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XML ancillary files
From ArachneWiki
The XML ancillary files are located at DATA/traceinfo/*xml*. They contain ancillary data about the reads; each read gets its own entry in one of the files. This ancillary data may be modified and supplemented with the aid of the configuration file.
The XML ancillary files are in the Trace Archive XML format (http://www.ncbi.nlm.nih.gov/Traces/trace.cgi?cmd=show&f=rfc) and are parsed by the module TraceArchiveParser. We use only a subset of the fields specified in the Trace Archive XML definition. Note that all field names are case-insensitive. The following fields are required for each read entry (or may be, depending on the read type):
- trace_name: The name of the read, which should be unique.
- plate_id: The name of the plate on which the read resides. For paired production reads, it is normal practice to designate the same plate_id for two physical plates, one having the forward reads and the other having the reverse reads.
- well_id: The well on the plate that the read came from.
- type: "paired_production", "unpaired_production", or "transposon". Note that this field is not part of the Trace Archive Format and therefore must be set using the configuration file.
- template_id: The name of the template (insert). Arachne identifies forward-reverse read pairs as those sharing the same template_id. Required for reads designated "paired production" or "transposon". The concept of a template for a transposon here is simply a kludge to associate a pair of transposon reads from the same transposon event, so there should be a different template id for each transposon event.
- clip_vector_left: The position at the beginning of the read sequence at which it should be clipped due to vector sequence (i.e. the index of the first base of non-vector sequence).
- clip_vector_right: The position at the end of the read sequence at which it should be clipped due to vector sequence (i.e. the index of the last base of non-vector sequence).
- insert_size: The estimated insert size, in bases, for paired production reads. The estimated separation, in bases, for transposon reads. Required to be non-zero for reads designated as "paired production" or "transposon" (see the type field below).
- insert_stdev: The standard deviation of the insert size, in bases, for paired production reads. The standard deviation of the separation, in bases, for transposon reads. Required to be non-zero for reads designated "paired production" or "transposon".
- trace_end: The direction of the read on its insert (either F for forward or R for reverse). Required for reads designated "paired production" or "transposon".
The following fields are optional:
- center_name: The research center from which the read came.
- library_id or seq_lib_id: The name of the library containing the read. Optional, but highly recommended.
- ti: The trace archive number.
<trace> <trace_name>L3191P13FA1.T0</trace_name> <plate_id>L3191P13</plate_id> <well_id>A01</well_id> <template_id>L3191P13A1</template_id> <trace_end>F</trace_end> <clip_vector_left>39</clip_vector_left> <clip_vector_right>801</clip_vector_right> <library_id>L3191M1</library_id> <insert_size>1500</insert_size> <insert_stdev>225</insert_stdev> </trace>


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Should Human and Veterinary Medicine Be Combined Into One Field of Study?
The fictional Ace Ventura may be tops when it comes to pet detectives, but the real animal gumshoes may be of the nonhuman sort — at least when it comes to environmental issues. More and more, we are recognizing the incredible powers of observation and deduction our fellow creatures possess, and we are using them to help us uncover the "bad guys" in our air, homes and workplaces.

subset: commoncrawl


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The Stroller: 'Wonder why'
Published: Tuesday, February 12, 2013 at 3:15 a.m.
Last Modified: Monday, February 11, 2013 at 4:27 p.m.
Dave West of Moore says tongue-in-cheek he is looking forward to the day when his son has a job with benefits such as those given our president. "Benefits like a good salary, full-time employment with lifetime benefits and access to transportation like Air Force One to go anywhere he desires," mentions Mr. West. "Given this example, my son should be able to use the company car and spend all the time necessary traveling all over the country to tell other employees what a wonderful job he is doing and make plans for his continued employment for years to come. Makes you wonder why any employer would pay for this. Only in America."
'HAS TO STOP': "Answer the phone," Laura McLeod of Spartanburg tells folks at the post office in Spartanburg. "If not, I'll have to find someone to give me a ride down there to get to the bottom of why my mail continues to be lost or destroyed. I have mailed letters with money orders and checks, and they simply disappear, never reaching the person I mailed them to. That has to stop, and they must answer the phone."
'ABOVE AND BEYOND': Jean S. Coley of Spartanburg is singing the praises of doctors and staff who cared for her during her stay in Mary Black Memorial Hospital. "Throughout my two days in intensive care and two days on the fourth floor, I was taken care of by some of the most compassionate, capable people I have ever met," she says. "My three doctors, Joseph Beets, Thomas McLeod and Jeffrey Jarin, diagnosed my problem quickly, acted with skill and competence and gave me great follow-up care. All of the medical staff and hospital employees went above and beyond to ensure that I was comfortable and taken care of. My family and I will be eternally grateful for the excellent medical care I received in Mary Black Memorial Hospital."
ON THE ROAD: There's still time to sign up for the next On The Road With The Stroller trip to historic Savannah, Ga., plus a tour of the S.C. Statehouse and some delicious Southern fare promising no one will go hungry. You can get a reservation form either at the Herald-Journal or by calling our travel agent at 336-794-3233. Reservations for the April 28-30 trip are being accepted on a first-come, first-served basis.
LOST IN TRANSLATION: Ben Cromer of Inman says a text from the wife on a cold winter morning read, "Windows frozen. Won't open." The husband sent a text back that read, "Gently pour some lukewarm water over it." The wife sent a text five minutes later that read, "Computer really screwed up now."
ODDS AND ENDS: It is that season, and The Palmetto Statesmen is offering singing Valentines. The group will send a barbershop quartet to the location of your Valentine, whether that is an office, restaurant, home, retirement center or hospital, or wherever they are allowed. The quartet will be in tuxedos and will sing two love songs in barbershop harmony and also present the Valentine with a card and a rose, all in your name. Five quartets are ready to go and will be delivering Wednesday and Thursday. To place an order, call 576-3734. The cost is $45.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on CafePress-Custom T-Shirts, Unique Gifts, Posters and more. at the time of purchase will apply to the purchase of this product.
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© Copyright 2016 - Christmas.com. All rights reserved and protected by Christmas Spirit


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You try to keep up with work, but the emails keep flooding in all day long.
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You try to keep up with work, but the emails keep flooding in all day long.
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Wednesday, February 19, 6pm
FREE to the general public
This program features a world premiere by Val Caniparoli. Dance educator Mary Wood interviews Mr. Caniparoli, who will provide insight into his creative process that has made him a world-renowned choreographer with works in the repertoire of over 40 companies.
See all Pointes of View Lecture events.
Tuesday, February 18, 7pm
Friday, February 21, 7pm
Sunday, February 23, 1pm
Orchestra Level of the War Memorial Opera House
Open to ticket holders of that afternoon/evening's performance
A highly popular pre-performance discussion program, Meet the Artist Interviews (MTAs) spotlight the specific San Francisco Ballet repertory program to be performed that afternoon/evening.
See all Meet the Artist Interview events.


