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Republican primary voters on Tuesday stuck with two incumbent congressmen and gave the nod to a former U.S. Senate candidate, who won the nomination for Colorado's only open congressional seat.
U.S. Reps. Scott Tipton and Doug Lamborn both won nominations for another term — Tipton easily and Lamborn in a close race — while Weld County District Attorney Ken Buck won decisively in the heavily Republican 4th Congressional District in the night's congressional primaries.
The anti-establishment fervor that swept House Majority Leader Eric Cantor from his Virginia seat — with the help of Democrats and unaffiliated voters who cast ballots in that state's open primary earlier this month — appears not to have affected the final results in Colorado, at least not yet.
Buck narrowly lost a race against U.S. Sen. Michael Bennet four years ago — it was the closest Senate race in the country that year — and was among the Republicans running against U.S. Sen. Mark Udall this time around, until U.S. Rep. Cory Gardner jumped into that race and gave up his seat. Buck cruised to a win by a wide margin, coming in ahead of state Sen. Scott Renfroe, R-Greeley, Weld County Commissioner Barbara Kirkmeyer and Larimer County author Steve Laffey, a one-time investment banker and the former mayor of a Rhode Island city.
Buck, who was the favorite to win the Senate nomination before switching races with Gardner, won the House nod with 44.2 percent of the vote, besting Renfroe's 23.9 percent, trailed by Kirkmeyer at 16.4 percent and Laffey with 15.4 percent, in unofficial results reported by the Colorado secretary of state's office at press time.
"I haven't lost a primary yet — I like primaries," Buck told supporters on primary night. "I'm going to work very hard to make sure we come out on top in November."
Buck won a hard-fought primary against former Lt. Gov. Jane Norton — pitting his more tea-party inspired style of conservatism against her establishment brand — in 2010.
Also on Tuesday, Buck's wife, Perry, ran unopposed and secured the nomination to run for a second term in the state House, where she represents a Weld County district.
Democrat Vic Meyers, a Trinidad rancher, is the Democrats nominee for the 4th CD. Libertarian Jess Loban is also on the ballot. Republicans outnumber Democrats in the district, which includes rock-ribbed Douglas County in addition to Weld County and the eastern plains, by nearly 2-to-1.
It's U.S. Rep. Lamborn — barely — in CD 5
U.S. Rep. Doug Lamborn defeated challenger Bentley Rayburn, a retired Air Force major general, in the fourth primary he's had to negotiate in his five runs for the 5th Congressional District seat, anchored by conservative El Paso County. Rayburn garnered 47.5 percent of the vote to Lamborn's 52.5 percent.
Rayburn, who has run for the seat twice before, didn't mount this year's campaign until this spring, when he said county Republicans urged him to take on the incumbent. The challenger assailed Lamborn for failing to take advantage of the rock-ribbed bully pulpit afforded by the typically safe seat and charged that he hadn't done enough to protect veterans, a substantial share of the district's population.
"Our theme Bible verse for our campaign," Rayburn said in a statement after the election, "was Proverbs 21:31 which says, 'The horse is prepared for the day of battle, but the victory belongs to the LORD.' Even though we didn't get the outcome we hoped for, we have been victorious in many ways. We are blessed by the number of supporters and voters we met along the way, who heard and believed in our positive message of exceptional leadership and a brighter more prosperous 5th Congressional District."
Lamborn spent primary election night in Washington to attend a meeting of a conference committee tasked with reconciling House and Senate versions of a bill designed to fix problems with the Veterans Administration, including long waits for health care.
"I take all of my opponents seriously," Lamborn told The Colorado Statesman in an interview. "They always have some kind of credentials that they bring to the table that give them a certain amount of credibility."
Lamborn said he's forging ahead despite what he called a "very frustrating" atmosphere in Washington, where he blamed President Barack Obama for circumventing Congress and said the Senate is standing in the way of legislative solutions to the country's woes.
"The president is on record saying he'll use his pen to work around Congress," Lamborn lamented. "We have a do-nothing Senate. They're hardly sending us any legislation — we've sent them 300 bills that are just sitting there now."
Lamborn's Democratic opponent, retired Air Force Major Gen. Irv Halter, pounced on the incumbent's close call, claiming it demonstrates an opening for a candidate like himself.
"Tonight's results show that thousands of Republicans and Unaffiliated voters across our district are tired of Congressman Lamborn's lack of leadership and accomplishments throughout his 20 years as a career politician," Halter said in a statement. "I am running for office because I believe that our Congress is broken and it is time for new leadership in Washington. This election is not about party; it is about who can change Washington: someone who has been there for years, or someone with a proven record of leadership outside of politics."
National Democrats have said their polling shows that a candidate who matches Halter's description can give Lamborn a run for his money, potentially siphoning off enough disaffected Republicans to flip the district. Halter sought to take advantage of that possibility on primary night.
"For the Republicans and unaffiliated voters who cast a ballot for Bentley Rayburn, I too agree that our district has been underserved by a congressman who has become part of the problem in Washington. I share your frustration that we lack a leader who will engage with his constituents — especially the local business community," Halter said.
Tipton has no problem beating challenger
In the 3rd District, U.S. Rep. Scott Tipton handily dispatched challenger David Cox, the Palisade peach grower who surprised the two-term incumbent by winning a spot on the ballot at the April district assembly. Tipton got 74.6 percent of the vote in unofficial results, nearly three times the 25.4 percent won by Cox, to run for a third term representing the district, which covers the Western Slope and Pueblo County.
Before first winning the seat in 2010, Tipton defeated tea-party-backed attorney Bob McConnell, who, like Cox, assailed the owner of a pottery company in Cortez as insufficiently conservative. Tipton went on to unseat U.S. Rep. John Salazar in the general election.
Former state Sen. Abel Tapia, D-Pueblo, is the Democratic nominee for the 3rd CD. Unaffiliated candidate Tisha Casida is also running for the seat.
The state's three Democratic members of Congress, U.S. Reps. Diana DeGette, Jared Polis and Ed Perlmutter, and the third incumbent Republican seeking reelection, U.S. Rep. Mike Coffman, were all nominated without opposition, as were their opponents. Republicans Martin Walsh will be running against DeGette in the 1st CD; George Leing takes on Polis in the 2nd CD; and Don Ytterberg will be on the ballot vs. Perlmutter in the 7th CD. Former House Speaker Andrew Romanoff, D-Denver, is officially the Democratic nominee to face Coffman in the 6th CD in one of the marquee congressional races in the country.
— firstname.lastname@example.com


text:
Definition of instill in English:
(British also instil)
verb[with object]
1Gradually but firmly establish (an idea or attitude, especially a desirable one) in a person's mind: how do we instill a sense of rightness in today's youth?
More example sentences
- A strong nationalist belief was instilled in each and every member of the family.
- We know how much, for instance, racism is instilled in people's minds to create divisions.
- It is vital to instill an attitude of fitness at a young age.
inculcate, implant, ingrain, impress, imprint, introduce;
engender, produce, generate, induce, inspire, promote, foster;
drum (into), drill (into)
imbue, inspire, infuse, inculcate, inject;
2Put (a substance) into something in the form of liquid drops: she was told how to instill eye drops
More example sentences
- The drops are instilled to locally anesthetize the surgical eye and reduce the blink reflex in both eyes.
- The circulating nurse instills tetracaine hydrochloride drops to decrease the burning sensation of the diluted povidone-iodine solution.
- Fluid is instilled around the veins, and they are then illuminated from beneath the skin with a powerful light source.
- Example sentences
- From Wingate, Dayan learned the importance of surprise, cunning, compassion and the instillation of fear.
- To quantitate the magnitude of neutrophilic lung inflammation, we investigated the cellular profile of BAL fluid of the lungs 24 hours after the intratracheal instillations.
- In 20 healthy volunteers one dose of a 1-percent forskolin solution had no effect, whereas two instillations five minutes apart led to significant decreases in IOP and aqueous flow rate.
instillment noun
- Example sentences
- Goals include approval and instilment of general principles for professional ethics in fields of traditional and folk medicine and healing.
Late Middle English (sense 2): from Latin instillare, from in- 'into' + stillare 'to drop' (from stilla 'a drop').
For editors and proofreaders
Syllabification: in·still
Definition of instill in:
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= trending

subset: commoncrawl


text:
Greely avenged an earlier loss to Falmouth and Mt. Ararat picked up their first win of the year against rival Brunswick.
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In this photo taken Feb. 23, 2013, and provided by Gulfstream Park, Orb, ridden by John R. Velazquez, heads to the finish line to win the Fountain of Youth stakes horse race at Gulfstream Park in Hallandale Beach, Fla. Trainer Shug McGaughey catches Derby fever every now and then, like every decade or so, and he just might have it again after Orb won the Fountain of Youth. The 3-year-old colt moves into the AP's latest Run to the Roses list of Top 10 Kentucky Derby contenders.(AP Photo/Gulfstream Park)


text: Tale of two UT quarterbacks can only continue for so long Back to Article Comments Need to Register? X Remember Me Forgot your password? Today's Deals Catlina Women's Swimsuit Bottoms for $8 + pickup at Walmart Stanley FatMax 8A Battery Charger for $20 + pickup at Walmart Serta Massage Recliner for $249 + free shipping Keter Manor 4x6-Foot Storage Shed for $326 + pickup at Walmart Powered by


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'Pentatonix' 'Daft Punk Medley'
Daft Punk is helping Pentatonix to "Get Lucky."
Pentatonix, a five-man a cappella group which won season three of NBC's "The Sing-Off," recently released "Daft Punk Medley," a nearly five minute video that's been viewed over a million times since it dropped on YouTube at midnight Tuesday.
It's a compilation of the French electronic music duo's songs, but recorded with only vocals, no instruments. The accompanying video, of which each of Pentatonix's members created their own look — blue contacts as sole unifying characteristic — "was a little more intense than our older stuff, a little creepy," said Scott Hoying, one of the group's lead vocalists.
Although Pentatonix has covered the likes of Lorde and Beyonce, Hoying said the outline for Daft Punk took a week, whereas their other covers have been outlined and executed, on average, in three days.
The medley serves as the closing track on their newly released album, "PTX Vol. II" which is currently No. 17 on the iTunes top 100 albums chart.
"A capella is hard to sell," according to Hoying, who said the "Daft Punk Medley" has already added close to 40,000 subscribers to the group's YouTube channel. "It's a really underrated genre but something that can sound full and epic. We're just trying to share it everywhere."
Pentatonix is made up of Hoying, Kirstie Maldonado, Mitch Grassi, Avi Kaplan and Kevin Olusola, all of whom met one another for the first time hours before they auditioned for "The Sing-Off."
Watch the video here. What do you think of "Daft Punk Medley?" Leave your thoughts in the comments and follow @alexandracheney for more music news.


