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PI Name: Wu
Project Title: Diet, Genetic Factors, and the Gut Microbiome in Crohn's Disease
Abstract: DESCRIPTION: We propose to investigate the hypothesis that consistent changes in the human gut microbiome are associated with Crohn's disease, a form of inflammatory bowel disease, and that altered microbiota contributes to pathogenesis. Analysis of this problem is greatly complicated by the fact that multiple factors influence the composition of the gut microbiota, including diet, host genotype, and disease state. For example, data from others and us document a drastic impact of diet on the composition of the gut microbiome. No amount of sequencing will yield a useful picture of the role of the microbiota in disease if samples are confounded with uncontrolled variables. Our proposed project will take advantage of our experience with deep sequencing to characterize the composition of the gut microbiome, but also control diet, host genotype, and disease state. Diet will be controlled by analyzing children treated for Crohn's disease by placing them on a standardized elemental diet, and by testing effects of different diets on the gut microbiome composition in adult volunteers. Genotype will be analyzed by large scale SNP genotyping, which is already underway and separately funded team member Hokan Hakonarson is currently genotyping 50 children a week at ~half a million loci each and investigating connections with inflammatory bowel disease. Clinical status will be ascertained in the very large IBD practice in the UPenn/CHOP hospital system. Effects of diet, host genotype, and disease state on the gut microbiome will be summarized in a multivariate model, allowing connections between microbiome and disease to be assessed free of confounding factors. PUBLIC HEALTH RELEVANCE: The bacteria present in the intestinal tract, known as the gut microbiome, probably play a role in the pathogenesis of Crohn's disease, but the mechanism remains unclear. In this study, we propose to determine the composition of the gut microbiome associated with Crohn's disease while controlling for confounding factors known to alter the gut microbiome, such as host genetics and diet. These studies will provide a clearer vision of the types of bacteria associated with Crohn's disease and provide new insights into pathogenic mechanisms and potential therapy.
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Sarasota area No. 10 in nation for financial distress
Published: Thursday, February 14, 2013 at 1:00 a.m.
Last Modified: Wednesday, February 13, 2013 at 7:38 p.m.
Consumers in Sarasota and Bradenton are among the most financially distressed in the nation, a new report finds, despite a strong upswing in jobs and improved household budgeting.
Metropolitan statistical areaFourth-quarter index score
1. Orlando-Kissimmee-Sanford61.91
2. Las Vegas62.66
3. Tampa Bay62.67
4. Riverside-San Bernardino-Ontario, Calif.63.11
5. Fresno, Calif.64.16
6. Bakersfield-Delano, Calif.64.47
7. McAllen-Edinburg-Mission, Texas64.84
8. Jacksonville65.34
9. Miami-Fort Lauderdale65.54
10. North Port-Bradenton-Sarasota65.67
SOURCE: CredAbility Consumer Distress Index
Greater Sarasota was one of five metropolitan areas in Florida listed among the country's weakest 10 markets for financial health in the fourth quarter, according to an index released Wednesday.
Orlando was ranked as the nation's most financially feeble city, followed by Las Vegas and the Tampa Bay area -- all with scores below 63 on a 100-point scale.
Southwest Florida was not far down on the list, at No 10. The North Port-Bradenton-Sarasota area scored a 65.7 on the index, according to CredAbility, a nonprofit credit counseling and education agency.
"There's still some struggles in the housing market, and we still have some issues with the financial crisis," said Gary Jackson, economics professor at Florida Gulf Coast University and director of the school's Regional Economic Research Institute.
"These areas were hit hard. We have made substantial progress, but the general feeling is it will take another a couple years to get things really back," he added.
Sarasota-Bradenton-North Port's score, however, was nonetheless up three points from the previous quarter and more than five points over the same period in 2011.
While scores under 70 indicate consumers are still in distress, the Sarasota-Bradenton area is making better progress than nearby communities. By comparison, Tampa rose two points for the quarter and 4.3 points for all of 2012, while Orlando rose two points for the quarter and 4.6 points for the year.
CredAbility tracks the financial condition of U.S. households quarterly by measuring five categories: employment, housing, credit, how families manage household budgets and net worth.
Sarasota rebounded in most of the categories that measure financial health, but poor home equity and bruised credit dragged it down.
Some economists were surprised with Sarasota's place on the list.
"Things seem to be improving quicker in areas like Sarasota and Naples because of the population influx and the rebound in asset valuations," said Sean Snaith, an economist with the University of Central Florida. "I would not have placed Sarasota in the same pot as Orlando in terms of distress."
Florida as a whole was the nation's ninth most financially distressed state, with Nevada sitting atop the list. The Sunshine State posted a score of 68.60 -- an improvement from both the third quarter and the same time last year, according to CredAbility.
Consumers in each of the nation's 75 largest metro areas recorded gains in their overall financial health in the fourth quarter, the first time since 2008 that the average U.S. household has not been considered in financial distress for three consecutive quarters.
Omaha was the country's most financially sound city, with a fourth-quarter score of 80.27.
"The average household appears to have turned the corner, managing credit wisely over the holidays and saving money over concerns that the federal government could have fallen over the 'fiscal cliff,' " said Mark Cole, a CredAbility executive vice president.
This story appeared in print on page D1
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.