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This week, "Dancing With the Stars" had a new theme, a new guest judge and, alas, a new elimination for the remaining seven couples. Week 7 was Latin Night with all the fancy footwork that the celebs and pros could muster, and Ricky Martin kicked off the evening by leading a hip-shaking, shoulder-shimmying opening number before heading to the judges' table.
Speaking of which, the guest judges have usually been seated between head judge Len Goodman and judge Bruno Tonioli. But that was before Week 5 when Donny Osmond joined the judging panel. It seemed that during his moments addressing the dancers, Bruno couldn't keep his hands off Donny, clutching his hand, stoking his arm. To Donny's credit, he always laughed it off and treated it as a joke. However, since that week, the guest judge now sits between judge Carrie Ann Inaba and Len. I wonder who was feeling more uncomfortable -- Donny, viewers or the producers?
Anyway, back to Week 7 -- if Latin Night wasn't enough to get your toes tapping in anticipation, it was a Team Dance week with both teams doing a "freestyle" routine to a Ricky Martin tune in addition to each couple's individual dance. On Team Loca, dancing to "Livin' La Vida Loca," were Meryl & Maks, Amy & Derek, Danica & Val, and Candace & Mark. Dancing to "Cup of Life," was Team Vida: Charlie & Sharna, James & Peta, and NeNe & Tony. At first glance, it seemed that Team Loca had an advantage, both in numbers of couples and in higher-scoring pairs, but who knew that one of the team would be missing in action.
Right off the bat, before a single toe touched the dance floor, results were announced. Danica McKeller and Val Chmerkovskiy, and Amy Purdy and Derek Hough were declared safe to dance next week, but James Maslow and Peta Murgatroyd were in jeopardy. How awful for them to wait through the whole program to find out if they were off the show, and I think the start of the show is a bit early to be announcing results.
Later in the show, NeNe Leakes and Tony Dovolani, and Charlie White and Sharna Burgess were also said to be in jeopardy. When the final results were announced, NeNe and Tony were eliminated. When asked by Erin of what she was most proud, NeNe said, "I'm so proud of myself and I hope that I have inspired women all over the world. This has been an amazing, positive experience for me."
After thanking her husband, children, family, friends and even the judges for their support, she said, "I am proud of NeNe Leakes!" She also thanked Tony with whom she has a "great connection." In turn, Tony said he made a friend and they had made it through some problems and "came out on top."
Amy and Derek were the first couple to dance tonight, but rehearsal footage showed that it wasn't shaping up as a walk in the park. They were dancing a rumba, a very, very sexy dance, but we found out that Amy has been having problems at home with the demands of her schedule conflicting with the challenges of a long-term relationship. With the help of Derek, she fought her way through it to perform a sensuous rumba that Len said was "first class." While Carrie Ann took off points when Amy's foot left the floor, Ricky described the dance as "stunning." Scores: Carrie Ann, 9; Ricky, 9; Len, 9; Bruno, 9 = 36
After the scores were announced, unfortunately, Amy said that she turned her head and felt something "pop." She had back spasms and was having a difficult time breathing, so she was sent to the hospital. As a result, Team Loca would be judged on its performance during dress rehearsal, and it was unknown if Amy would be able to continue in the competition.
Coming close to a perfect night, Meryl Davis and Maks Chmerkovskiy continued to roll with incredible dances. Although Len called their salsa "a bit hectic," it was an amazing routine, filled with fast footwork and complicated tricks. To me, it looked like Meryl was one of the pros dancing in the number. "You continue to surprise me," said Carrie Ann. Bruno added, "You were dancing in front of six of the best pros in the country and you pulled the focus." Scores: 10; 10; 9; 10 = 39
Week after week, Candace Cameron-Bure has had trouble with her nerves causing problems so pro partner Mark Ballas took her to see a sports psychologist for help. The doctor's advice must have worked because she danced her best routine, a smoldering Argentine tango that pulled high scores and compliments from the judges. Scores: 8; 9; 9; 9 = 35
It seems like the time in the competition for injuries to mount, and this week, Danica McKeller fractured a rib during rehearsal. However, she performed a salsa that partner Val Chmerkovskiy toned down a bit. Carrie Ann said she noticed that Danica's injury "stifled the dance" and Ricky praised her for "sticking with it." Scores: 8; 9; 8; 8 =33
James and Peta performed a sexy samba, and up in the skybox after they danced, co-host Erin Andrews pegged it right: "James, you take your shirt off and you (turning to Peta) come out as a Victoria's Secret ad." Peta costume was so scanty, the staff couldn't find a place to put a mic! Bruno said it was "filthy, dirty, and I loved it." However, Len said that he would have liked to see more hip action. Scores: 9; 9; 8; 9 = 35
No matter how hard pro Sharna Burgess tries to turn Charlie White into a bad boy or menacing villain, Charlie still looks like the cute boy next door. And it happened again tonight with their paso doble. Even stripping off his jacket didn't help and Len even asked if it was "take off your shirt night." However, when Len said, "To get a 10, it must be special and this wasn't special," it seemed to get Charlie a bit upset. Scores: 9; 10; 8; 9 = 36
Then it was team dancing time. Team Vida, a vision in turquoise, performed their freestyle that Len called "tight" and "well done." Scores: 8; 10; 8; 9 = 35, which was added to each couple's individual score. The judges watched a tape of Team Loca's dress rehearsal, but to their credit, the remaining members of Team Loca danced the routine for the audience with Derek dancing to an invisible partner. Len thought it was fantastic and Bruno called it "a show-stopper." Scores: 10; 10; 9; 10 = 39, added to each couple.
In the end, Meryl and Maks topped the leaderboard with a score of 78 out of 80, while James and Peta are at the bottom with 70 out of 80, and Charlie and Sharna are just one point ahead of them. As a result, it looks like a good dancer will be heading home next week. Until then, keep dancing.


