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KC Huang (Stanford University)
Special Seminar
KC Huang
KC Huang was an undergraduate Physics and Mathematics major in Page House at Caltech, and spent a year as a Churchill Scholar at Cambridge University working with Dr. Guna Rajagopal on Quantum Monte Carlo simulations of water cluster formation. He received his PhD from MIT working with Prof. John Joannopoulos on electromagnetic flux localization in polaritonic photonic crystals and the control of melting at semiconductor surfaces using nanoscale coatings. During a short summer internship at NEC Research Labs, he became interested in self-organization in biological systems, and moved on to a postdoc with Prof. Ned Wingreen in the Department of Molecular Biology at Princeton working on the relationships among cell shape detection, determination, and maintenance in bacteria. His lab is currently situated in the departments of Bioengineering and Microbiology&Immunology at Stanford, and his current interests include cell division, membrane organization, cell wall biogenesis, and collective motility of bacterial communities. His lab is a force to be reckoned with in pickup basketball.
Structural Dynamics Reveal New Mechanisms of Feedback Between Cell Geometry and Intracellular Organization
The assembly of protein filaments drives many cellular processes, from nucleoid segregation, growth, and division in single cells to muscle contraction in animals. In eukaryotes, shape, motility, and cytokinesis are regulated through cycles of polymerization and depolymerization of actin and microtubule cytoskeletal networks. In bacteria, the actin homolog MreB and the tubulin homolog FtsZ form filaments that coordinate the cell-wall synthesis and division machineries, respectively. A fundamental challenge in cell biology is to link the structural properties of these filaments to cellular behaviors and morphogenesis. We have used all-atom molecular dynamics simulations to reveal the nucleotide-dependent polymer mechanics of these cytoskeletal filaments. For FtsZ, our simulations predict that small changes at the monomer-monomer interface result in a large hinge-opening leading to filament bending upon GTP hydrolysis, which was confirmed solving the structure of an FtsZ-GDP filament by X-ray crystallography. Next, I will demonstrate that similarly subtle modifications to the interprotofilament interface in microtubules due to acetylation are responsible for perturbing the quinary structure of the microtubules enervating touch receptor neurons in C. elegans, leading to a defect in mechanosensation. We observe that MreB exhibits actin-like polymerization-dependent structural changes, wherein polymerization induces flattening of MreB subunits, and hydrolyzed polymers favored a straighter conformation. Taken together, our results provide molecular-scale insight into the diversity of structural states and the relationships among polymerization, hydrolysis, and filament properties within the actin and tubulin families. I will close by demonstrating a novel curvature-sensing strategy of the protein SpoVM, which initializes the formation of the spore coat in Bacillus subtilis. Taken together, our results highlight the expanding utility of molecular dynamics to link the atomic scales of protein function and the cellular scales of behavior.
Free and open to the university community and the public


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Knitter's Review
November 21, 2013
Earlier this month, some 120 lovely knitters and I gathered on the shores of Lake Canandaigua for the 12th-annual Knitter's Review Retreat.
I came away with a greater understanding of how knitters work: what we need, and what happens when we get it.
Indiegogo: Let's Bring a Mill to Mendocino
FedEx Goes Crazy for Cozies
Makers Monday
In the Forums: Ladders?
Need help logging into the Forums?
As ever, I thank you for letting me be a part of your knitting life.
We'll talk again on December 5!
P.S. Do you have friends who would enjoy Knitter's Review? If so, don't hesitate to forward this email to them.
Knitter's Review Poll
Are you over fingerless mitts yet?
Participate in our Knitter's Review Poll and you'll see an instant tally of all the votes.
On the Cover
Give knitters a fire and they will gather
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subset: commoncrawl


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Michelle Badash, MS
The following lifestyle changes may help you manage fibromyalgia.
Exercise is perhaps the most effective way to improve fibromyalgia symptoms. Benefits include:
Your exercise program should begin with mild activity and gradually increase over time. Try to incorporate different types of exercise, like:
Exercising in a heated pool may offer benefits. In one small study, researchers found that people with fibromyalgia who participated in aquatic training in warm water (strength, aerobic, and relaxation exercises) reported an improvement in symptoms.
Some people with fibromyalgia have found that certain techniques that help you relax and reduce stress may be helpful in managing chronic pain. Examples of successful techniques include:
Fibromyalgia. American College of Rheumatology website. Available at:
http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Fibromyalgia. Updated February 2013. Accessed August 8, 2013.
Fibromyalgia. EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed. Updated July 15, 2013. Accessed August 8, 2013.
Fibromyalgia. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at:
http://www.niams.nih.gov/Health_Info/Fibromyalgia/default.asp. Updated August 2012. Accessed August 8, 2013.
Treatment. Fibromyalgia Network website. Available at:
http://www.fmnetnews.com/fibro-basics/treatment. Accessed August 8, 2013.
Treatment. National Fibromyalgia Association website. Available at:
http://www.fmaware.org/about-fibromyalgia/treatment. Accessed August 8, 2013.
Last reviewed September 2015 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Publishing. All rights reserved.


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This is the Warriors draft that isn't about drafting anybody, which really is not a bad thing for this newly risen franchise.
Literally, the Warriors have no choice: Thanks to multiple past trades, they currently have no draft picks for Thursday's two-round proceedings.
And generally, the Warriors roster is deep enough and their long-term options are interesting enough that team executives don't have any desperation for a new rookie influx.
They don't need a new P.R. gimmick; they don't need a new face to sell tickets. They don't need the draft for momentum this year.
Good thing, too, by the way, because this draft is one of the weakest in years.
Let me add here, however, that there's a decent shot that the Warriors will flash some of Joe Lacob and Peter Guber's cash and buy a second-round pick if they see somebody intriguing falling into the mid-40s.
But that would strictly be a flier, maybe for more depth at point guard, and that's not what this period is about for them.
This is about getting a head start on planning for the July movement period without having to wade through much of the draft analysis.
Already, the post-draft machinations have begun: On Wednesday, as expected, veteran forward Carl Landry declined his option for next season and will be an unrestricted free agent on July 1.
That removes his $4 million salary from the books and also makes the Warriors even more interested in shopping for discount veteran help in the frontcourt.
And I also believe it makes it unlikely that Landry will be a Warrior next season, despite all his production during the playoff run.
First, it's clear that the Warriors' top priority is to either re-sign backup point guard Jarrett Jack or to find a suitable replacement if Jack's price tag gets too high.
The Warriors are over the salary-cap line and have only a little bit of financial wiggle room, so Jack's situation alone could eat up most of their available money.
The Warriors already have about $70 million in commitments to 11 players next season, and that's bumping near the luxury-tax threshold.
If you pencil in about $5 million per year for Jack, that brings this season's payroll to $75 million.
And that would just about do it for the Warriors -- maybe they could squeeze in a play-making wing in free agency, maybe not.
Second, the Warriors front office has a lot of faith in Draymond Green, who theoretically could slide right into Landry's role as David Lee's backup at power forward.
Plus, Harrison Barnes played some power forward in the playoffs in a small/quick lineup, when Lee was hurt, and Brandon Rush, coming back from a season-long injury, has played both forward spots at times.
That's a reminder: The Warriors essentially rebuilt the middle of their roster with their last two drafts, and they hope those players will claim larger and larger roles.
The Warriors landed Barnes, Green and Festus Ezeli last year. And they plucked Klay Thompson in 2011.
If Andrew Bogut, Lee and Stephen Curry all remain mostly healthy next season, the growth of this team is going to come from the young players already on the roster.
In the bigger picture, the Warriors have almost $40 million coming off the books after this season, and I believe they're very much looking forward to that vast flexibility next summer.
Next summer, the contracts of Richard Jefferson, Andris Biedrins, Rush and Bogut all expire; of course the Warriors probably would want to re-sign Bogut, but it also gives them options.
They could search for the monster free agent, and yes, a few will be available next summer.
They could acquire a larger salary or two and easily fit it all financially. They could do a lot of things that they can't and won't do this summer.
The Warriors might not do anything at all during Thursday's draft -- no anticipation, no drama, no pressure, no extra excitement.
For once, they don't need much of that. This year, all they need is a plan, discipline and to keep building on what's already there.
Read Tim Kawakami's Talking Points blog at blogs.mercurynews.com/kawakami. Contact him at email@example.com.
NBA Draft
When: Thursday, 4 p.m.
Where: At Barclays Center, Brooklyn, N.Y.
TOP FIVE PICKS: 1. Cleveland. 2. Orlando. 3. Washington. 4. Charlotte. 5. Phoenix.
WARRIORS PICKS: None.
Cal's Allen Crabbe, above, appears likely to go in the first round. Page 2.
Carl Landry opts out of his Warriors contract, says it was a tough decision. Page 2.


