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Finding a Safe and Effective Dose of Linagliptin in Pediatric Patients With Type 2 Diabetes
This study has been completed.
Boehringer Ingelheim
Eli Lilly and Company
Information provided by (Responsible Party):
Boehringer Ingelheim
ClinicalTrials.gov Identifier:
First received: April 26, 2011
Last updated: February 16, 2016
Last verified: February 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The main objective of this study is to identify the dose of linagliptin in paediatric patients.
Other efficacy objectives include the comparison of the lowering effect of linagliptin low dose, high dose and placebo on the fasting plasma glucose (FPG) observed after 12 wk of treatment.
Furthermore, the study will investigate the pharmacokinetics (PK), the pharmacodynamics (PD) and the PK/PD relationship of linagliptin in the paediatric population.
Diabetes Mellitus, Type 2
Drug: placebo
Drug: BI1356 low dose
Drug: BI1356 high dose
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
|Official Title:
|A Randomised, Double-blind, Placebo-controlled, Parallel Group Dose-finding Study of Linagliptin (1 and 5 mg Administered Orally Once Daily) Over 12 Weeks in Children and Adolescents, From 10 to 17 Years of Age, With Type 2 Diabetes Mellitus
Resource links provided by NLM:
MedlinePlus related topics: Diabetes Type 2
Drug Information available for: LinagliptinU.S. FDA Resources
Further study details as provided by Boehringer Ingelheim:
Primary Outcome Measures:
- The primary efficacy endpoint in this trial is the change from baseline in Glycosylated Haemoglobin (HbA1c) (%) after 12 weeks of treatment [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- The secondary efficacy endpoint is the change from baseline in fasting plasma glucose (mmol/L) after 12 weeks of treatment [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
- The key secondary endpoint in this trial is DPP-4 inhibition (%) at trough at steady state [ Time Frame: 4 weeks or 8 weeks or 12 weeks ] [ Designated as safety issue: No ]
|Study Start Date:
|April 2011
|Study Completion Date:
|February 2016
|Primary Completion Date:
|February 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: linagliptin low dose
linagliptin low dose for children once daily
Drug: BI1356 low dose
comparison of different dosages of drug (low vs high) vs placebo
Experimental: linagliptin high dose
linagliptin high dose for children once daily
Drug: BI1356 high dose
comparison of different dosages of drug (low vs high) vs placebo
Placebo Comparator: placebo
matching placebo for each linagliptin dose once daily
Drug: placebo
comparison of different dosages of drug (low vs high) vs placebo
|Ages Eligible for Study:
|10 Years to 17 Years (Child)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion criteria:
- Paediatric patients (children and adolescents), aged 10 to 17 years with documented diagnosis of type 2 diabetes mellitus
- Insufficient glycaemic control (i.e. an HbA1c > 6.5% and <= 10.5%) despite treatment with diet and exercise and/or metformin (>= 1000 mg per day (or the maximum tolerated dose) at a stable dose or dosing frequency for 8 weeks prior to randomisation) and/or concomitant stable basal insulin (total daily dose must be <= 0.5U/kg with less than 10% of weekly dose change for 12 weeks prior to randomisation)
- Negative for islet cell antigen (ICA) auto-antibodies and glutamic acid decarboxylase (GAD) auto-antibodies
- C-peptide levels (serum) >= 1.5 ng/ml (at 90 min following a Boost challenge)
Exclusion criteria:
- History of acute metabolic decompensation, such as diabetic ketoacidosis, within 3 months
- Current short-acting insulin or having received short-acting insulin for more than 3 days within 1 month prior to randomisation
- Treatment with weight reduction medications (including anti-obesity treatments)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01342484
Show 32 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01342484
Show 32 Study Locations
Sponsors and Collaborators
Boehringer Ingelheim
Eli Lilly and Company
|Study Chair:
|Boehringer Ingelheim
|Boehringer Ingelheim
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 29, 2016
|Responsible Party:
|Boehringer Ingelheim
|ClinicalTrials.gov Identifier:
|NCT01342484 History of Changes
|Other Study ID Numbers:
|1218.56 2009-017004-91
|Study First Received:
|April 26, 2011
|Last Updated:
|February 16, 2016
|Health Authority:
|Canada: Health Canada
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Guatemala: Ministry of Public Health and Social Assistance
Italy: Ethics Committee
Mexico: Federal Commission for Protection Against Health Risks
Poland: Registration Medicinal Product Medical Device Biocidal Product
Russia: Pharmacological Committee, Ministry of Health
South Korea: Ministry of Food and Drug Safety (MFDS)
United States: Food and Drug Administration
Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on August 29, 2016


text:
Here it is.
Also, like I said, when playing SD file, it's no video - it came out, that is uses old MEncoder - I sorted that one out - just deleted every exe and put only the new one. It was my mistake from the begining, sorry
But the subtitles problem remains - I found out that it has problems with subs inside mkv, external are fine (but they're losing its formatting, .ass ones, which is pretty bad).
btw. Is there a way to use DirectVobSub with MEncoder but without AviSynth?

subset: commoncrawl


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How to Manage Your PMS Like a Boss
For starters, working out is kind of like having sex. You need some foreplay, a.k.a. a warm up, before you get started. Miller recommends starting off in push up position. Starting with the right leg, kick your leg under your body and out to the side, opening up your hips. Cross your right leg under your torso, kicking it out to the opposite side and opening up your hips. Straighten your leg and keep it as high as possible, not touching the floor. Alternating legs, do this exercise for one minute before moving on to your workout.
From the push up position, drop down to your knees so that you're on all fours. Lift the right leg out to the side, keeping it straight at a 90-degree angle. Point your toe and lift your right leg up and down for one minute. Lightly touch the floor with your toes. Repeat on the left side.
Starting in the same position as the Doggie, hold your right leg straight out at 90 degrees, keeping your foot in line with your hip and slowly circling forward for 30 seconds. Switch and circle backwards for 30 seconds. Note: These should be tiny to small circles. Repeat on the left side.
6 Ways to Stop Your Computer From Harming Your Health


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Posts Tagged 'Sensitive Santa'
Glimcher Realty Trust Announces Sensitive Santa® Holiday Photo Event for Children with Autism
November 30, 2011 1 comment
On Sunday, December 4, 2011 at select Glimcher malls, the Santa area will reserved just for children with autism. The Santa area will be "sensory friendly," with lower lighting and quieter surroundings. The events will be held before the malls open to shoppers with a free Santa photo and festive giveaways.
Sensitive Santa® Events to be held at the following Glimcher properties on Sunday, December 4:
The Sensitive Santa® event at Merritt Square Mall in Merritt Island, Florida will take place on Sunday, December 11 from 7:00am-9:00am.
If you or someone you know might have a child that would enjoy one of these events, contact Glimcher Marketing Director, Jessie Fausett at email@example.com.
Categories: Awareness autism, Autism Speaks, Christmas, Santa, Sensitive Santa


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Miranda Jack, Lecturer
College of Arts and Sciences 360
Professor Jack teaches English 300: An Introduction to Professional Writing and CORE 110/115. In the spring of 2012, Professor Jack joined the Books and Coffee committee and enjoyed presenting her own book review. She is also an adjunct instructor at Ivy Tech Community College in Valparaiso, and teaches two sections of English 111: Freshman Composition I. Professor Jack admits that both teaching positions continually teach her more about her field as well as her students, which is something she loves about her job.
Before teaching at Valparaiso University, Professor Jack worked as an English teacher with both seventh and eleventh grade students in Colorado Springs, Colorado, and has a Colorado secondary teaching license. She was also a full-time pre-school teacher at Hilltop Neighborhood House in Valparaiso, Indiana. This wide range of teaching experience helps her to create different classroom activities and discussions to engage students of all ages.
In her spare time, Professor Jack enjoys watching films, traveling, reading, exercising, and spending time with her family.
M.A. - Valparaiso University, B.A. - University of Colorado at Colorado Springs


text:
Visit Sardinia, Italy
Addis Ababa, Texas, Ethiopia
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text:
Listed below are answers to frequently asked questions. For assistance, contact the Office of Registration and Records.
Last updated: 16 August 2016
The Catalog of Indiana State University is the document of authority for all students. The requirements given in the Catalog supersede information issued by any academic department, program, college, or school. The University reserves the right to change the requirements at any time. The right to correct errors is also reserved.
Office of Registration and Records
Parson Hall 009
200 North 7th Street
Indiana State University
Terre Haute, IN 47809
(812) 237-2020


