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From ArachneWiki
Polymorphism is a phenomenon in which a genome contains two or more versions of the same sequence or set of sequences. Polymorphism arises due to the multiplicity of chromosomes in a genome: the chromosomes are similar but not identical, and a particular read may be sequenced from any of the similar chromosomes. The different versions are called haplotypes.
The extent of polymorphism in a genome depends on the ploidy. Most eukaryotic species are diploid, meaning that there are two copies of each chromosome; the chromosome pairs split during meiosis and are then recombined during sexual reproduction. Prokaryotic species are generally haploid, with only one copy of each chromosome, and therefore exhibit no polymorphism. Inbred populations (such as the laboratory mouse) are also effectively haploid due to the lack of genetic diversity.
Types of polymorphism
Before getting into the question of how to actually assemble polymorphic genomes, we want to draw attention to the fact that there are very different incarnations:
- SNPs (Single Nucleotide Polymorphisms)
- Indels
- Inversions and re-arrangements
In addition, DNA sequence can be very different in some cases, e.g. in some sexual fungi (like C.albicans), one allele contains the male version of a gene, and the other one the female version.
Also, the extent of polymorphic events -- the polymorphism rate -- must be taken into account: high SNP density and/or short indels poses one kind of challenge, larger indels and re-arrangements another (since then certain regions are only represented at half coverage in the data set and half the inserts linking across this region will appear stretched or illogical).
Lastly, heterozygosity is not typically distributed evenly in most genomes. In the fish Stickleback, for example, the overall polymorphism rate is an estimated 0.8%, but long stretches appear to be homozygous, so that the remaining parts are polymorphic at a much higher rate.
Assembling polymorphic genomes
When assembling (and representing) a polymorphic genome, there is a major question. Should the haplotypes be represented as two completely distinct sequences? Or should the genome be represented as a single unit, with short branches and splits for the haplotypes? In the former case, connectivity is a hindrance. More read coverage means larger contigs and scaffolds; this suggests that the assembly should be squeezed together, both haplotypes assembled into one, even though this is (quite literally) sometimes a stretch. On the other hand, experience (e.g. C. albicans, L. elongisporus) showed that it can pose enormous difficulties to gene calling when the consensus sequence is derived from a mishmash of both haplotypes: you get everything from false frameshifts to false premature stop codons, even looking for real ORFs becomes impossible.
Ideally, one would like to represent both haplotypes seperately, but this is in most cases not possible. Therefore, in Arachne, we tried to find a compromise.
Getting started
In our experience, it is a good idea to start with an initial assembly, run with default parameters. Depending on the genome, Assemblez's built-in tolerance for polymorphism might yield an acceptable draft assembly (which might need some attention for other reasons). Even in the worst case, it will provide a good starting point for examining the genome and decide which subsequent operations to perform. Perhaps the first thing to look at is the repeat structure: if, due to high polymorphism, the haplotypes ended up assembled in separate contigs or scaffolds, these will appear as repeats (which in some sense, they are), at a multiplicity of 2.
Aggressive scaffolding
In order to extend scaffolds, scaffolding requires contigs to align if insert links suggest that there is an overlap before making joins. If sequence is present in one allele but missing in the other, this can prevent joins from being made. Also, if the haplotypes are two far diverged in certain hotspots, alignments may exist but are rejected as not being good enough. However, having good scaffolds is prerequisite to having good contigs, since contig merges rely on the fact that they are well ordered relative to each other. So, tuning the various parameters to be more lenient should be a good start.
To be even more aggressive, the module MergeHaplotypes will join scaffolds not based on insert linking but strictly on contig-to-contig alignments.
Merging haplotypes
After the scaffold structure is in place, the obvious thing to do is to merge sequence from both haplotypes; As a first step, the module SquashOverlaps takes care of contigs that are entirely subsumed in another by removing this contig and aligning its reads to the subsuming contig with very lenient parameters. A subsequent run of contig gap stuffing (i.e. various forms of merging or bridging gaps between contigs, see for details in that section) will succeed in increasing the connectivity of the assembly.
However, when doing this, there are two things that need to be monitored very carefully:
- Read usage
- Clusters of SNPs and indels
If, in the process, overall read usage drops dramatically when going from an unmerged assembly to a merged one, then this might be a sign that there are too few reads to hold scaffolds together; running BreakUnlinked will break scaffolds in spots that are not spanned by insert linking.
Clusters of disagreements can have bad side effects when computing contig consensus, since there might be many crosses between the two haplotypes too close together, which will have negative effects on e.g. gene calling (see Frankentyping).
When merging haplotypes, it is easily possible to end up with consensus sequence that is too artificial a mix: when making transitions within genes, false frame shifts or stop codons might apper. In C. tropicalis, for example, a diploid fungus, there were 994 genes affected that could not be identified correctly as functional genes. After "separating" the haplotypes (a process we call "frankentyping" since we still have a mix of both haplotypes), this number went down to 116.
So, how to separate the haplotypes? As a first step, we remove all read pairs in which at least one end read has high-quality disagreements with other overlapping reads. We then use a greedy algorithm to place back reads avoiding high-quality disagreements, thus populating the contigs but increasing the distance between spots in which we cross the haplotypes. Re-computing the consensus then will be a better reflection of what one haploid genome could look like.
As a last step, all reads that were not placed back can be assembled again, allowing for some estimate of the second haplotype relative to the 'main' assembly.
Estimating Overall Polymorphism
The polymorphism rate (and nature) between the two haplotypes of a diploid genome can vary quite dramatically, so it is desirable to have a tool which can assess and quantify overall statistics for the entire genome. The relevant information to be used is:
- Where are the repeats (output of TagRepeats)
- Where are the polymorphic events (output of HQDAnnotator)
PolymorphismEstimator combines this information: since we do not want to have an artificially high rate arising from misassembled repetitive regions, we exclude all regions that are marked as repeats or 48 bases away from repeats. Next, we require at least three reads to (consistently with each other) disagree with consensus, where the disagreement can be a single nucleotide polymorphism (SNP) or a short indel (less than 42 bases).
Note: even for haploid genomes, there is some background noise due to either systematic [[sequencing error]s, falsely corrected reads, or other artifacts. This background is typically around 0.001% (or one in 100,000 bases), consistent with an average base quality of about 50.
This metric, however, only captures polymorphism on a very local scale, ignoring larger indels or inversions. In addition, if the polymorphism rate is very high in certain regions of the genome (~3% and up), haplotypes tend to be assembled into separate scaffolds. To examine these events, we recommend looking at the repeat structure).
Note: polymorphism tends to not be evenly distributed throughout the genome. There might be long homozygous stretches and clusters of SNPs and indels in other regions.


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Williams-Sonoma offers a large range of high-quality and reliable hand mixers designed to make recipe preparation a breeze. Immersion blenders and hand-held mixers are excellent for making soups, whipping cream or beating ingredients like eggs and flours. Use an immersion blender to prepare fresh baby food quickly and easily. Hand mixing and blending requires a good mixing bowl, and we have the highest-quality mixing bowl sets that are both freezer- and dishwasher-safe as well as very easy to clean. If you are baking a cake or preparing muffins or scones, our large selection of bakeware will have the perfect shape and size to finish the job.
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subset: commoncrawl


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AUSTIN (March 26, 2013)—Texas State Sen. John Whitmire, D-Houston, who chairs the Senate Criminal Justice Committee, says a prison informant has reported a death threat against him, but a prison official later said the threat was a scam.
Whitmire said authorities told him that the informant reported a "hit" against him because of complaints about the conditions on death row.
Whitmire said he's taking the threat seriously.
Whitmire said authorities are still tracking down leads on the case.
The threat comes one week after the Colorado corrections department chief was gunned down and the suspected gunman later died in a shootout in Texas.
Later Tuesday, Texas Department of Criminal Justice Inspector General Bruce Toney, the chief investigator for the Texas prison system, said the threat was a scam by an inmate who was hoping to gain some cash and reduced prison time.
Whitmire wasn't in danger, he said.
He said an inmate who in the past has provided some credible information to authorities "made up the story" about killing Whitmire and tried to enlist others to join him so they could get in trouble.
Instead, Toney says the inmate now faces possible new charges of lying to police and at least forfeiture of his existing "good time" credits that could have reduced his sentence.


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Our 16th action and our objective is the relief of the seabed from debris which ruining the environmental, and also to sensitize the residents and visitors about the marine enviroment !
Make a Donation Today!
Report your Dive Against Debris data here! LEARN MORE
Follow us on Instagram @projectaware
Copyright © 2013 Project AWARE Foundation. All rights reserved.


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I've just installed and configured my ps3 media server to stream spotify audio, which i cast locally via icecast+edcast; and it works like a charm. However, there is a noticeable delay between the audio on my laptop and on the ps3 and another laptop on the same network which uses winamp to directly listen to the cast. There's a 1-2 sec delay to the winamp laptop, and almost 10 secs delay to the ps3.
My questions is if there are any ways to tweak the buffering done or skip transcoding in the ps3 media server so as to decrease the delay? Or if this is a ps3 buffering issue which is hard to avoid?


