text:
"Revolution" Ends, "TMNT/Batman:TAS" Begins in IDW's November 2016 Solicitations
Comic Books
Here's Marvel's next group….
40. Ultimate Captain America – 161 points (1 first place vote)
Steve Rogers was an American super-soldier during World War II, but was frozen after an explosion until he was thawed out in the 21st Century.
He became the leader of the superhero group, the Ultimates.
He is a lot like the regular Captain America, only he is much more of a soldier-type, and as such he can be a little more gruff than the regular Captain America.
In addition, he is very much a child of the 1930s, as he has fairly antiquated ideas about a lot of things, particularly things like chivalry.
He was created by Mark Millar and Bryan Hitch.
Scott Stafford had Ultimate Cap high on his list, and here are his reasons why:
There are a lot of key elements of Captain America's character that have been lost in the shuffle of decades of 616 continuity. Enter Ultimate Cap. The Ultimate Universe provided the opportunity to reboot Steve Rogers. Suddenly, he is once again a man lost in time. This element defines Rogers more than any other. Ultimate Cap has regained that conflict as he deals with a world that moved on without him.
NOW you can ask, "Who is this man?" Steve Rogers is a man with 1940's values and ideals. He is a veteran of the hardest war in the history of mankind. He has seen, suffered, and dished out major bloodshed because it was necessary. And he is a very, very dangerous SOB. Pluck that man out of the height of the war one day and wake him up sixty years later. This is the man you would be dealing with. Nearly everything he knows is gone. He has nothing left…except his country…and his ability to serve.
Over the years we've seen 616 Cap when he may as well be crying and wearing panties. There is little danger of a similar softening with the Ultimate version. If you need a butt-kicking, you're going to get it. If you stand in his way, he's going to move you. And if you hit your woman, you are most certainly going to regret it. His America is black and white, not a hundred shades of gray. THIS is Steve Rogers.
Thanks, Scott!
39. Human Torch (Johnny Storm) – 163 points
Johnny Storm, created by Stan Lee and Jack Kirby, liked to hang around his big sister. He was even willing to follow her on an unauthorized space mission with her boyfriend.
The end result was that Johnny gained the power to turn his body into flames. He used said power to make himself fly, as well as shoot flames.
Calling himself the Human Torch, Johnny joined the newly formed Fantastic Four, where he has served with ever since, and where he is now today.
38. Princess Powerful/Bruiser (Molly Hayes) – 167 points (1 first place vote)
Molly Hayes is a member of the group, The Runaways (created by Brian K. Vaughan and Adrian Alphona). The group is made up of children of the superpowered crime syndicate, The Pride. When the children discover that their parents are villains, they, well, run away. Molly, at 11 years old, is the youngest member of the group, and is often very amusing, in her sheer exuberance at being a real-life superhero.
Molly is a mutant and has super strength, although too much exertion causes her to fall asleep.
Joe Rice had her #1. Why, Joe?
Out of all the legions of characters in the Marvel universe, why the hell would I choose a little girl created in the past decade? I mean, I loves me some Ben Grimm, some Reed Richards, some Nick Fury, and even some Longshot (Shut up, I was a kid!), so how does Molly Hayes top all of them? Honestly, I'm not sure if I could even tell you. I don't even follow Runaways anymore. There's just something about her.
I suppose she reminds me of some of my favorite people. She's the sort of adorable spitfire I've always been drawn to, either as a friend, as a favored student, or as a character. She's cute, but she's real. Vaughan's characterization of her felt honest even when she was at her most obvious "here's the cute bit from Molly!" None of these, really, are probably enough to put her over some of the other great characters Marvel has. But that gentle honesty, that freedom to be cute while not being cutesy . . .it struck a chord with me. It's the fun missing in so many superheroes after lesser writers misunderstood why people liked DKR or Watchment. Innocent but aware . . .she's seen awful things but hasn't let them turn her awful.
We could all use a bit more of that. Princess Powerful 4-eva!
37. Invisible Woman (Sue Storm/Richards) – 170 points (1 first place vote)
Sue Storm, created by Jack Kirby and Stan Lee, was a great girlfriend to Reed Richards. She even agreed to go on an unauthorized space mission with him! And as a result, she and her brother were hit by cosmic rays and gained powers.
She joined the newly formed Fantastic Four along with her brother, Reed and Reed's friend, Ben Grimm.
She now had the power to turn invisible, and over time, she developed the ability to make invisible force fields.
She married Reed, and the two now have two children.
After the events of Civil War, where she and Reed were on opposing sides, the two have taken a break from the Fantastic Four to work on their marriage.
36. Rogue – 183 points (2 first place votes)
Rogue's powers developed when she was a young teen and she kissed a boy and her power to absorb people's powers and memories manifested horribly. Scarred by this, Rogue was taken in by her foster mother, the mutant terrorist, Mystique.
She ultimately made Rogue a member of her group, the Brotherhood of Evil Mutants, and set Rogue after Ms. Marvel, where Rogue absorbed Ms. Marvel's memories AND powers, making Rogue very powerful, but now fighting for control of her own mind.
She was forced to turn to the X-Men for help, and Professor X agreed to help her.
She joined the X-Men, and eventually became a valuable member of the team, even currently LEADING a squad of the team.
Luis Hernandez had her #1 on his list. Here is why:
She's my # 1 pick because she's a conflicted character. Not being able to touch someone without killing him/her must be tough to deal with. I think a lot of people feel like that sometimes: "Maybe i'm too fat, too ugly, too tall, skinny, etc… to ever find someone to have contact with"
I think a lot of people can identify with her. She has been portrayed as insecure, but then again she has shown she's a great leader that takes risks. She's humble and always someone you can rely on. Beautiful, smart and does have a lot of layers to her than a lot of other characters. A reformed villain who has always had a tumultous life since she was a child. I just think she's great and has a lot of potential to become more than what she is now. Mike Carey has done a tremendous job with her.
Thanks, Luis! That's it for today!
More on Monday!
I didn't know we could give you reasons why we voted for who we did!
Anyway, great to see two of my choices finally pop up in the form of badass Molly Hayes and lil' miss sunshine Rogue.
At last, 3 of my choices: Sue, Johnny, and Rogue.
Batman #1, Superman #2 for DC
Spidey #1, Wolverine (Logan) #2 for Marvel
T – I hate spoilers!
Jeez, T. You wanna give us a spoiler warning or something before you post those sorts of revelations? Next you'll be trying to tell us what happens at the end of The Empire Strikes Back.
Damn you and your speedy typing skills, Tomer.
Awesome, I had Molly high on my list so I'm glad she made the Top 50. I love the Runaways and she is easily the best part about it. So many of the series' classic scenes involve her, such as her punching Wolvine clear across the street or her punching the Punisher in the guts, leading to the all time best Punisher War Journal entry: "Uhhhhhhh…" Basically, anytime she punches something, hilarity ensues.
I think Molly summed it up herself with the line from Runaways vol. 2 #26:
"Why aren't you awesomed by me?!"
Molly punching stuff is indeed pretty good. I vote that if reality ever needs to be punched again, in whatever universe, Molly does it. The resulting continuity would have free Chocolate Frosted Sugar Bombs for everyone and no death ever.
Sue Storm higher than Johnny (not to mention her husband)? That's interesting. Overall this has been a lot more fun and less predictable of a grouping than I was imagining…
So far, none of my picks from either list. There are a few I am pretty sure won't make it (how many people out there voted for The Looter?) but there are some I am on the fence about the chances of.
Interesting that 3 of the Fantastic Four are grouped pretty close together.
I would bet that the Thing is at least another 10 places ahead of Sue.
Interesting too that only Sue got a #1 vote. I would have never in a million years thought that Reed would poll lower than Sue and Johnny. Damn you, Millar!
I figure Ben for the top ten for sure.
I was kinda shocked when the whole first issue of Ultimates took place during the war, but seeeing what they've done with Steve, it makes sense now. It's been nice to see that explored in a way that Stan didn't have time for in Avengers, and that few writers have done much with in Cap's own title.
Rogue? meh
I'm going to have to get that Runaways TPB.
Sue's the first Marvel character from my ten to make the list. I've always found her to be the strongest and most engaging member of the FF (well, at least once the writing got less sexist and she no longer spent her free time trying on wigs). If Reed's the brains of the Fantastic Four, then Sue is its heart.
None of these particularly resonate with me as favorites, but Ultimate Cap would come close. I've never thought Johnny or Sue had that much personality. Don't know Bruiser and Rogue is ok but not a fav.
If Ben Grimm doesn't make the top ten, something's seriously wrong….
Go Molly! I really wanted to put a Runaway on my list, but couldn't bring myself to single one out; if I had, it would have been her (or Gert).
I have to say, one of the best things about reading these list is bits from people explaining why they picked the character they did. In many instances, it makes me rethink my choices-"ah, they're right, I should have put so and so on my list." If nothing else, it reminds me of what I love about so many characters.
Ultimate Cap was on my shortlist, but in the end his place went to another Ultimates character.
So far only The Spectre and Howard the Duck have made it from my lists, but it's good to see them both up there. Even if The Spectre's waaaaay too low.
I like Vaughn's Runaways, but wasn't Molly in Power Pack when I was a kid? Isn't she basically the exact same character?
No, that's Katie Power.
They're different.
Also: Johnny higher up than Reed!?!
Somebody is going to die.
Shoulda voted. $%^$^ Millar.
Did Johnny ever outwit the dreaming celestial?
Did Johnny defeat Robo-Stalin?
Does Johnny EVER outwit Doom when it's all on the line?
No. Johnny's a moron.
I can totally understand liking Ben better. Everyone loves Ben. I can sorta understand liking Sue better. But Johnny?!?!?!?
Molly for the win! She's not my favourite Runaway, but it's good to see one on the chart (maybe we'll see Nico and Gert or somebody higher up…?). It is simply priceless entertainment to see her totally own Wolverine…and the Punisher.
I'm pretty amazed to see Rogue that far down. I always thought she was a more popular character than that.
*glowers at Ultimate Cap*
I figured if anyone from Runaways got a nod, it would be Molly. She's just utterly quotable and fun. Interesting that Brian K. Vaughn got a creation onto the Marvel and DC lists at the same time.
Wow, THREE of my top ten in this list alone:
Rogue (my #1)
Ultimate Cap (my #4)
and Human Torch (my #8)
Too bad Rogue didn't get higher. I like those tragic heroes like her, Robotman, Martian Manhunter, Crazy Jane, Scarlet Witch, and Thing.
And you know, I totally didn't think about Runaways when I made my list, but ALEX would have been a good addition to my top 20.
I like the Fantastic Four. As a team they're a top ten pick. That's their strength– a team, a superhero family. Singularly they only seem parts of a whole. As individual favorites I understand their lower rankings. Like most people, the Thing's my favorite (in the books, anyway). Followed, and this is where most of us jockey around, by Mr. Fantastic, Invisible Woman, and the Human Torch.
I don't know how I feel about Ultimate Cap. Not sure that version is all that well-established.
But I am glad to see Molly. She and Jessica are two new characters worthy of noting.
And I've always loved Rogue. The inability to touch anybody always struck me as a powerful character gimmick. She'd have made my top 25.
Halfway through the voting, neither Sue NOR Johnny were in the Top 50!
Freaky, huh?
Reed was much higher. The last couple hundred votes were hard on Reed and good to Sue and Johnny.
No one from my list made it this round, but I did vote for Gert and Chase from Runaways, so I'm happy that Molly made it! I am also happy to see Johnny Storm place as well as he did. In this age of pet characters and X-domination, it is good that classic characters I have loved since my youth are not forgotten, either. Spider-Man is the everyman; the Human Torch is who you want to be.
Thought: Did the FF movies raise Johnny's stock? Because the actor who plays Johnny in the films really does a good job with the character, and seems to get all the good one-liners.
That virgin-whore complex is very strong, apparently.
Ultimate Captain America? Man, if I'd known slight variants like that rated their own entries, Marvel Adventures Hulk and Mini-Marvels Hulk would have taken up two slots right off the bat.
And I've always loved Rogue. The inability to touch anybody always struck me as a powerful character gimmick. She'd have made my top 25.
Mm-hm, me too. Hate her accent (just generally hate the Marvel habit of carefully s-p-e-l-l-i-n-g-o-u-t each character's ethnicity) but she's an amazing concept as a tragic heroine.
Ultimate Cap? Johnny Storm? Molly Hayes? Rogue?
If those are among the top 50 Marvel characters, no wonder had so much trouble hitting ten characters.
Can't say the FF surprises me. Really, when was the last time someone thought "wow, these guys are the awesomest!" about the FF? Back in the '60s? Maybe for once, could Marvel have a mega-crossover where the FF (and Spidey, for that matter) get center stage and save the universe, rather than being the punked-for-the-sake-of-hyping-a-threat cannon fodder for the Avengers or X-Men?
But Rogue surprises me. Isn't she STILL voted Favorite Female Hero by the WIZARD readers every year? Even adjusting for voter fraud, mutant bigotry, Yankees, Ms. Marvel fans, and people who like to be touched, it's shocking to see her so low. Unless the remaining 35 characters are all men…
Well, the thing with the FF is that they're created to be team characters, and people think of the FF *as* a team. So it's not too surprising that, rated as individuals, they'd be clustered near each other, and not nearly as highly-ranked as they would be for something like "favorite teams."
Ben Grimm was the "breakout character" exception to that rule
Sue Richards has been my favorite member of the FF for a long time. I agree with M Bloom that she's the heart of the team. She's also the glue that holds the other three together, the big sister/mother-figure who has kept each one of them in line at one time or another, made them say sorry and take a little time out when necessary.
I cringed at Alba being put in the movie role, as I do at the current way Sue is portrayed in the book (typified by the illustration you chose for this post- she looks sixteen, and what's with those giant feet?)
As for Johnny, there was no super-hero I more wanted to be when I was twelve. My school books used to be covered with little red-ink human torches. And he was the only character that I thought really worked in the movie.
He's also a moron who couldn't defeat alternate universe disney built robo stalin, or the Black Celestial.
Also, no offense to Sue or anything, but Ben's the heart.
Ultimate Cap was my #5. He's a fantastic character – and so much better than the standard version, though Ed Brubaker has done a lot to bring the standard one up.
Halfway through the voting, neither Sue NOR Johnny were in the Top 50!
Freaky, huh?
Reed was much higher. The last couple hundred votes were hard on Reed and good to Sue and Johnny.
You could probably do some profiling about what type of people vote for what kind of character. Personally I like to mull over a list like that for a couple of days so I guess I'd be a late voter.
I was one of those people who didn't put any of the FF on my list, whereas I would have put the Fantastic Four in my top 10 if teams counted. My apologies to all four of them.
My list is similarly lacking in X-Men, despite my love of the X-Men. My apologies to all 873 of them.
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(06-10-26 12:32:03):
> I want to create a directory 'myDir' where the user will be able to
> freely create and erase files and directories, but could not modify
> the permissions of 'myDir' directory itself. What is more no other
> user in the system can access this directory and its contents. Hope
> you can help me,
Yes, the owner-user should be you, but the owner-group should be a
dedicated group, which only contains the user, who should have access to
the directory. Others shouldn't be able to access the directory, so its
permissions should be like 770.
A much better approach is to use ACLs.


