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Mercyhurst baseball, Slippery Rock split doubleheader
-'Hurst, Rock split: At Slippery Rock, Jon Klein pitched six scoreless innings in Mercyhurst's 1-0 win in Game 1 before Slippery Rock jumped out to an early lead en route to a 4-3 win in the second game.
Mercyhurst (24-14 overall, 9-7 PSAC West) scored the first game's only run when Joe Pantano singled home Kolin McMillen in the fifth inning.
Klein allowed just four hits and struck out three in his six innings. Tanner Delahoy worked a scoreless inning to nail down his first save of the season.
Slippery Rock (22-14, 6-6) exacted revenge in the second game by jumping out to a 4-0 lead after two innings. The Rock's John Shaffer started the scoring with an RBI double in the first before Will Kengor and Graeme Zaparzynski each had RBI singles in the second.
Kyle Hagerich homered for Mercyhurst in the fifth.

subset: commoncrawl


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Out of a desire to not be ignorant
I was 18 when I got pregnant the first time... (First year of college). I finished my first year and dropped out so the man who is now my husband could go to school for a degree in software development. We struggled the first year of my sons life and we had Wic and foodstamps. The college he went to had an extremely high rate of the students getting a job before they even graduated. He had 4 job offers before he ever graduated and had a job lined up after graduation. He now is making high six figures and we do not have a problem paying for anything for our children. Welfare is temporary assistance for people working to make their lives better. I am truly grateful to have received it when we did. We have paid way more taxes then we ever took from assistance.
Now I get how some people get pregnant accidentally, but having multiple children when you can't take care of the ones you have is hard for me to grasp. I am not here to judge anyone and I believe it is their choice. I just hope their children grow up in a house full of love because honestly you can do plenty even when you don't have money. I know I would go hungry before my children ever had to feel even a slight bit of hunger pangs. I grew up poor, but still had a great childhood. Sometimes the simplest activities made me happy. Even though we are doing well, I know it can all be taken from us so fast so I try to teach my kids that time with family is more important then going out and doing/buying stuff. When fun activities are saved for special occasions, they become even more memorable.
Erirac- my good friend is a recent Ivy League PhD chemistry grad; he'd kill to find a job making more than $15/hr. He's been looking for almost 2 years. I hope you find the 100k job you think you will find.
thanks Rainy! I hope it works too..
We were not financially stable, but it was thought things would get better and we'd be able to just get by anyway. I have some major fertility problems and wanted to have a baby while I could. I could not have forseen that my baby would be born prematurely or that the best job my SO could find was 15 hours a week pushing carts at Walmart 1 hour away from home. We did the best we could. He took the only job he could find. We failed financially, but we are rebuilding while we stay with family. He's back in school full time so he can get a better job (at 41 years old) and is working. I also am working. We are saving up so we can move into an apartment of our own and start over again. Sometimes you have to think of what's most important. To us, having a baby was most important and had we waited we may have never been blessed with her.
Yes, there are irresponsible people out there that just push out babies to continue to live off of the government, but there are people who legitimately have "accidents" and need help. I know in a perfect world, everyone would be able to take care of their kids on their own but that's not the case and since these taxes that a good majority of us pay go to pretty much all things assisted, it really isn't anyone's business why anyone has kids.
lexy oscar 032010 eisley 12913
the greatest thing you'll ever learn, is just to love and be loved in return.
J1: 6 years of precociousness!
J2: Challenging the household since Feb 2013!
We pay our taxes, and are fine money wise. Our LO will not do without. Just a little note, because not all of us want to be on state insurance or deal with that bullshit.
working on silver tatas.
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Vengeance and the Panther Queen to play The Village
The funky fivesome will play with Le Galaxie, this Friday February 12
The Hot Press Newsdesk, 09 Feb 2010
In what was only their second outing as a band, Vengeance and the Panther Queen rocked out at the Hot Press/Absolut launch party back in November, and now they're back with a bang, playing upstairs in The Village this Friday.
Made up of four parts Republic of Loose, one part Tara McCormack, this band is definitely one to see.
Also playing on the night are Le Galaxie, who have graced the likes of Electric Picnic, Bud Rising and the IMRO Showcase - with a DJ set afterwards from Jules.
Doors 7.30pm
Tickets cost €10 and are available at the door, or through http://www.wavtickets.com/
All proceeds raised on the night go towards rebuilding Haiti:
For more see:


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- Anonymous
- Estonia, Female, 18-24
- Novice Nomad
- 1 review
The B&B is in an old building, which shows. The location is great, the main market was a 2-minute walk away in case you want fresh food/coffee (PASTRIES). My single room windows showed a bar across the street, so during weekend nights it got really loud. Single room is also quite small, but enough for sleeping in. Common kitchen has fridge, microwave, toaster, kettle and utensils. Water pressure in shower is quite weak, temperature also changes. The receptionist was very nice. Overall pleasant.
- Anonymous
- South Korea, Female, 25-30
- Avid Traveller
- 13 reviews
It was very close to the bus station. and it takes 10 minutes from hostel to old town by foot. The room was very clean and large. The hostel was 2nd floor and there were a lot of stairs but there was no elevators... It was hard time to go up the hostel with my luggage.
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Animals' Voice
– NZ's No.1 pet magazine
Animals' Voice is the official publication of SPCA Auckland and New Zealand's
No.1 pet magazine. It's the perfect publication for animal lovers and those
interested in animal care and welfare.
Animals' Voice is packed with interesting features and articles about animal
care and well-being, and helps support the good work of SPCA Auckland.
Subscribe to Animals' Voice and help support SPCA Auckland.
Animals' Voice app available
The Animals' Voice app is free to download.
Enjoy a free sample edition. Enjoy single issues or subscriptions. Now on sale
in Apple and Android formats, as well as on your PC or Mac computer.
Read Animals' Voice with our digital edition and subscription delivery service.
Take out a digital subscription for instant access to Animals' Voice current
and past issues.
Available from www.animalsvoice.co.nz
In the spring issue
The spring issue of Animals' Voice is on sale now and offers something for
everyone in the family. You'll find a wonderful variety of stories about animals,
their welfare and how we humans can make their lives better. And, as usual,
many wonderful prizes are up for grabs.
You can read about:
- The state of our animal welfare
- Horrors of Yulin dog meat festival
- Bob Kerridge – in-depth profile
- Holistic flea and worm control
- Kennels and catteries
- ... and a whole lot more
PLUS be in to win
- a year's supply of PURINA ONE for your cat or dog
- and choose from plenty of books …
Animals' Voice is the magazine of SPCA Auckland and is a vital source of information about the organisation. By subscribing to Animals' Voice, you're buying the opportunity to learn about animal welfare and how to help the SPCA animals.


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Get an alert when new Miller Anderson dates are announced
An outstanding vocalist and guitarist and an exceptional performer with a CV as long as your arm! He has played with Savoy Brown, Keef Hartley and T Rex in the 70s and is now the front man for the Spencer Davis group.
See more info at milleranderson.co.uk
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This bloke is an entertainer of outstanding capability. English Willie
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Broner Not Sure if Pacquiao Can Recover From KO
By Chris Robinson
Having a conversation with three-division world champion Adrien Broner can be a trying process.
To say that the Cincinnati native is a little brash would be an understatement, and the fact that Broner seems to find his own kind of humor in even the most straightforward of subjects means you might not always get the answers you want from him.
Last month in Indio, Calif., the dialogue with the 24-year old champion was deeper than usual, as our conversation covered such topics as a possible bout with Marcos Maidana, the Floyd Mayweather-Saul Alvarez event, his love for his kids, cherishing the spotlight, and dealing with critics.
Having temporarily relocated to Las Vegas as he dives back into training, with a Maidana clash likely on his horizon, Broner has again been brief and whimsical when interviewed.
Asked for his take on the Nov. 23 Manny Pacquiao-Brandon Rios pay per view event set to take place in Macau, China, Broner seemed to have no recollection of the eight-division champion from the Philippines or his foe.
"Who's that?" Broner asked when questioned about the matchup. "Them one guys?"
Broner didn't watch Pacquiao's devastating knockout loss at the hands of his rival Juan Manuel Marquez this past December but he was able to view some photos of him lying unconscious instantly after the defeat.
"I seen the picture," Broner said. "I thought it was photo shopped. Because he looked like he was planking."
Broner was asked if he feels Pacquiao has recovered from that setback heading into the Rios melee.
"You never know what happens," Broner stated. "Boxing is crazy. You never know what could happen. Maybe he could come back stronger; maybe he can come back not the same.
"It's up to him," Broner added. "He gotta overcome that loss. Some people don't know how to take a loss."
And come Nov. 23, don't expect Broner to be on the edge of his seat during Pacquiao vs. Rios.
"I really don't watch too many people in boxing," Broner explained. "There's only two people in boxing I watch. Floyd and this one little guy. They're saying that he's going to take over boxing after Floyd. I think his name is Adrien Broner."
I was a bit annoyed at the Paulie incident but you have to give it to Broner he is a funny mother****er.Comment by Bushidō on 09-10-2013
[QUOTE=IronMike86;13725691]I agree completely. Broner needs a serious wakeup call. I think Maidana may just give it to him[/QUOTE] I think his wakeup call was Floyd calling him fat on national televisionComment by Frank Ducketts on 09-10-2013
That's how you do it Broner, lmao.Comment by LaBéstia on 09-10-2013
Damn, I hate BronerComment by SaldanaCC on 09-10-2013
Cant stand pac but i say he punishes broner at 147 easy! Broner is good but not great pac is the same nowa days but has true 147 power an 140 speed those two things will cause broners first loss…Post a Comment - View More User Comments (53)