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the word 'fleeb' can be used in many different ways. It can be used to describe someone as incredibly awesome and amazing or it can just be one of those words people say for no apparent reason.
To describe someone as incredibly awesome and awesome: "That's so FLEEB!!!"
"You're so fleeb!"
Just saying 'fleeb' for no apparent reason:
"fleeb fairy!"
"You're so fleeb!"
Just saying 'fleeb' for no apparent reason:
"fleeb fairy!"
додав whatthemeaningoflife 12 Лютого 2013
Trending Now
Can you define these popular missing words?
Top Definition
A complete idiot.
Your mother is a total fleeb.
додав Allie 19 Листопада 2003
In the Lego community, a space creature that chews through metal, etc. Resembles a scorpion with a shallow dome on it's back.
"Look out! A fleeb! Don't let it chew up the ship engi- *BOOM!*
Too late."
Too late."
додав Shadowviking 24 Серпня 2007
a word that didn't quite make it as a synonym for tool or douche bag mainly for the fact that the people who say it are tools themselves.
Wow, what a fleeb
додав lawlwotevr 04 Січня 2009
Fleebing is an act of completely inhaling anything, although mainly food.
Guy 1: That pizza was delicious.
Guy 2: I know, I totally fleebed it!
Guy 2: I know, I totally fleebed it!
додав Dolus 03 Січня 2012
An act of excitement
35 mins until Big Brother comes on! *fleebs*
додав Smasher513 22 Липня 2009
a word to say when conversation is low
uh...FLEEB! hewhehehehehehehe!
додав Fleeb-a-dibba-dibba! 28 Листопада 2003


text:
Low-profile tires do not inherently wear out quicker because of their sidewall height. Most do wear out faster, though, because the majority of low-profile tires are high-performance.
High-performance tires use a softer tire compound that is more prone to wear than an all-season tire. There are all-season low-profile tires, but the majority are summer or performance tires.
Low-profiles are often fitted on sportier cars that can make full use of the handling advantage — and trust us, when you're taking advantage of a car's handling capabilities, the tread will wear out much quicker than you'd expect.
The National Highway Traffic Safety Administration sets standards on tread wear ratings, called Uniform Tire Quality Grading System, which also rates traction performance and temperature resistance. These ratings are found on the tire's sidewall. The tread wear rating will give you a rough estimate on how fast the tires will wear. Below is an entry from the Cars.com Glossary on tire tread life, temperature and traction ratings. Use these ratings while tire shopping to get an idea of the tire's overall quality and life expectancy. While NHTSA and DOT sets the standards, tire manufacturers perform the tests.
Tire Quality Grading
The following three codes are part of the U.S. Department of Transportation's uniform tire quality grading system:
Tread wear: Uses numbers from 100 to 500. A tire rated 150 would have 50 percent more mileage than a tire rated 100 if used in the same conditions.
Temperature: Uses letter grades A, B and C, with A representing the best resistance to heat generation and C the least. C is the lowest permissible rating.
Traction: Also uses A, B and C, with A being the best traction — based on wet road use — and C the least.
Learn more
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Your question has been successfully submitted to Ask.cars.com. It will now be reviewed by our editors and we'll answer it soon if we think it's a useful question. You will be notified via e-mail when the answer is posted. Ask.cars.com tackles your questions about new cars and the car-buying process. Unfortunately we can't answer questions regarding:
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Take gaming to the next level. With a Lexar Gaming memory card, you can download, save, and manage all your gaming data. The cards allow you to save your progress in a game, keep custom settings, and safeguard your high scores—so you can unleash the power of your gaming device. Available in Memory Stick PRO Duo™ and SDHC™ formats, Lexar Gaming memory cards give you the ability to transfer, store, and play a large amount of gaming and multimedia content.
Versatile, high-speed file transfer solution.


