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Air & Climate Companies in Luxembourg
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Deloitte & Touche Sustainability Services
Office in LUXEMBOURG
Deloitte Global Environmental Services offers a comprehensive approach to managing the risks and opportunities related to environmental and social issues. We partner with clients to develop leading edge tools and methodologies.
PONSEL - Aqualabo Group
Distributor in LUXEMBOURG
PONSEL MESURE manufactures instrumentation for water quality. We provide practical solutions to all professional working in wastewater, drinking water, scientists involved in field and laboratory conditions. PONSEL was founded in Versailles, France, in 1948 by Laurent PONSEL. With 4 engineers, PONSEL worked with researchers and the first institutes in field of agriculture ...
based in Wiltz, LUXEMBOURG
BlueSphere is a consulting services company focused on Environment, Health and Safety integrated solutions. Committed to deliver innovation, BlueSphere collaborates with its clients to help them improve the return on investment with high-performance applications. At best, our clients will know their Energy consumptions and costs allocations. With more, they will be ready ...
Paul Wurth S.A.
based in Luxembourg, LUXEMBOURG
Headquartered in Luxembourg since its creation in 1870, Paul Wurth has transformed itself over the last decades into an international engineering company. As a result of its considerable know-how and its effective policy of innovation, the Paul Wurth Group is today one of the world leaders in the design and supply of the full-range of technological solutions for the iron ...
Phenomenex, Inc.
Office in LUXEMBOURG
Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, clinical, government and academic laboratories. From drug discovery and pharmaceutical development to disease diagnosis, food safety to environmental analysis, Phenomenex chromatography ...
Larson Davis, a division of PCB Piezotronics
Office in LUXEMBOURG
Larson Davis, a division of PCB Piezotronics, is a world leader in the design, manufacture, and distribution of acoustic and vibration measurement systems used for environmental noise monitoring, workplace noise/vibration exposure, and general noise surveys. The Larson Davis product line includes products such as Type 1 Sound Level Meters, Permanent & Quasi Permanent ...
BIOROCK S.à.r.l
based in Hautcharage, LUXEMBOURG
BIOROCK was established in 1988 and is now an internationally acclaimed and experienced company leading in (compact) sewage water treatment technology. BIOROCK has a total concept: we have our own R & D, Rotational Moulding Manufacturing facilities and a Worldwide network of Sales & Technical support. The BIOROCK product range can be used to treat sewage from a single ...


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Traxxas replacement idler gear for the Hawk 2, Blue Eagle LS and Blue Eagle LSII. This is the black nylon "middle gear" inside the gearbox.
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An open-access catalog of tens of thousands of human exome sequences highlights the power of a very large genomic dataset in pinpointing genes linked to rare diseases.
Do Patents Promote or Stall Innovation?
June 1, 2016|
A petition recently filed with the Supreme Court triggers renewed debate about the role of patents in the diagnostics sector.


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IB Consultancy Events
26-28 September 2016, Kuwait
Learn about the most vibrant CBRNe market in the world: the Middle East
8-10 November 2016 in Kuala Lumpur, Malaysia
The world's most prestigious CBRNe event is back for its 4th edition
8-10 November 2016 in Kuala Lumpur, Malaysia
Asia's leading EOD, C-IED and demining event is back for its 5th edition
27-29 June 2017 in Sonthofen, Germany
Your portal to the European CBRNe Community. Back for its 4th edition.
September 2017 in Washington DC, USA
The world's #1 CBRNe event series is back for its 2nd edition in the USA!
"NBC-Sys is in relation with IB Consultancy for a long time and we really appreciate the professionalism of its team. NCT CBRNe Asia was a perfect place to increase the network of our company. The approach of IB Consultancy is really business oriented and helps the industrial company involved to be in good position to do business. The organisation of the B2B meetings with the delegates is very helpful to open new markets. Congratulations!"Bruno David, Marketing and Sales Manager, NBC Sys
- IBC events are built around top quality programs, with more and better speakers than any commercial CBRNe or C-IED/EOD event
- We work with you shaping the program, inviting the right participants and adding value to your business
- We ensure participation from relevant end-user organisations, and we invite government delegations to maximize networking opportunities
- IBC events always takes place in either a 5 star hotel or is part of an established exhibition
- Our events are accessible for all, since we use Emerging Market fees for delegates from countries that cannot afford a full delegate fee
- IBC offers the most innovative sponsorship packages in the industry, constantly improving our offering
- IBC events, and its sponsors, are promoted in over 25 publications per event, providing sponsors with visibility like no other event
- Our conference programs are unique and of the best quality. We aim to find speakers who you have not heard at any other conference
- Unparalleled networking during the breaks, our networking receptions or during our gala dinners (for selected events)
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- All refreshments, lunch breaks, drinks receptions and gala dinners (for selected events) mentioned in the conference program are included in your delegate fee


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Manchester United Message Board
leonmathilda leonmathilda Mar 19, 2011 04:59 Flag
Overrated, Underrated and Footballer of the year
Just want to list some players being recognized as underrated or overrated:
Berbatov - slightly overrated, but he has real skill though, albeit a bit flamboyant.
Javier Hernandez - very overrated, especially overrated by Man Utd fans. He scored about 80% of easy goals from crosses i.e. headers, poacher goals, tap-ins. Without all these crosses (Man Utd are specialist in crosses), his impact can be significantly reduced.
Rooney - Extremely overrated. Not that he is a bad player. He is good. But extremely overrated and overhyped by English Media. He scored more than 70% goals from crosses last season, just like Hernandez this season (like I said, Man Utd are crossing expert).
Goals from crosses = mostly easy goals - tap-ins, headers, poaching goals.
Scored a lot of easy goals and people easily think he is the best = overrated
Scored a lot of easy goals + overrated by English Media = Extremely overrated.
If my grandmother were taller and faster than Rooney or Hernandez, playing with Man Utd the cross ball expert, my grandmother could easily be the season-end top scorer by scoring a lot of easy goals from crosses and easily voted the footballer of the year, as long as she were English. LOL.
Talent wise :Berbatov > Rooney > Hernandez
Suitable to the team (cross ball tactics) : Rooney > Hernandez > Berbatov
Thus poor but talented Berbatov being a sub recently.
Gareth Bale - Very overrated. This young kid has potential and fast. But if he were without his speed it looks like he could be nothing. Very overrated by English Media just because the English media don't want Tevez to win the footballer of the year (PFA player's player of the year, voted by players). Neither does Fergie.
The English media always talk about Bale's Hat-trick against Inter and his "fun" on Maicon. But besides that, besides a very few games that he played well, sorry to say, he is nothing. Too young to win the PFA but the English Media want him to win it, because of one guy - Tevez.
Which come to the last footballer that almost every Man Utd fans really hate:
Tevez - underrated, and sometimes very underrated. Underrated by English media. They always use the word "workrate" to describe him but never use the word "talented". But the English media always called rooney "superb", even if rooney just scored some easy tap-ins from crosses set up easily but his teammates.
Tevez - underrated by English media as they don't want him to become the first Argentina and South America player to win the prestigious Footballer of the Year in England soil. They promote Gareth Bale - a 21 year-old kid instead without even consider that Tevez is already 3-times-in-a-row South American Footballer of the year and Brazilian League Best Player of the year. They promote the 21 year-old kid instead. They are biased enough not to want an Argie to win it.
It is about time Tevez wins the honour of Footballer of the year, simply because he is fully deserved to win it compared to others.
But the English Media have other ideas, or agenda. Man Utd fans hate him and don't want that to happen as well. Fergie doesn't want him to win as well because he was not worth 25m pound two season ago. It could be embarrassing a "not worthy player" wins the highest honour.
But I don't think Tevez would care a bit about winning it or not though.Sort: Newest | Oldest | Most Replied Expand all replies
Tenaka1974 Tenaka1974 Mar 20, 2011 00:53 Flag
lol the funniest sh it i have read all year thanks for the laugh leon, now go back to what you know about and that seems fu ck all your knob jockey:)
I don't know who you are, but this has to be poorest thought out post's I have ever seen on here. most United fans on here have tried to keep the lid on our excitement at the impact Chicarito made when he came to us and we thought he was one for the future and not an instant success and though we all acknowledge that he still has room for improvement He has fitted in very nicely and has not been overrated and reminds me in some ways of a new Denis Law.
I cannot pretend that I will forgive Tevez that poster and allowing himself to be used in such a way against fans who took him to their hearts and he knew it. But he can't walk on water either.
And what was all that waffling on about crosses, you obviously know bugger all about UTD so why don't you keep to waht you do know about, whatever that is
United do rule United do rule Mar 19, 2011 13:48 Flag
The thing about Tevéz is that he realises he made a monumental cock-up in leaving the most successful club, and joining the least successful club. I rate Tevéz as a player, but he looked pretty sad out there the other night.