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Wealthy motorvehicle dealership business Giltrap Group has sold two Auckland Toyota dealerships to Rick Armstrong, dealer principal and managing director of Wellington-headquartered Armstrong Group.
Richard Giltrap, Auckland-based joint managing director, said the group had sold the Great North Rd and Mt Wellington dealerships, which sell about 80 new Toyota vehicles a month for around $17,000 to about $70,000.
"Rick Armstrong has been looking to acquire in the Auckland area for some time," said Giltrap, son of executive chairman Sir Colin Giltrap. "It's not part of our strategy, to be fair and unfortunately we lost the CEO of the business. He's gone off to do his own thing," he said, referring to former Giltrap City Toyota CEO Graham McMullan. "We tried an executive search. We were not successful."
Giltrap Group owned the two dealerships for 22 years, Richard Giltrap said.
"We were not a national distributor. Toyota New Zealand, based in Palmerston North, are the importer and distributor and we're just a dealer that sells the vehicles, like over 60 to 70 others," he said.
Sir Colin is on the Rich List estimated to have a $320 million fortune.


text:
Zeiss: Beetle
Our most powerful magnifier yet. Please use responsibly.
Advertising Agency: Y&R Dubai, UAE
Executive Creative Director / Copywriter: Shahir Ahmed
Creative Director / Art Director: Komal Bedi Sohal
Photographer / Illustrator: Groovy Singapore
Published:September 2009
9 comments
CrackerJackWorksSep 17, 2009 - 11:00
oh my
consolidated.dbSep 17, 2009 - 21:26
1. This is clearly scam. It's for a magnifying glass! As if a magnifying glass brand has the budget for the 'x' amount of creative hours spent to develop this.
2. I think it's real cool though.
GuestNov 24, 2009 - 9:25
A scam? I doubt it. Zeiss are huge! I bet their deal with Sony alone pays all the bills!


text:
- Report: #357061
Report - Rebuttal - Arbitrate
Complaint Review: NET DETECTIVE
NET DETECTIVEhdpublising.net Deland, Florida U.S.A.
NET DETECTIVE SCAM RIPOFF WEB USELESS NO WAY TO CONTACT ANYONE Deland Florida
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Fortunatly for me I seen one of the Ripoff Reports that said to contact Net Detective with your confirmation number and to let them know that you would contact your states atty's office if you did not get a refund. I did this with with in twenty four hours and got my refund one week later. I sent an e-mail to Net Detective with confirmation number and told them I already had contacted my states atty office. I received with in minutes an e-mail from Net Detective and a form to fill out. I filled out the form mailed it and contacted my credit card company. Thank you so Much for the Ripoff Report
site and the peoples advice. With out this site and the person who helped me I may not have gotten my money back...Net Detective is like a maze..
Its a never ending battle to get anything from it. Once they take your money your on your own. I couldnt even get passed the password they gave. what tip me off was a constant popup..I looked my blocking popups and
it said this site was unavailable...that was my first and only clue-thats all I needed to proceed to cancel my $14.95 subscription..
Thanks again to the person with the knowledge to tell Net Detective I was going to send a report to the States Atty's Office...This was all taken care of in 7 days...
naples, Florida
This report was posted on Ripoff Report on 07/29/2008 02:20 PM and is a permanent record located here: http://www.ripoffreport.com/r/NET-DETECTIVE/Deland-Florida-32720/NET-DETECTIVE-SCAM-RIPOFF-WEB-USELESS-NO-WAY-TO-CONTACT-ANYONE-Deland-Florida-357061. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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You can now easily put an SW award in your signature/posts like a smilie. Just look for the SW award tab after you tap on the smilie face.Dismiss Notice
Activia 0% and free, but do they work?
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text:
- Report: #841468
Report - Rebuttal - Arbitrate
Complaint Review: Ameritrain
AmeritrainSugartown Road Strafford, Pennsylvania United States of America
Ameritrain Doug Davis Scam- does not keep their promises, misleading, using loans to pay Strafford , Pennsylvania
*Author of original report: Timeline
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While Doug Davis and his clothes and jewelry paraded around the classrooms with his version of Naomi Campbell, nothing was ever said about a money back guarantee, because his students would have all deserved it. The classes were an exercise in speed reading, and the aftermath was an exercise in avoiding bankruptcy. This was a scam like I have never seen before. they wanted nothing to do with me or giving me any assistance in getting a job once I was done. Insultingly dismissive, I had to work two jobs for several years to pay off the debt, and none of those jobs were in IT because the potential employers stated that it was all about already having the IT certifications PLUS the two years experience, DAMMIT!!!
This report was posted on Ripoff Report on 02/18/2012 04:25 PM and is a permanent record located here: http://www.ripoffreport.com/r/Ameritrain/Strafford-Pennsylvania-19087/Ameritrain-Doug-Davis-Scam-does-not-keep-their-promises-misleading-using-loans-to-pay-S-841468. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 Author of original report
AUTHOR: Michael Robinson - (United States of America)
SUBMITTED: Saturday, February 18, 2012POSTED: Saturday, February 18, 2012
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These Beers are UNREAL.
15 Brazilian Soccer Fans Grieving Like The World is Ending
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Man Sent this Image to his Friends, 10 Days Later He was Found Dead in the Exact Same Position
11 People Who Celebrated Too Soon
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Cleaning Windows: Good. Cleaning Windows Like THIS: Bad.
This Artist Really Understands You
"Hase" A Giant Stuffed Pink Bunny Is Decomposing In Italy, Because
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Porky Pig's Speech Pattern, Deconstructed
How To Be A MAN (Or A Woman With Super Good Survival Skills)
There is an ACTUAL Job in Hollywood Called "Green-Screen Fluffer..."
Vin Diesel covers Rihanna's "Stay," and Bares his Damn Heart
Mary Doodles Uses Random Squiggles To Guide Beautiful Drawings
Life Without Breath: A Series of 3D Paintings
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Bullet Impacts at One Million Frames Per Second
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15 Brazilian Soccer Fans Grieving Like The World is Ending
Brazil got crushed today in their World Cup game against Germany. The ending score was 7-1, which is such a trouncing in soccer that Germany could have played their towel boy and some kids from…
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Man Wanted His Village to Have Faster Access to Hospital; Tore Down Mountain by Himself
His name was Dashrath Manjhi, and it took him 22 years. People laughed at him at first. Years into his project they brought him food and tools. When he was finished, they praised him.
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These 3D renderings (Mostly by Jared Krichevsky) are incredible, and does this stuff make anyone else really want a Futurama movie?
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on July 8 2014 9:30am
Where does all the stuff on Amazon.com come from?
Amazon sells tons of stuff. But where does it all come from? Well, places like this:
Jesse Fernandez
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Athletes Fall Down in Accidentally Sexual Positions
In this video, while playing a game of
Jesse Fernandez
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Two Women Get Caught Stealing Someone Else's Stuff at The Beach
Well, this one is weird. These two women are like the Bonnie and Clyde of middle-aged petty theft. I would have never expected that two women easing into their golden years from the comfort of…
Jesse Fernandez
on July 7 2014 8:30am
Porky Pig's Speech Pattern, Deconstructed
You may not know Porky Pig's speech pattern is even impressive until after you watch this video. But after watching, it's clear that this pattern requires some real mastery. Just try doing the Porky Pig…
Jesse Fernandez
on July 6 2014 2:14pm
There is a Park Where You Might Have to Scuba Dive to Your Favorite Picnic Spot
Green Lake in Styria, Austria looks like a beautiful place—complete with relaxing benches, quaint bridges and meandering paths. But there was one small oversight in the design of this park…
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on July 5 2014 9:24am
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Hip-hoppers hope to GOTV
CHICAGO – On a rainy Thursday night, March 25, over 200 young Black adults came together in Chicago's newest community center named in honor of the late Harold Washington.
Pinocchios nose and the lie factory
Opinion Many years ago, Italian children's author Carlo Collodi wrote a story about a wooden marionette, Pinocchio. This story comes to mind when people lie repeatedly – like Pinocchio, we imagine their noses growing as the lies get bigger.
A heroic defense and a cruel system
Opinion The Southern California grocery strikers are true working-class heroes. Seventy thousand held fast to their strike over four and a half months, a remarkable achievement in the current "jobless recovery."
An interview with Father Bourgeois: School of Americas wall of secrecy crumbles
"Hundreds of graduates from the School of the Americas have been involved in the massacre, torture, rape, and disappearance of many thousands of people throughout Latin America," Father Roy Bourgeois, founder of SOA Watch, recently told the World in a telephone interview.
U.S. vetoes criticism of Yassins killing
A resolution at the United Nations condemning the Israeli government's extrajudicial assassination of Sheikh Ahmed Yassin was defeated in the Security Council on March 25 as a result of a U.S. veto, prompting many Palestinians to charge that Washington was giving a green light to Israel's policy of "targeted killings."
Paul Robeson stamp celebrated nationwide
OAKLAND, Calif. – Merritt College, a community college with a long history of engagement in people's struggles, was the site Feb. 18 for Oakland's "unveiling" of the Black Heritage series stamp honoring civil rights and civil liberties hero Paul Robeson.
Veterans unveil Iraq War memorial wall
SACRAMENTO – In an emotional ceremony followed by the playing of taps, members of Veterans for Peace unveiled a graphic, oversized "Iraq War Memorial Wall" next to the Vietnam War Memorial at the California State Capitol on March 21.
Bushs 9/11, Iraq actions: Bogus and misleading
On the one-year anniversary of her husband's death in Iraq, the widow of Army Specialist James Kiehl, 22, who was killed in the attack in which Pvt. Jessica Lynch was captured, accused President Bush of "lying to America."