text:
- 1. Name of the medicinal product
- 2. Qualitative and quantitative composition
- 3. Pharmaceutical form
- 4. Clinical particulars
- 4.1 Therapeutic indications
- 4.2 Posology and method of administration
- 4.3 Contraindications
- 4.4 Special warnings and precautions for use
- 4.5 Interaction with other medicinal products and other forms of interaction
- 4.6 Fertility, pregnancy and lactation
- 4.7 Effects on ability to drive and use machines
- 4.8 Undesirable effects
- 4.9 Overdose
- 5. Pharmacological properties
- 5.1 Pharmacodynamic properties
- 5.2 Pharmacokinetic properties
- 5.3 Preclinical safety data
- 6. Pharmaceutical particulars
- 6.1 List of excipients
- 6.2 Incompatibilities
- 6.3 Shelf life
- 6.4 Special precautions for storage
- 6.5 Nature and contents of container
- 6.6 Special precautions for disposal and other handling
- 7. Marketing authorisation holder
- 8. Marketing authorisation number(s)
- 9. Date of first authorisation/renewal of the authorisation
- 10. Date of revision of the text
Method of administrationOral use
PosologyHow to take QlairaTablets must be taken in the order directed on the package every day at about the same time with some liquid as needed. Tablet taking is continuous. One tablet is to be taken daily for 28 consecutive days. Each subsequent pack is started the day after the last tablet of the previous wallet. Withdrawal bleeding usually starts during the intake of the last tablets of a wallet and may not have finished before the next wallet is started. In some women, the bleeding starts after the first tablets of the new wallet are taken.
How to start Qlaira• No preceding hormonal contraceptive use (in the past month)Tablet-taking has to start on day 1 of the woman's natural cycle (i.e. the first day of her menstrual bleeding). • Changing from a combined hormonal contraceptive (combined oral contraceptive /COC), vaginal ring, or transdermal patchThe woman should start with Qlaira on the day after the last active tablet (the last tablet containing the active substances) of her previous COC. In case a vaginal ring or transdermal patch has been used, the woman should start using Qlaira on the day of removal. • Changing from a progestogen-only method (progestogen-only pill, injection, implant) or from a progestogen-releasing intrauterine system (IUS) The woman may switch any day from the progestogen-only pill (from an implant or the IUS on the day of its removal, from an injectable when the next injection would be due), but should in all of these cases be advised to additionally use a barrier method for the first 9 days of tablet-taking. • Following first-trimester abortion The woman may start immediately. When doing so, she needs not take additional contraceptive measures.• Following delivery or second-trimester abortion For breastfeeding women see section 4.6. Women should be advised to start at day 21 to 28 after delivery or second-trimester abortion. When starting later, the woman should be advised to additionally use a barrier method for the first 9 days of tablet-taking. However, if intercourse has already occurred, pregnancy should be excluded before the actual start of COC use or the woman has to wait for her first menstrual period.
Management of missed tabletsMissed (white) placebo tablets can be disregarded. However, they should be discarded to avoid unintentionally prolonging the interval between active-tablet taking.The following advice only refers to missed active tablets:If the woman is less than 12 hours late in taking any tablet, contraceptive protection is not reduced. The woman should take the tablet as soon as she remembers and should take further tablets at the usual time.If she is more than 12 hours late in taking any tablet, contraceptive protection may be reduced. The woman should take the last missed tablet as soon as she remembers, even if this means taking two tablets at the same time. She then continues to take tablets at her usual time.Depending on the day of the cycle on which the tablet has been missed (see chart below for details), back-up contraceptive measures (e.g. a barrier method such as a condom) have to be used according to the following principles:
|Color Content of estradiol valerate (EV)/dienogest (DNG)
|Principles to follow if missing one tablet for more than 12 hours:
|1 2
|Dark yellow tablets (3.0 mg EV)
|- Take missed tablet immediately and the following tablet as usual (even if this means taking two tablets on the same day) - Continue with tablet-taking in the normal way - Use back-up contraception for the next 9 days
|3 - 7
|Medium red tablets (2.0 mg EV + 2.0 mg DNG)
|8 17
|Light yellow tablets (2.0 mg EV + 3.0 mg DNG)
|18 24
|Light yellow tablets (2.0 mg EV + 3.0 mg DNG)
|- Discard current wallet, and start immediately with the first pill of a new wallet - Continue with tablet-taking in the normal way - Back-up contraception for the next 9 days
|25 26
|Dark red tablets (1.0 mg EV)
|- Take missed tablet immediately and the following tablet as usual (even if this means taking two tablets on the same day) - No back-up contraception necessary
|White tablets (Placebos)
|- Discard missed tablet and continue tablet-taking in the normal way - No back-up contraception necessary
Advice in case of gastro-intestinal disturbancesIn case of severe gastro-intestinal disturbances (e.g., vomiting or diarrhoea), absorption may not be complete and additional contraceptive measures should be taken. If vomiting occurs within 3-4 hours after active tablet-taking, the next tablet should be taken as soon as possible. This tablet should be taken within 12 hours of the usual time of tablet-taking, if possible. If more than 12 hours elapse, the advice concerning missed tablets, as given in section 4.2 Management of missed tablets, is applicable. If the woman does not want to change her normal tablet-taking schedule, she has to take the corresponding tablet(s) needed from another pack. Additional information on special populationsChildren and adolescents No data available for use in adolescents below 18 years. Geriatric patients Qlaira is not indicated after menopause. Patients with hepatic impairment Qlaira is contraindicated in women with severe hepatic diseases. See also section 4.3. Patients with renal impairment Qlaira has not been specifically studied in renally impaired patients.
|• diabetes mellitus with vascular symptoms • severe hypertension • severe dyslipoproteinaemia
WarningsIf any of the conditions or risk factors mentioned below is present, the suitability of Qlaira should be discussed with the woman.In the event of aggravation, or first appearance of any of these conditions or risk factors, the woman should be advised to contact her doctor to determine whether the use of Qlaira should be discontinued.In case of suspected or confirmed VTE or ATE, CHC use should be discontinued. In case anticoagulant therapy is started, adequate alternative contraception should be initiated because of the teratogenicity of anticoagulant therapy (coumarins).No epidemiological studies on the effects of estradiol/ estradiol valerate containing COC's exist. All the following warnings and precautions are derived from clinical and epidemiological data of ethinyl estradiol containing COCs. Whether these warning and precautions apply to Qlaira is unknown.• Circulatory Disorders
Risk of venous thromboembolism (VTE)The use of any combined hormonal contraceptive (CHC) increases the risk of venous thromboembolism (VTE) compared with no use. Products that contain levonorgestrel, norgestimate or norethisterone are associated with the lowest risk of VTE. It is not yet known how the risk with Qlaira compares with these lower risk products. The decision to use any product other than one known to have the lowest VTE risk should be taken only after a discussion with the woman to ensure she understands the risk of VTE with CHCs, how her current risk factors influence this risk, and that her VTE risk is highest in the first ever year of use. There is also some evidence that the risk is increased when a CHC is re-started after a break in use of 4 weeks or more.In women who do not use a CHC and are not pregnant about 2 out of 10,000 will develop a VTE over the period of one year. However, in any individual woman the risk may be far higher, depending on her underlying risk factors (see below).Epidemiological studies in women who use low dose (<50 μg ethinylestradiol) combined hormonal contraceptives have found that out of 10,000 women between about 6 and 12 will develop a VTE in one year It is estimated that out of 10,000 women who use a levonorgestrel-containing CHC about 61 will develop a VTE in one year. It is not yet known how the risk of VTE with CHCs that contain dienogest in combination with estradiol compares with the risk with low dose levonorgestrel-containing CHCs.The number of VTEs per year with low dose CHCs is fewer than the number expected in women during pregnancy or in the postpartum period. VTE may be fatal in 1-2% of the cases.Extremely rarely, thrombosis has been reported to occur in CHC users in other blood vessels, e.g. hepatic, mesenteric, renal or retinal veins and arteries.
Risk factors for VTEThe risk for venous thromboembolic complications in CHC users may increase substantially in a woman with additional risk factors, particularly if there are multiple risk factors (see table).Qlaira is contraindicated if a woman has multiple risk factors that put her at high risk of venous thrombosis (see section 4.3). If a woman has more than one risk factor, it is possible that the increase in risk is greater than the sum of the individual factors in this case her total risk of VTE should be considered. If the balance of benefits and risks is considered to be negative a CHC should not be prescribed (see section 4.3).
Table: Risk factors for VTE
|Risk factor
|Obesity (body mass index over 30 kg/m²)
|Risk increases substantially as BMI rises. Particularly important to consider if other risk factors also present.
|Prolonged immobilisation, major surgery, any surgery to the legs or pelvis, neurosurgery, or major trauma Note: temporary immobilisation including air travel >4 hours can also be a risk factor for VTE, particularly in women with other risk factors
|In these situations it is advisable to discontinue use of the pill (in the case of elective surgery at least four weeks in advance) and not resume until two weeks after complete remobilisation. Another method of contraception should be used to avoid unintentional pregnancy. Antithrombotic treatment should be considered if Qlaira has not been discontinued in advance.
|Positive family history (venous thromboembolism ever in a sibling or parent especially at a relatively early age e.g. before 50).
|If a hereditary predisposition is suspected, the woman should be referred to a specialist for advice before deciding about any CHC use
|Other medical conditions associated with VTE
|Cancer, systemic lupus erythematosus, haemolytic uraemic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis) and sickle cell disease
|Increasing age
|Particularly above 35 years
Symptoms of VTE (deep vein thrombosis and pulmonary embolism)In the event of symptoms women should be advised to seek urgent medical attention and to inform the healthcare professional that she is taking a CHC.Symptoms of deep vein thrombosis (DVT) can include:o unilateral swelling of the leg and/or foot or along a vein in the lego pain or tenderness in the leg which may be felt only when standing or walkingo increased warmth in the affected leg; red or discoloured skin on the leg.Symptoms of pulmonary embolism (PE) can include:o sudden onset of unexplained shortness of breath or rapid breathingo sudden coughing which may be associated with haemoptysiso sharp chest paino severe light headedness or dizzinesso rapid or irregular heartbeat.Some of these symptoms (e.g. shortness of breath, coughing) are non-specific and might be misinterpreted as more common or less severe events (e.g. respiratory tract infections).Other signs of vascular occlusion can include: sudden pain, swelling and slight blue discoloration of an extremity. If the occlusion occurs in the eye symptoms can range from painless blurring of vision which can progress to loss of vision. Sometimes loss of vision can occur almost immediately.
Risk of arterial thromboembolism (ATE)Epidemiological studies have associated the use of CHCs with an increased risk for arterial thromboembolism (myocardial infarction) or for cerebrovascular accident (e.g. transient ischaemic attack, stroke). Arterial thromboembolic events may be fatal.
Risk factors for ATEThe risk of arterial thromboembolic complications or of a cerebrovascular accident in CHC users increases in women with risk factors (see table). Qlaira is contraindicated if a woman has one serious or multiple risk factors for ATE that puts her at high risk of arterial thrombosis (see section 4.3). If a woman has more than one risk factor, it is possible that the increase in risk is greater than the sum of the individual factors - in this case her total risk should be considered. If the balance of benefits and risks is considered to be negative a CHC should not be prescribed (see section 4.3).
Table: Risk factors for ATE
|Risk factor
|Increasing age
|Particularly above 35 years
|Women should be advised not to smoke if they wish to use a CHC. Women over 35 who continue to smoke should be strongly advised to use a different method of contraception.
|Obesity (body mass index over 30 kg/m2)
|Risk increases substantially as BMI increases. Particularly important in women with additional risk factors
|Positive family history (arterial thromboembolism ever in a sibling or parent especially at relatively early age e.g. below 50).
|If a hereditary predisposition is suspected, the woman should be referred to a specialist for advice before deciding about any CHC use
|An increase in frequency or severity of migraine during CHC use (which may be prodromal of a cerebrovascular event) may be a reason for immediate discontinuation
|Other medical conditions associated with adverse vascular events
|Diabetes mellitus, hyperhomocysteinaemia, valvular heart disease and atrial fibrillation, dyslipoproteinaemia and systemic lupus erythematosus.
Symptoms of ATEIn the event of symptoms women should be advised to seek urgent medical attention and to inform the healthcare professional that she is taking a CHC.Symptoms of a cerebrovascular accident can include:o sudden numbness or weakness of the face, arm or leg, especially on one side of the bodyo sudden trouble walking, dizziness, loss of balance or coordinationo sudden confusion, trouble speaking or understandingo sudden trouble seeing in one or both eyeso sudden, severe or prolonged headache with no known causeo loss of consciousness or fainting with or without seizure.Temporary symptoms suggest the event is a transient ischaemic attack (TIA).Symptoms of myocardial infarction (MI) can include:o pain, discomfort, pressure, heaviness, sensation of squeezing or fullness in the chest, arm, or below the breastboneo discomfort radiating to the back, jaw, throat, arm, stomacho feeling of being full, having indigestion or chokingo sweating, nausea, vomiting or dizzinesso extreme weakness, anxiety, or shortness of breatho rapid or irregular heartbeats.• TumoursAn increased risk of cervical cancer in long-term users of COCs (> 5 years) has been reported in some epidemiological studies, but there continues to be controversy about the extent to which this finding is attributable to the confounding effects of sexual behaviour and other factors such as human papilloma virus (HPV).A meta-analysis from 54 epidemiological studies reported that there is a slightly increased relative risk (RR = 1.24) of having breast cancer diagnosed in women who are currently using COCs. The excess risk gradually disappears during the course of the 10 years after cessation of COC use. Because breast cancer is rare in women under 40 years of age, the excess number of breast cancer diagnoses in current and recent COC users is small in relation to the overall risk of breast cancer. These studies do not provide evidence for causation. The observed pattern of increased risk may be due to an earlier diagnosis of breast cancer in COC users, the biological effects of COCs or a combination of both. The breast cancers diagnosed in ever-users tend to be less advanced clinically than the cancers diagnosed in never-users.In rare cases, benign liver tumours, and even more rarely, malignant liver tumours have been reported in users of COCs. In isolated cases, these tumours have led to life-threatening intra-abdominal hemorrhages. A hepatic tumour should be considered in the differential diagnosis when severe upper abdominal pain, liver enlargement or signs of intra-abdominal hemorrhage occur in women taking COCs.• Other conditionsWomen with hypertriglyceridaemia, or a family history thereof, may be at an increased risk of pancreatitis when using COCs.Although small increases in blood pressure have been reported in many women taking COCs, clinically relevant increases are rare. However, if a sustained clinically significant hypertension develops during the use of a COC then it is prudent for the physician to withdraw the COC and treat the hypertension. Where considered appropriate, COC use may be resumed if normotensive values can be achieved with antihypertensive therapy. The following conditions have been reported to occur or deteriorate with both pregnancy and COC use, but the evidence of an association with COC use is inconclusive: jaundice and/or pruritus related to cholestasis; gallstone formation; porphyria; systemic lupus erythematosus; hemolytic uremic syndrome; Sydenham's chorea; herpes gestationis; otosclerosis-related hearing loss.In women with hereditary angioedema exogenous estrogens may induce or exacerbate symptoms of angioedema. Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal. Recurrence of cholestatic jaundice which occurred first during pregnancy or previous use of sex steroids necessitates the discontinuation of COCs.Although COCs may have an effect on peripheral insulin resistance and glucose tolerance, there is no evidence for a need to alter the therapeutic regimen in diabetics using low-dose COCs (containing <0.05 mg ethinylestradiol). However, diabetic women should be carefully observed while taking COCs, particularly in the early stage of COC use.Worsening of endogenous depression, of epilepsy, of Crohn's disease and of ulcerative colitis has been reported during COC use.Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum. Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation whilst taking COCs. Estrogens may cause fluid retention, and therefore patients with cardiac or renal dysfunction should be carefully observed. Patients with terminal renal insufficiency should be closely observed, since the level of circulating estrogens may be increased after administration of Qlaira.This medicinal product contains not more than 50 mg lactose per tablet. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption who are on a lactose-free diet should take this amount into consideration.
