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Symphony Hall opened in 1991 to immediate public and critical acclaim. With its world class acoustics and stunning auditorium it is considered to be not only the UK's finest concert hall but also one of the best in the world.
Symphony Hall presents prestigious international orchestras and is also home to the City of Birmingham Symphony Orchestra. Complementing the classical programme is the best in jazz, world music, folk, rock, pop and stand-up comedy.
The Hall also plays an important role in the life of the region and is regularly used for community events, graduation ceremonies and conferences. In all over 370,000 people attend around 320 events at Symphony Hall every year.
Seating capacity: 2262
Image © Symphony Hall Birmingham
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August 2016
September 2016
October 2016
Symphonie Fantastique:
Nicholas Collon, Vilde Frang, City Of Birmingham Symphony Orchestra (CBSO)
The Spirit Of England:
City of Birmingham Symphony Chorus, City Of Birmingham Symphony Orchestra (CBSO), Susan Gritton
November 2016
VIP Deal
Lady Sings The Blues:
Rebecca Ferguson, Chelsea Alice Scott, Max Restaino
From: £33.95
Simply Gershwin:
London Concert Orchestra, Gweneth-Ann Jeffers, Njabulo Madlala
Viv McLean
From: £28.50
December 2016
Jools Holland & His Rhythm And Blues Orchestra, Pauline Black, Arthur 'Gaps' Hendrickson
From: £40.70
Jools Holland & His Rhythm And Blues Orchestra, Pauline Black, Arthur 'Gaps' Hendrickson
From: £40.70
Christmas Classics:
City Of Birmingham Choir, London Concert Orchestra
From: £37.00
Christmas Carol Singalong:
Louise Dearman, London Concert Chorus, London Concert Orchestra
From: £32.00
White Christmas:
Laura Tebbutt, Tom Howar, John Rigby
Capital Voices, London Concert Orchestra
From: £35.50
Carols By Candlelight:
Canzonetta, Mozart Festival Orchestra, Keri Fuge
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Last Night Of The Christmas Proms:
Madeleine Pierard, Nicky Spence, Jonathan Antoine
Hilary Davan Wetton, London Concert Orchestra
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Abba Classics:
London Concert Orchestra, Annie Skates, Emma Kershaw
Dean Collison, David Combes, Capital Voices
From: £39.50
Handel By Candlelight:
Crispian Steele-Perkins, Daisy Brown, Steven Devine
Canzonetta, Mozart Festival Orchestra
From: £32.00
The Sound Of Musicals:
Manchester Concert Orchestra, Richard Balcombe
From: £35.50
January 2017
February 2017
March 2017
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An Evening of Yes Music & More:
Anderson Rabin & Wakeman
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April 2017
20th Anniversary:
Lord Of The Dance - Dangerous Games
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June 2017
July 2017
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Venue Facts
Venue: Symphony Hall
Broad Street
West Midlands
Website: thsh.co.uk
Enquiries: 0121 345 0600
Bookings: 0121 345 0602
Disabled Bookings: 0121 780 4949
Seating Plan: View the Seating Plan
→ New Street 9 min walk
→ Snow Hill 10 min walk
→ Corporation Street 10 min walk
→ Snow Hill 10 min walk
→ New Street 10 min walk
→ Five Ways 12 min walk
News and Announcements RSS feed
- Thursday 25th Aug: Chris De Burgh to play Symphony Hall, Birmingham in April 2017
- Tuesday 23rd Aug: Brendan Cole to appear at Symphony Hall, Birmingham in March 2017
Have Your Say
- Read the full review and 1 more
First time visited (Fri 1st May 2009). Saw Madeline Peyroux - see review. Excellent venue, highly recommended, fantastic sound, very comfortable chairs. We originally sat in front row (as had done at Warwick Arts to see this act) but this time too far over to right, in front of huge… (cont'd) Phil A from Northampton
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The Logitech Wireless Desktop MK320-USB-AP is an amazing combo of keyboard and mouse. With a considerably long range of 2.4 GHz, the keyboard is the ultimate wireless solution to typing. The full sized keyboard also has multimedia keys incorporated within it to provide easy and direct access to your favourite songs and videos. It also has internet keys to allow you to instantly jump on to the internet. Besides, the mouse is offered with a snap-on receiver. Having a long battery life that could facilitate you to work for hours without charging, the set is perfectly compatible with Windows XP, Windows Vista and Windows 7 operating systems.
Have you purchased this item?Write A Review
The best wireless keyboard. Its affordable, durable, useful. It has special multimedia keys and most importantly had On/Off switch on both keyboard and mouse which saves a lot of battery power when not in use. Have noticed that when not using the mouse or keyboard after a while it goes to sleep mode which is another plus point of this product. Have no issues in setting it up, just lug and play and Yes it can be used in boot mode as well (wasn't sure before) Only one improvement needed, it should have LED indicators for power, CAPS, NUM and Scroll lock on keyboard.
Its for my Laptop use.
Plug and play device. Works great with less battery consumption.
keayboard is working great but battery in mouse is not lasting , need to change in every 2 weeeks.
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Campbell County breaks in their new football stadium with a 27-7 win over Newport.
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Play any type of Game at Y8.com. The biggest Game Collection to play free online. Flash, Unity 3D, Html5, Android, Java and Shockwave.
Get the marble to the hole within the time limit and in the fewest shots possible in this zen mini-golf-style game. Collect as many gems as possible to earn points. Bonus points can be won by saving shots and completing levels quickly. Plan ahead by clicking and dragging on the screen to move the camera and get a better idea of obstacles in the path. Some platforms are tricky while others are missing their sides - or even moving! Be careful, and keep an eye on the wind. Can you get a hole in one? Play now and give it your best shot!


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News / Media
Three years ago a gentlemen attended one of our planning meetings to see how he could help a community car show. Now three years later this gentleman, G. Michael Dorvillier, has helped catapult the La Jolla Concours d'Elegance into one of the largest concours in Southern California. His passion and continual drive has been key to turning this from a community car show to the La Jolla d'Elegance and a celebration of three days of incredible motoring events. Under the tutelage of our Chairman, last year the La Jolla Concours d'Elegance was named one of the top three events to attend in the world by Octane Magazine.
Michael Dorvillier is a major force behind the La Jolla Concours d'Elegance and has a passion for these beautiful masterpieces. He grew up in San Juan, Puerto Rico and spent his earlier adulthood in New England but opportunity brought him to America's Finest City.
Michael has spent many years building a very successful career as a Registered Principal and Financial Advisor with LPL
Financial and is also the founding partner of Symbio Financial Partners.
As a passionate antique car collector, Michael Dorvillier has made a five-year commitment to chair and oversee the expansion of the La Jolla Concours d'Elegance, which supports the La Jolla Historical Society and the Monarch School for Homeless Children. With his leadership, once again the La Jolla Concours d'Elegance will showcase some remarkable antique cars at the Ellen Browning Scripps Park at the La Jolla Cove with events all weekend.
Q&A with G. Michael Dorvillier
To whom/what do you attribute your passion for classic cars?
As a child I was always attracted to old cars and in high school I would buy old cars and fix them up as it was all I could afford. I have always had a passion and a respect for old cars. My first car was a Ford Pinto Station Wagon and you could see the ground through the floor boards. In high school my brother was restoring a Dodge and I was really impressed by his abilities and thought it would be cool to do some day. That is when I got my first real car that I was able to fix up which was a Triumph Spit Fire . I was never as good as my brother, Andy, so in college I started purchasing exotic cars oversees and would ship them over, have people fix them up and sell them for a nice profit and drive cool cars.
You have committed to Chairing the La Jolla Concours d'Elegance for a total of 5 years. What goals do you have for your tenure?
My goal is to have an event that is world class and to make this an event that would showcase La Jolla to the world. We have such a spectacular village here and I would love to show off this town to the best of the best in the car world.
How would you like to envsion the LJCDE in another decade on the 20th Anniversary?
I would like to see the event become a week-long event that is sold out at end of the prior year's show, bringing the best of the best from automobiles, sponsors and vendors into the village.
What is the most memorable automobile you have seen at the show and what made it special?
A 1955 Oldsmobile Star Fire Convertible is my dream car. My favorite car from the show was from the Petersen Museum. It is special because of its grace and artistic shape; that was an incredible feat at that time.
What is your favorite day of the weekend events?
It is the day of the Concours. The entire team works so hard for 365 days of the year and it is just for that 365th day. It is always such a sense of satisfaction to see it come together.
If you were not the Chairman, what committee would you sit on?
I would be on the entertainment committee. That does not exist? I would create it then. I enjoy seeing all the pre-parties and day of events come together. It is very satisfying.
Please direct all media inquiries to:
McFarlane Promotions
Email: email@example.com
Phone: (619) 233-5008
La Jolla Concours BMW Tour d'Elegance Press Release
La Jolla Concours d'Elegance Press Release 2016
La Jolla Concours d'EleganceCalendar Notice 2016
La Jolla Concours d'Elegance VIP Party Release 2016
Click here to download Rolls-Royce Motor Cars Contemporary Classic Cocktail Party presented by Westime.
Photo Credit: Rudy Vaca
Photo Credit: Rudy Vaca
These images may be downloaded for editorial use with news pieces being published or broadcasted only. These images are not available for commercial, advertising or entertainment purposes without written consent of the La Jolla Concours d'Elegance.
Limited Press Passes Available – Please Click Here to Apply.
All applications must be received no later than Tuesday, April 1st at 5:00 PM.
June 2012
"From Car Show to Concours"
by Keith Martin, Publisher of Sports Car Market
Sports Car Market


