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Process analytical technology (PAT) is being successfully used to improve understanding and optimize pharmaceutical unit operations, but greater value can be obtained by integrating PAT with overall process control of a continuous manufacturing system. Pharmaceutical Technology spoke with Ivo Backx, manager of business and project development for the pharmaceutical industry at Siemens Industry Automation Division, to gain insight on the issues involved.
PharmTech: What is involved in using the data from PAT measurement to control a pharmaceutical process?
Backx: Regulatory authorities are pushing the pharmaceutical industry to better understand the manufacturing process and to measure the attributes that are critical to the final quality of the manufactured product, with focus on the therapeutic effect of the medicine. Critical to quality attributes (CQAs) must be measured and monitored against deviation limits. Parameters that are critical to the process (CPPs) must be controlled in order to keep the CQAs within the design space and continuously produce the right product with the right quality.
In the SIEMENS PAT quality data management system (SIPAT), the first step is to collect all relevant data from different sources, such as multivariate data from spectroscopy instruments as well as univariate data from classic instrumentation. The spectrum from an analyzer can be read out over a direct interface. Univariate data is typically already available in the process control system and can be collected from there. Data from off-line laboratory tests may be of interest as well and can be obtained over an interface to a laboratory information management system (LIMS). Principally, data from the different sources must be collected and integrated. In this process, time alignment is very important as the data are collected at different sample rates in the different systems. Context data (e.g., equipment identification, product-plug identification, batch or lot identification) are retrieved from the process control system and added to the data, thus allowing for product tracking and process data mining.
Statistical data regression models are applied to the collected data using chemometrics software runtime engines. The result is a value of the CQA (e.g., moisture content or particle size). The derived CQA can then be aggregated to calculate standard deviations and averaged values and can be monitored over time in a trend display. The aggregated values of the different CQA data over different unit operations of the total manufacturing process are the basis for advanced process control for closed-loop, model-predictive control, which steers the CPPs in the process control system. The different calculated CQAs are stored electronically and are the basis for real-time release evaluation.
PharmTech: How are these systems being used today in finished solid dosage processes (e.g., tableting)?
Backx: Today, PAT instruments are often used on single unit-operations to measure a CQA. Often, they are applied for closed-loop control but isolated to a single process step. For instance, moisture content is measured to determine the end point of a drying cycle. Hardness and thickness are measured and controlled in the tablet press. The concentration of the active ingredients may be verified basing on NIR analysis of tablet samples after the press.
In order to get in-specification product the first time and all the time, however, the control strategy must be to take all the CQAs into considerations and deploy a feed-forward/feed-backward process control strategy over the complete manufacturing process.
PharmTech: Are there any other issues that limit the use of PAT in process control?
Backx: Today, PAT instruments still have dedicated, proprietary interfaces. Now a new interface standard, the OPC UA ADI (Object Linking and Embedding for Process Control Unified Architecture for Analytical Device Interfaces), exists, but few instrument suppliers support it. Another problem is that spectroscopy instruments are quite expensive. They are typically applied in laboratory environments and require more robustness to support a commercial manufacturing. This situation, however, is changing fast as new instruments come on the market. Another issue is that multidisciplinary teams are required to develop and maintain the PAT solutions, which is a challenge for most organizations.
Process equipment suppliers often have a single PAT solution integrated in their equipment controls, with local data management on the local equipment human-machine interface. Validation of isolated, single operation solutions is a pain; tighter integration is a must. Platforms that integrate all CQA data from different sources (i.e., online, inline, at-line and off-line) into one central quality data management tool and deploy the overall control strategy from a central system should be used.
—Ivo Backx is manager of business and project development for the pharmaceutical industry at Siemens Industry Automation Division, www.siemens.com/Pharma.


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medicinal funk wrote:he refused to let them go without me paying. and two of greco's discs: both are pearly wraiths one with an iron lion stamp.
frogawitdafizzle wrote:I guy named Kim Tebbe turned them in, you could reward him with you find and I think he would be delighted
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@ shagrath
Thanks a million for a great media server. After endless tweaking with TVersity I find your PS3 Media Server very easy to setup.
Now for some reason I can see picture/photo folders and sub folders thru PS3 Media Server but when I try to view photos (JPEGs) I get "There are no titles" error.
Do I need to tweak a setting or something to view photos ? Many thanks in advance, - Jags


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ps3newbie wrote:(I only hear sound when I fast-forward the video 1.5x but the sound is also at 1.5x faster)
Electrifying wrote:Just experienced the exact same issue as ps3newbie has. So it is not an incidential case.
if ac3, try to play with the "remux ac3" option on mencoder config panel, but not sure it will help
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Bethel College associate registrar Kay Schmidt has announced the names of Bethel College students whose fall 2013 semester grades have earned academic distinction.
Students are eligible for semester honors provided they complete a minimum of 12 letter-graded hours and do not have an I (Incomplete), NR (Not Reported) or IP (In Process) in any letter-graded courses — with the exception of seminars — that term. Class designations are made according to the number of hours completed.
Students named to the Dean's List (3.7 to 4.0 semester GPA):
- Tyler Kaufman, Moundridge
- Tana Myers, McPherson
- Daniel Ratzlaff, Moundridge
- Chase Stucky, Moundridge
- Jennifer Kaufman, Moundridge
- Renae Stucky, Moundridge
- Shenise Allen, Moundridge
- Marike Stucky, Moundridge
- Taylor Stucky, Moundridge
Students named to the Honor Roll (3.5 to 3.69 GPA):
- Jason Friesen, Inman
- Ethan Knight, Moundridge
- Michelle Kaufman, Moundridge
Bethel College is the only private, liberal arts college in Kansas listed in the 2013-14 Forbes.com analysis of top colleges and universities in the United States, and is the highest-ranked Kansas college in the Washington Monthly annual college guide for 2013-14. The four-year liberal arts college is affiliated with Mennonite Church USA. For more information, see www.bethelks.edu.
Location, ST | website.com


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At a time when most consumers download music one track at a time and listen to tunes with little concern for an artist's intended sequencing, jazz singer Jacqui Naylor knows that she's swimming against the zeitgeist. But wedded to a creative process in which songs often serve as threads in a larger narrative, the Saratoga-raised vocalist isn't about to give up the concept album format any time soon.
"If I'm going to tell a story through a collection of songs, I feel it's important there's a concept behind it. I'm a big believer in creating boundaries to work within," says Naylor, who celebrates the release of her ninth album, "Dead Divas Society" (Ruby Star Records), Friday at the SFJazz Center's Miner Auditorium. She's hosting a preconcert reception steps away from the center at Gourmet & More to benefit the San Francisco Domestic Violence Consortium, an organization to which she's also donating a portion of her fee.
Twist on a tribute
Naylor's provocatively titled new project offers a fascinating twist on the tribute album. Recorded before a small audience at Coast Recorders in San Francisco, a self-imposed challenge that meant minimal opportunities for fixes and postproduction editing, "Dead Divas Society" is a collection of 15 songs, each intimately tied to a particular vocalist. Deciding on which divas made the cut turned out to be a painstaking process.
"I thought this was going to be one of the easiest albums, but I got almost compulsive and maniacal about doing the research," Naylor says. "I had all these rules for myself around creating the record. I wanted songs from every decade for the last 80 or 90 years. Above all, I had to pick artists who really impacted me."
With her throaty, whiskey-laced sound and slyly off-center phrasing, Naylor doesn't have obvious aural influences. As an artist who often writes original material, she naturally settled on jazz's greatest singer/songwriters, Blossom Dearie and Peggy Lee (the latter being the only vocalist represented by two songs, her gospel-steeped "It's A Good Day" and Johnny Mercer and M. Philippe-Gérard's nostalgia-laden "When the World Was Young").
Wide range of divas
Naylor's idiosyncratic definition of divahood provides the album with a steady flow of unanticipated material. Sure, she includes songs by Ella Fitzgerald ("Skylark"), Sarah Vaughan ("Gravy Waltz"), and Billie Holiday ("Crazy He Calls Me"), but she also gleans effective jazz vehicles from Amy Winehouse ("Back to Black"), Mama Cass Elliot ("Dream a Little Dream of Me"), and Queen's Freddie Mercury ("Love of My Life").
Clearly, Naylor's notion of a diva isn't dependent upon gender, highhanded behavior or old-school glamour. She included Cass Elliot when she got a wave of feedback from friends, family and fans. In some cases, a singer came to represent an entire school of jazz singing, so that cool June Christy stands in for Julie London, Chris Connor and Anita O'Day with "It's a Most Unusual Day."
Choosing the singers
"I started with a really big list of artists," Naylor says. "Ella and Sarah were obvious choices. Blossom was obvious, because even though I don't sound anything like her, she was very influential to me. I thought about Michael Jackson, but I haven't covered a lot of his tunes. Whitney Houston was on my list, but I decided I wanted a man for that contemporary R&B slot, so I chose Luther Vandross."
Musically, Naylor's concept goes far deeper than a series of hat tips to fellow singers. Often honed to pop-song concision, clocking in at less than three minutes, the arrangements flow from the entire band, particularly pianist Art Khu (who happens to be Naylor's husband). Friday's show features her working band, with Khu, drummer Josh Jones and bassist Sam Bevan.
"The album is really about all of us playing together and playing off of each other," Naylor says. "Josh is on my last album, 'Lucky Girl,' too, and credited with a lot of arranging. He's the one who suggested adding the reggae tune for Nina Simone, 'Feelin' Good.' "
A self-described "nice Buddhist girl," Naylor grew up in Saratoga, the youngest of seven kids. She graduated from Archbishop Mitty High School, where she participated in musical theater. While studying acting at ACT, she realized that she had far more aptitude for delivering lines as a singer, which led her to the great vocal teacher Faith Winthrop at the San Francisco Conservatory of Music.
"Up until then, singing was a hobby on the side," Naylor says. "She said, 'I think you're a singer.' I credit her with helping me to find my voice, not trying to sound like anyone else."
When: 7:30 p.m. Friday
Where: SFJazz Center, 201 Franklin St., San Francisco
Tickets: $20-$40, 866-920-5299, www.sfjazz.org


