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Definition of unsustainable in English:
1Not able to be maintained at the current rate or level: macroeconomic instability led to an unsustainable boom
More example sentences
- "Many sectors need investment, but the current growth rate is unsustainable.
- Given Wednesday's government figures showing an increase in house repossessions, the signs suggest that current price levels are unsustainable, experts warned.
- Now he is urging further government intervention to push housing prices to still more absurdly unsustainable levels.
1.1 Ecology Upsetting the ecological balance by depleting natural resources: unsustainable fishing practices
More example sentences
- Scientists attribute the declines to pollution, habitat degradation, and unsustainable fishing practices that allow species to be harvested faster than they can reproduce.
- At the same time, the country's fragile economy, based on unsustainable exploitation of natural resources, has imploded.
- It pledges to end unsustainable fishing by 2015, where possible.
1.2Not able to be upheld or defended: the old idea was unsustainable
More example sentences
- No one likes admitting that they were wrong, least of all military personnel, but there comes a point when retreat can be more honourable than defending an unsustainable position.
- In that respect we find that the Adjudicator's determination is unsustainable and cannot be upheld.
- Black Wednesday followed two months later, when the tension between the need for lower interest rates to stimulate demand and for higher interest rates to defend the pound became unsustainable.
- Example sentences
- As the supply of lumber-grade BC trees dwindles due to unsustainably high levels of harvesting by forest companies, residents of BC lumber towns hoped that free-market dynamics would slow the rate of cutting but keep the prices climbing.
- America's trade deficit has passed the 5% of GDP that most economists feel is unsustainably high, and is headed to 6%, in part because the import bill has been swollen by high oil prices.
- This dependence produced parasitic governments which irresponsibly and unsustainably sold the vast national resources to the highest international bidder while heavily relying on those gains to run the country.
For editors and proofreaders
Syllabification: un·sus·tain·a·ble
Definition of unsustainable in:
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Winter Hairstyles to Try Now
As the weather gets colder, your skin—which may have been super oily in the summer—can now transform into a dry, flaky mess. Make sure to combat that with a good exfoliator. Burt's Bees Citrus Facial Scrub is fantastic because it gently exfoliates but leaves your skin moisturized as well. Also, the citrus scent is perfect for waking you up on those days when you'd rather stay in bed than go to class. $8, Burtsbees.com
Physical fitness class was my least favorite class on earth. First of all, I'm not really a sports fan, and when I was in college, the only physical activity I liked to do was apply my beauty products. This is one of my faves because it lasts through any workout and contains "motionsense" technology, which releases a "burst of freshness with every move you make." $4.69, Drugstore.com
Pointy-Toe Pumps: The Perfect Fall Shoe

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Pack one of these brownies in a lunch box as a special treat.
Prepare brownies as directed, but do not cut brownies. Microwave 1/3 cup whipping cream in medium microwaveable bowl on HIGH 45 sec. or just until cream comes to boil. Add 6 oz. BAKER'S White Chocolate, chopped. Stir until white chocolate is completely melted and mixture is well blended. Drizzle over brownie. Let stand until set before cutting to serve.
Prepare as directed, using one of the following options: Super Chunk Brownies: Stir 2 pkg. (4 oz. each) BAKER'S Semi-Sweet Chocolate, coarsely chopped, and 1/2 cup raisins into prepared batter before pouring into prepared pan and baking as directed. Cake-Like Brownies: Stir in 1/2 cup milk along with the eggs and vanilla, and increase the flour to 1-1/2 cups. Extra-Thick Brownies: Spread prepared batter into 9-inch square pan. Bake 50 min. Cool, then cut to serve. Makes 16 servings. Extra-Fudgy Brownies: Use 4 eggs.
* Nutrition information is estimated based on the ingredients and cooking instructions as described in each recipe and is intended to be used for informational purposes only. Please note that nutrition details may vary based on methods of preparation, origin and freshness of ingredients used.
K:2657 v0:54515


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Export Requirements for Iraq
IQ-16 (May 23, 2016)
Asterisks (*) indicate the most recent revision to these requirements. To search, click on your browser's "Edit" menu, then click on "Find (on this page)". Enter "*" in the "Find What" field, then click "Find" or "Find Next" until all asterisks have been identified.
Eligible/Ineligible Products
- Eligible
- Red meat and red meat products.
- Poultry and poultry products.
Note: It is recommended that exporters secure an import permit in advance of shipping.
- Ineligible
- Poultry and poultry products derived from birds originating from the State of Missouri.*
Note: Please be advised that OFAC no longer administers sanctions against the nation of Iraq; however, OFAC administers sanctions against certain individuals and entities pursuant to the Iraq Stabilization and Insurgency Sanctions Regulations, 31 C.F.R. part 576. A list of all Specially Designated Nationals and Blocked Persons, including those whose property and interests in property are blocked pursuant to the ISISR, may be found on the OFAC website. Consult the U.S. Treasury Department Web site http://www.treas.gov/offices/enforcement/ofac/ for further details.
Documentation Requirements
- Certification Requirements
- Obtain FSIS Form 9060-5.


text:
- Jul 9:
- Mercury News editorial: Bay Bridge still lacks review by independent experts
- Bay Bridge's steel bolt failures reveal inadequate metallurgy expertise, experts say
- Roadshow: Bay Bridge delay gets mixed reviews
- Jul 8:
- Bay Bridge: Opening of new span to be delayed for weeks or months
- Jul 4:
- Bay Bridge: Bolt test results looking good, but final numbers still coming in
- Jun 12:
- Bay Bridge: Open new span with or without bolt repairs, experts say
- May 31:
- Daniel Borenstein: Bay Bridge officials don't walk the transparency talk
- May 24:
- Bay Bridge bolt maker says report 'exonerates' it from blame
- May 22:
- Details emerge on who picked steel for Bay Bridge that later broke
- May 21:
- Dan Walters: Is Bay Bridge debacle a harbinger?
- Gov. Jerry Brown: Bay Bridge 'not going to open unless it's ready'
- May 7:
- California Gov. Jerry Brown breaks silence on cracked Bay Bridge bolts
WEST SACRAMENTO -- Just three months ago, Gov. Jerry Brown stood on the Bay Bridge and pushed a glowing button that started a countdown for the Labor Day opening of the gleaming new eastern span.
"We're going to have a bicycle race, running, walking -- tens of thousands, maybe hundreds of thousands of people," Brown said. "This has taken a lot of blood, sweat and tears, a lot of billions of dollars, but ... it's worth it because we're building for the future."
On Tuesday, however, Brown had a saltier way of describing the $6.4 billion bridge project after three dozen hefty high-strength steel bolts snapped like pretzels in early March and left everyone asking about the bridge's seismic safety.
"Don't know if it's a setback," the governor said. "I mean, look, s--- happens."
After seven weeks of scrambling to respond to the crisis, Caltrans is finally ready to go public with how it will fix the embarrassing problem.
On Wednesday morning, Caltrans and the California Transportation Commission will brief the Bay Area Toll Authority, co-managers of the replacement span. Along with getting cost estimates for the Big Fix, the authority will learn whether Caltrans will open the new bridge as scheduled on Sept. 3.
Caltrans and the bridge contractor, American Bridge-Fluor Joint Venture, may also release their internal probe into why the hefty anchor rods -- 3 inches in diameter and 17- to 24-feet long -- broke in the first place.
Caltrans' troubles started in early March just days after contractors tightened down 96 anchor rods on the pier east of the main span tower that tie the bridge deck and the columns to shear keys, which would help control swaying during an earthquake. A third of the bolts broke.
Engineers immediately blamed a well-known phenomenon that affects high-strength steel under heavy loads. It's caused by hydrogen atoms squeezing into the spaces between steel's crystalline molecules, thus weakening its strength.
But Caltrans hasn't yet said whether hydrogen embrittlement occurred during fabrication in Ohio or while the rods sat in their casings in water for five years on the bridge before contractors tightened them down.
Either way, engineers can't just replace the defective bolts. That's because the shear keys are sandwiched between the bridge deck and the tops of the reinforced concrete columns that support the bridge. The bolts are inaccessible from the bottom, and there is only 5 feet of room on the top.
Caltrans is expected to propose placing an exterior steel sheath or "saddle" around the shear keys that would take the loads the rods were supposed to bear. In anticipation of the fix, American Bridge-Fluor has already ordered the steel from a Mare Island fabricator.
Speaking to reporters Tuesday after attending a memorial service at the California Highway Patrol Academy, Brown said it was premature to "pull our hair out yet" and that he was "optimistic until proven otherwise" that the new addition to the nation's busiest bridge will work out.
"There are very professional engineers that are looking at this thing, and when they're ready to give us their report I think the public will be satisfied," he said.
Since the cracked bolts were discovered, Brown had refrained from commenting on a project that he had embraced as far back as when he was running for Oakland mayor in 1998 and had pushed for a spectacular design that could serve as a "civic symbol" for Oakland, a triumph of design and function.
At the time, Gov. Pete Wilson sought a more utilitarian replacement span, which was panned by Elihu Harris, Oakland's outgoing mayor, as "a freeway on stilts." Harris, Brown and other leaders saw the new Bay Bridge as a gateway, a chance to show off Oakland's port and hills.
Much of Brown's legacy as governor is tied to his aggressive pursuit of major infrastructure projects: high-speed rail, twin water tunnels in the Central Valley and a new Bay Bridge.
"People come and go, but the bridges and roads and the tracks, they stay for a long time," Brown said at the countdown event in February.
Still, some political analysts say a setback on the Bay Bridge wouldn't necessarily hurt Brown's big-project image.
"It would be better for the governor if things go smoothly, but he doesn't own the Bay Bridge like he owns high-speed rail and the peripheral tunnels," said Ethan Rarick, director of the Matsui Center at the Institute of Governmental Studies at UC Berkeley. "This is less his baby."
Contact Steven Harmon at firstname.lastname@example.com or 916-441-2101. Follow him at Twitter.com/ssharmon. Read the Political Blotter at IBAbuzz.com/politics.