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Beth Segers '81 launched Pie R Squared, a tutoring program for students anywhere from 3rd to 12th grade, after realizing there was a great need for math support outside of the classroom.
School of Public Policy Professor Kathryn McDermott, Department of Educational Policy, Research & Administration
School of Public Policy Professor Kathryn McDermott, Department of Educational Policy, Research & Administration
Formerly known as the Center for Public Policy & Administration (CPPA), the establishment of the School of Public Policy (SPP) was approved by the UMass Board of Trustees in September 2015. The Class of 2016 will be the first graduates of the new School.
Dr. McClaurin will be on campus on Tuesday, April 5 2016, to talk to students about careers in anthropology. McClaurin is the chief diversity officer for Teach For America, a nonprofit organization working to strengthen the movement for educational equity and excellence. She is also an activist anthropologist, writer, poet and educator.
Andrew Mack and Brendan Moore, two students with similar career aspirations, will be tasked with two very different areas of work over the next two years. Mack, also a nutrition major, will be traveling to Belize to become a Health Resource Advisor, working with administrative health and schools to educate them about non-communicable diseases. Moore, on the other hand, will be going to Africa to teach secondary math…in French
Vigneau developed Humans of UMass Amherst as a way to both foster and showcase community at UMass and give people a glimpse into the lives of those around them. He believes that Humans is a thoughtful and intimate way for the rest of the world to see UMass, conveying the idea that "everybody can find a place here; that's the beauty of this school."
The ARC is an academic advising office on campus that serves students in the College of Social and Behavioral Sciences. Thompson 128's doors are open to students seeking advice on graduation and major requirements, internship and career guidance, study abroad opportunities, and much more.
On Thursday, April 5, 2016, the Pioneer Valley will premiere Media Education Foundation's (MEF) newest documentary film about Israel's decades-long propaganda war in the U.S. at UMass, and will be accompanied by a Q&A by Sut Jhally of the Department of Communication.
"Before becoming a Peer Advisor, I had never had the opportunity to work individually with my peers simply to aid them in their pursuit of goals as students and as individuals. Through that I have also learned more about myself as a person. I have learned some of my weaknesses along with some of my strengths as an individual."
The Food for Thought series is a part of the College of Social and Behavioral Sciences' initiative to connect students with alumni on campus.
Political Science Professor Jane Fountain's white paper, Building an Enterprise Government: Creating an Ecosystem for Cross-Agency Collaboration in the Next Administration, makes recommendations for building enterprise approaches in government. It was published on Monday, March 14, 2016 jointly by the Partnership for Public Service and IBM Center for the Business of Government
©2016 University of Massachusetts Amherst • Site Policies • Site Contact


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David Sables
David Sables is CEO of Sentinel Management Consultants.
Recent stories
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So something good DID come of the Tesco investigation
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In selling, information is king and the best source of customer information is, of course, your customer
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- Report: #1142416
Report - Rebuttal - Arbitrate
Complaint Review: streetlowrider.com
streetlowrider.com7416 firestone blvd downer, California USA
streetlowrider.com sold me a wheel for a geared bicycle not a lowrider downey California
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I really got on their website and ordered a 26in 72 spoke lowrider bicycle cruiser rim their description of the product implies that this is for a single speed bicycle either beach cruiser or a lowrider bicycle neither of theres are built with gears and the front arrived wheel arived with grind marks clearly visible on the rim showin a badly made product
This report was posted on Ripoff Report on 04/28/2014 02:24 PM and is a permanent record located here: http://www.ripoffreport.com/r/streetlowridercom/downer-California-90241/streetlowridercom-sold-me-a-wheel-for-a-geared-bicycle-not-a-lowrider-downey-California-1142416. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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I need particular help with selecting specific plugins that will work together. I need a calendar plugin in which will be used for setting up events that will be used for a video class. I also need help choosing a plugin that will hold & set the video class for subscribers only. I also need a plugin that will require revolving payments on a monthly basis. The calendar & setting up times for the classes.
Thank you,


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Skip To Main Content
Main Content
Henderson, Nevada is a popular suburb on the southeast side of metropolitan Las Vegas that many celebrities call home. It has consistently been ranked as one of the best places to live in the U.S. Henderson has many parks, recreational facilities and over 37 miles of trails. Henderson has also been noted as one of the top walking cities in America, a great venue for for residents to maintain good health.
Get a Quote
Get a quote on individual and family insurance coverage.
If you have any questions about Nevada health insurance, please don't hesitate to call your local Anthem Agent or call a licensed agent. He/She can assist you with:
Log in or use your Anthem ID card to make sure you find a doctor or hospital in your network, which will help keep your costs down.
Note: If you are a member with Medicaid or other state-sponsored programs, search with the alpha prefix (first three letters) of your identification number or search by selecting a plan/network.
If it's not an emergency (and you can't get to your regular doctor) - there are other options for fast, more affordable care.


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Big White Vacation Rentals
Whistler Executive Rentals
Premium 1 Bedroom Suite, Price includes everything, no extra fees, NO TAXES, Free Parking, Free Highspeed Internet, High Def 40 inch TV. Prime Village Location, Gas Fireplace, Balcony, Fully equipped kitchen, including Starbucks ...
Judie and Eugene Herrera
Our "Chili Pepper Suite" is a large two bedroom suite that is Ski in/Ski on the Blackcomb ski slope. This suite looks into the courtyard with private deck and BBQ. King bed, 2 twin beds and queen sleep sofa, sleeps 6. 2 Full ...
Judie and Eugene Herrera
Large two bedroom suite that is Ski in/Ski on the Blackcomb ski slope. This is a quiet, private suite with a large patio and BBQ grill. King bed, 2 twin beds and queen sleep sofa (with built in air mattress), sleeps 6. 2 ...
Sun Peaks Winter Wonderland
SKI IN/SKI OUT. Three bedroom plus very cosy den. Beautiful, fully-equipped, new home in discreet, convenient location; mtn. views; private hot tub; ideal for 1-2 families or professional couples/singles; free wifi internet ...
Creekside - Silver Queen
Don't miss out on this gorgeous, fully updated ski in/out unit; it is fully equipped for a very comfortable stay. It includes too many extras to list! 2 beautifully appointed bedrooms, 1 bathroom, sleeps 5 very comfortably. Nestled ...
Daniel Brandt
This 2 bedroom 2 full bathroom boasts 1496 square feet for you to enjoy.
David & Barb Benson
2 Bedroom plus den, 2 bathroom condo with private hot tub and barbeque at the top of Big White Village in Timber Ridge. 5 beds (doubles and queens) will sleep 8 comfortably and seating for 8 at the dining room table.
Lindsay Geheran
Aspens 2 bedroom luxurious condo located in the Upper Village, with secure private underground parking
Sandra Weber
Cozy log cabin style one bedroom condo. Just steps from gondola. FREE Parking & NO TAXES!
Timbers at Happy Valley
Best luxury 5 star family location on the hill -The Timbers. Fantastic location directly ay Happy Valley tube park, skating rink and gondola. Spoil yourselves with our steam shower, private hot tub and luxury finishings.