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MARIETTTA - Super Bowl XLVII was showing on all six screens Sunday night as football fans at the Boathouse BBQ restaurant in Marietta watched the championship contest between the San Francisco 49ers and Baltimore Ravens.
The score was 21-3 in favor of the Ravens as halftime approached, but that wasn't a problem for 49ers fan and San Francisco-area native Shawn McCloskey.
"We lived about 45 minutes away, and my dad used to take us to 49ers games," he said. "They're off to a slow start, but they'll get with it in the end. After all, it's only halftime."
Article Photos
San Francisco-area natives Shawn McCloskey, left, and Alyse Hoeksema watch Super Bowl XLVII on Sunday night at the Boathouse BBQ restaurant on Virginia Street in Marietta. (Photo by Sam Shawver)
Fellow Californian Alyse Hoeksema, from the San Francisco Bay area, said she loves the Harbaugh brothers- John, head coach of the Ravens, and younger brother Jim, who's coaching the 49ers.
"But I'm pulling for the Ravens," she said. "This is (linebacker) Ray Lewis' last year, and I really want to see them pull through."
A few blocks north of the Boathouse BBQ, patrons lined the bar and tables to watch the game at the Harmar Tavern on Maple Street.
Mark Fleming, of Marietta, was rooting for San Francisco.
"But I'm surprised that the Ravens are ahead by this much," he said at halftime. "I still think San Francisco will take it back during the second half."
Across the room Brent Casto, of Marietta, and Melissa Digioia, of Williamstown, took opposite sides on the game.
"I'm for the 49ers - I just like the city of San Francisco," Casto said. "I really wanted Denver to be in the Super Bowl, but that didn't happen."
Digioia was backing the Ravens.
"They beat the Patriots a couple of weeks ago, so I'm pulling for them," she said.
A small crowd also gathered at Marietta's First Presbyterian Church to watch the game Sunday night.
"It's our first Super Bowl party here," said Pastor George Spransy, who recalled watching the very first Super Bowl while he was in seminary.
"We watched the game, between Kansas City and Green Bay, from Richmond, Va.," he said. "It was January 1967 and the Packers won 35-10. Little did I realize we'd still be watching a Super Bowl game 47 years later."
Spransy wasn't a fan of either team Sunday night.
"I'm just a fan of football," he said.
Ali Neff, of Marietta, was also watching the game at First Presbyterian.
"I just like the commercials - they're so funny," she said. "I'm not really for either team, although it is interesting that the coaches for both teams are brothers."
Libby Rogers, of Marietta, said she had to take the middle ground when it came to the Super Bowl rivalry.
"I really love football," she said. "But neither team is my favorite. I have three daughters living in Baltimore who are Ravens fans, and my son is in Stockton, Calif., so he's for the 49ers."


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St. George Parish School will have an open house and registration, for families with children grades K-8, at 11 a.m. Sunday in St. George Hall, 144 W. Fifth St., Stockton. There will be a tour of the school facilities, and teaching and administrative staff will discuss the curriculum and financial aid program.
Information: (209) 463-1540.
Stockton Area Atheists and Freethinkers will hold its monthly Sunday get-together at 5 p.m. this Sunday at The Clubhouse, 2250 Scarborough Drive, Lodi.
Join the group for food, fun and entertainment. The event is free, but attendees are asked to bring a food to share or $5 to $10.
Information: David, (209) 610-0651.
Instructor Chinu Mehdi will teach free classes on the practice of yoga being beneficial to help cancer patients from 5:30 to 7:30 p.m. every Monday, Classrooms 1 & 2, St. Joseph's Medical Center, 1800 N. California St., Stockton.
Registration and Information: (209) 461-5443.
SCORE Stockton will hold a free workshop on small business planning from 9 to 11:30 a.m. Wednesday at the WorkNet Building, 56 S. Lincoln St., Stockton.
This workshop is being held in conjunction with the Small Business Development Center at San Joaquin Delta College.
SCORE is affiliated with the Small Business Administration and offers free business mentoring for startup or existing businesses.
Information and registration: scorestockton.org or email firstname.lastname@example.com.
Amador County Master Gardeners will have two free classes beginning at 9 a.m. Feb. 2 in the GSA Building, 12200-B Airport Road, Martell.
The topics are Living in the Forest and Defensible Space Landscaping. Learn why you should clear brush and thin trees, how to recognize some common pests and diseases of conifers and oaks, and about the wildlife that share the forest with you and how to live in harmony with them.
Information: (209) 223-6838 from 10 a.m. to noon Tuesday-Thursday or email@example.com.
The Stockton branch of the American Association of University Women (AAUW) is holding its February meeting and luncheon at 9 a.m. Feb. 9 at the Lincoln Farmhouse, 3125 Deer Park Drive, Stockton.
The program's focus is to celebrate Black History Month. Speakers include Tama Brisbane, the executive director and CEO of "With Our Words"; and Geraldine Hollis, author of "Back to Mississippi."
The cost is $16 for the meeting with lunch, or $5 without the lunch. Reservations are required and must be made by Feb. 3.
Information: (209) 951-6822 or (209) 473-4073.
Location, ST | website.com


