text:
Charmed (1998–2006)
Episode List
Season 5
22 Sep. 2002A Witch's Tail: Part 1
Mylie, a mermaid, is prepared to sacrifice her immortality to the sea hag, an evil witch who must deliver eternal life to the skeleton demon Necron, in order to share life with her human lover Craig Wilson, a hunky businessman, and needs him to explicitly express his true love for her, which seems utterly pointless fussing to him, so Mylie turns to hearts column writer Phoebe, who is resuming her career, like Paige who even gets a promotion to social worker. Phoebe had thoroughly prepared her divorce on account of Cole's disappearance, but at the very moment the judge...
22 Sep. 2002A Witch's Tail: Part 2
Paige, Leo and Piper try to track the mermaid Phoebe, who is eventually captured by the demon who made the deal with the sea-hag for immortality. Meanwhile, Piper is worried about fighting while she is pregnant.
29 Sep. 2002Happily Ever After
An Evil Witch kills the keeper of the Fairy Tales and forces the sisters to relive them: Phoebe is controlled by Cinderella's glass slippers, Paige bites into Snow White's poisoned apple and Piper and Grams fall prey to a wolf.
6 Oct. 2002Siren Song
Cole and Phoebe are lured to their death by a Siren, while after an argument Piper and Leo have their powers switched by their unborn child so that each can walk a mile in each other's shoes.
13 Oct. 2002Witches in Tights
The Charmed Ones are turned into superheroes by a student who can bring his drawings to life.
20 Oct. 2002The Eyes Have It
The blind demon Orin and his son Cree kill Shuvani -Rumanian gypsies- and steal their eyes in the hope to make Orin see again and get the evil eye. Phoebe gets on to it trough gypsy fortune teller Madame Theresa, who got a vision meant for her but tells only Lydia, who warns her niece Ava Nicolae, a surgeon, who turned her back on gypsy magic after her mother's death: the demonic murder means they're all targets. Paige is still frustrated without a job, Piper still impossible to live with because of her abnormal pregnancy. Phoebe's next vision at Teresa's funeral ...
3 Nov. 2002Sympathy for the Demon
Barbas, the Demon of Fear, returns stealing Cole's powers and again battles the Charmed Ones using their darkest fears against them.
10 Nov. 2002A Witch in Time
By continually saving the life of her boyfriend Phoebe opens up a portal from the future allowing a warlock to pass into the present on a mission from future Cole.
17 Nov. 2002Sam I Am
Paige is given her first charge as a white lighter, her real father Sam.
5 Jan. 2003Y Tu Mummy También
When a demon kidnaps Phoebe to provide a body for the spirit of his dead lover, Cole tries to save her by trading Paige for Phoebe.
12 Jan. 2003The Importance of Being Phoebe
Cole uses nonmagical legal means to manipulate the sisters in giving him ownership of the manor and access to the Nexus. Paige is arrested, P3 fails a health inspection and Phoebe is replaced by a shape-shifter.
19 Jan. 2003Centennial Charmed
After realizing that he will never get Phoebe back in this reality and getting tired of her sisters' constant attempts at vanquishing him, Cole agrees to become an avatar. The first thing he does with his new powers is throw himself into an alternate reality where he is once again Belthazor and Phoebe and Piper never met Paige, meaning the Power of Three was never reconstituted. Paige herself is thrown into the opposite reality also when a sneeze makes her orb during Cole's spell. While Cole attempts to live his life happily with Phoebe as his bride, Paige tries to ...
2 Feb. 2003House Call
After the sisters have some remnant evil spirits removed from Halliwell Manor, the witch doctor puts an obsession curse on the sisters. Paige is determined not to allow her friend Glen to marry, Piper become obsessed with cleaning and Phoebe begins a vendetta against a rival chauvinistic newspaper columnist.
9 Feb. 2003Sand Francisco Dreamin'
After a demon kills the sandman and uses his sleep dust to cause the Charmed Ones' nightmares to come to life, the sisters must each face their own nightmares asleep and alone. Piper is imaging a dream lover, Phoebe is being chased by a maniac with a chainsaw and Paige is being tormented by clown from her own childhood.
16 Feb. 2003The Day the Magic Died
The sorcerer Cronyn has waited for the rare natural phenomenon aurora borealis and other signs spelling a prophesied cancellation of all magical powers, good and evil, to set in motion a devious plan to eliminate the Charmed Sisters and especially Piper's baby, which is now about to be born premature. Meanwhile grandpa-to-be Victor presents his bride from a dating cruise, nurse Doris, who insists on assisting Piper, whose doctor ordered strict bed-rest, so it's mainly Leo's task to prevent her finding out as long as possible. Cronyn convinces Phoebe and Paige to ...
30 Mar. 2003Baby's First Demon
A Crone is plotting with other demons to steal Wyatt and his power, but Wyatt demonstrates that he can protect himself. Paige disguises herself as a bounty hunter to track down her nephew's enemies.
6 Apr. 2003Lucky Charmed
Leprechauns are being killed by a demon who then steals their magic. They help the Charmed Ones fight the demon by granting them good luck, but things do not work out as planned.
13 Apr. 2003Cat House
While visiting a marriage counselor, Piper casts a spell to allow Leo and her to literally see their past together. The spell drags Phoebe and Paige back in time to relive Piper's memories along with a warlock that wants to kill their cat Kit who has returned to Halliwell Manor.
20 Apr. 2003Nymphs Just Wanna Have Fun
The Charmed Ones help two nymphs rid themselves of a demon who was after the pond they guarded. The remaining two nymphs decide that Paige would make an excellent replacement and turn her into a nymph.
27 Apr. 2003Sense and Sense Ability
While the sisters, Leo, and Wyatt are enjoying a family trip to a carnival, the Crone plots to steal the senses of most use to the Charmed Ones - Piper's sight, Phoebe's hearing, and Paige's voice - and use them to help her kidnap Baby Wyatt.
4 May 2003Necromancing the Stone
The matriarchs of the Halliwell line are summoned for the Wicanning of Wyatt Matthew Halliwell but the Necromancer demon is trying to absorb their magical powers.
11 May 2003Oh My Goddess!: Part 1
The sisters are visited by a white lighter from the future: Chris Perry, who informs them that a new threat, the Titans, have been awakened. The Titans who are looking for white lighters come after Paige and Leo discovers their plan.
11 May 2003Oh My Goddess!: Part 2
Chris tries to convince the sisters to come up with a plan to vanquish the titans but they feel discouraged without Leo who, Piper realizes, is becoming an elder.


text:
Filter by:
Content type:
Stage 1&2
Stage 2&3
Stage 3&4
Stage 4&5
Challenge level:
A counter is placed in the bottom right hand corner of a grid. You
toss a coin and move the star according to the following rules: ...
What is the probability that you end up in the top left-hand. . . .
Use this animation to experiment with lotteries. Choose how many
balls to match, how many are in the carousel, and how many draws to
make at once.
Four cards are shuffled and placed into two piles of two. Starting with the first pile of cards - turn a card over...
You win if all your cards end up in the trays before you run out of cards in. . . .
This interactivity invites you to make conjectures and explore
probabilities of outcomes related to two independent events.
Can you beat Piggy in this simple dice game? Can you figure out
Piggy's strategy, and is there a better one?
A simple spinner that is equally likely to land on Red or Black. Useful if tossing a coin, dropping it, and rummaging about on the floor have lost their appeal. Needs a modern browser; if IE then at. . . .
Is this a fair game? How many ways are there of creating a fair
game by adding odd and even numbers?
Start with any number of counters in any number of piles. 2 players
take it in turns to remove any number of counters from a single
pile. The winner is the player to take the last counter.
The opposite vertices of a square have coordinates (a,b) and (c,d). What are the coordinates of the other vertices?
7 balls are shaken in a container. You win if the two blue balls
touch. What is the probability of winning?
Six balls of various colours are randomly shaken into a trianglular
arrangement. What is the probability of having at least one red in
the corner?
Identical discs are flipped in the air. You win if all of the faces
show the same colour. Can you calculate the probability of winning
with n discs?
Can you find all the 4-ball shuffles?
The aim of the game is to slide the green square from the top right
hand corner to the bottom left hand corner in the least number of
To avoid losing think of another very well known game where the
patterns of play are similar.
Show that for any triangle it is always possible to construct 3
touching circles with centres at the vertices. Is it possible to
construct touching circles centred at the vertices of any polygon?
Discover a handy way to describe reorderings and solve our anagram
in the process.
Can you work out which spinners were used to generate the frequency charts?
Can you put the 25 coloured tiles into the 5 x 5 square so that no column, no row and no diagonal line have tiles of the same colour in them?
Do you know how to find the area of a triangle? You can count the
squares. What happens if we turn the triangle on end? Press the
button and see. Try counting the number of units in the triangle
now. . . .
Slide the pieces to move Khun Phaen past all the guards into the position on the right from which he can escape to freedom.
A game for 2 players. Can be played online. One player has 1 red
counter, the other has 4 blue. The red counter needs to reach the
other side, and the blue needs to trap the red.
A game for 2 players that can be played online. Players take it in turns to select a word from the 9 words given. The aim is to select all the occurrences of the same letter.
Use Excel to explore multiplication of fractions.
Given the nets of 4 cubes with the faces coloured in 4 colours, build a tower so that on each vertical wall no colour is repeated, that is all 4 colours appear.
in how many ways can you place the numbers 1, 2, 3 … 9 in the
nine regions of the Olympic Emblem (5 overlapping circles) so that
the amount in each ring is the same?
Can you give the coordinates of the vertices of the fifth point in
the patterm on this 3D grid?
On the 3D grid a strange (and deadly) animal is lurking. Using the tracking system can you locate this creature as quickly as possible?
Can you make a right-angled triangle on this peg-board by joining
up three points round the edge?
A and B are two interlocking cogwheels having p teeth and q teeth respectively. One tooth on B is painted red. Find the values of p and q for which the red tooth on B contacts every gap on the. . . .
These formulae are often quoted, but rarely proved. In this article, we derive the formulae for the volumes of a square-based pyramid and a cone, using relatively simple mathematical concepts.
Charlie likes tablecloths that use as many colours as possible, but insists that his tablecloths have some symmetry. Can you work out how many colours he needs for different tablecloth designs?
A right-angled isosceles triangle is rotated about the centre point
of a square. What can you say about the area of the part of the
square covered by the triangle as it rotates?
Can you spot the similarities between this game and other games you know? The aim is to choose 3 numbers that total 15.
You can move the 4 pieces of the jigsaw and fit them into both
outlines. Explain what has happened to the missing one unit of
If you continue the pattern, can you predict what each of the following areas will be? Try to explain your prediction.
We can show that (x + 1)² = x² + 2x + 1 by considering
the area of an (x + 1) by (x + 1) square. Show in a similar way
that (x + 2)² = x² + 4x + 4
This resource contains interactive problems to support work on
number sequences at Key Stage 4.
Practise your skills of proportional reasoning with this interactive haemocytometer.
An animation that helps you understand the game of Nim.
How good are you at finding the formula for a number pattern ?
Meg and Mo need to hang their marbles so that they balance. Use the
interactivity to experiment and find out what they need to do.
Here is a chance to play a fractions version of the classic
Countdown Game.
A collection of our favourite pictorial problems, one for each day
of Advent.
Square It game for an adult and child. Can you come up with a way of always winning this game?
The classic vector racing game brought to a screen near you.
This game challenges you to locate hidden triangles in The White
Box by firing rays and observing where the rays exit the Box.
A tool for generating random integers.
Can you set the logic gates so that the number of bulbs which are on is the same as the number of switches which are on?
A metal puzzle which led to some mathematical questions.

