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No matter your location, when you think of spring, you probably think of color. And for those of you (like us) who happen to live in a part of the world in the midst of a gray, cold winter, I think it's fair to say we look forward to Spring just a bit more than the average person.
Earlier this week we introduced you to Glossi, a website where anyone can put together their own online magazines. One of the great things about Glossi is that there is so much flexibility. If you had a chance to flip through the Fall 2012 Textures Glossi we shared on Monday, you probably noticed that we were able to share the same information that you would get from a regular magazine, but with the added bonus of having the products just a click away.
We love having the opportunity to work with other amazing sites around the interwebs and do it as often as we can. This time, we're working with an awesome new site called Glossi.com, which mixes personal publishing with social media.
You might remember reading a few weeks ago about an awesome jewelry event that we were planning with the Rebecca Minkoff team. While it was unfortunate that we had to postpone due to Hurricane Sandy, we have some exciting news: We've rescheduled the event!
Today is one of those really nasty and gross days. You know the kind; they suck out any motivation you might have had to be productive. These kind of days are the ones that encourage staying in, watching a movie (preferably a great RomCom, obviously) and ordering in dinner.
Ladies and gents, the time has come: we have ourselves a winner. As many of you know, we partnered with our fabulous friends at PopSugar, Moda Operandi and Shop Style to give all you handbag fanatics the opportunity to win a vintage 35cm Navy Hermes Birkin.
I have to say, when it comes to handbags, the PurseBlog team tends to influence one another pretty frequently. Well, it's happened again. A few days ago, Amanda covered Kelly Osbourne carrying a neon Chanel Flap over on BagThatStyle.
You know, there's something thrilling about coming across bags that fall into the pre-order category. Now don't get me wrong, anything that is pre-order can also make my eye twitch while simultaneously making me want to pull out my hair.
Last week, I wrote about these really cool Must Have Boxes that our friends at PopSugar put together every month. It's such a cool concept! Each month you know you will be getting a great box filled with all sorts of amazing items, but you don't know what they are.
By now, I am sure some of you out there are familiar with the lifestyle site Joyus. It's a fun, interactive, video-based site that lets viewers see items they may want to buy in motion. You know those times where you see an item online, even on a model, but aren't exactly sure what it would look like on a moving, breathing human being like yourself?
We love partnering with our friends at PopSugar! This time, nothing will help get you through your mid-week hump better than some really fun news. PopSugar has put together these amazing monthly Must Have boxes and is offering them to the PurseBlog family at a discounted price… or free, if you're lucky!
One of the bags I think about the least but probably get the most use out of is my cosmetic bag. I use it daily, it travels with me and, quite frankly, I don't take very good care of it.


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Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Perfume Worldwide, Inc at the time of purchase will apply to the purchase of this product.
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Introduced by the design house of Dolce & Gabbana in 2001. This is classified as a flowery fragrance. This feminine scent possesses a blend of rose, apple, musk, and jasmine. It is recommended for casual wear.. Price: $56.99
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Modern Community / Cafeteria
In this section, our firm brainstormed the ideas on how to remodel the Mira Loma cafeteria.
Our director of landscape design is using the following materials and design inspirations:
• Alstroemeria, lilies, lisianthus, tulips, and poppies; these flowers mostly grow year round.
• Water source; the landscape designer that came to talk to us has inspired us, and that way we can reuse rain water to water the plants.
• Solar panels around the top sides of our roof building, to give power to the water filter and some of the lighting in the building.
• Elevator for ADA purposes.
• The soil from the plants will cool down the building.
Our director of interior design is using the following materials and inspirations:
• Surface for all tables; all surfaces are paperstone. The company that inspired us was CaraGreen.
• Lighting; energy efficient by Energy Star company.
• Toilets; for solid waste is 1.6 gallons and for non-solid waste is 0.76 gallons inspired by Toto Aqua company.
• Stainless steel for kitchen fridge, ovens, and stove by Traulsen company.
• Tiles for bathrooms are made from post consumer recycled waste, granite dust and glass cutting operations by Fire Clay Tile Company.
• Flooring; The floors are going to be granite by the Aldon company.
Our director of sustainable energy and resources is using the following materials and inspirations:
• Solar panels; saves energy.
• Water collectors; inspired by the guest speaker.
• Windows; reduce the amount of energy needed to light up the space.
• Glass; low-E - it has clear coating of metallic oxide.
• Garden on the roof and waterfall cools down the building.
Our director of building design is using the following materials and inspirations:
• Concrete for the structure
• Steel is used for the building's frame and as a support
• Glass
• Aluminum
• Bricks
Our director of community relations has reserved the building for the following groups and activities:
• Seniors and grownups
o teach cooking classes
o participate in cooking contest
• Teenagers
o learn how to cook
• Teachers
o use second floor stage for conferences
• Mira Loma High School
o use the stage for different events such as senior ball, junior prom, homecoming, etc...
• High School Bands and Guest bands
o can perform during lunch or have different concerts


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Byram man killed in Madison County crash
Camry runs off road, hits tree
Published 11:08 AM CST Jan 17, 2013
A Byram man was killed Wednesday night in a Madison County car crash, state officials said.
The crash happened at 10:39 p.m. on Highway 43 near Sharon, the Mississippi Highway Patrol said.
A black 2006 Toyota Camry driven by Pierre Fields, 27, was traveling south, ran off the road to the right, overturned and hit a tree, MHP said.
Fields was pronounced dead at the scene, officials said.
The crash remained under investigation on Thursday, MHP said.
Copyright 2013 by WAPT.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Average retail gasoline prices in Mississippi have risen three cents per gallon in the past week, according to GasBuddy.com. It averages $2.68 per gallon as of Monday.
The average price in Alabama is $2.70 per gallon for regular unleaded.
The Web site put the national average up 3.6 cents per gallon in the same time period, averaging $2.78 per gallon.
Since last year, the price has increased almost 91 cents a gallon, and is 21.8 cents per gallon higher than a month ago.
"We're starting off March like a lion with little hope of it going out like a lamb", said Patrick DeHaan, GasBuddy.com senior petroleum analyst. "While conventional wisdom tells us demand will increase as we move towards warmer weather, it appears that gasoline price increases have easily outpaced any potential increases in demand thus far."
DeHaan said he expects most of the country to flirt with prices near or over $3.00 per gallon by Memorial Day, with the exception of California, where prices will average near $3.35 a gallon.
DeHaan said the bright spot is that plenty of spare refining capacity and lower gasoline demand than in previous years will keep gasoline prices from reaching record highs.


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Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on NORDSTROM.com at the time of purchase will apply to the purchase of this product.
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A vibrant floral print lights up the crisply pleated chiffon of a graceful sleeveless fit-and-flare dress. Color(s): neon yellow combo. Brand: BCBG MAX AZRIA. Style Name: BCBGMAXAZRIA 'Sierra' Floral Print Pleated Dress. Style Number: 629184.. Price: $338.00
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Great bldg site convenient to mall & interstate, public water-Bayou Liberty Water.
Get a detailed community profile report via email. Click here to get your copy right away.
Please fill out the form below and a community profile report will be emailed to you soon!
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McCain Lends Hillary Clinton a Helping Hand
Patrick Yoest reports on Congress.
Sen. John McCain unexpectedly lent a hand to Sen. Hillary Clinton on the Senate floor today, calling for her quick confirmation as secretary of State without a lengthy roll-call vote.
Clinton's nomination has broad support in the Senate, but Republican Sen. John Cornyn of Texas has objected to confirming her without a roll-call vote. Cornyn has voiced concerns about possible conflicts of interest stemming from the global fund-raising efforts of Clinton's husband, former President Bill Clinton, as head of the nonprofit Clinton Foundation.
But McCain, last year's Republican nominee for president, argued that the Senate should skip the time-consuming roll-call vote and confirm Clinton by unanimous consent. "I think the message that the American people are sending us now is they want us to work together and get to work," McCain said.
The Senate could unanimously confirm Clinton this afternoon, before the scheduled vote was to take place.
McCain cited Tuesday's inauguration of President Barack Obama, calling it a "remarkable and historic" event — and a signal that lawmakers should work together. Clinton, he added, is "obviously qualified."
McCain has kept a low-profile since his November loss to Obama, but has enjoyed an unusually close relationship with Obama since the election. On Monday night, Obama held a dinner in McCain's honor, and Obama has recently consulted McCain on foreign-policy issues, including the war in Iraq.
While McCain said he had spoken with Cornyn to receive his approval for skipping the roll-call vote, McCain and Cornyn have had well-documented battles in the past, including a heated exchange in 2007 over immigration legislation.
UPDATE: The Senate early Wednesday evening overwhelmingly voted to
confirm Hillary Clinton as secretary of state, setting aside concerns from some Republicans that she had done too little to distance herself from her husband's
fund-raising activities. Clinton was confirmed by a 94-2 vote, with only Republican Sens. David Vitter of Louisiana and Jim DeMint of South Carolina voting against her appointment.


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a1 Emory University
a2 Emory University
Using data from the 1976–1994 American National Election Studies and the 1992–94 ANES panel survey, this paper demonstrates that the outcomes of the 1994 and 1996 elections reflected a longterm shift in the bases of support and relative strength of the two major parties. This shift in the party loyalties of the electorate was based on the increased ideological polarization of the Democratic and Republican Parties during the Reagan and post-Reagan eras. Clearer differences between the parties' ideological positions made it easier for citizens to choose a party identification based on their policy preferences. The result has been a secular realignment of party loyalties along ideological lines.
(Accepted November 26 1996)
(Received September 01 1997)
Alan I. Abramowitz is Alben W. Barkley Professor of political science, Emory University, Atlanta, GA 30322.
Kyle L. Saunders is a Ph.D candidate in political science, Emory University, Atlanta, GA 30322.


