text:
The Maternal Anti-Fetal Brain Antibody Story – where are we now?
We have asked several scientists who gave presentations at the April 10-11 DAN! conference in Baltimore to share their research and perspectives from the meeting with you here on the blog. The following piece is from Judy Van de Water, Ph.D. Professor of Rheumatology, Allergy and Clinical Immunology, Department of Internal Medicine and The M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders) at the University of California, Davis. Dr. Van de Water's laboratory research programs include the identification of the various mechanisms associated with autoimmune and other immune-mediated disorders. Dr. Van de Water is currently part of the NIEHS funded Center for Children's Environmental Health as the principal investigator of the Immunological Susceptibility in Autism project. She is also part of a project funded by NIMH in collaboration with an epidemiologist at Kaiser Permanente to examine the plasma of mothers whose children have autism for early biomarkers.
I am extremely fortunate to have been involved in a research project that has provided such rich and satisfying results at this point in my career. We have spent the past few years working on the identification and characterization of antibodies in the blood of mothers that recognized fetal brain proteins. We have found that these specific antibodies are associated with autism in about 13-15% of cases. It has been a bumpy path at times, but the hard work and diligence of the individuals in my laboratory that actually do all of the work, has been worth it.
What are autoantibodies?
The immune system is charged with identifying and destroying unwanted assailants. It is made up of a complex network of specialized cells and molecules that patrol the body seeking out intruders. In order to defend us, the immune system must be able to distinguish between self-tissues and foreign invaders. In healthy individuals, the immune system will mount responses to unfamiliar objects only, and ignore the body itself.
Sometimes this identification system breaks down, and the immune system mistakenly targets the body's own tissues. This phenomenon is known as autoimmunity, and is observed in diseases like lupus, rheumatoid arthritis, myasthenia gravis, and multiple sclerosis.
A major weapon used by the immune system to protect the body is a group of proteins called antibodies. Produced by highly specialized white blood cells, antibodies work by attacking unwanted invaders, and letting other immune cells know that there is an intruder that needs to be destroyed.
Self-directed antibodies are called 'autoantibodies', and are a major contributor to the destruction observed in autoimmune disorders. In autoimmune disorders, antibodies may be directed against various building blocks of the body like DNA or neurons.
From the Beginning…
The first suggestion that maternal antibodies might be involved in autism came from early studies showing that antibodies from mothers of children with an autism spectrum disorder reacted to proteins on lymphocytes (a type of white blood cell) from their affected children. Given that antigens expressed on lymphocytes are also found on cells of the central nervous system, the authors proposed that aberrant maternal immunity might be associated with the development of some cases of autism [1]. More evidence of a link between maternal immunity and autism came from the study of one mother whose antibodies reacted to adult rat cerebellar Purkinje cells. Furthermore, when these antibodies were injected into pregnant mice, the offspring exhibited some behavioral abnormalities [2]. It was subsequently shown that plasma from several women whose children had autism contained antibodies that recognized proteins in fetal rat brain [3].
Most recently, we identified a highly specific pattern of autoantibody reactivity to fetal human brain proteins in the serum of mothers who have a child with autism [4]. This work by my graduate student, Dan, was awarded the very prestigious honor of being named among the Top 10 Research Achievements of 2008 by Autism Speaks, and a mention again in 2009. Our colleagues, Harvey Singer and Andrew Zimmerman at Johns Hopkins University and the Kennedy Krieger Institute [5] also reported similar findings, which helped to confirm our work. In addition we demonstrated that similar antibodies exist in pregnant women whose children were subsequently diagnosed with autism in a study with our colleague Lisa Croen at Kaiser Permanente [6]. It is important to note that in this case the samples were collected during pregnancy, while in the other cases the samples were collected after the child was born and diagnosed. This may lead to the possibility of diagnosing autism at a much earlier age than is currently possible.
Compelling data linking these maternal antibodies to a potential role in autism come from antibody transfer studies in primates. Briefly, antibodies (purified from women with multiple children with autism) were injected into pregnant rhesus monkeys, and the pregnancies were allowed to continue to term. The resultant offspring showed dramatically altered behaviors including hyperactivity, repetitive behavior patterns, and impaired social interactions, not unlike symptoms seen in children with autism. A similar study has now been published using a mouse model, with analogous results: offspring that were exposed in utero to antibodies taken from mothers of children with autism had a number of behaviors consistent with those seen in children with autism [7]. Collectively, these studies suggest that in at least some cases of autism, circulating maternal antibodies directed against certain fetal brain proteins might cross the placenta and bind to targets in the developing fetal brain. These antibodies may interfere with fetal neurodevelopment, potentially leading to neurodevelopmental disorders such as autism.
How can these brain-reactive antibodies affect the developing fetus?
During pregnancy, antibodies are passed from the mother to the developing fetus. These antibodies have a protective role, serving as a temporary immune system until the child's own system matures during the first year of life.
If autoantibodies are present in maternal circulation, the fetus will receive them as well. Autoantibodies passed from the mother are capable of reacting with targets in the body of the developing fetus (see diagram). In some autoimmune disorders, including lupus, rhematoid arthritis, myasthenia gravis and Grave's disease, autoantibodies produced by the mother can have a damaging or altering effect on the developing fetus.
So, where are we now?
The above observations suggest that detection of antibodies directed against fetal brain proteins may in the future serve as valuable biomarkers to identify women who have an increased risk of having a child with autism. It is anticipated that the presence of these antibodies would identify those women who are at particularly high risk for having a subsequent child with autism. Therefore, the primary goal of our current work is the identification of the proteins that the maternal antibodies recognize. Therein lies a more difficult task. I recently presented an update of this work in a science session at the DAN! meeting in Baltimore. It was a wonderful experience, with a full audience and lots of great questions following the presentations. Many of the researchers in the field feel that bringing the most recent science to the DAN! community is important, and we value our interaction with the families and practitioners at the conference. During my session at the April 2010 meeting, I presented our more recent studies through which we are working to identify the proteins recognized by the maternal antibodies. While we have identified two of the proteins, the third remains frustratingly elusive. However, we are confident that we will eventually get it, thus allowing us to design a better test for these antibodies. Unfortunately, we do not yet know what causes these antibodies to be made. We are working on what triggers the immune system of some women to produce these antibodies to brain proteins. Another thing to keep in mind is that the antibodies are associated with only 13-15% cases, and there are lots of other causes of autism. Finally, we hope that through the identification of the targets for these antibodies, we can someday provide a therapeutic to those individuals who have the antibodies, and wish to have more children while potentially reducing the risk that their next child will also be on the spectrum.
1. Warren, R.P., et al., Detection of maternal antibodies in infantile autism. Journal for the American Academy of Child & Adolescent Psychiatry, 1990. 29(6): p. 873-7.
2. Dalton, P., et al., Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol, 2003. 53(4): p. 533-7.
3. Zimmerman, A.W., et al., Maternal antibrain antibodies in autism. Brain Behav Immun, 2007. 21: p. 351-357.
4. Braunschweig, D., et al., Maternal serum antibodies to fetal brain in autism. Neruotoxicology, 2008. 29: p. 226-231.
5. Singer, H.S., et al., Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol, 2008. 194(1-2): p. 165-72.
6. Croen, L.A., et al., Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry, 2008. 64(7): p. 583-8.
7. Singer, H.S., et al., Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. J Neuroimmunol, 2009. 211(1-2): p. 39-48.
I want to thank everyone for their interest in our work and for their responses and questions regarding the research presented in the AS blog. I thought that I would take this opportunity to clear up a few things and answer some general questions. First, and foremost, we do not know at this time what causes someone to start making antibodies to fetal brain proteins. While we know from research on other autoimmune diseases that some individuals are more susceptible to breaking tolerance to self-proteins, we don't know the cause for most autoimmune disorders.
We are investigating one gene that we think may contribute to the susceptibility to make these antibodies, but the work is still too early to report. However, there is not likely to be just one cause, just like there are multiple ways that a child can develop autism. I would also like to stress that while it is true that the tendency towards getting an autoimmune disease can be inherited, we still cannot predict who will ultimately become affected. What we now know about autoimmune disorders in general is that there is likely a genetic susceptibility combined with an environmental 'hit' of some kind, which can include infectious agents, certain medications, and/or toxicants, that pushes the immune system past its regulatory mechanisms thereby resulting in loss of tolerance to self. The majority of the time, this occurs long before an individual shows signs of an autoimmune disorder, making it very difficult to determine the inciting factor. So while we know that in a subset of cases maternal antibodies to fetal brain proteins may play a role in changing neurodevelopment, we may never know what the trigger is that causes the generation of these antibodies. But, we will keep working on it!!
Finally, for all of you who are interested in participating in our research, please contact me and I will get your contact information.
Thank you all again for your generous support of our work, and for sharing your stories with me. I learn so much from each of you.
April 19, 2010 at 4:45 pm
Would ulcerative colitis fit into the list of auto-immune disorders that could result in these autoantibiodies?
This is facinating and amazing research, thank you!!!!
Finn's mom
April 19, 2010 at 4:56 pm
Good Afternoon! Need any volunteers for blood testing? My son has Aspergers. I have said for years that the DNA link had to be their. He is now 23 years old. I am certain, knowing the checlist like I do that my son, possibly myself, my father and my uncle (fathers brother) has had some form of autism. Please let my son and I know what we can do to help. I also have another son who has none of these issues. I was told when I was pregant with both boys that I have extremely high antibodies, which might account for why I now have trouble with my immune system in the form of allergies. Please let us know. thank you
April 19, 2010 at 5:39 pm
Our daughter who is almost 3 years old received an Anne Connolly test and tested positive for IgG autoantibodies and another autoantibody that indicate brain inflammation. Are there any suggestions for treatment that may help her?
April 19, 2010 at 6:04 pm
I have always thought there might be a connection with Autism and the immune system. I have a Granddaughter that started loosing skills & speech at 3 yrs. of age. Both of her Grandmothers (maternal & paternal) have severe Rheumatoid Arthritis. My daughter, her mother, also develops hives and other allergic reactions to many things. I think those that have a compromised immune system are more prone to environmental factors that may trigger Autism. I mentioned this to a Neurologist we took her to in 2002 – and he was very dismissive. I am so glad this study is finally being taken seriously. Please keep us posted. Thank you.
April 19, 2010 at 7:00 pm
I wondered is there a way I could get tested? I would be more than willing. I have a 14yr old girl who is autistic and would love to know if this is what happened.
April 19, 2010 at 8:32 pm
My son will be 2 1/2 at the end of May and he got his autism diagnosis from Children's Boston December 2nd, 2009. We have had him in Early Intervention services since he was 12 months old and now receives 15 hours of autistic tutoring weekly ontop of his E.I. services. Life is busy!
I find this article interesting and often question if my body had something to do with him being autistic. When I got pregnant I was 155ish pounds (healthy) but developed gestational diabetes around 25 weeks gestation. I controled my sugars with diet and exercise. I was also diagnosed with PCOS at the age of 15. He was born at 37 weeks and I was put on Pitocin to start my labor after my water broke the day before. 5 hours later we had a beautiful baby!
I know first hand what its like living with PCOS and for having delt with diabetes for a short while…what that could have done to him while he was "cooking," makes me wonder if that could have caused the autism? I will also note that besides my daily viatimns, I took no other medications during pregnancy and consumed no alcohol and have never touched drugs in my life time.
Any ideas on this would be great! I would also be up for some testing if need be for research purposes.
April 19, 2010 at 9:50 pm
Wow – this is interesting stuff. There is a long line of autism in my family from both sides so there's no doubt something is being passed along. What is strange is that my ex-husband has multiple sclerosis. I wonder if that played into the soup that made up my son……. My daughter is not on the autism spectrum although she has a pretty low processing speed.
April 20, 2010 at 1:38 pm
I do believe autoimmune issues are causing a host of problems in the world today, that perhaps were not so prevelant in the past, or were much more mild. I have a family history and so does my husband of endometriosis which I believe has an autoimmune system problem at the root cause. I would be able to believe that one thing leads to another with the fetus having autoimmune issues when the Uterus, and the genetics show predispostion to autoimmune issues. WHY….allergies, autoimmune issues, and there derivitives are on the rise? It would seem it might be the enviroment as a large contributing factor. We now frogs grow extra body parts, and their offsprig do as well when living in a polluted pond. We live on a pulluted planet therefore we are having autoimmune sensitvities show up in places similar to the frogs in the pond. So who is to blame? Who is allowing for so much pullution to enter the environment of the people and the frogs. How do we change it? How do we cope with it as altered biological organisms? Or is this the future…we will all be autistic and are bodies will be fighting the environmental problems interenally seeing no one wants to fight them externally. It will be expensive? Yes, expenisve to all and everything on the planet. Good research….keep searching, what do we do now? Therapy and pain management for all those effected on a autoimmune suffering environment, how about better methods to pay for it all, in order to keep the species alive and coping!
April 20, 2010 at 2:22 pm
Dr. Van de Water's research is so important. She is one of the few scientists rigorously studying autism's environmental triggers.
Autoimmune diseases run in so many families w/ ASD kids. IVIG was the intervention that helped restore my son's health, but every kid is different. What we do know is that far too few treatments exist for this population and more autoimmune intervention grants need to be funded.
There was zero autism in my family but so many autoimmune diseases. As a baby, my son could not tolerate the injection of so many viruses at once- along w/ a dozen toxic adjuvants. His adverse vaccine reactions were horrible. Kids like mine regress for a reason.
April 21, 2010 at 4:24 am
Me and my sisters? Allergies, hypothyroid (in a big way), my kid's cousins? ADHD/anxiety akimbo with asthma and allergies. My parents? Mom – allergies and very serious bowel problems. Dad – Huge allergies and my uncle is still resentful (at 84) re: all the attention my father received as a child as he was always so sickly. My husband's family – He's covered in rashes daily of all sorts. But, "he's healthy" – yeah right. His mother? Hypothyroid as well.
Both of my pregnancies with my two children are VERY significant (but will remain private). Both were very damaged by their very different gestations for very different reasons.
But, of course this set my first son up in a big way – he reacted and couldn't process a host of issues thrown his way – antibiotics, vaccines (he has a scar from one of them), culminating in me SCREAMING from the bottom of my very being when my belief system was shattered – when he received his flu shot post 2 years old – even daycare, who had been telling me I was crazy, that he was fine – even they were terrified. So my first kid is clearly both – ASD from birth and vaccine damaged.
My second kid – NT w/issues and sadly will remain vaccine free for now (I'm NOT happy about this – but cannot split up the vaccination schedule, as it is simply not available where I live. I'll start when he's ten years old).
Oh – and did I mention I live in one of the most polluted cities? Love that EARLI study!
April 21, 2010 at 2:30 pm
My 3 1/2 year old son is in the Autism Spectrum. I have history of Lupus and so does my mother. Are you stating with your research that because of my Lupus I have a son with Autism?!?!?!
April 21, 2010 at 5:04 pm
I don't know who you were asking Julie, but I'll answer. I have no idea what caused your child's autism. I would never presume to know better than a parent regarding their own child.
I think Van de Water's research is important because she has uncovered a link. There is a disporportionately high rate of autoimmune disease in families affected by autism. The theory is that when a baby inherits a genetic predisposition for a weaker than average immune system, that baby is more vulnerable to challenges to his immune system, so when he is injected w/ numerous live and preserved viruses, his autoimmune system goes into overdrive attacking itself causing cognitive and physiological damage. The result being a series of illnesses and a regression. I believe this happened to my child. Julie, I hope your son is well.
May 26, 2010 at 5:20 pm
I also think Van de Water's research is interesting. However, I would like to point out that maternal antibodies reacting to fetal antigens is NOT an autoimmune reaction because the fetus usually has a completely different set of proteins than the mother. If the mother is exposed to the fetal brain proteins alien to her, it is completely natural that she will form antibodies against those proteins. What needs to be explained is when and how the mother gets exposed. The fetal proteins do not cross the placenta.
Could anybody clarify me why the word autoimmune is used in this context at all?
February 14, 2011 at 11:23 pm
I have lupus and both my children have autism. I always thought there might be a link.
June 18, 2011 at 10:04 pm
Is it possible that some adjuvant in vaccines have, over the years dysregulated mothers' immune systems such that they produce anti-fetal brain antibodies? Maybe some complement or epitope which hasn't even been suspected causes a mother's immune system to react in a bazaar way.
Sincerely, John Scatchard
February 24, 2011 at 11:04 am