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Admitted in 1985, Nigel acts on behalf of the NHSLA, NHS Trusts, PCT's and the MDU advising on all aspects of risk and claims.
He has 15 years experience of handling clinical negligence claims across all areas including cerebral palsy, oncology, paediatrics and plastic surgery. Advisory work includes strategic analysis and implementation of Trust policies, procedures and training in relation to clinical and health & safety risk.
Nigel is a regular author of articles to health and risk management publications and speaker at conferences on medico-legal issues.
He leads a dedicated team in Bristol acting for healthcare providers in the public and private sectors and is head of the firm's public health and independent health sectors.
Nigel is a member of the Law Society's Clinical Negligence Reference Group.Nigel Montgomery - is "very highly rated indeed"Chambers UK 2013 Edition, Clinical Negligence UK Wide
DAC Beachcroft LLP has a strong and highly rated national team headed from the Bristol office by the "hugely experienced" Nigel Montgomery.Legal 500 UK 2012 Edition, Clinical Negligence, London
DAC Beachcroft LLP has a strong and highly rated national team headed from the Bristol office by the "hugely experienced" Nigel Montgomery. It has one of the largest portfolios of work for the NHSLA including several complex group actions and the firm features a nominated NHSLA partner at each of the Bristol Winchester Leeds and Newcastle offices. The breadth of experience in the team is also illustrated by its non-NHSLA client list which includes the MDU private healthcare providers such as Spire and the Priory Group and medical malpractice insurers such as Allianz QBE and Zurich."Legal 500 UK 2012 Edition, Clinical Negligence London
Nigel Montgomery is the national head of the department, and is highly praised for both his individual practice and his leadership of the wider group.Chambers UK 2011 Edition, Clinical Negligence, London & UK-wide


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PACE has received notice that the Commonwealth has received approval to extend both the Commonwealth Care (CommCare) and Temporary Coverage (through Mass Health FFS Standard and Limited) programs through Dec. 31. Members currently enrolled in these health insurance programs will receive notification of this extension by mail next week.
Premium paying members enrolled in Commonwealth Care must continue to pay their premium bill in full and on time in order to remain in this coverage. Members enrolled in temporary Coverage do not need to take any action at this time to continue to access this coverage.
Due to the technical problems with the website, the Connector has been unable to issue program determination to applicants. Both programs have been extended to ensure that members keep health insurance while the technical problems are resolved.
Members will get more information in the future letting them know about any next steps they will need to take. Until that time Members will continue to keep Commonwealth Care, if they still qualify and continue to pay their premiums, or Temporary Coverage through December 31, 2014 or until their application is processed.
If a Member has any questions about their Temporary Coverage they should contact MassHealth Customer Service at 1-800-841-2900.
Commonwealth Care Members may contact the Health Connector's Commonwealth Care Customer Service Center at 1-877-623-7773 with any questions about their current coverage.
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text:
Lick the Cat Summer Hits
The boys of summer. Wait, that's the 80's.Read More
The boys of summer. Wait, that's the 80's.Read More
Arnette is back with their webisode series.Read More
Follow Sage Kostenburg as he road trips from Utah to Mammoth for the West Coast Invitational where Sage claims the Best Trick Award. From there, Sage treks up to Oregon for Superpark to link up with the Nike crew for the Battle of Brands.Read More
Words & Photos: Sean Kerrick Sullivan Park City Mountain Resort opened 8 runs and 3 chairlifts on Saturday, November 19th for their official opening day. With approximately 30 features, including a smooth jump courtesy of Jeremy Cooper's hard working park crew, the only word to use here is solid. 6 inches of fresh snow fell on the preceding evening making conditions prime for cruising, jumping, jibbing, and hollering at cougars. "If this is how good PC is on opening day, then I definitely don't need to spend a month in Breck" said @SageKotsenberg in between instagram sessions, "I can ride a perfect park here at Park City with all my friends, the rails and the jump are so fun, and its only going to get better."Read More
Nike assembled a big group of their pro snowboard team in Norway to hype up their Vapen boot. Not sure why they chose Norway. Italy would have made more sense. Either way this is a pretty big budget teaser for the series of videos they'll be releasing which features the riding of Sage Kotsenberg, Halldor Helgason, Gigi Rüf, Nicolas Mueller, Gjermund Braaten and others.Read More
Sage Kotsenburg graced us with his presence at the SNOWBOARDER office. See what he had to say in his Guestbook.Read More
Mark Dangler put together a Celtek edit from Superpark 14 up at Mammoth. This one features Dylan Alito, Johnny Lazz, Sean Black, Ted Borland, Jonah Owen, Sage Kostenburg, Eric Willett, and a handful of others.Read More
Mistaken Production's teaser for their Colorado based snowboard film, "Sup Bro?"Read More