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The Key to Success in Tracking Mobile Devices: Symbiosis, Not EspionageMobility
As a shopper enters a store, the retailer uses Wi-Fi to track her movements, interests, and shopping habits, providingRead More
Behind the WiFi Network @ Mobile World Congress 2014: Setting the StageMobility
Every year a new attendance record is set at Mobile World Congress by networkers participating from over 200 countriesRead More
IT Transformation: Avoiding PitfallsData Center
In the last two blogs, I talked about the reasons for IT Transformation, understanding Enterprise Environment andRead More
Children Learn Coding and Collaboration at CiscoCorporate Social Responsibility
"If you want to use the music from Frozen in your game, do you know how to download aRead More
Englewood Cliffs Public Schools System Rolls Out Converged AccessMobility
Englewood Cliffs public schools system, based in Bergen County, New Jersey offers classes to children from K-8 grades. TheRead More
IT Transformation: Understanding environment and business goalsData Center
In my last blog, I established reasons behind today's need for IT Transformation. We know that CIOsRead More


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[This post originally ran, in a slightly different form, in the National Catholic Register in February of 2013.]____________________________________________________________________________PIC ashes on forehead I feel like I can't walk ten feet without bumping into an enthusiastic new convert, which is delightful, and so encouraging! Welcome, everybody! We papists have a little saying: Venite intus; horribilis est! Heh. Anyway, you may be looking forward to your first … [Read more...]
Lenten Rookie Mistakes
Where Be Story Editor?
Roland Joffé's new movie, There Be Dragons, is about half a good movie. What is good is so good that it makes the bad parts doubly frustrating.Let's start with the good. The best part was, happily, Charlie Cox, who plays Opus Dei's founder, Josemaria Escriva. Knowing very little about the actual man, I had none of the mental baggage that can trouble a fan ("That's not how I pictured Mr. Tumnus!"). The Fr. Josemaria he portrays is a strong, happy, humorous man who is not like other men. W … [Read more...]
image source Most serious Catholics have had this experience: all on fire for some bracing, difficult truth that seems central to our lives, we march forward in a fine, fervent frenzy, and rip a new asshole for everyone in the room -- in service of the truth. Because, as it says in scripture, "The Lord thy God wants you to rip everyone a new asshole."The problem with this approach is twofold:(1) People are generally not much swayed by the, "Listen up, jerkwad, and I'll teach you so … [Read more...]
So tell me: Marriage Prep
All this talk about young married couples has sent me on a trip down memory lane, back to the old days when my husband was naught but a boyish husband-to-be, and I was a blushing maiden of 22. And by "maiden," I mean I was 22. Ah, yoot!We did go to marriage preparation classes. They were held by another couple in their comfortable home. It was a little too comfortable, as I recall: they installed me next to the fire in a rocking chair, and I damn near fell asleep every night as they dron … [Read more...]
Time for married priests?
Why doesn't the Latin Rite Church just start ordaining married men again? If men can't or won't stay celibate, then why force the issue? Well, I peeked into the future, when married priests are commonplace, and this is what I heard in the pews: "Well! I see the pastor's wife is pregnant again! What is she trying to prove? Must be nice to pop 'em out year after year, while the parish has to support all those brats." or: "Well! I see another year has gone by and the pastor's wife … [Read more...]
More hope for religious art
Elizabeth Scalia posted a link (on Facebook, not on her blog -- but she always has tons of good stuff, so check it out!) to this sculpture of the Annunciation, by John Collier:(photo source: The Deacon's Bench)I know it's just about impossible to make a judgment based on a photo, but what do you think? My first thought was that it made reference to the statue of Apollo and Daphne by Bernini:(photo source)The artist seems to be stressing the significance of the fig t … [Read more...]
Bless the Lord, O my sole
Guess what? I'm fat. About seven permanent pounds for each kid. I usually manage to lose some between pregnancies, but after baby #8 was born, I just kept gaining.My husband thinks I'm beautiful, but I don't. I hate wearing special sizes with labels like "Curvy Coordinates!" "Luscious Lady Plus!" "Gee, Your Ass Looks Enormous!" Being fat feels bad, but knowing I'm still gaining feels horrible. The real misery is in feeling like I had no control.Many and many a time I've tried to ju … [Read more...]


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Klein 68310 Refrigeration Ratchet Wrench
Klein 68310 Refrigeration Ratchet Wrench
The 68310 includes:
- Klein Model 68310 Ratchet Wrench
- Fully-reversible ratcheting wrench
- Designed for refrigeration packing gland nuts and valve stem sockets
- Great for beam-clamp instillation
- Sizes 3/16" and 5/16" square x 1/4" and 3/8" square
- Quick-flip switch for easy ratchet reversal
- Chrome finish with smoothed edges
- Overall size 5-1/2"
- Lifetime guaranteed ~ made in U.S.A.
Overall Rating for Klein 68310 Refrigeration Ratchet Wrench
I used to have one of these before and it is great. I do HVAC work and it comes in handy for service valves. It beats using an adjustable wrench. Great price too.
Perfect for HVAC work
By Nick from Parsippany, NJ on December 27, 2014
Pros:Easy to use.
Great price.
Perfect for what it was designed for.
I would recommend this item to a friend.
Check out the rest of our...
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- Admissions
- Academics
- Research
- University Life
- Alumni
- About
Orientation, Transition and Retention
Anderson Hall, Room 135
Designed for both first year students and transfer students
This two-day program is designed for both first-year and transfer students joining the AU community for the first time in the Spring 2016 semester. The domestic student program will be January 7-8, 2016. Students joining us for the spring semester will receive a letter in the mail inviting them to register for January Orientation.
Students who have been admitted for Fall 2016 will receive a copy of the Eagle Summit Brochure, and should not register for January Orientation. The brochure includes information about the program and how to register and will be mailed out in April or May depending on the date of deposit.
The fee to attend January Orientation is $65.00 per participant (students and family members). Students are advised to bring additional spending money for off-campus dining and evening activities. The $65.00 fee covers breakfast and lunch on the first day, program materials, and activities. Registration for January Orientation will open Tuesday, November 10. To register for orientation, please complete the online registration process at american.edu/ocl/registerforsummit. You can also access the registration page through your New Student Checklist on myau.american.edu.
Orientation cancellations and refund requests must be submitted via email to firstname.lastname@example.com and must be received by 5:00pm EST on Friday, January 1, 2016. All refunds will be posted after the orientation is complete and processed to the same card that made the initial payment.
You will receive a fully detailed schedule at check-in, however we wanted to provide you general information to allow you to make arrangements as needed. Please plan on participating from 8:00am- 5:00pm on Thursday, January 7 and from 9:00am-4:00pm on Friday, January 8. A draft schedule is available here. Please note that the final schedule may be edited, but timing will remain the same.
Throughout the two days, you will hear presentations from your academic program, Housing and Dining Programs, the Career Center, Student Activities, AU Central, the Dean of Students Office, and the Student Health Center. Parents and families are welcome to participate and have a similar schedule. A draft of that schedule is available here.
We also offer a showcase of departments, student organizations, and off-campus organizations. You will be able to speak with them individually and get your questions answered.


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Perot Museum
See photos of the Perot Museum during its construction
Photo: Lara Solt/Staff Photographer
A one-and-a-half ton geode on display that can be opened and closed with the turn of a wheel at the $185-million Perot Museum of Nature and Science which is slated to open in early 2013. Photographed in Dallas on Thursday, February 2, 2012.
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"I classify players as good, great and warriors. James was a warrior. And he took care of so many team problems that coaches have with players."
Related quotes
"They played like warriors. They played like champions. That's why this team is so dangerous when you see the players and the rotation. ... That's what you have to have to be a championship team."
"He had a great game. The guy is a warrior, an absolute champion. He is a great team player. He is exactly what we want all 11 players on defense to be. If we had 11 Bo Smiths, the way that he played Sunday, we'd be a great defense."
""Only as a warrior can one withstand the path of knowledge. A warrior cannot complain or regret anything. His life is an endless challenge, and challenges cannot possibly be good or bad. Challenges are simply challenges.""
"Stacey is a player that I classify as a warrior. She has a severely sprained ankle that she got against Middlebury. A few minutes after, she told me she was OK."
"Chad is the type of player that makes everybody around him better. He's a leader and a warrior on this team."