text:
"NAMI Mcpherson" will be having their monthly affiliate meeting at 7 p.m. Thursday at Crossroads Assembly of God Church, 1064 14th Avenue. The agenda for this meeting will include one a member sharing her experience with NAMI's Family to Family Program. Remaining time will be a "Share and Care" facilitated by Kate. For further information please contact me at firstname.lastname@example.com or by phone 620-755-5563.
Location, ST | website.com

subset: commoncrawl


text:
3.2 million shares of HCA to be sold
Published: Thursday, December 13, 2012 at 1:00 a.m.
Last Modified: Wednesday, December 12, 2012 at 8:32 p.m.
Staff and Wire Reports
HCA Holdings Inc., the parent of four Southwest Florida hospitals, says that some of its largest shareholders plan to sell about 32 million shares of its common stock in an underwritten offering.
HCA said the selling shareholders mainly include affiliates and funds related to private equity firms Bain Capital Partners LLC and Kohlberg Kravis Roberts & Co. HCA is not selling any of the shares and will not receive any of the proceeds.
Tennessee-based HCA owns and operates hospitals and a variety of other health care facilities across the country. As of Sept. 30 it ran 162 hospitals and 112 free-standing surgery centers.
HCA owns Bradenton's Blake Medical Center, Doctors Hospital in Sarasota, Englewood Community Hospital and Fawcett Memorial Hospital in Port Charlotte.
The company's shares have risen steadily this year, gaining about 50 percent so far. Last month, it reported a profit of $360 million, or 78 cents per share, reversing a loss in the same period the year before. Revenue increased 11 percent to $8.06 billion.
The company's shares were selling for $32.91 at the close of regular trading on Wednesday, down 7 cents.
This story appeared in print on page D3
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
|Related Links
|Sumitomo Catalog
Sumitomo Wiring Systems (Manufacturing code: SUM) is a leading supplier of interconnect products for the automotive and transportation industries. Sumitomo took its first steps as a company in 1917 when Japan was riding a wave of industrialization. Sumitomo began by producing power cable, telephone wire, wire harnesses for motorcycles and automobiles and has been a significant player in technological developments in transmitting power and data in the industry.
|Sumitomo Connectors – Sealed & Unsealed
|Sumitomo Terminals – Wire Gauge Range: 0.22mm to 10.0mm
|Sumitomo Cable Seals & Plugs
|Sumitomo Harness Clips & Clamps
For additional information or a quote, our Transportation Business Unit team stands ready to assist.
TTI Inc. Transportation Business Unit
Phone: 1-877-884-4288 (1-877-TTI 4-AUTO)
Fax: 1-216-750-9642
Email: email@example.com


