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Reviews - Jesmond Park3
Price FromView Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
86% would recommend it to a friend
Customer service
Food quality
Room quality
Good value for money
Really enjoyed my stay.
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Hotel stay for Newcastle University graduation trip
Stayed with my family in a family room at this hotel.
The staff were kind, helpful and pleasant. The breakfast in the morning was satisfactory. All in all, it was value for money. However, the only problem was with the shower in our room, which was partially clogged, which made the water in the shower gather up fairly fast, cutting the shower short. Otherwise, it was decent.
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Wonderful NE Greeting
Ive come to be really fond of the NE and this stay only added to that fondness.
All the staff were terrific, the room was great and I would recommend this to anyone staying in the Newcastle area.
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Frank's The Man!
Very helpful & friendly.
Will definitely go back if we are in Newcastle again!
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Was expecting abit of a dump when I read some of the reviews.but was surprised it was clean and tidy the breakfast was great and our hosts very pleasant would stop again
I went up to Newcastle for the weekend and the B and B was lovely
The staff who work there where lovely
The food was amazing
I would recommend this to people
Great stay!
Friendly, personal, clean.
Recommend highly.
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lovely family run place
Just had a great 3 night stay here.
Room was clean and comfortable, staff were incredibly helpful and welcoming.
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Good for a weekend break
Very clean little hotel.
I only had a single room with a shared bathroom but everything was as it should be. Free Wi-Fi. Good quality breakfast. Decent parking on the street but was reminded at every opportunity that I had to return my parking permit. Seriously, do not forget to take your parking permit back. Would definitely stay again when in Newcastle as it was quiet and ideal for my busy weekend of working. Recommended for the price.
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Jesmond Park
The night man was fantastic, he was very friendly and hospitable.
He had good knowledge of the best places to go and eat with children. He was very helpful and obliging, nothing was too much trouble. All the staff were great, all helpful and couldn't do enough for you. The only slight issue was the size of the room, there wasn't a lot of room to manoeuvre as the beds were very close together. Otherwise nice room with all amenities. Definately would return to the hotel if we wanted to go back.
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Wednesday, 19 December 2012
To Algeria, the French brought modern agricultural methods, built the first schools and universities, constructed and outfitted the first hospitals and the fruits of modern medicine, and the only vehicle the inhabitants of the Maghreb now possess for access to the greater world of Western civlization (its art, its literature, its science and technology).
What did Algeria bring to France? It has been the chief source, for France, of unwanted millions of sullen Muslim immigrants whose presence is costing the French state a fortune, disrupting schools - both classroom discipline and the curriculum have suffered, making daily life, for those French who come most often in contact with, and have to deal with, Muslim North Africans, in a state of permanent agitation and subdued fury. And that presence represents, too, a growing and obvious danger not only to the mental and emotional wellbeing of the French, but to their physical security.
Who should be doing the apologizing? Who has the justified grievance?
ALGIERS (Reuters) - President Francois Hollande refused on Wednesday to apologize for France's colonial past in Algeria, saying instead that Paris wanted to move forward on an equal footing and boost trade with the oil-rich North African nation.
Posted on 12/19/2012 4:01 PM by Hugh Fitzgerald
20 Dec 2012
The speed and completeness with which the Algerians dismantled everything the French brought is staggering. But then, they don't need food, clean water and modern hospitals - they have islam. Send the North Africans back to North Africa and let the French retain France.