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Willie Ree Higgins
Published: Wednesday, January 30, 2013 at 8:07 a.m.
Last Modified: Wednesday, January 30, 2013 at 8:07 a.m.
SPARTANBURG, SC-- Mrs. Willie Ree Higgins, 70, of 224 Pioneer Place, died on January 28, 2013, at Spartanburg Medical Center after a long illness.
A native of Laurens, SC, she was the daughter of the late Mr. Willie Gentry and Catherine Adams. Mrs. Higgins attended Cornerstone Baptist Church.
Ms. Bennett leaves to cherish fond memories: one son, Mr. Juhnny Higgins; and a host of other relatives and friends.
The family is at the home.
Funeral Home
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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NEW: For a prettier blog interface, see the Wordpress version!
|Add arbitrary file extensions : E-Mail from Chris Parsons (2005.06.07 planner help)
|Pick Gabriel's brain about working with 21-28 year olds and teaching them productivity : E-Mail from Gabriel Narciso (social)
|Reply about file format : E-Mail from Richi's server (2005.06.07 planner help)
|Make diary insert as a list : E-Mail from Edgar Gonçalves (2005.06.07 planner help)
|Check out Slashdot from 2005.06.07
|Reply about sending people tasks : E-Mail from Christopher Allan Webber (2005.06.07 feature planner)
|Reply to windsprints on LJ : E-Mail from LiveJournal Comment (social)
1. Software Freedom Day
1. Why Sept. 10? What's the significance of that date?Hehe... well, that wss the day that Open Minds (now the Opensource Technology Association of the Philippines) declared "war" on Microsoft in a press conference back in 2002.
Note that the Software Freedom Day, worldwide, strongly discourages bashing of any companies or individuals. Including Microsoft.
It's not about war. It's about freedom.
For consumers, it could be as simple as the freedom to take advantage of freely-available quality software that they might not know about. Tell your friends about Mozilla Firefox, GAIM, GIMP, and other neat programs that run on even Microsoft Windows.
For students and hobbyists, it could be the freedom to participate in world-wide projects and make a difference not only through code but also through equally valuable efforts like art, translation, and documentation.
For companies, it could be the freedom to deploy best-of-breed solutions without having to allocate budget for yearly licensing.
This is your opportunity to show people what they can do. Listen to their needs and help them find answers.
Most people don't care about being anti-Microsoft. If people think that the best arguments we can make for Free software is that it's not Microsoft and it doesn't cost a thing, then we're even further from Freedom than we thought.
その限られた性能のために私はコンピユーターに幻滅を感じている。 Its limited capability has disenchanted me with computer.
On Technorati: opensource, rant, soapbox
2. Adding an arbitrary extension to your planner files
Do you want all of your planner files to have a TXT extension so that they'll be searched by tools such as Google Desktop or Apple Spotlight?
Use the 'rename' tool to add .txt extensions to all of your files, or use the following code to rename all of your planner files from a running Planner setup:
(defun my-rename-planner-files () "Rename all my planner files to .txt if they don't have that extension yet." (interactive) (mapcar (lambda (file) (unless (string-match "\\.txt$" (cdr file)) (rename-file (cdr file) (concat (cdr file) ".txt")) (message "%s" (cdr file)))) (planner-file-alist)) (with-planner (emacs-wiki-refresh-file-alist)))
Then add this to your ~/.emacs before you load Planner:
(setq emacs-wiki-ignored-extensions-regexp "\\.txt") (defadvice emacs-wiki-find-file (around extension activate) "Open the Emacs Wiki page WIKI by name. If COMMAND is non-nil, it is the function used to visit the file. If DIRECTORY is non-nil, it is the directory in which the Wiki page will be created if it does not already exist." (unless (interactive-p) (setq wiki (cons wiki (cdr (assoc wiki (emacs-wiki-file-alist)))))) ;; At this point, `wiki' is (GIVEN-PAGE FOUND-FILE). (if (cdr wiki) (let ((buffer (funcall (or command 'find-file) (cdr wiki)))) (if (= (prefix-numeric-value current-prefix-arg) 16) (with-current-buffer buffer (set (make-variable-buffer-local 'emacs-wiki-directories) (cons (file-name-directory (cdr wiki)) emacs-wiki-directories)) (set (make-variable-buffer-local 'emacs-wiki-file-alist) nil))) buffer) (let* ((dirname (or directory (emacs-wiki-maybe t) (car emacs-wiki-directories))) (filename (expand-file-name (car wiki) dirname))) (unless (file-exists-p dirname) (make-directory dirname t)) (funcall (or command 'find-file) (concat filename ".txt")))))
新しいパソコンを買うつもりで金を溜めているんだ。 I am saving money in order to buy a new personal computer.
I'd love to hear about any questions, comments, suggestions or links that you might have. Your comments will not be posted on this website immediately, but will be e-mailed to me first. You can use this form to get in touch with me, or e-mail me at [email protected] .


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The coat as a cover and a mark of style. A story of elements, atmospheres, consistencies. It steals colours and textures from the changing autumn landscape, conveying them to the surfaces of coats made with the finest tailoring skill.
The asymmetrical precious embellishment: pure wool wrap coat with fox fur lapels. Make a statement.
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INDIANAPOLIS -- Tony Kanaan had one more lap, one anticlimactic last lap under the yellow caution flag, to end 12 years of frustration in the Indianapolis 500.
He flipped up his visor to wipe away tears as the crowd roared its approval, and then in Victory Lane gave his bride of two months a kiss and poured the celebratory winner's milk over his head.
Kanaan is Indy's hard-luck loser no more. He is its champion at last, fittingly with a dose of good luck for a change.
"I have to say, the last lap was the longest lap of my life," he said.
It was one of Indy's most popular victories.
Dario Franchitti, whose crash brought out the race-ending caution, stood grinning by his crumpled car, two thumbs up as Kanaan passed under yellow.
"When I saw who was leading, it cheered me up a little bit," said Franchitti, last year's winner. "He's a very, very deserving winner."
The fans thought so, too, screaming "TK! TK! TK!" as he and team owner Jimmy Vasser went by during the traditional victory lap. It felt magical to Kanaan, like he had given the crowd at Indianapolis Motor Speedway a gift.
"It means a lot to me because so many people, I could feel that they wanted me to win, and it's such a selfish thing to do because what are they getting from it?" Kanaan said. "I'm the one who gets the trophy. I believed that this win was more for people out there than for me.
"I wanted it all my life, but over the years I was kind of OK with the fact that I may never have the chance to win."
His chance came at the end of a history-making race at the famed 21/2-mile Brickyard, where Kanaan knew he had to pounce at the green flag for the final restart with three laps to go. He did, zipping inside leader Ryan Hunter-Reay to roar to the lead -- where he wanted to be in case another caution came out.
"I knew I had to get the lead on the restart because it could be a yellow, which happened to me plenty of times here, and it did," Kanaan said. "How funny is life? The yellow was my best friend."
Kanaan had his fair share of chances to win at Indy but came up short time and time again.
"It's wonderful for him," said Mario Andretti, himself a victim of bad luck at Indy. "He's raced here long enough that he deserves it, no question."
The win for Kanaan and Vasser was celebrated throughout the paddock. Alex Zanardi, who came from Italy to watch the race and gave Kanaan one of his 2012 London Paralympics medals as good luck, wept behind the pit wall as Kanaan took the checkered flag.
"I tell you I'm starting to think (the medal) really works," said Zanardi, who lost his legs in a 2001 crash in Germany. "It's a dream come true to see Tony win, to see Jimmy Vasser win, my dear friend. I'm so happy, I'm so happy."
It was Vasser who brought Zanardi's medal to Kanaan before the race, telling his driver that Zanardi wanted him to rub it for good luck.
"I actually cuddled with the thing," Kanaan admitted.
Bay Area native Vasser, caught in the middle as a driver during the political fighting in open-wheel racing, only got the chance to run Indy eight times and not during his prime.
"I never won it as a driver, so I had to hire the right guy to do it, get a baby Borg on my shelf," said Vasser, referring to the winner's Borg-Warner trophy.
Carlos Munoz, a 21-year-old in his first IndyCar start, finished second and Hunter-Reay was third.
"T.K. is such a fan favorite, absolutely, it's great to see him win it. If anybody is going to win it in the field, he's one of the few I'd like to see other than myself," Hunter-Reay said. "We were leading on that last restart, I knew I was a sitting duck"
Franchitti brought out the caution seconds after Kanaan passed Hunter-Reay for the last of 68 lead changes -- exactly double last year's record.
On the final lap, the leaders came to the finish line all bunched up around Kanaan, saluting the IndyCar stalwart. That was about as slow as anyone had driven all day. The average speed was 187.433 mph, another Indy record.
"It was a hell of a race," Mario Andretti said. "It's unbelievable racing, the best I've seen in years."
Kevin Harvick wins the Coca-Cola 600, a race that has 10 spectators injured. PAGE 3


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Location: Cereal Disease Laboratory
Project Number: 5062-21220-021-08
Start Date: Feb 01, 2011
End Date: Dec 31, 2016
Test wheat germplasm (6,0000 entries) from core collection at NSGC-USDA-ARS Aberdeen for resistance to wheat leaf rust in greenhouse and field plot tests. Spring wheat lines (ca. 2500) will be grown in St. Paul, Minnesota and evaluated for field resistance over two years to a mixture of current leaf rust races. 2,500 winter wheat lines will be evaluated over two years in plots at Castroville, Texas. 500 entries selected for drought tolerance, and 500 entries selected for leaf rust resistance will also be tested for resistance in field plot tests. All entries will be tested as seedling plants in greenhouse tests with a mixture of leaf rust races to determine the presence of effective seedling resistance genes. Phenotype data from field plot tests and seedling tests will be used to determine which entries have effective adult plant resistance and which have effective seedling resistance. The rust data will be combined with the single nucleotide polymorphism genotype data for all entries generated by USDA-ARS Wheat genotyping labs for association mapping to identify new genes for leaf rust resistance.


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PLEASANTON -- Safeway's net income jumped 13 percent in the final three months of 2012, reaffirming the prowess of the nation's second-largest supermarket chain despite tough competition from big-box grocers like Walmart and the popularity of niche stores like Trader Joe's.
The company credited the growing popularity of its customer loyalty program, "Just for U," for the gains. The program, which has about 5.4 million cardholders, offers digital coupons and individualized deals based on a consumer's past purchases.
After adjusting for benefits from a legal settlement, Safeway's profit for the quarter ending Dec. 29 was 94 cents a share, compared with 67 cents a share in the same quarter the year before. The results handily beat Wall Street's forecast, which called for profit of 76 cents a share. Investors celebrated, driving shares up almost 15 percent after Safeway CEO Steve Burd's morning call with investors.
The Pleasanton-based company, which includes Safeway, Vons, Dominick's and other chains in the U.S. and Canada, saw fourth-quarter sales increase 1.2 percent to $13.8 billion. The boost came in part from higher gift- and prepaid-card sales, and Safeway also shed some costs when it closed its Genuardi's stores in the Northeast.
Net income for 2012 increased more than 15 percent from the year before, from about $517 million to $597 million.
Thursday's earnings announcement was the first since Burd, 63, announced his retirement last month. He will leave the company in May after two decades at the helm. It was also the first earnings call with Safeway's new chief financial officer, Peter Bocian, who replaced now-President Robert Edwards on Tuesday.
Burd said the strong gains Safeway has posted for the past three quarters will continue after his departure. Company executives said the start of 2013 has been profitable and gains will continue as Safeway grows Just for U, which is gaining about 50,000 customers a week.
With the popularity of Just for U digital coupons, which customers can receive on their iPad and smartphone, Burd said Safeway may soon do away with the old paper coupons. The discounts knock 10 percent to 20 percent off club card prices.
"Our best customers have become increasingly more loyal and buying more items per trip," Burd said. "That's been true now since the beginning of Just for U."
Said Burd: "We are feeling very good about 2013."
Contact Heather Somerville at 925-977-8418. Follow her at Twitter.com/heathersomervil.


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AUSTIN (October 7, 2012)--The voter registration deadline on Tuesday marks an important turning point in the Texas elections because while who turns out to vote may not affect the outcome of the presidential race, it could decide the winners of many legislative races.
According to the Texas secretary of state, about 4.5 million Republicans voted in the 2004 and 2008 presidential elections, but Democrats have not been as consistent.
In 2004, only 2.8 million Democrats voted for their presidential nominee, but in 2008, 3.5 million Democrats turned out for President Barack Obama.
The extra 700,000 votes changed the Legislature.
In 2004, Democrats took 54 out of 150 seats in the Texas House, but the number jumped to 74 seats after 2008.
When registration and turnout dropped in 2010, Republicans took 101 seats.