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From very early in his career Liebermann frequently painted children, particularly orphans, either playing or working. His earliest works on the theme of childhood were painted at a time when Liebermann was influenced by Dutch painters of the 17th century, particularly Frans Hals. His first paintings of bathers were made in the mid-1870s. He remained deeply attached to Holland throughout his life, frequently visiting the coast around Scheveningen. This is the second of two oils, based on sketches Liebermann made on the Dutch coast in 1903. The figure in the middle appears rather stiffly posed, while the other boys are depicted more naturalistically.
August 2004


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- Report: #418796
Report - Rebuttal - Arbitrate
Complaint Review: Murray Fields, Managing Member Of Elite Premium Services
Murray Fields, Managing Member Of Elite Premium Services4045 S. Buffalo Dr., Ste A101-290 Las Vegas, Nevada U.S.A.
Murray Fields, Managing Member Of Elite Premium Services Warning! Murray Fields and Elite Premium Services did not pay for work do on home located in cental South Dakota. Las Vegas Nevada
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Anyone doing business with this person or company had better think twice as you shouldn't expect to be compensated for your work. I've never received an answer to any of my emails or phone calls.
Wells Fargo and Fannie Mae should be made aware of the way this person and company conduct themselves. I'm not to sure they shouldn't be referred to the proper authorities for investigation. They should not remain in business. All I can say, if you plan to do business with them "don't"!
Pierre, South Dakota
This report was posted on Ripoff Report on 02/01/2009 09:45 AM and is a permanent record located here: http://www.ripoffreport.com/r/Murray-Fields-Managing-Member-Of-Elite-Premium-Services/Las-Vegas-Nevada-89147/Murray-Fields-Managing-Member-Of-Elite-Premium-Services-Warning-Murray-Fields-and-Elite-418796. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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- Report: #289374
Report - Rebuttal - Arbitrate
Complaint Review: Garcia Media Group - Tvboxset
Garcia Media Group - TvboxsetTvboxset.com Internet Canada
Garcia Media Group - Tvboxset Worst decision I ever made was to order from this so called company! Internet
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The box set included 100 DVD's which were to say the least, the worst quality ever. 99% of them are unviewable and the ones that did come across were clearly taped off of TV and the picture was terrible.
I have tried to get a refund to no avail.
Platte City, Missouri
This report was posted on Ripoff Report on 12/06/2007 10:11 AM and is a permanent record located here: http://www.ripoffreport.com/r/Garcia-Media-Group-Tvboxset/internet/Garcia-Media-Group-Tvboxset-Worst-decision-I-ever-made-was-to-order-from-this-so-called-289374. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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About AppNexusAppNexus technology powers the most innovative trading solutions and marketplaces for Internet advertising. We power the ads that power the Internet. Founded in 2007, and growing rapidly since, we are consistently ranked as a top technology company in New York.
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CEO & Co-Founderfollow him on twitter
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Monthly Archives: January 2012
AppNexus: How We Manage Big Data
The agency Moxie Interactive published their 2012 trends report on "The Evolving Digital Ecosystem" in which they grant "big data" the number three spot in their annual trends list. NPR's Morning Edition also aired a two-part series on big data … Continue reading
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Nick Cannon and Son Moroccan Spend The Day in NYC
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Hingham Police Department
Drop-A-Dime Program
This form may be used by citizens to report drug or other illegal activity taking place in their neighborhood. When using this report you have a choice of indentifying yourself or remaining completely anonymous.
Please provide description of persons and vehicles, plate numbers, addresses/locations, the type of drugs and whether there are weapons available.
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Fall Color Tours 2016
Mackinac Island – Oct. 11
Traverse City Area – Oct. 8
Porcupine Mtns. – Oct. 14
Western U.P – Oct. 1
Crystal Mountain – Oct. 14
Grand Hotel – Somewhere in Time Weekend – October 28 – 30, 2016
Grand Hotel – Fall Michigan Golf Live – September 9 – 11, 2016
Fall Color in Northern Michigan and the Upper Peninsula!
Fall Color Tours! Maps & Guides!
Fall Color Update – October 26, 2015
We are now past peak in the Upper Peninsula. Although the last of the leaves are falling, it is still a good time to take a hike and enjoy the grandeur of the forests and mountain vistas of the Upper Peninsula. Snow will be falling soon, so get ready to enjoy the U.P. when it is covered in a blanket of white. Check out Ski Michigan for opportunities to ski in the U.P.
There is still peak color in some parts of Northern Lower Michigan with chances to catch a late fall color show in the Traverse City area – best color will be on the Old Mission Peninsula and along the coastal routes of the Leelanau Peninsula and the Sleeping Bear Dunes. You can also catch some late season peak color in the Petoskey and Harbor Springs area and catch the last of the color along the Tunnel of Trees, north of Harbor Springs. Also this week, Grand Hotel on Mackinac Island is having their first-ever Halloween Weekend at the Grand. Enjoy a weekend of Halloween activities and wear your spookiest, silliest, or craziest costume to the Halloween Ball and Costume Party on Saturday night. More info at: http://www.fallcolorblog.com/?p=1125
Here is our Fall Color Photo Tour – Mackinac Island – October 11, 2015
Get out and enjoy the very last big weekend of the fall color season!
Click through to the calendar for the latest events here.
Pure Michigan Fall Color Update – October 30, 2015
Here's a general guide to peak color weekends for 2015 in Northern Lower Michigan and the Upper Peninsula. (Based on historical observation. Subject to adjustments by Mother Nature.)
Upper Peninsula
September 26 – 27, 2015 – Early Color near the shores with some early Peak color coming along in the interior of the Upper Peninsula
October 3 – 4, 2015 – A Peak Color Weekend with some past peak areas in the Upper Peninsula
October 10 – 11, 2015 – A Peak Color Weekend, Many Regions near the shorline with Early Fall Color in the Upper Peninsula
October 17 – 18, 2015 – Mostly Past-Peak Color Weekend with some peak color near the shoreline in the Upper Peninsula
Northern Lower Michigan
September 26 – 27, 2015 – Early Color Weekend with some isolated areas of Peak Color
October 3 – 4, 2015 – Early Color Weekend with some isolated peak color in Northern Lower Michigan
October 10 – 11, 2015 – Early Color Weekend in Northern Lower Michigan
October 17 – 18, 2015 – Peak Color to Some Past Peak Color Weekend in Northern Lower Michigan
October 24 – 25, 2015 – Peak to Past Peak Color Weekend (look for the best of the remaining color near the lakeshore) in Northern Lower Michigan
Fall Calendar of Events – Highlights
Mackinac Island Fall Color Photos – October 3, 2012
Leelanau County Fall Color Photos – October 13, 2010
Traverse City Fall Color Photos – October 10, 2010


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Single Replacement Leather Tab to replace "broken away" halter tab. Each.
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Dover's Price:$3.99
The Lami-Cell Memory Pad is designed to help keep horse and rider comfortable. Made of gel foam with excellent "memory," this half pad helps keep the saddle in the right place while absorbing shock and helping to ease pressure points.
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The Lami-Cell Fleece-Lined Halter features an extra-wide nose and crown and cheeks that are covered in synthetic fleece to help protect against rubbing. This lined breakaway halter has an adjustable chin and two-buckle crown.
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Lami-Cell Reflective Halter is a great turnout halter. In attractive nylon with fleece padding at the crown and woven reflective strips throughout, it has a breakaway tab at the cheek.
Dover's Price:$34.99
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Arab Knowledge Report 2010/2011
Preparing Future Generations for the Knowledge Society
The Arab citizen lies at the heart of the process of building the desired knowledge society. The Arab Knowledge Report 2010/2011 proceeds to the stage of laying the foundations for the knowledge society by developing principles of dealing with the methodologies and mechanisms of preparing future generations to actively participate in building the knowledge society and access its vast domains. Dealing with this matter put us right in the midst of the processes of preparing and rehabilitating Arab citizens to enhance their skills; instilling values which control and direct their decisions and activities, and the methods and mechanisms of their empowerment. These maximize the opportunities of their active participation in building the knowledge society and reaping its benefits. these gains will be employed within the broader context and ultimate goal of achieving sustainable human development to support and retain the pride and dignity of the Arab people.
Download this Document
- Arab Knowledge Report Full Report 2010- 2011
- Table of contentes
- Arab Knowledge report Chapter 1
- Arab Knolwedge Report Chapter 2
- Arab Knowledge Chapter 3
- Arab Knowledge Report Chapter 4
- Arab Knowledge Report Chapter 5
- Arab Knowledge Report Chapte 6
- Arab Knolwedge Report 2009
- References and Background