text:
Texas A&M - Corpus Christi men's tennis senior Laurent Montoisy received yet another honor on Wednesday after being named to the Southland Conference Men's Tennis All-Academic team. The honor is the second of his career and he was an automatic selection after being named the Player of the Year in the league.
The top Islanders player this past season excelled both on the court and in the classroom. He held a 3.01 GPA in finance through this past year and it is his second time on the team after being named to the 2009 team as well.
The native of Lasne, Belgium finished his Islanders career with a record of 17-2 against Southland Conference opponents and was a two-time First Team All-Southland member as well as a second team selection during his freshman year. He was named both the Freshman of the Year and Player of the Year during his career.
After a 5-1 mark in Southland play and a second team all-conference honor at No. 1 singles, Montoisy received the 2008 Freshman of the Year award from the league.
In 2009 he was named first team all-conference at No. 3 singles and No. 2 doubles as he helped his team to a second-straight regular season and tournament championship as well as an appearance in the NCAA Championships.
Montoisy redshirted during the 2010 season before coming back for his senior season in 2011.
This past season he was undefeated in singles matches against league competition while being named First Team All-Southland at No. 1 singles and received the Player of the Year award. He led his team to yet another regular season and tournament title and their third NCAA appearance in four years. He was also named the league's Player of the Week four times during the year.
He received the Player of the Week honor a total of six times in his career. Overall, he finished with a 38-18 career record against some of the toughest competition in the nation.


text:
- Feb 13:
- Dana Milbank: Let the bleak times roll
- Feb 12:
- State of the Union 2013: Analysis: President Obama isn't in the mood for compromise with GOP in Congress
- State of the Union 2013: GOP warns President Obama against tax increases, spending
- Oakland Tribune editorial: Effective State of the Union speech and response should set tone
- Contra Costa Times editorial: Effective State of the Union speech and response should set tone
- State of the Union 2013: Obama: Nation stronger, GOP should back his plans
- State of the Union: Obama's address framed by second-term legacy
- State of the Union squatters: Lawmakers wait hours for aisle seats
WASHINGTON (AP) -- Florida Sen. Marco Rubio's Republican response to President Barack Obama's State of the Union address included an impromptu water break to quench his thirst.
Rubio appeared to wipe away sweat during his rebuttal from the Speaker's conference room in the U.S. Capitol shortly after Obama's address. At one point, Rubio reached out with his left hand and took a quick swig of water from a small Poland Spring water bottle.
The brief sip of water lit up social media outlets such as Twitter, with people commenting on Rubio's thirst.
Garrett Jackson, Mitt Romney's personal aide during his 2012 presidential bid, tweeted that he "would have had that water bottle closer, had it been the Gov. Haha. Marco needs an aide."
Rubio tweeted a photo of the water bottle.


text:
HONESDALE- PennDOT, Northeast Highway Safety, Buckle Up PA and Honesdale Police Department will have a Safety Information Check from 11:30 a.m. to 12:30 p.m. in front of the Honesdale Police Department 962 Main St, Honesdale. PA on Wednesday, July 16, 2014.
The safety information check is being held to inform the public about key safety issues when driving such as wearing a seat belt, no texting and driving and other related safety issues.
Location, ST | website.com


text:
If there is an error when sending the mail,
use your back button on yout web browser and correct the error.
Friend's E-mail:
(maximum of 3 addresses separated by commas)
Your E-mail:
A Brief Comment (150 char max / 25 word max)
Girls Strike Zone: Webisode 5
With Mike Barger and Kyle Brennan
Security image:
(Case sensitive)
the e-mail sent will contain information, such as your IP address (
), for purposes of tracking abuse. Use of this software to spam or harass individuals can and may result in penalties punishable by law.


text:
Szechwan wrote: So you get ASMR then?
I do. I wish everyone did. It's like a cheat code for life. Stress? Insomnia? Bam. No drugs required.
I do recognize that it'd be weird as fuck from an outsiders perspective though.
Mark in Minnesota wrote: Experiments have proved that acclaimed experts with wine don't know wine when they taste it absent typical cues such as label, bottle, glass, temperature, color, scent.
Experiments have proved that acclaimed experts with wine engage an entirely different brain neurology that you and I when tasting wine that has been properly presented, poured, etc.
Mark in Minnesota wrote: Anyone who has studied neural networks for even a little while finds these two observations perfectly compatible. Perception -is- reality for the trained thinker.
All pain is relative to the brain subjectively experiencing it.
Why not the same with pleasure, even the ecstatic degrees?
Mark in Minnesota wrote: My own experience with this stuff is that my existing frisson reactions to music sre tenfold stronger since I started experimenting with ASMR triggers. I almost cried listening to El-P the other day. El-P. You know, the Brooklyn melonhead with too many sci-fi influences and all those daddy issues. I almost wet myself.
That's a feedback loop of existing senstion plus awareness of sensation. Neural pathways reinforce themselves with repeated use, and some of those have synergy with actual chemical sensations like dopamine release. This is why Pavlov's dogs salivated when a bell rang, it's why mommy is a slot jockey now, and it's an adeuqate explanation of why putting a name on this thing and seeking it out will strengthen (and, to a certain extent, supplant) the basic sensation.
Wetware isn't bugfree and most of its circuitry is emergent through use. At least that's my understanding.
Elorza wrote: I watched that ASMR video from a while back Mark linked to-which was of course incredible-and immediately went to search for more videos...which resulted in page after page of videos of women whispering at me? I feel like I missed a few steps.
Anyway, the ASMR effect is something else. I was giggling like a fool during the matchbox sequence.
DeadAwake wrote: Basically what i think is that these "experts" are professionals in monkey business. I would like to look at some of the details of that study.
DeadAwake wrote: the main point, the overall principle is that if the body expends something it has to be recharged.
Neuro wrote:
Mark in Minnesota wrote: Every time I see one of those things I think of the Volus aliens from Mass Effect.


text:
A 14-month old toddler in Portland, Oregon managed to buy a car.
Of course, she had no idea she was doing it.
This is one of those smart-phones-gone wrong stories.
Kids can be busy-bodies.
Sorella Stoute sure is.
She loves a super-solid, crash-tested smart phone.
And car keys are pretty cool too!
So it all added up last month, when dad received notice from eBay, congratulating him on his purchase -- of a gently used, 1962 Austin Healy sprite, for just over 200 dollars.
225 is what it ended up total costing.
"She decided I think to open the eBay app, and started clicking around and one thing led to another and we own a car," her dad, Paul, said.
It's a "frankensprite" to be exact.
You can imagine mom and dad's reaction when they found out about little sorella's on-line shopping spree.
But they decided to keep it.
She can steal your heart, she's so cute.
And she got away with this stunt too.
How many 14 month olds can say they bought something online -- let alone a classic roadster with a good set of Michelins?
Dad says he'd like to restore it.
He just started a page on one of those fundraiser websites and hopes to have it in tip-top shape sometime.
Maybe give it to Sorella for her 16th birthday, or graduation.
"I've done a lot of body work in the past like Bondo and stuff like that but this is, another realm altogether, I'm just glad she didn't buy the 38,000 dollar Porsche I was also looking at," dad said laughingly.


text: Find beautiful ladies' briefs and plus size briefs that are designed to fit your figure at Bonmarché. A fabulous variety of cuts and colours to choose from in sizes 12-26, so you're sure to find the perfect style for your shape. The range includes maxi briefs, control briefs and multipacks. Feel good for less!


text:
The U.S. Fish and Wildlife Service joined with community partners across the nation to remove or bypass 158 dams, culverts and other structures in 2011, opening more than 2,180 miles of streams to native fish populations.
These efforts, coordinated through the National Fish Passage Program, have contributed to improved water quality, provided additional recreational and economic opportunities and addressed serious threats to human health and safety.
"The National Fish Passage Program serves as a vital catalyst for grass-roots community action that not only benefits native species and habitat, but also contributes to local economies and addresses aging and sometimes dangerous infrastructure," said Dan Ashe, service director. "Everyone wins when rivers and streams are allowed to flow freely again."