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- Sep 3:
- Los Gatos football: New coach, veteran talent this fall
- Sep 2:
- Mitty football: Defense is the key for Monarchs in the tough WCAL race
- Valley Christian football: Led by its star tailback, the sky is the limit
- Bellarmine football: New group of Bells ready to make a run at another WCAL title
- Westmont football: Goal is the same as always for Warriors--compete for league title
- Santa Clara Valley is--and has always been--a hotbed for QBs
- St. Francis football: Familiar name back as Calcagno steps in as head coach
- Harker football: Veteran receivers, a young QB keys to the season
- Saratoga football: Division's 'big 4'? Lugo thinks it's the 'big 5'
- Monta Vista football: Matadors may be small in numbers and size, but big on talent
- King's Academy football: Talented junior class the key for Knights' in their bid to rebound
- Cattolico leaves a legacy on the football field, and on report cards
- High school football preview: Players to watch
This time last year Prospect High's football team was revving up a run-oriented offense. The Panthers spent much of their preseason drills meshing the skills of an experienced offensive line with the speed and strength of promising sophomore quarterback Raiden Sainz.
And the Panthers started 2012 in high gear. A threat each time he touched the football, Sainz ran for 242 yards and one touchdown in the season opener against Fremont of Oakland. And the 5-foot-8 dynamo kept it going the next week at Fremont in Sunnyvale, rushing for 122 yards and two more scores in just the first half.
Unfortunately, midway through that game, Sainz suffered a severe ankle injury, forcing coach Mike Suarez to go to Plan B.
Fortunately, Prospect had 6-foot-1 junior Angel Guillen on their side. The frosh-soph's starting QB the year before, Guillen came off the bench to finish the game, completing 8 of 14 passes for 88 yards and a touchdown.
That was just the beginning. After a tough go against Westmont in his first varsity start, Guillen improved each week. By season's end, Guillen had attained all-league status, completing 53 percent of his passes (111 for 210) for 1,590 yards and 14 touchdowns. He also ran for two other TDs.
"Angel really capitalized on that opportunity," Suarez recalled, "and we slowly transitioned from being a running team to being a passing team."
Guillen's best yardage totals came in three straight games late in the Blossom Valley Athletic League West Valley Division season. He passed for 241 yards against Andrew Hill and followed that with 353 yards and two TDs against San Jose on 58 percent accuracy (29 for 50). He repeated the 300-plus effort at Evergreen Valley, connecting on 21 of 34 (61 percent) for 309 yards and two more scores.
Sainz came back for four games late in the season and "made an impact as a linebacker on defense," Suarez said, while Guillen maintained the quarterback position and earned first team all-league recognition.
"He forced us to change our offensive thinking, and we will rely on his decision-making abilities this season," said Suarez about Guillen, who has grown to 6-foot-3 and 170 pounds. "We're looking for Angel to mix it up, finding opportunities to stretch the field a bit and to get the ball out to receivers in space."
Guillen sharpened his skills at the David Shaw Stanford Football Camp during the off season, along with his three favorite pass receivers from 2012: seniors Daniel Newson (5-foot-9, 150), Christian Nielsen (6-foot-1, 205) and Kevin Moon (5-foot-8, 155).
Newson, a wideout, ranked eighth in the CCS in receptions (49) and 15th in receiving yards (722) and eight of his grabs went for touchdowns. Tight end Nielsen (23 catches, 351 yards, 4 TDs) and running back Moon (21, 210, 1) were second team all-leaguers.
Moon's 96 carries, 446 yards and six TDs paced the Panthers' ground attack in 2012.
Suarez believes the trio will be even more productive in 2013.
"With those three guys back, Angel has the tools to be successful," Suarez said. "We're looking forward to more production from each of them."
Blocking up front will be led by big senior Diego Posada (6-foot-7, 305), who moves over to left tackle from right tackle.
"He is our most physically imposing athlete on the team," Suarez said. "We will look to him to lead us on both lines."
Another returning starter along the offensive line will be senior Brandon Chavez (5-foot-9, 190), who will take over the center spot. Joining them in the starting line-up will be three players up from the frosh-soph, juniors Fernando Ceja (5-foot-9, 200) and Jesus Fierro at the guard positions and sophomore Justin Lynn (6-foot-1, 230) at right tackle.
"We hope they can adjust quickly to the speed of the varsity game," Suarez said. "Ceja and Fierro were the captains and Lynn was the team's MVP."
In addition to providing pass protection for Guillen, the line will be relied upon to create running room for Moon, who will be a two-way starter for the Panthers at running back and free safety.
"He is an all-around offensive weapon and a true game-changer on defense," Suarez said about the speedy Moon, who led the team with 790 all-purpose yards and tied Newson for the most TDs (8).
The Panthers will miss the running of Justin Elmensdorp, who transferred to Westmont after packing the ball 56 times for 265 yards last fall as a junior, but Suarez anticipates contributions from a pair of newcomers, senior wide receiver Jeremy Kaewkan (5-foot-9, 180) and junior running back Chance Sparkman (5-foot-9, 150). Kaewkan, a frosh-soph standout for two seasons, returns to the gridiron after not playing as a junior and Sparkman moved up from the frosh-soph.
On the defensive side of the ball, Suarez expects Nielsen to again be one of the leaders from his inside linebacker position. Nielsen, who ranked second on the team last fall with 74 tackles (11 for losses), will be joined in the middle by sophomore Sam Adams, who was promoted from the frosh-soph.
Other top defenders returning for the Panthers include senior linebacker Sam Palermo (5-foot-9, 150), who made 28 tackles, and defensive backs Newson (29) and Moon (26) and Posada on the line (24).
Returning senior Angelo Patti (5-foot-9, 170), Lynn, Fierro, Ceja, Chavez, Kaewkan and Sparkman all could be factors for the defense, which will be directed again by defensive coordinator Rudy Suez.
"Experience among the starters and team speed will be our strengths," said Suarez, who also will be assisted by Byron Burnett, Adrian Wise and Fernando Suarez.
"Our lack of depth could be a factor," admitted Suarez, noting the transfers of three players and eligibility issues of others.
Sainz, who made 29 tackles, including six for losses, and averaged more than 11 yards per carry in his six games last fall, and two-way senior lineman Robell Yosief (6-foot-3, 270) are among a handful of Panthers ineligible for the first several games. Their return should improve the team depth, Suarez said.
Prospect, which finished fifth in the eight-team West Valley Division with a 3-4 record and went 3-7 overall, will have five new opponents this season. Cupertino, Lynbrook and Gunn, all are from the El Camino Division of the Santa Clara Valley Athletic League, will comprise the non-league schedule. Branham and Mount Pleasant will be new division rivals, dropped down from the Santa Teresa circuit and switching places with 2012 West Valley champion San Jose and third-place Evergreen Valley.
After opening on the road at Cupertino on Sept. 6, the Panthers will have a bye week before hosting Lynbrook on Sept. 20. They will travel to Palo Alto Sept. 27 to tangle with Gunn in their final tune-up before hosting Del Mar in the West Valley opener on Oct. 4.
Key Players
Kevin Moon (5-7, 155), Sr., RB/FS
Angel Guillen (6-3, 170), Sr., QB
Diego Posada (6-7, 305), Sr., OL/DL
Christian Nielsen (6-1, 205), Sr., TE/LB
Daniel Newson (5-9, 150), Sr., WR/DB
Brandon Chavez (5-9, 190), Sr., C/DL
Sam Palermo (5-9, 150), Sr., RB/LB
Sept. 6, at Cupertino, 7:30 p.m.
Sept. 20, Lynbrook, 7 p.m.
Sept. 27, at Gunn, 7:30 p.m.
Oct. 4, Del Mar, 7 p.m.*
Oct. 11, at Yerba Buena, 7 p.m.*
Oct. 18, at Overfelt, 7 p.m.*
Oct. 25, James Lick, 7 p.m.*
Nov. 1, at Hill, 7 p.m.*
Nov. 8, Mt. Pleasant, 7 p.m.*
Nov. 15, Branham, 7 p.m.*
* Denotes BVAL West Valley Division game


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The annual Christmas Tour of Homes will be from 2 to 4 p.m. Saturday.
Attendees will have the opportunity to dive into the holiday spirit by viewing the interior and exterior decorations of four area residences.
Tickets are $15 per person purchased before Saturday, or $25 purchased on Saturday. All sales support the operations of the McPherson Museum and Arts Foundation. Tickets may be obtained by calling 620-241-8464.
Location, ST | website.com