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Ten years ago, Portland-based musician Tim Snider set out on his first tour, opening for Texas-born, London-based singer and songwriter Rodney Branigan.
Now, on the 10-year anniversary of the collaboration, the pair is touring again and will co-headline a show at 8 p.m. Thursday, Nov. 14, at The Playwright, 258 A St., Ashland. The cover is $10.
Snider plays and loops the electric violin, guitar, percussion and vocals to create a style that has been dubbed a "world-folk-jazz hybrid." He's typically a one-man band, but on his new, rhythm-driven original album, "Let Go, Jump in the River," released last May, he is accompanied by a handful of musical friends.
Branigan has mastered guitar, mandolin, piano and percussion and can play two and, sometimes even three, instruments simultaneously. (Check out his YouTube videos if you don't believe it.)
See www.brokenguitars.com or www.timsnidermusic.com.
Location, ST | website.com


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The Women in Jazz archive is moving
The Women in Jazz archive is moving to new digs!
This is the new site. It looks a lot like the old one, but it will be much more functional and up to date.
Keep checking back as we work on the upgrades.
The new site will be up by the middle of September.
See you again!


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Saturday, October 12, 2013
Patek Philippe: The Watch to Watch For
Posted by Shreve & Co. at 3:04:53 AM in Patek Philippe (29)
Swiss luxury watch manufacturer Patek Philippe was founded more than one and a half centuries ago in Geneva and Vallée de Joux, the region known as home of the biggest names and finest pieces in the watchmaking industry. Since 1851, Patek Philippe has been manufacturing haute horlogerie pieces and top-of class movements, including the most complicated mechanical watches in the world. It is easily recognized by watch experts and aficionados as the most prestigious watch brand, period. Whatever acclaim the company name now enjoys is the fruit of decades upon decades of unsurpassed watchmaking standards and pioneering spirit. Patek Philippe pioneered the chronograph, the split-second hand, minute repeater, and perpetual calendar. Its penchant for making things extraordinary and literally 'complicated' established its reputation among its varied clientele, from royalties and dignitaries, to young professionals making smart investments and fathers looking for meaningful legacies to pass on to the next generation.
Check out Patek Philippe's most recent strokes of genius at authorized Patek Philippe retailers such as Shreve & Co. in Palo Alto.
Written by Shreve & Co. at 3:04:53 AM in Patek Philippe (29) | Comments (0)
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|Highs & Lows
|In the News
|Insulin & Pumps
|Men's Issues
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|Women's Issues
|Oral Meds
Food is My Demon
Categories: Emotions Food Highs & Lows Insulin & Pumps Real Life Relationships Type 1 Type 2 Oral Meds
Tags: food addiction
Views: 3889
I've been in a mood all day and I think part of the reason is because I've been thinking about writing this post. This is not an easy subject to talk about and I realize that there are people who will vehemently disagree with me and others who will completely identify with what I'm about to say.
I've been thinking about writing a post like this for some time, but I don't think I had the nerve to put this out there for the whole internet world to read. But after a fairly intense discussion with sara n. dipity last week about food, food choices and, essentially, will power, I think it's time for me to go ahead and put it out there.
The name of the first blog I ever authored was Confessions of a Food Addict. That wasn't just a funny sounding name; I believed then and continue to believe now that I am addicted to food. And I believe I have been for a long time... even when I was a kid.
I grew up in a healthy household. Dad cooked dinner every night, we rarely ate out, no cereal with sugar as the first, second or third ingredient, no junk, no chips, none of that. But I managed to find it anyway. I remember walking to and from school and frequently stopping at the corner drug store for candy. In fact, I remember running the 50-yard dash in elementary school with my hand over the pocket of my skirt so that the bags of M&Ms and Skittles I had poured in there wouldn't fall out.
Despite being fairly athletic as a kid -- lots of little league, bike riding and extra curricular sports in high school, etc., etc.-- I was always heavy. I loved to eat. I still love to eat.
I think I found a little peace when people (like Oprah) started acknowledging that food addiction is real. Unlike other addictions, it's difficult to get away from a food addiction because the thing I am addicted to is actually required for life.
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Megan was diagnosed in 2009 with Type I. As an RN, she was familiar with the medical side of her diagnosis; learning to be a good patient on the other hand, was and continues to be the challenge of her day to day life. (Read More)
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text: Donald Sutherland is quickly becoming the face of the fourth installment of the "Hunger Games" franchise. Portraying President Snow, Sutherland delivers a speech about unity to the people of the fictitious Panem in the second official trailer for "The Hunger Games: Mockingjay -- Part 1." In the trailer, Sutherland is flanked by Josh Hutcherson's Peeta Mellark and Jena Malone's Johanna Mason. The movie is due for release Nov. 21.


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A humble humanitarian
Antopol quietly protects hospital's patients, staff
|Dr. Stephen Antopol is Waterbury Hospital's Humanitarian of the Year for his work with safety and preparedness at the hospital. Darlene Douty / publican-American
To him, the word "humanitarian" conjured Herculean efforts to alleviate suffering on the front lines of life's most dogged problems, like famine or poverty, in far-flung places.
In his own humble way, however, Antopol has devoted a career — and subsequent retirement that has been anything but retiring — ensuring the well-being of others. His efforts earned him the admiration of colleagues, who recently nominated the pathologist as Waterbury Hospital's Humanitarian of the Year. Antopol will be celebrated at the hospital's charity gala next Sunday at La Bella Vista at the Pontelandolfo Community Club in Waterbury.
Though he does not dispense medicine under an Equatorial sun, Antopol looks out for others in small but significant ways. He spent a quarter century working at Waterbury Hospital before retiring five years ago. Most days he still walks the hospital halls, now ferreting out any violations of regulations, industry codes, or common sense that could impact the heath, safety and well-being of the hospital's staff, patients and community. As administrative chairman of the hospital's Infection Prevention Committee, that has meant rising in pre-dawn hours to commute from Woodbridge to arrive in Waterbury by 3:30 a.m. so that he can inspect areas of ongoing construction before construction workers show up. If he finds a problem, he shuts work down until it is corrected. To the uninitiated, such tasks might seem mundane, yet there is much to consider. For instance, regulations require air disturbed at a construction or renovation site be filtered so potential hazards don't infiltrate areas where sensitive patients might be.
In Antopol's basement office, a 115-pound dummy rests in a chair, waiting to be carried in mock evacuations that will be orchestrated in coming weeks. He checks and rechecks with staff to make sure the facility has 96 hours "worth of everything" to keep the business of caring for people running smoothly amid any tumult, such as Hurricane Sandy.
"We have to keep our patients safe and, if possible, continue to run a hospital" no matter what calamity, said Antopol. Whether it's germs or nature, he said, "The steps are similar. The specifics are different. You're making the best plan you can."
Between rounds of construction sites and the hospital's units, Antopol trolls the Web, searching English-language health sites from around the globe to monitor outbreaks of everything from standard to Avian flu. Though Antopol admits to being something of a "worry wart," threats of spreading disease or bioterror aren't enough to keep him up.
"What keeps me up is if I think I didn't do something just right the day before," he said.
Rachel Crosby, the hospital's infection prevention specialist, said although his work may be behind the scenes, Antopol's efforts yield a direct and important impact. Crosby was among those who nominated Antopol.
"Everyone knows of his tireless dedication and commitment. He really does go above and beyond to ensure the safety of staff, patients and visitors," she said. "He's an extra set of eyes and ears in our hospital ... The staff appreciate him coming around to every floor, every day. They say they look forward to it."
Along those rounds if Antopol spies something amiss, whether an inappropriately adorned person entering a vulnerable patient's "isolation" room or a cart blocking a fire door, he fixes it, or sets in motion steps to make sure issues are resolved. Crosby said Antopol's humor and humility almost always prompt compliance.
As a pathologist, Antopol fashioned himself a somewhat unique practitioner. He filled many similar safety and infection preparedness posts then, but also oversaw the pathology department and reviewed samples from patients. Many pathologists might be considered the invisible link in the patient diagnosis process. They toil in labs, examining samples of tissue rather than the people to whom they belong. But Antopol saw many patients over his years in pathology.
"If I knew I was going to get the specimen and needed information, I would go up and speak to patients, which is an odd thing for a pathologist to do. But it's useful, rather than trying to just use the chart," said the married father of two grown daughters. "I'm taking responsibility for the diagnosis, so I may as well get all the information I need."
Even as the "humanitarian" accolade comes in retirement and is spurred by his infection control and bioterror preparedness work for the hospital, trying to keep people safe has been a career-long constant.
"Microbiology and epidemiology go together: It's, 'How does a disease get spread?'" said Antopol, who earned degrees in microbiology before attending New York University's medical school and serving in the Army as a first lieutenant, where he was a safety officer for a microbiology lab.
His interest in infection control further heightened before Antopol moved to Connecticut from New York in the early 1980s. He and other specialists puzzled over a new disease, later identified as AIDS.
"I was trying to find out what was going on and try to keep people safe from it," Antopol said.
Though years have passed, an understanding of AIDS has evolved and Antopol has since retired, he's still essentially aiming for that same goal: to keep people protected through what he calls a "culture of safety" across the hospital, from surgeons to housekeeping staff.
As for the demanding schedule of his retirement, the 70-year-old said: "I'd go nuts if I didn't have anything useful to do."
If You Go
Waterbury Hospital's annual Charity Gala takes place next Sunday starting at 5:30 p.m. at La Bella Vista at the Pontelandolfo Community Club in Waterbury. For information, call 203-573-6000.
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- Home dialysis giving patients their lives back
- Fake medicine a threat to consumers
- A humble humanitarian
- Woman with early Alzheimer's speaks out on illness
- Detergent packets pose health hazard
- Heart disease a woman's disease, too
- Ratchet up the difficulty of your pushups
- Soup offers a fresh take on squash at Thanksgiving
- A colorful, seasonal quiche for Thanksgiving
- A light, fresh take on the fresh Thanksgiving veggie