text:
|Equal Employment Opportunity and Education
Mission Statement
The Gainesville Location Equal Employment Opportunity (EEO) Committee is charged with developing policy and carrying out activities to increase the diversity of the workforce at the U. S. Department of Agriculture, Agricultural Research Service (ARS), Center for Medical, Agricultural, and Veterinary Entomology (CMAVE). We advise the Center director and the ARS South Atlantic Area (SAA) Office about EEO/CR concerns and prepare reports for SAA and ARS Headquarters administrators. Each year, we sponsor several career development and training activities, science outreach programs, and special observances. The committee's science education outreach activities have received community and SAA commendations.
CMAVE Student Programs
EEO Committee Members
Ulrich Bernier
Seth Britch
Heidi Burnside
Eric Daniels
Bonnie Ebel - Pres.
Nancy Fieleke
Chris Geden
Dan Kline
Kenneth Linthicum
Richard Mankin
David Oi
Barbara Soto
Jean Thomas
Dianne Underwood
Betty Weaver
Pat Whitmer


text:
1.0 OverviewEach November Boy Scouts of America sponsors a "National Good Turn" called Scouting for Food. Each Scouting unit across the country canvasses its local neighborhood for contributions of food to contribute to a local food bank. For many of our neighbors, food collected as part of this important effort will make the difference between hunger and a decent Thanksgiving.
2.0 Concept
2.1 DescriptionScouting for food proceeds on two successive Saturday mornings. On the first morning Scouts work their way from house to house in designated neighborhoods leaving a doorhanger on the front door of each house. The doorhanger advises the resident of the food drive and asks that they leave a bag of non-perishable food on the doorstep for pickup the following Saturday morning. On the second Saturday, we revisit our assigned neighborhoods and collect any food left for us. We then count up the quantities of food collected and deliver it to the Listen Food Pantry.
In both operations, Scouts are driven around their assigned neighborhoods in small teams (2-4 per car). It is important to keep track of where each team went the first week, so we can go back the second week! Each team will keep track of exactly where it went, and submit a report to the activity leader after returning from putting out doorhangers.
The following Saturday, we will use those reports to assign teams to collect donated food. On return to the community center, each team will tally up its collection and submit a report. The activity leader will use these reports to complile a final tally for reporting to the Council.
Finally, we will transport the collected food to the Listen Center in Lebanon.
2.2 Schedule of EventsSaturday Nov 2
1000 -- Meet at the Community Center, divide into teams and get assignments.
1030 -- Depart for assigned areas. Leave doorhangers on as many doors as possible.
1200 -- Return to Community Center and submit activity reports.
Saturday Nov 9
0830 -- Meet at the Community Center, divide into teams and get assignments.
0900 -- Depart for assigned areas. Collect any donations left by residents.
1200 -- Return to Community Center and submit activity reports.
Tally totals and consolidate for transport.
1230 -- Transport product to the Listen Center in Lebanon.
2.3 Expected Conditions and DifficultyThis should be a relatively easy, fun activity. Be prepared for the weather.
2.4 Special RequirementsOpen to all Scouts, Scouters, and parents. There are no skill prerequisites for this outing.
3.0 Administration and Logistics
3.1 Announcement Date: 23 Oct 13
3.2 Roster Closing Date: Oct 30 & 6 Nov 13
3.3 CostsNone.
3.4 Equipment
3.4.1 Individual Equipment
3.4.2 Patrol EquipmentNone.
3.4.3 Troop Equipment
3.5 Transportation PlanDrop-off Point: Community Center
Drop-off Time: See schedule of events
Pickup Point: Same Place
Pickup Time: See schedule of events
4.0 Leadership
4.1 Planning Committee
4.2 Adult Leaders
Approved DLM 26 Oct 13


text:
MOUNTAIN VIEW -- Pitbull is tenacious.
The Miami rapper -- whose real name is Armando Pérez -- simply refuses to leave the dance party. He kicks the groove into high from the start and spends the rest of the night sending it into overdrive.
The man who seems to be everywhere these days -- endorsing products on TV, making guest appearances on singles by other artists and pushing his own records up the charts -- brought the dance party to Shoreline Amphitheatre on Friday night.
Pitbull proved to be a first-rate entertainer who's every bit as good at selling a lifestyle onstage as Jimmy Buffett or Toby Keith. His schtick is quite attractive, offering up a dreamland where the party never stops, the hangovers don't hurt and everybody is beautiful. He sells it with his clothes, his beats and his lyrics.
And people are most definitely buying.
Friday's show, which also featured an hourlong set by pop star Kesha as well as DJ music, drew a near full house to the 22,000-capacity venue. The crowd boogied throughout the nearly four-hour show, turning Mountain View into the dance party capital of the U.S. for at least one night.
Pitbull's greatest assets onstage are charisma and energy, both of which are far stronger than his rather mediocre voice. He couldn't always carry the tune, but he always carried the show.
Backed by a seven-piece band, which included two powerful percussionists, Pitbull hit the stage in a nicely tailored black suit, matching button-up shirt and dark shades. He beamed his increasingly famous smile as he looked over the crowd, then began to race through "Hey Baby (Drop it to the Floor)," the smash from 2011's "Planet Pit."
"Do you like how it feels?" Pitbull barked as the first number came to a close.
They did. And this was an evening that was definitely more about "the feel" -- pure Miami dance club -- than any particular songs. Everything was over-the-top. And the crowd ate it up.
Pitbull occasionally provided a small degree of personal insight, such as when he talked about those who complain that he doesn't make "street music" anymore.
"I tell them, 'I made music to get out of the streets, not to stay in them,'" he said.
The roughly 80-minute set was filled with hits from throughout Pitbull's nine-year career, which has produced seven studio albums. He went back to the early days to play his first single, "Culo," and spent a good amount of time with last year's hit album "Global Warming," performing such tunes as "Feel This Moment," "Back in Time" and "Don't Stop the Party," making each tune count just as much, if not slightly more, than the last.
Kesha also proved handy at fueling a dance party during her set, which included such top hits as "Tik Tok," "Blah Blah Blah" and "Your Love Is My Drug." Perhaps the most interesting thing in her set were the dancers onstage: one was dressed up as a tiger, another as a giant beaver and still others were in bunny and rooster suits. It looked like a convention of college sports mascots doing a routine from "A Chorus Line."
Now that's entertainment.
Follow Jim Harrington at Twitter.com/jimthecritic, www.facebook.com/jim.bayareanews and http://blogs.mercurynews.com/aei/category/concerts.


text:
OAKLAND -- The Warriors played down to the level of the Washington Wizards.
That was what Warriors coach Mark Jackson said he witnessed Tuesday, and with Stephen Curry missing two potential game-tying 3-point attempts in the final minute, the Wizards came away with an 88-85 win at Oracle Arena.
"Right now, we're a team that if a championship-caliber team comes in here or an elite team comes in here, we play at that level," Jackson said. "And if a bad team or an average team comes in, then we play at that level. We are not good enough to allow who comes in here to determine how hard we play.
"We didn't play at a championship-level intensity, and that's the disappointing part. Good or great teams in this league, it doesn't matter who's on the other side."
Curry scored a game-high 23 points but was forced into an off-balance, left-handed shot attempt before the buzzer sounded as Washington celebrated a win that got the Wizards to the .500 mark.
The Warriors have lost three of four home games before the Los Angeles Clippers come to town on Thursday.
"I think we're just coming in and just thinking the crowd's going to win us a game," center Andrew Bogut said. "I don't think we're in a position like most people say we are where we can mark in the calendar who we're going to beat."
Bradley Beal scored 18 of his 20 points in the second half to lead the Wizards, helping them go on a 20-2 run after the Warriors had led in the second quarter by as many as 10 points.
The Warriors committed 19 turnovers, shot 37.5 percent from the field and were outrebounded 56-47.
"It was a bad performance and really disappointing," said Curry, who was 8 for 23 from the field and committed six turnovers.
"It seems like every night it's been something different."
Klay Thompson scored 13 points, and David Lee added 11 while struggling with a 2-for-10 shooting performance. Nene had 16 points for Washington, and John Wall added 15.
Curry hit a 3-pointer to pull the Warriors within 85-83, and Lee tied the score with a layup, but then Wall connected from long range for the go-ahead bucket.
Beal had hit three consecutive 3-pointers to give Washington a 75-68 lead in the fourth quarter, continuing the Wizards' hot shooting after teammate Martell Webster had connected from long range with 11.7 seconds left in the third.
Golden State had previously held the momentum in the third after going on a 12-0 run while Washington spent more than six minutes without a field goal.
Lee struggled mightily, starting the game shooting 1 for 8 from the field and at one point in the third quarter losing the ball three times for turnovers in the span of four Warriors possessions during the Wizards' 20-2 run.
The Warriors led 49-45 at halftime, allowing the Wizards to score the final six points of the second quarter.
Golden State got 29 bench points, including nine from backup point guard Jordan Crawford. Marreese Speights had seven points and matched a season high with nine rebounds.
Harrison Barnes assisted on back-to-back dunks from Draymond Green and Speights, with an excited Speights coming back down the court on the next possession to hit a rare 3-pointer in the second quarter.
"I haven't been able to accomplish that," Barnes said, "but as a team, we've been able to do well.
Despite seeing his shooting percentage dip from his rookie season, Barnes said he continues to feel good about his shot.
"Coming in to do work every single day, putting in the time, so I'm confident shots will go in," he said.
Thursday's game
L.A. Clippers (32-15) at Warriors (27-19), 7:30 p.m. TNT


text: The last National Lampoon movie I saw had Topanga from "Boy Meets World" on a boat that was also a school or something like that. It wasn't bad, I'll always have a special place in my heart for Danielle Fishel. But that was years ago and now apparently they've landed Neil Patrick Harris and that guy is awesome. The film is called "Dracula's Daughters vs the Space Brains" and I have absolutely no idea what it's about and for the most part don't care. There's half naked women, terrible CGI, Doogie Howser and Penn Jillette did the voice over for the trailer.