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Vintage watches
Oris Artelier Small Second, Pointer Date
A modern Classic The redesigned Artelier Small Second, Pointer Date combines the heritage of Oris' Pointer Date Models with a modern, contemporary twist. The distinctively shaped watch case features gradually bent horns, providing the perfect fit to the wrist and a smooth continuation with the bracelet.
- Case Oris Artelier, 42.00 mm, 1.654 inches, Stainless steel
Material Multi-piece stainless steel caseSize 42.00 mm, 1.654 inchesTop Glass Sapphire, domed on both sides, anti-reflective coating insideCase Back Stainless steel, fixed with screws, see-through mineral glassOperating Devices Stainless steel crownWater Resistance 5 barInterhorn Width 22 mm
- Movement Automatic winding small second, pointer date
Developed by Oris.
Number Oris 744, base SW 220-1Dimensions Ø 25.60 mm, 11 1/2'''Functions Centre hands for hours and minutes, subsidiary second at 9 h, date by centre hand, date corrector, fine timing device and stop-secondWinding Automatic winding, bi-directionally rotating red rotorPower-Reserve 38 hrsVibrations 28'800 A/h, 4 HzJewels 28
- Dial Silver
Material Silver guilloche dialLuminous Material Hands Superluminova C3
- Strap/Bracelet Leather
Material Dark brown leather strap, stainless steel folding clasp
- Reference 01 744 7665 4051-07 5 22 70FC


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Exotic Ecuador
Quito, Otavalo, Baños, Cotopaxi & the Amazon rainforest
This package is currently unavailable.
To be the first to know when we have more departures available, subscribe to our
|Itinerary at a Glance
Exotic Ecuador
|Quito & Otavalo
|Otavalo Excursion & Papallacta
|Papallacta & Amazon
|Baños & Patate
|Cotopaxi & Quito
|Depart Quito
|Small Group TourTravel with a small, intimate group of 15-24 likeminded travelers escorted by an English speaking guide and/or tour manager for some or all of your journey. More of these packages
24 travelers max, dedicated tour escorts & guides throughout
|Scheduled Dates
|Price Includes
|Quito, Otavalo, Banos. The Amazon rainforest, El Paillion del Diablo waterfall & Cotopaxi National Park
|Los Angeles (LAX), New York Kennedy (JFK), Miami (MIA), Washington Dulles (IAD), Chicago O'Hare (ORD), Boston (BOS); other gateways on request (flight schedule)
|What to Expect
|This fast-paced, escorted tour involves a significant amount of walking or hiking, often on uneven terrain, and reaches high altitudes requiring a high level of physical fitness to fully enjoy the trip. This tour also includes long scenic drives between destinations and may have limited rest stops.
|Already Booked?
|Find everything you need to know before you go, including how to pay your balance due, passport & visa requirements, flight information, weather, and more.
Discover the wonders of Ecuador, a remarkable collection of landscapes, people, cultures, animals, plants, and more. Our Exotic Ecuador tour covers the highlights of this incredibly diverse country. You'll visit the capital city and UNESCO World Heritage Center of Quito, the colorful and bustling Otavalo market, the natural springs in Baños, the volcanic peaks of Cotopaxi National Park, and the world's most biologically diverse rainforest—the Amazon.
Our package includes roundtrip flights from Miami, great hotels, most meals and a comprehensive, fully-guided touring program, all for unbeatable prices. With prices like this, our Exotic Ecuador adventure is sure to sell out quickly, so be sure to reserve your space soon!
Dates, Prices & Options
Sorry, there are no currently available tour dates.
Detailed Itinerary
Day 1: USA/Quito. Your exciting tour to Ecuador begins today as you depart for Quito, Ecuador's capital city. Your guide will meet you upon arrival and escort you to your hotel. Accommodations: Sheraton Quito Hotel or Radisson Royal Quito or similar.
Day 2: Quito & Otavalo. Arguably among the loveliest of South American cities, Quito enjoys a spectacular setting surrounded by mountains and several snow-capped volcanoes, including the still-active Mt. Pichincha. The origins of the city date back to the first millennium, when the Quitu tribe occupied the area.
After breakfast, begin a panoramic tour of the city. In the modern city, visit the Legislative Palace and Alameda Park, containing the oldest observatory in South America. Continue on to Quito's beautiful and charming Old Town. Here you'll find blocks of colonial architecture dating to the early 1500's when the Spanish founded the city, now a UNESCO World Heritage site. Vintage facades line the streets and large open plazas are surrounded by cathedrals and stately public buildings. Even more breathtaking than the exteriors are the interiors of some of the buildings, particularly the churches, many of which gleam with real gold leaf. Visit the Monastery of San Francisco, Quito's oldest church. Built in the 16th century, the monastery is an exact replica of the Escorial Palace of Madrid.
Conclude your tour with a stop at the Equatorial Monument, the Mitad del Mundo ("Middle of the World"), commemorating the exact place where Charles Marie de la Condamine established the Equator, where you can stand with one foot in the northern and one in the southern hemisphere. Later today, depart for Otavalo. Accommodations: Puerto Lago or similar. Breakfast & dinner provided.
Day 3: Otavalo Excursion & Papallacta. Today you'll experience Otavalo, whose beauty lies in its people, the Otavaleño Indians, and their market, undoubtedly one of the best in all of Latin America. Unlike other indigenous people who have given up their traditional dress for jeans and t-shirts, Otavaleños are still easily identified by their distinctive dress: women wear intricately embroidered blouses and a wealth of beaded necklaces, while men have long, braided hair and wear calf-length white trousers, ponchos and sandals.
The market takes place in the main plaza, but don't hesitate to wander into the side streets, where the goods on display diversify and the prices are lower. Enjoy the cacophony of sounds as Andean pipe music mixes with Spanish and native Quechua voices, complemented by an explosion of color from the many fabric, fruit and other stalls.
Later this afternoon, continue to explore other nearby villages: Cotacachi, famous for its leatherwork, and Peguche, known for its traditional weavings.
Travel along the Andes Mountain range to Papallacta, a small town tucked away in a high Andean valley at the entrance to the Amazon jungle. Enjoy a relaxing stay at your spa-resort, located around hot thermal springs. Accommodations: Termas de Papallacta or similar. Breakfast provided.
Day 4: Papallacta & Amazon. The Amazonian segment of your tour begins after breakfast today as you set out along a scenic stretch of road overlooking lush green valleys and sparkling waterfalls.
Arrive at Punta Ahuano, a tiny port town on the north bank of the Napo River, where piraguas (canoes) await you for a short ride downstream to your lodge. After check-in, sip a refreshing welcome cocktail as you watch the sunset. Accommodations: Casa del Suizo or similar. Breakfast, lunch & dinner provided.
Day 5: Amazon. Enjoy a full day exploring the wonders of the Napo River area. Your tour guide will present two options after your walk through the jungle to help you maximize your stay. The first option, for wildlife aficionados, is a tour to Amazoonico, a rescue center for wounded and displaced tropical rainforest animals. You'll be able to observe coatis, tapirs, and several species of monkey, snakes, and a variety of birds, many of which wander around freely! The second option, for adventure seekers, is an ultimate rafting experience on the Napo River. Not only will you have the chance to enjoy a refreshing ride down this Amazonian tributary, you'll actually learn how to make your own raft by tying balsa logs together. You will decide, together with your group members which program the group will take.
Later in the day, enjoy a unique opportunity to visit a local Quechua family who will explain various aspects of their traditional culture, including a special lesson on making chicha, a beverage typical of the region.
Or, if you are in the mood for a more laid-back afternoon, we recommend a stroll through the artisan village of Ahuano, where you can watch traditional Quechua ceramics being created. (Excursions are provided on a group basis only.) Breakfast, lunch & dinner provided.
Day 6: Baños & Patate. After breakfast, set out in canoes again to return to La Punta. Continue by coach to Puyo, the most important city in Ecuador's Oriente region. En route, you'll visit the spectacular Rio Verde falls, better known as El Pailón del Diablo (The Devil's Cauldron). Enjoy lunch at a local restaurant.
Then head to nearby Baños, nestled in a lush valley at the foot of the Tungurahua volacano, famous for the hot springs that give it its name (baths).
The mild climate, verdant landscape, and mineral-rich natural springs in and around Baños make it an oasis of tranquility and relaxation. Sparkling waterfalls, rolling hills, and scenic bridges complete this picturesque setting. Be sure to sample some of the town's trademark taffy, called melcocha.
The final stop on today's tour is Patate, known for its picturesque location on the Patate River, its excellent grape cultivation, and the production of some of the best "aguardiente" liquor in the highlands. Accommodations: Hacienda Leito Los Llanganates or similar. Breakfast, lunch & dinner provided.
Day 7: Cotopaxi & Quito. Today's excursion takes you to another one of Ecuador's treasures, Cotopaxi National Park, home to several volcanoes, including Cotopaxi, the highest active volcano in the world (19,500 feet above sea level). Spanning an impressive 84,000 acres, this natural reserve protects a diverse array of flora and fauna, including llamas, deer, wild horses, as well as many rare species endemic to the region. Be sure to keep your eyes peeled and your cameras ready for a lucky sighting of the mythical Andean condor.
This afternoon, begin the return journey to Quito and later tonight, enjoy a farewell dinner with your travel companions at a local restaurant. Accommodations: Sheraton Quito Hotel or Radisson Royal Quito or similar. Breakfast & dinner provided.
Day 8: Depart Quito. Today bid adios to Ecuador as you transfer to the airport to board your return flight to the USA. Depending on your flight schedule, optional tours may be available for purchase locally. Late check-out at the hotel is also available for a supplement for flights departing Quito this evening. (See Dates & Prices). Breakfast provided.
I just returned from Ecuador on a Friendly Planet tour, and I cannot even begin to express how impressed I am with Friendly Planet. The trip was amazing, and we did more than I could imagine in 7 days. I have been on trips with other organizers before, but this was by far the most organized and well-led trip I have been on. Our tour guide was phenomenal, and everything ran right on schedule, with unbelievable accommodations, an abundance of delicious meals, and incredible scenery everywhere. I would absolutely recommend Friendly Planet to other travelers, and look forward to traveling with them again in the future.
Tamara Marks-Moses, Houston, TX
Before You Book
- Do I need a visa or any other documents? Please review the requirements about which documents you need before you travel.
- Should I get travel insurance? You can purchase our travel insurance coverage with your deposit or final payment. It may not be purchased before then.
- What's the fine print? Read the terms & conditions for this package.
- I'm traveling solo. Can you help me find a roommate? Yes, you can connect with other travelers to share a room and avoid single occupancy rates.
- Can I bring my kids? Are there any age restrictions? To book this package, you must be 21 or older. Your traveling companions must be 8 or older at the time of travel.
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Important Travelers Note
The high altitudes reached on this trip (Quito is at 9,200 feet above sea level) and the amount of walking involved, often on uneven terrain, requires that you be in good physical condition to fully enjoy the trip. We strongly suggest that you consult your physician if you have any concers regarding your ability to handle these conditions.


