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TEXAS FAITH: Is science leading to a new literalism?
British theologian and Anglican cleric Keith Ward contends that the growing role of science in the world, where countries depend upon scientists and inventors to drive their economies, has led to a growing literalism.
Or so reports Michelle Boorstein on the Washington Post's On Faith blog. Writes Boorstein;
"Keith Ward, a British philosopher who was for years the canon of Oxford's cathedral, argued that the rise of science has led in the Judeo-Christian world to two things: literalism, because people no longer value things they can't prove, and secularism, because critical thought can tend to shift people to look at the Bible like any other book.."
(For more about Ward's thinking, you can read the lecture he gave in 2009 about science and religion at this link.)
Let's put aside the secularism point and focus on the scientific angle. We certainly live in a world where science and technology are on the rise. Many of us benefit from that reality, whether through advances in health care, being able to say hello to friends and family around the world through new technologies or learning more about the origins of our universe.
But does Ward have a point? Has science, with its emphasis on empiricism, led to a new literalism, where we value things we can prove more than things we cannot?
JAMES DENISON, Theologian-in-Residence, Texas Baptist Convention
President, Center for Informed Faith
Alfred Lord Tennyson believed that nothing worth proving can be proven. Prove that your children love you. Prove that you love them.
To the degree that Ward is right, our culture is moving in the opposite direction from scientific progress. Advocates of Newtonian physics did indeed view the supernatural as unprovable and therefore irrelevant. But contemporary science has long since left this mechanistic worldview.
Albert Einstein once noted, "The scientist is possessed by the sense of universal causation. . . . His religious feeling takes the form of a rapturous amazement at the harmony of natural law, which reveals an intelligence of such superiority that, compared with it, all the systematic thinking and acting of human beings is an utterly insignificant reflection."
A relationship with God is like any other relationship — we examine the evidence, then take a step that transcends it and becomes self-validating. If I had waited until I could prove that Janet and I should be married, I would still be single. If you needed proof that this essay was worth your time before reading it, you wouldn't have gotten this far.
President Theodore Roosevelt and his good friend, the naturalist William Beebe, sometimes stayed at Roosevelt's family home. They would go out on its lawn at night, searching the skies until they found a particular spot of light behind the Great Square of Pegasus. They would remember together the words: "That is the Spiral Galaxy in Andromeda. It is as large as our Milky Way. It is one of a hundred million galaxies. It consists of one hundred billion suns, each larger than our sun."
Then President Roosevelt would grin at Mr. Beebe and say, "Now I think we are small enough. Let's go to bed." Are we small enough to go to God?
DEAL HUDSON, President, Catholic Advocate, Washington, D.C.
Ward is repeating a point made many times by those who have traced the evolution of ideas, particularly of truth, since the 18th century. Yes, the notion of truth has come to be identified with that which can be empirically proven. But, in point of fact, empirical truth is one of the weakest forms of truth claims, since empirical data is subject to change depending both on material circumstances and the perspective of the investigator.
Once empiricism became dominant, the notion of religious truth, especially biblical truth, was reduced toward a literalism evidenced by such noxious habits as proof-texting. Embedded in the notion of empirical proof is the assumption that other approaches to proof — logical, intuitive, metaphysical, theological — do not lead to truth but something inferior and unreliable. Those who accept this truncated view of the truth of things neither know how the the mind works nor how the world reveals itself to our senses in its manifold ways.
JOE CLIFFORD, Head of Staff and Pastor, First Presbyterian Church, Dallas
Modernism birthed a world that elevated the historic-scientific mode of thinking over all others. It is evident in our education systems as we prioritize subjects that can be objectively tested in order to "measure" education effectiveness. We put premiums on math and science above all other disciplines, yet these represent only one kind of intelligence. Then we measure student performance through standardized tests. As a result of this standardization, our education system no longer develops critical thought or abstract analysis.
Within the world of religion, this lack of capacity for abstract thought has contributed to the rise of fundamentalism. Fundamentalism came about in the early 1900′s as a reaction to the rise of modernism and the historical critical analysis of Scripture.
Led by Presbyterian elder William Jennings Bryan, the Bible was twisted into a science book to combat "Darwinism." Bryan led a crusade to ban the teaching of evolution in public schools, framing the debate as either belief in the Bible's account of creation or belief in science, which equated to atheism.
His crusade was capped by the Scopes Monkey Trial in 1925. In our time, the debate is still framed by literalism, as exemplified by the Texas Board of Education debate in 2009. New atheism has emerged to combat religious fundamentalism. Ironically, both fundamentalists and atheists think in the same category–literalism.
With the advent of post-modernism, we are recovering the ability to think in multiple categories. Post modern philosophers call these frames of thought "meta narratives," grand stories through which we interpret our lives, our purpose, and our existence. In the 1530′s, John Calvin described the Bible as "the lens through which we see the world clearly." Scripture served as Calvin's meta narrative. There are many meta-narratives by which we understand the world. The historic-scientific narrative is one; faith is another. Both offer strengths and weaknesses, both make contributions to the greater good, and both have the capacity to cause great harm.
At its best, faith stands over against the new literalism, offering far more with regard to understanding the meaning and purpose of our existence.
KATIE SHERROD, Independent writer/producer, progressive Episcopalian activist, Fort Worth
I'm not sure I'm buying the thesis that we value that which we can prove more than things we cannot. Our current political discourse is a case in point — just look at all the misinformation people hang on to in the face of proven facts. People tend to cling to those "facts' that help sustain their world view and ignore those that do not.
Having said that, I do believe the human mind is one of God's greatest gifts to us. Seeking to understand the world around us, the heavens above us, and the way our environment affects us and we it is an unstoppable drive in humanity. Quite naturally humans turn to science in hope of finding a cure for cancer, new sources of energy, new ways to feed the growing population of the world.
Believers also look to science to help them carry out the Gospel imperatives of feeding the hungry, clothing the naked, even finding new ways to visit the lonely and the imprisoned. And again and again, science and technology come through. So perhaps it is understandable that for many, science is the place to turn for answers to all those things that trouble us and make us uneasy and afraid when we are alone in the dark.
But I think turning to science alone for all our answers always will be cold comfort and will leave us always yearning for more. There will always be mystery. Scientists can tell us all day about the role hormones and pheromones play in the attraction of one human to another but that does not explain the mystery of love. We can literally take apart a human brain via dissection and still not find the "mind."
And when the doctor tells us we have cancer, science can offer one kind of hope, but faith in God will more reliably see us through our confrontation with mortality.
No matter how much science tells us, there will always be the ineffable numinous moments when we know to the marrow of our bones that there is something more. It is in those moments that God can speak to us.
I deeply value the gifts science and technology bring us, but I value more the faith that allows us a numinous space in which to figure out how to best use those gifts for the good of all, not just the few.
NITYANANDA CHANDRA DAS, minister of ISKCON (International Society for Krishna Consciousness), Dallas
The attraction to modern science is its practicality. Put some food in the microwave, turn it on, and the food comes out hot. No belief, just practical results. Similarly religion is not supposed to be based on belief but rather its ability to produce practical results. The foremost of which is happiness.
Religion without philosophy is simply sentiment or fanaticism and science and philosophy without religion is simply mental speculation. Real faith is attained with practical results.
Therefore I feel that they problem is that religious groups have moved away from practical experiences of a spiritual connection to the realm of blind faith.
WILLIAM LAWRENCE, Dean and Professor of American Church History, Perkins School of Theology, Southern Methodist University
A few decades before the recent death of my mother-in-law, she was advised by her physician that she should have knee replacement surgery. Unhappy with that prospect, she changed doctors. But the new one gave her the same advice. Not long afterward, she encountered a friend who was a school crossing guard. When the friend heard about the possible surgery, she told my mother-in-law that her mother had many problems after a knee replacement operation and advised against it. My mother-in-law decided that she now knew what to do. Having received the answer she wanted, she never had the surgery.
On one level, it seems silly to dismiss the professional advice of knowledgeable physicians and to trust instead a crossing guard. Yet "knowledge" is often acquired not on the basis of critical thinking but on the basis of whom to trust. Sometimes, we only trust the people who give us the answers we want to hear. Their answers confirm (and conform to) what we already believe, what we can emotionally accept, or what fits our prejudice.
That fact has led philosophers, scientists, and theologians (among others) to ask the question, "How do we know what we know?" The term that philosophers and theologians use for this endeavor is "epistemology."
It is true that the scientific method has had an impact on our ways of knowing. Observations of phenomena challenged trusted truths. Christopher Columbus was surely not the first mariner to realize that ships came into view over the horizon with the highest point of the craft being visible first–indicating that the world might be round, not flat. Galileo was not alone in suggesting that the earth moved around the sun, rather than vice versa. The scientific method was an epistemological triumph!
And yet it has hardly won unanimous endorsement. There are plenty of Christian believers in Texas who remain convinced that evolution is an untrustworthy theory. There are plenty of the pesident's political detractors who still maintain doubts about the legitimacy of his birth certificate.
More to the point, the scientific method is like all limited approaches to human knowledge. It cannot arrive at any conclusions which lie outside its own observable realm. For example, it can only deal with the laws of physics that are applicable in this universe of energy and matter. It cannot deal with the knowledge that lies outside the framework of observable reality on our side of cosmic patterns.
Nor can it (yet) answer questions that are only accessible to knowledge based on trust. "When does human life begin?" The answers to that derive from epistemologies that are not resolved by science, even though scientists have assembled on conflicting sides of the answers to that question. The truly defining issues of human values are shaped epistemologically not by what is objectively knowable but by what or whom we trust to provide answers.
DARRELL BOCK, Research Professor of New Testament Studies, Dallas Theological Seminary
The way I would say this is that we value things we can see and touch, rather than what we sense and feel inside. Those things are easier in some ways to categorize and deal with. They can be analyzed and packaged. What we do not sense so immediately with our senses is harder to evaluate and more subject to judgment. So, yes, there is some truth in this.
GEOFFREY DENNIS, Rabbi, Congregation Kol Ami, Flower Mound; faculty member, University of North Texas Jewish Studies Program
Its not just that we value the provable more, we insist on literalism in the way pre-modern people didn't. Take, for example, the controversy over the rapper Common. Poetry can no longer be read as evocative, it must be read as denotative.
What do fundamentalists and enemies of religion share in common? Both insist literalist readings of Sacred Writ as the only valid readings. In the Jewish prayer book, there appears the phrase Baruch Atah Adonai, michayei ha-meitim, "Praised are You, Lord, who revives the dead." This is, of course, the idea of Resurrection so popular in Jewish and essential to Christian eschatology.
Modern Jews have swirling arguments about this phrase, for and against, all fixed on the idea of corpses returning to life. Yet already 1500 years ago the rabbis (Berachot 58b; T.Y. berachot 4:2) advised reciting this blessing when you wake up in the morning and if you run into a friend you haven't seen for at least a year! Humans are creatures who think in metaphor and religion lives in the realm of metaphor. We (both the irreligious and the religious) do it a grave dishonor when we insist that it cannot be poetry, it must be doctrine.
RIC DEXTER, Nichiren Buddhist (Soka Gakkai lay organization)
Buddhist philosopher Daisaku Ikeda explains why this may be a false dilemma. "Although it is probably safe to assign religion to the field of intuition, religion supported by nothing but intuition in unconvincing. When it is illuminated by the light of reason the intuitive knowledge of religion is given realistic life. What we need is rational intuition, and an intuitive kind of reason."
Arnold Toynbee declared "Science and Religion need not and ought not conflict, they are two complementary ways of approaching the universe mentally in order to cope with it".
Science looks at the question of "how" and religion asks "why."
In recent discussions I've spoken about the "six lower worlds," which are the baser instincts within the makeup of all life. This question leads us to the next two inherent life conditions, the worlds of learning and realization. In the world of learning, the "voice hearers" seek truth in the knowledge of predecessors and contemporaries, weighing the collected and discovered empirical evidence. Through realization, the "cause awakened ones" seek lasting truth through intuition. These can be loosely equated to the path of science and the path of religion.
Above these is the path of the Bodhisattva, which is characterized by altruism. In the Lotus Sutra it is taught that while these appear to be three, in truth they are a single path. A science touched by altruism is science to benefit mankind, a religion accepting scientific reason remains vital and relevant. Altruistic action needs to be supported by reason and insight.
Dean Carter, of Morehouse College describes this relationship saying "The consciousness of nonviolence is the common denominator that will bring science and religion together. One is anticipated in the other. You can't have change without this new consciousness."
AMY MARTIN, Executive Director, Earth Rhythms; Writer/Editor, Moonlady Media
Science is full of the theoretical, the imagining of things that can not be empirically proved and holding them as possible until they manifest. Albert Einstein's theory of relativity was accepted and held as true long before it was proved by tests. There is hardly a drop of empiricism in the multiple universes and string theory of physicist Brian Greene. In quantum mechanics, particles created in the laboratory as twins can become entangled entities. Touch one particle and its entangled twin will also react, even if thousands of miles away, and no one knows why.
We live on the paradox planet. Just because someone embraces scientific empiricism doesn't mean they can't be mystically spiritual as well. The website TASTE (The Archives of Scientists' Transcendent Experiences) will dissuade that assumption. The more you know, the more you know how little you know, and the only way to learn more is to leave yourself open to the unknown. As every new truth revealed, another mystery is generated.
An equal affinity with science and mysticism is a hallmark of many spiritual not religious. They are comfortable with the ambiguity that much of life is not known and may never be known, and that to depend on our five entirely fallible senses as the final arbitrator of reality is to intentionally wear blinders. These agnostic folks accept our limited capacity as human beings to grasp the totality of reality. Instead the emphasis is on transcendent experience, to transcend the senses and access spirituality in a wordless way.
A quote from Albert Einstein captures the conundrum: "The finest emotion of which we are capable is the mystic emotion. Herein lies the germ of all art and all true science… To know that what is impenetrable for us really exists and manifests itself as the highest wisdom and the most radiant beauty, whose gross forms alone are intelligible to our poor faculties – this knowledge, this feeling … is the core of the true religious sentiment. In this sense, and in this sense alone, I rank myself among profoundly religious men."
CYNTHIA RIGBY, W.C. Brown Professor of Theology, Austin Presbyterian Theological Seminary
Yes. Ward is right. The rise of science, with its emphasis on empiricism, has led to a new literalism and to a valuing of things we can prove more than things we cannot.
At least in the realm of PUBLIC discourse, that is.
In relation to our PRIVATE lives, I do not think we necessarily value that which can be empirically proven over that which cannot. My love for the members of my family, my concern for my students, my passion for my vocation, my belief in God: I cannot "prove" any of these things, empirically – but I certainly value them and am informed by them more than by most things that can be empirically proven.
The problem Ward is highlighting, as I understand it, is this: we who do value things that cannot be proven do not feel at liberty to bring them – AS SUCH – to the table of public discourse. Thus, those of us who have unmeasurable convictions feel a need either to argue for their measurability (so they will be factored into the conversation) or to leave them to the side as we find other, more empirically-respectable, ways of engaging.
An example of someone who tries to make the unmeasurable measurable might be a person of faith who argues that the story of creation, as it is told in Genesis 1-2, must be taught as a literal, empirically-sound alternative to Darwinism. An example of someone who puts aside things that are unmeasurable in order to be a respected conversation partner might be a person of faith who, believing the creation stories of Genesis are meaningful but NOT literal, therefore complies with the secular opinion that they must be left out of the classroom altogether.
The challenge we face is: How do we include that which is most meaningful, though not literal, in our public deliberations? Forced empirical verifiability distorts and diminishes meaning rather than celebrating it. Holding meaning to the side in the service of civil discourse or in the interest of not looking foolish keeps us from sharing, together, in what might very well matter most to all of us.
We need to refresh, I think, a common commitment to WONDER. Ironically, it could very well be that the drive we have to ponder that which lies beyond anything we can measure can itself be measured. If 99 percent of the population tested positively for wonder, would we find a way to include reflections on our unmeasurable values in our public deliberations? I wonder.
MIKE GHOUSE, President, Foundation for Pluralism, Dallas
The battle between science and religion is a product of the insecurity stamped in to men to view anything different as a threat to their existence and to the resources that surround them. There is a built-in mechanism that propels them to prove, talk, fight and act superior to hide their insecurities, and tempts them to enforce their views on others. Thank God our American system is relatively immune to such invasions.
Science is not an alien object; nor is its goal to falsify religion it's rather a human desire to understand the inexplicable.
Faith in the invisible gives a majority of us comfort that the causer of the universe has created a system that works and we don't need to pull our hair for that. The problem is not with science or religion. The insecurity among us drives the wedge. Finding the truth is our own responsibility and religion is about being truthful.
For a long time literalism was confined to the conservatives among religion. "What they see is what it was," was their ethos. That contagious virus has now hit scientists as well . They are as irrational with their fanaticism as the religious literalists.
About two years ago I joined atheist groups to invite them to be a part of the Unity Day to complete representing every American in the event. I was kicked out of it for believing in God. Such is the literalism in every group be it scientific, religious, spiritual or rational.
We are yet to find a logical scientific reason why we fall in love, why we long for the one when we can have the other, why do we take our shirt off for a friend, why the "noise" of music is mellifluous, why tears roll down when tragedy befalls humanity and why do we risk our own lives to save the other? The scientific observations may not find the causal relationships in affairs of love or belief in God, but may help in understanding Hitlers, Bin Ladens and their likes to mitigate such occurrences.
Ward has indeed made the other point, that the emphasis on empiricism has not led to a new literalism but the rising freedom in our societies has brought the literalists among scientists out of the closets just as acceptance of atheism has graduated over the last two decades.
Literalism is part of the equation in everything we do; science is not an exception, we have to live with all dimensions of life; left to right and moderates. If we can learn to respect the otherness of other and accept the God given (or genetic if that suits you) uniqueness of each one of us then conflicts fade and solutions emerge.
DANIEL KANTER, Senior Minister, First Unitarian Church of Dallas
The bottom line here is that a major theological and practical concept missing in our lives is the value of trust. In our society trust is hard to come by. It is especially hard to find in a society that values the tangible over the intangible, the reasonable over the illogical or intuitive, the practical over the spiritual.
What we need more of is spiritual maturity. And this means having both the capacity to reason but the willingness to listen to the mysteries of life and spirit without immediately seeking the easiest answers we can find be they from within our sacred texts or in our science textbooks. Life is far too complex to lean too far over one way or the other.


