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- Report: #408284
Report - Rebuttal - Arbitrate
Complaint Review: The Fathers Choice
The Fathers Choicefatherschoice.org Goleta, California U.S.A.
The Fathers Choice I was taken advantage of. Never got representation Goleta California
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I looked like a butthole in court not having my stuff straight. I called and spoke with four different people about this and finally asked to have my money refunded. Renee', Amber and Jean all told me they would reimburst me all monies, but it could take a few weeks. I waited once more and it was never done. I tried to recently contact them, but there phone is no longer in service, and I knew I lost.
This Brian Azouz aught to be arrested and put in prision for this. This man beat other men with the easiest weapon, their children
Livingston, Louisiana
This report was posted on Ripoff Report on 01/05/2009 03:07 PM and is a permanent record located here: http://www.ripoffreport.com/r/The-Fathers-Choice/Goleta-California/The-Fathers-Choice-I-was-taken-advantage-of-Never-got-representation-Goleta-California-408284. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Biggest moments of 2012 #8. Opan Gangnam Style
- From: news.com.au
- December 12, 2012
- Korean comedian becomes worldwide superstar
- Ban Ki-moon officially relinquished title of most famous Korean to Psy
- Below: The list so far
Why did a pudgy unknown Korean bloke doing a clumsy horsey dance become the pop sensation of the year?
Because he was absolutely brilliant, that's why.
Social media helped too. One celebrity tweeted it to another, and before long, the whole world was doing the Gangnam Style horsey dance.
The clip surpassed Justin Bieber's Baby recently as the most viewed YouTube clip ever, and will likely hit one billion views any day now. It's no biggie why.
The video and song perfectly traverse a territory between parody and serious, between cool and geeky, between bubble gum K-Pop and a catchy song you'd actually dance to without a hint of irony.
For those who don't know, Gangnam is a wealthy district of the South Korean capital Seoul, where the locals, it would seem, have more than a few pretentious habits.
The whole Gangnam sensation worked so brilliantly, UN Secretary General Ban Ki-moon officially relinquished the title of "most famous Korean" to Gangnam Style creator PSY via Twitter.
Who knew the UN had a sense of humour? And who knew K-Pop was any good?
Are you the last person in the world who hasn't seen it? Click here!
Tomorrow: the anger that spread around the world and landed on our shores
In case you missed them:
14. Black Caviar takes Royal Ascot
12. Detective Chief Inspector Peter Fox, national hero
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Comments on this story
Paul B Posted at 9:51 PM December 12, 2012
Gangnam Style isn't clumsy! It's rather elegant in its own way really.

subset: commoncrawl


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Created a topic, After activating the plugin I get a Fatal Error and it does not work., on the site WordPress Support Forums
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Created a topic, Author,Email Address, Credit etc. won't show up when the form is submitted., on the site WordPress Support Forums
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Posted a reply to "Is there a way to add email and name fields to the Frontend Uploader form?", on the site WordPress Support Forums:
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N.O. tops urban school improvement list
Published: Wednesday, February 25, 2009 at 2:52 p.m.
Last Modified: Wednesday, February 25, 2009 at 2:53 p.m.
NEW ORLEANS A report released by an education think tank found 10 big-city school districts scored at or above their state averages for student achievement in 2007.
New Orleans Public Schools tops the list of districts showing the biggest improvements from 2000, according to the Brookings Institution report. But author Tom Loveless says that ranking comes with an asterisk.
He said the study used the same definition for districts as in its last report for continuity sake. But a lot has changed in New Orleans since 2000 mainly because of Hurricane Katrina.
After the 2005 storm, the New Orleans public school system retained control of a handful of the best performing schools. Loveless said schools run by charters and the state are not included in the score.
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Opened 7 years ago
Closed 7 years ago
Last modified 5 years ago
#12636 closed (duplicate)
Validation should allow excluded fields
|Reported by:
|Owned by:
|Triage Stage:
|Has patch:
|Needs documentation:
|Needs tests:
|Patch needs improvement:
|Easy pickings:
As of 1.2 alpha 1, the ModelForm validation throws an UnresolvableValidationError in the situation where a required field is excluded in the Meta subclass. I understand the intent behind that, but I believe this is broken; luckily, there is a simple way to implement it a bit differently.
Form is not the same as the Model, and ModelForm is nothing but a shortcut to create a form that follows a Model's fields. If a field is hidden from a Form, it should not evaluate it, and the Model will take care of itself: if the field in question has null=False, the Model's save() method will throw an exception anyway.
Luckily, there is already a mechanism which can help us here: blank=True is used in admin to allow a value, so I think that it should be used with regular ModelForms as well. Currently, the only way to pass the validation is that the Model field has both blank=True and null=True, but this is not what we need here: we need a mechanism to separate form validation from the model.
So I propose that only the blank attribute is validated in the ModelForm for excluded fields: if blank=True a None value is allowed for excluded fields, otherwise a UnresolvableValidationError is thrown.
Change History (3)
comment:1 Changed 7 years ago by BerislavLopac
- Needs documentation unset
- Needs tests unset
- Patch needs improvement unset
- Summary changed from Validation should skip excluded form to Validation should allow excluded fields
comment:2 Changed 7 years ago by kmtracey
- Resolution set to duplicate
- Status changed from new to closed
comment:3 Changed 5 years ago by jacob
- milestone 1.2 deleted
Milestone 1.2 deleted


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Catrina A Brucato
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Inspiring Stories About Dogs, Vol. IV
With more stories than ever before, Lost Souls: FOUND! Inspiring Stories About Dogs, Vol. IV is sure to steal your heart and take your breath away as you embark on rescue journeys with these amazing dogs. From Boston Terriers to Border Collies and Shih Tzus to Shelties, this book includes our greatest variety of "tails" to date. Don't miss this chance to take a trip around the globe and through the trials and triumphs of rescue and adoption. Get your copy today!
Excerpt: "When a malnourished Staffordshire Terrier-mix came to Friends of DeKalb Animals, the volunteers weren't sure if they could save her. Weighing less than five pounds at about four months old, she was the most severe case of neglect they had seen. A miraculous turnaround earned her the name "Xena, the Warrior Puppy," and two months after her rescue, Xena deeply connected with a young boy at a pizza party held in her honor. Soon thereafter, she went to his home on a trial visit. Xena's many fans who had been following her journey were thrilled to find out that the family felt she was a good fit, but the biggest surprise was yet to come…" –Maureen Beadles
$12.95 I 144 Pages I Find a Rescue I Preview I Meet the Authors & Dogs
Buy paperback here. eBooks available for Kindle.
The wonderful stories about adopted dogs keep rolling in, so we're rolling out Lost Souls: FOUND! Inspiring Stories About Dogs Vol. III! Like Volumes I and II, this third edition is full of fantastic, heartwarming stories about dogs who have been rescued and adopted. While a variety of stories are included, this book has a special focus on older dogs, herding-breed dogs and northern-breed dogs. (Publication date: July 2012)
Excerpt: "While searching Petfinder.com in May, I found what I considered to be a treasure: Snowy, a deaf, blind, three-year-old, double-merle Sheltie. She was residing in a shelter in Missouri, half a continent away from our home in Pennsylvania, but, despite the distance, I knew she was meant to become a member of our family. I contacted the shelter, only to find out that I was too late. Snowy was being adopted by someone who lived in – can you believe it – Pennsylvania! Hmm, what were the odds of that? In August, I was still thinking about Snowy when I received an email from Northern Chesapeake Sheltie Rescue (NCSR) about two double-merle Shelties they had recently taken in. I didn't think much about it until, later that week, I saw a post on the NCSR email list asking a question about a blind, deaf female double merle. I brushed aside the stray papers to find Snowy's picture. My eyes went immediately to her face. Could it be?" –Debbie Bauer
Learn more about the "treasure" Debbie found online and read other amazing dog rescue stories inside Lost Souls: FOUND! Inspiring Stories About Dogs Vol. II.
$12.95 I 144 Pages I Find a Rescue I Amazon Page & Preview I Meet the Authors & Dogs
Buy paperback here. eBooks available for Kindle and Nook.
Our first "all-dog" book was so much fun that we decided to do another! Similar to Vol. I, Lost Souls: FOUND! Inspiring Stories About Dogs Vol. II is an inspiring compilation about the joy adopted dogs bring to our lives. (Publication date: November 2011)
Excerpt: "Angel, a stray who had been abused before I adopted her, has really lived up to her name. I live alone and have multiple sclerosis (MS); Angel is perfect for me because we take care of each other. However, it turns out I'm not the only one she's watching out for. One night during the wee hours, Angel became restless and woke me up. I rarely go out late at night, but she seemed so anxious that I figured I should take her out. Since she stays by me either on or off the leash, I unhooked her leash so she could do what she needed to do, but instead of going back to the grass, Angel ran into the parking lot and went between two vehicles. When I caught up with Angel, I found her sitting next to one of our tenants, who was lying on the ground in a fetal position with his walker nearby…" –Jan Nashan inspiring compilation about the joy adopted dogs bring to our lives. (Publication date: November 2011)
Find out what happens in Angel's exciting story and read about many other wonderful "tails" inside Lost Souls: FOUND! Inspiring Stories About Dogs Vol. II.
$12.95 I 144 Pages I Find a Rescue I Amazon Page & Preview I Meet the Authors & Dogs
Buy paperback here. eBooks available for Kindle and Nook.
This wonderful book is Happy Tails Books' first compilation of stories about all dogs – purebred and mixed-breed of all types! (Publication date: November 2010)
Excerpt: "Wrinkles was found in a large pineapple field on the west side of Maui when he was a couple of weeks old. We adopted him, and Wrinkles fit right in with our routine. One day we were watching a friend work on my broken-down car, and when we finally looked up, Wrinkles was missing. At first we didn't believe that our dog had run away, but after searching for him everywhere around our home, we knew he was gone. We drove my husband's truck around the neighborhood looking for Wrinkles until exhaustion finally forced us to retire for the night. The next day, I was up with the sun. While readying myself to start searching again, I heard a noise outside. I walked through our back yard and noticed something moving inside my broken car. When I opened the back door, I found…" (You'll have to read the book to find out!) –Celia Lumsden
$12.95 I 144 Pages I Find a Rescue I Amazon Page & Preview I Meet the Authors & Dogs
Buy paperback here. eBooks available for Kindle and Nook.