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Figure 1. According to www.dailymail.co.uk photo (a) is "the Chicago skyline is seen behind a large chunk of ice near North Avenue Beach as cold temperatures remain with wind chills nearing minus 30F on Tuesday". Extreme cold can bring frostbite that could further lead to amputation of toes and other parts of the body, as seen in photo (b) from wikipedia.org.
According to NASA, "polar vortex is a whirling and persistent large area of low pressure, found typically over both North and South poles." In layman's term, we can visualize it as a typhoon that brings in not rain but large amount of snowfall. Northern America has experienced -12F (-24C) wherein the real feel is actually colder than that because of the presence of gust cool winds. This unusual global cooling is actually an effect of the global warming.
Have you ever wondered how this extreme cold and snowfall affects the people experiencing it? Here are some of them:
- People need to wear several layers of baggy and thick clothing.
- People opt to stay indoors where they have electric heater, causing a huge increase in their electric consumption.
- People need to be more cautious since the snow is slippery. It doesn't matter if you're walking or driving, caution is a must.
- Some people might suffer from frostbite which can cause amputation of the affected body parts.
- Some people might suffer from hypothermia which may cause death.
How much do you love your toes and fingers? If going on an extremely cold place, you better protect them because frostbite can lead to amputation of our body parts. Frostbite is a medical condition wherein certain body parts exposed to extreme cold for long hours experienced lack in blood. This leads to freezing of skin and tissues which can eventually lead to death of the tissues that causes amputation of the affected body parts.
There have been news in northern America amounting to few death caused by hypothermia - the opposite of heat stroke. "Hypothermia is a medical condition in which core temperature drops below the required temperature for normal metabolism and body functions which is defined as 35.0 °C (95.0 °F)." (Wikipedia.org) Common causes are long exposure to cold temperature, frequently with alcohol involvement, improper clothing and homelessness during winter season.
If it has been your dream to live in your Winter Wonderland, you should consider certain things before finally migrating. But not everything in winter is downbeat, snowboarding and making your own snowman is certainly fun. What you need to know is just the balance between the pros and cons of living in a country with winter season.
You may also want to take a look at this young scientist who experimented if he's urine would become a yellow snow.


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RUSS 323 A: Revolution: Twentieth Century Russian Literature And Culture
- Spring 2014
Catalog Description:
Explores Russian literature and culture during the twentieth century before perestroika, a period of "revolutions" and unprecedented change in political, cultural, and economic life. Authors include Babel, Bulgakov, Il'f and Petrov, and Nabokov. Periods include symbolism, revolution, Soviet, Stalinist, the "thaw", and post-Soviet. Offered: Sp.
Last updated: April 28, 2016 - 3:37pm


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Today's "Real Fathers, Real Men" winner is Gary Bullock who will be heading to Comic-con.
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TruGlo Tru-Lite
Increase the brightness of your precision bow sight with the Tru-Lite Bow Sight Light from TruGlo®. This easy-to-use light utilizes a violet LED for a gentle light that works great with any color of fiber optic. Light comes with multiple sight housing adapters for 3/8''-32, 3/8''-36, and 7/16''-20 threads to fit sights offered by Copper John, PSE, Spot-Hogg, Trophy Ridge, TRUGLO, Apex Gear, and others. Uses 3 LR4-1.5 V batteries (included).
Manufacturer model #: TG55.
- Violet LED
- LED light has on/off switch
- Easy to use
- Comes with multiple sight housing adapters to fit many different sights
- Uses 3 LR4-1.5 V batteries (included)
Need Help? 7 days a week: 7am to 10pm CT or call 1.800.227.7776 anytime


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Celebrity News
Photos: Joe Ryan, son of former Cowboys assistant coach Rob Ryan, pursues a career in modeling
To post a comment, log into your chosen social network and then add your comment below. Your comments are subject to our Terms of Service and the privacy policy and terms of service of your social network. If you do not want to comment with a social network, please consider writing a letter to the editor.


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Who Put the Beet in the Mousseline?
Published: May 31, 2000
(Page 2 of 2)
Today, most chefs are bringing out better flavor in beets by bypassing the traditional pot of boiling water. Beets are generally roasted in their skins, at 375 to 400 degrees. Some chefs, like Mr. Lohninger, roast them for four or five hours; others for as little as an hour. Those who opt for the long roasting say it concentrates the sweetness, which also depends on the growing conditions and the age of the beets. Baby beets are so tender they can be eaten skins and all.
Joan Hamburg notwithstanding, beets are still not universally admired. Dan Barber, an owner of Blue Hill, said the restaurant recently introduced what it thought was a great early spring combination of pork loin and warm beet salad. ''Most of the waiters said people skipped right over it when they saw the beets,'' he said.
But Mr. Barber said: ''We're definitely going to bring them back when the farmers are ready. There's a part of me that wants people to see the beauty of them, especially when they are babies and filled with sugar.''
For now, he knows to camouflage them in ravioli.
Adapted from ''The Chez Panisse Cafe Cookbook'' (HarperCollins, 1999)
Time: 1 hour 30 minutes
6 medium red or golden beets
Salt and freshly ground black pepper
1 tablespoon red wine vinegar
1 tablespoon, plus 3/4 cup extra virgin olive oil
1 large shallot, finely diced
2 tablespoons white wine vinegar
1 tablespoon lemon juice
1 tablespoon orange juice
1 tablespoon chopped chervil, plus sprigs for garnish
1/4 teaspoon lemon zest
1/4 teaspoon orange zest
2 firm, ripe avocados.
1. Preheat oven to 400 degrees. Trim and wash beets, and put them in a baking dish. Add a splash of water, and cover tightly. Roast 45 to 60 minutes, until tender.
2. Let beets cool, then peel and cut into wedges. Place in bowl, and season with salt and pepper; add red wine vinegar and 1 tablespoon olive oil, and toss gently.
3. Combine shallots with white wine vinegar, lemon and orange juices and pinch of salt. Macerate 15 minutes. Whisk in 3/4 cup olive oil, and stir in chervil and zest. Adjust seasonings.
4. Cut avocados in half lengthwise, and remove pits. Leaving skin intact, cut avocados lengthwise into 1/4-inch-thick slices. Scoop out slices with a large spoon, and arrange on a platter or individual dishes. Season with salt and pepper. Arrange beets on top, and drizzle with shallot mixture. Garnish with chervil sprigs.
Yield: 4 servings.
ROASTED RED BEET AND GOAT CHEESE TERRINE Adapted from Della Femina
Time: 50 minutes, plus 2 hours' roasting time and at least 2 hours' chilling time
4 red beets, about baseball size, trimmed
2 pounds soft goat cheese
4 teaspoons minced thyme
4 teaspoons minced rosemary
1 1/2 tablespoons black truffle oil
Salt and fresh black pepper.
1. Preheat oven to 400 degrees. Wrap beets in heavy foil. Roast until easily pierced with a knife, about 2 hours. Cool, then rub off skins with paper towel.
2. Using a mandoline or sharp knife, slice beets as thin as possible. Line an 11-by-3 1/2-by-3-inch terrine with plastic wrap. Line bottom and sides with beet slices, overlapping slightly.
3. Melt goat cheese in double boiler or bowl set over simmering water. Transfer to food processor, and add thyme, rosemary, truffle oil and salt and pepper to taste. Process until smooth.
4. Place goat cheese in a pastry bag without a tip (or use two large spoons), and pipe into mold. Smooth mixture, and top with layer of beet slices. Press gently on top to flatten and compress. Trim any slices that extend above top, to make neat edge. Cover, and refrigerate at least 2 hours, up to two days.
5. To serve, invert chilled terrine onto a plate and remove plastic wrap. Cut terrine into 16 slices, and allow to come to room temperature. Place two slices on each of eight serving plates, accompanied by a mache salad if desired.
Yield: 8 servings.
Adapted from Danube
Time: 45 minutes
1 tablespoon hazelnut oil
1 tablespoon walnut oil
1 tablespoon canola oil
4 beets, a little smaller than a tennis ball, sliced less than 1/16 inch thick
Salt and pepper to taste
1/4 teaspoon caraway seeds
1/2 teaspoon crushed coriander seeds
1 1/2 teaspoons firmly packed, finely grated fresh horseradish
1 1/2 tablespoons Champagne vinegar.
1. In heavy pan, heat all oils until almost smoking. Stir in beets, and cook over high heat, stirring, until coated with oil.
2. Reduce heat to medium. Season with salt and pepper. Stir in caraway and coriander seeds. Continue cooking, stirring occasionally, until beets begin to caramelize and become quite soft, about 20 minutes. If they dry out, add a little more canola oil.
3. Remove from heat, and stir in horseradish and vinegar and at least 2 to 3 tablespoons water. Stir vigorously to scrape up stickiness on bottom of pan. Mixture should not be dry. Adjust seasonings, and cool to room temperature. Serve immediately, or refrigerate and return to room temperature one hour before serving. Serve over mesclun or alongside smoked fish.
Yield: 4 servings.
SALMON AND BEET TARTARE Adapted from Esca
Time: 1 1/2 hours, plus 1 hour for roasting the beets
4 medium beets, washed and trimmed
1 1/2 teaspoons finely chopped fresh chives
1 1/2 teaspoons minced tarragon
1 teaspoon Dijon mustard
3 teaspoons finely chopped shallots
6 teaspoons lemon juice
3 drops Tabasco sauce
2 1/2 tablespoons extra virgin olive oil
Salt and freshly ground black pepper
8 ounces skinned salmon fillet, cut into very small dice
1 1/2 teaspoons finely chopped fresh parsley
Pea shoots for garnish, optional.
1. Preheat oven to 400 degrees. Place beets in small roasting pan with 1/2 cup water. Cover, and cook until tender when pierced with a fork, about 1 hour. Cool, then peel and cut into very fine dice.
2. In a bowl, combine beets with 3/4 teaspoon chives, 3/4 teaspoon tarragon, 1/2 teaspoon mustard and 1 1/2 teaspoons shallots. Add 4 1/2 teaspoons lemon juice, Tabasco and 1 1/2 tablespoons olive oil. Mix well, and season with salt and pepper to taste. Cover and refrigerate.
3. In a medium mixing bowl, combine salmon, remaining chives, tarragon and shallots. Add parsley and remaining mustard and lemon. Add remaining oil, and season to taste. Mix well, cover and refrigerate until ready to serve.
4. To assemble: On each of four serving plates, place 1/4 of the beet tartare in the bottom of a 3-inch ring mold. Top with an even layer of 1/4 of the salmon tartare. Pat gently to compress. Remove ring molds, and garnish with pea shoots if desired.
Yield: 4 servings.
Photo: RED'S NOT THE ONLY COLOR, YOU KNOW -- Beets, so variable in color, are inspiring chefs to mix and match. (Tony Cenicola for The New York Times)(pg. F1); ISN'T IT RICH? -- A creamy goat cheese fondue accentuates the tanginess of deep red beets in a terrine served over a mache salad at Della Femina. (Barbara Alper for The New York Times)(pg. F11)


