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William R. "Bill" Byrnes, Jr., 74
Published: Tuesday, November 6, 2012 at 4:30 a.m.
Last Modified: Monday, November 5, 2012 at 5:28 p.m.
GRANITEVILLE, S.C. — Mr. William R. "Bill" Byrnes, Jr., 74, of Graniteville, S.C., beloved husband of Mrs. Elizabeth "Bets" Byrnes, entered into rest suddenly on Friday, Nov. 2, 2012.
Born on Long Island, N.Y., he was a son of the late William R., Sr. and Eleanor Lasser Byrnes. He was a former Construction Manager with the American Bridge Division of US Steel. His beloved Marine Corps was held very near his heart but his family always came first. Bill loved a round of Golf, playing at various courses with his buddy Frank Douglas on Tuesdays. He was a history buff and recently be became very fond of Quantum Physics.
In addition to his beloved wife of 52 years and his parents, family members include his sons, William R. "Rob" Byrnes, (Nancy Quick) Boulder, Colo., Joseph Patrick Byrnes, (Roxann) Plantation, Fla., and Timothy Sean Byrnes, (Dana) Frazier's Bottom, W.V.; siblings, Janet Wieland, Pa., Tom Byrnes, N.Y., Jimmy Byrnes, Texas, Ann Saunders, Calif., and Corrine Kraus, Calif.; grandchildren, Shaun Patrick Byrnes, Joseph Patrick Byrnes, Jr, Kelsey Skye Byrnes, Laura Gabrielle Byrnes, Samantha Elizabeth Byrnes and Natalie Sean Byrnes, a great-grandson, Dylan Scott Byrnes, and his beloved four-legged son, Brody.
In accordance with his wishes, a private Celebration of Life Service will be held with full military honors being accorded by the United States Marine Corps Honor Guard. Bill will be cremated following the service.
In lieu of flowers, the family has asked that memorials be made to the United States Marine Corps Scholarship Fund, 909 N. Washington St., Suite 400, Alexandria, Va. 22314. (email@example.com 703-549-0060.)
To share memories of Bill and leave a message of condolence for the family, please visit http://www.hatcherfuneralhome.com.
Hatcher Funeral Home & Cremation Service, Langley, S.C., is in charge of the arrangements.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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To the Editor:
As Information International Associates (IIa) begins its celebration of 25 years in business, our team's sights turn to the community of Oak Ridge and its role in IIa's success.
While operating at a global level, it's been our corporate home community of Oak Ridge that has served as one of our greatest sources of motivation and inspiration, all by virtue of the caliber of people, companies and organizations here, whom IIa is ever-fortunate to call our neighbors.
Founded in 1988, IIa has grown to include six national and international locations with more than 150 employees.
Throughout this quarter-century, we have helped clients — including a full cadre of U.S. government agencies — navigate and manage their strategic data needs. In an ever-evolving world of technological advancements, IIa pioneers new strategies, methodologies and techniques to keep our clients always one or more steps ahead.
On behalf of IIa, I want to extend our most sincere thanks to the full community of Oak Ridge for providing a home base to our team that has always sparked our imagination and fueled so much of our ability to grow and succeed in service to our clients.
We embrace the promise of a great future in Oak Ridge with continued growth, here in our hometown.
Bonnie C. Carroll
Information International
Location, ST | website.com

subset: commoncrawl


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The long-term success of films isn't always Apr 23 2007
The long-term success of films isn't always determined by how they did at the box office. Traffic made $124 million at the box office in 2000 while Requiem for a Dream made only $3.6 million ($9.50 of which was mine), but Requiem gets rented 33 percent more from Netflix than Traffic. 'It's almost impossible to go onto someone's MySpace page now and not find a reference to [the Coen brothers'] "The Big Lebowski" or [Terry Gilliam's] "Fear and Loathing in Las Vegas"' - two movies that caused barely a ripple in the theaters."


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The Daily Startup: Easton Capital Sees ITherX's Frugality as Model for New Fund's Investments
Top stories in today's VentureWire:
Easton Capital has just closed Easton Special Situations Fund, raising $10 million to $20 million to invest in medical startups that can be as capital efficient as iTherX Pharma. The firm backed iTherX two years ago through a separate vehicle and the startup advanced a hepatitis C drug into mid-stage clinical studies with less than $3 million–a frugality that investor Easton wants companies in its new venture fund to emulate.
Medical device heavyweight Medtronic and another corporation invested as part of a new $10 million financing for MC10, a small startup whose flexible electronics technology opens a range of possibilities–from on-the-skin stickers that can monitor a baby's fever, to balloon catheters that could restore a heartbeat to normal while inside the body, replacing bulky pacemakers. All of MC10′s existing investors participated.
Also in today's VentureWire, Duetto Research has raised another $10 million in funding to apply big data techniques to managing hotel revenues, as the hospitality industry looks for new ways to maximize profits…Thin-film solar panel company Stion laid off some engineers and operations staff, in conjunction with a $25 million fundraising that is part of a larger, still-open round, VentureWire has learned…and Global semiconductor giant Samsung Electronicsid it has acquired venture-backed Nvelo, a storage software startup based in Santa Clara, Calif. Samsung said the acquisition involves all technology and personnel under Nvelo, but further details of the agreement weren't disclosed.
(VentureWire is a daily newsletter with comprehensive analysis of all the investments, deals and personnel moves involving startups and their venture backers. For a two-week trial, visit our homepage, scroll to the bottom and click "try for free.")
Elsewhere around the Web:
The Wall Street Journal's The Accelerators blog asks this week: What will be the 3-5 top trends for startups in 2013, and why?
Contrary to sworn testimony by Instagram CEO Kevin Systrom, the photo-sharing service received an acquisition offer from Twitter prior to Facebook successful bid, the New York Times reports. Twitter offered $525 million in cash and stock, according to people on both sides of the talks. Instagram agreed to be acquired by Facebook in a cash-and-stock deal initially worth $1 billion. The deal closed at $735 million in September after a sharp drop in the price of Facebook's shares.
This holiday season retailers are making Twitter central to their advertising strategies with stores such as Best Buy using the short-message service to promote deals and host Twitter "parties."