text: Is there any plugin available that would allow an average user to change the theme of the website without logging on to the back end? I'd like to have multiple themes available so that users can choose to "customize" the interface when they visit the site. Not change the source code or CSS but just a simple click and change interface from the front end.


text:
GMA Network earned the nod of the Volunteers Against Crime and Corruption (VACC), taking home this year's Outstanding TV Station award. Read more
Gayahin ang mga bayaning inibig ang bayan nang tunay - umaasa, selfless at lumalaban! Read more
Exciting prizes are up for grabs daily and weekly in GMA News TV Panalo, the newest proof-of-purchase promo of the country's leading news channel, GMA News TV. Read more
The Board of Directors of GMA Network, Inc. unanimously elected Atty. Gilberto M. Duavit, Sr. as a Director during a meeting held last July 28 at the GMA Network Center in Quezon City. Read more
Panatilihin nating makulay at buhay ang wikang Filipino. Read more
Our August 2016 issue features GMA Network's H1 2016 financial performance on the cover. Inside stories include Atty. Felipe L. Gozon at the cover of "The CEO Magazine," Contract signing of WBR entertainment, Christian Bautista and Lovi Poe. Kapuso Abroad features Alden Richards in Singapore while Citizen Kapuso highlights GMA Kapuso Foundations "Unang Hakbang sa Kinabukasan" project and the 2016 GMA Network Excellence Award. Read more
GMA Network's financial performance continued to trend upward as it reported a net income of P2.378 billion for the first half of 2016. Read more
More Kapuso shows enter nationwide and Urban Luzon top programs lists Read more
The CEO Magazine Editor in Chief Michelle Hespe flew to Manila to personally present their latest issue to Atty. Gozon at the GMA Network Center last July 28. Read more
From among an impressive crop of candidates in the 2016 GMA Network Excellence Award (GNEA), Far Eastern University exemplary alumna Ronalyn P. Pordan was hailed as this year's winner in the Network's search for outstanding student achievers. Read more
Sama-sama nating pakinggan ang mga plano ng administrasyong Duterte live mula sa Batasang Pambansa. Ihahatid iyan ng mga pinagkakatiwalaan sa pagbabalita, ang GMA News and Public Affairs. Read more
Netizens can also follow the special coverage on www.gmanetwork.com, as well as on Twitter (@GMANews) and Facebook (facebook.com/gmanews) using the hashtag #DU30UnangSONA. Read more
Leading the Kapuso awardees is GMA News Pillar Jessica Soho, who was named as Best Magazine Show Host for the top-rating public affairs program Kapuso Mo, Jessica Soho. Read more
Upcoming GMA Telebabad program Encantadia banners the July e-Kapuso issue. Other stories include recent awards won by the Network and its personalities, Jennylyn Mercado's contract signing, new program Sinungaling Mong Puso and GMA EVP and CFO Felipe S. Yalong's birthday celebration. Kapuso Abroad features worldwide Independence Day celebrations with GMA Pinoy TV while Citizen Kapuso features GMA GIVES' Q2 Salu-Salo Together. Read more
The 3-day event only featured the best of the best in clothing lines, novelty items, beauty and skincare products, lifestyle brands, arts and crafts, and various culinary delights. Read more
According to industry metrics source Effective Measure, GMA News Online was the most viewed Filipino news website during the inauguration—garnering 7,191,930 page views on that day alone. Read more
In line with GMA's 66th Anniversary, Corporate Affairs and Communications recently held its quarterly event dubbed GMA G.I.V.E.S. (Give, Interact, Volunteer, Educate, Serve) Salu-Salo Together. It's a Corporate Social Responsibility (CSR) program that involves the Network's pool of employee volunteers. See more in this gallery. Read more
GMA Network (GMA) kept its ratings advantage in its stronghold areas of Urban Luzon and Mega Manila in June, based on data from Nielsen TV Audience Measurement, the industry's widely recognized ratings service provider. Read more
Panata sa Pagbabago received a commanding overnight audience share of 39 percent as against the 33.6 percent of ABS-CBN's Ang Panunumpa: Pangako ng Pagbabago, based on Nielsen Phils. Read more
Winners of the Reader's Digest Trusted Brand Awards were chosen based on a survey among approximately 8,000 consumers across key markets in Asia. Read more
In celebration of its 66th anniversary, the Network and its volunteers prepared surprises for the child beneficiaries of GMA Kapuso Foundation's Kapuso Cancer Champion program and Kapwa Ko, Mahal Ko's Batang K program. Read more
To stay updated on the latest news, tips and warning signs for impending disasters, visit the Network's online public safety portal, IMReady (www.imready.ph) or download the app on Google Play Store for Android devices and App Store for iOS devices. Read more
Para sa ating mga ama na laging nagpapasaya sa ating mga buhay. Happy Father's Day! Read more
GMA's 66th Anniversary program offerings banner the cover of the June 2016 Kapuso Magazine. Other features include Kapuso Mobile App, GMA's new programs Laff Camera Action and Home Foodie, Kapuso Milyonaryo 2016, etc. Kapuso Abroad features Benjamin Alves' recent Guam visit while Citizen Kapuso highlights GMAKF's relief distribution efforts in Maguindanao. Read more
Yet another milestone for Philippine TV Read more


text:
- Report: #444682
Report - Rebuttal - Arbitrate
Complaint Review: Homecomings
HomecomingsPO Box 9001719 Louisville, Kentucky U.S.A.
Wall Street Arrest Hav'nt Hit HC Crooks Yet. Plus>Homecomings Financial Is Basically A Well-organized Group Of Vulture's Fact? No Reps or loan couselors seem to acknowledge the overall housing/foreclosure crisis? Louisville Kentucky
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They see and hear how bad tha housing issue is rite now.
Of course, (8002062901) they Know millions of families have lost there homes to the same type mortgage products (arm-subprime) they are serving.
That alone reveals insight into there overall agenda. Get Paid...
Fact? When u call Homecomings (crooks) they reveal the fact they are fimiliar with OBAMA's housing plan. Right? They give all of us tha same excuse?
Excuses'-We don't know the details yet or that plan does'not apply to you.
Why? (or even how) do I know More about a stop foreclosure(s) plan put in place by tha goverment---than they do???? I'm Not dumb. They know All about tha housing plan's put in place by; OBAMA. The best President eva. They are jus waiting for the rite time to capitalize/take advantage as they do. Obviously, I to have had tha absolute worst experience's in 5 years of paying mortgage to a predatory lender.
Just as you have too. Currently we are all in a trap. Homecomings/GMAC trap.
At this point, I have sent in tha Financial analysis docs and tha foreclosure repayment plan's 3rd payment has been recieved by HC. I can read so I know I fit tha housing plan's requirements. Next Step????
Will they modify? Reduce interest rate? Will they execute the govt housing plan? Will they do anything but what they have done thru out???? I'm educated (and conditioned=BLK) enuff to NOT let my Hope's get up.
Using common sense over tha years, I always felt that HC was Doing Me something terrible, tricky mathematical interest rate increases and hidden fees that mathematically make your mortgage unpayable.
Plus, they put service agents in place to make you feel uncomfortable with the whole HC mortgage issue. A loan modification with HC is actually a forebearance-most likely your overall principal balance will increase.
Jus like many others? I currently owe more than the original sales price.
How is that? Honestly? Borrower pay 5 years on a loan and after 5 years somehow owe more than the original balance of that loan. Fact? ARM-Subprime was a trap from tha jump. The primary reason for the current recession we're in. The Broker only acted as if he was working
honestly and professionally in getting me approved for the mortgage loan. At closing, after pursuing the 2nd home purchase for six month's he changed the game plan and said I'd have to get/take a ARM to close that day.
Then later? the (mortgage leaches) HC predatory lenders got there hands on the mortgage to take full advantage.
Homecomings financial is basically a well-organized group of vulture's going around monthly---dropping in house to house eating up our monthly income with no regulations or oversight. The rich staying rich and poor stay poor agenda as usual. Wall street arrest hav'nt hit HC yet. Maybe neva will?
Glad to come across this web-site and thanks for allowing me to voice my opinion and keep my sanity.Evidently they want be helping any of us anytime soon. We must help ourselves. Any class action lawsuits? I want in. Good luck to all that's getting srewd like me/us.
Pay back is gonna be a Motha for Tha homecomings crooks.
Obviously, HC dont see it quite that way and or they don't even care.
Keep tha faith and don't go out without a fight.
Coach wms
Mobile, Alabama
This report was posted on Ripoff Report on 04/18/2009 08:34 AM and is a permanent record located here: http://www.ripoffreport.com/r/Homecomings/Louisville-Kentucky-40290/Wall-Street-Arrest-Havnt-Hit-HC-Crooks-Yet-PlusHomecomings-Financial-Is-Basically-A-Wel-444682. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Norwich - State police arrested a Norwich man Saturday who they say attempted an armed robbery of a man March 9 on the 19th floor of the Mohegan Sun hotel.
Paul E. Harris, 25, of 35 John St., was charged with attempted first-degree robbery, second-degree assault, criminal use of a firearm, carrying a pistol without a permit, attempted sixth-degree larceny and threatening.
Police said the alleged victim told police that he was assaulted by a man, later identified as Harris, after the two exited the elevator on the 19th floor around 6 a.m. March 9. The alleged victim reported he was struck from behind on the head as he walked toward his hotel room. He said he was struck again on the head and in the face by the handle of a dark colored semi-automatic handgun that the suspect displayed.
The man added that Harris allegedly demanded the money and then proceeded to hit him with the weapon in the head and face and then fled back into the elevator. Police said the victim received minor injuries and refused medical treatment.
The victim said Harris entered the hotel elevator along with him in the hotel lobby.
Troopers allege that after the assault/robbery Harris exited the elevator in the lobby of the hotel and ran on foot from the casino. A state police K-9 team tracked the suspect from the hotel but the track ended along the Thames River near Shipping Street in Norwich, north of the casino.
Police on Saturday received a tip that Harris was in Norwich. He was subsequently arrested and was held on bond, pending his arraignment today in Norwich Superior Court.
State police: Tractor-trailer struck 6 vehicles in East Lyme I-95 crash
No time to relax as Whittle's farm readies for Labor Day weekend
St. Bernard opens for 60th school year with changes underway
Judge to decide if Rhode Island inmate serving a life sentence can marry
Waterford soldier's remains come home after more than 60 years