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CORPUS CHRISTI – Junior Vanessa Johnson set a new school record with a 67 in the second round of the 36th Annual FIU Pat Bradley Invitational on Monday. Johnson's was the low round of the day in the field, and she now sits eighth overall through the first two rounds of the Invitational.
Johnson shot 34 on the front and 33 on the back in the second round. She is now three shots off the individual lead, held by So Young Hwang (Daytona State) and Taylor Gohn (Missouri) who are both 4-under-par at 140 through two rounds. Johnson is tied for eighth with a 143 through the first 36 holes.
"What a round for Vanessa," head coach Carol Blackmar said. "She's always been a great golfer for us, but for her to break the school record by two strokes and have the low round of the day at this prestigious tournament is just tremendous. Everything was really working for her today.
"As a team, we dealt with the same issue we've had throughout the fall season – inconsistency," she added. "We've shown that we have the ability to be as good as just about anybody in the Southland Conference – we just need to get more consistent from shot to shot and round to round."
The Islanders trimmed six shots from their team score in round one, shooting a 309 as a squad. Freshman Ana Paredes shot 76 in round two, while senior Lindsay Biehler delivered a 78. Senior Krista Fenniak and freshman Claudia Galindo each shot 88 in the second round of the event. The team sits 16th through the first two rounds.
Daytona State shot a 287 in the second round to surge into the 36-hole lead with a 580 overall. They hold a four-shot lead over Maryland (584), while host Florida International fell back to third place at 585. Missouri (587) and North Texas (595) round out the top five.
The third and final round of the Pat Bradley Invitational will tee off at 9 a.m. Updates will be provided at the conclusion of the final round on GoIslanders.com.