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While Lake Tahoe Basin school administrators didn't name Nov. 7 an official holiday, there was still plenty of celebration surrounding the passage of Proposition 30.
"Today is like Christmas. We're doing a dance. The morale - what a turn-around. It's like having an 800 pound gorilla taken off your back," Lake Tahoe Unified School District Superintendent James Tarwater said on Wednesday morning.
California voters narrowly approved Gov. Jerry Brown's tax initiative by 53.3 percent early Wednesday morning, casting 4,142,442 votes in its favor. Roughly 47 percent of voters opposed the measure that raises sales tax, income tax for the wealthy and prevents drastic cuts in the education system.
"It feels good. No one wants the Draconian cuts that would have occurred. It makes me excited to think that people still place education as a priority," Tarwater said.
If the amendment failed, LTUSD could have lost 12 days of school and $1.6 million in state funding while Lake Tahoe Community College would have faced a 7.3 percent course load reduction, said Larry Green, a LTUSD school board member and math teacher at the community college.
LTUSD can now start compiling the 2013-14 calendar and planning on more consistency when it comes to education funding, Tarwater said.
LTCC President Kindred Murillo said she's glad Proposition 30 passed, but there are still other challenges facing California's education system.
"I was very happy, very excited. It takes one of the challenges we have off the table," Murillo said Wednesday.
Murillo said she doesn't anticipate that the college will add courses during the current fiscal year. Rather, LTCC administrators are analyzing the curriculum and preparing for new guidelines that will go into effect next year. At that time, the college might bring back or add programs, she said.
According to California Community Colleges Chancellor Brice Harris, community colleges statewide will receive $210 million in additional funding this year. That money will allow the schools to serve an additional 20,000 students, Harris wrote in a press release.
"The added support will help stabilize our funding in the near term. Although this measure does not return our system to its pre-recession level, it does head the state commitment to our students and colleges in the right direction," Harris wrote.
Though the majority of Californians backed Proposition 30, El Dorado County voters weren't so supportive. About 62 percent of county voters opposed the initiative, while only 37.8 percent approved it. Out of the 71,976 votes cast for the amendment, 44,768 of those said no to the initiative that will raise taxes by $6 billion annually over seven years.
Proposition 38, the competing tax initiative on the Nov. 6 ballot that would have raised income taxes for most Californians and resulted in increased revenues of about $10 billion a year for 12 years, was defeated handily. Approximately 73 percent of voters opposed the measure.