subset: commoncrawl


text:
- Report: #1633
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Town-village merger proposal tabledOctober 05,2013BELLOWS FALLS A plan to merge the Vermont village of Bellows Falls with the town of Rockingham in 2014 has hit a delay.
The proposal would eliminate the Bellows Falls Village Corporation and the Board of Trustees, which would be turned over to the Rockingham Select Board.
Village services, such as police and fire departments, would continue to be supported by village residents through separate fees or taxes.
But some members of the village trustees and town Select Board said at a joint meeting Thursday that the plan doesnt include any details on the financial impact of the merger, the Eagle Times reported. It also doesnt specify any benefits for the town or village.
Paul Obuchowski and Jim McAuliffe, members of the ad hoc committee that developed the plan, said the details would come out in the public hearings. But some Bellows Falls trustees felt the plan lacked enough information to bring it to a public hearing.
Im in favor of just tabling it until there are some financials, said Trustee Charlie Hunter.
Rockingham Select Board Chair Thomas MacPhee agreed to return to village trustees with more information about the merger.MORE IN This Just In
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text:
Recent Research Articles from UNTHSC
Survival Analysis Following Extracorporeal Membrane Oxygenation in Critically Ill Adults: A Nationwide Cohort Study.
Survival Analysis Following Extracorporeal Membrane Oxygenation in Critically Ill Adults: A Nationwide Cohort Study.
Circulation. 2016 May 19;
Authors: Chang CH, Chen HC, Caffrey JL, Hsu J, Lin JW, Lai MS, Chen YS
BACKGROUND: -Extracorporeal membrane oxygenation (ECMO) provides circulatory and respiratory support for patients with severe acute cardiopulmonary failure. The objective of this study was to examine the survival outcomes for patients who received ECMO.
METHODS AND RESULTS: -Adult patients who received ECMO from September 1, 2002 to December 31, 2012 were identified from Taiwan's National Health Insurance Database associated with 1) coronary artery bypass surgery (CABG), 2) myocardial infarction/cardiogenic shock (MI/CS), 3) injury, and 4) infection/septic shock (Infection). A Cox-regression model was used to determine hazard ratios (HR) and compare 30-day and one-year survival rates using the MI/CS group as the reference. The mean age and standard deviation of the 4,227 patient cohort was 57±17 years and 72% were male. The overall mortalities were 59.8% and 76.5% at one month and one year. Survival statistics deteriorated sharply when ECMO was required for more than 3 days. Acute (30-day) survival was more favorable in the Infection (n = 1,076, HR: 0.61, 95% CI: 0.55-0.67), CABG (n = 1,077, HR: 0.68 [0.61-0.75]), and Injury (n = 369, HR: 0.82 [0.70-0.95]) groups. The extended survival rapidly approached an asymptote near 20% for the Infection, MI/CS (n = 1,705), and CABG groups. The pattern of survival for the injury group was somewhat better, exceeding 30% at yearend.
CONCLUSIONS: -Regardless of initial pathology, patients requiring ECMO were critically ill with similar guarded prognoses. Those in the trauma group had somewhat better outcomes. Determining the efficacy and cost-effectiveness of ECMO should be a critical future goal.
PMID: 27199466 [PubMed - as supplied by publisher]
DNA methylation of oxidative stress genes and cancer risk in the Normative Aging Study.
DNA methylation of oxidative stress genes and cancer risk in the Normative Aging Study.
Am J Cancer Res. 2016;6(2):553-61
Authors: Gao T, Joyce BT, Liu L, Zheng Y, Dai Q, Zhang Z, Zhang W, Shrubsole MJ, Tao MH, Schwartz J, Baccarelli A, Hou L
Oxidative stress (OS) is a primary mechanism of carcinogenesis, and methylation of genes related to it may play a role in cancer development. In this study, we examined the prospective association between blood DNA methylation of four oxidative stress genes and cancer incidence. Our study population included a total of 582 participants in the Normative Aging Study (NAS) who had blood drawn during 1-4 visits from 1999-2012 (mean follow up 9.0 years). Promoter DNA methylation of CRAT, iNOS, OGG1 and GCR in blood leukocytes was measured using pyrosequencing. We used Cox regression models to examine prospective associations between cancer incidence and both methylation at the baseline visit and methylation rate of changes over time. Baseline OGG1 methylation was associated with higher risk of all-cancer (HR: 1.43, 95% CI: 1.15-1.78) and prostate cancer (HR: 1.52, 95% CI: 1.03-2.25) incidence. Compared with participants remaining cancer-free, those who eventually developed cancer had significantly accelerated CRAT methylation (p = 0.04) and decelerated iNOS methylation (p<0.01) over time prior to cancer diagnosis. Accelerated CRAT methylation was associated with higher all-cancer incidence (HR: 3.88, 95% CI: 1.06-14.30), whereas accelerated iNOS methylation was associated with lower all-cancer incidence (HR: 0.08, 95% CI 0.02-0.38). Our results suggest that methylation and its dynamic change over time in OS-related genes, including OGG1, CRAT and iNOS, may play an important role in carcinogenesis. These results can potentially facilitate the development of early detection biomarkers and new treatments for a variety of cancers.
PMID: 27186424 [PubMed]
Novel Y-chromosome Short Tandem Repeat Variants Detected Through the Use of Massively Parallel Sequencing.
Novel Y-chromosome Short Tandem Repeat Variants Detected Through the Use of Massively Parallel Sequencing.
Genomics Proteomics Bioinformatics. 2015 Aug;13(4):250-7
Authors: Warshauer DH, Churchill JD, Novroski N, King JL, Budowle B
Massively parallel sequencing (MPS) technology is capable of determining the sizes of short tandem repeat (STR) alleles as well as their individual nucleotide sequences. Thus, single nucleotide polymorphisms (SNPs) within the repeat regions of STRs and variations in the pattern of repeat units in a given repeat motif can be used to differentiate alleles of the same length. In this study, MPS was used to sequence 28 forensically-relevant Y-chromosome STRs in a set of 41 DNA samples from the 3 major U.S. population groups (African Americans, Caucasians, and Hispanics). The resulting sequence data, which were analyzed with STRait Razor v2.0, revealed 37 unique allele sequence variants that have not been previously reported. Of these, 19 sequences were variations of documented sequences resulting from the presence of intra-repeat SNPs or alternative repeat unit patterns. Despite a limited sampling, two of the most frequently-observed variants were found only in African American samples. The remaining 18 variants represented allele sequences for which there were no published data with which to compare. These findings illustrate the great potential of MPS with regard to increasing the resolving power of STR typing and emphasize the need for sample population characterization of STR alleles.
PMID: 26391384 [PubMed - indexed for MEDLINE]
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
PLoS One. 2016;11(5):e0155648
Authors: Odeh AN, Simecka JW