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You have to break a few (hundred) eggs to make a good crystal
Space Science News home
You have to break a few (hundred) eggs to make a
good crystal Bell curve shape to crystal quality
may point to best candidates for flight
Sept. 20, 1999: Did you ever ask the teacher to grade a tough test "on the curve"? What you were asking was that the grades be adjusted so that a "C" fell under the part of the curve where most of your classmates had scored. A few were to the left and got a D or F; and few were to the right and got a B or an A.
Right: To the crystallographer, this may not be a diamond but it's just as priceless. A lysozyme crystal grown in orbit looks great under a microscope, but the real test is X-ray crystallography. The colors are caused by polarizing filters. Links to 549x379-pixel, 69KB JPG. Credit: NASA/Marshall.
That's basically how the bell curve works. In nature, objects and events quite often can be grouped along a bell curve. In a population of adult animals, most will be around the same size. A few will be larger and a few will be smaller.
"If you talk to statisticians," noted Dr. Russell Judge of the University of Alabama in Huntsville, "variations within populations in nature can be described in terms of distributions."
December 3: Mars Polar Lander nears touchdown
December 2: What next, Leonids?
November 30: Polar Lander Mission Overview
November 30: Learning how to make a clean sweep in space
The question now is whether scientists can use the microgravity of space to shift the curve to the right to grow the large, nearly perfect crystals they need for molecular lock-picking, the first step in designing drugs that can treat a broad range of diseases and disorders.
"We want to determine how the growth of crystals effect their quality," Judge said in May when NASA selected his investigation for development, "and then take that into space to see how microgravity is enhancing the growth characteristics that lead to good crystals. From this we want to develop techniques, so that by observing crystal growth on the ground, we can predict which proteins are likely to benefit the most from microgravity crystallization."
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These functions are a result not just of a chemical formula, but of structure which can be quite large (on the atomic scale) and fragile. If the shape isn't right, the protein cannot match up with other proteins or chemicals to do its job, just as the wrong key won't unlock a door. Sickle cell anemia, for example, results from structural differences in the hemoglobin that carries oxygen in red blood cells. Designing new treatments means designing altered proteins or other chemicals that act as a skeleton key or as a sophisticated lock pick.
Proteins can form crystals, generated by rows and columns of molecules that form up like soldiers on a parade ground. Shining X-rays through a crystal will produce a pattern of dots that can be decoded to reveal the arrangement of the atoms in the molecules making up the crystal. Like the troops in formation, uniformity and order are everything in X-ray crystallography. X-rays have much sorter wavelengths than visible light, so the best looking crystals under the microscope won't necessarily pass muster under X-rays.
Left: Judge (left) and Dr. Edward Snell, a National Research Council fellow working at NASA/Marshall, inspect the sample holder in the X-ray crystallography unit. Links to 600x616-pixel, 188KB JPG, or click here for a 1207x1240-pixel, 543KB JPG. Credit: NASA/Marshall.
This has become an invaluable tool for understanding the structure and the function of dozens of proteins. But many proteins remain shrouded in mystery because on Earth crystal imperfections are introduced by fluid flows and the settling of the crystals to the bottom of the container. This leaves internal defects that distort or blur the view of the structure.
"In order to have crystals to use for X-ray diffraction studies," Judge said, "you need them to be fairly large and well ordered." Scientists also need lots of crystals since exposure to air, the process of X-raying them, and other factors destroy the crystals. Getting just one perfect specimen isn't enough. Dozens may be needed, and the quality might not be known until well into the analysis.
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Research has Heavy Implications. July 1998. Crystal-clear
view of insulin should lead to improved therapies for diabetics
Growing protein crystals in the microgravity of space has yielded striking results, such as determining to a fine resolution how certain molecules of insulin join so scientists can improve injectable insulin needed by diabetics. There have also been disappointments when crystals in other experiments did not grow as expected.
Since the 1970s, scientists have used a variety of approaches in trying to determine what leads to the growth of a large, perfect crystal. Judge tried a different approach that built on results noted by researchers dating as far back as 1946.
He and his team looked at the effects of concentration, temperature, and pH (acid vs. base) on the growth of lysozyme, a common protein in chicken egg white. Lysozyme's structure is well known and it has become a standard in many crystallization studies on Earth and in space. Although lysozyme has an atomic mass of 14,300 Daltons - almost 92 times that of the ordinary sugar that many of us crystallized in elementary school science - it's a relative lightweight in the protein world.
To exclude impurities often found in commercial lysozyme preparations, Judge and his team purified lysozyme extracted from eggs obtained from a local egg farm. While one experiment run required only five dozen eggs, the full series of experiment consumed about 200 eggs.
Judge and his team grew the crystals in trays with small plastic wells filled with solutions containing a trace of salt to help stimulate crystal growth. Temperatures ranged from 4 to 18 deg C (39-64 deg F) and pH from 4.0 to 5.2 (slightly acidic; pure water theoretically has a pH of 7). Judge also varied the driving force behind the crystal growth process, called supersaturation, by varying the initial concentration of protein. Protein concentration must be set above a critical limit, the solubility, in order to form crystals (below this concentrations the protein stays dissolved and never forms crystals)
Left: A bell curve for lysozyme crystals produced in Judge's experiments, and a possible shift in the curve that microgravity experiments might produce. Links to 660x440-pixel, 39KB JPG. Credit: NASA/Marshall.
The tough part was examining each of the over 2000 wells and counting the crystals. It turned out that the solution pH had the largest effect on the growth of the crystals, possibly due to changes in charges on the surface of the molecules.
When solution conditions had been optimized to give a small number of large crystals, a sample of 50 crystals was withdrawn for X-ray diffraction analysis.
Judge hoped that when the ideal conditions were found and then applied to subsequent batches, he would be able to grow consistently large, high quality crystals of lysozyme. The expectation was that with ideal conditions, quality crystals could be cranked out as if in a factory.
Instead, nature put him on the curve.
"Some variation is occurring there," Judge said, "but we haven't quite pinpointed the cause."
Judge got a bell curve when he measured the X-ray clarity, properly called the signal-to-noise ratio (a radio with static has a low signal-to-noise ratio). A graph of the number of crystals versus the signal-to-noise ratio forms a bell curve, albeit slightly skewed to one side.
Right: Distribution of diffraction characteristics - essentially a measure of quality - for a batch of crystals approximates a bell curve. Links to 875x637-pixel, 66KB JPG. Credit: NASA/Marshall.
"The distribution is saying a very few crystals form perfectly in solution," he continued, "and a small number are really poor. The majority of crystals are in-between."
It's doubly puzzling because the crystals were grown from the same batch of lysozyme that was poured into 120 wells in the experiment tray and crystallized under the same conditions.
"We have some ideas," Judge said, "but we haven't tested them yet, so we're hesitant to say it might be this or that."
The research will continue with insulin, the crucial protein that conveys sugar from the blood stream into a body's cells, and with glucose isomerase, a larger (46,000 Daltons) protein used in industrial processes to convert glucose to a sweeter sugar called fructose.
Left: Crystals of insulin grown in space let scientists determine the vital enzyme's structure and linkages with much higher resolution that Earth-grown crystals had allowed. Links to 640x448-pixel, 104KB JPG. Larger format versions of these and related images are available from the NASA Image Exchange and using the keyword "insulin." Credit: NASA/Marshall.
"In all of the proteins we're using the structure is pretty well known," Judge added.
In addition to ground-based experiments, Judge hopes to conduct flight experiments in the next year or so. He would use the Vapor Diffusion Apparatus, a device developed by the University of Alabama in Birmingham and well-proven in a number of Space Shuttle flights.
"Most researchers say that crystals grown in microgravity will be better than those on the ground," Judge said. And a number of experiments bear out that belief. "Somehow, microgravity pushes up the end of the distribution curve."
Right: Crystals of glucose isomerase, a larger molecular weight protein, will be grown to see if they, too, are graded "on the curve." Links to 1018x749-pixel, 365KB JPG. Credit: NASA/Marshall.
With expected flight experiments on lysozyme, insulin and glucose isomerase, Judge will have crystals grown in conditions as close as possible to the ideal conditions he had determined so far. At the same time, he will grow crystals on Earth from the same mix as the flight batch and using identical hardware and conditions so that microgravity is the only variable.
Eventually, he hopes that his studies will lead to a tool for screening candidate proteins for flight.
The Effect of Temperature and Solution pH on the Nucleation of Tetragonal Lysozyme Crystals. Biophysics Journal, September 1999, p. 1585-1593, Vol. 77, No. 3
Russell A. Judge,*Randolph S. Jacobs,#Tyralynn Frazier, §Edward H. Snell, and ¶Marc L. Pusey
*Alliance for Microgravity Material Science and Applications, NASA/Marshall Space Flight Center, Huntsville, Alabama 35812; #Department of Chemical Engineering, University of Alabama in Huntsville, Huntsville, Alabama 35899; § Biochemistry Department, Michigan State University, East Lansing, Michigan 48825; and ¶Biophysics SD48, NASA/Marshall Space Flight Center, Huntsville, Alabama 35812 USA
Part of the challenge of macromolecular crystal growth for structure determination is obtaining crystals with a volume suitable for x-ray analysis. In this respect an understanding of the effect of solution conditions on macromolecule nucleation rates is advantageous. This study investigated the effects of supersaturation, temperature, and pH on the nucleation rate of tetragonal lysozyme crystals. Batch crystallization plates were prepared at given solution concentrations and incubated at set temperatures over 1 week. The number of crystals per well with their size and axial ratios were recorded and correlated with solution conditions. Crystal numbers were found to increase with increasing supersaturation and temperature. The most significant variable, however, was pH; crystal numbers changed by two orders of magnitude over the pH range 4.0-5.2. Crystal size also varied with solution conditions, with the largest crystals obtained at pH 5.2. Having optimized the crystallization conditions, we prepared a batch of crystals under the same initial conditions, and 50 of these crystals were analyzed by x-ray diffraction techniques. The results indicate that even under the same crystallization conditions, a marked variation in crystal properties exists.
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Alabama Chief Justice Roy Moore is headed to the nation's highest court. In a statement issued Tuesday, Moore said he wants the U.S. Supreme Court to decide the legality of a Ten Commandments monument housed in the Alabama Judicial Building.
Two federal courts have ruled the monument's presence in the judicial complex is unconstitutional.
Moore had the choice of asking the full 11th U.S. Circuit Court of Appeals to rehear the case. Tuesday was the deadline.
During a July 16 appearance on Alabama Public Television, Moore compared his Ten Commandments monument to the statues of the Greek goddess of justice outside courthouses, saying both may offend some people but that doesn't make them unconstitutional.