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Dan Decker, of Aurora, has been named the new superintendent of schools for the Neosho R-5 School District.
Decker, who is currently in his fourth year as superintendent at the Aurora R-8 School District, was selected by the board of education in a 6-0 vote during a closed session meeting on Monday, Dec. 3.
He will begin his duties with the district on July 1, 2013.
"We have spoken with his colleagues, co-workers, subordinates and patrons and the first thing that is readily apparent about Dan in their opinions is that he is a man of integrity," the school board said in a statement.
Stay tuned to www.neoshodailynews.com, for more on this story.
Location, ST | website.com


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The Next Generation of Supercars Is About to Land
February 20th, 2013
Boy oh boy, the rich are about to have an ample playground of new supercars to enjoy.
Pure performance, ultimate luxury, scarce prestige and sheer sexiness all lie ahead for the garages of the wealthy. Ferrari, Bentley, Rolls-Royce, Aston Martin, Spyker and Porsche all are readying new offerings designed to capture the hearts of enthusiasts and the dollars of the one percent.
This newest class of automobile extravagance will likely debut to the world in Geneva next month, but information is slowly leaking across the interwebs at this very moment. Here's what we know so far.
Car Industry News, Car Minded, Exotic Cars, Foreign Cars, General Chat


text:
Mizzou Football's Justin Britt and E.J. Gaines have accepted invitations to play in the 89th East-West Shrine Game, scheduled for Saturday, Jan. 18
Click here for the original story.
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MyChart Login
Home > Health & Wellness > Health Library > Medical History for Allergies to Insect Stings
Your doctor will ask you several questions to find out
whether you could be having an
allergic reaction to an insect sting. Questions may
include the following:
You may be asked to capture or kill the insect and bring it in for
You may be asked about previous stings and what reactions (if any)
you may have had. Your doctor will also try to determine whether you have any
medical conditions that might affect your risk of future allergic reactions or
your choice of treatments for the allergy.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineSpecialist Medical ReviewerRohit K Katial, MD - Allergy and Immunology
Current as ofFebruary 20, 2015
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Apple Selloff Prompts Debate Over Tax Impact Versus Fundamentals
By Drew FitzGerald and Murray Coleman
Applees returned to their downward December trajectory Monday, rekindling the debate over whether the stock's sharp selloff owes to end-of-year profit-taking or more serious concerns about its long-term profitability.
The answer is key to determining whether the world's most valuable publicly traded company can recover much of the $167 billion in market value that it has lost in less than three months.
Monday, Apple shares recently slid $4.46 to $528.79, leaving it down about 9% this month. The stock is on track to post its weakest December in more than a decade; the last time shares plummeted so far in December came in 2000, when they traded around a relatively paltry $8.
Some analysts point to the fact that Apple, which has surged 66% over the past two years, makes an attractive sale for fund managers looking to lock in solid gains in a year in which strong technology performers have been rare. Taxes on capital gains and dividends also are expected to increase regardless of the outcome of budget negotiations in Washington, adding to the end-of-year pressure.
"There could be some more downside in the short term with tax issues and fiscal-cliff policies still unclear," said Rodney Che, a portfolio manager at United Asset Strategies. The advisory shop in Garden City, N.Y., manages about $600 million in assets for high net worth and institutional investors.
Others point to problems specific to Apple. Jefferies on Monday cut its price target on the stock to $800 from $900, warning that slowing sales growth would pressure the long-term profitability of its most successful devices. Jefferies, though, still calls the company a buy.
Nomura Securities analyst Stuart Jeffrey likewise warned the company's relatively conservative margin guidance has given investors reason to wonder whether the climbing margins seen during the past two years are in danger of stalling as markets for iPhones mature and sales of the iPad Mini grow at the expense of their larger precursors.
"It may be that we've got six months where we don't know where gross margins end up," he said, adding investors tend to react more harshly to negatives during periods of uncertainty.
Nomura has a neutral rating on the stock, while Jefferies still calls the company a buy.
Topeka Capital Markets, another stock-analysis firm, released final monthly sales data that showed the company benefiting from above-average sales last month, suggesting the stock's latest selloff owes more to "irrational pessimism" than to fundamental weakness.
"Everyone's searching for something," said Topeka analyst Brian White, who also has a buy rating on the stock. He has argued that selling ahead of higher taxes next year remains "at the crux of the decline, which drives investor fears that the 'other guy' knows more than they do, further exacerbating the selling pressure."
Many shareholders also pay close attention to technical cues created by other investors. The stock last week created a so-called death cross when its 50-day moving average price slid below the 200-day average, a negative sign for traders who use stock trends to infer its future performance.
Many "fast money" managers hold positions in Apple, according to Sam Katzman, chief investment officer at Constellation Wealth Advisors, which manages about $5 billion in assets.
"If you look at the top holdings by leading hedge funds, Apple is at the top or near the top of most lists," he said. "As 2012 closes, it's not surprising to see a lot of the fast money crowd getting out to lock in gains."
Early news around the iPhone 5 and newest iPads could do as much to hurt Apple's stock as help it, if past product launches are any indication. Apple shares tend to weaken after major product launches. The company's newest gadgets are no exception.
Apple hit an all-time intraday high of $705.07 in September ahead of the iPhone 5′s initial release, prompting concerns that the stock was getting overheated. Such concerns were "exacerbated by the reality of paying higher capital gains taxes," said Sam Turner, director of large-cap portfolio management at RiverFront Investment Group.
Investors who sold for tax-related reasons could be back in the stock by early next year, Mr. Turner said. "This is a good time in our view to use dips to buy Apple," he said. "But over the next one to two months, it could be rather range-bound."
For now, investors may do best to view the stock in the long term, advisers said.
"In our view, this is one stock you want to remain patient with since the larger smartphone penetration story is still playing out," Mr. Turner said. "Apple and Samsung remain the dominant leaders in that space, and we don't think that's likely to change in the near-term."


text:
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text:
The 14U Texas Bandits are currently holding tryouts for the upcoming 2012-2013 season for bracket pitchers and catchers. We offer private facilities located in the Cypress/Tomball area, which include new, premier-level indoor and outdoor facilities. The Texas Bandits are looking for dedicated players that are committed to excellence in all aspects of the game. The goals of the 14U Texas Bandits are to prepare the girls for high school ball and further develop each player to reach her maximum potential.
Both gym shoes and cleats will be needed for tryouts as players will be on turf as well as grass.
Tryout dates:
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Saturday, 8/11.
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text:
Definición de seminal en inglés:
1Strongly influencing later developments: his seminal work on chaos theory
Más ejemplos en oraciones
- The artist has had a seminal influence on the development of modern Irish music, since he first hit the scene in Dublin in the 1960s.
- In 1870 he produced a seminal volume that would influence generations of garden-makers throughout the world.
- The rugged brick and timber house he designed for his family on a sloping bush site in Chatswood in 1963 was a seminal work that greatly influenced the development of the Sydney School.
influential, formative, groundbreaking, pioneering, original, creative, innovative;
imaginative, productive, major, important
2Relating to or denoting semen: the spermatozoa are washed to separate them from the seminal plasma
Más ejemplos en oraciones
- The seminal plasma of mammals is a complex fluid, which serves as a carrier for the spermatozoa in their journey from the male testes to their target, the female uterus.
- The seminal plasma of mammals contains a group of acidic proteins that bind to the spermatozoa.
- At the same time the seminal vesicles and prostate gland contract and release seminal fluid into the urethra.
spermatic, sperm, seed
technical spermatozoal, spermatozoan
2.1 Botany Relating to or derived from the seed of a plant: the seminal root system
Más ejemplos en oraciones
- Upon the death of the seminal root the plant fragments into several independent stolon systems and begins the clonal stage of its life cycle.
- In the uniform exodermis of seminal roots of Zea mays, intact plasmodesmata were found even in exodermal cells where the walls were suberized.
- Seminal roots do not form a coleorhiza since the scutellar node tissue is already differentiated when seminal roots emerge and can easily be penetrated.
seminally adverbio
- Oraciones de ejemplo
- That would place a wholly new perspective on Indian policies in South Asia, no less than the doctrine threatening to seminally reshape U.S. foreign policy.
- This was spurred on by many magazine articles of the time, most seminally a December 1959 True magazine article describing the discovery of large, mysterious footprints the year before in Bluff Creek, California.
- A person, it appeared, could pick and choose between several possible explanations; St. Augustine shouted of the 'The Fall' and our need for punishment for being seminally present in Adam.
For editors and proofreaders
Saltos de línea: sem|inal
Definición de seminal en:
¿Qué te llama la atención de esta palabra o frase?
Los comentarios que no respeten nuestras Normas comunitarias podrían ser moderados o eliminados.
Muy popular en Reino Unido
Muy popular en Australia
= de moda


