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Between Sawgrass and Seagrass
Welcome to NatureScape Broward, a vision for the community that starts in your own backyard. NatureScape is about creating Florida-friendly landscapes that conserve water, protect water quality, and create wildlife habitat. The NatureScape vision includes all Broward County residents and all types of properties - from homes to businesses to public facilities to schools. This website shows how to transform a yard, school, public or business landscape into a certified NatureScape.
Did you know that landscape irrigation accounts for up to 50% of water consumption in Broward County? Or that landscape runoff is a major source of water pollution? That is why NatureScape is an important part of Broward County's water conservation program Water Matters. For People. Plants. Animals. Our plant choices and the way we maintain our yard can greatly impact our future water supplies.Who doesn't want to protect this beautiful place we live? Broward is a very special location between the Everglades and the Atlantic - between sawgrass and seagrass.
NatureScape encourages the use of native plants in landscaping. These plants are uniquely adapted to grow in South Florida. Natives generally require little watering once established, and are naturally pest resistant, which means less use of expensive and toxic chemicals. So by using native plants we conserve water and reduce pollution while maintaining a healthy landscape. NatureScape is part of the Broward County's overall water resource management plan - the Integrated Water Resource Plan (IWRP). This plan was developed to ensure there is enough quality water for everyone, today and in the future. As part of the IWRP, NatureScape provides simple, common sense techniques to conserve water and protect our water supply through our daily activities.


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By Taylor Gilmore '15
On February 8 in New York City Delaney Ratner '16 (resource economics) took the ring with her border collie, Kelso, to compete in—and win—the first ever agility competition at the prestigious 138th annual Westminster Dog Show.
As they streaked the obstacles, Ratner says she didn't hear the oohs and aahs emanating from the crowd "I try to focus on my dogs and run them like I would in my backyard," Ratner says. "It's really about centering yourself and doing what you need to do for your dog."
Still, Ratner couldn't help but sense the difference between Westminster and the many other competitions she's attended, noting, "It's louder and there are cameras in your face!" Certainly after she won, she became the media darling. When we spoke with Ratner a week after she and Kelso cinched the championship, the interview requests were still flooding in! A quick Google search will show that media from around the world ran the story of their outstanding win.
Ratner began competing at age six, but started agility training and showing in regional and national competitions with Kelso in 2010. Her mom, Cindy Ratner, who has been involved with competitive obedience since the late 80s and started doing agility a few years before Ratner did, helped her get involved.
"I have yet to compete internationally," says Ratner, "but in 2012 Jonesy, my 9-year-old miniature schnauzer—who won the 12" Championship at Westminster this year—was named an alternate to the World Agility Open team, and in 2013 Kelso was an alternate for the World Agility Open team."
"A commonly used philosophy in agility training is to train your weaknesses and compete to your strengths…it's really just a balancing act," says Ratner . "My whole life has been a balancing act."
In high school, Ratner played sports, was involved in many extracurricular activities, and took on a difficult course load, all while competing, training, and instructing dogs. Not much has changed since then, as Ratner continues her active lifestyle at UMass.
When Ratner first came to UMass she thought accounting would be her course of study, but then found resource economics particularly interesting. Because it is applied economics, Ratner found the concepts straightforward and understandable.
On the extracurricular front, Ratner is the treasurer for the Cannabis Reform Coalition and in the midst of planning for the 23rd annual Extravaganja political rally and music festival on Amherst Town Common. "I also try to help out with the Divest UMass movement as much as possible," said Ratner. Divest UMass is a student organization that wants administrators to take charge of how UMass' endowment hedge fund is being managed by freezing and phasing out investments in fossil fuel industries. "I think the cause is incredibly important to the future of our school and our society."
One of the main reasons Ratner, who is from Cape Elizabeth, Maine, chose to attend UMass is because of Amherst's proximity to Westfield, Springfield, and Greenfield, where many agility events take place. She also found UMass appealing because it is a big, out-of-state school offering a broad assortment of majors and opportunities. "You have to be willing to seek out resources and opportunities, but UMass provides something for everyone. So far it has been an amazing experience," says Ratner.
"My biggest difficulty has been exams vs. agility," Ratner reflects. "Since competitions are not a 'university sanctioned' excuse, if my professors aren't particularly understanding of my circumstances, I end up studying at big events, which is really unfortunate. International Team Tryouts, for example, fall the first weekend in May, right before finals week. Last year I flew into Bradley Sunday night, getting back at 1:00 a.m., and then took an 8:00 a.m. final that my professor wouldn't let me take earlier or later."
Kelso has been in Ratner's life since she was 16 and they've been training together ever since. When she came to Amherst, Kelso did too, though he does go home to Maine during crunch times to keep up training with Ratner's mom.
When Kelso is in Amherst, Ratner works mostly to keep him in shape, focusing on cross training and core strengthening exercises. They hike Mount Norwottuck and Bare Mountain often, and Ratner uses stretching and training tricks to keep Kelso learning.
"I want to compete internationally and win a world championship. It's the highest award in dog agility to win AWC [Agility World Championship]," says Ratner. She hopes to take her mom's sheltie, Zep, to the world stage next. "I plan on trying to get the best out of my dogs and keeping them and myself as fit as possible," she says.
"My favorite part of training is watching my dogs learn and seeing their skills slowly start to develop into complex behavioral chains. It creates such a strong bond between trainer and dog. I love it," said Ratner. "It's been an incredible ride so far and I can't wait to see what the future brings."
To watch a video of Kelso's agility performance, click here.
Taylor Gilmore '15 (communication/journalism) is communication assistant in the Dean's Office of the College of Social and Behavioral Sciences.

subset: commoncrawl


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Featured Events
This ensemble theater piece, the first-ever themed production for TMI Project, is about all the different ways reproductive "choice" is exercised by women – and men. The performance and silent auction will benefit both Planned Parenthood Mid-Hudson Valley and the Community Outreach Initiative of the TMI Project.
What to Expect When You
Saturday, June 29, 2013
Music, Food & Auction 6pm. Performance 8pm.Bearsville Theatre
Woodstock, NY
Price: $45 in advance / $50 at the door.Age:Recommended for Adult AudienceBuy Tickets


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a fresh breeze is blowing on the Tolbiac Hotel with brand new ventilator
In order to ensure that your stay will be as confortable as possible, we installed ventilator in every room of the Hotel. The heat won't trouble you anymore, and you can still enjoy our flowered patio to relax on warm days.
And with Promo code 8, - 20% on every room form 10 july to the 31 August
during the dates of the Paris summer fair 2012. Click-here to read more.


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FRM victims worried House will kill bill seeking state restitution
CONCORD – A House panel deadlocked 10-10 Tuesday on whether to kill legislation granting state restitution for the victims of the Financial Resources Mortgage scandal.
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The weather was hot. But the chili was hotter.
For the 33rd year in a row, Palo Alto celebrated all things meaty with its Chili Cook-Off and Summer Festival in Mitchell Park on Friday.
"This is the top of the line, I think, for us," said Minka Van Der Zwaag, the city's recreation program supervisor. "This is this one that brings the most community members together."
More than 8,000 people were expected to attend the event, which for the first time featured ice cream tasting. The World Cup match between Brazil and Columbia was also beamed into the park.
The competition between the 14 cook-off entrants this year was just as fierce as the one on the soccer field. The judging, which is always done blind, was a similarly serious affair.
"We pay for their booths and we pay for their health department permits," Van Der Zwaag said about the teams. "But all the ingredients -- it's up to them. So, it's serious. We want to respect that seriousness."
Palo Alto Councilman Marc Berman and Mountain View Councilman Mike Kasperzak put down their judge's clipboards for a few minutes to articulate what makes a chili award-winning.
"It's funny how it really, like, hits you in the face in terms of preferences," said Kasperzak, who has judged the cook-off a total of three times. "I really went for the smoky bacon."
"For me, you've got to be able to stick a fork in it," two-time judge Berman said. "If the meat has great flavor, that's a huge plus on one side, but if it's just in a sauce base, that's not a chili."
At the Rich Chili booth, Rich Ford was playing it cool while soaking in the sunshine. His team of four chefs, three of whom work for Bon Appétit at Google in Mountain View, captured the top honors of "best overall chili." They also placed first in the open division for the second year in a row.
"We just come out here to have fun," Ford said as more than 100 people stood in line for a taste of the team's chili. "We all like to do what we do and that's cooking. We all have good palettes."
Ten booths away, cook-off veteran Jodi Scherer of Elmo & The Old Quackers said she believes the secret to great chili is "texture." Of course, the right mix of spices is also critical.
"You want to taste the chili and then have the burn," Scherer said. "You don't want to have the burn up front."
Palo Alto Professional Firefighters Local 1319, another perennial contender, tried a different approach this year, said firefighter-paramedic Jesse Wooton. The team opted for four types of peppers -- poblano, jalapeno, serrano and bell -- instead of its traditional pepper sauce.
"We call it fire-roasted chili," he deadpanned.
Wooton said the firefighters, who spend their own money on ingredients, look forward to the cook-off every year.
"We love doing it," he said. "We love working together in Palo Alto. We love working with the community. This is the one day of the year we really get to interact with the public."
Debbie Robinson, of Mountain View, gave the event high marks. "They have line dancing and water balloon fights," she said. "It's totally old-fashioned family fun."
"It's a place to hang out with your friends and have a good time," added her friend, Staci Martinez of San Jose.
Back in the judge's booth, Kasperzak revealed one of the hidden perils of judging the cook-off.
"I'm glad I spent the last six months losing 30 pounds," he said, "because I gained it all back today."
Email Jason Green at firstname.lastname@example.com; follow him at twitter.com/jgreendailynews.
Best Overall: Rich Chili
First place: Rich Chili
Second place: Elmo & The Old Quackers
Third place: Lounge Lizard Chili
First place: EPA Can Do
Second place: Golden Slaters
Third place: Team Vineyard
Best Booth: Elmo & The Old Quackers
Best Spirit: Palo Alto Family Y & The Ace of Sandwiches
People's Choice: Team Vineyard
Youth's Choice: Team Vineyard


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The National Weather Service has confirmed that wind damage near Pope Saturday night came from a brief tornado.
The twister touched down for about two minutes near the Panola County town starting about 9:55 p.m. and had peak winds estimated at 112 mph.
The weather service said the tornado stayed on the ground for about a half mile and had a path 75 yards wide. Two houses and two sheds had roof damage, while a shop was destroyed. A recreational vehicle and a flatbed truck were overturned.
Hail was reported across the northernmost parts of Mississippi Saturday night. Some isolated tree damage was reported in addition to the Pope tornado.