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Make a splash at lunchtime and try making this fin-tastic version of the classic peanut butter and jelly sandwich.
Weekdays on NICK
Spoon the peanut butter and jelly into separate plastic resealable bags. Press out the excess air and seal the bags completely.
Using an oval-shaped cookie cutter, cut out four 3 1/2-inch and four 1 1/2-inch ovals from the bread slices. Cut four 1 1/2-inch triangles from the scraps to make the fins.
Snip a small (1/4 inch) corner from each of the bags with the peanut butter and jelly. Squeeze some of the peanut butter, then jelly onto one slice of bread. Add a top slice to complete the sandwich. Cut the small ovals in half lengthwise to make the fins.
Using the photo as a guide, arrange the pieces on serving plates and use the large piece for the body, the half ovals for the fins on top and bottom of body, and the triangle piece for the fins. Pipe a few squiggly lines of peanut butter and jelly on top of the sandwich as scales and fins. Pipe a few lines on the plate. Add the dark raisin for the eye and the golden raisins as the bubbles.
Kids will have fun in the kitchen making these bubble bites just right!
A swimsational spread that will keep kids dipping back into the kitchen for more of this fish cracker snack!
Something is fishy about these snacks� but kids won't suspect that a tasty treat could also be healthy!
Fishin' for a quick and easy treat for your Bubble Guppies fan?
Go fishing for fruit--and make a game out of good eating!
Bubble Guppies fans will dive right into this tasty dip!
What's hiding under that sheet? One fin-tastic treat!
Make them smile with a sweet Guppies treat!
A frozen drink that looks like Gil's tail? COOL!
Little guppies will flip for this funny take on dessert!
These swim-sational cookies will pop right out of your cookie jar!
Make no bones about it, these cookies are delicious & easy to make!
Make a fin-tastic sandwich that looks like your kid's favorite preschool teacher
Bake the cake and top it off with Molly and Gil!
These fetchin' cupcakes will stand out at your little guppy's next party!
Turn plain pound cake into bite-sized cake pops that look like Little Fish!
Make a splash at snack time with a swimsational veggie treat!
What time is it? It's time for a new twist on classic macaroni and cheese!
Make this tasty treat any day of the week--it's simple!
Kids will want s'more of this chocolate and marshmallow-filled treat!
All aboard! Kids won't even notice the veggies on this healthy pizza
Turn a hot dog into a...hot "DOG!"
Frowns turn friendly fast with this easy 5-step pizza!
Here's a mighty healthy lunch idea--go on, take it for a spin!
Make a sandwich look just like Peppa!
Make a fin-tastic sandwich that looks like your kid's favorite preschool teacher
Your Umi fan will say 'Great Gigabytes' when you make this avocado & cheese sandwich
Make a mighty cute sandwich for your little Milli fan
Make a super cream cheese sandwich for your hungry Umi fan!
Make this a-DORA-ble sandwich for your sweetheart!
What time is it? It's time for a new twist on classic macaroni and cheese!
Make some-bunny smile with this cute & healthy lunch
Turn a hot dog into a...hot "DOG!"
Kids will get a kick out of making Boots from bread and bologna!
Your little star will love exploring this healthy pasta salad!
Share this snack with your little explorers. They're sure to swipe it right off the kitchen table!
Ham it up for lunch!
Please your little one with little bites of pizza
Look no further for a simple yet zesty pizza sauce
There's a surprise inside these triangle-shaped pizza snackers
These towers are a surefire way to get those veggies in
Serve up Mediterranean flavors in this pizza on a pita
Serve up some new flavors with this quick and easy recipe
Delivery? No, delicious!
Hooray--it's pizza night!


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- Incorporate quickness
- Currently Unavailable
with Chris Doyle,
University of Iowa Football Strength & Conditioning Coach
Foot speed and agility are critical to success in all sports. Winning with Fast Feet will teach you how to incorporate quickness and agility for all levels of athletes. Doyle strives to make the training fun by utilizing a variety of drills that keep athletes interested. Improve body control, reduce injuries and gain an edge over your competition with Fast Feet.