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Green TeaApril 2007
By David Nayor
Scientific research on the health benefits of green tea is expanding exponentially, with more than 1,500 articles published in prestigious journals over the last five years alone.
While green tea's medicinal properties have been described for more than 1,000 years, one of its most timely benefits may be supporting weight management by increasing metabolism and promoting fat burning. With nearly two thirds of the American population now overweight or obese—and thus at heightened risk for metabolic syndrome, heart disease, cancer, and other life-threatening ailments—effective weight-control strategies are fast becoming a matter of life and death.
In addition to promoting healthy body weight and composition, green tea may help ward off numerous health conditions that afflict aging adults, from cataracts to autoimmune disorders. Green tea's health-promoting properties have even been recognized by the FDA, which recently approved the first prescription drug derived from green tea.
In this article, we examine compelling research supporting green tea's role in helping to achieve and maintain a healthy body weight, along with myriad studies testifying to its broad-spectrum effects in promoting optimal health and well-being.
Green Tea Supports Healthy Body Mass and Composition
America's looming obesity epidemic has spurred scientists to seek new agents that promote healthy body weight and composition. Certain spicy foods and herbal drinks have long been used as weight-management tools because of their purported ability to promote thermogenesis or satiety. Scientists have proposed that such agents—like ginger and black pepper—may help prevent excessive weight gain and obesity via these mechanisms.1
During the past decade, green tea has received particular attention for its role in promoting healthy weight management. Its weight-control effects have been studied extensively in cell, animal, and human studies. Laboratory and animal models suggest that green tea, green tea polyphenols known as catechins, and green tea's principal catechin, EGCG, may work to promote healthy weight management by:
At the same time, green tea has been found to increase the oxidation (breakdown) of fats. Human studies suggest that green tea consumption is associated with decreased body mass and body fat.2
Green Tea Promotes Thermogenesis
Earlier research suggested that caffeine in green tea might be responsible for its thermogenic effect. Later studies, however, reported that green tea's thermogenic effects were too great to be attributed to caffeine alone. Instead, scientists proposed that green tea polyphenols may work in synergy with caffeine to promote thermogenesis.8
According to recent findings, EGCG may be an important contributor to green tea's effects in promoting thermogenesis and healthy weight control. Scientists believe EGCG works by inhibiting catechol-O-methyltransferase, an enzyme that degrades norepinephrine. Produced by the adrenal glands in response to stress, the hormone norepinephrine increases metabolic rate, which likely contributes to green tea's effects on thermogenesis.9
Green Tea Inhibits Fat Digestion and Absorption
Several years ago, scientists suggested a possible mechanism by which green tea may guard against excess body weight. In the laboratory, scientists found that a green tea extract inhibited fat-digesting lipase enzymes of the stomach and pancreas. By inhibiting fat-digesting enzymes, green tea likely reduces fat digestion in humans, thus averting some of the dangers of consuming excess fat calories.10
A recent human study provides support for these earlier findings. In a trial published last year in the European Journal of Clinical Nutrition, researchers found that polyphenol-enriched oolong tea (a partially fermented cousin of green tea) helps promote the fecal excretion of lipids following consumption of fatty foods. In a well-designed study, 12 healthy adults consumed a large quantity of fat from potato chips twice daily, along with either a placebo drink or polyphenol-rich tea three times daily. Tea consumption led to an increased fecal excretion of dietary fats, suggesting that tea polyphenols guard against the dangers of excessive dietary fat absorption.11 Based on this study, it might be prudent to take two high-potency green tea capsules, or drink several cups of green tea with fatty meals.
Green Tea Promotes Fat Burning, Supports Healthy Body Weight
An animal study provides important clues to green tea's effects on body weight. Scientists fed mice a high-fat diet in order to induce obesity, and then supplemented the mice with EGCG and monitored biochemical and metabolic changes in the animals. EGCG helped reduce the accumulation of additional body fat, even though food intake remained unchanged. Furthermore, the EGCG-supplemented mice displayed metabolic changes suggestive of increased fat burning. Dietary EGCG consumption thus reduced the gain of fat mass. This may have resulted from increased fat burning, reduced digestibility of dietary fats, or a combination of factors.12
Green Tea Boosts Exercise Capacity
Another animal study suggests that green tea may enhance exercise endurance and fat-burning ability. Scientists noted that when mice were supplemented with green tea extract, their exercise capacity increased substantially. In fact, compared to a control group of animals, mice supplemented with green tea ran 30% longer before becoming exhausted. Additionally, the supplemented mice displayed markers of increased fat oxidation. These findings suggest that green tea improved exercise endurance by increasing the utilization of fatty acids as an energy source during exercise.13
Human Studies Confirm Green Tea's Effects
Additional human studies support green tea's ability to boost metabolism and support healthy weight management.
A study published in the American Journal of Clinical Nutrition found that green tea extract significantly increased energy expenditure (a measure of metabolism) in adults, while also boosting fat burning. When men supplemented with 90 mg of EGCG and 50 mg of caffeine three times daily, their 24-hour energy expenditure increased by 4%. The supplemented men thus burned 79 more calories a day than men who did not supplement. The increase in energy expenditure came from burning fat, as opposed to a breakdown of protein (muscle) mass. These important findings suggest that green tea extract can be an important tool in maintaining healthy body weight and composition.14
Another study lends support to green tea's role in healthy weight control in humans. In this trial, moderately obese adults supplemented with a green tea extract. After three months, they demonstrated a 4.6% decrease in body weight and a 4.5% decrease in waist circumference. This important study demonstrates that green tea effectively supports healthy body mass and protects against dangerous excess weight around the abdomen, which is a potent risk factor for metabolic syndrome.15


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Short Errol Morris film on Benoit Mandelbrot Nov 18 2013
A short time before his death, Benoît B. Mandelbrot filmed an interview with Errol Morris. Morris charmingly starts off my asking Mandelbrot where "the fractal stuff" came from.
Note: as always, the "B." in "Benoît B. Mandelbrot" stands for "Benoît B. Mandelbrot". (via @sampotts)


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TORONTO -- After suffering four straight losses with an offense gone cold, the A's say it's too early for soul searching or a crisis of confidence.
After a 3-1 loss to the Toronto Blue Jays in Sunday's series finale, the key to regaining momentum might be as simple as returning home and regrouping.
"To play a long, even game in Tampa and get in a 2 a.m. and turn around play a night game (followed by two day games), it's tough," catcher Derek Norris said. "A lot of guys, I know, are a little bit sleep deprived. ... But that's the way it goes sometimes. Other teams have to battle, too."
Toronto opened the scoring in the fourth inning, when Edwin Encarnacion launched a fastball from A's starter Drew Pomeranz high into the left field stands.
The following inning two singles and a walk loaded the bases, chased Pomeranz from the game and brought up Jose Bautista, who stroked a single off reliever Jim Johnson.
Kevin Pillar scored to push the Blue Jays' lead to 2-0, but an on-target throw from left fielder Yoenis Cespedes nailed Jose Reyes at the plate. The Blue Jays added a third run in the seventh, when Reyes scored on Bautista's sacrifice fly.
Oakland scored in the eighth, when Josh Donaldson drove a Dustin McGowan fastball 420 feet over center field fence. Donaldson's homer represented all the A's offense Sunday, and highlighted the problem that has plagued them all week.
Heading into Friday the A's averaged a league-high 5.1 runs a game, and by Sunday morning had the seventh fewest strikeouts (346).
But on Sunday, Blue Jays starter J.A. Happ struck out seven in seven innings. And over the three-game series, Oakland managed just five runs. In the six games since the start of their series against Tampa Bay, the A's have averaged just 2.2 runs a game.
The A's offensive slump arrived as they tackled a Blue Jays team that has ridden a monthlong hot streak to the top of the American League East. Toronto has scored first in nine of its last 10 games, going 9-1 over that span.
"Teams have caught us when we're hot," A's manager Bob Melvin said. "We caught them when they're hot, and they handed it to us."
Pomeranz entered Sunday with a minuscule 0.94 ERA and a 15-inning shutout streak, but he faltered in the fourth and fifth innings. Encarnacion's homer ended the scoreless streak at 18 innings, and the Blue Jays threatened to score more, loading the bases before an inning-ending double play.
"I might have tried to locate (pitches) a little too much instead of going right at guys," Pomeranz said. "I ended up walking too many people and being in bad counts a lot."
Detroit (Drew Smyly 2-2) at A's (Tommy Milone 2-3), 1:05 p.m. CSNCA