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Carbohydrate Addicts Diet
If you're a carb addict, don't think you can't reward yourself... daily!Top Rated Diet Shakes of 2016
Do you often enjoy a large meal and soon after feel hungry again? Or, do you feel like you can't stop eating starchy goodies once you've started? It's time you faced up to your addiction to carbs. You're not alone and the Carbohydrate Addict's Diet might just be the plan for you.
It's possible your body doesn't process carbs the way everyone else does. Sometimes, carbs in your body will result in substantial production of insulin, which in turn creates fat stores. The Carb Addict's Diet, created by Dr. Richard and Dr. Rachael Heller, manages your insulin level by helping you eat in a way that properly mixes when and what you eat. You'll even get to fight the addiction with your food must-haves.
Do You Know the Best Diet Shakes of 2016?
Carbhydrate Addicts Diet, Carbahydrates Addict's Diet, Carbohydrate Addict's DeitPRO
- Allows for a substantial portion of daily carbohydrates
- May help to control imbalanced blood sugar levels, sugar cravings and mood swings
- Nutrient-less carbohydrates are replaced by nutrient-rich foods
- May help you to lose weight
- Consuming too many unhealthy carbohydrates has been linked to obesity, diabetes and other chronic health conditions
- Specific instructions for reward meal are needed
- Reward meal may turn into a 60-minute binge fest for those feeling truly carbohydrate-deprived
- Restriction of fruit is disputed by some nutrition experts
- Weight loss is likely to be temporary unless the dieter restricts their carb intake for the long-term
True to its name, the Carbohydrate Addicts Diet restricts certain carbohydrates from your diet while allowing you to eat a modest of amount of approved carbs.
During the first two weeks of the diet, you follow a fairly strict plan of eating only certain foods and foods delineated in the Complimentary Meals list. Such foods include:
- Meat and poultry
- Fish and shellfish
- Fats, oils and dressings
- Eggs and dairy products
- Vegetables and salads
- Special low-carb desserts (recipes in book)
Three meals a day are allowed. Breakfast and lunch must be protein plus low-glycemic vegetables. Dinner is referred to as your reward meal where you can eat whatever you want as long as you eat it in a one-hour time period.
Once you finish with the first two weeks of the diet, you gradually start to re-introduce certain carbs back into your diet, but the quantity and kinds of carbs are dependent upon your weight loss goals. The same reward meal applies.
A sample day on the Carbohydrate Addicts Diet might look like this:
- Breakfast: Omelet made with a combination of egg whites and one whole egg, bell peppers and mushrooms
- Lunch: Romaine lettuce salad topped with grilled chicken breast, cucumber slices and olive oil and lemon juice
- Snack: Hard-boiled eggs or string cheese
- Dinner: Modest serving of pasta marinara and topped with Parmesan cheese shavings, served with sauteed broccoli.
Foods that are to be avoided during the day are:
- Fruit
- Fruit juices
- Bread
- Pasta
- Sugar & sweets
- Processed food
You are encouraged to be consistently active while following the Carbohydrate Addicts Diet. Clocking hours at the gym or on the StairMaster is not recommended, but rather you should aim to move your body more through modest exercise and in your daily routine.CONCLUSION
Carbs have certainly received a bad rap in recent years as more and more research shows that diets high in refined carbohydrates can lead to weight gain and out-of-whack insulin levels.
While it's great dietary practice to limit the amount of refined carbs you eat, completing nixing fruit or even the occasional candy bar is just not realistic or healthy.
Even though the Carbohydrate Addicts Diet is likely to result in weight loss and receives high marks for its inclusion of lean protein and healthy veggies, its permission of a reward meal may lead to pasta binges and the resulting weight loss is likely to be temporary, once you cycle off the diet.How Does Carbohydrate Addicts Diet Compare?
- Product Name
- User Rating
- Has Good Appetite Suppressant
- Has Only Natural Components
- Good Taste
- 18Shake
(Editor's Choice)
- 97/100
- Yoli YES
- 92/100
- Isagenix
- 83/100
- Ideal Protein
- 71/100
- Vega One
- 66/100
- Carbohydrate Addicts Diet
- /100
User Feedback(Page 4 of 5, 87 total comments)
I 've tried other low carb diets & always feel much healthier when I cut the carbs & eliminate sugars. So I know that low carb is the way I want to go. Unfortunately, I haven't been able to stick with other low carb diets for more than a couple months. I've realized that completely eliminating the foods I love the most like fresh fruits, pasta dishes, authentic Mexican food, or fresh baked bread, etc., for the rest of my life just isn't gonna happen. I have to stop deluding myself about that no matter how appealing and easy the diet authors make it sound.
Successful Atkins dieters have done it and I admire them. But I'm done with that diet. And tired of reading all their success stories while I keep failing at it.
And not just Atkins, but all of those other overly sweet meal bars, and drink mixes just gag me after while. What's up with that extreme sweet anyway.
I'm ready to give the Hellers' diet a try and am excited and hopeful.
I want to get 50 lbs of ugly blubber off me and am detemined once again.
Wish me luck. I'm starting today.
It's Easy and it works. South Beach is a lot harder to stick with. This gives you all the benefits of low carb while giving you at least one meal you can splurge on. After a while you won't even want to splurge but knowing you can is nice.
This is my favorite diet. I've already lost 5 lbs in less than two weeks. This diet works best for me because it reduces my cravings in the day, and the thought that I can have almost anything I want at least once a day keeps me sane. I usually have a coffee or redbull in the middle of hte day to keep my energy up, but the caffeine adds even more to my appetite suppression.
Give this a try. I think the reason why this diet works so well is because it (1) reduces cravings and helps you to eat less, (2) stops you from snacking throughout the day, and (3) gives you permission to your favorite foods at least once.
GOod luck!
110 lbs off............need more info?
I've been on this plan for a little under a week now, and I've already lost 4 lbs. No cravings, no stomach upset, no problems whatsoever! We'll see how it goes over the long haul, but so far, so good!
Tried and loved this program.....but as the norm. fell off and am having a hard time restarting. Going to the Library tomorrow to reborrow the book. Having the book as reference is definitely helpful. The most difficult part I found was trying to watch all the eggs, cheese etc. regarding cholesterol. Any suggestions for breakfast?????
This diet is my all time favorite ever. It reduces cravings, and stops you from snacking all night. I started on July 1st and have lost 25 pounds so far (it's November 2nd 2008 today) without excersice and I feel great. Try to get the newest version published in 1991 because the versions released after are a little different as far as balancing your reward meal and what you eat for complimentary meals. Read the book from beginning to end, keep going back to read it over and over so you don't forget the basic rules. Make sure that you aren't accidentally eating hidden sugars in your complimentary meals, and stay away from msg on your complimentary meals as well. Don't get discouraged about the scale becasue you will be up and down and all over the place. Good luck to you!
I did this plan for eating 7 years ago and lost 20 lbs. I could not believe it, I was eating coffee rolls from dunkin donuts all the time at my reward meal and still losing weight.. I ended up having knee surgury and couldn't contiue it.. I'm back on it again and need to lose 25 to 30lbs. I don't feel hungry. sometimes I feel that I dont eat enough during the day and OVER DO IT at my reward meal.. I have decided to make cereal my carb snack at night. NO MORE SUZI Q'S and CHIPS... GOOD LUCK TO ALL
you said in your book not to go on this diet if you have an autoimmune disease (i have hypothyroid) or if you have diabetes. my glucose level is about 100 (borderline). i went on it anyway and wonder if i am damaging myself? also will it make me insulin resistant?
i travel a lot, and it is impossible for me to stay on the diet while travelling. will going on and off the diet all the time be damaging to my body?
I started the Carbohydrate Addict's Diet 1 year ago today (10/8/08). I have lost 60 pounds and feel wonderful. This diet is simply amazing! If you can stick to it everyday you will have success too! And to the person who asked about the low carb bars. No you cannot have those on this diet except at your reward meal. Be very careful not to go by net carbs, only grams. Its a common mistake at first but it can throw off your whole day.
I started this diet. On 10/4/2008. I thought there is no way I can lose weight eating dessert. But, low and be hold it works. this is 10/7/2008 and I have already lost 2lbs. It is great! I put my husband on it too. He was optomistic at first but, he is starting to get into it also. Hopefully we will get healthy again.
Can you eat the low carb bars on this diet? These bars show high carbs but low IMPACT carbs. - Thanks for any input.
Can you eat the low carb bars on this diet? These bars show high carbs but low IMPACT carbs. - Thanks for any input.
I, too, have had great success on this diet. I made sure also that my calories and fat for the Reward Meal were not out of control and changed all my grains, including pasta, to 100% whole grains. I increased fiber to the recommended 25-30 g per day and lost weight consistently. Most often, dessert was a piece of fruit. The weight came off and I am not young with a young person's metabolism. I first tried this diet in my late forties and am about to go back on it at the age of 50 because I allowed myself to return to bad habits. I highly recommend this diet.
I did the diet about 7 years ago. I had the complimentary meals and during my hour I ate a balanced meal but I ate whatever I wanted. I did what she talked about in the book. Broke the meal up into categories. I had something for appetizers, main course and dessert. I was sooo stuffed in the end that I didn't even think about anymore food all night. I also chased everything down with coffee.................. I lost 48 pounds. I was soooooo ammazed! I love this diet.
I'm losing weight slowly because at first I ate too much at my reward meal. now that i've returned to my senses its coming off faster. 15# in 4 months so far. It just takes some creativity, i dont follow the recipes. my favorite dinner is salmon/broccoli/garlic bread/red wine . YUM! other regular meal foods I like are celery and cream cheese, eggs N bacon, cottage cheese, salads, salads, salads . A hot dog and chocolate shake fits in the plan too.! Dont give up on it, write down that weight. Good Luck.
I did this diet about ten years ago when I was 37 years old. It was like a miracle for me because after having two children and getting them to a reasonably comfortable phase, I just could not seem to lose the weight. I would sometimes not eat anything all day and then find myself in a convenience store having a doughnut and coffee to reward myself for driving in the snow and working. It was a terrible thing. So, I began it at Easter with candy all around and was able to have a bit if I felt like it at my reward dinner. I lost sixty pounds and kept it off for three years, then had a bit of trouble keeping on it, and jumped back on it again. I maintained my weight for several years with this plan. I went off of it for several years but have just begun it again after undergoing a hysterectomy and surgical menopause which spurred a weight gain of about twenty pounds. I've lost six pounds in a few weeks, and feel back in the driver's seat again. Like others, I would really eat everything I could think of at the reward meal at first, and now I don't bother. I had to use my reward for a junky catered food meal at work and still the weight went down. Trick to this is weighing daily, averaging then entering weekly average to chart. Trust me. Best of luck!
usa red water all dog water girl vacant student man
I know that I am a Carbohydrate addict. This diet has been a blessing for me. I've had the book in my night stand for many years finally four weeks ago I started reading it and I thought oh my goodness I can do this. If this works it will a great way for me to control my appetite and break my carb addiction. I started the day after my 48th birthday and 4 weeks later I'm already down 10 lbs and I never feel hungry and I even have to remind myself to eat both complimentary meals. I don't even need the snack meal. At first I was out of control with the reward meal but now I just eat a regular meal with a desert within one hour. I don't even think about a snack at night I'm just not hungry!!! I am amazed at the energy I have too. This is by far the best diet/lifestyle change I have ever done. I've been telling everyone to try this diet because it is so easy and it WORKS!!!!. This IS the diet you've been looking for...Good Luck! God Bless
I did this plan 5 years ago and lost 30 lbs. I unfortunately went on vacation and got out of control with the carbs and gain every bit back plus some. I have tried other things, eating right and I have a limitation to exercise since I have osteoarthritis, but I can still walk. I will go on this plan again. The first time I didn't even buy the book I got it from the library, but this time, I'm going to get the book and shed this weight to take the pressure off my joints. Wholeheartedly recommend it.
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Carbohydrate Addicts Diet?