subset: commoncrawl


text:
Outlander (Abridged / Compact Disc, Abridged)
Claire Randall is leading a double life. She has a husband in one century, and a lover in another...
In 1945, Claire Randall, a former combat nurse, is back from the war and reunited with her husband on a second honeymoon—when she innocently touches a boulder in one of the ancient stone circles that dot the British Isles. Suddenly she is a Sassenach—an "outlander"—in a Scotland torn by war and raiding border clans in the year of our Lord...1743.
Hurled back in time by forces she cannot understand, Claire's destiny in soon inextricably intertwined with Clan MacKenzie and the forbidden Castle Leoch. She is catapulted without warning into the intrigues of lairds and spies that may threaten her life ...and shatter her heart. For here, James Fraser, a gallant young Scots warrior, shows her a passion so fierce and a love so absolute that Claire becomes a woman torn between fidelity and desire...and between two vastly different men in two irreconcilable lives.
About the Author
Diana Gabaldon holds a master's degree in marine biology and a Ph.D. in ecology, and spent a dozen years as a university professor before turning to write fiction full-time. Her previous publishing history includes scholarly articles and comic book stories for Walt Disney, as well as the award-winning novels Outlander, Dragonfly in Amber, and Voyager. She lives in Scottsdale, Arizona, with her husband, three children, and a large number of animals.
From the Paperback edition.
Praise For…
"Absorbing and heartwarming...lavishly evokes the land and lore of Scotland."—Publishers Weekly
"Stunning!"—Los Angeles Daily News
"It is a large canvas that Gabaldon paints, filled with strong passions and derring-do. Strong willed and sensual, Claire is an engaging modern heroine plopped down in a simpler, more primitive time.... Great fun ...marvelous and fantastic adventures, romance, sex ...perfect escape reading!"—San Francisco Chronicle
From the Paperback edition.


text:
A little over six months after its release, The Crew is getting its first large expansion pack entitled "The Crew: Wild Run." The reveal trailer for The Crew: Wild Run showed …Continue reading →
The Crew is being billed by its developers as a revolutionary action-driving game that will take advantage of the more powerful current-gen consoles. Races will take place across various locations …Continue reading →
The Crew now has an official launch date, Novmber 11th. On top of that, there will be a closed beta launching on the PC come September 23rd. During the Ubisoft …Continue reading →
There were some questions about whether or not The Crew was a 2014 title, but now we have confirmation, a shiny new trailer, and some sweet new screenshots to confirm …Continue reading →
Just saw this bit of news over at the Microsoft official Xbox newswire - apparently Dead Rising 3, Just Dance 14 and Project Spark will have native support for …Continue reading →
The Crew has looked fairly interesting since its unveiling at this past E3 and Ubisoft has continued to intrigue me by releasing some more screenshots and a new trailer. The …Continue reading →
They sure do! Not just these kids, either: the series has proven wildly popular with younger gamers, producing great sales numbers and repeat accolades from the Kids Choice and Teen …Continue reading →
The worst gaming drought of my life struck in the summer of 1995. I'm sure someone remembers that as the year their all-time favorite Super Nintendo or Atari Jaguar game …Continue reading →


text:
23 December 2011
A Very Merry Christmas Giveaway!!
The last 2 weeks I enjoyed crocheting hats, I've had so much creating and they are going to be a good Christmas present for some family and friends.
Here is the picture of the hats:
Also, I want to give you the chance to win one of them and also other crafty goodies, like the new January/February 2012 Paper Crafts Magazine (I have a Birthday tag there!), a brand new Stampin' Up set and a stamp and ink pad from Studio G. I may add some ribbon and other things.
What to do? Just a leave a comment here, telling me what would you like to see next year on my blog, what you like or don't like, or just say Hi!!
I will be back on December 28th and announce the winner that day.
Hope you all have a Very Merry Christmas or if you don't celebrate it, have a nice fun time with your family and friends!
God bless.
24 comments:
Wonderful! You are so talented and I love the hats! Thanks for the chance!ReplyDelete
Hello!! :) I love all of your crafty ideas and hiwjperfect your projects turn out!ReplyDelete
First of all a very blessed Christmas to you and your family, i consider it a blessing to have "met" you this year. I love your cards and they are always inspirational. Your posts are very informative and I like the instructions and lists. God bless.ReplyDelete
Woo hoo, thanks for the chance to win one of these! I love your blog, don't change a thing!ReplyDelete
Those hats are gorgeous!! My youngest son would like one of those!! Thank you for a chance to win!! Wishing you and your family a very merry christmas!!! HugsxxReplyDelete
May God, who sends His most precious gift to us, His Son, shine on you and your family during this most blessed time of year.ReplyDelete
Your blog has truly inspired me; it brings my 'creative
juices' flowing every time I visit. Those hats are just so adorable; my little 5 month old granddaughter would look so precious in one.
Lovely hats, Giovana! Merry Christmas to you and your family!ReplyDelete
Those hats are awesomeReplyDelete
Thank you on this giveaway opportunity.
Wishing you a Very Merry Christmas and a Happy and Healthy New Years.
Cute hats. I crocheted at least a dozen hats last year to be used for Chemo Caps. Love your blog. You are such an incredible artist. Just love looking at your cards. Merry Christmas.ReplyDelete
Your work is lovely. I look forward to your blog for great inspiration. Thanks so much for all you do for us in cyber space that love crafts. Merry Christmas to you and your family.ReplyDelete
Love the hats! I can't believe your range of talent. I am like others here, I love your blog just as it is, and look forward to it every day. Wishing you a very Merry Christmas!ReplyDelete
Wow what a nice job with those hats! Thanks for sharing your talents and for a chance to win. Merry Christmas!ReplyDelete
Your hats are so cute. I've always wanted to learn to crochet.ReplyDelete
Merry Christmas!
Stopping by to say hi, love the hat's. thanks for a chance to winReplyDelete
I love the inspiriation on your blog. I find the instructions helpful as I am learning many new things. Thank you for the chance to win and may the Christ of Christmas fill your life this coming year.ReplyDelete
Hi Everyone!! Hope you are all having a good week!! I have been busy getting my "Card Calendar" done for the new year of 2012. WOW, where did 2011 go!?!!?!My "Card Calendar"...I so lovingly have named is a calendar that I have right next to my craft desk. It helps me remember all those special days that I make my handmade cards for. I buy the biggest calendar I can find so I have plenty of writing space. So every December I go through a new calendar and make notations such as anniversaries,birthdays etc. How does everyone else remember their special days? Thanks so much Giovana for giving us cardmakers a ton of ideas by showing your examples. I have used more than one this year. Those hats are so beautiful. My dear mother-in-law who passed away 3 years ago taught me how to crochet. She could whip up a baby blanket in an afternoon!! Have a good year all!! Sandra ♥ReplyDelete
Merry, Merry Christmas to you and yours, Giovana! Thank you for sharing your beautiful creations with us - keep on doing what you're doing! Thank you for the chance to win! All the best in 2012!ReplyDelete
These Hats are adorable! Great job on making them Giovana! Merry Christmas to you and your family! God Bless You all!ReplyDelete
Love your hats!!!ReplyDelete
Specially the black one :)
If I win one, YAAAAY!!!
If I don't, oh well
Well I wouldn't change anything about your blog! :) Love and am inspired by all you do and appreciate all you share!!! Thank you and hope you are able to enjoy this special season (and it's reason) with your family!!! :)ReplyDelete
Hugs Crystal
Wow, Giavana those are some fabulous hats ! I like them ALOT!ReplyDelete
Those are fabulous hats, your blog is great as it is (keep up the good work) You are definitely a woman of many talents. Thank youReplyDelete
your hats are ADORABLE! great job my friend! don't include me in the giveaway though! just wanted to say you are doing great!ReplyDelete
The Childhood memories these hats evoked....I remember as a young girl wearing hats just like these, my mother would every winter crochet a new hat to coordinate with the clothes that she would lovingly sew for us, it was magical to see her transform a piece of cloth and wool into something so loved. thanks for tickling out those cherished moments!ReplyDelete