text:
- Report: #364808
Report - Rebuttal - Arbitrate
Complaint Review: Courier Services A Scam (Global Express Services Ltd)
Courier Services A Scam (Global Express Services Ltd)Global Express Services Ltd Nationwide United Kingdom
Global Express Services Ltd Courier Services a scam Avon Valley Business Park Chapel Way, Bristol BS4 4EE United Kingdom
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Then after few days the courier services call me and tell that my parcel have a problem with the customs in malaysia. And they send me email:
-With reference to the delivery of your package, I wish to bring to your notice that your package has been placed on hold by the Malaysian customs for some reasons which happens to violate the shipping policies.
As the goods were brought on transit at Malaysian check point before further destination, the Malaysian custom detected that currency were included in your parcel. Thereby, certain commissions must be paid as customs duty via us which is for the immediate clearance of your package. For the main time all tracking information has been with held , this is in accordance to the mode of operations in the Courier sector for financial delivery. We have already taken order number for this package from the custom.
You are required to follow all instructions giving to you to facilitate the release of your package. Please, be informed that you are to pay the required charges listed below for the immediate release of your package. As soon as we receive confirmation and evidence of payment of the charges below then we would dispatch your package immediately. The date and time of departure and expected date of delivery will be sent to you.
Please do not hesitate to call or email, should you need any further information. I look forward to hearing from you.-
Administrative.............. RM499.99
Clearance................... RM2,950.99
TOTAL....................... Rm3,450.98
I make a police report, the police in sabah try to find the office but they couldn't find it, the address:
Global Express Services Ltd
Block E, Ground Floor,
Damai Point Commercial Centre,
Kota Kinabalu, Sabah, Malaysia
Email: email@example.com
And they will ask you to bankin the payment to this account number:
Name: Julianah Binti Jaleel
Alliance Bank, Account No. 640960020020577
Here i would like to tell all the girls out there beware to all of this if you know someone on internet please don't trust them completely. And i already heard that's a lots of complaining about this courier services. If you the victim please make a police report as soon.
So, clearly this is a rip-off or a scam.
The details of this company is as follows:
Global Express Services Ltd
Unit 8
Avon Valley Business Park
Chapel Way, Bristol BS4 4EE
Email: firstname.lastname@example.com
Tel: +447024067693, +448715033669
Operations Manager: Robert Cade
Email: email@example.com
Tel: +447024013687
Bookings & Sales Dept
Accounts & Credit Control Dept
Global Express Services Ltd
Block E, Ground Floor,
Damai Point Commercial Centre,
Kota Kinabalu, Sabah, Malaysia
Email: email@example.com
Contact person: James Ruben
Telephone : +60133260247
Michael Coleman
Telephone : +60133260245
Benson White
Telephone: +60132693782
Kuala Lumpur
This report was posted on Ripoff Report on 08/19/2008 11:45 PM and is a permanent record located here: http://www.ripoffreport.com/r/Courier-Services-A-Scam-Global-Express-Services-Ltd/nationwide/Global-Express-Services-Ltd-Courier-Services-a-scam-Avon-Valley-Business-Park-Chapel-Way-364808. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
Ripoff Report has an exclusive license to this report. It may not be copied without the written permission of Ripoff Report.
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SAN DIEGO - Gilbert Melendez is becoming an increasingly bigger fish in an increasingly smaller pound.
The Strikeforce lightweight champion and top-10 pound-for-pound fighter earned a shutout unan read news >>
SAN DIEGO - Strikeforce lightweight champion Gilbert Melendez admits he may bringing some of it upon himself.
After all, if you're going to claim to be the best in the world, you'd better be read read news >>
SAN DIEGO - Strikeforce female featherweight champion Cristiane "Cyborg"
Santos might not be completely out of potential
opponents at 145 pounds, but the line of volunteers doesn't exactly
reach a read news >>
A lightweight bout between former KOTC champ Bobby Green and veteran competitor Alonzo Martinez has been added to next month's "Strikeforce: Rockhold vs. Jardine" event.
Strikeforce officials re read news >>
Jorge Masvidal entered his recent Strikeforce title fight with an injured right hand, and he quickly made it worse in the first round of an eventual five-round decision defeat to champ Gilbert Melend read news >>
MMAjunkie.com Radio today welcomes to the studio Luke Rockhold, who puts his newly won middleweight title on the line against Keith Jardine at Saturday's Strikeforce event.
Additionally, after a r read news >>
It's been a bit of a seesaw for American Kickboxing Academy.
This past September, the team went 4-0 at "Strikeforce Grand Prix: Barnett vs. Kharitonov," and middleweight Luke Rockhold unseated th read news >>
With just four professional fights under her belt, it appears Ronda Rousey will compete for Strikeforce gold.
MMAjunkie.com has confirmed with multiple sources
that Rousey and Strikeforce 135-pou read news >>
LAS VEGAS - Fans have pooh-poohed the matchup, and much of the media has written it off as meaningless.
Additionally, Strikeforce middleweight champion Luke Rockhold hasn't made it a secret that u read news >>
Sarah Kaufman's frustration is unmistakable.
By all indications, the former women's champ won't get a chance to win
back the bantamweight belt any time soon. Strikeforce CEO Scott Coker
today to read news >>
The California State Athletic Commission has suspended and fined Strikeforce women's featherweight champion Cristiane "Cyborg" Santos due to a failed drug test.
CSAC officials today announced the read news >>
Watch Strikeforce middleweight champ Luke Rockhold and challenger Keith Jardine hit their marks ahead of their Saturday showdown in Las Vegas. read news >>
Strikeforce women's featherweight champion Cristiane "Cyborg" Santos has apologized for a failed drug test, but she's blaming a dietary supplement for it.
As MMAjunkie.com reported on Friday, Sant read news >>
LAS VEGAS - Luke Rockhold's first title defense proved a rather quick and efficient one.
The Strikeforce middleweight champion used a late-first-round onslaught to batter UFC vet Keith Jardine - a read news >>
LAS VEGAS - Soon, the Strikeforce heavyweight grand prix will come to a conclusion, and the entire division then will be sent to the UFC.
But first, the tournament champion - either Josh Barnett o read news >>


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Kurdistan Region-Iraq News in brief
Kurdistan Region-Iraq News in brief
10, 2012 - Sulaimaniyah,
Erbil-Hewler, Duhok, Kirkuk, Kurdistan Region 'Iraq'
90% of water shortage
solved in Erbil, says Water Directorate
Erbil: Erbil's Water Directorate said 90 percent of
water shortage problems have been solved in Erbil
and many of the city's neighborhoods had water
problems in the past few months. Directorate
spokesman Massoud Mohammed said: "Erbil city had
water problems from the middle of May until the
beginning of June but now 90 percent of the shortage
has been fixed. "Only 10 percent of the city has
water issues, such as Sarkarezan, Galwezh and
Sebardan neighborhoods due to drought. It is
expected that the directorate will sort this problem
in the next few days." Mohammed added that the
directorate is now working on two water projects -
surface-water project 3 and 4. The neighborhoods
suffering from a lack of water are 159 Gulan,
Khanzad, Sarwaran 2, Raparin 2, Kuwestan and Nawroz
due to power cuts. aknews.com
New US General Consul to
Kurdistan Region begins work,
Erbil: Paul Steven began his work on Monday in Erbil
as the new US General Consul to the Kurdistan
Region.In a meeting with the head of foreign
relations of the Kurdistan Regional Government Falah
Mustafa, Steven explained his country's program to
strengthen work between the two countries, said a
statement from the Kurdistan Regional Government.
Mustafa praised the former US Consul to Erbil Alex
Laskaris and his role in making the US-Kurdistan
relationship stronger. Both sides talked about ways
of enhancing sectors in the region, such as economy,
trade, education and culture. aknews.com
Barzani receives Obama's
letter on mutual understanding
Erbil: Kurdish region president Massoud Barzani
received Monday a letter from US president Barrack
Obama stressing bilateral understanding, according
to an official statement here. The statement, copy
received by Aswat al-Iraq, added that the new US
General Consul Powell Stephen handed over the
letter. Stephen confirmed that he will try to
establish an important American presence in the
region, according to the statement. aswataliraq.info
International Peace
Organization to meet in Kurdistan
Erbil: Kurdish region president Masoud Barzani met
International Peace Organization delegation,
according to an official statement. Head of the
Organization Yan Jim Kin disclosed that the coming
conference will be held in Kurdistan. He expressed
appreciation to brotherly relations among the
region's ethnic components and the stability of the
situation there. On the other hand, President
Barzani expressed support to the work of the
organization in the Kurdish region. aswataliraq.info
Kurdistan produces 3,000 MW of power
Erbil: The Kurdistan region is producing 3,000 MW of
power, according to electricity minister, who
underlined that the ministry plans to raise them to
6,000 by 2015. "Our production capacity now is 3,000
and we provide citizens with 22 hours," Yassin
Abubakr Mawti said. "Works ongoing to produce 6,000
MW by 2015 through the establishment of three dams
to get electricity through the hydraulic mechanism
and to benefit from them in projects related to
agriculture and tourism," he added. aswataliraq.info
Copyright ©, respective author or news agency
Kurd Net
does not take credit for and is not responsible for the content of news
information on this page
Copyright © 1998-2016
Kurd Net®
. All rights reserved Ekurd.net
All documents and images on
this website are copyrighted and may not be used without the
permission of the copyright holder.