text:
Like any appliance, sometimes you may experience problems with how it works. Here are the most common problems associated with washer ...
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It is important to know that the dryer function on combo units use condensation drying since they are ventless. This means that clothes may feel damp to the touch upon completion of the dry cycle, but will quickly air dry. These units are ideal for customers who do not have the space for full size units, or lack laundry connections, but do not want to have to make routine trips to the Laundromat.
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text:
About the Book
Venice, a long time ago. Three prominent Venetians await their most loathsome and foul dinner guest, the erstwhile envoy from the Queen of Britain: the rascal-Fool Pocket.
This trio of cunning plotters—the merchant, Antonio; the senator, Montressor Brabantio; and the naval officer, Iago—have lured Pocket to a dark dungeon, promising an evening of sprits and debauchery with a rare Amontillado sherry and Brabantio's beautiful daughter, Portia.
But their invitation is, of course, bogus. The wine is drugged. The girl isn't even in the city limits. Desperate to rid themselves once and for all of the man who has consistently foiled their grand quest for power and wealth, they have lured him to his death. (How can such a small man, be such a huge obstacle?). But this Fool is no fool . . . and he's got more than a few tricks (and hand gestures) up his sleeve.
Greed, revenge, deception, lust, and a giant (but lovable) sea monster combine to create another hilarious and bawdy tale from modern comic genius, Christopher Moore.
New York Times bestselling author Christopher Moore channels William Shakespeare and Edgar Allan Poe in this satiric Venetian gothic featuring the irresistibly mischievous Pocket of Dog Snogging, the eponymous hero of Fool
Venice, a really long time ago. Three prominent Venetians await their most loathsome and foul dinner guest, the erstwhile envoy from Britain who also happens to be a favorite of the Doge: the rascal-Fool Pocket.
This trio of cunning plotters—the merchant, Antonio; the senator, Montressor Brabantio; and the naval officer, Iago—have lured Pocket to a dark dungeon, promising a spirited evening with a rare Amontillado sherry and a fetching young noblewoman. Their invitation is, of course, bogus. The wine is drugged; the girl is nowhere in sight. These scoundrels have something far less amusing planned for the man who has consistently foiled their quest for power and wealth. But this Fool is no fool . . . and the story is only beginning.
Once again, Christopher Moore delivers a rousing literary satire, a dramedy mash-up rich with delights, including (but not limited to): foul plots, counterplots, true love, jealousy, murder, betrayal, revenge, codpieces, three mysterious locked boxes, a boatload of gold, a pound of flesh, occasional debauchery, and water (lots of water). Not to mention a cast Shakespeare himself would be proud of: Shylock; Iago; Othello; a bunch of other guys whose names end in "o"; a trio of comely wenches—Desdemona, Jessica, Portia; the brilliant Fool; his large sidekick, Drool; Jeff, the pet monkey; a lovesick sea serpent; and a ghost (yes, there's always a bloody ghost).
Wickedly witty and outrageously inventive, The Serpent of Venice pays cheeky homage to the Bard and illuminates the absurdity of the human condition as only Christopher Moore can.
Educator and Librarian Resources
Critical Praise
"Shakespeare and Poe might be rolling in their graves, but they're rolling with laughter. Christopher Moore is one of the cleverest, naughtiest writers alive." — Carl Hiaasen, New York Times bestselling author of a whole bunch of excellent books, including Bad Monkey, Nature Girl, and Sick Puppy on THE SERPENT OF VENICE
"Fans who enjoyed the rollicking play within a play of Fool or the historical whimsy of Sacré Bleu will find many of the same gifts here . . . from one of America's most original humorists." — Kirkus Reviews on THE SERPENT OF VENICE
"Fans of Fool will be overjoyed to rejoin Pocket and company . . . for their latest adventure, and newcomers will find that Shakespeare isn't nearly as dry and dusty as they thought, at least not when Moore is at the helm. — Library Journal (starred review) on THE SERPENT OF VENICE
"Moore's imaginative storytelling, bawdy prose, puns aplenty . . . succeed in transforming two classical tragedies into outrageously farcical entertainment." — Publishers Weekly on THE SERPENT OF VENICE
Moore's greatest asset is his skill with language. Readers with a certain Monty Python nerdiness will rejoice in its hundreds of insults . . . and jokes. . . . [W]itty and wise . . . Serpent is a bright, quick novel." (3 out of 4 stars) — USA Today on THE SERPENT OF VENICE
"The dialogue is extremely witty, and . . . you will laugh hard and find yourself hurling bawdy insults throughout the day, even if you don't say them out lout." — Louisville Courier Journal on THE SERPENT OF VENICE
"Moore . . . is an excellent writer, and there are passages of prose—Pocket's defense of Othello and the entire Pound-of-Flesh trial—that sparkle with Moore's trademark wit and intelligence. Moore's strength is his ability to appropriate supporting characters and make them wholly his own creations. — Dallas Morning News on THE SERPENT OF VENICE
"To get a sense of the tone, imagine the merry pranksters of Monty Python in their heyday taking off on Shakespeare while simultaneously trying to break the record for F-bombs currently held by The Wolf of Wall Street." — Tampa Bay Times on THE SERPENT OF VENICE
"A gleeful and wonderfully strange mash-up. Shakespeare's The Merchant of Venice, and Othello are its chief ingredients, with Edgar Allan Poe's short story 'The Cask of Amontillado' thrown in. The result? An imaginative, wildly inspired satire." — Seattle Times on THE SERPENT OF VENICE
"[Moore] brings back one of his favorite characters, Pocket from 2009's Fool. . . . Add a weirdly satisfying combo of literary in-jokes and low sex gags to the mix and what comes out of the Christopher Moore meat grinder is unique and sublime." — Fort Worth Star-Telegram on THE SERPENT OF VENICE
"The Serpent of Venice is a remarkable reimagining of classic literature, churned through historical backgrounds and research and set to a different drum. Tragedy becomes comedy in this side-splitting, hair-raising adventure. . . . A piece of literary gold." — Bookreporter.com on THE SERPENT OF VENICE
Product Details
- Imprint: William Morrow
- On Sale: 04/22/2014
- Pages: 352
- List Price: 7.99 USD
- BISAC1: FICTION / Humorous / General
- BISAC2: FICTION / Historical
- BISAC3: FICTION / Mystery & Detective / General


text:
About the Book
"Expect miracles when you read Ann Patchett's fiction."—New York Times Book Review
Award-winning, New York Times bestselling author Ann Patchett returns with a provocative and assured novel of morality and miracles, science and sacrifice set in the Amazon rainforest. Infusing the narrative with the same ingenuity and emotional urgency that pervaded her acclaimed previous novels Bel Canto, Taft, Run, The Magician's Assistant, and The Patron Saint of Liars, Patchett delivers an enthrallingly innovative tale of aspiration, exploration, and attachment in State of Wonder—a gripping adventure story and a profound look at the difficult choices we make in the name of discovery and love.
Ann Patchett has dazzled readers with her award-winning books, including The Magician's Assistant and the New York Times bestselling Bel Canto. Now she raises the bar with State of Wonder, a provocative and ambitious novel set deep in the Amazon jungle.
Dr. Marina Singh, a research scientist with a Minnesota pharmaceutical company, is sent to Brazil to track down her former mentor, Dr. Annick Swenson, who seems to have all but disappeared in the Amazon while working on what is destined to be an extremely valuable new drug, the development of which has already cost the company a fortune. Nothing about Marina's assignment is easy: not only does no one know where Dr. Swenson is, but the last person who was sent to find her, Marina's research partner Anders Eckman, died before he could complete his mission. Plagued by trepidation, Marina embarks on an odyssey into the insect-infested jungle in hopes of finding her former mentor as well as answers to several troubling questions about her friend's death, the state of her company's future, and her own past.
Once found, Dr. Swenson, now in her seventies, is as ruthless and uncompromising as she ever was back in the days of Grand Rounds at Johns Hopkins. With a combination of science and subterfuge, she dominates her research team and the natives she is studying with the force of an imperial ruler. But while she is as threatening as anything the jungle has to offer, the greatest sacrifices to be made are the ones Dr. Swenson asks of herself, and will ultimately ask of Marina, who finds she may still be unable to live up to her teacher's expectations.
In a narrative replete with poison arrows, devouring snakes, and a neighboring tribe of cannibals, State of Wonder is a world unto itself, where unlikely beauty stands beside unimaginable loss. It is a tale that leads the reader into the very heart of darkness, and then shows us what lies on the other side.
Educator and Librarian Resources
Critical Praise
"An engaging, consummately told tale." — New York Times
"Emotionally lucid. . . . Patchett is at her lyrical best when she catalogues the jungle." — The New Yorker
"This is surely the smartest, most exciting novel of the summer." — Washington Post
"The Amazon setting is something Patchett does rather marvelously.… The book is serious, but also so pleasurable that you hope it won't end." — NPR
"Outlandishly entertaining…[with] a brilliantly constructed plot." — Elle
"Packs a textbook's worth of ethical conundrums into a smart and tidily delivered story. . . . Ms. Patchett presents an alluring interplay between civilization and wilderness, between aid and exploitation." — Wall Street Journal
"The large canvas of sweeping moral issues, both personal and global, comes to life through careful attention to details, however seemingly mundane—from ill-fitting shoes and mosquito bites to a woman tenderly braiding another woman's hair." — O, the Oprah Magazine
"A spellbinder from bestselling author Patchett. . . . Thrilling, disturbing and moving in equal measures—even better than Patchett's breakthrough Bel Canto." — Kirkus Reviews (starred review)
"A superbly rendered novel. . . . Patchett's portrayal is as wonderful as it is frightening and foreign. Patchett exhibits an extraordinary ability to bring the horrors and the wonders of the Amazon jungle to life, and her singular characters are wonderfully drawn. . . . Powerful and captivating." — Library Journal (starred review)
"A thrilling new novel. . . . The world imagined in this novel is unusually vivid. . . . Reading State of Wonder is a sensory experience, and even after it's over you'll keep hearing the sounds of insects, and your own head will still be hot." — MORE Magazine
"Patchett makes the jungle jump off the page…This is Patchett's best effort since The Patron Saint of Liars and, yes, that includes Bel Canto" — Shelf Awareness
"Extraordinary. . . . Is there nothing the prodigiously talented Ann Patchett can't do? . . . Patchett's last knockout pages proceed full-speed ahead, with more twists and turns and trachery than the Amazon River. Nothing is as it seems, and the ending is as shocking as it's satisfying." — Boston Globe
Product Details
- Imprint: Harper
- On Sale: 06/07/2011
- Trimsize: 6 in (w) x 9 in (h) x 1.17 in (d)
- Pages: 368
- List Price: 26.99 USD
- BISAC1: FICTION / General