text:
This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Courtlands Hotel3 Self rated
Courtlands Hotel 19-27 The Drive, Brighton, BN3 3JE
Price FromView Rooms
- Good
- 46 guest reviews
"We've been staying here for many years for weekend breaks. This time we arrived and were told an additional £8 for parking which is new, and..."
"Only down side was the condition of the parking area. Unkept and muddy filthy car and dirty foot marks everywhere...."
"Very friendly and welcoming staff at the hotel very helpful value for money would stay there again..."
"Stayed in (family) room 222 with elderly parents - which has a main room comprising of a queen size bed, and a separate room with two single..."
About the hotel
*'More than a hotel; The Courtlands is an iconic piece of Hove's history,stretched contentedly along a prestigious tree-lined avenue within a short walk of the famous promenade and shingle seafront. * *Quietly grand by nature, this is understated splendour and restful style,with friendly and professional service. * *We offer comfortable accommodation with style; each of our sixty-six en suite rooms are different – some traditional, with an eclectic mix of beautiful and authentic antique furniture, some contemporary with chic and minimal style – whether old or new, each room has complimentary wifi.
. . '*
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- Hotel Non-Smoking Throughout , Disabled Facilities
- Hotel services
- 24 Hour Reception , Limited Hours Room Service , Laundry/Valet Service , Wake Up Call Available , Currency Exchange
- Family friendly
- Cots available
- Parking (charges may apply)
- Car parking available onsite
- Business
- Wi-Fi Available , Meeting Facilities , Wi-Fi Available In Public Areas , Wi-Fi Available In Rooms , Private dining services
- Dining
- Restaurant , Bar
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- In room facilities
- Tea/Coffee making facilities in each room , Hairdryer in each room , Telephone In Each Room
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- From 14:00 hours
- Until 11:00 hours
- 10/04/2015 to 06/09/2024 - The Hotel secure private car park is available to guests at an extra charge of £10.00 per night per car The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are not allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
65% would recommend it to a friend
Customer service
Food quality
Room quality
Very grim small room, needs total overhaul.
Windows should be replaced, wallpaper there since the seventies. Thankfully it was just 1 night.
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Been staying here for years, policies recently changed - unlikely to stay again
We've been staying here for many years for weekend breaks.
This time we arrived and were told an additional £8 for parking which is new, and unexpected, even though yes its on the terms and conditions. Nothing they could do
Also, late checkouts now attract a £10 per hour fee, which was unexpected again. The hotel is okay, the feel of the place has changed though and I don't think we'll stay again. Its not cheap and I felt unvalued.
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text:
WASHINGTONVILLE — A Washingtonville man was arrested Saturday evening after, police said, he crashed into a fire truck while driving drunk.
Village police said the fire truck was responding to a brush fire on Lincolndale Acres in New Windsor, with emergency lights and sirens on. John Cavalari Sr., 68, pulled his vehicle to the right side to let the fire truck pass, then turned left into the fire truck's path and hit its side.
There were five firefighters on the truck. Nobody was hurt. Cavalari's vehicle was heavily damaged; the fire truck sustained minor damage.
Police said Cavalari's blood-alcohol content was .12. He was charged with felony drunken driving due to three prior convictions for alcohol-related offenses, and also issued three traffic tickets. He was released on $500 bail to appear in village court at a later date.
Nathan Brown
Location, ST | website.com


text:
Kent State currently employs 5,019 students, many of whom are gaining real-world experience in their field of study.
Kent State's University Library is nationally recognized and is among the best in the world.
Kent State students received more than $54 million in scholarships, offered in 2015-2016.
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Kent State has more than 350 student clubs to choose from! Finding a student organization to join is easy.
Kent State's Holly Speers broke the NCAA record for consecutive home runs this season and is nearing additional NCAA Division I records.
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Gov. John Kasich has appointed Carly Evans to a two-year term as an undergraduate student trustee of the Kent State University Board of Trustees. Evans' term concludes on May 16, 2018.
Ohio Gov. John Kasich has appointed a new trustee to the Kent State University Board of Trustees. Kasich named Shawn M. Riley of Gates Mills, Ohio, to a nine-year term as a trustee. Riley's appointment began May 17, 2016, and ends May 16, 2025.
Dr. Beverly Warren will remain president of Kent State University through at least 2020. On May 11, the Kent State University Board of Trustees voted to extend Warren's employment agreement through June 30, 2020.
"Kent State has developed tremendous momentum under President Bev Warren's exceptional leadership," said Dennis Eckart, chair of the Kent State Board of Trustees. "Extending Bev's contract expresses our strong confidence in her leadership and the university's direction. She is critical in enabling us to meet our key goals going forward."
The Kent State University Board of Trustees will hold its next regular business meeting Wednesday, May 11. The Board is scheduled to convene at 9 a.m. in the Event Space on the first floor of the university's new Center for Philanthropy and Alumni Engagement, located at 350 S. Lincoln St. in Kent, Ohio.
Trustees will retire into executive session from 7:30-8:45 a.m. in the Board Room on the third floor to consider specific topics as provided for under Ohio's "Sunshine Law."
Ohio Gov. John Kasich has appointed a new trustee to the Kent State University Board of Trustees. Kasich named Robin Kilbride of Wadsworth, Ohio, to a nine-year term as a trustee. Kilbride's appointment began April 18, 2016, and ends May 16, 2024.
Kent State University is mourning the loss of a valued member of its family. Trustee Richard H. Marsh passed away March 24.
Kent State University Board of Trustees approved establishing a unified student government across all campuses – Ashtabula, East Liverpool, Geauga, Kent, Salem, Stark, Trumbull and Tuscarawas – during its March 9, 2016, board meeting.
Each campus' Undergraduate Student Government is recognized as the representative voice of the students' interests, concerns and needs. Elected presidents from each campus will serve as the liaison between the student body, Undergraduate Student Government and university administration.
The Kent State University Board of Trustees will hold its next regular business meeting Wednesday, March 9. The Board is scheduled to convene at 2:45 p.m. in the Riviera Ballroom B, first level of Aloft Cleveland Downtown, located at 1111 West 10th St., Cleveland, Ohio.
Trustees will retire into executive session/working lunch from noon-1:15 p.m. in the Tactic Room to consider specific topics as provided for under Ohio's "Sunshine Law."
Board committees will meet as follows:
UPDATED JAN. 25, 2016: AAUP-KSU's membership have voted and ratified the new contract. With approval by both the Board of Trustees and the AAUP-KSU, the ratification process is complete. The successor collective bargaining agreement with the tenured and tenure-track faculty is effective Aug. 19, 2015, through Aug. 18, 2018.
The Kent State University Board of Trustees will hold a special meeting Wednesday, Jan. 20, for the sole purpose of ratifying a three-year, collective bargaining agreement between the university and full-time, tenured and tenure-track faculty, who are represented by the American Association of University Professors-Kent State Chapter.
The Board will convene at 5:45 p.m. in the George Urban Board of Trustees Conference Room, which is located on the second floor of the Kent Campus Library.