text:
<b>YOUR HEALTH | </b>By Katie Murdoch Herald writer
For some, sensitivity to scents isn't something to turn up one's nose at — it could signal an underlying health problem.
Feeling physically ill after taking a whiff of perfume could signal an allergy, asthma or another medical problem that warrants seeing a physician.
However, be wary of confusing reaction to the aroma of cleaning products or colognes with an allergy.
Scents and fumes are considered irritants and shouldn't be confused with allergens, advised Dr. David Naimi of the Northwest Asthma and Allergy Center.
"No one is truly allergic to fumes or scents," Naimi said.
That said, scents and fumes can have a significant effect on a person's quality of life. This could include causing such symptoms as cough, nasal congestion and watery eyes and nose. If these symptoms occur, it would warrant getting checked out by a doctor to rule out asthma or a vocal cord dysfunction, for example, as those conditions can be exacerbated by scents and perfume, Naimi said. A simpler remedy would be using nonhabit-forming nasal sprays.
"Even what would be thought of as a 'mild runny nose' on a daily basis can actually have an important impact on vital parts of our lives such as sleep, energy level, work productivity and school performance," he wrote in an email.
One remedy for scent sensitivity is common sense.
If aromas irritate you, don't light incense or scented candles and get up and move away from someone with an offensive perfume, advises allergist Dr. Marlene Peng of Seattle's Minor and James Medical facility, a health partner of Swedish/Edmonds.
Unlike a disorder or disease, scent sensitivity is more of an irritant response and doesn't require a test before diagnosis or treatment.
"It's purely odor sensitivity," she said.
Some patients have felt they needed to wear a mask to avoid irritation, but Peng said the degree really depends on how far the person wants to take it.
"Strong odors can bother anyone," she said. "Some say they can smell an odor someone wore five days ago. That could be true but it's not the norm."
However, someone with an underlying issue such as asthma is more reactive to obnoxious odors like bleach or car exhaust. And scented soap or lotion could aggravate skin of those with eczema.
When a person's asthma is under control, they'll be less irritated by scents. With eczema, a patch test rules out allergies: Fragrances or chemicals are applied to stickers and stick to the skin. There could be a problem if there is a rash after the patch is pulled off.
Peng tells patients with sensitive or hyperactive noses that the main thing is to avoid those with an irritating aroma.
"The only thing you can do is move or ask them not to wear it," she said.
For some patients, treatment is an option to remedy an underlying health problem.
When symptoms involve cough, shortness of breath and chest tightness a physician could rule out asthma or bronchial hyper responsiveness as an underlying cause and prescribe appropriate treatment.
Pre-existing allergies mean sensitivity to scents could be worse.
"If their respiratory tract is already inflamed, it is possible that they will subsequently also be even more sensitive to scents, fumes, or irritants in the environment," Naimi wrote.


text:
Opened 7 years ago
Closed 7 years ago
Last modified 5 years ago
#12499 closed (wontfix)
Allow a model's Meta to specify a single multi-db alias
|Reported by:
|crucialfelix <crucialfelix@…>
|Owned by:
|Database layer (models, ORM)
|Triage Stage:
|Has patch:
|Needs documentation:
|Needs tests:
|Patch needs improvement:
|Easy pickings:
Some, perhaps most models are clearly intended to work only with one connection or another in a multi-db project.
Currently you can specify:
objects = ModelManager().db_manager('legacy')
but I think the manager by default could look for:
class Meta:
connection = 'legacy'
and automatically bind to that connection
also I've run into a problem when running tests. the test runner causes each connection to create a test db which then creates all models on all connections.
if a connection does not support gis, or the model is not intended to be run on that connection ever, then the test db shouldn't create that table. thus I think that a model should be able to specify a single connection alias.
the above Meta setting would allow create_test_db to only create tables as needed for that connection.
Change History (2)
comment:1 Changed 7 years ago by russellm
- Needs documentation unset
- Needs tests unset
- Patch needs improvement unset
- Resolution set to wontfix
- Status changed from new to closed
This feature was implemented in an early draft of multi-db, and specifically removed. The database shouldn't be specified as a Meta property - consider the case of reusable apps. If your model defines Meta.connection (the original draft called it Meta.using), you can't share that model with any other Django user without forcing your particular database usage strategy.
comment:2 Changed 5 years ago by jacob
- milestone 1.2 deleted
Milestone 1.2 deleted


text:
Dance, Wrist Locks & Sub-Teens
View Single Post
Dojo: Tsubaki Kannagara Jinja Aikidojo; Himeji Shodokan Dojo
Location: Renton
Join Date: Feb 2005
Posts: 2,207
Re: Dance, Wrist Locks & Sub-Teens
Thomas Donelson
The purpose of the wrist-lock, like a Gooseneck, say with two thumbs on the back of the hand of the opponent, and fingers around the palm of the hand of the attacker, is so that I can control my position in relation to the potential paths for the attacker's feet and free arm. Further to give the attacker some area of free movement, so he an express his anger in some movement, yet while I protect myself.
The Dance is really footwork positioning, and discharge of Anger. Problem solving phrases can also be used during the time of the dance. The Attacker is sometimes willing to lessen the intensity of his attack, when both my hands are holding one of his hands, and my feet are positioned away, so the I am not in a polsition to kick or attack the attacker. By taking purely defensive actions, I show respect for the Anger of the attacker, and give him a chance to discuss problem resolution.
There is a sense of loyalty to to the teachings and focus of varous schools of Aikido and Martial Arts. Each branch of Martial Arts has reasons for its focus on some martial art forms, other than wrist-lock dance steps. My suggestion is that everyone should learn the wrist-lock dance, and processes for discharge of Anger. Suggesting universal Wrist-Lock dance training could be expected to meet some moderate to stiff resistance.
I'm assuming this is in reply to my post, but it doesn't seem to address many of my specific questions.
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text:
tag:blogger.com,1999:blog-367685842016-08-25T14:22:36.221-04:00Omics! Omics!A computational biologist's personal views on new technologies & publications on genomics & proteomics and their impact on drug discoveryKeith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-2158838208990651032016-08-20T09:37:00.002-04:002016-08-20T09:37:29.275-04:00Where the bleep did my pores go??
Another afternoon spent this week in the lab, and another awful MinION run. I figured that the last run was eminently beatable, given that I ended up with exactly one read aligning to my reference (though perversely, re-calling the data via Metrichor ended up with two reads in the pass folder -- one of which had zero bases in it -- I guess it is a passing null read). But no, despite coming close to being botch-free on the routine lab stuff, dark clouds came early and the experiment yielded not a single usable read.

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-9961745624562051002016-08-03T23:43:00.003-04:002016-08-03T23:43:47.803-04:00Sometimes It's More About the (1D) JourneyI will confess that I had a post planned in advance of which this post is but a faint echo. A grand scheme was going to yield a triumph worthy of brass bands. But instead, it's barely kazoo territory, but sometimes even a small victory must be celebrated, if only in moderation.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-67593891243731734552016-07-19T23:47:00.000-04:002016-07-19T23:47:43.325-04:00Math Toys, Much Enjoyed!Last week, I attended a free public talk at the Society for Industrial and Applied Mathematics (SIAM) here in Boston. This is a wonderful public outreach concept which too few conferences sport. The speaker, Tadashi Tokieda of University of Cambridge, illustrated a number of fascinating phenomena which can be demonstrated with simple toys or household objects. Tokieda didn't lecture from a bunch of slides; most of the talk was in the form of live demonstrations -- and demonstrations made with overt glee! There's a Storify of the entire meeting, in which mine and others of the Tokieda talk can be found.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-56501364771689263172016-06-21T23:37:00.001-04:002016-06-21T23:37:50.429-04:00Infinity's Sad RUDAlmost five years ago, I wrote of voluntarily leaving Infinity Pharmaceuticals. Particularly due to the novelty (for me) of the voluntary part, at times I've wondered how long I would have stayed there. Indeed, the offspring asked just that question just over a week ago. I do know now when I couldn't have stayed any longer, as to my great dismay Infinity announced last week it was discontinuing its Discovery operations due to a disappointing drug trial result.

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-9677383135030328822016-06-16T23:56:00.000-04:002016-06-20T10:29:21.761-04:00Writing BigFor the past few decades, since the early stirrings that led to the Human Genome Project, technology for reading DNA has gotten immense investment and attention. Particularly noted, perhaps ad naseum, is the rapid decline in sequencing costs which outpaces Moore's Law for microprocessors. The converse activity of writing DNA has generally played second fiddle, but these past few weeks have seen a flurry of headlines on that topic.