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Like I mentioned earlier I made a bunch of Fettuccine Alfredo for my brother's wedding shower. Well, I went a bit overboard. I made waaay too much. About half of what I made got eaten which was still a lot but now I have more of it then we can eat as is. I mixed the noodles and sauce so no one would be a sauce hog. Any ideas on what to do with all of this? I have about half an aluminum roaster pan left. I don't really like the way noodles turn out after being frozen so I would prefer ideas that involve using it asap.
WWYD: with lots of leftover Fettuccine Alfredo
Comments (7)
Add tuna and peas or chicken and peas? Add broccoli?
Babywearing Educator Postpartum Doula Student Midwife Mama to Chandler (ASD) 12/08 Matilda (ASD) 9/10 & August 2/13
DW to an amazing DH since 2008
Divide it up. Turn some into chicken and broccoli alfredo, and put diced tomatoes and pieces of steak in the other one. Very yummy, even better if you add spinach but I know not many people like spinach. You might even be able to use them in soup. It might make the soup a little cheesy but is that really a bad thing? I am thinking a soup with beans, spinach, diced tomatoes, maybe some broccoli, and some chicken boullion, then the noodles.
Momma to DS (4) and DD (2)
Becoming Debt Free $12375-$0 in 1 year?
I can't drink all this by myself. I mean, I can, but then someone is getting naked.
Here in Denmark they eat spaghetti on pizza baked with the cheese on top. I love alfredo pizza in the US (but it is without the noodles, just the sauce and cheese... yum!) You might try that. I am afraid I haven't tried the spaghetti pizza myself, so I can't say how it would turn out.
Heidi- Suddenly single mommy to Elizabeth 19, identical twins William & Oliver 03/14/10, Theodor 4/25/11, (.Y.) GOLD BOOBIES! 6 sweet angels
Add some shrimp or chicken, maybe some broccoli and invite some friends or your husbands side of the family over to help eat it, maybe take some to an elderly shut in, or a family that just had a baby, or drop it off to the homeless shelter. Now that it is getting colder out those are starting to fill up. If I went the homeless shelter route, I would call first to make sure you could do that. Speaking of pizza, I just had a chicken alfredo pizza. It was on a self rising crust and pretty tasty.
Squeezed a lifetime of love into 1 hour with Tyler on 11/26/09 (CTT with BRA, Potter's Syndrome)
Keira Brielle arrived March '11
Add shrimp and broccoli and a little red pepper flakes.
Deb, mom to: a Princess, a Prince, a Princess, & a tail-wagger
You never know how STRONG you are until being STRONG is the only choice you have.


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Friday Flicks: Fedor Emelianenko MMA Highlight
Welcome to the Friday Flicks! Every Friday we kick off your weekend with a fun, fitness-related video you've never seen before. If you've missed previous weeks, you can catch up on them HERE!
This week - the legendary MMA fighter Fedor Emelianenko. Those of you new to the world of MMA might not be as familiar with the fighters who grew the sport. One of the most impressive amongst them is the Russian fighter known simply as Fedor. For years he dominated, and for good reason. This highlight reel will educate the newer fans and give the veteran fans some fights to reminisce over.
Topic: Friday Flicks
See more about: MMA, mixed martial arts, martial arts, fighting
Breaking Muscle is team of experienced professionals dedicated to providing comprehensive strength and conditioning, and mind/body wellness programs. We draw from our education, experience, and empirical research within our community to provide full scale services to athletes, coaches and consumers. Breaking Muscle specializes in Olympic lifting, powerlifting, functional fitness, yoga, and mind/body modalities. Breaking Muscle utilizes the latest research, products, and equipment to provide... Read More


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Kevin Bizier Declines Alexander IBF Mandatory Shot
Devon Alexander was scheduled to face his mandatory challenger, Kell Brook, of England, May 18 in Atlantic City on Showtime, but Brook was injured during training and had to withdraw. To ensure Kevin Bizier's presence in Atlantic City to fight Alexander, Golden Boy CEO Richard Schaefer also contacted the president of GYM, Yvon Michel, offering a very attractive proposition.
All members of Team Bizier - Kevin, Michel, Marc Ramsay, and Remi Bizier -- met yesterday to analyze the entire situation.The unanimous conclusion of this meeting was to refuse the IBF and Golden Boy's proposal. The current circumstances do not allow Kevin Bizier sufficient training and preparation required to participate in a fight of this magnitude against the established IBF champion. A letter was also sent this morning to the Chairman of the IBF Championships Committee, Mr. Lindsey Tucker, for this purpose.
"We believe that Kevin Bizier has the talent to become World welterweight champion this year," Michel said. "We thank the IBF and Golden Boy for the opportunity offered but, unfortunately, we had to decline because Kevin would not have been able to offer a performance, given the current context, at the height of his talent. This is only a postponement."
Meanwhile, Bizier is currently ranked No. 3 by the IBF and No. 6 by the World Boxing Association (WBA). He is still developing and expected to rise even higher in world rankings. His next fight will take place May 25, as planned, on the Pascal vs. Bute super event in Montreal.
Props to Lee Purdy for taking the fight. Even he said that you never know if you'll ever get a world title shot so you have to take one if it comes.Comment by elgranluchadore on 04-19-2013
i dont blame him, he would get robbed like kotelnyk or matthyseComment by Big Lou on 04-19-2013
Why is he rated #3 if doesn't want to fight for the title ?Comment by Tonyu on 04-19-2013
Wow what a decision by Bizier offered a World Ttile shot and turned it down - he is fighting on May 25 so I presume in training at the moment and offerd a fight on May 18 to fight Alexander…Comment by ShoulderRoll on 04-18-2013
If he lost to Alexander then so what? The experience he gains from that defeat will do more for him than wins against soft opposition.Post a Comment - View More User Comments (19)


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Here are some of the memorable images as the music industry celebrated its big night at the Billboard Music Awards.
Follow AP photographers and photo editors on Twitter: http://apne.ws/15Oo6jo
Welcome to your discussion forum: Click the login link below to sign in with or to set up a Disqus account or to access your social networking account. When you do, your comment should be posted immediately, provided it meets the guidelines. (What are the guidelines?.) Report abuse by flagging a comment (mouse over the comment). Comments made here are the sole responsibility of the person posting them; these comments do not reflect the opinion of The Berkshire Eagle. So keep it civil.
( Jordan Strauss )
Britney Spears mad about Lifetime biopic
Britney Spears insists she's not cooperating with a Lifetime made-for-TV movie that promises to revisit all the ups and downs of her tumultuous professional and personal story.