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RECALL for Replacement: Petzl GriGri 2added Jun/2011, see all Petzl news & reviews
Product news by Lyon Outdoor
Petzl is not aware of any accidents resulting from this but has increased the mechanical strength of the handle on all GriGri 2s since serial number 11137.
Petzl is sending Lyon Equipment new production of GRIGRI 2's to allow replacement of those currently in use in the UK and Ireland.
If you are in the UK or Ireland you are asked to stop using the GriGri 2 and to send it, for replacement to Lyon Equipment Ltd. Full details are available by following links at www.lyon-outdoor.co.uk or by emailing email@example.com.
Please follow the links on www.lyon-outdoor.co.uk for information on how to get your replacement GriGri2 as quickly and efficiently as possible. These instructions are also below.
You are asked to stop using the GRIGRI 2 and to send it for replacement to;
After Sales Department (UK & Ireland) GRIGRI 2
Lyon Equipment Ltd.
Junction 38,
M6 Tebay
Cumbria CA10 3SS
Phone: 015396 25944 (GRIGRI only)
Email: email@example.com
We will replace your GRIGRI 2 with the same colour. If you are happy to accept an alternative colour please let us know in writing with your return. If we are temporarily out of a particular colour, and know an alternative is acceptable it enables us to provide the fastest replacement service to you.
For any service other than replacement please contact the retailer you purchased from.
Lyon Equipment is unable to provide a refund. This does not affect your statutory rights.
There are 4 ways you can return your GRIGRI 2 for replacement;
A. Post it yourself � we will refund up to £6.50 postage.
B. Collection from a business address � please pack ready for collection, the carrier will have an address label and collect during business hours. A signature is required. Please send details (including contact phone number) for the collection to email@example.com.
C. Pre-paid envelope - send your name, and postal address to email@example.com advising us how many GriGri 2's you have, and we will send you an addressed, pre-paid plastic envelope so you can post it to us.
D. Return to the retailer you purchased the GriGri 2 from so they can forward it to us.
NB. It is essential that you include contact details with any returned items;
Phone number
Email address
Return postal address (this is a parcel - we require an address where someone can sign for the parcel, for example a work address.)
Please accept our apologies for this inconvenience. We will resolve this as quickly and efficiently as possible.
Jonathan Capper.
Managing Director
For and on behalf of Lyon Equipment Ltd
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Gear News and Outdoor Industry News at UKC and UKH presents climbing, walking and mountaineering equipment and stories that will be of interest to UKClimbing.com's readers. They are not gear reviews and are provided by companies that advertise with UKClimbing Limited. Please feel free to comment about the stories and products on the associated thread.


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Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O.
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter.
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.
The chemical reactions and pathways involving a reactive nitrogen species.
Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