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Pink paddlers to race dragon boats in Sarasota
Published: Monday, July 14, 2014 at 5:03 p.m.
Last Modified: Monday, July 14, 2014 at 5:03 p.m.
SARASOTA COUNTY - More than 100 breast cancer-survivor dragon boat paddlers will descend upon Nathan Benderson Park on Aug. 9 for a day of racing, coaching and mostly practice for the big event.
Dragon boat paddlers from Tampa, Miami and other cities in Florida are hosting an open paddle event at Nathan Benderson Park, 2500 N. Honore Ave., from 9 a.m. to 2 p.m. on Saturday, Aug. 9. The event is free and open to the public. The breast cancer survivors also will be at In the Pink boutique, 1727 Fruitville Road, Sarasota, after the racing events.
About the 2014 International Breast Cancer Paddler's Commission Dragon Boat Festival
• Breast cancer survivors race 22 members to a team, with one woman keeping the cadence by beating a drum at the front of the boat and another steering in the back.
• In the middle of the boats are the rest of the team members, the paddlers, lining each side of narrow 40-foot vessels.
• The dragon boats will race next to each other in a straight line for 500 meters, which takes, on average, 2.5 minutes.
• The festival follows the rules of traditional dragon boat racing, a popular worldwide sport with ancient roots in Chinese culture that emerged as an international sport in Hong Kong in the 1970s.
• Dragon boats can weigh more than 800 pounds empty, and paddlers need significant upper-body strength to compete. Upper-body movement and strength can be limited or weak after a mastectomy, a common procedure in breast cancer treatment.
• While many women train for the events, it is more friendly than competitive.
• The International Breast Cancer Paddlers' Commission formed in 2010.
The August event is a preview of sorts for the 2014 International Breast Cancer Paddler's Commission Dragon Boat Festival, which will draw more than 3,000 paddlers from 10 different countries to Benderson Park on Oct. 24-26.
Tampa's home team, the "Pink Dragon Ladies" worked with Miami's team, "Save Our Sisters," for a bid to host the 2014 event.
The three-day gathering is expected to fill nearly 8,000 hotel rooms in Southwest Florida as breast cancer survivors take to the waters of Benderson Park adorned in symbolically pink paddles, boas, wigs and headbands.
This also is the first time the United States will host the festival, held once every four years.
"Part of the reason why we won the bid was because we proposed an initiative to bring 10 new teams to Florida in 10 years time," said Kim Bonomo, president and co-chair of the Sarasota event. "This is the 10-year anniversary of the first team in Florida, which began in Tampa."
As a part of the bid plan, the Florida-based teams have been working to add to the number of sanctioned teams across the state. They have been using Benderson Park as a hub for education and practice for those new to the sport.
Teams from Sarasota, Punta Gorda, Tampa, Miami, Orlando, Jacksonville and Melbourne are scheduled to attend the test event in Southwest Florida next month.
"A lot of the Florida teams are very new and won't have a lot of opportunity to race before the big event in October," Bonomo said. "This gives them the opportunity to get out on the water and practice as a team."
The Tampa and Miami-based teams hosted a similar event in December at Benderson Park, where participants from all over the state came to take part in an open paddle event.
That gathering was aimed at inspiring local residents to come out and get to know the sport and the cause.
Paddlers will participate in racing and seminars at the park in August. There also will be a reception at In the Pink, a new, non-profit boutique in Sarasota dedicated to helping survivors deal with the effects of breast cancer.
The pink paddlers are partnering with the Mall at University Town Center to be the registration headquarters for the official event in October.
Sarasota County schools also have donated 60 school buses for the event.
"We're really proud of bringing new teams to Florida and generating interest in the sport and our cause," Bonomo said. "It's been a lot of work so far, but it's really gratifying."
Last month, Benderson Development Co. donated two dragon boats, one painted bright pink and named "Nate's Hope." Randy Benderson, president of Benderson Development, christened the boats on June 7, the official opening date of Nathan Benderson Park to the public.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Posted: Tue Mar 01, 2011 11:54 am
Post subject: November 2011 birth club!!
Hi ladies,
I thought I would start the November birth club, it's so exciting my first pregnancy and it's great to share with girls from the TTC forums I have chatted to in the past 2 years.
So far I think we have with dates;
Nelliedean (2nd baby)31.10.11
jadek88 (3rd baby) 2.11.11
Deecee24 (3rd baby) 3.11.11
Bunny 79 (1st baby) 4.11.11
Mrs MB - (2nd baby) 5.11.11
Stalks (1st baby) 5.11.11
ClaireB13 (1st baby) 6.11.11
Penny76 - (1st baby) 7.11.11
Sel79 (1st baby) 6.11.11
Avfc girl 2nd baby 10.11.11
J Jennyx (1st baby) 13.11.11
Gemz2008 (2nd baby) 13.11.11
oxoSummerLeighoxo(2nd baby) 13.11.11
callyann91 13.11.11
Mpat (2nd baby) 15.11.11
AnaCee 17.11.11
Chez100 20.11.11
missjthomas83 23.11.11
snoopya 29.11.11
xxJadexx (2nd baby) 26,11,11
30.11,11 2nd baby
Stacey RD (2nd baby)30.11.11
look forward to chatting with you all soon xx
Last edited by bunny79 on Mon Mar 28, 2011 3:01 pm; edited 11 times in total
Posted: Tue Mar 01, 2011 10:14 pm
Post subject:
Hi ladies thanks bunny. Claire im going to get a test fri and take another. Think if i leave it a few days then do another 1 it will sink in more so no ur not the only 1!
What symptoms is everyone having? Mine is mainly AF like cramps really thirsty and funny test in mouth. Sore boobs on and off xxx
Posted: Wed Mar 02, 2011 7:34 am
Post subject:
Hi I'm just on my phone nie when I'm on the pc will edi the list! I can't get over the sence of worry Its going to b ok I think because we tried for so long does anyone else feel like this? Sure it will pass after first scan!
I'm having sore boobs a lot and niPples are bigger!I
Other than that it's on and off cramps like af and very , very tired!
Cant wait to be able to start telling people I'm going to do another test sat as a week after bfp!!!
Chat soon xxxx
Posted: Wed Mar 02, 2011 1:19 pm
Post subject:
hi i loved to join you ladys im due the 7 november .
im already being sick so wondering if its twins as i had 2 embryos back were know on the 17 march as thats when we have our first scan at 6 weeks because had ivf you get scanned at 6 weeks and 8 weeks and feel tired all time boobs are tender and im weeing for England lol
Our girls are 2 years old 6months
Posted: Wed Mar 02, 2011 4:10 pm
Post subject:
Thanks Staks for making me feel im not obessed with testing, it really doesn't help that had a load of internet cheapies in the house
Have been to the doctors today to confirm pregnancy and have arranged for a 6 week scan on 16th March. Im so relieved that the doctor listened to me and rang the EPU to confirm that they are going to monitor me closly after having 2 miscarriages. Can't wait for the 16 now
Hi Penny, congratulations, have a happy and healthly 9 months
The only syptoms I have is feeling tired all the time, some cramping and tender boobs every now again x
Posted: Wed Mar 02, 2011 4:34 pm
Post subject:
Hi Claire
I am having a 6 week scan the day after you on the 17th March. I agree with the cramping and tiredness my tender bbs are quite sore though should be good signs.
when are you telling friends/familY? we are hoping to tell my folks after 6 week scan on the 17th March. I want to tell everyone! Its hard not to keep worrying after ttc for so long so will be releived when we get the next 2 months out the way
look forward to chatting soon xx
ps all dates so far updated
Posted: Wed Mar 02, 2011 5:12 pm
Post subject:
Hi Bunny,
your having a early scan too, thats good news I know what you mean about getting the next 2 months out of the way.
I have already told my parents and husband told his father. I know is early days and with my history some people would not say anything but I am really close to my mum and we talk on the phone nearly every day (my parents live abroad) and she was actually here on the day I a had my last miscarriage, so its nice to have her surport. I have also told my best friend because she been with me on TTC journey and she asks me every month if I have any news. The only other people I have told is my store manager (im an assistant manager in a retail store) and the 2 team leaders I work with because my job can be very physical moving fixtures etc which I will not do and they would be wondering why. Everyone has been sworn to secrecy though. I will be telling everyone else when I get to 12 weeks x
Posted: Wed Mar 02, 2011 5:20 pm
Post subject:
thats a good plan
my mom and dad were over the moon 2 weeks ago when i told them ivf funding came through and she told too many people/
i am trying to hold out to the 6 week scan so i can then make out we went for ivf appt and then actually tell them we are 6 week pregnant
sorry to hear about your 2 previous mc that must be so hard, i just cant stop worrying after ttc for nearly 3 years i suppose its natuarl
i am praying for us both to have sticky beans and will the days away until we can have our scans
i fell over earlier just on my bum at home as i stood back from wardrobe to sit on otemen to put socks on = think i was just daydreaming and now worrying thats affected things.
have you ttc for long? Its so exciting isnt it?!
speak soon xxxx
Posted: Thu Mar 03, 2011 4:18 pm
Post subject:
Yeaaahhh Im in the same club. Im due on 10th November. How excited. I found out on Friday. Im so excited. I cant work properly, Im just daydreaming all the time.
Hurry up scan day so I can see my 'special one'! Congratulations to you all, lets up the 8 months go with no hitches-Yeaaahhhh!!!!!!
Posted: Thu Mar 03, 2011 6:04 pm
Post subject:
Hi ladies congrats to the ladies that have joined here. H and H 9 months. We are not telling either parents till bout 9wks. Just wanted to wait abit longer as found out so earlier and the other reason is its mothers day the same time. So we are going to buy 2 grandparents cards and write in them something like. To nanny and grampie mummy and daddy have been keeping me a secret for a few weeks. But i want to let u no that i am really looking forward to meeting u around the 5th november. Hope ur happy to know this as mummy and daddy are over the moon. Love u lots ur 1st grandchild.
I also had the midwife ring me today and my 1st apponiment is the 24th march and i will be nearly 8 wks!! Really starting to feel real now and so excited. I hope everyone else is doing ok xxx


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Lagoon cleanup to be done in kayaks
Registration now open
CARLSBAD Batiquitos Lagoon Foundation holds its annual Kayak Cleanup Oct. 5-6 with the first launch 7:30 a.m. and the last launch 3:30 p.m. both days. The event gives kayakers a chance to take a two-hour excursion on the lagoon that is normally closed to boating, and at the same time clean up the lagoon by removing shoreline trash.
Participants can bring their own kayaks or use kayaks and safety equipment provided by REI, the event's key event sponsor. Each group will be accompanied by guides.
Cost: $50; benefits the foundation. Open to age 12 or older.
Visit batiquitosfoundation.org.