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If you are looking for a quick and easy way to dress up your pooch, this is the perfect option! All you have to do is snap on this shirt collar! Your dog will go from sloppy to fabulous in seconds with this lovely shirt collar!
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30 September 2011
Pneumococcal Advance Market Commitment: Lessons Learnt on Disease and Design Choices and Processes
This document describes early lessons learnt on the selection of a target disease, on core design choices, and on processes related to the pilot Advance Market Commitment (AMC) for pneumococcal vaccines. While ongoing monitoring and evaluations scheduled for the coming years will provide further information about the value of the Pneumo AMC, this document highlights some of the key lessons to date and aims to provide a starting point to inform discussions about the potential applications of the AMC concept to other vaccines or health and non-health interventions.
26 May 2011
Market shaping: strategic considerations for a healthy vaccine marketplace
GAVI aims to have a lasting impact on the vaccine market to ensure a sustainable supply of affordable, safe and effective vaccines. To understand how GAVI can be effective in this area, it is important to consider the role and relative importance of the Alliance in the global vaccine marketplace.
Building ownership and sustainability: Country co-financing of vaccines
Combined with GAVI's focus on market shaping to decrease prices over time and efforts to raise predictable financing, GAVI's co-financing policy is a key strategy to ensure long-term sustainability of immunisation programmes in countries receiving GAVI support.
Ethics hotline
Concerned about the misuse of Gavi resources? Report it now.
© Gavi 2016
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Ill. researchers build 'vanishing' tech gear
Published: Tuesday, July 16, 2013 at 8:50 a.m.
Last Modified: Tuesday, July 16, 2013 at 8:50 a.m.
URBANA, Ill. (AP) — Imagine this: There's no need to throw out your old cellphone, because it will self-destruct.
That's the idea behind a project at the University of Illinois at Urbana-Champaign, where researchers are investigating how to build electronics that vanish in water.
John Rogers is a professor of Materials Science and Engineering at the university. Rogers says the goal of the "born to die" program is to design transient technology that can dissolve at the end of its useful life, thus saving space in landfills and reducing waste.
The research team isn't there yet. But it has designed a chip built on a thin film of silk that dissolves when hit with water.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Head wrestling coach Dave Wingert paces the wrestling room at Yellow Medicine East High School surrounded by nearly 57 wrestlers as he counts off a number of post-practice announcements before his excitement begins to rise and his semi-circle steps quicken; his words bunch up and his hands come down on each sentence as if he was hammering in the punctuation.
Naturally, he's an excitable guy, you envision him as the high school wrestler who could never leave the mat-room—and now he's swept up in it with his own team—a team that now legitimately fills the room with wrestlers from three different schools.
"Friday (hammer). Saturday (hammer). Were two of the best practices I've ever been apart of since I've been coaching (hammer). We had wrestle-offs today that were as intense as anything we've had here. It's all about competition (hammer). You've got to have great competition in the room before you can go out and be competitive on the mat. And we've got competition here."
In bold letters made of all-caps the back of Wingert's shirt reads "three schools—one goal". The front reads "Quad County Wrestling".
He rousts up his wrestlers to break practice as a group. "Quad County," offers his team as they surround him with there hands reaching for the center of the circle. But the coach isn't happy. "That's the worst we've ever broken it down, guys get back in here." They go again.
From there the team disperses. Wrestlers from the MACCRAY, Renville County West and YME school districts. They drift out from the current center of their universes, walled with mats and stinking of sweat, to return home to Renville, or Sacred Heart, or Maynard, or Clara City, or Clarkfield, or Granite Falls and all parts between; expanding outward into the ether like the exploded remnants of a super nova.
"I've been through this now three times," says assistant Quad County wrestling coach Darrel Refsland who has deep wrestling roots that extend from Renville and Sacred Heart to Granite Falls and Clarkfield. "I was here back in 1988, or '89 when Granite Falls first paired with Sacred Heart and Renville for wrestling. Then I was here again when Granite Falls and Clarkfield combined. Now this time," said Refsland when asked about the new wrestling coop between Yellow Medicine East and what had been a coop between MACCRAY/RCW.
"There's a lot more competition and it's definitely made us a better wrestling program," said Refsland. "No, it's not a win-win totally. Of course there's going to be some kids—some seniors especially who'll be disappointed— but they will have chances throughout the season to get back their spot. And they have to buy in to the team concept."
Page 2 of 2 - Wingert uses his own example when addressing his wrestlers, "the most exciting years I had as a wrestler were when my team was winning—not just when I was winning."
For this team, Wingert counts off the positives he's already seen: Numbers were even better than expected, kids that had quit wrestling at all the schools have come back out, he's seen excitement from all the communities Quad County represents, practices have been awesome and intense. And then there's that "buzz" in the room.
"We're going to have close wrestle-offs all season. It's pretty neat to have that kind of competition in the room—all that extra energy," says Wingert.
Location, ST | website.com


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What You'll Need: scriptures, GAB 72/GAK 305: Enos Prays, printed coloring pages and coloring tools.
You can also choose to download the pdf of LESSON 22 for easy printing. If you download, please leave a comment here on what you like about this lesson. Note: GAK vs GAB pictures explained here.
Scripture: Mark 11:24 - Therefore I say unto you, What things soever ye desire, when ye pray, believe that ye receive them, and ye shall have them.
Opening Song: A Child's Prayer (PCS#12)
Today we are going to learn about a scripture hero. His name is Enos.
One day Enos went into the forest to hunt animals. He began thinking about the teachings of his father. He had often heard his father talk about eternal life and the joy of those who keep God's commandments. Enos wanted to have that joy.
(show GAB 72/GAK 305)
He knelt down and prayed to Heavenly Father to forgive him of his sins. Enos prayed all day and into the night.
- Have you ever prayed all day and all night? Why do you th8ink Enos prayed for so long?
While Enos was praying, he heard the voice of the Lord say to him, "Enos, thy sins are forgiven thee, and thou shalt be blessed" Enos knew his sins were forgiven.
Enos wanted all the Nephites to feel the joy he felt, so he prayed for them. The voice of the Lord again came to his mind. The Lord said He would bless the Nephites if they kept His commandments.
Then Enos prayed for his enemies, the Lamanites. The Lamanites were wicked. They fought the Nephites, trying to destroy them and their records. He wanted the records of his people (or scriptures) to be preserved so that someday the Lamanites would read them and believe. The Lord said to Enos, "I will grant unto thee according to thy desires, because of thy faith".
Enos was happy. He spent the rest of his life preaching the gospel of Jesus Christ.
As children of our Heavenly Father one of our greatest privileges is to communicate with Him in prayer. Heavenly Father loves you. You are His child. Joseph Smith and Enos both prayed in a forest. Moses prayed on a mountain. We often pray in our homes and in church. We can also pray at school, on the playground or anywhere else we want. Heavenly Father wants you to pray to Him often—anytime, anywhere.
Bear your testimony about prayer. Share a specific time in your own life when you prayed at an unusual time or in an unusual place and how that prayer was answered.
(For tips on sharing your testimony please click here.)
Practice Song: If you are teaching your family the JUNE Song of the Month, go over the words and music with your family.
Activity: Coloring Pages
1. Enos Coloring Page
CLICK HERE to open and print.
2. Prayer Coloring Pages
CLICK HERE to open and print. Choose boy or girl page as needed.


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Fire damages Hendersonville home
Published: Friday, October 25, 2013 at 7:12 p.m.
Last Modified: Friday, October 25, 2013 at 7:12 p.m.
The Hendersonville Fire Department was called to a home Waterside Drive in the Brookside community around 4:45 p.m. Friday for a structure fire.
Hendersonville Fire Chief Dorian Flowers said they suspect the fire started outside of the left exterior wall of the home and worked its way into the home's crawlspace.
One woman was inside the structure when the fire crawled in, but she escaped without injuries.
Flames were extinguished by 5:15 p.m. and firefighters used a pressurized fan to clear the house of smoke in hopes of preventing any further damage.
The cause of the fire is being investigated.
Valley Hill Fire & Rescue, Mountain Home Fire Rescue, Henderson County Rescue Squad and Henderson County EMS assisted the Hendersonville Fire Department.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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NORMAN, Okla. -- A television station in Oklahoma City is reporting that Joe Mixon, the University of Oklahoma running back from Freedom High School in Oakley, will have one misdemeanor charge filed against him for an incident in which he was accused of hitting a woman.
According to koco.com, the Cleveland County, Okla., district attorney's office will charge Mixon with one count of an act resulting in gross injury, which is a misdemeanor charge in Oklahoma.
Authorities say Mixon was involved in an incident at Pickleman's Cafe on July 25. One of the top recruits in East Bay history, the freshman running back was accused of hitting a woman who said she had broken bones in her face as a result of the incident.
The TV station said Mixon's attorney, Kevin J. Finlay, asked that charges be filed against the woman, but it was unclear if that has happened.
"As we have maintained from the beginning, it is our belief that Joe reacted instinctively after being racially slurred and physically assaulted by a highly intoxicated young woman and her male friend," Finlay, an attorney in Norman, Okla., said in an e-mail to this newspaper and several other news organizations. " We strongly disagree with the series of events as portrayed by Norman PD. Justice knows no gender bias and we do not believe that Joe's actions were criminal in nature.
"We are also disappointed that it appears that no assault and battery charges will be filed against the young woman for her actions on the morning of July 25th."
Mixon hasn't attended team activities at Oklahoma since the incident happened, koco.com said. The university had no comment on the charges as of early Friday afternoon, the TV station said, adding that a statement may be released later in the day by Oklahoma.
Finlay's e-mail said Mixon is hoping to continue as a student and an athlete at Oklahoma.