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Most Cited Molecular Oncology Articles
The most cited articles published since 2011, extracted from Scopus.
Deconstructing the molecular portraits of breast cancerAleix Prat | Charles M. Perou
Volume 5, Issue 1, February 2011, Pages 5-23
Breast cancer is a heterogeneous disease in terms of histology, therapeutic response, dissemination patterns to distant sites, and patient outcomes. Global gene expression analyses using high-throughput technologies have helped to explain much of this heterogeneity and provided important new classifications of cancer patients. In the last decade, genomic studies have established five breast cancer intrinsic subtypes (Luminal A, Luminal B, HER2-enriched, Claudin-low, Basal-like) and a Normal Breast-like group. In this review, we dissect the most recent data on this genomic classification of breast cancer with a special focus on the Claudin-low subtype, which appears enriched for mesenchymal and stem cell features. In addition, we discuss how the combination of standard clinical-pathological markers with the information provided by these genomic entities might help further understand the biological complexity of this disease, increase the efficacy of current and novel therapies, and ultimately improve outcomes for breast cancer patients. © 2010 Federation of European Biochemical Societies.
MicroRNA and cancerMartin D. Jansson | Anders H. Lund
Volume 6, Issue 6, December 2012, Pages 590-610
With the advent of next generation sequencing techniques a previously unknown world of non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely outnumber the group of protein coding sequences and hold promise of many new discoveries and mechanistic explanations for essential biological phenomena and pathologies. The best characterized non-coding RNA family consists in humans of about 1400 microRNAs for which abundant evidence have demonstrated fundamental importance in normal development, differentiation, growth control and in human diseases such as cancer. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs in cancer, which have emerged from the study of cell culture and animal model systems, including the regulation of key cancer-related pathways, such as cell cycle control and the DNA damage response. Importantly, microRNA molecules are already entering the clinic as diagnostic and prognostic biomarkers for patient stratification and also as therapeutic targets and agents. © 2012 Federation of European Biochemical Societies.
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandingsThomas Helleday
Volume 5, Issue 4, August 2011, Pages 387-393
Poly (ADP-ribose) polymerase (PARP) inhibitors effectively kill tumours defective in the BRCA1 or BRCA2 genes through the concept of synthetic lethality. It is suggested that PARP inhibitors cause an increase in DNA single-strand breaks (SSBs), which are converted during replication to irreparable toxic DNA double-strand breaks (DSBs) in BRCA1/2 defective cells. There are a number of recent reports challenging this model. Here, alternative models that are not mutually exclusive are presented to explain the synthetic lethality between BRCA1/2 and PARP inhibitors. One such model proposes that PARP inhibition causes PARP-1 to be trapped onto DNA repair intermediates, especially during base excision repair. This may in turn cause obstruction to replication forks, which require BRCA-dependent homologous recombination to be resolved. In another model, PARP is directly involved in catalysing replication repair in a distinct pathway from homologous recombination. Experimental evidence supporting these novel models to explain the PARP-BRCA synthetic lethality are discussed. © 2011 Federation of European Biochemical Societies.
Histone deacetylases and cancerBruna Barneda-Zahonero | Maribel Parra
Volume 6, Issue 6, December 2012, Pages 579-589
Reversible acetylation of histone and non-histone proteins is one of the most abundant post-translational modifications in eukaryotic cells. Protein acetylation and deacetylation are achieved by the antagonistic actions of two families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). Aberrant protein acetylation, particularly on histones, has been related to cancer while abnormal expression of HDACs has been found in a broad range of cancer types. Therefore, HDACs have emerged as promising targets in cancer therapeutics, and the development of HDAC inhibitors (HDIs), a rapidly evolving area of clinical research. However, the contributions of specific HDACs to a given cancer type remain incompletely understood. The aim of this review is to summarize the current knowledge concerning the role of HDACs in cancer with special emphasis on what we have learned from the analysis of patient samples. © 2012 Federation of European Biochemical Societies.
HDAC inhibitor-based therapies: Can we interpret the code?Maria New | Heidi Olzscha | Nicholas B. La Thangue
Volume 6, Issue 6, December 2012, Pages 637-656
Abnormal epigenetic control is a common early event in tumour progression, and aberrant acetylation in particular has been implicated in tumourigenesis. One of the most promising approaches towards drugs that modulate epigenetic processes has been seen in the development of inhibitors of histone deacetylases (HDACs). HDACs regulate the acetylation of histones in nucleosomes, which mediates changes in chromatin conformation, leading to regulation of gene expression. HDACs also regulate the acetylation status of a variety of other non-histone substrates, including key tumour suppressor proteins and oncogenes. Histone deacetylase inhibitors (HDIs) are potent anti-proliferative agents which modulate acetylation by targeting histone deacetylases. Interest is increasing in HDI-based therapies and so far, two HDIs, vorinostat (SAHA) and romidepsin (FK228), have been approved for treating cutaneous T-cell lymphoma (CTCL). Others are undergoing clinical trials. Treatment with HDIs prompts tumour cells to undergo apoptosis, and cell-based studies have shown a number of other outcomes to result from HDI treatment, including cell-cycle arrest, cell differentiation, anti-angiogenesis and autophagy. However, our understanding of the key pathways through which HDAC inhibitors affect tumour cell growth remains incomplete, which has hampered progress in identifying malignancies other than CTCL which are likely to respond to HDI treatment. © 2012 Federation of European Biochemical Societies.
Discovery of small molecule cancer drugs: Successes, challenges and opportunitiesSwen Hoelder | Paul A. Clarke | Paul Workman
Volume 6, Issue 2, April 2012, Pages 155-176
The discovery and development of small molecule cancer drugs has been revolutionised over the last decade. Most notably, we have moved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a personalised medicine strategy that focuses on the discovery and development of molecularly targeted drugs that exploit the particular genetic addictions, dependencies and vulnerabilities of cancer cells. These exploitable characteristics are increasingly being revealed by our expanding understanding of the abnormal biology and genetics of cancer cells, accelerated by cancer genome sequencing and other high-throughput genome-wide campaigns, including functional screens using RNA interference. In this review we provide an overview of contemporary approaches to the discovery of small molecule cancer drugs, highlighting successes, current challenges and future opportunities. We focus in particular on four key steps: Target validation and selection; chemical hit and lead generation; lead optimization to identify a clinical drug candidate; and finally hypothesis-driven, biomarker-led clinical trials. Although all of these steps are critical, we view target validation and selection and the conduct of biology-directed clinical trials as especially important areas upon which to focus to speed progress from gene to drug and to reduce the unacceptably high attrition rate during clinical development. Other challenges include expanding the envelope of druggability for less tractable targets, understanding and overcoming drug resistance, and designing intelligent and effective drug combinations. We discuss not only scientific and technical challenges, but also the assessment and mitigation of risks as well as organizational, cultural and funding problems for cancer drug discovery and development, together with solutions to overcome the 'Valley of Death' between basic research and approved medicines. We envisage a future in which addressing these challenges will enhance our rapid progress towards truly personalised medicine for cancer patients. © 2012 Federation of European Biochemical Societies.
Trials with 'epigenetic' drugs: An updateAngela Nebbioso | Vincenzo Carafa | Rosaria Benedetti | Lucia Altucci
Volume 6, Issue 6, December 2012, Pages 657-682
Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk between DNA methylation, histone modifications and non-coding RNAs, affect gene expression and are associated with disease progression. In contrast to genetic mutations, epigenetic changes are potentially reversible. Re-expression of genes epigenetically inactivated can result in the suppression of disease state or sensitization to specific therapies. Small molecules that reverse epigenetic inactivation, so-called epi-drugs, are now undergoing clinical trials. Accordingly, the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for cancer treatment have approved some of these drugs. Here, we focus on the biological features of epigenetic molecules, analyzing the mechanism(s) of action and their current use in clinical practice. © 2012 Federation of European Biochemical Societies.
DNA methylation and microRNA dysregulation in cancerHiromu Suzuki | Reo Maruyama | Eiichiro Yamamoto | Masahiro Kai
Volume 6, Issue 6, December 2012, Pages 567-578
DNA methylation plays a key role in the silencing of numerous cancer-related genes, thereby affecting a number of vital cellular processes, including the cell cycle checkpoint, apoptosis, signal transduction, cell adhesion and angiogenesis. Also widely altered in human malignancies is the expression of microRNAs (miRNAs), a class of small noncoding RNAs that act as posttranscriptional regulators of gene expression. Furthermore, emerging evidence now supports the idea that DNA methylation is crucially involved in the dysregulation of miRNAs in cancer. This is in part the result of technological advances that enable more comprehensive analysis of miRNA expression profiles and the epigenome in cancer cells, which has led to the identification of a number of epigenetically regulated miRNAs. As with protein-coding genes, it appears that miRNA genes involved in regulating cancer-related pathways are silenced in association with CpG island hypermethylation. In addition, methylation in CpG island shore regions and DNA hypomethylation also appear to contribute to miRNA dysregulation in cancer. Aberrant DNA methylation of miRNA genes is a potentially useful biomarker for detecting cancer and predicting its outcome. Moreover, re-expression of miRNAs and the replacement of tumor suppressive miRNAs using miRNA mimics or expression vectors could be effective approaches to cancer therapy. © 2012 Federation of European Biochemical Societies.
The biology of cancer testis antigens: Putative function, regulation and therapeutic potentialElisabetta Fratta | Sandra Coral | Alessia Covre | Giulia Parisi | Francesca Colizzi | Riccardo Danielli | Hugues Jean Marie Nicolay | Luca Sigalotti | Michele Maio
Volume 5, Issue 2, April 2011, Pages 164-182
Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues except for testis and placenta. This tumor-restricted pattern of expression, together with their strong in vivo immunogenicity, identified CTA as ideal targets for tumor-specific immunotherapeutic approaches, and prompted the development of several clinical trials of CTA-based vaccine therapy. Driven by this practical clinical interest, a more detailed characterization of CTA biology has been recently undertaken. So far, at least 70 families of CTA, globally accounting for about 140 members, have been identified. Most of these CTA are expressed during spermatogenesis, but their function is still largely unknown. Epigenetic events, particularly DNA methylation, appear to be the primary mechanism regulating CTA expression in both normal and transformed cells, as well as in cancer stem cells. In view of the growing interest in CTA biology, the aim of this review is to provide the most recent information on their expression, regulation and function, together with a brief summary of the major clinical trials involving CTA as therapeutic agents. The pharmacologic modulation of CTA expression profiles on neoplastic cells by DNA hypomethylating drugs will also be discussed as a feasible approach to design new combination therapies potentially able to improve the clinical efficacy of currently adopted CTA-based immunotherapeutic regimens in cancer patients. © 2011 Federation of European Biochemical Societies.
Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugsLuis I. Toledo | Matilde Murga | Oscar Fernandez-Capetillo
Volume 5, Issue 4, August 2011, Pages 368-373
Trying to kill cancer cells by generating DNA damage is by no means a new idea. Radiotherapy and genotoxic drugs are routinely used in cancer therapy. More recent developments also explored the potential of targeting the DNA damage response (DDR) in order to increase the toxicity of radio- and chemo- therapy. Chk1 inhibitors have pioneered studies in this regard. Interestingly, early studies noted that Chk1 inhibitors were particularly toxic for p53-deficient cells. The model proposed for this observation was that this effect was due to the simultaneous abrogation of the G2 (Chk1) and G1 (p53) checkpoints. We here challenge this view, and propose a model where the toxicity of Chk1 inhibitors is rather due to the fact that these compounds generate high loads of replicative stress (RS) during S-phase, which are further boosted by the less restrictive S-phase entry found in p53-deficient cells. This new model implies that the particular toxicity of Chk1 inhibitors might not be restricted to p53-deficient cells, but could be extended to other mutations that promote a promiscuous S-phase entry. In addition, this rationale also implies that the same effect should also be observed for other molecules that target the RS-response (RSR), such as inhibitors of the Chk1-activating kinase ATR. © 2011 Federation of European Biochemical Societies.
Methylation profiling with a panel of cancer related genes: Association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancerJo Anders Rønneberg | Thomas Fleischer | Hiroko Kato Solvang | Silje H. Nordgard | Hege Edvardsen | Ivan Potapenko | Daniel Nebdal | Christian Daviaud | Ivo Gut | Ida Bukholm | Bjørn Naume | Anne Lise Børresen-Dale | Jörg Tost | Vessela Kristensen
Volume 5, Issue 1, February 2011, Pages 61-76
Breast cancer is a heterogeneous disease that can be divided in subtypes based on histology, gene expression profiles as well as differences in genomic aberrations. Distinct global DNA methylation profiles have been reported in normal breast epithelial cells as well as in breast tumors. However, the influence of the tumor methylome on the previously described subgroups of breast cancer is not fully understood. Here we report the DNA methylation profiles of 80 breast tumors using a panel of 807 cancer related genes interrogating 1505 CpG sites. We identified three major clusters based on the methylation profiles; one consisting of mainly tumors of myoepithelial origin and two other clusters with tumors of predominantly luminal epithelial origin. The clusters were different with respect to estrogen receptor status, TP53 status, ErbB2 status and grade. The most significantly differentially methylated genes including HDAC1, TFF1, OGG1, BMP3, FZD9 and HOXA11 were confirmed by pyrosequencing. Gene Ontology analysis revealed enrichment for genes involved in developmental processes including homeobox domain genes (HOXA9, HOXA11, PAX6, MYBL2, ISL1 and IPF1) and (ETS1, HDAC1, CREBBP, GAS7, SPI1 and TBX1). Extensive correlation to mRNA expression was observed. Pathway analyses identified a significant association with canonical (curated) pathways such as hepatic fibrosis including genes like EGF, NGFR and TNF, dendritic cell maturation and the NF-κB signaling pathway. Our results show that breast tumor expression subtypes harbor major epigenetic differences and tumors with similar gene expression profiles might belong to epigenetically different subtypes. Some of the transcription factors identified, with key roles in differentiation and development might play a role in inducing and maintaining the different phenotypes. © 2010 Federation of European Biochemical Societies.
Cancer biomarkersN. Lynn Henry | Daniel F. Hayes
Volume 6, Issue 2, April 2012, Pages 140-146
Biomarkers have many potential applications in oncology, including risk assessment, screening, differential diagnosis, determination of prognosis, prediction of response to treatment, and monitoring of progression of disease. Because of the critical role that biomarkers play at all stages of disease, it is important that they undergo rigorous evaluation, including analytical validation, clinical validation, and assessment of clinical utility, prior to incorporation into routine clinical care. In this review we address key steps in the development of biomarkers, including ways to avoid introducing bias and guidelines to follow when reporting results of biomarker studies. © 2012 Federation of European Biochemical Societies.
P53: Guardian of ploidyYael Aylon | Moshe Oren
Volume 5, Issue 4, August 2011, Pages 315-323
Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression. True to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either instigating irreversible cell cycle arrest or apoptosis. The tumor suppressor Lats2, along with other tumor inhibitory proteins such as BRCA1/2 and BubR1, are central to p53-dependent elimination of tetraploid cells. Not surprisingly, these proteins are frequently inactivated or downregulated in tumors, synergizing with p53 inactivation to establish an atmosphere of " tolerance" for a non-diploid state. © 2011 Federation of European Biochemical Societies.
Oncosuppressive role of p53-induced miR-205 in triple negative breast cancerClaudia Piovan | Dario Palmieri | Gianpiero Di Leva | Luca Braccioli | Patrizia Casalini | Gerard Nuovo | Monica Tortoreto | Marianna Sasso | Ilaria Plantamura | Tiziana Triulzi | Cristian Taccioli | Elda Tagliabue | Marilena V. Iorio | Carlo M. Croce
Volume 6, Issue 4, August 2012, Pages 458-472
An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53.Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration. © 2012.
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variablesSitharthan Kamalakaran | Vinay Varadan | Hege E. Giercksky Russnes | Dan Levy | Jude Kendall | Angel Janevski | Michael Riggs | Nilanjana Banerjee | Marit Synnestvedt | Ellen Schlichting | Rolf Kåresen | K. Shama Prasada | Harish Rotti | Ramachandra Rao | Laxmi Rao | Man Hung Eric Tang | K. Satyamoorthy | Robert Lucito | Michael Wigler | Nevenka Dimitrova | Bjorn Naume | Anne Lise Borresen-Dale | James B. Hicks
Volume 5, Issue 1, February 2011, Pages 77-92
The diversity of breast cancers reflects variations in underlying biology and affects the clinical implications for patients. Gene expression studies have identified five major subtypes- Luminal A, Luminal B, basal-like, ErbB2+ and Normal-Like. We set out to determine the role of DNA methylation in subtypes by performing genome-wide scans of CpG methylation in breast cancer samples with known expression-based subtypes. Unsupervised hierarchical clustering using a set of most varying loci clustered the tumors into a Luminal A majority (82%) cluster, Basal-like/ErbB2+ majority (86%) cluster and a non-specific cluster with samples that were also inconclusive in their expression-based subtype correlations. Contributing methylation loci were both gene associated loci (30%) and non-gene associated (70%), suggesting subtype dependant genome-wide alterations in the methylation landscape. The methylation patterns of significant differentially methylated genes in luminal A tumors are similar to those identified in CD24 + luminal epithelial cells and the patterns in basal-like tumors similar to CD44 + breast progenitor cells. CpG islands in the HOXA cluster and other homeobox (IRX2, DLX2, NKX2-2) genes were significantly more methylated in Luminal A tumors. A significant number of genes (2853, p < 0.05) exhibited expression-methylation correlation, implying possible functional effects of methylation on gene expression. Furthermore, analysis of these tumors by using follow-up survival data identified differential methylation of islands proximal to genes involved in Cell Cycle and Proliferation (Ki-67, UBE2C, KIF2C, HDAC4), angiogenesis (VEGF, BTG1, KLF5), cell fate commitment (SPRY1, OLIG2, LHX2 and LHX5) as having prognostic value independent of subtypes and other clinical factors. © 2010 Federation of European Biochemical Societies.
Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancerCarina Roth | Sabine Kasimir-Bauer | Klaus Pantel | Heidi Schwarzenbach
Volume 5, Issue 3, June 2011, Pages 281-291
The focus of the current investigational study was to examine whether circulating nucleic acids (i.e., DNA and microRNAs) have the potential to become suitable blood-based markers for diagnosis and progression of lung cancer. The concentrations of cell-free DNA and four circulating microRNAs (miR10b, miR34a, miR141 and miR155) as well as the caspase activity were measured in serum of 35 lung cancer patients (19 non-small-cell lung cancer, 8 small cell lung cancer patients and 8 patients with indefinite cancer type), 7 patients with benign lung tumors and 28 healthy individuals by PicoGreen, TaqMan MicroRNA, and Caspase-Glo®3/7 assay, respectively. The data were correlated with the established risk factors for lung cancer progression. The concentrations of cell-free DNA (p = 0.0001), serum microRNAs (p = 0.0001) and caspase activities (p = 0.0001) significantly discriminated cancer patients from healthy individuals. Serum DNA, caspase activities and RNA levels could not distinguish between patients with benign lung disease and cancer patients. However, the levels of miR10b (p = 0.002), miR141 (p = 0.0001) and miR155 (p = 0.007) were significantly higher in lung cancer patients than those in patients with benign disease. As determined by the Spearman-Rho test, high levels of cell-free DNA significantly correlated with elevated circulating caspase activities (p = 0.0001). In lung cancer patients high serum miR10b values associated with lymph node metastasis (p < 0.03) and elevated levels of TPA (tissue polypeptide antigen, p = 0.01), whereas high serum miR141 values associated with elevated levels of uPA (urokinase plasminogen activator, p = 0.02).The findings of our pilot study suggest that the assays for circulating DNA, microRNAs and caspase activities in blood might become novel minimally invasive diagnostic tools for detection and risk assessment of lung cancer, provided that their clinical utility can be confirmed in larger prospective trials. © 2011 Federation of European Biochemical Societies.
Tumour heterogeneity and the evolution of polyclonal drug resistanceRebecca A. Burrell | Charles Swanton
Volume 8, Issue 6, January 2014, Pages 1095-1111
© 2014 Federation of European Biochemical Societies.Cancer drug resistance is a major problem, with the majority of patients with metastatic disease ultimately developing multidrug resistance and succumbing to their disease. Our understanding of molecular events underpinning treatment failure has been enhanced by new genomic technologies and pre-clinical studies. Intratumour genetic heterogeneity (ITH) is a prominent contributor to therapeutic failure, and it is becoming increasingly apparent that individual tumours may achieve resistance via multiple routes simultaneously - termed polyclonal resistance. Efforts to target single resistance mechanisms to overcome therapeutic failure may therefore yield only limited success. Clinical studies with sequential analysis of tumour material are needed to enhance our understanding of inter-clonal functional relationships and tumour evolution during therapy, and to improve drug development strategies in cancer medicine.
MiRNA expression profiling of mycosis fungoidesMarloes S. van Kester | Erica Ballabio | Marchina F. Benner | Xiao H. Chen | Nigel J. Saunders | Leslie van der Fits | Remco van Doorn | Maarten H. Vermeer | Rein Willemze | Cornelis P. Tensen | Charles H. Lawrie
Volume 5, Issue 3, June 2011, Pages 273-280
MicroRNAs (miRNAs) are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many malignancies including lymphoma. However, the role of miRNAs in the pathogenesis of T-cell lymphoid malignancies is poorly understood. Previously we examined the miRNA profile of Sézary syndrome (Sz), a leukemia of skin-homing memory T cells. In this study we determined the complete miRNome of mycosis fungoides (MF), the most common type of cutaneous T cell lymphoma. The miRNA profile of skin biopsies from 19 patients with tumor stage MF and 12 patients with benign inflammatory dermatoses (eczema and lichen planus) were compared by microarray analysis. We identified 49 miRNAs that are differentially expressed in tumor stage MF compared to benign inflammatory dermatoses using ANOVA analysis (P < 0.05, Benjamini-Hochberg corrected). The majority of the differentially expressed miRNAs (30/49) were up-regulated in tumor stage MF. The most significant differentially expressed were miR-155 and miR-92a (both up-regulated in tumor stage MF), while miR-93 showed the highest up-regulation in tumor stage MF with a fold difference of 5.8. Differential expression of a selection of these miRNAs was validated by miRNA-Q-PCR on additional test groups (tumors and controls). None of the miRNAs up-regulated in tumor stage MF was previously shown to be up-regulated in Sz, and only 2 of the 19 miRNAs down-regulated in tumor stage MF were also down-regulated in Sz. Taken together this report is the first describing the miRNA signature of tumor stage MF. © 2011 Federation of European Biochemical Societies.
The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilitiesMichele De Palma | Douglas Hanahan
Volume 6, Issue 2, April 2012, Pages 111-127
It is a time of great promise and expectation for the applications of knowledge about mechanisms of cancer toward more effective and enduring therapies for human disease. Conceptualizations such as the hallmarks of cancer are providing an organizing principle with which to distill and rationalize the abject complexities of cancer phenotypes and genotypes across the spectrum of the human disease. A countervailing reality, however, involves the variable and often transitory responses to most mechanism-based targeted therapies, returning full circle to the complexity, arguing that the unique biology and genetics of a patient's tumor will in the future necessarily need to be incorporated into the decisions about optimal treatment strategies, the frontier of personalized cancer medicine. This perspective highlights considerations, metrics, and methods that may prove instrumental in charting the landscape of evaluating individual tumors so to better inform diagnosis, prognosis, and therapy. Integral to the consideration is remarkable heterogeneity and variability, evidently embedded in cancer cells, but likely also in the cell types composing the supportive and interactive stroma of the tumor microenvironment (e.g., leukocytes and fibroblasts), whose diversity in form, regulation, function, and abundance may prove to rival that of the cancer cells themselves. By comprehensively interrogating both parenchyma and stroma of patients' cancers with a suite of parametric tools, the promise of mechanism-based therapy may truly be realized. © 2012 Federation of European Biochemical Societies.
Identification of recurrence-related microRNAs in hepatocellular carcinoma following liver transplantationZhong Bo Han | Lin Zhong | Mu Jian Teng | Jun Wei Fan | Hua Mei Tang | Jun Yi Wu | Hong Yuan Chen | Zhao Wen Wang | Guo Qiang Qiu | Zhi Hai Peng
Volume 6, Issue 4, August 2012, Pages 445-457
Tumor recurrence-related microRNAs (miRNAs) in hepatocellular carcinoma (HCC) following orthotopic liver transplantation (OLT) are not clear yet. This study was designed to determine whether altered miRNA expression is associated with HCC recurrence and prognosis following OLT. 18 miRNAs, including 6 up-regulated and 12 down-regulated miRNAs were identified by microarray in primary HCC samples of patients who had developed HCC recurrence (n = 5) compared to those with non-recurrence (n = 5) following OLT by using p < 0.05 as cutoff value. The six most significantly altered miRNAs (fold change ≥ 2: miR-19a, miR-886-5p, miR-126, miR-223, miR-24 and miR-147) were further confirmed by qRT-PCR in the remaining 105 HCC samples. In receiver-operating characteristic curve analysis, this six miRNAs were of high sensitivity and specificity in predicting HCC recurrence. Using Cox regression and risk score analysis, we built a six-miRNA signature based on their qRT-PCR readings for the prediction of outcome of HCC following OLT. Kaplan-Meier and Cox proportional regression revealed this six-miRNA signature was a significant independent predictor of overall survival (log-rank p = 0.020) and recurrence-free survival (log-rank p < 0.001). Finally, the data were further reconfirmed in an independent cohort of 50 patients from another transplant center. In addition, bioinformatics Gene Ontology and pathway analysis were also performed to better understand the critical roles of these miRNAs in HCC recurrence. Our study, in addition to suggesting a different miRNA expression pattern between HCC samples of patients with recurrence and those with non-recurrence, proposes that this six-miRNA signature may serve as biomarker for prognosis of HCC patients following OLT. © 2012 Federation of European Biochemical Societies.
The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasLPeng Wang | Liping Zhuang | Juan Zhang | Jie Fan | Jianmin Luo | Hao Chen | Kun Wang | Luming Liu | Zhen Chen | Zhiqiang Meng
Volume 7, Issue 3, June 2013, Pages 334-345
miR-21 expression in cancer tissue has been reported to be associated with the clinical outcome and activity of gemcitabine in pancreatic cancer. However, resection is possible in only a minority of patients due to the advanced stages often present at the time of diagnosis, and safely obtaining sufficient quantities of pancreatic tumor tissue for molecular analysis is difficult at the unresectable stages. In this study, we investigated whether the serum level of miR-21 could be used as a predictor of chemosensitivity. We tested the levels of serum miR-21 in a cohort of 177 cases of advanced pancreatic cancer who received gemcitabine-based palliative chemotherapy. We found that a high level of miR-21 in the serum was significantly correlated with a shortened time-to-progression (TTP) and a lower overall survival (OS). The serum miR-21 level was an independent prognostic factor for both the TTP and the OS (HR 1.920; 95% CI, 1.274-2.903, p = 0.002 for TTP and HR 1.705; 95% CI, 1.147-2.535, p = 0.008 for OS). The results from a functional study showed that gemcitabine exposure down-regulated miR-21 expression and up-regulated FasL expression. The increased FasL expression following gemcitabine treatment induced cancer cell apoptosis, whereas the ectopic expression of miR-21 partially protected the cancer cells from gemcitabine-induced apoptosis. Additionally, we confirmed that FasL was a direct target of miR-21. Therefore, the serum level of miR-21 may serve as a predictor of chemosensitivity in advanced pancreatic cancer. Additionally, we identified a new mechanism of chemoresistance mediated by the effects of miR-21 on the FasL/Fas pathway. © 2012 Federation of European Biochemical Societies.
Chromatin and the DNA damage response: The cancer connectionMartijn S. Luijsterburg | Haico Van Attikum
Volume 5, Issue 4, August 2011, Pages 349-367
The integrity of the human genome is constantly threatened by genotoxic agents that cause DNA damage. Inefficient or inaccurate repair of DNA lesions triggers genome instability and can lead to cancer development or even cell death. Cells counteract the adverse effects of DNA lesions by activating the DNA damage response (DDR), which entails a coordinated series of events that regulates cell cycle progression and repair of DNA lesions. Efficient DNA repair in living cells is complicated by the packaging of genomic DNA into a condensed, often inaccessible structure called chromatin. Cells utilize post-translational histone modifications and ATP-dependent chromatin remodeling to modulate chromatin structure and increase the accessibility of the repair machinery to lesions embedded in chromatin. Here we review and discuss our current knowledge and recent advances on DNA damage-induced chromatin changes and their implications for the mammalian DNA damage response, genome stability and carcinogenesis. Exploiting our improving understanding of how modulators of chromatin structure orchestrate the DDR may provide new avenues to improve cancer management. © 2011 Federation of European Biochemical Societies.
Non-coding RNAs in cancer initiation and progression and as novel biomarkersS. Patrick Nana-Sinkam | Carlo M. Croce
Volume 5, Issue 6, December 2011, Pages 483-491
Cancer represents a complex group of heterogeneous diseases. While many cancers share fundamental biological processes (hallmarks of cancer) necessary for their development and progression, cancers also distinguish themselves by their dependence on distinct oncogenic pathways. Over the last decade, targeted therapies have been introduced to the clinic with variable success. In truth, single targeted therapies may be successful in only a subset of malignancies but insufficient to address malignancies that often rely on multiple pathways, thus evading single targeted agents. Investigators have recently identified potentially functional components of the human genome that were previously thought to have no biological function. This discovery has added to the already established complexity of gene regulation in the pathogenesis of cancer. Non-coding RNAs represent key regulators of gene expression. Improved knowledge of their biogenesis and function may in turn lead to a better understanding of the heterogeneity of malignancies and eventually be leveraged as diagnostic, prognostic and therapeutic targets. MicroRNAs (miRNAs or miRs) for example, have the capacity for the regulation of multiple genes and thus redirection or reprogramming of biological pathways. However, several other members of the non-coding RNA family may be of equal biological relevance. In this review, we provide a perspective on emerging concepts in the clinical application of miRNA and other non-coding RNAs as biomarkers in cancer with an eye on the eventual integration of both miRNA and other non-coding RNA biology into our understanding of cancer pathogenesis and treatment. © 2011.
Transcriptional modulation induced by ionizing radiation: P53 remains a central playerSharon Rashi-Elkeles | Ran Elkon | Seagull Shavit | Yaniv Lerenthal | Chaim Linhart | Ana Kupershtein | Ninette Amariglio | Gideon Rechavi | Ron Shamir | Yosef Shiloh
Volume 5, Issue 4, August 2011, Pages 336-348
The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed together six datasets that probed transcriptional responses to ionizing radiation (IR) - our novel experimental data and 5 published datasets - to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles we recorded from 5 cancerous and non-cancerous human cell lines after exposure to 5 Gy of IR, most of the responses were cell line-specific. Computational analysis identified significant enrichment for p53 target genes and cell cycle-related pathways among groups of up-regulated and down-regulated genes, respectively. Computational promoter analysis of the six datasets disclosed that a statistically significant number of the induced genes contained p53 binding site signatures. p53-mediated regulation had previously been documented for subsets of these gene groups, making our lists a source of novel potential p53 targets. Real-time qPCR and chromatin immunoprecipitation (ChIP) assays validated the IR-induced p53-dependent induction and p53 binding to the respective promoters of 11 selected genes. Our results demonstrate the power of a combined computational and experimental approach to identify new transcriptional targets in the DNA damage response network. © 2011 Federation of European Biochemical Societies.
Evolving concepts in melanoma classification and their relevance to multidisciplinary melanoma patient careRichard A. Scolyer | Georgina V. Long | John F. Thompson
Volume 5, Issue 2, April 2011, Pages 124-136
In the initial period after melanoma was recognised as a disease entity in the early 1800's, it was subclassified on the basis of its presumed origin (from a precursor naevus, from a melanocytic precursor lesion acquired during adult life or in previously blemish-fee skin). In 1967 the eminent American pathologist, Dr Wallace Clark, proposed a histogenetic classification for melanoma in which the disease was subdivided predominantly on the basis of histopathological features of the intra-epidermal component of the tumour adjacent to any dermal invasive component. The subtypes were superficial spreading melanoma (SSM), lentigo maligna melanoma (LMM) and nodular melanoma (NM). Whilst additional entities, including acral lentiginous melanoma, mucosal melanoma, desmoplastic melanoma and naevoid melanoma have since been recognised, SSM, LMM and NM remain in the latest (2006) version of the WHO melanoma classification. Clark's histogenetic classification has been criticised because the criteria upon which it is based include clinical features (such as the site of the melanoma) and non-tumourous histopathological features (such as the character of the associated epidermis and the degree of solar elastosis) and also because of overlap in defining features, lack of an independent association with patient outcome and minimal relevance as a determinant of clinical management. However, such criticisms fail to acknowledge its importance in highlighting the myriad of clinical and histological guises of melanoma, which if not recognized by clinicians and pathologists will inevitably lead to a delay in diagnosis and a concomitant adverse clinical outcome. Recently, mutually exclusive oncogenic mutations in melanomas involving NRAS (15-20%), BRAF (50%), CKIT (2%), and GNAQ/GNA11 (50% of uveal melanomas) have been identified. This might herald the beginning of a new molecular classification of melanoma in which the biologically distinct subsets share a common oncogenic mechanism, behave clinically in a similar fashion and require similar clinical management. These discoveries are already being successfully exploited as therapeutic targets in clinical trials of metastatic melanoma patients with promising activity. Whilst there remains much to be discovered in this rapidly evolving field, there is already great optimism that more rational and effective therapies for melanoma patients will soon be widely available. Crown © 2011.