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CIS Home >
> News & Services >
Security Analysis Service
In response to the Information Technology Advisory Committee's
recommendations regarding improved network security, CIS
is now offering network-based security analysis of WHOInet
hosts as a consulting service. This service brings you up
to date on the security of your server systems, and gives
you the information you need to verify or improve their
To request a security analysis of your WHOInet-connected
computers, please fill out a Security
Analysis Request Form. Once your computers
have been evaluated, CIS staff will prepare a security analysis
report about them, which will be sent to you in email. This
will include:
A sample
analysis report is available. This is a sample
only, and should not be used as a guide for any particular
actual computer system. The length and depth of real analysis
reports will vary based on the number and kind of services
and vulnerabilities discovered.
Note: Security analysis is a fee-based
service, like all CIS consulting work. It is primarily intended
for the operators of server systems -- computers offering
network resources (Web sites, FTP, etc.) to WHOInet or the
Internet -- and for workstations which might be unintentionally
exposing network resources. While a security analysis may
be useful for all computers, we need to make server
systems our first priority in doing analyses.
If you have any questions about the security analysis service,
please send them to Karl
Krueger. This service is one of several ways CIS is
looking to help improve WHOI's network security, and we
always invite your thoughts on this important matter.


text:
Created a topic, Permissions Error, on the site WordPress Support Forums
5 years ago
Posted a reply to "any way to use bloginfo() to link to uploads directory?", on the site WordPress Support Forums:
@blockbot, thanks, you did explain it better. As is often the case the WP Codex…
6 years ago


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As Radiohead, Adele and fellow Mercury Prize-nominated luminaries hold their breath to find out who will claim this year's gong at tonight's ceremony, surprise nominees the Portico Quartet have already proved financial winners.
Since they were included on the prestigious music prize's shortlist in July, sales of the previously little-known jazz quartet's album Knee-Deep in the North Sea have rocketed 105 percent.
The band's 11 fellow nominees have enjoyed a similar, if not quite so dramatic, rise in popularity. Sales for Neon Neon's album Stainless Steal are up 36 per cent, while The Last Shadow Puppet's Age of Understatement is


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OAKLAND -- A's starting pitcher Jarrod Parker threw on the side before Wednesday's game against the Cubs in the Coliseum and came out of it feeling fine.
Even so, the A's don't want to take any chances with Parker's health, so the cramp in his hamstring will cause the club to push back his start to Saturday in Kansas City.
To take his place on the roster, Dan Straily will be recalled from Triple-A Sacramento and will get Thursday afternoon's start in the series finale against the Chicago Cubs.
"We're going to give him a couple of extra days," manager Bob Melvin said of Parker, who came out of Saturday's game against St. Louis with a hamstring problem. The A's believed at the time it was a cramp and hoped it was not something more serious.
Straily was sent down after his last start when the A's, looking at a streak of three off days in the space of just over a week, decided they weren't going to need a fifth starter for a time.
Oakland opted to go one pitcher short, bringing up catcher Stephen Vogt with John Jaso fight abrasion on his left palm that didn't allow him to swing a bat without pain. Jaso is healthy again and Vogt is likely to head back to Sacramento to make room for Straily.
Jaso spent much of the pregame Tuesday hitting in the cage when he wasn't taking batting practice and pronounced himself ready to go afterward.
Asked about the possible participation in the All-Star home run derby, Cespedes said he'd very much like to have that chance, but said that as yet, no one had approached him about taking part.
Anderson, who has been trying to get healthy after a sprained right ankle was compounded by a stress fracture in the same foot, is due to have his foot examined Friday. If he is cleared, he'd be able to start working toward a return in the second half of the season.
He's been throwing on the side without using his legs to keep his arm strong and cut down the amount of time he'll need building back up to being game-ready.


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Rangers lose 5-2 against the White Sox
Photo: Brad Loper/Staff Photographer
Texas Rangers shortstop Elvis Andrus (1) scoops up a ground ball to make the double play on Chicago White Sox shortstop Alexei Ramirez (10) and Chicago White Sox catcher Tyler Flowers (21) in the 2nd inning of MLB Baseball action at Rangers Ballpark in Arlington, Texas on Wednesday, May 1, 2013.
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Bayou fans travel to Dallas to watch the Saints WIN!!!!!
Published: Friday, January 19, 2007 at 9:22 p.m.
Last Modified: Friday, January 19, 2007 at 9:22 p.m.
Joe, Annette, Rene', Erin and John at the Saints game in Dallas...
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.
Comments are currently unavailable on this article


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FiltersShow / Hide
- All Events
- Music
- Comedy
- Theatre & Shows
- Sport
- Cinema
- Festivals
- Days Out
- Edinburgh Fringe
- Anywhere In The UK
- Location: Anywhere in the UK
Radius: ... miles
This event has been and gone!
Catch the next one:
Check out the info below for future tour dates, and track them to receive alerts when they tour near you
Never miss another 'Yes' show
Grammy award-winning rock luminaries, Yes, have announced a triple-album Europe 2014 tour, performing three of rock's most influential albums, 'The Yes Album', 'Close to the Edge', and 'Going for the One', in their entirety.
This event takes place at Royal Albert Hall, which has achieved Silver Status for disabled access from Attitude Is Everything.
One of the defining classic rock bands of the '70s combining complex compositions with outrageously intricate instrumentation.
Yes tour dates
Track this event
- Event has been added to your calendar
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Venue Facts
Venue: Royal Albert Hall
Disabled Access: Silver Status
Website: royalalberthall.com
Enquiries: 020 7589 8212
Bookings: 0845 401 5034
Disabled Bookings: 020 7838 3110
Seating Plan: View the Seating Plan
→ South Kensington 10 min walk
→ Gloucester Rd 11 min walk
→ Knightsbridge 13 min walk


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New Braunfels, TX Liquor, Wine, And Beer
NB Liquor & Wine
Are you just visiting or just moved to the area and can't seem to find a liquor, wine, and beer store anywhere? Your search is over when you visit NB Liquor & Wine in New Braunfels, TX. You can choose from one of the largest selections in the area, and each week we feature a new liquor, wine, or beer.
Know more about us:
- Wine
- Beer
- Liquor
We are close to Schlitterbahn, Gruene, and Rivers.
Contact NB Liquor & Wine today at 830-626-1308.
Contact Information
Hours of Business:
Monday – Saturday: 10:00 am – 9:00 pm
Sundays: Closed
Monday – Saturday: 10:00 am – 9:00 pm
Sundays: Closed
Methods of Payment:


text:
If the 2012 presidential campaign seems to smell worse than other election campaigns, it's because it does.
The majority of that stench is coming from the national Democratic headquarters where it has been decided the best way to keep attention away from President Barack Obama's four inept years in office is to try and defame Republican challenger Mitt Romney.
In 2008, Obama famously ran as the candidate of "hope and change." During the past four years, we've seen what that means. And just when it seemed Obama and his minions couldn't stoop get any lower, Priorities USA - a Democratic super PAC formed by former White House spokesman Bill Burton - has dredged to previously unknown depths of sleezy politics. The ad - which has even been condemned by many Democrats - blames Romney for the cancer death of a woman whose husband lost his health insurance benefits after he was laid off from his job at a steel plant after being purchased by Bain Capital.
However, in reality, the unfortunate woman died six years after her husband's plant closed and during that time she had her own health benefits until she, too, lost her job.
While the Obama campaign tried to distance itself from the ad, they also used Joe Soptic, the steelworker in question, in a campaign appearance six months ago where he made the same charge while Obama stood to the side nodding in agreement with everything the man said.
It is easy to understand why Democrats would attempt to keep attention away from Obama's sorry record during the last four years. While the economy was certainly reeling when the president took office in 2008, his policies have only lead us closer to the cliff today.
In the meantime, when Obama does address the bad economy, he continues to blame former President George W. Bush's policies, or the situation in Europe or some other economic boogyman for its condition.
Anybody but himself and his own failed policies.