subset: commoncrawl


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American Standard 6028.201.068 Blackened Bronze Pvd Dazzle Centerset Bathroom Faucet with Speed Connect Technology
Offer Ends
Contact for Pricing
Call (800) 444-5783, Live Chat, Request a Quote We want to help make your remodel easy and affordable! Please call or chat during business hours using the links at the top of our site to take advantage of this special offer.
We still have product details, accessories, replacement parts and reviews below, scroll down to see them!
California Drought Non-Compliant - 1.2 GPM MaximumThis item cannot be shipped to the following location(s): CA
Technical Specs
|Parts Breakdown
|Installation Guide
|Specification Sheet
|Approved for Commercial Use
|CA Drought Compliant
|Drain Assembly Included
|Escutcheon Included
|Faucet Centers
|Faucet Holes
|Faucet Type
|Bathroom Sink Faucet
|Flow Rate (GPM)
|Handle Material
|Handle Style
|Handles Included
|Low Lead Compliant
|Max Deck Thickness
|Mounting Type
|Number Of Handles
|Overall Height
|Overall Width
|Pop-Up Included
|Spout Height
|Spout Reach
|Valve Included
|Valve Type
|Ceramic Disc
|Water Efficient
|WaterSense Certified
Product Features:
- Fully covered under American Standard's limited lifetime faucet warranty
- Forged from the highest quality brass alloy
- Superior finishing process - finishes are covered under limited lifetime warranty
- Double handle 1/4 turn operation
- Speed Connect pop-up drain assembly takes minutes to install
- ADA compliant
- WaterSense Certified product
- Low lead compliant - complies with federal and state regulations for lead content
- Designed to easily connect to standard U.S. plumbing supply bibs
- Ultra-secure mounting assembly
- All hardware required for installation is included
Product Technologies:
- Lifetime Warranty: As an American company, American Standard faucets are built tough. Their products live longer in one place than most people do. Drip-free ceramic disc valves, high-grade lead-free brass alloys, and stainless steel drain cables name just a few of the features which make American Standard bathroom faucets the industry's longest lasting. To back this up, all American Standard faucets are covered under a lifetime warranty.
- Indestructible Finishes: Through employing only the best finishing practices, such as physical vapor deposition, American Standard faucet finishes are some of the strongest in the industry. When the finish is actually incorporated into the faucet, rather than a coating on the outside, the result is a flawless appearance that eliminates tarnishing, pitting, and peeling while hiding scratches. For this reason, American Standard faucet finishes are fully covered under the lifetime warranty.
- Speed Connect System: Assembling, connecting, and adjusting the pop-up drain within the tight space of a vanity cabinet is undeniably the most difficult task when installing a bathroom faucet. Not so with American Standard, though. Each bathroom faucet is supplied with their patented Speed Connect Drains, which simply plug into the faucet and drain. No wrenches, special tools or plumber's putty are needed. You also won't need to apply torque to seal the drain or to fuss with the lift rod height. With Speed Connect Drains, bathroom faucet installs take minutes, not hours.
- Water Conscious: As the 2012 EPA WaterSense partner of the year, American Standard faucets are acclaimed for saving water without sacrificing performance. Through the use of the latest pressure compensating aerators, American Standard faucets save 32% more water than other brands/models. This means that their faucets pay for themselves throughout the life of their use. They also splash less, too.
Product Specifications:
- Overall Height: 7-1/4" (measured from counter top to the highest part of the faucet)
- Spout Height: 4-3/4" (measured from counter top to the spout outlet)
- Spout Reach: 4-7/8" (measured from the center of the faucet base to the center of spout outlet)
- Number of Installation Holes Required: 3
- Mounts in a centerset configuration
- Center-to-Center Distance Between Handle Installation Holes (Faucet Centers): 4"
- 1.5 gallons-per-minute flow rate
- Installs onto decks up to 1-1/2" thick
- 2 handles included with faucet
- ADA compliant
- Low lead compliant
- 6028.201: This model
- 6028.240: Mini-widespread version of this model
- 6028.801: Widespread version of this model
About American Standard:An American brand with over 140 years of innovations, American Standard is defined by experience, intelligence, and indelible influence. As the patriarch for nearly every key product category for the kitchen and bath, their offering shows a level of thoughtfulness and sophistication that could only be attributed to a company with a legacy as rich as that of American Standard. Today, professional plumbers and contemporary DIY home owners continue to turn to American Standard because they appreciate this legacy and know they can trust the innovations behind each product. It is for this reason that American Standard is so widely used within residential and commercial projects in both the United States and abroad - their products truly deliver, just as they have for generations.
Additional American Standard Links
- View Manufacturer Warranty
- Shop All American Standard Products
- Shop All American Standard Dazzle Collection Products
- Buy Replacement Parts For American Standard 6028.201
Our SKU: 6028.201
This product is listed under the following manufacturer number(s):
- Blackened Bronze PVD*
- Oil Rubbed Bronze*
- Polished Chrome*
- Satin Nickel*
*Denotes a finish or option that has been discontinued
2 Questions from the Community
The American Standard 6028.201 has a PVD finish which stands for physical vapor deposition, the PVD finish helps by making it more scratch resistant and doesn't tatnish film.
I am interested in the blackened bronze PVD finish. But first I would like to know what PVD stands for?
A. The American Standard 6028.201 has a PVD finish which stands for physical vapor deposition, the PVD finish helps by making it more scratch resistant and doesn't tatnish film.
The American Standard 6028.201 has a PVD finish which stands for physical vapor deposition which helps with tarnish and scratch resistance
One of your available finishes is blackened bronze PVD. What does PVD stand for?
A. The American Standard 6028.201 has a PVD finish which stands for physical vapor deposition which helps with tarnish and scratch resistance
Product Reviews
American Standard
American Standard Dazzle Collection
Other Products In The American Standard Dazzle Collection
American Standard T028.900
Dazzle Deck Mounted Roman Tub Faucet Trim with Met...$302.90-$425.75
American Standard 6028.801
Dazzle Widespread Bathroom Faucet with Speed Conne...$211.30-$295.03(3)
American Standard T028.502
Dazzle Tub and Shower Trim Package with Multi-Func...$131.20-$149.99
American Standard 6028.190
Towel Ring from the Dazzle Collection$30.80-$30.80(1)
American Standard 6028.180
Dazzle 18" Towel Bar$44.80-$44.80
Warranty Info
American Standard Faucet Lifetime Function and Finish Limited Warranty American-Standard warrants this product to be free from defects in materials or workmanship for as long as the original consumer purchaser owns their home. American-Standard will provide, free of charge, at it's sole option, replacement part(s) or product (or if no longer available, a comparable product) to replace those which have proven defective in materials or workmanship. Proof of purchase (original sales receipt) from the original consumer purchaser must be made available to American-Standard for all limited warranty claims. This limited warranty is non transferable. It does not apply in the event of product damage due to the use of other than genuine American-Standard replacement parts, installation error, abuse, misuse, or improper care and maintenance (whether performed by a plumber, contractor, service provider or member of the purchaser's household). The limited warranty excludes damage due to aggressive air or water conditions, or harsh or abrasive cleaners and/or materials. This limited warranty excludes all industrial, commercial and business usage, whose purchasers are hereby extended a two year limited warranty (with the exception of solenoid valves and other electronic components which carry a one year limited warranty) applying to all other terms of this limited warranty except duration. This limited warranty does not cover labor charges incurred and/or damages sustained in installation, repair or replacement, nor incidental or consequential damages, all of which are expressly disclaimed. This limited warranty is applicable only to American-Standard faucets manufactured after June 1, 1996 and installed in the United States and/or Canada. This limited warranty gives the original consumer purchaser of an America-Standard faucet specific legal rights which may vary from state to state or from province to province. This limited warranty does not cover any liability for consequential or incidental damages, all of which are hereby expressly disclaimed, or the extension beyond the duration of this limited warranty of any implied limited warranties, including those of merchantability or fitness for an intended purpose. In some states or provinces the exclusion or limitation of incidental or consequential damages is not allowed, so those exclusions may not apply to you.


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Men's Jordan Trunner Dominate Flx Training Shoes
Buy Online & Pick Up In-Store
Dominate the competition in pure Jordan style in the Men's Jordan Trunner Dominate Flx Training Shoes. Featuring Dynamic Fit technology, these training shoes deliver lightweight support that moves with your foot during varied workouts for an unparalleled training experience.
Thanks to the Air-Sole unit and lightweight, breathable upper, total sport domination is easy when you train in the Jordan Trunner Dominate Flx. The deep, moulded Nike Free-inspired flex grooves at midsole and outsole offer the flexibility necessary for any training workout, while the combination leather and synthetic upper delivers lightweight comfort and support as you work on your exercises.
Look good and train harder in the off-season to crush the competition with the Jordan Trunner Dominate Flx Training Shoes.
- UPPER: Synthetic and mesh
- MIDSOLE: Flex grooves
- OUTSOLE: Rubber


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05-14 FJ Cruiser
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Devi strips out of her sexy pink and bra set for her "playtime" with her rabbit toy! Every girl must own one! She is super horny and super wet. She fucks herself hard and fast until she once again cums all over! She is a cum queen! At least she has proof of how much naughty fun she is having! No doubt about that!
Devi sits on her leather chair totally naked while she masturbates with her pink vibrator. Good thing she is on leather because she cums all over! It literally drips out of her pussy and down her leg..on to the chair. Messy girl is quite pleased with that play session. You might want to turn down your speakers..her moans and groans are pretty loud.
Devi admits she LOVES to suck dick! She gives us all a lesson ..showing us all her juicy details and what she wants to do to YOUR hard cock! She not only gives the big cock an awesome deep blowjob, she titty fucks it, then puts it in her super wet pussy...fucking it on the kitchen countertop. She is one horny girl!


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Belknap County Delegation lawyers up after defiant commissioners raid budget to boost benefits
The decision followed close on the heels of a meeting of the Executive Committee of the convention, which confirmed that the commission has shuffled money within departmental budgets to fund employee benefits the convention stripped from the 2013 budget as well as withdrawn funds from the contingency account without the approval of the committee.
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SANTA CLARA -- Running back Marcus Lattimore said it's "cool with me" that he indeed will start his rookie season with the 49ers on the non-football-injury list, as coach Jim Harbaugh confirmed Friday.
Lattimore continues to rehabilitate well from an October hit that tore three ligaments in his right knee.
"Things have been going good. Patience, that's all it is now," said Lattimore, who started training camp on the active/non-football-injury list and will remain there through at least the season's first six weeks.
Aside from his recovery, Lattimore is learning his craft at an NFL level, crediting Frank Gore's leadership and position coach Tom Rathman's mentorship in how to read defenses and use proper techniques.
Lattimore, a South Carolina product, is "grateful" to be surrounded by a close-knit team that's coming off the franchise's first-ever Super Bowl defeat.
"Everybody looks out for each other," Lattimore said. "This team's different. Everybody cares about each other, and they care about winning. That's all it really takes.
"Of course we have the talent, ain't no need to say that, especially on the offensive line and defensive line, where it matters. I'm just grateful to be here."
Monday's trading away of 2012 first-round pick A.J. Jenkins served as another reminder to Lattimore about the NFL's mentality.
"It's strictly business," Lattimore said. "In the five or six months I've been here, I've seen guys come and go, come and go, come and go. It's just part of it. No hard feelings between the coaches and players. I never see anybody say anything. It's just the way it is and can happen at any time."
For more on the 49ers, see Cam Inman's Hot Read blog at blogs.mercurynews.com/49ers. Follow him on Twitter at twitter.com/CamInman.