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This blog entry is third ([URL="http://blogs.sun.com/arungupta/tags/javaee6+community+feedback"]previous ones[/URL]) in the Java EE 6 feedback from the community series. You can learn about how Java EE 6 is currently being used in production, development and deployment environments used within the community, and even feature requests for Java EE 7.
This entry comes from [URL="http://www.antoniogoncalves.org/"]Antonio Goncalves[/URL] - a senior software architect specialized in Java / Java EE working as a consultant. He started working with Java in 1998 and quickly with J2EE in 1999. He published a first book (in French) about Java EE 5 in 2007 and became a JCP Expert Member of various JSRs in 2008 (Java EE 6, JPA 2.0 and EJB 3.1). He is a member of the [URL="http://www.ossgtp.org/xwiki/bin/view/Main/WebHome"]OSSGTP[/URL] (Open Source Solution Get Together Paris), co-leader of the [URL="http://www.parisjug.org/"]Paris JUG[/URL] and has been awarded Java Champion. Follow him on Twitter ([URL]http://twitter.com/agoncal[/URL]) and read his blog ([URL]http://agoncal.wordpress.com/[/URL]).
Here is a short summary of Java EE 6 from him:
[B]Jigsaw puzzle, Modular, standard, less xml, easy, easy, have I said easy?[/B]
Read on for other fun stuff ...
[B]1. How are you using Java EE 6 today? What limits your adoption ?[/B]
[I]The first use case of using with Java EE 6 is to develop anything I need to develop, any prototype.[/I]
[LIST] [*][I]Need to write a quick task processing a database? Java EE 6.[/I] [*][I]Need to develop a quick admin site with a few pages interacting with an LDAP directory? Java EE 6.[/I] [*][I]Need to expose a RESTful web service? Java EE 6.[/I] [/LIST] [I]The platform became so integrated, as well as being so modular, and so simple to use, that any simple use case is a perfect excuse to use Java EE 6 (take a transactional EJB 3.1, a few JPA 2.0 entities, package everything in a war, no interfaces, no XML, and you are done).
The second use case is to use some bits of Java EE 6 as a jigsaw puzzle at my customers. The beauty of EE 6 is that most specifications can be used separately. At the moment I'm using Bean Validation and JPA 2.0 under Tomcat, no need to use the full platform not to deploy it to a full compliant application server.
In my case, Spring is limiting a wider adoption of Java EE 6. Only very recently Spring Web Flow has started to support bits of JSF 2.0. The day it fully supports it, I will be able to add a few extra specs in my applications.
Another technological limitation is the limited number of containers that implement Servlet 3.0 and EJB 3.1. Today, only GlassFish and Resin implement the Web Profile (and the full profile for GlassFish). But JSF 2.0 can run on Servlet 2.5 (i.e Tomcat 6.x).[/I]
[B]2. What Java EE 6 technologies are you using and why ?[/B]
[I]In fact, if the question was "What Java EE 6 technologies are you NOT using and why?" I would have answered Servlet 3.0 and EJB 3.1 because they need containers (even if EJB 3.1 has an embeddable container that goes with it) and as I said, there is still a lack of containers implementing them. The rest of Java EE 6 can be used on a per-specification basis. At my customers I use any piece of Java EE 6 that I can. Bean Validation 1.0 and JPA 2.0 are so easy and well integrated that I use them as much as I can. The integration between Bean Validation and JSF 2.0 is also very handy. JAX-RS is a fantastic RESTful web services API that you can use with Servlet 2.5 containers such as Tomcat 6.x. I'm not even talking about JMS, JAX-WS and JTA that I use on a day to day basis.[/I]
[B]3. What is your development and deployment environment?[/B]
[I]I am an IntelliJ Idea addict. I gave up trying to figure out how Eclipse tries to work and which plugins to install (sorry, it?s not called plugins now but OSGI bundles, the ones you start and stop at runtime? what a joke). Once in a while I use NetBeans, but the Java EE 6 support with Intellij is really amazing. And then, I really have two different kinds of usages: GlassFish, H2 and MySQL and at my customers it's more Tomact, WebLogic, Websphere (unfortunately) and Oracle. Even if I have lots of complaints about Maven, I use it everywhere so I can be IDE-agnostic when I need to build my projects.[/I]
[B]4. What previous versions of Java EE / J2EE have you used ? How has the migration to Java EE 6 benefited ?[/B]
[I]Being a former BEA employee from 1999 and 2001, I can say that I've used all versions of the Java EE platform (from J2EE 1.2). The early versions being a very painful experience. I did a lot of Entity Beans CMP and it was a real nightmare. I remember the very first EJBs when the deployment descriptor was serialized and then it became XML files. Migrating from Entity CMPs to JPA was not easy as you had to go to your customer and say "sorry, we lied to you, Entity Beans CMP are not great and guess what? you need to throw your code to the bin and start with a fresh JPA 1.0 domain model". Like everybody I moved to Struts, Hibernate and Spring. But I quickly realized that I wasn?t an XML fan and found Spring was becoming too complex and messy for my needs. Since Java EE 5 development on server side has been simplified with convention over configuration with containers doing most of the work. Migration and portability has improved, I often work with customers who develop Java EE 5 application on one application server and deploy it in another. Java EE 6 goes even further in terms of portability.[/I]
[B]5. Describe the benefits of Java EE 6 to you in 120 characters.[/B]
[I]Jigsaw puzzle, Modular, standard, less xml, easy, easy, have I said easy?[/I]
[B]6. Advice for anybody who is looking at Java EE 6 for their next project ?[/B]
[I]Well, first of all you should buy my book ;o) ([URL]http://apress.com/book/view/1430219548[/URL]) Java EE 6 is modular; don't see it as a blob. Take the bits and pieces that you need. Start with JPA 2.0 and Bean Validation, that's easy. If you can, add JSF 2.0 that will simplify configuration, resources management and component development. Take JAX-RS if you do RESTful applications. For injection, and many more, use Weld (the CDI implementation) that runs also on Tomcat. If you do Spring 3.x, think of using @Inject (unfortunately Spring doesn't implement CDI). If you then can use GlassFish or Resin, these are the two implementations ready to execute your EJBs 3.1 (JBoss 6 is on the way). Because Java EE 6 is so simple, don't over engineer your code: interfaces are not always needed; DAOs are not always needed either... KISS and refactor your code later if you really need it.
The final word is, add Java EE 6 specification to your project in an incremental way. When you can get rid of a proprietary framework and change it to a standard one, do so. You will avoid "vendor locking" (or "open source framework locking", as open source is different from open standard). And use design patterns when you really need them.[/I]
[B]7. What new features you'd like to see in Java EE 7 ?[/B]
[I]What I really miss in Java EE 6 is something similar to Spring Web Flow or Seam Page Flow. I hope that in Java EE 7 a new specification will come and standardize flow management (for JSF, of course, but something more general letting you manage different sorts of flows).
Batch processing is also something missing. Spring Batch is very good and defines well known principals such as jobs, steps and so one. With EJB 3.1 there is a new Timer Service (inspired from cron and as rich as Quartz). It's time to get a Batch processing specification that can be easily scheduled.
Security is also a difficult point. JAAS is too low level. Even if there are some improvements in the Servlet 3.0 API, there is still room to tight the platform together in terms of security.
Packaging could also be changed in Java EE 7. We talk a lot about OSGi these days. As a developer I found it too difficult, I would like the EE 7 platform to simplify the creation of bundles (OSGi or something different but compatible). I?m also hoping that Java SE 7 will become more modular. Modularity in Java SE 7 + OSGi packaging in EE 7 would be a great combination.
And I remember talking to Adam Bien about it, JMS hasn't changed for more than a decade, it should benefit from the novelties of the platform and get simpler.
In a word, I would like Java EE 7 to get richer (more specs), simpler (less code to write) and more integrated (security is one example).[/I]
Are you using, consulting, training, authoring books, etc in Java EE 6 ? Drop a comment on this blog and I'll line you up for the Q&A session :-)
The [URL="http://java.sun.com/javaee/technologies/"]Java EE 6 hub[/URL] is your key resource to learn all about the technology.
And you can always try all Java EE 6 features in [URL="http://glassfish.org/"]GlassFish[/URL].
Technorati: [URL="http://technorati.com/tags/javaee6"]javaee6[/URL] [URL="http://technorati.com/tags/community"]community[/URL] [URL="http://technorati.com/tags/feedback"]feedback[/URL] [URL="http://technorati.com/tags/antoniogoncalves"]antoniogoncalves[/URL] [URL="http://technorati.com/tags/glassfish"]glassfish[/URL] [URL="http://technorati.com/tags/v3"]v3[/URL]
[url=http://blogs.sun.com/arungupta/entry/qa_3_java_ee_6]Read More about [QA#3: Java EE 6: Jigsaw puzzle, Modular, standard, less xml, easy, easy - by Antonio Goncalves...[/url]


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There were 85 bookings at the San Joaquin County Jail in the 24 hours ending at 8 a.m. Sunday. At that time, there were 1,445 people held at the jail, which has an official capacity of 1,411. When the jail is full, some inmates may be released early.
DUI checkpoint: Officers conducted a DUI checkpoint on El Dorado Street between Weber Avenue and Market Street on Saturday night. No arrests were made out of 784 vehicles that passed through. Four people were evaluated for DUI but were found to be under the legal blood-alcohol limit of 0.08. Officers issued 31 citations and nine vehicles were impounded.
Vehicle shot: Three men were driving in a car on Stanislaus Street near Main Street at 10:38 p.m. Saturday when they heard multiple gunshots fired. Their car was struck by at least one bullet.
Assault with a deadly weapon: A Stockton man allegedly stabbed his son at his home on the 1900 block of Pawnee Way at 12:54 p.m. Saturday. Officers arrested Frank Ornelas, 53, on suspicion of assault with a deadly weapon after he stabbed his son and threatened him further with a machete. The son had reportedly intervened in a domestic dispute between Ornelas and his wife.
Attempted robbery: A 72-year-old man was working at his booth at the Flea Market at 2542 El Dorado St. when a customer attacked him and tried to steal money. The vendor told police a Latino man in his early 20s with long black hair in a ponytail inquired about an item at 2:30 p.m. As the item was being described, the customer grabbed the vendor and tried to pry money from his pocket. After a struggle, the customer failed to get any money and fled. He was last seen wearing a black shirt with burgundy stripes, jeans and black shoes.
The California Highway Patrol did not provide statistics for injuries, accidents or arrests for the 24 hours ending at 8 a.m. Sunday.
The Stockton Fire Department responded to 98 calls for service in the 24 hours ending at 8 a.m. Sunday, including six vehicle accidents, 69 medical calls and one structure fire.
Location, ST | website.com


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The Best (and Wildest) Dressed at the 2013 Emmys
At the Chrysalis Butterfly Ball, the actress looked romantic in a multi-textured, fluttery-sleeved daytime frock.
The starlet brought her cool girl thing to BAFTA's with a wide-brimmed hat, capris, and a jaunty white blazer. So Bianca-slash-Mick.
CFL's 5 Top Beauty Trends From Spring 2014 Fashion Week


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I search the forum and couldn't find how to set qcad cut file for engraving
I just done my first RC model airplane parts cut file with a laser engraver out of New Mexico. and they had no problems cutting it.
But for future projects I would like to have letters and numbers engrave on my model airplane parts. I hear some about adding a layer on to the cut file for the engraving of letter and number but want to check with the experts in this forum or someone who as done this.