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Upcoming Fishing Tournaments
Published: Wednesday, January 9, 2013 at 11:53 p.m.
Last Modified: Wednesday, January 9, 2013 at 11:53 p.m.
THE FISHING MISFITS will hold an open tournament Saturday on the north Winter Haven chain out of Lake Rochelle. No pros or guides. For boats with 100-HP outboards and under. Call Harry at 863-660-2054 or Larry at 863-287-2864, or check http://mysite.verizon.net/resqxc7y/.
THE POLK COUNTY BASS AND SNOOK CLUB will compete on the south Winter Haven chain Saturday. The club is accepting new boater members for the 2013 season. Visit www.polkcountybassandsnookclub.com or call Mike Howell at 863-646-2481.
THE WEST COAST COUPLES Bass Club will open the season Saturday on East Lake Toho out of East Lake Fish Camp. Entry fee $55, including big bass. Membership $20 per couple. 100 percent payback. Club meets in Tampa on Wednesdays before the second Saturday of the month. Call Fred Allen at 863-676-3764 or Chrissy Crocker at 813-927-0738.
THE PERFORMANCE BASS ANGLERS will hold their kickoff classic Saturday on the south Winter Haven chain. Visit www.performancebassanglers.com.
THE WATER'S EDGE BAIT AND TACKLE Bass Tournament trail begins Saturday. Tournaments will be on Lake Rosalie out of Water's Edge Fish Camp the second Saturday every month. Entry fee $50 plus $10 for big bass. 100 percent payback. Boat ramp fee $5. One or two-man events. Pre-register at tackle shop or call Dave or Joyce at 863-455-6960.
THE LAKELAND JUNIOR BASSMASTERS will compete Saturday on Lake Parker. For information on tournaments or membership, call Martin Bozeman at 863-640-8349 or check www.lakelandjuniorbassmasters.com.
THE LAKELAND BASSMASTERS open the season Sunday on the south Winter Haven chain out of the old Lake Shipp ramp. Nick Nicknadarvich is the club's new president. Club meets the second and fourth Tuesday each month at the Lakeland Elks Lodge at 7 p.m. New members are welcome. Check www.lakelandbassmasters.org.
THERE WILL BE AN OPEN BIG BASS TOURNAMENT on the south Winter Haven chain out of the new ramp on Lake Shipp Sunday. One fish per boat limit. Safe light to 11 a.m. Entry fee $15 per person. No guides on lakes they guide on. Call Mark at 863-860-8287.
THE ABA COUPLES FLORIDA DIVISION will compete on West Lake Toho out of Lakefront Park Jan. 19. Other tournaments: Feb. 16, Lake Panasoffkee out of Tracy's Point; March 17, Harris Chain out of Buzzard Beach; April 21, Johns Lake; May 18, Lake Istokpoga out of Henderson's. Call Cary Wien at 305-522-1919 or check www.ABAcouplesFlorida.com.
THE BHS YELLOW JACKETS BASS FISHING TEAM at Bartow High School will compete on the Kissimmee Chain in the Kissimmee Klash Jan. 19 out of Port Hatchineha. Contact tournament director Derek Boswell at 863-513-8877 or e-mail email@example.com.
THE LAKELAND JUNIOR HAWG HUNTERS will compete on the south Winter Haven chain out of Lake Summit Jan. 19. Call Cheryl Brewer at 863-224-0045 for information on tournaments or membership.
THE SUNDAY OPEN SERIES TOURNAMENT trail will be in action Jan. 20 on the south Winter Haven chain out of Lake Shipp Park. Tournaments will be every other week. Entry fee $30, including big bass. 100 percent payback. Safe light to 1 p.m. Fishermen can qualify for the 11th event, the mini-classic, by competing in at least seven events. Call Willard Combee at 863-670-7647.
THE XTREME BASS KISSIMMEE DIVISION will kick off the season Jan. 20 out of Camp Mack. Entry fee $120 per team, including big bass. One-time membership fee $35 per angler. Safe light to 3 p.m. Tony Bartels is the division director. Upcoming tournaments: Feb. 2, March 10, April 14, May 26, June 9, July 14, Aug. 11, Sept. 8, championship Oct. 25-27 on Lake Seminole. Championship winner receives 119 Ranger. Check www.xbseries.com.
THE CASTAWAYS BASS CLUB will open the 2013 season Jan. 26 on the north Winter Haven chain out of Lake Rochelle. Call Johnny Lockaby at 813-833-5786 or check www.castawaysbassfishing.com.
THE OUTCASTS BASS CLUB Team Trail will open the season Jan. 26 on Lake Arbuckle. Entry fee $60 per boat, including big bass. Membership $35 per angler. 100 percent payback. Upcoming tournaments: Feb. 23, Lake Istokpoga; March 23-24, Lake Okeechobee; April 27, Kissimmee Chain; May 18, Lake Walk-in-the-Water; June 22, West Lake Toho; July 27, Lake Panasoffkee; Sept. 28, Kissimmee Chain; Nov. 2-3, classic. Check www.OutcastsBassClub.net or call 813-973-4509.
THE FLORIDA CRAPPIE CLUB South and Western Divisions will start the 2013 season Jan. 26 on Lake Tarpon out of Anderson Park. The North Division opens on the Harris Chain out of Buzzard Beach Jan. 12. Entry fee $50 plus $10 for biggest speck. Individuals or partners. Seven-fish limit. 7 a.m. to 2:30 p.m. No membership fee. Upcoming tournaments for the South and Western divisions: Feb. 23, Lake Manatee out of state park; March 23, Lake Istokpoga out of public ramp on 621; April 27, Lake Okeechobee out of Okeetantie; May 25, Lake Kissimmee out of Camp Mack; June 22, Crooked Lake out of Bob's Landing; July 27, Lake Walk-in-the-Water out of county ramp; Sept. 28, Lake Arbuckle; Oct. 26, Lake Manatee; Nov. 23, Lake Tarpon; Dec. 14, classic, Crescent Lake. No North Division tournaments on Polk lakes. Call Harold McGhee at 813-215-9759 for the South Division. Call Darryl Cole at 352-516-0869 for the North Division.
THE CAMP MACK TEAM TOURNAMENT TRAIL will kick off the season Jan. 27 on the Kissimmee Chain out of Camp Mack. All tournaments out of Camp Mack on Sundays. Entry fee $65 per boat, plus $10 for big bass. 80 percent payback each tournament, with 20 percent held for classic. Must fish seven events to qualify for classic. Safe light to 2 p.m. Upcoming tournaments: Feb. 24, March 24, April 28, May 19, June 30, July 28, Aug. 25, Sept. 29. Classic Oct. 12-13. Call 863-696-1108.
THE LAKE WALES PO' BOYS Bass Club will compete on Lake Toho (only) Jan. 27 out of Southport Park. Safe light to 2 p.m. Check www.lakewalespoboys.com for information, or call 863-781-0736 or 863-632-1643.
THE CAMP MACK OPEN ONE-MAN TOURNAMENT TRAIL on the Kissimmee Chain out of Camp Mack will compete Feb. 3. Tournaments the first Sunday of the month through October, with the classic Nov. 2-3. Entry fee $85 plus $10 for big bass. Safe light to 2 p.m. 80 percent payback each tournament, with 20 percent held for classic. Call Camp Mack at 863-696-1108.
THE TAMPA PRO BASS trail will compete Feb. 3 on Lake Istokpoga out of the U.S. 98 ramp. Upcoming tournaments: March 3, Harris Chain out of Hickory Point; April 7, Kissimmee Chain out of Camp Lester; May 5, West Lake Toho only out of Southport Park; June 1-2, classic on Lake Istokpoga out of U.S. 98 ramp. Entry fee $70 per boat, including big bass. Membership ($25 per angler) required. Safe light to 2:15 p.m. No trolling or dragging is allowed. Call John or Wendy Taylor at 727-403-6861 or 727-789-0525, or check http://home.roadrunner.com/~tampapro.
THE FISHING FOR A CURE Bass Tournament is Feb. 9 on the south Winter Haven chain out of Lake Shipp Park. Entry fee $100 per boat plus $5 per person for big bass. Benefit for the American Lung Association presented by Nurse on Call Home Health Care. First place pays $2,000, with $750 for second and $250 for third. Safe light to 1 p.m. Raffle after weigh-in with tickets $2 each or six for $10. Pre-register at Ron's Tackle Box in Lake Alfred or call Ron's at 863-956-4990.
THE WINTER HAVEN LUNKER LOVERS will compete Feb. 10 on Lake Toho only out of Southport Park. Upcoming tournaments: March 2-3, Lake Okeechobee out of Okeetantie; April 14, Kissimmee Chain out of Camp Lester; May 19, Lake Istokpoga out of Istokpoga Park; June 8-9, Harris Chain out of Buzzard Beach; July 7, Kissimmee Chain out of Camp Lester; Aug. 11, Lake Walk-in-the-Water out of county ramp; Sept. 8, Kissimmee Chain out of Camp Lester; Oct. 5-6, Lake Istokpoga out of Trail's End; Nov. 9-10, Classic on Kissimmee Chain out of Camp Lester. Call Jim Rose at 863-514-6582 or check online at http://lunkerlovers.com.
THE LAKELAND HAWG HUNTERS will fish on Lake Toho Feb. 10 out of Southport Park. Call Doug Gary at 863-559-0094.
[ Send tournament notices or results to Del Milligan, P.O. Box 408, Lakeland, Fla., 33802, or fax to 802-7812. Deadline is Wednesday noon. Include date, entry fee and phone. ]
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Blackhawks 4, Ducks 2
Chicago's win snapped Anaheim's eight-game winning streak and was only the second loss in the last 20 games for the Ducks (36-9-5).
It was goaltender Jonas Hiller's first loss after a team record 14 straight wins, the second-most in NHL history.
Chicago (31-8-11) had lost four of their previous five games.
- - -
Blue Jackets 5, Capitals 1
Outside of the first-place Pittsburgh Penguins, the NHL's Metropolitan Division looks like a 5 p.m. traffic jam. The Columbus Blue Jackets and Washington Capitals are currently headed in different directions.
Four different players scored goals, two of them on power plays, and the Blue Jackets continued their midseason turnaround, routing the Capitals 5-1.
The Blue Jackets have won a season-long five straight games while the Capitals have lost 11 of their last 15.
The win kept Columbus in sixth place in the Metropolitan, but only four points separate seventh-place Carolina (49) and second-place Philadelphia (53).
Cam Atkinson scored two goals, with James Wisniewski, Ryan Johansen and Mark Letestu also scoring.
- Sports & Recreation
- Ice Hockey
- Washington Capitals
- Ducks
- Columbus Blue Jackets
- Jonas Hiller


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How to Make Suave-tastic Sock Garters
Don't let sartorial dejection impede success! Sock garters are for everyone, not just kilt-wearers! Haley of wildwoodflwrv posted this easy-peasy tutorial on how to make sock suspenders. Make them in several colors and coordinate with your suit trousers! Sock garters add a hidden suave finishing touch to any attire.


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When accessing the Internet from a laptop or other mobile device, you will be presented with a login page (shown in the screen-shot below). You will need to enter your UH username and password.
The wireless network at UHKCC is equipped with the "wireless pass-through" feature. This feature allows users to register the network hardware address (MAC address) for their laptop, phone, or other mobile device. Thus eliminating the need to log in all the time. Pass-through registration is valid for one year, and may be renewed as necessary.
The URL to register for wireless pass-through is http://www.hawaii.edu/wireless/pt
In order to register for wireless pass-through, you must have your MAC address. Instructions for finding it can be found at http://www.hawaii.edu/askus/1035
Please direct any questions to our helpdesk at 734-9711.
Setting up Guest Accounts for WiFi
The following procedures for inviting Guests to our campus WiFi are available to Faculty and Staff only.


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Training to Be Held For Reading Tutors
Published: Friday, April 12, 2013 at 5:03 a.m.
Last Modified: Friday, April 12, 2013 at 5:03 a.m.
A free workshop will be held April 20 to train volunteers who would like to teach adults to read.
READ Polk will hold the workshop, hosted by the Lake Wales Literacy Council, from 8:30 a.m. to 3:30 p.m. at Polk State College's J.D. Alexander Center at 152 E. Central Ave. in Lake Wales. Breakfast and lunch will be provided.
Volunteers will obtain the training and material necessary to become certified tutors. Class size is limited. To register, call 863-676-5767 or email email@example.com by noon April 17.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Light towers being installed at Morshead Park, soccer, major projects
Four light towers are being installed on both the main show pitch and second synthetic pitch at the Ballarat Regional Soccer Facility.
Crews were busy installing towers on the synthetic pitch this morning as part of the latest stage of works at the facility.
Morshead Park will have three fully lit soccer pitches when the latest stage of works is complete.