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VoIP spam
VoIP spam or SPIT (Spam over Internet Telephony) are bulk unsolicited, automatically dialled, pre-recorded phone calls using the Voice over Internet Protocol (VoIP).[1] Telephone spam is comparable to E-mail spam, but due to its synchronous character, different mitigation methods are needed.
Voice over IP systems, like e-mail and other Internet applications, are susceptible to abuse by malicious parties who initiate unsolicited and unwanted communications. Telemarketers, prank callers, and other telephone system abusers are likely to target VoIP systems increasingly, particularly if VoIP supplants conventional telephony. The VoIP technology provides convenient tools (e.g. Asterisk and SIPp) and low-priced possibilities to place a large number of Spam calls.
The underlying technology driving this threat is Session Initiation Protocol (SIP).[2] This technology has received significant support from most major telecommunication vendors, and is showing signs of becoming the industry standard for voice, video and other interactive forms of communication such as instant messaging and gaming.
VoIP Spam or SPIT is characterized by bulk unsolicited calls using the Voice over Internet Protocol. The spammer attempts to initiate a voice session and then relays a pre-recorded message if the receiver answers. If the prevalent Session Initiation Protocol is used, the sessions are initiated with INVITE messages and the audio data is transferred using the Real-time Transport Protocol . Robocalls can be delivered automatically using telephony software, e.g. using Asterisk call files.
SPIT Mitigation[edit]
RFC 5039 [1] contains some basic methods for the mitigation of telephone spam over SIP:
- White Lists and Black Lists
- Consent-Based Communications
- Reputation Systems
- Address Obfuscation and Limited-Use Addresses
- Turing Tests, Captchas, Computational Puzzles
- Payment
- Legal actions
A strong identification of the caller, for example as described in RFC 4474 [3] helps to mitigate SPIT. In a Public switched telephone network (PSTN), the Caller ID permits caller identification, but at least the displayed caller ID can be spoofed.
Various SPIT mitigation methods and frameworks have been proposed. A comprehensive survey of Voice over IP Security Research [1] (Chapter IV b) provides an overview. Many proposals focus on the reputation and the behavior of callers. A statistical analysis of the signaling traffic and in particular the call frequency can be used to detect anomalies, to observe and finally to black-list suspicious callers.[4] A Voice Spam Detector (VSD)[5] is a multi-stage spam filter based on trust and reputation. The SPIDER project [2] proposes a SPIT mitigation architecture,[6] which uses a detection layer consisting of various modules and a decision layer. The VoIP SEAL system [7] uses different stages. After a signaling analysis in the first stage, the suspicious callers are subjected to tests (e.g. Audio-CAPTCHAs) and the callee is asked for feedback in later stages. SymRank[8] adapts of the PageRank algorithm and computes the reputation of subscribers based on both incoming and outgoing calls. Furthermore, outliers in total talk duration and in repetitive and reciprocal calls can be used to detect suspicious callers.[8]
SPIT detection and mitigation can also be based on the caller's audio data.[9][10] This approach uses audio identification techniques (similar to music identification) to detect calls with identical audio data including certain degradations (e.g., noise and different audio codecs). A robust Acoustic fingerprint is derived from spectral parameters of the audio data and replayed calls are identified by a comparison of fingerprints.[11] A prototype solution has been developed within the VIAT project.
Researchers Azad and Morla (2013) conducted a study on detecting spam callers in a much accurate and secure approach. They invented a new scheme to detect spam calls without user interaction and prior reviewing the content of the message. The statistics from the several experiments showed this new system effectively detected spammers calling legitimate users without accessing the private information and user interaction.[12]
Implementation of Mitigation Measures[edit]
There is little information available on implementations of SPIT mitigation measures by Telephone companies. SPIT is generally not yet considered to be problem with similar relevance as E-mail spam. An automated analysis of the call signaling flow can help to discover SPIT. Commercial VoIP software for communication service providers may include a behavioral analysis, e.g. Acme Packet Palladion. Relevant parameters and indications of SPIT are, for example, a high call attempt frequency, concurrent calls, low call completion and low call duration average.
- ^ a b "The Session Initiation Protocol (SIP) and Spam (RFC 5039)". Internet Engineering Task Force. Retrieved 14 October 2012.
- ^ "SIP: Session Initiation Protocol (RFC 3261)". Internet Engineering Task Force. Retrieved 12 July 2010.
- ^ "Enhancements for Authenticated Identity Management in the Session Initiation Protocol (SIP) (RFC 4474)". Internet Engineering Task Force. Retrieved 14 October 2012.
- ^ D. Shin, J. Ahn, and C. Shim, Progressive Multi Gray-Leveling: A Voice Spam Protection Algorithm, IEEE Network, vol. 20, pp. 18–24, 2006.
- ^ R. Dantu and P. Kolan, Detecting Spam in VoIP Networks, in Proceedings of the USENIX Workshop on Steps to Reducing Unwanted Traffic on the Internet (SRUTI), pp. 31–37, July 2005.
- ^ Y. Rebahi, S. Dritsas, T. Golubenco, B. Pannier, and J. F. Juell, A Conceptual Architecture for SPIT Mitigation in SIP Handbook: Services, Technologies, and Security of Session Initiation Protocol, S. A. Ahson and M.Ilyas, Eds., CRCPress, Inc., 2009, ch. 23, pp. 563–582.
- ^ J. Seedorf, N. d'Heureuse, S. Niccolini, and T. Ewald, VoIP SEAL: A Research Prototype for Protecting Voice-over-IP Networks and Users, in Konferenzband der 4. Jahrestagung des Fachbereichs Sicherheit der Gesellschaft fu ̈r Informatik e.V.(GI), A. Alkassar and J. Siekmann, Eds., 2008.
- ^ a b H. K. Bokharaei, A. Sahraei, Y. Ganjali, R. Keralapura, and A. Nucci, You can SPIT, but you can't hide: Spammer identification in telephony networks, 2011 Proceedings IEEE INFOCOM, pp. 41–45, 2011.
- ^ Y. Rebahi, S. Ehlert, and A. Bergmann, A SPIT detection mechanism based on audio analysis, in Proceedings of 4th International Mobile Multimedia Communications Conference MobiMedia 2008: July 7–8, 2008, Oulu, Finland. ICST; ACM, 2008.
- ^ D. Lentzen, G. Grutzek, H. Knospe, and C. Pörschmann, Content-based Detection and Prevention of Spam over IP Telephony - System Design, Prototype and First Results, IEEE International Communications Conference (ICC) 2011.
- ^ G. Grutzek, J. Strobl, B. Mainka, F. Kurth, C. Pörschmann, and H. Knospe, Perceptual Hashing for the Identification of Telephone Speech, Speech Communication; 10. ITG Symposium; Proceedings of , vol., no., pp.1-4, 26-28 Sept. 2012.
- ^ Azad, A. M., Morlla, R. (2013). Caller-REP:Detecting unwanted calls with caller social strength. Computers & Security, 39(Part B), 219-236. do:10.1016/j.cose.2013.07.006