text:
Women's game begins at 5:30 p.m., with the men's game following at 7:30 p.m.
Its Good vs. Evil Night in the student section. Come dressed as your favorite super hero … or villain for this battle of good vs. evil! Batman, the Joker, Poison Ivy, or even a Ninja Turtle


text:
It was my privilege to have worked with or for John for 27 of his 28 years at NIAID. Although his influence on public health research was felt throughout many agencies, I would like to recall a few of experiences of his day-to-day colleagues at the NIH, which number in the hundreds, and, especially, those in the Division of Microbiology and Infectious Diseases of NIAID, which he directed for a decade.
Twenty-eight years with one unit seems to be a very long time these days, but really experienced hands in research and public health will tell you that there is no substitute for tenure in successful programs. If success is measured by how many good ideas actually get implemented, time is a critical factor. But this is not about new ideas. All successful programs in our line of work have novel concepts. It's about the messenger. People don't really pay attention to you for the first ten years, and after that apprenticeship, you are trusted, you get a seat at the table and your influence grows. John logged the time required at one location to establish a remarkable career in public service with wide-ranging impact. His tenure at NIAID was a tremendous asset in having our ideas considered, and, more importantly for these remarks, it was the foundation of a wealth of long-lasting friendships.
Ideas are important in our line of work, of course, but John also valued the person with the ideas and those who implemented them. In their recollection of John, nearly all of his colleagues mentioned first their personal connection with him. This was true whether the relationship was occasional and strictly programmatic or regular and more routine. Everyone feels the loss personally because they felt a personal connection with John. And he stayed in touch, even long after separations from promotions and reassignments. For instance, years after he learned a bit of baseball trivia in a chance conversation and after he left DMID to become Deputy Director, he sent one of the staff an email – unsolicited and completely out of the blue - with a reproduction of the baseball card of her great uncle, Edward Abbatichio, who was a Pittsburgh Pirate teammate of Honus Wagner. Thanks to John, a color copy of the card is on her sons's bedroom wall, and a family legacy was burnished. Such long-distance contacts were not unusual, and they demonstrate the personal touch that characterized John. Most of the people in this room could relate a similar story.
Admittedly, John's style of management was a little mysterious – but effective. He carefully considered new initiatives and new ideas, but exactly how he set priorities was never spelled out entirely. Once, John stopped by personally to tell the chief of the respiratory diseases branch, apparently after careful consideration, that he had approved her major new initiative. His management mystique was only reinforced by the fact that he stopped by to pass along this critical information on his way to the rest room. Apparently, "location, location, location" applies to office space as well as real estate. And when the Department sent around its occasional reminder to improve the syntax of government memos, we heard that some managers were actually editing outgoing memos. John's approach was different. He gave everyone their very own copy of Strunk and White's "Elements of Style". I suspect that John's approach had a more lasting effect.
But John had many roles to play in addition to directing infectious disease and microbiological research. He and Elaine were aspiring farmers, too, and tales of John's attempt to tame the wilderness of Loudon Country are legendary. The gist of this vast oral tradition lore is that he was more adept, apparently, at research programming than he was at weed-whacking. And his rural land-use disputes with beavers took several years to resolve, and none too peacefully, either. The beaver's skull is on display in a DMID office.
And John was a baseball nut. He was always going-on about his beloved Pirates. But baseball taught him a lesson about government ethics. In 1979 John asked me to accompany him on a site visit to the influenza research program at the University of Washington where John Fox and Hjordis Foy ran a long-standing, successful community respiratory disease project. After weeks of negotiating calendars and many weeks before the trip, John discovered that the All-Star Game that year would be played in Seattle during our visit. At first he talked enthusiastically about getting tickets, and then he started to worry about the appearance of a conflict of interest. And, man, how he could worry! To hear him tell it, he was convinced that we would be sitting next to Jack Anderson. He was convinced that someone would think that we had arranged the visit so we could go to the game. Imagine! But John always counseled taking the High Road. He knew that appearance of conflict trumps personal interests, and he was terribly disappointed to be caught between love of baseball and the ethical High Road. Disappointment faded quickly, however, when Pirate all-star outfielder Dave Parker gunned down the go-ahead run trying to score from second on a single. He jumped straight up out of his seat at the King Dome! Baseball had trumped appearance - at least for nine innings a quarter-century ago.
Speaking for many, many NIH staff, we will miss John.
Last Updated March 17, 2005


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Opening a new front in Silicon Valley's latest arms race, the Chinese Internet company Baidu said Friday that it has hired former Google and longtime Stanford researcher Andrew Ng as chief scientist to run its artificial intelligence research labs in Sunnyvale and Beijing.
Ng, who is also co-founder of the online education company Coursera, is a highly regarded computer scientist who worked on artificial intelligence projects at Google's secretive X division, where he helped create a "neural network" of computers that famously taught itself to recognize images of cats by analyzing thousands of YouTube videos.
The hire is a significant coup for Baidu, which operates China's leading Internet search engine. The company has not indicated any plans to enter the U.S. market, but it has followed the lead of other major foreign tech firms by opening a research office in Silicon Valley -- where it hopes to tap the region's talent pool and gain more prominence within the tech industry.
Ng's move is another sign that leading Internet companies are pouring resources into artificial intelligence research, which they believe will help them deliver more personalized online services and advertising. As this newspaper reported last month, Facebook, Google and other top companies have been vying to acquire top talent in the field by buying smaller companies and hiring leading university researchers.
"Andrew is the ideal individual to lead our research efforts as we enter an era where AI plays an increasingly pronounced role," Robin Li, the chief executive of Baidu, said in a prepared statement that hailed Ng as "a true visionary and key contributor to the field of artificial intelligence."
While artificial intelligence is a broad term, it generally refers to sophisticated computer systems that can analyze vast amounts of data and learn to identify items or even anticipate outcomes. Ng is known for pioneering work in a field known as "deep learning," in which massive computer networks solve complex problems without being told directly what to do at every step of the process.
"Deep learning is a superpower: You can write software to ingest data and produce knowledge," Ng joked during remarks at the opening of Baidu's new offices. "I often go to sleep thinking about deep learning. What could be more exciting than that, to build intelligent machines?"
Baidu established a "Deep Learning Institute" last year, with a small office in Cupertino. With the hiring of Ng, the company said it plans to invest $300 million to expand the lab, with up to 200 employees in larger quarters at the Moffett Towers office complex in Sunnyvale.
Internet companies are racing to develop new services that act more like personal assistants -- answering complex questions and anticipating users' needs or interests -- because they have run out of ways to improve on the traditional method of typing keywords into a search box, said analyst Whit Andrews at the Gartner research firm. "Search vendors want to be your robotic guardian angel," he added.
Google has used artificial intelligence and deep learning to build algorithms that can identify unlabeled photos, recognize voice commands and understand conversational speech, among other things. Facebook has said it hopes to use artificial intelligence for similar purposes. Baidu said it's using the technology for image searches, natural language processing and "advertising matching."
Microsoft and IBM also have artificial intelligence programs, while a host of smaller startups are working on mobile apps and services that use similar technology. At the TiE technology conference in Santa Clara on Friday, IBM announced partnerships with several startups that are building apps using the cognitive computing system it calls Watson.
Ng is on leave from Stanford and is stepping away from daily duties at Coursera, where he will continue as chairman, a spokesman said.
Contact Brandon Bailey at 408-920-5022; follow him at Twitter.com/BrandonBailey


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|Gingerbread House Contest
Event Type: Family Program
Age Group(s): all ages, children with an adult
Date: 12/17/2013
Start Time: All Day
The holidays are a time to do things that celebrate and create traditions. We all have cherished memories of creating something beautiful to mark this special time of year. We think decorating a gingerbread house is a perfect way to craft new memories, and we're hoping you'll join us in celebrating the sweet traditions and beauty of the holiday season by entering our gingerbread house decorating contest!Library: Urbana Regional Library
To enter, pick up a rules/entry form with recipes at the Urbana Regional Library Children's Desk. The gingerbread houses will be judged by friendly library staff.
All entries must be delivered to the library between December 1st - December 20th.
Winners will be announced Saturday, December 21st.
Entries must be picked up no later than January 5th. Library staff reserve the right to dispose of any entries that are not claimed.