text:
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Art.com at the time of purchase will apply to the purchase of this product.
Get it today!Shop Now
OrAdd to Wish List
A Series of Strong Storms with Fierce Winds and Heavy Rains Hit California Framed Art Print by. Product size approximately 19.75 x 15.75 inches. Available at Art.com. Embrace your Space - your source for high quality fine art posters and prints.. Price: $59.99
© Copyright 2016 - Christmas.com. All rights reserved and protected by Christmas Spirit


text:
How to Set Up a PayPal Account
How to Set Up a PayPal Account
Join the millions of people using PayPal today:
- Create a PayPal account—sign-up is free
- Add your payment info
- Start using PayPal
Don't have an account?
Stay Secure and Protected
STEP 3: START USING PayPal
Sign-up is free and super easy. Choose from three PayPal account types—Personal, Premier, and Business—and enter an email address, password, and a few more details.
You'll receive an email from PayPal asking you to activate your account. Then you're ready to shop, send money, and accept payments using PayPal.
To use PayPal, you need to add a payment method to cover your transactions. This can be your bank account, debit or credit card, or a new payment method like MoneyPak™.
Simply link your preferred payment method and you're ready to make purchases or send money.
After completing your sign-up, start enjoying all the benefits of PayPal. Like never having to enter your payment info again. Or paying friends back for dinner using your phone.
Before long, the world's favorite way to pay and get paid will also be yours.
Which Account Type Is Right for Me?
PayPal account types are designed to provide you with the right amount of functionality for your needs. There is no cost to set up an account—no matter which type you choose. You can upgrade your account at any time.Account type comparison chart
How Much Does It Cost to Pay with PayPal?
It's free to sign up for a PayPal account. PayPal does not charge any fees when you pay for goods and services within the US using your account. There are fees in other cases, such as:
- Paying for goods and services outside the US
- Receiving payments for goods and services
- Receiving money from friends and family made using a debit or credit card
- Receiving payments from other countries
- Sending money with a credit card to friends and family
What Happens Once I Sign Up?
You'll receive an email asking you to activate your account. We do this to make sure you are who you say you are by asking you to verify your email address. It only takes a moment to click on the button in the activation email and enter the password you just created.
Why Do I Need a Funding Source?
When you pay for something or send money with PayPal, we cover the transaction using a payment source, such as your bank account or credit card, or after we use your PayPal balance. We never share this information with sellers or merchants. And our Purchase Protection program covers you against unauthorized payments (See Eligibility), wrong items, and orders that never arrive.
How Do I Add a Funding Source?
It's easy to link your PayPal account to a funding source. After signing up with PayPal, add your debit or credit card or bank account information in the Profile section of your PayPal account. Then each time you shop or send money with PayPal, simply select how you'd like to pay—via your bank account or with your credit card.
Can I Use PayPal and Still Collect Credit Card Reward Points?
Absolutely. Just link your credit card to your PayPal account when you sign up or add it later. Then simply select your credit card as your method of payment when you check out using PayPal and you'll rack up the rewards.
Where Can I Use PayPal?
You can use PayPal at thousands of your favorite online stores—just look for PayPal when you check out online. You can find great deals from selected merchants anytime at our PayPal Shopping site. And you can also use PayPal to pay for items on eBay. Visit Our Store Directory.
How Do I Shop with PayPal?
Choose PayPal at the checkout page.
Log in to your PayPal account using your email address and password.
Select your payment method, such as your credit card or bank account.
Confirm the order with one final click and you're done.
How Do I Send Money with PayPal?
All you need to send money is the recipient's email address or mobile number.
The recipient gets an email or text notification. To withdraw the money, they log in to PayPal or sign up in minutes.
Recipients in the US can withdraw the money by spending it online, transferring it to a bank account, requesting a check, or using a PayPal debit card.Learn More about Sending Money with PayPal
How Can I Get Paid for Selling Things on eBay and Classified Websites?
Whether you want to sell something on eBay, classified websites, online forums, or your own website, PayPal can help you get paid.
To get paid for an item you sell on eBay, you'll need to open a PayPal account first, and then list the item you want to sell on eBay. After your item sells and the winner sends money to your PayPal account, PayPal will send you a payment confirmation.
To get paid for an item you sell on a classified website, online forum, or social networking site, you'll need to open a PayPal account first and then list the item you want to sell. After you and the buyer agree on the purchase price, go to the Request Money tab in your PayPal account and type in the buyer's email address to request payment. PayPal will send the buyer an email requesting payment through PayPal. After the buyer pays for the purchase, PayPal will send you a payment confirmation.Learn More about Getting Paid with PayPal
Can I Use PayPal to Accept Payments on My Website?
Yes. PayPal is an easy and secure way to start accepting payments online. It's also a well-known payment method that your shoppers trust. If you already have a website, use our payment buttons to accept debit card, credit card, and bank account paymentsῶsetup only takes a few minutes. You don't need a separate merchant account and gateway. And your customers don't even need a PayPal account to make a payment. It's easy to integrate our payment buttons onto your site and start collecting payments online.Learn More about Accepting Payments with PayPal
Can PayPal Help Me Fundraise?
Yes. PayPal offers a suite of online fundraising tools to help you collect donations from friends, family, co-workers, or anyone in your social network. You can fundraise by accepting credit cards on your website, or using your PayPal account to request money via email or your mobile phone. We can also help you fundraise on Facebook or create a custom website to support your cause.Learn More about Fundraising with PayPal


text:
Ross Has Heavy Hand Online
Published: Thursday, January 24, 2013 at 12:41 a.m.
Last Modified: Thursday, January 24, 2013 at 12:41 a.m.
Re: "Ross: Spending Cuts Needed to Reduce Deficit," Jan. 2. Your article begins with this paraphrase: "Rep. Dennis Ross would have voted against legislation to stop from going over the fiscal cliff even if it meant going over it."
Although I agree with his fiscal-cliff no vote, this time, here is a canard: Because he voted yes on four of six pork-laden appropriation bills in his tenure, Ross is not conservative. Appropriation bills are huge and dwarf all other spending.
However, when I tried to express my views on this and other political matters on his Facebook page, he deleted all my comments and blocked me from posting.
Were this his personal Facebook page or Twitter feed, this would be immoral, but not illegal. However, so long as I don't threaten, harass or use vulgar language, I have a right to post on his public page, distinct from a private or personal page. He's violating free-speech rights and, by extension, First Amendment rights of redress.
Most readers know that, while I have strong opinions, I've never gotten banned from The Ledger's forums, so I'm clearly not a troublemaker.
Furthermore, if it were "just Gordon" complaining, you might give Ross the benefit of the doubt.
However, many people are making complaints that Ross unjustly blocked them from these social networks.
If Ross is not justified in this, then why is he doing it? To silence those who disagree with legislative requests of rich campaign contributors?
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
- Jul 19:
- MOOC mashup: San Jose State University -- Udacity experiment with online-only courses fizzles
- San Jose State suspends online courses
- Jun 13:
- Cassidy: Could professors' resistance derail online-learning movement?
- May 31:
- Higher ed systems in 10 states adopt online courses
- May 30:
- Mountain View's Coursera strikes huge online-education deal with state university systems
- Online college classes, once aimed at advanced students, target the masses
- May 25:
- San Jose State professors fire back at online class offer
- Document: Open letter from San Jose State professors about online course
OAKLAND -- About two weeks into San Jose State's online education experiment at an Oakland charter school, it became clear that something was wrong. Some of the students in the college's for-credit math courses weren't even logging on.
"I get this call from San Jose State: 'Uh, we have a problem,'" recalled Mark Ryan, superintendent of the Oakland Military Institute, a public school set up on a military model.
It turned out some of the low-income teens didn't have computers and high-speed Internet connections at home that the online course required. Many needed personal attention to make it through. The final results aren't in yet, but the experiment exposed some challenges to the promise of a low-cost online education. And it showed there is still a divide between technology-driven educators and the low-income, first-generation college hopefuls they are trying to reach.
To make it work, the institute had to issue laptops to students, set aside class time for them to focus on the online course, and assign teachers to make sure they stayed on task.
"Without having a class period to do it, I wouldn't have done as well," said Ciara Lowry, a junior at the Oakland Military Institute who passed the college statistics course.
In January, San Jose State and the online educational startup Udacity teamed up to test the idea of offering for-credit college courses to anyone with a high-speed Internet connection, including high school students. The San Jose State Plus pilot started small -- three remedial and entry-level math courses, a cap of 100 students per course at $150 each offered for high school, community college and university students.
Gov. Jerry Brown -- who started the Oakland charter school when he was the city's mayor -- said at the project's unveiling in San Jose that online education could open doors for students whose busy lives don't fit into the traditional college structure or who need better preparation for college studies.
A study on the project, due out in the fall, could validate such hopes.
But giving more students access to college classes is not enough, say some who work with poor and first-generation college students. They are more likely to graduate if they have academic support and involvement in campus life, said Sara Melnick, deputy director of the National College Access Network.
Advocates say online education has potential, Melnick said, but "they want to see it before they believe it."
For the Oakland Military Institute, the courses meant a major investment: With more than 700 students in grades 6 through 12, the school had to devote much of its computer lab space, equipment and staffing to online courses for the roughly 45 students taking the Udacity courses. A donation paid for the course fees.
Answering questions and keeping students on task consumed much of his time, said Omar Solache, a computer teacher with two other job titles. A second teacher was assigned to help ease his load.
"They're so used to having teachers right there with them," Solache said.
Despite the bumpy start, students said they found the experience interesting and worthwhile.
Some said they enjoyed watching the bite-size videos, video chatting with online tutors anytime they needed help and moving at their own pace, reviewing material they didn't understand. A tally of the grades and pass rates is not yet available, as final exams ended just last week, but many students already know how they did.
Lowry, a self-admitted procrastinator, said that when a statistics assignment was due at 11:59 p.m., she sometimes would have a pressing question at 11:30. "I'd type, 'Hi, I need help,'" she said. And, sure enough, help would arrive in no time on her computer screen.
She passed the statistics course, earning credit at California State University and at the institute. She usually does poorly in math, she said, but found the right combination of class time, help from classmates, and virtual tutoring.
"It was still difficult, but we had a lot of support," she said. "I didn't have to spend any money on it, and I'll get college credit."
Follow Katy Murphy at Twitter.com/katymurphy.
Digital divide
More Americans than ever have access to the Internet, but the more educated and affluent are more likely to use a high-speed Internet connection at home — which is needed for online courses — than those of less means and education, an August 2011 Pew survey found:
Percent with high-speed Internet:
Adults 18 and older: 62
White: 66
Latino: 51
Black: 49
No high school diploma: 22
High school graduate: 52
College graduate: 85
Household income:
Less than $30,000: 41
$30,000 to $50,000: 66
$75,000 or more: 89
Source: Pew Internet & American Life Project's Digital differences report, www.pewinternet.org