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January 19, 2006
You could call them a modern day Bonnie and Clyde. Investigators say the couple is responsible for several armed robberies on both sides of the river. But what may surprise you is who investigators say did the actual hold-up.
Myoung Shouse has operated this corner store on Eve Street for about 10 months and will all of the customers that come in her store, she will never forget the eyes of this woman.
"When she came in she put the ski mask on, but I could see her eyes," Shouse said.
Shocked that she was being robbed, but even more shocking was the person doing the holdup.
"First time I thought she was just playing around and I ask her what are you doing?" Shouse said. "She just come in through and she pointed the gun and she say give me money," Shouse said.
Investigators say 27-year-old Sandy Akin is responsible for at least two other robberies in Richmond County. Witnesses report that 27-year-old Charles Collins was her partner as the getaway driver. Aiken Public Safety Sergeant David Turno says the same scenario in Richmond County played out at Kangaroo Express in Aiken just last week.
"In our robbery here in Aiken she wore a ski mask, but she didn't put that on until she was at the door of the store so people saw her walking up to the store," Turno said.
And with similar descriptions, a woman committing the armed robbery and a man driving away, Aiken and Richmond Counties realized they had something in common.
"The female in particular being the one go on armed is different," Turno said.
And because it was so unusual, investigators believed they had a link.
No one was injured in any of the four robberies. District Attorney Danny Craig and Aiken County Solicitor Barbara Morgan are discussing how they will prosecute the couple since they are involved in crimes in Richmond County and Aiken County.


text:
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a credit or refund.


text:
|SR19 - Home Page
Release 19
NOTE: This release of the USDA Nutrient Database for Standard Reference has been superseded. The current release is SR28. Access to Release 19 of the USDA Nutrient Database for Standard Reference is provided here for those users who may wish to use it for historical reasons.
The suggested citation for this database is:
SR19 documentation describing all the files, their fields and relationships accompanies the database and can be viewed online.


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By Kevin Siembieda
Life at Palladium Books remains busy and more than a little crazy. Every day we have an agenda – a list of things to do – and every day there seems to be something that demands our immediate attention and pulls us in different directions. For example, we wanted this Update posted on Thursday. That was not possible. To get one posted today, Friday, it will have to be less comprehensive than we wanted it to be. Fear not, there will be more in the next Weekly Update.
UPDATE: To China and back
Wayne Smith's trip to China was a productive one. While he was there, the Third Container of product for Robotech® RPG Tactics™ was packed and prepped for shipping. It leaves port this coming Monday (September 15). The Second Container is already at sea and on its way to us. Containers Number Four and Five will shipping soon, maybe even together. Everything seems to be moving along better and faster. Hopefully, these next few containers are not held up at Customs!!!
Wayne enjoyed the trip, learned a good deal about the factories and manufacturing processes, and he wished the visit was longer. I hope Wayne will post a number of photographs here and on the Palladium Facebook Page. Poor Wayne has been dragging and pretty jet-lagged the first part of the week. It wasn't until Thursday and today that he appears to be mostly back to his old self and back up to speed.


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Dancing On Ice contestant Angela Rippon prepares at Queens!
2010-12-04 22:08:04
Former Dancing On Ice Judge Angela Rippon is practicing hard on the rink at Queens in preparation for her imminent appearance, this time as a contestant...
We'd like to wish you the best with the competition Angela!
Read further press here:
The Press Association, 25th Nov 2010


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'Not helping'
Published: Wednesday, January 23, 2013 at 7:41 a.m.
Last Modified: Wednesday, January 23, 2013 at 7:41 a.m.
Lula Scruggs of the Cooley Springs community just over the border in South Carolina was doing some shopping in Hendersonville the other day, and given the opportunity to speak what's on her mind, she zeroed in on government. "Our government doesn't know what it is doing," she declares. "It is depressing. It doesn't seem to know that you can't spend more money than what you take in, and President Barack Obama may think he relates to the poor folks, but he's not helping with the things he is doing. I have a friend who voted for him, and I just tell her to be sure and explain to the kids when they complain to Mama."
'NO MORALS': Rachel Jackson of Edneyville is disturbed by today's world: "People have no morals, no responsibility, no concern for others. They are leaving God out of their lives, and when we leave him out, this is what happens. Things will continue to go wrong until we put God back into our lives. Until then, we will not see peace and happiness."
'THE FIRST THING': Making the Internet rounds is a tale sure to bring down the house with laughter. The story begins on a night outside a small town in Wyoming. A fire had started inside a chemical plant, and in the blink of an eye, it exploded into massive flames. The alarm went out to all the fire departments for miles around. When the volunteer firefighters arrived, the chemical company president rushed over and said, "All of our secret formulas are in the vault in the center of the plant. I will give $50,000 to the fire department that brings them out intact." But the roaring flames held the firefighters off. Soon more fire departments had to be summoned as the situation became desperate. As the firefighters arrived, the president shouted out that he would increase his offer to $100,000. From the distance, a lone siren was heard as another firetruck came into sight. It was from a small nearby township, and the town's only firetruck, a vintage 1950s vehicle, roared right past all the newer engines parked outside the plant and sped straight into the middle of the inferno. The firefighters on that old truck jumped off right in the middle of the fire and fought it back on all sides. It was a performance and effort never seen before. Within a short time, the heroes had extinguished the fire and had saved the secret formulas. The grateful chemical company president increased the reward to $200,000. A local newspaper reporter rushed over to interview the chief. "What are you going to do with all that money?" the reporter asked. "Well," said the chief, "the first thing we're going to do is fix the brakes on that firetruck."
PERFECT MATE: At the coffeehouse, a young woman was telling friends her idea of the perfect mate. "The man I marry must be a shining light. He must be musical, sing, tell jokes and stay home at night." An old-timer piped up: "Sweetheart, if that's all you want, get a television."
LAST BUT NOT LEAST: Come on out to Historic Johnson Farm on Saturday, from 10 a.m. to 3 p.m., to experience the fun of the second annual Fiber Expo sponsored by the Heritage Weavers and Fiber Artists. The event will be held in the white clapboard building formerly known as the boarding house. Lessons in weaving, knitting, crocheting, bobbin lace, rug hooking, spinning and inkle weaving are held throughout the year and will be demonstrated during Fiber Expo. A highlight of this year's expo is a display honoring former local resident Bessie Jordan and her many years of dedication to perfecting the craft of weaving. She taught in Henderson County schools for many years and served as a principal for some of that time. On display in the boarding house will be one of her looms, examples of her weaving skill and replicas of the intricate weaving patterns she collected on her travels around the country.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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During the past few weeks, every time Ana Marie Acosta was riding in one of the Tournament of Roses mini-vans back to the Tournament House after an event, she peeked behind her shoulder as the van turned left onto Orange Grove -- and Colorado Boulevard was in full view.
"Oh my God, it's going to be full of people," she said, speaking of Jan. 1 when about 500,000 people will line the street to view the 125th Rose Parade.
Not only that, all those people will be looking at her, the Rose Queen, as she rides a float with members of her Royal Court.
"I can't even wait," the 17-year-old Polytechnic student said. "I get chills whenever I talk about it."
Acosta, an Altadena resident, grew up wanting to be Rose Queen and her mother has proof. Sarah Acosta saved photographs of young Ana posing with Rose Queens throughout the years, just in case this moment came.
"It really was a dream come true," said Sarah Acosta, playing on the theme of this year's parade, "Dreams Come True."
Queen Ana has loved posing for pictures with young girls at different events the Royal Court has attended over the past few weeks. Not that long ago, she was the little girl wanting to meet the Queen and Princesses.
"Now, every time I take a picture with a little girl, I think maybe in 10 years she's going to come back and show me this picture," Ana said.
Ana is proud to be a "Poly girl." She is the first person from her school to be Rose Queen since 1995.
When she was selected as one of the seven members of the Royal Court, her friends prepared a photo slideshow for the school's morning assembly and presented Queen Ana with a crown and flowers.
"Getting to show off Poly has been a lot of fun for me," Acosta said. "They're really rooting for me."
Acosta was dressed in a red blouse and black riding trousers, with tall boots and a string of pearls for a recent interview at the Tournament House. She is an avid horseback rider and two-time captain of her school's equestrian team.
Acosta said she was drawn to the sport inspired by her late grandfather who owned a ranch in Cuba.
"Getting to ride has been a connection to him that I didn't have after he died," she said.
The self-described Rose Court team captain has a game plan to tackle to the grueling schedule the day of the parade, which will have her being picked up from her home around 1 or 2 a.m.
"I plan to take a lot of naps," she said.
Acosta loves watching the ball drop in New York's Times Square on television, so she doesn't want to miss the New Year's Eve tradition.
"I might fall asleep while they do my hair," she said, laughing.
Balancing Tournament duties on top of schoolwork, college applications and extra-curricular activities has been a challenge and will sometimes mean Acosta has been up until 3:30 a.m. for several weeks to get everything done.
"If you look at what I've done in the past, I've always been that kid who wants to do 10 things at once," she said.
The queen and royal princesses will often designate a room in the Tournament House as the "study room" where they do homework in between training or preparations for their next event.
But soon, talking and laughing will ensue, and within 30 minutes of one room being designated the "study room" another room will be designated as a quiet place for school work.
Acosta says there is no rivalry between the six princesses and the queen.
"We're really new sisters to each other because we spend so much time together," she said. "It happened so fast. I already love them for who they are."
While Queen Ana will be relishing in her moment in the spotlight during the parade, the 100th Rose Bowl Game will be less familiar territory.
She doesn't know much about football, but hopes some of her friends will give her a crash course.
"So I know what's going on," she said.
Acosta, who hopes to study medicine, likely at an East Coast school next year, said the Rose Court experience has connected her to Pasadena in a unique way.
"When you get involved in something in Pasadena, it lasts," she said. "It's been nice seeing that and seeing how much pride everybody has in the city."