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For a Phase 1 antibody project, the primary objective of our cell line development group is to deliver a stable, high performing, clonal cell line in an aggressive timeframe, leaving little time to react to the challenges associated with cell line instability, such as dramatically reduced product expression. Our current cell line development timeline allows for 6.5 months from transfection to the establishment of a cell bank for a lead clone, which is expected to deliver 1–3 g/L in a fed-batch process. Our cell line selection process consists of numerous rounds of successive screening, initially assessing hundreds of clones. During that time, clones are eliminated because of poor performance in scaled-down models of the fed-batch process or because of a loss of product expression over time. When such instability in product expression occurs for a lead clone at a late stage in the timeline, both upstream and downstream process groups must quickly identify alternatives so that the material needs of the project will be satisfied and deadlines are still met.
This manuscript presents examples of cell line instability that we have encountered during Phase 1 antibody projects, and the operational consequences that have ensued. It describes the different types of instability we have observed, our attempts to analyze the presumptive underlying genotypic causes of these different types of instability, and the general methods and tools that we use to investigate cell line instability. Finally, we describe the recent development of an RT-PCR–based assay that allows us to eliminate potentially unstable cell lines from consideration early in the cell line development timeline.
Although our cell line development group has been successful in meeting our project goal of generating Chinese hamster ovary (CHO) Phase 1 cell lines that can deliver >1 g/L in a platform production process, cell line instability occurring at a late stage in the adaptation period timeline has resulted in both upstream and downstream process groups scrambling to deal effectively with last-minute changes to meet deadlines. Hence, we have developed specific methods and approaches to enable an increased understanding of the root causes of our observed cell line instability. This knowledge potentially could be used for the early, proactive identification of unstable clones or the elimination of cell line instability altogether. This would be highly beneficial to the cell line and cell culture process development organization, thus ensuring sustainable success in meeting deliverables and timelines.


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project announcement: help me, help you
Lately, I've been getting a lot of emails from loyal Jen's Love Lesson readers like you with questions about love, sex, and marriage, my new book, and even questions about my own personal life. As I've been struggling to email everyone back in a timely manner, I realized that I could do this in a much more efficient way.
Let me explain. One of my favorite blogs right now is Young House Love. It's a do-it-yourself home improvement blog, written by a dynamic husband and wife duo, that I've become mildly obsessed with in recent weeks. And, they have a a TON of readers. Seriously, a TON. Which also means that they get a TON of questions from readers about anything and everything. Anywho, one of the things that they do to answer all of these pressing questions in an organized fashion is to make video responses (You can see two of those videos HERE and HERE). After I watched them, I thought to myself, "I could do that!" Not only can I do it, but I also think it would be WAY more fun that emailing all of you back individually.
Interested yet? Here's how it's gonna work:
Between now and September 30th, I'll be collecting questions from you via my Facebook fan page, through email (firstname.lastname@example.com), or by commenting on this post. You can ask me ANYTHING. Really, I'm pretty much an open book. Then, I'll categorize your submissions into 3 groups:
(1) questions about love, sex, & relationships,
(2) questions about my new book (Make Love, Not Scrapbooks), and
(3) questions about my own personal life (including questions about Hus and my twins).
Lastly, I'll make a few videos for your viewing pleasure. Have you thought of your question yet? Good! Now all you need to do is decide if you want to privately email it to me (email@example.com), write it on the wall of my Facebook fan page (click on the link, "like" my page, and then ask your question by "writing something" on my wall), or comment at the bottom of this post (by clicking on the comment button below).
I'm super pumped about this project and I hope that you are too!
Ready, set, go!
5 comments:
ooo, i've been waiting for something like this!
what is the best part of your marriage to hus?
what is your guilty pleasure?
- September 9, 2011 at 6:11 PM
My boyfriend and I break up and get back together a lot. We're currently together, but we've been on again off again for two years now, going on a break during any serious argument. Is this terrible? Are we doomed?
- September 9, 2011 at 8:14 PM
What is your favorite thing to do on the weekends?
- September 13, 2011 at 9:11 AM
If you had to pick only ONE thing that every marriage needs, what would it be?
- September 16, 2011 at 8:47 AM
How would you translate your advice to relationships where one person is on the road a lot (e.g., every other week) and (so it isn't too easy), where there are young kids and no inexpensive babysitters in the vicinity?
- November 9, 2011 at 2:10 AM
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STOCKTON – The city's police union will begin voting next week on a new contract, possibly putting to rest a contentious battle between officers and City Hall in uncertain times for Stockton.
The 335 members of the Stockton Police Officers' Association are expected to begin casting their votes Nov. 27 with a result due by Dec. 4. If the contract passes, the City Council would be asked to ratify it Dec. 11.
The police union is the last holdout of the city's nine labor groups to renew a contract since the Stockton filed bankruptcy June 28. The city struggles with retaining and recruiting officers amid a record high crime spree in Stockton.
The relationship between the city and the union, which degraded last year to name-calling, hit a low when the union bought the house next door to City Manager Bob Deis. It remains uncertain if the union will approve the new contract.
Read Thursday's Record for more on this story by staff writer Scott Smith.
Location, ST | website.com


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A Campbellsville man has been arrested and charged after he allegedly assaulted jail staff while in custody at the Taylor County Detention Center.
Aaron Gibson, 24, of 352 W. Broadway, Apt. 6, was arrested Jan. 25 at 5:09 p.m.
According to Gibson's arrest citation, he was originally arrested and charged with assaulting a woman by throwing her on a bed and choking her.
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5 Foods You Should Never Eat
It does a waistline good: The high protein content makes you feel satisfied, plus a study published in the American Journal of Clinical Nutrition found that people who consumed an average of 12 ounces of dairy a day slimmed down more than those who drank just half a glass.
Downing two glasses before every meal can help you shed lbs, according to a Virginia Tech study. How? It makes you feel fuller so you end up eating less. Dieters who used this technique chowed down fewer calories and lost more weight than those who didn't load up on H2O.
10 Foods That Will Speed Up Your Metabolism


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'Game of Thrones' Star Kristian Nairn on His 'Weird Second Coming Out'
Kristian Nairn, who plays Hodor on HBO's hit series "Game of Thrones," told his mother he was gay when he was 12 years old. And by the time he was 16, he said, all of his friends and acquaintances knew.
So it was a strange phenomenon for the 38-year-old actor when, earlier this month, numerous media outlets like Rolling Stone, Huffington Post and People announced that he had come out.
"I couldn't believe the nuclear mushroom," he told Speakeasy. "It's always been the way. It's not as if I suddenly went, 'Hi guys' and put a boa on."
The reaction stemmed from an interview with WinterIsComing.net in which Nairn responded to a question involving the "gay community." The Belfast-based actor, who is also a DJ, responded that "when you talk about 'the gay community,' you are talking about MY community."
"For me it's been like a weird second coming out," Nairn told Speakeasy. "It felt a little bit unnecessary. It's just really strange. It didn't feel very important to me. I just mentioned it casually in an interview."
Nairn recently sat down with Speakeasy to discuss this phenomenon, playing one of the most popular characters in the series, and his concerns about carrying Isaac Hempstead Wright—who plays Bran—as the actor grows up.
Edited excerpts:
So did this second coming out happen inadvertently?
Kristian Nairn: I kind of had been waiting for it to come up in an interview question. But I sort of thought that people knew, because all you had to do—I started out doing a drag queen [act]. I DJ at a gay bar. Learn to Google, people. That's all it is.
So it was a weird media coming out?
Yeah, I tell you what: I don't want to make light of it either because people have been in touch with me and they've been really…nice about it, and I'm really grateful. And also people said it inspired them. Because even within the gay community, there's a stereotype even when you're a gay person. You have to look a certain way. You have to be thin. You have to be tanned. You have to have small eyebrows. You have to look pretty. And that's never been me.
I just think it's important to show the world that we are varied people, as everybody else. You don't have to be any way. I think that's really important, and people said that to me. And that's when I started to realize it's not a small thing. It's kind of a big thing. And if I can help somebody—you know, I've got my family behind me. I've got my friends behind me. If you have that, that's all you need. It doesn't matter about people on the Internet. And I'm really lucky to have that. And so if I can help one person, I'm happy.
So the reaction has been positive from fans?
I would say the ratio is about three negative comments to a thousand. It's pretty good.
Let's talk about Hodor. How did you get the role?
I was DJ-ing and I always did live theater and live musical theater. I never was really interested in going to TV or film, but I had an agent for the live stuff who put me forward for a movie called "Hot Fuzz." I didn't get the part, and then four years later—four years later—I got the call from the same casting director. And they were like, "You're perfect for this part. I want you to come in." The rest is history.
Do you have concerns that Isaac Hempstead Wright, who plays Bran, is getting to be too big to carry? I know he's still quite small now.
I have major concerns. He is not small.
I saw him at the premiere.
Yeah, he's pretty small. But he used to be this size [gestures] and now he's like here [gestures higher]. You try carrying him. [laughs]
So you have concerns?
Well my back has concerns. I'm actually seeing a chiropractor, because we have to do scenes over and over and over.
Is this part of the show's health plan?
We don't have a health plan. You go to the doctor.
That is a work hazard.
Yeah, of course. [laughs] But I signed up for it. I said I'll do it. So it's changed my life and I cannot complain.
People have said your role is either the easiest or the hardest. Which is it?
I'm going to go for it's one of the hardest. People who actually know anything about acting know that it's not easy to show a million emotions—and subtle emotions with just your face and your body language—while you're carrying a child.
It's not easy. Do you know what? I have never done anything harder in my life. At the end of the day, I'm a zombie—an absolute zombie, but I love it. It's so fulfilling.
Did you have any idea your character would become so popular?
[Showrunners] Dave [Benioff] and Dan [Weiss] told me before the show. They're like, "Your character's not one of the main characters, but it's probably one of the most popular—if not the most popular. Everyone's going to say 'Hodor.'" I was like, "Really? I don't think so." My mom's a huge "Game of Thrones" fan. She was like, "I love Hodor. I think there's more to him and something's going to come out eventually along the line." She was right. They were right. I was wrong.
You got teased onstage at the fan event by George R.R. Martin about not reading the books.
[laughs] How embarrassing. Imagine sitting beside George R.R. Martin and being called out that you haven't read my books.
Are there plans to remedy the situation?
No, especially not after that. [laughs]
Have there been any crazy fan reactions here in New York?
No, people are very nice. They just yell "Hodor" a lot. That's basically it. What else are they gonna say to me? They expect me to say it back, and I'm like, "What? What do you want?" No, not really. I love it.
In New York people see famous people all the time. In L.A. people see famous people all the time. And I tend to be either here or L.A. and people are used to it. I met Sally Field at the premiere, and I'm a huge fan of Sally Field and I made a complete idiot out of myself.
I'm sure you didn't.
No, no, no I really did. I asked her the same question 10 times. "Are you having a good night?" And she was like, "Uh, yes." And then about two minutes later it was like, "Are you enjoying yourself tonight?" And she's like, "Yeah, yeah, I really am." Time's up.
Write to Robin Kawakami at email@example.com. Follow @robinha
More Game of Thrones Coverage:
- George R.R. Martin Shelved Cameo to Work on 'Winds of Winter'
- George R.R. Martin, 'Game of Thrones' Stars Greet Fans at Barclays Center
- A Surprise WSJ Visit From 'Game of Thrones' Star
- King Joffrey Likes Snow Cones
- Inside the 'Game of Thrones' Premiere With Peter Dinklage, Emilia Clarke
- The National's Matt Berninger Wants to Be Beheaded on 'Game of Thrones'
- Emilia Clarke, the Breakthrough Actress on 'Game of Thrones'