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In Their Own Words – Dear Future
This "In Their Own Words" is by Stuart Duncan. His son Cameron has autism and was diagnosed at two and a half. Stuart lives in Toronto, Canada. Check out his Facebook and Twitter.
Dear Future,
I have to be honest, I don't know you very well. I don't know if I can count on you or how reliable you'll be. I'd like to think that you have only good intentions and that you'll only get better, but I'm not naive. I know that you're just as uncertain as I am and quite frankly, that scares me.
You see, my child has autism and as such, the past has presented me with a lot of fears as well as challenges that I've had to learn to overcome. I've also had to learn how to teach my child to overcome them. The past tends to remind me of those that turned their backs on us, had nothing left to help us with, gave us a lot more questions than answers and basically dropped a bomb on us before leaving us to the cold. To put it mildly, the past has not been too kind to my family. I'd much rather forget the past and move on, which is where you come in.
Dear future, I'm coming to you with an open mind. I know you're not perfect and that there is already a lot of demand being placed on you. But I have to make you understand that I have a lot riding on you as well. I need you to be kind and compassionate. More so, I need you to have a lot of understanding and to be very accepting.
You see, I don't know how much longer I'll be around to take care of my child. And my child needs me so very much. Autism has made my child and I feel very alone in this world. We are looking to you to pick up where I will eventually leave off. I will be depending on you to be there for my child when I no longer can be and I'll be depending on you to be bright and loving.
I am doing the best that I can now to prepare my child for you, but that's a daunting task for the best of us. Since my child has autism, it's just so very much harder. My child needs more guidance, more support, more understanding and more acceptance. The present provides some of these things and it has been helpful. But if I wasn't here, it wouldn't be enough.
The present is very nice and friendly but to be honest, I feel like I'm in a dentist's waiting room and the present is the receptionist. I'm asked a lot of questions to which I answer, but have no idea what any of it means. I'm made to feel welcome with some magazine articles to read and the present even makes some small talk that resembles information sharing. But again, gives me no real answers.
For what seems like forever, I sit and stare at the present while they are constantly writing things down, filing things and taking phone calls from everyone and no one, while I sit there trying to keep my child calm. We're waiting for you… the future.
Dear future, I'm going to need for you to be prepared. I need for you to do more than just wait until I get to you. The past gave me an awful lot of questions for which the present had no answers to. I will be needing you to provide those answers.
I can't imagine what life will be like for my child if you don't have those answers. Answers such as where my child will live, and with whom. Will my child job have a job waiting? Will there be better medications and treatments available that offer more consistent results? Will there be love waiting for my child with the possibilities of a family as well?
I have no one else. You're it. I'm sending you my child whether you like it or not… for better or worse. Dear future, if you're not ready for that, please do whatever it is you have to do to be ready. My name will be called soon and my child will be needing you. So I'm needing you right now. Please be ready.
"In Their Own Words" is a series within the Autism Speaks blog which shares the voices of people who have autism, as well as their loved ones. If you have a story you wish to share about your personal experience with autism, please send it to firstname.lastname@example.com. Autism Speaks reserves the right to edit contributions for space, style and content. Because of the volume of submissions, not all can be published on the site.
December 16, 2010 at 1:38 pm
Mr. Duncan, Ur son Cameron is lucky 2 hav U 4 hia parent! Ur letter 2 Future shows Ur intelligence, kindness, patience, understanding & compassion in a beautiful way!! R U a writer? Of course, I CAN discern Ur fears 4 Cameron's future w/ in Ur words, 2, but Ur preparation 4 Future WILL certainly make Future kinder & gentler, yet strong & 4giving enuf 2 wrap Cameron in its arms & giv him the life ANY father can B PROUD 2 leave his son 2 ENJOY!!! TY 4 Ur loving concern 4 Cameron & Future: THEY WILL B QUITE THE COOMBO, THANKS 2 Y!!!!
December 16, 2010 at 5:23 pm
This is an awesome post that really captures the anxiety that all of us parents with kids on the spectrum feel with regard to our children's future. We're not just sitting around here in this waiting room twiddling our thumbs and waiting for the future to arrive…we are working our butts off in the here and now and hopefully that will pay off in the future of which you write.
December 16, 2010 at 8:37 pm
This is fantastic Stuart, good work!!
December 16, 2010 at 8:38 pm
As usual, great job Stuart. Since my son is now 13, I guess I am sort of in the future. For my family, as time goes on, our anxiety about the future seems to fade. Sure we still have worries but we have already lived through a lot of "what ifs" coming true and we survived. We know we will deal with the others as they come up. In the meantime, we try to stay in the day.
December 17, 2010 at 8:59 am
Our son was just diagnosed with Autism in October, he's 4 and a half…This letter is very moving for me…You described this perfectly…All the struggle of the past, I too hope stays in the past, while I look towards the future with blind hope that tomorrow is a better day full of hope and love and understanding for my son…I wish you and your family a Very Merry Christmas…
Danielle K.
December 17, 2010 at 9:08 am
You're absolutely right none of us knows how much time we have left on this earth.And what will happen to our children.Will they be able to survive without us or will someone take advantage or misuse them.I always have this fear in the back of my head.So i try to make my son as independent as possible.Their future is uncertain.A lot of parents have this same fear.That's why it's important for us to do what we can while we have an opportunity to do so.The article was wonderful you touched on many things a lot of parents feel.
December 17, 2010 at 9:19 am
Wow! Tear jerking and bittersweet.You expressed on behalf of many of us parents,so deeply the fear we feel for our children.I'm speechless…Thank You for sharing.
December 17, 2010 at 9:26 am
Very well written, and oh so true.
December 17, 2010 at 9:29 am
I loved your letter. You pretty much nailed it.
My son with PDD-NOS is now 8. His compassionate and perceptive sister is 10. They will be part of your child's future. I hope they will meet one day, because I could promise, together with my kids, they would help build the sort of community we'd wish for them.
But I understand your fears. Even as I try to offer the understanding and compassion to others that I wish to demand for my children, I've realized the pitfalls one can encounter doing this sort of thing. Believe it or not, being a friend to someone in need can be social suicide in some parts of the country. And we all know how hard finding yourself outside that big warm embrace can be. It would be hard to commit to, offering understanding if it means you too will be left out in the cold. And so, unfortunately, if feel there are plenty of those who understand but fear reaching out and sharing the compassion they feel.
How did we get so bad? I honestly feel today's demagogues are doing us this huge disservice, by fueling anger and supporting divisiveness bashed upon rash assumptions. Tapping into emotions without involving reason. I have hope that our current political malaise doesn't take a firm hold and become even more pervasive. But, if I can fight anything to build a future for my children, it is to fight this and every act of intolerance.
Best to you and your family, now and in the future.
December 17, 2010 at 9:29 am
Thank you for writing this incredible piece.
December 17, 2010 at 9:31 am
Thank you so much for writing this. My son just turned 4, and we are becoming more and more aware of the reality of the future – as we try to live in the moment and love each and every day. This article meant a lot to me, to know what I'm feeling is understood and shared – although I wouldn't wish this struggle on any child. Thank you so much.
December 17, 2010 at 9:49 am
Thank you for putting this out there. This is how I and many others feel but we have no clue how to say it.
December 17, 2010 at 10:04 am
Stuart, I share your fears as I am the mother of a teenage daughter with Asperger's. I think about the future a lot. Will she be able to maintain her own household without my help? Will she be able to hold down a job? How can employers overlook her behavior? Will she find someone to love her and with whom she can share her life?
But lately I've also been worried about the present. How can I continue to teach her life's lessons that others intuitively learn when I get so frustrated with her behavior? She IS a teenage girl afterall, and there is enough drama surrounding that without throwing in Asperger's. Will I be able to continue to hold on?
December 17, 2010 at 11:43 am
Thank you for sharing this incredibly moving piece with us. It brought tears to my eyes reading it. It was well written and so touching. I have a 3yr old beautiful son with austism, and it scares me to death what his future holds when I'm gone. God bless you and your family.
December 17, 2010 at 1:54 pm
Thank you this wonderful letter. This is what I feel everyday as a single mom to a child with autism.
December 17, 2010 at 2:02 pm
Being a parent of a child that is Autistic is a challenging, yet rewarding thing that we as parents can never explain to anyone else but to one another. We have learned to see things as no one else sees. We have learned to understand how the world works. Sometimes,or many times, it is a cruel world. We have learned what being a true parent is about. It goes beyond the first kiss. It goes to the first time in class. The first step. The first words. It goes to when he is having a meltdown, can use our code word, "Buddy", and he can come out of it by repeating it back to me. Be a parent of an Autistic child makes us a advocate for all children. I promise, my son's school know me on a first name basis. The future is in question. All we can do is do our best and encourage our children to do their best. That is what I will do. I will always be proud of my son, no matter what. Stuart, keep up the good work.
December 17, 2010 at 2:23 pm
Thank you thank you thank you for putting into words what most of us feel. I am terrified of the future and hope to live an extremely long life so I can support our now 10 year old son. I don't want him to be left in the cold and pray every day that he will be taken care of.
December 17, 2010 at 3:16 pm
Group homes, when properly funded and staffed seem to me to be the best answer for our older children, mine is 59. Letters and calls to our Representatives and Senators help bring this heartbreaking situation to their attention. I am in my 84th year and know that sooner or later I will have to leave this earth. My only consolation is that he is in a group home and receiving good care.
June Francis
December 19, 2010 at 3:30 pm
Your comments give me a good source to explore the possibility to bring some care of releif to my dear son and dougther they both have childs with autistm and the thinking about their future is alway a topic of fear , dear Lady if your son is 59 please if you can share some of the strugle you have in the early years when he need really someone to take care of him ,are this group homes really help for us .
We live in california .
Carlos , "BEN', Noel .
December 18, 2010 at 10:06 am
Mother of 15 yo Asperger's son. The future is what wakes me up at night worrying. I will save this moving letter into my journal. Thank you.
December 21, 2010 at 9:58 am
I totally undertstand. Is like I wrote it myself. My son is in need of a good and kind future too. Wish us well. I wish it to you.
December 22, 2010 at 3:41 pm
My son is 23 and has Asperger's. He is now in one of only two centers for intensive treatment in my state run by the state division of mental retardation and developmental disabilities. It is a wonderful facility and just what he needs. However, there are only 60 rooms at this facility and only the two facilities for the entire state at this level of treatment. Sadly, the only way he got in was that we had a major crisis where he became very upset, attacked my husband and was arrested. He is so much better in this treatment program and his placement there was the silver lining to the event. It is a tragedy that we do not have adequate services for these kids as they age and become adults. All of us need to work to advocate for appropriate group homes and day treatment centers as all of these beautiful children age.
January 3, 2011 at 10:06 pm
I have to say there are so many future things I just can't look at. Sometimes it feels as though we can hardly get through the present that the daunting task of even considering the future is quite frankly frightening. But here this is, this writing of yours Stuart that stops my breath and makes me think…and still, I'm frightened.
Beautifully written.
January 21, 2011 at 9:05 pm
Really wonderful post. I make the mistake of thinking to far into the future, spending too much time worrying about things we cannot know. With a 3yo, I'm still learning to live in the present, make the best of every day, and have faith that the work we're doing will pay off.
February 28, 2011 at 9:48 am
This letter could not have come at a better time because i too am dealing with Mr. Future. I thought Mr. Future and I were doing very well at building a relationship and moving forward with amazing results. One day you wake up and realize that the future does not run like clock work and that adjustments have to be made. Those adjustments and the frustrations take you back to those feelings of fear and helplessness. It is then that you reach out and find outlets of information and understanding to refuel the tank so that one can continue to walk the journey with Mr. Future. After the new setbacks that my son's autism has presented my family with your letter Mr. Duncan has given me the fuel I need to keep advocating and moving forward. It also let me know that I am not the only one on this journey. Thank you for such a beautifully written letter and the hope you inspire to all you are lucky to read your letter to Mr. Future. Blessings!
December 19, 2010 at 5:47 am
January 17, 2011 at 1:29 pm
January 30, 2011 at 10:57 am
February 26, 2011 at 12:19 pm
July 12, 2011 at 1:44 am