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SAN FRANCISCO -- Jeremy Lin is no longer the overachiever from Palo Alto. That was so evident on Thursday at Madame Tussauds, when his wax statue was revealed. In the same wing as Joe Montana, Tiger Woods and Muhammad Ali.
"This is almost too real," Lin said, staring at the life-size figurine of himself dunking in a Los Angeles Lakers uniform.
Once again, Lin finds himself on the big stage. Sure, Kobe Bryant will dominate the attention, but Lin won't be able to hide from the bright lights of Hollywood. He won't be able to escape the pressure to perform.
But after stints with the Warriors, where his garbage time drew ovations; in New York, where Linsanity made him a global star; and Houston, where his salary brought him constant scrutiny, Lin has come to grips that this is his reality.
The first decade or so of his basketball career, Lin was just a guy. The pinnacle of his career was supposed to be when he led Palo Alto High to a Division II state title in 2006.
Those days are gone. As much as he may miss the anonymity, the luxury of being the underdog, that's not his lot anymore. The low-key kid has accepted his calling to the big time.
So he heads to the Lakers, on the final year of his contract, needing to produce under the heat of the magnifying glass.
"It's incredible. It's a blessing," said Lin, who turns 26 on Saturday. "I am a lot more comfortable now than I was in the beginning. Going into my fifth year, I'm able to handle that now more than ever. I put more pressure on myself now than what I feel from the outside."
It's a raw deal in some respects. Lin will probably never be appreciated nationally the way he actually should be -- as a productive NBA guard. Like many others, he has some bankable skills to go with some weaknesses. From a purely basketball perspective, he has become an established player capable of contributing to a good team. He can even take over games here and there, especially if used right.
That's a significant accomplishment for an undrafted rookie out of Harvard. Especially when you consider he broke away from the typical career path of a suburban Asian kid with an Ivy League degree.
Yet it's never just about basketball with Lin. Not since he took the world by storm with Linsanity in 2012.
Now, he's more known as the guy who can't catch lightning in a bottle twice. He's judged under the context of international reach and endorsement clout. This is likely Lin's reality for the rest of his playing career. Having to live up to hype. Having to exist perennially in the spotlight. And Lin said he's grown comfortable with that truth.
He'd better be. He's a Laker now.
"It's very weird. At first I was like 'Whoa,' " Lin, who learned of the trade while he was overseas. "A lot of my friends and family are diehard Warriors fans, as I was growing up. But I appreciate California so much more now that I've been everywhere else."
His stint in Houston was considered a disappointment, ending with the Rockets courting Carmelo Anthony with billboards featuring the Knicks star in Lin's number.
Of course, Lin lands in L.A. In one of the largest Chinese-American populations in the nation, where he is sure to be treated as a rock star. On one of the NBA's storied franchises. Next to Bryant, one of the league's biggest stars ever, who is making a much-anticipated comeback from injury.
And Lin's playing on the final season of the three-year, $25 million he signed with the Rockets. Which means he really needs to show what he can do.
Somehow, Lin always finds himself on the main stage, with no idea of what will happen next.
"My NBA career has been anything but certain, anything but stable," Lin said. "I'm kind of used to it now."
Read Marcus Thompson II's blog at blogs.mercurynews.com/thompson. Contact him at firstname.lastname@example.com. Follow him on Twitter at twitter.com/ThompsonScribe.


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Two barns destroyed in farm fire
Saturday blaze kept firefighters on scene for hours
January 21, 2013
FEARING TOWNSHIP — No people or animals were injured when two barns and several pieces of farm equipment were destroyed by fire on a farm at 640 Stanleyville Narrows Road around 8:15 p.m. Saturday....
Good points and rememberances jbennett. I don't know if that applies here since the fire cause is not yet determined but this was a very old Ohio homestead that a millionaire bought for fun, so it's possible that he and the help didn't know the dangers of spontaneous combustion.
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Sorry for the loss, but my Grandpa always told us kids to pack those hay bales tight so no air can get between them. No air, no fires. These round bales should never be stored in or near any buildings just because of that. He also would feel the hay every day for heat and a couple of times he tossed a bale outside and would bust it open. Sure enough there would be a hot spot that would burst into flames when it got air. He just had a feel for that I guess.
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On the front page of the Devils Lake Journal for Monday, July 21 you will find what's "Coming in print," what's only found on our website today and a whole lot more.
Coming in print: Recaps of the Devils Lake City Commission and the Devils Lake School Board meetings.
On the web: Photo gallery from the AYA tournament
Location, ST | website.com


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…and congrats to Anna, the winner of the Red Flower Sweet Alyssum giveaway.
Painting by Bishop Lennon at etsy.
Natural Perfume and Beauty Blog
OMG! So damn cute! I have to say that I saw a lot of sea lions in the Galapagos, and they were never that friendly towards each other!
Happy Valentine's to you! (belatedly)
I hope the renovation(s) is/are carrying on smoothly!


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Join us for a unique and special small town celebration to start the holiday season. Culpeper begins the Holiday Season on Sunday, November 18th with our annual downtown Holiday Open House! Merchants will have their stores all trimmed and decorated for the holidays.
You are sure to find unique and perfect Christmas gifts in our specialty shops located in Historic Downtown Culpeper VA. If you haven't been to Culpeper in awhile, you'll love the great new shops that have opened. It is foodie heaven!
Before heading back to our romantic Virginia bed and breakfast, join in singing Christmas carols with the Blue Ridge Chorale at the Community Tree Lighting at the Depot at 5:30 p.m. There will be warm apple cider and cookies offered by local Girl Scouts. Make sure to keep an eye out for the Big Guy dressed in red! Stay for the weekend with us at our Virginia Inn, and enjoy some fine food, wine, and get your holiday spirit on.


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#Seawolves Weekly Wrap - Sept. 30-Oct. 6
Look back at the week that was in Stony Brook Athletics.
Football begins spring practice Wednesday
Seawolves will hold 15 workouts, including Spring Game on April 21
Get to know CAA Football
Facts and figures on Stony Brook Football's new home in 2013.
Stony Brook to join CAA Football in 2013
A new era of Stony Brook Football in the premier FCS conference to begin in 2013.
Receptions: 4, at Buffalo (9/14/13)
2013: Played in six games ... 10 catches for 167 yards and a touchdown ...DNP at James Madison (11/16), vs. Richmond (11/9), at Maine (11/2), vs. New Hampshire (10/26) and at Colgate (10/12) ... career-high 77 yards and a touchdown vs. Bryant (10/5) ... four receptions for 49 yards at Buffalo (9/14) ... made three catches for 41 yards at Rhode Island (9/7).
2012: Saw action in all 13 games ... majority of time came on special teams ... also saw time at wide receiver ... played vs. Colgate (9/22) and at Syracuse (9/15) ... made a tackle on special teams vs. Pace (9/8) ... saw action vs. Central Connecticut (9/1).
2011: Played in nine games ... made three tackles at Gardner-Webb (11/12) ... made two tackles vs. St. Anselm (10/15) ... saw first action of the season at Buffalo (9/10).
2010: Played in eight games ... saw action against Presbyterian (11/6) and Charleston Southern (10/30) ... one tackle at Coastal Carolina (10/23) ... had a tackle and first collegiate interception vs. VMI (10/9) ... saw action on special teams against UMass (9/25) and at Brown (9/18) ... made collegiate debut against American International (9/11).
High School: A 2010 graduate of Poly Prep Day School in Brooklyn ... three-year letterwinner for the Blue Devils ... first team all-New York City and all-Brooklyn by New York Daily News and New York Post ... Class A second team all-New York State on offense ... recorded 20 touchdowns as a senior (5 passing, 6 running, 6 interceptions, 2 kick return and 1 punt return) ... also lettered in track ... played for New York City in 2010 Outback Steakhouse Empire Challenge.
Personal: Devante Wheeler ... born June 15, 1992 in Brooklyn, New York ... son of Chris Legree and Vena Wheeler ... has two siblings ... father played football at Pittsburgh ... cousin, David, played football at Hampton and cousin, Jeff, played at the College of the Sequoias.


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Solar Charge ControllersHave you wondered if you can make use of solar power on your road trip? Solar technology has advanced so much that it has become a viable option for residential installation in sunny areas. While you can't guarantee that your RV will be parked in a sunny spot, you can make use of the sun's beams when you are.
Camping world has solar charge controllers ideal for RVs because they can use power absorbed by solar panels for powering your essentials in an emergency. Some kits require a converter while others provide AC outlets you can plug into. How useful your solar kit will be will depend upon how much it can store. Make sure you have enough batteries to take care of your basic needs if traditional power goes out.