text: 02 March 2012 archive See all show photos IT makes complete sense, really, that a fashion collection should be so literally inspired by specific gestures relating to clothes. And so in steps Maison Martin Margiela, which took attitudes or rather movements – "over the shoulder", "hands in pockets", "stand-up collar" - as its starting point today and then transformed them into re-appropriated volumes and shapes so things were no longer as they seemed – this is the house of Martin Margiela and it just wouldn't be right without a bit of mystery and intrigue after all. "It was a really brilliant play of all the Margiela traits, the obsession with shoulders, the deconstructed dresses, half and half trompe l'oeil effects, the plastic coating on cotton shirts. It was subtle but with well constructed twists," said Vogue's Harriet Quick after the show – the twists she noted extending even to the very seats we were sitting on that seemed to seep into the parquet floor, covered in trompe l'oeil flooring as they were too. It was all very much done in that Margiela vein and just when you thought you knew what the item coming down the catwalk was, you had to stop and think again – nope, that wasn't a smoking suit, it was actually a dress in the guise of one, the trouser legs defined by a sassy split. There were trousers in the plenty that fell over the fronts of boots and shoes, and sharp boxy, but neatly cut jackets that sat just so on the shoulders. Arms looked like they were in sleeves that were tucked into pockets but in fact it was just the sleeves, no arms – these were folded behind the model's back, but the sleeves in question had been cleverly built into the cape-jacket being worn. Dresses and jackets looked like they had been pulled from the cutting table and were still in a state of being made – this was deconstruction at its best and kimono dresses were beautifully assembled into square patches of elegant scrap-piece dresses. Perhaps a lesson in customisation, perhaps a lesson in make do and mend, it was a highlight of a busy fashion day. SEE THE MAISON MARTIN MARGIELA SHOW ARCHIVE Jessica Bumpus Continue reading Back to top


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If you have strong morals, self-discipline, and a commitment to public safety, one of Schoolcraft's two criminal justice associate in applied science degrees can help you prepare for quick advancement in the field. The first degree is geared toward working professionals looking to enhance their onthe- job training with specialized criminal justice courses and classwork in communications, computing, health, and human relations. This degree will help you develop the skills needed to investigate human behaviors and take the appropriate measures to ensure the safety of society.
The second degree is aimed at students aspiring to law enforcement careers and who want police academy experience, in addition to the academic credentials. After completing the academy, you will be eligible to take the Michigan Commission on Law Enforcement Standards (MCOLES) Certification Exam, which is a prerequisite for employment in this state. Students pursuing a career as a law enforcement officer should review "Employment Standards for Michigan Law Enforcement Officers" at www.michigan.gov/mcoles prior to beginning this area of study, to ensure that they meet certain psychological and physical requirements.


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Stroke Health Center
Bleeding Strokes May Be Preventable
May 22, 2003 -- One of the most deadly types of stroke may actually be preventable among the young and middle-age people it most frequently strikes. A new study suggests that lifestyle changes like quitting smoking, avoiding illicit drug use, and getting high blood pressure under control can substantially reduce the risk of subarachnoid hemorrhage, or bleeding strokes.
Researchers say subarachnoid hemorrhage accounts for only about 3% of all strokes, but it is among the most deadly types of stroke. SAH occurs when a blood vessel on the brain's surface ruptures and bleeds into the space that surrounds the brain. The resulting strokes often happen without warning and are fatal in up to 50% of all cases.
To see what factors might increase the risk of subarachnoid hemorrhage, the study compared lifestyle and health factors among a group of 312 people between the ages of 18 and 49 who had this type of bleeding stroke to a similar group of 618 healthy adults. The results appear in the May 23 issue of the Stroke: Journal of the American Heart Association.
Researchers found major differences between the two groups. Those who had suffered a subarachnoid hemorrhage were much more likely to be smokers, have high blood pressure, or have used cocaine in the last three days than the others.
"One of the study's key findings is that two-thirds of the people who had a subarachnoid hemorrhage in this age group were current cigarette smokers. That is a huge number," says researcher Joseph P. Broderick, MD, professor of neurology at the University of Cincinnati in Ohio, in a news release. "If you're a smoker in this age group, you are about 3.7 times more likely to have this type of stroke than if you're not a smoker."
Researchers say this is also the first study to link cocaine use to an increased risk of bleeding stroke. Although only 3% of stroke victims reported cocaine use, none of the people in the healthy comparison group had used cocaine.
High blood pressure was another major factor associated with subarachnoid hemorrhage. Stroke patients in the study were more than twice as likely to have high blood pressure than others.