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5|25: Celebrating Five Years of Autism Science Day 9: Copy Number Variations
In honor of the anniversary of Autism Speaks' founding on Feb 25, for the next 25 days we will be sharing stories about the many significant scientific advances that have occurred during our first five years together. Our ninth item, Copy Number Variations, is from Autism Speaks' Top 10 Autism Research Events of 2007.
Three studies published in 2007 pointed autism researchers toward the importance not only of mutations within the DNA code of specific genes, but also of variations in the number of copies of genes, known as Copy Number Variations (CNV). Created by submicroscopic deletions or duplications of DNA sequences, recent advances have only now allowed CNV to become routinely detectable, establishing an entirely new avenue of genetic research.
Armed with the latest technology and three different collections of patient DNA, including Autism Speaks' Autism Genetic Resource Exchange (AGRE), researchers at Cold Spring Harbor scanned the genome for the presence of CNV in autism. In February 2007 they reported that not only do individuals with autism have more CNV than individuals without autism, but that CNV in autism occur more often as "de novo" or spontaneous mutations (mutations not found in the DNA of either parent). They also found that these spontaneous CNV appear to be more common in families with only one child with autism (simplex) than those with multiple affected children (multiplex).
With their data suggesting that genetic mechanisms may be different in different types of autism, the researchers then carefully studied the inheritance pattern of autism in the many families in Autism Speaks' AGRE and IAN databases. In July they published that they could fit the data to a model in which there are at least two distinct ways that genes may play a role in the development of autism: spontaneous CNV might help to explain autism in simplex families, whereas inherited gene mutations may be at the root of autism spectrum disorders in a greater portion of multiplex families. Such a model is significant because although autism has been thought to have a strong genetic component, so far it has not been shown to be as clearly inherited as other simple genetic disorders.
The team from Cold Spring Harbor has provided a new theory of autism risk that stands to influence how future autism genetic research is conceptualized. Although their results require replication, it also now leads to the question of what causes this increase in spontaneous CNV, opening the door to an exploration of the interplay between genetics and environmental factors. Possible risk factors include age of the parents, specific toxicological factors and accumulated exposures, as well as genetic predisposition.
Update since this story was first run: Improvement in DNA technology since the publication of this first major autism CNV study has meant that new insights into the role of CNV are actively being pursued. The largest and most comprehensive autism CNV study to date was published in April 2009 in the top research journal, Nature. The new study focused on inherited rather than spontaneous CNV, with the researchers finding CNV variations in genes important for neural development [for more details, see http://www.autismspeaks.org/science/science_news/top_ten_autism_research_events_2009_cnv.php]. Researchers in autism are continuing to lead geneticists in other fields with an intense focus on CNV and early recognition of their importance as potential disease risk factors.


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Discovery of World War II sub wreck brings closure to death of Dover veteran
The letter said the location of the submarine, 600 feet below sea level, made it impossible to attempt to recover or rescue the crew. Shelby wrote that the submarine sunk, �somewhere in the Atlantic.�
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The most recent MM&M Skill Sets Live event, "Personalizing the Healthcare Experience," surveyed a range of issues relating to some of the industry's hottest topics. This e-book conveys a wealth of information and opinion designed to help marketers demystify the challenges associated with the personalization of healthcare messaging. Click here to access.


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|By Salvatore Genovese
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|February 15, 2011 06:30 AM EST
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Re: Isaac (Ike) Taylor from a query of Roby Ottwell, first published in the July 2009 newsletter. "Isaac (Ike) Taylor, Mr. Ottwell's grandfather, …was killed in 1922 when a hired man killed Taylor and stole his money."
Society researcher and previous newsletter editor Shirley Bates went back to the Winnsboro News office (following the July newsletter) and asked to look at back copies of the Winnsboro News, but they didn't allow her to look because the newspaper is too old and fragile to handle. Then she went back to the library and tried again going through microfilm, this time from about July until December. Again, she didn't find anything. Member Dorothy Harbin was still looking in the microfilm at Quitman Library and looked at a site called smalltownpapers.com and it stated that there was a reprint in July, 1956 but she could never find the article. She looked in the Wood County Democrat (as Bates had done earlier) and the Wood County Echo, and found nothing.
Harbin also talked to a man named Taylor, and he had heard the story and had seen the rope on the water tower where the hired man was supposed to have been hanged, but it was frayed and had been up there quite some time. He said he was no kin but there are two other Taylor families in the county and that she might try to contact them.
Bates and Harbin both looked at the microfilm of the Wood County Democrat and looked through society books at the Quitman Public Library. Bates went to the courthouse to check on a death certificate, but Isaac Taylor was not listed in Wood County. The County Clerk suggested that since Winnsboro is in different counties, Wood, Hopkins, and Franklin, it's probably listed in one of their death index books.
According to Winnsboro News of Oct. 27, 1922, "killed on Sunday" in Sherman, one Maynard Taylor. Could this have been Ike, and he delivered to Sherman instead of in Wood County?
Bates wrote again to Ottwell Sept. 10, 2009 that Harbin had found "a discrepancy."
Harbin has found an article in a 1944 newspaper with an obituary or an article about Grogan (his mother's maiden name) Shoemaker. It stated that Grogan's father was the man who was killed by a black man and then the black man was taken from the jail and hanged from the water tower in Quitman. Harbin contacted the Dallas library and they looked it up and said that it was listed as Jan. 1, 1944. She found an article about his being very sick in the Wood County Democrat on Dec. 30, 1943, but the next newspaper (Jan. 6, 1944) is unreadable on the microfilm. She found Mr. Shoemaker's wife's maiden name from the marriage book in the genealogy room at the Quitman Public Library, and she also found some Shoemakers in the 1900, 1910, and 1920 censuses. The maiden name of his wife was Annie (Anniebell) Wallace Taylor and her father's name was Wallace Taylor.
Bates wrote Ottwell , "It's possible that whoever told you that Ike Taylor was killed in that way may have gotten him confused with Grogan Shoemaker. The Taylors lived next door to the Shoemakers. It's unfortunate, but many of our genealogy stories result this way because they are repeated over the years without documentation and people get confused." (Editor's note: the previous information is taken from a letter written to Mr. Ottwell by Shirley Bates in August 2009.)
Filed under: Queries Tagged: | Bates, Harbin, Ottwell, Shoemaker, Taylor


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Thanks Mark, There has been a burn ban for the last month, and the teepad and bench work made more sense than clearing brush into piles and moving the stuff twice. 16 is the current work in progress, with a double terrace necessary to make up the proper height. Being the pyromaniac in the crew, I MISS FIRE (and the associated hot dogs)! Mike, Mike, and Chris have designed and constructed the bulwarks around the teepads, with me and an assortment of others seeking out, and harvesting the osage logs they need. We are getting quite proficient at it! Thanks for the feedback.
Just a reminder, Monday is regular workday, we always are happy for any help, even for an occasional hour or two. Or, stop by and have a cool one and see what we do. A short BS session is always welcome. If any deck builder or home project guy has any scrap material to donate, PM me and we will see if we can use. Chris got a lead on some bricks and plants just today.