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-41994991873833413572016-06-10T09:00:00.001-04:002016-06-10T09:07:05.163-04:00London Calling 2016: Further Thoughts
London Calling was two weeks ago, and I still haven't written anything beyond the write-up of Clive Brown's talk (note that many of the talks are now view-able via Oxford Nanopore's website). I did finally make some headway on Storifying the tweets. After several self-inflicted wounds (starting with failing to read my write-up of the previous experience of trying to post to Storify from the command line, but also from failing to record the details of that final critical command), I did succeed. This time I decided to group the tweets into several broad categories -- with tweets potentially showing up in multiple categories, though these are a bit rough-and-ready and probably most folks will want to check multiple or all of the stories. One major value I derive from this exercise is having them to refer back to, so I'll probably feel the pain of erratic characterization the most (though I also have the tweet database, so I could reslice these in new ways). Anyway, the categories are: de novo Assembly, Bioinformatics and R9, Real Time and Read-Until, PromethION, Microbiomes, Clinical/Human (except Infectious Diseases), Infectious Disease and Biowarfare, Field Uses plus finally Library and Sample Prep (another one that failed initial upload; includes Zumbador and VolTRAX tweets).

There's supposed to be a final one encompassing everything that was left over, particularly general tweets about the conference. Unfortunately, Storify balked at that one -- have to look again and perhaps break the set into at least two pieces. (nope: worked with one)

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-50069400904987272552016-05-29T20:09:00.000-04:002016-05-31T08:39:36.764-04:00London Calling: Notes on Brownian CommotionI'm behind on writing up London Calling. I can partly blame a failing computer -- though rebooting it seems to have righted it for the moment. A bigger challenge is that I had the luxury of staying in London thru the weekend, and have been trying to pack as much in of England as I can. To really do justice to everything, I need to scan all the tweets -- and that will take some time.

But I have dug into everything around Clive Brown's talk (kudos to NextGenSeek for Storifying that portion of the meeting's tweets!_ about the current and future state of the Oxford Nanopore platform, so I will focus on that, with a few side-trips on closely related topics. A few gaps on topics I previewed but didn't show up in the presentation were filled in with chats with Clive. Plus, the indescribably huge advantage of actually going to a conference are the tidbits gleaned from late night chats over drinks (and no, I didn't ply anyone to get them to spill -- all was coughed up out of pure free will). I'm going to roughly divide these by the announced timeframe: now, imminently, later this year, perhaps next year and unspecified.
Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-83312819282586356992016-05-25T21:25:00.000-04:002016-05-25T21:25:10.222-04:00London Calling PreviewON Thursday and Friday this week Oxford Nanopore will be holding their second annual London Calling meeting. I successfully defended my schedule this year, so I'll be on the ground there. If you follow me on Twitter and don't want to be buried in nanopore tweets, mute the hashtag #nanoporeconf (a rather large hashtag for talking about nano stuff!) LC is OxNano's premier event, so what might we see from the company?

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-52032774012537345012016-05-24T10:36:00.000-04:002016-05-24T10:36:33.310-04:00Inconstant linesIf you order chemicals, then the supplier provides a certificate of analysis, which shows the amounts of impurities or their limit of detection. Fir physics experiments, one can purchase components which have been carefully cast or machined to precise dimensions. Barring errors by the manufacturers, these reagents and components can be relied upon, as their consistency is known. Alas, for biological systems, such constancy is often a mirage.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-20718793959170225502016-05-22T23:42:00.004-04:002016-05-22T23:42:49.924-04:00Sickle Cell Anemia: An underprioritized disease?The Sunday Boston Globe today had a front page piece by STAT's Sharon Begley that asks some challenging questions about prioritization of disease research. Poking around the STAT site, I found that the original article was even longer and better, but between the important issues it raises, some interesting peripheral stuff and at least one gaping hole, there's plenty to discuss.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-17885563244733465112016-05-20T06:12:00.001-04:002016-05-20T06:12:27.156-04:00Kendall Square Tech/Biotech/Biopharma Needs to Get Vocal About Transit!Earlier this week, the current big Boston-area mass construction transit project, known as GLX, went through a near-death experience. The project, having been mismanaged to be over budget and behind schedule in the early going, was approved to survive in a stripped down form. Numerous political types were quoted supporting the project, albeit complaining about contributions their towns were making to keep the project alive. What wasn't heard was any sort of support from the tech, biotech and biopharma companies which crowd Kendall Square.

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-18869566842634781752016-05-18T23:39:00.001-04:002016-05-18T23:39:08.117-04:00Exploring Critiques of Siddhartha Mukerjee's The Gene, An Intimate HistoryMy finely tuned skills in the art of procrastination KOed my plans to see Siddhartha Mukerjee's talk tonight at a local bookstore (apparently with Henry Louis Gates) to promote Mukerjee's new book The Gene: An Intimate History -- the event sold out. Perhaps I could have found a scalper, but I decided I'd just head home. Mukerjee's first book, the cancer history The Emperor of All Maladies, was very well received (even spawning a PBS series), and I was impressed that Mukerjee took the time to contact me after I wrote a review in this space. The new book has been taking quite a bit of criticism, and even more so his New Yorker piece that preceded it (and I assume is derived from a portion of the book).

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-34351461756689147712016-05-06T21:41:00.001-04:002016-05-06T21:44:44.491-04:00Around the World in Amino AcidsThis post is pure whimsy, growing out of killing time on a train ride. The not-so-serious question: what is the geography of amino acids? If I search for them by name in Google Maps, what will I find? With just Google Maps, plus some Google Translate thrown in, I found a few surprises.
Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-44775653815839486942016-04-28T21:51:00.000-04:002016-04-28T21:51:06.196-04:00Genia Publishes Platform ProgressNanopore sequencing developer Genia published in PNAS last week a study demonstrating the basics of their current approach to sequencing. I say current, because Genia has gone through a number of iterations and on at least two occasions promised to be going into beta in a 6-9 month timeframe. The paper demonstrates the basic concepts of a sequencing system and generates some short reads, but also suggests that Genia won't be hitting beta sites in the near future either.
Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-34930947612467709882016-04-05T23:13:00.002-04:002016-04-05T23:13:33.595-04:00Protein Homeostasis: Has it Hit The Classrooms Yet?I wrote a piece earlier this year suggesting that introductory Biology textbooks should emphasize protein complexes more. My basis for assuming that they generally don't isn't very good: a single textbook in use in TNG's high school class, which sports a copyright date from a decade ago. I also remember what I was taught in high school and college courses, which I would rate as not bad and truly excellent (respectively), plus I was a teaching fellow for one semester of intro bio at Harvard. I now have another suggestion to cram into every biology course: an overview of ubiquitin-proteasome system.

Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-91382024052990448962016-04-03T23:36:00.001-04:002016-04-04T06:27:23.503-04:00Mosquito Genomes: Chance for Long-Range Companies to ShineFriday's New York Times carried a front-page illustration of the current status of the Aedes aegyptii genome, accompanying an Amy Harmon story on efforts to improve the currently highly fragmented state of this genome

Hey @DrKatHolt @rrwick, there's a Bandage plot on the front page of the @nytimes today! #NoFooling @MarkKunitomi pic.twitter.com/a1n6QyQWr3
— Adam Phillippy (@aphillippy) April 1, 2016

The pice has seen a lot of opinion on Twitter with regard to its value and other issues (such as calling an assembly a map -- which to me is correct as the perfect genome sequence is the ultimate physical map!)

This whole thread. My science peeps keep me here. ❤ https://t.co/96mifMD0da
— a muse (@_a_muse) April 3, 2016

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-43342963891552437242016-03-31T22:02:00.000-04:002016-03-31T22:02:23.438-04:00Reflections on And The Band Played OnFellow blogger, colleague and science history buff Ash pointed out to me recently that Randy Shilt's And The Band Played On for Kindle was on sale. I hadn't read the book, nor seen the miniseries, so I snapped up a copy. It's a good read -- though at times a hard one - I don't believe I've ever read another work of non-fiction where such a high fraction of the named individuals are dead by the end of the book
Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-28067293473573190732016-03-30T23:37:00.001-04:002016-03-31T22:20:28.374-04:00Who Wants To Write A Review Article?Yes, this is a solicitation. I'm on the Editorial Board of the journal Briefings in Bioinformatics,. I'm looking for authors who would like to write high-quality, compact reviews. If you are interested, or you want a little back-story, then keep reading.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-68113005111837516532016-03-29T21:18:00.002-04:002016-03-29T21:18:27.753-04:00At the Edge of The CloudI've used cloud computing at Amazon Web Services (AWS) off-and-on now for over five years. The cloud has all sorts of handy advantages -- flexible access to large amounts of compute, inexpensive access to any flavor of Linux you wish, the ability to guiltlessly kill a huge server you just fatally cratered with the wrong command. And until now, I''ve always been able to find machines that fit my needs -- perhaps sometimes just fitting or with a bit of compromise But, now I've hit the wall: nobody at this time offers a really serious cloud machine with 500Gb of RAM.

Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-53294282042516016052016-03-25T20:56:00.000-04:002016-05-23T08:58:39.368-04:00Selective sequencing: A Programming Opportunity!I ask a bit of indulgence from my regular readership for this piece, as I am going to explain a number of things in depth that probably will be very familiar to them. My hope, perhaps fantastic, is that this piece will get out to some who are not so familiar with such topics, as I think the problem at hand might be very fascinating.
Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-83738853749374359042016-03-18T07:12:00.000-04:002016-03-18T07:16:16.038-04:00PacBio's big splash[18 March 2016 -- my original inclusion of the Pac Bio marketing image 6 years ago was claimed to be a DCMA violation -- I've simply removed it, though I do think this would fall under fair use ]

The Pacific Biosciences instrument is officially unveiled now, with those lucky/smart (or SMRT?) enough to go to Marco Island filling in all of us not in that position. Sounds like a great lot of hoopla, though they didn't drag the Hornet for the splashdown.

First of all, it's a beast. "In this corner, weighing in a nearly an imperial ton...". Too bad their marketing picture has nothing good for judging the scale --
it's apparently 6.5 feet wide.

Kevin Davies at Bio-IT World has a wonderfully detailed article and there is a lot of nuggets in the Twitter feed. Anthony Fejes has two different sets of notes out -- one from a workshop and one from another speaker; Dan Koboldt has some good notes too (and if I haven't shouted out your notes, it's probably because I'm oblivious -- leave me a comment pointing to them). There was also a little bit of PacBio science in Elaine Mardis' talk (she's on their SAB) -- Anthony's notes & the twitter feed.

Okay, besides worrying about the capacity of floors & freight elevators, what's new? Well, not much on error rates from PacBio (apparently in the Q&A their presenter executed a jig, tango, waltz & rumba when asked) -- though the Mardis talk described resequencing samples of PacBio that had been done before by Illumina -- and the results are quite good. Another important note is that their system doesn't seem to have much bias in terms of composition -- bias against hi/lo %GC has been noted in all of the amplification-based systems and can be a serious problem.

There's also a lot of talk about being able to distinguish various modified bases by their effects on polymerase kinetics. PacBio has also demonstrated direct RNA sequencing (substituting a reverse transcriptase for DNA polymerase) and is talking about watching proteins being made. I haven't quite figured out why you'd want to do that last one, but presumably it's for more than a cool Nature cover.

Read lengths decay exponentially -- but with lots around 1Kb and quite a few around 5K. The big problem is apparently oxidative damage to the polymerase triggered by the laser -- so they are working on both getting the oxygen out of the system and engineering hardier polymerases (the sort of biz I used to be in). Their strobe sequencing mode -- in which the laser is turned off to enable elongation in safe darkness -- enables multiple reads separated by long gaps.

The instrument definitely raises the bar on sample prep -- it's apparently entirely automated within the monster. YEAH! A machine I can delude myself into thinking I could run it! One drawer takes the SMRT cells and another the DNA samples -- 500 ng of each. That doesn't sound like much (it's at least better than the 5-10ug most library prep protocols call for -- except the ones looking for 20-30ug), but it seems you don't get a lot from each sample.

The number of reads per cell isn't huge -- but you're still getting about 2 E.coli genome equivalents by my calculation. This is a bit undersized for a lot of applications -- but grand from many others. Mardis' talk discussed using PacBio for sequencing PCR amplified resequencing samples -- this would appear to be right in the PacBio sweet spot. Perhaps a few hundred long PCR products could be packed into one SMRT run and still get many hundreds of reads per sample -- well, maybe pack fewer amplicons.

What might be other good uses? Clearly metagenomics and similar. I just saw a posting on a professional board of someone pondering multiplexing hundreds of samples for an Illumina run (the current barcode schemes are for a few orders of magnitude fewer samples). Blitzing each sample through the PacBio instrument would seem to be obvious -- if the error rates are acceptable. Folks doing whole genome sequencing of small genomes will love having PacBio to generate scaffolds. For bigger genomes, it may just still be too expensive to get much coverage ($100 a SMRT cell sounds cheap, until you start multiplying that out for the numbers you need) -- but perhaps not (much too fried to do that calculation at the moment).

RNA-Seq might be a bit trickier. If you need 500ng of input material, that's an awful lot of ribosome-depleted or poly-A RNA. Plus, getting only tens of thousands of reads, making it hard to see lowly-expressed messages -- but very long ones, perhaps priceless. But, if you can get tons of RNA, then 100 SMRT cells would be about $10K and offer similar depth to what you can get today with Illumina but with those super long reads.

Now, who is this going to crimp the most? The instrument is clearly a ways from really threatening Illumina & SOLiD for the large genome market. 454 is a likely candidate to see growth pressured -- though between the new lower-priced "junior" and both PacBio's $700K price tag and their inability to flood the market with instruments, this will be ameliorated.

PacBio might have almost as much effect on the surrounding sequencing ecosystem. Making library prep reagents for this system is not going to make you lots of money! But, there will be a serious niche for targeted sequencing -- though with the scale it will probably require some rethought. Stuffing the whole exome into this doesn't really make sense -- if there are ~250K segments of the genome to read & you want 40X coverage of each, that's a lot of SMRT cells. But, intelligently chosen gene sets totaling about 500 regions (or around 20-50 genes) with pre-validated reagents -- now that might be a market (though one which might have 1-2 years of life -- better get cracking!). Simpler library prep will also go nicely with some of the enrichment systems -- a bugaboo of hybridization systems can be "daisy-chaining" of fragments via the amplification adapters -- but, on the other hand you don't get 500ng off an array or in-solution system without amplification. As with many disruptive technologies, it won't fit a lot of bills but will nibble off various parts of the business that are individually small but significant in aggregate. As noted above, RNA-Seq might be an initial success story for PacBio -- when RNA is abundant.

IMHO, PacBio does need to get some papers out on applications (Mardis' group apparently is close to having one) and make sure that the next tranche of installations not only includes the Sanger & BGI, but that there are also some core labs or commercial providers. Also, they need to start pumping data into the public domain -- while they signed a bunch of commercial software providers up, it is definitely out of academia that you find the most radical advances. Plus, there are a lot of now well-entrenched open source tools that need to be tested with the new kid. Even simple things like the semi-standard SAM/BAM format are going to need tweaking -- SAM/BAM stores all sorts of information on read pairs, and the strobe sequencing can generate many more than 2 tags per DNA fragment.

Of course, we have to wait another half day plus to find out what Ion Torrent is really delivering. That could really shake up the landscape -- at least the mental one.

A huge thanks to all the bloggers & twitterers for pouring out so much information. I'm still getting used to scanning past the retweets (is there a way to condense them) and there is the occasional shock-to-the-system (how could anyone in the field not have heard of Rodger Staden?!?), but that's a tiny price to pay for such fascinating stuff.

Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-2632741201130039902016-03-14T23:56:00.001-04:002016-03-14T23:56:18.377-04:00A Mosquito ExAC?Okay, there's a scheme for a crazy big genomics project has bitten me, infecting my brain. It's definitely not something I'm in a position at all to execute on, but I throw it out as an idea in case anyone finds it useful. And admittedly, it is pretty much stealing straight from the ExAC human exome aggregation project, which contains huge numbers of human exomes. Behind all those is a lot of phenotype data. Now, inspired by recently re-reading Laurie Garrett's The Coming Plague and also faced with daily news items on the Zika virus epidemic, I've had this question: what if the same approach were applied to key disease vectors?
Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-59589103489915794032016-03-09T22:57:00.001-05:002016-03-09T22:57:25.941-05:00Oxford's Riposte To Illumina Trade ActionAlong with the "No thanks, I've already got one" online session, the other big Oxford Nanopore news is the public release of Oxford's response to the trade complaint filed by Illumina which was attempting to exclude all Oxford Nanopore devices from the U.S. markets. Nature News' Erika Check Hayden has posted the document on Dropbox, which was a big help. While no documents from Oxford's side concerning the simultaneous patent lawsuit have yet surfaced, it is reasonable to expect that it will use many of the same arguments.
Read more »Keith Robisonhttp://email@example.com:blogger.com,1999:blog-36768584.post-12266543418063012762016-03-08T23:19:00.000-05:002016-03-08T23:19:33.369-05:00Oxford's "No thanks, I've already got one"

Oxford Nanopore today hosted a Google hangout titled "No thanks, I've already got one". Only this morning did it occur to me I could have re-watched Monty Python and Holy Grail and scored it as blogging-related time! Oxford CTO Clive Brown went through a number of interesting (and in many cases, long-awaited) announcements on the release of multiple key upgrades to the platform (note: unless otherwise specified, images swiped from ONT).
Read more »Keith Robisonhttp://firstname.lastname@example.com:blogger.com,1999:blog-36768584.post-35745923807091282922016-02-25T23:00:00.001-05:002016-02-26T06:46:45.222-05:00Digging into the Illumina Lawsuit vs. Oxford NanoporeIllumina's and University of Washington's filing of a patent lawsuit and related trade complaint against Oxford Nanopore made big news yesterday, with nice coverage from Mick Watson, GenomeWeb, Nature's Erika Check Hayden, Technology Reviews' Antonio Regalado, BioIT World's Aaron Krol, and venture capitalist Vishal Gulati. Each of these covers the onetime partnership between the two companies and their acrimonious parting of ways. Oxford Nanopore released a short and pithy response. Having failed to get an early jump on things, the ground is already well plowed. So my sloth and inertia have forced me to take an unpleasant route I usually spend great effort avoiding: actually reading the complaints and the two key patents licensed from Jens Gundlach's group at University of Washington (US8673550 and US9170230 ) they cite.