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Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s10162-009-0204-9
- Cite this article as:
- Fernandez, E.A., Ohlemiller, K.K., Gagnon, P.M. et al. JARO (2010) 11: 235. doi:10.1007/s10162-009-0204-9
- Citations
- 308 Views
Animal studies indicate that a combination of kanamycin (KM) and noise produces a synergistic effect, whereby the threshold shift from the combination is greater than the sum of the shifts caused by either agent alone. Most such studies have focused on adult animals, and it has remained unclear whether younger, presumably more susceptible, animals show an even greater synergistic effect. The present study tested the hypothesis that young CBA/J mice receiving a low dose of KM (300 mg/kg, 2×/day, s.c.) from 20 to 30 days post-gestational age followed by brief noise exposure (110 dB SPL; 4–45 kHz, 30 s) would show greater noise-induced permanent threshold shifts (NIPTS) than mice receiving either treatment alone. Noise exposure produced 30–40 dB of NIPTS and moderate hair cell loss in young saline-treated mice. KM alone at this dose had no effect on thresholds. Surprisingly, mice receiving KM plus noise were protected from NIPTS, showing ABR thresholds not significantly different from unexposed controls. Mice receiving KM prior to noise exposure also showed significantly less outer hair cell loss than saline-treated mice. Additional experiments indicated protection by KM when the noise was applied either 24 or 48 h after the last KM injection. Our results demonstrate a powerful protective effect of sub-chronic low-dose kanamycin against NIPTS in young CBA/J mice. Repeated kanamycin exposure may establish a preconditioned protective state, the molecular bases of which remain to be determined.
Keywordsototoxicitypreconditioningaminoglycosidescochleahair cellsdevelopment
The estimated incidence of clinically significant bilateral hearing loss in infants has been estimated at one per 500 live births (Mehl and Thomson 1998). Events that occur in the early days of life, including exposure to ototoxic antibiotics and/or noise, may result in an acquired hearing loss that is labeled congenital. Medically fragile neonates often receive antibiotics and may experience noise peaks of up to 125 dB SPL during emergency transport via aircraft (Skeoch et al. 2005; Shenai 1977; Buckland et al. 2003). This practice has remained, even though human neonates may be particularly susceptible to noise, ototoxins, and their combination (Henley and Rybak 1995; Bernard 1981; Li and Steyger 2009). Presently, the risk of noise-induced permanent threshold shifts (NIPTS) to human infants is largely uncharacterized.
An early window of heightened vulnerability to both noise and a wide variety of ototoxicants is well supported by animal studies (e.g., Pujol 1992; Bombard et al. 2005; Bernard 1981; Lataye et al. 2004; Rybak et al. 1991; Henley and Rybak 1995; Pryor et al. 1984). Cochlear targets most affected during this window include hair cells, neurons, and stria vascularis. Thus, no special susceptibility of any single structure or cell type can provide a complete explanation. Animal studies also support synergistic interaction between noise and ototoxins, at least in adults (e.g., Dayal et al. 1971; Dayal and Barek 1975; Marques et al. 1975; Hawkins et al. 1975; Ryan and Bone 1978; Brown et al. 1980; Brummett et al. 1992). Most of these applied high levels of noise and ototoxins. However, Brummett et al. (1992) identified a synergistic effect between subclinical doses of white noise (as low as 75 dBA) and kanamycin (300 mg/kg) on hair cell loss in adult guinea pigs. It has remained unclear to date whether such synergy extends to neonates or is perhaps even more pronounced in neonates (Humes 1984; Henley and Rybak 1995; Li and Steyger 2009).
Here, we explore the interaction of sub-chronic, low-dose kanamycin (KM) and damaging noise using young (post-wean) CBA/J inbred mice as a model. The laboratory mouse is a well-established model for human auditory conditions, as it possesses similar cochlear anatomy and physiology and similar patterns of age-related, noise-induced, and ototoxicity-related hearing loss (Ohlemiller 2006; Wang and Steyger 2009; Wu et al. 2001; Henry and McGinn 1992). Among inbred strains, CBA/J mice are frequently used as a "good hearing" strain that is resistant to age-associated pathology. Like other animals and humans, young mice are especially susceptible to NIPTS (Henry 1983; Ohlemiller et al. 2000). Noise vulnerability in mice appears greatest during the first month then gradually decreases up to about 4 months of age (Henry 1983). Young mice also show greater susceptibility to ototoxins (Henry et al. 1981; Chen and Aberdeen 1980; Chen and Saunders 1983). Similar to the pattern for noise, vulnerability to aminoglycosides in mice appears maximal during the first month. After 1 month, it can be difficult to elicit ototoxic injury in mice without co-administration of ethacrynic acid or furosemide (Wu et al. 2001; Taylor et al. 2008). In keeping with the literature, we hypothesized that young mice would show stronger KM plus noise synergistic effects on hearing than have been reported in adult animals. As we show, the nature of the interaction was surprisingly one of prevention of NIPTS, not potentiation.
Average ABR thresholds by experimental group at each test frequency
5 kHz
10 kHz
20 kHz
28.3 kHz
40 kHz
No treatment
41.44 (4.64)
23.56 (4.64)
31.67 (7.91)
32.11 (6.51)
38.33 (8.29)
Noise alone
68.11 (18.67)
58.56 (20.07)
64.44 (24.30)
73.78 (27.05)
90.00 (22.91)
KM alone ABR 10 days post noise
39.22 (3.63)
22.44 (1.67)
25.56 (3.00)
31.00 (5.00)
36.25 (9.71)
KM alone ABR same day
40.13 (5.30)
24.88 (2.59)
31.63 (6.78)
32.50 (4.63)
40.63 (4.17)
KM + Noise
42.63 (6.23)
22.38 (4.17)
30.63 (4.96)
34.13 (4.58)
53.13 (19.45)
Saline + Noise
67.00 (15.28)
63.71 (17.42)
66.00 (18.25)
75.71 (7.32)
82.86 (6.36)
1 dose KM + Noise
68.11 (17.81)
57.44 (21.28)
69.00 (15.90)
80.89 (6.62)
93.33 (8.29)
Kanamycin injections
Mice receiving kanamycin sub-chronically were injected subcutaneously twice daily at 300 mg/kg for 11 days (63.93 mg/ml KM in 0.9% saline). Injections began at 20 days post-gestational age (PGA) and ended at 30 days PGA. Mice were weighed prior to each injection. Injections occurred at 12-h intervals. The drug regimen was well-tolerated, and no mice were lost during the course of treatment. Mice in the saline treatment group received an equivalent volume of saline using the same injection regimen.
Noise exposure
At 30 days PGA, mice were exposed to 30 s of broadband noise (4 to 45 kHz) at 110 dB SPL. Noise was produced and filtered with General Radio 1310 generators and Krohn-Hite 3550 filters, respectively. Groups of two or three animals were placed in a wired cage suspended between four speakers at 0°, 90°, 180°, and 270° azimuth in a single-walled soundproof booth with foam treatment (Industrial Acoustics, Bronx, NY). The cage was rotated at approximately 0.013 Hz during the exposure to achieve a homogeneous sound field. For all noise groups except the group receiving a single KM dose, the noise exposure was initiated 15 min following the final dose of kanamycin or saline. This interval was based on previous pharmacokinetic analyses of subcutaneous kanamycin injections in mice showing peak serum levels at approximately 15 min post-injection and an elimination half-life of 1 h (Wu et al. 2001).
ABR recording
Because of the fragility of post-weaning mice at the time of initial treatment, our study design called for a single ABR recording in each animal following all other procedures. Thus, ABR thresholds, not threshold shifts, were compared by treatment group. For most groups, ABR recording was carried out 9–11 days post-treatment (39–41 days PGA) using Tucker–Davis Technologies (TDT) System II hardware and software. Animals were anesthetized with a solution of ketamine and xylazine (80/15 mg/kg, i.p.) and positioned dorsally in a custom headholder. Subdermal platinum needle electrodes (Grass) were placed in the mid-back (ground), behind the right pinna (active), and at the vertex (reference). Body temperature was monitored throughout testing using a rectal probe and maintained at 37.5 ± 1.0°C using a DC current-based isothermal pad (FHC). The right ear of each mouse was stimulated in freefield using a TDT ES-1 speaker placed placed at 7 cm distance along the interaural axis. Stimuli were 5 ms tonebursts (1,000 repetitions, 20/s, 1.0 ms rise/fall time) at frequencies of 5, 10, 20, 28.3, and 40 kHz. To eliminate contributions to the ABR by the unstimulated ear, the left external meatus was compressed using a spring-loaded clip. Responses were amplified ×100,000 and filtered at 100–10,000 Hz. Wave I of the ABR is considered to be generated by auditory nerve activity and is the most robust wave of the mouse ABR (Zheng et al. 1999). Thresholds were taken to be the lowest sound level for which Wave I could be identified, using a 5-dB minimum step size. Threshold differences by group were analyzed by two-way ANOVA (threshold by treatment, frequency) followed by Bonferroni multiple comparisons tests.
Tissue preparation and analysis
Cochleas of mice from two experimental groups, KM + Noise and Saline + Noise (N = 7 each), were prepared for histological analysis after recording. Animals were overdosed using Pentobarbital and perfused transcardially with cold 2.0% paraformaldehyde/2.0% glutaraldehyde in 0.1 M phosphate buffer (pH 7.4). Each cochlea was rapidly isolated and immersed in the same fixative, and the stapes was removed. Complete infiltration of the cochlea by fixative was facilitated by drilling a small hole at the apex of the cochlear capsule and gently circulating the fixative over the cochlea using a transfer pipet. After decalcification in sodium EDTA for 72 h, cochleas were post-fixed in buffered 1% osmium tetroxide, dehydrated in an ascending acetone series, and embedded in Epon.
Qualitative light microscopy
Left cochleas were sectioned in the mid-modiolar plane at 4.0 µm then stained with toluidine blue for bright field viewing with a Nikon Optiphot™ light microscope using a ×100 oil objective and a calibrated grid ocular. Typically 50 sections were obtained from each cochlea, spanning 200 µm centered on the modiolar "core."
Hair cell counts
Right cochleas were dissected using fine blades into half-turn segments, immersed in mineral oil in a depression slide, and examined as surface preparations by Nomarski optics using a ×20 oil objective and a calibrated grid ocular. The percent outer hair cells (OHCs) and inner hair cells (IHCs) missing (as judged by the absence of nuclei) was estimated in contiguous 200 µm segments, and data were recorded separately by cell type as a function of distance from the basal tip. For each hair cell type, distance versus percent present was plotted as a function of frequency based on Muller et al. (2005). Hair cell survival differences by group were analyzed by two-way ANOVA (cell loss by treatment, cochlear place), followed by Bonferroni multiple comparison tests.
ABR thresholds
Histologic findings
The finding of normal thresholds in mice receiving KM alone (Fig. 2) indicated that the KM dose applied was sub-toxic. Nevertheless, since the cochlear base is most vulnerable to ototoxins, we considered whether the modest hair cell loss in the cochlear hook region of KM-treated mice might be due to KM, and not noise. Examination of three cochleas from mice receiving KM without noise (not shown) revealed partial loss of OHCs spanning much of the hook region in one animal. Such loss is atypical of young CBA/J mice. Notably, however, two of seven mice receiving both KM and noise showed no hair cell loss. Combined with threshold data (Figs. 1 and 2), the evidence suggests that hair cell loss in the basal tip of some KM + Noise animals may have been caused by KM itself, but more often probably represented residual noise injury.
Summary of findings
No synergistic effect increasing NIPTS was found for mice treated with both kanamycin and noise. Instead, mice treated with a sub-chronic, low dose of kanamycin prior to noise exposure were paradoxically protected from NIPTS, showing ABR thresholds not significantly different from unexposed controls. The protected mice correspondingly showed significant preservation of OHCs in the basal half of the cochlea compared to saline controls. Kanamycin alone had no effect on ABR thresholds immediately following treatment (that is, at the time noise exposure occurred) or at the termination of experiments (Fig. 2). These findings argue against an acute hearing loss at the time of noise exposure, which could have potentially provided a degree protection against NIPTS. They also argue against any permanent effect of the KM treatment on thresholds, although we could not rule out that some hair cell loss in the extreme base was KM-related. A single dose of KM prior to noise was not protective; thus, the mere presence of kanamycin at the time of noise exposure was not sufficient to provide protection (Fig. 3). This result argues against any protective mechanisms that require only the presence of KM, such as plugging of transducer channels (Marcotti et al. 2005), thereby reducing active force generation by OHCs. Animals in the Saline + Noise group were not protected from NIPTS (Fig. 4). Therefore, protection afforded by the stress of handling and injection, potentially mediated by glucocorticoids (Wang and Liberman- did not appear to be a significant factor. Additional experiments in which the interval between the final KM dose and noise exposure was extended further indicated that KM's protective effects continue at least 48 h from the end of the dosing regimen. A corollary of the latter observation is that less rigorous dosing paradigms than the one we tested may be equally effective against similar exposures.
Noise vulnerability in CBA/J
Our original hypothesis called for an experimental paradigm involving subclinical levels of both noise and KM. While the chosen KM regimen appeared subclinical in most cases, exposure to 30 s of noise produced moderate NIPTS and hair cell loss in the young CBA/J mice. This was not an anticipated outcome, although it produced the benefit of a large NIPTS that uncovered KM-related protection. Previous research comparing the noise susceptibility of mice (CBA/CaJ, C57BL/6J, BALB/cJ) aged 1–2 and 5–7 months (Ohlemiller et al. 2000) determined NIPTS "threshold" for exposure duration of 3.4 min for young CBA/CaJ mice using the same noise applied here. Based on this result, it was presumed that young CBA/Js would show a noise dose-response pattern similar to the CBA/CaJ and that 30 s of noise would produce no NIPTS. CBA/CaJ and CBA/J mice are often treated as interchangeable for purposes of hearing studies. The present noise work, along with a recent comparison of aging CBA/J and CBA/CaJ (Ohlemiller 2009), suggests this is not the case. The surprising noise vulnerability of young CBA/J, which we describe elsewhere (Rybak Rice et al. 2009), contrasts with a lack of any notable susceptibility to kanamycin (Wu et al. 2001). The extent of NIPTS and hair cell loss in the young CBA/Js strongly suggest our KM results are not limited to an "unchallenging" noise or to noise that only causes a temporary threshold shift. In fact, the extent of both NIPTS and hair cell loss in these mice exceeded those produced by 2 h of similar noise in older CBA/J mice (Ohlemiller and Gagnon 2007). It is possible that the present results are closely tied to some unusual characteristic of young CBA/Js.
Cells impacted by noise and protected by KM
The only clear anatomic difference that distinguished the KM-protected mice from saline controls was the extent of OHC loss (Fig. 7). Both groups of mice showed inner and outer hair cell loss in the cochlear hook, a region not monitored by our highest ABR stimulus frequency (40 kHz). OHC loss in KM-treated mice also extended into the lower base so that essentially all NIPTS in these mice could be accounted for in terms of hair cell loss. Within saline controls, OHC loss extended apically to regions serving the three highest ABR test frequencies (20, 28.3, 40 kHz). The most parsimonious explanation for NIPTS in these mice was, therefore, OHC loss in the lower base and subtle OHC injury more apically. Within the cochlea, aminoglycosides preferentially injure the stria vascularis and outer hair cells (Taylor et al. 2008; Rizzi and Hirose 2007; Forge and Schacht 2000). Although noise can also injure the stria, the injury appears largely reversible under all but the most extreme conditions (Ohlemiller and Gagnon 2007; Hirose and Liberman 2003), and it is not clear that lateral wall events can ultimately impact the extent of NIPTS (Ohlemiller 2008). Since OHC function and survival represent the most salient common target of both noise and KM, we suggest that preservation of OHC function and survival constitutes the most likely locus of KM-related protective mechanisms and that KM engages protective cascades within OHCs. Recent studies in young mice (Wu et al. 2001; Wang and Steyger 2009) indicate that significant levels of KM would have been present in both cochlear fluids and hair cells at the time of our noise exposure. Aminoglycosides may enter hair cells from either endolymph or perilymph and may require 24 h to be cleared (Wang and Steyger 2009; Li and Steyger 2009). Thus, significant levels of KM were likely maintained and probably increased over the course of treatment. Even a single KM dose, which we found not to be protective (Fig. 3), should have yielded "therapeutic" levels within the organ of Corti 1 h later. The lack of efficacy in this case argues for an innate protective response to KM that activates with some delay. Whether any single dose paradigm may be protective is under study.
Sub-chronic kanamycin as a form of preconditioning
Sub-chronic low-dose application of kanamycin likely engages innate protective mechanisms and thus may be added to the ranks of preconditiong stressors. Preconditioning refers to a mildly injurious event that confers protection against a later, more injurious, event (Gidday 2006; Dirnagl et al. 2003; Eisen et al. 2004; Ran et al. 2005). Demonstrated preconditioning inducers against NIPTS in mice include mild noise, heat stress, restraint, and hypoxia (Yoshida et al. 1999; Wang and Liberman 2002; Yoshida and Liberman 2000; Niu and Canlon 2002; Gagnon et al. 2007). Two studies have reported partial protection in guinea pigs by amikacin or gentamicin against later, high-dose, application of the same ototoxins (De Oliveira et al. 2004; Maudonnet et al. 2008). Many pathways and processes have been implicated in preconditioning, including improved blood flow, increased glucocorticoid levels, enhanced antioxidant protections, and increased production of heat shock proteins. Those that participate in the protection demonstrated here remain to be determined. KM affects multiple organs (Henley and Rybak 1995; Rizzi and Hirose 2007; Forge and Schacht 2000), where it may also elicit protective cascades, so that systemically mediated preconditioning influences cannot presently be ruled out.
The principles of preconditioning link a sub-injurious event to protection against a later injurious event. Very likely, there exists a tradeoff between the severity of the initial event and the extent of later protection. Our effective KM dose may have caused some OHC loss and thus may not have been sub-toxic in every case. While we have not yet probed the limits of the protection against NIPTS afforded by KM, it is possible that KM-related injury and protection are causally related. It may, for example, be possible to find circumstances and models in which increasing protection against NIPTS at mid and low frequencies is positively linked to elevated thresholds and hair cell loss in the deep cochlear base.
Kanamycin in the early vulnerability window
An early window of heightened vulnerability has been found in animals to apply to noise injury as well as a variety of ototoxins. The targets of this early magnified injury show only partial overlap: Ototoxins primarily impact hair cells and stria (Bernard 1981; Lataye et al. 2004; Pryor et al. 1984; Rybak et al. 1991; Henley and Rybak 1995), while noise preferentially targets hair cells and neurons (Henley and Rybak 1995; Falk et al. 1974; Ohlemiller et al. 2000; Kujawa and Liberman 2006). The window of vulnerability also need not be the same for noise versus aminoglycosides (Henry et al. 1981; Henry 1983) or even for all ototoxicants (e.g., Lataye et al. 2004). The existence of somewhat different targets and timeframes for noise and ototoxic injury suggests that these operate at least partially independently. We know of no other study demonstrating a protective effect of kanamycin or any other ototoxin against NIPTS. Instead, many studies have shown exacerbation of NIPTS by aminoglycosides in animals (e.g., Bombard et al. 2005; Dayal et al. 1971; Dayal and Barek 1975; Marques et al. 1975; Hawkins et al. 1975; Ryan and Bone 1978; Brown et al. 1980; Brummett et al. 1992). This effect has, therefore, been predicted for humans and anticipated to be enhanced in human infants (see Li and Steyger 2009). The prediction of amplified synergistic interactions early in life has found some support in animal studies (Dodson et al. 1982) but, to date, no direct support in humans (see citations in Li and Steyger 2009). The robustness of the protection we find in young CBA/J mice may mean that at least for low KM doses, the true nature of KM/noise interactions during the early window is just the opposite of predicted outcomes. A general protective effect might reflect distinct characteristics of protective cascades early in life and may even be causally related to the very factor(s) that underlie the early vulnerability window.
The present findings may hold implications for which treatments in medically fragile human neonates pose extra risks and which do not. Once uncovered, the protective pathways that kanamycin engages may offer new pharmacologic interventions, both during the early vulnerability window and later. Should our findings ultimately prove limited to particular mouse models, it should be possible using standard genetic approaches to identify critical genes and pathways. These genes may provide insights into the nature of injury and innate protection during the early window and could lead to genetic tests for individual risk.
Thanks to M. Rybak Rice and A. Rosen for technical assistance and to Dr. K. Hirose for critical comments; supported by P30 DC004665 (R. Chole), P30 NS057105 (D. Holtzman), R01 DC03454 (KKO), R01 DC08321 (KKO), WUSM Department of Otolaryngology.