Mycoplasmas cause respiratory diseases characterized by persistent infection and chronic airway inflammation. Mycoplasma lung disease is immunopathologic, with CD4+ Th cells determining both disease severity and resistance to infection. Th2 cell responses promote immunopathology, while Th1 cells confer resistance to infection. However, regulatory CD4+ T cells may also have a role in the pathogenesis of mycoplasma respiratory diseases. We hypothesized Treg cells control the severity of the inflammatory lesions and may also promote persistence of infection. To examine this, BALB/c mice were depleted of CD25+ cells, and had increased disease severity due to Mycoplasma pulmonis infection. Increases in mycoplasma antibody responses and lymphocyte infiltration into lungs also occurred after CD25+ cell depletion. CD4+CD25+ regulatory T cells promoted IFN-γ and IL-17 mycoplasma-specific CD4+ T cell responses in vitro and in vivo, while dampening IL-13+ Th responses. Neither IL-10 nor TGF-ß expression was detected in CD4+CD25+ T cells from lymph nodes. Thus, a regulatory T cell population plays an important role in controlling damaging immune responses in mycoplasma respiratory disease but does not contribute to persistence of infection. It appears that a regulatory T cell population preferentially dampens Th2 cell-mediated inflammatory responses to mycoplasma through a mechanism independent of IL-10 or TGF-ß characteristic of "classic" Treg cells.
PMID: 27175511 [PubMed - as supplied by publisher]
Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein.
Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein.
J Neurovirol. 2016 May 12;
Authors: Rahimian P, He JJ
HIV-1 Tat is an indispensible transactivator for HIV gene transcription and replication. It has been shown to exit cells as a free protein and enter neighboring cells or interact with surface receptors of neighboring cells to regulate gene expression and cell function. In this study, we report, for the first time, exosome-associated Tat release and uptake. Using a HIV-1 LTR-driven luciferase reporter-based cell assay and Western blotting or in combination with exosome inhibitor, OptiPrep gradient fractionation, and exosome depletion, we demonstrated significant presence of HIV-1 Tat in exosomes derived from Tat-expressing primary astrocytes, Tat-transfected U373.MG and 293T, and HIV-infected MT4. We further showed that exosome-associated Tat from Tat-expressing astrocytes was capable of causing neurite shortening and neuron death, further supporting that this new form of extracellular Tat is biologically active. Lastly, we constructed a Tat mutant deleted of its basic domain and determined the role of the basic domain in Tat trafficking into exosomes. Basic domain-deleted Tat exhibited no apparent effects on Tat trafficking into exosomes, while maintained its dominant-negative function in Tat-mediated LTR transactivation. Taken together, these results show a significant fraction of Tat is secreted and present in the form of exosomes and may contribute to the stability of extracellular Tat and broaden the spectrum of its target cells.
PMID: 27173397 [PubMed - as supplied by publisher]
The Risks to Patient Privacy from Publishing Data from Clinical Anesthesia Studies.
The Risks to Patient Privacy from Publishing Data from Clinical Anesthesia Studies.
Anesth Analg. 2016 May 11;
Authors: O'Neill L, Dexter F, Zhang N
In this article, we consider the privacy implications of posting data from small, randomized trials, observational studies, or case series in anesthesia from a few (e.g., 1-3) hospitals. Prior to publishing such data as supplemental digital content, the authors remove attributes that could be used to re-identify individuals, a process known as "anonymization." Posting health information that has been properly "de-identified" is assumed to pose no risks to patient privacy. Yet, computer scientists have demonstrated that this assumption is flawed. We consider various realistic scenarios of how the publication of such data could lead to breaches of patient privacy. Several examples of successful privacy attacks are reviewed, as well as the methods used. We survey the latest models and methods from computer science for protecting health information and their application to posting data from small anesthesia studies. To illustrate the vulnerability of such published data, we calculate the "population uniqueness" for patients undergoing one or more surgical procedures using data from the State of Texas. For a patient selected uniformly at random, the probability that an adversary could match this patient's record to a unique record in the state external database was 42.8% (SE < 0.1%). Despite the 42.8% being an unacceptably high level of risk, it underestimates the risk for patients from smaller states or provinces. We propose an editorial policy that greatly reduces the likelihood of a privacy breach, while supporting the goal of transparency of the research process.
PMID: 27172145 [PubMed - as supplied by publisher]
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.
Br J Pharmacol. 2015 Aug;172(16):3980-4001
Authors: Matsumoto T, Goulopoulou S, Taguchi K, Tostes RC, Kobayashi T
Vascular dysfunction plays a pivotal role in the development of systemic complications associated with arterial hypertension and diabetes. The endothelium, or more specifically, various factors derived from endothelial cells tightly regulate vascular function, including vascular tone. In physiological conditions, there is a balance between endothelium-derived factors, that is, relaxing factors (endothelium-derived relaxing factors; EDRFs) and contracting factors (endothelium-derived contracting factors; EDCFs), which mediate vascular homeostasis. However, in disease states, such as diabetes and arterial hypertension, there is an imbalance between EDRF and EDCF, with a reduction of EDRF signalling and an increase of EDCF signalling. Among EDCFs, COX-derived vasoconstrictor prostanoids play an important role in the development of vascular dysfunction associated with hypertension and diabetes. Moreover, uridine adenosine tetraphosphate (Up4 A), identified as an EDCF in 2005, also modulates vascular function. However, the role of Up4 A in hypertension- and diabetes-associated vascular dysfunction is unclear. In the present review, we focused on experimental and clinical evidence that implicate these two EDCFs (vasoconstrictor prostanoids and Up4 A) in vascular dysfunction associated with hypertension and diabetes.
PMID: 26031319 [PubMed - indexed for MEDLINE]
Identification and localization of lamina cribrosa cells in the human optic nerve head.
Identification and localization of lamina cribrosa cells in the human optic nerve head.
Exp Eye Res. 2016 May 7;
Authors: Tovar-Vidales T, Wordinger RJ, Clark AF
One of the central features of glaucoma is progressive cupping and excavation of the optic nerve head (ONH). Unmyelinated retinal ganglion cell (RGC) axons exit the eye through the ONH, which is supported by the lamina cribrosa (LC) consisting of plates of connective tissue with channels for bundles of RGC axons. The LC progressively remodels during glaucoma, but the cellular and molecular mechanisms responsible for this remodeling are poorly understood. Two major cell types have been isolated and cultured from the human ONH, which differ in their characteristics. Glial fibrillary acidic protein (GFAP) positive ONH astrocytes are the major cell type and are reactive in glaucoma. GFAP negative LC cells are the second major cell type isolated from the human ONH, and in contrast to ONH astrocytes, are α-smooth muscle actin (α-SMA) positive. Although a number of in vitro studies have been conducted with LC cells, to date there has been no direct evidence for these cells in situ in the human ONH. We used GFAP and α-SMA immunofluorescent staining of human eyes to clearly demonstrate the presence of not only ONH astrocytes within the human ONH, but also LC cells within the cribriform (e.g. laminar) plates/beams of the LC region. Both of these cell types likely play important roles in the homeostatic maintenance of the ONH and pathogenic changes that occur in primary open angle glaucoma (POAG).