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The U.S. Attorney's Office for the Middle District of Pennsylvania announced Thursday a Scranton man has pleaded guilty to attempting to entice a minor to engage in illegal sexual conduct.
Lewis John Davies, 46, admitted to using a computer to attempt to persuade a minor to engage in sexual acts with him between April and June 2008.
Davies was indicted by a federal grand jury in June 2008 as a result of an investigation by the Federal Bureau of Investigation and the Scranton Police Department, according to a news release from the U.S. Department of Justice.
Davies will be sentenced to serve between 66 and 78 months in prison, followed by five years of supervised probation. He also must comply with sex offender registration and treatment requirements.
Davies agreed to forfeit computers and related material used in the commission of the crime to the U.S.
The case was brought as part of Project Safe Childhood, a nationwide initiative launched in May 2006 by the Department of Justice to combat the growing epidemic of child sexual exploitation and abuse, the release said. Led by the U.S. Attorneys' Offices and the Criminal Division's Child Exploitation and Obscenity Section, Project Safe Childhood marshals federal, state and local resources to locate, apprehend, and prosecute individuals who sexually exploit children, and to identify and rescue victims.
For more information on Internet safety education, visit the resources tab on the Department of Justice's website:
Location, ST | website.com


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Definition of mandate in English:
1An official order or commission to do something: a mandate to seek the release of political prisoners
More example sentences
- Even some local trade officials ignored the new mandates to recruit women.
- Although my official mandate was to study Pakistani farmers, I was obliged to give equal attention to foresters.
- The Human Rights Commission has the mandate to receive and investigate allegations of discrimination.
instruction, directive, decree, command, order, injunction, edict, charge, commission, bidding, ruling, fiat
formal ordinance
1.1 Law A commission by which a party is entrusted to perform a service, especially without payment and with indemnity against loss by that party.
Example sentences
- In two of the four cases the solicitors received signed mandates from the purported owners for the funds to be telegraphically transferred to a third party.
- In carrying out its mandate, the Commission receives, analyses, and investigates individual petitions alleging violations of human rights.
- A Call Center for tourist information is in the works, and tourist police have a mandate to provide service and protection for visitors.
1.2US Law An order from an appellate court to a lower court to take a specific action.
Example sentences
- He also put in place a process to carry out the Court's mandate.
1.3A written authority enabling someone to carry out transactions on another's bank account.
Example sentences
- A forged cheque is not a valid mandate, and the bank cannot debit the customer's account.
- If that were right one would expect to see wives being independently advised before signing a typical mandate for a joint account.
- He showed his value pretty quickly, pointing out that banks must have a legal mandate to debit someone's account.
1.4 historical A commission from the League of Nations to a member state to administer a territory: the end of the British mandate in Palestine
More example sentences
- For the next 25 years, Syria was governed by French colonial administrators under a mandate from the League of Nations.
- Another category of dependent imperial territory was formed by League of Nations mandates.
- After the war, Japan continued to rule the islands under a mandate from the League of Nations.
2The authority to carry out a policy or course of action, regarded as given by the electorate to a candidate or party that is victorious in an election: a sick leader living beyond his mandate
More example sentences
- Newly elected ministers invariably choose to regard an election victory as conferring a mandate on their policies.
- Perhaps politicians should seek a new mandate from the electorate if they are unable to fulfil their promises.
- The ones who win and form the next government would thus have the mandate to pursue their policies and programmes.
authority, approval, acceptance, ratification, endorsement, sanction, authorization
2.1Canadian A period during which a government is in power.
Example sentences
- Third parties may not always directly influence an election, but they do set the tone for what is discussed and start the next mandate off on a particular foot.
- In August 2002, he announced that he would not seek a fourth mandate, but would serve until 2004.
verb[with object]
1Give (someone) authority to act in a certain way: other colleges have mandated coed fraternities
More example sentences
- Having made this judgment, the Security Council may then mandate the US and its allies to use force in order to remove him.
- With the money, it will acquire and restructure more mills, as mandated by the State Council.
- Well, the problem here is, the ballot initiatives mandate something like 70 percent of the spending in the budget.
instruct, order, direct, command, tell, require, charge, call on
1.1Require (something) to be done; make mandatory: the government began mandating better car safety
More example sentences
- Current Army requirements mandate change in order to move into the future.
- For such patients, it may be unrealistic to mandate abstinence as a requirement for treatment.
- The federal government has begun mandating it, and they insist that their architects earn at least a bronze rating.
make mandatory, legislate, authorize, require by law;
Early 16th century: from Latin mandatum 'something commanded', neuter past participle of mandare, from manus 'hand' + dare 'give'. sense 2 of the noun has been influenced by French mandat.
Words that rhyme with mandateabate, ablate, aerate, ait, await, backdate, bait, bate, berate, castrate, collate, conflate, crate, create, cremate, date, deflate, dictate, dilate, distraite, donate, downstate, eight, elate, equate, estate, fate, fête, fixate, freight, frustrate, gait, gate, gestate, gradate, grate, great, gyrate, hate, hydrate, inflate, innate, interrelate, interstate, irate, Kate, Kuwait, lactate, late, locate, lustrate, mate, migrate, misdate, misstate, mistranslate, mutate, narrate, negate, notate, orate, ornate, Pate, placate, plate, prate, prorate, prostrate, pulsate, pupate, quadrate, rate, rotate, sate, sedate, serrate, short weight, skate, slate, spate, spectate, spruit, stagnate, state, straight, strait, Tate, tête-à-tête, Thwaite, translate, translocate, transmigrate, truncate, underrate, understate, underweight, update, uprate, upstate, up-to-date, vacate, vibrate, wait, weight
For editors and proofreaders
Syllabification: man·date
Definition of mandate in:
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UPDATE: Lockheed Martin to close plant; 57 jobs lost
Published: Friday, January 18, 2013 at 12:53 p.m.
Last Modified: Friday, January 18, 2013 at 2:16 p.m.
MANATEE COUNTY - Lockheed Martin Corp. plans to close its Gyrocam Systems plant in southern Manatee County later this winter, eliminating 57 local jobs.
The giant defense contractor notified state employment officials last week that it was permanently shutting down the plant on March 15.
A company spokeswoman said Friday that 22 of the employees will transfer to plants in Orlando or Ocala, where the Gyrocam work is being absorbed.
Gyrocam's long-range optical intelligence, surveillance and reconnaissance — or "ISR" — products have been used primarily on ground vehicles by the U.S. Army, Marine Corps and Air Force.
In September the company announced it had won a $333 million, two-year contract to provide spare and repair parts for the systems it had created for the Army that can spot roadside and other threats.
Gyrocam, then known as Aerial Films Inc., moved here from New Jersey in 2000. At the time, the company focused on a zoom video camera system stabilized by a gyroscope and mounted on the bellies of TV news helicopters.
After beefing up the systems with night vision and thermal imaging, the renamed Gyrocam expanded into defense work. Bethesda, Md.-based Lockheed bought the company in 2009.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Main Content
Get ready for a run or a day out at the rink with this Travel and Training pullover hoodie from Reebok. The team-colored hems and Winnipeg Jets lettering will ensure that your team loyalty is unmistakable. Featuring a soft fleece lining and Reebok's PlayDry technology that moves moisture away from the skin to keep you dry and ventilated, this hoodie will keep you comfortable while your Jets easily defeat the competition. Not only will you be super cozy, but you can also safely stow your music player or phone away in a pouch in the front pocket designed to hold your devices. Enjoy your evening at the rink, but don't forget to take your Winnipeg spirit with you!
- 100% Polyester fabric
- Front pouch pocket
- Imported
- Officially licensed NHL product
- PlayDry technology for ultimate comfort
- Reebok's Center Ice collection
- Screen print graphics
- Tagless collar
- Lightweight pullover hoodie
- Long sleeve
- Imported
- Brand: Reebok
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Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
Customized items can be personalized with options such as your name, your favorite number, and/or designs. Some options may be limited by league rules.


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Definition of honeycomb in English:
1A structure of hexagonal cells of wax, made by bees to store honey and eggs.
Example sentences
- The surplus is stored away in the honeycomb to sustain the bees throughout the flowerless months of autumn and winter.
- Once the bee has made it home again, it barfs up the half-digested nectar and stores it in honeycombs.
- Other topics which Maclaurin wrote on were the annular eclipse of the sun in 1737 and the structure of bees' honeycombs.
2A structure of adjoining cavities or cells: a honeycomb of caves
More example sentences
- The rock was pitted with a honeycomb of caves, each formerly the cell of a Byzantine monk.
- A spin-off company is expected to market the technology and to produce the structural honeycomb products.
- The foam has a honeycomb structure and is completely recyclable.
2.1A mass of cavities produced by corrosion or dissolution: [as modifier]: honeycomb weathering
More example sentences
- They have eaten through the plaster itself to the point where it is no more than a rotting honeycomb, a huge housing system for an entire ecosystem of bugs.
- The lumps are a result of the interaction of the bacteria dissolving the bone, and the bone trying to repair itself, leaving a honeycomb effect.
- Sometimes the entire face of the stone can be lost leaving a honeycomb of cement mortar standing proud, forming a water trap and increasing the risk of frost damage.
2.2A raised hexagonal or cellular pattern on the face of a fabric.
Example sentences
- One of the throw pillows had a honeycomb pattern that made me dizzy.
- The final winner was Eriskay fabric, a worsted material with an unusual honeycomb texture, designed by Catherine Murray from Bute Fabrics.
- The honeycomb texture is recessed rather than raised, and is available in a wide range of colours from rich vibrant reds, yellows, oranges, blues and greens to more unexpected pastel shades.
3Tripe from the second stomach of a ruminant.
Example sentences
- Tripe comes in four types; the fat part of the first belly and three different section of honeycomb from the second stomach.
verb[with object]
1Fill with cavities or tunnels: whole hillsides were honeycombed with mines
More example sentences
- The island, itself, is honeycombed with tunnels.
- It still had a functional role in WW II, when the cliffs on which it stood were honeycombed with tunnels.
- The building will be honeycombed with courtyards, which will be planted with trees and shrubs, and there will be disabled access throughout.
1.1Infiltrate and undermine: their men honeycombed the army
More example sentences
- But it is not as evident as many news stories imply and all too many people suspect that the Archdiocese of Boston, or the Catholic Church, is honeycombed with pedophiles.
- They honeycombed the State Department and the Office of Strategic Services.
- They are honeycombed with Socialists - probably with Communists.
For editors and proofreaders
Syllabification: hon·ey·comb
Definition of honeycomb in:
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In some of his most expansive comments since his movie touched off a Washington firestorm, the screenwriter of "Zero Dark Thirty" defended his film as depicting torture accurately and said that a pending Senate investigation brought him "a chill."
"We've been accused of defending torture because there are disagreements in some quarters as to exactly which detainee undergoing exactly which form of interrogation first produced the lead that led to (Osama) bin Laden and thus ... we shouldn't have included it," Mark Boal said. "I can't understand the logic to that. If we left the torture out, we'd be whitewashing history. Interrogations were clearly part of how this lead developed."
Political uproar
Speaking earlier this week to an audience at a Loyola Marymount University event about the First Amendment, Boal said he was frightened by the reaction on Capitol Hill, which for him conjured the dark specter of McCarthyism.
"You know, it's fine for some senators to say they think I'm wrong about some of the scenes depicted in the movie. It's an entirely different matter for them to launch an investigation over it," he said, adding, "As far as I know, Congress hasn't launched a formal investigation of filmmaking since the House Un-American Activities Committee did so in the late 1940s. I really don't think we need a remake of that."
"Zero Dark Thirty" portrays the CIA's pursuit of bin Laden over nearly a decade, and begins with a form of harsh interrogation that ultimately led to one of the breakthroughs in the manhunt.
Critics and awards voters have largely embraced the movie -- the film has garnered five Oscar nominations, including best picture -- but U.S. Sen. Dianne Feinstein, D-Calif., and other lawmakers from the Senate Intelligence Committee have criticized the movie for its depiction of torture as helping the CIA locate bin Laden. They have called for CIA officials to disclose the nature and extent of their contact with "Zero Dark Thirty" filmmakers in the development and production process.
Boal also has been hit by pundits and critics who say his movie seeks to have it both ways; at the talk, the writer cited a New Yorker review that said the film wanted "to claim the authority of fact and the freedom of fiction."
In good company
Drawing comparisons with films that have faced criticism or negative reviews, Boal said he felt like he was in good company.
"Like other movies that have blended real events with created ones, in very different ratios -- from 'Bonnie and Clyde' to 'The French Connection' to 'JFK' -- we've managed to stir the pot a bit," Boal said. "When it came out, 'A Clockwork Orange' -- banned in the U.K. -- was jumped on, too. So was 'One Flew Over the Cuckoo's Nest' (and) 'The Deer Hunter.' ... However unintentionally, 'Zero Dark Thirty' has joined a club of films that have come under fierce attack in their time."
Boal said the immediacy of the movie was, in his view, responsible for the heated reaction, "Imagine if 'All the President's Men' had come out while Nixon was still in office," said Boal, who described "Zero Dark Thirty" as "front-page art." Though there have been a number of long-form print explorations of the raid, Boal said his film broke ground other media hadn't.
"Despite the overwhelming coverage through the media of the mission in Abbottabad (Pakistan)," he said, "the central role of the team that hunted bin Laden for 10 years was told for the first time not in a newspaper or a book, or even online. It was told at the movies. That may be a first."
Boal had previously offered some reaction to the controversy, notably at a New York Film Critics Circle event last month, but has mostly kept his comments to prepared statements. With the film now in wide release -- it has grossed $78 million through this past weekend -- and Oscar balloting set to begin this week, the filmmakers appear to be relaxing their self-imposed media silence. As Boal was giving his address at Loyola Marymount, "Zero Dark Thirty" director Kathryn Bigelow was recording an appearance on "The Tonight Show."
Journalism meets film
In his speech, Boal also laid out a plan -- a "disruptive technology," he called it -- for what he said would give movies added heft by blending journalism and storytelling.
"For me, right now, the real power of filmmaking is found at the intersection of investigation and imagination, where reporting and creativity combine to offer something new," said the filmmaker, who has also set up a production company with the same purpose. "That's what Jon Stewart and Stephen Colbert do ... millions of people who might not otherwise pay as much -- or any -- attention to politics are dialed into political dialogue as a result."
Boal said he was personally opposed to torture, but that "Zero Dark Thirty" was trying to provoke thought more than offer a clear judgment -- a point he believes some of the movie's naysayers have failed to fully understand.
"Was (torture) morally correct? Was it wrong? I have my view. I happen to think it was dead wrong," he said. But —'Zero Dark Thirty' doesn't try to tell you what to think. It simply encourages you to think, and therein catch the conscience of the country."
'zero dark thirty'
Rating: R (for violence and language)
Cast: Jessica Chastain, Jason Clarke, Kyle Chandler and Joel Edgerton
Director: Kathryn Bigelow
Running time: 2 hours,
37 minutes