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What is she holding in her left hand?
What is she holding in her left hand?
Found out it is from a youtube video as well and it has a different angle.
Aww ye, ged it gurl
What happened in the first one....?
Looks to me like it was done for a film.
Well yeah I would assume it was achieved through sudden pressure loss, or allowing it to implode from a sustained low pressure.
It certainly does suck.
I meant as in that's how they achieved the effect. I am not saying it's a real tank.


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Boys & Girls Club a finalist in national contest
Published: Monday, March 11, 2013 at 2:41 p.m.
Last Modified: Monday, March 11, 2013 at 2:41 p.m.
The Boys & Girls Club of Henderson County is a finalist in the Coca-Cola Pay It Forward Essay Contest, and are just clicks away from a $10,000 grand prize.
Residents can vote for the club until March 20.
To vote, go to www.familydollar.com/pages/coke-sweeps.aspx and log in.
The club's essay is the second one down in the Gallery. Supporters can come back and vote once daily.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
Shelton State women fall in NJCAA tournament
Published: Friday, March 22, 2013 at 3:30 a.m.
Last Modified: Friday, March 22, 2013 at 12:09 a.m.
SALINA, Kan. | Shelton State's dream season came to an end Thursday in the NJCAA Division I Women's Basketball Tournament.
Gulf Coast from Florida made 29 of 35 free throws and defeated the Lady Bucs 72-61 in the quarterfinal round. Fifth-seeded Shelton State, which won the Alabama Community College Conference title to qualify for the national tournament, finished the season with a 33-1 record.
Gulf Coast (29-4), the No. 4 seed plays No. 1 Trinity Valley (34-1) from Texas at 6 tonight in the semifinal round.
Brianna Lancaster, a sophomore center, led Shelton State with 10 points and six rebounds. Sophomore guard Dominique Henley had nine points.
Sophomore guards Porsha Blue and Sharin Rivers had eight points each. Quenisha Lockett, a sophomore center, had six points and five rebounds.
Shelton State shot 48 percent from the field, making 20 of 42 attempts. The Lady Bucs made just 3 of 17 3-point attempts and 12 of 19 free throws. Shelton State was called for 31 fouls and committed 25 turnovers.
Necole Sterling scored 16 points and grabbed seven rebounds for Gulf Coast. MarLisa Braxton, who went 8-for-8 from the foul line, scored 14 points and had seven rebounds and four steals. The Lady Commordores came up with 14 steals.
Roshinha Rosario had 14 points and four rebounds. Tamara Taylor had 14 points and six rebounds. Jessica Morton, who went 5-for-5 from the foul line, had 13 points and a team-high nine rebounds. She also had three steals.
Gulf Coast, which led 33-32 at halftime, shot 36 percent from the field (17-for-47) and made 3 of 15 3-point tries.
Gulf Coast finished with a 47-45 rebounding edge.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Beaver Cleaver's dad may have been delighted by a new tie or a crayoned promise of carwashes to come, but modern fathers are a more eclectic lot. They're lager lovers, culinary experimenters and wine devotees -- and they deserve a creative approach to Father's Day.
So we've got three ideas for the wonderful men in your life, all inspired by those Father's Day coupons of yore.
A biergarten bash
The craft beer movement is exploding in the Bay Area with new breweries and beer gardens popping up practically every week. We're not suggesting your preschooler take Dad to a bar, but Bavarian-inspired beer gardens are family-friendly places. You can sit outdoors, raise a pint -- or a glass of pop -- and enjoy bratwurst, pretzels and other noshes.
So write up a coupon for a beer garden date -- or better yet, download one of our clever versions -- and tuck it into a copy of something suitably brew-inspired, such as Napa Valley food writer Janet Fletcher's "Cheese & Beer" pairing guide (Andrews McMeel, $24.99, 106 pages). Or pair it with a batch of soft pretzels and sweet Bavarian mustard from Andrea Slonecker's beer-tastic "Pretzel Making at Home" (Chronicle, $16.95, 128 pages).
As for the destination, the much-anticipated Brotzeit Lokal -- the beer garden that Chop Bar's Lev Delany is launching on the Oakland waterfront -- opens June 13 with German brews, a Linden Street house beer, Bavarian-influenced snacks and a kids menu, too. Details: 1000 Embarcadero, Oakland; brotzeitbiergarten.com.
In the South Bay, try Mountain View's new Steins Beer Garden, which offers chops, braised lamb, fried chicken sandwiches and, of course, craft beer -- and on Father's Day, dad's first beer is free with entree purchase. The beer scene is great for the over-20 crowd, but chef Colby Reade offers a kids menu for tots, too. Details: 95 Villa St.; www.steinsbeergarden.com.
Pinot papas
If dad prefers pinot to brewskis, you'll find plenty of wine-tasting and picnicking options in the Santa Cruz Mountains, Saratoga area and Livermore Valley. But if you're looking for a special vino venture for a serious oenophile -- an outing for a dad with 20-somethings, not little ones -- try a reserve tasting at Steven Kent in Livermore. The latter includes elegant pairings of small-lot wines with artisanal cheeses and bites ($20). Summer weekends feature live music and wine tastings on the patio as well. Details: 5443 Tesla Road, www.stevenkent.com.
Book a wine cave tour ($20) at Wente or, if you're looking for something to celebrate on the day of, Wente's renowned restaurant is doing a three-course Father's Day brunch that includes chocolate and peanut butter ice cream sundaes topped with bacon-peanut brittle. Details: 5050 Arroyo Road, Livermore, www.wentevineyards.com.
Or check our Santa Cruz Mountains and Livermore Valley wine and picnic suggestions at www.mercurynews.com/south-bay-wine and www.mercurynews.com/livermore-wine, which include kid-friendly wineries with bocce and other playful options.
Food trucks and pitchers
What better place to tuck a coupon for a day of baseball and street food than a copy of James Cunningham's new "Eat St." (Pintail, $20, 290 pages)? The cookbook, a companion to Cunningham's popular street food series on the Cooking Channel, includes recipes from seven Bay Area trucks, including Roli Roti, Sam's ChowderMobile and Babaloo.
Giants fans can opt for a little street food snacking on Sundays, when Off the Grid rolls into China Basin from 11 a.m. to 3 p.m. A rotating array of gourmet food trucks -- Curry Up Now, Phat Thai, Rib Whip and others -- parks at Third and Berry streets, next to AT&T Park.
Too devoted to the A's to cheer for the orange? The Oakland A's 17th annual Beer Festival runs from 2:15 to 4:15 p.m. on June 15 at the Coliseum's Eastside Club. Plus there's an Off the Grid: Picnic at the Presidio every weekend and OTGs in Hayward, Belmont, Alameda, Berkeley and other cities, too. Find details at http://oakland.athletics.mlb.com and Facebook.com/OffTheGridSF.