text:
Hey Guys,
I started on a plugin to see whether a file was watched before. One problem I run into now is to retrieve how much of a file has been watched. I've implemented a StartStopListener with the public void donePlaying(DLNAMediaInfo media, DLNAResource resource) method. Now, whenever I do media.getDurationInSeconds() is always returns 0. Basically what I had in mind, was to get the total duration, and than to check were playback was at (don't know how to this either).
I am running the latest build of ps3mediaserver from svn.
Hope you can help.


text:
If you're reading this, chances are you're a fan of either Call of Duty Black Ops 2 or The Walking Dead. One depicts a global struggle over control of an army of unmanned drones; the other, a small group's attempts to find humanity in a world overrun by undead monsters. They've got at least one thing in commong: Michael Rooker.
Rooker plays Merle Dixon in The Walking Dead. Merle hasn't been seen since season one, when Rick handcuffed him as walker bait and he was forced to cut his own hand off. In season three, he's made his triumphant return, and we're eagerly waiting to find out whether he's plotting some sort of epic revenge.
In Black Ops 2, Rooker plays Mike Harper, a character we knew nothing about going into this interview. Thankfully, Rooker was able to shed some light on Harper, as well as some other projects he's got coming up—Activision's The Walking Dead: Survival Instinct shooter, for example, and Marvel's Guardians of the Galaxy.
And of course, we asked the most important question of all: when are we going to see a Black Ops /The Walking Dead crossover? Read on to find out what he said.
Complex: What can you reveal about your character in Black Ops 2?
Rooker: What can I reveal? Is that the question?
Well I know Activision wants to keep a tight lid on things still…
I can give you—the details that i can share are that my body is awesome. I am aspiring to be like my character, Mike Harper, in the game, as we speak. In the gym every day trying to look like Mike Harper. The guy—they did such a unbelievable, fucking amazing job, and I'm like, "Wow! [laughing] This is cool."
So the guy is ripped?
He's totally ripped. Attitude is awesome, I just—very cool, man. I couldn't be more happy with how Mike Harper turned out and just the attitude and the persona, the toughness, the brashness, you know, very cool characterization as well.
So are you playing any other characters?
I'm Mike Harper, U.S. Navy SEAL, baby [laughing].
So you're fighting in the game's present storyline, not the one in the past?
I will be. There's several storylines, as you know, and so I'm probably the up-front storyline, and yeah, that's—I got a lot of action, a lot of lines, and just a very macho, very cool—I actually have a tan, okay? [laughing] Beautiful stuff, beautiful stuff. I couldn't be happier. Absolutely.
You first got involved with Call of Duty with the "Rezurrection" Zombies DLC for Black Ops. How did you get involved with that—was it because of your zombie-filled repertoire?
I do believe it was because I was in The Walking Dead and the folks over at Treyarch and Activision are big fans of The Walking Dead, and I'm like, "Yeah!" I couldn't be happier. It came sort of out of the blue, and I was like, "Yeah!" I jumped all over it. Absolutely. I had also worked with George Romero maybe 15 years ago in a film, you know? So I was like, "Oh my gosh!" Okay. Yeah, I'm down for that let's do it.
You're a fan of zombie stuff in general?
Oh yeah. Oh yeah, man. Big horror movie fan and sci-fi movie—I just, yeah, love all that to death.
Are you a gamer too?
I am such a great gamer that seven-year-olds kick my butt [laughing]. I swear I am the worst gamer. I try, I try, and I try, but for some reason, you know, it, yeah. I got—everybody beats me. Let's just put it that way. My gaming prowess is so good that I tell nobody who I am online [laughing].
You don't brag? Like, "Hey, it's me, Merle."
I brag to no one. No one.
What does Mike Harper bring to Black Ops 2 that would be missing without him?
Oh my god, wow, I'll tell you what. Without Mike Harper, the color would not be there. The humor—because I bring a great dose of humor—and sardonic humor, at that—and just a pretty out-there amount of kick-assness. [laughing] Yeah, my guy's pretty tough, and willing to bend over backwards and kick your ass.
He's the jokester too?
Yeah, absolutely, absolutely. Willing to take a punch, and get up laughing.


text:
Sign Up For Our Newsletter
Enter Our Contest
Join Us
Dress up your pup in these Christmas pajamas with a darling Rudolf face.
Custom made when ordered. Please allow 4-5 weeks for shipment.
Custom sizing also available. Use this link to add custom size.
Enter your zip code or sign in to view shipping information. For more detailed information see our shipping page.


text:
WASHINGTON (November 21, 2012)—U.S. House Speaker John Boehner has received letter of resignation from U.S. Rep. Jesse Jackson, Jr., D-Ill., a spokesman for the speaker said.
Boehner's spokesman Michael Steel said Wednesday the Speaker's office received a letter of resignation from Jackson, but Boehner's office did not immediately comment beyond acknowledging it received the letter.
Jackson was easily re-elected earlier this month to a ninth term despite not having appeared in public since quietly taking medical leave in June for treatment of bipolar disorder.
The House Ethics Committee has been looking into whether Jackson was involved in discussions about raising money for imprisoned ex-Gov. Rod Blagojevich's campaign in exchange for an appointment to President Barack Obama's vacated Senate seat.
There also have been reports of a federal investigation into possible misuse of campaign money.
In the letter Jackson admits to "his share of mistakes" and acknowledges the ongoing federal investigation.
In the letter, Jackson said he is doing his best to address the situation responsibility, cooperating with investigators and "accept responsibility for my mistakes."
He also said his constituents "deserve a full-time legislator in Washington," something that wasn't in his future because of his health issues.


text:
OAKLAND -- Alice Spearman, the incumbent for the District 7 seat on the Oakland school board, has dropped a pre-election legal challenge against her opponent, James Harris. But not necessarily for good. If Harris wins, Spearman is likely to pursue the matter again, her attorney says Harris lives in Oakland, but children in Harris' neighborhood are zoned into public schools in San Leandro and in Oakland. Residents there vote for Oakland City Council District 7 and for San Leandro school board.
That, Spearman had contended, should make him ineligible to run for a seat on the Oakland school board. "If you can't vote for yourself, it's like, please," Spearman said last month. "How are you going to run in a race when you can't vote for yourself?"
Spearman filed a legal challenge, but a hearing scheduled for Wednesday has been dropped from the calendar, court records show. Harris's attorney, Rod Divelbiss, said he contacted Spearman's attorney last week and demand he drop the challenge or face contempt sanctions. Spearman's attorney, Marc Guillory, said the candidate decided to wait until after the election to take the matter to court.
Harris, a former teacher who started his own media business, chalks the issue up to a distraction from the issues facing Oakland schools, and more divisiveness -- one of the reasons he says he's running in the first place.
"Why isn't she saying, 'Here's what we did, and here's what we're going to do?'" he said of Spearman's campaign.
Harris describes himself as someone who is capable of bringing people together and embracing the middle ground. He thinks district schools should do a better job of promoting what they do well, as many charter schools have done. His son and daughter go to Head-Royce, a private school in Oakland.
Harris said he supports the general principles Superintendent Tony Smith is promoting in his strategic plan; its central tenet is to create "community schools" that support the needs of students and their families. But he said, he'd encourage a better flow of information and ideas between the district office, community leaders and parents and teachers who live the reality of the public education system.
"It's that exchange of ideas that I think is lacking," he said.
Spearman also expressed support for the district's community schools approach, though she stressed that the notion of supporting children's social and physical well-being and turning schools into neighborhood hubs is not a new idea. If elected, she said, she will continue to push the district to place more experienced employees at schools and to hire more people who can work directly with students and families, particularly those who have experienced trauma.
When the school board considered the closure of five elementary schools last fall, Spearman was one of two board members to vote against the proposal. She acknowledged that some schools needed to close, but that she couldn't support the closure of Marshall Elementary, her neighborhood school.
Spearman is known to speak her mind; at public meetings, her remarks sometimes take the form of searing retorts and veiled accusations. In 2007, she was escorted from a tense school meeting by security after chest-bumping a man in the audience who had insulted her.
Last month, in a hearing about alleged charter violations by the American Indian Model Schools, Spearman came to the organization's defense. Despite the fact that state auditors in June found evidence that the schools' founder, Ben Chavis, engaged in financial fraud, conflicts of interest and mismanagement of public funds, Spearman suggested that the district's proceedings were an act of retaliation against Chavis, whom she has described as a friend. Then she went a step further.
"People have already been paid off to do what they want to do," she said, without further explanation, prompting an angry rebuke from her colleague, Gary Yee, who said her comments were inappropriate.
Spearman says she wouldn't characterize her remarks to her fellow board members or to the superintendent as insults. She said she plays an important role on the board, by holding the administration accountable. "I bring the voice of my constituents, and I will ask the hard questions," she said.
Harris said Oaklanders need to go beyond the usual rhetoric -- "This is bad, this is a crying shame" -- and direct their concern in a more focused way, for instance by making sure students have access to a modern, digital curriculum and opportunities for union jobs or college after high school.
"That's literally the foundation of a new Oakland," Harris said. "If we can build better schools, companies will come. If we can build better schools, storefronts will open on MacArthur."
Read Katy Murphy's Oakland schools blog at www.IBAbuzz.com/education. Follow her at Twitter.com/katymurphy.
James Harris
Age: 36
Occupation: Creative Director, Morgan Media Group
Elected history: None
Personal: A small-business owner and former high school English teacher running for school board. Born and raised in East Oakland, he lives in Oakland with his wife and two children.
Education: Bachelor's in communications from Santa Clara University.
Website: www.harris
Alice A. Spearman
Age: 60
Occupation: Consultant, Oakland Unified school board member
Elected history: Elected to OUSD board in 2004, re-elected in 2008
Personal: Born and raised in the East Bay, she attended Oakland schools, as have her children and grandchildren. She is a widowed mother of two adult daughters and a grandmother of two Castlemont students and a preschool-age grandson.
Education: Attended San Jose State
Website: none