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Nancy Jardine Meister, 85
Published: Wednesday, December 5, 2012 at 4:30 a.m.
Last Modified: Tuesday, December 4, 2012 at 3:38 p.m.
HENDERSONVILLE— Nancy Jardine Meister, 85, of Hendersonville, died November 16, 2012 at her home. Nancy was born on September 2, 1927 in Syracuse, New York to the late James and Carolyn Jardine; she was also preceded in death by her husband, Charles H. Meister.
She was a member of First United Methodist Church, Hendersonville, and the Hendersonville Country Club, a former member of Kenmure Country Club, Onondaga Country Club, and the Century Club of Syracuse, NY. She was a founding member of the League Club in Hendersonville and Asheville; she was also involved with Junior League, Meals on Wheels, and Everson Museum of Art in Syracuse, NY.
She is survived by her three daughters, Carli Meister and her husband, Paul Rollins, of Glenmoore, PA, Kiki Matthews and her husband, Vaughan, of Hendersonville, Bambi Meister Cummins of New York, NY; one grandson, Wilson J. Matthews of Hendersonville; niece, Nancy Van Duyne and her daughter, Katie of Washington D.C.
A memorial service will be held at 1:00PM on Saturday, December 8, 2012 at the First United Methodist Church, Hendersonville with Reverend Dan Martin officiating. A private burial will take place prior to the service.
In lieu of flowers, memorial contributions may be made to the Community Foundation of Henderson County, 401 North Main Street, Suite 301, Hendersonville, NC 28792.
An online register book is available for family and friends by visiting www.thossheperd.com. Thos. Shepherd & Son Funeral Directors and Cremation Memorial Center is in charge of arrangements.
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Police blotter: Boiling Springs man accused of hitting woman in face, knocking out dental bridge
Published: Monday, November 19, 2012 at 3:15 a.m.
Last Modified: Tuesday, November 20, 2012 at 1:36 a.m.
Spartanburg County Sheriff's Office
A Boiling Springs man remains in jail after deputies say he hit a woman in the face and knocked out her dental bridge on Sunday.
Kenneth Brian Strickland, 46, of 1074 Upper Valley Falls Road, was charged with aggravated criminal domestic violence, according to online jail records.
An incident report states that a deputy responded to the home and spoke to Strickland, who appeared to have dried blood on his forehead. Strickland smelled of alcohol and appeared to be drunk, the report said. He told the deputy that he and his girlfriend had an argument.
The woman pulled up to the home, and the deputy noted that she was bleeding heavily from her head, the report states. The woman said she had tried to leave the home earlier because Strickland was "extremely drunk," but Strickland would not let her leave, hitting her in the face and head with a plastic cup, the report states. The woman's front teeth, which were part of a dental bridge, had been knocked out, according to the report.
Strickland remained at the Spartanburg County Detention Facility on Monday on a $25,000 bond.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Axis is the market leader in network video and a driving force behind the shift from analog to digital video surveillance. Axis offers network video solutions for professional installations featuring products and solutions that are based on innovative and open technical platforms. This focus on fully integrated systems has put Axis in the forefront of the new smart building trend with its systems forming part of an overall building solution rather than a standalone network.
Founded in Sweeden in 1984 Axis now has offices in 40 countries with partner companies in almost 180. With some impressive milestones including the production of the world's first IP camera back in 1996 and some of the first DVR's in 1998 Axis has a history of changing the status quo.
For warranty information click here: http://www.axis.com/warranty/
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Somewhere in the hills of Southern California, Conner Henderson is lining up against the best of the west today. The cross-country runner will represent South Tahoe against about 200 of the best high school runners in the Western United States at the Foot Locker Regional Championships. Elite runners from as far South as New Mexico, as far North as Alaska, and as far West as Hawaii will converge on Mount San Antonio College, situated just outside of Los Angeles, for the 5K national qualifier. The top 10 runners from each of the four regional championships will advance to nationals in San Diego on Dec. 8. "It's pretty much the biggest high school cross-country race in the nation. I'm just going to to go in and lay it all out," Henderson said. "Normally, I have a game plan to stick with whoever is in front of me for about a mile in. Then I just go for it." As a two-time defending state champion, Henderson's game plan seems to be effective. He smoked the Nevada state championship course this year with a time of 16:37, 13 seconds faster than second place. He also captured first at regionals (17:04), a good 11 seconds ahead of his closest competition.Henderson's best 5K time, though, is 15:48. It's a time well within the top 100 who will be running today. It's also a time that defines Hendserson as one of the best in the world of high school running. For someone so speedy, Henderson was surprisingly relaxed two days before the big race. The calm attitude is nothing new. The senior seems to be in no particular hurry to speed through life. "In Conner's case his free spirit, his damn the torpedo's mind set, frees him to race more relaxed," Henderson's track coach Dan Wilvers said in an email. "But don't be fooled by his ease, make no mistake there is a ferocious competitor in there, and a very smart runner."The calm is actually a big part of what makes Henderson such a smart runner. It seems more natural rather than practiced, but either way it gives him a huge advantage on the cross-country course. "That calm is rare among runners because of the intense nature of racing and the objective standard that a clock places on a performance," Wilvers said in an email.Henderson got his nerves out of the way last year when he ran in the same regional championship as a junior. He finished 66th out of about 200, and got a taste of the same tough roller coaster of a course he'll be running today.This year, Henderson is shooting for top 50. He's hoping for top 25. It will be his last high school cross-country race before he hits the college track. "We had such a fun group of kids so it's kind of sad it's over, but it brings college a little closer and I'm looking forward to that," Henderson said. Henderson is in the process of applying to colleges all across the Western states, including University of Hawaii. Where ever he eventually ends up, running will be a part of his future. "He should be a big asset to whatever program he lands at next year," Wilvers said.
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December 1, 2012
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Product Description
The Metrokane Wine/Champagne Sealer seals wine air-tight Preserves champagne bubbles Easy-to-grip, smooth-as-velvet finish Fits any size bottle, including wide-mouth
Product's Review
Great Product Review by Jeanne
Was given one of these stoppers as a gift. Used it frequently so I ordered additional ones for our use and as gifts. Easy to seal your wine and store on it's side without leakage. Great product.
(Posted on 7/24/2013)
Great product Review by JGreen
The Metrokane Wine - Champagne Sealer - Stopper definitely keeps wine fresh. I use it with my red wine and it keeps it tasting just as fresh as when I first opened the bottle. (Posted on 1/18/2013)
Functions as advertised...ONLY stopper I would ever use for champaign! Review by Art
This product works exactly as advertised. It is the only truly effective stopper I have found that keeps champaign charged for up yo a week after opening. It is difficult to find in retail stores. (Posted on 11/27/2012)


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Droop Neck – Tank - Navy
Soft, Sophisticated, Luxurious
The Body Bark Droop Neck is luxuriously comfortable and drapes perfectly so that it may be worn alone or layered with a cardigan or jacket. The front has a double layer which makes the drape extra luxurious and soft and provides an elegant look.
Wear this flattering droop neck alone, whether at home, office or out for fun, and others will wonder why you look so sleek and elegant. The answer – It is a Body Bark!