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AKA Univers 39. Significantly different than the other styles of Univers, this very narrow — and very square — variation of the family deserves its own typeface entry.
Contribute to the Collection
Fonts in Use is a collaborative project. Create an account and submit your own work or other examples of typography.
Jazz en Claypole: Festival Internacional de Jazz2013
- Max Rompo
- Pontenpie
Contributed by Stephen Coles
Staff Pick
Rijksakademie van Beeldende Kunsten Amsterdam Verslag 20112012
- Roosje Klap
Contributed by Florian Hardwig
Entwicklungen at Museum für Naturkunde Berlin2013
- Sonja Kreft
Contributed by Florian Hardwig
Staff Pick
Donald Trump ad: John Kasich All Talk No Action Politician2016
- Donald J. Trump For President
Contributed by Stephen Coles
I Never Loved A Man The Way I Love You1999
- Karen Horton
Contributed by Stephen Coles
Staff Pick
Ray Charles Commemorative Stamp2013
- Ethel Kessler
- Neal Ashby
- Yves Carrère
Contributed by Chris Purcell


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- Tea Pouches
- Loose Tea
- Iced Tea
- Teaware
- Gifts
- Sale
- Why Mighty Leaf?
Marrakesh Mint
Gunpowder green tea from China and refreshing Moroccan mint blend together to create our Marrakesh Mint green tea. Enjoy this classic green tea blend and find yourself whisked away to cascading waterfalls deep in the mountains of Morocco. Host friends and family with this lively green tea brightened with mint cultivated on a mountain in Tiznit.
Loose tea in 4 oz. bag
Green tea, mint
Tightly rolled pellets of green tea, dried mint
Cool, clean mint
Light green liquor
Round and refreshing body with lively mint
Preparing the perfect cup of tea is a process to be savored. Watch how the traditional elements harmoniously come together to make the perfect cup and enjoy the liberation of pure tea goodness.
This is what we call the Mighty Leaf signature multi-sensory ("sensory melange") tea experience. Come share with us and learn how to get infused.
Hot and iced tea brewing instructions are listed below.
Hot Tea ::
The quality of tea is affected by the quality of water used to prepare it. Using filtered or bottled water is best. If possible, avoid brewing tea with tap, distilled or mineral water. Never over-boil water, as it results in flat-tasting tea.
1) Heat filtered or bottled water to 170F-180F or in the alternative heat to a boil and let sit for 1-2 minutes. 2) While the water is heating pour hot water into your teapot and cups, let sit and then drain completely. A warm teapot will maintain the requisite temperature for superior tasting tea.
Whole Leaf Tea
Prepare Mighty Leaf teas using a teapot, paper tea sachet, infuser or traditional brewing methods. Use one level tablespoon of loose green tea per 12 ounces or cup of water.
Infusion Time
Pour boiling water over tea leaves. Keep teapot covered to retain heat. Time steeping carefully and infuse for 2 - 3 minutes.
Savor the Leaf
Sip your cup and rediscover the pleasure of the way tea was naturally meant to be. This is the magic of Mighty Leaf.
Iced Tea ::
A stronger brew is required for iced tea than for hot tea because of ice's dilution action. Prepare a tea concetrate as follows:
Single Serving
For a single serving, prepare as for hot tea, use one level tablespoon of loose tea per 6 ounces of water and after brewing pour over ice in a 12 oz glass.
Large Serving
1. For a larger serving, prepare a iced tea concentrate by bringing one quart of cold water to a rolling boil in a tea kettle.
2. Remove from heat and add 8-10 teaspoons per quart of brewed tea.
3. Steep 2 - 3 minutes or to desired strength.
4. To serve immediately, pour over ice in a tall glass, or add another quart of cold water to the concentrate and chill in refrigerator.
China, Morocco
Health Benefits
Green tea
Both black and green tea originate from the same plant, the Camellia sinensis. However, the final product differs in style, taste and caffeine content due to differences in processing. Green teas are not fermented or fully oxidized like black teas, but instead steamed or pan fired.
Like black teas though, green tea contains an abundant source of natural plant-derived antioxidant compounds called polyphenols. Included within the broad antioxidant polyphenol class are flavonoids and catechins. A kind of flavonoid, catechins are found in tea leaves and may provide protective antioxidant action against harmful free radicals. Research shows that these free radicals cause heart disease, some kinds of cancer and increase the risk of strokes.
Drinking green tea with its high antioxidant levels help protect the body by combating dangerous free radical activity. Further health benefits of green tea may include lowering cholesterol, strengthening the immune system, promoting healthy blood vessel functionality and even protecting teeth and bones. In addition, green tea provides a source of nutrients including magnesium, Manganese, potassium, calcium, and the vitamins C and K all in trace amounts.
Mint promotes healthy digestion and aids in soothing indigestion. Get a dose of aromatherapy too, as the scent promotes calm and quiet.
Share this classic tea with friends and family any time of day. Start your own mint green tea ritual, like in Morocco where tea is drunk everywhere as a sign of hospitality and sharing. Prepare in a traditional metal teapot and pour into beautiful Moroccan glass cups adorned with color, elegant designs. Add lumps of sugar and serve with small cakes and pastries.
Pairs well with savory and spicy foods.
Subscribe and save 5% with Regular Tea Rituals, our Auto-Delivery Program. Details
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There was a disastrous fire Wednesday on Silver Fox Way just outside the North Augusta city limits in the Graniteville fire district. And the windy day may have helped spread the flames.
The area is near Old Sudlow Lake Road. Firefighters say it all started in the grass at a neighbor's house and then spread next door. The family is still going through what's left of their belongings.
The 911 call came in at 1:48 pm. And 5549 Silver Fox was completely up in flames minutes later. Neighbor Jason Brooks smelled smoke through his open window.
"I thought it was trash burning, then we had a knock on the door and they said it was on fire."
The man at the door was the one who first noticed the tiny flame when it started in the yard. He called 911.
"It went up so quick and in less than five minutes it was in the house," says Brooks.
The family of four is okay. The father was home when it all started and the wife and two kids drove up shortly after.
"It's just very unfortunate the fire started in this neighborhood and the family lost everything. We thank god no one was hurt," said fire chief Phil Napier.
Brandee Anderson first saw her neighbor's house after the damage had been done.
"It's a tragic thing and I hate that I had to go through it but being the type of neighbors we are, we'll come together."
That's compassion that Jason Brooks shares.
"Hopefully everyone can get together and help the family out. We'll do what we can."
The flames eventually died out. But the investigation into what caused the spark continued.
An investigator told News 12 that the spark from a "carelessly discarded smoking item."
The combination of dry grass and pine straw plus high winds caused the fire to spread so quickly.
The family who lost their home went through another fire ten years ago.


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Leonard Evers (*1985)
Musical theatre by Leonard Evers for audiences aged 5 and older
Libretto by Flora Verbrugge, after the Brothers Grimm; German translation by Barbara Burri
First performed on 30th September, 2012, at the Theatre Sonnevanck, Enschede
Premiered at the Tischlerei on 5th December, 2014
|Stage Director
|Annechien Koerselman
|Set design; Costume design
|Dieuweke van Reij
|Anne Oppermann
|Christina Sidak
|Daniel Eichholz
|Lukas Böhm
Jacob lives with his parents on the coast. 'Lives' is hardly the word for it; they're so poor they don't have a house, not even shoes. Yet they're happy. One day Jacob goes fishing with his father and catches a huge fish. The fish promises to grant Jacob anything he wishes as long as Jacob lets him go. After pondering on what he could wish for, Jacob hits on shoes. And lo and behold, he gets a lovely pair of shoes! Trouble is, his parents would quite like some shoes, too. And a house …or a villa. Or maybe a castle. Every day they send Jacob back to the fish and the fish makes all their wishes come true. But Jacob feels bad because the fish is meanwhile growing thinner and thinner. And he and his parents are not getting any happier…
GOLD uses music and humour to explore the thin line between justifiable wishes and unbridled greed. Yet what is happiness exactly? In any case, the work ends with Jacob as happy as can be. GOLD is sung, narrated and acted out by a female singer and a male drummer.
The piece is directed by Annechien Koerselman, who is known for her original and music-oriented productions for young audiences. Following her success with the children's opera CAN YOU WHISTLE, JOHANNA in the 2013-2014 season, the winner of the 2012 "Junge Ohren" Award returns to the Tischlerei in the Deutsche Oper Berlin with her production of GOLD.
A coproduction with the Theater Sonnevanck, Enschede


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How Do You Accessorize Your Yoga Poses?
Peep into any of the thousands of yoga classes across the globe and you will find that students are donning more than just yoga outfits. In addition to the latest leggings and tank tops by Zobha, Gaiam and Alo, you'll also find students of every age, both male and female, sporting a different kind of accessory. These, however, are not made from lycra, mala beads or precious metals, but rather from an overzealous nervous system.
Glance around the room after the teacher calls out "Twisted Half Moon" (Pavritta Ardha Chandrasana) and you'll see students with arms akimbo, clenched toes, fingers curled and faces contorted beyond recognition. These students are "accessorizing" their poses with parts of their body that don't actually need to be involved.