text:
Tottenham Hotspur Message Board
Strange pre-season
This is a bit of an odd pre-season eh? £61m already spent and about £20m back in sales. That's a hefty old whack for a nett spend with some 18 days still to go.
So T'Hudd (perm) has now gone, along with Livermore (loan) and the rumours abound that Scottie and Townsend are also potentially, maybe, could be going. I still wouldn't be surprised to see Ade/Daffy both/either go. Danny Rose has also said he now feels that it's time to play on a regular basis. I think AVB needs to look at the 'home grown' balance before deciding on too many more exits. If the transfers/loans so far, all the incoming are foreign and 14/18 of the players on the outgoing list are English.
A couple of seasons back we looked good on the 'home' front - now looking at the England set up, I don't see many of our squad making that apart from Walker. I think Daws could have just made it, had it not been for the injuries at critical times. Daffy - I'm not sure, as going on last nights set up, he may have fallen further down the order, and if he doesn't get regular games next season, then I don't see him going to the WC.
I always though Levy was a 'young - and maybe British' type buyer - seems a bit of a departure so far.Sort: Newest | Oldest | Most Replied Expand all replies
still rumours of people coming like Erikson and the other fella from Ajax i cant remember his name atm i think Levy has finally realised we needed to spend to compete at the top and the signings so far have been top notch Paulinho looked aswesome in pre season fantastic first touch high quality passing plenty of pace and skill.
RToday is the day the season is upon us roll on the end of the transfer window so the whole Bale situation can be sorted out one way or another and we can get on with our new season.
- 1 Reply to Cockney
I think we'll get another striker before the window shuts. I'm hoping we can get Erik Lamela from Roma, but valued at £20-£30m so probably to costly for us, although wer'e been in talks apparently.


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Both rosters have been submitted. There were 3 guys who are still maybes, so there may be a few changes, but I suspect they will be in. The teams should get updated later today. Didnt leave anybody out on purpose. These names came to mind, and were suggested by others. Im sure in the coming days Ill find a few people that may have been a better fit here and there, but it is what it is. Ill give those guys a little time to decide, and then Ill work on the best doubles/ quads lineups.
Feel free to find me on the course and punch me in the face if you feel you deserve a spot... Ill tell you all about how Im organizing the teams, and not playing, and give you a little sad story in return


text: One of my favorite places in Berkeley is Urban Ore, a giant salvage yard located just across the Bay from downtown San Francisco. I can't imagine anything further than the glamor and relentless newness of San Francisco; Urban Ore is all about old, dusty, funky things, and it seems like an odd place for a finicky person like me to spend so much time. See full article.


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JT Tech Show Featuring AkihabaraNews: Interview with Molcure's Eli Lyons (PODCAST)
The JT Tech Show with Reno J. Tibke, Presented by Japan Today
The JT Tech Show with Reno J. Tibke, Presented by Japan Today
King Jim is going to release a pair of digital noise canceling earplugs on March 7.
The digital earplugs are able to shut out ambient noise, however they don't shut out all the sounds around you. It lets you hear important sounds like a public announcement, incoming call, and somebody's voice talking to you.
Fujitsu just introduced a new PC series specially targeting over 60-year-old people, called GRANNOTE. The first product in the series, Windows 8.1 LIFEBOOK AH90/P will be released on February 13.
Fujitsu applied their Human Centric Engine, which is already being used in their smartphones, to PCs for the first time. Human Centric Engine is their own technology that helps make operations through technology easy for users and adapts to users and their usage environments.
Expensive Ultrabook PC, but it can rotate VERY well
Thanks to Thanko, now you can develop your muscles secretly in the office without your co-workers noticing!
A computer mouse and EMS (Electrical Muscle Stimulation) have been merged cleverly in the Wireless Muscle Mouse that has just been released by Thanko.
Taiko no Tatsujin comes home (If you have V-Drums and iPad)!
Bandai Namco's Japanese drum rhythm arcade game, Taiko no Tatsujin, is now playable on Roland's electronic drumset series V-Drums. Roland is a Japanese electronic musical instruments manufacturer.
Terrie's Take is a selection of Japanese-centric news collected and collated by long-time resident and media business professional Terrie Lloyd. AkihabaraNews is pleased to present Terrie's learned perspective; we all could use another take on the news - here's Terrie's:
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Sony Music Entertainment just started a music performance video audition called Sony MUSIC VIDEO AUDITION "REC" today, and they will accept applications until March 31.
This is an audition to compete for singing ability, power of expression, and on visual points. Not limited in terms of nationality, age, sex, genre, category, etc., Sony Music Entertainment is aiming to discover new character and talent. So, of course, those who live outside of Japan can also apply for the audition.
This year is the 30th anniversary of the release in Japan of internationally loved ice cream brand, Häagen-Dazs.
To celebrate it, today they released 2 new seasonal flavors - 30th Anniversary Sakura (Sakura means cherry blossom in Japanese) and 30th Anniversary Rose. These 2 flavors are Häagen-Dazs's first flower-flavored ice creams.
Powdered cherry blossom petals, cherry sauce and salt are mixed in the softly-pink-colored Sakura flavored ice cream. It also has Sakura flavored sauce topping.


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Newly-elected Congressman Jason Smith will visit Phelps and Crawford counties this Monday, July 1.
His stops in the two counties will include tours of plants as well as a roundtable discussion with business leaders in Rolla.
From 11 a.m. to noon, Smith will tour Tacony Manufacturing on Industrial Drive in St. James and meet with employees there.
From 12:15-1:30 p.m., he will hold the roundtable discussion at Rolla's Innovation Park off 10th Street.
Earlier in the day, Smith is also scheduled to visit Meramec Electrical Products and American Precision Die Casting, both in Cuba, Mo.
Location, ST | website.com


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Sniff, sniff….what is that smell?
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Nashua man mows Bruins logo on his lawn
�The lawn is my canvas, and the mower is my paintbrush,� Boucher said. �I have no art background. I have a head for numbers and good perception.�
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Web design using grids NOV 05 2010
Khoi Vinh has a new book coming out next month called Ordering Disorder: Grid Principles for Web Design.
"Ordering Disorder" is an overview of all of my thoughts on using the typographic grid in the practice of Web design. The first part of the book covers the theories behind grid design, the historical underpinnings of the grid, how they're relevant (and occasionally irrelevant) to the work of Web designers -- and a bit of my personal experience coming to grips with grids as a tool.
The second part of the book, which makes up its bulk, walks readers through the design of a full Web site from scratch, over the course of four projects.
Vinh did the art direction for the book himself, so it's bound to be purty (and grid-y). The perfect early holiday gift for the web designer in your life.