PMID: 27167365 [PubMed - as supplied by publisher]
Human trabecular meshwork cells express BMP antagonist mRNAs and proteins.
Human trabecular meshwork cells express BMP antagonist mRNAs and proteins.
Exp Eye Res. 2016 May 7;
Authors: Tovar-Vidales T, Fitzgerald AM, Clark AF
Glaucoma patients have elevated aqueous humor and trabecular meshwork (TM) levels of transforming growth factor-beta2 (TGF-β2). TGF-β2 has been associated with increased extracellular matrix (ECM) deposition (i.e. fibronectin), which is attributed to the increased resistance of aqueous humor outflow through the TM. We have previously demonstrated that bone morphogenetic protein (BMP) 4 selectively counteracts the profibrotic effect of TGF-β2 with respect to ECM synthesis in the TM, and this action is reversed by the BMP antagonist gremlin. Thus, the BMP and TGF-β signaling pathways antagonize each other's antifibrotic and profibrotic roles. The purpose of this study was to determine whether cultured human TM cells: (a) express other BMP antagonists noggin, chordin, BMPER, BAMBI, Smurf1 and 2, and (b) whether expression of these proteins is regulated by exogenous TGF-β2 treatment. Primary human trabecular meshwork (TM) cells were grown to confluency and treated with TGF-β2 (5 ng/ml) for 24 or 48 h in serum-free medium. Untreated cell served as controls. qPCR and Western immunoblots (WB) determined that human TM cells expressed mRNAs and proteins for the BMP antagonists proteins: noggin, chordin, BMPER, BAMBI, and Smurf1/2. Exogenous TGF-β2 decreased chordin, BMPER, BAMBI, and Smurf1 mRNA and protein expression. In contrast, TGF-β2 increased secreted noggin and Smurf2 mRNA and protein levels. BMP antagonist members are expressed in the human TM. These molecules may be involved in the normal function of the TM as well as TM pathogenesis. Altered expression of BMP antagonist members may lead to functional changes in the human TM.
PMID: 27167364 [PubMed - as supplied by publisher]
Letter to the Editor: comments on biostatistical power of sibling analysis by STR markers.
Letter to the Editor: comments on biostatistical power of sibling analysis by STR markers.
Int J Legal Med. 2016 May 11;
Authors: Chakraborty R
PMID: 27166704 [PubMed - as supplied by publisher]
Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz.
Molecular mechanisms of serotonergic action of the HIV-1 antiretroviral efavirenz.
Pharmacol Res. 2016 May 5;
Authors: Dalwadi DA, Kim S, Amdani SM, Chen Z, Huang RQ, Schetz JA
Efavirenz is highly effective at suppressing HIV-1, and the WHO guidelines list it as a component of the first-line antiretroviral (ARV) therapies for treatment-naïve patients. Though the pharmacological basis is unclear, efavirenz is commonly associated with a risk for neuropsychiatric adverse events (NPAEs) when taken at the prescribed dose. In many patients these NPAEs appear to subside after several weeks of treatment, though long-term studies show that in some patients the NPAEs persist. In a recent study focusing on the abuse potential of efavirenz, its receptor psychopharmacology was reported to include interactions with a number of established molecular targets for known drugs of abuse, and it displayed a prevailing behavioral profile in rodents resembling an LSD-like activity. In this report, we discovered interactions with additional serotonergic targets that may be associated with efavirenz-induced NPAEs. The most robust interactions were with 5-HT3A and 5-HT6 receptors, with more modest interactions noted for the 5-HT2B receptor and monoamine oxidase A. From a molecular mechanistic perspective, efavirenz acts as a 5-HT6 receptor inverse agonist of Gs-signaling, 5-HT2A and 5-HT2C antagonist of Gq-signaling, and a blocker of the 5-HT3A receptor currents. Efavirenz also completely or partially blocks agonist stimulation of the M1 and M3 muscarinic receptors, respectively. Schild analysis suggests that efavirenz competes for the same site on the 5-HT2A receptor as two known hallucinogenic partial agonists (±)-DOI and LSD. Prolonged exposure to efavirenz reduces 5-HT2A receptor density and responsiveness to 5-HT. Other ARVs such as zidovudine, nevirapine and emtricitabine did not share the same complex pharmacological profile as efavirenz, though some of them weakly interact with the 5-HT6 receptor or modestly block GABAA currents.
PMID: 27157251 [PubMed - as supplied by publisher]
Target engagement and drug residence time can be observed in living cells with BRET.
Target engagement and drug residence time can be observed in living cells with BRET.
Nat Commun. 2015;6:10091
Authors: Robers MB, Dart ML, Woodroofe CC, Zimprich CA, Kirkland TA, Machleidt T, Kupcho KR, Levin S, Hartnett JR, Zimmerman K, Niles AL, Ohana RF, Daniels DL, Slater M, Wood MG, Cong M, Cheng YQ, Wood KV
The therapeutic action of drugs is predicated on their physical engagement with cellular targets. Here we describe a broadly applicable method using bioluminescence resonance energy transfer (BRET) to reveal the binding characteristics of a drug with selected targets within intact cells. Cell-permeable fluorescent tracers are used in a competitive binding format to quantify drug engagement with the target proteins fused to Nanoluc luciferase. The approach enabled us to profile isozyme-specific engagement and binding kinetics for a panel of histone deacetylase (HDAC) inhibitors. Our analysis was directed particularly to the clinically approved prodrug FK228 (Istodax/Romidepsin) because of its unique and largely unexplained mechanism of sustained intracellular action. Analysis of the binding kinetics by BRET revealed remarkably long intracellular residence times for FK228 at HDAC1, explaining the protracted intracellular behaviour of this prodrug. Our results demonstrate a novel application of BRET for assessing target engagement within the complex milieu of the intracellular environment.
PMID: 26631872 [PubMed - indexed for MEDLINE]
Bars and nightclubs associated with higher HIV prevalence.
Bars and nightclubs associated with higher HIV prevalence.
Drug Alcohol Depend. 2015 Oct 1;155:31-6
Authors: Rossheim ME, Thombs DL, Suzuki S
BACKGROUND: Alcohol outlet density is positively associated with alcohol consumption and a number of related risk behaviors. However, very little is known about the effects of different types of alcohol outlets on HIV prevalence. The current cross-sectional study examines associations between the number of each type of alcohol outlet and HIV prevalence within 350 cities located in 26 U.S. metropolitan statistical areas.
METHODS: State and local health department and U.S. Census Bureau surveillance data were analyzed from 1056 ZIP codes, where an estimated 39 million people reside. Multilevel negative binomial regression models were used to examine the association between the number of each type of alcohol outlet in ZIP codes and HIV prevalence.
RESULTS: Number of on-premise alcohol outlets within a ZIP code was associated with greater HIV prevalence. In this sample, the presence of one additional on-premise outlet in a ZIP code was associated with a 1.5% increase in the HIV prevalence rate in that location.