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Definition of catsuit in English:
A woman's jumpsuit, typically close-fitting and covering the body from the neck to the feet.
Example sentences
- Pencil skirts, pedal pushers (with black vinyl bottoms on a mock croc print), catsuits and zipped jackets combine to form a strong urban theme.
- Expect all the hits from the film as the cast transport you back to the days of leather jackets, skin tight catsuits, hipsters and squares.
- She grinned as she laid out her new outfit; it was a latex catsuit, complete with built-in socks for her feet, and gloves for her hands.
For editors and proofreaders
Syllabification: cat·suit
Definition of catsuit in:
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
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PMA Special Considerations
Please note: As of October 1, 2002, FDA charges a fee for review of Premarket Approvals
- Biocompatibility
- Color Additives
- Combination Products
- Electromagnetic Compatibility
- Electronic Submissions
- Environmental Impact Considerations
- Expedited Review
- Expiration Dating
- In Vitro Diagnostic (IVD) Products
- Master Files
- Radiation Emitting Products
- Software
- Standards
- Sterility
Biological evaluation of medical devices is performed to determine the potential toxicity resulting from contact of the component materials of the device with the body. The device materials should not, either directly or through the release of their material constituents: (i) produce adverse local or systemic effects; (ii) be carcinogenic; or, (iii) produce adverse reproductive and developmental effects. Therefore, evaluation of any new device intended for human use requires data from systematic testing to ensure that the benefits provided by the final product will exceed any potential risks produced by device materials.
FDA recognizes the standard ISO 10993 (International Standards Organization) for biological evaluation of medical devices. This standard provides guidance for selecting the tests to evaluate the biological response to medical devices. When selecting the appropriate tests for biological evaluation of a medical device, the chemical characteristics of device materials and the nature, degree, frequency and duration of its exposure to the body must be considered.
The specific clinical application and the materials used in the manufacture of the new device determines which tests are appropriate. Some devices are made of materials that have been well characterized chemically and physically in the published literature and have a long history of safe use. Therefore, it may not be necessary to conduct all the tests suggested in the FDA's testing guidance matrix.
Additional information on biocompatibility can be found in the following guidance document:
Required Biocompatibility Training and Toxicology Profiles for Evaluation of Medical Devices, Blue Book Memo, G95-1
Color Additives
Color additives in medical devices are subject to the same provisions that apply to color additives in foods, drugs, and cosmetics. A color additive is a dye, pigment, or other substance, whether synthetic or derived from a vegetable, animal, mineral, or other source, which imparts a color when added or applied to a food, drug, cosmetic, or the human body. The Food, Drug and Cosmetic (FD&C) Act states that devices containing a color additive are considered unsafe, and thereby adulterated, unless a regulation is in effect listing the color additive for such use. The FD&C Act limits applicability of these provisions to color additives for devices that directly contact the body for a significant period of time. At the present time, the term a "significant period of time" is not defined by FDA regulation.
The color listing regulation may permit use of the color additive in a generic type of device, such as contact lenses, or may place limitations on its use, such as polypropylene nonabsorbable sutures for general surgical use but not for ophthalmic surgical use.
PMA applicants must demonstrate color additives remaining in and on the device are safe. Manufacturers may choose an appropriate color additive approved for medical devices in accordance with its use and restrictions. Color additives listed for use in medical devices are provided in 21 CFR 73 and 21 CFR 74.
- Part 73, Subpart D: Color additives exempt from batch certification
- Part 74, Subpart D: Color additives subject to batch certification
If a color additive has not been previously listed, the manufacturer must submit a color additive petition to FDA. If the PMA is submitted before the color additive petition is approved, the PMA approval will be delayed.
In searching for an appropriate color additive for use in its device, manufacturers should consider color additives listed for use in foods, drugs, or cosmetics as a starting point. However, the safety data of the color additive for a food, drug, or cosmetic may not be relevant to devices. That is, the color additive may be used in a different part of the body or for a longer duration than that approved.
The following provides additional guidance on color additives.
Color Additives For Medical Devices
Color Additives - Center for Food Safey and Applied Nutrition
Combination Products
A combination product is a product comprised of two or more regulated components (drug/device or biologic/device) that are combined as a single entity or is a product labeled for use with a specified drug, device, or biologic where both are required to achieve the intended use, indication, or effect.
To ease the regulatory burden of industry, FDA has established Intercenter agreements which establishes the lead FDA Center for review and oversight of certain categories of products. Intercenter agreements with CDRH are referenced below.
Intercenter Agreement Between the Center for Biologics Evaluation and Research and the Center for Devices and Radiological Health.
Intercenter Agreement Between the Center for Drug Evaluation and Research and the Center for Devices and Radiological Health.
Some combination products involve cutting edge, novel technologies that raise not only unique scientific and technical questions, but also regulatory challenges related to where and how they should be regulated in order to ensure adequate and consistent regulatory oversight. The Office of Combination Products assigns review responsibility for combination products. The Office is also responsible for designating the component of FDA with primary jurisdiction for the premarket review and regulation of any product requiring a jurisdictional designation.
Additional information regarding combination products can be found at the following website:
Office of Combination Products
Electromagnetic Compatibility
PMA applicants must demonstrate that the device is electrically safe and does not interfere with other devices used in the same environment. Electromagnetic compatibility, or EMC, means that the device is compatible with (i.e., no interference caused by) its electromagnetic environment, and that it does not emit levels of electromagnetic energy that cause electromagnetic interference (EMI) in other devices in the vicinity. The wide variation of medical devices and use environments makes them vulnerable to different forms of electromagnetic energy which can cause electromagnetic interference. Additional guidance and information CDRH activities in this area is available on the "CDRH Medical Device Electromagnetic Compatibility Program" website.
Electronic Submissions
CDRH accepts medical device applications in electronic form. PMA applicants should notify the reviewing division of CDRH of their desire to submit an application in electronic form prior to submission. This lead time is needed to discuss any special considerations with the submitter prior to development of the documents.
The application should be submitted in a PDF (Portable Document Format) format as the PMA review staff will use Acrobat Exchange to review the submission. This will assure that what a reviewer sees on the screen is the same as what would have been seen on paper. Applications may be submitted on floppy diskettes or CD-ROM. At least one paper copy of the submission is also required.
An electronic application does not change the order in which submissions are reviewed. No preferential treatment will be given to manufacturers who submit an electronic application. Additional copies of some reports may be requested in order to help facilitate the review.
Additional information on electronic copies can be found the Internet.
Environmental Impact Considerations
21 CFR 814.20(b)(11) states that an environmental assessment in accordance with 21 CFR 25 must be included in the PMA application. However, PMA applications do not ordinarily require an environmental assessment (EA) or environmental impact statement (EIS). Devices of the same type and for the same use as a previously approved device are categorically excluded from an EA or an EIS [§25.34(d)]. These devices compete for the same market with already approved devices of the same type and use, and therefore, there is no increased environmental impact resulting from the introduction of the device into commercial distribution. A statement requesting a categorical exclusion under sections 25.15 and 25.34(d) is required in the PMA application.
If the device causes environmental hazards in the manufacture, use, or disposal of the device, an environmental assessment must be submitted in the PMA.
Expedited Review
Expedited review of devices subject to PMA will generally be considered when a device offers a potential for clinically meaningful benefit as compared to the existing alternatives (preventative, diagnostic, or therapeutic) or when the new medical device promises to provide a revolutionary advance (not incremental advantage) over currently available alternative modalities.
FDA considers a device appropriate for expedited review if the device:
- is intended to treat or diagnose a life-threatening or irreversibly debilitating disease or condition, and
- addresses an unmet medical need, as demonstrated by one of the following:
- The device represents a breakthrough technology that provides a clinically meaningful advantage over existing technology; or
- No approved alternative treatment or means of diagnosis exists; or
- The device offers significant, clinically meaningful advantages over existing approved alternative treatments; or
- The availability of the device is in the best interest of patients.
Granting expedited review status means that a marketing application that is determined to be appropriate for expedited review is placed at the beginning of the appropriate review queue and receives additional review resources, as needed.
Additional information on the criteria and procedure for expedited review are provided in the following guidance document:
Expedited Review of Premarket Submissions for Devices
Expiration Dating
Under 21 CFR 809, In Vitro Diagnostic Products for Human Use, the labeling must provide an expiration date based upon the stated storage instuctions. Other devices are not required to have expiration dating, but may be appropriate. If expiration dating is provided in the labeling, it must be based upon the storage instructions provided in the labeling and substantiated through stability testing. Data to support the expiration date must be provided in the PMA and maintained as part of Quality System records under 21 CFR 820. Guidance on shelf life protocols can be found in the following guidance documents.
21 CFR 211.166 Stability testing
Guidance for Industry: Q1A Stability Testing of New Drug Substances and Products
Evaluation of Stability Data
Guideline for Submitting Documentation for the Stability for Human Drugs and Biologics
Stability Testing of Drug Substances and Drug Products
Q5C Quality of Biotechnological Products: Stability Testing of Biotechnological/Biological Products
In Vitro Diagnostic (IVD) Products
In vitro diagnostics are medical devices that analyze human body fluids, such as blood or urine, to provide information for the diagnosis, prevention, or treatment of a disease. The device classification for these devices can be found under 21 CFR 862, 21 CFR 864, and 21 CFR 866.
In Vitro Diagnostic Products have special labeling requirements and distribution restrictions under 21 CFR 809, In Vitro Diagnostic Products for Human Use. Additional guidance can be found under "Device Advice Labeling Requirements for In Vitro Diagnostic Devices."
Clinical Laboratory Improvement Amendments (CLIA) of 1988
In addition to FDA regulation under the Food, Drug, and Cosmetic Act, in vitro diagnostic (IVD) devices are also subject to the Clinical Laboratory Improvement Amendments (CLIA) of 1988. This law established quality standards for laboratory testing and an accreditation program for clinical laboratories.
The requirements that apply vary according to the technical complexity in the testing process and risk of harm in reporting erroneous results. The regulations established three categories of testing on the basis of the complexity of the testing methodology: waived tests, tests of moderate complexity, and tests of high complexity. Laboratories performing moderate- or high-complexity testing or both must meet requirements for proficiency testing, patient test management, quality control, quality assurance, and personnel. These specific requirements do not apply to tests in the waived category.
In January 2000 the categorization of commercially marketed in vitro diagnostic tests under CLIA was tranferred from the Center for Disease Control and Prevention (CDC) to FDA. CDRH's Office of of In Vitro Diagnostic Device Evaluation and Safety (OIVD) determines the appropriate complexity categories for clinical laboratory devices as they evaluate premarket submissions. Waived products, devices exempt from premarket notification, and devices under premarket review by other FDA Centers are also processed by OIVD. Responsibilities currently assigned to CDC, including review of test systems, assays, or examinations not commercially marketed as IVD products, will remain with CDC.
Below is a list of CLIA Program Information Resources:
FDA CLIA Website (complexity categorizations, waiver)
CMS CLIA Website (program information, statistics, etc.)
CDC CLIA Website (regulations, CLIAC)
Additional information on assignment of CLIA categories by FDA can be found on the Internet.
Additional IVD Guidance
For additional information on in vitro diagnostics devices, please visit the Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD) website.
Master Files
A PMA applicant often utilizes another party's product (e.g., material, ingredient, subassembly, or accessory) or facility in the manufacture of the device. Although information regarding the third party's product is pertinent to the review of the PMA, the third party may not want to divulge confidential or trade secret information to the PMA applicant. To preserve the trade secrets of the ancillary medical device industry and at the same time facilitate the sound scientific evaluation of medical devices, FDA allows the third party to submit the confidential information directly to FDA in a device master file. A master file may also be considered when several applications may be submitted for different products which may use a common material or process. However, different uses of the medical device may require additional testing or information to support the evaluation of that particular product.
Please note that a master file is NOT a marketing application. It is not independently reviewed or approved. A master file is only reviewed when a premarket submission [PMA or Premarket Notification 510(k)] under review contains an authorization letter from the third party that permits FDA to review the master file to support the premarket submission. Since the master file may contain additional information than required for the review of the submission, the authorization letter should specify the appropriate sections or pages for review.
Additional guidance on master files can be found in the following guidance document.
Radiation Emitting Products
If your medical device also emits electronic product radiation, additional requirements apply under the Electronic Product Radiation Control Provisions of the Food, Drug and Cosmetic Act. Electronic product radiation means:
- any ionizing or non-ionizing electromagnetic or particulate radiation,
- or any sonic, infrasonic, or ultrasonic wave,
- which is emitted from an electronic product as the result of the operation of an electronic circuit in such product.
Examples of products that emit electronic radiation include lasers, ultraviolet lamps, microwave ovens, ultrasound therapy devices and medical diagnostic x-ray equipment.
Regulatory requirements for these products are in place to protect the public from hazardous or unnecessary radiation exposure emitted by these products. Requirements may include submission of reports to FDA, compliance with applicable radiation safety performance standards, retention of certain records, and reporting of accidental radiation occurrences or product defects to FDA. Additional information on requirements for radiation emitting products is available on the Radiological Health Program website.
If the device contains software or is controlled by a computer, the submission should contain documentation of software development and validation appropriate to the level of risk of the software. The submission should include any information, prompts, and cautions displayed by the system. The software documentation should support all performance and safety claims.
The following guidance documents provide guidance on the recommended software documentation for a premarket submission and on software validation.
- Guidance for the Content of Premarket Submissions for Software Contained in Medical Devices
- Guidance for Off-the-Shelf Software Use in Medical Devices
- Cybersecurity for Networked Medical Devices Containing Off-the-Shelf (OTS) Software
- General Principles of Software Validation
Conformance with recognized consensus standards can provide a reasonable assurance of safety and/or effectiveness for many aspects of medical devices. Information submitted on conformance with such standards will have a direct bearing on safety and effectiveness determinations made during the review of premarket submissions. If any premarket submission contains a declaration of conformity to the recognized consensus standards, this will, in most cases, eliminate the need to review the actual test data for those aspects of the device addressed by the standards.
Conformance with recognized consensus standards in and of itself, however, may not always be a sufficient basis for regulatory decisions. For example, a specific device may raise a safety or effectiveness issue not addressed by any recognized consensus standard, or a specific FDA regulation may require additional information beyond what conformity to the recognized consensus standards provides. Under such circumstances, conformity with recognized standards will not satisfy all requirements for marketing the product in the United States.
FDA recognizes certain consensus standards. If the device complies to an FDA recognized standard, the applicant may need only submit a declaration of conformity to the standard without submitting test data. Conformance to FDA recognized standards are voluntary and may be used to demonstrate performance or safety of a device.
Information on FDA's standard program including a database of FDA recognized standards can be found on the following website:
The sterilization method (e.g., steam heat, ethylene oxide, radiation), sterility assurance level (SAL), description of the packaging to maintain the device's sterility, and method of validation must be provided in the PMA. The manufacturer may use an FDA recognized validation method or an equivalent method. Additional information on sterilization can be found here:
- FDA Guidance on Sterility: Submission and Review of Sterility Information in Premarket Notification (510(k)) Submissions for Devices Labeled as Sterile Guidance for Industry and Food and Drug Administration Staff
- Although this guidance document refers to 510(k) Submissions, the information may also be used for PMA submissions.
- CDRH Standards Database
- For a list of sterility-related standards, go to the field "Specialty Task Group Area" and select "Sterility"