text:
On automobiles with bare roofs, Thule Traverse Fit Kits attach Thule Traverse Foot Packs to the roof of the car. Foot Packs hold the Load Bars, (both of which are sold separately). These car-specific Fit Kits come with 4 rubber pads and 4 metal clips. Refer to Thule's Fit Guide for total roof rack recommendations based on your car's make, model and year.
- Details
- Traverse Fit Kit 1585
- Compatibility
- Thule Traverse Foot Pack
- TOYOTA Corolla 4DR '03-08
- TOYOTA Corolla S 4DR '03-08


text:
Efficacy & Safety of ODSH (2-0, 3-0 Desulfated Heparin) in Patients With Metastatic Pancreatic Cancer Treated With Gemcitabine & Abraxane (PGPC1)
Recruitment status was Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Metastatic Pancreatic Cancer
Drug: Abraxane ( Nab-paclitaxel)
Drug: Gemcitabine
Drug: ODSH ( 2-O, 3-O Desulfated Heparin)
Drug: Abraxane ( nab-paclitaxel)
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Randomized Phase II Open Label Study to Assess the Efficacy & Safety of Gemcitabine + Abraxane® With or Without ODSH (2-0, 3-0 Desulfated Heparin) as First Line Treatment of Metastatic Pancreatic Cancer
- Progression-Free Survival (PFS) according to RECIST Guidelines. [ Time Frame: From Baseline to disease progression or death (whichever occurs first), assessed up to 9 months. ] [ Designated as safety issue: No ]Median Progression-Free Survival according to RECIST Guidelines Version 4.03
- Incidence of Adverse Events & Toxicity [CTCAE Version 4.03] [ Time Frame: From Baseline to disease progression, assessed up to 9 months ] [ Designated as safety issue: Yes ]Incidence of Adverse Events, laboratory test abnormalities and chemotherapy toxicity.
- Overall survival (OS). [ Time Frame: From Baseline to Death, assessed up to 9 months. ] [ Designated as safety issue: No ]Comparative OS among study arms at the end of the study.
- Objective Tumor Response [ Time Frame: From Baseline to disease progression or death (whichever occurs first), assessed up to 9 months. ] [ Designated as safety issue: No ]Overall Response Rate (Complete / Partial Responses), Duration of Response and Disease Control Rate will be assessed.
- ODSH Area Under Curve (AUC) [ Time Frame: Time Frame: 0, 15, 30, 45 and 60 minutes after the ODSH IV bolus and at 48 hours (steady state) during the ODSH IV continuous infusion. ] [ Designated as safety issue: Yes ]PK assessment of ODSH plasma concentration during ODSH IV bolus (4 time-points) and at the end of the ODSH 48-hour IV continuous infusion in 6 patients
|Estimated Enrollment:
|Study Start Date:
|November 2011
|Estimated Study Completion Date:
|March 2013
|Estimated Primary Completion Date:
|December 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Run-in
10 Subjects to be enrolled in the study to receive : gemcitabine + nab-paclitaxel + ODSH
Drug: Abraxane ( Nab-paclitaxel)
Nab-paclitaxel 125 mg/m2 administered IV over 30 minutes. Given weekly for 3 weeks followed by one week of rest.
Other Name: Nab-paclitaxel = AbraxaneDrug: Gemcitabine
Gemcitabine at 1000 mg/m2 administered IV over 30 minutes (after the nab-paclitaxel IV administration is complete). Gemcitabine to be administered weekly for 3 weeks followed by one week of rest.Drug: ODSH ( 2-O, 3-O Desulfated Heparin)
ODSH IV bolus at 4 mg/kg to be administered in 5 minutes immediately after completion of gemcitabine administration.
ODSH 48-h IV continuous infusion at 0.375 mg/kg/h should be started immediately after the ODSH IV bolus has been administered.
Other Name: ODSH = 2-O, 3-O Desulfated Heparin
Experimental: Arm A
25 patients to be enrolled to receive gemcitabine + nab-paclitaxel + ODSH
Drug: Abraxane ( Nab-paclitaxel)
Nab-paclitaxel 125 mg/m2 administered IV over 30 minutes. Nab-paclitaxel to be given weekly for 3 weeks followed by one week of rest.
Other Name: Abraxane = nab-paclitaxelDrug: Gemcitabine
Gemcitabine at 1000 mg/m2 over 30 minutes to be administered after the completion of Abraxane administration. Gemcitabine will be given weekly for 3 weeks followed by one week of rest.Drug: ODSH ( 2-O, 3-O Desulfated Heparin)
ODSH IV bolus at 4 mg/kg will be administered in 5 minutes immediately after completion of gemcitabine administration.
ODSH 48-h IV continuous infusion at 0.375 mg/kg/h should be started immediately after the ODSH IV bolus has been administered.
Other Name: ODSH = 2-O, 3-O desulfated heparin
Active Comparator: Arm B
25 patients will be enrolled in the study to receive gemcitabine + nab-paclitaxel
Drug: Abraxane ( nab-paclitaxel)
Nab-paclitaxel 125 mg/m2 administered IV over 30 minutes will be given weekly for 3 weeks followed by one week of rest.
Other Name: Abraxane = nab-paclitaxelDrug: Gemcitabine
Gemcitabine to be administered IV at 1000 mg/m2 over 30 minutes given weekly for 3 weeks followed by one week of rest
Detailed Description:
ODSH has demonstrated in vitro and in vivo inhibitory activity on mechanisms that are believed to play important roles in pancreatic cancer invasion, metastasis, and resistance to chemotherapy and radiation. Pancreatic cancer appears to have a dependence on autophagy, a regulated catabolic pathway to degrade and recycle cellular organelles and macromolecules. Autophagy appears to be largely driven by the binding of high mobility group box-1 protein (HMGB1) to the receptor for advanced glycation end-products (RAGE), which is strongly inhibited by ODSH. Autophagy appears to not only assist pancreatic cancer cells to survive in a hypoxic, relatively avascular environment, but also appears to play an important role in chemotherapy resistance. Other important biological activities promoting pancreatic cancer invasion and metastasis affected by ODSH include the inhibition of heparanase and the binding of tumor cells to endothelium and platelets mediated by the selectins. It is believed that these biological activities such as the inhibition of RAGE, heparanase, and selectin-mediated metastasis, can be inhibited by ODSH at dose levels that can safely be administered without clinically significant anticoagulation.
The standard of care of pancreatic cancer is evolving. It appears that two combination regimens, the "FOLFIRINOX" regimen (a combination of 5-fluorouracil, leucovorin, irinotecan and oxaliplatin) and the combination of gemcitabine + nab-paclitaxel, could have more activity than the previous standard treatment of gemcitabine alone.
Subjects with advanced metastatic pancreatic cancer that have not received chemotherapy, surgical or radiation treatments and have a good performance status will be eligible to participate in this study. 10 patients will be enrolled in a Run-in Period to receive gemcitabine + nab-paclitaxel +ODSH. PK sampling and safety assessments will be conducted to decide on the continuation to the Controlled Period of the study where 50 patients will be randomized at a 1:1 ratio to either of the two study arms: Arm A will receive gemcitabine + nab-paclitaxel + ODSH and Arm B will receive gemcitabine + nab-paclitaxel.
The primary endpoint of the study is mean progression free survival. The secondary endpoints consist of tumor response by RECIST criteria, overall survival at the end of the study and changes from baseline for CA19-9 marker, weight and plasma albumin.
|Ages Eligible for Study:
|18 Years to 75 Years (Adult, Senior)
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must have histologically confirmed adenocarcinoma of the pancreas that is metastatic and for which potential curative measures, such as resection of an isolated metastasis, are not available. Patients with islet cell neoplasms are excluded.
- Patient has one or more metastatic tumors measurable by CT scan AND a serum CA19-9 measurement > 2 times the upper limit of normal. Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as >20 mm with conventional techniques or as >10 mm with spiral CT scan.
- Male or non-pregnant and non-lactating female and ≥ 18 to ≤ 75 years of age. If a female patient is of child-bearing potential, she must have a negative serum pregnancy test documented within 72 hours prior to the first administration of study drug and on Day 1 of each cycle thereafter. If sexually active, the patient must agree to use contraception prior to study entry and for the duration of study participation.
- Patients must have received no prior radiotherapy or chemotherapy for metastatic disease. Patients who have received radiotherapy or chemotherapy as adjuvant o neo-adjuvant therapy for locally advanced disease six months or more prior to enrollment into this study are eligible.
- Patient has adequate biological parameters as demonstrated by the following blood counts at Screening (obtained ≤ 14 days prior to randomization) and at Baseline-Day 0: Absolute neutrophil count (ANC) ≥ 1.5 × 109/L; Platelet count ≥ 100,000/mm3 (100 × 109/L); Hemoglobin (Hgb) ≥ 9 g/dL.
Patient has the following blood chemistry levels at Screening (obtained ≤ 14 days prior to randomization) and at Baseline-Day 0:
