text:
OAKLAND -- Before the first game of the Bay Bridge Series, Giants manager Bruce Bochy reminisced about a time not long ago when the Bay Area's two teams were widely considered the best in their respective leagues.
"They're firing on all cylinders," Bochy said. "We blew a gasket, unfortunately, and backed off a little bit."
The free fall continued Monday night. The Giants fell to the A's 5-0 at O.co Coliseum, suffering their fourth shutout in eight games. They've dropped 19 of 26 overall and currently look incapable of keeping pace with an A's team that had an identical 43-28 record as recently as June 17.
"It's honestly (a little stunning) with the talent we have on this team," first baseman Brandon Belt said. "We're just not playing well right now. We've got to figure out something to pick this up, because we're better than this."
Bochy continues to preach that the Giants need to "get back to who we were," but it's becoming harder and harder to remember what that looks like. A team that was so solid defensively for the season's first two months allowed two unearned runs Monday on throwing errors. A bullpen that was one of the National League's best early on can no longer keep games close.
More than anything, a lineup that was absolutely relentless in April and May now goes down quietly far more often than not. The Giants scattered just five hits against Jesse Chavez and the A's bullpen. They've scored eight runs total in eight losses over the past 11 games.
"I don't think you ever like your approach when you get shut out," Bochy said. "And we've been shut out too many times. You look at the last couple of weeks and feel like lately we've had better at-bats. But their kid threw well. They have a great staff, great bullpen -- and we had a couple chances there. We just couldn't get that spark tonight to push us across."
Against a patient lineup, Ryan Vogelsong did his best to keep the Giants in the game, grinding through one jam after another. He never had a clean inning but limited the damage early. Vogelsong stranded a runner in each of the first four innings and wriggled out of a two-on, no-outs situation in the third.
The A's finally got on the board in the fifth after a close call on a hit-by-pitch. Craig Gentry appeared to get grazed on the top of his right hand, a ruling that stood after a Giants challenge. Gentry stole second, went to third on Coco Crisp's bunt single and scored on a ground out by John Jaso.
Vogelsong hit Josh Donaldson to lead off the sixth and was removed after giving up a one-out single to Jed Lowrie. Right-hander Juan Gutierrez entered from the bullpen and immediately surrendered a two-run double to Alberto Callaspo.
"That's what gets your team going -- a big hit," Bochy said. "They got one with runners on first and third."
Callaspo's knock was the kind the Giants grew so accustomed to early on. Those rallies have disappeared over the past month.
"We were a team that kept the line moving," Bochy said. "We've got some guys cold right now with the bats, and it's hard to keep the line moving when that happens."
Scutaro has missed the entire season with a lower back strain, but he told Bochy that he felt ready to return to the big leagues after making six short appearances for the Giants' rookie league team in Arizona. Bochy insisted that Scutaro go to Fresno for more at-bats and to make sure he can get through a full nine-inning game.
The Giants expect Scutaro to return in a part-time role after a few games in Fresno.
"We'd take that, as weak as our bench is," general manager Brian Sabean told this newspaper. "We'll take the starts he can give us but more so his bat off the bench. That's the greater hope right now. I don't think anybody expects him back as a regular starter."


text:
News and Events
Public Relations & Marketing
The top three speakers in the State are WCU�s Lanie Presswood (third place), Dan Hinderliter (center and first place), and Jake Markiewicz (second place).
A year of hard work came to fruition as the 15 students on the West Chester University Forensics (speech and debate) team dominated the other schools at the 2013 Pennsylvania Forensics Association State Championship, held on West Chester's campus Feb. 16 and 17.
WCU speakers took home gold medals in 6 of the 11 individual events. The team bested the second-place finishers, rival St. Joseph's University, by more than 150 points.
West Chester also boasted the top two debate teams and top four pentathlon speakers. Special recognition goes to Jillian Heagerty and Dan Hinderliter, who took first and second places, respectively, in persuasive speaking and thereby earned places in the Interstate Oratorical Competition. This tournament, the oldest oratorical contest in the United States, will be held in Shreveport, La., in April.
Individual awards were as follows:
Dan Hinderliter, senior Honors middle grades education/communication studies major (Allentown, Pa.): first place, Pentathlon; first place, dramatic interpretation; first place, program oral interpretation; second place, after dinner speaking; second place, persuasion; third place, duo interpretation with Lanie Presswood.
Jake Markiewicz, senior Honors communication studies major (Avondale, Pa.): second place, Pentathlon; second place, Parliamentary debate speaker; first place, Parliamentary debate with Jill Heagerty; first place, after dinner speaking; first place, informative speaking; third place, impromptu speaking; third place, program oral interpretation; fourth place, duo interpretation with Carl Sandberg; sixth place, extemporaneous speaking.
Lanie Presswood, senior Honors communication studies major and team president (Bloomsburg, Pa.): third place, Pentathlon; first place, impromptu speaking; third place, persuasive speaking; third place, after dinner speaking; third place, extemporaneous speaking; third place, rhetorical criticism; third place, duo interpretation with Dan Hinderliter.
Joe Tetreault, senior history education major (Southampton, N.J.): second place, dramatic interpretation; second place, poetry interpretation; second place, rhetorical criticism; fifth place, program oral interpretation.
Ashley Murphy, junior Honors English education/special education major (Lake Ariel, Pa.): first place, Parliamentary debate speaker; second place, Parliamentary debate with Erik Starn; third place, informative speaking; fourth place, program oral interpretation; fifth place, rhetorical criticism. Carl Sandberg, junior Honors philosophy major (international student, Norway): fourth place, duo interpretation.
Jillian Heagerty, sophomore Honors English major (Glen Mills, Pa.): fourth place, Pentathlon; first place, persuasive speaking; second place, informative speaking; fourth place, rhetorical criticism.
Imani Thomas, sophomore Honors communication studies major (Wyndmoor, Pa.): fifth place, poetry interpretation; seventh place, duo interpretation with Carla Agbiro.
Erik Starn, sophomore Honors communication studies major (Wayne, Pa.): second place, Parliamentary debate with Ashley Murphy.
Carla Agbiro, freshman psychology/political science major (Philadelphia, Pa.): seventh place, duo interpretation with Imani Thomas.
With only two regular season tournaments left, coach Mark Hickman, WCU's Director of Forensics, and graduate assistant Kelsey Hockenberger are looking forward to the team's continued success at the Pi Kappa Delta national tournament in March and the National Forensics Association Championship in April.
For more information on WCU Forensics, visit communication.wcupa.edu/forensics.

subset: commoncrawl


text:
Grandparents: Near or Far, Still Amazing
This is a guest post by Cheryl Cohen, who is the Online Community Director of IAN Project at Kennedy Krieger Institute.
Here's an interesting family photo from 1934. In it is my mother at age four, my grandmother, my great-grandmother (who was partially paralyzed by polio), and my great-great grandmother. It was the Depression. These four generations lived together in a small row house in Philadelphia. Like many other multi-generational households, they cooked and ate meals together, shared economic resources, and raised the children. Though the percent of the population living in multi-generation households has declined since then (although it is now on the rise), grandparents and other members of the extended family still play a large role in helping raise children – especially when a child has special needs.
With the help of grandparents, who wanted to share their experiences and learn about the role of other grandparents, the researchers at the Interactive Autism Network (IAN) developed the Grandparents of Children with Autism Spectrum Disorders Survey. We knew that grandparents played a major role in helping their adult children and their grandchildren. But, we wanted to learn (using scientific methods) how grandparents support the emotional and economic needs of their adult children and their affected grandchildren. We also wanted to know how having a grandchild with ASD had changed their lives.
More than 2,600 grandfathers and grandmothers of grandchildren with ASD participated in this survey, which we administered on the Internet. They came from all 50 U.S. states and the District of Columbia, and every kind of locale, with 17% from cities, 23% from rural areas, and 60% living in the suburbs. They represented a wide age range, from people in their 40s to people in their 80s, and had varied educational backgrounds. Though the goal of the survey was to gain knowledge about the nature and extent of the role of grandparents, we also wanted to find out the support, services, and information needs of grandparents.
Participating grandparents told us some very interesting things:
- So that the grandparent could help his/her grandchild, 20% of the families had moved closer to each other. Nearly 8% had combined households.
- About 30% were the first to notice that there was a problem in their grandchild's development.
- Nearly 90% felt that the experience of facing their grandchild's situation together had brought them and their adult child closer.
- About 6% of the grandparents told us that a family situation had become so untenable they had taken on the role of parent.
- While 86% of the respondents were coping very well or fairly well, 14% reported that they were coping poorly.
Find out more IAN's two-part series, Grandparents of Children with ASD.
Learn about the Interactive Autism Network (IAN) and how you can participate.
Interested in statistics on the multi-generational household in the United States? Visit the Pew Research Center's The Return of the Multi-Generational Family Household.
June 1, 2010 at 2:44 pm
Wow very interesting.See grandparents are AWESOME they do love their little ones so so much.
June 1, 2010 at 4:42 pm
This is great! My son has PDD-NOS and ADHD, if it wasn't for my mother I do not know how I would be coping! She is my support system and helps me to take care of my self, as much as my son and daughters!
December 30, 2010 at 7:29 pm
I just found out yesterday that one of my precious grandsons has been diagnosed with PDD-NOS. Our family is in shock and need to know what to do now. What is his future like? My daughter homeschools all her children and I want to help as much as I can. What can we do? Where do we turn?? Charlotte MeeMaw
June 2, 2010 at 11:16 am
Awesome! My son is 4 and has PDD. If it wasn't for my parents, especially my mom, I don't know what I would do. They love him so much and he loves them too!
June 3, 2010 at 11:08 pm
Grandparents are great! I don't know what I would do without my parents' help, love, and support. They have been my rock through it all. Our son has the BEST grandparents. They help me with him, but also help our older child not feel left out. My kids LOVE their grandparents (and we do, too).
June 23, 2010 at 10:11 pm
How come none of the grandparents have autism?
October 17, 2010 at 2:09 pm
Our granddaughter has Autism. She is almost 4, not talking yet, but working very hard with her therapy. Her parents are the best! They take her 45 minutes one way to therapy, then return at 7:30 PM to get her ready for the next day. She also goes to full time school. We live many states away are are not able to help them out. We love the stories of her progress and encourage them all the time. Cannot wait to see her on our next trip.