CONCLUSION: This study extends previous research by examining the relationship between alcohol outlets and HIV prevalence in a large sample of U.S. ZIP codes. Research is needed to more closely examine the mechanisms by which on-premise alcohol outlets may affect HIV transmission. Effective policies to reduce HIV transmission may include limiting the density of on-premise alcohol establishments.
PMID: 26347407 [PubMed - indexed for MEDLINE]
Comparative molecular genetic analysis of simian and human HIV-1 integrase interactor INI1/SMARCB1/SNF5.
Comparative molecular genetic analysis of simian and human HIV-1 integrase interactor INI1/SMARCB1/SNF5.
Arch Virol. 2015 Dec;160(12):3085-91
Authors: Pyeon D, Price L, Park IW
Human integrase interactor 1 (INI1/SMARCB1/SNF5) is a chromatin-remodeling molecule that binds to HIV-1 integrase and enhances proviral DNA integration. INI1 is also known as a tumor suppressor gene and has been found to be mutated in several aggressive tumors such as rhabdoid and lymphoid tumors. To study the function of simian INI1, we screened and cloned simian INI1 cDNA from B lymphoma cells of rhesus monkeys using RT-PCR. Sequence analysis showed 23 single nucleotide differences compared to the human ortholog, which, however, did not result in amino acid changes, and the amino acid sequence is therefore 100% conserved between human and simian INI1. Two alternatively spliced isoforms, INI1a and INI1b, were also found in simian INI1. These two isoforms did not show any functional difference in HIV-1 proviral DNA integration and nuclear localization, suggesting that the specificity of simian INI1 would not be a factor preventing HIV-1 infection of a simian host. Nevertheless, INI1b is expressed only in established cancer cell lines such as Jurkat and COS-7 cells, and not in primary cells, suggesting that INIlb could be an indicator of cell transformation.
PMID: 26350979 [PubMed - indexed for MEDLINE]
Efficacy of SMS Text Message Interventions for Smoking Cessation: A Meta-Analysis.
Efficacy of SMS Text Message Interventions for Smoking Cessation: A Meta-Analysis.
J Subst Abuse Treat. 2015 Sep;56:1-10
Authors: Spohr SA, Nandy R, Gandhiraj D, Vemulapalli A, Anne S, Walters ST
BACKGROUND: Mobile technology provides new opportunities for health promotion communication. The purpose of this study was to conduct a current and extensive meta-analytic review of SMS (short message service) text message-based interventions for individual smoking cessation.
METHODS: Academic Search Complete, PsycINFO, PubMed, and Scopus were reviewed for articles meeting selection criteria: 1) randomized controlled trials, 2) measured smoking cessation, and 3) intervention primarily delivered through SMS text messaging. Three and 6month follow-up of 7-day point prevalence or continuous abstinence was considered from studies meeting criteria. All analyses were conducted with intention-to-treat. Both fixed and random effects models were used to calculate the global outcome measure and confidence intervals.
RESULTS: Thirteen studies were identified that met inclusion criteria. The studies were found to be homogeneous [Q12=12.47, p=0.14]. Odds ratios based on the random effects models suggested that interventions generally increased quit rates compared to controls, 1.36 [95% CI=1.23, 1.51]. Intervention efficacy was higher in studies with a 3month follow-up compared to 6month follow-up. Text plus programs (e.g., text messaging plus Web or in-person intervention modalities) performed only slightly better than text only programs. Pooled results also indicate message frequency schedule can affect quit rates, in which fixed schedules performed better than decreasing or variable schedules. The use of quit status assessment messages was not related to intervention efficacy.
CONCLUSION: Smoking quit rates for the text messaging intervention group were 36% higher compared to the control group quit rates. Results suggest that SMS text messaging may be a promising way to improve smoking cessation outcomes. This is significant given the relatively wide reach and low cost of text message interventions. Identifying the components that make interventions efficacious will help to increase the effectiveness of such interventions.
PMID: 25720333 [PubMed - indexed for MEDLINE]
Strategies for the Management of Postoperative Anemia in Elective Orthopedic Surgery.
Strategies for the Management of Postoperative Anemia in Elective Orthopedic Surgery.
Ann Pharmacother. 2016 May 4;
Authors: Steuber TD, Howard ML, Nisly SA
OBJECTIVE: To assess the use of oral iron, intravenous (IV) iron, and erythropoiesis-stimulating agents (ESAs) for the prevention and management of perioperative anemia in elective orthopedic surgery patients, and to provide a clinical algorithm for use.
DATA SOURCES: A PubMed and MEDLINE search was conducted from 1964 through March 2016 using the following search terms alone or in combination: orthopedic, surgery, elective, anemia, blood transfusion, iron, erythropoiesis-stimulating agents, and erythropoietin.
STUDY SELECTION AND DATA EXTRACTION: All English-language prospective and retrospective human studies and meta-analyses evaluating oral iron, IV iron, or ESA alone or in combination in elective orthopedic surgery patients were evaluated, provided they reported blood transfusion outcomes.
DATA SYNTHESIS: A total of 9 prospective and retrospective studies and 1 meta-analysis were identified and included. In the preoperative setting, administration of oral iron, IV iron, or ESA alone or in combination to correct underlying anemia led to significantly reduced transfusion rates. Transfusion requirements were generally less with combination therapy (ESA + oral or IV iron). In the short-term perioperative or postoperative period, use of oral or IV iron led to conflicting results, with some reporting a statistically significant reduction in blood transfusions, whereas others reported none.
CONCLUSIONS: In elective orthopedic surgery, IV or oral iron with or without an ESA may provide benefit in prevention of postoperative anemia and results in blood transfusion reduction without significantly increasing the risk of adverse events. These agents should be considered at the lowest effective dose with emphasis on administration prior to planned surgery.
PMID: 27147703 [PubMed - as supplied by publisher]
Impact of air quality guidelines on COPD sufferers.
Impact of air quality guidelines on COPD sufferers.
Int J Chron Obstruct Pulmon Dis. 2016;11:839-72
Authors: Liu Y, Yan S, Poh K, Liu S, Iyioriobhe E, Sterling DA
BACKGROUND: COPD is one of the leading causes of morbidity and mortality in both high- and low-income countries and a major public health burden worldwide. While cigarette smoking remains the main cause of COPD, outdoor and indoor air pollution are important risk factors to its etiology. Although studies over the last 30 years helped reduce the values, it is not very clear if the current air quality guidelines are adequately protective for COPD sufferers.
OBJECTIVE: This systematic review was to summarize the up-to-date literature on the impact of air pollution on the COPD sufferers.
METHODS: PubMed and Google Scholar were utilized to search for articles related to our study's focus. Search terms included "COPD exacerbation", "air pollution", "air quality guidelines", "air quality standards", "COPD morbidity and mortality", "chronic bronchitis", and "air pollution control" separately and in combination. We focused on articles from 1990 to 2015. We also used articles prior to 1990 if they contained relevant information. We focused on articles written in English or with an English abstract. We also used the articles in the reference lists of the identified articles.
