded the charges lodged against Shifflett were "repugnant," he called the $360,000 bail excessive.
"When I was looking at the bail, I actually thought it was a mistake," Hawkins said. "$360,000 cash? If that's not a denial of bail, nothing is. We might as well make it $100 billion. How is $360,000 not excessive?" Hawkins argued there was no existing evidence to suggest Shifflett wouldn't show up for court and asked Shepler to lower Shifflett's bond to $50,000 cash, surety or property.
Randolph County Assistant Prosecuting Attorney Shannon Johnson said the state "absolutely and strenuously" objected to any modification or reduction of bond.
"What I want to focus on today is the danger to the community that (Shifflett) represents," Johnson said. "If someone is so heinous as to molest (an underage relative), why wouldn't he molest other children?"
Johnson also initially objected to Hawkins' request for a continuance due to the stress waiting would add to the shoulders of the alleged victim, who had been prepared to testify Friday if necessary. When Shepler granted the motion for continuance, he noted that due to the alleged victim's age and relationship to Shifflett, the victim would not be permitted to testify in magistrate court.
A preliminary hearing will be scheduled for a later date.
Contact Katie Kuba by email at firstname.lastname@example.com.


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"Deep Sea Diver" (2011)
Memories of the Southern Civil Rights Movement
In the summer of 1962, Danny Lyon packed a Nikon Reflex and an old Leica in an army bag and hitchhiked south. Within a week he was in jail in Albany, Georgia, looking through the bars at another prisoner, Martin Luther King, Jr. Lyon soon became the first staff photographer for the Atlanta-based Student Nonviolent Coordinating Committee (SNCC), which already had a reputation as one of the most committed and confrontational groups fighting for civil rights.
SHADOWMAN, Bleakbeauty video #5
22 mins DVD. $33.00
"I left the cave to find reality"
Lyon's existential look at himself, filmmaking, the irony of digital, the death of film, and the meaning, if any, of documentary work. Shot in the Bernalillo graveyard (Lyon's fifth major scene shot in this spot), the New Mexico desert, the streets and garages of Manhattan, and the Maine woods.
On the last days of August, 2004 and the first days of September, New York City experienced the largest non-violent demonstrations directed against a political convention in American history. NYPD listed 120 separate protests. 1821 people were arrested. On a single day, half a million persons marched up Eighth Avenue towards the Republican National Convention in Madison Square Garden. Almost none of these protests reached the American people or the world via television.
FIVE DAYS is a documentary shot on DV by photographer Danny Lyon assisted by his twenty year old daughter Rebecca Lyon and edited by Anne Barliant, with audio mix by Jason Martin, in Kingston, New York.The 60 minute documentary, was filmed, and edited in twenty one days, and was broadcast on FreeSpeech-TV Net Work, where it had the potential to reach eight million viewers on Monday Nov. 1st the day before the election and on Tuesday, Nov. 2nd., Election Day. For a work of cinematic art and history, to be created and reach the public in a matter of weeks, is an event in itself. It is also another example of individuals, and small groups of people, working on their own and without corporate funding, or any funding for that matter, replacing the traditional media as a source of truth and news.
Five Days is full of music and features the dramatic appearance of the Infernal Noise Brigade from Seattle at the historic Fox New Protest on 6th Avenue. Later the entire band was arrested. Five Days is a testament to real democracy in action and an homage to New York City.
For Individuals: $33.00 USAFor Institutions: $100.0 USA
(Includes Universities, Museums, classroom and in-house broadcast use.)
"Born to Film" & "Two Fathers" – 2 DVD BOXED SET, Films by Danny Lyon
Born to Film, 1982 and Two Fathers, 2005 available together as a two DVD set. Born to Film is, among other things, intimately auto- biographical, interspersing footage of Lyon's own young son with film shot in the 1930's by Lyon's father, a doctor who immigrated from Germany. Two Fathers, the child star of Born To Film, Raphael, is now a twenty-seven year old who returns to his father's farm to plant corn and "experience fatherhood". A filmic meditation on life, age, family and death.


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Entrepreneurs come to USU for business lecture series
The Utah Statesman
By Marissa Neeley
The Entrepreneur Leadership Series at USU is responsible for helping interested students start and grow business, said executive director of entrepreneurial programs Mike Glauser. The program is in its third year, and it will begin on Jan. 22 and end April 9.
"We offer formal academic training and practice side of a student's education," Glauser said.
Hosted by the Jeffrey D. Clark Center for Entrepreneurship and Jon M. Huntsman School of Business, the series offers lectures from distinguished speakers throughout the spring semester.