text:
Since my first exposure to an Apple ][ in sixth grade, I haveinteracted with computers primarily through a text-basedinterface. From my first `PR#6' command to this little journal entry(I tend to use Emacs for writing), I eschew fancy heavy-weightprograms in favor of the simplest program possible. (I know, I said Iuse Emacs. Within that contradiction is the essence of simplecomplexity. Substitute vi if you wish.)
I admired the Apple //gs, and then the simple interface of the firstMac. But in the end, windowing systems are great for one thing:opening multiple terminals for simultaneous use. Don't misunderstand:I use web browsers, and I sometimes fire up the Gimp, and I have beenknown to use Blender. I've playedwith the eye-candy of Enlightenment since DR7. I evenrather enjoy the absurdity of Beryl and Compiz. So I understand theappeal of the WIMP (windows, icons, menus, and pointing device)-typeinterface.
But, as an old-timer who remembers learning about the basis ofcomputing from the ROM listings in the back of the Apple ][ manual, Ithink all of you youngsters have it too easy these days, with yourfancy candy-like interfaces that really haven't progressed much beyondthe old four-bit grays of the original NeXT. There's no realchallenge, and no real progress.
The only interface I want to see replace the command line is nointerface at all. I want computers to understand the context of aconversation, and to respond instantly with the information I require,or to perform the tasks I request. They should listen and record andsynthesize information, and interact as if they wereintelligent. (Actual intelligence is optional.)
Over the last couple of weeks, I have been exploring two available 3Denvironments: Croquet and Project Looking Glass. Thetwo projects take distinctly different approaches to their 3Denvironments.
Alice in Javaland
Project Looking Glass is fairly straightforward, and is the moremature of the two projects. Sponsored by Sun Microsystems and releasedunder the GPL, Project Looking Glass takes a minimalist approach to3D.
The Project Looking Glass (PLG, from here on out) environment isessentially an evolution of the current WIMP environment we all knowand love. If run as the primary X11 session, regular X11 applicationsappear as usual, with a title bar and standard buttons andwhatnot. The launcher at the bottom of the screen is a variation ofthe standard launcher such as those found in KDE, GNOME,Enlightenment, and just about every other desktop environment.
PLG provides some nice eye candy, such as parking windows on theirsides, which is really the same as using "window shade" features ofmany window managers. The best feature so far is the ability to attachnotes to the back of a window. This feature is driven by the titlebar, so you can add unique notes to anything with a unique title bar,such as web sites in Firefox, directories in terminal apps that setthe title bar to the current directory, documents in OpenOffice, andso on.
PLG native applications may float without the standard windowdecorations. For instance, the background chooser is a circular queueof images. You rotate through the queue until you find a pleasingbackground, and click a small floating checkmark button to select.
All-in-all, PLG is a pleasing, familiar environment without much toset it apart from other pseudo-3D environments like Compiz orBeryl. Unlike Beryl and Compiz, PLG provides a complete infrastructurefor building 3D applications, as long as you code in Java. (C++bindings are promised in the near future, for those masochists whoenjoy C++.)
Virtual croquet, anyone?
Croquet is acompletelydifferentbeast.Foregoing the standard WIMP-style interface, Croquet focuses on animmersive 3D networked environment. A direct descendant of the MMORPGaesthetic, Croquet replaces the desktop metaphor with an immersiveworld. The mouse pointer becomes an avatar.Applications become interactive objects. Even "legacy" X11applications are transformed into collaborative environments, allowingmultiple people to work or play simultaneously.
Your computer becomes your on-line world. You can grant individualspermissions to enter and interact with your world. Moving from worldto world is as simple as moving your avatar through a portal.Your world can be a simple plane, or an elaborate simulation.
The break from the traditional desktop is astonishing. By discardingthe old metaphors entirely, the Croquet team has opened up an entirelynew realm of computer interaction. Most promising is the peer-to-peersharing of environments. This transforms a network of computers into agiant on-line world, ready to explore and transform in a mannernatural to those who grew up on MMORPGs and file sharing programs likeGnutella.
Just as the PLG environment is tied to Java, Croquet is built onSqueak, a Smalltalk-derived language with a fun name.
My computer cries
Both Project Looking Glass and Croquet are promising looks at thefuture of computer interaction. PLG extends the desktop into thepsuedo-third dimension. Croquet demolishes the desktop metaphorentirely.
Both environments require a bit of processing clout. My poor littlelaptop cries every time I fire up either one. Strangely, thefully-immersive Croquet performs better, at least for the demoenvironments. I kept losing track of the pointer in PLG. In Croquet, Ikept losing track of my world.
On slightly beefier machines with better accelerated 3D support, moreRAM, and faster hard drives, both environments are responsive andclean.
As you can probably tell, I prefer the game-like approach of Croquetover the rather conservative Project Looking Glass. However, thisradical departure from entrenched environments may be too unwieldy tocatch on. As in the real world, traveling through the world may beprohibitively expensive, time-wise.
Either way, both environments are impressive first steps toward thefuture. With them, I still have to intentionally interact with thecomputer, but at least it's a lot more fun.
What's the point of talking
What's the point of talking about it when you don't have screenshots? Any links to demo videos?
Demo videos
The tutorial section of Croquet has a few interesting videos. The Project Looking Glass video isn't as exciting, but it certainly displays some of the cool stuff present in PLG.
There are several screenshots linked in the body of the journal entry; I didn't call them out specifically as screenshots, but they are there.
Good Article
I thought introducing someone like me to a project I haven't heard of (Croquet) and explaining how it works is a good enough "point of talking." I don't think screenshots are a requirement to write an article by any stretch. URL's are far more usefull anyways and they were given (there are screenshots if you follow the URLs).
However, my real point is that if you want screenshots or demo videos you should ask politely.
don't understand
I just didn't understand anything what you are talking about. What machine configurations are you using? Some screenshots would be appreciated.
Machine configuration
I use a Presario X1000, an aging 1.4GHz Pentium M, with an ATI Radeon R250 Lf video card. I use Debian as my primary OS. Neither system performed well, as you might imagine.
I linked to screenshots hosted from the main application sites, rather than embedding my own. The screenshots were already there, with better illustrations of what the system can do, as I don't have the cool Mars simulator, or the nifty particle system in the earth demo.
Follow the links provided in the body of the journal entry to see the interesting pictures.
for ubuntu users Project looking glass
I would suggest
this article for ubuntu users how to install Project looking glass with screenshots
Please categorize your articles
In this case, it's not "Two views of the 3D Desktop". I use a few 3D Desktops on my Windows computer. This is for the Mac. Goodie for you.
If you are talking about a specific computer, and ignoring other computers, please specify which one you are talking about.
"MAC: Two Views of the 3D Desktop" tells me this is a Mac article. This is the Internet, not everyone uses a Mac.
not just mac, linux also, and plg also windows
Why is searching to hard for you?
This has nothing to do with mac's (besides that you are on a free software magazine's website)
Since any computer can run linux, and since these are demo's i'd suggeest using a live-cd or seperate harddisk anyway.
Quit your whining, and just see what the world beyond windows has to offer.
A quick look at the 2 sites
A quick look at the 2 sites using the links provided shows me that there are downloads for both Mac/linux and for Windows, so this is not platform-specific. Caveat: I have not actually downloaded and installed yet.
Only two views
Well, I named it two views because each of the two systems provides a different way of using 3D space to, ahem, "enhance the computing experience."
Sorry about that. Now I have to clean out my mouth with soap.
Both systems can run on MS-Windows. In fact, I tested Croquet on an MS-Windows machine, and it worked just fine, except that it was on an MS-Windows machine.
My wife uses a Mac. I do not. I use Debian, a distribution of GNU/Linux. If you want to give it a try, may I suggest Ubuntu? It's a fairly nice Debian-derived distribution.
Oh, and good luck with that MS-Windows machine of yours.
It's a counterpoint and yet a nice expansion on article http://www.freesoftwaremagazine.com/node/1577 (ringing my own bell here).
Now, has anybody tried to implement an LCARS interface? It doesn't look to be based on the WIMP design... :P
PLG was in fact the first 3D desktop environment I remember seeing demoed, but it used to be cumbersome and unstable - it required solid 3D acceleration and heavy CPU use due to the Java foundation.
It has been copied by MS for Vista's Aero Glass (3D elements on .Net), with known results: slow and unstable.
While a lesser revolution, I consider AIGLX+Compiz/Beryl the best compromise between compatibility, 3D use and new functionalities.
Not to mention that while still in alpha stage, it is actually quite stable. Nice article, though.
Now, has anybody tried to implement an LCARS interface?
You mean, like this?
While a lesser revolution, I consider AIGLX+Compiz/Beryl the best compromise between compatibility, 3D use and new functionalities.
PLG and Aero Glass are both limited, and Microsoft didn't copy the only interesting things about PLG (the ability to scribble notes on the back of windows, for example). Otherwise, it's all just a bunch of pretty graphics used to add appeal to the same old 2D WIMP environment.
The same thing is true of Compiz and Beryl: they are a 2.5D view of the world, in that 3D is used only for effect, rather than to add much to usability. Most of the true usability enhancements of the new generation of fancified desktops could be accomplished without 3D at all, like the minimizing effects to show you were your windows went.
Getting back to LCARS: notice the (fictional) primary interface to the (fictional) LCARS system is still voice. The screens are used to display data, and to augment input. I think this is the way it should be. Keyboards will still be useful, as a bunch of people sitting around talking to their computers will make for a noisy office.
At least, that's my assessment. I may be way off.
a Wii-zard approach, maybe?
For 3D, I'd say that a new input device might be necessary: a Wii nunchak is the first step in this direction, but I was truly amazed (and interested by how old it is, in fact) by the interface used by Tom Cruise in Minority Report (see another of my blog posts...). Funnily, it reminded me of Nintendo's first approach of 3D control: the Power Glove on the original NES/Famicom.
Voice is an idea, but not for navigation: I'd say it's good for extended data input, but it's too... imprecise for actual navigation, moreover it would be very hard to localize.
Note, I think there should be a way to add the windows back sticky notes to Compiz/Beryl - modular design and window manager are the only actual requirement for these, but you may want to write one yourself...
A computer is like air conditioning: it becomes useless when you open windows.
Navigation speed is the real problem!
Navigation and quality of response are the real issues when using fly through data spaces. 3d may added if needed, but is hardley a goal in itself since most information uses two dimensions. This example is very fast and responsive: http://www.2GoTo.com It uses a variable speed zoom on double click drag and variable speed pan on drag to navigate an infinitely large plane. Also, when zillions of windows are used, it helps to hide scrollbars and menus till needed.
Thank you for making reference to PR#6. My idiot friends act like it never existed and subsequently don't get my PR#6 humor (but make an up up down down left right left right....joke and they roll in their seats).
Real and virtual 3D
Are they 3D emulations only? As long as we don't have some 3D glasses or other 3D technology connected to the computer, it still is a 2D environment. True progress will come with real 3D.
It's science fiction for now, but I think real 3D will be the next true revolution very soon. UNIX, personnal computers, Xerox GUI and Internet changed the face of the world. The next step is real 3D. Next generations will "eat" real 3D stuff, like programs, games, machine operation programs and the like. The whole reality will be mixed with virtual reality. You can't leave your computer now? Wait for a little decade or two at most, and we will litterally "live" in it.
3D desktop is the beginning of it. I mean $$$.
They're alright, but....
they're really not going to be able to run smoothly until computing hardware is fast enough to run them efficiently. of course, core 2 duo processors can most likely handle running any sort of 3d desktop environment, providing that you've got a really good video card. i have the latest build of project looking glass installed on my pentium 4 windows xp home system, and it's a pretty inventive idea, but it's still lacking in some functionality, most likely because i'm not running linux.
Pleas check your facts or typos
The grayscale NeXT computers had 4 levels of gray, meaning it was a 2-bit display, not 4-bit, in which case it would have had 16 levels of gray.
You are correct, Sir
You are indeed correct. The NeXT was a two-bit greyscale system when first released. As my kid would say, "My bad." Really, it's my faulty memory. I was sure I knew that.
It was amazing how good that system looked with only white, black, and two shades of grey. I miss the NeXT.
What about 3DNA
Have you seen the 3DNA desktop enviroment. I may be missing the point, and when I tried it a couple of years ago it was slow, but I would be interested in any opinions. (It is for windoze though.) http://3dna.net/
Hadn't seen that
3DNA looks similar in concept to Croquet, only without the networked transparency. The true appeal of Croquet is the peer-to-peer world sharing. Navigating a regular 3D world to use your computer would be less efficient than just using a 2D space efficiently.
The 3DNA screenshots looked very nice, though. It looks like a polished product. Unfortunately, I don't use MS-Windows, so I will not be able to investigate it.
web design new york
Cheers for the info. It was a good read.