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cap 1
- He wore a flat cap, old woolen trousers, and a brown shirt that was several sizes too large for him.
- Outside the grand clubhouse at the Legends course, at the heart of Château Elan, you almost expect chaps to be wandering around in plus-fours and flat caps.
- Most men covered their heads with flat wool caps or skullcaps or turbans in a variety of sizes and colours.
- Those early wheelmen didn't have bicycle helmets, but they did wear close-fitting long-visored caps.
- Opened in November 2001, it's run by two brothers with similar close-cut reddish beards, ethnic clothes and close-fitting caps.
- If you think you can pull off any look, then I suggest you try on this chalk-stripe driving cap.
- He won his cap for the Portuguese national side at an early age.
- Hughes earned 62 caps for the national team and led Liverpool to a string of honours while at the Anfield club.
- Baggio completed a full 90 minutes and showed flashes of the ability that won him 60 caps for the Italian national side.
- Both new caps fullback Peter Gibson and lock Paul Barker admitted to being a little nervous before flying out with the team yesterday afternoon.
- It gives them a motivation to become a national cap and an international Test cricketer.
- He and his dad Terry will be paired up as change bowlers, with the attack expected to be opened by two new caps, Paul Hart of Spring View and Steve Holt of Clifton.
- But in field after field, paper journals are becoming like academic caps and gowns, a purely ceremonial relict of an obsolete culture.
- The same percentage of MIT engineering graduates in their caps and gowns could not light a bulb with a battery and one wire.
- Your proud high school graduate has gone from caps and gowns to the fast-paced, challenging world of summer jobs.
- She pointedly puts the cap on her camera lens and walks with him.
- Someone cleared their throat, and Artemesia straightened up, snapping the lens cap onto the camera.
- This includes bottle caps, tin covers or aluminum foil - these are some of the items service technicians commonly find in clogged or broken disposals.
- Then, Bodine suffered a concussion and a broken collarbone and needed eight caps for his teeth because of a practice crash at Michigan.
- Her whole jaw was bruised, her cap for her tooth cost £404.
- While your dentist might still recommend an apple a day and be able to fit natural-looking caps, the latest orthodontic innovations concentrate on stopping decay before it has a chance to do any damage.
- Their heads are also relatively smaller and their gray caps less distinct than the Cooper's.
- The crane has light to dark blue-gray plumage and a crimson cap at the back of its crown.
- Males and females look the same, with white chins extending up just below the eyes and gray-brown caps.
- He promises to impose spending caps and offset spending increases with mandatory spending cuts or tax increases.
- He was complaining about the absence of a cap in campaign spending before the formal election period, even though it was his party that exploited this loophole prior to the last election.
- This time around, spending caps may not be enough.
- Find out from this factsheet by the fpa how contraceptive diaphragms and caps work, how effective they are at preventing pregnancy and their advantages and disadvantages.
- Diaphragms and caps are barrier methods of contraception.
- Barrier methods of contraception include diaphragms, condoms and cervical caps.
- Coral mushrooms do not have caps but instead have a fruiting body of branched clusters.
- The cap & stem that we commonly eat is just the fruiting body.
- Five tall, slender mushrooms with yellow stems and glowing orange caps reach through the decaying foliage toward the sky as ants burrow underground.
- So, before you buy that cap gun or bouncing ball for your child, take some precautions.
- We started selling snap caps a little over a year ago.
- Like many boys he had been fascinated with guns when a young child and had the usual cap guns and nerd guns.
verb (caps, capping, capped)[with object]
- After capping it, the bottle should be shaken for 20 seconds.
- He said that there have been discussions to change the technology of capping the wine bottles but so far the cork has remained.
- When I capped the pen and folded the paper R. asked with surprise, 'You're done?'
- The controversial hole in the ground will be capped with a layer of clay when planning permission runs out in December and landfill operators begin what they call 'restoration' of the site.
- The radiocarbon-dated feature that produced the wild rice was located at the bottom of an undisturbed Late Woodland midden that had been capped with a layer of sterile sand.
- Reclamation dredging is nearing completion and all reclaimed land will then be capped with a layer of rock, imported from a nearby quarry.
- Coals flashed Marcus a grin, so full of perfectly capped teeth, so taut at the lips, so fleshy at the gum line that for a split second the image of a shark in an expensive wool suit was unavoidable.
- If they've got bad teeth, you'll cap the teeth, if they need a makeover, you give them a makeover.
- The scenes that are presumably supposed to depict camaraderie are hilariously forced; three sets of perfectly capped teeth clenched into rictus grins of barely suppressed hatred.
- It capped a memorable first season in charge for Wetheriggs manager Andrew Ridley, his assistant Bob Norman and coach Paul Renwick.
- Katie Heginbotham from Barrows Green triumphed at HOYS to cap a memorable season.
- The Reds, however, were not finished and they capped a memorable afternoon with a fifth try in the final minute when Darren Treacy forced his way over from close range.
- Cave's not a lunatic on a killing spree; he's a lovelorn bombmaker, and he caps this cinematic story of devotion with a spirited sing-along.
- Mac McMurray capped this story by saying a townsman had a piece of petrified fence post with the drilled holes for wire with a piece of the wire attached.
- Ruth would have felt the need to cap the comment in some way, or qualify it, or even dismiss it out of hand as arrant nonsense.
- If it caps the price of wonder drugs, pharmaceutical companies will fight it.
- One of the most controversial recommendations of the report calls for the government to endorse a package of measures to fundamentally reform the property market by capping the price of development land.
- He said he hoped the government's measure to cap fuel prices should not last too long because it could have repercussions in the long run.
- The Scotland full-back was capped 57 times during two decades with Celtic.
- He was capped after just 12 league games for Arsenal and scored a century on his Test debut.
- He has done everything he wanted to do - of course, he was capped by England at Rugby Union when he went back to that game.
- Kate Edger was appointed to teach at Christchurch Girls' High School and at the same time studied for a Master of Arts degree from Canterbury College and was capped in 1882.
- Suspicions have been raised the letter bore a Manawatu postmark and may be linked to a capping stunt at Massey University.
- The first ballet troupe I ever saw was the Selwyn Ballet at Otago University's annual capping concert, which summed it all up, really.
- 1
- British Humbly asking for a favour: we have to go cap in hand begging for fundsMore example sentences
- Tight new spending limits are set to be imposed on Britain's political parties to stop them going cap in hand to donors angling for peerages, knighthoods and other favours.
- With every voter putting no more than five dollars into the Clean Money pool, candidates won't have to go hat in hand to lobbyists and fat cats, instead spending their time talking to voters.
- Rather than going hat in hand to pharmaceutical executives, Canada uses single-payer's price controls to cap drug prices.
cap of maintenance
- British A cap or hat worn as a symbol of official dignity or carried in front of a sovereign on ceremonial occasions.Example sentences
- Then comes the royal procession, with Baroness Amos carrying the cap of maintenance, a sort of scarlet bonnet with red trim.
- The coat of arms of the city includes the 'cap of maintenance', giving the Sheriff the right to raise an army independently of the Crown.
- The King rewarded the city with gifts - the famous cap of maintenance and sword, brought back home by William who was knighted later in life.
- 3
- British Used as a way of suggesting that someone should accept a generalized remark or criticism as applying to themselves.Example sentences
- So whether or not you have £1m to spare, if the shoe fits, wear it - if only while you're hoovering.
- So (if the cap fits, wear it) I was also there for you, comrades, citizens and Guardian-readers.
- It kills me to write things like that, but if the shoe fits, wear it.
set one's cap at (or US for)
- dated (Of a woman) try to attract (a particular man) as a suitor: she should buy herself a new frock and set her cap at someone elseMore example sentences
- Had she picked a Lord, or a Viscount, or someone of standard to set her cap at then her father wouldn't have voiced a single complaint.
- Into this mix Brooks introduces two young catalysts, journalist Eve, who immediately draws Dan's attentions, and easygoing Gord, who sets his cap for Gena.
- A brutalised war veteran, Harvey has begun a steamed - up adulterous affair with Signoret and finally found something like love, but sets his cap for a millionaire factory boss's daughter.
to cap it all
- As the final unfortunate incident in a long series: she was on edge, her nerves taut, and to cap it all, she could feel the beginnings of a headacheMore example sentences
- There's more of everything, a plethora of competing versions vying for the user's attention and, to cap it all, the web is so jam-packed with information that it's getting harder by the day to sort the wheat from the chaff.
- For Michael, his trainers, his employers and, of course, his family, travelling to South Korea to represent his country was a real thrill - and to cap it all, he came back with a Diploma of Excellence.
- And then, to cap it all, I set the video for the Billy Wilder double bill on BBC2, only to see that it's been cancelled on account of the golf from Augusta.
capfulnoun (plural capfuls)
- Example sentences
- I like to incorporate a capful of liquid wetting agent into the water when I am feeding my annuals, vegetables, pot plants and hanging baskets with soluble fertiliser.
- The next stage is to soak them for a day or so in a diluted solution of household bleach (say two pints of water to a capful of bleach).
- A cup of white vinegar or one capful of eucalyptus oil may be added to the soapy water as a disinfectant and freshener.
Old English cæppe 'hood', from late Latin cappa, perhaps from Latin caput 'head'.
We get our word cap from Latin cappa 'hood', which may be related to Latin caput 'head'. Cape (late 16th century), 'a cloak', also come from cappa, while the geographical cape (Late Middle English) goes back to caput. The same source gives us chaperone (Late Middle English) first recorded as a hood. A person providing protection or cover by accompanying another, dates from the early 18th century. The saying if the cap fits, wear it goes back to a dunce's cap, of the kind that poor performers at school had to wear as a mark of disgrace. Americans use the version if the shoe fits, wear it. See also chapel
Words that rhyme with capbap, chap, clap, dap, entrap, enwrap, flap, frap, gap, giftwrap, hap, knap, lap, Lapp, map, nap, nappe, pap, rap, sap, schappe, scrap, slap, snap, strap, tap, trap, wrap, yap, zap
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cap 2
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The Conference Board provides a rich array of actionable, authoritative economic data on the business cycle, labor demand and trends, and several barometers of consumer and business confidence, including the widely quoted Consumer Confidence Index and the Leading Economic Indicators. Our Chief Economist and a team of economic experts update our monthly forecasts and provide additional insights.
- Consumer Confidence
30 Aug. 2016
- Employment Trends Index
08 Aug. 2016
- Help Wanted OnLine
03 Aug. 2016
- Leading Economic Index
18 Aug. 2016
- Measure of CEO Confidence
07 Jul. 2016
- International Labor Comparisons Program
17 Dec. 2014