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Vocaloid Kagamine Rin - Knife by yuegeneWatch
©2012-2016 yuegene
This is adorable!
loving it <3 her features really make the cosplay something really good
those eyes
i spazzed <3
Not to say that it's a bad thing... But you look so different when you don't use that stark black accent around your eyes you usually do. I seriously looked at the updates from my deviations and was like "...what?"
But you're awfully cute like this. ^ ^
But you're awfully cute like this. ^ ^
Please read the Artist's comment before comment.
This Girl cosplay as Kagamine Rin from Vocaloid and her name is Ray.
This Girl cosplay as Kagamine Rin from Vocaloid and her name is Ray.
I guess the confusion stems from the fact that her face almost looks similar to yours, Yuegene. It wasn't until I read the description that I realize that wasn't you cosplaying as Rin.
Does Ray have a DA page or cosplay page~?OwO~
Does Ray have a DA page or cosplay page~?OwO~
kawaii....nice cos-picture....
how do ou make ur cosplay look soooooo good~?
OMYGOODIES!!!! so cute!!! CUTE!CUTE!CUTE!!>3<
LOVE those Expression.. Gyaaaaa... so Gorgeous.. XD
so kawaii!!
one pupil's bigger than the other but still gorgeous
I think that might be just the light, and helped a little by the strand of hair over her right eye, so the pupil just looks smaller than her left
just perfect!