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Saints Row 4 Interview with Jim Boone – Audio
After a presentation showing off some of the ridiculously wacky things we're due to expect from Saints Row 4, we got the chance to sit down with Jim Boone, Senior Producer at Volition, to ask him some questions.
In the interview we discuss inspirations, aliens and super heroes, how the development has focused around building the open-world, multiplayer, DLC and more.
We would like to thank Arthur Tolmie from Xtreme Gaming for his great questions during the interview.
You can also read the interview here: Part 1 / Part 2
Not an iOS user? That's OK, just whack our RSS feed into your podcasting thingy of choice and you'll be good to go.


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Posted by Sandy on 9/26/2006, 8:42 pm, in reply to "Making Nova Sys Inc, MIDI 616 work with DMX-4"
That pin out description makes me think it is probably a Microplex (or variant) protocol device not DMX.
Without D+ and D- it certainly is not DMX .
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Hotels in Titisee
- Approximate price: Cheapest | Luxury
- Stars: 1 star | 5 stars
- First name: A-z | Z-a
- Central: More central | Less central
- Services: More services
- User evaluation: Best rated
- BestSelling: Most popular
Maritim Titisee
Seestraße 16, 79822 Titisee, Germany
Maritim Titisee
Titisee, 502 m from the city centre. Seestraße 16 see on map
This 4 star hotel is located in the city centre of Titisee Neustadt and was established in 1980. It is a short drive away from the...
This 4 star hotel is located in the city centre of Titisee Neustadt and was established in 1980. It is a short drive away from the Feldberg. The Hotel has a restaurant, a coffee shop, an indoor swimming pool and a fitness centre/gym. All 130 rooms are equipped with minibar and hairdryer.
Accommodation facilities
- Lift
- Bar/Café
- Meetings Room
- Garage
- Children's Playground
- Internet Centre
- Garden/Terrace
- Laundry
- People with reduced mobility access
- Non-smoker Rooms
- Parking
- Restaurant
- 24 hr Room Service
- Shops
Leisure facilities
- Billiards
- Gym
- Massage
- Swimming Pool
- Sauna
Standard Room Services
- Safe
- Minibar
- Pay TV
- Radio
- Hairdryer
- Telephone
The preferred airport for Maritim Titiseehotel is Basel (BSL-EuroAirport) - 57.2 km / 35.5 mi. Distances are calculated in a straight line from the property's location to the point of interest or airport and may not reflect actual travel distance. Distances are displayed to the nearest 0.1 mile and kilometre.from €87
Approximate price
Bruderhalde, 21, 79822 Titisee, Germany
Titisee, 1.4 km from the city centre. Bruderhalde, 21 see on map
This hotel is by the titisee lakeBreakfast, lunch and dinner are available at this propertyThis is a traditional buildingThis hotel has a...
This hotel is by the titisee lakeBreakfast, lunch and dinner are available at this propertyThis is a traditional buildingThis hotel has a medium size lobby2010 and 2012 the Hotel Alemannenhof was extensively renovated in three construction phases. All guest rooms were upgraded, the lobby expanded, the reception area re-designed
Accommodation facilities
- Lift
- Garage
- Nursery
- Children's Playground
- Garden/Terrace
- Laundry
- People with reduced mobility access
- Non-smoker Rooms
- Parking
Standard Room Services
- Safe
- Minibar
- Satellite TV
- Radio
- Hairdryer
- Telephone
- Television
Leisure facilities
- Disco
- Massage
- Swimming Pool
- Sauna
- Solarium
The Alemannerhof is located on an open hillside with spectacular views over the Titisee. It is set back from, and below, a small road which leads into the quaint centre of Titisee village a short walk away. 1 kms to city centre 120 kms to the airport (zurich airport) 60 kms to the airport (euroairport basel-mulhouse-freiburg) 1 km to the nearest station (titisee) 5 minute walk to the nearest bus stop 30 km to the nearest fair site (freiburg)
Am Kesslerberg 6, 79856 Titisee, Germany
Titisee, 3.5 km from the city centre. Am Kesslerberg 6 see on map
This charming family-run hotel is a very nice place to stay and typical for the area of the Black Forest. It offers guests 14 rooms in...
This charming family-run hotel is a very nice place to stay and typical for the area of the Black Forest. It offers guests 14 rooms in total, as well as facilities including a hotel safe, breakfast room, WLAN Internet access, a car park and bicycle hire service.
The rooms come with balcony or terrace and all rooms dispose of an en suite bathroom with shower, toilet and hairdryer, as well as a double bed, minibar, cable TV and safe. Other in-room amenities include a radio, Internet access and individually regulated air conditioning and heating.
Golfclub Hochschwarzwald is just a 10-minute drive from the hotel.
Leisure facilities
- Bicycle Hire
Standard Room Services
- Minibar
- Satellite TV
- Radio
- Hairdryer
- Television
This family-friendly ski hotel is located in a quiet area where there is very little traffic. It lies within a health resort near the forest with walking trails beginning directly behind the hotel. The area is also ideal for cross-country running and mountain biking, and a 15-minute walk will take guests to the centre of the village of Hinterzarten. Restaurants, bars, pubs, links to the public transport network (bus and train stations) and shops can all by found within a 15-minute walk of the hotel, while a little further afield guests can go to Freiburg (30 minutes on public transport), or Europa Park Rust and Lake Constance which are both an hour's drive away. The Feldberg/Rinken skiing areas are also nearby, just a 20-minute drive from the residence.
From Freiburg, take the B 31 to Hinterzarten. In Hinterzarten, head in the direction of 'Ski Museum' and take the first road to the right after the Ski Museum. Then turn right again to reach the hotel.
Gästehaus Waldeck
Parkstrasse, 4-6, 79822 Titisee, Germany
Gästehaus Waldeck
Titisee, 340 m from the city centre. Parkstrasse, 4-6 see on map
We would like to cheerfully welcome you to the Gästehaus Waldeck. Spa Hotels are plentiful, but this one is a prime example of its type....
We would like to cheerfully welcome you to the Gästehaus Waldeck.
Spa Hotels are plentiful, but this one is a prime example of its type. It has all of the advantages you would expect, and more.
It doesn't matter whether you're staying for one night or more, you will find ample parking spaces available at the comfortable hotel.
Located at our hotel are car parking spots for the benefit of our guests.
Free for you
We provide guests with a complimentary bottle of water.
One of the hotel courtesies is a complimentary newspaper delivered day-to-day.
You can use the hotel sauna for free.
If you are arriving by car, we have free parking directly at the hotel.
Take advantage of the hotel's in-house eatery and café - bistro.
Where you will stay
Our hotel's guests are supplied with their own minibar storing cold refreshing beverages, TV (cable) and easy-to-use landline that are available in each room.
The hotel rooms are outfitted with a safe.
You will also find a radio in each and every hotel room.
All the rooms at our hotel feature a bathroom with a shower. Once you're finished showering grab your bathroom's hand-held blow-dryer to dry your hair quickly.
The windows in each of the hotel's rooms are sound proof.
Relax or be active
Find peace and relaxation in the jacuzzi and sauna.
Ask our talented staff about the sauna included. A steam bath can also be used.
During your visit take part in some of the leisure activities, such as a friendly game of table tennis with your friends and family.
You can also use the walking paths provided in the hotel. They are a real favourite among our hotel's guests.
Business hours of reception:
On business days: from 07:30 to 21:00 and from 07:30 to 21:00
On the weekend: from 07:30 to 21:00 and from 07:30 to 21:00
Standard Room Services
- Safe
- Minibar
- Radio
- Hairdryer
- Telephone
Accommodation facilities
- Garage
- Garden/Terrace
- Non-smoker Rooms
- Parking
Leisure facilities
- Massage
- Swimming Pool
Erlenbruck 5, 79856 Titisee, Germany
Titisee, 3.1 km from the city centre. Erlenbruck 5 see on map
Visit TitiseeEnjoy your stay in Titisee. Make your visit to Titisee an unforgettable experience by staying in the hotel you deserve. Still don´t know where to stay? At Destinia we offer you a wide variety of hotels in Titisee, Germany, so you can choose the one that´s right for you, depending on your expectations and your budget. There are numerous hotels in Titisee that are ideal for a business trip, a family holiday, a weekend getaway or an outing with friends in Titisee. No matter the reason for your trip, at Destinia, you´ll find the greatest variety of hotels and hostels, always at the best prices, guaranteed. Are you looking for a deluxe hotel in Titisee city centre with a spa, Internet access or a pool? Perhaps a hotel that accepts pets or that has a child-care centre? We have that, too. Why not give our hotel finder a try? It´s quick, simple and the most effective way to find the best lodging in this part of Germany. Whether you need a single-occupancy room, double-occupancy room or even a suite, with Destinia´s search engine, you´ll always find the best deals, so all you´ll have to worry about is packing your bags and enjoying your trip to Titisee.
Hotels by category
In Titisee we will have clear sky, a rise in temperature is expected; dress in soft clothing.
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- Isla Cristina
- El Puerto de Santa Maria
- Las Palmas de Gran Canaria
- Corralejo