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Home > Indexes > Avue Inc. > AV762SDIR
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- Report: #171839
Report - Rebuttal - Arbitrate
Complaint Review: Berman Investment Group
Berman Investment Group2967 Mickelson Drive Suite G Irvin, California U.S.A.
The Berman Investment Group, fraud fraudulant billing unscrupulous dishonest ripoff Irvin California
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I read the pages carefully and filled out my contect information. I click the button to continue and came to a page listing a reciept showing what I was getting and that there was no cost for the item, there was the term FREE listed at least 5 times on the page, 4 times inside the reciept. I filled out my credit card information and selected the button to continue.
I received the material and was charged accordingly. A month later they charged my account again but this time it was $100. I contacted the company and questioned the charge. I stated to the representative that I never agreed to the charge and I would like it to be removed. He would not and said that I had 30 days to cancel bbut that 30 days had lapsed. He stated that it was on the site that I ordered from.
I went to the site and started reading through again. I found no terms or agreements up to the point that I continued after entering my credit card information. I did find though that if I read the small print at the bottom of the page that there was a notice that I would be charged if I did not cancel in 30 days.
I disagree with this mechanism of fraud as I never agreed to that "agreement", as there was nothing notifying of an agreement and the agreement was after my "signature" (submit button) which I understand to be an agreement for everything prior to the signature.
I contected the comapny and requested that I be refunded my money but the best offer they gave would be to refund everything minus $15. That they would refund $85 of the $100 dollars charged. As I was unssure of what my credit card comapny would do (this was they first time with dealing with a fraudulant charge) I said yes.
After the call I felt that even though the difference was $15 that they were acting fraudalantly in the initial charge and not providing a complete refund.
I contacted my credit card company and requested their help in resolving the matter. I relayed to them the whole situation as listed above. They took the steps over a few weeks to resolve the matter with the knowledge that this charge was made without my consent. The adjusted my balance and almost a month later, BIG, adjusted my balance again with the $85 refund which was again reversed as my credit card company had corrected the problem initially.
From my initial charge (legal) to the unauthorized charge, and to completing the steps needed to correct charges to my credit card took almost 3 months. I continue to see the offer on TV and the website changes on a more than infrequent to almost a frequent basis. During this time I actually found Ripoff Report.com when I was searching for additional information in regards to this company after they charged my credit card. There was another person whose report was almost identical accept he may have received a set of CDs after being charged which I did not and am glad that they were not sent.
Watch out for this company and dealing with them.
Warriors Mark, Pennsylvania
This report was posted on Ripoff Report on 01/15/2006 06:52 AM and is a permanent record located here: http://www.ripoffreport.com/r/Berman-Investment-Group/Irvin-California-92612/The-Berman-Investment-Group-fraud-fraudulant-billing-unscrupulous-dishonest-ripoff-Irvin-171839. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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In America; Meet Mayor Manners
By BOB HERBERT
Published: March 5, 1998
Politicians by definition are hypocritical, some more than others. But hypocrisy soars to astonishing new heights when Rudolph Giuliani, the snarling, bullying, hot-tempered Mayor of New York, starts lecturing people on the need to be more civil, more polite, more considerate of one another.
This is Willie Sutton lecturing us on the importance of personal savings -- chutzpah at its breathtaking best.
''Does everybody remember Plato?'' the Mayor asked. ''Plato developed the notion of the ideal. You never reached it. But in striving to get there, you kept making improvements in society.''
Pretty words from a Mayor who is carefully crafting a personality makeover as he shops around for a higher office. Forget Plato for a moment. Does anyone remember the original Rudy Giuliani?
''Bull----!'' he screamed again and again as he stood on a platform in September 1992 and vulgarly displayed his solidarity with a rowdy, beer-swilling crowd of 10,000 cops who spewed racial invective and illegally tied up traffic during a wild demonstration outside City Hall.
Does anyone remember that this is the Mayor who publicly humiliated and then chased out of office two men who were doing an excellent job for the city -- Schools Chancellor Ramon Cortines and Police Commissioner William Bratton? Mr. Giuliani, jealous of Mr. Bratton's high profile and popularity, has nevertheless been coasting on the former Commissioner's public safety accomplishments ever since.
The Mayor tried to replace Mr. Cortines, also widely popular, with a nonentity named Leon Goldstein. There were some problems. Mr. Goldstein slipped into a mini-trance when a reporter asked how old he was, and he seemed frankly discombobulated when confronted with tough questions like how long he had been married. When concerns about patronage and possible conflicts of interest arose, Mr. Goldstein withdrew his candidacy.
Former Mayor Edward Koch, a Giuliani supporter and a man capable of playing a pretty brutal game of political hardball himself, said of Mr. Giuliani: ''The Mayor's willingness to bear false witness, his mean-spiritedness and bully tactics are major character flaws.'' He described Mr. Giuliani as ''a good administrator,'' but added, ''He is not a decent human being.''
Other politicians, both Democrats and Republicans, say much the same thing in private. Mr. Giuliani is widely seen as tyrannical, vindictive and often cruel. Bureaucrats are terrified of him. The men and women who run nonprofit agencies that depend on city funding are reluctant, while on the record, to offer even the mild est criticism of the Mayor.
Last week Mr. Giuliani withdrew all city funding from an asthma education and treatment initiative in the Bronx that is to be run by the Children's Health Fund, a national model in the delivery of health care to poor youngsters. The head of the program is Dr. Irwin Redlener, a very mild-mannered and dedicated physician. Dr. Redlener had the temerity to complain about the heavy-handed way in which the city was negotiating with the fund. That, he learned, was a mistake. The loss to the program and the kids it will serve: $1.5 million a year.
Yesterday a charming picture of Mr. Giuliani was on the front page of The Daily News. A Dr. Seuss hat had been superimposed on the Mayor's head and he was reading to a group of children. The story was about a children's book the Mayor is writing in his spare time. The working title is, ''What Will You Be?''
This is just the sort of thing -- the discussion of public school uniforms is another -- that can deflect attention from the Mayor's miserable education record. Mr. Giuliani cut $1.2 billion from the school budget in his first two years in office and did not even make a pass at a budget enhancement until last year when he was running for re-election and all the polls were saying that education was the top issue. Writing a book won't hide the fact that the school system has suffered terribly under Rudolph Giuliani and continues to suffer.
New Yorkers get a bad rap. Most are far more polite, far more considerate and far more concerned about the plight of the city's children than Hizzoner. If Mr. Giuliani wants to lecture somebody, he should do it where it's most needed -- in front of a mirror.