Read more »Keith Robisonhttp://email@example.com


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- Report: #1004693
Report - Rebuttal - Arbitrate
Complaint Review: national association of business leadership nabl
national association of business leadership nabl100 Eagle rock ave Nanover, New Jersey United States of America
national association of business leadership nabl I paid premium every month and nabl didnt pay my medical bills.I was left with alarge medical bill to pay and that not right . y Nanover, New Jersey
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I paid premium every month .I call them and all you get is the operator that tell you they will start paying bill in a few week,now its over a year no bill been paid no premium return.
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Overland Park, Kansas, police have released surveillance pictures of two men suspected in multiple cellphone thefts from kiosks at Oak Park Mall.
Police said they have taken nine different theft reports involving the men.
Authorities ask anyone who can identify them to call the TIPS Hotline at 816-474-8477.


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Times Software Pte Ltd offer a range of integrated products -Times Pay/HR software and web based solutions can be used to streamline payroll and HR processes and to provide a more cost effective total solution. In today's advance technology and Internet information age, HR departments are required to react quickly to implement new technology to cater for high expectations of managers and employees.
We provide comprehensive functionality to help company to achieve automate labor-intensive processes and real time transaction to managers and employees. HODs or managers will have more time to focus on more challenging Financial and HR Functions in order to be part of organization strategic partner.
We are one of the leading software company offering single database integrated with Payroll and HR, E-Leave, E-Timesheet as well other employee self services module such as E-Claim, E-HR, E-Recruit, E-Payslip, E-Appraisal, E-Training (PD), E- Booking, etc.
Our Profile
Awards-HR Vendors of the Year 2015
- Voted by HR Practitioners as Singapore Preferred Payroll Software Vendor of the Year 2015
- Voted among the top HR Vendors of the Year for 10 consecutive years from 2006 -2015
- Singapore SME 1000 comany by DP Information Group
Enhanced Paternity Leave and Itemized Payslip Update
We would like to announce the release of our latest patch to comply with the 2 new government regulations announced in the past months:
- Government Paid Paternity Leave
- Mandatory Itemized Payslip
Do email us at email@example.com if you have yet to receive the updates!
Year End 2015 Workshop Grand Draw Winners
Provide an integrated application with comprehensive Payroll HRIS functionalities that manage multi-countries databases, support multiple currencies and languages with flexible and robust electronic document management.
Enabling true employee empowerment and HR automation.


text:
I did this on a few boards but more as a Secret Santa type thing.
Would anyone be interested in doing a registry swap? You are matched with someone and they pick something (usually $25 or less) off your registry and you pick something of their registry and have it shipped to them. No need for addresses to be shared because the registry has that info.
Megan =)


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News flash: you can't carry guns — unloaded or loaded — onto airplanes. And yet last year, Americans packed more firearms in their carry-ons than ever before, the Transportation Safety Administration says, most of which were loaded. [More]
TSA: More Guns Seized In 2015 Than Ever Before, Most Were Loaded
Customer Turned Down For Loan, Threatens Kia Dealership With Handgun
There are many ways to deal with the situation when you're turned down for a car loan. You could, for example, try a different dealership, or apply for financing through your own bank or credit union first. We do not recommend the tactic that one man in Kansas took last week, which was to pull out a handgun and threaten Kia dealership employees with it. [More]
Walmart, Sears, Amazon & Other Retailers Agree Not To Sell Realistic-Looking Toy Guns In NY
Almost eight months after New York Attorney General Eric Schneiderman sent cease-and-desist letters to several retailers including Amazon, Walmart, Sears and Kmart, those companies have agreed not to sell realistic-looking guns in the state.
Hackers Can Now Remotely Attack A Gun, Change Its Target, And Lock The Owner Out
Over the past few years we've heard a lot about the smart, connected devices that make up the internet of things. From ceiling fans to cars and cameras, they're everywhere. Unfortunately, anything that can connect to the internet can be hacked through the internet… and now, it seems, that includes guns.
Man Arrested After Police Say He Stuffed An AK-47 Down His Pants
The AK-47 is many things, but it is definitely not a small and discreet weapon. That's why it's not surprising that a man in Florida was arrested after trying to shove one of the assault rifles down his pants in a pawn shop, evidently thinking that this was something he would be able to get away with. [More]
Supreme Court Says Convicted Felons Have A Right To Sell Their Guns
Plenty of Americans legally own firearms. If any of them are later convicted of a felony (that isn't related to the weapons) and can no longer own a gun, should they have the right to have some input on where their former firearms go? According to the U.S. Supreme Court, yes. [More]
TSA: 2,212 Firearms Found In Carry-Ons Last Year, And Most Were Loaded
Although the average traveler should know by now that flying with guns in your carry-on bag is not going to fly with the Transportation Security Administration, the number of people trying to bring firearms through airport security is going up every year, the agency says in a report today.
Delta Employee Arrested After Allegedly Helping To Smuggle Guns On Flight
Perhaps the Transportation Security Administration's recent reminder that guns aren't permitted in carry-on bags should have explicitly stated that this rule also applies to airline workers. But we doubt that would have stopped a Delta baggage handler from allegedly smuggling more than 100 guns onto flights with the help of a former co-worker.
Reminder: TSA Has Magic Machines That Will Find Gun Parts Hidden In A PlayStation 2
This just in: X-ray machines used by the Transportation Security Administration have the power to see through plastic — yes, even the plastic used in gaming consoles! — and will be able to detect the presence of things that should not be in your carry-on bag. One traveler recently foiled by the TSA apparently thought all the camouflage needed to hide gun parts was a Playstation 2.
TSA Would Like To Remind Everyone Flying For The Holidays That You Can't Bring Guns In Your Carry-On
After a record year finding guns in travelers' carry-on bags at the nation's airports, the Transportation Security Administration wants to take a second to remind everyone flying for the holidays that weapons need to be in your checked baggage and declared to authorities. [More]
Panera CEO Asks Customers To Leave Guns At Home
Target Asks Shoppers Not To Bring Guns Into Its Stores
Target added its name to the list of companies asking customers not to bring guns into its stores. [More]
Target Security Officer Finds Loaded Gun In Toy Section
Playskool makes a wide variety of fun and adorable products, but they don't make a 9mm Lugar pistol. Yet a Target employee found a loaded gun sitting out in the toy department last Friday, and want the public's help to find a man who was in the toy department acting in a suspicious manner around the time that the gun was left behind. [More]
Response To Chipotle's "Please Don't Bring Guns" Statement Is Predictably Divided
Another chain eatery has put itself in the middle of the debate over gun rights after Chipotle announced yesterday that it would rather its customers didn't bring firearms into their stores. Not surprisingly, the response to this decision has resulted in praise and condemnation, with little in between. [More]
Man Arrested At Airport Security: Wait, You Can't Bring Guns In Your Carry-On?
There are some things you can see often without really seeing it, ya know? Like the plethora of signs at any airport anywhere telling you not to bring weapons like guns, knives or throwing stars on the plane. Maybe one guy just saw those too often — or not enough — as he reportedly didn't know you can't bring a handgun through airport security in your carry-on. [More]
Connecticut Walmarts Charged Sales Tax On Tax-Exempt Gun Safes
Since 1999, shoppers in Connecticut have not had to pay the state's 6.35% sales tax on gun safes and other firearms-safety items, but someone forgot to tell the Walmarts of Connecticut, which have been improperly charging the tax to customers. [More]


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Located on the peninsula with 15 hectares of garden and a private beach.
This superb Belle Époque hotel is one of the choicest on the coast. The best of these luxuriously appointed rooms overlook the garden and the magnificent pool. Private beach.
US and Canada: 1-800-780-5733 Europe: 00-800-11-20-11-40 Promo Code 189391
Customer service: Manage your booking


text:
Reviews - Dunster Castle Hotel4
High Street, ,, Dunster, TA24 6SF
Price From 224.97 AUDView Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
82% would recommend it to a friend
Customer service
Food quality
Room quality
This was a very good weekend away.
From the warm welcome on arrival to the time of departure it was a pleasant experience. Dunster is a gem, a time warp, and the hotel is right in the middle of it, offering comfort, good food and friendliness.
Read More Less
You get what you pay for
We paid £70 for a nights accommodation, as this was for one night only we did not wish to upgrade to £125.
The room was incredibly small and the double bed filled the room. The bed itself was most uncomfortable - the mattress being past its best. We have dinner in the restaurant which was lovely but the table was not clean being really sticky. The young man who checked us in was very helpful but he seemed to be jack of all trades doing everything.
Read More Less
Very good
Helpful staff, excellent food.
Excellent hotel, great value.
Friendly staff and owner, clean comfortable and great value accommodation.
Gem in Dunster
Delightful stay started on the hottest day of the year fan produced at once.
Small room but good bathroom.
Read More Less
Dunster Castle Hotel
Room was shabby.
Lovely hotel
We enjoyed our stay very much and found everybody very helpful and everything very nice.
Great hotel
Good location, great food and wonderful hospitality
Dunster Castle Hotel
Excellent room.
Beautiful room and lovely location
We had a lovely time the owners were very friendly and we were upgraded on arrival as it was our anniversary.
The room was beautiful and the breakfast was very tasty.
Read More Less
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text:
I'm a newbie -- so thank you ahead of time for your patience and help.
I have a static page on my website.
Want to link to it via a post.
So I am doing a 302 redirect from the post to the static page.
So I am clicking "make redirect active."
In "redirect URL" I am inputting the url for the static page.
And for type of redirect I am using 302 permanent.
Am I doing that right.
And my question is -- should I also check the "nofollow" box? What would that do?
Thank you.


text:
This may win the dumbbell award, but please tell me if this is correct.
I set a user up as an author and that user must have a WordPress account with the username I specified on the Users screen. To act as an "author" for the site, they log into WordPress, go to the site, and.... ? Or...?
Thanks in advance. I'm sure this is staring me in the face.