text:
Editor's note: This column, submitted by Vail Resorts, showcases the nonprofits that the company supports through its Vail Resorts Echo program.
EAGLE COUNTY - More than 2,700 kids across the country will hit the slopes this season through SOS Outreach, a Colorado-based nonprofit organization dedicated to helping at-risk youth excel in the classroom and learn critical life skills on the mountain. SOS participants face a variety of challenges, including trouble in school, living in low-income households and speaking English as a second language. Through a variety of curriculum stressing responsibility, self-confidence and service, SOS youth learn five core values: Courage, discipline, integrity, wisdom and compassion. While former SOS participant Francisco "Paco" Holguin left the mountains last fall for the East Coast, he found himself drawing upon his SOS values during his first semester at the Massachusetts Institute for Technology.
The oldest of three and the first generation of his family to be born in the U.S., Holguin enrolled with SOS Outreach as a way to get involved in his community. After eight years with the program, Holguin graduated from Vail Mountain School last year and received a full ride scholarship to MIT. Holguin says he relies upon SOS's five core values frequently, and emphasizes integrity as being particularly important with schoolwork.
"There is a sense of integrity in terms of doing your own work," Holguin said. "Homework is done collaboratively with other people, but come test time, you're on your own and you have to know your material."
Holguin also reflects on the courage he's also found recently, especially when searching for a summer research internship to augment his selected major of physics.
"Both professors and older students say that in order to get a research position, you have to have the courage to ask for and seek out what you want," he said. "If know that if I don't take the chance, I won't receive the position.
Vail Resorts values the importance of integrity, courage and wisdom, and recognizes the impact SOS Outreach and these lessons make on youth like Holguin.
"By supporting SOS Outreach with both cash and in-kind contributions, Vail Resorts provides that once in a lifetime experience to kids who might otherwise miss out on the iconic mountains of their own backyard," said Chris Jarnot, senior vice president and chief operating officer at Vail Mountain. "In addition to teaching youth to ski or snowboard, we appreciate that SOS Outreach also stresses leadership, the importance of community service and other key life lessons."
Arn Menconi is executive director of SOS Outreach. Through Vail Resorts Echo, Vail Resorts hopes to connect its communities to its efforts - from on the ground conservation programs to grants for local schools. Aimed at both protecting the natural resources that surround the resorts and helping build stronger communities where its employees live and work, Vail Resorts Echo encompasses three core efforts: environmental stewardship, charitable giving and community engagement. Learn more at www.vailresortsecho.com.


text:
About the Book
"We have the intriguing possibility that the next great American author is already in print." —Fort Worth Star-Telegram
When Sheila McGann setsout to redeem her disgraced brother, a once-beloved Catholic priest in suburban Boston, her quest will force her to confront cataclysmic truths about herfractured Irish-American family, her beliefs, and, ultimately, herself. Award-winning author Jennifer Haigh follows hercritically acclaimed novels Mrs. Kimble and The Condition with a captivating, vividly rendered portrait of fraying family ties, and the trials of belief anddevotion, in Faith.
It is the spring of 2002 and a perfect storm has hit Boston. Across the city's archdiocese, trusted priests have been accused of the worst possible betrayal of the souls in their care. Estranged for years from her difficult and demanding family, Sheila McGann has remained close to her older brother, Art, the popular, dynamic pastor of a large suburban parish. When Art finds himself at the center of the maelstrom, Sheila returns to Boston, ready to fight for him and his reputation. But what she discovers is more complicated than she imagined as the scandal forces long-buried secrets to surface.
Elegantly crafted and sharply observed, Jennifer Haigh's Faith is a haunting meditation on loyalty and family that demonstrates how the truth can shatter our deepest beliefs—and restore them.
Educator and Librarian Resources
Critical Praise
"Both riveting and profound. . . . An incredibly suspenseful novel." — Washington Post
"A masterpiece of tension and tenderness." — More magazine
"Luminous. . . . The novel has the magnetic, page-turning quality of a detective thriller, but the clues here lead not to objective proof but to insight into a family both vividly specific and astonishingly universal. . . . . Wise." — O magazine
"Haigh deals with complex moral issues in subtle ways, and her narrative is beautifully, sometimes achingly poignant." — Kirkus Reviews (starred review)
"With an exquisite sense of drama and mystery, Haigh delivers a taut, well-crafted tale. . . . Indelibly rendered characters, suspenseful pacing, and fearless but sensitive handling of a controversial subject will make this a must-read for book discussion groups." — Booklist (starred review)
"Haigh's fourth novel draws you in. . . . You'll be hypnotized until you know where it stops." — Self
"FAITH is so emotionally rich, and its story so deftly delivered, that we're absorbed." — Wall Street Journal
"Expertly wrought. . . . Ms. Haigh, a subtle, serious novelist who happens to have a flair for capturing troubled family dynamics, never allows FAITH to become predictable. . . . Gripping. . . . Substantial." — New York Times
Product Details
- Imprint: Harper Perennial
- On Sale: 01/17/2012
- Trimsize: 5.313 in (w) x 8 in (h) x 0.793 in (d)
- Pages: 352
- List Price: 14.99 USD
- BISAC1: FICTION / General


text:
Marketplace: To Show or Not To Show
Marketplace, a daily economics news program heard on National Public Radio, featured a story on January 8, 2002 titled "Art Post-9/11." In this segment, reporter Beatrice Black explores the effects September 11th had on the art community.
In this lesson, you will act as a curator of a museum. Taking account of factors that affect profit, you will make management decisions, selecting art to be exhibited at your museum.
Read the transcript Art Post 9/11. As you read, analyze the following:
- What new considerations must a curator make prior to selecting an exhibit to show?
- How are some galleries or museums responding to the new threat of terrorism?
You, along with other students will act as the curator of a museum.
As the curator of an art museum, you are charged with the task of choosing a collection of work to highlight in an exhibit. You have been provided with three possible candidates: one unknown artist, one moderately-known artist, and one famous artist. You will have to reflect on many different economic factors to determine which of the three exhibits will be the most profitable for the museum.
Open the Interactive activity "Art Museum" and follow the instructions you find there.
Please review all three outcomes and then answer the following questions:
- Was your chosen exhibit profitable? Why or why not?
- What factors most influenced the outcome of your exhibit?
- What events or factors had you not previously considered?
- Were you surprised by the outcome? Why or why not?
$10 Billion to Host the Winter Olympic Games: Is it worth it?
In this EconEdLink lesson, you will learn about costs and revenues related to the '98 Winter Games in Nagano. Discussion questions about estimated benefits and costs to the host city are presented.


text:
New shopping carts are making their way to local Wegmans stores.
The special needs carts are designed to make shopping easier for people with special needs children. It is called Caroline's Cart.
The carts are labeled to ensure they are reserved just for those who really need them.
Several stores in Rochester appear to have them including Brockport, Penfield and Hudson Avenue.
Courtesy WHEC.com
Location, ST | website.com


text:
SOUTH GLENS FALLS, New York -- Two young boys were hospitalized Monday with serious injuries after falling 15 to 20 feet from an inflatable "bounce house" that was lifted into the air by a strong gust of wind.
The boys, ages 5 and 6, were taken to Albany Medical Center Hospital, one of them suffering from a traumatic head injury, South Glens Falls Police officer David Gifford said.
A 10-year-old sustained scrapes and bruises after falling from a much lower height.
Police declined to release the children's identities and an update on their conditions isn't known.
The inflatable house was not the commercial type rented for parties but a lightweight 8-foot-by-8-foot Little Tikes brand toy.
After the boys fell, it eventually went about 100 feet into the air, witnesses told police. "Luckily, they were tossed before it reached that height," Gifford said. "It was found hundreds of yards away. It came very close to power lines."
One of the boys fell onto a parked car and the other landed on asphalt, police said. The one who landed on asphalt was conscious and talking at the scene, police said. The bounce house was recovered at a school playground.
The structure had been staked to the ground, Gifford said. Police said the incident is considered a tragic accident and no charges are pending.