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A project of People For the American Way dedicated to monitoring and exposing the activities of the right-wing movement. Learn More >
Brown: "Hypersensitive" Gays Want To Put Christians Into Jail
Cindy and Mike Jacobs host a weekly television program called "God Knows" where they discuss current events, like how abortion curses the land and how such sins then causes natural disasters.
On the last two episodes, the guest has been anti-gay activist Michael Brown, author of "A Queer Thing Happened to America" who explained that the ultimate agenda of gay activists is to put Christians into jail:
Mike Jacobs: So what is their ultimate goal, Michael? Do they have an agenda that they're marching down a path with?
Brown: There are absolutely gay activist organizations with tens of millions of dollars of funding, left and right, corporate America backing them as sweethearts. Even out president supporting them ...
Cindy Jacobs: Oh huge, celebrating in the White House ...
Brown: With an absolute agenda. The agenda is the complete normalization of homosexuality and the complete removal of any opposition to it whatsoever.
Cindy Jacobs: And that's us.
Brown: Here it is in a nutshell: the activists who came out of the closet about forty years ago first said "we demand our rights." Then they began to point to others and said "you have to accept our rights." Then they began to point to conservatives, especially conservative Christians, and said "we're taking away your rights." And next thing, they want to put us in the closet.
Cindy Jacobs: Or in jail.
Brown: Or in jail. In fact an attorney friend of mine said "cycle it once more: it's not just they came out of the closet and want to put us in the closet; they were put in jail, they want to put us in jail."
When Mike Jacobs asked why this topic is such an intense issue that creates such heated reactions, Brown asserted that it was because gays are "hypersensitive" because they know are not "affirmed by God":
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A weekly meme hosted by Breaking the Spine.
Title: Nil
Author: Lynne Matson
Publisher: Henry Holt
Genre: Young Adult | Dystopian
On the mysterious island of Nil, the rules are set. You have one year. Exactly 365 days–to escape, or you die.
Seventeen-year-old Charley doesn't know the rules. She doesn't even know where she is. The last thing she remembers is blacking out, and when she wakes up, she's lying naked in an empty rock field.
Lost and alone, Charley finds no sign of other people until she meets Thad, the gorgeous leader of a clan of teenage refugees. Soon Charley learns that leaving the island is harder than she thought . . . and so is falling in love. With Thad's time running out, Charley realizes that to save their future, Charley must first save him. And on an island rife with dangers, their greatest threat is time.
I'm really excited to read this one. I love dystopians and survival books and I think this will be a nice combination of both. I also love that it takes place on a tropical island, I haven't read many dystopians with that type of setting. Can't wait to read this!
What are you waiting on?