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8 things I hate about Online Gamers
©2011 Kent Sobey
Over the last few years I have played a fairly substantial amount of Call of Duty online; mainly in the Modern Warfare series but also, more recently, Call of Duty:
Black Ops. I have come to find that not only do I love the series but I also hate it…
It is not so much the game that drives me mad, but the players. Some of the things I have come across would have had me quit Call of Duty altogether if I weren't so damn addicted. Sadly,
I keep going back for more no matter how much I want to boycott the entire franchise for irritating me so much.
Instead of leaving the game I simultaneously love and hate so much I decided the best way to vent would be to put my thoughts down on paper (so to speak) and give everyone a list of the top 8 biggest irritations for both Modern Warfare 2 and Call of Duty: Black Ops (Online of course).
Some of my points apply to both games and other apply to just one of them.
Multiplayer Misteps Here


text:
Mission Motorcycles Files for Bankruptcy
October 27th, 2015 | by Jo Borrás
Mark Seeger, the CEO of Mission, filed for Chapter 7 bankruptcy on October 15, 2015. Neither Mission Electric nor Mission Motorcycles remains in business
October 27th, 2015 | by Jo Borrás
Mark Seeger, the CEO of Mission, filed for Chapter 7 bankruptcy on October 15, 2015. Neither Mission Electric nor Mission Motorcycles remains in business
October 16th, 2015 | by Susanna Schick
Zero will be presenting their new models at the AIM Expo in Orlando today, and we got to peek behind the curtain so you could be the first to read about it. On Monday we joined a call with Zero's Scot Harden to find out what's coming for 2016. They've made a lot of exciting improvements to the lineup and are introducing two customer-designed bikes, the FXS and
August 7th, 2015 | by Guest Contributor
Originally published on CleanTechnica. By Mike Barnard What is the fastest production motorcycle in the world? What bike beat every [&hellip
December 2nd, 2014 | by Susanna Schick
Susanna Schick got to ride Harley-Davidson's LiveWire electric concept bike, getting a firsthand look at Harley's first electric vehicle. Would you buy it
September 3rd, 2014 | by Christopher DeMorro
Electric cars may have finally reached the tipping point where society en masse begins moving towards them, at least in [&hellip
August 22nd, 2014 | by Christopher DeMorro
Iran wants bring some 400,000 electric motorcycles and 120,000 hybrid taxis to the streets of Tehran, and eventually only EVs will be allowed on in the city
August 8th, 2014 | by Susanna Schick
Hollywood Electrics, the world's leading electric motorcycle dealership, takes on Brammo and announces a grand opening party to be held August 16th
July 29th, 2014 | by Susanna Schick
We ride the Ducati of electric motorcycles, the Energica Ego, through the canyons of Malibu. It's love at first twist as the bike handles beautifully
July 28th, 2014 | by Susanna Schick
The 2014 Zero SR with a Power Tank has the most range of any electric bike. But what's it like to ride? I rode it everywhere, and these are my thoughts
June 19th, 2014 | by Christopher DeMorro
This morning the Harley-Davidson LiveWire electric motorcycle broke cover. Yup, Harley Davidson is building and electric motorcycle
June 9th, 2014 | by Christopher DeMorro
Last week John McGuinness rode a Mugen electric motorcycle to a new record at the annual TT Zero race on the Isle of Man...and now we have the video
March 20th, 2014 | by Jo Borrás
Since 1907, competitors have flocked to a tiny British island called the Isle of Man. This is what the island looks like to on of them, riding a Honda CBR600 to podium
February 15th, 2014 | by Jo Borrás
Next year's Isle of Man motorcycle race will once again feature electric motorcycles. This year, though- and, for the first [&hellip


text:
CDC Director Dr. Tom Frieden
What we're doing about the Zika virus
Zika Action Plan Summit Presentation
CDC Behind the Scenes: Biggest Challenges in Public Health Today
Director of the CDC, Dr. Tom Frieden, elaborates on the biggest public health challenges facing the U.S. and the world today.
These include infectious diseases like HIV and the spread of antibiotic-resistant bacteria, and noncommunicable disease issues like blood pressure, obesity and tobacco use.
He also touches on lessons learned from the Ebola crisis, flu season, and the importance of encouraging more baby-friendly hospitals.
Spotlight:New Orleans Prepares for Zika
In New Orleans, local experts collect mosquitoes for virus testing as part of a citywide mosquito surveillance program.
- Page last reviewed: June 7, 2016
- Page last updated: June 7, 2016
- Content source:


text:
- Report: #868275
Report - Rebuttal - Arbitrate
Complaint Review: Champion Schools
Champion Schools7900 S. Jesse Owens Parkway Phoenix, Arizona United States of America
Champion Schools Fit Kids, Summit Elementry Abusive School Administrators Phoenix, Arizona
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money flowed into the school the "ego's" started to become a problem. students was given a referral for wearing the last
years uniform at the beginning of the school year (the logo slightly changed), students was sent to in school suspension for wearing the wrong shirt (same logo issue).
Teachers (3rd grade) are unable to guide a student to be successful. Public shaming the students seems to be the
best method. Parents are also ridiculed when they try to stand up for their children, and handbook policies are ignored. This school needs to work with the parents "together" to form a plan to guide children to become successful. If a child is not listening to a teacher or being defiant then its best to work on the problem and not get frustrated with the child pushing them down the path of humiliation and kicking them out of school. My child has not been in any fights or other overt bad
behavior, she just has trouble reading and gets frustrated in class, making her shy away from questions and talking, she also cry's out loud if things are taken from her in a rough manner. For some students 3rd grade is tough.
This report was posted on Ripoff Report on 04/13/2012 02:39 PM and is a permanent record located here: http://www.ripoffreport.com/r/Champion-Schools/Phoenix-Arizona-/Champion-Schools-Fit-Kids-Summit-Elementry-Abusive-School-Administrators-Phoenix-Arizona-868275. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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text:
Pendant Necklace FOLLOW YOUR HEART Silver Plated Chain
Our Price: $4.99
Retail Price: $6.99
You save 29%
Item SKU: 1211A
Ask a question about this product
Why you'll LOVE this item:Inspiration, friendship necklace to wear and share ~ Follow Your Heart. Message embossed on both sides of lead and nickel-free cadmium-free silver plated pewter charm. Includes 18-24" silver-plated clasp necklace chain. Chain style may vary: Box chain, ball chain or snake chain. Please e-mail us with chain preference ~ we'll do our best to match the style you'd like. Ready to give in a pretty organza bag.


text:
Hi, I've a Nextgen sidebar widget on my site and I'd like to link it to a another external website that I have. I'm having difficulty in trying to find a way to put a URL link so someone can just click on the image and another tab / window opens up for the other website, can anybody help me on this one.
Many thanks in advance.


text:
An Introduction
The Socialist Labour Party was launched by leading trades unionists and campaign activists at its first congress on May Day 1996. The congress was called a year after Tony Blair's 'New' Labour abandoned any commitment to progressive change for socialism in Britain.
However, the SLP is far more than a reaction to developments in the Labour Party. Socialist Labour aims to build on the heritage of all the movements of resistance to the free-market offensive in Britain over the past two decades. In particular, it is the political heir of the year-long miner's strike of 1984-5 and of the tremendous movement of solidarity it inspired in all sections of British society.
Follow us on twitter
Follow us on facebook
click HERE to watch VIDEO of Arthur Scargill's latest speech 'vote leave' June 2016, Birmingham
Photo: the SLP out in force at the Durham Miners Gala
Unlike the 'mainstream' parties Socialist Labour does not have powerful multi millionaire backers but relies on donations from it's members and ordinary working people who support the party's policies and aims. We need funds to continue and develop the campaign for a socialist Britain. We are grateful for all contributions. If you are able to donate to our fighting fund you can send a cheque or postal order to: the General Secretary, Socialist Labour Party, PO Box 193 Liverpool L38 0WX. Cheques should be made payable to "Socialist Labour Party".
If you would like to support the party with a regular donation you can print off a standing order form by clicking HERE