text:
Shop By
Nursing Bras
Full Figure Bras
54DD Bra
Need a bra that actually fits your shape and size?
Look no further! We offer a complete line of full figure bras in 54DD come in a variety of styles and colors to complete your wardrobe. Our DD-cup was designed to fit real woman just like you!
54DD Bras by Leading Lady
Molded Padded Seamless Wirefree Full Figure Bra
Size 54DD$38.00
Wirefree Sport Full Figure Bra
Size 54DD$26.00
Front Closure Leisure Bra
Size 54DD
$11.0050% Off!


text:
Elon Musk, founder and chief executive of Hawthorne rocket maker SpaceX, hastily called a news conference Friday in Washington, D.C., where he outlined an array of matters confronting his upstart company.
A cryptic e-mail was sent to media around 9 p.m. Pacific time Thursday that said he would "make an important SpaceX announcement" the next day at the National Press Club. The big announcement, however, wasn't quite clear. Musk made several revelations during the half-hour event.
First, he provided an update on SpaceX's goal of creating the world's first fully reusable rocket -- the holy grail in rocketry. Then, he said the company was filing suit against the U.S. Air Force to open up competition in rocket launches. Finally, he mentioned that SpaceX was building a launch facility in southern Texas.
Musk opened the event by talking about a reusable rocket because last week SpaceX launched its Falcon 9 rocket from Cape Canaveral Air Force Station in Florida to deliver supplies to the International Space Station for NASA.
After the Falcon 9 blasted off and the second stage was jettisoned, the first stage fell back to Earth before reigniting its rocket engines to cushion its attempted landing in the Atlantic Ocean.
Although SpaceX was unable to recover the first stage because of a storm and unsafe sea conditions, the company received data that said the rocket carried out a soft landing. The data were so promising that engineers believe SpaceX will be able to launch and return a booster by the end of the year.
The stage would then be refurbished and reused early next year.
"The data is very clear that it shows a soft landing," Musk said. "I think this bodes very well for achieving reusability."
For SpaceX, a reusable system could mean big savings in developing and operating rockets. These savings would help further bring down costs. SpaceX already keeps costs low -- rockets start at $56 million -- because it manufactures nearly all of its own parts.
SpaceX's sales pitch has worked on NASA. The company's launch last week marked the third flight in its $1.6-billion, 12-mission contract with the space agency to transport cargo to the space station.
But the company hasn't been able to break into the lucrative business of launching the U.S. government's most sophisticated national security satellites.
For eight years, the Pentagon has paid Boeing Co. and Lockheed Martin Corp. -- operating jointly as United Launch Alliance -- to launch the government's pricey spy satellites without seeking competitive bids.
The Air Force buys United Launch Alliance rockets to launch school-bus-size satellites for spying, weather forecasting, communications, GPS and other experimental purposes. The government pays the company nearly $1 billion each year whether it launches six times or none.
Musk has taken issue with the cozy partnership and wants a piece of the military's contracts, which could be worth as much as $70 billion through 2030.
"These launches should be competed," he said. "If we compete and lose, that is fine. But why would they not even compete it?"
The company plans on filing the lawsuit in the U.S. Court of Federal Claims next week.
In recent months, United Launch Alliance has been criticized for the way it builds its rockets. It uses a Russian-built RD-180 rocket engine on its Atlas V.
In the wake of Russia's seizure of Crimea, SpaceX has hammered United Launch Alliance over use of the engine. The Pentagon has directed the Air Force to perform a review to understand the implications of using the engine.


text:
Shop By Designer
Sign Up For Our Newsletter
Join Us
Give your pup's outfit a little pop of style with this lovely pink bow! Your pooch will look fantastic in this outfit! You will love everything from the detachable collar to the velcro closure. This is perfect for weddings and parties alike!
Enter your zip code or sign in to view shipping information. For more detailed information see our shipping page.


text:
Background: PMS running on AMD Athlox 64 X2 5600+, 2GB RAM, machine connected via 100 megabit wired ethernet.
There are 2 PS3's on the network, one wired (works perfect), one wireless, connected to a NetGear WGR614v5 router converted to a WAP, 802.11g. The WAP is upstairs almost directly above the wireless PS3. The PS3 reports a wireless signal strength of 100%.
90% of the media I play back is H.264 encoded MKV's with Dolby Digital 5.1 or DTS soundtrack at 720p or lower resolution (480p, as I have a lot of my own DVD rips, created with Handbrake). These all play back fine, on both the wired and wireless PS3, using tsmuxer and PMS.
Some of the DVD rips did not have a 5.1 audio track, so I used the straight PS3 preset in Handbrake to create them (720x480 resolution). They are MP4 files, with the AVC video and AAC 2ch audio. These playback natively on the PS3, not transcoding is necessary.
However, using PMS, the wireless PS3 stutters badly with these files, even though it plays back the other MKV's using the same level of video compression flawlessly (using tsMuxer transcoding). The difference is the MP4 files are handled by straight streaming versus transcoding.
If I use Mencoder, I can play back these files fine with the wireless PS3. This is not my preffered option.
If I force tsMuxer, the audio gets converted on the fly to Dolby Digital, and the file plays back without stuttering, but the audio and video go out of sync real fast.
As a test, I still had Tversity running on one of the other wired PC's on my network. I put the MP4s that were giving me problems on Tversity and tried to stream them to the PS3 connected via wireless, and they play back without any problem with Tversity. So I know the wireless bandwith is enough to handle these files.
Why would transcoding work okay, but straight streaming not?
Not a big issue, I have workarounds, but any help is appreciated! Thanks!