text:
Illustrated companion
The setting is Cookham Churchyard with the River Thames in the background. Christ, with children in his arms, appears enthroned in the church doorway in the centre of the painting, with God the Father leaning over the back of the throne. Along the wall of the church is a row of prophets including Moses, with a dark beard, holding the tablets of the Ten Commandments. The rest of the churchyard is filled with people resurrecting from their tombs. The group of black people emerging from sun-baked soil implies that Spencer's conception embraces the whole of humanity. Spencer made it clear that his Resurrection was a joyous event and that the resurrected are already in Heaven: '... in the main they resurrect to such a state of joy that they are content ... to remain where they are.' Even 'the punishment of the Bad', said Spencer, 'was to be no more than that their coming out of the graves was not so easy as in the case of the Good'.
'The Resurrection, Cookham' was painted at a turning point in Spencer's life, as it was started about a year before his marriage, in February 1925, to the painter Hilda Carline; the painting contains strong autobiographical elements, whose precise significance remains a mystery. The central nude figure supporting himself on two gravestones is Spencer himself, as is the clothed figure lying on the brick tombs in the lower right corner. The kneeling nude figure is his new brother-in-law the painter Richard Carline. Hilda Carline appears at least three times: most notably, she is the half-hidden figure in a striped dress in the ivy covered tomb in the centre foreground, surrounded by a spiked fence. She is thus contained in a protective bower but is directly linked by the line of her body, and by proximity, to her brother and husband.
Spencer returned to the Resurrection theme in 1947-50 when he painted 'The Resurrection: Port Glasgow', also in the Tate Gallery [N05961].
Published in:
Simon Wilson, Tate Gallery: An Illustrated Companion, Tate Gallery, London, revised edition 1991, p.137


text:
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Skin Horse by Shaenon K. Garrity and Jeffrey C. Wells
- July 02, 2012
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UNITY our favorite assembled from the dead super weapon.
Really glad to see some of my favorite comix-folkers, although Nera's cuter than a bug.
I am glad to see Unity again. She's my favorite. :)
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just finished the welcome slide for the freshly relaunched version of http://jeffclickhomes.com/
* i would prefer to never use the word "awesomeness," but i kinda fits here so IDGAF
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I'm no profesional photographer. I just like to share pics of my beautiful island, Puerto Rico, and of other places I have had the privilege to visit. I am fascinated with this website cause there are so many great pictures that give me the chance to see other amazing places of the World.
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Thursday December 23, 2004
Cayey, Puerto Rico
Caption: The Coqui belongs to a family of tree frogs that consists of 16 different native species, 11 of those are endemic species, THEY ONLY OCCUR IN PUERTO RICO! Here in the Island we love to listen to the Coqui sing at bedtime, and its melody is dearly missed by the Puerto Ricans that are away from home. The name "Coqui" comes from the song that the male sings, what is seems to say is: "Ko-kee ... Ko-kee".
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text:
Next you measure out all of the oils. This recipe called for shea butter, olive oil, and lard.
See how my pot almost covers the scale? That's what made things hard. The nice thing was the little zero button that allows you to measure one ingredient, zero the scale, and then continue measuring and adding other ingredients all in that one pot.
My friend suggested that we add the solids before the liquids. It's important to measure the ingredients exactly. Soapmaking is a very delicate chemical process.
Put these oils on the stove at a low heat to melt. Stir as needed. Keep an eye on the temperature once it's all melted.
Now it's time for the excitement. Make sure that you're wearing your safety goggles & gloves and have some ventilation where you're working.
Gently pour the lye into your pitcher of water. It heats up to 200* immediately and stinks. Stay clear of the fumes. Stirring heats the water and you will need to get the temperature down per your recipe so avoid stirring.
You really need to have two thermometers. One for the lye mixture and another for the oils. You can perhaps wipe them clean as you go back and forth, but it's a lot to keep an eye on. You're trying to get both mixtures at the same temperature: cooling the lye mixture and heating up the oils. Tricky stuff.
But oh, sweet mercy, when the temperatures are in sync, you get to pour the lye mixture into the oils and that's when the magic starts to happen. Your heart will race and you'll find yourself thinking, "I'm doing it. I'm really making soap!"
I was so excited, I couldn't even take a good picture.
Now you get to add the yummy fragrance oils. Mix gently and carefully with the stick blender paying close attention to the consistency. You're waiting for it to get to the elusive "trace" that soapers talk about. Trace is when it's kind of like pudding and when you dribble the soap across the pot, it leaves a faint line.
If you close one eye and squint your eyes, you might be able to see what I'm talking about in this pic. Don't hold your breath though.
I was thinking about making soap, not taking pictures.
Once it's at that perfect consistency, you can pour it into the molds. You can just use regular boxes lined with wax paper or store-bought molds.
See how ours isn't perfectly smooth? That's how you can tell it is homemade. Ha ha!
Maybe we let it get too thick.
Can any of you soapers let me know?
This recipe has to cure for 3 weeks. I can't wait to see how it turns out.
It smells sooooo good.