subset: commoncrawl


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Dead Space 3
Posted Jan 20, 2013 - 4:55 PM
Cover art depicting series protagonist Isaac Clarke
Developer(s) Visceral Games
Publisher(s) Electronic Arts
Composer(s) Jason Graves, James Hannigan
Series Dead Space
Engine Visceral Engine
Platform(s) Microsoft Windows, PlayStation 3, Xbox 360
Release date(s) NA February 5, 2013
AU February 7, 2013
EU February 8, 2013[1]
Genre(s) Survival horror, third-person shooter
Mode(s) Single-player, co-op
Media/distribution Optical disc, download
Dead Space 3 pits player character Isaac Clarke against the Necromorphs, human corpses reanimated by the signal of a Marker. To fight back, players must "strategic[ally] dismember" the Necromorphs' to kill them, using a variety of weapons to do so.[4] The Resource Integration Gear (RIG) suit also returns, using holographic displays projected from the players' suit and weapons to display health and ammo count, respectively. In vacuum areas (e.g. outer space), a timer will appear on the player's right shoulder, indicating how much oxygen that character has left before they suffocate.
In Dead Space 3, Isaac and newcomer Sergeant John Carver can roll and take cover to avoid attacks. This new ability was described by a Visceral Games developer as essential, as it "felt dumb/terrible not to have it" and that they have been "making Isaac more responsive," as they "want the horror to come from the terrible things that happen in the game; not from the horror that something is moving slowly towards you and you can't shoot it because the game controls like a piece of crap."[citation needed] The cover system is also described as "organic" in nature; for example, the player does not need to "walk up to certain tagged things and press the cover button; Isaac or Carver just does the action that is appropriate for the given situation."[5]
Co-operative gameplay
Dead Space 3 has a drop-in/drop-out co-op mode for its campaign, which was announced at EA's E3 2012 press conference, stating that it will unlock "additional story details and gameplay mechanics only found when playing as the co-op character, EarthGov Sergeant John Carver."[6] Each player will have alternate experiences as a result of their characters' dementia. For example, the player controlling Carver will find toy soldiers in a biology facility, while the player controlling Isaac will not see them. Co-op also puts the players in separate situations: for example, when Carver tries to open a door, he suddenly becomes trapped in his own mind (echoing a similar situation in Dead Space 2,[7]) forcing Isaac to protect him from a sudden surge of Necromorphs until Carver can free himself.[8]
A Visceral Games employee has confirmed it was "always intended to have co-op in Dead Space", citing co-op supporting game System Shock 2 as a source of inspiration for the Dead Space series.[citation needed] He also pointed out that if the player chooses to play alone, Carver "may appear at some points (as do other NPCs) but for the most part he is not there."[5][9][10]
Weapons Bench
The Bench weapon upgrade system from Dead Space and Dead Space 2 has been redesigned as a new upgrading system called the 'Weapons Bench'. Here, players are able to construct new weapons from parts gathered throughout the game. The Bench provides two main frames to start with—a light one-hand frame and a heavy two-hand frame—and players can build new weapons and even put two weapons together (for example, a Plasma Cutter and a Flamethrower). Examples of weapon functions include an electric rivet gun and an incendiary buzzsaw launcher.[11] If a player does not want to build a weapon from scratch, they can choose from ready-made blueprints, including classic Dead Space and Dead Space 2 weapons. Built weapons can also be shared in co-op mode.[12]
Two months after escaping the Sprawl,[citation needed] Isaac Clarke and Ellie Langford encounter Sgt. John Carver, a survivor of a Necromorph incident on the planet Uxor;[citation needed][13] and discover Tau Volantis,[14] a frozen planet where the ruins of another planetcracker ship are found.[4] Realizing that these miners had found the "source" of the Markers, the group tries to land on the frigid planet; however, the ship breaks apart upon entry, and Ellie is separated from the others.[9][15] As a result, Isaac resolves to save her along with his original goal of stopping the Markers. Many of the obstacles the two must face include a new human enemy, Unitologist soldiers; environmental hazards like falling machinery and a giant mining drill; and new variants of Necromorph, like the giant insect-esque Nexus and the more deceptive Wasters.[2][16]
In September 2011, a video was posted via IGN suggesting that Dead Space 3 was in production, showing art in development for the game.[17] Visceral Games had also leaked some information about the game including the setting and story.[18] On May 7, 2012, it was announced that a new Dead Space title was being developed for release by March 2013.[19] Game Informer unveiled a new image from Dead Space 3 showing Isaac wearing a fur-covered snow suit somewhere on Tau Volantis. The game was shown at E3 2012 and is set to be released in February 2013.[20]
The Limited Edition will come with two bonus suits (Witness and First Contact) and weapons (Evangelizer and Negotiator) for protagonist Isaac. Gamestop pre-orders will include the EG-900 SMG, a compact Earthgov submachine gun sporting an internal hyper-accelerator.[21] The PC edition of the game will only be available through EA's Origin service - It can still be purchased at retail, but must be linked to an Origin account. There are currently no plans to release the game on Steam.[citation needed]
A playable demo is due to be released on January 22, 2013 on on Xbox Live and the PlayStation Network. Xbox 360 owners who signed up on the official Dead Space website (Origin account required) were able to access the demo one week early.[22]
E3 reception
EA President Frank Gibeau responded by saying they "definitely do not want to piss off [their] fans" by toning down the horror content in Dead Space 3. "We tried to open up the accessibility of the IP a little bit by adding a little bit more action, but not undermining the horror."[23]
Posted Jan 20, 2013 - 9:20 PM
I....think people know what DeadSpace is dud, anyway I can't wait for it.
My YouTube for all your Blade & Soul needs! AppleBerryKitty
Posted Jan 21, 2013 - 6:13 AM
buying on the 1st day
Facts about forum...
Someone will correct you over a trivial grammatical error,and it's usually because they're not intelligent enough to actually come up with a smart argument.
All the class are overpowered except the one you using.
geez its just a game have fun man...
Someone will correct you over a trivial grammatical error,and it's usually because they're not intelligent enough to actually come up with a smart argument.
All the class are overpowered except the one you using.
geez its just a game have fun man...
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Zija News
New Markets & Languages
Zija's new and improved Website 2.0 is now available for the following markets and languages:
- Europe (English)
- Europe (Italian)
- Europe (French)
- Europe (Spanish)
- Australia (English)
- Australia (Korean)
- China (English)
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- Taiwan (English)
- Taiwan (Chinese Traditional)
- Malaysia (English)
- Malaysia (Chinese Simplified)
- Malaysia (Malay)
- Singapore (English)
- Singapore (Chinese Simplified)
- Thailand (Thai)
This is in addition to the current markets and languages that were already available:
- United States (English)
- United States (Spanish)
- Canada (English)
- Canada (French)
- Mexico (Spanish)
- Japan (Japanese)
- China (Chinese Simplified)
Each market and language's site will include only the products, promotions, and information that pertain to them. To access these new sites, click on the market and language box on the top right hand corner of this website. This will be a valuable tool as you expand your network and take your business global!