text:
lay 1
verb (past and past participle laid /leɪd/)
- Chuckling, I scooped them up in the palm of my hand and laid them gently on top of a soft pile of Green Stamps and bore them so to London town.
- He scoops up a selection of the sliced eggplant and limps over to the grill on his stovetop, where he carefully lays them to cook alongside the red and yellow peppers.
- Colt lays his hand gently on her shoulder in solidarity.
- There was a thunder storm here this morning, and I was hoping that the rain might lay the pollen and dust a bit.
- The rain the day before cooled the air and laid the dust.
- The light rain has laid the dust and little is lifted by your wheels as you drive.
- My flat is progressing too, with the bulk of the decorating work likely to be finished this week, and new (cheap and cheerful) carpet to be laid on Wednesday.
- The Red Carpet was especially laid for the guests who really enjoyed their stay there.
- In addition the ventilation system is being improved, seats have been re-covered and new carpets are being laid.
- No expense had been spared in the ballroom itself, where the tables had been laid for a lavish banquet.
- The Green Room features a table laid ready for a meal.
- I remember looking into one and seeing a little dining table laid out with tiny silver cutlery.
- As well as the existing handrails, the slopes are also being laid with a non-slip surface.
- In recent years, the surface has been laid with sand and loam.
- Modern display units feature large sliding trays laid with tiles, enabling customers to envisage a whole floor.
- Every one of the 400 bedrooms had a coal fire, laid by the staff each day.
- The girl closed the door, lit lamps and a fire that was already laid, then shuttered the only window of the one room cottage, as if wanting privacy.
- A fire has been laid for us in the parlour and I am certain we have much to discuss.
- She had some sort of trap laid and she was preparing to spring it on him.
- By now, the immediate surroundings were quiet, most of the troops had mustered at the south side of camp in preparation to spring the trap that had been laid.
- He laid a 'glue trap' by the hole at the back of my kitchen cupboard.
- French security sources said that advanced plans had been laid to use a stolen truck or a helicopter loaded with explosives.
- Plans had also been laid to raise more then £1 million locally.
- Plans are being laid to turn the clock back 60 years across large swathes of the resort for three days in early September.
- We are instructed by the above-named prosecutor, and wish to lay the following information before the court.
- But several requests to lay proposals before the bank met with no serious response except that the bank should simply lend more money.
- He lays the evidence before us, without comment, so that we may draw our own conclusions.
- Something funny is going on here… I'd lay all my money on a bet that it was the Emperor who sent that spell to kill me.
- But despite taking $25,000 bets before, she will be content with laying a more modest wager.
- The money was duly laid down, so Lucas whipped off his kit and plunged in.
- Yet not all the blame can be laid at the feet of the activists, because it was the very nature of the government's debate process that encouraged them to act as they did.
- Much blame can be laid on the corrupt and profit-ravenous food industry that shovels false information and dreadful products down our throats all day long.
- The blame here cannot be laid on some interagency squabble between, say, the State Department and the Pentagon.
- The female wasp lays her eggs inside the developing medfly egg.
- A female butterfly lays an egg that looks like a miniature pearl, or a squashed golf ball, or a whiskey barrel.
- Female flies lay eggs every two or three days, 300 eggs each time, which means the number of flies will rocket if not controlled.
- I had just arrived in the park to do some hedge laying.
- He was particularly skilled at draining with hand tools and either laying or cutting thorn hedges.
- The ancient art of hedge laying is alive and well thanks to a lone Preston craftsman, plying his trade around the area's villages.
- Not doing more than getting the lay of the land, but they were there.
- As they say, there is safety in numbers, so if you're in an unfamiliar place, stay with a group, at least until you know the lay of the land.
- Let's take a look at some satellite imagery, give you a sense of the lay of the land of where those pictures are coming from.
- Both male and female breeders are subject to a restricted feeding regime for their first few weeks of life - about 20 days to the point of lay.
The verb lay means, broadly, 'put something down', as in they are going to lay the carpet. The past tense and the past participle of this verb is laid, as in they laid the groundwork or she had laid careful plans. The verb lie, on the other hand, means 'be in a horizontal position to rest', as in why don't you lie on the floor? The past tense of this verb is lay ( he lay on the floor) and the past participle is lain ( she had lain on the bed for hours). Thus, in correct use, lay can be either the past tense of lie or the base form of lay. In practice many people make the mistake of using lay, laying, and laid as if they meant lie, lying, lay, and lain. Examples of incorrect use: why don't you lay on the bed? (correct form is lie); she was laying on the bed (correct form is lying); he had laid on the floor for hours (correct form is lain).
get laid
- informal Have sex.Example sentences
- He was keeping himself busy with his life's work - trying and failing to get laid.
- He had a Playboy duvet cover and still got laid!
- I don't go out to get laid - I go out to have fun.
in lay
- (Of a hen) laying eggs regularly.Example sentences
- Velogenic viral infection of chickens and turkeys in lay usually reveal egg yolk in the abdominal cavity with flaccid, degenerative follicles.
- When she is in lay, she lays an egg a day - usually in the morning.
- Laying chickens produce 265-280 eggs during the 13-14 months they are in lay.
lay something at someone's door
- see door.
lay something bare
- Bring something out of concealment; expose something: the sad tale of failure was laid bareMore example sentences
- Much of its former usages were laid bare for exhibitions.
- The 'chilling' methods used by tobacco companies to market cigarettes were laid bare today as thousands of previously confidential papers were published on the internet.
- It left me exposed, like my heart was laid bare before him.
lay a charge
- Make an accusation: we could lay a charge of gross negligenceMore example sentences
- I didn't think they had sufficient evidence to lay a charge, let alone obtain a conviction and that view hasn't changed after what I've seen today.
- Yet the Children's Bill says 'a male child that was subjected to circumcision against his will may lay a charge of assault'.
- I told him I wanted to lay a charge of assault, and he told me he had two witnesses who would say I had assaulted him.
lay claim to
- Assert that one has a right to (something): four men laid claim to the leadershipMore example sentences
- Four young sisters have laid claim to being Bolton's most musical family after two of them landed places in national orchestras.
- He bravely handled the pressure, stringing four flawless racks to lay claim to victory and the US $75,000 first-place check.
- Japan has laid claim to all the islands seized by Soviet troops at the end of World War II but Russia maintains the issue only involves part of them.
- 6.1Assert that one possesses (a skill or quality): she has never laid claim to medical knowledgeMore example sentences
- In seeking to define himself as Australia's next leader, he lays claim to possessing a key quality he reveres.
- Other religious systems may also lay claim to some of these qualities, but not to the totality of these.
- No, he possesses the real genius that only our greatest comedians can lay claim to.
lay down one's arms (or weapons)
- Cease fighting.Example sentences
- Negotiations cannot convince the militia's leaders to lay down their arms.
- More than 600 attended his funeral in Leytonstone to hear family members appeal to local youngsters to lay down their weapons.
- An estimated 4000 people have reportedly laid down their arms.
lay down the law
- see law.
lay down one's life
- Sacrifice one's life for a cause: the willingness of British troops to lay down their lives for their country is a humbling thoughtMore example sentences
- I do not mean to belittle the heroic deeds achieved by the pioneers, some whom even laid down their lives in fighting crime.
- The scripture in the Bible says no greater love hath no man than a man who lays down his life for his friends.
- Now I find myself mother to five beautiful, intelligent, creative children for whom I would lay down my life in an instant.
lay eyes on
- see eye.
lay a (or the) ghost
- Exorcise a ghost.Example sentences
- Mick said there were stories of various attempts to lay the ghost.
- And perhaps some form of exorcism or " laying the ghost ".
- 11.1Finally cease to be troubled by the memory of an unpleasant situation or event: by claiming victory, they laid to rest the ghosts of five previous defeatsMore example sentences
- The army prided itself in re-establishing its deterrence over Hamas, laying the ghosts of Lebanon in 2006.
- Cougars are out for revenge against Sheffield Eagles on Sunday - to lay the ghosts of last year's nightmare defeats.
- Perhaps incorporating the brand in staffing will lay the ghost to rest.
lay hands on (also lay or put one's hands on)
- I would spend as much time as I possibly could tucked away in different corners of the house reading pretty much anything I could lay my hands on on the subject.
- As soon as I could walk I started to draw on anything with everything I could lay my hands on: walls, furniture, nothing was safe for me.
- In short, your business is far from being destroyed if you manage to lay your hands on this membership.
- It is still used in the ceremony of confirmation, where a bishop, priest, or minister lays hands on the confirmand and prays for them to receive the Holy Spirit.
- He asked for prayer and the brother complied, laying hands on him and asking God to anoint him so that he might lay hands on his friend for healing.
- Only two out of the six churches Ive served since 1981 felt the freedom and the need to lay hands on people and pray for healing.
lay hold of (or on)
- Catch or gain possession of: he was afraid she might vanish if he did not lay hold of herMore example sentences
- But lay hold on this inescapable fact - one day, all death will be abolished.
- This is what the author is clearly reaching out for in this section, but does not fully lay hold of.
- 'In all the districts I visited every opportunity of collecting the folk-lore was laid hold of, and a good deal of it […] was gathered '.
lay it on the line
- see line1.
lay someone low
- (Of an illness) reduce someone to inactivity: he was laid low by a stomach bugMore example sentences
- Rain, thunder and lightning of epic proportions have not succeeded in cleaning the air and we are laid low with massive headaches, blocked sinuses and pervasive brain fog.
- However, Dove has been laid low by a virus all week and his chances of being involved at the weekend are 50-50.
- I am sure producers and TV executives everywhere were sorry to hear that Jon had been laid low by pneumonia before Christmas and like me wished him a speedy recovery.
- 15.1Bring to an end the high position or good fortune formerly enjoyed by someone: she reflected on how quickly fate can lay a person lowMore example sentences
- That's also the premise which lays them low - most people don't have the time to do overly intensive data entry.
- Should he make that connection, he would be perfectly within his rights to lay you low for looking for information that is none of your business.
- He is the archenemy to the Order and has vowed to lay them low one way or another.
lay something on the table
- see table.
lay something on thick (or with a trowel)
- informal Grossly exaggerate or overemphasize something: the message is laid on with a trowel for three hoursMore example sentences
exaggerate, stretch the truth, overdo it, overstate one's case, embellish the truth;flatter, pay extravagant compliments, give fulsome praise, over-praise, soft-soapinformal pile it on, lay it on with a trowel/shovel, ham it up, sweet-talk
- There was some speculation that he might simply be laying the melodrama on thick for the benefit of the crowd, but I don't see it.
- Before she started publishing her guidebooks, the words in most botanical tomes were laid on with a trowel, leaving no room for illustrations.
- Occasionally, the tone can be too sentimental and some of the historic background is laid on with a trowel, but these are quibbles.
lay someone open to
- Expose someone to the risk of (something): his position could lay him open to accusations of favouritismMore example sentences
- The public must realise all surgical procedures carry risks and having plastic surgery lays them open to all of these.
- Privacy campaigners say the system lays you open to permanent surveillance.
- If asked I would certainly refuse to rub down women because it lays you open to allegations of assault.
lay oneself out to do something
- chiefly British Make a special effort to do something: she's laying herself out to be pleasantMore example sentences
- If you start talking about power, you're really laying yourself out to be challenged on just how powerful you are, so people never do it unless they're pretty sure of their ground.
- Look round the circle in which your lot is cast, and lay yourself out to be useful.
- I had to get work, and I laid myself out to get it.
lay siege to
- see siege.
lay store by
- see store.
lay someone/thing to rest
- Bury a body in a grave: they couldn't lay him to rest as his body was never discoveredMore example sentences
- Four years after he was laid to rest his grave was re-opened so they could bury another child in with him.
- When Augustus the Strong died his body was laid to rest in the crypt of Krakow cathedral but his heart was buried in Hofkirche.
- As his body was laid to rest, six Royal Marines fired a volley of three shots followed by a rendering of the Last Post by a bugler.
- 22.1Soothe and dispel fear, anxiety, etc. suspicion will be laid to rest by fact rather than hearsayMore example sentences
- When he caught sight of who had assaulted him, however, his fears were laid to rest.
- If they opened their minds and hearts they would know how silly that is and their fears could be laid to rest.
- I received a call from the manager at 10: 00 a.m. the next morning saying they had found my credit card and my worst fears were laid to rest.
lay something (to) waste
- see waste.
Phrasal verbs
lay about British
- Beat or attack (someone) violently: they weren't against laying about you with sticks and stonesMore example sentences
- The guards laid about them, striking men and women with the flats of their swords.
- Dancers, casting aside their cloaks, revealed themselves as lightly armored fighters who drew all manner of weapons and began laying about them with a will.
- They laid about him with the back of their axes and overwhelmed him with stones and (thigh) bones and ox heads.
- (lay about one)1.1 Strike out wildly on all sides: the mare laid about her with her front legs and teethMore example sentences
- Behave churlishly and rudely, treating everyone you encounter like some kind of moron and generally laying about you with a riding crop.
- Mary alone attempted to resist by force the intrusion of these soldiers, laying about her with a parasol to fend off the men trying to get through the bedroom door.
- I'm getting on a bit myself but I am quite willing and capable of laying about myself with a stick if need be.
lay something aside
- Put something to one side: he laid aside his book figurative the situation gave them a good reason to lay aside their differencesMore example sentences