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Troutbeck Cottages
Just show me Troutbeck Cottages
A holiday in a Troutbeck cottage promises the perfect
ingredients for a truly relaxing break in the Lake District
National Park.
The village links a string of small hamlets along a beautiful
valley, midway between Windermere and Ambleside off the Kirkstone
Pass. A Conservation Area, the atmosphere is sleepy, almost
old-fashioned and many of the cottages and buildings boast charming
architectural features like mullioned windows, cylindrical chimneys
and exposed spinning galleries. Now in the hands of the National
Trust, Troutbeck Park Farm was once the home of Beatrix Potter,
where she bred flocks of Herdwick sheep.
One of the village's oldest properties, Townend House, is
also protected by the Trust - a splendid 17th Century Yeoman's
house, with stone mullioned windows, carved oak panelling and stone
flagged floors. Another interesting old building is Jesus Church,
renowned for its pre-Raphaelite, stained glass windows.
Park up your car and head out on foot, bike or horse along miles
of footpaths and bridleways weaving through the valley. Try the
Troutbeck Circuit, the Kentmere Round; look out for Lake Windermere
occasionally on the horizon. And don't miss the Kirkstone Pass
for amazing views across to Patterdale, Glenridding and Ullswater.
Expect to eat well in a Troutbeck cottage!
Choose from one of the fine dining gastro-pubs or enjoy a cosy
night's supper sampling delicacies from the well-stocked
village shop. And if you time your stay around Shrove Tuesday,
enjoy food and fun at Troutbeck's annual Pancake Races!
Rest assured, when you book a Troutbeck cottage, you'll
discover one of the quietest, prettiest spots in the Lake District.


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USA, 1995, 108 Minute Running Time
Genre/Subjects: American Indie, Black Comedy, Film Noir, Gay/Lesbian, Thriller, Womens IssuesLanguage: English
35mm presentation - The Wachowskis' remarkable directorial debut is a revisionist take on the film noirs of the 1940s. Part THE POSTMAN ALWAYS RINGS TWICE, SIN CITY (a gritty detective comic book that inspired the look of the film), and THELMA & LOUISE (an admittedly key influence), BOUND brilliantly evokes the moody atmosphere of early noir, but with a unique, modern edge. Jennifer Tilly plays Violet, a gangster's mistress who wants out of the mob life. A live action Betty Boop (all soft curves and a sweet, breathy voice), Violet may seem just another incarnation of the beautiful, yet dim brunette Tilly has played before (as in her Oscar-nominated role in BULLETS OVER BROADWAY). But it turns out that Violet is smarter and tougher than she lets on--and meets her match in Corky (Gina Gershon), the sexy, sapphic ex-con next door. Joe Pantoliano rounds out the impeccable cast as Ceasar, the brutish boyfriend and intended fall guy in Corky and Violet's eventual plan to steal the mob's money. Whether the plan works, and whether the two can trust each other enough to see it through, is played out perfectly in this sharp, satisfying neo-noir that pays tribute to the genre, while turning it on its head.
DIRECTOR: Larry Wachowski, Andy Wachowski
Principal Cast: Jennifer Tilly, Gina Gershon, Joe Pantoliano, John RyanUS Distributor: Universal Pictures
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We Can Ride, Inc. is a 501(c)(3) nonprofit, volunteer-based organization whose mission is serving children and adults living with physical, cognitive, emotional, and behavioral disabilities. Our goal is to enhance our client's skills and well being through challenging programs of therapeutic horseback riding.
We Can Ride, Inc. is a Premier Accredited Therapeutic Riding Center with PATH International (Professional Association of Therapeutic Horsemanship International).
We Can Ride, Inc. operates with the talents of:
1. A volunteer Board of Directors involved in all programs
2. A committed staff
3. Credentialed physical and occupational therapists
4. PATH certified therapeutic riding instructors
5. Trained and dedicated volunteers
6. Specially trained horses and ponies