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Wild Atlantic Way
»This year, journey through the Wild Atlantic Way to immerse yourself in the stunning landscape of Ireland.
Great holiday ideas
»Discover a wealth of amazing holiday ideas and activites with our list of things to do. Take your family, friends or someone you love on some great adventures.
Self catering
»Stay in a cosy Irish home away from home and venture out to explore our beautiful scenery.
Search all festivals
»Experience a host of festivals and events taking place around the country this year.
»Start your search for the perfect Irish break now. What's stopping you?
One of Ireland's warmest and brightest months, August is the perfect time of year for a festival. Nationwide, a host of fairs and fêtes are taking place.
Hail the king of the goats at Kerry's one and only Puck Fair, or sample regional delicacies at the Waterford Harvest Festival. The Tiger Dublin Fringe turns the capital city on its head for 16 days of cutting-edge spectacle, while on the opposite coast, Fleadh Cheoil na hÉireann gathers the very best of traditional music talent in Clare for the biggest annual Irish music event.
You can celebrate 57 years of the ever-charming Rose of Tralee, or if you're feeling truly adventurous, why not discover which fish in the sea are right for you at the Lisdoonvarna Matchmaking Festival?
The Wild Atlantic Way App is your trusted guide along the Atlantic Coast of Ireland. This free app is available to download for iOS and Android.
Dublin offers so much more than a city break—find some inspiring ideas to make your break in Dublin a breath of fresh air and exhilarating fun.
Discover a wealth of amazing holiday ideas and activites with our list of things to do. Take your family, friends or someone you love on some great adventures.


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Division of Student Affairs
Students Plan for Success
Conference Helps Students Plan for Success
On October 16, 2012, Student Support Services (SSS), a federally-funded TRIO program providing academic and other support services for low-income, first-generation students, teamed up with professionals from Academic Affairs for this semester's Success Conference. More than 125 students packed the Multipurpose Room to learn how to secure and manage the funds necessary for them to continue their coursework and graduate from BGSU. Holly Cipriani, Outreach Coordinator and Counselor with Student Financial Aid, focused on how students can maintain their academic eligibility for grants and loans; Patricia Donnelly, Program Manager with Student Money Management, presented strategies on budgeting; and Sidney Childs, Executive Director of the TRiO programs, explained a special grant aid opportunity that SSS has secured for students.
SSS staff members understand that, in the words of Hillary Clinton, "talent is universal, but opportunity isn't." They view the achievement of academic goals as a critical step towards future success for the first-generation, low-income students with whom they work. One SSS student at the conference noted how receiving the grant aid will help relieve the financial stress on her mother, who has one child at home and two in college. She stated the funds will ensure that she continues advancing towards her social work degree, a path on which she has embarked to give back to her community and work with children in need.


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This company is doomed
Sentiment: Strong Sell
Pls. do me a favor.
Rboy from the EBIX board lol. You have not proven yourself to be very smart. LULU is not doomed, it is merely overvalued. I'd buy at 54......stay away till then.
I was shorting LULU when it was over 70. Will cover at 55. That was my trade. And its not looking good for them. I dont think you were around when Crocs and UA fell 50% plus in 2 qtrs.
LOL, bailing out, christine the biaaaaaatch knew about this
check yahoo finance insider trades DUMBAAAAAAAAAAAAAAAAAAAAAAAAAAAAS
Please provide link...this could be huge hit!!!


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Aug 8, 2009
Auschwitz Photos
Human hair removed from the heads of murdered women prisoners. When the Red Army liberated the camp, 7000 kilos were found awaiting shipment to the Third Reich.
The hair had been sent back to Germany, then converted into hair cloth.
SS duty officer's room in the death block.
This room also served as a court room for the
Summary Police Court in Block no 11.
Wall of execution; here about 20.000 prisoners were executed – mainly Polish political prisoners. The Extra Ordinary Court came from Krakow and during a session of 2-3 hours, imposed sentences upon a handful to several hundred prisoners. The court's judgement in most cases: summary execution.
The Execution Wall stands between blocks nos. 10 & 11. Block no. 10 to the left and Block no. 11 to the right, stand out from the rest because of the incredible cruelty that went on behind these brick walls.
This multiple gallows is also located on the Roll-Call Square. Before prisoners were placed in the gallows, they had their arms twisted behind their backs, and then, by their arms, were placed in the gallows as a public warning to anyone trying to escape the Camp. The penal roll call was used as collective punishment for a violation by any one prisoner.
Booth belonging to the Rapport Führer. On the Roll-Call Square in front of this booth, public executions were held, at times accompanied by orchestral music.
The Roll Call Square seen from a distance. During these rollcalls, the entire camp stood silently as the SS called out each prisoner's name, seeing that all the prisoners were accounted for.
One of the main fences.
6000 volts ran through the wires of this fence.
Multiple fences.
One of many warning posts
found alongside the barbed wire fencing.
Insulators and barbed wire on a post.
Crematorium, mortuary used as a gas chamber.
It was originally used as storage room for ammunition.
September 3, 1941 experimental gassing on
Soviet prisoners using Zuclon-B.
Two out of the three chambers in the crematorium at Auschwitz I. When in operation, the crematorium had a capacity for incinerating 350 bodies per day. In each chamber 2-3 bodies were placed. In 1941 and 1942 Soviet prisoners of war and Jews from the ghettos established by the Nazis in Schlesien were murdered in this crematorium.
The crematorium was in use from 1940 – 1943. The ashes were used as fertilizer or as filling in nearby creeks and ponds. The last gassings took place in November 1944. Just prior to the liberation of the camp the SS dismantled and blew up the crematoriums. The ruins can be seen today.


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A North Carolina woman was charged with embezzling more than $100,000 from the church where she used to work.
Gloria Douglas Hardee faces charges in connection with alleged embezzlement from Riley's Creek Baptist Church in Pender County, WECT reported.
Hardee used to the secretary and treasurer of the church. She was arrested following audits by the church as well as the Baptist Association of Wilmington, Pender County deputies said.
Church officials said they were first notified of possible problems with church financial statements last July.
Hardee's first court appearance was scheduled for March 12.