text:
Capitol Hill Critics Second-Guess Agencies Using...
Loss of Lives in Clinical Trials...
Keep the Opportunities, Lose the Opportunists
From our August issue: Clinical-Style Validation,...
Scientists in recent years have grown impatient with the conventional model of macrophage activation. According to this model, macrophages—the scavenger cells that engulf and cellular debris and pathogens—are divided into two groups: "classical macrophages," which spur on inflammatory processes, and "alternative macrophages" which shut down inflammation. And yet macrophages, in respond to environmental cues, are capable of altering their physiology, giving rise to different populations of cells with distinct functions. Functionally, macrophages even seem to display mixed types, as though their activation pathways were as varied as the colors of an artist's palette.
Still, the old model prevailed. It proved too useful to alter, especially since new information about macrophage activation was emerging slowly and seemed more suggestive than definitive. Phenotypic analysis, for example, did little to induce change. And even microarray-based gene expression profiling fell short, despite linking macrophage plasticity to changes in transcriptional regulation. With this technique, it was possible to collect evidence of transcriptional reprogramming, but it was still a challenge to sort through the molecular mechanisms that might be at work.
Undeterred, researchers began studying macrophage activation more systematically. In particular, a group of researchers at the University of Bonn recently expressed an interest in undertaking an integrative analysis of epigenomic and transcriptomic data to better understand how macrophages respond to environmental cues. The researchers' ultimate goal was to identify specific transcription factor combinations responsible for cellular macrophage programs.
Considerable progress toward this goal was reported February 13 in Immunity, in a paper entitled "Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation." The paper's authors include scientists from the University of Bonn, as well as colleagues from the University of Massachusetts and the University of Edinburgh. In their paper, they go so far as to propose a "refined, activation-independent core signature for human and murine macrophages."
According to these researchers, macrophages are capable of processing diverse stimuli, which activate specific transcriptional programs. Further, these programs drive macrophages to fates more varied than the two in the traditional macrophage activation model. In fact, macrophages may assume at least nine different forms which use their weapons to optimally fight intruders in different ways.
To uncover these results, the researchers stimulated human macrophages with diverse activation signals, acquiring a data set of 299 macrophage transcriptomes. Analyzing this data, the researchers determined that NFKB1, JUNB, and CREB1 are central transcription factors of macrophage activation. In addition, they found that TNF, PGE2, and P3C activates a STAT4-associated transcriptional program.
Essentially, they identified central transcriptional regulators associated with all macrophage activation complemented by regulators related to stimulus-specific programs. "With complex bioinformatic analyses, we obtained a type of fingerprint for each macrophage which showed us which genes in the cell were directly active," said Prof. Dr. med. Joachim L. Schultze from the Life & Medical Sciences (LIMES) Institute of the University of Bonn. Using this genetic fingerprint, the scientists were able to deduce which combination of stimuli led to the macrophage developing in a particular direction.
Applying their newfound knowledge, the researchers examined how transcriptional processes differ between alveolar macrophages from smokers and those from patients with chronic obstructive pulmonary disease (COPD). Curiously, the researchers found a loss of inflammatory signatures in COPD patients.
Prof. Schultze said, "We have to step away from the simple classification of macrophages and investigate them more closely in respective connections with diseases." Once scientists "depart from the conventional pattern, fully new concepts [will] open up."
"This is the dawn of new therapy options," added Prof. Schultze, noting that macrophages play a role in many widespread diseases such as arteriosclerosis, obesity, diabetes, asthma, Alzheimer's disease, and cancer.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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General Chat
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|13 Sep 2004 03:50
Hi Everyone,as you will see from the time not sleeping well tonight ,have a very rumbly tum,don't know whwt has caused it ,John has eaten the same and is snoring away in our room.I have been up and taken a hot drink and also some indegestion mixture.I don't have any pain just a very noisy and rumbly tum.Good job i am not working tomorrow. June I did ask my son about the pubs and he gave me a couple og suggestions,One I know,Yates's is on Portland Street a bit nearer to Piccadilly, the other I think is off Aytoun Street whic I think is a bit far away.I wouls also like to go and see what they are like before I make a suggestion. Hope you are feeling better.Like they photos from the liverpool meeting on Colins site. How are things with Lady/Sadie Jude ? Hi Christine,have seen dolls like you have mention very life like. Hopefully I will be back tomorrow ,after I get some sleep.Hope evryone else is ok ,they must be having busy weekends. Take care ,Brenda
|13 Sep 2004 11:09
Hi everyone, We have another sunny morning but the last day or two has started sunny then turned to rain late afternoon. Its still rather windy too. Brenda, I hope your tum is better now, maybe John has a cast iron tum! The only pub I know of is the Wellington near the Cathedral and once when I went to Chinatown we had a drink in the Britannia? I will have to leave you to have a pub crawl on which is best.lol I haven't seen the photos on Colin's site I haven't managed to get on it yet. Christine, You are right about the walks, I still have the memories and some interesting moments, some good and some quite frightening. I was wondering why no one had posted, but of course the site has been down for more than 24 hours, so we couldn't. This time, I will be back tomorrow. Love June xx
|13 Sep 2004 11:46
Morning all:o) Sorry l did'nt get to tell you all about me weekend before now, the site was down and its been abit busy here. l did leave a message on ancestryaid, got chucked off Colin's site,in fact pooter crashed!!:o( Anyway the dog is here - she is an absolute poppet, BUT the cat situation is not good. When we picked her up there was a cat in the office,when she saw it, she was very interested but nothng nasty - On first meeting with Fat cat he did what l expected him to do, hiss and grow double in size, dog was ok,still very interested - then they met on stairs and he clonked on the nose - so ever since then she is worrying where he is,rushing upstairs etc and goes down on all fours,then stalks towards him. l am waiting for the kennels to phone to guide us with next steps - we have introduced every so often, she goes very rigid and still - so we will see what happens from here. Last night she was as good as gold, no noise,no mess, perfect - she loves everyone and everything,so lets hope she really loves Fat Cat (Jimmy really) The weather at present is fine,but nasty clouds are on the way!! Spoke too soon,its now raining and Vic has got the washing in:o) June we like walking but not that much!!! Once we have the dog sorted we will start our river walks again, or atleast hubby will!!!! Quite likely going to stick with the name Lady, we have tried Sadie and we both automatically call her Lady - she actually responds to a whistle more than anything!! she's at my feet now:o)) The furniture is lovely - not megga expensive,the store bought in a load of Next diningroom tables/chairs and console tables,cause Next did'nt want to put them in their catalogue or something. Brenda - hope your feeling better now,nothing worse than a rumbly tumbly!!!:o(( Christine - yeh that doll does sound scary, especially the idea of it being almost real, what next!!!?? l can remember the dolls that cried and how we all thought how real they seemed!! Hope everyone is well and speak later, hopefully l will have heard from the kennels. Jude sarf wales
|13 Sep 2004 18:21
Hi everybody, Yes, it's me, I'm back from my holiday in England. What lovely weather we had. I arrived home yesterday, worn out, but happy! It was so nice to be with my daughter and her partner; we had many laughs. We giggle like teenagers at the most stupid things! Her partner, Henk, doesn't speak, or understand, very much English, and couldn't understand what we were amused at half the time. We enjoyed eating fish and chips again, but how that has gone up in price. For us over here Gt Britain is terribly expensive. We went to the Wedgwood factory and I bought one or two pieces of china. We went to Bourton on the Water, Burford, Oxford, Witney (where my daughter was born). We went to a motor museum. Janet and Henk went to London on Wednesday and we old ones had a day of rest. All the walking around and not being used to it makes us tired. Coming home we visited the large shopping centre in Calais, where we again spent some money. I bought all the things which I cannot buy here. For instance, Options. I've tried all sorts of chocolate drinks, but none can beat Options. At one time I could buy it here, but not anymore. I have finished most of my washing, but now the ironing - ugh! I went out to the shops again today, but this time on my scooter. My toe is still very painful. I phoned the doctor this morning at 10.15 and was told I could come at 11.00, but as I was not then dressed, I said no I'll never make that. I'm not usually so late in moving in the morning, but I couldn't get going today. This afternoon she had special cases to see and tomorrow was her day off, so I've made an appointment to see her on Wednesday. Well everybody, have a nice evening. Sylvia xxx
Member Since:
|14 Sep 2004 03:06
Welcome back Sylvia, and hi to everyone, Sylvia you made the 100 on here, pleased you enjoyed your holiday. The weather has changed a bit now and is getting colder so you chose the right time. Sorry your toe is so painful, hope the doctor can do something to help. You are right fish and chips is more of a treat these days, it has become so expensive. I have been reading in the Practical Family History about the lacemakers. Brought back memories of visiting my Aunt who lived in my grandmothers house after Nana died. I used to go to stay occasionally and my cousin would take me to visit two old ladies who lived in the road behind my g.mothers house. This was in the 1940's and they were still making lace in the old way. I loved to watch how swiftly they moved the various threads to create the most beautiful lace, there would be about 20 or so threads and some of the patterns were so intricate. Better still they had a large wooden chest which I loved to be allowed to look through. It was full of tablecloths, chair backs, table runners, collars and cuffs (for dresses), and the most beautiful Christening shawl - so fine it was like a cobweb. Whenever I visited they always had their "pillows" at the side with some work in progress. It was fascinating and something I would love to be able to do. I often wonder what happened to all that lovely lace, these ladies were sisters and neither had children. I do hope it went somewhere where it would be appreciated. Jude, I have been following the story of Lady, perhaps she was meant for you seeing that she already had that name. Fat Cat will probably take a little time to accept the 'interloper' but I'm sure he will eventually. My cats were very quick to put Kyzer in his place when he joined us. Fortunately he was a quick learner, though a little puzzled over their reluctance to play with him. He was only a tiny puppy then and they had been with us for 7 years by then. Eventually they would curl up and sleep around him, but were still quick to give him a quick "clip round the ear" if he stepped out of line. We had the cats for 19 years and Kyzer for almost 15. No more though - I couldn't face the heartache again. June, when I lived in Frenchwood I used to walk over the bridge (the next one down from Bamber Bridge) where the railway ran - I suppose it still does. I would walk for miles either back towards Bamber on the other side of the river or through the little wood on the far side of the bridge. Used to be full of cowslips, primroses and bluebells - often got lost and would find myself having to walk through some farmers field to find the road and find my way back to Pemwortham to walk back along by the river on our side. Would be gone for hours - what a pity kids can't do that sort of thing today. No doubt it has all changed now anyway. We used to pick tons of blackberries from the side of the railway tracks, forbidden to cross the tracks of course, but the best blackberries were on the other side, so of course we did cross over. We would be very dirty, hot and covered in blackberry juice when we got home. All that of course was when I was very young!! Brenda, did they ever get that carpet dry? I think you have said you don't always work in the same library, how many do you cover? Hope you are still enjoying the job. Have noticed that you have not been sleeping too well some nights Elisabeth and everyone else, hope you are all keeping well, sorry I haven't mentioned all by name - my memory is suffering a bit. Had some trouble getting the computer to co-operate tonight, it was refusing to boot properly so it took me ages to get connected. Goodnight to you all, have a good day and hope the sun shines wherever you are. Kathleen
Member Since:
|14 Sep 2004 08:38
Thought it was about time I added to this new thread........ Hi Elisabeth, Brenda, Ann, Jude, Kathleen, Dilys, June, Lou, Christine and Syliva. Apologies if I missed anyone but that covers the last page or so. I haven't been up to much recently. I took up golfing in May and go a few times a week but have yet to attempt 18 holes. Playing 9 holes for 2-3 hours is quite enough! Unlike Peter who sees kangaroos and emus I just see deer, rabbits and big ol' bull frogs. I've donated quite a few balls to the bull frog's pond so far! My b-i-l's been going through a messy divorce this last year but has had some good news now. The child psychologist/custody evaluator recommended he gets custody of the children if his ex-wife leaves the state so it's a big relief that he will be able to see his children when he wants. At least he didn't have to dress up in a Batman costume and climb up on the White House! We've spent a lot of time helping him move and get settled in new rental apartments. Does anyone remember Tears for Fears? A local radio station and Starbucks were hosting a free concert downtown on Saturday and we were privileged to witness their first gig since they split in the early '90s. They were very good and haven't changed a bit. They are supposed to be touring the UK in a few months. That's all for now, Crista
|14 Sep 2004 09:08