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3.9-8 Status of Parties - Exceeding the Limits of Invitee
Revised to January 1, 2008
You have heard testimony
that at the time of the accident the plaintiff was <insert
specific facts> on the defendant's premises. The defendant has
claimed that the plaintiff had exceeded the limits of the invitation
at the time of the accident by leaving that portion of the premises
intended for the use of patrons and entering a part where the
possessor could not reasonably have foreseen that patrons would
enter. The plaintiff disagrees and claims that even if you find a
departure from the portion of the premises intended for the use of
patrons, the plaintiff had the right to assume that the place where
the accident occurred was one which patrons had the right to use.
You must decide whether
the plaintiff remained an invitee on the defendant's premises or
whether, under the circumstances, (he/she) became a trespasser. I
instructed you earlier on those definitions.
There are circumstances
under which a business invitee may go outside the portion of the
premises which the possessor intends patrons to use and still be
entitled to the exercise of reasonable care from the defendant.
Such a situation occurs when the possessor, in view of all the
circumstances, ought reasonably to have anticipated that patrons
were likely to enter a part of the premises not primarily intended
for their use.
If you find that the
plaintiff was using the premises in a way that the defendant could
have reasonably anticipated them to be used, then the plaintiff
remained an invitee at the time of the accident. If you find that
the plaintiff was using the premises in a way that the defendant
could not have reasonably anticipated, then the plaintiff lost
(his/her) invitee status.
Ford v. Hotel & Restaurant Employees & Bartenders International Union,
155 Conn. 24, 33-34 (1967).
"An invitation usually
includes the use of such parts of the premises as the visitor
reasonably believes are held open to him as a means of access to or
egress from the place where his purpose is to be carried out."
Ford v. Hotel & Restaurant Employees & Bartenders International
Union, supra, 155 Conn. 33.
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When it comes to surging in Iraq, it's "encouraging" out there. So the President tells us ("Yet even at this early hour, there are some encouraging signs…"); so Lt. Gen. David Petraeus, the surge commander in Baghdad, tells us ("[It's] too early to discern significant trends, [but] there have been a few encouraging signs…"). No, they're not talking about what Juan Cole calls the "new spate of massive and deadly bombings [that] has spread insecurity and further compromised the Iraqi government… right in downtown Baghdad, within spitting distance of the Green Zone, where the U.S. and the Iraqi government planned out the new security arrangements"; they're referring to some weapons caches found, some under-strength Iraqi units deployed to the capital, a possible small drop in deaths from sectarian violence.
Still, if surge success isn't exactly looming on the horizon, it's clear enough what is: Call it "surge creep." In a way, surge creep has been the story of the Iraq War since the beginning.
Numbers creep: As Tom Ricks has reported in his book Fiasco,when the Bush administration first invaded Iraq in March 2003, its top officials believed that, by August, most American troops would be withdrawn. Only 30,000 or so would remain to garrison a grateful country. That, of course, was four years ago. Today, American troop totals in Iraq are heading back towards 160,000-plus.
The forces for the surge plan alone, announced at 21,500 by the President in January, are already creeping toward 30,000. Recently, the administration "clarified" all this in a piecemeal sort of way. Deputy Secretary of Defense Gordon England explained to Congress that the surge combat units might well need up to 7,000 more support troops. He suggested this in rejecting "a recent estimate by the non-partisan Congressional Budget Office that the surge would require an additional 15,000-28,000 support personnel." (Keep that figure in the back of your mind, as surge creep continues.) Then Lt. Gen. Petraeus requested 2,200 extra military police for all the detainees he plans to pick up in sweeps of Baghdad neighborhoods. The President signed off on them this week. Whether they are part of those up to 7,000 support troops or not remains foggy; meanwhile Maj. Gen. Benjamin R. Mixon, the commander of American forces outside the surge zone in Northern Iraq, just called for reinforcements for Diyala Province where attacks have risen 30%.
Known and very popular cialis coupon which gives all the chance to receive a discount for a preparation which has to be available and exactly cialis coupons has been found in the distant room of this big house about which wood-grouses in the houses tell.
Money creep: The administration supposedly budgeted $5.6 billion for the new surge plan in the capital and al-Anbar Province. But that was January, this is March. Another billion dollars or so has already been added on for those extra "support troops" (that no one had evidently given a thought to a month and a half ago) and — among easy predictions — look for real costs to creep ever higher, as they have done since March 2003.
Time creep: When the surge plan was first proposed in January, then-commanding general George W. Casey Jr. suggested that it might be successfully completed, with Baghdadis "feeling safe" in their neighborhoods, by "the summer, late summer." Soon enough, new Secretary of Defense Robert Gates let it be known that the time estimate had crept into the fall, when, he felt sure, the surge might begin to be "reversed." Now, Petraeus is talking about extending the (rising) surge troop levels into the winter; his second-in-command, Lt. Gen. Raymond Odierno, is already floating the idea of surging into February 2008; and, according to the Washington Post, some commanders under them in Baghdad are "predicting that U.S. troop levels in the Iraqi capital will have to remain elevated until at least the spring of 2008." This sort of time creep — like the numbers creep and the money creep — has been an ongoing aspect of the administration's Iraq for years now.
Blame creep: Finally, we can already see the first little surge of blame creep out of Baghdad. Petraeus, not even a month in the Iraqi capital, has evidently taken a good hard look around and found things not exactly to his liking. He's just held his first news conference and offered his mantra for saving the capital (or at least his own rep): "There is no military solution to a problem like that in Iraq, to the insurgency of Iraq... Military action is necessary to help improve security... but it is not sufficient." Such comments are already getting him headlines like: "U.S. commander says no military solution in Iraq." Think of the general as carefully beginning to signal his future explanation for the failure of the surge plan. (Those dopes in Washington couldn't handle the politics of the situation.) Remember: If you're going to blame someone convincingly, you have to plant your story early.
In the meantime, what will the President's surge plan actually do? Let Michael Schwartz — who has regularly managed to prove more accurate in his Iraqi assessments from thousands of miles away than a bevy of reporters on the scene — fill you in. Tom
Copyright 2007 Michael Schwartz
Surge and DestroyThe Brutality Escalates in Iraq
By Michael Schwartz
If you are trying to figure out how the new Bush strategy is progressing, or just trying to figure out what is happening in Iraq, here is a diagnosis and a bit of a prognosis.
In his speech, Bush promised three prongs to his new strategy: (1) attacking and neutralizing Moqtada al-Sadr's Mahdi Army militia; (2) confronting Iran; and (3) a new offensive against the Sunni insurgents.
Neutralizing the Mahdi Army: Since 2004, cleric Moqtada al-Sadr has been the Shiite the Bush administration has most loved to hate. Early in the war, occupation officials tried to have him arrested and fought three large battles (two in Najaf, one in the vast Baghdad slum of Sadr City) in an attempt to suppress his guerrilla militia, the Mahdi Army. Each time, he and his forces, deeply entrenched in Sadr City, have bounced back stronger and more popular than ever. In its fourth manifestation, the intention to dislodge, disrupt, or destroy the Mahdi Army appears guaranteed to fail. It is just a matter of what sort of failure the U.S. will choose.
As the new strategy has so far been implemented, American military tactics seem designed to yield a relatively modest failure, though one that may prove indirectly responsible for significant Iraqi civilian casualties. U.S. troops have begun operations in Sadrist strongholds (notably Sadr City), which were, until late last year, American "no-go zones." But they are not attempting to pacify them, as they have been Sunni neighborhoods in the capital. Instead they are mounting raids designed to arrest specific Sadrist leaders, while leaving the rest of the community alone. So far, Sadr's men have decided to lay low and not resist the American intrusions (though the targeted individuals are frequently gone when the Americans arrive, often resulting, evidently, in the arrest of any fighting age man in the vicinity). There are even rumors that Sadr is cooperating with at least some of the arrests, allowing the Americans to apprehend "rogue" Mahdi Army leaders who have not been following his orders.
Whatever the story may be, this strategy will leave the strength of the Mahdis, — who are not just a militia but, like Hezbollah in Lebanon, a social movement with deep and complex ties to, and support from, poor Shiite communities — unimpaired. It cannot generate sufficient arrests to decapitate the militia; nor can its "hit and run" tactics undermine the political and military domination exercised by the Sadrists in these neighborhoods. At best, it is a kind of ongoing harassment, a symbolic denial of Sadrist power.
It will not be surprising, therefore, if the U.S. escalates these raids into larger-scale attacks on Sadrist strongholds. If this were done, it would involve the sort of brutal invasions currently being undertaken in Sunni neighborhoods. Typically these attacks begin when U.S. troops close off an area, demand that all women and children leave, and then initiate a house-to-house sweep, treating the community, in essence, as a "free fire zone." Each house is inspected for lurking insurgents or other suspicious characters (sometimes simply any men of fighting age) and searched for arms caches (which are plentiful). Anyone that evades the invaders, hinders the search, or offers any sort of resistance may be considered an enemy combatant. The level of destruction can be quite awesome.
If the U.S. tries this in Sadrist strongholds, the Mahdis will have no choice but to fight back; they will not sit by while their communities are savaged. This could trigger a guerrilla confrontation in Shiite communities much like the ferocious fighting that has been seen in Sunni areas. The battle of Tal Afar, which, in 2005, turned parts of that city into ghost neighborhoods and reduced a quarter of it to rubble (still not cleared away), has been explicitly mentioned as a "model" for these sorts of offensives.
It is one thing to mount such attacks against Iraq's Sunni minority. Used against the 60% majority Shia community, these tactics would likely spur a response that would spread around the country and prove disastrous for American plans, which are already in tatters. The Mahdis would certainly retaliate in other neighborhoods; wherever, in fact, the Americans are vulnerable. If the U.S. military is already almost drowning in the Sunni insurgency, imagine the predicament of American troops should they suddenly have to fight any significant number of Shia as well.
Such a development would have two clear consequences: an exponential growth in the strain on an already overstretched American military and a dramatic increase in the use of air power to back up embattled troops on the ground. Together, these could result not just in massacres, but in the rubble-ization of significant parts of Baghdad and possibly other Iraqi cities.
If the U.S. military stays with its current strategy of surgical incursions, it might escape with only a modest defeat. If it escalates, it is courting unmitigated disaster in the wake of unprecedented brutality.
Confronting Iran: There are all sorts of symptoms of the new approach to Iran, including the (mostly trumped up) accusations about that country supplying Iraqi insurgents with advanced weaponry, the arrests of accused Iranian infiltrators and their Iraqi allies, and the stationing of a second aircraft-carrier task force in the Persian Gulf (with possibly two more on the way). And the U.S. and foreign media have been carrying a constant stream of reports about possible U.S. or Israeli air attacks on Iran itself.
Bush administration accusations of Iranian "interference" in the Iraqi political and military situation are particularly ironic, and not just because the idea of the U.S. accusing anyone else of "outside interference" in Iraq is so absurd. The added irony derives from the administration's most dramatic claim — that the Iranians are supplying the insurgency with a new type of IED that can pierce armor.
There is plenty of dispute over the accuracy of this charge, but if the Iranians are supplying sophisticated IEDs, it's to the Shia insurgents (even the U.S. military admits to that); and the U.S. is not (currently) fighting the Shia insurgents, it's fighting Sunni insurgents, who hate Iran just as much as — possibly more than — the U.S. However, this accusation is most often stripped of this critical "detail" in the media (especially on the TV news). Therefore, the impression is left that a large proportion of American casualties are somehow being caused by Iranian technology. That, too, is absurd.
The same can be said about most other administration claims against Iran, including those about that country's possible nuclear-weapons program. The latest U.S. intelligence reports indicate that the Iranians could develop a bomb in perhaps five to ten years, hardly the sort of immediate threat that might provide a handy justification for an attack on Iran's nuclear facilities.
But the fact that these accusations are so spindly only adds to fears that the administration is constructing a web of lies, half-truths, and cherry-picked intelligence in order to justify an already-planned attack — just as its top officials did four years ago in the run-up to the invasion of Iraq.
There are, unfortunately, plenty of indications that the U.S. might indeed be preparing to attack Iran or have the Israelis do it. The presence of two aircraft carrier battle groups is but the most visible (with a third and even a fourth one rumored to be en route); the appointment of the first Navy man, Adm. William J. Fallon, to head Centcom — and he has a background in naval aviation at that — is another; and the recent reports of behind-the-scenes protests over a possible air assault on Iran from top military officers (including unprecedented threats of high-level resignations) are all tangible signs of serious intent.
But many similar indications were present last spring and no attack occurred, presumably because saner heads inside the Bush administration prevailed. This reflects the fact that, even from the point of view of many of those who embrace the goal of American preeminence in the Middle East (which might indeed call for reversing the upward trajectory of Iranian regional power), such an attack might well appear to be counterproductive.
Instead of stabilizing the situation in Iraq and reducing Iranian leverage in the region, it would likely destabilize Iraq further (because Iran's Shia allies there would certainly respond forcefully and violently), and it might even undermine the viability of Saudi Arabia (because Shia rebellions could spread to the oil-rich areas of that country). Most significantly, instead of dislodging the Iranian regime, an American attack, no matter how powerful, would probably entrench it — and at a terrible cost. Instead of restoring American credibility as an indomitable military presence in the Middle East, the failure of such an attack would further undermine it (as Israel's fruitless attack on Lebanon did for it last summer).
The logic of the situation suggests that all this is saber-rattling; an attempt to use the threat of war to wrest concessions from the Iranians. But we are dealing with the Bush administration, which has a habit of pursuing "counterproductive" policies. We must watch the events of the coming months, particularly the current talk about actual negotiations between the administration and the Iranian regime, carefully. This one could tip either way.
Attacking the Sunni insurgents: What might happen sooner or later in Shia neighborhoods is already the reality in Sunni communities and cities. For the most part, the new strategy in Sunni areas of Baghdad is the same old strategy, seen not only in major battles like those of Falluja and Tal Afar, but in various neighborhoods of cities like Ramadi, Mosul, or Samarra. There is, however, a new twist: The Americans now intend to keep troops at fortified mini-bases in many of Baghdad's Sunni neighborhoods — supposedly to establish long-term stability and facilitate reconstruction — after (and sometimes even before) they are "cleared of insurgents." The small forward bases — really glorified police stations — will be placed in the middle of Baghdad "hot spots."
The first prong of this new policy is doomed. No area in Baghdad, or for that matter in Iraq, has been successfully pacified in this manner. That includes Falluja and Tal Afar, where this very strategy has been applied and has failed. About 1,000 American soldiers, supplemented by Iraqi (Shia) troops, have been in Falluja for 27 months since the city was "cleared" (that is, largely destroyed). They have established a particularly harsh form of martial law and yet the insurgency in the city, without ever having disappeared, has slowly grown again in strength. Falluja is not pacified and the Americans have never actually initiated a real program of reconstruction there. In other cities, with less comprehensive occupations, the insurgency is even more robust, and there isn't even talk of reconstruction.
American implementation of this plan in Baghdad has already begun, with a devastating offensive in the Haifa Street area, near the heavily fortified Green Zone, which quickly escalated into the wholesale destruction of the neighborhood. Once the initial onslaught was over, the offensive devolved into a case of Shiite ethnic cleansing; Sunni residents who left during the heavy fighting are not being allowed back in by the Shia police and troops who arrived with the Americans. We can expect a regular diet of such clashes, possibly marked by the liberal use of air power, guaranteed to devastate neighborhoods, followed by sectarian struggles over who will repossess the destroyed buildings, usually resolved in favor of the Shia allies of the American troops.
The second prong of the new policy — the creation of a permanent U.S. presence in insurgent strongholds, is only now beginning to be implemented. Besides the fact that the planned number of outposts (not more than 50 in any published estimates), could not hope to purge the city of Sunni insurgents, this tactic will provide stationary targets for guerrilla fighters — invitations for well-planned attacks. In Ramadi, where this strategy is being implemented, there has already been a successful car-bombing at the most important of the American posts, and it seems likely that this is only the beginning. We should expect reports of various forms of attacks against these bases as soon as the Sunni insurgents get their bearings and develop their strategic plans.
The Bottom Line: We are looking at desperate measures aimed at reversing the decline of American power in the Middle East. In all three areas designated by the surge plan, this desperation has led to the consideration of, or even the embrace of, more destructive strategies.
The immediate results on the ground already look disastrous in ways that — though they shouldn't — invariably seem to catch Americans officials off-guard. For instance, when they focus the limited forces available to them on Baghdad, the guerillas begin to look for less well guarded targets elsewhere as seems now to be happening in the city of Samarra. In addition, even the so far modest American incursions into Shia areas of the capital have had the horrifying effect of facilitating some of the most horrendous suicide car-bombings yet recorded. One instance of this was succinctly described by New York Times reporters James Wong and Wassam Habeeb:
"On Feb. 18, just two days after Prime Minister Nuri Kamal al-Maliki called the opening stage of the security drive a 'dazzling success,' two bombs ripped through a market in the New Baghdad neighborhood, where American soldiers had been on patrol just minutes earlier, killing at least 60 people."The way an American patrol and a car bombing coincided was no accident. The New Baghdad neighborhood, like almost all Shia communities in the capital, has been policed by the Mahdi Army on an ongoing basis. Besides enforcing all manner of local law, the Mahdis are also vigilant about possible suicide bombers, quickly recognizing strange people or vehicles that enter their neighborhoods. At the same time, wary citizens are also on the look-out, alerting the local Mahdis whenever they see someone who looks suspicious.
When the Americans come through on patrol or — even worse — when they set up permanent checkpoints (either U.S. or Iraqi-manned), the Mahdis have to lie low, since the Americans (or their Iraqi sidekicks) will arrest or kill them. The community is then essentially left unprotected and open to intruders.
The Sunni jihadists know this, and they also know that the Americans (and their Iraqi sidekicks) have neither the ability nor the inclination to spot and interdict suspicious looking outsiders. So they target precisely those Shia neighborhoods that the Americans are busy "pacifying." Very often, as in the case of the New Baghdad bombing, they time their attacks just after the Americans pass through, and before the Mahdis can return to the streets.
Since the surge policy began, there have been a rash of these almost coordinated bombings, including the sequential car bombs in Sadr City that killed 215, the demolition of the Baghdad booksellers market that killed at least 38, and the attack on Shiite pilgrims outside of Hilla that killed at least 70. In each of these cases, the bombings coincided with U.S. patrols that virtually "ran interference" (to use an unfortunately appropriate football term) for terrorist attacks. And in each case, local residents registered furious complaints that the Mahdi Army had been forced to "stand down."
All of this is unsettling enough. Worse yet, in the confrontation with the Sadrists, the Bush administration appears to be edging toward search-and-destroy operations that will rubble-ize Shia neighborhoods; in the confrontation with Iran, it appears to be lurching toward a possible air assault on a remarkably wide range of targets inside that country, guaranteeing staggering levels of civilian casualties; in the confrontation with the Sunni insurgents, it is already mobilizing its ground and air power with the promise of the subsequent imposition of an extreme form of martial law. The hallmark of all these new strategies is the high level of destruction and mayhem they promise.
There is a larger pattern that should, by now, be clear in these developments, and all that have come before. The architects of American policy in the Middle East tend to keep escalating the level of brutality in search of a way to convince the Iraqis (and now the Iranians) that the only path that avoids indiscriminate slaughter is submission to a Pax Americana. Put another way, American policy in the Middle East has devolved into unadorned state terrorism.
Michael Schwartz, Professor of Sociology and Faculty Director of the Undergraduate College of Global Studies at Stony Brook University, has written extensively on popular protest and insurgency, and on American business and government dynamics. His books include Radical Protest and Social Structure, and Social Policy and the Conservative Agenda (edited, with Clarence Lo). His work on Iraq has appeared on numerous internet sites, including Tomdispatch, Asia Times , Mother Jones, and ZNet; and in print in Contexts, Against the Current, and Z Magazine. His email address is email@example.com.
by Tom Engelhardt Keep in mind, I've run Tomdispatch.com for only a few years, but I've been a book editor in mainstream publishing for over 30...
by Tom Engelhardt Think of it as a Tomdispatch.com milestone. This is now the first website to "indict" the President, the Vice...
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Drug manufacturers must demonstrate the comparability of their products after process and formulation changes to ensure similar quality, safety, and efficacy. Biosimilars also require evaluation of their equivalency to the innovators' products. By complementing traditional biochemical methodologies, biophysical characterization, using a variety of methodologies, can enhance product knowledge in terms of higher order structure, molecular size distribution, and the properties of aggregates. This article presents three case studies that show the advantages of applying state-of-the-art biophysical techniques in comparability assessments.
This article presents three case studies, which show the advantages of applying biophysical techniques in product comparability assessments.