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Client Drops KPMG, but Not Over Insider-Trading Scandal
KPMG LLP has lost what is believed to be its first audit client since the Scott London insider-trading scandal broke, though the move had nothing to do with the scandal.
Plymouth Opportunity REIT Inc., a Boston-based real estate investment trust, said in a regulatory filing Thursday that it had dismissed KPMG and selected another firm, Braver PC, as its new auditor. A study of filings over the past few weeks shows no other company has switched from KPMG since the London scandal.
London, a KPMG partner in Los Angeles, was implicated earlier this month in passing tips about KPMG clients to a friend who authorities say made $1.2 million by trading on the information. KPMG promptly fired London and called him a "rogue partner," and London, who now faces criminal and civil charges, has said the firm had no involvement in his actions.
Still, market observers have been curious to see whether KPMG would pay a price for the affair among its clients, especially in the Pacific Southwest area where London supervised KPMG's audit practice.
So far, it appears the answer is still "no."
Jeffrey Witherell, Plymouth's chief executive, said in an interview that the company's decision to dismiss KPMG "had no relation" to the London affair. None of KPMG's dozens of Pacific Southwest clients have dropped the firm, and some have publicly reaffirmed their support for KPMG.
Companies do change auditors in the usual course of business, and it was all but inevitable that sooner or later a client would drop KPMG, with or without the London affair. Twenty-two audit clients dismissed KPMG last year, according to figures from AuditAnalytics.com, a consulting firm.
KPMG didn't immediately provide any comment about Plymouth's move. In the wake of the London affair, KPMG has resigned from two clients Herbalife and Skechers USA, and reached out to other clients to reassure them that London didn't access confidential information about them. Last week, the firm said its clients have been "overwhelmingly supportive" of the actions it's taken.
Plymouth paid KPMG a total of $261,905 in fees in 2012, the company said in its annual report.


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[ON NOW] Join GameRevolution's Halo 4 Community Playdate This Weekend!
Posted on Saturday, November 10 @ 12:00:00 PST by Daniel Bischoff
[Update] Below in our community playdate details, you'll find a list of fellow Revolutionaries! Make sure you add everyone before Saturday and start getting a feel for what their brains look like when you shoot at them.
[Original] Are you lining up at midnight? Are you already sitting freezing outside of your local Gamestop? Are you... in Alaska and won't get the game until this weekend?
Well, then perfect timing! I'll be playing Halo 4 online on Saturday at 12 Noon PST. We can play Spartan Ops, Infinity Slayer, Big Team Battle, or maybe some campaign co-op! If you want to join in, make sure you add my gamertag to your Xbox Live friends list. Simply send a friend invite to danielrbischoff and make sure to let me know that you're from GameRevolution.
Also, be sure to add each other! Drop your gamertag in the comments and be sure to add other revolutionaries to your list! See you online this weekend (through my DMR's sights, of course).
What: GameRevolution's Halo 4 Community Playdate
When: Saturday, November 10th, 2012 @ 12PM PST (3 PM EST)
Where: Xbox Live
Why: Headshots.
GameRevolution - Gamertag
danielrbischoff - danielrbischoff
sg4real - XzXDiab1oXzX (spelt with a ONE in place of L)
UghRochester - Here is Howard
gunseedam - NeKo35
Lok-Nar - DoomWolf
madster111 - chickin11
Green_Lantern - Dr Orph3us
MattAY - BarnesBoar
The_Big_Cheese - Big Cheese1987
TheDiesel - Dheziel
Spartan317 - Godlikenative
used44 - AKMitchell
DaveRabbit - Dave Rabbit
drathbone - C0d1esel (spelt with a ZERO in place of O and ONE in place of I)
Noritama - Ronin Zaiber
kingg5 - PDepartment
Optimus-Crime - Wrexx 360
Fieperskaivu - Fieperskaivu
Guernica - Guern88
spartan117cxvy - IronClad Man
Jedi_On_Acid - Jedi On Acid
Rich-Boi07 - L SPARTAN 117 L
(Note: Some of these folks merely expressed interest in play Halo 4. If you don't have the game yet, please let me know and I'll remove you from the list. Either way, everyone should add each other. Peer pressure makes people buy things.)
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Carolyn's Lavender Lemon Verbena Potpurri
Yield varies
The clean, lasting fragrance of this potpourri doesn't require fixatives or fussing. It's simple, keeps its scent until the next season, and looks lovely in sheer, purple-toned gift bags. Two lavender plants (Grosso de Provence and Fat Spike Dutch) and one lemon verbena plant will give me enough material for about two dozen 4.5-by-7-inch potpourri bags. The secret is to dry the lavender and lemon verbena completely.
Equal parts lavender buds and lemon verbena leaves
Dried rose petals, if available
4.5 x 7-inch potpourri bags
1. Cut lavender stems when they are still in bud with a few open flowers. Lie flat in a cool, dark place with good air circulation.
2. Harvest lemon verbena stems with few flowers. Spread flat in a cool, dark place with good air circulation.
3. Remove buds from the lavender and leaves from the dried verbena stems. Toss together with rose petals, if you're using them. Pack into potpourri bags.
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Cake Wrecks – Baby Shower Edition/
I love Cake Wrecks and if you haven't checked out the site, then get over there because it's like lucite stripper shoes – sometimes tacky, sometimes scary and always awesome.
I asked Jen if I could pull a couple of the shower cakes for a post, you can imagine how thrilled I was when she said "go for it".
Let me tell ya, I was not disappointed in the plethora of batshit cakes that people serve up at baby showers.
Here are just a few that are as tasty as electric-blue, store bought frosting:
"What? I thought it was spelled "Tschower". Godammit. Hand me that rag, would ya?"
I love Babbies. The more 'b's the better. (Unless it's actually 'Baffies'. Now that would be stupid.)
"Just a sliver of giant tit for me, please. I'm trying to watch my weight."
Nothing says "edible" quite like an abdomen gash with a hand sticking out.
This is actually a really beautiful cake until you realize you have to cut into a sleeping infant. No, that's not disturbing or anything.
Again, we have to cut this cake, people. I don't want to eat half of a baby's face (judging from the photo, I'd eat the whole head but I wouldn't be happy about it.)
Why do I feel like it was the 18-year-old brother's job to get the cake?
It is important that we all know why we are gathered here today. Stick lady + cup of sperm = heart, baby, heart. All together now...
I'm really hoping this isn't what Tristan looked like. If it was, then my bad and I tip my hat to your charming cake.
WTF is happening here? Why is a burnt ET sitting on top of a t.v.? Welcome to the world, Ethan. You're surrounded by nuts.
Maybe the parents decided to name this child "Finally" regardless of gender because I can't even figure out what they were going for here.
Oh, it's a baby BABY shower. Crap, I need to get another card.
I have no idea what they find weird about this cake?! Maybe the woman they were having the shower for wasn't named Olivia. Now *that* would be awkward.
Actually, this is exactly how Connie gave birth – surrounded by rosettes while her giant boob-balls rolled into her mouth.
Yes, congratulations on your headless baby, now let's eat its feet.
Mmmmm, uterus.
What you can't see is Uncle Bob's interpretive dance that goes along with this cake. It's all about learning through poetry and movement.
Is it worse to eat a beautiful baby cake or a creepy one? Creepy cake babies have rights too, you know.
This is possibly the best cake I have ever seen. If I had witness this cake in 1977, my head would have exploded or I would have done something like this. With the protection of Darth Vader in an acid tripping, air-brushed universe, that lucky little baby can't lose. She just can't lose.
This isn't even a cake but I am horrified that someone has taken the two things I love most – meatloaf and bacon – and molded it into the most disturbing thing I have ever seen. Excuse me while I go bleach my eyes.
So there you have it. Now get out there and get your creepy "babby" cake holding a cup of sperm and some bacon. Happy showers, Peeps!
Oh but wait, there's more. It gives me such joy to think you guys see a crazy ass baby shower cake and think of me. Here's a couple you've sent that I think are just magic:
Golly that's a lot of detail -- "Grandma, can I interest you in a slice of taint?"
After I got over the initial shock of these cupcakes, I decided they were awesome like a cat playing piano. Gimme two!
Wow. Just wow. This cake is so entirely awesome that I can't handle it. First I saw the head. Nice. Then I saw the strawberries. It really is an art to make strawberries disturbing. Then, and only then, did I happen to notice the sprinkles for the asshole.
This truly is a cake of many layers.