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Book your room at Jurys Inn Glasgow
Get an overview of this hotelModern Scottish hotel in the heart of Glasgow
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Near Marsh UK
This modern hotel is situated in the heart of Glasgow; the Gallery of Modern Art is within 800 meters, and Hunterian Art Gallery is two miles away.
Hotel bar
Hotel guests can enjoy breakfast or dinner at Innfusion Restaurant, relax with a drink in the bar, or languish over a frothy drink in the on-site Italian coffee shop.
Satellite television
Jurys Inn Glasgow's 321 large guestrooms are equipped with satellite TV, free WiFi Internet access, direct-dial telephones and private bathrooms with complimentary toiletries.Would you like to give us feedback? Share it! Opens in a new window
Jurys Inn Glasgow80 Jamaica Street Glasgow Scotland G1 4QG
Hotel Amenities
Hotel Amenities
The Grill Bar at Jurys Inn Glasgow is open for breakfast, lunch, and dinner. For business travelers, this 3-star hotel offers a business center, free WiFi, and 10 meeting rooms.
The Jurys Inn Glasgow is a smoke-free hotel.
- Coffee shop or café
- Breakfast available (surcharge)
- Restaurant
- Business center
- Total number of rooms - 321
- Multilingual staff
- 24-hour front desk
- Laundry facilities
- Bar/lounge
- Elevator/lift
- Free WiFi
- Luggage storage
- Dry cleaning/laundry service
- Express check-in
- Meeting rooms 10
- Offsite parking discounted rates available
- Number of meeting rooms - 10
- Self parking (surcharge)
- Smoke-free property
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Self parking (surcharge), Offsite parking discounted rates available
Room Amenities
- In-room climate control (air conditioning)
- Air conditioning
- Coffee/tea maker
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Shower/tub combination
- Desk
- Satellite TV service
- Flat-panel TV
- Free WiFi
- In-room safe
- Room service (24 hours)
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible bathroom
- Roll-in shower
- In-room accessibility
Hotel Policies
Minimum check-in age is 18
Check-in time starts at 2 PM
Check-out time is noon
Payment types
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
No rollaway/extra beds available
No cribs (infant beds) available
Optional extras
- Fee for full breakfast: GBP 14.95 per person (approximately)
- Self parking fee: GBP 7 per day
Hotel Name
- Glasgow Jurys
- Glasgow Jurys Inn
- Jurys Glasgow
- Jurys Inn Glasgow
- Glasgow Jurys Hotel
- Jurys Hotel Glasgow
- Jurys Inn Glasgow Hotel Glasgow
- Jurys Inn Glasgow Scotland
Awards & Affiliations
National Rating
This establishment has received its official star rating from VisitScotland, the National Tourist Board for Scotland.


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The Atlantic: Stop Penalizing Boys for Not Being Able to Sit Still at School
This spring, as the grass greened up on the soccer fields and the New Hampshire air finally rose above freezing, the boys and I engaged in a pitched battle of wills over their intellectual and emotional engagement in my Latin and English classes, a battle we both lost in the end.
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STOCKTON - Two people were shot in separate incidents over an 11-hour span and treated at area hospitals for non-life-threatening injuries, the Stockton police reported.
In the first incident, a 20-year-old man told officers he was standing outside on the 500 block of East Oak Street about 5:30 p.m. Sunday when a suspect unknown to him walked up with a shotgun and shot him. He managed to get back to an apartment where officers found him.
In the second incident, a 24-year-old woman was walking on the 1100 block of North Madison Street at 4:08 a.m. Monday when she heard several gunshots. At least one of them struck her, but she could not provide any suspect information to responding officers.
STOCKTON - The countywide crackdown on drivers under the influence of alcohol or drugs continued Monday night.
Ten law enforcement agencies have combined their efforts since Dec. 14 to reduce the dangers on San Joaquin County highways and roads.
One hundred seventeen people had been arrested through Saturday. Last year, during the same 16-day period, the 10 agencies had made 124 DUI arrests.
There was one DUI-related fatality at this point in the 2011 campaign. There were no deaths during the same time frame this year.
The winter holiday campaign has been named Avoid the 10.
For New Year's Eve, a saturation checkpoint was scheduled in the Manteca area with the California Highway Patrol deploying all its available officers through midnight.
The DUI crackdown continues through today.
Location, ST | website.com


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SAN FRANCISCO -- The Detroit Tigers had five days off before starting the World Series, then played Wednesday's opener as if they could have used a sixth.
Ace Justin Verlander was clearly off, and the Tigers mustered little response to the magical night of the Giants' Pablo Sandoval in an 8-3 Game 1 loss at AT&T Park.
The issue for the Tigers is how they rebound after seeing Verlander, who brought a 0.74 postseason ERA into the game, serve up two of Sandoval's three home runs and leave after just four innings.
"It's very surprising, just because we're used to him being excellent every night," Detroit first baseman Prince Fielder said. "But that's why baseball isn't fun sometimes. You put your best player out there and he might not get it done. It happens. It's part of the game."
The Tigers, to a man, said the layoff from the time between their American League Championship Series sweep and the start of the World Series didn't have a negative effect.
"It's the World Series," Fielder said. "You could take a month off and your mind would get back into it. We just got beat."
Center fielder Austin Jackson said the Tigers will be ready to bounce back in Thursday's Game 2, as they send right-hander Doug Fister to the mound to oppose Giants lefty Madison Bumgarner.
"We do a pretty good job of putting games behind us and not getting too down about it," Jackson said.
But with the Giants not pitching their top starters, Ryan Vogelsong and Matt Cain, until Games 3 and 4, respectively, opportunity seemed to knock for the Tigers to take the quick upper hand.
Instead, they fell behind 6-0 after five innings and had no luck breaking through against the soft-tossing Barry Zito.
He held the Tigers to one run on six hits over 52/3 innings.
Perhaps just as important was that the Giants' Tim Lincecum relieved Zito and completely silenced Detroit hitters. He didn't allow a base runner over 21/3 innings and struck out five of the seven hitters he faced.
It's the type of dominant outing that Tigers hitters aren't likely to forget if they see the two—time Cy Young winner trot in from the bullpen again.
Jackson was facing Lincecum for the first time and was impressed.
"He's tough," Jackson said, "especially for guys that hadn't seen him before. He has nasty stuff, and you just gotta battle against a guy like that."
As if Detroit wasn't struggling enough, the Tigers had some quirkiness working against them, too.
Verlander had two outs in the bottom of the third when Angel Pagan's bouncer hit the third-base bag and shot into left field for a double that opened the gates to a three-run Giants rally.
Fielder was asked how damaging Pagan's wacky double was.
"Pablo's three homers might have hurt more," he cracked.


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2010 North Iowa Tour Finals
Saturday October 30, 2010
East Park DGC - Mason City, IA
• Must be a Qualified N.I.T. Member to get Invited
o Qualified Men – N.I.T. Member for a minimum of 3 Tournaments
o Qualified Women – N.I.T. Member for a minimum of 1 Tournament
• No Entry Fee!
• Everyone will receive a Custom N.I.T. Disc!
• Shelter House by Hole #1 Basket
• Player Check-In from 8:00 to 9:00 a.m.
• Player Meeting @ 9:15 a.m.
• 1st Round Tee Times start @ 9:30 a.m.
• Match Play (Head-To-Head)
• Players will be "Seeded" based on N.I.T. Standings
• Single Elimination Bracket
• Separate Men & Women Brackets
• Trophy for each Tour Finals Champion
8:00 a.m. to 9:00 a.m. Player Check-In
9:15 a.m. to 9:25 a.m. Player Meeting
9:30 a.m. to 10:30 a.m. Men's 1st Round
10:45 a.m. to 11:45 a.m. Men's 2nd Round & Women's 1st Round
12:15 p.m. to 1:15 p.m. "Second Chance" Doubles Tournament & Lunch Break for those who Tee off at 1:30 p.m. or later
1:30 p.m. to 2:30 p.m. Men's 3rd Round & Lunch Break for "Second Chance" Doubles Players
2:45 p.m. to 3:45 p.m. Men's 4th Round
4:00 p.m. to 5:00 p.m. Men's Champion ship Round & Women's Championship Round
5:10 p.m. to 5:25 p.m. "Mini" Putt Contest Finals
5:30 p.m. to 6:30 p.m. Awards Ceremony & Drawing
• Eliminated Players from Men's 1st & 2nd Rounds & Women's 1st Round
• Random Draw for Partners
• 1 Round of 9 Holes
• Best Shot
• Winning Team gets a Prize
• Everyone will be included in a Drawing to give away many Prizes
• Prizes will be awarded for the N.I.T. Standings
• Prizes will be awarded for the N.I.T. Bag Tag Challenge
• Spectators are welcome
"Mini" Putt Contest - $2 Entry Fee (Half goes to Prize for Winner, Half goes to 2011 N.I.T.)
Participants get 10 putts with a Mini, at a Mini Basket
Top 3 players with the most made putts, move on to the Final Round
Finalists only get 5 putts, most made out of 5 wins the contest
Sudden Death if a Tie occurs in the Final Round
Ace Fund Throw-off - $2 Entry Fee (Half gets added to Ace Fund, Half goes to 2011 N.I.T.)
Entire Ace Fund that is left over after the tournament in Belmond
Participants get two throws at a Basket from about 75-100 feet away
Ace Fund will be split between all made shots
If no made shots, the shot closest to the basket gets all the money
N.I.T. Custom Disc Sales - $10 Each
Any remaining Custom N.I.T. Discs will be sold as a fundraiser for the 2011 North Iowa Tour, will the proceeds going to that.
• If you would like to donate money to the 2011 N.I.T. please visit with Mark Skellenger.
• If you get knocked out early, you are more than welcome to follow a group around the course or to caddy for your favorite player still left in the competition, be sure to cheer on and encourage any remaining players!
• The Mini Putt Contest and Ace Fund Throw-off will be available all day long, as long as a Tour Staff Member is there to witness your participation and collect Entry Fees.
• Be sure to pay attention to the Tee-Times for each round as they may change, all Tee Times will be displayed on a board at the Shelter House (Tournament Central). We want to keep each round moving as quickly as possible since we are also battling the Sun Light as well as our competitors!
• Every Round will be a "Staggered Start" at the Tour Finals, meaning all Groups will Tee Off on Hole 1 every 5 minutes from the start of the round
• Each Group will consist of 4 or 6 people (2 or 3 matches)
• You will be competing "Head-to-Head" against one other player
• Each Hole is worth 1 point
• The Player who finishes the hole with fewer strokes wins the point
• If both players shoot the same strokes on a hole and tie, each will get ½ point
• The Player who finishes the hole with the most strokes gets 0 points
• The Match is over once one person reaches 5 points, so you do not have to complete any remaining holes, save your energy, and it will also help us keep things moving quickly
• If there is a tie at 4.5 points after 9 holes, start back at hole 1 playing sudden death, the first person to win a hole wins the match
• The person who has a lower seed number tees off first on the first hole (#1 would tee off first when playing against #5)
• The Tee order does not change if both players tie the previous hole
• The person who wins the previous hole tees off first on the following hole
• The person who is farthest away from the basket throws their next shot first
See you all there!