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Pay for Short-Term Performance: Executive Compensation in Speculative Markets
Patrick Bolton
Columbia Business School - Department of Economics; Centre for Economic Policy Research (CEPR); National Bureau of Economic Research (NBER); European Corporate Governance Institute (ECGI)
Jose A. Scheinkman
Columbia University; Princeton University - Department of Economics; National Bureau of Economic Research (NBER)
Wei Xiong
Princeton University - Department of Economics; National Bureau of Economic Research (NBER)
March 2006
NBER Working Paper No. w12107
We argue that the root cause behind the recent corporate scandals associated with CEO pay is the technology bubble of the latter half of the 1990s. Far from rejecting the optimal incentive contracting theory of executive compensation, the recent evidence on executive pay can be reconciled with classical agency theory once one expands the framework to allow for speculative stock markets.
Number of Pages in PDF File: 28
Date posted: May 15, 2006
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Call our experts: 888.808.FINE
Free printed return address printing on Checkerboard's Rosh Hashanah greeting cards It is that time of year for Prost! Host an Oktoberfest celebration!
Select a quantity and printing method. Changes are easily made later.
This elegant white photo album comes in soft French calfskin leather. Each album includes 18 clear polypropylene pages that hold 72, horizontal 4" x 6" photos. Add your personalized text for an added touch of elegance.


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so thanks again to everyone who made it out. what a weekend!
first, i want to wish our dear friend Chris "Conrad" the best of luck on his journey to actually..."live the dream!" he WILL be home soon, but will be greatly missed untill then. love ya brother!
next, of course, the man, the greatest, the one and only, king of hornings hideout... BOB HORNING! thank you Bob!
support Bobs senate bid at bobhorning.com
all our winners: Chris Graham, Mark Lawrence, Tim Stone, Lil Danny B, Krissy Reed and Jousha Donald Pitt the big fat pile of......love!
long drive winner: Chris Conrad
putting winner: trozzle
the two birthday boys: Crazy Mike and Big AL.
DGOD Admin: Andy V, Zac Conway and DGOD Arnie for all there hard work. couldnt have done it without you. thank you
Nick "young gun" Johnson for the sweet DGOD! cakes and all he does for my boys. nick was the only one there when lil dan got hit by the disc and he handled it like a F'n pro. thank you nick, for everything!
Emma Rose who played against all the boys and held her own... like we knew she would! thanks Emma
and to Ken Gilmore for being such a good sport and even autograghing a 2007 RCO dvd, thanks Ken!
thanks to my two boys who are the reason i do this!( i guess i kind of like it too) and my dear wife who lets me do it.
all our event sponsors: Gateway Disc Sports(DGOD! dosent follow trends, we set them... so get some Gateway in your bag!), Stumptown Disc Golf and Gwillim, Camp Dakota, Disc-Van-Go, cross the line outdoor adventure, NVS Glass, Jimmys Sports Bar, Sterling Savings Bank And Dekek "Nad" Nadvornick, Rick Jones at Disc golf creations and larren Gigliari.
in the end we raised $700 for Bob, and had a great time doing it!
stay tuned for our next events... lunchtime clean up #2 and happy holidaze #1 more info coming soon.
i love you all!!
event photos here... http://www.discgolfscene.com/profile/4708 ...we love comments!


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To celebrate the launch of The Show Must Go On, our friends at the Royal Opera House and EMI Classics have put their heads together to create a Show VIP Package Prize. The winner will receive two tickets to an end-of-year show at The Royal Opera House, a backstage VIP tour and 'A Festival of Ballet' collection of 50 CDs from EMI Classics, featuring music from Swan Lake and The Nutcracker.
The competition will take place on Twitter – you'll find us @showgametweets. All we ask is that you send us your crazy tales of your show experiences. Whether it's that time you had to deliver dentures to Someone Quite Famous' dressing room during a work experience stint or the evening you watched Peter Pan fly into the audience and hover there while stage crew scrambled to keep the show on track- we want to hear them! The best #showtales will be collated and we'll be very picky about our winner… the biggest challenge of all? Making us laugh with an anecdote of just 140 characters.


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Vertex Tile Effect Conservatory RoofThe Vertex tile effect conservatory roof is a fantastic product in any portfolio. It is perfect for homeowners who want the benefits of a traditional extension without the associated cost or upheaval. And because it can be retro-fitted, it is also perfect for homeowners struggling with a conservatory that's too difficult to heat or impossible to keep cool. It truly helps to make a conservatory a room for all seasons and eliminates the need to retrofit blinds or heating or cooling systems.
The Vertex roof offers improved insulation and thermal efficiency while at the same time keeping the traditional rafter interior finish requiring no extra plastering.
Here's what one homeowner had to say about the Vertex tile effect roof...
We had lived with a polycarbonate roof on our existing conservatory in full sun for many years with the standard complaints of too cold in the winter and too hot in the summer. We eventually decided that we could get more use from the space if we could overcome these problems and so, after much internet research, arrived at the Vertex tile effect roof.
More deatils available on request.


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Ok, I'll admit it. He is a fine kick at goal. He is an incredible kick at goal. At 196cm and just over 100kg, the man has kicked 42 goals in just 8 games. Lance "Buddy" Franklin is the man I am referring to. However, I will not call him Buddy in this post or any other – not due to jealousy of this prodigy being a Hawk, but simply out of protest.
Where the nickname 'Buddy' originated, I have no clue. I have a strong sense it is of inter-club birth, though. This is a name his team mates and possibly friends outside of football christened him with. There would be a deeper meaning to the name but I am not here to talk about that. What I will talk about is the frequent, almost gratuitous over-use of the nickname. Not by you and me. Not by fans. Not by teammates. But by the media. Every newspaper that has any interest in AFL will repeatedly refer to him simply as Buddy. Radio personalities, TV hosts and commentators all refer to this goalkicking phenomenon as "Buddy".
Call me sour but I have always been quite irked by the use of nicknames, and even first names by commentators calling the play. It has happened in a number of circumstances in different sports. From cricket in which commentators – namely Ian Chappell – referred to South African super-fielder Jonty Rhodes as just "Jonty". Also, in rugby league, all that was heard north of the Murray for the better part of 10 years was "Andrew" or even worse, "Joey", to decribe Andrew Johns. During State of Origin games, Grand Finals, Test Matches…Joey, Joey, Joey! It grew to the stage where people just about forgot the man's surname. And I am afraid the same is happening to Lance Franklin. Who? Lance?
I could use any number of references but I will refer to the game against Collingwood in round 7. At one stage late in the 63 point thumping, Franklin broke into a grin. I'm not entirely sure what enticed this random smile, but boy were the Channel 7 commentary team happy about it!
"Isn't it great to see Buddy and this whole Hawthorn team smiling!" Those were their words. Sickening. Absolutely sickening. Now watching this game and happening to support a team other than Hawthorn, I believe I stand for most when I say I was embarrassed by the complete bias in this statement. Not just towards our friend Lance, but also the Hawthorn team. In saying that they were happy to see them smiling, it sounded as if they had just wandered into the MCG after 40 long days in the desert. As if the Hawthorn reference was bad enough, the mention of "Buddy" made me grind my teeth to the point where they were just about falling out.
Now I may very well be a raging traditionalist sour-puss. But I believe that if Gary Ablett can be called "Ablett", and Nathan Buckley "Buckley" and Wayne Schimmelbusch "Schimmelbusch", then Lance Franklin must be called Lance Franklin.
Yes, call him a legend. Call him a phenomenon. A prodigy. Call him all of those things. But please, please stop calling him "Buddy"!