text:
- Report: #956491
Report - Rebuttal - Arbitrate
Complaint Review: Pasadena Sound
Pasadena Sound1880 East Colorado Boulevard Internet United States of America
Pasadena Sound Pasadena Sound Damaged My Car and Mickey Moused everything! Internet
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it became unsafe to drive and now i have to repair and pay for damages they made and now
wont except anything that they did. its evident that they did because they worked on my car and also
have very mad manors and customer service towards employees they need to be closed down. They also lack on time they say they take to do your car. My car was said to be done in 3days and ended up taking 1 month and 2 weeks. and only reason i did not take my car was due to the fact that i had given him 1200 upfront and 600 pending and either way towards the end i had to give him 200 more to get my car which made it a total of 2000 dollars and yet my car isnt done right. Still they damaged my car like the front bumper...my rim...rear bumper... and my roceker panels...and MICKEY MOUSED! my whole suspension and bent my sway bar links so they can fit. They give services that honestly they dont know how to do there not even licensed to do so!!! NEVER GO TO PASADENA SOUND!! if you have alot of money to give away go there but if you dont then dont go there please its not worth it!!
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text:
Summer's coming to an end, and so are these limited-time sweets. Get your Vanilla Chocolate Chip, Summer Berries, and Van Doren Dark Chocolate Blueberries before it's too late.
Sweet, tangy blueberries & rich dark chocolate.
With the creamy, classic taste of a root beer float.
Delicious fruit flavors in milk and dark chocolate.
Creamy Chocolate Peanut Butter Fudge & crispy Milk Peanut Butter Chips.


text:
10 Shocking TV Exits
Simon Cowell isn't the first star to walk away from a megahit. (Neither was Paula!) Look back at these seemingly unimaginable departures from ''Grey's,'' ''The View,'' ''ER,'' and more
Slide 1 of 10
Simon Cowell on American Idol
It's no secret the Idol impresario wanted to bring his Leona Lewis-producing British hit The X-Factor to the States since he launched it. But we just never realized that he couldn't do both Fox shows at the same time. Come 2011, the only original judge left at the Idol table will be Randy Jackson. And that's a dawg-one shame.
Image Credit: Fox
August 22 2013 — 12:00 AM EDT