RESULTS: Both short-term and long-term exposures to outdoor air pollution around the world are associated with the mortality and morbidity of COPD sufferers even at levels below the current air quality guidelines. Biomass cooking in low-income countries was clearly associated with COPD morbidity in adult nonsmoking females.
CONCLUSION: There is a need to continue to improve the air quality guidelines. A range of intervention measures could be selected at different levels based on countries' socioeconomic conditions to reduce the air pollution exposure and COPD burden.
PMID: 27143874 [PubMed - in process]
Prevalence of Metformin Use and the Associated Risk of Metabolic Acidosis in US Diabetic Adults With CKD: A National Cross-Sectional Study.
Prevalence of Metformin Use and the Associated Risk of Metabolic Acidosis in US Diabetic Adults With CKD: A National Cross-Sectional Study.
Medicine (Baltimore). 2015 Dec;94(51):e2175
Authors: Kuo CC, Yeh HC, Chen B, Tsai CW, Lin YS, Huang CC
The use of metformin in chronic kidney disease (CKD) population has been intensely debated with conflicting evidence. Large population studies are needed to inform risk assessment and therapeutic decision-making. We evaluated the associations among metformin, metabolic acidosis, and CKD in a 10-year nationally representative noninstitutionalized civilian population in the United States.In this cross-sectional study, a total of 2279 diabetic adults aged 20 years or older in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2012 were included and had measurements of serum bicarbonate, sodium, potassium, and chloride. The exposure was metformin use. The outcome was subclinical and severe metabolic acidosis defined by serum bicarbonate <23 mEq/L and anion gap > 16mEq/L and by serum bicarbonate < 20 mEq/L, respectively.The prevalence of metformin use decreased from 67.2% among CKD-1 and -2, 40.6% among CKD-3, to 1.3% among advanced CKD-4 and -5. Across CKD stages up to CKD-3b, we observed a tendency of lower levels of serum bicarbonate that was significant in metformin users with CKD-2 and CKD-3a and marginally significant with CKD-3b compared to nonmetformin users. The corresponding tendency of higher anion gap in metformin users with the estimated glomerular filtration rate >60 mL/min/1.73 m was also observed. In multiple linear regression analysis, metformin was significantly associated with decreased serum bicarbonate levels (β = -0.45, 95% CI: -0.73, -0.17) and increased serum anion gap levels (β = 0.40, 95% CI: 0.19, 0.61). The adjusted odds ratio of subclinical high anion gap and severe metabolic acidosis for metformin users was 1.68 (95% CI: 1.11, 2.55) and 1.31 (0.49, 3.47), respectively. The association between metformin and serum bicarbonate was significantly modified by CKD status. No interaction was found between metformin and CKD stages for serum anion gap and acidosis.Metformin is associated with subclinical metabolic acidosis but not with severe metabolic acidosis. The propensity of serum bicarbonate-lowering effect was intensified in advanced CKD; however, such tendency was not associated with the risk of clinically defined acidosis. Our findings highlight a potential of cautious expansion of metformin use among CKD-3b patients with diabetes meriting further investigations.
PMID: 26705203 [PubMed - indexed for MEDLINE]
Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China.
Epidemiological and clinical profiles of respiratory syncytial virus infection in hospitalized neonates in Suzhou, China.
BMC Infect Dis. 2015;15:431
Authors: Lu L, Yan Y, Yang B, Xiao Z, Feng X, Wang Y, Ji W, Mize M, Hao C, Chen Z
BACKGROUND: This study was designed to explore the epidemiological and clinical profiles of respiratory syncytial virus (RSV) infection in neonates from the Suzhou area of China, taking into consideration how climate factors influence disease.
METHODS: From 2010 to 2014, nasopharyngeal aspirates (NPA) collected from hospitalized neonates with lower respiratory tract infections (LRIs) were screened for seven common respiratory viruses including RSV by direct immunofluorescence assay. Human bocavirus, human metapneumovirus, and mycoplasma pneumoniae were detected by polymerase chain reaction.
RESULTS: Of the 1803 hospitalized neonates analyzed, 20.74 % were found to be infected with RSV. Interestingly, 30 subjects were identified as being coinfected with other viruses. The rate of RSV infection was highestduring thewinter and early spring seasons; however, infection was negatively associated with monthly mean temperature (rs = -0.821, P < 0.0001), total rainfall (rs = -0.406, P = 0.002), and sum of sunshine (rs = -0.386, P = 0.001). Monthly mean temperature was the only independent factor associated with RSV activity, as determined using multivariate regression analysis. Compared with non-RSV neonates, neonates with RSV infection presented more frequently with tachypnea,moist rales, and abnormal chest X-rays requiring supplemental oxygen and extended hospitalization postpartum. Neonatal admittance into the NICU was determined based on prematurity and coinfection with other viruses; two independent risk factors for RSV disease, as determined by multivariate logistic analysis.
CONCLUSIONS: Important as a major cause of LRIs in hospitalized neonate, we found that the subtropical climate of the Suzhou area was associated with RSV activity. The identified risk factors ofsevere disease in neonates with RSV infection should be taken into consideration when implementing disease health interventions.
PMID: 26470889 [PubMed - indexed for MEDLINE]
Motivational tools to improve probationer treatment outcomes.
Motivational tools to improve probationer treatment outcomes.
Contemp Clin Trials. 2015 Jul;43:120-8
Authors: Taxman FS, Walters ST, Sloas LB, Lerch J, Rodriguez M
BACKGROUND: Motivational interviewing (MI) is a promising practice to increase motivation, treatment retention, and reducing recidivism among offender populations. Computer-delivered interventions have grown in popularity as a way to change behaviors associated with drug and alcohol use.
METHODS/DESIGN: Motivational Assistance Program to Initiate Treatment (MAPIT) is a three arm, multisite, randomized controlled trial, which examines the impact of Motivational interviewing (MI), a motivational computer program (MC), and supervision as usual (SAU) on addiction treatment initiation, engagement, and retention. Secondary outcomes include drug/alcohol use, probation progress, recidivism (i.e., criminal behavior) and HIV/AIDS testing and treatment among probationers. Participant characteristics are measured at baseline, 2, and 6 months after assignment. The entire study will include 600 offenders, with each site recruiting 300 offenders (Baltimore City, Maryland and Dallas, Texas). All participants will go through standard intake procedures for probation and participate in probation requirements as usual. After standard intake, participants will be recruited and screened for eligibility.
DISCUSSION: The results of this clinical trial will fill a gap in knowledge about ways to motivate probationers to participate in addiction treatment and HIV care. This randomized clinical trial is innovative in the way it examines the use of in-person vs. technological approaches to improve probationer success.
PMID: 26009023 [PubMed - indexed for MEDLINE]