text:
SAN ANDREAS - The U.S. Fish and Wildlife Service announced Wednesday that it is reopening the public comment period for a proposal to remove the valley elderberry longhorn beetle from the threatened species list.
The beetle and the bushes in which it spends most of its life have long been an inconvenience for those seeking to build structures or operate farms in areas where they live.
Under federal law, the beetle and the bush it needs are protected, and the resulting regulations have caused increased expenses or delays for projects ranging from the Calaveras County Jail now under construction to a road built several years ago at the Port of Stockton.
The proposal to delist the beetle comes after some farmers have planted elderberry bushes in an effort to increase the habitat available for the insect.
Species are delisted when biologists determine they are no longer in danger of going extinct. The bald eagle is the most famous species to have been listed as endangered and later delisted once its population rebounded.
Information on the proposed delisting can be found online at the website for the Sacramento office of the Fish and Wildlife Service: fws.gov/sacramento.
Comments may be submitted online at the federal rule-making portal, regulations.gov, or by postal mail to Public Comments Processing, Division of Policy and Directives Management, U.S. Fish and Wildlife Service, 4401 N. Fairfax Drive, MS 2042-PDM, Arlington, VA 22203.
Comments submitted either online or by postal mail should be marked Attn: FWS-R8-ES-2011-0063.
The agency extended the comment period by 30 days and will accept comments until Feb. 22.
Location, ST | website.com


text:
I still remember Reggie Lewis's annual Thanksgiving turkey giveaway from 20 years ago. I feel like he was the originator and it's been great to see the Celtics continue the tradition. I must give credit where credit is due. Shaq has really been impressive so far in Boston. He left all the extracurricular stuff back in the Summer and has been all about basketball since putting on the Celtics jersey. He's playing very well and has totally bought into the Celtics ubuntu theme.
8 Responses so far.
I love all the stuff Shaq has been doing around the city, he is really making a big contribution on and off the court. I just read this article on Perkins helping out at Children's hospital: http://www.boston.com/sports/other_sports/articles/2010/11/28/aiming_to_comfort_sick_children_bostons_pros_make_the_rounds/ We really have a great team with a big heart!
tb727 says:
Shaq has been terrific- a rebirth on the floor this year. Here's hoping he can stay in shape for the rest of the season and his injuries will be minimal.
Great to see. Should be interesting to see how Doc rotates the minutes when Perk comes back. Injuries of course are the biggest concern for Shaq.
It´s amazing to have Shaq on the team. He´s doing his job in the court, and also he´s been incredibly funny! We have to be grateful for these moments...
Imagine: The Big Cactus against LA in the finals. Gonna happen, baby! All the way...
Matty Baseline says:
I'm loving having Shaq in green! It's pretty incredible to think that we picked up a starting center for the vet minimum.
How cute are these kids! Shaq has always represented the Nba with class and continues to do so in Boston. Great to see him playing with such energy. Actually ALL the veterans on the team are looking better than ever. Much love to Perk! Looking forward to seeing him back on the floor soon. Don't even get me started on Rondo-the guy who knocked the crown off Lebron's head.
hollister, karen millen, soccer shoes, herve leger, lululemon, celine handbags, new balance shoes, ferragamo shoes, vans, nike air max, abercrombie and fitch, hogan, wedding dresses, mcm handbags, ghd, converse shoes, ugg boots, reebok outlet, oakley pas cher, ray ban pas cher, rolex watches, louis vuitton, ugg, soccer jerseys, insanity, louis vuitton, yoga pants, bottega, lancel, ugg boots, mont blanc, marc jacobs, air max, juicy couture outlet, p90x3, birkin bag, hermes, mulberry, north face outlet, supra shoes, jimmy choo, nfl jerseys, valentino, timberland, asics gel, chi flat iron, montre pas cher, ralph lauren, nike free, beats by dre
tiffany and co, longchamp, michael kors, louis vuitton outlet online, kate spade outlet, ray ban, chanel handbags, true religion outlet, polo ralph lauren outlet, nike shoes, oakley sunglasses, coach outlet store, polo ralph lauren, jordan shoes, louis vuitton handbags, louboutin, coach outlet, ray ban sunglasses, tory burch outlet, toms shoes, air max, ray ban sunglasses, coach factory, oakley sunglasses, nike air max, oakley sunglasses, burberry outlet online, true religion, nike free, air max, louis vuitton, coach purses, ralph lauren, prada outlet, coach factory outlet, louboutin, michael kors outlet, burberry, longchamp outlet, oakley sunglasses, true religion jeans, gucci outlet, air jordan, michael kors outlet, oakley sunglasses, louboutin, burberry outlet online, nike air max, nike free, prada handbags


text:
I read the FAQ and knew how to do it with GUI, but I just cant understand how to do it with PMS_CONFIG script on the Windows enviornment. Can some one help me?
Everytime I need to setup again if I reboot my Windows for the GUI version, so I wanted to know the script version.
Where should I place the PMS_CONFIG script if which file?


text:
This is an excerpt from EERE Network News, a weekly electronic newsletter.
July 20, 2011
New Energy Star Initiative Recognizes the Most Energy-Efficient Products
DOE and the U.S. Environmental Protection Agency (EPA) announced on July 14 the first Energy Star products recognized as the most energy-efficient in their categories. The announcement covers four categories—clothes washers, televisions, heating and cooling equipment, and refrigerator-freezers—although the "Most Efficient" lists are currently only available for clothes washers, televisions, central air conditioners, and air-source heat pumps. The new designation of "Most Efficient," representing approximately the top 5% of the models on the market, aims to provide manufacturers with an incentive for greater product energy efficiency while providing consumers new information about the products that comprise the top tier in each category. The pilot program is part of Energy Star's overall commitment to protect people's health and the environment by encouraging energy efficiency.
The "Most Efficient" lists include products by Crosley, Electrolux, Frigidaire, LG, Panasonic, Rheem, and Samsung, as well as Sears' Kenmore brand and Best Buy's Insignia brand. Later this year, the EPA will initiate a process to consider additional product categories for inclusion in 2012. Consumers can find cited products on the Energy Star website and in stores by looking for the "Most Efficient" designation. In addition to meeting established performance requirements, products must also be Energy Star qualified and certified by an EPA-recognized certification body. Energy Star is a joint program of the EPA and DOE. See the DOE press release and the "Most Efficient" products on the Energy Star website.