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SEL's mission is to conduct systematic or taxonomic research on economically important insects and mites, to provide identifications to U.S. ports in support of the resolution of quarantine issues, and to fully enrich and enhance the United States National Insect Collection (Smithsonian Institution). SEL achieves these goals through many activities, including the discovery of new organisms in America's natural areas. These discoveries allow SEL to contribute to the quarantine of U.S. borders and our nation's food supply by providing tools that help differentiate between native and invasive species of insects and mites.
SEL's research and collection-based activities make a broad contribution to systematic studies being conducted worldwide, providing tissue samples for DNA analyses, genetic data to GenBank, and relevant collection-based information, to other scientists - specimens are the raw material for all ecological, environmental, molecular, biogeography, and revisionary/systematic studies.
Click on this link to learn more:
SEL and collections: a presentation at 2010


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UPDATE: "The Flash" Hasn't Cast Savitar, Says Berlanti
TV, Comic Books
Showing results 45-84 of 165
Courtesy of Image Comics, CBR presents an exclusive preview of "Chew" #33 by writer John Layman and artist Rob Guillory. Tony Chu takes on a load of seamen April 17.
Image Comics has released its complete July solicitations featuring images and solicitation info for "Satellite Sam," "Ghosted," "The Walking Dead," "Fatale" and many more!
French cartoonist Fred passes away. John Layman on "Chew" and writing 900th issue of "Detective Comics"! PictureBox announces new manga titles! Lucy Knisley, on "Relish" and her love of comics! Plus more!
The writer of "Chew" and "Detective Comics" recounts tales from his entire comics career as John Layman openly chews the fat with fans at WonderCon Anaheim.
Depending upon your taste for TV blood and violence, the "Hannibal" trailer will either whet your appetite for the NBC thriller, or turn your stomach. But what is it about (fictional) cannibals that we find so intriguing?
Before the next major "Chew" arc, John Layman returns to describe how a funeral in his and Rob Guillory's series leads to spontaneous combustion and the return of some old foes before this week's issue #32.
Image Comics has exclusively provided CBR with its complete June solicitations featuring images and solicitation info for "The Walking Dead," "Fatale," "Lazarus" and many more!
Image Comics has provided CBR with its complete May solicitations featuring covers and previews for JMS' "Ten Grand" #1, "The Bounce" #1, "The Dream Merchant" #1, "The Walking Dead" #110 and more!
New trailer for "Iron Man 3" hits! Benedict Cumberbatch discusses "Star Trek Into Darkness" research! New spoilers for "The Walking Dead!" Plus, Marve Phase Three rumors and more!
Sales of manga dip 1.5 percent in Japan! Scottish history, in graphic novel form! Kodansha Comics nabs "Sherlock Bones"! John Layman talks "Chew"! Sonny Liew on his Epigram Books work! Plus much more!
John Layman unexpectedly announced late Friday evening that the Showtime adaptation of his creator owned series with Image Comics, "Chew," has been cancelled.
Jennifer Cheng gives "Chew" #31 4 stars, saying writer John Layman and artist Rob Guillory's follow-up to the game-changing "Chew" #30 "has remarkable emotional depth without being depressing."
Courtesy of Image Comics, CBR presents an exclusive preview of "Chew" #31 by John Layman and Rob Guillory. Bite into the beginning of the second half of the series January 23.
"Chew" artist Rob Guillory promises the planned Showtime adaptation of the Image Comics series has "an awesome script" that, stylistically, is "about as close as you can get to something as weird as [the comic]."
Following purchases of Pixar, Marvel and Lucasfilm, Disney eyes cost-cutting measures! Another look at the Shooter Era of Marvel! Lemire on the end of "Sweet Tooth"! The waning of rage comics! Rob Guillory on "Chew"! More!
Augie De Blieck Jr. gives "Chew" #30 by John Layman and Rob Guillory 4 stars, calling the series' halfway point "a pivotal issue in the series, with plenty of hints being dropped for what's to come in the future."
This week, readers of John Layman and Rob Guillory's "Chew" discover a shocking turn in the series' midway point issue #30, as Layman explains to CBR what the gruesome issue means for the book's future.
Rob Guillory, artist and co-creator of "Chew," stepped up to the ROBOT ROULETTE table to reveal the worst job he ever had, "He-Man" and "ThunderCats'" influence on his career and more.
Image Comics has provided CBR with an exclusive preview of John Layman and Rob Guillory's "Chew" #30. The critically acclaimed title hits its halfway point and wedding bells are in the air on November 28!
While Agent Tony Chu remains out of commission, the rest of the cast of Image's hit "Chew" have things to answer for as writer John Layman prepares for the milestone 30th issue mid-way point of the series.
Image Comics has provided CBR with their complete February solicitations featuring covers and previews for "Chew," "Cyber Force," "It Girl & The Atomics," "Spawn" and many more.
Courtesy of Image, CBR presents an exclusive preview of "Chew #28 by John Layman & Rob Guillory. Take a bite out of Part 3 of "Space Cakes" on 9/12.
More on status of "Cerebus: High Society" negatives after fire! "Chew" and the rise of "foodie comics"! Brandon Graham on "Multiple Warheads" and manga influences! Plus more!
John Layman and Rob Guillory explained the origin of "Chew," their adventures in the world of television, casting choices and more at Fan Expo Canada.
John Layman spoke with CBR TV about his upcoming run writing Batman for "Detective Comics," the status of Showtime's "Chew" adaptation, working on more than on creator-owned title at a time and his dream DC Comics gig.
A rowdy crowd in San Diego enjoyed stories from behind the scenes of the hit Image Comics series "Chew" by writer John Layman and artist Rob Guillory at Comic-Con International.
Jonathan Ross treated Comic-Con International to a comics version of his British chat show featuring Robert Kirkman, John Layman and Ed Brubaker discussed writing comics, creator-owned properties and inspiration.
ROBOT 6 has the exclusive first look at Rob Guillory's Easter egg-filled tri-fold cover for "Chew" #30, which writer John Layman teases marks the halfway point for the popular Image series.
"Chew" co-creator John Layman spoke with CBR exclusively about his new gig writing "Detective Comics," his plans to focus on the detective aspect of the Dark Knight and working with Batman's infamous rogues gallery.
John Layman spoke with CBR about his and Rob Guillory's cybernetic luchador secret agent rooster-starring one-shot, "Chew: Secret Agent Poyo." Plus, an exclusive preview of the comic!
Courtesy of Image Comics, CBR presents exclusive advance looks at two of this week's new releases: John Layman and Rob Guillory's "Chew" #26 and "Witchblade" #156 by Tim Seeley, Diego Bernard and Fred Benes!
Image Comics has provided CBR with a look at their July solicitations, featuring solicit text and previews of "The Walking Dead," "Debris," "Revival," "Saga" and many more.
Image Comics has provided CBR with a look at their June solicitations, featuring solicit text and previews of "Spawn," "Planetoid," "Creator Owned Heroes," "The Red Diary" and more.
"Chew" writer John Layman is back on CBR to discuss the most recent, most brutal chapter of the "Major League Chew" arc, from Tony's captive torture to Colby's new Lion partner Buttercup and more.
Image Comics has provided CBR with an exclusive first look at May's solicitations, featuring solicit text and previews of "Mind the Gap," "Grim Leaper," "Epic Kill" and more.
John Layman returns to CBR to reveal the secrets of "Chew" from the prognosticating powers that impacted Tony Chu's family on through the current murderous arc of baseball hijinx and more.
Archives: All | Comic Books | TV/Film | Video Games | Web Comics


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- Signed by Fernando Torres!
- Currently Unavailable
Fernando Torres became the fourth most expensive soccer player in the world following his move to Chelsea during the 2011 transfer window. Now you can support Chelsea's new star striker with this official photo signed by Torres himself!
Lamentamos que todavia no hay descripción en español para este producto.


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Plano Bow Guard SE 44 Single Bow Case
The Plano® Bow Guard™ SE 44 Single Bow Case features a rigid design with more flexibility and storage options. 3 padlock tabs for added security. Plenty of room for accessories. Includes newly designed Sure-Loc™ arrow retainers that hold 12 arrows and fully-loaded quiver. Lockable and airline approved. Inner dimensions: 43.09'' x 15.3'' x 8.0''. Outer dimensions: 44.6'' x 20.4'' x 8.7''. Weight: 9.8 lbs.
Quiver mounting hardware not included and must be purchased separately. If you have a Kwikee quiver: please find your mounting hardware through item search for number 540213.
Outdoor Answers
Get help about this item from fellow customers.
Ask your questions. Share your answers.
Will a Matthews Q2XL fit in it?
Will a pse mach6 fit in this case?
Will this case fit a compound bow?
Where can I find the accessories for this case?
Go to your local craft store and buy two 12-inch pieces of velcro. Then secure them to your case with the pre-molded screw holes. There you have a great quiver mount for less than $3.00 and you can pick the color.
Even though I made one, I just leave my quiver attached to my bow now.
Need Help? 7 days a week: 7am to 10pm CT or call 1.800.227.7776 anytime


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My brother and i have used ps3 media server for a while.
The streaming has worked perfectly with 1080p material.. ( I have Q6600 and 8GB ram) (Brother has 4800+ 2gb ram) Gigabit network.
But now, my brother started to get stuttering with all his movies.. .. strange...
So i had to test my PS3... and WTF! it also got this stuttering issuies.. WTF!
I have google a little... and it seems that new firmware har broke the streaming?
I hope SONY will fix this...
anyone else with this problem?