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- Report: #1110798
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Complaint Review: senior sidekicks of central florida llc
senior sidekicks of central florida llc666 sanford, Florida USA
senior sidekicks of central florida llc Shelby Nicole Medley rip off, run by crooks, owned by criminals sanford Florida
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Shelby nicole medley is a fraud. She is a criminal. She is a theif. She is a parasite. Look on line, google her name before doing business with her or anyone associTed with her.
This report was posted on Ripoff Report on 12/27/2013 05:45 AM and is a permanent record located here: http://www.ripoffreport.com/r/senior-sidekicks-of-central-florida-llc/sanford-Florida-66666/senior-sidekicks-of-central-florida-llc-Shelby-Nicole-Medley-rip-off-run-by-crooks-owne-1110798. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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On Tap Today: Winter music is a blast
What sounds of winter await us--besides the rattling of icy blasts shaking the storm windows, that is.
Happily, the sounds of the winter season are warmer than that, and they come courtesy of everyone from Green Day to Wiz Khalifa. Check out our roundup of tunes here. »Read Full Blog Post
Bright lights outshine Trans-Siberian Orchestra in ho-hum show
Taking on Christmas staples with a blend of symphonic bombast and progressive rock drama, Trans-Siberian Orchestra brought a much needed edge to the pleasant, ho-hum holiday music landscape beginning in 1996 , and in the process TSO has become one of the highest-grossing touring acts in North America.
But right before the start of the first of two TSO shows at the BMO Harris Bradley Center on Sunday, there was a curious sound, or really a lack of a sound. Following some meek applause when the lights went dark, the crowd strangely grew quiet, to the point that the only noise was the awkward, quiet hiss of fog machines. »Read Full Article(14)