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The Power of Modern Medicine
Week in Review: The Significance of Forward-Looking Progress
12.13.13 | By
Discovering and developing new treatments for the world's most pressing health challenges helps inspire the work of innovators across the biopharmaceutical sector. More importantly, it's our end-goal to ensure that patients around the world can obtain such innovative treatments in a timely manner. The importance of forward progress in each step of the research and development process cannot be stressed enough, and must be a continued priority for every treatment that comes through the pipeline.
We were reminded of the power of modern medicine and the advancement of medical innovation as we celebrated the 26th Anniversary of World AIDS Day earlier this month. An HIV/AIDS diagnosis that was once a death sentence has been transformed into a chronic disease. This week, we highlighted this medical progress, as well as the 394 other medicines in development for infectious diseases, which affect more than two million Americans annually. With the help of vaccines, 10 infectious diseases have been at least 90 percent eradicated in the U.S. We hope to continue to control or eradicate infectious diseases such as Hepatitis C and HIV with effective treatments stemming from research and development, and a constant goal of advancing progress however possible.
In our "Conversations" forum, we focused on medical advancements to help treat Neglected Tropical Diseases (NTDs), asking experts what is being done to get treatments to the more than 1 billion people who are affected by NTDs. With the help of medical innovation, public and private partnerships and the dedication of many volunteers, treatments are being distributed to patients in need worldwide. As we had many diverse responses and unique insights into treating NTDs, we encourage you to take some time and read what these knowledgeable contributors had to say.
As always, we welcome your thoughts and input on topics that impact patients across the globe. Be sure to check in with The Catalyst each week to learn more about the progress our member companies are making and the new treatments that will help patients live longer, healthier and more productive lives.


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As we approach our 30th year celebration in 2013, we will, from time to time, look back at historical moments of the Wood County Genealogical Society. Because the earliest newsletter we have in the archives is Issue #2 published in April 1986, we have been looking for earlier documents and found a copy of a letter (written by the society president in 1983) which sheds some light on our very first months. Here is a part of that letter dated 29 October 1983:
Thank you for your recent inquiry of Wood County Genealogical Society and becoming a charter member. We have only recently formed. In September we had an organizational meeting and in October we had a beginner workshop. We are excited about our plans for the society's growth. Since we will not have a quarterly to begin with, our membership fees are $5.00 per person each year or $7.50 per family each year. Our year begins September 1, 1983.
Included in your membership, our members volunteer their time to check all indexed records including Wood County cemeteries, marriages, and other area records. Other research will be done for $5.00 per hour. Our Quitman Library has the only collection of Wood County Democrat from the late 1800's to the present. Until 1920 all issues of the newspaper for each year are not there. We would love to have you join our society.
Margaret West Franzen
Filed under: Historical Events Tagged: | Franzen, Society History


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Find It
In the Library
The Valley Library
OSU Libraries
Unique @ OSU
Giving to OSU Libraries and Press
Located in the Learning Commons, the CLC has a variety of services to help support your studies. During scheduled hours, you'll find peer tutors and GTAs from the College of Science, and the Writing Center.
While all patrons are welcome to use the CLC, the participating departments listed below have priority use of the space and equipment. If the space is needed by one of the participating departments, you may be asked to relocate.
Schedules are set by the participating departments, not the Valley Library. Hours may change during Dead Week, Finals Week, and between terms. Service usually begins the second week of each term. Please contact the appropriate department for further information.


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STOCKTON - Police released video Wednesday of a suspected robber punching a convenience store clerk before snatching cigarettes, a box of Slim Jims and what appear to be lemons from a display on the counter.
The robber climbs on the counter as he is joined by others in a mad dash for merchandise, the video shows. He grabs other items, gently places one of the lemons back into the box and jumps down off the counter.
The video comes from security camera footage the Stockton Police Department released on its Facebook page from an early Sunday morning robbery. Police also released photographs of the robbers, including one showing the first robber in a dark sweatshirt climbing onto the counter inside the Quick Stop in the 3500 block of West Hammer Lane.
The incident began after the clerk asked for identification from two young men wanting to buy cigarettes, according to police. They left the store but came back a minute later, assaulting the clerk and leaving with cigarettes, according to police. They came back in a group of several male suspects and a woman who appeared to be in her 20s. Four men struck the clerk again, fleeing with more cigarettes and other merchandise, bringing the total loss to about $300 worth of goods, according to police.
The robbers were described as four white males, 18 to 20 years old, with medium builds and wearing dark clothing.
Callers are asked to contact the Investigations Division at (209) 937-8323 or Crime Stoppers at (209) 946-0600. Callers can remain anonymous. Crime Stoppers will pay up to $1,000 for information.
People also can text information to CRIMES (274637) and type the keyword TIPSPD and then their tip, or log on to the Stockton Police Department's Facebook page and click "Submit A Tip."
Location, ST | website.com