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Tuesday's letters: Flat Rock park
Published: Tuesday, February 26, 2013 at 4:30 a.m.
Last Modified: Monday, February 25, 2013 at 5:04 p.m.
To the editor: Id like to respond to Chip Worrells Feb. 15 column.
In reply to his letter to the citizenry in Flat Rock Village, he said we could have had a free park where the Highland Lake Golf Course now stands in return for letting the kids play soccer games there for 20-25 days (not and nights) a year. What did Mr. Worrell and the soccer association plan to do with this park of nine soccer fields the other 340 days (and nights) in the year?
Maybe he can now understand why I and others worked for more than seven years to get Staton Woods annexed into the Village of Flat Rock!
W.B. Owens Jr.
Border security
To the editor: A letter in Sundays Times-News claimed that Congress reneged on a Ronald Reagan-era compromise with the president on immigration reform because the executive branch failed to follow through and enforce border security. A story on page A4 of the same issue said that since 1994, the second year of the George H.W. Bush era, security on the Mexican border has improved exponentially over that during Reagans presidency.
The letter said that President Reagan compromised conservative principles based on promises of future action from Congress, as if its the duty of Congress to carry out laws created by the president exactly the opposite of what the Constitution requires. If the conservative principle here is border security, though, four presidencies since Reagan have drastically increased border security. And the reform law at issue was sponsored by Republican Sen. Alan Simpson, not by a Tip ONeill-led House of Representatives.
A new reform bill certainly is needed, partly to correct some unintended consequences of the Reagan-era bill. But any mythical failure to enforce the earlier reform would not have been a failure of two Republican and two Democrat presidents. Nor can it rationalize unwillingness for opposing ideologies to compromise for the good of the nation.
David M. Hudelson
Horse Shoe
Worthy words
To the editor: As we go about our day, these thoughts might be very meaningful to you.
I am certain that after the dust of centuries has passed over our cities, we, too, will be remembered not for our victories or defeats in battle or in politics, but for our contribution to the human spirit. John F. Kennedy.
The test of progress is not whether we add more to the abundance of those who have much: it is whether we provide enough for those who have little. Franklin D. Roosevelt.
What you do makes a difference. And you have to decide what kind of difference you want to make. Jane Goodall.
There can be no keener revelation of a societys soul than the way it treats its children. Nelson Mandela.
The problems that exist in the world today cannot be solved by the level of thinking that created them. Albert Einstein.
Only after the last tree has been cut down/only after the last river has been poisoned/only after the last fish has been caught/only then will you find money cannot be eaten. Cree Prophecy.
Judy Berman
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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1.2-8 Police Testimony
Revised to December 1, 2007
Police will be testifying in this case. You must determine the credibility of police officials in the same way and by the same standards as you would evaluate the testimony of any other witness. The testimony of a police official is entitled to no special or exclusive weight merely because it comes from a police official. You should recall (his/her) demeanor on the stand and manner of testifying, and weigh and balance it just as carefully as you would the testimony of any other witness. You should neither believe nor disbelieve the testimony of a police official just because (he/she) is a police official.


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The Oak Ridge High School swim team outscored Cleveland High School at its second meet of the season 198-117 to record its first win. Nine swimmers, Lois Johnson, Kathleen O'Neil, Sarah Kate Rogers, Elisabeth Gallmeier, Ryan Mihealsick, Gaibo Zhang, David O'Neil, Loki Hondorf and Megan Kelly, won two or more races for the Wildcats.
Five ORHS swimmers posted their personal best times: Gallmeier in the 200 freestyle (2:06.80); Rogers in the 200 individual medley (2:43.42); Zhang in the 100 butterfly (59.27); Hondorf in the 500 freestyle (5:00.67); and Patrick Williams in the 200 freestyle (55.95).
In the girls 200 individual medley, Lady Wildcat swimmers swept the medal stand as Rogers, Katherine Zhang and Hannah Craig took first, second and third.
"The girls won some races, which is great, and I think the team as a whole is coming together really well," said assistant coach Betsy Hondorf.
The next meet is at 6:30 p.m. tonight against Maryville. The event is free and open to the public at the Oak Ridge Civic Center pool.
Location, ST | website.com


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Norma Winkelman, 89, formerly of Milan and Montevideo, died Thursday, Sept. 27, 2012, at Guardian Angels Care Center in Elk River. Funeral services were held at 1:30 p.m., Tuesday, Oct. 2, at Kviteseid Lutheran Church with the Rev. Bruce Berg officiating. Burial was at the church cemetery.
Anderson-TeBeest Funeral Home, of Montevideo, was in charge of the funeral arrangements. (Online guest book at www.andersonfuneralmontevideo.com)
Location, ST | website.com


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Road agent's alleged misbehavior at heart of harassment suit against Barnstead
BARNSTEAD — After a three-year investigation, the N.H. Commission on Human Rights has determined a there is probable cause for a former highway department foreman to sue the town and its elected road agent for sexual harassment and retaliation.
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SAN JOSE -- Networking giant Cisco Systems (CSCO) announced Wednesday that it has agreed to pay $475 million for Intucell, an Israeli company that produces networking software that allows wireless carriers to handle the increasing traffic on their systems.
With customers connecting more powerful smartphones and tablets to cellular networks, carriers face a growing burden that Intucell's self-optimizing network, or SON, software can help them manage, Cisco said in Wednesday's announcement.
"The mobile network of the future must be able to scale intelligently to address growing and often unpredictable traffic patterns, while also enabling carriers to generate incremental revenue streams," Kelly Ahuja, senior vice president and general manager of Cisco's Service Provider Mobility Group, said in the news release.
Intucell was founded in 2008 by CEO Rani Wellingstein and Ido Susan, who is currently vice president of products.
The deal is also a big victory for venture capital firm Bessemer Venture Partners, which was the sole investor in Intucell's 2011 Series A funding round. Bessemer put $6 million into the company in exchange for a nearly 50 percent ownership stake, according to sources familiar with the investment, then helped the company land a $50 million contract with AT&T that spurred massive growth.
Cisco will pay the $475 million in cash as well as incentives to Intucell employees to stick around and work for the San Jose company. Cisco expects the deal to close in the current quarter, its fiscal third quarter.
The Intucell acquisition may be just a start for Cisco as well, as CEO John Chambers said late in 2012 that the company's security-software leader, Chris Young, has a "blank check" to boost the company's security offerings, according to a Reuters report released last week. That report also noted that Cisco has acquired almost 160 companies in the past 20 years.
Cisco stock did not receive a bump on Wall Street from Wednesday's news -- the stock fell 1.2 percent to $20.62. The company is scheduled to release earnings results from its fiscal second quarter Feb. 13.
Staff writer Peter Delevett contributed to this report. Contact Jeremy C. Owens at 408-920-5876; follow him at Twitter.com/mercbizbreak.


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Charlotte Armatha (Kipe) Poole, 89, a resident of Ravenwood Village Nursing Home, Hagerstown, Md., and formerly of Cherry Lane, Cascade, Md., passed away Monday morning at sunrise, Jan. 28, 2013, in the nursing home. Born Aug. 17, 1923, in her family home on Cherry Lane, she was the daughter of the late Carl and Bertie (Harbaugh) Kipe. Mrs. Charlotte Poole attended the Frederick School for the Deaf, Frederick, Md., from 1938 until the spring of 1941. She and her husband, the late Mr. Charles A. Poole Jr., were married Dec. 13, 1941, in Baltimore, Md. He passed away March 29, 2012. Mrs. Poole worked in Waynesboro, Pa., during the World War II; after that she focused all her time on being a great homemaker and fantastic mother to her three children. Mrs. Poole was a member of Germantown Church of God, Cascade, Md., where she was a Sunday school teacher in the 1950s, '60s and '70s. She also was a member of Order of Eastern Star. Mrs. Poole is survived by two sons, Charles A. "Charlie" Poole III and his wife Linda of Warfordsburg, Pa., and Mark R. "Randy" Poole and his wife Gloria of Slidell, La.; five grandchildren, Charles A. Poole IV, Sandra (Poole) Sedmeyer, Shannan Poole, Bertie (Poole) Chinn, and Danielle Poole; five great-grandchildren; and two great-great-grandchildren. In addition to her parents and husband, she was preceded in death by her daughter, Bertie S. (Poole) Embly. Services will be held at 10 a.m. Tuesday, Feb. 5, 2013, in Germantown Church of God, 16924 Raven Rock Road, Cascade, Md., with Pastor Mark A. Hosler officiating. Burial will be in Bethel Church Cemetery, Cascade. Memorial contributions may be made to Germantown Church of God, 16924 Raven Rock Road, Cascade, Md. 21719. Arrangements are by Grove-Bowersox Funeral Home, Waynesboro. Online condolences may be expressed at: www.bowersoxfuneralhomes.com
Location, ST | website.com


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The Hot Springs National Park Quarter
The Hot Springs National Park quarter is the first of 2010 and the first overall in the America the Beautiful Quarters® Program. Hot Springs National Park, destination of the Dunbar-Hunter Expedition sent by President Thomas Jefferson in 1804, features prehistoric American Indian quarries. A bustling town grew up around the hot springs to provide health services. Hot Springs was first established as a national site on April 20, 1832 (4 Stat. 505), to conserve the water from the 47 springs that emerge from Hot Springs Mountain and to ensure that water was made available for drinking and therapy.
The quarter's reverse (tails side) image depicts the façade of the Hot Springs National Park headquarters building with a thermal fountain in the foreground. The headquarters was built in the Spanish colonial revival style and completed in 1936. The National Park Service emblem is featured to the right of the door. Inscriptions are HOT SPRINGS, ARKANSAS, 2010 and E PLURIBUS UNUM. Design candidates were developed in consultation with representatives of Hot Springs National Park.
Additional Links
America the Beautiful Quarters® Program products – Browse our Online Store for all the latest America the Beautiful Quarters Program products. From annual sets to bags and rolls to our America the Beautiful subscription program, we have everything you need.