Hi everyone, Its a very wet blustery day here, doesn't look like the washing will get hung out today, last night I actually put the heating on for a couple of hours. Dilys, Nice to hear from you, your wedding sounded fantastic. Kathleen, I remember my mother crocheting collars and cuffs and pillow case edgings etc., I have no idea where they all went, I didn't see them when I cleared the house. Yes the railway is still there, but there has been a lot of building work, as there as all over the country. I think the footpaths are still there, because they are signposted both in Penwortham and Bamber Bridge saying Preston. I just wish I was fit enough to explore, then again these days I wouldn't like to go on my own. Sylvia, I'm sorry your toe isn't better yet, thankgoodness it doesn't seem to have spoilt your holiday, you seem to have done a lot of exploring and reminiscing. Yes I agree fish and chips have certainly gone upmarket now, its no longer a cheap meal. Carol from Rochester,New York State was over a few weeks ago and she said she found it expensive over here too. I suppose it has just crept up on us, though I do keep moaning that the food bills are climbing all the time. Jude, I do hope Fat Cat and Lady settle their differences, I'm sure they will eventually. Lady will probably come back from her walks by the river and lie down, and Fat Cat will see she isn't really a threat. Hope everyone else is alright, see you tomorrow, Love June xx
|14 Sep 2004 19:59
Hi all, I still can't get myself moving at the moment, I feel like I'm still on holiday. The aches and pains are getting less though. My dear neighbour came down this afternoon and said that she had nothing to do, and ............wait for it..............."could she do my ironing for me". What do you think I said, .......... yes, you're right. She was born in Germany and irons so beautifully. Johan's trousers now have a nice crease in them, instead of a mass of creases - 3 pairs of trousers plus shirts all neatly ironed and also 3 pairs of trousers of mine and blouses. What a gift. She has no hobbies, so when her housework is finished she doesn't know what to do do. She goes to bed at 8.00 pm! I have so many hobbies, and cannot seem to get to bed before, at the earliest 1.00 am. The weather here is very windy, but I like this. We have thunder and lightning this evening. I don't like weather which is still, it's just not me! Tomorrow is my doctor's appointment, so will let you know tomorrow what she is going to do with my toe - maybe only 4 toes by tomorrow evening! Have a nice evening all, Sylvia xxx
|14 Sep 2004 22:10
Hello Everyone,I was tired out yesterday from shopping ,ironing and doing an extra shift at the library that I could not bring myself to even turn the computer on ,never mind read and write a message.I have not felt like that for ages.It was 8pm when I left the libraray (i started at 5pm)and it was dark ,it felt really late,maybe thats why i felt so tired? I had another 8pm finsh tonight ,I started at 12.30pm ,but did not do much at home before I went ,so wasn't too bad when i got home. It has taken me ages to read all your smashing messages,and I will try ro remember what you have all said. June I will do the reccy for the pub when I am back from my holidays. Jude hope Lady/Sadie continues to settle and fat cat sees she is not a threat to him. Slyvia,glad you had a nice time,hope the toe is ok. Crista,John has played golf for a few years now and thinks I should get out of the house more and take it up as well.!Kathleen,no I'm sorry to say the carpets are not dried ,everytime it rains they get wtter,they smell awful now,some of the borrowers have been making complaints now,and I do not blame them. I cover 5 libraries all within a few miles from home,one I can even walk to,It only takes 15mins at most to get to the farthest one,and it's all free parking so I am not out of pocket there. I do have afew nights when I don't sleep ,but it is not as bad as last year. Sorry if I have forgotten anyone,speak to you tomorrow,take care ,Brenda
|14 Sep 2004 23:02
Yes, yes, yes, yes at last (l know its only 2 days) they have settled their differences and met face to face offfff the lead!!!!!!!!!!! l had got to the stage where Lady was not responding to food and banging the table or a tray to get attention did'nt even get a flinch (on a lead)when her and Fat Cat were in consoltation so to speak!!!!! l had just put the phone down after speaking to an animal behaviouralist and forgot the cat was on the mat!!!! (in the hall),opened the lounge door and left it open - oh my word a god almight hiss and scuffle and now everything is as good as OK. l rang her because of the way Lady was reacting - down on belly and stalking, very rigid and not interested in treats at all!!!!!! the Fat Cat has now put her in her place and everytime she goes towards Fat Cat l whistle and she comes back - blimey!!:o) not taking all this for granted though. As you can imagine l am now alot more relaxed, lwas really worried - l know everyone said they will settled their differences etc, but seeing them was'nt so easy to believe it! It has rained on and off here as well, very mixed! AND I HAVE been to work - Community Project today, 9.30am to 1pm, which means walking in the Forest,cutting shrub back,doing garden projects etc and most importantly getting the students to think,care and be responsible - they were absolute gems today. Not the group l had last term where one cheeky monkey liked grabbing manaquins bits!!!!!! which is a real shame, but hey!! Off tomorrow and working allday Thursday and Friday - yippeeeeeeeee Sylvia - sounds like you had a great time and to get someone to do all your ironing what a bonus!!!!?? take care of that toe. Brenda - take it easy,how many days do you work and what do you do at the library?? Crista,Kathleen l will answer ur messages in the morning - dog is ready for bed,hubby has gone to bed,so spose l ought to follow. Nite nite all:o) Take care everyone,hope l did'nt forget anyone:o( Jude sarf wales
Member Since:
|15 Sep 2004 02:32
Hi everyone, Looks like there are a few new ones on board. I haven't been doing any genealogy, I've been trying to get fit again. Went into the city last night and ran a 5k race. It was fun seeing so many old faces from quite a while ago. I got into genealogy when my mother-in-law had a stroke and came to live with us so my running took a back seat as I was much more restricted in my movements. It's taken quite a long time to get my enthusiasm back again but I'm hoping I'm on the come-back trail. Crista, Can only imagine how fit people must get playing golf. I have no eye-ball co-ordination so that is a limiting factor for me for quite a few sports.
|15 Sep 2004 10:45
Hi everyone Its lovely and sunny here, although we did have a short shower earlier. Christine, you do very well to do a 5k race, keep it up as long as you can, we all need something to enjoy and what better way? Jude, I'm glad Lady and Fat Cat have a truce, I dare say they will have the odd spat, like children they will have a quarrel then forget all about it. I like the sound of the work you do, lovely walking in forests looking at plants etc. Most students are good but you always get the odd one showing off. Brenda, you seem to be very busy with this job but as long as you enjoy it , that is the main thing. The reccy on the pubs will be fine after your holidays, its very good of you to look round for us. Sylvia, I hope your toe is soon sorted out, our feet are very precious to us. You have a lovely neighbour to come and do your ironing for you, thats one of my pet hates and whenever possible, I buy clothes thst do not need ironing. Later I have to go and get Gaynor's prescription, they hadn't got them in yesterday, then one of my friends is coming round. She has just come back from Detroit, she surprised her brother on his birthday, so she has lots to tell me. Hope everyone else is alright. See you tomorrow Love June xx
|15 Sep 2004 17:48
Hi Everyone,well I am now offically on holiday,yippee,and have some ironing and all my packing to do tonight and tomorrow. Jude I,m glad Fat cat and Lady are repecting each other,our old cat loved our old dog ,but would not go near our present dog.Yet when the cat died the dog was so lost. Christine,I am what is known as a libraries and information assistant.I do 18 hours per week over a six day week.I usually do one late ,starting at either 12.30 or 4 till 8pm,one early starting at 9am till 1or 5pm.and and Saturday 9am-5pm.But the other days can be any, last week I was off Monday , workedTuesday4-8pm off Wednesday ,off Thursday.Friday and Saturday worked 9am -5pm. I have found that when I do a late I shouldn't go out doing any shopping or having lunch before hand,as I get so tired I find the job interesting.I issue books to borrowers delete loans when books etc are returned.take the money for overdue items,Find books that people have requested,see if the libraries stock certain books etc. File the books back.keep the shelves straight.Help book computers .photocopiers etc. I am really enjoying it,it is a lot less stress than my other job.Mind you the public can be very funny at times. But allin all it's good. I have been told my tea is ready ,John has just dished up.so I will have to go,Sorry if I didn't get round to you all ,might be back later when ironing done HAHA. take care Brenda
|15 Sep 2004 18:23
Hi everybody, Woke up to a showery, windy day, but I don't mind at all. Visited my doctor. I thought my appointment was 3.40 but it was 2.40, but my kind doctor fitted me inbetween. I have to go to the hospital for an x-ray to see how the bone is. My doctor will cut a piece of the nail away herself she said. It is still very painful, but I've had worse things than this. I'm busy making my Xmas cards now. I have made 35 - but need somewhere in the region of 80. Every Xmas card I make is different! I love being creative. I worked until I was 63, so enjoy all the time I can spare making and doing things. My neighbour, the one who did all my ironing for me, came down with 2 rainbow trout. They were caught in Denmark and frozen. I now have to work out how to clean and cook them. I got round to making my bread again yesterday - so much nicer than shop bread! I'm not spending so much time now on the boards as there are so many more things to do. See you all again, keep this thread going. Love, Sylvia xxx
|15 Sep 2004 21:09
Hello everyone This is going to be quick, it takes so long to post messages tonite its driving me mad. Not in the best frame of mind either - the dog, cat situation not too good today, Fat Cat has been chased out of the garden now and next doors cat, don't mind that too much cause he keeps catching the Blue Tits - grrrrrrrrr. Fat Cat has just been in for food but shot back out the back door - can only hope they settle down cause its getting me down now. l know its only been a few days, but its distressing to see. l wonder if she was a farm dog before, she's never settled always following us around and curls up on the concrete tiles in kitchen - at night she gets in her bed though,thats where she is now. Anyway we'll see. Nite nite Sorry if l have'nt actually chatted to you and gone on about me, need me bed now:o( work tomorrow, new class,new students!!!!! :o)) Jude sarf wales
|16 Sep 2004 10:38
Hello Evryone,should really be finshing my ironing now but had to check emails and here I am. Jude,don't worry about not chatting to everyone,it's about telling us whats happening with you as well. I find I do it a lot when something gets me down or makes me feel good. Really hope the cat/dog situation does get better for you,like I said before our old cat and present dog did not get on at first ,then settled into a sort of stand off respect thing and did not bother with each other ,but we did have one or two skirmishes,sorry about spelling. Slyvia,two of my friends have been making their own cards as well ,they enjoy it tremendously and sometime make special orders for friends families etc. Glad the doctor could see you ,don't think ours would.Hope the toe is sorted soon.Must go now,it's my little brothers birthday (well both my brothers are younger than me actually but this one is smaller than me as well)and I have to get his cards round to him.Hope to get back on here later when the packing is done.But if I don't I will be thinking about you all.look after yourselves and take care ,see you Oct 2nd. Brenda
|16 Sep 2004 10:58
Hi everyone Its very blustery here today and definitely chillier although it is dry. Brenda, I hope you finished your ironing in time, have a good time, you have been working hard you deserve it. Jude, It must be very worrying and I'm sure they will settle down in time, in the mean time its you that is getting stressed out. Dont worry about the messages being short, we love to hear that you are alright, though I must admit I enjoy your colourful accounts of events. Sylvia, Your neighbour is an absolute gem, dont let her escape! First she does the ironing and now trout! I hope the toe is soon better, at least the doctor is interested which is more than be said about some. You are getting me interested in making cards, my daughter does this, I really must find the time. This afternoon my friend will be coming, we both enjoy painting ceramic ornaments and tracing our family history, so we are never short of something to talk about. Hi to everyone else, I hope you are still reading even though you aren't posting at the moment. Love June xx
Member Since:
|16 Sep 2004 17:03
Hello everyone Has been fine and sunny today though a bit breezy, just right to get the towels dry. Well it would be if I had remembered to hang them out!! Went shopping whilst they washed and then forgot all about them - oh well......... Nothing very exciting to tell you all about, bit fed up with my son's not getting on with some of the jobs they have said they will do. Hence the kitchen is still not getting it's ceiling plastered, nor the doors painted, so no chance of getting any new flooring down yet. Have to put up with the old, paint splattered tiles for a bit longer. Jude, give them a bit more time, it's still early days yet and I'm sure they will settle down together before too much longer. Brenda, I hope you have a fabulous holiday - come back feeling nicely relaxed. Won't stay any longer just now - I am fed up and think I will go out for a walk to buck my ideas up. Love to everyone - will be back later, hopefully feeling more cheerful. Kathleen ps. Have just seen No.1 son getting the sander out - looks like the doors just might get prepared for painting.
|16 Sep 2004 18:26
Well not much has been happening here today. My granddaughter, bless her cotton socks, came after school and cleaned my bathroom and toilet and did the vacuuming. What did I do, well I changed the beds, washed the bedding and almost finished ironing it. Oh yes, I baked bread again. My husband has been walking around like a zombie all day with headphones on listening to a debate on television on how our ministers have misspent a lot of our money. The sun has been shining, and the outlook is good for tomorrow for my weekly trip to the market with my neighbour. At least I'm keeping the thread going with my little chat. Bye now, Sylvia xxx
|16 Sep 2004 20:48
Hi everyone - another very quick message. Lady go's back to the kennels in the morning - the situation with her and Fat Cat is not getting any beter, we keep trying to have them together and doing the treat thing when she looks away etc , but she does'nt react to much - banging on the table,tray etc often does'nt work,calling her name sometimes works. Fat cat has spent the past 2 days in the garage, sleeping in doors at night and eating when he's relaxed (not often). She is the sweetest thngs,but really not a cuddly pet.l can't decribe it - my nephew is here tonight and can see what l mean. Don't know when we can look again cause the kennels suggest we wait till she has been re-homed - if she see's us around the kennels or we see her,it won't be fair. So, l am about to dish up dinns, speak to you tomorrow:o((( Jude sarf wales