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Stars come to GJ to support Obama campaign
Posted: 10/25/2012 - Amy Brenneman and Jon Hamm are among the stars helping out on the campaign trail.
Posted: 10/25/2012 - Amy Brenneman and Jon Hamm are among the stars helping out on the campaign trail.
Posted: 10/23/2012 - President Obama and Mitt Romney are opening a two-week sprint to Election Day powered by adrenaline.
Posted: 10/23/2012 - Republicans claim that Democrats wrongly offered college students free pizza and T-shirts in exchange for voting.
Updated: 10/23/2012 - Vice Presidential candidate Paul Ryan made a stop in Grand Junction on Monday, speaking to a packed house at CMU's Brownson Arena.
Updated: 10/23/2012 - See pictures from Paul Ryan's visit to Grand Junction.
Updated: 10/23/2012 - Voters make decisions and cast their ballots prior to final debates.
Posted: 10/22/2012 - Republican group gathers to make signs for Vice Presidential Nominee Paul Ryan
Updated: 10/23/2012 - Paul Ryan will swing through Colorado today, stopping at CMU tonight for a Debate Watch Party.
Posted: 10/18/2012 - For the Mesa County Republicans, it all comes down to the balance of power in the state house.
Posted: 10/16/2012 - Bill Clinton and Paul Ryan continue on the campaign trail.
Posted: 10/11/2012 - Both sought to distance themselves from their parties.
Posted: 10/11/2012 - Forty percent of registered voters say Ryan will outperform Biden, while 34 percent expect Vice President Biden to do better.
Updated: 09/19/2012 - A new poll has Obama's approval rating at 52 percent among all adults, and just 37 percent for Romney.
Posted: 09/08/2012 - Barack Obama and Mitt Romney will have it out in their first debate hoping to gain more votes.
Posted: 09/06/2012 - Paul Ryan was last in Colo. on Aug. 14, when he stopped in Jefferson County.
Updated: 08/30/2012 - The measure did not get enough signatures to put it on the ballot.
Updated: 08/29/2012 - KKCO 11 News anchor Glen Mills interviews Josh, who is in Tampa.
Posted: 08/29/2012 - The New Jersey governor says tough choices are ahead.
Posted: 08/29/2012 - The president visited CSU on Tuesday and will return to Boulder Sunday.
Updated: 08/25/2012 - The Republican Party is delaying the bulk of its convention until Tuesday afternoon because of the severe weather expected from Tropical Storm Isaac.
Posted: 08/22/2012 - President Barack Obama is returning to Colorado next week to try to steal the spotlight from the Republican National Convention.
Posted: 08/20/2012 - Missouri Republican congressman Todd Akin is apologizing for his televised comments in which he said women's bodies are able to prevent pregnancies if they are victims of a "legitimate rape."
Posted: 08/14/2012 - A new report says President Barack Obama has an advantage over Republican Mitt Romney when it comes to reaching voters online.
Posted: 08/14/2012 - Hundreds of people are trickling into the gymnasium at Lakewood High School to see Mitt Romney's running mate make his public debut in Colorado.
Posted: 08/09/2012 - President Obama is wrapping up his swing across Colorado with tough attacks on challenger Mitt Romney.


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All new tonight an Eastover home hit twice in as many weeks by brazen burglars. We're talking to the house-sitter shot in the first crime. Then overnight, burglars ransacked the place again.
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Snapfinger Food Ordering App Hits Android
- Mar 25, 2010 7:46 PM EST
- [num] Comments
Snapfinger has unveiled an Android version of its food ordering mobile app, which joins the company's existing iPhone version.
The new Android app lets users order food from over 28,000 restaurant locations in 1,600 cities across the United States. The app searches for nearby locations, places food orders, and completes payment transactions that are synchronized with each restaurant's POS (Point-Of-Sale system; shush, it's not what you're thinking).
It also features real-time menu updates, gives estimates of prep and delivery times, and delivers order confirmations via text or e-mail. Snapfinger says the company currently processes over 50,000 transactions each weekend, and sees as many as 1,600 downloads on any given day.


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Response to the availability of health insurance coverage under the federal Affordable Care Act, in understatement, has been less than overwhelming in Mississippi. As of late November, only 148 Mississippians had been registered.
A free information time on Saturday at the Link Centre drew only nine people to get the information offered by Catch Kids and Access Family Health Services.
The ACA's website dysfunction has been its own worst enemy nationwide, but the White House announced Saturday the site now can handle up to 50,000 people at a time, which, if correct, should increase registrations.
The clock is running on the deadlines set for the required registration for health insurance coverage; the first month's premium is due by Dec. 23 so that the insurance can be in force by Jan. 1, 2014. However, enrollment does not close until March 31; after that date, late enrollment penalties will apply unless rules are changed.
An online application, however, is just one of four ways to go through the registration process.
The official website, HealthCare.gov, offers explanations on how to register:
• Apply with a paper application; fill out a paper application and mail it in, and also find out "whether you're eligible for lower costs on private insurance, Medicaid, or the Children's Health Insurance Program (CHIP). To get a paper application, download the application form from the website.
• Apply online:
Set up an account. Start by going to the Marketplace page. First you'll provide some basic information.
Compare options. You'll be able to see all the options you qualify for, including private insurance plans and free and low-cost coverage through Medicaid and the Children's Health Insurance Program (CHIP).
Enroll, and after you choose a plan, "you can enroll online and decide how you pay your premiums to your insurance company. You must pay your premium by the date the insurer provides before your coverage can begin. Coverage can begin as soon as Jan. 1, 2014.
Learn what you can do to get ready to enroll.
• Apply by phone or with an in-person assister:
Call (800) 318-2596, 24 hours a day, seven days a week (TTY: 1-855-889-4325). A customer service representative will assist, or call Catch Kids at (662) 377-2194 or Access Family Health at (662) 844-4252.
All people must have health insurance unless the law is repealed, and that seems unlikely.


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Our Mission
Business and Technology Advisors
Support Services
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Orbis Voice
Produce Logic
Case Studies
T.M. Kovacevich Philadelphia, Inc. is a distributor of fresh produce, specializing in premium fruits, located in the Philadelphia Regional Produce Market.
Since 2004, TMK has been using ProduceLogic Professional, a complete solution developed specifically for the produce wholesaler. ProduceLogic Professional uses the latest technology, from touch screen point-of-sale kiosks to biometric security features.
While the software was involved in nearly every aspect of TMK's complex operations, from order entry to receiving inventory to order fulfillment and billing, the interface was designed to be as simple and intuitive as possible. This allowed salespeople and warehouse workers who had never used computers in their day-to-day work before to quickly and easily learn the new system. Touchscreen monitors were utilized for ease of use. High speed thermal printers allowed for fast, automated printing of sales tickets and pallet stickers. Custom reports were created to provide real-time data at the click of a button. Orbis even designed and built sales kiosks customized for TMK's location.
ProduceLogic also includes a full accounts payable and receivable module. A wireless Ethernet bridge was installed to allow TMK's back office operations to seamlessly connect to the warehouse located across the street and use these features.
With the help of Orbis, TMK was able to advance their operation from handwritten tickets and delayed sales and inventory figures to point-of-sale order entry and real-time inventory.


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NEW DELHI: Trinamool Congress chief Mamata Banerjee on Wednesday said that Pranab Mukherjee was the first choice of Congress President Sonia Gandhi as the Presidential candidate. She made the statement after meeting Sonia Gandhi in New Delhi.
Hamid Ansari is the second choice of Sonia Gandhi, Mamata Banerjee told reporters. She however did not comment on the candidate the Trinamool Congress would support. This puts to end weeks of speculation regarding the Congress' choice for the Presidential canditate.


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What are natural fibers made from? What is a Natural Fiber?
NATURAL FABERS are created from fibers of animals coats, silkworm cocoons, and plants´ seeds, leaves, and stems. Click on the natural fiber below for information on each fiber and their weaves.
Wool - Fibers from animal coats: Sheep, goats, rabbits, alpacas, llama, etc. Cotton - Fibers from the cotton plant´s seed pod. Silk - Fibers from the cocoon of the silkworm. Linen - Linen is from flax, a bast fiber taken from the stalk of the plant. Hemp, Ramie, and Jute - All of these are similar to linen but the plants are processed slightly differently.
Other commonly asked questions about Fabrics and their Features
- What is Micro Suede?
- What is TWO-FOLD or Two ply Cloth?
- What is Dormieul?
- What is Super 100s, 110s, 120s, 130s, 150s, and 180s?
- what is the designer brand Collections?
- What is SEERSUCKER?
- What is ply?
- What is yarn size?
- What is thread count?
- What is a Burn Test? How do I test a fabric?
- What is manufactured – Man Made Fabrics and kinds of manufactured fiber?
- What is hemp fiber and jute?
- What are weaves and how are they different from fabrics?
- What is cotton? What are its uses?
- What is wool? What are the different kinds of wool and their advantages?
- What kind of cloth is linen and of what kind of material is linen composed of?
- What is Glen Plaid?
- What is vicuna wool?
I have a question about another topic.
I have a different question about Fabrics and their Features (Send an Email)


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Maps of Vellore
Please use the + or - buttons to zoom in or out. Try the "Hybrid" view for an interesting view!
View CMC Vellore in a larger map
Vellore is in Tamil Nadu state in southern India, about 140 km (almost 90 miles) inland from Chennai (Madras). It had a population of over 177,000 in the 2001 census.
So ... Where exactly is Vellore?
|Pictures from Flickr tagged "Vellore". Click to start slideshow.
CMC Rocks
|The Christian Medical College song begins "Girded 'round by her strong ageless mountains", and this satellite image shows the ancient rock of the Deccan plateau. The riverbed remains dry for most of the year, apart from the monsoon season.