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Definition of myasthenia in English:
1A condition causing abnormal weakness of certain muscles.
Example sentences
- Louise suffers from osteoporosis and myasthenia, a muscle weakness which means she needs to sleep for about four hours after every riding lesson.
- Surgical removal of the thymus gland is performed in patients with a thymoma and can also help some other patients, especially those who develop myasthenia before the age of about 45.
- Unlike myasthenia, however, it is associated with improved strength with repeated muscle activity.
1.1 (in full myasthenia gravis /ˈɡravis/) A rare chronic autoimmune disease marked by muscular weakness without atrophy, and caused by a defect in the action of acetylcholine at neuromuscular junctions.
Example sentences
- It has been useful in treating autoimmune diseases such as myasthenia gravis.
- The drug was first approved by the FDA as a treatment for myasthenia gravis, a chronic neuromuscular disease.
- Congenital myasthenia gravis is rare and can be excluded by maternal and neonatal history.
Mid 19th century: modern Latin, from Greek mus 'muscle' + asthenia.
For editors and proofreaders
Syllabification: my·as·the·ni·a
Definition of myasthenia in:
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
= trending


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Larry Leske, pharmacist at GuidePoint Pharmacy in Redwood Falls, estimates there are currently about 10,000 medications available for patients, and GuidePoint Pharmacy keeps about 3,000 of them on hand."We can get any of the rest the next day, since they're delivered by courier Monday through Friday," he said. "Most people don't realize the extreme cost of the inventory we have to keep on hand."If we fill 6,000 prescriptions a month and haven't used a medicine in three months, it's tough to keep that one on the shelves."We have several clients who have prescriptions that cost $10,000 a month."You can't keep that on a shelf for 29 days. We have to order those two or three days in advance."Virtually all of the prescriptions GuidePoint Pharmacy receives are sent straight to the pharmacy's computers now."Handwritten prescriptions are a thing of the past," Leske said. "We're hooked up electronically with every insurance company."The only exception is prescriptions that contain narcotics still need a handwritten signature to be considered legitimate.Most people don't realize there are only three pharmacies in Redwood County, and all three are in Redwood Falls. There's been a pharmacy at 216 South Wash-ington Street in Redwood Falls for decades, with a variety of owners.In 2009, the business became GuidePoint Pharm-acy, one of an independently-owned group with branches in Rochester, Brainerd, Crosby, Winthrop, Worthing-ton and Grand Marais."One of our owners is on the state board of pharmacy, and on staff at the University of Minnesota," said Leske.One benefit of having connections with the U of M is students from the pharmacy school regularly come out to Redwood Falls to assist at flu and diabetes clinics.Currently GuidePoint Pharmacy in Redwood Falls has two full-time pharmacists and one part-timer.In addition, four pharmacy technicians take and fill orders, and a driver makes deliveries as needed.In addition to filling regular prescriptions, GuidePoint Pharmacy provides a number of other services, such as diabetes and cholesterol checks and blood pressure screenings for customers.GuidePoint Pharmacy is also certified for medication therapy management."For patients who are eligible, we review their medications step-by-step and try to answer any questions they have," said Leske. "Medicare and insurance companies see we save them, as well as the pa-tients, a ton of money by do-ing that, as well as helping the patient's quality of life."In addition to prescriptions and over-the-counter medications, patients can find a separate room full of various medical braces, supports and first aid supplies.Being a small-town pharmacist means being on call all the time. If a hospital or nursing home needs a medication at three in the morning, Leske has to fill the prescription and deliver it."As much as possible, we try to treat the whole patient," said Leske. "We're not just dispensing medications, we're dispensing advice. When the patients leave, they should feel better than when they came in."
Comments are currently unavailable on this article
Location, ST | website.com


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This article provides data from performance and robustness studies of the Celsius FFT freeze-thaw system for the long-term frozen storage of biopharmaceutical products. In this study, gamma irradiated containers filled with 6 L of colored water solution, were frozen inside a conventional upright freezer and thawed in different conditions (ambient temperature and water bath thawing). Furthermore, frozen containers were submitted to physical challenge to assess their robustness in routine handling and accidental drops. The physical challenge tests concluded that Celsius FFT 6 L is compatible with routine handling in frozen state.
In addition, the Celsius FFT system is compatible with standard laboratory equipment, facilitating its implementation in existing facilities and eliminating the high capital costs associated with specialized technologies.
Large-scale freezing of liquid in standard laboratory equipment is generally a slow process because of the limiting cooling capacity of the freezing equipment, the low heat transfer coefficient, and the large freezing distance of the container. To circumvent these effects, the Celsius FFT system uses multiple small containers (e.g., 6 L) with a large external surface-to-volume ratio and specific design features to maximize heat transfer.
The objective of this study was to evaluate the freeze-thaw performance of Celsius FFT and to demonstrate if it is well adapted for freezing protein solutions for process development or small-volume manufacturing, when very rapid freezing kinetics is not required.
The S71 film used in the manufacturing of the bag chamber is a multi-layer, co-extruded, high gas barrier film, containing EVA copolymer as fluid contact layer and ethylene vinyl alcohol polymer as gas barrier layer. The film has been extensively characterized for liquid and frozen storage of biopharmaceuticals.
For this study, a Celsius FFT 6 L bag was modified with the addition of a spike port. A T-type thermocouple was introduced in the bag through the septum of the spike port. The thermocouple tip was located 18 cm from the tubing port in the bag center line. Additional thermocouples were placed on the top and bottom faces of the container, between the shell and the bag's external surface. A last thermocouple was used to monitor the temperature of the environment (freezer chamber or water bath). Temperature monitoring was performed with an Almeno 5990-2 (Ahlborn) data acquisition system.
Freezing experiments were performed inside a –86 °C ULT Forma, (621 L) upright freezer (Thermo Scientific) with a –70 °C temperature set point. Two Celsius FFT containers were frozen for each experiment. Thawing experiments were performed in a 20 °C water bath without agitation or at room temperature with exposure to ambient air.
The robustness of the Celsius FFT 6 L under routine operating freeze-thaw conditions and accidental drops was assessed with the following physical challenges.