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Harrison is architect of "the future", says Gardner
Not a future, but the future. Following news late last night that Phil Harrison is to join Infogrames as president, CEO David Gardner has got all excited about the new Atari.
"In terms of European leaders in the games development industry, I've always wanted to work with Phil," he said. "He's going to partner with me to build the future. He'll be the most senior guy responsible for all the content and network-centric material, all the investments that we make in games."
In effect, then, Phil Harrison is the future. We knew there was something about him.
Sometimes we include links to online retail stores. If you click on one and make a purchase we may receive a small commission. For more information, go here.


text:
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Copyright © 2016 Figure 8 Maternity. All Rights Reserved.


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Want Your Home to Make the Best Impression? Think Paint.
One of the quickest, most economical and effective ways to improve the appearance and marketability of your home is painting. Kelloggs Painting, www.kelloggspainting.com, explains how painting your home makes it look clean, bright, and inviting, and gives you the biggest bang for your fix-up buck.
"It can't be overstated—when it comes to buying a house, the first impression is everything. If you're selling or getting ready to sell in the coming months, one of the easiest and most dramatic ways to enhance that first impression is through paint.
"Curb appeal is crucial," said Mary Sheridan, an agent in Silver Spring, Md. "Buyers get a lot of information from the web now and I find that often they have already driven around with a list of addresses and have decided which ones they want to see, giving curb appeal a lot of weight."
If nothing else, paint at least the door, door frame, and foyer or first room the would-be buyers will see.
Paint railings, window frames, trim, and other accents to freshen up the exterior.
Homeowners and buyers place a high value on the painted appearance of a home. Include the date the paint job was completed and the quality of paint that was used.
You can easily paint wood, brick, masonry, aluminum or vinyl siding.
And if you don't to paint the whole house, consider an eye-popper like the front door.
"It is very important to have a home looking its best and that starts as soon as a buyer drives up to the home," said Paul Thury, a Connecticut Realtor. "One important tip is to paint the front door if you cannot paint the whole house. This brings a good feeling as you enter the house."
Another important tip is to get all your painting done before potential buyers view the house.
"It is important to have all the repairs and paint done before going on the market," said Julie Nelson, a real estate consultant in Austin, Texas. "You need that bam experience on day one on the market. Anything less than bam and you're just helping the other homes in the neighborhood sell first."


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updated 03/26/2014 AT 5:30 PM ET
•originally published 03/26/2014 AT 5:40 PM ET
"She was dying," recalls her mom, Nancy Day, 66. "There was nothing we could do to reach her."
Nothing, that is, until a stray kitten wandered into her family s backyard in Fenton, Mich., and Ransley fed it a piece of hot dog. She decided to adopt the tiny animal. A few days later, she took it to a local veterinarian and received a bit of news that transformed her life.
Her new pet, it turns out, wasn't a kitten – it was a severely malnourished adult cat. "I didn't see the irony at the time," recalls Ransley, who quickly threw herself into nursing Riley back to health – and eventually began to get a better grip on her own health, with continued treatment.
Today, Ransley, 27, works as a therapist, helping those who are battling eating disorders. "Riley," she says, "was the catalyst for me getting better."
For more stories of the life-changing power of pets, pick up this week's PEOPLE magazine.
With reporting by SHARON COTLIAR