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HomeGeneral InformationRegenerative MedicineAre Stem Cells Involved in Cancer?
Charles A. Goldthwaite, Jr., PhD.
Data from 2007 suggest that approximately 1.4 million men and women in the U.S. population are likely to be diagnosed with cancer, and approximately 566,000 American adults are likely to die from cancer in 2008.1 Data collected between 1996 and 2004 indicate that the overall 5-year survival rate for cancers from all sites, relative to the expected survival from a comparable set of people without cancer, is 65.3%.1 However, survival and recurrence rates following diagnosis vary greatly as a function of cancer type and the stage of development at diagnosis. For example, in 2000, the relative survival rate five years following diagnosis of melanoma (skin cancer) was greater than 90%; that of cancers of the brain and nervous system was 35%. Once a cancer has metastasized (or spread to secondary sites via the blood or lymph system), however, the survival rate usually declines dramatically. For example, when melanoma is diagnosed at the localized stage, 99% of people will survive more than five years, compared to 65% of those diagnosed with melanoma that has metastasized regionally and 15% of those whose melanoma has spread to distant sites.2
The term "cancer" describes a group of diseases that are characterized by uncontrolled cellular growth, cellular invasion into adjacent tissues, and the potential to metastasize if not treated at a sufficiently early stage. These cellular aberrations arise from accumulated genetic modifications, either via changes in the underlying genetic sequence or from epigenetic alterations (e.g., modifications to gene activation- or DNA-related proteins that do not affect the genetic sequence itself).3,4 Cancers may form tumors in solid organs, such as the lung, brain, or liver, or be present as malignancies in tissues such as the blood or lymph. Tumors and other structures that result from aberrant cell growth, contain heterogeneous cell populations with diverse biological characteristics and potentials. As such, a researcher sequencing all of the genes from tumor specimens of two individuals diagnosed with the same type of lung cancer will identify some consistencies along with many differences. In fact, cancerous tissues are sufficiently heterogeneous that the researcher will likely identify differences in the genetic profiles between several tissue samples from the same specimen. While some groupings of genes allow scientists to classify organ-or tissue-specific cancers into subcategories that may ultimately inform treatment and provide predictive information, the remarkable complexity of cancer biology continues to confound treatment efforts.
Once a cancer has been diagnosed, treatments vary according to cancer type and severity. Surgery, radiation therapy, and systemic treatments such as chemotherapy or hormonal therapy represent traditional approaches designed to remove or kill rapidly-dividing cancer cells. These methods have limitations in clinical use. For example, cancer surgeons may be unable to remove all of the tumor tissue due to its location or extent of spreading. Radiation and chemotherapy, on the other hand, are non-specific strategies—while targeting rapidly-dividing cells, these treatments often destroy healthy tissue as well. Recently, several agents that target specific proteins implicated in cancer-associated molecular pathways have been developed for clinical use. These include trastuzumab, a monoclonal antibody that targets the protein HER2 in breast cancer,5 gefitinib and erlotnib, which target epidermal growth factor receptor (EGFR) in lung cancer,6 imatinib, which targets the BCR-ABL tyrosine kinase in chronic myelogenous leukemia,7 the monoclonal antibodies bevacizumab, which targets vascular endothelial growth factor in colorectal and lung cancer,8 and cetuximab and panitumumab, which target EGFR in colorectal cancer.8 These agents have shown that a targeted approach can be successful, although they are effective only in patients who feature select subclasses of these respective cancers.
All of these treatments are most successful when a cancer is localized; most fail in the metastatic setting.9–11 This article will discuss the CSC hypothesis and its supporting evidence and provide some perspectives on how CSCs could impact the development of future cancer therapy.
A consensus panel convened by the American Association of Cancer Research has defined a CSC as "a cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor."12 It should be noted that this definition does not indicate the source of these cells—these tumor-forming cells could hypothetically originate from stem, progenitor, or differentiated cells.13 As such, the terms "tumor-initiating cell" or "cancer-initiating cell" are sometimes used instead of "cancer stem cell" to avoid confusion. Tumors originate from the transformation of normal cells through the accumulation of genetic modifications, but it has not been established unequivocally that stem cells are the origin of all CSCs. The CSC hypothesis therefore does not imply that cancer is always caused by stem cells or that the potential application of stem cells to treat conditions such as heart disease or diabetes, as discussed in other chapters of this report, will result in tumor formation. Rather, tumor-initiating cells possess stem-like characteristics to a degree sufficient to warrant the comparison with stem cells; the observed experimental and clinical behaviors of metastatic cancer cells are highly reminiscent of the classical properties of stem cells.9
The CSC hypothesis suggests that the malignancies associated with cancer originate from a small population of stem-like, tumor-initiating cells. Although cancer researchers first isolated CSCs in 1994,14 the concept dates to the mid-19th century. In 1855, German pathologist Rudolf Virchow proposed that cancers arise from the activation of dormant, embryonic-like cells present in mature tissue.15 Virchow argued that cancer does not simply appear spontaneously; rather, cancerous cells, like their non-cancerous counterparts, must originate from other living cells. One hundred and fifty years after Virchow's observation, Lapidot and colleagues provided the first solid evidence to support the CSC hypothesis when they used cell-surface protein markers to identify a relatively rare population of stemlike cells in acute myeloid leukemia (AML).14 Present in the peripheral blood of persons with leukemia at approximately 1:250,000 cells, these cells could initiate human AML when transplanted into mice with compromised immune systems. Subsequent analysis of populations of leukemia-initiating cells from various AML subtypes indicated that the cells were relatively immature in terms of differentiation.16 In other words, the cells were "stem-like"—more closely related to primitive blood-forming (hematopoietic) stem cells than to more mature, committed blood cells.
The identification of leukemia-inducing cells has fostered an intense effort to isolate and characterize CSCs in solid tumors. Stem cell-like populations have since been characterized using cell-surface protein markers in tumors of the breast,17 colon,18 brain,19 pancreas,20,21 and prostate.22,23 However, identifying markers that unequivocally characterize a population of CSCs remains challenging, even when there is evidence that putative CSCs exist in a given solid tumor type. For example, in hepatocellular carcinoma, cellular analysis suggests the presence of stem-like cells.24 Definitive markers have yet to be identified to characterize these putative CSCs, although several potential candidates have been proposed recently.25,26 In other cancers in which CSCs have yet to be identified, researchers are beginning to link established stem-cell markers with malignant cancer cells. For instance, the proteins Nanog, nucleostemin, and musashi1, which are highly expressed in embryonic stem cells and are critical to maintaining those cells' pluripotency, are also highly expressed in malignant cervical epithelial cells.27 While this finding does not indicate the existence of cervical cancer CSCs, it suggests that these proteins may play roles in cervical carcinogenesis and progression.
Given the similarities between tumor-initiating cells and stem cells, researchers have sought to determine whether CSCs arise from stem cells, progenitor cells, or differentiated cells present in adult tissue. Of course, different malignancies may present different answers to this question. The issue is currently under debate,9,12 and this section will review several theories about the cellular precursors of cancer cells (see Fig. 9.1).
Figure 9.1. How Do Cancer Stem Cells Arise? The molecular pathways that maintain "stem-ness" in stem cells are also active in numerous cancers. This similarity has led scientists to propose that cancers may arise when some event produces a mutation in a stem cell, robbing it of the ability to regulate cell division. This figure illustrates 3 hypotheses of how a cancer stem cell may arise: (1) A stem cell undergoes a mutation, (2) A progenitor cell undergoes two or more mutations, or (3) A fully differentiated cell undergoes several mutations that drive it back to a stem-like state. In all 3 scenarios, the resultant cancer stem cell has lost the ability to regulate its own cell division.
© 2009 Terese Winslow
Cancer Cells Arise from Stem Cells. Stem cells are distinguished from other cells by two characteristics: (1) they can divide to produce copies of themselves, or self-renew, under appropriate conditions and (2) they are pluripotent, or able to differentiate into most, if not all, mature cell types. If CSCs arise from normal stem cells present in the adult tissue, de-differentiation would not be necessary for tumor formation. In this scenario, cancer cells could simply utilize the existing stem-cell regulatory pathways to promote their self-renewal. The ability to self-renew gives stem cells long lifespans relative to those of mature, differentiated cells.30 It has therefore been hypothesized that the limited lifespan of a mature cell makes it less likely to live long enough to undergo the multiple mutations necessary for tumor formation and metastasis.
Several characteristics of the leukemia-initiating cells support the stem-cell origin hypothesis. Recently, the CSCs associated with AML have been shown to comprise distinct, hierarchically-arranged classes (similar to those observed with hematopoietic stem cells) that dictate distinct fates.31 To investigate whether these CSCs derive from hematopoietic stem cells, researchers have used a technique known as serial dilution to determine the CSCs' ability to self-renew. Serial dilution involves transplanting cells (usually hematopoietic stem cells, but in this case, CSCs) into a mouse during a bone-marrow transplant. Prior to the transplant, this "primary recipient" mouse's natural supply of hematopoietic stem cells is ablated. If the transplant is successful and if the cells undergo substantial self-renewal, the primary recipient can then become a successful donor for a subsequent, or serial, transplant. Following cell division within primary recipients, a subset of the AML-associated CSCs divided only rarely and underwent self-renewal instead of committing to a lineage. This heterogeneity in self-renewal potential supports the hypothesis that these CSCs derive from normal hematopoietic stem cells.31 It should be noted, however, that the leukemia-inducing cells are the longest-studied of the known CSCs; the identification and characterization of other CSCs will allow researchers to understand more about the origin of these unique cells.
The differentiation pathway from a stem cell to a differentiated cell usually involves one or more intermediate cell types. These intermediate cells, which are more abundant in adult tissue than are stem cells, are called progenitor or precursor cells. They are partly differentiated cells present in fetal and adult tissues that usually divide to produce mature cells. However, they retain a partial capacity for self-renewal. This property, when considered with their abundance relative to stem cells in adult tissue, has led some researchers to postulate that progenitor cells could be a source of CSCs.32,33
Some researchers have suggested that cancer cells could arise from mature, differentiated cells that somehow de-differentiate to become more stem celllike. In this scenario, the requisite oncogenic (cancer causing) genetic mutations would need to drive the de-differentiation process as well as the subsequent self-renewal of the proliferating cells. This model leaves open the possibility that a relatively large population of cells in the tissue could have tumorigenic potential; a small subset of these would actually initiate the tumor. Specific mechanisms to select which cells would de-differentiate have not been proposed. However, if a tissue contains a sufficient population of differentiated cells, the laws of probability indicate that a small portion of them could, in principle, undergo the sequence of events necessary for de-differentiation. Moreover, this sequence may contain surprisingly few steps; researchers have recently demonstrated that human adult somatic cells can be genetically "re-programmed" into pluripotent human stem cells by applying only four stem-cell factors (see the chapter, "Alternate Methods for Preparing Pluripotent Stem Cells" for detailed discussion of inducing pluripotent stem cells).28,29
Metastasis is a complex, multi-step process that involves a specific sequence of events; namely, cancer cells must escape from the original tumor, migrate through the blood or lymph to a new site, adhere to the new site, move from the circulation into the local tissue, form micrometastases, develop a blood supply, and grow to form macroscopic and clinically relevant metastases.9,34,35 Perhaps not surprisingly, metastasis is highly inefficient.9 It has been estimated that less than 2% of solitary cells that successfully migrate to a new site are able to initiate growth once there.34,36,37 Moreover, less than 1% of cells that initiate growth at the secondary site are able to maintain this growth sufficiently to become macroscopic metastases.36 These observations suggest that a small, and most likely specialized, subset of cancer cells drives the spread of disease to distant organs.
Some researchers have proposed that these unique cells may be CSCs.9,30,32,33,38 In this hypothesis, metastatic inefficiency may reflect the relative rarity of CSCs combined with the varying compatibilities of these cells with destination microenvironments. Researchers have demonstrated that stem cells and metastatic cancer cells share several properties that are essential to the metastatic process, including the requirement of a specific microenvironment (or "niche") to support growth and provide protection, the use of specific cellular pathways for migration, enhanced resistance to cell death, and an increased capacity for drug resistance.9 There is emerging, albeit limited, evidence that these properties may also hold for CSCs.9 Metastatic sites for a given cancer type could therefore represent those tissues that provide or promote the development of a compatible CSC niche, from which CSCs could expand through normal or dysregulated cellular signaling. Moreover, normal stem cells tend to be quiescent unless activated to divide.39 If the CSC hypothesis holds true, then undifferentiated, dormant CSCs would be relatively resistant to chemotherapeutic agents, which act mainly on dividing cells.10 As such, this subpopulation could form the kernel of cells responsible for metastasis and cancer recurrence following treatment and remission.
As noted previously, most contemporary cancer treatments have limited selectivity — systemic therapies and surgeries remove or damage normal tissue in addition to tumor tissue. These methods must therefore be employed judiciously to limit adverse effects associated with treatment. Moreover, these approaches are often only temporarily effective; cancers that appear to be successfully eliminated immediately following treatment may recur at a later time and often do so at a new site. Agents that target molecules implicated in cancer pathways have illustrated the power of a selective approach, and many researchers and drug developers are shifting toward this paradigm. If the CSC hypothesis proves to be correct, then a strategy designed to target CSCs selectively could potentially stop the "seeds" of the tumor before they have a chance to germinate and spread.
The CSC hypothesis accounts for observed patterns of cancer recurrence and metastasis following an apparently successful therapeutic intervention. In clinical practice, however, some cancers prove quite aggressive, resisting chemotherapy or radiation even when administered at relatively early stages of tumor progression. These tumors therefore have an increased likelihood of metastasizing, confounding further treatment strategies while compromising the cancer patient's quality of life. The presence of CSC in some malignancies may account for some of these metastases. So why do some tumors succumb to therapy, while others resist it? Some scientists have suggested that the tumor aggressiveness may correlate with the proportion of CSCs within a corresponding tumor.40–42 In this scenario, less aggressive cancers contain fewer CSCs and a greater proportion of therapy-sensitive non-CSCs.9
There is also some evidence to suggest that CSCs may be able to selectively resist many current cancer therapies, although this property has yet to be proven in the clinic.9 For example, normal stem cells and metastatic cancer cells over-express several common, known drug-resistance genes.43 As a result, breast cancer CSCs express increased levels of several membrane proteins implicated in resistance to chemotherapy 17 These cells have also been shown to express intercellular signaling molecules such as Hedgehog and Bmi-1,44 which are essential for promoting self-renewal and proliferation of several types of stem cells.45 Moreover, experiments in cell lines from breast cancer46 and glioma40 have shown that CSCs (as identified by cell-surface markers) are more resistant to radiotherapy than their non-CSC counterparts. In the face of radiation, the CSCs appear to survive preferentially, repair their damaged DNA more efficiently, and begin the process of self-renewal.
These discoveries have led researchers to propose several avenues for treating cancer by targeting molecules involved in CSC renewal and proliferation pathways. Potential strategies include interfering with molecular pathways that increase drug resistance, targeting proteins that may sensitize CSCs to radiation, or restraining the CSCs' self-renewal capacity by modifying their cell differentiation capabilities.9 In each case, successful development of a therapy would require additional basic and clinical research. Researchers must characterize the CSCs associated with a given tumor type, identify relevant molecules to target, develop effective agents, and test the agents in pre-clinical models, such as animals or cell lines. However, by targeting fundamental CSC cellular signaling processes, it is possible that a given treatment could be effective against multiple tumor types.
Cancer represents a major health challenge for the 21st century. Governed by an intricate, complex interplay of molecular signals, cancers often resist systemic treatments. Yet the uncontrolled cellular growth that characterizes cancers may paradoxically hold the key to understanding the spread of disease. It has long been postulated that tumors form and proliferate from the actions of a small population of unique cells. The observation that metastatic cancer cells exhibit experimental and clinical behaviors highly reminiscent of the classical properties of stem cells has led researchers to search for and to characterize "cancer stem cells" believed to be implicated in the cancer process.
The discovery of CSCs in some tumor types has ushered in a new era of cancer research. Cancer stem cell science is an emerging field that will ultimately impact researchers' understanding of cancer processes and may identify new therapeutic strategies. However, much remains to be learned about these unique cells, which as of yet have not been identified in all tumor types. At present, evidence continues to mount to support a CSC Hypothesis—that cancers are perpetuated by a small population of tumor-initiating cells that exhibit numerous stem cell-like properties. Whether or not the Hypothesis ultimately proves true in all cases, understanding the similarities between cancer cells and stem cells will illuminate many molecular pathways that are triggered in carcinogenesis. Thus, the question, "Are stem cells involved in cancer?" has no simple answer. However, the characterization of CSCs will likely play a role in the development of novel targeted therapies designed to eradicate the most dangerous tumor cells, that may be resistant to current chemotherapy regimens, thereby providing researchers and clinicians with additional targets to alleviate the burden of cancer.
Chapter 8 | Table of Contents | Chapter 10
Page citation: Are Stem Cells Involved in Cancer?. In Stem Cell Information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2011 [cited Monday, August 29, 2016] Available at <http://stemcells.nih.gov/info/Regenerative_Medicine/Pages/2006Chapter9.aspx>