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Elan spins off drug discovery
14.08.2012 - The Irish pharma company Elan Corporation plc is to spin off its drug discovery business.
The drug maker will spin off its drug discovery business unit Neotope Bioscience with about 80 employees and US$120m to US$130m in start-up capital from Elan. The remaining core of Elan would employ 90-110 people and would be profitable immediately. It will consist of three main assets: the Multiple Sclerosis drug Tysabri, which had sales of US$1.5 bn last year and is expected to grow by 15 percent annually over the next four years, as well as the small molecule ELND005, a beta amyloid anti-aggregation agent for neuropsychatric indications. Elan will retain its interest in Janssen AI, which in partnership with Pfizer is developing Elan's Alzheimer's Immunotherapy Portfolio.
The announcement came only days after Pfizer and Johnson & Johnson pulled the plug on the Phase III development of the Alzheimer drug Bapineuzumab. The move fueled speculation that Elan strives to make itself more attractive as a buyout target. Elan's CEO Kelly Martin did nothing to mitigate takeover fantasies: "What other companies want to do with regard to looking at our assets or any other assets is up to them - we're all public companies," he said. "There are no obstructions that we have put in place or that we seek to put in place." Analysts at Jefferies quickly concluded that a buyout certainly appears to be the intended goal here. "Jefferies thinks many will view Elan's announcement as the first step towards making the company more appealing for a takeover by Biogen," the group concluded.
Elan has partnered its drug Tysabri with Biogen Idec, why some analysts believe Biogen may use the opportunity to buy Elan, in a similar way that GlaxoSmithKline recently bought Human Genome Sciences to get full control of lupus drug Benlysta.http://www.european-biotechnology-news.com/news/news/2012-03/elan-spins-off-drug-discovery.html


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Mini Crystal Charm Fillable Vial SQ Clear 15mm 1/2"
Our Price: $2.99
Retail Price: $4.99
You save 40%
Item SKU: 1203Z
Ask a question about this product
Why you'll LOVE this item:1 mini memory crystal vial, glass bottle, message in a bottle, secret message or wish keeper. 15mm each. (approx. 5/8" tall). Metal screw top with 1.5mm hole. These cuties are just right for a grain of rice (maybe from your wedding day with your initials?), sand from your favorite beach, a drop of perfume or a mini note. Sky's the limit. Attaches to cord or chain of your choice (sold separately) with a simple jump ring (included).


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January 27, 2013
DL Deadrin Senat of Immokalee, FL made his official visit to NC State over the weekend. Reached as he was boarding his plane, Senat said he did not commit to State and asked to be contacted later. He was favoring USC going into the visit. Gamecock head coach Steve Spurrier made his in home visit with Senat last week.Tweet
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Texas is poised to join Saudi Arabia as a supplier of oil to California as the mounting glut of crude on the U.S. Gulf Coast makes the trade profitable.
Kinder Morgan Energy Partners, the pipeline operator that's buying U.S. oil tankers, said it's in talks to ship Texas crude to California through the Panama Canal. The 4,500-mile voyage would cost about $10 a barrel, broker Poten & Partners estimates, making Texas crude competitive with imports traveling 11,400 miles from Saudi Arabia, the West Coast's largest supplier, data compiled by Bloomberg show.
Until now, a U.S. law that makes domestic shipping more expensive left Californians buying oil from the Middle East instead. If a shortage of qualifying ships can be overcome, Texas crude will become affordable on the West Coast as the highest domestic output in a quarter century creates a surplus of light oil and drives down prices.
"The West Coast has been short crude over the last couple of decades with Alaska North Slope and California oil production down," said Andy Lipow, president of Lipow Oil Associates in Houston. "Getting more crude from other areas of North America into the West is going to help refiners, and if you have a big glut of light, sweet crude on the Gulf Coast, tankers will load."
The posted price for light crude from Texas's Eagle Ford shale formation has climbed 0.5 percent in the past year to $93.75 a barrel, according to the marketing division of Plains All American Pipeline. That compares with $99.73 for light Saudi Arabian crude and $97.23 for the equivalent Iraqi grade, plus $3.38 for shipping to the U.S. West Coast, according to data compiled by Bloomberg.
Shipping between U.S. ports costs more than international voyages in part because a 94-year-old law called the Jones Act requires domestic cargo to travel on U.S.-built, owned and crewed vessels. A qualifying tanker commands record rates close to $100,000 a day, according to MJLF & Associates, a broker. That's about 10 times more than a tanker of the same size that doesn't meet the requirements, according to data from Clarkson, the world's largest shipbroker.
Using a Jones Act tanker may still beat the cost of transporting oil by train, said Court Smith, head of research at Poten in New York. Rail costs to Washington state from North Dakota's Bakken field run at about $9 a barrel, while Alberta, Canada, to California costs $13 to $15, Valero Energy, the world's largest independent refiner, said in a Nov. 13 presentation.
"Increasingly we're talking to people, no firm commitments, who think that they will use Jones Act tankers, that have to be Jones Act, to take production out of Texas and move it through the canal and back up to California," Richard Kinder, the company's chairman and chief executive officer, said on a Jan. 15 conference call. Richard Wheatley, a spokesman, declined to elaborate.
The oceangoing Jones Act fleet of about 85 ships is fully booked, with no tankers available for one-time cargoes, said Pat Calahan, a broker and project consultant at MJLF in Stamford, Conn. The ships Kinder Morgan is buying from American Petroleum Tankers are all booked for several years on long-term contracts, according to a Dec. 23 company statement.
"There needs to be more length built into the Jones Act fleet before the industry takes a look at shipping to the West Coast," Glenn Simpson, general manager of crude and international supply at Phillips 66, said Jan. 22 during a conference in Houston. Phillips 66 runs three refineries in California and Washington state that can process a combined 315,000 barrels a day. The company has used Jones Act tankers to send Eagle Ford oil to its 238,000-barrel-a-day Bayway Refinery in New Jersey.
Kinder Morgan has tried to move Texas oil to California before. The company shelved plans in May to build a pipeline that would have carried 277,000 barrels a day from west Texas' Permian Basin to California's refiners by late 2016. Citing lack of customer interest for the pipeline, Kinder Morgan said at the time that it would focus on rail projects instead.
There are no pipelines linking the Gulf and California. The last time a ship carried crude between the Gulf and West Coast was in August 2012, Energy Department data through October 2013 shows.
In the past six months, two U.S.-flagged tankers crossed the Panama Canal. Chevron's California Voyager left Freeport, Texas, on Jan. 9 and was moored at the company's Richmond refinery in the Bay Area, ship-tracking data compiled by Bloomberg show. The SR American Progress, a Jones Act tanker owned by Exxon Mobil's SeaRiver Maritime, left Los Angeles on Jan. 5 and is anchored near Beaumont, Texas, signals show.
Spokesmen for Chevron and SeaRiver declined to comment.
The West Coast imports about 1.25 million barrels a day, with 24 percent coming from Saudi Arabia, according to October data compiled by the Energy Information Administration, the Energy Department's statistical arm. Ecuador supplies 16 percent, with another 15 percent from Canada and 13 percent from Iraq, data show.
California's daily output dropped from as much as 1.1 million barrels in 1986 to 547,000 barrels in October, Energy Department data show. Alaskan production slumped to 521,000 barrels a day from more than 2 million barrels a day in 1988. The state's supplies are poised to rebound as the repeal of a production tax triggers investments that may boost output by at least 90,000 barrels a day within four years.
The West Coast's reliance on imports contrasts with the country as a whole, which is meeting the largest share of its own energy needs since 1986, Energy Department data show. Nationwide production topped 8 million barrels a day in November and rose to the highest since 1988 as hydraulic fracturing and horizontal drilling unlock resources in shale rocks deep underground.
Because West Coast fuel producers can't get that oil, their refining margins of $12.35 a barrel are lower than the $13.36 on the Gulf Coast, data compiled by Bloomberg show. A gallon of regular gasoline costs $3.486 on the West Coast and $3.092 on the Gulf Coast, according to the Energy Department.
Valero, which runs refineries in the San Francisco and Los Angeles areas, doesn't ship crude through the Panama Canal to its California plants, "although we would certainly consider it if it made economic sense," Bill Day, a spokesman at the company's headquarters in San Antonio, said by email.
The company is planning a complex at the 170,000-barrel-a-day Benicia refinery that would allow the plant to unload as much as 70,000 barrels of crude a day from rail cars. The project is pending city approval.


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Grant Bosse: Shaheen is willing to ignore rules she doesn't like
Grant Bosse is editor of New Hampshire Watchdog, an independent news site dedicated to New Hampshire public policy. He is a senior fellow at the Josiah Bartlett Center for Public Policy.
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McCONNELLSBURG — Mitchell Vincent Knipp, 21, of McConnellsburg was charged by Pennsylvania State Police after a 1-year-old McConnellsburg boy in his care from Dec. 1 to Jan. 12 had multiple fractured bones.
Knipp was charged with aggravated assault, simple assault, reckless endangerment and endangering the welfare of children.
Location, ST | website.com


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South Carolina law enforcement is looking for a 'person of interest' in an Orangeburg murder case.
The person they're looking for, Willie Bell, Jr., was in Augusta this past weekend.
Investigators seized his car Tuesday at the Adams Super Inn on Gordon Highway, but never found Bell.
They say the car came from a house that caught fire in Holly Hill, South Carolina.
Last Thursday firefighters had finished extinguishing the flames that destroyed a Holly Hill house, and they found a body.
Evidence showed that the victim, 78-year-old Annie Bell, didn't die in the flames, but was killed before the fire.
Bell's grandson, Willie Bell, Jr., also lived at this home, but disappeared along with his grandmother's car.
Orangeburg County deputies call Bell a "person of interest" and want to talk with him, but can't find him.
Information led the Orangeburg County investigators to Augusta, off Gordon Highway. They found Bell's car at the Adams Super Inn.
Kareem Taylor lives at the inn and got to know Bell.
"Met the guy Sunday," Taylor says. "He had a red car. He was trying to sell, so I decided to buy the car from him. I decided to buy the car; I didn't know there was a lot of history behind it."
Taylor bought Bell's grandmother's 1998 Ford for $1500.
Bell told Taylor that to get the car title they had to drive to Orangeburg and get it from his grandmother.
"I rode up there with him to get the title, but she never appeared," says Taylor.
Shortly after that, Taylor got a phone call.
"Some of the detectives in my family had seen the news and they told me, 'You're in the car with a killer.' Oh my god," Taylor says.
Horace Rainey, who also lives at Super Inn, saw Bell on the news, and recognized him when Bell visited his room.
"I looked at him. I said, 'Your name is William Bell, Jr.' He said, 'How do you know that?' I said, 'I see you on TV'," says Rainey.
Investigators aren't sure why Bell came to Augusta.
They do know he has connections somewhere in Georgia.
Kareem Taylor says he left Bell in Orangeburg and believes he stayed there, but investigators say Bell could be anywhere.
If you know where Willie Bell, Jr. is, call CrimeStoppers at 1-888-559-TIPS, or go to http://www.midlandscrimestoppers.com/ and submit a tip.