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Rams off to a perfect season start; heading to Lubbock
Rams work on all aspects of the game
After this week's performance, the Rams anticipate a good season.
The Rams had a three-game sweep over Texas A&M International.
ASU will put their skills to the test as they prepare to battle Lubbock Christian University, another tough team in their lineup, Feb. 14 through Feb. 16.
In the upcoming games, the Rams are trying to eliminate mental and physical mistakes while they are also trying to execute the fundamentals of baseball, infielder Tyler Coughenour said.
Head Coach Kevin Brooks said he is pleased with the start of the season, but he would like to cut back on the amount of strikeouts.
"The team is continuing to stay in routine despite of the cold weather while continuing to get better and better every game," he said.
The players also need work on stealing bases, strikeouts and just little things as time allots, Brooks said.
"At practice we work on every aspect of the game," Coughenour said.
"Base running, defense, hitting and pitching are just some of the things we are working on. We will also set up game-like scenarios to work on situations that might come up during games."
The Rams not only practice their defensive plays, but also work on their offensive plays so they can continue to get better.
"We work on our bunt plays, defensive plays, throwing strikes and situational hitting to prepare us to execute in the games," pitcher Jake Feckley said.
Brooks said he is pleased with how they are playing and how they are competing.
"I think the guys are putting forth great effort," Brooks said. "They are doing a lot of good things."
The Rams are now counting down the days until the Lone Star Conference tournament, which begins on May 8.
"Each game is really important and every game counts the same," Brooks said.
Brooks said that the roles are really undefined on who is getting a lot of playing time. He is hopeful that some players will "step up to the plate" and that certain players will fill shoes to get a better idea of what is ahead for this team.
"It's difficult as a coach because he is not sure which players will be playing and which are not," he said.
Coughenour has already started a successful season with a .526 batting average.
"We still have a lot of aspects of our game that we can get better at," Coughenour said.
"I think our team plays well together as a unit and that we need to stay committed as individuals to improve ourselves daily," Feckley said. "I hope that in future games we continue to win and keep the perfect streak going."
The Rams will start their first game against Lubbock Christian on Friday, Feb. 14, and finish up their set of games in Lubbock on Saturday, Feb. 16.
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Clinical-Style Validation, Regulation, and Quality Control...
Keep the Opportunities, Lose the Opportunists
Loss of Lives in Clinical Trials...
Capitol Hill Critics Second-Guess Agencies Using...
Rhythm obtained $25 million through a Series B financing round. Rhythm will use the proceeds to continue advancing its small-peptide therapeutics for metabolic diseases through Phase II trials. RM-131 is a ghrelin agonist, currently in Phase II, for the treatment of diabetic gastroparesis. RM-493, an agonist of the melanocortin 4 receptor (MC4R), is currently in Phase I trials for the treatment of obesity and diabetes.
"We have made great progress since we started both development programs in 2010, and this could only have been achieved with a strong and dedicated investor syndicate," states Bart Henderson, founder and president of Rhythm. "These programs have great potential for addressing major unmet needs in diabetes, obesity, and gastrointestinal functional disorders, and this financing supports a broad and thorough Phase II development program for both drugs."
All existing investors participated in the round—MPM Capital, New Enterprise Associates, and Third Rock Ventures—as well as new investor, Ipsen. This latest round brings the total capital raised by Rhythm to $65 million.
"Ipsen is impressed with the early results for the ghrelin and MC4 programs as well as Rhythm's track record in executing a precision development program," says Marc de Garidel, chairman and CEO of Ipsen. Rhythm Pharmaceuticals licensed melanocyte-stimulating hormone (MSH) and ghrelin hormone peptide analogue programs from Ipsen in March 2010, at which time both programs were at the preclinical stage.
As part of the deal Ipsen took a 17% equity stake in Rhythm and could earn another $80 million in development and commercial milestones as well as sales royalties. Rhythm will also tap into Ipsen's formulation capabilities and expertise to develop delivery systems for the peptides.
RM-131 and RM-493 both leverage advances in peptide engineering, synthesis, and formulation to enable the design of therapeutics that retain the inherent selectivity and specificity of the human hormones from which they are derived, improve on their potency, and reduce the risk of off-target adverse effects compared with small molecule drugs, according to Rhythm.
RM-131 was derived from the natural ghrelin sequence and optimized to stimulate GI motility, weight gain, and anti-inflammatory activity, with enhanced stability and pharmacokinetics. The compound is suited for GI motility disorders as it reverses both surgical and opiate-induced ileus in animal models due to a direct prokinetic effect, the company notes. RM-131 reverses body weight loss in cachexia models, Rhythm adds.
Development of RM-493 is based on the rationale that a common pathway responsible for suppression of feeding and regulation of energy homeostasis is mediated by the melanocortin type 4 receptor (MC4R). Additionally, in humans, mutations of MC4R are associated with obesity and are estimated to be responsible for 4–6% of all severe obesity. In preclinical studies, when stimulated, MC4R induces a reduction in food intake, body weight, and insulin resistance, according to Rhythm.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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Skip to comments.Central Oregon home to rare white buffalo herd
Posted on 12/12/2010 11:38:25 PM PST by Racehorse
Pendleton Woolen Mills is making new Navajo-style blankets using wool and blended hair shed by an unusual herd of white buffalo in central Oregon.
Ranching experts say fewer than 50 white buffalo, or American bison, live in the U.S., The Oregonian reported.
On a sanctuary east of Bend, 11 of them roam acres of isolated juniper forest under the care of Cynthia Hart-Button and her husband, Charles Button. It's one of the larger collections of white buffalos.
Buffalo usually are black or brown. White buffalo are produced when recessive genes trigger the unusual trait. They are not albino.
Some Native American tribes consider them sacred.
"The significance of the white buffalo has been recognized by all the tribes that are buffalo culture people," Jim Stone, a Yankton-Yanktonai Sioux, told The Oregonian. Stone is executive director of the Intertribal Buffalo Council in Rapid City, S.D., an organization created to restore buffalo to Indian nations.
The white buffalo's presence is a prophesy of spiritual rebirth - "an indicator of better times coming to tribal people," Stone said. "Historically, that has been the view."
The first of the Oregon herd was born in Flagstaff, Ariz., in 1997 into a small herd of black bison owned by Dena Riley and her husband, Jim. Hart-Button worked with the couple for a decade in Flagstaff.
Being in a single, small herd with the right genetic traits stacked the odds in favor of the unlikely white buffalo births, she said. "It's like winning a lottery ticket 11 times."
Hart-Button brought the herd to Oregon five years ago after Jim Riley died and a grieving Dena Riley decided to take a break from raising the buffalo.
(Excerpt) Read more at indiancountrynews.net ...
Humblegunner would not approve..
Is goat granny on a horse, on foot, on another buffalo or on a large goat as she comes over the hill...
I love your remark of an off white beige buffalo...good sense of humor..still chuckling..
Visual Issues?
The keyboard looks the same whether caps-lock is engaged or not.
yep, but for us oldsters its easier to read when we don't have glass's handly and we are hard of hearing...
Silly!! of course she's on a goat. I'm glad you took it as humor, the way I intended it.
No the screen font and my eyes smartass.
New system. Logitech revue.
It has some bugs to work out with software.
Think of a modern webtv. Sony came out with a system too but $500 more and the keyboard they provide is for those effecient at text messaging.
I prefer the old fashion keyboard that came with the Revue as it is easier on the arthretic hands.
Yep and somedays I can't wear glasses because they make my eye allergies and dry eye so bad the eyelids are raw.
My tears/runny eyes literally burn the skin.
Eye doc said it has to due with hormones us older ladies don't produce anymore.
That is ok I was worried all this skin break down was skin cancer. Just gettin' old. And just got my first pair of glasses this year. Now I can see to drive. LOL
This new internet system has a tool to verbally speak.
In multiple language and speeds.
I set my perimeters in slow and British English but the thing doesn't seem to work. Another bug I am working out.
BYW Who looks at the keyboard while typing?
Isn't typing still a required school class?
Oh silly me who actually uses typewriters.
In Michigan the furnace runs for about 7 months out of the year...dry's out the air in the house...
What OTC ointment do you use?
I have been putting neosporin around mine.
I tried some samples of Clinque but not sure if I want to invest in that, I suppose the wrinkles are going to come on at the rate they are regardless.
Having o2/mist concentrators in our room for KV (trach/quad son) I don't need heat on in the winter and actually open the windows to keep us cool. We live on the PNW coast literally so the saline in the air is great for our health needs.
I am so use to sleeping with a fan on my bedside and that is the worst thing next to having a dachshund snuggle in my face.
I clean the fan thouraly and often but that doesn't seem to help it is the air flow that gets my eyes.
I have really bad sleep apnea so the fan along with the o2 helps (cpap was a horrible exp. nightmares of being strangled)
I don't think the settings were right and the guy that services our area is quick to get people into sleep lab but sucks at the follow up.
I am almost wondering if platic is an irratent as my nose canula and glasses seem to cause allot of intense itching.
Speaking of the Son is awake and needing medical care be back after first shift is over.
am sending you freepmail...:O)
Sir, I apologize.
Noli Perturbate.
Buffalo are double coated. It looks to me like they have a whitish outer coat with a brown undercoat, giving them the creamy beige appearance.
It also appears that the undercoat is a good deal lighter than the standard. I bet the calves appear very white and they darken as they age.
I've spun buffalo wool and it is very, very soft, like cashmere or qiviut (yak wool).
The fact that this wool has less pigmentation means that it can be chemically lightened and then dyed in pastels or brights with greater ease and less cost.
Pendleton Blankets are still made in Pendleton, Oregon and they are generally quite pricey. I imagine these will run to several hundred dollars or more as a limited edition.
But they shipped all their clothing manufacturing to Mexico didn't they?
Yes, but the fabric is still woven in mills located here in the U.S. And the wool itself is from U.S. sheep and scoured in their own company owned scouring plant, one of the few remaining in the US.
I did take wool and mohair to a mill and have them card and I'd go pick up the rovings. Usually 1 pound each...We had one ewe for the wool as mohair has no memory and you usually have 15-20% wool before making anything with it.
I use to get natural dyes from a catalog I had and would dye the mohair and wool, some rovings were multi-colored and some just one color...it was fun and I sure did enjoy it...also sold the best locks to doll artists for their wigs.. The doll customers brought in lot more money that the spinners....hand sorting about 500 pounds of mohair to get the best locks for dolls cost them the money for time spent. and since I was a producer I sold cheaper than most other sellers.
Always thought getting a couple of cashmere goats would be interesting. some of the farmers started to cross breed the 2 and called them cashgora's...hoping to get more production from the cashmere cross's....others cross bred with other breeds of goats hoping to get color mohair, but pure, un crossed mohair is always white with one mutation called champagne...If they cross bred back enough you could get a goat that looked like an angora but had color. Most were not successful. but there is fun in the trying....
Pygora (pygmy/angora cross) is popular around here. I bought 3 batches of the roving, 1 white and 2 multi dyed. I've spun the two dyed lots and it was lovely. Haven't done the white yet.
When I first started to spin, I couldn't master the drafting/pedaling either. So I spent a year just plying another spinners stuff for her because she hates plying. Then one day I got to fooling around with some pretty roving and suddenly I could spin.
I have five wheels now and I can tell you that Louet is the most idiot proof and most easily adjusted. All of three of my daughters can spin (youngest is now 13). They are all pretty much self taught and I think they learned young because I let them play with my wheels and always had a box of colorful mill waste roving to practice with.
I've always been a relaxed mother when it comes to sharing my toys, how else will they learn if they aren't allowed to make messes and use stuff?
Although they aren't allowed to play with my new cell phone. How will I learn to program it if they do it for me?
I read once that bison can bread very closely...
Breaded, sauteed, marinated. All sounds good.
Is that wheat or rye?
I'll never *ever* purchase another Pendleton product.
LOL! That's funny!
You are such a colorist. ;o)
I am in the wool business (but I don't work for Pendleton, even though I live only a few miles from them). Only the garment sewing is done in Mexico, thank the garment workers union for that.
But the wool is grown and processed in the USA. The fabric is woven in the USA. I believe they have 6 mills and one scouring plant still here in the US (one of only two left in the US and I'm sure the EPA plans to force them to China someday).
One day her husband went out to feed the ram that they kept in his own pen (nasty disposition) and he pushed the gate in instead of opening it out and entering...the ram saw the bucket of grain and charged the gate. Her hubby got a finger amputated between the gate and the post...
He called the guy that butchered small animals (goats and sheep) and told him he was going to shoot that damn ram and would the guy still process it if he brought him a dead animal....he shot the critter after bandaging his hand and had a couple of neighbors load the carcass into his truck....
I don't know why he got mad at me when I called him lefty four fingers, but I only did it once.....I thought he was going to shoot me too..
The friend who taught me to spin (the one who hates to ply) kept angoras until she got tired of the nasty disposition. Bad attitude must be one of the breed standards, LOL.
She still has a hundred head of ewes on her family farm, mostly Romney, with some merino, cotswald, lincoln, dorset and texel for variety. She keeps 7-10 bucks in a seperate pen and most of them are total sweeties.
Some old ladies collect cats, we collect sheep!
The friend who taught me to spin (the one who hates to ply) kept angoras until she got tired of the nasty disposition. Bad attitude must be one of the breed standards, LOL.
She still has a hundred head of ewes on her family farm, mostly Romney, with some merino, cotswald, lincoln, dorset and texel for variety. She keeps 7-10 bucks in a seperate pen and most of them are total sweeties.
Some old ladies collect cats, we collect sheep!
During breeding season, my breeders were nasty but only had 3 of them. With taking them down to trim hoofs, delouse and worm every 3-4 months we all knew each other. I could do all of the doe's and yearling bucks by myself, but it took me and hubby for the large bucks and neutered males...
I had one that had been a bottle baby and quite sickly when born, we bonded real good and I could let him out of the pasture and he would follow me around the farm. I would take him to the pond and he would trim up the weeping willows for me as far as he could reach. He would walk the farm with me even as an adult..
There were a couple of old nannies that I had to get tough with, but they were the six adults of our original 18 and not born on the farm....
But if you don't spent time with them, they can be cantankerous (usually the males)
But the breeders would be dangerous during breeding...I always eyeballed where the male was during that season before I went into the pasture. They would hurt you real bad. My largest breeder's horns were (somewhere between 44-46 inches from tip to tip) He had to turn his head sideways to get through the barn door....he learned to do that at a full run when I banged on the metal bucket at graining time....If they were at the back of the pasture, the whole flock came running like one big hairy flock...I got out of the way when they got close to the barn, but the grain was already in the feeder.
...hmmm, and to think that I have been so misinformed.
All this time I thought buffalo soldiers had dark curly hair 'n' stuff!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