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Such a cute blog with lots of great pictures.
I left you a comment and subscribed via email. Please come by and visit and follow as well.
Hi all! I've been blogging for a few years now, but new to Mom Bloggers Club, and have recently made the decision to try to grow my little blog to open up more opportunities for occasional reviews, etc. My blog, A Modern Day Fairy Tale, is an eclectic mix of everything that makes up my life. From being a Marine Corps wife, to raising a child with Autism, to now having baby # 2 coming in August 2013...I talk about it all, and more! Would greatly appreciate any new readers and followers!
I'll be going through and trying to follow some of your lovely blogs too!! Thanks so much!
Welcome Randi! If you're looking for a way to grow your blog and open it up, this is the place to do it! I have met such great people here and am following so many amazing blogs now that I feel like I should stop writing my own and just spend my days reading everyone else's!
Congrats on the new baby. Looking forward to checking out your blog tonight- after the little ones are down;)
twitter: @PursuitOfNormal
Welcome Randi! I'm following your blog and can't wait to read more! :)
Check out my blog for great parenting advice, educational info and more!
I am a mom to 10 kiddos, living a super sized life follow me as I share my journey as a mom, writer, and home educator http://www.mamajil.com
I think you are going to have the best advice and the best stories to share! Looking forward to checking you out!
twitter: @PursuitOfNormal
Hi, I am following your blog! I am very excited to read your posts! Would love for you to come check out my blog which is still very new at http://simplyathomemom.com/
I have some EXCITING NEWS! Come see over on the blog!
(No, I'm not pregnant.:)
twitter: @PursuitOfNormal
Hi! I'm Keisha! Stop by my blog, I'm looking for new followers and I always follow back! :)
You can also find me on
twitter: https://twitter.com/bkissesoflove
facebook: https://www.facebook.com/butterflykissesoflove
and instagram: @bkissesoflove
Thank you!


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The members were elected in October 2013 and will remain in office for 3 years.
Contact the mayor or your councillor
Information about the 9 council committees
Monthly meeting calendar including agendas, reports and minutes
Council's long term plan
The agreed understandings and expectations of elected members
Information about speaking at a meeting
Local governance statement, standing orders
Civic awards reward our district's greatest helpers.
To be held by postal vote on Saturday 8 October 2016
For Gisborne ward will be held on Thursday 3 July 2014
12 October 2013


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SPRINGFIELD - Walter Kinnard "Kin" Dillon, 82, formerly of Morehouse and Cape Girardeau, died Dec. 4, 2002, at Cox South Hospital in Springfield.
Born Aug. 17, 1920, in Morehouse, son of William H. and Melissa B. Kinnard Dillon, he attended Morehouse Grade School, Sikeston High School, Southeast Missouri State University and Parks Air College. He served in the 8th and 9th Air Forces in England and Germany during World War II and had attained the rank of base sergeant major. Dillon served with the 10th Air Force during the Korean War. An active Republican, he was the party's nominee for Congress for the 10th Congressional District in 1946 and 1948. He operated the Dillon Theatre and Dillon Insurance Agency in Morehouse. Dillon relocated to Cape Girardeau, where he was an independent insurance adjuster for many years. He became managing officer of Cape Carriage Company and Cape Motor Company and then became an insurance claims consultant for Cameron Insurance Company, from where he retired.
A member of Centenary United Methodist Church in Cape Girardeau, he was a long time member of the SEMO Regional Port Authority Board of Directors in Scott City, for which he was chairman in 1997 and 1998 and was also a member of Sikeston Lodge 310 AF&AM Scottish Rite, Capaha Scottish Rite, Moolah Shrine Temple and the Cape Shrine Club.
On July 5, 1952, he married Dorothy Faust Jones who survives of the home.
Other survivors include: one son and daughter-in-law, Michael A. and Gloria Jones of Springfield; one son, Stephen R. Jones of Florissant; one sister, Frankie Mae Woods of Merced, Calif.; one sister and brother-in-law, Shirley and Douglas Hammock of Morehouse; a sister-in-law, Juanita Dillon of Morehouse, and three grandsons and a granddaughter-in-law, Matt and Beverly Jones of Lees Summit, Brett Jones of Kansas City and Scott Jones of St. Louis.
Two brothers and one sister preceded him in death.
Services were conducted at 2 p.m. today at the Centenary United Methodist Church with Dr. Clayton Smith, officiating.
Burial followed in Cape County Memorial Park.
Members of the Cape Shrine Club served as pallbearers.
Memorial contributions may be sent to:
St. Louis Shriners Hospital 2001 S. Lindbergh Blvd. St. Louis, Mo. 63131-3597
Centenary United Methodist Church 3001 N. Ellis St. Cape Girardeau, Mo. 63701
Paid obituary


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First) If you weren't there you can't really give a quality review one way or the other.
Second) If you've been to Portsmouth, like I have last night and last year too, and am at currently waiting for the tonight's show to start, then you'd know that it's general admission and you can pretty much get to the front no problem. Easy access all the time - such an awesome venue.
For Example, check out this video I took while walking down to the front about 30 minutes into the first set.
Anyways, I agree with you that the show was rad.


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Agency Information Collection Activities; Announcement of OMB Approval; Administrative Detention and Banned Medical Devices
The Food and Drug Administration (FDA) is announcing that a collection of information entitled "Administrative Detention and Banned Medical Devices" has been approved by the Office of Management and Budget (OMB) under the Paperwork Reduction Act of 1995.
Table of Contents Back to Top
FOR FURTHER INFORMATION CONTACT: Back to Top
Peggy Schlosburg, Office of Information Resources Management (HFA-250), Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, 301-827-1223.
SUPPLEMENTARY INFORMATION: Back to Top
In the Federal Register of March 31, 2000 (65 FR 17282), the agency announced that the proposed information collection had been submitted to OMB for review and clearance under 44 U.S.C. 3507. An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB control number. OMB has now approved the information collection and has assigned OMB control number 0910-0114. The approval expires on August 31, 2003. A copy of the supporting statement for this information collection is available on the Internet at "http://www.fda.gov/ohrms/dockets".
Dated: September 12, 2000.
William K. Hubbard,
Senior Associate Commissioner for Policy, Planning, and Legislation.
[FR Doc. 00-24006 Filed 9-18-00; 8:45 am]


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SCHLADMING, Austria — Lindsey Vonn said Wednesday she will work hard in her bid to return to skiing from a severe knee injury for next year's Olympics in Sochi.
"I can assure you that I will work as hard as humanly possible to be ready to represent my country next year in Sochi," Vonn said via the United States ski team.
Vonn, 28, ruptured the cruciate ligament and medial collateral ligament in her right knee, and fractured the tibia head, in a crash during the world championship super-g on Tuesday.
Vonn said she will undergo surgery soon in Colorado before starting a long rehabilitation process. The Sochi Olympics start a year from today on Feb. 7, 2014.
Vonn won the downhill gold at the 2010 Games in Vancouver and is among the biggest names in skiing. She has four overall World Cup titles and 59 race wins for second place on the all-time list.
"I plan on returning to Vail as soon as I can to have the necessary surgeries. I am also grateful to my fans for the outpouring of support, which has really helped me stay positive," Vonn said.
Location, ST | website.com


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October Virtual Sketch Date
I have company coming this weekend, so I'm posting my painting for the October Virtual Sketch Date early. This is the first time I've used rough paper and I really like the granulation.
Sharon, I love the textured, gritty pear-essence you've captured!
Sharon this is just lovely
These are fresh and light, your usual deft touch.
I really like it how you overlapped the left pear with the middle one.
Very clean. Very sumi-e.
This truely is lovely. Bright, clean and straight forward. Did I say how great this is?
Super work, Sharon. I admire the neatly placed and natural looking dark spots... I tried the "controlled" splash, with rather messy results.Tips?
the texture in the piece is perfect, very nice indeed.
I always love watercolor paintings of pears, but yours are exquisite. Beautiful!
Simply beautiful, Sharon--the light, the colors, the shapes of the pears. Beautifully handled!
what a nice and bright group of pears!
Brilliant, Sharon! These are absolutely perfect!!!
These are beautiful! You're right -- the rough paper really works well with the subject.
Your painting look like pears taste - cool, crisp, clean. Wonderful job!!
So nice. Colors are great.
Really beautiful and transparent. Just lovely
Nice work! I like the way you changed the composition and overlapped those two pears.
Hi Sharon. Thanks for your comment on my blog, and for the clever and generous tip. Your use of the paint's granulation is so good, with the added effect just finishing it beautifully. After looking at lots of pears, your version comes up trumps! It's really great.
This leaps off the page, well, of my computer screen! I love it, you make it look effortless!
I've seen a lot of these pears by now, but these are in the very tip-top of the whole crop. Beautiful work!
Just beautiful, Sharon.
Very nice. I like the colors you got.
Wonderful colours and shape.
Gorgeous picture!
this is wonderful and so fresh!
wow! they look fabulous!
Wow, the paper was perfect for the subject matter.
Theses are very nice. Love the white spots too.
what paper did you use?
I used Arches 140 lb. rough for this, but I think I like Lanaquarelle rough watercolor paper better.
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Jus Jack Launches New Label with "Party People"
NYC based DJ/Producer and nightlife fixture Jus Jack is happy to announce the launch of his brand new label appropriately entitled Party People. Party People is a new label, party experience and radio show that debuted Friday, September 6th at Pacha NYC. Curated by Jus Jack, Party People will see releases and collaborations from Feenixpawl, David Tort, and Sunnery James & Ryan Marciano, in addition to original tracks by Dzeko & Torres, DBerrie and more.
After a summer filled release schedule including a remix out on Musical Freedom and a Dim Mak EP, Jus Jack's "Party People" is out today, marking the first release on the new label. The single is already receiving support from Kaskade, Michael Brun, Tiesto, Dirty South, Thomas Gold, Gareth Emery, Ferry Corsten, Morgan Page & more.