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Palmetto crash kills pickup driver
Published: Thursday, March 7, 2013 at 10:18 a.m.
Last Modified: Thursday, March 7, 2013 at 10:18 a.m.
A driver was killed Wednesday morning after the truck he was driving ran off the road and caught fire, authorities said.
The victim has not been identified yet, according to the Palmetto Police Department.
The accident occurred just before 11 a.m., as the victim was driving a 2006 Chevrolet pickup north on 10th Avenue West, approaching Seventh Street West, police reports noted.
Witnesses told investigators that just before the truck reached the intersection, it left the roadway, jumped the curb and continued north through the park. The truck struck a sign and two trees, then crossed the intersection, striking another sign and a third tree.
The final impact stopped the truck, which then caught fire.
The driver, the lone occupant of the truck, died at the scene.
The Palmetto Police Department is investigating the crash.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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OAKLAND -- Presuming the Warriors make the playoffs, you know that they hope the current seeding doesn't stick.
If they did, that would pair the Warriors against Memphis. And after the Grizzlies manhandled the Warriors on Wednesday night, 94-87, that matchup doesn't look good for Golden State.
"They're an experienced team, a veteran team," Warriors point guard Stephen Curry said. "They've had many experiences in the playoffs, grinding out games. They have pretty much the same unit back that they've had the last two or three years. You have to play a smart, efficient 48 minutes to beat them, either at home or on the road. They know how to play together."
It was Golden State's eighth consecutive loss to Memphis, which used its size and physicality to wear down the Warriors. Coming off the embarrassing loss to the host Los Angeles Clippers, having three days to stew, boasting a 9-1 record after a loss, you'd figure Golden State would come out ready to make a statement.
But the Warriors ran into a brick wall. Led by forward Zach Randolph and center Marc Gasol, who combined for 31 points and 21 rebounds, Memphis was just too much inside. The Grizzles had 60 points in the paint, the most the Warriors have given up all season.
"They have possibly the best front line in the NBA," Warriors forward David Lee said after totaling 14 points on 14 shots with 10 rebounds. "They have depth on the front line, and athletic wings to go a long with it. ... That's the strength of their team, grinding in the paint and offensive rebounding. I thought we fought hard."
The Warriors also didn't knock down enough shots. They were 46.5 percent from the field, including 7 of 17 from 3-point range. But thanks largely to turnovers (15) and the grinding pace of the game, Golden State took 17 fewer shots than Memphis. Usually, the Warriors get more shots than their opponent.
Curry sat at his locker shaking his head at the disparity in attempts.
"If they shoot 17 extra shots," said Curry, who had a team-high 24 points, "with the team that they have, it's going to be tough to beat them."
Golden State (22-12) lost consecutive games for the first time since early November. But for a moment, it looked as if the Warriors had a chance to pull it out late.
After trailing by as much as 14 points in the first half, the Warriors trailed by five midway through the fourth quarter. A 3-pointer by Curry and two free throws by Klay Thompson tied the game at 82 with 3:32 left.
But Memphis answered by going inside, and Gasol muscled in a layup. Moments later, a turnover by Thompson led to two free throws by the Grizzlies' Mike Conley Jr.
The next time down, the Warriors' Jarrett Jack had his pull-up jumper blocked, which turned into a layup by Conley. Golden State was down six inside of two minutes left.
After a timeout, Lee converted a jumper. But Rudy Gay answered with one of his own.
A 3-pointer by Curry cut the deficit to 90-87 with 40 seconds left. But the Grizzlies went right to Randolph, who drew a foul and knocked down the free throws.
The Warriors had no answer for the interior dominance of Memphis (23-10). The Grizzlies grabbed seven offensive rebounds and outscored the Warriors 20-4 in the paint in the fourth quarter.
"We battled, and we made some tough plays," Warriors coach Mark Jackson said. "I thought we did not seal off our possessions defensively. Down the stretch, they got some offensive rebounds that really hurt us. ... They execute you to death and playing them will force you to get better."
Yahoo! Sports reported Tuesday that Memphis and Phoenix are engaged in trade talks and that the Grizzlies are shopping Gay.
Sources confirmed the Warriors received a call from Memphis, but the discussion about the small forward didn't progress because Memphis -- looking to cut salary, get young talent and draft picks -- had no interest in taking the Warriors' Richard Jefferson, one league source said. And Golden State doesn't have any draft picks to give.
But the improbability of the trade didn't stamp out the intrigue. Not even for Gay.
"Hey, anything can happen," Gay said about the prospect of playing for Golden State, smiling as he headed to warm-ups Wednesday at Oracle Arena.
For any such trade to happen, it stands to reason Jefferson or Andris Biedrins to be involved. The Warriors are not going to take on a big contract without giving up one of those two. And Gay certainly qualifies as a big contract. He's due $16.4 million this year and $37.1 million more over the next two seasons.
"There are going to be rumors because that's the nature of the business," Jackson said. "I don't address it. We are a team. We are together. We have a purpose. We are not going to get caught up with anything that is not our goal."
Gay boasts a rare ability the Warriors could definitely use. He's an exceptional athlete who is a load in transition.
It may not be enough for the Warriors to pull the trigger on Gay. But it certainly sounds like his days in Memphis are numbered.
"There are very few players who play on one team for their whole career," Grizzlies coach Lionel Hollins said. "You just do what you do with that team for as long as you're there."
Friday's game
Portland (19-15) at Warriors (22-12), 7:30 p.m. CSNBA