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Guide Picks: The top holiday light displays in D-FW
Photo: Alexandra Olivia/Special Contributor
PRAIRIE LIGHTS -- More than 4 million lights twinkle in this drive-through holiday attraction. You can also hop out at the Holiday Village and see a walk-through area, visit with Santa and check out a light show. Continues through Dec. 31 at Lynn Creek Park, 5700 Lake Ridge Parkway, Grand Prairie. prairielights.org.
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- Report: #280889
Report - Rebuttal - Arbitrate
Complaint Review: Brake Masters Kingman Az
Brake Masters Kingman Az3400 Stockton Hill Rd Kingman, Arizona U.S.A.
Brake Masters This company allows a sex offender to work with the public Kingman Arizona
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A level 2 sex offender no matter what should never be around children. Imagine what he does to his own family. He has been asked to not live in certain communites due to his staus.
How can a church allow him to be around young girls. It is sick. We are leaving this city due to this, it makes my skin and along with 200 people that know but cannot afford to move.
Thank you for your time,
Kingman, Arizona
This report was posted on Ripoff Report on 10/25/2007 12:54 PM and is a permanent record located here: http://www.ripoffreport.com/r/Brake-Masters-Kingman-Az/Kingman-Arizona-86401/Brake-Masters-This-company-allows-a-sex-offender-to-work-with-the-public-Kingman-Arizona-280889. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Celtics Renounce Rights To 2013 Draft Pick Colton IversonIt's hard to find a team in the NBA right now that has a bigger logjam of young players than the Boston Celtics.
Why Did Celtics Draft Pick Abdel Nader Agree To Sign In D-League?Abdel Nader, Boston's No. 58 overall pick, has agreed to sign with the Maine Red Claws, Boston's D-League affiliate for the 2016-17 season.
Celtics' Abdel Nader Picks D-League Over Big Payday In EuropeInstead of taking a big payday overseas, Abdel Nader is going to chase his NBA dream in the D-League.
Robb: Do Celtics Really Have Easiest Schedule In NBA?Brian Robb takes his annual look at the Celtics' regular season schedule to determine whether it is in fact the easiest schedule in the league, as ESPN projects.
Celtics Sign Marcus Georges-Hunt To Training Camp DealThe Celtics added one more name to their already crowded roster this week by agreeing to terms with undrafted guard Marcus Georges-Hunt to a training camp deal.
Breaking Down Celtics' 2016-17 ScheduleA closer look at the Celtics' upcoming season, which includes a lot of exposure on national TV.
Celtics Will Reportedly Play Knicks On Christmas DayThe Boston Celtics have been able to enjoy Christmas Day with their families the last few years, but that will all reportedly change in the upcoming season.
Robb: Celtics Salary Cap OverviewBrian Robb takes a closer look at the Celtics' salary cap situation for next season and beyond.
Robb: Grading The Celtics OffseasonBrian Robb looks at the offseason moves to see how Danny Ainge fared upon trying to improve on last season's 48-win squad.
Ray Allen Says He's Talked Potential Comeback With CelticsFormer Celtics guard Ray Allen said he's considering a comeback at age 41 and would like to play for the team he won his first title with.
How Russell Westbrook's Extension With Thunder Impacts CelticsBrian Robb breaks down everything the Russell Westbrook extension means for the Boston Celtics.
What's Next For Boston Celtics?With Kevin Durant in Golden State and Russell Westbrook staying in Oklahoma City, what's next for the Boston Celtics? Masslive.com's Jay King joined Adam Jones to discuss their future.