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Zelis Healthcare - from Network Solutions through Claims Integrity to Payments.
Results, performance, and expertise you can trust. Get a glimpse inside PHX and find out why our connections with our clients are the core of our success, it is our DNA.click here.
At PHX, we develop innovative solutions to help our clients with their challenges. Let us show you the range of our services and how we can help you with your business objectives.


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Definition of lily in English:
noun (plural lilies)
1A bulbous plant with large trumpet-shaped, typically fragrant, flowers on a tall, slender stem. Lilies have long been cultivated, some kinds being of symbolic importance and some used in perfumery.
- Genus Lilium, family Liliaceae (the lily family). This family includes many flowering bulbs, such as bluebells, hyacinths, and tulips. Several plants are often placed in different families, especially the Alliaceae (onions and their relatives), Aloaceae (aloes), and Amaryllidaceae (amaryllis, daffodils, jonquil), and as many as 38 families are sometimes recognized.
Example sentences
- Autumn is the time to put in bulbs for early spring including snow-drops, daffodils, crocuses, lilies and bluebells.
- This is also the time to plant lilies, tulips and alliums for spring colour.
- Nico and Jean will take us on a tour of their facilities showing us the expanse of daffodils, tulips, lilies and delphiniums.
1.1 short for water lily.
Example sentences
- A whole new world of gardening awaits you when you go searching for water lettuce, water hyacinths, lilies and prairie grass.
- Borland takes me on a tour of the back end of the distillery, where the waste water is filtered through reed beds full of bulrushes and lilies.
- We would play around the fountains, and if we had money to hire a boat from the boating club, go boating in the ponds navigating carefully through a crowd of lotuses and lilies.
1.2Used in names of other plants with flowers or leaves similar to those of the lily, e.g., arum lily.
Example sentences
- Rather brace yourself for bunches of fresh arum lilies, proteas, flame lilies and aloe leaves.
- Studies of seed germination, leaf development and the onset of thermogenesis during flowering in Arum lilies all provide evidence of mitochondrial heterogeneity.
- They gave the odd lilies the name of Maiden Lilies, for they had the same colorations of the pale skinned, blue haired, dark haired women of the village.
2A heraldic fleur-de-lis.
Example sentences
- 'The badge does indeed combine the silhouette of the Eiffel Tower with a cradle and the fleur de lis, or lily,' explains Tim Pike.
- Example sentences
- Don't let this San Francisco gay bar's funereal front, with its large and lilied flower arrangement, get you down.
- By lilied pools where the bull moose cools and wallows in huge content; By rocky lairs where the pig-eyed bears peered at our tiny tent.
Old English lilie, from Latin lilium, from Greek leirion.
Words that rhyme with lilyBillie, billy, Chile, chilli (US chili), chilly, Dili, dilly, filly, frilly, ghillie, gillie, Gilly, hilly, Lillee, Lyly, papillae, Philly, Piccadilly, piccalilli, silly, skilly, stilly, Tilly, willy-nilly
For editors and proofreaders
Syllabification: lil·y
Definition of lily in:
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SIKESTON -- Jimmie Lee Summers, 70, died at 6:09 p.m. Jan. 4, 2003, at St. Francis Medical Center in Cape Girardeau.
Born July 30, 1932, in Chaffee, son of the late Leo and Violet Gore Summers, he was a parts exchanger in the International Shoe Factory Maintenance Department in Sikeston and member of Christ Gospel Church in Blodgett.
On Dec. 29, 1954, in Holly Springs, Miss., he married Coy Mae Standridge who preceded him in death on May 28, 2001.
Survivors include: three daughters and sons-in-law, Linda Fay and Wayne Johnson of Sikeston, Brenda Kay and Jeff Bon'e of Dewy Rose, Ga., and Pamela and Jimmy Dodds of Sikeston; two sisters, Audrey Sterling of Mayfield, Ky., and Shirley Finney of Windfall, Ind.; and eight grandchildren and four great-grandchildren.
Visitation is from 5 to 8 p.m. Tuesday at Nunnelee Funeral Chapel, where services will be conducted at 10:30 a.m. Wednesday. The Rev. Joe Crawford, pastor of Christ Gospel Church, will officiate, assisted by Danny Rice.
Burial will follow in Garden of Memories Cemetery.
Pallbearers will be: Keith Standridge, Timmy Smiley, Eddie Summers, Jimmy Dodds Jr., Freddie Dodds and Jamie Sterling.


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LODI – Highway 12, one of the roads that connects the Valley to the Bay Area through the Delta, has reopened nearly four hours after a fatal collision closed the road in both directions.
According the California Highway Patrol, a big rig carrying household goods and a silver pickup struck head-on around 7:50 this morning, blocking traffic in both directions. At least one other car went off the road, according to the CHP traffic website.
Motorists on Highway 12 had been stopped in their cars for at least an hour this morning before they were turned around as dozens of emergency vehicles responded to the scene.
There is no word on the identity of the person killed.
Come back to www.recordnet.com and read Friday's Record for more on this story.
Location, ST | website.com


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rogerfederer.com - First title in 2008
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First title in 2008
Roger began his clay season with success as he won his first title of 2008 with a 7-6 (7-5), 1-2 victory as Nikolay Davydenko retired injured at the Estoril Open on Sunday. Our star improved his record against the world number four Russian to a perfect 12-0 as he won only their third encounter on clay.
"It's great to win a title, it's fantastic," said Roger. "This will give me great confidence for the rest of the season having won my first clay tournament of the year."
The victory was his seventh on the surface and was obtained in challenging, blustery conditions."These were the most difficult of the week," said the Swiss holder of 12 Grand Slam titles. "It was cold as well as windy. This is not the best way to win a match and I'm sorry for Nikolay. But sometimes these things happen."
I know its not the way you wanted to win, but the fact that you made it to the final gave you a fifty-fifty chance anyway. Gongrats.
Good luck at Monte Carlo. I know you can beat Nadal this time! LOVE YOU!
Bye for now.
thank you!!!You smile and make me smile too!!!Keep on
my love
4/21/08 1:54 PM | Mattias Yrgård
Pete Sampras figures it's only a matter of time before Roger Federer achieves what the American never could - lift a Roland Garros title.
Federer began his quest for the only m
More titles to come!
All the best wishes for the clay season and this week in Monte Carlo!
continua così .....forza Roger...!!!
You played great, just keep on going...
I love you!
Good luck!
I'm so happy, you were so cute...
I'm taking it your not a Djokovic fan! I agree with your comments but a lot of what comes out of his mouth is pre-meditated.
Its a form of gamesmanship that he feels he needs to employ to get one up one Roger. Tradgic really!!!
All the best in Monte Carlo.


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Polish death metallers VADER have commenced work on the material for their sixth full-length album, tentatively titled "Spiritual Disease", for a May/June release through Metal Blade Records. Among the tracks set to appear on the CD are "Out Of A Deep" and "Lead Us!"The follow-up to 2002's "Revelations" will be recorded in February 2004 at PR Studio in Gdañsk with producer Piotr Lukaszewski and will mark the group's final release for Metal Blade under the terms of their present contract with the label. In other news, PANZER X, the solo project of VADER vocalist/guitarist Peter, are in the middle of recording their promotional CD at Studio X in Olsztyn, Poland. Titled "Steel First", the CD will feature "four pieces plus two cover songs and something extra," according to a posting on VADER's web site. "Steel First" is being engineered by Szymon Czech and produced by Peter himself. Wojtek Blasiak, the artist who recently did some graphics work for MOONSPELL, will take care of the "Steel Fist" artwork and layout.
VADER: New Songtitles Revealed
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Saturday night, Willis was even more declarative about what he would have done.
"I would have shook his hand," he said. "I would have tried to stop him in the line and shake his hand."
To be sure, the stage was set Saturday night for the former Encinal High star native to go into the baseball record books with the man he put on a high personal pedestal while growing up in Alameda. Clearly, from a number of comments he has made about Bonds, he might not have minded as long as the Giants star earned it.
But actually go to home plate to offer congratulations?
Ah, we'll never know. Bonds went0-for-3 with a walk against Willis a strikeout and two popups. Willis left the game with a 3-2 lead, although the Marlins coughed it up in the ninth inning and lost 4-3.
But in a milestone irony, Willis actually got his 700th career strikeout against Bonds.
"Maybe he'll sign my ball, I don't know," he said with a grin.
Unless Bonds' quest for the all-time home run mark extends into mid-August, when the Giants travel to Florida for a four-game series, Willis is now off the hook for an all-time association with Barry. But again, while most pitchers might be frightened by the prospect of being Bonds' victim for either No.
"I'm a great fan, but he knows I'm a competitor," he said. "If he hit if off me, I would have been congratulating him and been a man and given him all the praise because he deserves it. It's amazing to see what he's done in the midst of all the adversity he's taken on and off the field."
Bonds befriended Willis early in his major-league career, and their friendship has grown through the years. Bonds couldn't suppress a grin when he stepped in for his first at-bat, but Willis was all business. After throwing a ball outside on the first pitch, he came back with three straight strikes, the last one a try-and-hit-me heater that he simply blew by Bonds.
In their second confrontation, in the third inning, Willis backed Bonds off the plate with a high inside fastball, then jammed him on the next pitch, and Bonds hit a meek popup off the first-base line to end a second-inning threat. The two appeared to exchange a little friendly trash talk as Bonds headed back to the dugout, heightening the drama for their succeeding confrontations.
"Just having fun," Willis said. "I respect him as a competitor, and he respects me as a competitor so we were just having fun out there. If it's going to happen, it's going to happen. You might as well enjoy it. You're in the presence of the greatness. I really appreciate what he's done for the community as well as myself, being an African American. Like I told my daughter, if he's done after this year, I can always say I competed against the best."
Bonds made a big impression on Willis long before they ever met.
"As cheesy as it sounds, it's true," he said. "We don't realize as athletes how we affect people's lives. My family was always big baseball fans for the Giants and the A's. It was not only critical to get home before that streetlight came on, but get home before the games started."
This game surely played well on TV sets throughout Alameda. Bonds and Willis would meet yet once more, with two on and two outs in the bottom of the seventh. Huge situation. Willis had already thrown 105 pitches, and Bonds was almost certainly to be his last batter. Somewhat surprisingly, the Giants slugger tried to jump on the first pitch, but he popped it straight up and high just behind home plate, and catcher Matt Treanor snared it.
Willis, frequently emotional and demonstrative after big outs, let it all hang out after retiring Bonds a final time, cutting loose with a roundhouse fist pump and an excited dance back to the dugout.
It made for some pretty swell theater, but in reality, it would have seriously bucked the odds had Bonds gone deep against Willis. Despite a spotty 2007 season to this point, Willis has been dominant against left-handed hitters, limiting them to a .133 average (11-for-83) and just two extra-base hits, neither a home run. By contrast, right-handers were hitting .331, with 16 home runs and 49 extra-base hits against Willis.
But on this night, he was strong against Giants hitters from both sides, allowing just six hits and one earned run over seven innings. Perhaps facing Bonds gave him that extra motivation and adrenaline rush to find his vintage form. One thing's for sure, he wasn't feeling fear about giving up No. 755.
"I'm not afraid of that," he said. "Maybe some people are, but I'm not afraid of that. I think I showed it, going out there and throwing my best stuff. Whatever happens, happens."
It didn't happen, and we may have missed something historic. A record home run, and the pitcher who gave it up offering his hand in congratulation.
Carl Steward can be reached at
(510) 293-2451 or by e-mail at