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The Sportful Bodyfit Pro Cap features breathable cotton construction and is perfect for summer cycling. One size fits all, the cap is complete with multi stripe detail down the middle and Sportful branding. - A.D.
Key Features:
Please remember to add postal time (2-3 working days) to obtain a complete estimate of delivery to your door.
You will receive an email to confirm when your item has been sent.
You can also check the status of your order and individual items by accessing your account details and following the prompts.
Please allow 10 working days from dispatch of your order before notifying us of any late deliveries.
It may be advisable to check with your neighbors to see if your delivery has been left with them, check any places it could be left such as: garage, porch, or behind garbage cans if it was too big to fit through your mailbox. Contact your local post office to see if the item has been returned to the depot as undelivered and awaiting collection.
Please see our returns policy.
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PHIL LACIO AKA P DAWG wrote: this will be purchased in due time
I wouldn't have minded secret bonus tracks of
the joan of arcadia remix ( that version is haunting)
an house of bees
SFR announcement wrote: Download the first single. It's for free. Can't make it any easier for ya, Tommi.
tommi teardrop wrote: Are the beats hip hoppy or blip/glitch hoppy?


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4 win cash for 2-D, 3-D works
Published: Sunday, March 10, 2013 at 3:15 a.m.
Last Modified: Friday, March 8, 2013 at 3:49 p.m.
The Artists' Guild of Spartanburg recently awarded cash prizes of $250 to four members whose work was chosen in February's all-member show.
The recipients were:
-- 2D Painting: Isabel Forbes' "Sunday Morning Breakfast"
-- 2D Drawing and Mixed Media: Carolyn Alexander's "How Much is That Kitty in the Window?"
-- 2D Photography and Digital Photography: Patty Wright's "Pink Surprise"
-- 3D Sculpture, Pottery, Jewelry, and Stained Glass: Doris Wright's "Salts and Squares"
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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|Eldoret, Kenya
|High School:
2012 CROSS COUNTRY (SOPHOMORE): Had his best finish of the season in the Islanders Splash (9/28) coming in 10th … recorded a season-best time in the 8k at the Southland Conference Championships with a time of 25:38.1 (10/26).
PRIOR TO TEXAS A&M - CORPUS CHRISTI: At UTEP ran a personal-best 31:58.00 in the 10k at the Mountain Region Cross Country Championships to place in the top 50 ... placed 14th at the Conference USA Championships, with a personal record of 24.36.60 in the 8k ... recorded personal-best records in the 1500m and 5000m at the Conference USA Championships in May of 2011 ... placed sixth in the 1500m with a time of 3:48.75 and crossed the line in 11th place in the 5000m with a time of 14.49.83.
HIGH SCHOOL: Attended Kabianga Boys High School in Kericho, Kenya.
PERSONAL: Born Abel Kiplagat Koskey on Jan. 9, 1988 in Kitale, Kenya ... parents are Joseph and Selina Koskey ... has four siblings ... major is nursing.


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A visit from the healing muse: 'Dread'
Deirdre Neilen, PhD shares a selection from Upstate's literary journal, "The Healing Muse" every Sunday on HealthLink on Air. Neilen is the editor of the annual publication featuring fiction, poetry, essays and visual art focused on themes of medicine, illness, disability and healing. Today's selection is 'Dread', by Ronald Ruskin, and can be found in the The Healing Muse, Volume 13.
Order your copy of "The Healing Muse" today! Read The Healing Muse Cafe Blog.
Podcast: Play in new window | Download