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18 GIFS That Will Make You Question Reality!
Posted by Break.com Staff on Mar. 31, 2014
If there is ever a Zombie apocalypse, Vinny shows you how to make some defe...
Check out these classy folks as they show off their talents!
Pull up your red diaper and go on an adventure with the best talking animal...
Posted by Break.com Staff on Mar. 31, 2014


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Welcome to the 4th annual Toronto House League Face-Off!
This tournament will be hosted on April 1-3, 2016, at our Oakville Ice Sports facility. This fantastic event features both Select and House League divisions. It's a great way to wrap up your season and enjoy a fun-filled weekend!
Come experience the difference with Canlan Classic Tournaments!
PLEASE NOTE: Due to the Easter Holidays taking place in March, this tournament must take place in April. As a result there has been an increase in price, but it is now taking place on a prime weekend and has been increased to a 5 game guarantee.
Please Review the Important Information Below:
Tournament Features:
* 5 game guarantee
* 5 on 5 format
* 3x12 minute stop time periods
* No gate fees
* A prize for every player
* Player of the Game awards
* Team award for division champions
* Qualified referees
* Tournament staff on site
* Canlan Approved Hotels


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- Report: #1069047
Report - Rebuttal - Arbitrate
Complaint Review: Pocket Hose
Pocket HoseInternet USA
Pocket Hose Pocket Hose is dangerously defective Internet
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These hoses have a terndancy to explode, blow-up or spring leaking holes in as little as 1 use!
My hose sprung multiple leaks after 1 use.
My sister-in-law was badly injured when her Pockethose exploded, caueing hige welts and bruises on her thigh and legs which are till there many weeks later.
If these hoses explode when a child or anyone is using or moving it, they could possible lose and eye or have other serious injury, not to mention that they are just not holding up to even one use in many cases.
There are many many complaints and possibly no help or refund from the manufacturer.
This report was posted on Ripoff Report on 07/22/2013 10:18 AM and is a permanent record located here: http://www.ripoffreport.com/r/Pocket-Hose/internet/Pocket-Hose-Pocket-Hose-is-dangerously-defective-Internet-1069047. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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I like the guy and his cool ads for men's suits and clothing! I smell a rat which poses a problem for shareholders. The company has done great according to the Financial Statements MW has released for public consumption. I have no position in MW, just wondering why the act of "Firing" which does not happen enough in Wall Street took a good CEO down.
I hope he remains as a consultant, he's a cool dude!
Sentiment: Hold
I never bought anything at MW, and never will. They have the rudest sales personnel I've ever had to deal with. Just a bunch of dinosaurs standing around acting like jerks towards the customers.
He gave up the CEO spot two years ago, essentially hand-picked his successor. He's a brilliant, charismatic man who built a great company, but the new CEO (Ewert) and board need to make changes to keep MW moving forward, and all signs point to Zimmer resisting and becoming increasingly shrill in doing so. It's tough for a founder/CEO to recede to a lesser role, but it's got to be done. What good is it to designate a successor if you won't let him succeed you? This was clumsy for the board but I don't see that it had an option.
He wasn't the CEO, and hasn't been for a while. Get your facts right.
Really? Fired for financial impropriety? That doesn't happen. They just invite him to join the club. They're distancing themselves from some liability. Perhaps he was fiddling in the wrong nickers or something.


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Philosophy has a HOT sale running through the end of the day.
First you'll be able to take advantage of their 40% off Summer Sale. But what makes this deal even better is that you can get any sized order shipped FREE!
Just enter promotion code SHIPSFREE on shopping bag page prior to proceeding to checkout to redeem. This promotion is valid for all sales completed by May 4 (11:59 pm est), 2011.


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Along with the department's weekly communications, we launched our first webinar of the year, shared our inaugural "Board Report," and produced the back to school edition of our monthly News You Can Use video. Our webinar on the Elementary...
Board Info
Palo Alto Unified School District (PAUSD) Board of Education has five members who are elected by the public to four-year terms. Elections are held in even-numbered years, and terms are staggered so that two or three seats are open at each election.
You may email the Board members by clicking on the respective 'Contact' button below. Please direct US Mail to each Board member at: Palo Alto Unified School District, 25 Churchill Avenue, Palo Alto, CA 94306. In order to protect your privacy, mail to Board members is collected and given to Board members without being opened by staff.
Board Members
Heidi Emberling
President 2016
(650) 308-4702
Term Expires 2016
Terry Godfrey
Vice President 2016
(650) 387-3210
Term Expires 2018
Melissa Baten Caswell
Board Member
(650) 823-1166
Term Expires 2016
Camille Townsend
Board Member
(650) 493-3410
Term Expires 2016
Ken Dauber
Board Member
(650) 906-4340
Term Expires 2018


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on my Campaign Types I only have one option I don't know why.
the only option I have is Donation and I don't have the all or nothing or Flexible.
I'm using Crowd Funding by Astoundify Version 1.3.1 , Easy Digital Downloads Version 1.6.3, Easy Digital Downloads - PayPal Adaptive Payments Version 1.1