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Thursday, March 20, 2014
Augusta, Ga. (WRDW) -- In the words of the spokesman for Cabela's Outdoor Store, "Augusta lives the Cabela's lifestyle."
That phrase can now be deemed correct as Cabela's officially opens their doors to the public in the CSRA.
"It's a new adventure for us and the southeast is a territory we haven't explored yet," said Wes Remmer, with Cabela's.
He's certainly right. This store marks the outdoor chains 51st store in the nation. It's the first in Georgia and the southeast.
After Cabela's announced it's venture to the area, construction began immediately off Riverwatch Parkway, an ideal location for the outdoor store putting it hundreds of feet from the Augusta Canal.
Remmer says Augusta was a perfect location to begin the journey to the southeast.
The store contains everything from guns to kayaks, fishing gear to camping equipment, clothing to meat slicers.
You would also be able to get your fishing license at the store.
More than a day before Cabela's opened, a line outside was already forming.
Tracy Lingle secured his spot in line a little after four on Wednesday morning, the first person in line.
"We wanted to get out a little earlier, maybe even on Tuesday, because we really wanted to be the first in line," he said,
His reasons include free prizes from Cabela's ranging anywhere from hundreds of dollars in gift cards to a grand prize of $1,000 bucks.
Inside, store employees still working hard to make last-minute changes to a store fully-stocked with outdoor gear.
It's a day all employees and people in Augusta have been looking forward to, and now it's finally here.
The ribbon cutting ceremony will take place at 10:45. Shortly after, doors will open at 11 a.m.


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Kids and their families got a rare opportunity to tour the Bengals stadium and collect candy at the second annual Bengals Kids Club Halloween event.
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2month old baby girl has a patch of hair in her butt crack about 1/2 in above her rectum. Why?
This question has not been answered by one of our experts yet.
Hi, My daughter had the same thing and with a dimple and all the docs said it was fine and don't worry about it. Well I worried about it and found a doctor who did a MRI and found that she had a tethered spinal cord.
She had back surgery at 9 months and is doing well today. A tethered spinal cord can lead to problems.
Have it checked out!READ MORE
Hi- I saw your post on health central about your daughter's tethered spinal cord. What kind of doctor did you see that found the issue. My 6 month old girl has a long butt crack- can't think of a more descriptive way to explain it. She had and ultrasound when she was one day old, and they said no worries, nothing internal was affected. The pediatrician joked that the official diagnosis was "a dimple on her butt" and I'd never have to worry about her wearing low-rider jeans.
Still... I'm worried. I've noticed that it's hairy in there, and just tonight the skin looks like it's breaking down a bit. I've lost a bit of faith in my pediatrician, and I'm just not sure what sort of doctor to turn to next.
Thanks for any advice you can give!READ MORE
I just found out my great niece has this and she is having a MRI. If there is a problem it is much better to find it out as soon as possible. I found a good articule at: http://www.nasw.org/users/twoharts/osd.html please check it out. God bless. S.READ MORE
My guess is that it's a "sacral dimple". Akron Children's Hospital has great info on their website:
A sacral dimple or sacral pit, also known as a pilonidal dimple, is an indentation or little hole in the crease between the buttocks and the base of the tailbone. This dimple generally develops as the spinal column is forming inside the mother's womb. To put it simply, if the inner tissues of the neural tube that forms the spinal column become malformed, the outside layer of tissue including the skin may not be smooth. This could mean that the outside layer formed with some dimples in it, which have no effect on the inner layers; or there could be a malformation of the inner layers, which have no effect on the outer layers. So a dimple in the lower back along the spine may be a simple divot in the skin, causing no problems whatsoever, or it may be the sign of malformation in lower tissue layers including the spine and spinal cord.
Most sacral dimples are harmless. However, some sacral pits continue deep inside and may even connect to the spinal canal or even the colon or large intestine. In the latter case, bits of stool can leak out through the opening causing a chronic rash. This type of dimple needs to be closed. Other signs that may indicate an abnormality in the lower spine include large or deep sacral dimples or dimples that are covered by hair or a birthmark.
Most spinal cord defects signaled by a sacral dimple may be adequately investigated by doing a thorough physical exam and, if needed, an ultrasound. For those in which there is a very high suspicion of a spinal cord defect, an MRI is usually performed. If these tests detect a problem affecting the spinal cord, the child may require surgery.
If you notice a deep or an unusual-looking sacral dimple on your infant, be sure to discuss it with your pediatrician.
Some things your pediatrician will look for include:
- Can the floor of the pit or dimple be easily seen? When the bottom portion of a divot can't be seen, this may be an indication of a neural tube that never closed completely.
- Does the pit have hair growing from it? This again makes a pit suspicious for deeper involvement.
- Is the neurologic exam normal? If there is significant involvement of the spinal column, there may be weakness in the legs.
- How high up on the back is the dimple? Most dimples very low on the back (just above the buttocks) are of little concern. The higher the dimple is, the more likely it is to be associated with defects in deeper tissues.
- Are there signs of any other defects? The brain, spinal column, kidneys, as well as other structures form at the same time the neural tube closes. Therefore, if there are any malformations in any other parts of the body, it becomes more probable that the neural tube may be involved as well.
After doing an exam, your child's doctor will discuss what, if any, treatment is needed.READ MORE
- Can the floor of the pit or dimple be easily seen? When the bottom portion of a divot can't be seen, this may be an indication of a neural tube that never closed completely.
A relative had this as well. It fell out tho when the head hair fell out. I think it's just a family trait.READ MORE


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Get Started
1. All the chapters are here.
2. Want to go straight to quizlets? Go here.
3. When you're ready for a practice exam, go here. And remember to hit the restroom before you start.
4. Flashcards: "blah blah blah"
5. Tired of flashcards? Really? Well here's a list of all the words
Ok, if you need to go through this quick and dirty introduction again. You know where to find me.
Please silence your phones. We hope you enjoy the show.
The Investment Advisers Act of 1940 and the Uniform Securities Act define an investment adviser as:
Any person who, for compensation, engages in the business of advising others as the value of securities or the advisability of investing in securities or, as part of a regular business, issues analyses or reports concerning securities.
They define a broker-dealer as:
Any person regularly engaged in the business of effecting transactions in securities for the account of others.
Before we dig too...
Looking for more? Why is this annoying box in the way? It's because you haven't paid for the course yet!


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Paul Garcia: #Spurs just released Summer League roster: Austin Daye, Ryan Richards, Marcus Denmon, Kyle Anderson, Deshaun Thomas on the team
Ryan Richards RumorsAll NBA Players
Ryan Richards
Position: None
Born: 04/21/91
Height: 6-11 / 2.11
Weight:230 lbs. / 104.3 kg.
Born: 04/21/91
Height: 6-11 / 2.11
Weight:230 lbs. / 104.3 kg.
Sittingbourne basketball star Ryan Richards is at the eye of an Olympic storm after defecting from the Great Britain set-up to join Jamaica ahead of the London 2012 Games. The former Medway Park Crusaders star – who was drafted by NBA giants the San Antonio Spurs in 2010 – ended the season playing in the Georgian SuperLeague in a bid to prove his fitness and form before the Olympics. However the 6ft 11inc forward has decided to swap TeamGB for the nation of his father's birth after winning seven senior caps last year. The 21-year-old confirmed to the KM Group: "I'm not involved with GB anymore," but question marks remain about his eligibility under FIBA rules having represented Britain at senior level as well as under-20s.
British big man Ryan Richards will play with Lugano Tigers, in Switzerland, next season. The center born in 1991 and selected by San Antonio Spurs in the 2010 NBA Draft with the 49th overall has already played in Swiss with BBC Monthey in 2009-10 averaging 13.3ppg, 5.2rpg in 6 games.
Mark Woods: Spurs draft pick Ryan Richards confirms he will be having a second shoulder surgery today. Likely now to miss entire season.
Jeff McDonald: Spurs' pick Ryan Richards is in town rehabbing shoulder injury. Expected to return to his Spanish team for next season, eventually.
Ryan Richards, the 49th overall pick in the last NBA draft, will be sent on loan again next season by Gran Canaria 2014. The 19-year-old British forward, in the Spanish team since 2009, was also loaned last season in the Swiss team BBC Monthey, averaging 13.3 points and 5.2 rebounds per game.


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Keynote Themes FX
The Keynote Themes FX 5.0 bundle is designed for your exclusive presentations by a supreme team of professional designers. Share your ideas, proposals, contracts, and solutions; decorate them with matching motion backgrounds, fonts, frames, and bullet styles to make the best of your competitive advantage and to carve your path to the best results. You donât need to worry that the live themes with motion backgrounds may draw your audienceâs attention away from your message. In fact, the contrary is true: the motion themes are styled to lend your presentation a winsome mood.
The Keynote Themes FX 5.0 package includes fifteen motion themes: five are new and innovative (Air Blobs, Crystal Clear, DNA Chain, Glass Beads, and Neuro Threads), and the reminaing ten are the familiar designs from the previous version. Each of the new themes consists of 14 masters, which allow you to choose the most favorable layout for your ideas and illustrations in each slide.
You donât need to study a tutorial or learn how to use the motion themes. Your previous practical knowledge in preparing Keynote slides gives you all the details you need to know. The steps you already useâ"editing and formatting text, choosing shades, placing images, etc.â"are totally sufficient for creating an unconventional presentation. Besides, after you download the package and follow several steps for installation, the themes will automatically appear in the Themes Chooser of Keynote.
Required OS: 10.5
Tags: keynote , presentation , themes , quicktime , motion


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Team GB women denied again by Italy
9th August 2012
The British women's water polo team brought their Olympic adventure to a close with defeat to Italy but left the London 2012 Water Polo Arena with their heads held high.
More agony for battling Brits
7th August 2012
The British women's water polo team suffered their third narrow defeat in five games as they lost to Russia in their 5-8 classification playoff at London 2012.
British men bow out of Games against Montenegro
6th August 2012
The British Men brought their London 2012 Olympic Games Water Polo campaign to a close with a tricky encounter against in-form Montenegro.
Brits fall short after stirring comeback
5th August 2012
The British women put in their performance of the tournament as they staged a last quarter comeback before losing a thrilling quarter-final against Spain at London 2012.
Brits thwarted by ruthless Hungary
4th August 2012
Team GB men's water polo team slipped to defeat in their fourth match of London 2012 against defending champions Hungary.
Brits prepare for Spain after defeat to European champions
3rd August 2012
The Team GB women will face Spain in their first ever Olympic water polo quarter final after defeat to Italy in their final group match of London 2012.
Brits improve again in USA defeat
2nd August 2012
The Team GB men's water polo team put in another spirited performance as they lost to defending silver medallists USA.
Aussies too strong for Brits
1st August 2012
The Team GB Women's Water Polo team lost out to medal-favourites Australia in their second match at London 2012.
Serbia weather spirited British challenge
Gold-medal favourites Serbia recover from an early deficit to hold off Team GB in their men's water polo group match at London 2012.
Impressive Brits cruelly denied by Russia
30th July 2012
Team GB's women water polo team were denied a memorable result by Russia in their opening match at London 2012.