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RICHMOND -- Kory Judd has no illusions about taking the helm of a massive, aging oil refinery besieged by critics and government investigators after last year's crippling fire.
He uses the word "daunting" to describe the task that awaits him as general manager of Chevron's Richmond refinery, the first such role he has held in his 27 years with the oil giant. But the chemical engineer has always loved fixing things, and there's plenty on the to-do list in Richmond: implementing new safety and maintenance safeguards to prevent a repeat of the Aug. 6 blaze that shut down one of the West Coast's key crude units for months and spurred 15,000 people to seek medical treatment; restarting a long-sought refinery modernization project that stalled in court four years ago; and nurturing the refinery's complicated, and often-polarizing, relationship with the Richmond community, which was further frayed by the fire.
"I'm from a world where you worked with your hands; you fixed things," Judd said, hearkening to his childhood in the tiny coal-mining town of Price, Utah. "If you're a chemical engineer and you have spent that time honing your skills, there is really nothing better than a refinery. It blends the different disciplines together. It's a good place to go if you like the hobby."
Hired by Chevron in 1986 after graduating from the University of Utah, Judd, 53, has spent nearly three decades mastering the intricacies of the firm's refinery operations across the nation. He lacks the MBA credentials of his immediate predecessors and is more at ease within the world of advanced metallurgy than the glare of local politics, where the refinery's actions are always a source of spirited debate.
But Judd will need more than technical expertise to navigate the myriad challenges that await him in Richmond, where he started his career. It would have been daunting enough even before the Aug. 6 fire that resulted in intense scrutiny -- and criticism -- from investigators with the U.S. Chemical Safety Board and the state Division of Occupational Safety and Health (Cal/OSHA), which issued a record fine.
"You can't deny the fact that it brings tremendous complexity," Judd said of the investigations. "Multiple outside agencies have been here, taking a thorough look ... and we have probably seen as much scrutiny internal as external. The challenges are great, but so are the opportunities to improve."
When Chevron announced June 5 its replacement for General Manager Nigel Hearne, Judd was something of a mystery, having worked largely out of the public spotlight during a Chevron career that has included seven site transfers. He plans to lean heavily on those around him as he adjusts to his new role.
"The fortunate thing is I am not on an island," Judd said. "There is an operations manager (Matt Brown) with all the experience I have, and in the community I have (staff members) who are excellent. But I try to bring perspectives, to set the boundaries."
Critics have portrayed the refinery general manager as little more than a puppet dancing on the strings of corporate decision makers. Judd brushes those notions aside. "There is a lot of deference paid to refinery general manager," Judd said. "It's a role of leadership and responsibility; my bosses listen very closely to a refinery GM."
During a wide-ranging interview last week in the general manager's office that is not yet his -- pictures of Hearne's children still adorn the desk -- Judd reflected on the challenges, responsibilities and power that come with his new job.
"Modernization of our refinery," Judd said when asked to lay out his priorities. "Our sights are set on a big project that we think makes a lot of sense, lowers our emissions, uses new technology and invests a lot of money and creates a lot of jobs in the community."
Chevron first proposed modernizing the century-old refinery in 2005, but a legal battle with environmentalists ensued and the project was halted by a state court in 2009. A revised application is before the city.
Judd quickly added that he wants to increase the amount of volunteering by Chevron's more than 2,000 employees and contractors in Richmond, a goal also declared by Hearne, and to increase local hiring of Richmond residents by 50 percent over the next five years.
But Judd doesn't duck the criticism from the fire. Both the Chemical Safety Board and Cal/OSHA determined the refinery was guilty of a slew of safety violations that included failing to replace the corroded pipe responsible for the fire. And Judd puts a positive spin on any tension that has existed between the company and investigating agencies, saying it results in "thoughtful discussion."
"The Chemical Safety Board came in and took a hard look, and we are going to make our business better."
While he's eager for the refinery and its workers to play a visible role in the broader community, Judd wants the plant itself to operate with a low profile.
"The only way to make (the anger from the fire) go away is to be a responsible, quiet, out-of-sight operator for a period to earn that respect. ... We have greatly retooled our inspection processes and are changing the way we look at damage mechanisms. We look at how things rust, how things get old."
Judd also suggests he will be around for a while, which would be a departure from the relatively short tenures of recent general managers, including Hearne, who lasted fewer than two years.
"It's hard to imagine that in, say, two years I would be ready to do something different," he said.
How he will fare atop a 245,000-barrel-a-day refinery in a town increasingly hostile to its presence remains to be seen. Councilman Nat Bates, a staunch Chevron supporter, said he had a long meeting with Judd and praised him as "sincere and capable."
Jim McMillan, a councilman in the 1980s and '90s, said that in his day relations between the city and the refinery were buoyed by personable general managers. He said Judd's non-MBA pedigree may be a good thing.
"The refinery management is much more corporate now than in the past, and the general manager gets shifted in and out from wherever and has little relation to the community," McMillan said. "The guys who ran it before may have been tough and gruff, but that was OK, this is a tough town."
Contact Robert Rogers at 510-262-2726 or email@example.com. Follow him at Twitter.com/roberthorgers.
Title: General manager of Chevron's Richmond refinery
Age: 53
Family: Married, five children
Experience: 27 years with Chevron
Education: Bachelor's degree in chemical engineering, University of Utah
Quote: "The industry and community have become much more sensitive to incidents, and rightly so. Zero (incidents) is attainable."


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If they build stuff, students will come -- to learn more.
That's the idea behind a recently opened fab lab at Castilleja School in Palo Alto. Thursday afternoon in Elaine Middleman's Biology and Economics of Cancer class, seniors Suzie Quackenbush and Christine Herrmann, both 18, were working on what they called a cancer-screening box, a device that would allow researchers to view slides with cells. After three days working at the lab, they had a cardboard prototype held together with blue tape.
"Eventually it will be made of thin wood, with metal hinges," Quackenbush said. "It'll look much better than this." It will have to work, too. Middleman said the students are being graded on "producing a functional product."
Distance learning, YouTube, the iPad -- new technology is helping transform education in many ways. But the Bourn Lab, a fabrication lab built especially for middle- and high-schoolers, aims to get students to create tangible things.
The Bourn Lab is part of the FabLab@School program, which was created by Paulo Blikstein, an assistant professor at Stanford who has a similar lab on campus and who started one in Moscow. Blikstein was a master's student at Massachusetts Institute of Technology around the time a fab lab was created there, he said.
Exploring vs. lecturing
Other fab labs were born out of that MIT effort. The Fab Lab San Diego, for example, has programs for adults as well as school-age students, said its director, Katie Rast.
But when Blikstein came to Stanford, he wanted to bring a lab to school kids. Blikstein, an engineer with a Ph.D. in education, wants to re-create the role of labs in schools, which he says have become "places where invention and creativity go to die" because typical science experiments require students to do not much more than follow directions. His goal is less lecturing, more exploration.
The Bourn Lab has a couple of 3-D printers, a 3-D scanner, a laser-cut printer and other equipment that have enabled one seventh-grade history class, for example, to re-create models of Leonardo da Vinci's machines. A revolving bridge, an aerial screw, a catapult and other laser-cut wood models of the great inventor's machines now sit in Castilleja's library for all to admire.
"There's a lot of engineering in history," Blikstein said. "The lab allows history, engineering, math to be taught in an integrated way."
After seeing some of the impressive work the students did with the Leonardo project, one parent asked how much physics the girls learned, said Nanci Kauffman, the head of Castilleja, a private school for sixth- through 12th-grade girls.
"My thing was, 'How much more did they learn about da Vinci?' " than if they had simply heard lectures from their history teacher or read a book, she said.
Parent volunteer Diego Fonstad pointed out plastic figures made by students in a 9th-grade geometry class. "The girls went out of control, way beyond what we expected," he said, pointing to a 3D-printed model of R2-D2 and other figures. "All designed mathematically," he adds.
Kauffman said she's hoping the lab, which had its ribbon-cutting in March, fosters a risk-taking culture at the school. "Girls and women struggle with that," she says. "Here they can be willing to get behind a half-baked idea and try."
Hands-on high tech
Fifteen out of the 60 teachers at Castilleja -- representing every department -- have been through a lab training headed by Blikstein, and more teachers will take part. In addition to training and regularly meeting with the teachers, Blikstein is heading a team of about 20 people at Stanford to study how well the FabLab@School concept works. "Research is the best way to ensure it's going to continue," he said.
The equipment for the lab cost about $60,000 and was funded by the school, the Edward E. Ford Foundation and the Doug Bourn memorial fund. Bourn, an engineer at Tesla Motors (TSLA), died in a plane crash in East Palo Alto in 2010 along with two other Tesla employees. Bourn was Castilleja's robotics mentor.
As part of its partnership with Blikstein, Castilleja also is helping with the cost of another school fab lab, at East Palo Alto Academy, which will open later this year. Blikstein said he's currently talking with teachers at both schools -- he has worked with teachers at East Palo Alto Academy for a while, and some of the school's students have been using his Stanford fab lab regularly -- and envisions having students from the school in East Palo Alto do joint projects with Castilleja students.
"We want to democratize by expanding to public schools," Blikstein said. "Society pays attention to high-tech tools. Putting them in the hands of kids" who otherwise might not be exposed to them, he said, "that's very valuable."
It's a sentiment echoed by Betsy Corcoran, CEO of Burlingame startup EdSurge, which aims to provide information about technology in education. EdSurge is helping shine a spotlight on the learning-by-doing movement at next weekend's Maker Faire in San Mateo -- where the Bourn Lab will have a presence.
"What's most compelling and exciting to us -- and teachers and students -- is when students learn by building," Corcoran said.