- AST (SGOT), ALT (SGPT) ≤ 2.5 × upper limit of normal range (ULN), unless liver metastases are present, then ≤ 5 × ULN is allowed. Total bilirubin ≤ 1.5 × ULN.
- Serum creatinine (Cr) within normal limits or calculated clearance ≥ 60 mL/min/1.73 m2 for patients with creatinine (Cr) levels above or below the institutional normal value. If using Cr clearance, actual body weight should be used for calculating Cr clearance (e.g., using the Cockcroft-Gault formula).
- Patient has acceptable coagulation studies at Screening (obtained ≤14 days prior to randomization) as demonstrated by prothrombin time (PT) and partial thromboplastin time (PTT) within normal limits (± 15%).
- Patient has ECOG performance status ≤ 1.
Exclusion Criteria:
- Patient has brain metastases.
- Patient has only locally advanced disease.
- Patient has experienced an increase of ECOG to > 1 between Screening and Randomization.
- Patient requires continuous treatment with coumadin or other oral or parenteral anticoagulation (heparin, LMWH, heparinoids) to prevent or treat thromboembolic disease. The use of prophylactic antiplatelet drugs such as clopidogrel and aspirin are allowed before and during the study.
- Patient has active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy.
- Patient has undergone major surgery, other than diagnostic surgery (i.e.--surgery done to obtain a biopsy for diagnosis without removal of an organ), within 4 weeks prior to Randomization in this study.
- Patient has a history of allergy or hypersensitivity to any of the study drugs, their pharmaceutical class or any of their excipients.
- Patient has a concomitant serious medical or psychiatric illness that, in the opinion of the investigator, could compromise the patient's safety or the study data integrity.
- Patient is enrolled in any other clinical protocol or investigational trial involving administration of antineoplastic compounds for the treatment of metastatic pancreatic cancer.
- Patient is unwilling or unable to comply with study procedures.
- Nab-paclitaxel is metabolized by CYP2C8 and CYP3A4. Co-administration of substrates, inhibitors of CYP2C8 and/or CYP3A4 with nab-paclitaxel is not allowed. The following medications and substances are not allowed during the study: ritonavir, saquinavir, indinavir, nelfinavir, rifampicin, carbamazepine, phenytoin, efavirenz, or nevirapine, grapefruit (juice or seeds) or some herbals like St. John's wort.
- Subjects with risk factors for or a history of Torsades des Pointes (TdP), or a significant QT prolongation that in the opinion of the investigator may place the study subject at risk.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01461915
|Contact: Jocelyn Harmon, BS, CCRC
|(602) 358 8385
|Contact: Amy Stoll, MS, CCRP
|(602) 358-8319
|United States, Arizona
|Mayo Clinic Arizona
|Scottsdale, Arizona, United States, 85259
|Contact: Falicia Mallory 480-301-6072 email@example.com
|Principal Investigator: Mitesh Borad, MD
|United States, California
|Disney Family Cancer Center
|Burbank, California, United States, 91505
|Contact: Barbara Rolph, RN 818-847-3220 email@example.com
|Principal Investigator: Peter J Rosen, MD
|Marin Cancer Care
|Greenbrae, California, United States, 94904
|Scripps Clinic Torrey Pines ( Green Hospital)
|La Jolla, California, United States, 92037
|Contact: Jennifer Lashenr, RN 858-554-9379 email@example.com
|Principal Investigator: Darren Sigal, MD.
|United States, Florida
|Cleveland Clinic Florida
|Weston, Florida, United States, 33331
|Contact: Jessica Woodring, MBA, CAPM 954-659-5538 firstname.lastname@example.com
|Principal Investigator: Timmy Nguyen, MD
|United States, Illinois
|Loyola University Medical Center/Cardinal Bernardin Cancer Center
|Maywood, Illinois, United States, 60153
|Contact: Sandra Zakrewski, RN 708-327-2831 email@example.com
|Principal Investigator: Shelly S Lo, M.D.
|United States, Indiana
|Indiana University Health, Goshen Center for Cancer Care
|Goshen, Indiana, United States, 46526
|Contact: Rebecca Eickhoff, RN,BSN,OCN,CCRP 574 364 2649 firstname.lastname@example.com
|Principal Investigator: Alexander Starodub, MD
|United States, Louisiana
|Fesit-Weiller Cancer Center
|Shreveport, Louisiana, United States, 71130
|Contact: Stacy Moss, MEd, CCRC 318-813-1422 email@example.com
|Principal Investigator: Tannaz Armaghany, MD
|United States, Michigan
|Saint Mary's Health Care
|Grand Rapids, Michigan, United States, 49503
|Contact: Rosa M Bossi, BS, CCRP 616-685-5156 firstname.lastname@example.com
|Principal Investigator: Thomas E Gribbin, MD
|United States, Ohio
|Summa Health System - Cooper Cancer Center
|Akron, Ohio, United States, 44304
|Contact: Lynn Kaplan, RN 330-375-6121 email@example.com
|Principal Investigator: Sameer Mahesh, MD
|United States, Pennsylvania
|Thomas Jefferson University [Kimmel Cancer Center]
|Philadelphia, Pennsylvania, United States, 19107
|Contact: Deborah Kilpatrick, RN 215-955-0017 email@example.com
|Principal Investigator: Susan J Littman, MD
|Fox Chase Cancer Center
|Philadelphia, Pennsylvania, United States, 19111
|Contact: Alexis Dickens 215-214-3916 email@example.com
|Principal Investigator: Stephen Cohen, MD
|UPMC Cancer Center
|Pittsburgh, Pennsylvania, United States, 15232
|Contact: Sarah Rankin, BSN,RN,OCN 412-623-2677 email@example.com
|Principal Investigator: Nathan Bahary, M.D.
|United States, South Carolina
|Medical University of South Carolina Hollings Cancer Center
|Charleston, South Carolina, United States, 29425
|Contact: Alan Brisendine, CCRP 843-792-9007 firstname.lastname@example.com
|Principal Investigator: Steve Chin, MD
|United States, Texas
|University of Texas Medical Branch
|Galveston, Texas, United States, 77555
|Contact: Lisa Hernandez Garcia 409-747-2211 email@example.com
|Principal Investigator: Avi B Markowitz, MD.
|South Texas Oncology & Hematology
|San Antonio, Texas, United States, 78229
|Principal Investigator:
|Mitesh J Borad, MD
|Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic , Scottsdale Arizona
|Study Director:
|Stephen Marcus, MD
|ParinGenix Inc, Weston FL
Additional Information:
|Responsible Party:
|Cantex Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01461915 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 13, 2011
|Last Updated:
|November 9, 2012
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Cantex Pharmaceuticals:
Pancreatic Cancer
Additional relevant MeSH terms:
Calcium heparin
Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Digestive System Diseases
Pancreatic Diseases
Endocrine System Diseases
Albumin-Bound Paclitaxel
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Antimetabolites, Antineoplastic
Antiviral Agents
Anti-Infective Agents
Enzyme Inhibitors
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Fibrinolytic Agents
Fibrin Modulating Agents
ClinicalTrials.gov processed this record on August 24, 2016


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MANAGUA, Nicaragua - Overcoming a concerted U.S. drive to thwart his comeback, former Marxist revolutionary Daniel Ortega on Monday appeared headed to a clear victory in Nicaraguan presidential elections.
Fireworks punctuated the sky, and thousands of supporters whizzed through Managua's streets in pickups and motorcycles shouting ``Long live El Comandante!' after preliminary results released before dawn Monday gave Ortega a seven-point lead over his closest rival in the five-way race.
Fans waved a sea of Sandinista flags -- some in the traditional red-and-black stripe of Ortega's 1979 revolution that toppled the corrupt Somoza dynasty, others in pink, the campaign color he adopted to show he'd softened his Cold War ideology.
``It is God's miracle. Our savior has returned,' said Fernanda López, 76, tears of joy streaming down her face.


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16 Opinions
Oil diffusers:
This type of diffusers are popular to all for their low price. But, they don't accompany so much of features. Though they're very useful. This type of oil diffusers use fan or possibly type of heating element to discharge the perfume throughout the bedroom. They are very easy make use of and reasonably priced. They can also be very noiseless. And they use a reduced amount of oil comparing to the different low end diffuser..for more information go to our website.
A new, free, alternative is Evom which appears to cover everything that the iSquint of old does.
Thanks el cravito - it's a useful app, I hope someone can take it over.
The iSquint download (.dmg file) is still available from MacUpdate.
yeah i tried to use this the other day and it wouldn't work. :(
Appears to be no longer supported by developer (see Homepage link).
If you get one of those new flash card video cameras - you have to have this program to get the files into an iMovie friendly format.
I agree: very effective application. However, I'm not sure I'd love to see this kind of humor in all my Mac's applications.
Very great program. Thanks.
slow but nice
Page 1 of 2. 16 entries.