archaic forsakedefer, shelve, hold over, suspend, put on ice, mothball, set aside, put off, put aside, put out of one's mind, wave aside, put back, adjourninformal put on the back burner, put in cold storagerare remit
- If ethnic differences are laid aside, it is likely the issue of religious observance that will keep Afghanistan's rulers busy for some time to come.
- By the time we lay the book aside, we have witnessed an extraordinary reversal.
- After and only after both players have picked, they may take pairs of cards of the same rank from their hands and lay them aside to count toward their score.
- 2.1Reserve money for the future or for a particular cause: he begged them to lay something aside towards the causeMore example sentences
put aside, put to one side, keep, save, store, hold in abeyance
- For homeowners it means paying off the mortgage slower, or reducing their ability to lay money aside for retirement.
- Prompt treatment is vital for the well-being of your pets, so ensure you can afford to lay money aside for contingencies such as these.
- She has laid aside a little sum, but her long expensive illness takes her last dollar.
lay something down
- The block was built around the four sides of a concrete courtyard which he had laid down.
- She laid down on the cot, pulling a tattered blanket over herself.
- He walked up to her desk and laid a file down.
- School rules are not laid down so that teachers can get a kick out of enforcing them.
- The rules are laid down for signing and loaning players and Wanderers work strictly within those rules.
- From the start strict rules were laid down for its romantic novels, toning down passion to avoid offence.
- It's a haven in the wild west of the web; a place where you can lay your money down and be sure that you will get your cash back if the goods do not turn up.
- I've done my bit to help Freddie to make his millions by purchasing his novels as they appeared, so why stop now I said to myself recently as I laid my money down for his latest.
- So I laid the money down, I just had to help him out I'll never forget the look on his face when he said Mama's gonna look so great
- As psychoanalysis has taught us in its methodology of disinterested attention, only after all the tracks have been laid down may one begin to evaluate them.
- The massive naval harbour that bites into Algeciras Bay was a Victorian achievement, that was only properly completed in the 1900's after which the dry docks were laid down.
- Work proceeded forthwith, and the first three of five Holland boats were laid down on February 4, 1901.
- Synorogenic flysch deposits were laid down in front of the advancing allochthonous complexes, and were overridden by them.
- We know that these limestones were laid down in a shallow shelf sea that was periodically exposed as sea levels fell worldwide owing to the build-up of ice in a former glaciation.
- The confusion can be traced to the uniformitarian expectations that the deposits were laid down over eons of time.
- Alternatively, wines can be laid down for just one of these occasions, as required.
- When someone opens a bottle of my wine many years from now they will know that our wines have ageeability and can be laid down (cellared) for decades.
- He believed the white mold actually played an important part of his winemaking process, as it coated nearly everything, from the barrels to the bottles which he laid down there for years.
- How do you feel it's an advantage over laying things down on tape piece by piece?
- It was fact that we went in there and laid it down in six hours that gave the first songs such urgency and energy - just can't be captured again once you lose your innocence!
- But the true power in this album is that she laid the tracks down live and left them that way.
- 4
- Build up a stock of something in case of need: the police are expecting riots and preparing by laying in guns and tear gasMore example sentences
stock up with/on, stockpile, store (up), amass, heap up, hoard, save, stow, put aside, garner, accumulate, pile up, mass, assemble, stack up, put away, stow away, husband, reserve, preserve, conserve, collect, muster, put by, put by for a rainy day, squirrel awayinformal salt away, stash (away)
- By hard work and thrift he managed to lay up considerable of this world's goods and at the time of his death was in comfortable circumstances.
- During this time his expenses had swallowed up the small amount which he had succeeded in laying up previous to his sickness.
- Unless you have the foresight to lay up stores in advance, production will grind to a halt.
lay into
- informal Attack violently with words or blows: three youths laid into himMore example sentences
attack, assail, hit, strike, let fly at, tear into, lash out at, set about, set upon, fall on, turn on, assault, beat, thrash, pound, pummel, wallop, hammer, pounce on, round on, pelt, drubinformal lace into, sail into, pitch into, let someone have it, get stuck into, paste, do over, knock about/around, rough upBritish informal have a go atinformal pitch into, crucify, rubbish, slag offBritish informal have a go atNorth American informal light into, bad-mouth, bawl outrare objurgate
- After seeing the error of their comrades, the three armed men advanced more cautiously towards Erik, attempting to surround him first before they laid into their attack.
- He was astounded when the journalist unexpectedly exploded into violence, laying into a passer-by larking about for the camera.
- She laid into the companies that pitched for funds on the programme, saying she had only gone on the show to promote her business.
lay off
- informal Give up or stop doing something: I laid off smoking for seven yearsMore example sentences
give up, stop, refrain from, abstain from, not continue, desist from, leave alone, cut out;North American quit
- In her defense, laying off the booze would mean seeing him sober…
- Now I'm doing an Amber and trying to quit the fags - my immune system is shot and laying off the smokes should help a bit.
- Im also trying to lay off the dairy after a week of upset stomach.
- 7
- Discharge a worker temporarily or permanently because of a shortage of work: the company has laid off 30 per cent of its staffMore example sentences
informal sack, give someone the sack, fire, give someone their cards, give someone their marching orders, send packing, give someone the boot, give someone the bullet, give someone the push, give someone the (old) heave-ho, boot out
- This isn't the first time (and unlikely to be the last), but a group of striking workers in Korea have been laid off by text message by their employer.
- Nonetheless, her co-workers at the hotel told her that the next day two new workers were hired to do the same job she had been laid off from.
- His wife, a former textile worker, took care of him and his son when he was laid off from his factory.
lay something off
- No forward likes to have someone on top of them, they just end up laying the ball off with passes.
- He lays the ball off to Heskey, who drives a useless cross against the legs of the nearest Swedish defender.
- They passed to each other, they ran past each other, they laid the ball off to each other.
- When you get good at this, you can quickly reverse each consecutive pass to lay the paint off in one direction.
- When it comes to laying the paint off to ensure no brush marks are left behind I always use the following analogy when training people to paint
- After applying by roller, laying off the paint with a brush or pad will give you an improved finish.
- Any sensible fella would have laid the bet off by now, guaranteeing him a fair wedge.
- Even then you had to wait whilst he phoned and laid the bet off before they accepted it.
- This scenario will happen to you and the trick is to accept it, lay the bet off and accept a small loss and then move onto your next trade.
lay something on
- Replacement bus services were laid on for rail passengers unable to travel over the weekend.
- Alternate bus routes have been laid on until normal service is resumed.
- Tickets will be on sale during the week and a bus service will be laid on from the village to the hall and home again that night.
- And that's one thing - when the administration tries to lay this responsibility on the military to make the decision - that's not who makes the decision to go to war.
- He says it is not fair to lay the entire responsibility on the group, since others may have been involved.
- She explains that American women are fortunate because our culture values the family and lays responsibilities on men so women can safely have children.
lay someone out
- It was later confirmed that Kennedy was laid out in the East Room prior to his burial in Arlington.
- The design comes into its own in the final scene, when Lear and Cordelia are laid out together, finally united in death.
- The walls of his log cabin-style burial chamber were draped in fabric, and he was laid out on a decorated bronze couch covered with furs and other material.
- If your brother knew what we did he'd lay me out with one punch.
- The Major was laid out on the floor and a man in a white coat immediately bent over her.
lay something out
- If you were to uncoil a French horn and lay it out to its full length, it would be over six miles long.
- Carefully holding them he made his way back to the couch and laid the contents out on the coffee table.
- 'Thank you so, so much,' I whispered, laying the dress out on the gown and hugging my aunt tightly.
- The area where the houses and gardens would be laid out would be raised by about 2ft to counter the risk of flooding and changes to the drainage at the edge of the reserve.
- These gardens were laid out in 1550 for the Medici a year after they bought the Palazzo Pitti and were opened to the public in 1766.
- The gardens had been laid out quite formally, but there are signs of obvious neglect.
- The final feed would end up in the production department, where the text would be laid out and made ready for actual printing.
- What I liked was that the material is laid out in a reasonable fashion.
- The lines are laid out as prose, although there are a few attempts at verse format on the early pages, and sentences run on without a break.
- You have to lay it out for her, explain that her behaviour will end your relationship.
- I liked the fact that he laid it out very clearly that we're going to be OK, but we're going to go after these guys.
- Any scientific theory has an exemplary case where the basic ideas and methodologies are laid out clearly and convincingly.
- Similarly in Sligo we will never know how much money is laid out, and at the end of the day it is the ordinary 'Joe Soap' that goes around begging to raise money for the County Board.
- If the latter, then we have to wonder if consumers will be willing to lay out good money to see something they've already bought fixed properly.
- But when we come in, the cheaper it is, the better for us, because we know we're not going to have to lay out so much money.
lay over
- US Break one's journey: Steven and I will lay over in New York, then fly to LondonMore example sentences
- August 1-2: The party runs a short distance on the river and then lays over for a day to rest and explore.
- This is a short video showing passengers boarding a low floor trolleybus while it lays over at its city centre terminus in Basle, Switzerland.
- On the return portion of my Turkey trip I will be laid over in Istanbul until the next morning.
lay up
- Golf Hit the ball deliberately to a lesser distance than possible, typically in order to avoid a hazard: the conservative thing to do was lay up and settle for a fiveMore example sentences
- In fact, I laid up on every par 5 but still made a birdie each time.
- I debated with my caddie, Stevie, about laying up.
- I hit my drive in the fairway, laid up with a 7-iron, then hit a wedge to the back fringe.
lay someone up
- Put someone out of action through illness or injury: he was laid up with the fluMore example sentences
bedridden, ill in bed, confined to bed, on the sick list, out of action/commission, housebound, immobilized, incapacitated, injured, disabled;
- The injury that laid him up for so long, and caused him to wreak revenge was self-inflicted, a result of that desperate lunge.
- My Uncle was laid up with an arthritic problem, but from his couch or hobbling about he would carry on renovation to his house.
- Her many friends are so sorry to hear she is laid up and we all wish her a speedy recovery.
lay something up
- By the time the boat owner contacted the state, his boat had been laid up for three months, waiting for simple repairs to be completed.
- Buying a boat outright in Michigan means that a person bears the full cost of the six months that the boat is laid up for the winter instead of a fraction of the cost under boat sharing.
- Formerly HMS Upholder, she was the first of the four boats launched between 1986 and 1991, but by 1994 they had been laid up, with no role to play as the Cold War was over.
- Simply put, fiberglass materials and core materials are laid up without any resin.
- But the front wing had complex curves that could cause unexpected shifts in plies as they were laid up, resulting in weak spots.
- Board and batten patterns are laid up using standard dimension lumber.
Words that rhyme with layaffray, agley, aka, allay, Angers, A-OK, appellation contrôlée, array, assay, astray, au fait, auto-da-fé, away, aweigh, aye, bay, belay, betray, bey, Bombay, Bordet, boulevardier, bouquet, brae, bray, café au lait, Carné, cassoulet, Cathay, chassé, chevet, chez, chiné, clay, convey, Cray, crème brûlée, crudités, cuvée, cy-pres, day, decay, deejay, dégagé, distinguée, downplay, dray, Dufay, Dushanbe, eh, embay, engagé, essay, everyday, faraway, fay, fey, flay, fray, Frey, fromage frais, gainsay, Gaye, Genet, giclee, gilet, glissé, gray, grey, halfway, hay, heigh, hey, hooray, Hubei, Hué, hurray, inveigh, jay, jeunesse dorée, José, Kay, Kaye, Klee, Kray, Lae, lei, Littré, Lough Neagh, lwei, Mae, maguey, Malay, Mallarmé, Mandalay, Marseilles, may, midday, midway, mislay, misplay, Monterrey, Na-Dene, nay, né, née, neigh, Ney, noway, obey, O'Dea, okay, olé, outlay, outplay, outstay, outweigh, oyez, part-way, pay, Pei, per se, pince-nez, play, portray, pray, prey, purvey, qua, Quai d'Orsay, Rae, rangé, ray, re, reflet, relevé, roman-à-clef, Santa Fé, say, sei, Shar Pei, shay, slay, sleigh, sley, spae, spay, Spey, splay, spray, stay, straightaway, straightway, strathspey, stray, Sui, survey, sway, Taipei, Tay, they, today, tokay, Torbay, Tournai, trait, tray, trey, two-way, ukiyo-e, underlay, way, waylay, Wei, weigh, wey, Whangarei, whey, yea
For editors and proofreaders
Line breaks: lay
lay 2
- Modern scholarship has done much to rescue the pastoral reputation and moral seriousness of the clergy and their lay supporters at all levels.
- She was training to be a lay preacher, but knew that wasn't where she wanted to be, and wasn't sure where she was going.
- During this time Bethel has been well supported by ministers from the South Wales area, some of them retired, and by lay preachers from the locality.
- Often faculty are not clinicians but other health professionals and lay community members.
- Newspapers are an important source of information about the results of medical research, both for lay people and health professionals.
- Like lay rules, most professional rules are tacit and informal and are never formally articulated.
Middle English: from Old French lai, via late Latin from Greek laïkos, from laos 'people'. Compare with laic.
For editors and proofreaders
Line breaks: lay
lay 3
- James Macpherson based his Ossianic pieces on these lays.
- We come to the lay's treatment of the third type: the woman, as represented by the wife.
- In no other of Marie's lays is the roster of personages so heavily weighted toward a single gender.
Middle English: from Old French lai, corresponding to Provençal lais, of unknown origin.
For editors and proofreaders
Line breaks: lay
lay 4
For editors and proofreaders
Line breaks: lay
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.