Medical examination/consultationPrior to the initiation or reinstitution of Qlaira a complete medical history (including family history) should be taken and pregnancy must be ruled out. Blood pressure should be measured and a physical examination should be performed, guided by the contra-indications (see section 4.3) and warnings (see section 4.4). It is important to draw a woman's attention to the information on venous and arterial thrombosis, including the risk of Qlaira compared with other CHCs, the symptoms of VTE and ATE, the known risk factors and what to do in the event of a suspected thrombosis.The woman should also be instructed to carefully read the user leaflet and to adhere to the advice given. The frequency and nature of examinations should be based on established practice guidelines and be adapted to the individual woman.Women should be advised that hormonal contraceptives do not protect against HIV infections (AIDS) and other sexually transmitted diseases.
Reduced efficacyThe efficacy of COCs may be reduced for example in the following events: missed active tablets (section 4.2), gastro-intestinal disturbances (section 4.2) during active tablet taking or concomitant medication (section 4.5).
Cycle controlWith all COCs, irregular bleeding (spotting or breakthrough bleeding) may occur, especially during the first months of use. Therefore, the evaluation of any irregular bleeding is only meaningful after an adaptation interval of about 3 cycles. Based on patient diaries from a comparative clinical trial, the percentage of women per cycle experiencing intracyclic bleeding was 10 18 % for women using Qlaira. Users of Qlaira may experience amenorrhea although not being pregnant. Based on patient diaries, amenorrhea occurs in approximately 15% of cycles.If Qlaira has been taken according to the directions described in Section 4.2, it is unlikely that the woman is pregnant. If Qlaira has not been taken according to these directions prior to the first missed withdrawal bleed or if the withdrawal bleeding is missed in two consecutive cycles, pregnancy must be ruled out before Qlaira use is continued. If bleeding irregularities persist or occur after previously regular cycles, then non-hormonal causes should be considered and adequate diagnostic measures are indicated to exclude malignancy or pregnancy. These may include curettage. 1 Mid-point of range of 5-7 per 10,000 WY, based on a relative risk for CHCs containing levonorgestrel versus non-use of approximately 2.3 to 3.6
ManagementEnzyme induction can already be observed after a few days of treatment. Maximal enzyme induction is generally seen within a few weeks. After the cessation of drug therapy enzyme induction may be sustained for about 4 weeks.
Short-term treatmentWomen on treatment with enzyme-inducing drugs should temporarily use a barrier method or another method of contraception in addition to the COC. The barrier method must be used during the whole time of the concomitant drug therapy and for 28 days after its discontinuation. If the drug therapy runs beyond the end of the active tablets in the COC pack, the placebo tablets must be discarded and the next COC pack should be started right away.
Long-term treatmentIn women on long-term treatment with hepatic enzyme-inducing active substances, another reliable, non-hormonal, method of contraception is recommended.
Substances increasing the clearance of COCs (diminished efficacy of COCs by enzyme-induction), e.g.:Barbiturates, carbamazepine, phenytoin, primidone, rifampicin, and HIV medication ritonavir, nevirapine and efavirenz and possibly also felbamate, griseofulvin, oxcarbazepine, topiramate and products containing the herbal remedy St. John's Wort (hypericum perforatum).In a clinical study the strong cytochrome P450 (CYP 3A4) inducer rifampicin led to significant decreases in steady state concentrations and systemic exposures of dienogest and estradiol. The AUC (0-24h) of dienogest and estradiol at steady state, were decreased by 83% and 44%, respectively.
Substances with variable effects on the clearance of COC:When co-administered with COCs, many combinations of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors, including combinations with HCV inhibitors can increase or decrease plasma concentrations of estrogen or progestins. The net effect of these changes may be clinically relevant in some cases.Therefore, the prescribing information of concomitant HIV/HCV medications should be consulted to identify potential interactions and any related recommendations. In case of any doubt, an additional barrier contraceptive method should be used by women on protease inhibitor or non-nucleoside reverse transcriptase inhibitor therapy.Substances decreasing the clearance of COCs (enzyme inhibitors):Dienogest is a substrate of CYP3A4. The clinical relevance of potential interactions with enzyme inhibitors remains unknown. Concomitant administration of strong CYP3A4 inhibitors can increase plasma concentrations of the estrogen or the progestin or both. Coadministration with the strong CYP3A4 enzyme inhibitor ketoconazole resulted in a 2.9-fold and 1.6-fold increase of AUC (0-24h) at steady state for dienogest and estradiol, respectively. Concomitant administration of the moderate inhibitor erythromycin increased the AUC (0-24h) of dienogest and estradiol at steady state by 1.6-fold and 1.3-fold, respectively. • Effects of Qlaira on other medicinal productsOral contraceptives may affect the metabolism of certain other active substances. Accordingly, plasma and tissue concentrations may either increase (e.g. cyclosporin) or decrease (e.g. lamotrigine).Pharmacokinetics of nifedipine were not affected by concomitant administration of 2 mg dienogest + 0.03 mg ethinyl estradiol thus confirming results of in vitro studies indicating that inhibition of CYP enzymes by Qlaira is unlikely at the therapeutic dose.• Other forms of interactions
Laboratory testsThe use of contraceptive steroids may influence the results of certain laboratory tests, including biochemical parameters of liver, thyroid, adrenal and renal function, plasma levels of (carrier) proteins, e.g. corticosteroid binding globulin and lipid/lipoprotein fractions, parameters of carbohydrate metabolism and parameters of coagulation and fibrinolysis. Changes generally remain within the normal laboratory range.
PregnancyQlaira should not be used during pregnancy.If pregnancy occurs during use of Qlaira, further intake must be stopped. However, extensive epidemiological studies with ethinylestradiol containing COCs have revealed neither an increased risk of birth defects in children born to women who used COCs prior to pregnancy, nor a teratogenic effect when COCs were taken inadvertently during pregnancy. Animal studies do not indicate a risk for reproductive toxicity (see section 5.3). The increased risk of VTE during the postpartum period should be considered when re-starting Qlaira (see section 4.2 and 4.4).
BreastfeedingLactation may be influenced by COCs as they may reduce the quantity and change the composition of breast milk. Therefore, the use of COCs should generally not be recommended until the nursing mother has completely weaned her child. Small amounts of the contraceptive steroids and/or their metabolites may be excreted with the milk. These amounts may affect the child.
FertilityQlaira is indicated for the prevention of pregnancy. For information on return to fertility, see section 5.1.
|System Organ Class
|Common (≥ 1/100 to <1/10)
|Uncommon (≥ 1/1,000 to <1/100)
|Rare (≥ 1/10,000 to < 1/1,000)
|Infections and infestations
|Fungal infection Vulvovaginal mycotic infection1Vaginal infection
|Candidiasis Oral herpes Pelvic inflammatory disease Presumed ocular histoplasmosis syndrome Tinea versicolor Urinary tract infection Vaginitis bacterial
|Metabolism and nutrition disorders
|Increased appetite
|Fluid retention Hypertriglyceridaemia
|Psychiatric disorders
|Depression/depressed mood Emotional disorder2Insomnia Libido decreased3Mental disorder Mood change4
|Aggression Anxiety Dysphoria Libido increased Nervousness Nightmare Restlessness Sleep disorder Stress
|Nervous system disorders
|Dizziness Migraine6
|Disturbance in attention Paraesthesia Vertigo
|Eye disorders
|Contact lens intolerance Dry eye Eye swelling
|Cardiac disorders
|Myocardial infarction Palpitations
|Vascular disorders
|Hot flush Hypertension
|Bleeding varicose vein Venous thromboembolism (VTE) Arterial thromboembolism (ATE) Hypotension Phlebitis superficialis Vein pain
|Gastrointestinal disorders
|Abdominal pain7Nausea
|Diarrhoea Vomiting
|Constipation Dry mouth Dyspepsia Gastrooesophageal reflux disease
|Hepatobiliary disorders
|Liver enzymes increased8
|Focal nodular hyperplasia of the liver Cholecystitis chronic
|Skin and subcutaneous tissue disorders
|Alopecia Hyperhidrosis Pruritus10Rash11
|Allergic skin reaction12Chloasma Dermatitis Hirsutism Hypertrichosis Neurodermatitis Pigmentation disorder Seborrhoea Skin disorder13
|Musculoskeletal and connective tissue disorders
|Muscle spasms
|Back pain Pain in jaw Sensation of heaviness
|Renal and urinary disorders
|Urinary tract pain
|Reproductive system and breast disorders
|Amenorrhea Breast discomfort14Dysmenorrhoea Intracyclic bleeding (Metrorrhagia)15
|Breast enlargement16Breast mass Cervical dysplasia Dysfunctional uterine bleeding Dyspareunia Fibrocystic breast disease Menorrhagia Menstrual disorder Ovarian cyst Pelvic pain Premenstrual syndrome Uterine leiomyoma Uterine spasm Uterine/ vaginal bleeding incl. spotting17Vaginal discharge Vulvovaginal dryness
|Abnormal withdrawal bleeding Benign breast neoplasm Breast cancer in situ Breast cyst Breast discharge Cervical polyp Cervix erythema Coital bleeding Galactorrhea Genital discharge Hypomenorrhoea Menstruation delayed Ovarian cyst ruptured Vaginal odour Vulvovaginal burning sensation Vulvovaginal discomfort
|Blood and lymphatic system disorders
|Respiratory, thoracic and mediastinal disorders
|Asthma Dyspnoea Epistaxis
|General disorders and administration site conditions
|Fatigue Irritability Oedema18
|Chest pain Malaise Pyrexia
|Weight increased
|Weight decreased Blood pressure changes19
|Smear cervix abnormal
Description of selected adverse reactionsAn increased risk of arterial and venous thrombotic and thrombo-embolic events, including myocardial infarction, stroke, transient ischemic attacks, venous thrombosis and pulmonary embolism has been observed in women using CHCs, which are discussed in more detail in section 4.4.Occurrence of amenorrhea and intracyclic bleeding based on patient diaries is summarized in section 4.4 Cycle control.The following serious adverse events have been reported in women using COCs, which are discussed in section 4.4 Special warning and precautions for use: Tumours- The frequency of diagnosis of breast cancer is very slightly increased among COC users. As breast cancer is rare in women under 40 years of age the excess number is small in relation to the overall risk of breast cancer. Causation with COC use is unknown. For further information, see sections 4.3 and 4.4;- Liver tumours; Other conditions- Erythema nodosum, Erythema multiforme; - Breast discharge;- Hypertension;- Occurrence or deterioration of conditions for which association with COC use is not conclusive: Crohn's disease, ulcerative colitis, epilepsy, migraine, uterine myoma, porphyria, systemic lupus erythematosus, herpes gestationis, Sydenham's chorea, haemolytic uremic syndrome, cholestatic jaundice;- In women with hereditary angioedema exogenous estrogens may induce or exacerbate symptoms of angioedema;- Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal.- Chloasma;- Hypersensitivity (including symptoms such as rash, urticaria);
InteractionsBreakthrough bleeding and/or contraceptive failure may result from interactions of other drugs (enzyme inducers) with oral contraceptives (see section 4.5).
Reporting of suspected adverse reactionsReporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via;
United KingdomYellow Card SchemeWebsite: www.mhra.gov.uk/yellowcard
MaltaADR ReportingWebsite: www.medicinesauthority.gov.mt/adrportal
AbsorptionOrally administered dienogest is rapidly and almost completely absorbed. Maximal serum concentrations of 90.5ng/ml are reached at about 1 hour after oral administration of the Qlaira tablet containing 2 mg estradiol valerate + 3 mg dienogest. Bioavailability is about 91 %. The pharmacokinetics of dienogest is dose-proportional within the dose range of 1 8 mg. Concomitant food intake has no clinically relevant effect on the rate and extent of dienogest absorption.
DistributionA relatively high fraction of 10% of circulating dienogest is present in the free form, with approx. 90% being bound non-specifically to albumin. Dienogest does not bind to the specific transport proteins SHBG and CBG. The volume of distribution at steady state (Vd,ss) of dienogest is 46 l after the intravenous administration of 85 µg 3H-dienogest.
BiotransformationDienogest is nearly completely metabolized by the known pathways of steroid metabolism (hydroxylation, conjugation), mainly by CYP3A4. The pharmacologically inactive metabolites are excreted rapidly resulting in dienogest as the major fraction in plasma accounting for approximately 50% of circulating dienogest derived compounds. The total clearance following the intravenous administration of 3H-dienogest was calculated as 5.1 l/h.
EliminationThe plasma half-life of dienogest is approximately 11 hours. Dienogest is extensively metabolized and only 1% of drug is excreted unchanged. The ratio of urinary to fecal excretion is about 3:1 after oral administration of 0.1 mg/kg. Following oral administration, 42% of the dose is eliminated within the first 24 h and 63% within 6 days by renal excretion. A combined 86% of the dose is excreted by urine and feces after 6 days.
Steady-State ConditionsPharmacokinetics of dienogest are not influenced by SHBG levels. Steady state is reached after 3 days of the same dosage of 3 mg dienogest in combination with 2 mg estradiol valerate. Trough, maximum and average dienogest serum concentrations at steady state are 11.8 ng/ml, 82.9 ng/ml and 33.7 ng/ml, respectively. The mean accumulation ratio for AUC (0-24h) was determined to be 1.24.• Estradiol valerate
AbsorptionAfter oral administration estradiol valerate is completely absorbed. Cleavage to estradiol and valeric acid takes place during absorption by the intestinal mucosa or in the course of the first liver passage. This gives rise to estradiol and its metabolites estrone and estriol. Maximal serum estradiol concentrations of 70.6 pg/ml are reached between 1.5 and 12 hours after single ingestion of the tablet containing 3 mg estradiol valerate on Day 1.
BiotransformationThe valeric acid undergoes very fast metabolism. After oral administration approximately 3% of the dose is directly bioavailable as estradiol. Estradiol undergoes an extensive first-pass effect and a considerable part of the dose administered is already metabolized in the gastrointestinal mucosa. Together with the presystemic metabolism in the liver, about 95 % of the orally administered dose becomes metabolized before entering the systemic circulation. The main metabolites are estrone, estrone sulfate and estrone glucuronide.
DistributionIn serum 38 % of estradiol is bound to SHBG, 60 % to albumin and 2-3 % circulate in free form. Estradiol can slightly induce the serum concentrations of SHBG in a dose-dependent manner. On day 21 of the treatment cycle, SHBG was approximately 148% of the baseline, it decreased to about 141% of the baseline by day 28 (end of placebo phase). An apparent volume of distribution of approximately 1.2 l/kg was determined after iv. administration.
EliminationThe plasma half-life of circulating estradiol is about 90 min. After oral administration, however, the situation differs. Because of the large circulating pool of estrogen sulfates and glucuronides, as well as enterohepatic recirculation, the terminal half-life of estradiol after oral administration represents a composite parameter which is dependent on all of these processes and is in the range of about 13-20 h. Estradiol and its metabolites are mainly excreted in urine, with about 10% being excreted in the stool.
Steady-state conditionsPharmacokinetics of estradiol are influenced by SHBG levels. In young women, the measured estradiol plasma levels are a composite of the endogenous estradiol and the estradiol generated from Qlaira. During the treatment phase of 2 mg estradiol valerate + 3 mg dienogest, maximum and average estradiol serum concentrations at steady state are 66.0 pg/ml and 51.6 pg/ml, respectively. Throughout the 28 day cycle, stable minimum estradiol concentrations were maintained and ranged from 28.7 pg/ml to 64.7 pg/ml.
Special PopulationsPharmacokinetics of Qlaira was not investigated in patients with impaired renal or liver function.
|Active film-coated tablets
|Placebo (inactive) film-coated tablet
|Tablet core:
|Lactose monohydrate Maize starch Pregelatinized maize starch Povidone K25 (E1201) Magnesium stearate (E572)
|Lactose monohydrate Maize starch Povidone K25 (E1201) Magnesium stearate (E572)
|Tablet coating:
|Hypromellose type 2910 (E464) Macrogol 6000 Talc (E553b) Titanium dioxide (E171) Iron oxide red (E172) and/or Iron oxide yellow (E172)
|Hypromellose type 2910 (E464) Talc (E553b) Titanium dioxide (E171)
Bayer plc
Bayer House, Strawberry Hill, Newbury, Berkshire, RG14 1JA
+44 (0)1635 563 393
+44 (0)1635 563 000
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text:
Internet Explorer was probably created because Microsoft hates developers, and here is yet another problem to prove it. IE6 and IE7 (thankfully not IE8) have problems when it comes to rendering overlapping absolutely positioned elements. Learn how to fix the bug that causes overlapping with absolutely positioned elements and z-indexes.
Read Fixing Internet Explorer, Absolute Positioning and Z-Indexes