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Dear friends !
I am about to buy a new road bike (Scott CR1 Pro, Scott Addict R3 or Scott CR1 Elite) and I wonder which of the following sets are better:
Thanks for your opinions
As a bicycle mechanic of over 20 years and an amateur racer of about the same length of time I would recommend that you base your decision primarily upon which shift/brake lever fits your hand better. Shimano, SRAM, and Campagnolo all produce very nice systems that work well (when properly adjusted) and last a long time. The weight difference between comparable groupsets can be nullified with a few light weight component substitutions.
I agree with Dougolas on the fit angle. They do vary and while they are all better than older models, well, in general anyway, they are different. But you need also to consider ergonomics and performance. I happen to think, for example, that my front shifter/derailleur combo for my 8 speed Dura-ace set up performs better than my 10 speed Dura-ace and 10 speed Ultegra (that I have on my cross bike.) I think that the SRAMS, which I have test ridden numerous times is close to the Shimano and the shifting pattern with the levers is somewhat intuitive coming from Shimano but I could see how someone might not like it or prefer it over Shimano. What I can't get used to, even on extensive test rides, is the shifting mechanism on Campy. My pals who use it love it but while I think the comfort zone when riding the hoods is nearly spot on, the hand action required to press the thumb lever to be way out of wack. It requires an awkward movement, at least for me, pulling my hand back and off the hood to push down that lever. This is terrible ergonomicall speaking and consider I might want to do that action in the middle of a descent. I don't like the idea of minimizing my hand contact interface.
Some shop guys may try to sell you on the fact that one product is better due to the enhanced capacity to replace parts but I would say that fit and performance should outweigh that value as SRAM or SHIMANO or Campy are all well made products and last a long time. As far as value, weight and performance, the RIVAL might be a great way to go but for me, I'm sticking with Shimano for now. Also, for some of you, consider that if you have Shimano casettes and wheel hubs now, they will generally be compatible with SRAM and vice versa (but not Campy.)
Go to a shop and ask to test ride two bikes back to back with both shifters. Then ride it making sure you come out of the saddle shifting up and down and up and down hills too.
*Go Real Fast!
Have been a Shimano faithful for 25 years, 80,000 miles.
Mostly Ultegra, and one one ... upgrading to DuraAce through the years.
Switched to SRAM Rival last year on a new Cannondale SuperSix, and LOVE IT. 2,500 miles later LOVE IT. THe double-tap shifting has never mised, and works well. THE BEST THING is that the shifters pivot so on a screaming downhill I can firmly grip the drops while also holding the shifters, and then up shirt as needed without ever loosening my killer grip. LOVE IT
I ride Shimano on my road bike and SRAM on my mountain bike. My preference is based primarily on the comfort with the STI shifters than performance. The SRAM set up on the MTB seems more crisp but that is irrelevant to my roadbike performance. Still the Shimano set up (105/Ultegra)has not let me down either.
Gotta Ride Today
aka Chuck Faulkner
Tazewell, TN 37987
I am not a racer so I wasn't looking for the 'best performing' cassette and derailleur. So like the other respondents I went for the best 'fit' - my personal preference for how the shifters and brakes work and feel in my hands. I really like the SRAM Double Tap shifters. Single lever for upshifts and downshifts and a separate brake lever. I prefer this setup over the Shimano single lever for upshifts and the combination brake / downshift lever. As for Campy my hands didn't feel comfortable on their hoods.
Whatever you choose I am sure you will enjoy your rides.
I have until recently, only used Shimano but after try SRAM on a road bike, I think that I prefer the SRAM. I've never really liked Campy. I wasn't sure about SRAM reliability but from what I hear, it's good.
That's my two cents.
Joepucci wrote:
I wasn't sure about SRAM reliability but from what I hear, it's good.
Based on my MTB experience I don't have any issues with the reliability of SRAM components. I run the X-9 group on my bike and X-7 on my son's. In all cases everything installed nice and it is a snap to tune up. I have never tried double tap shifting on even a demo bike so just have no idea what to expect. I'm in a groove with STI and hesitant to change. Getting ready to build a full carbon bike and planning to go Ultegra just to keep everything similar on both bikes. Folks that ride SRAM seem to really like it though.
Gotta Ride Today
aka Chuck Faulkner
Tazewell, TN 37987
Well, there have been some thoughtful insights offered so far. Perhaps we should ask Lance. I'm not positive but I believe he was the first winner of the TDF to use Shimano and may have been the first on the podium with SRAM.
Often around here we will say, "if it is good enough for Lance it is good enough for me!"
Its a personal thing. I tried different groupos and I prefer SRAM.