text:
All About Myelofibrosis
What is myelofibrosis?
Myelofibrosis is a rare cancer of the bone marrow in which the marrow is replaced by scar tissue and is not able to make healthy blood cells. It is classified as a type of chronic leukemia and belongs to a group of blood disorders called myeloproliferative diseases. It may also be called primary myelofibrosis, chronic idiopathic myelofibrosis or myelosclerosis with myeloid metaplasia.
A myeloproliferative disorder is a disease in which the bone marrow produces either too many or too few of certain blood cells, most of which do not function properly (each disorder's name comes from the cells that are affected). This group of diseases also includes chronic myelogenous leukemia, polycythemia vera (PV), essential thrombocythemia (ET), chronic neutrophillic leukemia and chronic eosinophillic leukemia. PV and ET can progress to myelofibrosis and account for 10-15% of myelofibrosis cases. Myelofibrosis can progress to other, more aggressive, types of leukemia. The disease can have a variable prognosis with some patients living decades while others progress to more aggressive forms with survival times less than 2 years.
How are normal blood cells produced?
In order to understand myelofibrosis, it is helpful to understand how normal bone marrow functions. The bone marrow is a spongy area in the center of our bones. Its role is to produce blood cells.
- White blood cells (also called leukocytes) are the body's infection fighting cells.
- Red blood cells (also called erythrocytes) give blood its red color, but more importantly, carry oxygen from the lungs to the rest of the body and return carbon dioxide to the lungs as waste.
- Platelets (also called thrombocytes) help the body form blood clots to control bleeding.
Larger bones have more bone marrow, and therefore produce more blood cells. The larger bones include the femur (top part of the leg or thigh), the hip bones, and parts of the rib cage. The bone marrow contains hematopoietic stem cells (or blood stem cells), which are cells that can produce one type of blood cell over and over again. It also contains a small percentage of cells that are in development and are not yet mature. These immature cells are called blasts. Once the cell has matured, it moves out of the bone marrow and into the circulating blood. The body has mechanisms to know when more cells are needed and has the ability to produce them in an orderly fashion.
In the case of myelofibrosis, one blood stem cell acquires the ability to reproduce without regulation, producing large numbers of immature blood cells. When looked at under a microscope, these abnormally produced cells look different then the healthy cells and do not function properly. The body continues to produce these abnormal, non-functional cells, leaving little space for healthy cells. At the same time, these cells release chemicals that cause the bone marrow to become "fibrous" or fill with scar tissue, further interfering with the ability to produce healthy blood cells. In addition, these abnormal cells may be produced in other areas of the body, most often the spleen or liver, which results in an enlarged spleen or liver that can be felt by the physician.
Am I at risk for myelofibrosis?
Myelofibrosis is a rare diagnosis, though the exact incidence is not known. It is likely underestimated as less severe and/or asymptomatic disease may go undetected. However, estimates suggest the annual incidence in the United States population to range from 0.3 to 1.5 cases per 100,000 persons.
Aging is the major risk factor for developing myelofibrosis, as the disorder usually develops in people over age 50, with the average age at the time of diagnosis being about 60 years old. About 15% of all patients diagnosed with myelofibrosis are under the age of 50 and about 6% under 40. There are no other known risk factors.
Myelofibrosis primarily develops without a known cause (called primary myelofibrosis);however, other myeloproliferative diseases can progress into myelofibrosis. Ten to fifteen percent of myelofibrosis cases have developed from a diagnosis of polycythemia vera or essential thrombocythemia (called secondary myelofibrosis). Though some families have a predisposition for the disease, it is not passed on or inherited. The disease appears to be caused by a change in a gene that occurs during a person's lifetime. Perhaps this change is due to exposure to something in our environment (which family members may have in common).
Currently, there is no known intervention to prevent myelofibrosis. Additionally, there is no screening test for the disease. There is not a specific test for myelofibrosis, however, routine blood work can be used as a screen to check the red and white blood cell counts as well as the platelet count. These tests can prompt further, more invasive testing, such as a bone marrow biopsy.
What are the symptoms associated with myelofibrosis?
About one third of individuals with myelofibrosis have no symptoms, which can make the disease difficult to detect. As the number of abnormal cells increase and healthy cells decrease, symptoms tend to develop, most often related to a low red blood cell count (anemia) or enlarged spleen. Anemia commonly presents as paleness, generalized fatigue, and shortness of breath during activity. Approximately 50-70% of patients report fatigue at the time of diagnosis. People may also develop chest pain or dizziness as the heart has to work harder to get adequate oxygen to the brain and other organs when the red blood cell count is low. A minority of patients report "constitutional symptoms", which include weight loss, low-grade fever, and night sweats. Many patients will also experience intense itching, known as pruritis, secondary to generalized inflammation.
Severe anemia, easy bruising or bleeding and multiple infections can result because of the lack of healthy blood cells. An enlarged spleen (splenomegaly) and/or liver (hepatomegaly) may also occur. When the bone marrow scars, the liver and spleen try to make blood cells to compensate (called extramedullary hematopoiesis), causing these organs to swell. Approximately 25-50% of patients will have symptoms from an enlarged spleen at diagnosis, including pain with deep breaths, loss of appetite and feeling full after eating a small amount (early satiety). Extramedullary hematopoiesis can also occur in other parts of the body (lymph nodes, spinal cord, lungs), causing swelling in these areas, leading to symptoms.
How is myelofibrosis diagnosed?
The World Health Organization (WHO) has developed the following criteria for the diagnosis of myelofibrosis. A patient must meet all 3 major criteria as well as 2 minor criteria for a diagnosis of primary myelofibrosis.
Major criteria:
- Presence of megakaryocyte abnormalities (precursors cells to platelets) accompanied by fibrosis in the marrow.
- Not meeting the diagnostic criteria for polycythemia vera, chronic myeloid leukemia, myelodysplastic syndrome, or other leukemic diseases.
- Demonstration of a gene mutation (JAK2 and MPL); or, in the absence of a mutation, no evidence that bone marrow fibrosis is caused by an underlying inflammatory disease or another neoplastic disease.
Minor criteria:
- Enlarged spleen that can be felt.
- Anemia.
- Increased Lactate Dehydrogenase (LDH) levels.
- Leukoerythroblastosis- Anemia caused by scarring in bone marrow that leads to immature blood cells in the blood.
Tests Used for Diagnosing Myelofibrosis
Complete Blood Count (CBC)
CBC is the most common blood test. It uses a machine to evaluate the number of red blood cells, platelets, and white blood cells circulating in the blood. The amount of hemoglobin, the substance which carries oxygen in red blood cells, is also assessed on a CBC. A low red blood cell count is known as anemia, which is common in this disease. Additionally, the platelet counts and white blood cells counts can either be elevated or low.
Peripheral Blood Smear
A small sample of blood can be smeared on a slide and examined under a microscope to count cells by hand as well as examine them for defects.
The body's normal response to anemia is to form new blood cells. Because this occurs poorly in myelofibrosis, immature blood cells are seen in the circulating blood. This is known as leukoerythroblastosis. Red blood cells frequently appear abnormal in myelofibrosis on a peripheral smear with unusual shapes and sizes, reflecting defective production of the red blood cells.
Defects in the appearance of the platelets and white blood cells can also be seen on a peripheral smear. Similar to red blood cells, immature platelets and white blood cells may be seen on a blood smear.
Bone Marrow Biopsy
A bone marrow biopsy is required for the diagnosis of myelofibrosis. Generally, this involves local anesthetic being injected into the buttock region and a small core of bone marrow taken out using a needle. A bone marrow aspiration, which is less invasive, is frequently unsuccessful because of the scarring. The scarring will cause the aspiration to be "dry."
In myelofibrosis, the bone marrow typically finds fibrosis, or scarring, of the marrow. Hyperplasia, which is an increase in the precursor cells (the cells that develop into mature red & white blood cells and platelets), is nearly always seen. This increase in precursor cells can be in one or multiple cell lines. For example an increase in the number of megakaryocytes, which will go on to form platelets in the blood, is known as megakaryocyte hyperplasia. These megakaryocytes may also appear abnormal under the microscope. Increased (thrombocytosis) or decreased (thrombocytopenia) platelets can be seen in the peripheral blood of individuals as well.
Molecular Testing
In 2005, it was discovered that many patients with myelofibrosis have a gene mutation that can be detected with testing. The most common mutation, occurring in 50-60% of cases, is found in the JAK2 (Janus Kinase 2) gene. This gene is important to the system our body uses to signal the need for more blood cells. When the "JAK2V617F" mutation is present, the gene can no longer say "stop making cells", causing the overgrowth of immature, non-functional cells.
For another 5-10% of patients, the abnormality is found in the MPL gene, which is also involved in the pathway that signals for more blood cells to be produced.
What are the prognosis and treatments for myelofibrosis?
The median survival of all patients with myelofibrosis is slightly higher than 5 years. Because survival times range from decades to less than 2 years, it was necessary to create a scoring system to assist physicians in making informed decisions regarding prognosis and treatment options. The most widely used classification system is the International Prognosis Score System (IPSS). The IPSS assigns a point value based on various abnormalities. These points are added up to calculate a score specific to each person. This score can be used as a measure of the aggressiveness of the disease. Each of the following indicators of aggressive disease are given 1 point in the IPSS:
- Hemoglobin less than 10 g/dl.
- Older age (>64 y/o)
- Presence of constitutional symptoms (including weight loss, night sweats, low-grade fevers).
- Highly abnormal white blood cell counts (<4,000 or >25,000 cells/ mL).
- Blast cells (immature cells) seen in the peripheral blood, greater than 1%.
- Very low platelet counts (<1000,000 cell/mL).
These are tallied to achieve a score, which corresponds to a risk group – low risk (score 0), intermediate 1 (score 1), intermediate 2 (score 2), high risk (score ≥3). Other scoring systems include the Dynamic IPSS and the Dynamic IPSS Plus, which incorporate the need for transfusion of red blood cells as well as unfavorable genetic changes. Additionally, the age at diagnosis and how generally healthy the person is at the time of diagnosis are critical when selecting a therapy. Median survival is up to 15 years for low risk disease (less than 1 risk factor) versus 2-3 years for patients with high risk disease (3 or more adverse features).
Because there are very few curative options for myelofibrosis, most therapies are aimed at minimizing symptoms. Many patients do not meet criteria for aggressive therapies, and treatment is focused on palliation with primary goals of limiting the symptoms associated with the decreased blood counts, improving quality of life, and decreasing the risk of progression to acute leukemia. Generally speaking, patients that are not candidates for stem cell transplant (see below) and do not have symptoms are not treated until symptoms develop. Selecting the appropriate treatment for a patient is very important and a number of studies have demonstrated ways to determine which treatment is appropriate for a given person.
Targeted Therapies
The discovery of JAK2 mutations in 2005 opened the door to development of a targeted therapy for people with myelofibrosis. Following this discovery, several clinical trials began, hoping to take advantage of the mutation and develop a new treatment. Although these agents have proven useful in alleviating symptoms associated with myelofibrosis, none have proven effective as a cure. Collectively, these therapies are known as JAK2 inhibitors.
Ruloxitinib (Brand name- Jakafi) is a JAK2 inhibitor and became the first FDA-approved drug for treating MF patients in 2011. This approval was based on a trial published in the New England Journal of Medicine in 2010, which demonstrated that the drug is well tolerated and led to reductions in symptoms including spleen size, abdominal discomfort, early satiety, bone pain, night sweats and itching. Although Jakafi did not decrease the burden of myelofibrosis in the bone marrow, it did reduce the level of pro-inflammatory cytokines in the blood. It is currently only used in patients with symptomatic intermediate and high risk disease.
Pomalidomide, a new immunomodulator, has also shown some promise. In a study from the Mayo Clinic, it demonstrated improvement in anemia related to myelofibrosis in patients with the JAK2 mutation.
Many medications are the subject of clinical trials for the treatment of myelofibrosis. JAK2 inhibitors continue to be explored in clinical trials. Additionally, immunomodulators, including lenalidomide and thalidomide, appear to have some activity in symptomatic myelofibrosis. mTOR inhibitors, including everolimus, are also currently of interest as well. A trial with everolimus demonstrated improved symptoms in patients with symptomatic high-risk disease. Etanercept, a Tumor Necrosis Factor (TNF) receptor, appears to improve constitutional symptoms in myelofibrosis as well. All of these medications remain under investigation.
Interferon is an immune therapy that works by reducing the overabundance of unhealthy blood cells and reduces the cytokines that lead to fibrosis in the marrow. It appears to work best in those with early myelofibrosis secondary to PV or ET. Interferon has significant side effects that can be difficult to tolerate.
Stem Cell Transplant
Currently, the only curative treatment is allogeneic stem cell transplant (where the bone marrow comes from a donor). Stem cell transplants have risks related to complications. For this reason, they are generally reserved for people in good health, who are younger than 60 and have a "matched" donor. Current guidelines recommend stem cell transplant only in young patients with high risk disease.
Given that most people present with MF at an older age and that MF is a chronic disease, supportive care is extremely important to limit symptoms and maintain a high quality of life. Supportive care treatments include the following:
Hormone therapy
A combination of androgen preparation (fluoxymestrone, Halotestin) and corticosteroids (prednisone) can be used to improve anemia. Exogenous Erythropoietin administration has also been shown to improve anemia in 30-50% of patients.
Hydroxyurea : is a drug that is thought to interfere with the synthesis of DNA and is used in the treatment of other blood disorders. It has been shown to decrease the size of the spleen and help control platelet and WBC counts.
Because the enlarged spleen can be a source of discomfort, its removal can alleviate symptoms. Surgical removal is associated with risks as the spleen has an important role in infection fighting. Indications for splenectomy in patients who continue to have splenomegaly despite drug therapy include thrombocytopenia, frequent red cell transfusions and symptomatic portal hypertension. One study of splenectomy in 314 patients with myelofibrosis found that 75% benefitted from the procedure with resolution of severe thrombocytopenia and becoming transfusion-independent. In this study, the benefit lasted for a median of 1 year. If surgical removal of the spleen is not possible, a short course of radiation therapy to the spleen can be given to transiently improve symptoms.
Further reading
- MPN Education Foundation – educational information & an online support group.
- MPN Research Foundation – educational information
- Tefferi A. Abeloff's Clinical Oncology, 4th edition. In: Chapter 106- Myeloproliferative Disorders. Philadelphia, PA:Elsevier; 2008
- Hoffman R, Ravandi-Kashani F. Hematology: Basic Principles and Practice, 4th edition. In: Chapter 70 - Idiopathic Myelofibrosis. Philadelphia, PA:Elsevier; 2005
- UpToDate: Clinical manifestations and diagnosis of primary myelofibrosis
- Vannucchi AM. Management of Myelofibrosis. Hematology Am Soc Hematol Educ Program. 2011
- Tefferi A. Annual Clinical Updates in Hematological Malignancies: a continuing medical education series: polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management. Am J Hematol. 86:1018-1026, 2011.