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Well, that didn't take long. Andrea and the Governor have barely gotten to know each other and they're already finding time for a little nookie. Yes, tonight they engaged in some hot, steamy sex.
Apparently, all of the Gov's passionate talk of life, liberty and the pursuit of walker-free happiness held a seductive sway over Andrea. As for the brutal, bloody action at the Woodbury octagon? It didn't repulse her as much as she initially indicated. In fact, it was kind of a turn-on.
But we're getting ahead of ourselves. Season 3's sixth episode, "Hounded," was notable for things other than the Woodbury Quickie. In fact, it featured crucial action on several fronts, including the prison, where we follow up on Rick's mysterious phone call and learn the fate of Carol; and in the woods, where Merle gets a first-hand lesson in just how tough and lethal Michonne can be; and in town, where Merle has a violent reunion with two members of our survivor party.
First, let's head to the woods: Merle is leading three other men on a hunting expedition for Michonne, when they make a grisly discovery. The severed limbs -- and the trunk -- of zombies have been placed on the ground to spell out "Go Back." Merle, of course, knows he's looking at the handiwork of Michonne.
"It's a biter-gram!" he says, trying to inject some levity into this scary trek.
Of course, they're not going back. After all, they're four mighty manly men with guns. And she's just one little chick with a sword. What's there to be afraid of?
Big mistake. Faster than you can say "Merle's a red neck idiot," Michonne swoops out from the trees to swiftly behead one of the men and fatally stab another. But a Merle does manage to get a shot off and Michonne is forced to scamper away with a bullet in her leg.
"Are we having fun yet?" a ticked-off Merle shouts.
Meanwhile, back at the prison, Rick, still in a stupefied state, is talking on the phone. It turns out that a woman is on the other end, speaking of how she and others have found refuge in a safe place "away from them." Rick pleads with her to reveal the locale and to take in his beleaguered band of survivors in. But she's hesitant. "I'll call you back in two hours," she says, and hangs up. Rick is sorely disappointed.
When the phone does ring later, a man is on the other end and he's asking some uncomfortable questions. Are you dangerous? Have you killed anyone? How'd you lose your wife?
The last one, of course, is a stunner.
"How do you know I had a wife?" Rick replies, before saying, "I don't want to talk about that."
Cut to: Woodbury, where Andrea has been given permission by the Governor to work the wall with another woman. But her first -- and last -- day on the job doesn't go well. Andrea's trainer is an Olympic-caliber archer whose dad taught her how to shoot. And when a walker approaches the wall, she expertly plants two arrows in him.
But the walker stubbornly refuses to go down, so Andrea jumps off the wall, pulls a knife and embeds it in the walker's eye. A look of orgasmic satisfaction comes over Andrea's face.
"That's how you do it!" she exclaims.
But her trainer is livid. Woodbury rules state that you NEVER go over the wall. "This isn't a game!" she snarls.
Meanwhile, back in the forest, it's Round 2 of Michonne vs. the guys. Michonne first sticks Merle's partner and then engages in hand-to-hand combat with Merle, But the fight is interrupted when a clot of walkers emerges. Michonne again scrambles away.
By now, Merle has had enough. He realizes that this super-warrior woman is more than he can handle. So he hatches a plan: They'll return to Woodbury and tell the Governor that they killed her. She's as good as dead anyway, he reasons, because she's headed toward the red zone.
But in a startling character change that makes no sense to Merle (or us), the man refuses to back down. Only moments earlier, this guy (named Garjulio, or something like that), was practically peeing his pants during the hunt and Merle had to order him to man up. Now, suddenly, Garjulio (Merle calls him Neil), after seeing two of his friends taken out by the female killing machine, wants to go after her?
Merle will have none of it, so he does the only thing left to do: Shoot him in the head.
Merle then continues on alone and his path eventually leads him into the abandoned town, where -- wouldn't you know it? -- he happens to come upon Maggie and Glenn, who are on a run for provisions. This of course, is not the happiest of reunions. Merle asks if his brother Daryl is still alive. They tell him yes and Merle demands that they take him to him.
Not wanting to reveal their locale, Glenn makes a counter-offer.
"No, we'll bring him here."
Of course, this angers Merle, who takes Maggie hostage and forces her into a car.
Meanwhile, back in Woodbury, there is love in the air. Andrea, after being briefly chastised for her actions on the wall, has admitted to the Governor that she actually liked the town fights. Oh, kinky. The governor pops open some whiskey and begins to talk about the good things in life. It's like cat nip to Andrea, who has experienced too many of life's horrors. They lock lips and eventually wind up in bed ... only to have their time together cut short by a knock on the door.
It's Merle.
Our blade-fisted red neck lies through his teeth, telling the Gov that he managed to kill Michonne, but the other three guys in the hunting party met their doom. The Governor, like the wicked queen in "Snow White," wants a trophy for proof.
Did you get a head ... or her sword? he wonders.
No, Merle replies. They were caught in a walker attack and he had to flee. But "I've got something else for you," alluding to Maggie.
Back at the prison, Rick has gotten another phone call. This time, it's a woman again. "How do you know me," he asks ... and then slowly, gradually, we realize that the voice on the other end belongs to ... LORI!
Rick is in anguish mode now -- the kind of scene that actor Andrew Lincoln absolutely excels with. He's tearing up. Filled with remorse and regret. (And, of course, hallucinating).
"I loved you," he says, his voice cracking ... "I couldn't put it back together" ... "I should have said it." ...
The voice on the other end is reassuring. He has a son and a new baby to take care of. He must move on. This is the closure Rick needs. Apparently ready to take back his role as noble leader, he hangs up the phone, returns to his group of survivors and, yes, holds his baby for the very first time.
That alone would have provided a satisfactory ending to the episode, but we've got two more twists: While Rick had been in the boiler room playing phone tag, Daryl has been roaming the prison in an attempt to clear it of walkers. He came upon a fallen walker with a knife planted in his neck and immediately recognized it as belonging to Carol. After a little exploring, he finds our AWOL survivor holed up in a little room ... still ALIVE.
The episode then winds down with a scene that has Rick strolling out into the prison yard, where he sees a woman, surrounded by a small group of walkers, poised at the fence.
It's Michonne. ... (Fade to credits)
So there you have it. Episode 6 -- various factions coming together as we figured it would. What did you think of "Hounded," and where do you think we're headed from here?