text:
Kingsley, Mary Henrietta, 1862-1900
From Library of Congress Name Authority File
Kingsley, Mary Henrietta, 1862-1900
- [Mary Henrietta Kingsley (1862-1900) was an English ethnologist, explorer, author, and scholar.]
Instance Of
Scheme Membership(s)
Collection Membership(s)
Additional Information
Birth Date
- 18621013
Death Date
- 19000603
Birth Place
- London, England
Death Place
- Cape Town, South Africa
- female
Associated Language
- (itoamc) Ethnologist
- (itoamc) Author
- (itoamc) Explorer
Exact Matching Concepts from Other Schemes
- found: Travels in West Africa, 1997: t.p., etc. (Mary H. Kingsley; b. 1862 in London; a naturalist, ethnologist, sailor, scholar, and lecturer; she was commissioned to collect fish and reptiles for the British Museum, and in 1893, she traveled to the Congo, in 1895 she journeyed to Southern Nigeria; volunteered for nursing service during the Boer War; d. 06-03-1900)
- found: Wikipedia, via WWW, Oct. 10, 2012 (Mary Kingsley; Mary Henrietta Kingsley; b. October 13, 1862 in Islington, London, England; d. June 3, 1900 in Cape Town, South Africa; English ethnographic and scientific writer and explorer)
General Notes
[Mary Henrietta Kingsley (1862-1900) was an English ethnologist, explorer, author, and scholar.]
Change Notes
- 1983-06-20: new
- 2012-10-12: revised
Alternate Formats


text:
The mother of Lionel Tate's victim says the teen needs to accept responsibility for murdering her 6-year-old daughter.
Deweese Eunick-Paul said today that Tate's supporters are QUOTE
"making light" of her daughter Tiffany Eunick's death when they say the 1999 slaying was an accident.
Autopsy reports showed the girl was beaten to death, suffering a lacerated liver and at least 35 other injuries.
Tate was 12 when he killed Tiffany. He says he leapt from a staircase and accidentally landed on her chest.
The girl was at his Pembroke Park home, being baby-sat by his mother.
Tate turns 17 on January 30th. He is scheduled to appear in court Thursday to finalize an agreement he signed earlier this month that would see him plead guilty to second-degree murder. In the deal, Tate will be sentenced to three years in prison - most of which he has already served - plus one year of house arrest and 10 years probation. He could be released after a Monday bond hearing.
Eunick-Paul has agreed to the terms of the plea deal.


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All Posts In » Pop Culture
Why is Twitter so addicting?
Hi, my name is Trina. I am an addict, a twitter addict. I can't stop checking it. Lately, I leave my Twitter page open all day. At any point, I refresh and 15 new messages will show up. Do I really need to know what everyone is doing all day? No. Is it incredibly interesting? Yes! For those of you that have no idea what I am talking about, Twitter is a website where people basically leave im's about what they are doing. You can follow other users and be followed. To do a better job with the explanation, here is a video from the folks over at CommonCraft to explain Twitter in plain English: Tech blogger, Robert Scoble tackled the Twitter question today. Basically what is it that makes Twitter so addictive? According to him the secret is in following people and becoming a better listener. "So, that's myRead more →
Unknown Anime of the Week
I decided why not? I'd do a weekly survey of the not Narutos and Bleaches of the bunch. Truly good anime but when I converse about it in Anime club they all say "What?" The overlooked anime that is quite good and deserves a second look. I shall be going over these series (granted that they are licensed) and why it's a must see. So let's get started: This week's anime is Kono Minikuku mo Utsukushii Sekai- This Ugly Yet Beautiful World [img]http://i162.photobucket.com/albums/t278/vainya/A2836-6.jpg[/img] [b]Name of series:[/b] This Ugly Yet Beautiful World [b]Licensed by:[/b] ADV Studios [b]Broadcast on:[/b] Anime Network VOD [b]Genres:[/b] action, comedy, drama, romance, science fiction [b]Age rating:[/b] Teen (has some nudity and fantasy violence) [b]Number of episodes:[/b] 12 [b]Plot summary by anime news network:[/b] High school student Takeru Takemoto works part time as a (motor)bike courier. During one of his deliveries, he saw a mysterious light passing himRead more →
Viz Media secures Bleach license for movie release
You can't go to any anime convention without running into at least one Bleach cosplay. Most people only cosplay characters they love, so Bleach must be a property that people enjoy. Viz Media knows this and have secured the rights to release Bleach the Movie: Memories of Nobody. The movie will actually have a theatrical release in major cities throughout North America this summer. The DVD release will be available just in time for the holidays. "We are extremely excited to announce the domestic license for BLEACH THE MOVIE: MEMORIES OF NOBODY," says Liza Coppola, Sr. Vice President, VIZ Media. "BLEACH has emerged as one of the most popular animated, manga and video game properties in North America and the release of this film will no doubt captivate millions of avid fans. Filled with riveting animation and spectacular battle scenes featuring all the major characters, BLEACH THE MOVIE is ideallyRead more →
Angelic Pretty opens their English online shop!
Angelic Pretty is one of the top clothing companies that provide "Sweet Lolita" Style clothing. We haven't really gone over what Sweet Lolita is here yet, but here's a crash course from the Angelic Pretty website: Lolita Fashion is a fashion culture that was born in Japan. The characteristic is a princess-like silhouette such as lace, frills, and puffed sleeves. Angelic Pretty sells clothes where the concept is "cute" and "sweet". Everything is so very cute on the new Angelic Pretty English website. For the first time, people can now order straight from Angelic Pretty instead of going through a service (which is more expensive). AP only takes Paypal right now, and they also have a currency calculator on the site, so you can see how much the clothing will actually cost you. With the dollar being weak, it might actually be more than you want to spend. From experience,Read more →
No Country For Old Men
No Country For Old Men isn't a serial killer chase across Texas as the movie previews would have you believe. It's really a great tale about the good ole boys of Texas and how they don't really fit in with today's world. Of course this movie is set back in a time (you could try to guess) either seventies or early eighties. The movie stars Javier Bardem as a precise, cool-calculated killer for hire on a mission. Though at times the mission seems to take a back seat to his own "moral" code on living/killing. Also starring Tommy Lee Jones, Josh Brolin and guest appearance of Woody Harrelson. I have to say that I love Woody however his scene's in the film weren't pertinant to the story, a lot of the dialog just seemed like they were stretched for the actors benefit. As if the scene were only one sentenceRead more →By GamingAngel in Movies No comments yet
World's 50 most powerful blogs
The Guardian UK posted an article yesterday that lists the world's 50 most powerful blogs. What characterizes a powerful blog? The criteria seems to be hits, but even that is inconsistant. From reading through their top 50 choices, some are obvious and yet other blogs that I would think would make the list are completely vacant. Number one on the list is the Huffington Post, a political blog that started with money and name recognition from Arianna Huffington. The Guardian says like her or not, she gets traffic. Boing Boing makes it at number 2 on the list. Which makes sense. This blog is the new slashdot. Within minutes of posting something new, cool and unique the person's site goes down. You should definitely read the list to see if some of your favorite blogs made the cut. While Gawker made the list along with their sub-site Jezebel, Kotaku isRead more →By GamingAngel in Web Trends 1 Comment »
Tokidoki for Hello Kitty = too much cuteness!
Okay my Hello Kitty loving heart is so happy to hear about this. Tokidoki, who is much loved for her interesting anime style artwork, is releasing a line of Hello Kitty themed items. Currently the line is only available in Japan but will be coming to Tokidoki.com and www.sanrio.com soon. The line will consist of the necklace in the picture, purses, wallets and even statues. Go here to take a look at some of the items. The best thing about the line, not just that it combines great classic with a new artist, but it's actually pretty affordable. Unlike the Kimora Lee Simmons or Tarina Tarantino line, the necklace only costs $45. I ordered my necklace today and will take some pictures when it comes in! I can't wait to see the rest of the line! FollowRead more →
Death Note statues from Sideshow Collectibles
Sideshow Collectibles has the best crafted statues. I would be broke if I looked at their site more often. Today I found these amazing statues of L and Light from the manga/anime Death Note. CraftLabel has actually used real fabric for parts of the character. At 12″ high, Light is pretty impressive. He carries both the Death Note an apple which means that the Shinigami is near by. Light is priced at $79.99 and you can view more pictures and pre-order here. L is an interesting character in Death Note. He's a genius detective that is trying to hunt down the person that is responsible for all the muders. The statue is actually pretty dead on! L is 10″ High and is also priced at $79.99. You can view more pictures and pre-order here. Both statues are a limited edition, which means they could go fast. As usual with SideShow,Read more →
Pre-registering for Anime Expo could win you a trip to Japan
Anime Expo is the largest anime convention on the west coast. Thousands of fans and cosplayers flock there to have fun and spend their money. This year if you pre-register before June 15, 2008 you will be entered into a contest for a trip to Japan! Winners will be announced at Anime Expo 2008's opening Ceremonies which takes place July 3,2008. This year Anime Expo is at the Los Angeles Convention Center in LA, CA. Not one, but two pre-registered attendees will win an all expense paid trip (which includes airfare,hotel and extras) courtesy of Intermixi Japan Tours. Winners will be able to choose from the following tours: · Kame Hame Kansai Tour · Neo Tokyo Tour · Tokyo Game Show Tour My pick would definitely be for the Tokyo Game Show. If you would like to read more about the individual tours offered you can go to www.intermixi.com forRead more →
Live Action Death Note coming to DVD
Viz has been screening the live action Death Note movie and it's almost ready to be released. While the trailer is in English, the movie will be in Japanese with English subtitles. The dvd is planned for release later in the year. Death Note is an amazing story where Light finds a notebook (Death Note) that gives him the ability to kill anyone at will. He just needs to know their face and their name. L is the detective that is trying to find out who is behind the killing spree. Hit the jump to see the English Trailer: [youtube]mPAJXXZ_HFU[/youtube] FollowRead more →