text:
- Let your love show
- Currently Unavailable
Andy Carroll has been lauded by some as one of the best forwards in the English Premier League. And standing at a towering 6'3" he's recognized as having one of the best heads on the ball in the league as well.
Show your Liverpool Carroll love with this cool poster.
Lamentamos que todavia no hay descripción en español para este producto.


text:
Automates typing of frequently used text and pictures and auto-corrects typos
Have you ever experienced the frustration of having to repeatedly type your name, e-mail address, and other words or phrases again and again? Do you often misspell words when typing? Typinator boosts your productivity by automating the process of inserting frequently used text and graphics and auto-correcting typos. Drag-and-drop import from Textpander, TextExpander, and TypeIt4Me makes migration to Typinator a no-brainer.
Required OS: not specified
Tags: text , expander , textexpander , expansion , snippets , abbreviation , automatic , software , insert , pictures
12 Opinions
RapidoWrite may be nice, but if you look at their list of unsupported apps it says that they don't support MS Office, Pages, or Firefox (and potentially by extension, other apps which use the Gekko engine, even Camino, even though that's Cocoa-based). That's a huge deal-breaker for me, since I spend most of my typing time in those apps.
What puzzles me is why Pages isn't supported, even though it's Cocoa-based and hence should work with the InputManager-based approach that RapidoWrite takes to do what it does.
Rapidowrite is free! good alternative http://osx.iusethis.com/app/rapidowrite
Page 2 of 2. 12 entries.


text:
Game of Thrones is a site for the HBO-series based on George R.R. Martin's A Song of Ice and Fire.
New to the series? Read our spoiler-free review of A Game of Thrones.
Read our Privacy Policy.
The young, handsome Lord of Blackhaven, one of the castles of the Dornish Marches. Red of hair, he is betrothed to Lady Alia Dayne and has her nephew as his squire.
It's unclear that Edric Dayne will appear on the show. Besides this, Dormer seems to match the character reasonably well, other than being rather older. It should be noted that the role was played by a featured extra in the first season, but was recast for the third season.
The Westeros network consists of several different sites, including a forum and a wiki, for all your A Song of Ice and Fire needs.


text:
Durango resident Michelle Katherine Berard died of cancer Friday, April 13, 2012, in Durango. She was 48.
Miss Berard was born to Robert L. and Mary P. Berard on Dec. 23, 1963, in Stevens Point, Wis. She grew up in Stevens Point.
She moved to Durango to be in the mountains she dearly loved, her family said. She had been living in the southwestern United States and Durango for more than 30 years.
Miss Berard was a massage therapist and life coach. She established and operated her own business, Mountain Sage, in 1998, in Durango.
�She thoroughly enjoyed hiking and exercise, and snow skiing was her passion,� her family said. �Michelle�s close-knit friends were a local ski group, lovingly called �The Posse.� Her presence will be missed and celebrated at Durango Mountain Resort.�
Miss Berard is survived by her siblings Patti Anderson and Bob Berard, both of Stevens Point, Mick Berard of Lake Tomahawk, Wis., MiMi Berard of Wausau, Wis., Peggy Helz of Nashotah, Wis., Sue Ann Berard of West Palm Beach, Fla., Jeanette Goudaillier of Campbell, Calif., and Bill Berard of Edina, Minn.; 11 nieces and nephews; and 10 great-nieces and nephews.
A memorial service will be held at a later date in Durango. A private family memorial service will be held at the Berard summer home in northern Wisconsin at a later date.
Memorial contributions may be sent to the Angel Foundation, 700 S. Third St., Suite 106 W, Minneapolis, MN 55415.


text:
$708.81 available Savings
Energizer Coupons and Printables
2 Energizer offers are available for you.
Save $0.55
Energizer MAX®
on any one (1) pack of Energizer MAX® Brand batteries
See more offers in Household.
Save $0.95
Energizer® Ultimate Lithium
on any ONE (1) Energizer® Ultimate Lithium
See more offers in Household.
You might also like these coupons
Save $1.10
Energizer Recharge®
on any one (1) pack of Energizer Universal or Power Plus Recharge® Brand batteries, AA/AAA or Energizer Charger
See more offers in Household.
Save $0.90
Energizer® EcoAdvanced®
on any one (1) pack of Energizer® EcoAdvanced® Brand batteries
See more offers in Household.
Related Online Stores
Popular Categories
Loading Page 2
SuperSaver Newsletter
Never miss another great coupon. Save like a couponista with weekly saving alerts and new offers delivered right to your inbox.
Coupons.com Mobile App
Save time and money. Find coupons and codes for stores you love while you shop in store or online. Coupons.com app is available on iOS and Android.Get App
Coupon Codes
Shop online with coupon codes from top retailers. Get Sears coupons, Best Buy coupons, and enjoy great savings with a Nordstrom promo code.Shop Now
About Us
Find out more about how Coupons.com helps brands and retailers engage consumers with our portfolio of digital, social & mobile solutions.See Details