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on November 19, 2012 - 4:41 PM
, updated November 21, 2012 at 11:34 PM
Buffalo Bills running back Fred Jackson was back on the field and practicing Wednesday afternoon, as the Bills prepared for Sunday's game at Indianapolis.
Jackson sat out last week's game against Miami with a concussion.
"They did everything they had to in order to get me cleared," Jackson said before practice. "It is a good feeling to get back out there with my teammates and try to get this thing started."
Bills coach Chan Gailey said C.J. Spiller will start at running back against the Colts.
"C.J. will start but we are still going to play Fred," Gailey said. "It takes two. It does. Fred will get quite a few snaps, but C.J. will start and get the majority of the snaps."
The Bills likely will need good production out of their running back duo.
The Colts have a productive offense, ranking fourth in the league in yards gained. The Colts' defense ranks 22nd in the league against the run and is 29th in yards per rush. Buffalo is fourth in rush average, at 5.2 yards a carry.
Meanwhile, Bills fullback Corey McIntyre left practice early due to a sore knee. Gailey said he expected McIntyre to be OK to play in the game.
Not practicing were defensive end Mark Anderson (knee), cornerbacks Aaron Williams (knee) and Ron Brooks (teeth) and defensive tackle Kyle Williams (ankle). Gailey said Brooks had an emergency dental procedure. "Hopefully he'll be back in the next day or so," Gailey said.
The Colts are in relatively good health. Defensive end Corry Redding (hip) sat out but is expected to play.
Colts offensive coordinator Bruce Arians talked to Buffalo-area reporters via conference call on how often he speaks with Colts head coach Chuck Pagano, who is on leave while battling leukemia.
"We have daily conversations, texts back and forth and talks," Arians said. "He's got all the tapes and he's watching them at home — and practices and the games. He and I talk about the team and different personnel moves. His presence is always here. His light is on in his office and will never be turned out until he comes back. That is the signal that it's his football team."
More than two dozen Bills players, coaches and staff went the Food Bank of Western New York on Tuesday to personally deliver the meals and spend time visiting with families. More than 600 families came to pick up their meals, with the other 300 meals to be delivered later. Each meal was packed to feed a family of eight to 10, and each family was pre-selected by the Food Bank.
The effort was spearheaded by Bills strength and conditioning coach John Gamble. Bills owner Ralph C. Wilson, Jr. and his wife, Mary, made a $10,000 donation to the Food Bank for the Thanksgiving drive.
Bills return man Leodis McKelvin was named AFC Special Teams Player of the Week for his performance Thursday night against the Dolphins. The first time the Bills touched the ball, McKelvin returned a punt 79 yards for a touchdown.
It was the Bills' only touchdown in a 19-14 home victory. McKelvin became the first Bills player to return a kickoff and a punt for touchdowns in the same season.
The Bills signed linebacker Greg Lloyd to the practice squad and released offensive lineman Reggie Stephens. Lloyd, the son of a former Pittsburgh Steelers linebacker of the same name, was a seventh-round pick of the Philadelphia Eagles in 2011. He's a 6-foot-1, 247-pounder from the University of Connecticut. He was released by the Colts in September.
email: firstname.lastname@example.com


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Top Definition
The act of doing something with your boys, your buds, but acting it out in the most feminine way.
Quit being a shishy wally. We needed our running back to pick up the first down, but he ran into that line like a shishy wally. Sometimes I wonder if he just wants to rub his own clit.
dari NoYouRelax Jumat, 01 April 2011
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Developers of DTC Genetic Testing Are...
As Immunotherapy Revolutionizes the Cancer Treatment...
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LC-MS Gains Favor Due To the...
A nanolipogel-based immunotherapy that simultaneously delivers both a soluble cytokine and hydrophobic small molecule growth factor inhibitor directly to tumors led to markedly reduced cancer growth in mice and increased survival, scientists report. A team at Yale University School of Medicine, and School of Engineering and Applied Sciences, has developed a biodegradable liposomal polymeric nanocarrier that combines features of both liposomal and solid polymer systems and incorporates the pharmacokinetic properties of PEGylated liposomes.
In a paper published in Nature Materials, Tarek M. Fahmy, Ph.D., Jason Park, Ph.D., and colleagues report on experiments in which the nanolipogels (nLGs) were used to deliver both a commercially available TGF-β receptor-I inhibitor SB505124 (SB) and high doses of IL-2 to mice carrying metastatic melanoma tumors. The treatment blocked the immunosuppressive effects mediated by tumor-secreted TGF-β, and enhanced the ability of IL-2 to induce activation of melanoma-specific T cell responses against the cancer. The authors claim the technology could provide the foundation for a tumor immunotherapy platform that can activate both innate and adaptive immune responses. Their published paper is titled "Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy."