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Over the years I've tried to cultivate the reputation of a fan who follows the rules. If the band says not to do something, I try not to do it. However this hasn't always been the case. In my early days I was a bit of a rebel. If you need proof of my evil ways, you only need to look at this night, the night that I snuck into a Phish show.
In my defense, it wasn't completely my fault. When I was driving the 120 miles from Bard to Amherst (ah for the days where that seemed to be an incredibly long distance to drive to see a band!) I wondered about ticket availability. Even back then I was pretty paranoid about things going wrong, but I wasn't too worried. I mean, who ever heard of a Phish show selling out?
I have seen many tough tickets over the years. Many of the New Years' tickets have been difficult, especially the return from Hiatus show. I nearly got shut out of a show in the Capitol Theatre. Tickets for the Halloween concerts were tough to come by. Nothing though - not even 3/6/09 - was worse than this night. I could always compare later ticket problems to earlier ones. Nothing prepared me for my first one. Moreover, this was just a student event. There weren't people who had an extras that they were hoping to trade for the next night or something. Anyone who had a friend bail just had to ask another dorm mate.
So there I was, shut out of a Phish show. Admittedly, this wasn't the biggest tragedy ever. This show was held inside of some sort of student center building. The concert was just in a big room inside it. Since people were going in and out of it all night, they kept the doors open. The difference between being inside the show and outside the show was pretty technical. There was a line on the floor that marked the difference.
Even though I could hear the show just fine from "outside", I wanted to actually see the band. My salvation here was twofold. While dancing around, someone inside the room got my attention and handed me a ticket stub. Believing (mistakenly) that you needed both the stub and the hand stamp to get back in, I turned to a security guard. By coincidence a friend of mine from Bard was one of the people responsible for preventing people from getting in. She took her job seriously. So seriously did she take it that she grabbed a magic marker and drew something on my left hand that vaguely resembled the stamp. During "My Sweet One" I walked around the room. I showed the stub and fake stamp to the person who was checking. While doing that I got the real stamp on my right hand. My Jedi Mind trick worked! Ironically, I spent quite a bit of the rest of the show "outside" to get some space, but it was okay then, for I was no longer shut out.
So I sacrificed all of my moral standards in order to see this show. Was it any good? Actually, yes. This was probably the best Phish show I saw in the entire year. Six of the new songs for this tour were played ("Stash", "Landlady", "Asse Festival", "Destiny", "Buried Alive", and "Magilla") and they were all really good. "Stash" especially stuck in my head. This was my first time hearing it, so I named it after what I thought the repeated line at the end was, "Maybe So My Love." I was only off by two words.
Two things make this show stand out over most 1990 concerts. The first is the repeated "Chariots of Fire" motif. Everyone loves the "Wipeout" and "Moby Dick" sets, right? Well this is the same idea only much earlier. The recurrence helps give the night a connected feel.
The bigger highlight though is the "Bowie". This is a serious jam.
Most Bowies from this period were twelve to fourteen minutes; this one clocks in at nearly twenty. From the long intro (be sure to notice the early Secret Language) to the extended jam, this is a rare case in this time period of Phish taking a song out a bit.
A copy of this show (along with 9/20 and 9/21) has started to circulate on Bit Torrent. I highly recommend this show, especially if you have little from this time period. You get to hear the original slow-down ending of "Tweezer", an early version of "Stash", and get a great "David Bowie" as a bonus. How could you go wrong?


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SAN JOSE -- The Sharks let two points slip away against a non-playoff team Thursday night. Now San Jose may need to win the rest of its regular season games just to stay in first place in the Pacific Division.
The Sharks' normally solid penalty kill allowed two goals, including the eventual game-winner with 3:36 left in the third period, in a 4-3 loss to the sputtering Winnipeg Jets.
Just 27 seconds after Logan Couture took a delay-of-game penalty for clearing the puck over the glass in his own end, Tobias Enstrom scored for Winnipeg, which is now tied for 11th place in the Western Conference.
Since the Olympic break, the Sharks have let valuable points slip away against teams not in the playoff picture -- gaining just six points combined in games against Buffalo, Carolina, the New York Islanders, Florida, Calgary and Edmonton, and now Winnipeg.
"You want to be consistent, no matter who you play. We've let some teams that are not as good in the standings beat us and take points away, for whatever reason," Sharks captain Joe Thornton said.
The Sharks have 103 points and remain two points ahead of Anaheim for first place in the Pacific but have now played 75 games, three more than the Ducks. Los Angeles has played 74 games and is in third place with 92 points.
San Jose has seven regular season games left, starting with Saturday's game at Colorado.
"We have to win them all," Sharks coach Todd McLellan said. "I don't anticipate L.A. or Anaheim losing any games, so you have to win them all, and that's what the goal is. We've got to come in and perform well. I like that there's that pressure on us right to perform. It should keep us honest."
An eventful start to the second period saw the Sharks give up two straight goals -- including one that goalie Antti Niemi wanted to have back.
Blake Wheeler skated around Sharks defenseman Marc—Edouard Vlasic, and his shot from a bad angle somehow got past Niemi to tie the score at 2-2 less than two minutes into the second period.
Niemi had no chance on the Jets' third goal. Wheeler, on a Winnipeg power play, found an open Dustin Byfuglien with a cross-ice pass, and Byfuglien's one-timer gave the Jets' a 3-2 lead 9:32 into the second.
Couture, who was hurt in Monday's game in Calgary and missed Tuesday's game in Edmonton with a cut on his lower leg, had the puck find him again in the second period. This time, it was for his 20th goal of the year, as James Sheppard's shot from just above the circle went off Couture and behind Jets goalie Al Montoya with 8:37 left in the second.
Couture's penalty came with 10 seconds left on Brad Stuart's holding infraction and was too much to overcome even though San Jose is seventh in the league with a 86.5 penalty kill percentage.
"I tried to backhand it down, and it kind of flipped up on me at the last second," Couture said. "Unlucky. I'm not a big fan of that rule, never have been. But it's there, and it cost us tonight."
Burish had surgery Wednesday to insert two pins into his left hand, which was injured Tuesday in Edmonton when he blocked a shot by Oilers defenseman Jeff Petry at 14:05 of the second period. After the blocked shot, Burish skated directly to the Sharks dressing room, clutching his left hand and in obvious pain.
Burish missed the first four months of the season recovering from back surgery after he was hurt in a preseason game against the Vancouver Canucks. He returned to his fourth-line role Feb. 7 and had no points in the 14 games he played.
For more on the Sharks, see the Working the Corners blog at blogs.mercurynews.com/sharks. Follow Curtis Pashelka on Twitter at twitter.com/CurtisPashelka.
Saturday's game
Sharks (47-19-9) at Colorado (46-21-6), noon, CSNCA
Online extra
Scan this code with a smartphone to view a Sharks photo gallery or go to http://photos.mercurynews.com.


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Tunisia's Fight for Democracy
En route to a meeting with President Obama in early April, the Prime Minister of Tunisia stopped by Columbia Business School to address a standing-room-only crowd. Jet-lagged but brimming with a kind of determined optimism, Mehdi Jomaa declared, "We don't speak of Tunisia as being part of the Arab Spring. We think of our country as on the road to democracy."
In the three years since a produce vendor from the small city of Sidi Bouzid set himself afire in protest — igniting a wave of dissent not just in Tunisia but throughout the Arab world — the country's citizens have proven unwilling to settle for less than democracy. "The revolution was leaderless," Jomaa said. "The aim was not fully political, but encompassed the right to jobs, the rights of freedom."
Jomaa, whose transition government took office on January 29, promised elections by the end of 2014. The previous Parliament gave the Prime Minister a running start by ratifying a new constitution in December. Since then, Jomaa has laid the groundwork for reforms through talks with various political, financial, and educational groups. He has wooed investors in friendly countries such as France and the United States ("Did you know Tunisia was among the first countries to recognize the United States as its own country in 1799?" he told the Columbia Business School audience.) And Jomaa is gnawing at a state budget that ballooned under the previous government, which increased staff in an attempt to boost employment.
But most importantly, the current administration has stabilized the country. "The best thing we can do for democracy is to restore the authority of the state, the authority of law, and the authority of human rights," Jomaa said. "It's safer each day in Tunisia than it was the day before."
A Brief History of Tunisian Revolution
Tunisia's transition from brutal dictatorship to self-rule has been marked by surges and pullbacks, public outcry and acrimony, shifting allegiances and violence. The revolution began in late 2010, when a policewoman confiscated the produce cart of Mohamed Bouazizi, piling physical and verbal abuse onto the 26-year-old, who was the sole wage-earner for his eight-member family. Further humiliated when he was denied the opportunity to pay his 10-dinar fine (roughly equivalent to a day's wages), Bouazizi set himself afire outside police headquarters. Peaceful marches the next day protesting the economic and political system that led to Bouazizi's death quickly turned to riots when the police responded with force.
On January 14, less than a month after the incident, President Zine el Abidine Ben Ali fled Tunisia after 24 years of rule. The Constitutional Court approved a caretaker government, but street rallies escalated, with protestors angry that key members had been part of Ben Ali's Constitutional Democratic Rally (RCD) party. Several non-RCD ministers resigned. Two weeks later, the acting Prime Minister appointed a new government made up entirely of non-RCD members other than himself, promising elections within six months. As protests continued, he, too, resigned a month later.
Elections were held in October 2011. The Islamic Ennahda Party, which had been banned under the Ben Ali reign, took a plurality of seats, but the country remained restive. The party had supported democracy and outreach to the West, but critics worried that connections to the Muslim Brotherhood and more militant organizations would threaten Tunisia's moderate way of life.
Two assassinations of Ennahda critics threw Tunisians again into street riots and protests: Chokri Belaid, leader of the rival Democratic Patriots' Movement, was killed in February 2013, followed by the July 2013 murder of Mohamed Brahmi, who led the People's Movement. Both homicides were traced to the same gun, with the assassin believed to be a radical Islamist who had been implicated in weapons smuggling from Libya. His organization, Ansar al-Sharia, has been listed as a terrorist group, accused of storming the US embassy and attacks on art exhibits, establishments serving alcohol, a television station that aired the movie Persepolis (because it depicted God), and on shrines it considered un-Islamic.
As calls mounted for the resignation of the Ennahda government, rallies grew even larger and more frequent and general strikes closed cities and industries. When 42 members of the 217-seat constituent assembly resigned, the Parliament unraveled. Last October, Prime Minister Ali Laarayedh announced that the government would disband, but only after the assembly passed a new constitution and set up the groundwork for a new election.
In the next months, as protests continued, members from 21 parties hammered out details in sometimes contentious debate. In the end, though, the assembly adopted a 146-article constitution by a vote of 200 to 12. On Dec. 13, 2013, Mehdi Jomaa, who was serving as Minister of Industry, was elected acting prime minister.
"A Moderate People"
Despite the rancor, Jomaa insisted he was not surprised at the compromises, noting that the new constitution celebrates universal rights, equality of genders, and freedom of worship. "By nature," he said, "Tunisians are a moderate people. In 1846, Tunisia was the first country to abolish slavery. In 1878, we adopted our first constitution. In 1956, Tunisia legalized equality between men and women."
Jomaa, a 52-year-old engineer who lived in France for much of his career, appeared reluctant to take on too much as part of his caretaker role, saying "we won't make many reforms." However he said that a main priority involves creating a climate for prosperity. Noting that unemployment was a main driver of the revolution, he said the economy has only gotten worse in recent years. "Before the revolution Tunisia was growing at about 5 percent a year," Jomaa said. "Since then, the economy has only been growing at a two- to three-percent pace. Instability is not a good climate for creating jobs. The economy is a price you have to pay for revolution."
Pointing out that the produce vendor's home town of Sidi Bouzid is located about 200 miles from Tunis, Jomaa also acknowledged the inequality between the inland regions of Tunisia and the coast.
Still, Jomaa insisted, "Tunisia is a land for investors," noting that the majority of foreign companies that had a pre-revolution presence in the country remain. Because three cultures intersect in Tunisia, he said, geography is a big draw. "More than 80 percent of our trade is with Europe. We're a part of the Middle East. And we are in Africa, where the future lies." In addition to the competitiveness of labor, Jormaa said, "one of our best resources is education," noting that Tunisia's standard of education is on par with Europe's.
Audience member and Columbia professor Joseph Stiglitz wrapped up the evening by declaring that one of Jomaa's biggest duties involve restoring hope to a country that's been wracked by inequality and violence. "Mr. Jomaa has a huge, heavy responsibility," he said. "Failure is not a choice."