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Thursday, December 04, 2014
by Mike Adams, the Health Ranger
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Irving'e karşı Lipstadt
Defense Documents
David Irving, Holocaust Denial, and his Connections to Right Wing Extremists and Neo-National Socialism (Neo-Nazism) in Germany: Electronic Edition, by Hajo FunkeTable of Contents
|<< 5.3 1990: 'Truth Frees' [...
|< 5.1 1989: 'German histori...
|5.5 1991: 'the total cata... >
|5.9 1993: expulsion >>
5.4 OPC observations 1990.
5.4.1.The 1990 VSB reported that
The important British revisionist David Irving (52), who spoke at the 10-3-90 DVU rally in Passau was not allowed to speak because the town administration put a ban on the meeting. Nevertheless he could express his opinions at meetings of right-wing extremists in Munich, Dresden, Leipzig, Gera, Stuttgart, Weinheim/Bergstrasse, and Oberhausen. The Minister for the Interior ordered a ban on his entering the FRG. Irving was nevertheless not identified when he entered Germany, however, he distributes the Leuchter Report from London.315
5.4.2.In state VSBs it was observed that at several meetings that year Irving had stated the Holocaust was just a 'propaganda lie'.316 In Munich he was quoted as having said that there 'were never any gas chambers in Auschwitz'.317 Further 'The British writer David Irving also shared the conviction that the Holocaust is just a propaganda lie put about by the allies of World War II.'318 'Irving, in his books and lectures puts forth vehement opinions of the so-called revisionism that claims the Holocaust (gassing of deported Jews) did not occur.'319
315. Verfassungsschutz-Bericht 1990, p. 120
316. Verfassungsschutz-Bericht, Rheinland-Pfalz, 1990, p. 134.
317. Ibid., p. 296
318. Verfassungsschutz-Bericht, Niedersachsen, 1990, p. 27.