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Report: 700,000 in NC could get insurance tax breaks
Published: Tuesday, November 5, 2013 at 7:26 a.m.
Last Modified: Tuesday, November 5, 2013 at 7:26 a.m.
RALEIGH (AP) — A new analysis estimates that nearly 700,000 North Carolina residents will be eligible for tax breaks that cut the cost of buying private health insurance on the new marketplaces run by the federal government.
The nonpartisan Kaiser Family Foundation says in a report released Tuesday that North Carolina will be near the top of states with the most low- and middle-income people benefiting from the subsidies.
Residents who qualify for tax credits generally must have income between the federal poverty level and $94,200 annually for a family of four. They can't be eligible for affordable coverage from an employer or from Medicaid or Medicare.
The health policy group says two million people in Texas and almost that many in California would be eligible for tax credits.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Dennis D. Gaskin, DDS, P.C.
Dennis D. Gaskin, DDS, FICOI, FAAIP
Sladjana Skrba, DDS
(757) 463-5105
3980 Virginia Beach Blvd., Loehmann's Plaza, Suite 103, Virginia Beach, VA 23452
Get Directions View Map 36.841594,-76.112139,Virginia Beach,3980 Virginia Beach Blvd.,Loehmann's Plaza, Suite 103,Virginia Beach,VA,23452
The practice opens at 7:00 a.m. Monday through Friday to serve you.
Dennis D. Gaskin, DDS, FICOI, FAAIP, is a general dentist and practice owner of this Affordable Dentures & Crowns location, which opened in 2012. He and his staff look forward to fulfilling the denture needs of patients who travel from Chesapeake, Middleton, Norfolk, Hampton, Chesapeake Beach and surrounding communities.
Dr. Gaskin earned his Doctor of Dental Surgery degree at University of North Carolina School of Dentistry. Based on many years of valuable dental experience, he and his staff are proud to offer professional, compassionate care to patients that visit this practice.
Dr. Gaskin's dental center has an on-site dental lab that fabricates new dentures and provides repairs and relines, often with same-day service. Being able to provide dentures in a day is a significant advantage, especially for patients who have traveled far distances to visit the practice. The on-site lab also eliminates the need to use outside commercial labs, which helps keep our fees low.
Our highly skilled lab technicians have crafted thousands of dentures. Their training and experience are assets to Dr. Gaskin's practice and give you the confidence that your denture is being fabricated locally in Virginia.
This practice offers the following services:
Payment, Insurance & Financing Information
Method of Payment
Payment for service is required after you see the dentist and a treatment plan is approved based on your clinical needs. This practice accepts: Cash, Check with valid ID, Mastercard, Visa, American Express, Discover.
Financing is available through CareCreditSM, a Synchrony Bank company.* To pre-qualify for credit, click on the link below and complete their on-line application form. CareCredit's approval response is provided quickly.
Some practices require a minimum treatment fee to use this service. Please contact the practice you would like to visit for more information regarding their specific CareCredit policies.
*Subject to credit approval. Minimum monthly payments required.
Click here to apply for Care Credit.
Insurance Information
If you have dental insurance through a carrier not accepted at this practice, an appropriate dental walk out statement will be provided so you can file your claim directly with your insurance carrier.
Be assured you will save money by filing the claim yourself. Affordable Dentures fees are so low, the total cost for the services you will receive at this location are likely less than the co-pay you will be required to pay at most other general dentistry practices. The practice staff can help you calculate the costs so you can make the best decision.


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We're nearly midway through 2010, and we'd like to take this opportunity to share
the progress made by the Dr. Jane's HealthyPetNet Foundation thus far into 2010.
While we have highlighted some of the caring animal rescue agencies who have received
financial awards this year, many more grants have been awarded.
Before we convey some of the details about these worthy organizations, we want
to thank you for all that you've done to support our foundation. Even if you have
never made a donation directly to the Dr. Jane's HealthyPetNet Foundation, if you
have ever purchased any of our products, you have contributed to its reserves and
thus helped animals in need. And for that, we thank you from the bottom of our hearts.
As you've probably noted, the vast majority of the animal rescue groups selected
for our grants are small non-profits who typically operate on shoestring budgets.
In many cases, the only assets these heart-full groups have are the people dedicated
to aiding homeless and abused companion animals. Frequently located in small communities,
these affiliations fulfill a vital need in under-served areas of the U.S. Not only
do they accomplish so much with so few resources, they work every day to relieve
suffering and enrich their communities. More...
a veterinarian, I am commonly asked "Why do cats purr?" Most people believe cats
purr when they are content or happy. While cats do purr when they are content,
researchers attempting to uncover the answer to this 3,000-year-old mystery are
finding the answer more complicated than previously thought. All domestic cats
purr, as well as many wild cats, like pumas, ocelots, lions and cheetahs.
Purring can occur in a variety of situations. When cats purr in the presence of
other unknown cats or kittens, the behavior may serve to convey submissiveness
or a friendly greeting. While it is true that cats purr contentedly while on
their pet parent's lap, they also purr when they give birth, when they are
frightened, severely injured and even while dying. Because kitties clearly
cannot be content in all these situations, contentment or friendliness cannot be
the only reason they purr.
So why else would they purr? More...
Nail trimming is a vital part of your pet's healthcare routine. Unfortunately,
it's often neglected as many pet parents never receive any training about the
best method for trimming nails safely. Watch this short video for helpful tips
for better nail care. More...


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Holocaust Denial on Trial, Trial Judgment: Electronic Edition, by Charles GrayTable of Contents
|<< Case for the Defendants
|< Introduction
Irving's response
5.243Irving did not accept that Judge Biddle's note was referring merely to the passage which I summarised above. He asserted in his closing submission that, when cross-examining her, defence counsel had suggested that she had not even been in Auschwitz. This was not a proposition which Irving put to Evans in cross-examination (and he directed no questions on this topic to van Pelt). Irving argued that Mme Vaillant-Couturier had made some absurd claims in her testimony (for example that there was a man-beating machine at the camp). Irving persisted in his claim that, from what he had read of the Judge's private papers on the testimony given by the various witnesses, he was able to assert that Judge Biddle was making a general comment on her evidence. Irving did not produce whatever papers he was basing this claim upon.
5.244In his evidence he asserted that Judge Biddle "became so fed up with this woman's testimony that he can finally stand it no longer and he dictates in parenthesis into his report - he says 'this I doubt'". But he did agree that what he had said at the launch of the Leuchter report was a "gloss" on the Judge's comment. He excused it by saying, incorrectly, that it was years since he had read the judge's notes. By way of explanation for the fact that he had quoted the Judge as saying 'All this I doubt" when he spoke in Toronto, Irving claimed, firstly, that he added the word 'all' to make it more literate for his audience and later that the Judge had altered the words "This I doubt" to "All this I doubt". He produced no evidence for the latter claim.


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How To Buy Binoculars
Binoculars can be used for a host of outdoor and indoor activities, from bird watching to football games, to concerts. No matter what activity you use them for they will always serve the same purpose: to improve your view of a distant subject. However, how you plan to use your binoculars, and where and when, are critical to the binocular selection process.
How to buy binoculars
The pair of binoculars you buy will probably end up lasting you a lifetime. Therefore, it is important to take a look at all the different features in order to determine which features are really important to you.
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text:
News 12 at 6 o'clock / Friday, Sept. 21, 2012
BLACKVILLE, S.C. -- Texting and driving can lead to the wreckage in front of Jefferson Davis Academy in Blackville this week.
"This was a normal car that was driving down the road, and a split-second decision caused him his life," said Amy Boney, a health teacher at the Jefferson Davis Academy.
The car wound up wrapped around a tree, and the Barnwell County driver was dead. He or she was just one of the 570 South Carolina traffic fatalities so far this year.
"I thought it'd be about half of that really. That's a lot of people," said JDA student Will Gee.
"The reality is most of our children probably do text and drive. Most adults admit to texting and driving, so I'm pretty sure my children do, too. They think it's not going to happen to them," said Boney, who set up the week of presentations to educate the students on the dangers of texting and driving.
On Thursday, she invited the South Carolina Highway Patrol and the Alcohol Enforcement Team of the Second Judicial Circuit to her Blackville school.
Lance Cpl. Judd Jones of Highway Patrol explained how dangerous distractions can be with road conditions changing every second.
"I've seen people reading the newspaper, maps, women doing their hair and makeup. I saw a guy brushing his teeth one time," Jones said.
He says cellphones are the biggest distraction for teens, and traffic crashes are the number one killer of teenagers. Out of the 570 fatalities so far this year in South Carolina, 101 were teenagers behind the wheel.
"They actually make up a small percentage of drivers on the roadway but a large number of fatalities that we have on the roadway," Jones said.
Even though South Carolina doesn't have a law banning texting and driving, Jones told the students there are other things they can be charged with if they hit and possibly kill someone while texting and driving.
Jones and Steve Deibel from the AET also preached the importance of wearing seat belts. About half of the students at JDA raised their hands to admit they don't wear one unless they see a cop.
Gee says he thinks the presentation on Thursday may have changed some of his colleagues' minds. Jones and Deibel say hopefully the presentation saved some lives, too.


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Lucas wanted David Lynch to direct Return of the Jedi Dec 11 2009
In this video, Lynch decribes a visit with George Lucas and why he turned down Lucas' offer to direct Return of the Jedi.
So, he took me upstairs and he showed me these things called Wookiees. And now this headache is getting stronger.