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The webinar will feature examples drawn from two companies at the forefront of internal combustion design that are improving their design optimization process by coupling Convergent Science Inc's CONVERGE® flow solver, Optimal Solutions Software's Sculptor® morpher and ESTECO's modeFRONTIER® optimizer.
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The Voyager Awards recognize those organizations that have contributed to Intel Cluster Ready advancement, total available market growth and helped penetrate the much sought after but elusive "missing middle" for customers moving to cluster-based solutions.
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AutoGrid is a fully automatic hexahedral grid generator for all types of rotating machinery: complex axial, radial, and mixed-flow configurations.
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I have RA. Was diagnosed at the end of August. I tried for several years to start C25K but the extreme fatigue and pain would always rear its ugly head....didn't know at that time I had RA. I knew I must have a problem but just never went to the doctor. Got to the point I couldn't ignore it any more.
I am taking meds...prednisone and plaquenil. Without the meds theres no way I could do this program. I'm hoping I have enough in my system that I won't have any problems. Are you on meds?
It's wonderful you are on wk5....I suppose you are further along by now.
"Failure Is Only The Opportunity To Begin Again More Intelligently" Henry Ford
"The most effective way to do it, is to do it" Amelia Earhart
What is "RA"? Runners Anemia?
Fat old man PRs:
(Rheumatoid Arthritis, shipo)
I presume you have consulted with your doctor. Though some will tell you "Oh, don't do that." I got quite a few hits when I googled "running with rheumatoid arthritis". Some looked like they offered advice, including the following.
I have seen a few other post here on Active but not a lot. I hope you have success with running and staying very active in general.
RA = Rheumatoid Arthritis - but it's more than "arthritis". RA is an autoimmune disease. Arthritis is just one symptom of Rheumatoid Disease. It's debilitating, deforming and very painful. Includes EXTREME fatiuge, joint/bone/muscle pain, brain fog, losing words, lack of concentration.....and sooo many other symptoms.
I never understood why people complained of RA - well now I know....RA ain't for sissys! haha
"Failure Is Only The Opportunity To Begin Again More Intelligently" Henry Ford
"The most effective way to do it, is to do it" Amelia Earhart
Len and DD64, thanks for the clarification; guess I couldn't have been more wrong if I tried with my Anemia guess.
I have "managable" (from a pain perspective) Osteoarthritis in both ankles (both of which have been broken in my distant past) as well as in one hip. I cannot imagine (or don't want to imagine) what it would be like to be dealing with Rheumatoid Arthritis; all y'all with RA have my best wishes being sent in your direction, hopefully it will help some.
Fat old man PRs:
I was diagnosed with RA 12 years ago. It has been a very bumpy road. I had a dream in my 30's to run a marathon. By 40 I gave up, I am now 52 an I have decided to believe in myself again. 2 days ago I decided to walk/run a marathon. I have booked an appointment with my doctor to see if I can have my knee's looked at and have a brace or anything done to endure this feat. I have been walking 2-3 miles a day now for 2 months and feel I could go much further but my knee hurts if I push it past this.
I don't have RA but have sjogrens and lupus both autoimmune and probably others, and there is a wide overlap in symptoms particularly the 'fun' pain in every part of body
and extreme fatigue or the 'living dead' feeling as I call it.
Without giving you my life story :-) ...I actually started severe problems around age 10, but in early stage autoimmune you get long period of remission, I was OK until
around 20 when I was on college running team. I was running around 4:40 for mile, 16min 5K, 33min 10K ....then suddenly, I couldn't run or exercise any more. I had
to rest completely for 1 year, my heart rate would jump to 170+ if I even tried to jog! .....I didn't start running again until age 40,to try to help anther worse flare age 38.
Advice, well, don't give in and well done for trying to fight through the pain and the mental battle's that only those with this can understand, you have to be a warrior just
to get out and run many days! ...but, you will feel better for it.
Like any warrior, you won't win every battle, some days you need to know when to call it quits and rest ...its a careful balancing act of trial and error.
fwiw I've managed to get back to running 15-20miles a week, that's the most I can handle, and because of my background in competive running I still have some speed so most people would never know what I go through to run, infact most will probably think your just whining about RA ...so get ready for how annoying that is!
I would look very carefully at your diet, prednisone helps but long term there are issue's, I got off it after 2 years, and found removing alot of foods helped alot - you can try and elimination diet (google it) ...I tell everyone this but very few people try it, those that do nearly always find a bunch of problem foods - most common - gluten, dairy, soy, corn ..and most processed foods.
Nightshade family is also implicated in RA ...potato, tomoto, peppers ...yep, sucks if they are a problem ... mainly exists on green drinks, rice and fish....very restictive but I prefer to feel better.
fyi - Running seems to particularly help me, I believe because it raises cortisol which is a natural biological process to taking prednisone i.e. to supress over active immune system. I also lift weight and bike, swim but they have never helped the same way.
Careful though, I found anything over 50minutes running made me feel worse...flaring up aches, exhaustion etc
Best of luck
ACTIVE is the leader in online event registrations from 5k running races and marathons to softball leagues and local events. ACTIVE also makes it easy to learn and prepare for all the things you love to do with expert resources, training plans and fitness calculators.


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Bono Warns Fiscal Cliff Cuts Will Hurt World's Poor
Bono Warns Fiscal Cliff Will Hurt World's Poor
Even Bono is worried about the fiscal cliff.
The lead singer of Irish band U2 says spending cuts that hit in January would devastate programs to help the world's poor, leading to more than 60,000 deaths.
"There's real jeopardy," Bono said Wednesday at a discussion at the World Bank with bank President Jim Yong Kim. "I'm still terrified of people wrestling the wheel of this mad lorry that they're driving off the cliff."
Sequestration — a package of automatic spending cuts set in motion last year — would slash funding for U.S. programs grouped in the federal budget as "international affairs" by 8.2%, or $4.7 billion, in the current fiscal year. Bono said that includes about $2 billion from anti-poverty programs, such as treatment for HIV/AIDS, on which he focuses at his anti-poverty advocacy group, ONE.
"We know there's going to be cuts," he said. "We understand that. But not cuts that cost lives."
Bono spent Tuesday making the rounds in Washington to press leaders in both parties to avoid going over the fiscal cliff and protect antipoverty programs. He met with Vice President Joe Biden and other White House officials, House Minority Leader Nancy Pelosi, House Majority Leader Eric Cantor, Sen. Marco Rubio (R., Fla.), Sen. Lindsey Graham (R., S.C.) and numerous other senior lawmakers.
He said Wednesday he's "at least encouraged by the commitment" from lawmakers on both sides of the aisle to supporting antipoverty programs included in the foreign-aid budget, which accounts for less than 1% of the overall federal budget.
More In Fiscal Cliff
- What Economists Think of the U.S. Defaulting on its Debt: 'We Aren't That Stupid!'
- Prepare for the Return of Budget Battles, Debt Drama and Other Washington Uncertainty
- Secondary Sources: Possible vs. Probable, Fiscal Cliff Again, Better Off
- Consumers Skid From Fiscal Cliff to Oil Slick
- Young Executives' Mood Improves
- Fiscal Cliff Didn't Hold Back Business Spending
Bono cited data from the American Foundation for AIDS Research that budget sequestration would eliminate HIV/AIDS treatment for 276,500 people and could lead to 63,000 more AIDS-related deaths and 124,000 more children becoming orphans. The group also estimates as many as 11,000 more deaths from tuberculosis and 6,500 additional deaths from malaria due to the cuts. (Sequestration would also cut funding to other development programs, including for nutrition and food security.)
At the event Wednesday, Bono praised the World Bank's efforts to accelerate reductions in extreme poverty around the world. Dr. Kim and other development officials maintain that providing aid for health, education and social-protection programs helps create more emerging economies, like the ones in Latin America, Asia and Africa that have held up global economic growth in the past five years. "For us to pull back now I think has to be understood as undermining the foundations of future growth of the global economy," Dr. Kim said.
Bono put it more simply: Without recent growth from emerging countries, "we would be f—–," he said, whispering that last word. "We owe them. The emerging markets are keeping us all afloat."
"The best medicine to keep us afloat is more countries moving from being LDCs [least-developed countries] to being middle-income countries," he said.