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Hillary Clinton Stands Firm on Benghazi
Don't look for Hillary Clinton to give much ground in the partisan feuding over the 2012 terrorist attack in Benghazi, Libya, in the event she runs for president.
Mrs. Clinton, in an interview with ABC News, made clear that while she bore responsibility as former secretary of state, she said she had also delegated the job of protecting the diplomatic facility to people with more training and expertise in such matters.
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Asked by ABC's Diane Sawyer if she had missed "the moment to prevent this from happening," Mrs. Clinton said: "No."
Could she have personally done anything to make conditions safer in Benghazi for the U.S. personnel stationed there? Ms. Sawyer asked.
Ms. Clinton said that she had given "very direct instructions " to security professionals, adding, "I'm not equipped to sit and look at blueprints to determine where the blast walls need to be or where the reinforcements need to be."
"That's why we hire people who have that expertise," she said.
ABC has been rolling out the interview with Mrs. Clinton in snippets over the past few days, but dedicated a full hour to Mrs. Clinton on Monday night.
Republicans see Benghazi as a potential obstacle to a Clinton presidential bid. GOP lawmakers contend that Mrs. Clinton missed warning signs that the compound in Benghazi was vulnerable to terrorist attacks.
More In 2016
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Mrs. Clinton, in the interview, previewed how she'll talk about Benghazi on the campaign trail if she decides to run. Se said Benghazi was one of a number of outposts located in dangerous parts of the world. And she noted that Ambassador Chris Stevens, one of the men killed, had chosen to serve in that post.
"It was important to have diplomatic assets," Mrs. Clinton said. "Were there security threats? Yes. And there's a long list of countries where there are security threats to American interests."
Mrs. Clinton sat for the interview as part of a high-profile rollout for her new book, "Hard Choices," which will be released on Tuesday. The book tour could serve as a trial run for a presidential campaign, giving her a chance to test out answers to anticipated questions and lines of attack.
In the coming weeks she will make a slew of public appearances and take part in interviews with all five of the major TV networks.
On Tuesday she is set to sign books at a Barnes & Noble store in New York City. The next day she is off to Chicago to take part in a forum moderated by Mayor Rahm Emanuel. On Friday she will sign books in Philadelphia and take part in an event in Washington, D.C.
The ABC interview also covered:
– Mrs. Clinton's age. She will be 69 years old when the election rolls around. Too old? Mrs. Clinton noted that her mother, Dorothy Rodham, lived an active live until her death at 92.
She said, "she was as active and involved and just curious and intellectually capable as people much younger than her."
So, age isn't necessarily a barrier, she suggested. It all depends "upon who the person is."
– Monica Lewinsky. Ms. Lewinsky recently published a piece in Vanity Fair magazine about the difficulty of creating a life for herself after she was exposed as Bill Clinton's mistress in the late-1990s.
Mrs. Clinton said, in reference to the article, "Well, she's perfectly free to do that. She is, in my view, an American who gets to express herself however she chooses. But that's, you know, not something that I spend a lot of time thinking about."
"Really?" Ms. Sawyer said.
"Really. Really, yes," Mrs. Clinton said.
– The Clinton family's wealth. Ms. Sawyer asked Mrs. Clinton about earning hundreds of thousands of dollars for paid speeches.
Mrs. Clinton said that when she and her husband left the White House in 2001 they had no money and had to scramble to buy houses and pay for daughter Chelsea's education.
"First of all, we had to pay off all our debts, which was — we had to make double the money because of obviously taxes and then pay off the debts and get us houses and take care of family members."
"But do you think Americans are going to understand five times the median income in this country for one speech?" Ms. Sawyer asked.
"Well, let me put it this way," Mrs. Clinton said. "I thought making speeches for money was a much better thing than getting connected with any one group or company, as so many people who leave public life do."
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An 83-year-old Rolla woman died from injuries she received from a car crash at 10th Street and Forum Drive in Rolla Monday night, according to the Rolla Police Department.
A press release from the department states that Marjorie M. Sterling was pronounced dead after she was transported to Phelps County Regional Medical Center by Phelps County Ambulance. Her next of kin were notified.
Rolla police were dispatched to the crash scene around 9:10 p.m. June 24. Rolla police said Sterling was driving a 2006 Chevrolet Impala southbound on Forum Drive and making a left turn from Forum Drive onto 10th Street when her vehicle was struck by a 2004 Hyundai Elantra driven by Megan N. James, 22, of Rolla, that was traveling northbound on Forum Drive toward 10th Street.
A passenger in the James' vehicle suffered a laceration to the right side of her head. She was transported to PCRMC, treated and later released.
James suffered minor injuries but was not transported, according to Capt. Jason Smith, of the RPD.
"We don't think anyone ran a red light," Smith said, but added that the investigation is continuing and that fault has not been determined. The RPD and Missouri State Highway Patrol are investigating.
The Hyundai sustained major front-end damage and front driver side damage, and both air bags were deployed.
The Chevrolet had major front-end damage and the front air bag was deployed.
Assisting the RPD at the crash scene were City of Rolla Fire and Rescue, Phelps County Ambulance, MSHP and the Phelps County coroner's office.
Location, ST | website.com


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Leonardo DiCaprio reportedly walked Kate Winslet down the aisle during her secret wedding to Ned Rocknroll.
Right -- it's stunning. Someone named themselves "Rocknroll." And it wasn't Tom Cruise's character in "Rock of Ages."
A source told Us Weekly that the bride's longtime friend and co-star of "Titanic" and "Revolutionary Road" had the honor of giving her away at her wedding earlier this month.
Winslet's rep confirmed the secret wedding ceremony, telling People magazine:
"I can confirm that Kate Winslet married Ned Rocknroll in NY earlier this month in a private ceremony attended by her two children and a very few friends and family. The couple had been engaged since the summer."
However, reps have not yet confirmed reports that DiCaprio walked Winslet down the aisle. So let's just assume it happened.
A rep for DiCaprio would not confirm that the actor was at Winslet and Rocknroll's wedding.
This is the third marriage for Winslet, who was previously married to Jim Threapleton from 1998 to 2001 and to director Sam Mendes from 2003 to 2010.
Of course, Ned Rocknroll is not his real name. The 34-year-old businessman was born Abel Smith, and he is the nephew of Virgin Group founder Richard Branson. He currently works for his uncle's company Virgin Galactic, which is the space-travel division of the Branson empire. Before his relationship with Winslet, Rocknroll was married to British socialite Eliza Pearson for two years.
Contact Tony Hicks at firstname.lastname@example.com or on Facebook at www.facebook.com/BayAreaNewsGroup.TonyHicks.