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So yesterday I serviced my forks, steering head bearing, put on a new tire and decided to do some tweaking on the suspension settings. But first things first...
If you have never checked your suspension settings (clickers) you should. If you don't have a service manual then take it to the dealer and get it done. Many dealers assume incorrectly that Yamaha accurately sets the suspension on every bike released. I've seen several brand new bikes, both dirt and street, that have clickers set wrong or worse, set differently from right to left forks.
Rickster recently posted a reply that contained this reference:
Front 2 lines
rebound 4 clicks out
compression 7 clicks out
rear preload - hard
rear rebound 3 clicks out
(rear compression is not adjustable on stock shock)
Now I consider those settings to be a bit "harsh". I especially don't like running the rear rebound that stiff. My personal experience is that anytime you adjust suspension clickers to near their limit, performance becomes questionable and the suspension behaves erratically. So I devised compromised settings as follows:
Rider weight: 183 lbs.
Typical Bike Payload: Yamaha side bags and top bag, 25 lbs. added cargo
Riding style: Moderately aggressive, frequent 3-digit speeds, rapid braking and acceleration common.
* Preload, Line-2 (this means one line exposed above the cap, one line flush with the cap/adjuster). Stock setting is Line-3.
* Rebound, 6 clicks out. Stock setting is 12-clicks out. (this is the top adjustment)
* Compression, 8 clicks out. Stock setting is 12-clicks out. (this is the bottom adjustment that protrudes off the side of the fork)
* Preload - Hard (find the lever!)
* Rebound - 6 clicks out. Stock is 10-clicks out. (think of the rear rebound clicker as a right-hand thread)
Wow! The very first thing I noticed yet never expected, was that the bar vibration is reduced. Apparently a lot of the bar vibration comes from the suspension being so soft and allowing small, rapid movements in the fork tubes. The stiffer suspension settings seems to force the tire to soak up a bit more.
No more weebles! I've always hated that "weeble" feel when driving hard into corners, especially high-speed sweepers with elevation transitions. The front tended to "wobble and weave" with a washy feeling that I called "weebling". You know... Weebles wobble but they don't fall down. That somewhat freaky thing seems to be drastically reduced if not gone!
Dive Dive Dive no more! I can now roll hard to a stop and get a smooth return to the top. No more diving of the front end when tapping the brakes for a high-speed corner setup. Just tap the front and the forks settle into slightly lower position with no rebound. You can definitely feel the added wheelbase in the turns. This must be what the 06 guys feel all the time.
Perhaps less tire pressure? I normally run 40 rear, 38 front. I could easily see running 38 rear and 36 front, providing the tires don't do something stupid with mileage. This would give me a slightly better footprint and improved traction.
Overall the new settings have a much crisper, yet not uncomfortable feel. I don't have a lot of twisties to test around here. But this weekend I plan the NorthGA run and we'll see for certain how the new settings play. Yamaha has a well-earned reputation for flexibility in their suspension packages. I would encourage anyone interested in doing some careful experimentation. CHECK AND RECORD YOUR EXISTING SETTINGS, KNOW WHAT YOUR STOCK SETTINGS SHOULD BE, WRITE DOWN YOUR CHANGES. All it takes is two minutes and a screwdriver to set everything back if you don't like it.


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Enjoy 15 Tea Pouches of Green Tea Tropical in a stylish black tin. Green Tea Tropical green tea boasts smooth green tea leaves that harmoniously blend with sweet tropical fruits to create a sensation as uplifting as a breeze off the isle of Papenoo. A healthy and refreshing blend rich in antioxidants, Green Tea Tropical makes ideal an introduction to green tea. We sourced the finest loose leaf green tea to infuse our silken tea pouch, our twist on the gourmet teabag, with an extraordinary flavor experience.
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