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Jindal appoints three locals to state boards
Published: Friday, March 1, 2013 at 5:06 p.m.
Last Modified: Friday, March 1, 2013 at 5:26 p.m.
Gov. Bobby Jindal has appointed three local residents to state advisory boards, his office said Friday.
Lafourche Parish President Charlotte Randolph and Houma real estate agent Bill Boyd were reappointed to a board looking for ways to complete Interstate 49 from Lafayette to New Orleans. They are among 23 members of the Interstate 49 South Feasibility and Funding Task Force.
Dr. Rachael Marchand, a Houma dentist, will represent the Houma-Thibodaux area on the 14-member Flouridation Advisory Board. It works with local water systems on issues dealing with flouride and the drinking water supply. Flourde has been found to strengthen teeth and fight cavities.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
WAYNESBORO — A woman told Waynesboro police a man got out of his vehicle, walked through her yard and returned to his vehicle at 10:21 p.m. April 12 in the 200 block of Mount Airy Avenue. The area was checked, but the man was not found.
Location, ST | website.com


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Every song is juiced with something special; the boys are in their best 'Phish 3.0' form right now, no question. The Curtain (With) jam - which (Attention, Nerds!) is basically a Reba jam in Limb*Limb's meter, with all the roiling tension and tonal-shifting that implies - is customarily beautiful; the reggae tunes are groovy; Song I Heard... is pure rock'n'roll climax; Mike's and Ghost are on par with their best renditions of the year (Mike's Song is particularly encouraging).
But the best moments - the patient, multifaceted Light jam and the stunning Ghost > Mango > Weekapaug > Llama sequence - are as good as anything since summer 2003. Light is more insistently rhythmic than the celestial 8/7 Greek version, but just as rich, and few moments in Phish's recent history can compare to the feeling of ecstatic release shared by band and audience alike during the show-ending string of segues, with Trey belting out off-key lyrical callbacks and careening madly from one improvised transition to the next. It's old-fashioned fun in a distinctly new musical language: they've finally figured out a way to integrate the spare/spacy sound of their late-90's music, and the rock-hedonist haze of their '2.0' material, with their recent song-driven approach (itself a much more emotionally accessible throwback to their contained early-90's performance style).
What's missing is the ominous darkness that coloured Phish's greatest performances - the joyful peaks of those classic Fall '97 shows were all the more extraordinary for the forbidding valleys that preceded them. Not to say Phish 2010 are always cheery, but they're certainly a lot less inclined to give in to darkness and melancholy than they once were. For instance, compare this ASIHTOS to the canonical 6/19/04 version, which spends half of its 18 minutes in deep cold water before alighting on an icy shore. The much busier Amherst version resolves in a mighty wail from Trey's guitar, and if 'resolve' is a very fine emotion for a musician to share, it doesn't stay with you, haunting your sleep, like the distance and loneliness contained in the SPAC version.
Yet I wouldn't wish on my worst enemy the heartbreak and inner torment that produced Phish's pre-retirement music. The new happier Phish might not have any interest in the dreadful vistas opened up by their years of Weary Continuance - or maybe their interest is outweighed by sensible self-preservation - but after all, they're just four middle-aged guys. And we share in their happiness. And we've got the tapes. Those were scary years: the millennium clock counting down, resources dwindling, cliff edges growing nearer seemingly on all sides, deathly voices of unremembered times welling up from below, the boneyard of the past...
I wish to go back, sometimes, but also, certainly, to return afterward. Always remember that 'Go toward the light' is not an invitation to more life - and neither is 'Come into the dark.' That was the serpent's-voice of Chance calling out, but we (with this quartet of artists we love) content ourselves instead with Change, which is inexhaustible. And who'd begrudge his fellow human being's contentment, anyhow? Isn't that one of the things we came for?
You should seek out this show, along with (unquestionably) 10/19 through 10/23, 10/12, and (you have the hard drive space after all) the whole rest of the tour when you get a chance. That's a simple answer to the hard question, I guess.


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Product Description
The Backpack from Picnic Time's Mode Collection features napped polyester felt with padded backpack straps. "Seat belt" webbing accents on the front of the straps provide grip points for adjusting the pack's load or to secure utility clips or the like. It has a padded laptop compartment at the back of the pack's exterior with secured zipper-access. A drawstring opening for the main compartment is hidden under a front flap that has a zippered pocket and closure tab. An exterior beverage pocket on the side of the pack provides quick and easy access when you're in need of hydration. The Backpack - Mode Collection makes a thoughtful gift for students or others who enjoy an active lifestyle.


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By the mid 1940s, there was a clear trend for heavy-duty trucks to have diesel engines. This was something fairly new to Volvo, which had been concentrating on Hesselman engines due to the lower development costs needed for the Hesselman engine compared with the diesel engine.
The first heavy-duty diesel truck - on demand
Today, it is perhaps necessary to stress the fact that the number of heavy-duty Volvo trucks made up to and including 1945 was rather small, the majority of Volvo trucks being light-duty and medium-duty trucks, which were made at a good profit (which helped to finance the future-oriented car production of Volvo, which was unprofitable until the early 1950s).
The L29 range of trucks was extremely rugged and powerful, but was made in rather small numbers. It was natural to take this range as a base when the first powerful heavy-duty diesel truck was introduced in 1946, initially very much in response to demands from the National Swedish Road Administration, which needed a very powerful vehicle that could carry out snow-ploughing in the heavy Swedish winter as well as being a basic vehicle for construction of roads (the post-war era was a period when there was a great deal of renewal of the road network in Sweden).
Built on simplicity and efficiency
The design of the L29C/V vehicles (C=Civilian, V=' Road Administration vehicle', i.e. truck for use by the Road Administration) was simple and efficient. The existing L29 heavy-duty trucks were improved, reinforced and acquired an even longer bonnet to house the big powerful Volvo diesel engine, which was initially of the pre-combustion type (but in the later part of the production period of this series of trucks, it was replaced by the modern 'VDF' direct-injection engine).
The LV29 C/V, which was really a successful compromise, was superseded by the modern-looking L39 Titan in 1951, and was to a great extent based on the L29 C/V components - at least during the first years.
In the absence of power steering, driving a L29 C/V was tough work, and in those days a truck driver really had to possess brutal physical strength.


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"If the regulatory submission is for a known process or expression system, the regulatory agencies can review it quickly," says Jim Bingham, PhD, senior director of Development at Amplimmune, Inc. (Rockville, MD). "If it's for a novel technology with no history, such as an untested expression system, it may require a significant evaluation to manage risk and safety. Coming into it, [the regulators'] perception of the innovators can be, 'These guys are cowboys.'"
Indeed, the first companies pioneering adoption of a new manufacturing technology will almost certainly deal with some delays in approvals by the FDA, the EMEA, and others.3 Even if the product produced in a new system may be better (e.g., by having greater consistency, purity, potency, or safety), caution on the part of regulators about new developments is a necessary part of the regulatory system. At the moment, there are insufficient precedents to enable calculation of likely approval delays caused by adopting new manufacturing technologies.Thus, pioneering the regulatory approval of a biological product manufactured using a novel expression system can be daunting, even for the most experienced regulatory manager.1 Many in the industry feel that the regulatory challenges involved do not warrant the benefits of modifying old manufacturing processes. After all, the standard expression systems, E. coli, Chinese hamster ovary (CHO) cells, and Saccharomyces cerevisiae, which are used for about 90% of currently marketed recombinant protein and monoclonal antibody products, perform adequately. So why change?2
This thinking leads to a logical pack instinct, in which companies wait for a critical mass before adopting new technologies for commercial production. But if no one is willing to take the risk, that critical mass will never be reached. This catch 22 faces those who consider adopting almost any new biopharmaceutical manufacturing technology. As a result of such concerns, many new expression systems now commonly used in research have yet to make it to large-scale manufacture.
Nonetheless, no high-tech industry can afford to ignore new and better technologies, and biotech is no exception. There are hundreds of new and long-ignored expression systems using novel host organisms and technologies in various states of development and industry adoption.1 These platforms can offer many advantages, such as lower costs, higher yields, quicker turnaround or continuous manufacture, increased simplicity of expression and purification, less expensive equipment and infrastructure, and simpler and more rapid scale-up.1
Because of these advantages, a few companies are finding the organizational fortitude to be regulatory trailblazers. For example, the first product manufactured using transgenic animals, recombinant human antithrombin (Atryn, from GTC Biotherapeutics) received FDA approval in early 2009; and a recombinant human papillomavirus (HPV) vaccine expressed in insect cells using baculovirus vectors (Cervarix, from GlaxoSmithKline), is pending at the FDA and already approved in the European Union. Many other recombinant proteins using novel expression systems are in development, mostly at early stages. This includes products being developed by expression systems' developers and their partners who intend to prove commercial feasibility of their technologies through actual product manufacture.
In addition, many contract manufacturing organizations (CMOs) are starting to adopt and offer new expression technologies, at least in early-stage R&D. This will likely expand as products progress in development pipelines and their manufacture is further scaled-up.
Many of the products expected to enter the market using new expression systems are biosimilars and follow-on proteins. Biosimilar developers are motivated by manufacturing costs, so they may be a little more willing to adopt state-of-the-art technologies, which often make production cheaper and faster. In addition, new expression technologies may make it possible to produce drugs that are of higher quality than the innovator products. Many of these biosimilars companies want to be able to claim that their products are not just cheaper, but also better—more consistent, purer, more potent—than their reference products.