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LOS ANGELES -- The Democratic Party has controlled the California Legislature for a nearly unbroken stretch of 42 years. Yet control goes only so far: It takes two-thirds of the Legislature to enact a host of important legislation in this state, meaning that even the diminished Republican Party has been able to easily frustrate Democratic ambitions.
But with a swell of electoral victories in November, the Democratic Party has now crossed that boundary and controls two-thirds of both the Senate and the Assembly, giving it the kind of unfettered power that no party has had here for 80 years.
This does not appear to be a passing advantage. Even Republicans say that changes in electoral demographics mean that, with the exception of a few brief lapses caused by vacancies, Democrats could hold a supermajority at least through the end of the decade.
Yet in the "be careful what you wish for" department, Democrats are beginning to confront the struggles and complications that come with being in charge of the store. This authority came at least two years earlier than most Democrats had projected. And it is unleashing years of pent-up Democratic desires -- to roll back spending cuts, approve a bond issue to rebuild the state's water system, amend the state's tax code, revamp California's governance system -- that had been largely checked by the Republican minority.
At the same time, it is stirring concerns from Democrats, among them Gov. Jerry Brown, that the situation may inspire an overreach that could make the party's reign brief. By contrast, some Democrats argue that handled correctly, the next two years could provide an opportunity to lock in long-term control.
"The center of gravity of the Democratic Party will be restraint, but some people can't help themselves," Brown said in an interview. "The supermajority is not a permanent condition. It's something that can be lost far more easily than it can be gained."
The demand become apparent even before the new Legislature was sworn in this month. State Sen. Ted W. Lieu, a Democrat, proposed reinstating an automobile registration fee that was repealed under Gov. Arnold Schwarzenegger. That fee was a rallying point of what many saw as excessive taxation here; its elimination created a $4 billion revenue shortfall. Lieu pulled back at the urging of Democratic leaders.
Darrell Steinberg, the president pro tem of the Senate, said that he appreciated the risks and that Democrats would not overstep. "We get the overreach warning: We have heard it, and we acknowledge it," Steinberg told lawmakers at their swearing-in ceremony. "But frankly, I think you can focus too much on overreach because there is an equally compelling danger. It is the danger of being so cautious, so worried about creating controversy, that we fail to take advantage of unprecedented opportunities."


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The St. Louis Cardinals traveled light to Chicago leaving their bats behind in Milwaukee. The Cardinals who beat up on a very good Brewers team were only able to score one run against a very bad Cubs team. The two teams are tied in the second inning as of this writing. The Cardinals have another day off tomorrow before coming home to begin a weekend series against the Colorado Rockies who have been one of the surprise teams in baseball this year.
The Kansas City Royals lost a tough extra innings game to the Chicago White Sox on Monday afternoon before losing at Baltimore to the Orioles last night. They continue their series tonight.
After combining to score seven goals total in the first three games of their series the St. Louis Blues and Los Angeles Kings combined to score seven goals in one game on Monday night as the Blues lost a tough one to the Kings 4 to 3. The series is now all knotted up at 3 with game 5 tonight in St. Louis. This has been a very hard hitting series so far with the Kings being an extraodinarily physical team and the Blues having to try to match up against that. So far the teams have yet to lose a game at home so this series may go the full seven games.
In a sign there is still justice in the world the Miami Heat will not be able to make a clean sweep on their way to the NBA finals as the Chicago Bulls were able to win the first game of their NBA Eastern Conference semifinal game against the Heat on Monday. It was nice to be reminded the Heat are not invincible much to the chagrin of most of the people who work at ESPN.
Congratulations to the Kirksville High School girls track team who won the NCMC conference track meet on Monday by twenty points. The KHS boys track team also had several individual winners. Both teams head to districts this Saturday at Mexico. This is supposed to be the toughest district in the state so making it through districts almost ensures a top finish at state. I look for both KHS track teams to do very well on Saturday.
The KHS boys tennis team have done well in district competition so far as they defeated Moberly yesterday.
We'll be back on Friday with a more thorough bog previewing all this weekend's sports action. Thanks as always for reading and please check out all the blogs on this site.
Have a wonderful Wednesday!


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N +18º 25' 7.82" / W -65º 47' 33.71"
Tel: (1) 787 8091770Fax: (1) 787 8091785
Check-in after 16:00h
Check-out until 11:00h
Gran Meliá Golf Resort Puerto Rico is a highly sophisticated architectural gem nestled on Puerto Rico's northeastern coast in Coco Beach, Río Grande. Gran Meliá Golf Resort Puerto Rico brings the privacy and exclusivity you deserve, and allows you the opportunity to escape from the rest of the world. Just a scenic 30 minutes from Luis Muñoz Marín International Airport and the greater San Juan.
On a lush peninsula 19 miles from San Juan, Gran Meliá Puerto Rico delivers a bold new statement on the nature of hospitality. Discover the tropics anew with Gran Meliá's signature RedGlove ServiceSM as your guide.Against the backdrop of El Yunque rainforest, the villas and pavilions of Gran Meliá rise from an oceanfront landscape of gardens, pathways and pools. Structure your days around championship golf on two adjacent courses or the multi-court tennis center. Lounge poolside or indulge in the renowned YHI Spa. Whatever your desire, you can depend on RedGlove Service to help you make the most of your stay.


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Idiopathic anaphylaxis (IA) is a condition in which anaphylaxis occurs without any known external trigger. The most common causes of anaphylaxis are reactions to foods, drugs, and stinging insects, but a cause is not identified in up to 50 percent of people with recurrent anaphylaxis. Volunteer participants in this study will help National Institutes of Health (NIH) researchers try to identify the cause and development of IA. Findings from this study may be a first step toward the development of new medicines and treatments.
If you have been diagnosed with idiopathic anaphylaxis and are interested in participating in this clinical research study, you will be asked to answer some questions and then make one or two visits to NIH in Bethesda, Maryland, to determine your eligibility. During these visits, study staff will take a sample of your blood. They also may take a sample of bone marrow from your hip. Your participation in the study will continue for up to 12 months, the first six months of which you will receive the study drug every two or four weeks in a randomized placebo-controlled trial (you may or may not receive the active drug, and this is determined similar to a coin toss). You may receive a thorough medical evaluation to exclude known causes of anaphylaxis, if necessary. You or your insurance carrier will not be charged for study-related procedures or medications.
The study is being conducted at the NIH Clinical Center in Bethesda, Maryland, which is accessible by car and public transportation. After you are accepted in the study, you may be reimbursed for your travel expenses.
You may be able to participate in the study if all of the following apply to you:
You cannot participate in the study if any of the following apply to you:
To learn more about this study, visit www.clinicaltrials.gov.
Toll free: 1-800-411-1222TTY: 1-866-411-1010Se habla Español.
Last Updated April 09, 2013
Last Reviewed February 13, 2015


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Atlas Genetics raises £16.9m for market entry of Chlamydia-diagnostics
Bristol – Atlas Genetics has raised £16.9m from a syndicate of new and existing investors led by Novartis Venture Funds, and Consort Medical plc. The series B round will be drawn down over three years to help to commercialize infectious disease tests, especially the global launch of the Velox diagnostic-kit for Chlamydia and gonorrhea. Commercial launch of the system is planned for 2012. The money will also be used for the development of other infectious disease tests and to expand the immunoassay capability of the Velox system.
Velox is a point of care-diagnostic system for a broad range of infectious diseases using either nucleic acid or immuno-assays. Atals's CEO John Clarkson commented: "We are delighted to welcome the new investors at this time when the company's first productn is being transferred to manufacture and the core capabilities of the sensor chemistry are being expanded."
The new investors in this series B financing are Novartis Venture Funds, LSP (Life Sciences Partners), BB Biotech Ventures and Johnson & Johnson Development Corporation. The newly announced financing follows a £1.5 million round in February 2011 supported by Consort Medical plc and other investors. The Company has been funded previously, and continues to be supported, by YFM Equity Partners, Braveheart Investment Group, Wyvern Asset Management, the Crescent Seedcorn Fund and private investors.


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See images from Himawari-8 in the new satellite viewer
This demonstration product is most suitable for people
with fast internet connection and high data allowance.
Low-definition satellite images
Satellite View Selection
02:00 ACST on Thursday 25 August 2016 | Cloud/surface composite, Australia
Images from Japan Meteorological Agency satellite Himawari 8 via Bureau of Meteorology.
IDY28000 Australian Government Bureau of Meteorology Bureau National Operations Centre Satellite Notes for the 1200UTC Chart on 24 August 2016 Issued at 11:00 pm EST Wednesday on 24 August 2016 A surface trough and associated upper level trough are generating a cloud band that covers most of the eastern seaboard and extends out over the Tasman Sea towards New Zealand. A weakening low pressure system over the Bight is generating areas of cloud over South Australia and southern coastal areas of Western Australia. Cloud associated with a strong cold front lies well to the west of WA. Patchy low and middle level cloud associated with a low pressure trough covers parts of Tasmania.