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Fireworks fans no longer need to travel to Tennessee or another state to buy fireworks. We can purchase them right here in Taylor County.
A new amendment to state law allows us to have fireworks that shoot into the air. While we have an opportunity for more fun, we also have the responsibility for safety.
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NH's June revenues $9M ahead of estimates, with $2M from MtBE settlement
The state took in $9 million more in revenues in June than projected. The state also got more than $2 million from settlement of a lawsuit over fuel additive MtBE.
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The Molecular Biology Section (MBS) is directed toward a precise molecular understanding of critical interactions that initiate, control, and perpetuate the immune response. To this aim, the laboratory focuses on
In recent years, the major accomplishments of MBS have included determination of the structure and function of the CD8 alpha beta T-cell coreceptor in complex with its MHC-I ligand, studies of the mechanism of peptide loading of the MHC-I molecule, and studies of the structure and function of viral immunoevasins. These last advances include the determination of the structure of the complex of the mouse cytomegalovirus MHC-I-like molecule m152 in complex with its ligand RAE1.
Using purified MHC molecules, viral immunoevasins, TCR, and NK receptors, we have learned the thresholds of affinity that allow such cell surface receptors to activate or inhibit effector-cell function. Based on X-ray crystallographic studies of these components and of their molecular complexes, we now understand in molecular detail the mechanism of peptide loading of MHC-I molecules, the basis of molecular recognition of TCR for MHC-I and MHC-II molecules, and the structural basis for interaction of T-cell coreceptors with MHC molecules. X-ray structures of MHC-II/peptide complexes that are crucial to the development of autoimmunity provide insight into the molecular basis of autoimmunity.
Our recent studies of viral immunoevasins reveal the structural evolution of viral resistance to recognition by the immune system and provide opportunities for developing strategies to counter such viral evasion. In addition, our broad understanding of the structure-function relationships of MHC molecules has permitted us to explore the relationship of MHC-I structure to HLA-linked drug-induced hypersensitivity syndromes. We are currently developing mouse model systems to allow further exploration of the molecular and cellular basis of such HLA-linked syndromes.
Dr. Margulies received an A.B. from Columbia University in 1971. In 1978, he earned his M.D. and Ph.D. from the Albert Einstein College of Medicine. From 1978 to 1980, he served as a resident in medicine at Columbia/Presbyterian Medical Center. From 1980 to 1983, he worked as a research associate in the Laboratory of Molecular Genetics at the National Institute of Child Health and Human Development. From 1983 to 1987, he was an investigator in the Laboratory of Immunology. In 1987, he became a senior investigator and, since 1989, has been chief of the Molecular Biology Section. Since 2008, he has been a member of the Senior Biomedical Research Service.
Phi Beta Kappa; U.S. Public Health Service Commendation Medal, 1987; Outstanding Service Medal, 1991; Meritorious Service Medal, 1997; Distinguished Service Medal, 2001; NIH Merit Award, 2009 (Tetramer Facility Team)
Immunology, Structural Biology
Lisa F. Boyd, Rosalene Carey, Michael G. Mage, Nathan May, Giora Morozov, Kannan Natarajan, Mulualem Tilahun
Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3578-87.
Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH. The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J Immunol. 2012 Aug 1;189(3):1391-9.
Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, McMurtrey C, Vernon S, Hildebrand WH, Buchli R. Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS. 2012 Jul 17;26(11):F21-9.
Revilleza MJ, Wang R, Mans J, Hong M, Natarajan K, Margulies DH. How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance. J Biomed Biotechnol. 2011;2011:724607.
Zhi L, Mans J, Paskow MJ, Brown PH, Schuck P, Jonjić S, Natarajan K, Margulies DH. Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms. Biochemistry. 2010 Mar 23;49(11):2443-53.
Wang R, Natarajan K, Margulies DH. Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position. J Immunol. 2009 Aug 15;183(4):2554-64.
Visit PubMed for a complete publication listing.
Last Updated August 19, 2013


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- Show Some Love for Denmark
- Currently Unavailable
Join up with the Olsen Gang when you're wearing this official Denmark home jersey from adidas. This TechFit jersey fits snugly for optimum performance and has the team badge and adidas logo at the front. Polo collar makes sure you look classy on the pitch.
This jersey also includes a 14" x 5" x 12" bag with one main compartment, outer pocket and the Danish Football Association and adidas' team logo screened at front.
Suit up like Daniel Agger and the rest of your favorite Danish soccer stars with this jersey.
100% polyester. Imported.
NOTE: Tight fit, which means any jersey classified as Authentic will run small. The authentic is the actual piece that is worn on field. The authentic uses a performance cut for a snug fit. It also has a bonded crest. The authentic also features upgraded materials. The upgraded materials on the authentic result in a lighter weight.
Lamentamos que todavia no hay descripción en español para este producto.


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Winter Energy Saving Tips
Stay warm and reduce your energy use this winter with these simple tips from Duke Energy.
No-sweat advice for heating your home
- Change your filter
So, whats the big deal about changing or cleaning the air filter(s) at home? Were glad you asked! A dirty filter makes your heating system work harder, which uses more energy. Simply replace your filter every few months or opt for a washable one they can last up to five years. And dont forget: changing your filters can cut down on dust around the house.
- Maintain your system
You probably change the oil in your car more than once a year. You should also properly maintain your heating and cooling system with regular service calls from a licensed technician. Like air filters, dirty coils and fans reduce airflow through your heating and cooling system. Annual or semi-annual check-ups can improve your systems efficiency and prevent costly repairs.
- Program your thermostat
You can save around 10 percent a year on your heating and cooling bills by simply turning your thermostat back 10 to 15 degrees for eight hours a day. If that sounds like a difficult task, then you should think about installing a programmable thermostat. Programmable thermostats allow you to automatically set specific temperatures at different times of the day.
- Use your fans
The ceiling fans in your home are a great way to stay cool in the summer and warm in the winter. Simply set the fans to operate in a clockwise direction. This will push warm air, which collects near the ceiling, back down into the room. And dont forget to shut off ceiling fans when youre finished in a room. Doing so will just add to your energy savings.
Keep your head above water
- Clean in the cold
Ninety percent of the energy used by washing machines goes into heating the water. But most clothes don't require hot water to get a good cleaning, so think about using the cold water setting next time you do a load of laundry. Your regular detergent should work just fine, or you may want to try special detergents designed especially for cold water use.
- Rinse before you load
As much as 80 percent of the energy your dishwasher uses goes to heat water. So, try turning off the pre-rinse option in favor of rinsing your dishes before you load them in the dishwasher. Also, youll be on your way to additional savings if you run the dishwasher only when its full.
More power to you
- Turn down the brightness
Some newer TVs are automatically configured for "store" mode, which is a brighter, high-energy mode set by manufacturers before theyre shipped to stores. It's fine for attracting attention in a showroom, but may be unnecessarily bright for your living room. Try out the "home" setting for a better picture, longer TV life and energy savings of up to 30 percent.
- Unplug the unmentionables
Energy vampires loom in and around your home. Devices like your cell phone charger, gaming system and power strips use energy even when youre not using them. Think about unplugging certain electronics that you dont use on a daily basis. Then try to change the way you use other equipment. For instance, if you dont think youll use your computer for two hours, consider shutting it down. And only turn on your printer when you need it.