text:
Issue No.03 - May/June (2005 vol.25)
pp: 58-69
Tilak Agerwala , IBM Research
Siddhartha Chatterjee , IBM Research
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/MM.2005.45
In an updated version of Agerwala's July 2004 keynote address at the International Symposium on Computer Architecture, the authors urge the computer architecture community to devise innovative ways of delivering continuing improvement in system performance and price-performance, while simultaneously solving the power problem.
Computer architecture, system performance, application, workloads, power-aware architecture, accelerators, scale-out, system-level power management
Tilak Agerwala, Siddhartha Chatterjee, "Computer Architecture: Challenges and Opportunities for the Next Decade", IEEE Micro, vol.25, no. 3, pp. 58-69, May/June 2005, doi:10.1109/MM.2005.45


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Arkansas: Corn and Grain Sorghum Producer Conference, Jan. 8, 10
The Fifth Annual Corn and Grain Sorghum Producer Conference, sponsored by the Arkansas Corn and Grain Sorghum Board, will be offering attendees a choice this year. There will be two conferences, one located at the ASU Alumni Center in Jonesboro on January 8, the other at the Dumas Community Center in Dumas on January 10.
The content will be repeated at both conferences, so there is no need to attend both.
Registration will begin at 8:30 A.M. the day of the conference, with the conferences taking places from 9 A.M. to 1 P.M.
For more information or to inquire about booth space, contact Matt King, email@example.com.
AgFax Weekend 8-29 Retailer Margins Tighter; Mycogen's New Pricing Plan
This week's news in agriculture from Agfax Media.


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Changing and Cloakroom Storage
Cloakroom storage is catered for from our attractive and robust range of cloakroom equipment and changing room furniture. Available in a variety of frame colour options and slat choices, our changing room benches will blend in with your existing decor or form the basis for a new colour scheme.
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Double Sided Hook BenchFrom
£395.84excl VATAn attractive and robust double sided locker room hook bench available in 7 colours and 3 widths (1000mm 10 Hooks, 1500mm 16 Hooks or 2000mm 20 Hooks) Learn More
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Status: RecruitingPhase: Diagnosis: GYN: Ovarian, Fallopian, Peritoneal CancerNCT ID: NCT01995188
(View complete trial on ClinicalTrials.gov)
DFCI Protocol ID: 13-483
This open-label, multicenter, phase 1b study will evaluate the safety and pharmacokinetics of DNIB0600A in patients with platinum-sensitive ovarian cancer. The maximum tolerated dose of intravenously infused DNIB0600A in combination with carboplatin will be determined in escalating dose cohorts. The combination of DNIB0600A and carboplatin will then be evaluated with and without bevacizumab [Avastin] in two dose expansion cohorts.
Conducting Institutions: Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital
Overall PI: Joyce Liu, MD,
Dana-Farber Cancer Institute
Site-responsible Investigators: Michael Birrer, MD, PhD,
Massachusetts General Hospital
Contacts: Dana-Farber Cancer Institute:
Christin Whalen,
firstname.lastname@example.com General Hospital:
Cancer Trials Call Center, 877-789-6100
Eligibility Criteria
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215 | Call us toll-free:


text:
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Sun 24th Mar at 8:30pm
Sarah-Jane Morris
@ 606 Club, London
Featuring: Sarah Jane Morris, Antonio Forcione
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Sarah Jane Morris
Sarah Jane Morris straddles rock, blues, jazz and soul with a goosebump-raising four octave range that rumbles from the heels of her size 8 shoes to the tips of her flame-red mane.
'A voice that can excite shivers of passion and delight... Soaring, swooping, sensual and sophisticated, this voice is more than a style, it's a force of nature... Torch song, soul standard or smoky blues, the message remains constant: human passion with a dazzling voice' (Neil Spencer, The Observer).
Sarah Jane Morris tour dates
Antonio Forcione
Breaking the mould of most conventional popular guitar sounds, whether in the field of jazz, Spanish, Brazilian, folk, felamenco, pop, rock classical or improvised music, Antonio Forcione draws on the full dynamic range of the instrument, using his entire body as a percussive tool. Dubbed the Jimi Hendrix of the acoustic guitar world, Antonio has recorded 16 albums and opened for Phil Collins, Bobby McFerrin and Jools Holland.
'Forcione is mesmerizing .. passion, grace and fire' (The Times).
Antonio Forcione tour dates
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Multiple Myeloma
|Study ID
|Multiple Myeloma
|Phase III
The drugs, lenalidomide, bortezomib, and dexamethasone, are approved by the FDA. They have not been approved in the combination for multiple myeloma or any other type of cancer. Bortezomib is currently approved by the FDA for the treatment of multiple myeloma. Lenalidomide is approved for use with dexamethasone for patients with multiple myeloma who have received at least one prior therapy and for the treatment of certain types of myelodysplastic syndrome (another type of cancer affecting the blood). Dexamethasone is commonly used, either alone, or in combination with other drugs, to treat multiple myeloma. Melphalan and cyclophosphamide, the drugs used during stem cell collection and transplant, are also approved by the FDA. Melphalan is an FDA-approved chemotherapy for multiple myeloma and is used as a high-dose conditioning treatment prior to stem cell transplantation. Cyclophosphamide is used, either alone, or in combination with other drugs, to treat multiple myeloma. These drugs have been used in other multiple myeloma studies and information from those studies suggests that this combination of therapy may help to treat newly diagnosed multiple myeloma.
In this research study, we are looking to explore the drug combination, lenalidomide, bortezomib and dexamethasone alone or when combined with autologous stem cell transplantation to see what side effects it may have and how well it works for treatment of newly diagnosed multiple myeloma. Specifically, the objective of this trial is to determine if, in the era of novel drugs, high dose therapy (HDT) is still necessary in the initial management of multiple myeloma in younger patients. In this study, HDT as compared to conventional dose treatment would be considered superior if it significantly prolongs progression-free survival by at least 9 months or more, recognizing that particular subgroups may benefit more compared to others.
- Diagnosis of Multiple Myeloma, according to the International Myeloma Foundation 2003 Diagnostic Criteria
- Documented symptomatic myeloma, with organ damage related to myeloma with laboratory assessments performed within 21 days of registration
- Myeloma that is measurable by either serum or urine evaluation of the monoclonal component or by assay of serum free light chains.
- ECOG performance status
- Negative HIV blood test
- Voluntary written informed consent
- Pregnant or lactating female
- Prior systemic therapy for MM (localized radiotherapy allowed if >/= 2 weeks before study entry, corticosteroids allowed if dose
- Primary amyloidosis (AL) or myeloma complicated by amylosis
- Receiving any other investigational agents
- Known brain metastases
- Poor tolerability or allergy to any of the study drugs or compounds of similar composition
- Platelet count <50,000/mm3, within 21 days of registration
- ANC <1,000 cells/mm3, within 21 days of registration
- Hemoglobin <8 g/dL, within 21 days of registration
- Hepatic impairment (>/= 1.5 x institutional ULN or AST (SGOT), ALT (SGPT), or alkaline phosphatase >2 x ULN). Patients with benign hyperbilirubinemia are eligible.
- Renal insufficiency (serum creatinine >2.5 mg/dl or creatinine clearance <60 ml/min, within 21 days of registration)
- Respiratory compromise (DLCO < 50%)
- Clinical signs of heart or coronary failure or LVEF < 40%. Myocardial infarction within 6 months prior to enrollment, NYHA Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conductive system abnormalities
- Intercurrent illness including, but not limited to ongoing or active severe infection, known infection with hepatitis B or C virus, poorly controlled diabetes, severe uncontrolled psychiatric disorder or psychiatric illness/social situations that would limit compliance with study requirements
- Previous history of another malignant condition except for basal cell carcinoma and stage I cervical cancer
- Inability to comply with an anti-thrombotic treatment regimen
- Peripheral neuropathy >/= Grade 2
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
Please remember:
- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.