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About the Book
When it comes to devouring her delightfully outrageous, phenomenally fun fiction, Meg Cabot's fans are Insatiable! And now the #1 New York Times bestselling author of The Princess Diaries—not to mention a host of wonderfully winning grown-up novels like Queen of Babble, Big Boned, and Every Boy's Got One—has a subject she can really sink her teeth into: vampires! A deliciously twisted modern-day sequel to Bram Stoker's classic Dracula, Cabot's Insatiable will leave you laughing…and hungry for more!<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
Sick of hearing about vampires? So is Meena Harper.
Meena Harper is familiar with the supernatural. After all, she knows how you're going to die (Not that you're going to believe her. No one ever does.)
But not even Meena's precognition can prepare her for Lucien Antonescu—who she meets and then makes the mistake of falling in love with—a modern-day prince with a bit of a dark side for which an ancient society of vampire hunters would prefer to see him dead.
The problem is Lucien's already dead. Maybe that's why he's the first guy Meena's ever met with whom she could imagine herself having a future. See, while Meena's always been able to see everyone else's destiny, she's never been able look into her own. Lucien seems to be everything Meena has ever dreamed of in a boyfriend, though he might turn out to be more of a nightmare.
So now would be a good time for Meena to start learning to predict her own future . . . if she has one.
Educator and Librarian Resources
Product Details
- Imprint: William Morrow Paperbacks
- On Sale: 06/07/2011
- Trimsize: 5.313 in (w) x 8 in (h) x 1.045 in (d)
- Pages: 464
- List Price: 14.99 USD
- BISAC1: FICTION / Contemporary Women


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Binnington Named OHL Player of the Week
Blues' prospect was drafted in the third round (88th overall) in 2011
Monday, 11.19.2012 / 2:10 PM CT / St Louis Blues - News
St. Louis Blues
ST. LOUIS – The Ontario Hockey League (OHL) has named Blues goaltending prospect Jordan Binnington as the OHL Player of the Week for the week ending Nov. 18.
Binnington, 19, posted a 2-1-0 record, a 1.34 goals against average and a .956 save percentage for the first-place Owen Sound Attack last week, becoming the first goaltender to earn Player of the Week honors in the OHL this season.
In addition, the Richmond Hill, Ontario native recorded a pair of shutouts, including the 66th win of his career on Nov. 17, moving him past former Blue Curtis Sanford for first on the Attack's all-time franchise list.
Overall, the Blues' 2011 third round draft pick (88th overall) owns a 13-3-1-2 record this season and ranks second among all OHL goaltenders with both a 2.18 goals against average and a .932 save percentage.


text:
SEO Experts London
Hi I'm Dave Ellis owner of Local Marketing Results the number one internet marketing company in Dartford and the South East and we are now entering the London SEO market place.
I am part of a group of agencies and consultants that rank tens of thousands of highly prized keywords on the 1st page of Google in some of the most hotly contested towns and cities such as London, Nashville and St Louis to name but a few.
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Complete our Discovery Page or Call 01322 329 493
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text:
Two prepubescent pals — the uploader's goddaughter and her best friend — love lip-syncing along to Gotye and Kimbra's "Somebody That I Used to Know."
Inspired by their budding puppy romance, the girl's godmother spliced together a bunch of clips featuring the duo doing their thing, and set it to the chart-topper to create an adorable alternative music video for the song.
(First an acceptable flash mob, and now an acceptable lip dub? What's next? An acceptable public proposal video? Ha ha NO.)
Erratum: The girl's dad writes in to clarify that the video was actually shot and cut by "the boy's mom's boyfriend" and not the girl's godmother, as above.


text:
EMA limits use for MS pill Gilenya
23.04.2012 - Novartis' multiple sclerosis pill Gilenya will have its label updated in the EU, enabling physicians to better manage potential adverse effects on the heart.
London – The European Medicine Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended that all patients beginning treatment with Gilenya (fingolimod) should have an electrocardiogram before taking the first dose and for six hours after. The body also recommends regular blood pressure and heart rate monitoring. The CHMP advises that heart activity monitoring should be extended for patients whose heart rate is lowest six hours after receiving the first dose, and that patients who develop clinically significant problems like bradycardia or atrioventricular block should be monitored until the problems have been resolved. The CHMP also adds that doctors should no longer prescribe the drug to patients with cardiovascular and cerebrovascular disease, or to patients on heart-rate lowering medications. But if these patients must receive Gilenya, their heart activity must be monitored at least over night after taking the first dose
Gilenya has been authorised in the European Union (EU) since March 2011 for the treatment of relapsing-remitting MS in patients who have not responded to treatment with beta-interferon or whose disease is severe and getting worse rapidly. It is the first disease-modifying MS treatment available as an oral formulation.
The EMA began a review of the drug in January following reports of heart problems in patients taking Gilenya. The CHMP looked at all available data on heart safety, including reports of 15 cases of sudden or explained death in patients treated with Gilenya. Most deaths occurred in patients with cardiovascular problems or those taking other medicines. However, it is still not clear if Gilenya was the cause of death. According to Novartis, some 36,000 patients have received treatment with Gilenya since Februaryhttp://www.european-biotechnology-news.com/news/news/2012-02/ema-limits-use-for-ms-pill-gilenya.html


text:
I have files encoded in x264, and using vorbis as audio codec in a mkv container.
Will ps3ms try to transcode both video AND audio. Or audio only and just remux the video?
Another question :
My mkv files have several audio but I can't seem to change it while playing through streaming. Is this normal?


text:
Top Definition
A complete numpty who is too stupid and inept to realise just how stupid and inept he really is. Also thinks he's a bit clever - usually a bit of a slap-head as well...
That Ian Duncan-Smith, bit of a potatohead i'nt he?
by monk September 08, 2003
Trending Now
Can you define these popular missing words?
A potatohead (abreviation: KK, from german "Kartoffelkopf") is a human with a potato-shaped head. However, the potato shape of the head is not disadvantageous to his / her prettiness, but rather an unique feature of the respective human's beauty.
A potatohead is usually owned by a potatoheadowner (abreviation KKB from german "kartoffelkopfbesitzer"), who normally is a male person, as women usually rather match the criteria of a KK.
A potatohead is usually owned by a potatoheadowner (abreviation KKB from german "kartoffelkopfbesitzer"), who normally is a male person, as women usually rather match the criteria of a KK.
Sarah is an example of a perfect potatohead
by kartofelkopfbesitzer May 17, 2011
One who is doesn't care to think things through or plan ahead.
A vacuous individual, a mental couch potato.
A vacuous individual, a mental couch potato.
What a potato head, he didn't even bother to check and see if there was enough gas in the car before we left.
by Panthera Atrox February 17, 2011
Anyone who embodies the stereotypical variations (i.e. big head, slanty eyes, below average member size) characteristic of the asiatic races.
Whoa! Look at that F.O.B. smoke his cigarette. He looks like a smoking potatohead!
by BJC December 01, 2003
Someone with a head that looks uncannily like a potato.
'That Jimbo lad, he's such a potato headed berk!'
by The Hedgehog Man September 18, 2008
A Latin American person of indigenous descent, typically with a round potato shaped head.
I took a trip to La Paz, Bolivia and man...there were Potatoheads everywhere.
by Yuccaface January 04, 2012
Racial slur referring to anyone of Irish descent (esp. males)
Get back to work you potato heads!
by S. O'Brien March 05, 2007