text:
I never get tired of receiving notes from successful athletes. If you need a bit of inspiration, check out the note below.
Before you read, know that I think he's mistaken. I believe it is 60-years young.
From: Iron Bob Sent: Saturday, January 23, 2010 3:23 PM To: Active Trainer Support Subject: event
Gale, Yes we did it!!! Thank you so much. Ironman Florida was great for me! With your help, I have progressed from Olympic distance to Ironman. All four trainings worked well for me.(Olympic, Half-Iron, Beginning Ironman, and 13 weeks to 13 hour Ironman) Next stop is Ironman France June 2010,and yes I will be using your training. 60 years old and ready for an Ironman. Thanks again, Iron Bob
Greetings Iron Bob ~
Thanks so much for dropping me a note. I can't tell you how much it means to me to know my plans help athletes achieve their dreams and goal events.
A huge congratulations to you!
I'm going to post this great note on my blog. (I'll keep your e-mail address off for privacy purposes.)
You are certainly an inspiration to others that might have any hesitations about just going for it.
Keep me posted on how France goes for you.
All the best ~
Gale Bernhardt
Gale Bernhardt
The Coveted Turd Trophy Awards – dried, lacquered and glued
Gale Bernhardt
Will the Federal Grand Jury Information Collected on Lance Armstrong Become Public?
Gale Bernhardt
Myths about coyotes and what you city dwellers ought to know for your own safety and that of your dog
Gale Bernhardt
Can anyone help with some advice for a 44-years-young athlete with a pacemaker?
My dog saved me from an assault
ACTIVE is the leader in online event registrations from 5k running races and marathons to softball leagues and local events. ACTIVE also makes it easy to learn and prepare for all the things you love to do with expert resources, training plans and fitness calculators.