text:
|Publication number
|Publication type
|Publication date
|Nov 18, 1975
|Filing date
|Dec 17, 1973
|Priority date
|Dec 9, 1971
|Publication number
|Roseman Theodore J
|Original Assignee
|Upjohn Co
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (3), Referenced by (82), Classifications (14)
|External Links: USPTO, USPTO Assignment, Espacenet
United States Patent [191 Roseman Nov. 18, 1975 PHARMACEUTICAL DEVICES AND METHOD [75] Inventor:- Theodore J. Roseman, Portage,
[731 Assignee: The Upjohn Company, Kalamazoo,
[22] Filed: Dec. 17, 1973 [21] Appl. No.: 425,600
Related US. Application Data [63] Continuation of Ser. No. 206,437, Dec. 9, 1971,
3,566,874 3/1971 Shepherd et a1 128/349 OTHER PUBLICATIONS Mishell et al. Am. J. Obstet. Gynec. 107: 100-107 May 1, 1970, Contraception by Means of a Silastic Vaginal Ring lmpregnated with medroxyprogesterone Acetate.
Mishell et al. Fertility & Sterility 21199-103 Feb. 1970, Contraceptive Effect of Varying Dosages of Progestogen in Silastic Vaginal Rings.
Barkor Candd. Vet. J1. 7/912189-192 Sept. 1966, Progestin Impregnated Vaginal Pessaries for Estrous Cycle Synchronization in Sheep.
Primary Examiner-Shep K. Rose Attorney, Agent, or Firm-John J. Killinger; Roman Saliwanchik [57] ABSTRACT A solid pharmaceutical device formed of a nontoxic resilient polymer and medication releasable therefrom during residence in a living mammal. The device has a nonmedicated core of the polymer encircled by a medicated coating of the polymer. Reduced content of diffusible medication is achieved.
2 Claims, 8 Drawing Figures US. Patent Nov. 18, 1975 Sheet 1 of3 3,920,805
figure f/yure 3 U8. Patent Nov. 18, 1975 Sheet 2 of 3" 3,920,805
figure 5 figure 4 figure 6 4 RATE (mg./day ring) U.S. Patent Nov. 18, 1975 Sheet3 of3 3,920,805
il O o o l l I l l l l l J 4 a 12 1e 20 TIME (Days) In virro release rates of medraxypragesre'rane acetate from dimethylpolysiloxane rings.
0 Ring MM /00 mg. owe/sea f/zroz/g/muf, .05 1'0 Figures 6 0/20 7.
O fP/ng w/ffi 6/.96 mg. 075 arsed /'/2 outer coo/mg,
0s m F/gz/res 4 and PHARMACEUTICAL DEVICES AND METHOD This application is a continuation of Ser. No. 206,437, filed Dec. 9, 1971, now abandoned.
BACKGROUND OF THE INVENTION This invention arises in the field of medicated devices for placement or implantation in a living body. Such devices release the medication whilst the carrier substance of which the device is formed is not absorbed but merely acts as a matrix and is itself substantially unchanged during the time of residence in the body. This is in contrast to release of a medication by solution of the substance used to transport the medication as in an oral or implanted tablet or an aqueous solution or like medicament.
It is known that a rubbery silicone-type polymer provides a nonabsorbed carrier matrix from which medication will diffuse into a surrounding liquid; Dziuk and Cook, Passage of Steroids through Silicone Rubber, Endocrinology, 781208 (1966). US. Pat. No. 3,279,996 discloses the use of a polysiloxane rubber as an implantation agent for devices dispensing diffusible medication. US. Pat. No. 3,545,439 discloses a ring device for body placement containing a resilient polymeric substance such as a polysiloxane or polyurethrane elastomer, also nylon, dacron, teflon, polyethylene. A wide variety of medication for dispensing via the polymeric devices is disclosed in US. Pat. No. 3,279,996 and US. Pat. No. 3,545,439. Other relevant descriptions and disclosures are found in several publications, viz., Folkman and Edmonds, Circulation Research 101632 (1962); Folkman and Long, J. Surg. Res. 432139 (1964) and Powers, J. Parasitology 512153 (Apr. 1965).
Widely varying types of polymeric material are suitable in providing compatible, nontoxic and nonabsorbable properties, for example organopolysiloxane of the linear type converted to rubber by heat curing (vulcanization). These linear organopolysiloxanes are known as the conventional type, for example dimethylpolysiloxane. Likewise suitable are those known as the RTV type which are converted to the rubbery state at room temperature in the presence of a catalyst. US. Pat. No. 3,279,996 describes various conventional silicone rubbers which may or may not contain fillers, such as silica, to enhance tensile strength and the other physical properties of the cured rubber. This patent also describes commercially available RTV silicone rubbers.
Other patent literature shows the preparation of conventional silicone rubbers, illustratively US. Patents Warwick, US. Pat. No. 2,504,137; Konkle et al., US. Pat. No. 2,890,188; and other patents set forth in the US. Pat. to Long et al., No. 3,279,966. Other suitable nontoxic, nonabsorbable, compatible, drugpermeable polymeric materials are, for example, nylon, a polyamide resin made by polymerization of the hexamethylenediamine salt of adipic acid; dacron, a synthetic fiber made by E. I. DuPont de Nemours and Co. from teraphthalic acid and ethylene glycol; teflon, a tetrafluoroethylene polymer manufactured by E. I. DuPont de Nemours and Co.; polyurethane elastomer prepared according to known methods from polyisocyanate and polyhydroxyl material. The polyhydroxyl materials, for example polyesters, polyethers and the like, are reacted with isocyanates to yield rubberlike products for use as rnillable gums or in casting systems or as thermo processable resins. See US. Pat. Nos. 2,871,218 and 2 3,015,650. Another exemplary polymer is polyethylene, prepared by polymerization of ethylene, usually prepared from natural gas or the cracking of crude oil. Modern Plastics Encyclopedia for 1968, Sept. 1967, Vol. 45, No. la, McGrawJ-Iill, New York, N.Y., describes the preparation of the aforesaid suitable plastic materials, especially in reference to their molding qualities, compression molding temperatures, and compression molding pressures. Details on the aforesaid polymers are given in the plastic properties chart of the aforesaid Encyclopedia, pages 29 through 46, inclusive. In reference to the non-absorbability and nontoxic nature of the aforesaid polymeric material, US. Pat. No. 3,272,204 refers to the use of vinyon N, nylon, orlon, dacron, teflon, and the like as nonabsorbably, reinforcing strands for the preparation of prostheses. Such strands have the advantage that they do not become a part of the body tissues. So it is with the improved device of the present invention, which is particularly advantageous because of its ready insertion and ready retention but does not become or form any part of the tissue of the mammal utilizing the device, for example human and animal, such as dogs, cattle, and horses. In this respect, the present device, with its medication contained therein for continued medication as desired, is greatly superior due to economy of medication.
The aforesaid polymeric substances are compatible with a body environment in which they are used in that no breakdown or absorption of the polymer occurs nor is there any deleterious effect on the body environment, only the medication being absorbed for the desired local or systemic effects.
BRIEF SUMMARY OF THE INVENTION This invention relates to an improved pharmaceutical device formed of compatible polymeric substance and containing therein difiusible medication. The device is suited for placement within a living mammalian body, for example man and valuable warm blooded animals such as dogs, sheep, cattle and horses. The medication diffuses through'the polymeric device, is absorbed by the surrounding body fluids and exerts its desired effect as long as the device is retained within the body. The polymeric substance is compatible and nonabsorbable being removable in total unchanged when it is desired to terminate treatment with the medication. Thus, continuing treatment is provided during the bodys retention of the device and treatment is terminated upon removal. The present invention provides improvement by reducing the amount of medication required in the device by locating the medication in an outer coating of polymeric material which encircles a core of nonmedicated polymeric material.
An in vitro method of test utilizes polymeric material, e.g., polysiloxane tubing which is loaded with the par ticular drug and plugged at the ends with polysiloxane cement. After allowing about 48 hours for setting or curing, the filled link of tubing is placed in, for example, 50 ml. of normal saline in a suitable container and shaken at approximately body temperature for about 24 hours. Spectroscopic analysis of the liquid, for example by the isonicotinic hydrazide method for medroxyprogesterone acetate, shows that the drug is capable of permeating through the silastic into the saline material, in which it can be demonstrated by the in vitra test. For in vivo testing, placement of a suitable size device containing a known amount of medicaments, e. g., medroxyprogesterone acetate in a polysi- 3 loxane, molded-rubber ring and retention in the vagina of the monkey for a period of about 2 months shows that the initial content of the drug is appreciably reduced.
An additional, in vivo, technique for determining the suitability of the polymeric material for use in the preparation of the inventive device is as follows: 150 mg. of medroxyprogesterone acetate is well mixed with 615 mg. of polysiloxane elastomer 382 (Dow Corning Company) to prepare resilient containers approximately 4 cm. long and 0.48 cm. in diameter. Different dosages of the drug are obtained by cutting the required length of the material. The material is sterilized and can be inserted subcutaneously into the scapular region of normally cycling female rats. Daily records of vaginal cytology, which reflect the release of the medroxprogesterone acetate, are made for periods of 2 to 6 weeks at dosages of 18.75 mg. for 6 weeks in four animals, 37.5 mg. for 2 weeks in four animals, and 56.25 mg. for 2 weeks in four animals. Cycling is prevented in the otherwise normally cycling female rats. This shows that the active medicament is released by diffusion through the drug-permeable polymer and exerts its physiological efi'ect via the vaginal tract. In addition to the in vivo data in the rats, it was found by measuring the final content of the medicament in the silastic material that average total release of 4.4 mg, mg. and 5.2 mg. occurred from elastomeric carrier material of 0.5, 1.0 and 1.5 cm. in size, respectively.