text:
Acccused co-conspirator in NY bomb plot appears in San Diego court
Next video starts in : 7 Play
Acccused co-conspirator in NY bomb plot appears in San Diego court
Little League Team Wins World Series Championship and a Perfect Season
2:26Now watching Up next
Acccused co-conspirator in NY bomb plot appears in San Diego court
One day after a man was arrested in New York, accused of trying to blow up the Federal Reserve Bank, an unindicted co-conspirator was in a San Diego courtroom.
1:18Now watching Up next
Little League Team Wins World Series Championship and a Perfect Season
The pint-sized team from Endwell, New York, ran the banner alongside their Korean competitors after their championship game.
1:23Now watching Up next
2 United Pilots Removed From Service for Allegedly Drinking Before Flight
The flight from Glasgow to Newark was delayed for 10 hours when the pair appeared to be over the legal limit.
2:17Now watching Up next
False Alarm Causes Massive Panic at LAX Airport
An actor in a Zorro costume carrying a plastic sword was detained by police.
2:13Now watching Up next
Comic Legend Gene Wilder Dies at Age 83
The "Willy Wonka" star and frequent Mel Brooks collaborator passed away from Alzheimer's complications.
0:59Now watching Up next
Index: Woman Killed in San Antonio Truck Explosion
Tom Llamas reports the stories people are buzzing about.
1:25Now watching Up next
Colin Kaepernick Back on the Field Despite Critics Calling For His Removal
The 49ers quarterback is receiving strong criticism for refusing to stand for the national anthem.
1:38Now watching Up next
EpiPen Manufacturer Responds to Political Pressure to Lower Prices
Mylan, the company that significantly increased the price of the life-saving device, announced a generic version.
2:23Now watching Up next
Florida Prepares for Tropical Threat in the Gulf of Mexico
Tropical Depression 9, which dumped heavy rain on Cuba, is expected to hit the state's Gulf coast.
2:53Now watching Up next
Huma Abedin Splits With Anthony Weiner Following Another Sexting Scandal
The disgraced politician reportedly sent lewd images with his sleeping son lying by his side.


text:
3.14-6 Retaliatory Discharge in
Violation of General Statutes § 31-290a
Revised to January 1, 2008
The plaintiff has
alleged that the defendant (terminated (his/her) employment
/ discriminated against (him/her)) in violation of
Connecticut General Statutes § 31-290a. Connecticut General
Statutes § 31-290a provides:
"(a) No employer
who is subject to the provisions of this chapter shall
discharge, or cause to be discharged, or in any manner
discriminate against any employee because the employee has
filed a claim for workers' compensation benefits or
otherwise exercised the rights afforded to him pursuant to
the provisions of this chapter."
In order to
prevail on (his/her) claim under § 31-290a, the plaintiff
must prove by a preponderance of the evidence that
((his/her) discharge / the adverse employment action) was
due to intentional discrimination based on (his/her) filing
a claim for workers' compensation benefits. Intentional
discrimination is proved in this case if the plaintiff
demonstrates by a preponderance of the evidence that
(his/her) filing a workers' compensation claim was a
motivating factor for ((his/her) discharge / the adverse
employment action) even though other factors also motivated
the defendant's decision to (discharge / take the adverse
action) against (him/her). A "motivating factor" is a
factor that made a difference in the defendant's decision.
The plaintiff does
not have to prove that the filing of a workers' compensation
claim was the sole or even the principal reason for the
decision, as long as (he/she) proves that it was a
determinative influence in the decision. (He/She) may prove
intentional discrimination directly by proving that
(his/her) filing the workers' compensation claim motivated
the defendant's action (in discharging (him/her) / taking
the adverse employment action) or indirectly by proving that
the (reason/reasons) given by the defendant for the
discharge (was/were) unworthy of belief. If you find that
the defendant's stated reason[s] are not credible, then
considering all the circumstances you may infer, although
you are not required to infer, that the filing of the
workers' compensation claim was a motivating factor in the
defendant's decision, even if it may not have been the only
motivating factor.
It is not your
role to second-guess the defendant's business judgment. As
long as the filing of a workers' compensation claim was not
a motivating factor that made a difference in its decisions,
the fact that an employer's decision was incorrect, unfair,
unwise or capricious, or even based on personal favoritism
or animosity is irrelevant.
Otero v. Housing Authority, 86 Conn.
App. 103, 108-109 (2004). Section 31-290a also prohibits
adverse employment actions against someone who "otherwise
exercised the rights afforded to him pursuant to the
provisions of this [workers' compensation] chapter." If the
plaintiff claims (he/she) was terminated because, for
example, the employer refused to accommodate (him/her) as
required by the workers' compensation statutes, then the
charge should be changed accordingly.
Third Circuit
Pattern Jury Instruction No. 5.1.2; Diamond Volume, L. Sand
et al., Modern Federal Jury Instructions – Civil (2006) pp.
3-188 - 3-189 (original available at
http://www.ca3uscourts.gov). The cases cited above all
follow federal law set forth in McDonnell Douglas.
The charge does not refer to the prima facie or burden
shifting aspects of McDonnell Douglas because whether
or not a plaintiff has established a prima facie case is an
issue for the court and many federal courts have found that
the burden sifting language has no place in a jury charge.
See e.g., Walther v. Lone Star Gas Co., 952 F.2d 119,
127 (5th Cir. 1992) ("the issue of whether a plaintiff made
out a prima facie case has no place in the jury room.
Instructing the jury on the elements of a prima facie case,
presumptions, and the shifting burden of proof is
unnecessary and confusing."); Ryther v. Kare, 11, 108
F.3d 832 (8th Cir. 1997) ("Instructions incorporating the
McDonnell Douglas paradigm add little to the juror's
understanding of the case, and, even worse, may lead jurors
to abandon their own judgment and to seize upon poorly
understood legalisms to decide the ultimate question of
discrimination."); Pivirotto v. Innovative Systems, Inc.,
191 F.3d 344, n.1 (3rd Cir. 1999).
While this
charge has not referred to the prima facie case or burden
shifting for the reasons set forth above, the Appellate
Court in Otero v. Housing Authority, supra, 86 Conn.
App. 110-11, approved a charge that stated: "The plaintiff
bears the initial burden of proving by a preponderance of
the evidence a prima facie case of discrimination. In order
to meet this burden, the plaintiff must present evidence
that gives rise to an inference of unlawful discrimination."
Jury Instructions |
Criminal Jury
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Español | FAQs |
Information | Media |
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Copyright © 2016,
State of Connecticut Judicial Branch


text:
Obama appeals court decision allowing abortion pill to be sold to kids of all ages
NEW YORK - The Obama administration on Monday filed a last-minute appeal to delay the sale of the morning-after contraceptive pill to girls of any age without a prescription.
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text:
Favorite DU Photos: December 2013
Member photos of the day from the month of December
Anyone want a hug? (photo by Mary Dow)
Opening day sunrise! (photo by Matt Wagner)
(photo by Corey Snyder)
Ideal morning from the blind. Semper Fi. (photo by Andrew Manaois)
Northern Shoveler (photo by Scott Denny)
Winter wood duck house (photo by Joel Godin)
(photo by Peter Giles)
(photo by Zach Tylka)
I am very fortunate to have all kinds of wildlife visit the pond in our and the neighboring yards, among them this beautiful wood duck. (photo by Melissa Ferguson)
(photo by Bert de Tilly)
0 Trey and his yellow lab Drake. (photo by Trey Claar)
1 (photo by Phillip Hansen)