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medicineman wrote: I know I'm not terribly concened about H1N1, nor am I particular keen on what I feel like MUST be an under-tested vaccine. The only thing I see about this whole H1N1 situation as legitimate is as like a dry-run for an actual, worrisome global pandemic.
Inedible Condiment wrote: I'ma get it because I work at a hospital.
MP3D wrote: work is "making" you get it? forced immunization? where do you work? the vaccine from what i understand only protects from one form of H1N1, not the many mutated strands of it. Do you really want to put mercury into your body?
mancabbage wrote: 99.999% sure i had swine flu already, I was ill as hell for about three days then had a cough i couldn't shake for about a month, at the time i had got myself wrecked the day before it all started so assumed it was part of a bad hangover, a bunch of people i know have had it aswell, not much to worry about really


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Drug delivery technologies have the potential to enable drug candidates with poor pharmaceutical or biopharmaceutical properties, both for macromolecule and traditional compounds. While there have been many success stories to date, the future offers even more promise. In this article, the author surveys the top ten areas in drug delivery looking forward.
"Those who talk about the future are scoundrels. It is the present that matters."
To be successful, a drug delivery technology must bring a real advantage to the patient (e.g., improved efficacy, safety, compliance), the caregiver (e.g., convenience), the care payer (e.g., a pharmacoeconomic advantage), and the company itself (e.g., increased sales, decreased cost of goods, extended patent life). This article will attempt to assess new drug delivery technologies likely to affect the market. In making this assessment, the author identified areas where improvements in delivery are most needed to create a "top ten list" of opportunities in drug delivery
The biopharmaceutical market was valued at more than $70 billion in 2005.2 Most of these proteins are being administered by injection. Given patient preferences for less invasive routes of administration, one can only imagine what the sales for therapeutic proteins would be if they could be given orally. It is easy to see why many consider the oral delivery of proteins to be the holy grail of drug delivery.
Despite decades of work toward oral delivery of therapeutic proteins, progress has been fairly limited. This can be attributed to the multiple challenges faced in this area. First, the protein must survive the low pH of the stomach, which is typically pH 1.5–2 in fasting adults.3 Next the protein is exposed to numerous enzymes present in the gastrointestinal (GI) tract, many of which are designed to hydrolyze proteins.4
If one is able to overcome these obstacles, the protein still must be absorbed through the intestinal mucosa. Permeability of proteins through cell membranes is extremely low. Their large molecular weights and high hydrogen-bonding capacity,5 makes significant transcellular passive diffusion through membranes unlikely. Although the intercellular space between adjacent epithelial cells offers an aqueous pathway for protein diffusion,5 this space is limited by the presence of tight junctions, and provides a small surface area relative to the total epithelial surface. Finally, once absorbed, the protein must survive first-pass metabolism.
The therapeutic index and cost of goods of the protein will also be factors in determining the feasibility of oral protein delivery. Due to the hurdles described above, it is reasonable to expect low, variable bioavailability. Thus, proteins with a narrow therapeutic index or high cost of goods will not be ideal candidates.
On September 8, 2005, an FDA advisory committee panel recommended the approval of Exubera, which delivers insulin by the pulmonary route using Nektar Therapeutics' dry powder inhaler. This approval is impressive given the many hurdles it had to pass, including the narrow therapeutic index of insulin and the need for strict particle size control to reach the alveolar surface.


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rightcunnin wrote:Theyirban wrote:Is that the whole 80 35 then? Crappiest line up I've seen, and unfortunately the first year I can attend. Dinosaur Junior is great, Leftover Salmon and Avett Bros. good. Anyone know about the rest?
will keep announcing acts over the next month or so.
Still looking like a POS. Too bad; tough to get acts these days I guess.


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Find Cleveland Orchestra
Program Notes
This database is an index of the complete program notes (and subsequently, the performances) of the Cleveland Orchestra. The database is produced from the actual programs, held by the Robinson Music Library.
Scope: 1921-22 through 2014-15 seasons. The database is being updated continually as indexing is completed.
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Upcoming Events
September 21, 2016, 8:00 pm
Severance Hall
Cleveland Institute of Music Orchestra
Carl Topilow, conductor
Christianna Bates, viola, student artist
Faculty Recital
September 23, 2016, 8:00 pm
Mixon Hall
Alberto Ginastera: Music for Cello and Piano – A Centennial Celebration
Mark Kosower, cello
Jee-Won Oh, piano, guest artist
Faculty Recital: Boulez Legacy Series
September 25, 2016, 4:00 pm
Mixon Hall
Mary Kay Fink, flute
Frank Rosenwein, oboe
Robert Woolfrey, clarinet, guest artist
Barrick Stees, bassoon
Richard King, horn


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10 Bachelorette Party Cocktails
2 oz. Blue Ice Organic Wheat Vodka
1 oz. agave nectar
1 oz. lemon juice
5 mint leaves
Garnish: lemon zest
Tear mint into a shaker. Add ice, vodka, agave nectar, lemon juice, and shake vigorously. Strain into a cocktail glass and garnish with a lemon zest.
2 oz. Crop Organic Vodka
Muddle strawberries in a mixing glass. Add vodka and a splash of soda, and top with lemonade.
Source: Robert Honeycutt, Gilt Bar & Restaurant General Manager
16 Neon Cocktails You Have to Try


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Samantha Swallows is glowing, she has such high sexual energy that just pours out of her in this beautiful video. She is enjoying the California sun shining on her warm body as she shows off her blue top and mini skirt. She slowly takes off her sexy black panties making sure the camera catches lots of photos of her shaved pussy. Next off comes the black bra also making sure she shows you her perky titties. As she goes off to fantasy-land, she proceeds to masturbate in the lounge chair.
Samantha Swallows is like a sex cat on the prowl. A hot blonde in heat, the curvy temptress uses her inviting body as a lure that no straight man can resist. Yummy! Look at this girl's shape! That ass of hers is just begging for some doggie style. Go ahead and fantasize. Have tissue nearby for this one as Samantha masturbates like a champ!
Samantha Swallows AKA Lexi gets it on with the famous sex machine, the Sybian. She looks so adorable in her Aziani tank and sexy short mini skirt, she can pull that look off. She has this sweetness and gentleness about her, but once she let's go, she is a wild, crazy and very naughty girl. You'll see. Sit back and enjoy the ride!
Hottie Samantha Swallow moves around sensually in her sexy black dress while strategically raising and caressing her hands over her slinky dress. Once you are sufficiently captivated by her sexual energy, she sits down and begins a massage between her legs. With Samantha's toned legs spread apart she masturbates herself to an awesome orgasm and you get to watch.


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CORPUS CHRISTI – Junior guard Terence Jones (Baltimore, Md.) has earned honorable mention from the Southland Conference's coaches and sports information directors, the league announced today. Jones led the Islanders and finished seventh in the league with his 13.7 points per game.
Jones also earned Third Team All-Southland Conference honors from College Sports Madness, the website announced on Monday.
Jones had a strong season as the Islanders' scoring leader, finishing in double figures in 21 of the team's 30 games. He scored 20 points or more six times, including a career-high 33 in A&M – Corpus Christi's victory over Texas State on Jan. 25. He had at least four three pointers in a game on nine occasions, en route to 68 triples on the year – the third-highest total in school history. His 411 total points marked the eighth-best season in Islanders lore.
Through three years in an Islanders uniform, Jones sits 10th on the career scoring list with 874 points, leaving him 126 points away from being the ninth 1,000-point scorer in program history. He has buried 148 threes in his time on the Island, the third-best total among Islanders, and his 2,540 minutes place him eighth all-time. He sits fifth with 209 career assists.
The Islanders finished their first season under the leadership of Willis Wilson 6-24 overall and 4-12 in Southland play, despite having just 10 scholarship players and returning only Jones and Chris Hawkins-Mast as players who had significant experience. The Islanders had five freshmen average at least 10 minutes a game with an average of 11 starts apiece.
For all the latest on Islanders Men's Basketball, be sure to follow the team on Twitter (@IslandersMBB) and "Like" the team on Facebook (Search: Islanders Men's Basketball).


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A Cass County jail inmate has pleaded guilty to escaping while a law officer was escorting him to a court appearance in Fargo.
The Forum newspaper reports (http://bit.ly/XlHQZX ) that 25-year-old Francisco Ayala Jr., of West Fargo, was sentenced to 1 ½ years in prison on the felony escape charge Monday. He also faces federal drug charges.
Authorities say Ayala used a makeshift key fashioned from two wire springs and a broken pencil to undo his handcuffs and leg restraints and flee from a sheriff's deputy on Oct. 12. He was on the run for less than an hour before being apprehended without incident in an apartment, but the incident prompted lockdowns at five area schools.
Location, ST | website.com