text:
30 October 2010
On the Doorstep
A Bus Tour to the Places of Forced Labor in Berlin
Program surrounding the Special Exhibition "Forced Labor. The Germans, the Forced Laborers, and the War"
30 October 2010, 11 am
3 hours
Meeting Point
Jewish Museum Berlin, Main entrance
12 euros, reduced rate 10 euros
Tel: +49 (0)30 259 93 488
Over half a million people were brought to Berlin to perform forced labor during the course of World War II. They worked for the arms industry and the state railway, for builders, in churches, hospitals, and private homes. The search for traces leads to forgotten camps and factories, but also new signs of remembrance. The tour ends at the Documentation Center on Nazi Forced Labor in Berlin Sch÷neweide, the last preserved camp in Berlin that can be visited.


text:
Assignment: Finding a long-lost parent, sibling
iREPORTS FILED
iREPORTERS SIGNED UP
Created January 27, 2011 by
Oprah Winfrey didn't know she had a half-sister until a few months ago. Winfrey recently revealed that her mother had given the sister, Patricia, up for adoption at birth. Now, the sisters have met each other.
Have you had a similar experience? Is there a sibling or parent you have reconnected with, never knowing of his or her existence?
Update: This assignment is now closed. Thank you for your submissions! You can see some of the best in this CNN.com story.


text:
Client Testimonials
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text: Next → A Voter's Eye View of the 2012 Election - Charles Stewart III ← Previous Miller Center's Balogh Explains Why Obama's Second Inaugural Matters You might also like... Richard Nixon's Greatest Hits (04/21/16) Day 20: "The Need Not to Look Like We're the Ones Who Got Double Violent Right After Christmas" (12/20/15) Day 15: "Will You Be Here for Christmas Day?" (12/15/15) Day 12: "I Know Your Christmas Won't Be What It Ought To Be" (12/12/15) Day 10: "If We Just Had Our Two Boys Back and the Other 555,000 Out There" (12/10/15) Presidential Speech Archive American President: A Reference Resource Presidential Recordings Presidential Oral Histories Comments Rules for Comments We reserve the right to remove any post or user. Things that will get comments edited/deleted: Offensive or abusive language or behavior Misrepresentation (i.e., claiming to be somebody you're not) – using a "handle" is fine as long as it isn't offensive, abusive, or misrepresentative Posting of copyrighted materials Spam, solicitations, or advertisements of any kind We hope these rules will keep the discussion lively and on topic. Commenting is not available in this channel entry. ← Return to Riding The Tiger


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Sound Off: 11/10
Published: Saturday, November 10, 2012 at 3:30 a.m.
Last Modified: Friday, November 9, 2012 at 11:26 p.m.
The University of Alabama should be going green, not Greek. Recent construction on campus looks more like an homage to the lost cause than an embrace of the future. The Romans on their island territories paved flat open spaces to collect water. University parking lots can also be used to collect energy. The university should lead the way in the use and development of solar panels.
— Tuscaloosa
If the University of Alabama is gauche enough to dream up the idea to sell and move the Kilgore House, they should team up with PARA, who came with an equally gauche scheme to build some sort of "restroom pavilion" to complement the ruins at Capitol Park. With the Historical Preservation Commission in charge to ensure a suitable location, the university can donate the house and pay for the move.
— Tuscaloosa
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Halifax Real Estate! Buy or sell a home in Halifax, Dartmouth, Bedford, Sackville & surrounding areas in Nova Scotia with Mariana Cowan of Coldwell Banker SuperMore
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10 - 20EmployeesContact people at this company
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Enterprise_Iteration-NT.1579[01] SEIDXWK-35


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This book is written for the general practitioner; it has some shortcomings and many virtues, the latter being definitely more numerous. The book is addressed to Austro-German physicians, the bulk of whose patients are still treated in their homes even under circumstances that in America are considered to render hospitalization imperative. Part of the book is consequently devoted to detailed instructions on how to administer hydrotherapy and other therapeutic measures in the home. Even this, however, is of benefit to any one not experienced in institutional work. There is also a tendency to deal dogmatically with problems of pathogenesis and etiology. Aside from these rather negligible faults, the book may safely be recommended to any one who desires to orient himself in the field of psychiatry and demands a manual that is neither too technical nor too simple. The chapters on psychopathic personality, epilepsy and alcoholism are especially well done,
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This is a discussion on pxelinux based upgrade of Mandriva 2007.1 - Mandriva ; This is a pretty specialized, but I thought maybe I'd document it in case anybody else ever needed to do it. In our smallish beowulf the 20 compute nodes are running Mandriva 2007.0, and they need to get to 2007.1 ...
This is a pretty specialized, but I thought maybe I'd document it in
case anybody else ever needed to do it. In our smallish beowulf the 20
compute nodes are running Mandriva 2007.0, and they need to get to
2007.1 ASAP because the master node is already there, and there are
backwards compatibility issues with binaries generated on 2007.1 that
need to run on 2007.0. These compute nodes have a floppy (used for
previous initial install on one node) but no CD. On Mandriva 2007.1
there is no floppy boot method for an install, the smallest media the
boot.iso image. Steps 1-4 are all done on the master node. These
normally boot by attempting a PXE load, and if that fails, they boot
from their internal disk. So there was already a dhpcd and
tftp server configured on the master node, and the compute nodes were
set to first try booting MBA. Since all of that was already configured,
it was very easy to add an option to boot the Mandriva 2007.1 installer
- much easier than pulling the node, wiring a CD into it, and then
replacing it.
1. Copy the files to the right place on the master node.
cd /tmp
# obtain the boot.iso, here's one way
wget \
mkdir bootcd
mount -o loop -t iso9660 boot.iso bootcd
cd bootcd/isolinux
cp all.rz /tftpboot/mdv2007_1_all.rdz
cp vmlinuz /tftpboot/mdv2007_1_vmlinuz
cd /tmp
umount bootcd
2. Modify pxelinux so that it knows about these files:
nedit /tftpboot/pxelinux.cfg/default
add these lines
label mdvinstall
KERNEL mdv2007_1_vmlinuz
APPEND initrd=mdv2007_1_all.rdz
and change to this default
DEFAULT mdvinstall
also modify /tftpboot/message.txt to include this new option.
3. modify /etc/dhcpd.conf. This one node was originally
like this (causes it to boot from internal disk):
host monkey01.cluster { hardware ethernet 00:e0:81:22:cc:3d;
fixed-address monkey01.cluster; filename ""; }
change it to this (so it will use pxelinux instead):
host monkey01.cluster { hardware ethernet 00:e0:81:22:cc:3d;
fixed-address monkey01.cluster; filename "/pxelinux.0"; }
Of course, use the appropriate name and MAC for the machine
in question. Then do:
service dhcpd restart
I also restarted xinetd, just for good measure as tftp
runs through that and sometimes after xinetd has been up
for a long time it gets a bit iffy
service xinetd restart
4. Set up routing through the master node so that the compute node
can get to the ftp or http server for its files. I skipped this
part and just unplugged the compute node from the internal network
and plugged it directly into the campus net after step 5. Once the
one node is working it is imaged to the others, so it was easier to
move one plug than to mess about with firewall forwarding rules. On
this cluster normally the compute nodes have no routed access to the
outside world.
5. Plug a monitor, mouse, and keyboard into the compute node,
then reboot it. If everything is set up properly
it will load the Mandriva 2007.1 installer over the network,
and you'll be set to go. In my case, since I skipped step 4,
once the first installer screen came up the network was plugged
into the campus net, and the upgrade carried out.
6. When the installation completes undo the changes to /etc/dhcpd.conf
and restart dhcpd before rebooting the modified node. That way it
will come up in the new OS and not boot the installer again.
I used this method to upgrade from 2007.0 to 2007.1 and it went fine.
The only odd thing, and it had nothing to do with this method, was that
xinetd.d on the cluster wasn't installed quite right, it had most pieces
but not the xinetd binary. A forced reinstall of that one rpm fixed that.
David Mathog


text:
Youngstown, Ohio (AP) -- Though the guest of honor may not attend, organizers say they've sold about 1,000 tickets to a homecoming dinner for an ex-Ohio congressman leaving prison soon.
James Traficant has told friends he wants to keep a low profile following his Sept. 2 release.
But those planning a "Jim Traficant Appreciation Dinner" four days later in the Youngstown area say even if he doesn't show, they hope the event will build his morale.
Democrat Traficant is ending a seven-year federal prison stay for accepting bribes and other corruption charges.
Event organizer Linda Kovachik, a former Traficant aide, says the suggested dress code for the $20-per-plate dinner includes skinny ties, denim suits and bell-bottom pants -- all part of the former congressman's trademark style.
(Copyright 2009 by the Associated Press. All rights reserved.)