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Grand Theft Auto IV and its highly successful sequel Grand Theft Auto V are now available for a reduced price on Xbox Live. Also included in the sale are the two excellent DLCs released for Grand Theft Auto IV – The Ballad Of Gay Tony and The Lost and Damned.
The sale is only available for Xbox Live Gold subscribers at the moment. There's no word if it will ever be available for everyone or when the deals will expire. Here are all the discounted items:
- GTA 4: The Ballad of Gay Tony – £5.39/$7.99
- GTA 4: The Lost and Damned – £3.37/$4.99
Yesterday we have reported that Grand Theft Auto V is the most successful game of 2013, shipping around 32.5 million units since its September launch. A truly impressive feat and completely deserved, considering how good the game is.
Grand Theft Auto V is now available on PlayStation 3 and Xbox 360. Despite the lack of official announcements, it looks like the game is eventually going to be released on PC as well as on PlayStation 4 and Xbox One. The game is also going to receive its first story DLC later this year, which should be set in North Yankton according to some rumors circulating in the past few months.


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- Report: #1010435
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Complaint Review: wholesale escapes
wholesale escapesmarket street Charleston, South Carolina United States of America
wholesale escapes then they send you to "passport to travel" free airplane tickets not exactly free charleston South Carolina
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This report was posted on Ripoff Report on 02/07/2013 12:33 PM and is a permanent record located here: http://www.ripoffreport.com/r/wholesale-escapes/Charleston-South-Carolina-29401/wholesale-escapes-then-they-send-you-to-passport-to-travel-free-airplane-tickets-not-exa-1010435. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Advertisers above have met our
strict standards for business conduct.


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POINTE-AUX-CHENES: Cook meals for grieving families
Published: Wednesday, February 9, 2011 at 10:28 a.m.
Last Modified: Wednesday, February 9, 2011 at 10:28 a.m.
The Ultreya, or prayer-meeting group, is scheduled to meet today at St. Charles Borromeo Catholic Church, 1227 La. 665, Pointe-aux-Chenes. The group is scheduled to meet Feb. 16 at St. Charles Gregory Barbarigo Catholic Church, 1005 Williams Ave., Houma.
St. Charles Borromeo Catholic Church, 1227 La. 665, Pointe-aux-Chenes, is in need of a director of religious education for its CCD program. For information, call 594-6801.
The Kay Cee Auxiliary is preparing meals for the family of deceased parishioners on the day of the funeral. The meal is meant to feed about 30 people and usually consists of chicken gumbo, potato salad, cake, French bread and soft drinks. If you want to assist in cooking the meal, call the rectory office at 594-6801 or Donna Dupre at 594-4474.
Tableau and dance: The Krewe de Bonne Terre's annual tableau and dance is scheduled for 5:30 p.m. Feb. 19 at the Montegut Recreation Center, 107 Recreation Drive. The tableau is scheduled for 6:30 p.m., with the dance set for 9 p.m. Junior Lacrosse and Sumtin Sneaky are set to perform. Admission to the tableau is $5. Admission to the dance is $15. The event is BYOL and ice chests with no plugs are allowed. For information, call Drake Dupre at 790-1725, Bryan LeBoeuf at 688-6180 or Alcee Dupre Jr. at 594-5888.
Knights news: The Knights of Columbus Council No. 8616 is sponsoring a Catholic youth-leadership award for graduating seniors. All high-school seniors from Isle de Jean Charles, Montegut and Pointe-aux-Chenes can apply. For information or nomination forms, call Dennis Ledet at 594-7464.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Now there is a guy with make over experience.
Maybe he could ignite some new life into Pepboys.
He is said to be available now.
so he can alienate customers and spend billions of $$$ to renovate stores with high priced merchandise with no real security that it will bring back all those customers??? Look at JCP. "Innovators" like Johnson needs to stay with companies like Apple where his views make sense not at retailers like PBY and JCP.
If ron Johnson is hired its guaranteed those kayaks will be out front again,


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Hempfield Manor in Greensburg, PA
Discover More:
Hempfield Manor is a medium-sized nursing home facility in GREENSBURG, Pennsylvania ( Westmoreland county ). They have 120 beds and 112 residents. Hempfield Manor participates in Medicare and Medicaid and are classified as a For profit - Corporation ownership. They offer residential councils. They are not located inside of a hospital. They do not belong to a continuing care community. Additional information about Hempfield Manor can be viewed by clicking one of the links above for directions and maps, inspection / survey results, and resident reviews.
Resident Ratings | Basic Information | Staff Size | Medicare Ratings | Ratings Comparison
|Resident and Family Ratings
How would you rate your overall experience withClick to learn more: Inspection Results - Penalty Enforcements - Maps and Directions
|Basic Information and Map Location
Quality of care and other service information can be reviewed below.
|Staff Size
Hempfield Manor provides an average of 0.83 registered nurse hours, 0.89 Licensed practical nurse / LVN hours, and 2.33 CNA hours per day per resident.
|Additional Care Home Services
Medicare and Medicaid participation for Hempfield Manor began on Oct 04, 1985.
The average length of stay at Hempfield Manor is approximately 111 days. (this may include both short and long-term care (LTC) visits).
|Medicare and Medicaid Ratings
Overall Rating: 3 stars
Health Inspection Rating: 3 stars
Staff Rating: 3 stars
Quality Measures Rating: 4 stars
Registered Nurses Rating: 4 stars
|Ratings Comparison
Hempfield Manor in GREENSBURG, Pennsylvania has 120 beds compared to a Pennsylvania average of 125.83 and a National average of 106.41. As of the last update they had 112 residents compared to a PA average of 113.82 and a National average of 88.66. This results in a 93.33% occupancy rate compared to a Pennsylvania average of 90.46% and a national average of 81.98%.
HEMPFIELD MANOR's star ratings compare as follows:
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