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Make sure your young player is ready for any Chicago Bears game with this Youth Chicago Bears # 6 Jay Cutler 1940s Throwback Jersey. Boasting bold contrast color detailing with team graphics and your favorite player's number 6 printed on the front and back, it's guaranteed to give a young fan bona fide Bears style without bulk, so you can stay undoubtedly true to your team all day, every day—especially on game day!
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Built for all times.
Strong just like always.
Even today, the Great Recession lingers as a vivid and sobering reminder of what can happen when those responsible for managing others' finances fall away from prudent practices.
Unchecked, risky, and/or unethical behavior usually reveals itself, and the consequences for consumers can be devastating. Many Americans are still reeling from the impact of the financial crisis. Retirement plans may be in doubt or postponed due to depleted investments.
Yet, just as it has for generations, New York Life stands safe and secure. As a result, our policyholders have come to count on us during both good times and bad.
Back in 2008, New York Life CEO Ted Mathas said, "We were built for times like these." And in fact, New York Life's ability to withstand the impact of the economic disaster was no accident. The company is specifically structured and managed to weather just such environments. While New York Life is built for times like these, it can also be said that New York Life is built for all times. Because even in less turbulent market environments, New York Life continues to provide unwavering value and security.
We are built on four basic cornerstones:
- The necessity of financial strength to underpin all promises.
- The role of mutuality in protecting policyholders' interests.
- The social and financial imperative of life insurance.
- The value of our career agency system.
Top marks for financial strength.
As a consumer, it's good practice to do your homework when purchasing life insurance. After all, what you're really buying is a promise that the life insurance company will make good on its obligations to you. A life insurance company that remains only one of two with the highest ratings currently awarded for financial strength* is clearly a wise place to start when looking for security.
The mutual advantage: Putting policyholders first.
New York Life is the oldest mutual life insurance company in the United States. A mutual insurance company, simply put, is a company not publicly traded and therefore without shareholders. With a mutual insurance company, customers who purchase certain "participating" products—such as whole life insurance—are entitled to vote in the board of directors elections and to share in any annual dividends that may be declared. These policyholders have the right to expect the company's highest priority to be safeguarding their interests.
In contrast, publicly traded life insurance companies serve more than one constituency. Along with their policyholders, they must satisfy the needs of their outside investors. A primary responsibility of these companies is to provide the best possible return on their shareholders' investment.
Mutuality at work: New York Life's investment strategy.
We rigorously control expenses, and we publish financial reports for our policyholders and other stakeholders. In other words, we combine the results-driven culture of a publicly owned company with the policyholder focus of a mutual company. For a copy of the 2015 Report to Policyholders, see http://www.newyorklife.com/report-to-policyholders/2015.
At New York Life, our investment philosophy is based on careful risk-return analysis. The guiding principles and disciplines we believe form the basis for sound investing include:
- We maintain diversification. No matter how attractive an investment opportunity is—we avoid outsized stakes in any single investment. Because of this, we have had very low levels of exposure to individual firms. While New York Life is not immune to what occurs in the financial markets, by maintaining diversification and adjusting credit limits depending on credit quality—no one single troubled investment should cause us, or you, undue concern.
- We conduct our own research. Rather than relying on ratings agencies such as S&P or Moody's to do our work for us, we independently make our own investment decisions based on our own bottom-up research.
- We insist on getting paid for taking risk. If we do not think a security is priced right, we will not invest.
- We take a long-term view. We invest for the long term because we make long-term commitments to our policyholders. We will and do forsake the potential of short-term gains in order to preserve long-term safety.
- We maintain ample liquidity. We ensure we have enough liquid assets to meet our obligations to our policyholders.
- We don't blindly follow the crowd. We have learned over the years to avoid the frenzy of overheated markets and panics when markets tumble.
Your agent and customer support.
New York Life's career agency system is the heart of the company. As evidence of the quality training and expertise of our agents, New York Life agents have led the Million Dollar Round Table (the premier association for excellence in the life insurance industry) for 61 consecutive years. We believe our policyholders should always be able to rely on top-level service from their agents.
Held to the highest standards, your agent's mission is to ensure you are given the greatest possible attention and to assist you both today and as your needs change, well into the future.
Superior service.
Underpinning the value of a New York Life agent is a support system committed to enhancing experiences and transactions with the company. The company's Virtual Service Center (VSC) offers cutting-edge solutions to streamlining transactions. In fact, policyowners can view and navigate the VSC on Web-enabled handheld devices—whenever and wherever self-service is needed!
In short, you can count on us—always.
That's why New York Life is The Company You Keep®.
*The "highest ratings currently awarded" refers to the highest ratings currently awarded to any life insurer, specifically: A.M. Best A++ (as of 7/1/15); Fitch Ratings AAA (as of 8/11/15); Moody's Aaa (as of 8/6/15); and Standard & Poor's AA+ (as of 6/24/15). Source: Third party reports.


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- Color
- Tan
Tan - For olive-to-tan skin with neutral undertones
bareMinerals is revolutionizing the makeup world again with Matte Foundation Broad Spectrum SPF 15 infused with RareMinerals ActiveSoil Complex™.
Our groundbreaking formula absorbs excess oil and eliminates shine without drying skin for a flawless, natural matte finish all day. Clinically proven, it delivers extraordinary skincare benefits to dramatically improve the appearance of your skin over time. The foundation is enriched with our unique, proprietary 100% pure RareMinerals ActiveSoil Complex, which minimizes pores and promotes cell turnover for fresher, smoother skin while protecting skin from environmental damage.
Packaged in our new, innovative Click, Lock, Go™ sifter, you can take Matte Foundation Broad Spectrum SPF 15 anywhere you go - no spills, no leaks, no worries.
Choose Warm Deep for deepest skin with intense yellow-olive undertones.
Size: Large
Matte Foundation Broad Spectrum SPF 15 uses only the purest, highest quality ingredients and none of the chemicals or preservatives that can irritate skin. What you get is bare skin beauty with big skin benefits.
Plus, it improves your skin with the clinically proven power of RareMinerals ActiveSoil Complex, which:
Don't just take our word for it - look at what women are saying:
*Based on an independent consumer study.
Swirl, Tap, Buff Application:
REVIEW SNAPSHOT®by PowerReviews
Reviewed by 1 customer
light coverage
By Hippie Bri
from Tennessee
describe yourself Brand Buyer
- Easy To Apply
- Lightweight
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Best Uses
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This formula isn't much different than the original formula. This product seems like it would be better for oily or normal skin. It causes some flakiness on dry skin. The price is a little steep, but a little bit can go a long way if you need light to medium coverage.
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Bottom Line No, I would not recommend this to a friend
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Through our exceptional health
care services, we reveal
the healing presence of God.
What's NewGet the latest news on St. Mary's Hospital »
Madison, WI –Some people with H1N1 symptoms may be risking an unnecessary emergency room bill and could put other patients and healthcare workers at risk by not following Centers for Disease Control and Prevention guidelines for seeking emergency care. Rooms at all three hospitals have been filling up with people concerned about high fever, cough, chills, and other signs of influenza-like illness. Many are leaving the emergency room without a prescription for anything but chicken soup, rest and fluids.
That's why Madison's three largest hospitals have teamed up to let the community know that, at this point, normally healthy people with symptoms are no longer being tested for the H1N1 virus. For them, the doctor's best advice is really what mom prescribes: rest, fluids and acetaminophen for the fever.
People in the following high risk groups should call their physician if they develop flu symptoms:
The CDC recommends emergency medical care for the following symptoms:
In addition, children with the following symptoms should seek emergency care:


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Managing finance is something difficult to do but willy-nilly everyone should deal with such situation. The harder one is to manage the couple finance for those who are in relationship. You know that if you have a partner in life, financial management could be the sensitive issues for both of you. Since you live together, it is good for you to manage the finance together. It is something that you should communicate between you and your partner well. You know that finance plays the important role once you decide to live together and sometimes it determines your relationship condition. Hence, you might need several tips to manage the finance in relationship as follows:
- Create Expenses Note
What you should do when you live with your partner is note all the expenses that you spend together. Of course, every month you need to deal with so many bills, such as, utility bills, electricity bills, food expenses, fuels, and so on. What you should do is make not for all those things. You need to create a budget for this. Then, discuss with your partner whether you will use one of your accounts or pay it altogether.
- Make a decision
In order to manage the finance in relationship, you need to decide whether you will collect the money in one account or joint account. One account means that you separate the money with your partner. Meanwhile, for joint account, you will sum up the money together with two names of holder. This is so much easier for you to decide one of them. Make sure that you decide one of the options with no hard feeling and be strict to manage the financial.
- Financial Management
Life is not only about the bills that you should pay every month. As a couple, you need to get the time to have fun and of course, it needs money. Well, in this case, you should remain some money to have fun like dinner or holidays. On the other hand, you need to have some for savings. In addition, you need to decide whether all the debt payment will be collected in one or separately. In this case, all the things should be clearly made. Even, you need to determine who will take the responsibility to monitor the financial management?
- Be Transparent
Healthy relationship deals with communication including the finance. In this case, you need to be transparent for the expenses that you have spent and so your partner does. Also, when you take the cash loan, you need to tell your partner and do not make it as a surprise which may hurt one of you. Everything should be clearly made to avoid the miscommunication and wrongdoing.
Those are the things that you should know to manage the finance in relationship. Even it is harder than managing personal finance, but you should do this. It will make everything seems to be well organized. To get clear information, please kindly visit http://www.topratedcashloans.net/managing-finances-in-a-relationship.