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Beta Testing the Sun Grid Engine Hadoop Integration
By templedf on Nov 30, 2009
In case you haven't heard yet, the upcoming release of Sun Grid Engine will include an integration with Apache Hadoop that will allow Map/Reduce jobs to be submitted to a Sun Grid Engine cluster while minding HDFS data locality. The 6.2u5 release will be out by the end of the year, but it's currently in the beta testing phase. And that's where you come in.
I'm looking for some volunteers to test the integration. To that end, this blog post will provide instructions for how to get the beta code checked out and built. The Hadoop integration is actually only loosely dependent on the Sun Grid Engine software itself. While it's planned to be part of u5, the integration should be usable with a cluster as old to 6.2u2, although I would really recommend at least 6.2u4.
In a nutshell, the integration consists of two components. The first is the hadoop parallel environment that allows Map/Reduce jobs to be started as parallel jobs in a Sun Grid Engine cluster. The second is the integration with HDFS, called Herd, that makes the Sun Grid Engine scheduler aware of the locations of the HDFS data blocks. Herd has two parts. One part is a load sensor that runs on every execution machine and reports the HDFS blocks on that machine. The other part is a JSV that translates HDFS data paths included in the job submission into a list of HDFS blocks needed by the job.
How to check out the source code
- Make sure you have a functional CVS client.
- cvs -d :pserver:email@example.com:/cvs login
- cvs -d :pserver:email@example.com:/cvs checkout gridengine/source
Technically, the above will only check out the source directory, but for the Hadoop integration, that's all you need. The Hadoop integration lives in three places. First, the scripts live in source/dist/hadoop. Second, the Herd code lives at source/libs/herd. Third, the JSV Java language binding upon which the Herd code depends lives at source/libs/jjsv.
How to build the source code
- Make sure you're using at least Ant 1.6.3 and the Java Standard Edition 6 platform.
- Copy the source/build.properties file to build_private.properties.
- Edit the build_private.properties file to include the corrects paths for the Java Standard Edition 6 platform and junit 3.8.
- Change to the gridengine/source directory.
- ant jjsv
- ant herd
After the above steps, you will find herd.jar at source/CLASSES/herd/herd.jar and JSV.jar at source/CLASSES/jjsv/JSV.jar.
How to install the integration
- Copy herd.jar and JSV.jar to the $SGE_ROOT/lib directory.
- Copy the source/dist/hadoop directory to somewhere accessible by all the execution nodes.
How to configure the integration
- Get HDFS up and running on your cluster. The most useful configuration will be to have every execution host be a data node, and to only have execution hosts as data nodes. Also, because of the way Hadoop does authentication and authorization, you'll need to make sure that either HDFS has security disabled or that root and the SGE admin user are in the HDFS super user group.
- Copy your Hadoop configuration directory to <hadoop>/conf, where <hadoop> is the directory that you copied in step 2 of How to install the integration.
- Delete the <hadoop>/conf/mapred.xml, <hadoop>/conf/masters, and <hadoop>/conf/slaves files.
- Edit the <hadoop>/env.sh file to contain the paths to the Java platform, the Hadoop install directory, and the Hadoop configuration directory you just created (<hadoop>/conf).
- Change into the <hadoop> directory.
- ./setup.pl -i
- Add the hadoop parallel environment to one or more of your queues
The setup.pl script will install the hadoop parallel environment and the complexes needed by Herd. It will also start the Herd load sensor on all the execution hosts. At this point, you should be ready to go. Wait for a couple of minutes to give all of the execution hosts a chance to start running the load sensor and reporting values. You can run qhost -F hdfs_primary_rack to check that the load sensor is functioning correctly. Every execution host should report an hdfs_primary_rack value. If one or more machines have not reported a value within about five minutes, see the troubleshooting section below.
Using the integration
To submit a job that uses the hadoop parallel environment, use -pe hadoop <n>, where <n> is the number of nodes. The hadoop parallel environment uses an allocation rule that guarantees that no more than one task tracker per job will run on a single host. To tell the scheduler what data the job needs, request the hfds_input resource with a value of the HDFS path to the job's data. The data path must be an absolute path.
Here's an example. Say I want to use the grep example to find occurrences of the word 'Sun' in a series of documents. First, I'd copy those document into HDFS to /user/dant/sungrep (e.g. bin/hadoop fs -copyFromLocal ~/Documents/\* /user/dant/sungrep). I would then submit the job with echo `pwd`/bin/hadoop --config \\$TMPDIR/conf jar `pwd`/hadoop-0.20.1-examples.jar grep sungrep output Sun | qsub -pe hadoop 16 -l hdfs_input=/user/dant/sungrep -jsv <hadoop>/jsv.sh.
Let's look at that in a little more detail. First, we're echoing the Hadoop command and piping it to qsub. Why? Well, when the integration runs, it creates a conf directory in the job's temp directory that is properly set up for the assigned hosts. Until the job runs, though, we don't know where the temp directory is. We get it's path from the $TMPDIR variable once the job starts. We therefore need to wrap the Hadoop command in a script. We could either write a script that contains the command, or we could let qsub write one for us by piping the command to qsub's stdin. Note that we used --config \\$TMPDIR/conf in the command. The backslash is important because it prevents the shell on the submission host from interpreting the $TMPDIR variable.
Next, the qsub command uses -pe hadoop 16 to request 16 nodes. When this job is run, a job tracker will be started on the "master" host, and a task tracker will be started on each of the 16 assigned nodes. The master host is the host where the parallel job's master task is started. After the job tracker and task trackers are running, the grep job itself will be started, launched from the master host. The hadoop PE is a tight integration with an allocation rule of "1". In order to run a Hadoop job on top of SGE, you must use the PE, even if it's only a single-node job.
The qsub command also uses -l hdfs_input=/user/dant/sungrep -jsv <hadoop>/jsv.sh. The -l resource request tells SGE what data will be used by the job. It must be specified as an absolute path. The -jsv switch actually translates the resource request for hdfs_input into requests for specific racks and blocks. Without the -jsv switch, the job would never run because no node offers the hdfs_input resource. (No node offers it because it doesn't really exist. It's just a placeholder for the JSV to replace with rack and block requests. In programming terms, it's a reference injection point.) The resource request and JSV can be left out of the qsub command. If they're left out, the scheduler will not take the HDFS data locality into consideration when scheduling the job.
You can also use the Hadoop integration to set up the job tracker and task trackers and then submit jobs to them directly. Instead of echoing the Hadoop command to qsub, echo sleep 300000 instead. That will cause the job tracker and task trackers to be set up, but instead of running a job, it will just sleep for a long time. You can then run qstat -j <jobid> | grep context to show the job's context. One of the context variables will be the URL for the job tracker. Using that URL, you can set up a Hadoop configuration to talk to the job tracker so that you can submit jobs to it from the command line.
It is also highly recommended that the use of the Hadoop integration be coupled with exclusive host access. The Hadoop task trackers all assume that they have exclusive access to their nodes. If you don't use exclusive host access with the Hadoop integration, you'll end up oversubscribing the nodes.
Hopefully everything will work perfectly the first time. If for some reason it doesn't, here are some tips to help diagnose the problem:
- The execds aren't reporting any hdfs resources, i.e. qhost -F | grep hdfs shows nothing.
- Sometimes it takes several minutes for the nodes to start reporting the hdfs resources. If after several minutes there's still nothing, pick an execution host and check if the load sensor is running: jps -l. Look for com.sun.grid.herd.HerdJsv. Note that it might be running as root or as the SGE admin user. Also note that jps may only show you your own processes. If the load sensor isn't running, look for log files in /tmp. They will be called sge_hadoop_loadsensor.out and sge_hadoop_<n>.log. The .out file is the output from starting the load sensor. The .log files are the logging output from the load sensor. One will be the log file from the load sensor framework, and the other will be the log file from the Herd load sensor. (You can control the logging verbosity from the logging.properties file in the <hadoop> directory.) The most common problem is that the load sensor is started as the user root on most platforms (for a reason I don't yet understand), but that HDFS usually is not. With HDFS, the user who started it is the super user, and only the super user can query the kind of information that the load sensor needs. As stated in the configuration section, you must either disable HDFS security or set a super user group that contains root (and probably the SGE admin user). The next most common problems are that the path to Hadoop or the Java platform is not correct in env.sh or that the conf directory contains bad configuration information. You can test the load sensor manually by changing into the <hadoop> directory and running loadsensor.sh. If it works, it will "hang". Press enter, and it should spit out the hdfs resource values for that host. Type QUIT and press enter to exit the load sensor.
- The job tracker and/or task trackers aren't starting.
- The first place to look is the PE output and error files. The output from starting the job tracker should be found there. The next place to look is the log files. The log files are written where the Hadoop configuration says to put them. Make sure that wherever that is, all the users have access to it from all the nodes. Inability to write the log file is a common reason why the job tracker and/or task trackers won't start. In addition to the usual Hadoop log files, the integration also write a hadoop-<adminuser>-sge-<hostname>.log file. That file contains the output from starting the task trackers from the master host. Another common reason for the job tracker and/or task trackers not to start is that the path to the Java platform isn't correctly configured in the hadoop-env.sh file.


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Aloha Lodge
Aloha Lodge, Bed & Surf Cape Town! Meet Gerhard, the german Rasta in his relaxed and cool place! He makes you feel home and he likes to share his stories about Africa, the continent he is so much in love with!
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hostel Facilities & Policies
- Adaptors
- Airport Transfers
- Bar
- Board Games
- Book Exchange
- Cable TV
- Common Room
- Free Internet Access
- Free Parking
- Free WiFi
- Games Room
- Hot Showers
- Internet Access
- Self-Catering Facilities
- Laundry Facilities
- Linen Included
- Security Lockers
- Outdoor Swimming Pool
- Outdoor Terrace
- Parking
- Pool Table
- Reading Light
- Steam Room
- Swimming Pool
- Towels For Hire
- Towels Included
- Washing Machine
Cancellation PolicyThis property has a 1 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
DirectionsShow MapHide Map
From N2 towards city until turn-off (N2-M5) North Milnerton.
Follow the M5 into Milnerton and drive on Koeberg Road for approx. 5km. After the intersection with Boundary Road turn into the first street on your left (Algoa Road). Aloha Lodge is the 3rd house on your right with a big black spiderweb gate.
Located Near
Aloha Lodge is located north of Cape Town in Milnerton, a peaceful and secure suburb at the Atlantic seaboard. From here it only takes 15 minutes by car into the city centre. You can get onto the fast MyCiti bus system at a bus stop in close vicinity.
The wine region around Stellenbosch and Paarl is only 45 minutes away via the N1 highway.
The Milnerton Lagoon is just a short walk away. Enjoy your long walk at the beach.
Here you can see where we are: http://goo.gl/maps/pwiff