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Grit, chess, and how to think Mar 13 2014
Shane Parrish's excerpt and exploration of Paul Tough's How Children Succeed: Grit, Curiosity, and the Hidden Power of Character made me want to stop everything and read the book all the way through.
"Tell me about your game," Spiegel said. Sebastian flopped into the chair and handed her his notepad, where he'd recorded all the moves for both players in the game.
Sebastian explained that the other guy was simply better. "He had good skills," he said. "Good strategies."
And this is the point where many of us would simply say something along the lines of "did you do your best?," in which case the likely response is "Yes." Everyone is at least let off the hook. The teacher for ensuring students try their best, the student for having lost to someone better. Spiegel did not take this approach.
You may remember Tough's 2011 piece on grit in the NY Times Magazine.
The most critical missing piece, Randolph explained as we sat in his office last fall, is character -- those essential traits of mind and habit that were drilled into him at boarding school in England and that also have deep roots in American history. "Whether it's the pioneer in the Conestoga wagon or someone coming here in the 1920s from southern Italy, there was this idea in America that if you worked hard and you showed real grit, that you could be successful," he said. "Strangely, we've now forgotten that. People who have an easy time of things, who get 800s on their SAT's, I worry that those people get feedback that everything they're doing is great. And I think as a result, we are actually setting them up for long-term failure. When that person suddenly has to face up to a difficult moment, then I think they're screwed, to be honest. I don't think they've grown the capacities to be able to handle that."


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Allergies Health Center
Food Allergies and Food Intolerance
In this article
Differential Diagnoses For Food Allergies continued...
There are also natural substances, such as histamine, that can occur in foods and stimulate a reaction similar to an allergic reaction. For example, histamine can reach high levels in cheese, some wines, and in certain kinds of fish, particularly tuna and mackerel. In fish, histamine is believed to stem from bacterial contamination, particularly in fish that hasn't been refrigerated properly. If someone eats one of these foods with a high level of histamine, that person may have a reaction that strongly resembles an allergic reaction to food. This reaction is called histamine toxicity.
Another cause of food intolerance that is often confused with a food allergy is lactase deficiency, also known as lactose intolerance. This most common food intolerance affects at least one out of ten people. Lactase is an enzyme that is in the lining of the gut. This enzyme degrades lactose, which is in milk and other dairy products. If a person does not have enough lactase, the body cannot digest the lactose in most dairy products. Instead, the lactose is used by bacteria, gas is formed, and the person experiences bloating, abdominal pain, and sometimes diarrhea. There are a couple of diagnostic tests in which the patient ingests a specific amount of lactose and then the doctor measures the body's response by analyzing a blood sample.
Another type of food intolerance is an adverse reaction to certain products that are added to food to enhance taste, provide color, or protect against the growth of microorganisms. Compounds that are most frequently tied to adverse reactions that can be confused with food allergy are yellow dye number 5, monosodium glutamate, and sulfites. Yellow dye number 5 can cause hives, although rarely. Monosodium glutamate (MSG) is a flavor enhancer, and, when consumed in large amounts, can cause flushing, sensations of warmth, headache, facial pressure, chest pain, or feelings of detachment in some people. These transient reactions occur rapidly after eating large amounts of food to which MSG has been added.
Sulfites can occur naturally in foods or are added to enhance crispness or prevent mold growth. Sulfites in high concentrations sometimes pose problems for people with severe asthma. Sulfites can give off a gas called sulfur dioxide, which the asthmatic inhales while eating the sulfited food. This irritates the lungs and can send an asthmatic into severe bronchospasm, a constriction of the lungs. Such reactions led the FDA to ban sulfites as spray-on preservatives in fresh fruits and vegetables. But they are still used in some foods and are made naturally during the fermentation of wine, for example.
Today on WebMD
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Katie Beasley">
Green2Green is trying to purchase special wheelchairs for wounded veterans to help them feel normal again. (WRDW-TV / July 22, 2011)
News 12 at 6 o'clock / Friday July 22, 2011
EVANS, Ga. -- Most people take the simple use of healthy, working legs for granted, but many wounded warriors come home with injuries that take away the use of one or both legs.
Now, one local group is trying to give those men and women a little hope in the form of a unique wheelchair.
Green2Green is a nonprofit working to bring the game of golf to wounded warriors, and now they're not letting a handicap or injury get in the way.
Specialist Danny McGowan was injured last year in Afghanistan. He's confined to a wheelchair and says playing golf hasn't been much of a priority.
"We were hit by an IED and it damaged my truck. I sustained multiple injuries to my back and to my legs," McGowan said.
But thanks to a special wheelchair, McGowan can hit the greens again.
"It's been a long time for me, and doing it today, it felt great, it really felt great," he said.
In just more than a year, Green2Green has helped more than $2,000 injured soldiers play golf. From amputees to soldiers suffering from PTSD, they try to help them all.
"It's just finally something they can do to feel normal again and that's the biggest thing when they've come back from Iraq and Afghanistan, wherever they've come back from, they haven't had that sense of normalcy yet," said Dean Carrigan, chief development officer for Green2Green. "We've seen progress: The guys have gotten healthier and happier."
Now they're teaming up with Anthony Netto and Stand Up and Play to bring these special chairs to Augusta.
"Basically it stands you up and you can swing using your upper body and move around the golf course without using a golf cart," Carrigan said.
McGowan is excited about it and thinks others will be, too.
"Hopefully, it will be a good thing for a lot of people that are in wheelchairs to say, 'Hey, I can at least do that,'" he said.
Green2Green says it would love to purchase about 10 of these special chairs, which are more than $16,000 each, so they can help more soldiers like McGowan.
"It's showing me that I can perform something again ... standing," he said.
All proceeds from the Vaughn Taylor EZGO Invitational Tournament at Jones Creek will be going to Green2Green. The tournament starts Monday.


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Amerec 9111-106 Brushed Nickel Interior Digital Control with Built-In Temperature Sensor
Offer Ends
We still have product details, accessories, replacement parts and reviews below, scroll down to see them!
Interior Digital Control with Built-In Temperature Sensor
Amerec provides a choice of compact digital controls that are compatible with AK and 3K series generators. These attractive controls feature metal cover plates available in five finishes to complement other fixtures in the bath and shower: Polished Chrome, Polished Brass, Polished Nickel, Brushed Nickel and Oil Rubbed Bronze. Each kit includes a steam head and cables necessary to connect the control with the generator.
- KT60 3-button digital control with on/off, temperature and time duration setting
- Display alternates between ambient room temperature and time remaining
- Features integral temperature sensor and must be mounted inside steam room
- Control kit includes KT60 control, cable and Comfort Flo steam head
Additional Amerec Links
Our SKU: KT60
This product is listed under the following manufacturer number(s):
- Brushed Nickel*
- Oil Rubbed Bronze*
- Polished Brass*
- Polished Chrome*
- Polished Nickel*
*Denotes a finish or option that has been discontinued


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Islander Fans,
First off Happy 21st Birthday to Verne'qua Taylor (aka NeNe). Have a good one sweetie!
Hope you all had a wonderful holiday season. The New Year is coming up, everyone be safe!
After we got back from SMU I spent the holiday season with Jessica Jammer aka Jam in Houston with her family. I had so much fun and I actually ate tons of food believe it or not! Her aunt was trying to feed us every 30 minutes. Shout out to Aunt G, Aunt Gayle and Grandma. It felt good to be around a family atmosphere while mine is away in Hawaii < family away from family.
We came back to Corpus Christmas night for practice and exchanged our secret Santa gifts. I had Trish Amboree aka Baby Tee. I got her a coin counter, four bags of candy and phase 10 cards. She loved it. Then Jam had me. What a coincidence. She got me make-up and as soon as I pulled it out I didn't want to look at anything else and even though she wasn't my secret Santa, I got her a spa deluxe kit to relax in the tub.
Here's what went down:
Myeisha Myles had Jam
Alisa Roberts (Lis) had Marquesha Anderson-Sparks (Q)
Q had Lis
Brandi Huff had NeNe
NeNe had Brandi
Damequia Montgomery (D) had Taryn Gregory (T)
Trish had D
T had Ashley Darley (Dar)
Dar had Sara
Zoe had Mye
We left on Monday for Indiana. It felt like a long trip but we had about two hours of downtime before practice at 7 p.m. EST. After practice we went to each other's rooms and we were tweeting and talking. Btw follow us on twitter @IslandersWBB
Tuesday we woke up to snow on the ground. I was so excited. I ran outside. I have been away from living in snow for seven years. -___- Once I get back to snow I feel like a kid again. Tehehe
We went to shoot around after breakfast at 11 a.m. and then went back to the hotel for pregame meal. Then we had about four hours to prepare for our game against the Hoosiers.
Game at 7 p.m. EST: we hung with 'em in the first half and cut the lead down to two at one point but let it slip away at the end. But conference is right around the corner and we are starting again at 0-0 at McNeese State on Jan. 7 in Lake Charles, La.
Now we are sitting in the Houston airport awaiting our 11:40 a.m. flight back to Corpus. This is what we do sitting in the airport:
Have a safe and Happy New Year and I'll be back on Jan. 8th. If any of you want to ask me questions you can email firstname.lastname@example.com and I'll answer them in my next blog. Address the subject as Imani Dunn.


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18906 Shepherstown Pike
Join us every Saturday this month at The Pry House Field Hospital Museum at Antietam National Battlefield will host popular music from the Civil War Era. Each Saturday different musicians from around the region will serenade visitors in the exhibit gallery with songs and instrumentals from the 1860s. Staff at the Pry House will talk about the importance of music to soldiers in the field and in hospitals, as well as civilians on the home front. In a time before recorded music, 19th century Americans placed high importance on public performances, intimate singing circles, and individual musical skill. All performers have donated their time and talent to Music Month at the Pry House. Guests are encouraged to talk with the musicians and ask questions.
February 2: Mr. Cory Rosenberg, of Gettysburg, PA, will play the banjo and other period instruments as he sings popular minstrel songs of the Civil War Era.
February 9: Evergreen Shade, a musical duo from central Virginia, will perform a range of period pieces with a theme on Abraham Lincoln in honor of his 203rd birthday.
February 16: Mr. George Wunderlich, Executive Director of the National Museum of Civil War Medicine, and world-renowned scholar and maker of early banjos, will entertain on his favorite instrument.
February 23: Mr. Wes Merchant, of Frederick, MD, will play from his impressive repertoire of popular and traditional selections on the fiddle.


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Search results for 'hematite'
Stone Dice Hematite 14mm Set and Bag$38.95
Out of stockA full set of dice made from Hematite. They look great and roll well nicely on any game surface. This set come complete with 7 stone dice in total and a black dice bag for easy access. These dice are for the serious gamer. Learn More