text:
5 with Appeal for Jan. 4
Published: Friday, January 4, 2013 at 4:30 a.m.
Last Modified: Thursday, January 3, 2013 at 2:48 p.m.
1. Celebrate the 135th birthday of the people's poet, Carl Sandburg, by listening to an exceptional guitar soloist, Marina Alexander, at 3 p.m. Sunday at First Congregational Church at 1735 5th Ave. W., Hendersonville. The performance is the annual Carl Sandburg Solo Guitar recital, sponsored by First Congregational Church and Wofford College, in cooperation with the Carl Sandburg Home National Historic Site. No admission will be charged, but a $10 donation is suggested.
2. The Americana group Grace Adele & The Grand Band will play at 8 tonight at Southern Appalachian Brewery. A master kazoo player and classically trained dancer, Grace Adele blends comedy and percussive tap dance into her show with the all-strings Grand Band (violin, double bass, guitar and mandolin). Southern Appalachian Brewery is at 822 Locust St., off 7th Avenue. Call 684-1235 or visit www.sabrewery.com for more information.
3. Enjoy the fragrance of freshly chipped evergreens and drink a cup of hot cider on Saturday at Henderson County's annual Christmas Tree Recycling Event from 9 a.m. to 2 p.m. at Jackson Park. Volunteers with Environmental and Conservation Organization will provide the refreshments, and if you bring your own boxes or bags, you can take home free mulch. Last year's recycling event kept more than 1,600 Christmas trees out of the landfill.
4. The 7' Eighty 9' Band is set to take the stage at 8 p.m. Saturday at the Party Place and Event Center in Saluda. The band will play tunes from the '70s, '80s and '90s for dancing. Admission is $9. The Party Place and Event Center is just off Interstate 26 at exit 59. For more details, call 828-749-3676 or visit www.partyplaceandeventcenter.com.
5. There's still time to enjoy outdoor ice skating at Greenville Tech's Ice on Main at the Downtown Courtyard by Marriott, 201 S. Main St. in Greenville, S.C. Tickets are $10 for adults and $8 for children, including skate rental. The fun continues on weekends through Jan. 21. For more information, visit www.iceonmain.com.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
1977-10-01 Char-Koosta News
|1 of 15
small (250x250 max)
medium (500x500 max)
large ( > 500x500)
Full Resolution
This page
Loading content ...
Volume 7 Number 11 Moon of the Half Summer - Half Autumn October 1, 1977 Coalition Supports Indian Treaties Reprinted from Yakima Nation Review SEATTLE: Its name is the National Coalition to Support Indian Treaties (NCSIT) and its purpose is to do just that. Formed this July in Seattle, NCSIT came into being as a new counterforce to the significant national political backlash against Indian tribes across the U.S. NCSIT will, in a kind of stellar balance, provide among non-Indians a push-for-push opposition to the nearly two year old Interstate Congress for Equal Rights and Responsibilities (ICERR). NCSIT in October will disclose its coalition members, consisting of numerous pre-existing national organizations, such as the American Civil Liberties Union, National Council of Churches and a bounty of other concerned organizations. The coalition also plans to have Mason personnel in all states where the backlash is mushrooming, where it will " Conduct a program of public education regarding Indian rights." NCSIT is growing from the Pacific Northwest, where there is the highest number of separate special interest backlash organizations of various sorts in one state. The coalition will also support tribes and organizations in their efforts to protect treaty and tribal rights, as well as cooperating with all such groups in the public education efforts. The Seattle area residents who formed NCSIT, moreover, are not newcomers to Indian - non-Indian conflicts. Many are former members of the now-defunct Citi- zens for Indian Rights (CFIR), a non-Indian support group in the Puget Sound area, which from 1970 till 1974 was active in the area of public education in western Washington while the federal court suit, U.S. vs Washington, was heading toward its conclusion. Dr. Richard Briggs of Seattle, a practicing physician, formed CFIR, and now he's in the forfront as executive director of NCSIT. The National Congress of American Indians, National Tribal Chairmen's Assoc., and the informal National Indian Alliance have all welcomed NCSIT's birth. The faces of NCSIT people will doubtless become quite familiar around Indian Country, and their names will be remembered more fondly than those of the principals of ICERR. NEW CONGRESSIONAL BILL TERMINATES TRIBES Reprinted from Yakima Nation Review The " Native Americans Equal Opportunity Act", introduced in the U.S. House of Representatives Sept. 12, by Rep. John Cunningham, D-Wash., provides for the abrogation of all treaties between Indian tribes and the U.S. government and the abolition of the Bureau of Indian Affairs. Cunningham, 47, is the junior congressman from his home state of Washington. He was elected this past May 17, to replace Brock Adams, whom President Jimmy Carter had named Secretary of Transportation in the Carter administration. The Cunningham treaty abrogation act requires the President to establish procedures for the liquidation of the trust responsibility and dismantling of the BIA, and requires the President to publish a " proclamation" when all tribal termination is completed. Targets for termination, in the Cunningham bill, are all current federally recognized tribes, all currently terminated tribes, and tribes whose reservations were established by means other than treaties. The bill provides for transfer of all holdings of tribal land assests to tribes themselves directly for allotment to adult members and liquidation of common trust title. Included as targets in this bill are " any Indian tribe, band, nation or other organized group or community, including any Alaska Native Village or regional or village corporation All hunting and fishing rights of the tribes will also be dissolved, with Indians becoming subject to all federal, state and local laws governing hunting and fishing, as well as all other jurisdictional areas in common with non-Indian citizens. Stimulus for the Cunningham bill was the so-called "Fish War" in his home 7th District, an urban and suburban area in the south section of Seattle, Wash., including Auburn, Kent, Renton, South Bellevue, Mercer Island and south Seattle, where many non-Indian fishermen have raised Indian fishing rights guarantees to a number one controversy. Cunningham in announcing introduction of the bill, Sept. 12, in Washington D.C., said he was " achieving two goals that I talked about during my campaign ". He said those two goals were to " resolve the controversy surrounding the Boldt decision " regarding fishing on Feb. 12, 1974, " by providing to all citizens an equal opportunity to fish and hunt without discrimination of ethnic background. His second goal, he said, was " to end the paternal and protective role currently being played by the Bureau of Indian Affairs " which holds Indian back from (continued on p. 2)
Object Description
|1977-10-01 Char-Koosta News
|Confederated Salish and Kootenai Tribes of the Flathead Reservation.
|Salish Indians --Newspapers.; Kutenai Indians --Newspapers.; Pablo (Montana) --Newspapers.; Kootenai Indians
|Coalition Supports Indian Treaties; New Congressional Bill Terminates Tribes; Grateful to the Tribal Council; Forest J. Gerard Confirmed; Energy Resource Development; National Indian Rodeo Set for Tulsa; Indian Crafts Fair in Tulsa; Flathead Community College Starts Classes; Social Security and You;
|Confederated Salish and Kootenai Tribes of the Flathead Indian Nation
|Date Original
|Date Digital
|Resource Identifier
|Rights Management
|Copyright (c) Salish and Kootenai Federated Tribes, all rights reserved.
|Contributing Institution
|Salish Kootenai College
|D'Arcy McNickle Library
|Vol. 7; No. 11
|Digitization Specifications
|Digitized at the University of Montana Maureen and Mike Mansfield Library; Scanned as master TIFF using Bookeye 3 scanner at 400 ppi, 8 bit grayscale; Optical Character Recognition with Abbyy FineReader Corporate Edition; Derivatives created using Photoshop CS
Add tags for 1977-10-01 Char-Koosta News
Post a Comment for 1977-10-01 Char-Koosta News


text:
Friday, Sept. 28, 2012
AUGUSTA, Ga. -- The Drug Enforcement Administration will be hosting another National Prescription Drug Take-Back Day on Saturday.
The event will take place at multiple locations in the greater Augusta area from 10 a.m. to 2 p.m.
Here are the locations in the area:
North Augusta Public Safety
Parks Pharmacy
437 Georgia Avenue
North Augusta, SC 29841
Directorate of Emergency Services
Dwight D. Eisenhower Army Medical Center Lobby
300 East Hospital Road
Fort Gordon
Augusta, GA 30905
Richmond County Board of Education Police
864 Broad Street
1st Floor
Augusta, GA 30901
McCormick Police Department
Food Lion
South Mine Street
McCormick, SC 29835
Barnwell County Sheriff's Office
599 Joey Zorn Boulevard.
Barnwell, SC 29812
Newberry County Sheriff's Office
520 Wilson Road
Newberry, SC 29108
If you have questions or want more information, call 1-800-882-9539.


text:
The California Supreme Court is located in the Earl Warren Building at Civic Center Plaza in San Francisco. Fax filings are not permitted unless approved by the court in advance. For the Supreme Court's case management system, please visit the Case Information page.
|Mailing Address
|Earl Warren Building at Civic Center Plaza
|Supreme Court of California
350 McAllister Street
San Francisco, CA 94102-4797
|(415) 865-7000
|Supreme Court Hours
|Monday - Friday 9 a.m. to 5 p.m. (except court holidays)
|Supreme Court Clerk/Administrator
|Frank A. McGuire
Los Angeles
The California Supreme Court hears oral argument in Los Angeles four times each year. Customarily, the Los Angeles court sessions are held in April, June, October and December.
|Ronald Reagan State Office Building
300 South Spring Street, 3rd Floor
Los Angeles, CA 90013
The California Supreme Court normally hears oral argument in February and November at the Stanley Mosk Library and Courts Building in Sacramento.
|Stanley Mosk Library and Courts Building
914 Capitol Mall
Sacramento, CA 95814
Supreme Court of California
Earl Warren Building at Civic Center Plaza
350 McAllister Street
San Francisco, CA 94012-4797
Holiday schedule
The California courts will be closed in observance of the following holidays:
|New Year's Day
|Friday, Jan 1
|Martin Luther King, Jr. Day
|Monday, Jan 18
|Lincoln's Birthday
|Friday, Feb 12
|President's Day
|Monday, Feb 15
|César Chávez Day
|Thursday, Mar 31
|Memorial Day
|Monday, May 30
|Independence Day
|Monday, Jul 4
|Labor Day
|Monday, Sept 5
|Columbus Day
|Monday, Oct 10
|Veterans Day
|Friday, Nov 11
|Thanksgiving Day
|Thursday, Nov 24
|Day after Thanksgiving
|Friday, Nov 25
|Christmas Day
|Monday, Dec 26