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LA council wants letter grades on food trucks
LOS ANGELES The hundreds of food trucks rolling through the streets of Los Angeles may soon add another item to their menus - an A, B or C grade reflecting the cleanliness of their operations.
The City Council voted unanimously Wednesday to adopt an ordinance requiring that all food trucks operating within Los Angeles display letter grades obtained from the county Department of Health. That's something brick-and-mortar restaurants already do.
If the ordinance is signed into law by the mayor, officials say the grades would be handed out sometime next year.
The county Board of Supervisors adopted a similar regulation last month governing all food trucks that operate within unincorporated areas of Los Angeles County.
The Associated Press


text: Squirrel Hill Urban Coalition and Treasures Dinner and Weekly News UpdateJuly 13, 2016 6th Annual Squirrel Hill Treasure Awards November 2nd, 2016 Each year, the Squirrel Hill Urban Coalition honors one place and three people or organizations that have had a strong impact on Squirrel Hill. They're designated as 'Treasures." Past honorees have included the Manor Theater, Karla Boos of Quantum Theater, Honorable Mayor Sophie Masloff and the Homewood Cemetery. For our 2016 Annual TreasureCONTINUE READING Meghan Poisson-DeWitt


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Game Credits
|Alice's Tea Cup Madness (2010)
|(VP, Marketing)
|Diner Dash 5: BOOM! (2010)
|(VP of Marketing)
|Escape from Frankenstein's Castle (2010)
|(VP. Marketing)
|Love & Death: Bitten (2010)
|(VP, Marketing)
|Gotcha: Celebrity Secrets (2009)
|Hotel Dash: Suite Success (2009)
|(VP, Marketing)
|Valerie Porter and the Scarlet Scandal (2009)
|ClueFinders: Mystery Mansion Arcade (2000)
|(Sr. Brand Manager)
Public Relations
|School Tycoon (2004)
|(Marketing Senior Brand Manager)
Developer Biography
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[add bio]
If you have a portrait of this person, you can upload it to the MobyGames database.
Related Sites
There are no related websites on file for this developer. If you know of any related websites for the person, please consider contributing them.


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Hi I've been getting errors when trying to implement my author profile image to come up in Google search results, I've searched all over the net and Ive given up now and headed here for help.. I'm using Redline theme
I'm seeing this error in Rich Snippets Testing Tool:
Warning: Missing required field "updated".
Warning: Missing required hCard "author".
I've tried edited the single.php file but I can't see the lines:

<?php the_date();?>

Author:
<?php the_author(); ?>

I've tried plugins.. I just can't get it working.. perhaps my theme is different to others :(
Here is my site if it helps: http://tinyurl.com/brjopos


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September 23rd – October 31st
HOURS OF OPERATION: 8:00 am – 5:00 pm THURSDAY – SUNDAY
Admission is $8/person and includes petting zoo, a hay wagon ride, the straw pyramid, tire swings, duck races, barrel train, corn bins and jumping pillow. Pony rides are also available for an additional $4. Pumpkins are $4 any size. Children under 2 are free. Credit cards accepted.
Military Appreciation Weekend is October 1st and 2nd. Bring the whole family, show your military ID and receive $2 off your admission!
Schools, Home-School groups, Churches, Day-cares and Moms groups please call 719-244-7252 for special field trip days and pricing.
One of the most unique experiences we offer as an agricultural entertainment facility is the opportunity to see and pick pumpkins right out of the field. For children especially, we believe this is an important educational experience. The foundation of our Fall Festival is celebrating the harvest, a medley of bright colors and distinctive flavors that epitomize fall. We invite everyone to take some of the fall harvest home with them.


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[UNDER CONSTRUCTION: check back soon!]
What a wonderful country. Could we be any luckier in our southern neighbors?
Get Hank's posts delivered fresh!
"You got to have smelt a lot of mule manure before you can sing like a hillbilly."
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text:
- Report: #937282
Report - Rebuttal - Arbitrate
Complaint Review: Express Toll
Express TollP.O. box 5470 Internet United States of America
Express Toll E470 Public Highway Authority is billing me a late charge with no original charge and I didn't drive on E470, Internet
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Additionally and most importantly, I didn't drive on E470 on the date of the bill.
I drive North to work not south and never use that road, even to get to the air port, I don't use E470 EVER.
This report was posted on Ripoff Report on 09/05/2012 05:23 PM and is a permanent record located here: http://www.ripoffreport.com/r/Express-Toll/internet/Express-Toll-E470-Public-Highway-Authority-is-billing-me-a-late-charge-with-no-original-ch-937282. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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Advertisers above have met our
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When he posted just now I thought I could hear him crying :-(
He is upset because his 10 cents a post career is about to end.
Then again maybe bande might have other plans for him with his camels from Persia.
What's he have to be upset about? According to him he's never had a losing trade.
Don't know, but I thought he said earlier today that he was going elsewhere???


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any suggestion on the plugin to use for comments quicktags?
I tried using the comments quicktags from here
I've downloaded the latest version on the dl page, upload the files and activated it but the quicktags are not showing up on my comments page either. Is there a code or something I should add to my comments template to run it? Thank you :)
I'm using wp 2.0


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DH and I switched our direct deposit information from Navy Fed to USAA and we should be getting it in our USAA account this pay period..
My question is, when there's a pending Direct Deposit, is there an alert of some type like there is with Navy Fed? It shows up above the account balance "Pending Deposit" with the amount and date available.. Is USAA the same? Or similar?
Just want to know what I should expect to see if we get our check there this time. Thanks!


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This page will update automatically
FT: Besiktas 0 Arsenal 0. Aaron Ramsey's dismissal will give Arsene Wenger a selection headache, but a solid display from the Gunners against a determined Turkish side should stand them in good stead for the second-leg.90
Rosicky comes on for Cazorla.90
Tosun comes on for Penktemek as the hosts look for a late winner87
That was Ozyakup's last contribution, as he is replaed by former Fulham man Kerim Frei.83
Ramsey receives a second yellow card for a tug on Ozyakup. Very cynical and not waht the Gunners needed.81
Ozyakup is the next man to go in the book for a challenge on Calum Chambers.76
Tore coming on for the home side, with Sahan making way.74
Alexis Sanchez is replaced by Alex Oxlaide-Chamberlain for the Gunners.72
Chris Green has a message fro the Arsenal boss: 'The Gunners have clearly not addressed their defensive vulnerabilities at the interval as they still look unsteady when Besiktas attack. Sort it out, Wenger!'
James Dunker is assessing the options from the US: 'Watching live commentary at work in unusually balmy San Diego, but not sure who Arsenal can pull from the bench to change the flow of the game. Campbell? Oxlade-Chamberlain? Rosicky? Unfortunately, Arsene tends to be very pragmatic and risk adverse, what is needed is some unadulterated passion.'
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