text:
On May 20, 6:25*pm, syedahme...@gmail.com wrote:
> Hi All,
> I am trying to find a way to control permissions on the create bug
> form. Basically i don't want all my users to be able to set/edit
> certain fields such as "target", "assigned to" etc in the crete new
> bug form. Ideally i would want a way to assign this restriction on
> certain groups, including the "guest" accounts.
> Is there a way of implementing this?
You can hide those fields, but you may be better off editing the
check_can_change_field method in User.pm, and then updating the bug/
create/create.html.tmpl form.
See the docs for examples: http://www.bugzilla.org/docs/3.2/en/...rmissions.html


text:
|Phone Orders 1-855-Send Pie(736-3743)
Valentine's Day is the day millions around the world profess their love, celebrating their relationship and joy of togetherness through delicious sweets.
It's history is founded on Saint Valentine, a bishop who held secret marriage ceremonies of soldiers in opposition to Claudius II who had prohibited marriage for young men. Claudius believed married men would not make good soldiers due their emotional bonds. When St. Valentine's good deeds were exposed, he was executed on February 14, 270 AD which has now become the date for all lovers.
Show your love with something different this year…a home-made Cookie Pie in 15 different mouth-watering varieties. Each gift-wrapped Cookie Pies comes with your personalized wish delivered in a unique WishBow. Make this a Valentine's Day they'll remember!


text:
Emily Little
A whale of a time
About a month ago, when my mom and I went to Boston for a few days, I was given an amazing opportunity. I was extremely excited when my mom told me that we would be headed to Boston Harbor to hop aboard a whale-watching catamaran operated by the New England Aquarium. We were up bright and early as our boat was supposed to leave the harbor at 9 a.m. We got to the harbor and after a bit of wandering, we found our way to the correct dock. It was about 8:15, and we were the first to arrive. About 45 minutes later, the dock was lined with people who were getting sweaty and impatient. Nearly an hour later, our boat arrived and we all clamored to get into the air-conditioning. Everyone found their seats, and it quickly became clear that the on-boat intercom system was not working. For the entirety of the hour and a half trip out to the "whale zone," the few employees on board attempted to get it up and working. However, their attempts were to no avail, and we ended up having to just listen very carefully when one of the crew was talking. Once we arrived to the area where the whales were usually spotted, we were told it would be a good idea to step outside and walk to the front of the boat. A crewmember stood on a bench and projected her voice as loud as she could, telling us that she would advise us of the whales' location as she would tell us the time on a clock. For example, if a whale were directly in front of the boat, she would yell, "12 o'clock!"Soon enough, the crewmember yelled out, "9 o'clock!" and everyone on board ran to the left side of the boat. A huge humpback whale came up, flipped her tail fluke, and dove down into the ocean. We were told that by looking at the whale's underside, it was possible to identify specifically which whale we had seen. We learned that all the whales in the area were known to the crew. This particular whale's name was Nile, and she popped back up three more times before she disappeared. Sometimes we heard her puff air from her blowhole before we saw her. The crewmember told us that there were three species of whale that we could potentially see, and by the end of the trip, we had seen all three. We saw the humpback, the minke and the finback. It was pretty funny every time the crew yelled out a "clock location" and all the passengers quickly migrated to that area of the boat. It was difficult to manage taking pictures and trying to spot the whales in the distance - I decided to just watch. When I first found out we would be going whale-watching, I thought we would see a few whales, maybe three at most. We ended up seeing seven or eight, with each whale surfacing more than once. On the boat ride back to the harbor we went through all of the pictures we took, and found a particularly candid one my mom captured on her camera. It was a close up picture of a whale's fluke as it went down on a dive, and it was amazing. To say it was an experience I'll never forget is an understatement. It's crazy to think that creatures that weigh almost 75,000 pounds can be so gentle and beautiful. Every single whale was absolutely spectacular, and I would go again in a heartbeat if I had the chance.


text:
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MAR 22, 2014 - Cleveland Plain Dealer
A Must Read - Share
One of the most over-hyped events for college quarterbacks are the Pro Days.
GOODYEAR, Ariz. -- Lots of notes on all three teams as I watch the Tribe in spring training: About one QB's "poor" Pro Day ... So Teddy Bridgewater had a bad Pro Day. I really don't care. Yes, a quarterback should look good when he's throwing to familiar receivers on his home turf. But to draw any major significance from this is silly. JaMarcus Russell, Blaine Gabbert, Brady Quinn and Geno Smith are just some college quarterbacks who had great Pro Days. It's sort of like grading a
Read More
Editor's Picks
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text:
The unbeaten Ferris State University football team will host a second-straight NCAA Division II Playoff game as the Bulldogs entertain archrival Grand Valley State in the second round this Saturday, Nov. 28, at FSU's Top Taggart Field in Big Rapids. Kickoff is set for 12 p.m. (ET).
The Bulldogs are 11-0 overall and capped off a second-straight unbeaten regular season along with winning a second consecutive Great Lakes Intercollegiate Athletic Conference (GLIAC) Championship this year. Meanwhile, the Lakers hold a 10-2 overall mark and compiled an 8-2 league mark in the GLIAC this season.
Ferris State is the number two seed in Super Region Four with GVSU seeded sixth. It will mark the first-ever postseason matchup between the two West Michigan rivals on Saturday.
Tickets for Saturday's playoff game are currently on sale and fans are encouraged to purchase tickets in advance. Ticket prices are $10 for adults, $7 for senior citizens (age 65+) along with $5 for students in grades K-12. In addition, students from both competing institutions with a valid ID card are also $5. Children ages five and under are free.
Per NCAA policy, all fans will need a game ticket to enter the stadium and no season passes, conference passes or the "Division 2 Pass for Two" will be accepted for playoff contests.
Fans fan purchase tickets online 24 hours a day, seven days a week at StarTickets.com or call (800) 585-3737. Tickets may also be purchased in person thru the FSU Athletics Ticket Office inside the Ewigleben Sports Complex. The ticket office will be closed on Thursday due to the Thanksgiving holiday, but open from 9 a.m. to 5 p.m. on Friday. The gameday ticket office at the Wheeler Pavilion at Top Taggart Field opens Saturday at 10 a.m.
Saturday's playoff game will be carried live locally by the Bulldog Sports Network and Sunny 97.3 FM with the veteran broadcast team of Rob Bentley (play-by-play) and Sandy Gholston (color) calling the action. Pregame coverage begins at 11:30 a.m. (ET). The contest will also be streamed with a free live audio and video feed online at FerrisStateBulldogs.com in conjunction with Ferris State Television. FSU will also provide live internet statistics.
In addition to radio and internet coverage, Bulldog fans can also follow Saturday's contest with live scoring updates on several official social media platforms. Visit www.twitter.com/FerrisFootball to follow the tweet-by-tweet coverage with periodic scoring updates or visit www.facebook.com/FerrisFootball.
Below are some important Gameday Details:
* The Wheeler Pavilion Gameday Ticket Office will open at 10 a.m. on Saturday
* Tailgating will be permitted starting at 9 a.m.
* Gates to the stadium open at 10:30 a.m. (90 minutes before kickoff)
* The Bulldog Player Parade - will take place at 9:30 a.m.
* Credit cards will be accepted at the stadium ticket office & concession stand
* Concession stand will provide wide assortment of food & drinks
* Parking is $5 per available space, including Lot 2 on campus
* Gridiron Club members should enter off South Street in Lot 35
* Lot 2 is designated for Grand Valley State fan tailgating
* Grunst Party Store is the official sponsor of the Game Day Page. Head to Grunst Party Store for all your tailgating needs
* Click Here For Gameday Parking Map (PDF)
Please visit the respective links below for additional gameday information:
Team Video Center
Gameday Central
NCAA Division II Football Playoff Game
Ferris State vs. Grand Valley State
Saturday, Nov. 28, 2015
Top Taggart Field
Big Rapids, Mich.
Kickoff: 12 p.m. (ET)
Media Information:
Radio Broadcast: Bulldog Sports Network & Sunny 97.3 FM (Pregame coverage @ 11:30 a.m.)
Radio Announcers: Rob Bentley (Play-by-Play), Sandy Gholston (Color)
Bulldog Sports Network Audio-Only Webcast: Click Here
Live Video Webcast (FREE): Click Here
Live Internet Stats: Live Stats
Live Twitter Scoring Updates: Click Here
Live Twitter Analysis Updates: Click Here
Live GLIAC Scoreboard: Click Here
General Information:
Tickets: Click Here for more info
Directions: Click Here For Directions
Weather: Click Here For Big Rapids Weather
Stadium Information:
Top Taggart Field
Ferris State Game Notes
Ferris State Roster
Ferris State Schedule/Results
Ferris State Statistics
Ferris State Coaching Staff
Ferris State Yearbook
Ferris State Football News
Ferris State Football Website
GLIAC Football Website
GVSU Roster
GVSU Schedule/Results
GVSU Statistics
GVSU Coaching Staff
GVSU Football News
GVSU Football Website