text:
Revision as of 19:55, 13 September 2009
NOTICE! - The forums are being updated today from v3.0.3 to v3.0.5
New Users may register via Facebook!
About LEAKOIL
The Lake Erie Area Kombi Owner's Involvement League (LEAKOIL) is an informal organization of VW bus owners based primarily in Ohio and Michigan which uses Lake Erie as our geographic common denominator, and we are a chapter of NEATO.
We have a few dozen active members and several less-active members, but no one knows how many for sure because we do not "issue" memberships or keep a roster. We have no LEAKOIL Officers, no dues and no newsletter. The only criteria for membership is to own a VW bus or be thinking about owning one in the near future. Aside from meetings, VW public events, and campouts, our only visibility on the horizon is our web site which was established in February of 2007.
L.E.A.K.O.I.L. has no rules except for the "Golden Rule". At campouts and events members and guests are expected to respect others with a modicum of dignity that you would expect at a family gathering. Respect the Earth, and leave your campsite as nice or nicer than you found it. Respect your host(s) and their property, and tread lightly upon the land.
We hold a monthly meeting on the Third Thursday of each month. Currently we are meeting at Basil's Tavern & Grill. Interested VW bus owners are invited to join us between the hours of about 6pm and 9pm on meeting nights.
Our main club event of the year is "Kombis on Kelleys", a 3 day campout held on Kelleys Island in Lake Erie at the 4-H Camp on Columbus Day weekend. Our 2005 campout drew nearly 70 busses from several states. We also do several other campouts each season, as well as attend VW shows and swapmeets as a group. Current events updates can be found under the Upcoming Events section of this website.
For further information about L.E.A.K.O.I.L. contact any member, or post your question on one of the forums.


text:
|Please note: This system is designed for DAY OF Closings ONLY.
If you have a closing scheduled for more than 24 hours in advance, you must wait until midnight or after to submit the closing; otherwise, the closing will NOT appear in the system.
Next day closings and delays should be entered after midnight.
Example: If you have a closing at 9pm, for the following day, you must wait until AFTER midnight to enter the closing into the system. Again, the system is for DAY of closings ONLY.
Anything entered into the "Additional Information" field will only be displayed online. It will not be displayed on TV.
Please allow 5-10 minutes for your status to appear in the Closings list online.


text:
Good morning and welcome to Summit Up, the world's only daily column that's counting down the days until 2013. That's right, we're just itchin' to ring it in. There are only 73 more days of 2012. Make the most of them.
Now transitioning in no way, shape or form, we have this very clever poem sent in to us by Mr. Tom Tomlin from Silverthorne. Without further ado, Tomlin writes:
Whether the Weather is Nice
or Whether the Weather is Not
The Weather is, what the Weather is
Whether you like it or Not!
Brilliant! And speaking of the weather, it's been pretty chilly as of late. It's that time of the year, we guess.
Oct. 19 is a pretty special day in history. Here's a quick list of big events that have happened today in years past.
> 1987 - "Black Monday" - Dow Jones down 508.32, four times the previous record.
> 1963 - Beatles record "I Want to Hold Your Hand."
OK, so those events weren't that big, unless you just love the "Fab Four" or you had a solid financial portfolio. We here at the SU Corporate Suites feel that our portfolio remains strong to fairly strong.
That's about all we got. Happy Friday!


text:
The Arroyo High football team's defense was flawless in the first half, but the Tennyson offense scored 17 unanswered points in the second half to beat the Dons 17-10 on Friday night in a West Alameda County Conference-Shoreline Division game.
The Dons offense got it started in the first quarter, capitalizing on an interception thrown by Tennyson quarterback Gilberto Magallanes with a touchdown.
Malcolm Hale caught a 42-yard pass from Arroyo quarterback Isaac Tapia and, dodging two tackles, ran it into the end zone to get his team on the board.
Carlos Jimenez would add a 29-yard field goal in the second quarter, giving the Dons a 10-0 lead at halftime. But those were the last points they would get.
Tennyson running back Quinzell Moore found his stride in the second half, scoring both rushing touchdowns for the Lancers. He got his team on the board with a 20-yard run in the third quarter and gave them the lead with a 7-yard run in the fourth.
Jacob Brown tied the game in the third quarter on a 30-yard field goal. Tennyson's offense capitalized on Arroyo's mistakes, with their final 10 points coming off red-zone turnovers by the Dons offense.
Shoreline Division
Tennyson 17, Arroyo 10
Arroyo 7 3 0 0-- 10
Tennyson 0 0 10 7-- 17
A -- Hale 42 pass from Tapia (Jimenez kick)
A -- Jimenez 29 FG
T -- Moore 20 run (Brown kick)
T -- Brown 30 FG
T -- Moore 7 run (Brown kick)
Rushing: T -- Handy 16-50, Moore 12-61, Roger 1-12, Magallanes 3-(-12). Team: 32-111. A -- Harrison 9-18, Gordon 9-33, Jordan 2-3, Savage 1-1, Tapia 3-6. Team: 24-61. Passing: T -- Magallanes 5-12-1-69. Team: 5-12-1-69. A -- Tapia 6-16-1-113, Savage 0-1-0-0. Team: 6-17-1-113. Receiving: T -- Handy 2-11, Smith 1-6, Brown 1-37, Crusoe 1-15. A -- Hale 2-44, Magana 1-7, Savage 1-30, Gordan 1-6, Harrison 1-26. Fumbles/lost: Tennyson 3/1; Arroyo 2/2. Records: Tennyson 6-1, 2-0 Shoreline Division; Arroyo 3-4, 1-1.


text:
Upcoming Events:
Past Events:
NADC Seminar Series and Podcast: Year one of porcine epidemic diarrhea, what we learned
NADC Seminar Series and Podcast: Guts, Germs, Genes, and Glutamate. An Emerging Picture of Host Driven Enrichments
NADC Seminar Series and Podcast: Toward Biomarkers for Improving Disease Resistance in Pigs Using Blood Transcriptomics
-May9th NCAH Rm 1055
1st International NADC Animal Health and Food Safety Research Symposium
NADC Seminar Series and Podcast Cross Platform Tuberculosis Vaccine Diagnostics In Humans, Livestock, and Wildlife
Making Maps: Getting to Know a Microbial Community
NADC Seminar Series and Podcast! Regulation of Virulence and HostImmune Suppression in the Insect Pathogen Xenorhabdus nematophila
NADC Seminar Series and Podcast! Evolution of Glycan Utilization in Human Gut Bacteroidetes
- May 18th 2011
NADC Seminar Series and Podcast! TB Epidemiology and Control Options at the Wildlife/Livestock Interface in Spain.
NADC Seminar Series and Podcast! Persistant Colonization of Livestock by E. coli O157:H7
NADC Seminar Series and Podcast! Human Beta-Defensin3 - A Small Molecule Approach to Supressing Inflamation
BVDV Variability: Impact on Virulence, Host Range and Control
Detecting and Controlling BVDV Infections
Pestivirus Infection in Swine--Impact, Detection, Prevention and Control
NADC First International Virtual Conference on Infectious Diseases of Animals
|ARS Researchers Develop Strategies to Stop Tuberculosis Infections in Cattle
|Sep 09, 2013
|ARS Researchers Develop Strategies to Stop Tuberculosis Infections in Cattle
|Sep 09, 2013
|Identifying Johne's Disease with Accuracy
|Apr 01, 2013
|Identifying Johne's Disease with Accuracy
|Apr 01, 2013
|Treating Mastitis in Dairy Cattle with Vitamin D
|Jun 18, 2012
|Vaccine Protects Against Leptospirosis
|Jan 30, 2012
|Researchers Uncover Genetic Link to Cattle Diseases
|Sep 08, 2011
|Dietary Yeast Extracts Tested as Alternative to Antibiotics in Poultry
|Apr 14, 2011
|Scientists Named to USDA-ARS Science Hall of Fame
|Sep 15, 2010
|Scientists Counter Brucellosis Threat to Livestock and Wildlife
|Jul 15, 2010
|Model Developed for Manipulating Vitamin D Levels in Calves
|May 25, 2010
|New Vaccines May Help Thwart E. coli O157:H7
|Dec 17, 2009
|Effective Communication Essential for Pathogens that Need to Succeed
|Aug 18, 2009
|Avian Bacterium More Dangerous Than Believed
|Jun 18, 2009
|Coordinated Pushback Could Help Contain Bovine Bacterial Diseases
|May 14, 2009
|New Techniques Developed for TSE Testing
|May 06, 2009
|New Bacterial Species Named after ARS Scientist
|Mar 05, 2009
|Growing corn in Upper Plains: Can management help?
|Aug 13, 2008
|Here's the Beef: Identifying DNA Markers and Traits
|Aug 05, 2008
|New Swine Flu Has Avian Flu Genes
|Dec 19, 2007
|ARS research included in the Ag Progress Days in Pennsylvania.
|Aug 07, 2007
|New USDA Animal Research Facility Dedicated
|Jul 03, 2007
|USDA Researchers Evaluate Prion-Free Cattle
|Dec 31, 2006
|Dr. Steve Garczynski Hired By YARL
|Nov 15, 2006
|New Scientist
|Oct 03, 2006
|Scientists "Go Ballistic"Against Brucellosis
|Jun 05, 2006
|Microbes Strengthen Inside Animals' Protozoa
|Feb 02, 2006
|HOOF-Prints Help Find Where Outbreaks Begin
|Jan 20, 2006
|New Approaches Needed To Fight This Cattle Virus
|Jan 10, 2006
|Sequencing Vital in Developing New Tests for Johne's Disease
|Sep 19, 2005
|Johanns Announces Expansion of BSE Research Program and Research Initiative to Improve Food Safety
|Mar 18, 2005
|New Issue of Healthy Animals Now Online
|Mar 10, 2005