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$20.99El autor ahonda en los principios y herramientas de la nueva gestión pública, particularmente la estratégica y la de calidad, cruciales para lograr un gobierno competente y eficaz. A lo largo del libro una idea toma forma: la dirección exitosa de la sociedad se sustenta más en actores sociales que en el gobierno y requiere más recursos que los que posee el gobierno.
The Political Economy of Public Sector GovernanceIn The Political Economy of Public Sector Governance, Anthony Michael Bertelli introduces core ideas in positive political theory as they apply to public management and policy. Though recent literature that mathematically models relationships between politicians and public managers provides insight into contemporary public administration, the technical way these works present information limits
$11.19The reputation of the financial industry could hardly be worse than it is today in the painful aftermath of the 2008 financial crisis. New York Times best-selling economist Robert Shiller is no apologist for the sins of finance--he is probably the only person to have predicted both the stock market bubble of 2000 and the real estate bubble that led up to the subprime mortgage meltdown. But in this
Fearful Symmetry - the Fall and Rise of Canada's Founding ValuesIn the 1960s, Canada began a seismic shift away from the core policies and values upon which the country had been built. A nation of "makers" transformed itself into a nation of "takers". Crowley argues that the time has come for the pendulum to swing back - back to a time when Canadians were less willing to rely on the state for support; when people went where the work was rather than waiting for
Business Planning in the Public SectorThis book presents a variety of basic financial calculations ranging from fractions and percentages, using statistics and spreadsheets, to project appraisal techniques. It is ideal for those working in the public sector that need to be able to present information in a way that demonstrates value for money in the provision of public services. The contents include: Basic Calculations; Using
The Power and Independence of the Federal ReserveThe independence of the Federal Reserve is considered a cornerstone of its identity, crucial for keeping monetary policy decisions free of electoral politics. But do we really understand what is meant by "Federal Reserve independence"? Using scores of examples from the Fed's rich history, The Power and Independence of the Federal Reserve shows that much common wisdom about the nation's central
Beyond the Grave, Revised and Updated Edition
The Right Way and the Wrong Way of Leaving Money to Your Children (and Others)This expert, one-of-a-kind handbook shows you how to ensure that your inheritance instructions will be carried out the way you want them to be; protect your children's inheritance from creditors, ex-spouses, addictions, tax troubles, mismanagement, squandering, and other risks of loss; prevent family conflict that can arise when parents die and children divide the "family money"; leave more
Summary: The Fair Tax Book - Neal Boortz and John Linder
Saying Goodbye to the Income Tax and the IRSComplete summary of Neal Boortz and John Linder's book: "The FairTax Book: Saying Goodbye to the Income Tax and the IRS".This summary of the ideas from Neal Boortz and John Linder's book "The FairTax Book" provides a proposal for a new way of raising revenue in the US with FairTax. In their book, the authors explain the concept of FairTax, how it differs from the current tax regime and how it
Public Financial Management and Its Emerging ArchitectureThe first two decades of the twenty-first century have witnessed an influx of innovations and reforms in public financial management. The current wave of reforms is markedly different from those in the past, owing to the sheer number of innovations, their widespread adoption, and the sense that they add up to a fundamental change in the way governments manage public money. This book takes stock of
A U-Turn on the Road to Serfdom
Prospects for Reducing the Size of the StateThis book suggests that drastic reforms are required to reverse the ever-increasing size of the state, a trend experienced in most western nations. The report proposes a reassessment of the scale of government to achieve a reduction in taxation and spending.
Developing the Domestic Government Debt Market: From Diagnostics to Reform ImplementationDomestic government debt markets play a critical role in managing public debt effectively and reducing the vulnerability of developing countries to financial crises. Many aspects of debt markets - money, primary, and secondary markets; a diversified investor base; and sound securities custody and settlement systems and regulation - interact in complex ways and are affected by previous policies and
An Inquiry into the Nature and Causes of the Wealth of States
How Taxes, Energy, and Worker Freedom Change EverythingA passionate, detailed, quantified argument for state-level tax reform An Inquiry into the Nature and Causes of the Wealth of States explains why eliminating or lowering tax burdens at the state level leads to economic growth and wealth creation. A passionate argument for tax reform, the book shows that even states with small populations can benefit enormously with the right policies. The authors'


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We had an amazing (and hilarious) turnout for our Embarrassing .FAMILY Photo contest, held in honor of the launch of the .FAMILY domain extension. Although the competition was fierce, three winners stole the show.
Contestants had to track down an embarrassing, awkward, or just plain strange photo of their family and come up with a .FAMILY domain idea that went along with the photograph. The results were as cringeworthy as they were inspiring.
Without further adieu, we present our Embarrassing .FAMILY Photo winners.


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The NCAA has cleared Mississippi State's baseball program from wrongdoing stemming from allegations that the program practiced too long in 2006 and 2007, MSU compliance director Bracky Brett said today.
"They agreed with our contention that there was no violation," Brett said, adding that the NCAA sent a letter to that effect earlier this month.
The NCAA sent MSU a letter on Dec. 4, 2007, alleging that former MSU coach Ron Polk "conducted baseball practices lasting approximately six to eight hours per day that included 36-inning, inter-squad scrimmages held at the institution's baseball field."
Polk, now a volunteer assistant at Alabama-Birmingham, said the all legations, which came from an anonymous accusation, were nonsense.
"I know that we're not guilty," he said at the time.