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If you are here reading this article, I am pretty sure that you must be aware of Email Marketing, if not I suggest you to take a look at How to build Email List by Harsh Agarwal. The Main concern with Internet Marketers is that once they start to build the email list they find it difficult to afford the cost of Email marketing service, and this is where number of beginners fails to build list in spite of all the efforts they put in website. Though there are some free email services available, they charge after certain limit and are restricted to (12 comments)
How To Export Email Addresses of All Commenters on WordPress Blog
Want to grow your email list fast? Want to advertise a product to a highly targeted email list using Facebook or any other forum? Have you ever thought of including commenters' email addresses in your email list? If you are like me and are someone who started with email marketing late, and now you want to find a way to include what you have previously missed, I have a great solution for you. In today's post I will be sharing information about a WordPress plugin that lets you do the following things: Export all approved commenter email (12 comments)
Feedburner vs. Aweber – Which One Is Right For Your Blog?
Are you stuck deciding between Feedburner or Aweber for Email marketing? For nearly a year, I was stuck with the same dilemma you have before you now. In this post, I will share my experiences with Feedburner and Aweber so that by the end of this article, you will be able to determine which program is best for you. When I started blogging in 2008, I began using Feedburner to send email newsletters to people who subscribed to my email list. Feed burner also helped me to fine-tune WordPress's default RSS to make it reader friendly. Later on I (10 comments)
Bloom Plugin By ElegantThemes Will Supercharge Email Marketing
Are you tired of annoying email pop-up form on your blog, which just shows up, but sucks in conversion? Chances are; you are not taking advantage of modern technology such as delay loading, mobile optin form. I have been using Aweber for email-marketing from last five years, and I always find it hard to add email opt-in form on my blog. Problem is not the Aweber; but an easy to use WordPress plugin to add Email Opt-in forms. A perfect WordPress email marketing plugin should at least have following features: Lots of pre-configured (13 comments)
3 Email-Marketing Mobile App From Aweber
2016 is going to be the year of mobile apps and you need to have a solid strategy for your blog marketing on the mobile platform. All foresighted companies have already launched their mobile specific apps and many of them are in the process of developing one. In this article, I will be talking about three mobile apps Curate, Aweber stats and Atom which are from my favourite e-Mail marketing company Aweber. I use Aweber autoresponder to let users subscribe to ShoutMeLoud newsletter ( I also give away an exclusive WordPress guide eBook for free). (4 comments)


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I've just finished building a desktop and would like to install Windows 7 to a SSD and then have the default storage (i.e. Program Files and User folders) on a separate HDD. I've searched for different ways to do this and the most often solution I've seen is modifying the registry entries for those locations to point to the HDD instead of the SSD, but I've also read that doing so after already installing the OS can lead to problems with Windows programs not knowing where they are located.
I've also downloaded RT Seven Lite and Oracle VM Virtualbox in the hopes of modifying my boot disc, but haven't had any luck so far.
So my question: is there a way for me to specify during installation of Windows that I want those directories (Program Files and User folders) to be on the HDD instead of the SSD while still installing the OS onto the SSD?
I apologize if this has been asked or answered elsewhere, my Google-fu has been less than helpful when searching this subject and I'm getting desperate.
Thank you in advance for any help!


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451. wayne0224
Quoting CANTTAKEITANYMORE:not for nothing but i was laughed at for saying it was gonna be a south florida flooding issue.
Member Since: December 1, 2009 Posts: 0 Comments: 146
By: Dr. Jeff Masters , 1:43 PM GMT on October 18, 2011
A large low pressure system off the Florida Gulf Coast, Invest 95L, is bringing heavy rains to Southwest Florida. Rainfall amounts in excess of 3 inches have been common across South Florida since Saturday; Miami has picked up 3.80" as of 9 am EDT this morning, and Key West Naval Air Facility has recorded 14.41", and 14.78" fell on Sugarloaf Key. Key West has experienced other rain events with far more precipitation; their all-time 24-hour rainfall is 23.28", set on November 11, 1980. Interestingly, this is more rain than fell in the entire year of 1974, when Key West received only 19.99".
Rains of 5 - 10 inches have fallen over much of the Florida Keys and Central Cuba since Sunday, according to radar rainfall estimates from the Key West Radar. Long-range radar out of Key West shows that the rain has now pushed north of the Keys, and the region between Naples and Fort Myers is getting the heaviest rains. Satellite loops show that 95L has a respectable amount of heavy thunderstorm activity, but the system is disorganized and has been stretched by wind shear. With wind shear now a high 20 - 30 knots over 95L, development is unlikely, and NHC has dropped their odds of it developing into a tropical depression to 10%. 95L will bring heavy rains of 2 - 3 inches to Southwest Florida today, and NOAA's Storm Prediction Center has placed much of Florida in their "slight risk" area for severe weather, including the possibility of isolated tornadoes.
Figure 1. True-color MODIS image of an interesting 50 km-wide vortex near the north coast of Mexico's Yucatan Peninsula that became the center of 95L late yesterday afternoon. Image taken at 1:45 pm EDT October 17, 2011. Image credit: NASA.
Heavy rains kill 84 in Central America
A week of torrential rains across Central America have triggered extreme floods and landslides that have killed 84 people, with 9 missing, according to media reports. El Salvador and Guatemala have seen the worst flooding, with 32 and 31 people killed, respectively. Another 13 have died in Honduras, and 8 in Nicaragua. The rains were due to a large area of low pressure that was moistened by the landfall of Tropical Depression 12-E near the Mexico/Guatemala border last week. Since the beginning of October, the region near the coast on the Guatemala/El Salvador border has received over 800 mm (31.50") of rain, according to Norman Avila of climaya.com, a Guatemalan weather web site.
Figure 2. Visible satellite animation of the Texas South Plains dust storm of October 17, 2011. Image credit: NWS Lubbock.
Massive dust storm sweeps through the Texas Panhandle
It was a very bad afternoon rush hour yesterday in the Texas Panhandle. A powerful cold front pushed through the state during the afternoon, and damaging north winds behind the front whipped up a dangerous dust storm that cut visibility to near-zero during the afternoon rush hour. Lubbock recorded sustained winds of 48 mph, gusting to 63 mph, with a visibility of 0.2 miles in heavy dust at 5:36 pm CDT. The dust storm was reminiscent of the great dust storms of the 1930s dust bowl era, and was due to the ongoing exceptional drought. Unfortunately, the front brought no rain to the area, and Lubbock has received just 3.16" of rain so far in 2011--more than 13.50" below average. In his Climate Abyss blog, Texas's state climatologist, John Nielsen-Gammon, gives a 25% that the current drought will last five more years. He has an interesting post on how global warming may have affected the drought. He concludes:
Precipitation: The balance of evidence does not support the assertion that the rainfall deficit since October 2010 was made larger or more likely by global warming.
Temperature: Compared to long-term averages of summer temperature, the rainfall deficit accounted for about 4°F of excess heat and global warming accounted for about 1°F of excess heat. Warmer temperatures lead to greater water demand, faster evaporation, and greater drying-out of potential fuels for fire. Thus, the impacts of the drought were enhanced by global warming, much of which has been caused by man.
Video 1. Video of the October 17, 2011 dust storm in Lubbock, Texas.
Jeff Masters
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Dr. Masters co-founded wunderground in 1995. He flew with the NOAA Hurricane Hunters 1986-1990. Co-blogging with him: Bob Henson, @bhensonweather