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Police report: July 19, 2013
Published: Thursday, July 18, 2013 at 7:46 p.m.
Last Modified: Thursday, July 18, 2013 at 7:46 p.m.
Portions of the following information are based on facts provided by the arrested individuals. Those individuals have been booked with, not convicted of, the offenses shown. All accused should be presumed innocent until proven guilty.
July 17, 2013
Terrebonne Sheriff's Office
Matthew Craig Egeler, 41, 1194 La. 665, Montegut, failure to appear, speeding, driving under suspension, possession schedule I drug, unlawful possession drug paraphernalia, illegal use of narcotics in presence of juvenile.
Catherine Lecompte Egeler, 40, 1194 La. 665, Montegut, possession schedule I drug, two counts possession schedule IV drug, unlawful possession drug paraphernalia, illegal use of narcotics in presence of juvenile.
Damien Oneal Evans, 30, 11530 Wardline Road, Hammond, holding for other agency.
Robert Anthony Watkins, 34, 607 Egle St., Morgan City, contempt of court.
Renaldo Alton Mitchell, 29, homeless, entry after being forbidden.
Shantell Jennifer Babin, 28, 315 Hummingbird Court, Houma, two counts introducing contraband into correctional center.
Tyeine Lacoat Jones, 35, 440 Authement St., Houma, two counts principal to introducing contraband into correctional center.
Melinda Lorene Adams, 51, 113 Darcey Trailer Court, Houma, bond surrender.
Fuad Sami Ibrahim Hamed, 40, 3509 Lake Lynn Drive, Gretna, drug racketeering activity, money laundering illegal transactions involving drug proceeds, failure to possess drug tax stamp, drug free zone violation, distribution schedule I drug.
Travis Glynn Dufrene, 33, 140 Gonzales Court, Houma, disregarding traffic control signal, hit and run.
Lafourche Sheriff
Randy Toups, 56, 257 E. 93rd, Cut Off, three counts contempt of court.
Thibodaux Police
Illinois Crosby, 28, 118 Half Oak Dr., Thibodaux, contempt of thibodaux city court.
Lauren Oncale, 29, 104 N. 8th St., Thibodaux, domestic abuse battery.
Derrick Carter, 28, 1292 St. Charles St., Thibodaux, two counts contempt of Thibodaux City Court.
July 18, 2013
Lafourche Sheriff
Richard Triggs, 31, 122 Charles Ave., Raceland, contempt of court.
Rynell Nelson, 24, 202 Carol St., Thibodaux, sentence imposed.
Kevin Jackson, 45, 518 Paula Dr., Thibodaux, second offense DWI, speeding, operating under suspension.
Tony Smith, 55, 104 Hackberry St., Thibodaux, contempt of court.
Christopher Ward, 30, 2055 St. Mary St., Thibodaux, two counts contempt of court 2 counts.
Anthony Epps, 44, 427 Triple Oaks, Raceland, contempt of court.
Egerald Triggs, 54, 276 Greenvillie St., Raceland, two counts contempt of court, resisting an officer.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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The identification and isolation of stem cells from human embryos opened the promise of using human cells to more efficiently drive drug discovery and toxicity assessments (1). At some point, stem cells may also be used in regenerative medicine to repopulate or even replace diseased tissues and organs. Human embryonic stem cells (ESCs) can differentiate into any of the 200-plus cell types found in the human body.Unfortunately, human ESCs have their drawbacks. Because of their source, ethical controversy has surrounded ESC research since the cells were first isolated in 1998. Furthermore, as they are derived from surplus embryos from in vitro fertilization procedures, their sources and genetic make-up are unknown, thus limiting their utility for investigating potential compound toxicity in targeted human subpopulations.
Induced pluripotent stem cells (iPSCs), on the other hand, possess the advantages of ESCs, avoid the associated ethical implications, and have the intrinsic ability to be a more flexible cell-based research tool. iPSCs are produced from somatic cells that are induced to a pluripotent state by the incorporation of genetic and small-molecule factors that reprogram the somatic cell to a stem cell (2–4). iPSCs have the same pluripotent capabilities of ESCs and the advantages of originating from individuals with identifiable phenotypes and genotypes, thus enabling the use of targeted human subpopulation models early in drug discovery and toxicity screening.Producing cardiomyocytes from human ESCs and iPSCs using the embryoid body (EB) and directed differentiation methods is well documented (5, 6). The efficiency with which these methods can differentiate ESCs and IPSCs into cardiomyocytes is highly variable, but consistent among both methods is a difficulty in producing highly pure (> 90%) populations of cardiomyocytes. Additional comparisons of cardiomyocyte generation from human ESCs and iPSCs suggest that both starting materials have an equivalent cardiogenic capacity (7), and further molecular and electrophysiological analyses demonstrate that both starting materials produce differentiated cardiomyocytes with phenotypes consistent with atrial, ventricular, and nodal cardiomyocyte subtypes (5, 6).
As described above, human iPSCs have particular advantages over ESCs for drug discovery and toxicity testing when induced to differentiate into a mature cell type. The significant challenge for commercialization of such cells is the ability to consistently produce both starting material iPSCs and the differentiated cells in the quantity, quality, and purity required by the pharmaceutical industry. Here we will describe a process by which we have industrialized the manufacture of iPSC-derived human cardiomyocytes. This process, as currently practiced at Cellular Dynamics International (CDI), is capable of meeting the foreseeable demand for purified iPSC-derived human cardiomyocytes and is scalable by more than two orders of magnitude if necessary without difficulty. We will illustrate the purification process and show that the human cardiomyocytes generated from this process express the same genes, proteins, electrophysiological properties, and responses to cytotoxic substances and ion channel blockers expected of cardiomyocytes.
Manufacture of human iPSCs
iPSCs are developed from human fibroblasts, skin, blood, or other somatic cell types collected from individuals. The purified somatic cells are exposed to reprogramming agents that stimulate de-differentiation into iPSCs. Typically, reprogramming somatic cells is a slow and complicated process to which many investigators have contributed different methodologies (8). Originally, the reprogramming process required genetic modification of the source material with viral vectors that permanently integrate into seemingly random locations within the host DNA. Although the reprogrammed cells exhibited the properties of stem cells, the integrated vectors limited the usefulness of the cells to clinical or drug testing applications because of the perceived potential mutagenic or oncogenic effects of the integrated DNA. New reprogramming methodologies have been developed that largely overcome this barrier (9, 10) so that reprogrammed cells do not have foreign DNA, vector or otherwise, integrated into the genome, thus creating iPSC lines with potential applications in clinical as well as discovery settings.
To prevent entry of iPSC populations cultured under standard conditions into non-directed differentiation pathways, such differentiated cells must be removed and "weeded out" of the population. This weeding step is subjective, labor-intensive, and highly dependent on the skill and attention of the technician. Therefore, to manufacture the necessary number of iPSCs needed to produce terminally differentiated cells for use by the pharmaceutical industry, we have simplified the process to enable standardization and assembled it into a highly parallel structure.
The major production constraint of cell weeding was eliminated by developing a proprietary culture system that a) used standard single-cell splitting techniques to eliminate the need for periodic weeding, and b) added small molecules to the cell cultures to promote survival and proliferation
Scalability was incorporated into the process by building the cell culture system in a highly parallel nature that enabled the production of billions of iPSCs through the use of CellSTACK culture chambers (Corning, Lowell, MA) rather than standard tissue culture or T-flasks. The large surface area to footprint ratio of the CellSTACK system enabled parallel culturing of iPSCs and resulted in a significant expansion in iPSC production. Currently, this "industrialized" process can generate 100 billion or more iPSCs per month with a small team of manufacturing technicians. Because manufacturing is standardized, production levels can be increased through the addition of additional cell-culture manufacturing lines.


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these< retro 7 orian blu
New Videos
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February 16, 2012 BY Brendan Dunne / 14
Despite the moniker, this new Nike Zoom Kobe VII won't help you blend in with your surroundings at all. Quite the opposite in fact, as the color changing upper is sure to break a few necks. That's right, the Nike Zoom Kobe VII 'Invisibility Cloak' slides across a range of shades depending on the angle you look at them from, giving the Black Mamba an extra tool in his arsenal. And while they don't bear the back emblem of any specific animal like other Nike Zoom Kobe VII 'Predator Pack' releases, it's to hard to imagine why Nike passed up on the easy chameleon tie-in. Hit the jump for some new shots of this slick new Kobe colorway, which is hitting in the US on February 18th but will be available tomorrow, the 17th at Titan out in the Phillipines. via SM
Nike Zoom Kobe VII
Black/Court Purple-Turquoise Blue
Filed under: Basketball Kobe Upcoming Sneakers
Tags: Nike Zoom Kobe VII Nike Zoom Kobe VII 'Invisibility Cloak'
these< retro 7 orian blu
I'm from Philippines and they released as worse as quickstrike but they said it was just quickstrike. Everything was sold out few minutes after opening.
Shoes are dope gotta get these
I like the fact that its not label with a 'predator.' seems less commercialized.
Harry Potter wouldn't rock these.
yall posting this need to be posting how the Galaxy pack just released on Nike store a week early http://store.nike.com/us/en_us/?l=shop,pwp,c-1/f-...
where are these going to be at online? anyone know?
I love these
nike store glitches thank god I legit almost had a seizure hahah i was like NOOO WAAAAYYYY FUUCKK
Nikestore there really limited like the KD YOTD
im serious its been taken down but me n my friend both coped kds n lebrons
yotd's aren't so limited..
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A Harlan County man will spend more than a decade behind bars.
Terrill Derry was sentenced to more than 14 years in prison in federal court in London after pleading guilty to child pornography charges this April.
Derry was indicted last October after police say he had a sexually explicit chat with an undercover police officer posing as a 14 year-old girl.
An FBI investigation revealed that Derry had distributed movies and images of child pornography through e-mail.