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Annual Members Juried: Duets
Our most intimate relationships are one-to one. This year's Annual Members' Juried Exhibition features fourteen artists who present two examples of their work, inviting the viewer into a dialogue generated by each pair. Perhaps the most literal examples of the duet are the precisely choreographed performances by the duo Jay & Jae, whose videos document their synchronized efforts to negotiate objects and tasks. The intermedia pairings of John Schlesinger, Nicole Lenzi, David Meyer, Artemis Herber, Ron Longsdorf, and Nichola Kinch use surprise and wit to enchant familiar domestic spaces. Other artists—Annette Seidenglanz, Jenna Weiss, and Delainey Barclay—use abstraction to explore rhythm and emotion. Daniel Forrest Hoffman, James Lipovac, and Jessica Hoffman revisit archaic formats of communication for new creative possibilities. The paired works in Duets activate our imaginations about how the process of creating intimacy with people, places, and things is never static.
—Daniel Belasco, Juror
JUROR: Daniel Belasco is a curator and art historian specializing in modern and contemporary art and design. In 2010, Belasco co-curated The Dissolve, SITE Santa Fe's Eighth International Biennial. Since 2007, he has been Henry J. Leir Associate Curator at The Jewish Museum, New York City, where he has organized the exhibitions Reinventing Ritual (2009) and Shifting the Gaze: Painting and Feminism (2010) while managing the museum's contemporary Judaica program of acquisitions and commissions. Belasco has published in numerous art and cultural journals and lectured around the country. He holds a PhD from the Institute of Fine Arts, New York University, and a BA from Amherst College.
Exhibiting Artists
Delainey Barclay • Wilmington, DE
Artemis Herber • Owings Mills, MD
Daniel Forrest Hoffman • Philadelphia, PA
Jessica Hoffman • Philadelphia, PA
Jay & Jae • Wilmington, DE
Nicola Kinch • Elkins Park, PA
Nicole Lenzi • Baltimore, MD
James Lipovac • Philadelphia, PA
Ron Longsdorf • Spartanburg, SC
David Meyer • Newark, DE
John Schlesinger • Philadelphia, PA
Annette Seidenglanz • Malvern, PA
Jenna Weiss • Philadelphia, PA


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Saturday, Dec. 15, 2012
7:30 p.m. update:
NEWTOWN, Conn. (AP) -- The father of the gunman in the Connecticut school rampage says his family is saddened and struggling to make sense of what happened.
Peter Lanza says in a statement released late Saturday that "our family is grieving along with all those who have been affected by this enormous tragedy."
Investigators are trying to learn more about Lanza's son, 20-year-old gunman Adam Lanza, who gunned down 26 people including 20 children at a Newtown elementary school. They've questioned his older brother, who's not believed to have been involved in the rampage.
Peter Lanza says "no words can truly express how heartbroken we are" and that relatives are "in a state of disbelief and trying to find whatever answers we can."
(Copyright 2012, The Associated Press)
NEWTOWN, Conn. (AP) -- Connecticut State Police say a gunman who massacred 26 children and adults at an elementary school before committing suicide forced his way into the building.
Lt. Paul Vance said Saturday morning that the suspect was not voluntarily let into Sandy Hook Elementary School in Newton.
Authorities say 20-year-old Adam Lanza shot his mother on Friday, drove her car to Sandy Hook Elementary School in Newtown, and shot 20 children, six adults and himself.
Vance says the medical examiner is still working on identifying the victims.
(Copyright 2012, The Associated Press)
NEWTOWN, Conn. (AP) -- A law enforcement official says that the Connecticut school shooter brought three guns into the elementary school where he killed 26 children and adults and that the weapons were registered to his slain mother.
The official was not authorized to discuss information with reporters and spoke on condition of anonymity.
The official says a Glock and a Sig Sauer, both pistols, and a .223-caliber Bushmaster rifle were found in the school after the massacre Friday.
The official says that a fourth weapon was found outside the school and that investigators have been going to shooting ranges and gun stores to see if Lanza had frequented them.
(Copyright 2012, The Associated Press)
WASHINGTON (AP) — President Barack Obama has addressed a stunned nation for a second time regarding the Connecticut school massacre, saying the country is "heavy with hurt."
In his weekly media message, Obama said, "We grieve for the families of those we lost. And we keep in our prayers the parents of those who survived. Because as blessed as they are to have their children home, they know that their child's innocence has been torn away far too early."
Police say 20-year-old Adam Lanza killed his mother at home and then massacred 26 people, including 20 children, at an elementary school in Newtown. Lanza, committed suicide.
Obama says he and his wife, Michelle, "are doing what I know every parent is doing - holding our children as close as we can and reminding them how much we love them."
Republicans ceded their time so that Obama could speak for the nation.
(Copyright 2012, The Associated Press)
Initial report:
NEWTOWN, Conn. (AP) — Authorities say they may be able to release the identities of the victims of the Connecticut school shooting on Saturday morning.
State police Lt. Paul Vance said Friday evening that officials were "cautiously optimistic" that they could have all the identities pinned down by the morning.
He says that authorities already have preliminary identities but that "it's a very meticulous process."
Family and friends have been identifying some, including the school's principal. When she took the job in 2010, Dawn Hochsprung told the Newton Bee that she couldn't image "a more positive place to bring students to every day."
Twenty-year-old Adam Lanza is believed to be the gunman who shot up Sandy Hook Elementary School in Newtown on Friday, killing 26 children and adults, then himself.
(Copyright 2012, The Associated Press)


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Simple prostate removal is a procedure to remove the inside part of the prostate gland to treat an enlarged prostate. It is done through a surgical cut in your lower belly.
Prostatectomy - simple; Suprapubic prostatectomy; Retropubic simple prostatectomy; Open prostatectomy; Millen procedure
You will be given general anesthesia (asleep, pain-free) or spinal anesthesia (sedated, awake, pain-free). The procedure takes about 2 to 4 hours.
Your surgeon will make a surgical cut in your lower belly. The cut will go from below the belly button to just above the penis. The prostate gland is removed through this cut.
The surgeon removes only the inner part of the prostate gland. The outer part is left behind. The process is similar to scooping out the inside of an orange. After removing part of your prostate, the surgeon will close the outer shell of the prostate with stitches. A drain may be left in your belly to help remove extra fluids after surgery.
An enlarged prostate can cause problems with urinating. This can lead to urinary tract infections. Taking out part of the prostate gland can often make these symptoms better. Before you have surgery, your doctor may tell you some changes you can make in how you eat or drink. You may also be asked to try taking medicine.
Prostate removal can be done in many different ways. The kind of procedure you will have depends on the size of the prostate and what caused your prostate to grow. Open simple prostatectomy is often used when the prostate is too large for less invasive surgery. This means that the prostate weighs 100 grams or more. However, this method does not treat prostate cancer. Radical prostatectomy may be needed for cancer.
Prostate removal may be recommended if you have:
Your prostate may also need to be removed if taking medicine and changing your diet do not help your symptoms.
Risks for any surgery are:
Other risks are:
You will have many visits with your doctor and tests before your surgery:
If you are a smoker, you should stop several weeks before the surgery. Your nurse or doctor can help.
Always tell your doctor or nurse what drugs, vitamins, and other supplements you are taking, even ones you bought without a prescription.
During the weeks before your surgery:
On the day of your surgery:
You will stay in the hospital for about 3 to 4 days.
You will leave surgery with a Foley catheter in your bladder. Some men have a suprapubic catheter in their belly wall to help drain the bladder.
Many men recover in about 6 weeks. You can expect to be able to urinate as usual without leaking urine.
Han M, Partin AW. Retropubic and suprapubic open prostatectomy. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 94.
Thiel D, Petrou SP. Electroresection and open surgery. Urol Clin North Am. 2009;36(4):461-470, vi.
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Fire damages Cheviot home
No injuries reported
Published 7:58 AM EST Feb 21, 2013
Firefighters say a fire that damaged a Cheviot home Thursday may have started with an electrical problem.
Crews were called to 4134 Homelawn Street to find flames in a second-floor bedroom.
Everyone in the house was able to escape without harm.
Damage was mostly contained to the second floor. There was no immediate estimate on the damage cost.
Copyright 2013 by WLWT.com All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Eighth-grader Grant Morgan from The Peak School was recently named a recipient of the Caroline D. Bradley Scholarship. The merit-based scholarship is awarded annually to gifted middle school students who show excellence in academics and leadership.
Approximately 15 students are chosen from thousands of applicants across the country. Morgan was granted a scholarship to The Peak School for all four years of high school.
"Grant is not content to accept knowledge at face value," head of school Rebekah Jordan said in a prepared statement. "He is often the first and last student in the room with his hand up, probing for more and challenging the status quo — always with the utmost respect for the topic, his teacher and his peers."
The scholarship was founded in 2002 on the basis that gifted young students could reach their full potential in a learning environment suited to their individual needs and goals.
The Institute for Educational Advancement awards the Caroline D. Bradley Scholarship to "exceptionally gifted middle school students who exhibit advanced intellectual talent and have the ability to demonstrate academic and personal excellence."
The four-year high school scholarship covers day student tuition or an approved alternative educational program. The award does not cover boarding expense, but textbooks may be covered based on need.
Winners also receive guidance when identifying and applying to high schools, and enter a peer network with alumni from Harvard University, Yale University and other prestigious colleges.
A Caroline D. Bradley scholar is identified as a student who "excels academically, displays a genuine quest for knowledge, thrives in the discovery process, is a leader among peers and embraces the ideals of integrity and honesty."
The Peak School is an independent middle and high school in Summit County.


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SAN FRANCISCO -- A San Francisco Bay area woman is California's newest millionaire after turning in her winning California lottery ticket.
Lottery officials said Wednesday that Thi Nguyen is $14 million richer after coming forward with a winning ticket from the SuperLotto Plus jackpot drawing on September 29th.
Nguyen, who lives in Milpitas, told lottery officials that she's not sure what she'll do with the money, but planned to help her family and donate to her temple.
Nguyen bought her ticket at a market in Milpitas, which will get a bonus of $70,000 for selling the winning ticket.
Copyright © 2012 by Bay City News, Inc. ... republication, re-transmission or reuse without the express written consent of Bay City News, Inc. is prohibited.