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Of course Greg but what about SRAM appeals to you? I like their ads for example but would use those to get me to try the product. Ergonomics, cost, replacement warrentees? You have a shop owners orientation. What say you? Keeping warm?
It is about 8F here. Just finished a ride, albeit a tad shorter than usual!
I think it's best to see what feels right to you.
For what it's worth, I enthusiastically bought a Shinamo group for my bike a few years ago and was very disappointed with the build quality as far as durability. My brother who had a Shimano group at the same time had the same issues. It seemed like something broke every time he went out on it. I wasn't a Campy fanatic at the time, but bought Campy tp replace it, and I can say I'll never go back. You can't beat Campy for quality and durability. My Centaur/chorus mixed group works flawlessly and has been bullitproof.
Now, so many people (including pros) use Shimano, so it can't be bad, but my experience (and my brother as well) was negative. BTW, my buddy just got a new bike, replacing his old one with 22 year old Campy stuff that worked as flwlessly as the day he bought it. Seriously, I'm not one of those old "campy-only" guys, that has just been my experience.
I have no experience with SRAM, but I'd really like to try their stuff.
Wow. I've been in and around a lot of riders and shops over the past couple of decades and I've not heard of intrinsic problems with Shimano and in fact the reliabilty has always been considered excellent. About the only issue I've heard of is getting the front derailleur to work when a chain ring set up was swapped to Compact drive. Sometimes the shifting is dependent upon the construction of the frame or the dimensions as it is oriented to the rings and spacing. A mechanic can certainly explain this better than I. The two examples cited above are unique to my experience. What were the problems specifically?
With my groupo, within 2 years the headset races became pitted such that when the handlebars were turned, they kind of locked in to a certain position; the cassette cogs wore down within 8 months so I had to replace them. And I'm really anal about keeping my bike clean, adjusted correctly and lubed, so both of these were a shock to me. My replacement grouppo (non-Shimano) was 14 years old when I replaced it and everything worked as well as the day it was new.
On my brother's bike with Shimano, a bottom bracket spindle broke, front deraileur broke and he had a few other parts that wore prematurely.
Like I said, so many pros and sport riders use Shimano that I'm sure it's good stuff; I hope our experiences were not common. That was just my experience. And when I'm paying for things with my hard-earned cash (unlike the pros), I want what will be reliable. To me, that means Campy.
That siad, when it was new, it sure worked nice.
That's a bummer. I don't know how much the set up orientation for the head set would come into play for that to wear out. I'm still on my original on my Felt F1C which is going on six years now and about 18 to 20,000 miles I'd say. My Merlin still is all original with the 8 speed Dura-ace gruppo and the only replacement there was my rear derailleur after probably 15,000 miles or more and that was only because there was a slight delay between the third and fourth cog and my buddy had a spare to give me (he's a nice guy and a great frame painter!) and that bike runs great. As I mentioned I even prefer the front derailleur feel of the 8 over the 10 speed (first edition) components.
I have had great success with my cogs. All Dura-ace. My Felt came with an 11-23 (another discussion I've written about on other threads here on Active) and while I do use other configurations for racing or hill climbing I've probably gone over 15, maybe 17,000 miles on that cassette. While I clean my bike dilegently and that as you know should play a role, I would not have expected a cassette to last this long. My chain rings, 53-42 (another discussion made elsewhere on Active) are the orginal rings as well. Still smooth.
Sorry you had some bad luck I think and your sibling too.
As mentioned, I can't get over the ergonomics of the campy shifters but that is why there are options!
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Trey Anastasio Band,
Friday, 06/09/2006
Verizon Wireless Amphitheatre - Charlotte, Charlotte, NC
Set 1: Sand, Drifting, Cayman Review, Sleep Again, A Case of Ice and Snow, Shine > Mr. Completely, Mud City, Dragonfly, Tuesday
Notes: This single set performance was as the opening act for Tom Petty & The Heartbreakers. This setlist is unconfirmed as recordings of the performance do not circulate.
Musicians: Trey Anastasio, Russell Remington, Jennifer Hartswick, Raymond Weber, Ray Paczkowski, Christina Durfee, Tony Hall, Ben Groppe


text: Top 11 Products Of 2011 From Endurance LIVE By Triathlete.comPublished Jan 22, 2011 << Back to StoryOpen full size in new window. The 2011 Felt DA Liz Hichens is the Web Editor of Triathlete.com. She is an Ironman and marathon finisher and fan of all endurance sports.Follow @lizhichensFollow on Google+All articles by Liz


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NHBR: Once downtrodden, Claremont is on the upswing
A drive through downtown Claremont three years ago was a sad experience. Architecturally, the downtown is a stunner, but if you were to head down any street at the time, you'd see more empty storefronts than occupied ones.
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