text:
It has been a while since I reached into the mailbag, and since it is too cold out to do anything outside in Montreal today I thought I'd take some time to answer some of your questions.
First though, the Lightning held an uneventful optional skate at the Bell Centre this morning in Montreal, and the two-block walk to and from the rink was downright painful. The snow banks in Montreal are about four feet high right now, and my Men's Wearhouse dress shoes weren't made for this weather! Also, the dinner last night at Gibby's in Old Montreal was fantastic as usual. If you're ever in town, you've got to check it out.
Now to your questions….
Melody asks:
Can you please tell me what happened to Michel Ouellet and why he is on the injured reserve list?
Hey Melody. Ouellet was injured on December 13 against Calgary at the St. Pete Times Forum. He separated his shoulder when he was checked into the boards. It was fairly obvious when it happened that he was hurt by the check as he skated away favoring his shoulder and went directly to the bench and didn't return. At the time of the injury the Lightning said he was expected to be out 4-6 weeks. That puts him at about 1-3 weeks now. He is on the road with the team but has yet to start skating again.
Pete and others have asked:
Will Boyle be back for the regular season at all?
I continue to get a number of questions regarding Dan Boyle's progress and when the team expects him to return. While the team has not put a time table on his return, Boyle has begun skating on his own and has started doing some stick-handling work. He is with the team on the current road trip as he continues to work his way back into the lineup. There is no reason he shouldn't be back by the end of the season. Boyle saw the doctor that performed the surgery in Baltimore when the team traveled to Washington for the game on December 26 and he cleared Boyle to begin skating and reported that everything was healing fine.
Kirk wonders:
What happened to the goal judges this year and who turns on the red light when a goal is scored?
The off-ice goal judge was moved to the accessible sections behind the goals in the St. Pete Times Forum. It is different in each NHL Arena. Relocating the goal judge makes it easier for fans in the area behind the nets to follow the play. Previously, fans in the end zone would have to look around a big plastic box with the official in it. With all teams using video replay now it is less important to have that goal judge so close to the action.
David Pacht asks:
I'm a big fan of Adam Henrich. I have followed him since his days in the OHL. We all know about how he didn't get picked up at the end of his three-year contract, but he had an amazing start first in the ECHL with 20 points in 12 games and now finally with 11 points in his first six games (in Norfolk of the AHL)! Tampa Bay obviously gave him a second shot for a reason do you think if he keeps up his play he has a chance of getting called up to the big club?
Hey David, you might be the most knowledgeable person about Adam Henrich I've seen! Yes, Henrich has really turned things around this season. He has played in only 15 of the Admirals' 35 games this season and is third on the team in goals with eight while also being tied for fourth in points with 15. He has excelled on the power play as half of his goals have come with the man advantage. He certainly earned his tryout agreement with Norfolk and earned the right to stay. It's probably a little early to say that he is going to be called up, but never say never. Based on Tampa Bay's meritocracy system, if he keeps it up there is no reason to rule it out if a forward is needed. He just needs to keep showing that he deserves it more than anyone else, and the Lightning would need to sign him to an NHL contract (his deal is currently AHL only).
Liz Boltd ponders:
I have two questions that maybe you could answer. 1. Do you know where the post-game practice of bumping helmets in celebration/acknowledgement came from? 2. How do the Lightning keep track of the time that the players are on the ice? Does each player have someone assigned to monitor their individual time with a stopwatch, or is it more mechanized like a timing device on a players skate? Thanks for the time, and I am really enjoying your column.
Hello Liz. I did some research and asked around and didn't find anything concrete on where the helmet-bumping came from. By most players' and staffers' estimation it is something that started in the past 15 years. There has always been the congratulating of the goaltender after the game, but not always a specific head butt. Most thought it probably came from other sports in which players bang heads, like football.
As for the other part of your question, player ice time is monitored and tracked by the NHL's off-ice officials in the press box. In their booth in the press box they use the NHL HITS system to provide player ice times. Multiple officials are assigned to keep tabs on player ice time.
… and finally the question of the day …
Amongst other things, Hockey Chic asks:
Love your report; when can we expect to learn your identity, eh? I am thinking tall, grey and handsome maybe. Just a guess; Capt Dave or Chief?
Thanks Hockey Chic; glad you like the updates. You're just going to have to figure that one out on your own; I'm not going to spill the beans. I like my anonymity and don't want the paparazzi following me around!!!


text:
Welcome to Mr. Phillips' page! In addition to direct contact with teachers, CSD is pleased to provide more granular access to specific notes from teacher classrooms. With this increased access to teacher updates published on the website comes a wide array of subscription options. Using the links provided on the Connect page, classroom families can easily define what information (news and/or teacher notes) they wish to receive, as well as how they receive this information; delivery options for each category of news and/or teacher notes includes email, text message (SMS), Twitter and RSS.
Mr. Phillips
CAPS Intermediate Guide to Lewis and Clark & The Oregon Trail
The 2014-2015 school year has been extremely exciting so far as we have been taking a trip through our early nation's history. After spending time in class talking about Thomas Jefferson and the Louisiana Purchase, we followed the steps of… [Read More…]
1st Thursday Popcorn Musical Experience at Springdale CAPS
1st Thursday Popcorn – A Springdale CAPS Youth Arts Musical Experience The first Thursday of each month Springdale CAPS will host a night of musical performances from 6:30-8pm (There may be times that the event does not run… [Read More…]
1st Thursday Popcorn at Springdale CAPS
1st Thursday Popcorn – A Springdale CAPS Youth Arts Musical Experience The first Thursday of each month Springdale CAPS will host a night of musical performances from 6:30-8pm (There may be times that the event does… [Read More…]
Impressionism, Space Science and Birdhouses! Oh My!
I wanted to share some pictures of a few things we have been working on over the past month or so. Our theme for the year has been patterns and one of our artistic focuses has been on impressionism. We… [Read More…]
Springdale CAPS : The Autumn Chronicles
As I sit here and look back to the beginning of the school year I wonder where all the time has gone. I can still remember feeling so excited to see all of the students back at school and looking… [Read More…]
Hello parents and friends, If you have any questions about our class or want to stay up to date with Mr. Phillips' Intermediate class please go to our class website. You can find information about me, my teaching tenets, rules,… [Read More…]
Family Dance Night Reminder!
I just wanted to post a quick reminder about the Family Dance Night in the Sprindale gym tonight. There will be some extremely talented students sitting in with a band that I am bringing to the dance party. We… [Read More…]
Springdale School Scholastic Book Fair 12/10-12/13
This week we are kicking off our Scholastic Book Fair. I wanted to make sure to pass on all the information I have about the book fair. We will be going in as a class to have a look around on Monday 12/10 and then go back to make purchases on Tuesday and Wednesday. Fair … Keep reading → Continue reading
Wednesday, December 12th – Springdale Expo
Hello everyone! Coming up this week on Wednesday, December 12th we are having a Springdale Expo! The primary and intermediate students have all been working hard to bring some holiday cheer to you as they show some of what they have been learning in music class. Each class will have some special music presentations, as … Keep reading → Continue reading
Christopher Phillips – Educator/Musician 2012-12-01 16:45:10
Hello students and parents- I know homework assignments and even just general knowledge of what is going on in the classroom can get lost in translation between school and home so I created a homework page to help with communication. I apologize this has not happened sooner but now that the … Keep reading → Continue reading


text:
MAY 01, 2013 - Health Canal
A Must Read - Share
Research by Allegheny General Hospital Allergists Published Today in Journal of Allergy and Clinical Immunology Predicts Improvements in Diagnosis and Treatment of Common Childhood Problem
Editor's Picks
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© 2011 Comunitee, Inc.


text:
Mac OSX 10.7.2 support?Posted Sunday, 1 January, 2012 - 14:42 by tksuoran
|The Open Toolkit library
|bug report
Jump to:
I have some trouble getting RenderStack running properly on Mac OSX 10.7.2.
First, I can't seem to be able to create OpenGL 3.2 core context.
Second, input does not seem to work.
Has anyone succeeded with 3.2 core context?
Is the current mac platform code in OpenTK even able to do it?
I see current core uses AGL and Carbon, while I am suspecting that for GL 3.2 support might require using Cocoa and NSOpenGLView.
I see that OpenTK only has PixelFormatAttributes up to 61 (kCGLPFASampleAlpha). In order to create 3.2 profile context, one would need to specify kCGLPFAOpenGLProfile -> kCGLOGLPVersion_3_2_Core. That is clearly is not supported by current Mac platform code in OpenTK :/
I request an OpenGL 2.1 context during initialisation of my OpenTK app and can render just fine (http://blog.nycterent.com/macosx-compatibility) but have not tried creating an OpenGL 3.2 core context specifically.
Input, however, is a whole other matter. I posted about what I encountered here: http://www.opentk.com/node/2800 which contains details about what I discovered.
I'm really hoping someone has an answer, Mac support is high on my list of priorities.
I sat down and decided to test the input issue more completely tonight and discovered that input does work, so long as you don't use the Keyboard.GetState() method since the HIDInput integration is broken in OpenTK on OSX 10.7. However, It processes window events just fine and at the moment, OpenTK jams the key events into the dummy devices it has inside OpenTK.Platform.MacOS.CarbonInput which are accessible inside GameWindow via InputDriver.Keyboard[0] and InputDriver.Mouse[0] (there is always 1 mouse and 1 keyboard, they're setup in the constructor of CarbonInput, so it's safe to use [0] even though normally it would be very bad).
I've moved my input routines across to using InputDriver.Keyboard and InputDriver.Mouse and it's working just fine on Windows and Mac, and will be sufficient until the problem can be resolved properly (I prefer the Keyboard.GetState() approach personally) because GameWindow.InputDriver has been marked as Obsolete.
Hope this helps someone.
|» critical
Creating GL 3.2 context remains not possible.
|» 1.1-2014-01-02
|» closed
It is not possible to create a 3.2 context using Carbon/AGL. Thank Apple for that. :)
OpenTK 1.1 beta1+ provides a SDL2 backend that supports OpenGL 3.2. A hypothetical Cocoa/NSOpenGL backend would also solve this if it were ever implemented.