Tumors secrete immunosuppressive factors that are widely believed to play a key role in dampening the immune system's ability to recognize the tumor as non-self and mount an immunological attack. In particular, signaling by tumor-secreted TGF-β has been implicated in preventing high dose IL-2 therapy from stimulating an immunological offense when used to treat cancers such as metastatic melanoma. Indeed high levels of TGF-β have been found in a large number of different tumors, including melanomas.
The Yale team's work to evaluate combining a TGF-β inhibitor with IL-2 therapy hinged on the ability to deliver both molecules simultaneously and in a sustained manner to the tumor bed. They thus needed to develop a carrier that was capable of delivering both the soluble protein cytokine and a hydrophobic small-molecule TGF-β inhibitor.
Their hybrid liposomal-polymer core-shell platform comprised a lipid bilayer surrounding a hydrogel core fabricated from a degradable polymer. The design incorporated methacrylate-conjugated cyclodextrins (CDs) into the interior of the liposomes, to allow the co-encapsulation of a protein as well as the small hydrophobic drug within the interior of the lipid bilayer.
In vivo tests showed that treating mice bearing B16 melanoma-derived tumors using intratumoral injections of the SB/IL-2-carrying nLGs resulted in a significant reduction in tumor growth rate and increased survival, when compared with treatment using either soluble SB, or SB combined with IL-2. Forty percent of the nLG-treated cohort demonstrated complete tumor regression and survived for the whole of the 60-day trial duration. Encouragingly, significant survival benefits were also evident when the dual agent-carrying nLGs were administered systemically to treat mice bearing melanoma-derived lung metastases. These treated animals also demonstrated a much lower burden of lung metastases than those given soluble SB with or without IL-2 cotherapy.
Biodistribution and localization studies using fluorescent marker-carrying nLGs demonstrated that when administered intravenously the nanoparticles traveled to sites of both distant subcutaneous tumors and metastatic lung tumors, and trafficked within the tumor vasculature, squeezing out of the leaky tumor blood vessels to reach the tumors themselves. The fact that tumor vasculature is defective and allows the nanoparticles to permeate is a major advantage, the researchers suggest. "Passive targeting can therefore result in several-fold increases in particulate concentrations in solid tumors compared to free administration of antibodies or other drugs, and may explain the increased survival and effective treatment of metastasis observed after intravenous injection."
Further studies evaluating the numbers of and types of tumor-infiltrating lymphocytes (TILs) that were recruited to tumors after different therapeutic regimens threw up interesting results. Mice treated using a combination of SB-carrying nLGs and separately administered IL-2 demonstrated increased numbers of activated CD8+ T cells in tumors, with minimal impact on overall CD4/CD8 ratios and regulatory T cells (Tregs). In contrast, treatment using nLGs that carried both SB and IL-2 resulted in substantially increased numbers of NK cells in the tumor beds, when compared with treatment using either "empty" nLGs or with particles that carried and released either IL-2 or SB alone. The key role of NK cells to the antitumor response was confirmed by the finding that in NK-depleted mice (achieved using NK antibodies), therapy using nLGs that released by SB and IL-2 didn't have a major impact on tumor mass.
"Thus, the maximum therapeutic benefit observed in mice treated with particles simultaneously delivering SB and IL-2 therapies was probably related to enhanced numbers of NK cells at the tumor site, resulting in increased effector cell populations in the tumor," the team writes. "Absence of therapeutic efficacy following NK depletion demonstrated that stimulation of the innate arm by nanoparticles releasing both agents was crucial for achieving an improvement in survival."
The Yale-based team says their results indicate that core-shell nanoparticle systems capable of simultaneously delivering two different types of immunotherapy molecule represent an attractive prospect for anticancer therapy. "This work provides an essential proof-of-concept demonstration of a biodegradable nanoparticle technology that facilitates sustained delivery of hydrophilic and hydrophobic immunomodulators to enhance anti-tumor activity against subcutaneous and metastatic melanomas," they conclude. "This therapeutic approach warrants further preclinical evaluation, as sustained delivery of immunotherapeutics such as IL-2 and SB by hybrid, core-shell, nanoparticle technology could ultimately provide a novel, clinically relevant approach to treat metastatic melanoma patients."
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