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Featured Girl
Welcome to the Mystic Kisses website where we proudly present our large and always growing selection of female companions.
Welcome to the Mystic Kisses website, where we proudly present our large and always growing selection of female companions. Mystic Kisses is a premiere escort service serving clientele in the Tampa, St. Petersburg, and Clearwater areas. We specialize in bringing quality people together for a fresh, sexy, and unique experience.
At Mystic Kisses, you can always find a perfect match for any occasion. We feature Tampa, St. Petersburg, and Clearwater escorts that love providing one-on-one sessions, some take pleasure in entertaining couples, and others enjoy specializing in fantasy and role playing. A diverse group of girls are offered to you like both Black and White American girls, Asian, Latin, and European. We have a wide variety of ladies available 24/7 both on and off of our website. We will gladly spend any amount of time over the phone providing honest and accurate descriptions for all of them.
One of the best parts is that you'll never have to worry about dealing with anyone that's less than reputable, unreliable, or overpriced that charges outrageous rates just because they think they can. Whether you're traveling here on business, vacation, or if you live here locally in the bay area, just think of Mystic Kisses as your trusted advisor, and we will be sure to provide you with the most attractive and exciting escorts with an insatiable appetite to please you.
We always want you to relax and let our lovely Tampa escorts, St. Petersburg escorts, and Clearwater escorts show you all the best of first-class service. You will enjoy the never-ending pleasure with the most beautiful ladies who are elegant, charming, and above all, truly yours.
A quality experience is what you can always expect, because we deliver the highest level of service possible. Our services are nothing less than impeccable; from convenient booking and prompt arrival, to the pleasure and discretion of your session, Mystic Kisses provides only the best for our clients. We offer the finest selection of girls to choose from, and all sessions are tailor-made for a personal touch.
We guarantee a discreet, relaxing and pleasurable atmosphere at all times, and pride ourselves on our reputation as a first-class agency. Our Tampa escort services, St. Petersburg escort services, and Clearwater escort services set our well-known standards of excellence throughout the industry. One of the ways we uphold these standards is that we selectively hire all of our girls that not only possess glamorous good looks, but they also all have a golden personality to equally match.
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With Mystic Kisses, you will spend quality time with a special companion that will make you feel truly amazing throughout your session. Your session will never be rushed; from the moment you meet one of our girls, you will always remain the focus of her sensual attention so that you can savor every second of your exclusive time together.
You will thoroughly enjoy her company as she introduces you to a luxury of feelings that will sweep you away on a pink cloud of pure heavenly pleasure. When our escorts delight you with their uncanny ability to anticipate your every need, you'll experience firsthand why we are the leading Tampa escort service, St. Petersburg escort service, and Clearwater escort service. Our sensually gifted companions will indulge you with an erotic escape in which you can connect and feel free to express all of your thoughts and desires.
Your pleasure and enjoyment is each girl's ultimate goal, which becomes evident as you have the most amazing girlfriend experience that will leave you with sweet sensuous memories long after your session is complete. So whenever you're looking to treat yourself to something special, give us a call and let us impress you with the best of our Clearwater escort services, St. Petersburg escort services, and our Tampa escort services.


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TASER International (Nasdaq: TASR ) reported earnings on July 31. Here are the numbers you need to know.
The 10-second takeaway
For the quarter ended June 30 (Q2), TASER International beat expectations on revenues and beat expectations on earnings per share.
Compared to the prior-year quarter, revenue grew. GAAP earnings per share increased significantly.
Gross margins increased, operating margins contracted, net margins increased.
Revenue details
TASER International reported revenue of $32.2 million. The three analysts polled by S&P Capital IQ expected to see revenue of $31.0 million on the same basis. GAAP reported sales were 14% higher than the prior-year quarter's $28.2 million.
Source: S&P Capital IQ. Quarterly periods. Dollar amounts in millions. Non-GAAP figures are normalized by S&P Capital IQ and may vary to maintain comparability with normalized estimates.
EPS details
EPS came in at $0.08. The four earnings estimates compiled by S&P Capital IQ averaged $0.07 per share. GAAP EPS of $0.08 for Q2 were 33% higher than the prior-year quarter's $0.06 per share.
Source: S&P Capital IQ. Quarterly periods. Non-GAAP figures are normalized by S&P Capital IQ and may vary to maintain comparability with normalized estimates.
Margin details
For the quarter, gross margin was 61.4%, 290 basis points better than the prior-year quarter. Operating margin was 21.2%, 30 basis points worse than the prior-year quarter. Net margin was 13.9%, 170 basis points better than the prior-year quarter. (Margins calculated in GAAP terms.)
Looking ahead
Next quarter's average estimate for revenue is $32.8 million. On the bottom line, the average EPS estimate is $0.08.
Next year's average estimate for revenue is $128.7 million. The average EPS estimate is $0.28.
Investor sentiment
The stock has a two-star rating (out of five) at Motley Fool CAPS, with 1,000 members out of 1,090 rating the stock outperform, and 90 members rating it underperform. Among 190 CAPS All-Star picks (recommendations by the highest-ranked CAPS members), 166 give TASER International a green thumbs-up, and 24 give it a red thumbs-down.
Of Wall Street recommendations tracked by S&P Capital IQ, the average opinion on TASER International is outperform, with an average price target of $11.17.
Looking for alternatives to TASER International? It takes more than great companies to build a fortune for the future. Learn the basic financial habits of millionaires next door and get focused stock ideas in our free report, "3 Stocks That Will Help You Retire Rich." Click here for instant access to this free report.
- Add TASER International to My Watchlist.


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Benign tumors are a common manifestation of tuberous sclerosis complex (TSC). Heart tumors that result from TSC are called cardiac rhabdomyomas. As their name suggests, rhabdomyomas are composed of tissue normally present in the heart (rhabdo), that grows in a disorganized mass (myoma). In this way they resemble other types of a general class of TSC-related tumors, called hamartomas.
Unlike hamartomas that occur in other organs, cardiac rhabdomyomas are most prevalent in infants and very young children with TSC, and become less prevalent with age. In fact, cardiac rhabdomyomas are the only TSC lesions known to regress over time, in some cases disappearing entirely between early screenings and subsequent examinations. Still, in rare cases of particularly large or numerous tumors, they can disrupt heart rhythm or blood flow through the heart, causing physical impairment and possibly death. Because of this and because cardiac rhabdomyomas provide a critical early sign in the diagnosis of TSC, it is important for doctors to assess heart anatomy and function in individuals suspected of having the disorder or in those previously diagnosed.
In this video, pediatric cardiologist Ana Maria Rosales provides an overview of how TSC can affect the heart. [duration 1:38]
Show Video | Read Transcript
Cardiac rhabdomyomas are the earliest detectable clinical indicator of TSC. In some cases, they are identified during prenatal screenings by mid second trimester and can lead to early diagnosis. Approximately 47 to 67 percent of people with TSC have cardiac rhabdomyomas. More importantly in terms of diagnosis, at least 50 percent and possibly a much higher percentage of children with documented rhabdomyomas are ultimately diagnosed with TSC. Because of this diagnostic significance, cardiac rhabdomyomas are considered a major feature in the diagnostic criteria of TSC.
In most people, cardiac rhabdomyomas are small (5-15 mm in diameter) and have no effect on heart function. However, in rare cases where tumors are particularly large or grow on or near heart valves, they can have dramatic effects. Such tumors can obstruct blood flow, impair valve function, or disrupt electrical activity in the heart causing an abnormality of the heart rhythm called an arrhythmia. Although these malfunctions are rare—causing heart failure in just 2 to 4 percent of children with cardiac rhabdomyomas—they are significant and should be evaluated by a pediatric cardiologist.
To detect cardiac rhabdomyomas, doctors use a high-resolution form of ultrasound called an echocardiogram. Cardiologists recommend this exam for all people, especially infants, diagnosed with the disorder and in cases where there is a high suspicion of TSC. They may also recommend a prenatal echocardiogram in cases where parents or immediate family members have TSC. Often, an electrocardiogram (EKG), a reading of the heart's electrical activity, is paired with an echocardiogram to rule out disruptions in heart rhythm that may be caused by a cardiac rhabdomyoma.
Follow-up and Treatment
Once cardiac rhabdomyomas are identified, doctors typically monitor them periodically to ensure that they are regressing. After regression is confirmed, it is seldom necessary for people with small tumors and no detectable heart dysfunction to seek regular heart exams. However, the use of two widely used medications in TSC may make regular screenings necessary. One of these, called adrenocorticotropic hormone (ACTH), commonly used to control infantile spasms, has in rare cases caused cardiac rhabdomyomas to enlarge. Another medication, Tegretol, used to control epileptic seizures in people with TSC, may affect heart rhythm. TSC specialists recommend that before people begin these treatments they undergo an echocardiogram and EKG to establish baseline readings, and then seek regular screenings thereafter.
Cardiac rhabdomyomas are rarely treated because few have significant effects on heart function and most regress over time. However, in rare cases where large cardiac rhabdomyomas impair heart function, cardiac surgeons may surgically remove the offending tumor or tumors.
Next Steps
It is important to remember:
- TSC often causes benign tumors to grow in the heart.
- These tumors, called cardiac rhabdomyomas, occur in most people diagnosed with TSC.
- Cardiac rhabdomyomas are most prevalent in infants and young children because the tumors typically regress with age.
- In most people with TSC, cardiac rhabdomyomas have no effect on heart function.
- Large or numerous cardiac rhabdomyomas can affect heart rhythm or blood flow through the heart.
- In very rare cases, it becomes necessary to surgically remove problematic rhabdomyomas.
- In most cases, TSC specialists simply monitor cardiac rhabdomyomas to ensure that they are regressing, and patients rarely need to follow up after that.
- TSC specialists usually recommend that immediate family members of individuals diagnosed with TSC undergo screening for cardiac rhabdomyomas because the tumors serve as indicators of TSC and can aid in diagnosis.
Relevant Specialists
A cardiologist is a physician who is certified to treat problems of the cardiovascular system, including the heart, arteries, and veins. Cardiologists are trained to recognize cardiac rhabdomyomas and to assess the effect of these tumors on heart function and on the overall health of their patients. Infants and children with TSC may see a pediatric cardiologist.
You can find a list of on-staff physicians on the Herscot Center for Children and Adults with TSC Web site.


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The Metropolitan Transit Authority will start its Park & Ride service early today, at 1 p.m., to accommodate commuters with early work dismissals.
The Park & Ride buses will be running about every half hour until the start of the regular Park & Ride schedule. Street supervisors will be on hand to assist customers.
Metro also is continuing to offer warming vehicles at 20 transit centers until Friday afternoon or as weather conditions dictate.