text:
SANTA CLARA -- Former Santa Clara and Earthquakes star defender Ryan Cochrane has been named a Broncos' assistant, the school announced Thursday.
Cochrane, who played in San Jose in 2008-09, helped led Santa Clara reach the 2003 College Cup. He played professionally for nine years, including winning two Major League Soccer titles with the Houston Dynamo.
"There is no doubt Ryan is going to help this program grow and become better," Santa Clara coach Cameron Rast said in a statement. "First and foremost, his background as a player is exceptional. He just finished up his professional career ... so it's a natural fit."
Cochrane served as an assistant coach at Trinity University in 2012 and at Wheaton College in 2011.
Contact Elliott Almond at 408-920-5865 and follow him on Twitter at twitter.com/elliottalmond


text:
News 12 at 11 o'clock / Friday, Nov. 23, 2012
AIKEN, S.C. -- Forget the Black Friday stampede. In Aiken, Small Business Saturday is the trend.
"A lot of people will tell us, 'I'm buying all my Christmas presents downtown Aiken, and I'm not going out of town or I'm not shopping online,'" said Sallye Rich, the co-owner of 3 Monkeys in downtown Aiken.
Her business sells holiday decorations and even some clothes and other items. Business was already booming at 3 Monkeys downtown Friday afternoon.
"Aiken is so supportive of downtown. We know we have a jewel. There are very few towns our size that have a downtown as active as we do," Rich said.
Hundreds wandered through other shops downtown, too, and there are plenty of good deals to go around.
"We are going to do 20 percent off all of our Christmas items," said Rich, adding that some other items are 50 percent off.
At Lionel Smith, Ltd., across the street, each additional item bought will be an additional 10 percent off for up to five items.
"We really try to concentrate on this time. We really try to make sure everything is right," said Van Smith, the owner of the store that sells men's clothing and suits.
Smith says it's so important to get cash flowing this time of year. They do about 20 percent of their business in this quarter, and for a lot of businesses in Aiken, that percentage is even bigger.
"It's probably getting close to 50 percent of our yearly sales will come in this fourth quarter," Rich said.
"60 percent of my business runs through this quarter," said Mary O'Hare, who owns M.B. Jewelry And Beads.
O'Hare spent Friday afternoon setting up a display outside her storefront, which includes fake snow and a snowman that blast out more fake snow. She's says it's all part of attracting shoppers to her bead and jewelry store.
"You know, you can come downtown with a $20 bill, and you can get a very nice gift for someone, and you can even have lunch all out of that $20. And guess what, you get change back," she said.
O'Hare says besides the boost to business, the community gets a shot in the arm. Sixty-eight cents of every dollar stays right here in this community.
Karen Mills, administrator of the Small Business Administration, says about 100 million people shopped locally on Small Business Saturday last year. They hope to see that number go up even more this year.


text:
Mississippi State head women's basketball coach Sharon Fanning-Otis announced Monday her intent to retire from her current position at the close of the 2011-12 season. Following the current campaign, she will move into an athletic development position in the Bulldog Club.
Fanning-Otis has produced a 608-457 record during her 36 years as a collegiate head coach. She served as head women's basketball coach at UT-Chattanooga, Kentucky and Mississippi State. She is the all-time winningest women's basketball coach in Mississippi State history with 281 victories, becoming just the 14th Division I head women's basketball coach to amass 600 career wins earlier this season.
"I want to thank Mississippi State for the opportunity and experience it gave me to be the women's head basketball coach and for the past 17 years," Fanning-Otis said. "I look forward to working in the Bulldog Club in a fund-raising capacity for all our sports. I especially want to thank all of the coaches, players, staff and fans for the tremendous experience. I am blessed to have been a part of the growth of women's basketball over the past 37 years."
A 1975 graduate of UT-Chattanooga, she served her alma mater as Coordinator of Women's Athletics, head volleyball, and head women's basketball coach during her 11 years. She was inducted into the Tennessee-Chattanooga Athletic Hall of Fame in 1993. Fanning-Otis was head women's basketball coach at Kentucky from 1987-95, winning a WNIT Championship in 1990 and advancing to the NCAA Tournament the following year.
During her coaching tenure at Mississippi State, she has directed the Bulldogs to 11 postseason appearances, including six NCAA Tournament berths and the school's only women's basketball Sweet 16 appearance. Ten of her Bulldog players earned first-team All-Southeastern Conference recognition and two players were named Kodak All-American a collective five times.
Fanning-Otis was named the SEC Coach of the Year in 2000 after leading her team to the championship game of the SEC Tournament.
During her tenure, she has served on numerous NCAA and WBCA committees, and she was named MSU's Outstanding Professional Non-Faculty Woman Award by the President's Commission on the Status of Women in 1999.
"I want to thank Sharon for her devotion to our women's basketball program for nearly two decades and for the accomplishments she has guided our program to during that time," Director of Athletics Scott Stricklin said. "She has a great heart for people, and her work ethic and dedication to Mississippi State has taken our women's basketball program to successes never attained prior to her arrival. The timing of Sharon's announcement gives us the opportunity to begin looking for our next women's basketball coach. As always, we'll identify a hard-working, intelligent coach who can move this program forward."