The amount of medication in each of the devices is that sufficient for bringing about the desired physiologic effect, for example, the amount sufficient for controlling fertility. Given in ranges of active ingredients, suitable amounts for individual drugs in the device are as follows: digitoxin, 5 to 50 mg; triiodothyronine, l to mg.; isoproterenol, 100 mg. to 2 Gm.; atropine, 10 to 250 mg.; histamine, l to 10 mg.; nitrogen mustard, 50 mg. to 2 Gm.; vitamin B 0.5 to 100 mg.; pyrimethamine, 50 mg. to l Gm.; estradiol, 0.5 to 100 mg; progesterone, 50 mg. to 2 Gm.; androstenedione, 50 mg. to 2 Gm.; testosterone, 50 mg. to 2 Gm.; cortisol, 100 mg. to 2.5 Gm.; medroxyprogesterone acetate, 50 mg. to 2 Gm.; melengestrol acetate, 50 mg. to 2 Gm.; chlormadinone, 50 mg. to 2 Gm. The amount of any additive medication, for example locally effective antimicrobial agent, is calculated on the basis of the known amounts useful in similar vaginal applications. Other principal active medicaments are, for example, antiulcer and antisecretory agents, for example methscopolamine, 75 mg. to 2 Gm.; anticoagulant, for example diphenadione, 75 mg. to l Gm.; hypocholesteremic agent, for example 3-methyl-5-isoxazole carboxylic acid, 200 mg. to 2 Gm.; anti-tumor drugs, for example cytarabine, 100 mg. to 3 Gm.; appetite depressant, for example D- amphetamine, 100 mg. to 2 Gm.; tranquilizers and sedatives, thiothixene and haloperidol, 50 mg. to 2 Gm.; hypoglycemic agent, 1 p-2-(5-chloro-o-anisamido) ethyl phenyl sulfonyl-3-cyclohexylurea, 100 mg. to 2.5 Gm.; hypotensive agent, mecamylamine, 100 mg. to 1.5 Gm.; antibacterial and antimalarial agents, 7- deoxy-7(S)-chlorolincomycin, 2 to 7 Gm., N-demethyl lincomycin, 2 to 7 Gm., 4'-pentyl-N-demethyl-7(S)- chlorolincomycin, l to 5 Gm.; antihypertensive agent, for example angiotensin amide, 100 mg. to 2 Gm.; glucocorticoid, for example dexamethasone, 10 to 250 mg.; prostaglandins, for example PGE PGE PGA, as antiulcer and antisecretory agents and for inhibition of blood platelet-stickiness, 0.5 to 10 mg.; PGF for control of fertility, 0.5 20 mg. The aforesaid amounts are ranges of active ingredients to be included in the device, the exact amount depending upon the age, condition of the patient, and the particular effect desired. These amounts are calculated to provide predetermined daily release dosages as follows: for the cardiac stimulant digitoxin, 0.1 to 0.2 mg; for the metabolic stimulant triiodothyronine, 5 to mcg.; for the bronchodilator isoproterenol, 5 to 30 mg; for the antianemia agent vitamin B 10 to 300 mcg.; for the antimalarial pyrimethamine, l to 5 mg; for the estrogen estradiol, l to 500 mcg.; for the progestogen progesterone, 0.1 to 20 mg; for the androgens androstenedione and testosterone, 0.1 to 10 mg.; for the glucocorticoid cortisol, 5.0 to 50 mg; for the progestogens medroxyprogesterone acetate, melengestrol acetate, and chlormadinone, 0.01 to 10 mg.; for the methscopolamine, 3 to 20 mg; for the diphenadione, 3 to 5 mg; for the 3-methyl- 5-isoxazole carboxylic acid, 10 to 30 mg; for the antitumor drug cytarabine, 60 to 300 mg.; for D-amphetamine, 5 to 30 mg; for thiothixene, 2 to 30 mg.; for haloperidol, 2 to 15 mg.; for the hypoglycemic cyclohexylurea compound, 5 to 50 mg; for the hypotensive mecamylamine, 2 to 10 mg; for the antibacterial, antimalarial lincomycin agents, 250 to 500 mg, 250 to 500 mg. and to 300 mg., respectively; for the angiotensin amide, 0.7 to 30 mg; for the dexamethasone, 0.2 to 2 mg; and for the prostaglandins, l to 100 mcg.
Depending upon the anatomyl the anatomy particular species involved, the improved ring device will vary in size, for example in the case of the human from about 60 mm. diameter to about 80 mm. diameter, these dimensions being overall dimensions; the diameter of the actual ring itself will be in the neighborhood of about 5 to 10 mm. In the case where an endless helical spring or flat spring structure is used for additional tensing property, the diameter of this metallic part of the ring will vary with that of the device itself. Overall dimensions of the improved medicated ring for use in other species are approximately as follows: for sheep and swine, 20 to 65 mm.; for dogs, 5 to 50 mm.; for cats, 5 to 30 mm.; for cattle, 50 to 100 mm.; and for horses, 50 to mm. These dimensions are overall dimensions. As will be apparent, the actual diameter of the ring itself varies with the overall size and with the particular species. Suitably the annular devices may incorporate a tab for assistance in removal. The polymeric materials are, as disclosed in the aforesaid Modern Plastics Encylopedia, those that are suitable for molding in manners known to those familiar with this art. Those polymeric materials, for instance the organopolysiloxanes, which are in a liquid state or paste state, can be directly mixed with the drug, for example melengestrol acetate or medroxyprogesterone acetate, and the semifiuid material placed into the mold for compression molding with the addition of a catalyst, for example stannous octoate. In case the device is to contain a spring structure for tension properties, this is usually centered in the semifluid material while it is in the mold and thereafter covered by additional drug-containing polymeric material for the compression moldmg.
BRIEF DESCRIPTION OF THE DRAYVING FIG. 1 is a perspective view of a tangible embodiment of the concept of the invention.
FIG. 2 is a sectional view taken along the line II II in FIG. 1.
FIG. 3 is a perspective view of an alternate embodiment.
FIG. 4 is a photographic cross-sectional view of a ring emodirnent with central core and outer coating.
FIG. 5 is a photographic cross-sectional view of the ring of FIG. 4 after three weeks leaching in distilled water.
FIG. 6 is a photographic cross-sectional view of a conventional ring device without central core and outer coating.
FIG. 7 is a photographic cross-sectional view of the ring of FIG. 6 after three weeks leaching in distilled water.
FIG. 8 is a graphic representation of release rates of medication.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS As set forth in FIGS. 1 and 2 which portray together a preferred embodiment of the invention a device of the invention takes the form of a resilient individual ring 10 for vaginal placement with a centered nonmedicated polymeric core 11 and a polymeric coating 12 containing the medication 13. To avoid too close proximity of the edge of the core to the edge of the ring, a three step molding process is used to provide a precisely centered core as in FIG. 2.
First Step. Add 0.36% by weight of stannous octoate to q.s. dimethylpolysiloxane (Dow Corning Silastic 382). Mix well. Place the mix into two halves of a mold to provide a centered polymeric core of 62.2 mm. outside diameter and 3.6 mm. cross-sectional diameter. Tighten the mold with wing nut. Cure.
Second Step. Place the cored nonmedicated polymeric core into one-half of its mold. Fill one-ha1f of an outer mold (65 mm. outside diameter and 6.4 mm. cross-sectional diameter) with medicated polymeric mixture containing 1.386% medroxyprogesterone acetate and 0.36% stannous octoate. Place the filled one-half over the core of the first step and cure.
Third Step. After the mold of the second step is cured,
the other half of the outer mold is filled with the medicated polymeric mixture. This half plus the cured half of the second step are bonded together and the whole is cured again.
The average weight of the outer coating of 10 rings is 4.49 Gm. with an average core weight of 2.17 Gm. At
6 61.96 mg. As shown in FIG. 8 the release rates are substantially the same despite the lesser overall amount of medication.
Under in vitro and in vivo conditions a zone of depletion results as medication diffuses from the polymer. This zone is void of solid medication particles. In order for the medication to be released from the core ring at the same rate as a completely filled ring, the zone of depletion over the given time interval must not be greater than the distance from the surface of the device to the surface of the core. The dimensions of the placebo core are designed to meet this requirement.
FIGS. 4 and 5 show the zones which result upon use of the ring of FIG 1. In FIG. 4 there is the medication filled outer coating 13 and the inner nonmedicated core 11. After use as shown in FIG. 5 there is a zone of depletion 14 as the medication diffuses out of the coating 12. In the conventionally filled ring of FIG. 6 there is the medication containing area 13 which remains the same in FIG. 7 except for the zone of depletion 14. The zones of depletion 14 in FIG. 5 and also 14 in FIG. 7 are the same.
FIG. 3' is a perspective view of an alternate embodiment of the inventive concept. It is a solid cylinder for implantation. For example, in the ear region of an animal such as a cow.
It will be apparent to those of skill in the revelant art that there are obvious structural variants by means of which the inventive concept can be practiced. Included therein but not limited thereto are a plurality of outer medicated coatings of different concentrations of the same medicament or coatings of different medicaments useful in combination. Also spring or equivalent means can be included in the core to provide tension.
I claim:
1. A solid pharmaceutical device formed as a vaginal ring of a nontoxic resilient medication diffusing organopolysiloxane polymer and an effective vaginal dosage amount of a medication diffusible therein which releases said medication during residence in the vaginal cavity of a living mammal consisting essentially of, in
combination, a nonmedicated central core of said poly-' mer and an encircling finite thickness of a medicated coating of said polymer.
2. The device of claim 1 which is formed of dimethylpolysiloxane with a centered metallic, endless, helical or flat tensioning spring molded in the nonmedicated central core and the diffusible medication is medroxyprogesterone acetate.
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|Anatomically conforming vaginal insert
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|Method of preventing, medicating, and/or treating hypocalcemia of domestic mammal
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|The Massachusetts General Hospital Corporation
|Methods and devices for the sustained release of multiple drugs
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|Nov 1, 2007
|Ahmed Salah U
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|May 22, 2008
|Oct 9, 2008
|Massachusetts Institute Of Technology
|Methods and devices for the sustained release of multiple drugs
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|Nov 20, 2008
|The General Hospital Corporation D/B/A Massachusetts General Hospital
|Methods and devices for the sustained release of multiple drugs
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|The General Hospital Corporation D/B/A Massachusetts General Hospital
|Methods and devices for the sustained release of multiple drugs
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|The General Hospital Corporation D/B/A Massachusetts General Hospital
|Methods and devices for the sustained release of multiple drugs
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|The General Hospital Corporation D/B/A Massachusetts General Hospital
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|Ahmed Salah U
|Intravaginal Devices With a Rigid Support, Methods of Making, and Uses Thereof
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|Mentor Corporation
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|Heterogeneous implantable devices for drug delivery
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|Jun 26, 2013
|Intravaginal devices comprising anticholinergic agents, and methods of making thereof
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|May 27, 1982
|Schering Ag
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|Mar 25, 1981
|Eli Lilly And Company
|Device for drug delivery to ruminants
|May 27, 1987
|Jan 20, 1988
|Kabi Pharmacia AB
|Intravaginal device and method of preparing the same
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|Sep 6, 1989
|Masao Igarashi
|Topical drug delivery systems containing danazol
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|Dec 27, 2000
|Graham Francois Duirs
|Drug delivery system
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|The Population Council, Inc.
|Methods and compositions for emergency contraception using endothelin receptor antagonists
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|Sep 25, 2013
|PregLem S.A.
|Method for treating gynecological diseases
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|Leiras Oy
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|Lectin Biopharma, Inc.
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|Galen (Chemicals) Limited
|Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors
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|Feb 4, 1999
|Galen Chemicals Ltd
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|Dec 29, 2011
|Anu Mahashabde
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|Intravaginal devices comprising anticholinergic agents, and methods of making thereof
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|Preglem Sa
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|Bayer Pharma Aktiengesellschaft
|U.S. Classification
|424/432, 128/832
|International Classification
|Cooperative Classification
|European Classification