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- Oakland BART shooting: Full coverage
OAKLAND — Minutes before Oscar Grant III was killed by a BART police officer, the 22-year-old was in a "scuffle" with another passenger as both rode on a crowded Dublin-bound train early Jan. 1, a friend of Grant's testified Tuesday.
The scuffle, Jamil Dewar said, occurred after the passenger's son was called a name by someone in Grant's group of friends, which sparked a wrestling match between Grant, of Hayward, and the passenger. The scuffle, however, lasted only seconds before Dewar and another friend grabbed Grant to break it up — just as the crowded train of revelers glided into the Fruitvale BART station, Dewar said.
It was that scuffle that prompted more than a half-dozen BART officers to storm the Fruitvale station and force Grant and his friends from the train and onto the platform. It also was that scuffle that eventually led to Grant's death at the hands of former Officer Johannes Mehserle, who is charged with murder for shooting Grant while he lay prone on the Fruitvale station platform.
Dewar, 16, refused to call the interaction between Grant and the passenger a fight, instead calling it a wrestling match and scuffle. Dewar said that although it had ended as the train reached the station, the passenger kept yelling at Grant to get off the train and continue the brawl.
"The guy was saying to Oscar, 'Wait till we stop. Wait till we stop,'"" Dewar said. "Oscar got out of the train. The other guy did not."
Dewar said he and another friend got off the train as well and immediately noticed a BART officer with an angry face, either running or walking fast toward them. Dewar said he and his friend jumped back on the train as the officer approached with a Taser pointed toward the crowd.
"He looked pretty angry toward us. He was walking toward us with the Taser pointed at us," Dewar said. "He said, 'Get out of the train. I know who you are.' He was saying, 'Get the (expletive) off the train.'""
It was at that point, Dewar said, that his friend took a step toward the door and was "aggressively" grabbed by the officer.
Eventually, Dewar walked onto the platform, as well, and began to record his five friends, including Grant, as they sat against the wall at the station with BART officers standing over them. Dewar never captured the moment when Mehserle shot Grant, but the shot was heard on the video, followed by Dewar screaming at the police.
Dewar's video was the last of three presented by deputy district attorney David Stein at the preliminary hearing Tuesday. Stein is trying to convince a judge that he has enough evidence against Mehserle to put the former officer before a jury on charges of murder.
While Dewar's video was the most blurry of the five shown in the case, two other videos presented as evidence Tuesday were the clearest, with one showing the flash of Mehserle's gun firing.
Daniel Liu, of Dublin, earned $1,000 from KTVU-Channel 2 for the video that showed the gun go off, he said in court Tuesday. Like the witnesses before him, Liu said he began to tape the events on the Fruitvale BART station platform because he felt police were abusing their power.
Liu said it appeared that at least one BART officer, Anthony Pirone, was agitated from the beginning and never seemed to care what Grant and his friends had to say after they were pulled from the train. Though Liu admitted that Grant and his friends acted "a bit fussy," he said Pirone allowed no wiggle room in dealing with them.
"They were trying to explain. "... Pirone didn't want to listen to them," Liu said. "(He was) a little frustrated."
Liu said everything appeared calm until Grant, who was sitting next to his friends against a wall, stood up and appeared to say something to the officers. Immediately, Liu said, Pirone and Mehserle moved toward Grant and tried to handcuff him.
"Oscar Grant did not look like he was resisting, but I remember clearly that Oscar Grant's left arm was moving up and down," Liu said. "I didn't know if he was resisting or what."
At that moment, the video showed, Mehserle grabbed his gun with his right hand, stood up, placed both hands around the gun and fired. After the shot was fired, Liu said, Mehserle looked shocked.
Another witness, Tommy Cross, who also recorded the shooting, said Mehserle said, "Oh, my God. Oh, my God," after he fired the gun.
Mehserle's attorney, Michael Rains, will begin calling witnesses today. Stein rested his case Tuesday. Once both sides are finished presenting evidence, Alameda County Superior Court Judge C. Don Clay will decide if there is enough evidence to put Mehserle before a jury on charges of murder.


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HERKIMER � Depression is not a normal part of aging, according to the Herkimer County Office for the Aging.
Depression is a medical condition that can be successfully treated, according to the OFA.
Symptoms of depression are depressed mood, loss of interest or pleasure in activities, disturbed sleep, weight loss or gain, lack of energy, feeling of worthlessness or extreme guilt, difficulties with concentration or decision making, noticeable restlessness or slow movement and frequent thoughts of death or suicide or attempt of suicide, according to the OFA.
Depression is often under recognized and under treated in older adults, according to the OFA. Some risk factors can increase the chance of depression in an older adult such as chronic illnesses, progressive and disabling sensory loss, history of recurrent falls, sleep disturbances, medication side affects, alcohol or prescription misuse, prior depressive episode or family history of depression, extended and long bereavement, cognitive impairment or dementia, stressful life events, according to the OFA. If you or someone you know has any of the symptoms above seek a depression screening from your medical provider, according to the OFA.
For more information on depression go to the Substance Abuse and Mental Health Services Administration website at www.samhsa.gov or call their toll free number at 1-877-726-4727.
Or call the Office for the Aging at 867-4145.
Location, ST | website.com


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Wilkes County deputies are investigating a man's death as a homicide.
Richard Baxter Davenport, 59, was found dead around 9 a.m. Tuesday inside his home on Byrd Ridge Road in North Wilkesboro.
Davenport died of a cut to the vein, said Sheriff Chris Shew.
A family member had gone to the home and first discovered Davenport's body, Shew said.
Deputies released no other information, citing the ongoing investigation.


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Celebrate this Veterans Day
Published: Saturday, November 10, 2012 at 9:52 p.m.
Last Modified: Saturday, November 10, 2012 at 9:52 p.m.
As I write today, Oct. 29, a storm is raging on the East coast of our America. We watch and pray for all those in harm's way.
Today, the TV is reporting constantly of the coming and the already-here storm conditions.
The harm's way always reminds me of our U.S. troops who are in harm's way, in combat, protecting our American freedoms.
This reminds me of that odd but true saying, "Freedom is never free."
When the word soldier is used, it means all branches of our military who have served and are presently serving our America in its uniform — all who have served, and especially those who have given their all, in defense of our American freedom.
My thoughts now, as always, are with our American infantrymen, the combat infantrymen.
This is the soldier, the "ground pounder." The one who faces the enemy on the ground. The soldier who wears the "CIB."
This represents the combat infantry soldier, one who has been there on the ground facing the enemy soldier.
Very few get the praise they should, regardless of all the other medals awarded. The combat infantryman is our first line of defense in any combat situation.
It takes a dozen other support troops to support one combat infantryman.
These support troops are also important in every way.
These troops in direct support are the mess, cooks, mechanics, medics, supply.
All are needed to make a complete and functional combat unit.
On this Veterans Day USA, we thank all of our American veterans, and to be sure to thank all who are serving our country America today, especially those who are serving today and are in harm's way.
We hope, pray they all will return safely and soon.
"We elect leaders not to rule but to serve," said Dwight D. Eisenhower.
I concur.
God bless our great nation, America.
Jack L. Daniels
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Autism in the News – Tuesday, 04.27.10
Help sought locating missing man with autism (Venice, Fla.)
The Sarasota County Sheriff's Office is asking for the public's help in locating a missing man who suffers from autism. Read more.
Measured doses of fact, friction in 'Vaccine War' (Boston.com)
There are no bad guys in "The Vaccine War,'' no hiss-worthy villains who make it easy to decide which side we're on. Read more.
Psychiatrist says Odgren not delusional (Woburn, Mass.)
After weeks of gruesome testimony and assertions of insanity, a state-certified psychiatrist told jurors yesterday that John Odgren was well aware of his actions and the consequences when he fatally stabbed a fellow student in the boys bathroom at Lincoln-Sudbury Regional High School three years ago. Read more.
Student fights to overcome autism (The Rocky Mountain Collegian)
By all appearances, Patrick McCaffrey seems like your average CSU student. He has a girlfriend, is a freshman having fun in the dorms and is adjusting to college life. Read more.
Child Health Director Has Background in Genetics (NYT.com)
Dr. Alan Guttmacher, a Harvard-trained geneticist and pediatrician, is the new acting director of the National Institute of Child Health and Human Development, the federal agency that finances research into child and maternal health. Dr. Guttmacher, 60, previously worked with Francis Collins on the Human Genome Project and then as the deputy director of the National Human Genome Research Institute of the National Institutes of Health. We spoke for three hours in his Bethesda, Md., offices and then later by telephone. An edited version of the conversations follows. Read more.
Autistic Surfer Clay Marzo Masters Waves but Struggles on Land (ABCNews.com)
When pro-surfer Clay Marzo rides the waves off Maui's coast, it's hard to imagine that a man so gifted in the water could struggle so much on land. Read more.


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Visitor area at Chimney Rock State Park to close for road repair project
Published: Monday, February 3, 2014 at 10:36 a.m.
Last Modified: Monday, February 3, 2014 at 10:36 a.m.
The Chimney Rock Access at Chimney Rock State Park will be closed beginning Tuesday, Feb. 4 for up to three weeks as repairs are made to the main entrance road, according to a release from the N.C. Division of Parks and Recreation.
This closure affects the Chimney Rock spire and its elevator access, the Outcroppings Trail and all other visitor facilities in the vicinity.
In May, a 75-foot section in one lane of the road collapsed during a period of heavy rainfall. A contractor will be replacing a retaining wall that supports this section of roadway near the park entrance.
After a 21-day construction period, single-lane access to the park will be available as road repair continues.
However, throughout the construction period, the park's Rumbling Bald Climbing Access will remain open.
For more information, contact the park office at 828-625-1823.
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