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adj. describing a type of person who is concurrently intelligent and sarcastic. Typifies the humor of the Daily Show or The Onion.
Noel Coward, Stephen Colbert, Bill Maher and Mark Twain are all masters of smarcastic humor.
by Thor Conner November 14, 2009
Trending Now
Top Definition
A combination of smartass and sarcastic.
Don't be so smarcastic.
by LudwigVan November 13, 2003
A cross between the word Smart Ass and Sarcastic
I don't need your smarcastic remarks right now.
by bosco wordsmith February 04, 2010
A combination of being a smartass and sarcastic.
Tom: This place is a mess.
Haley: Then why don't you clean it up?
Tom: Jeez, what is it with you and being so smarcastic today
Haley: Then why don't you clean it up?
Tom: Jeez, what is it with you and being so smarcastic today
by neonsox4u April 18, 2012
I can not believe that she was being so smarcastic to that boy about really wanting to go on a date with him.
by Mandarin March 22, 2006
smart or smarmy and sacastic or fantastic
Is it possible to use smarcastic in a sentence?
Smacastic Response: Yes it is possible.
Smacastic Response: Yes it is possible.
by Jack King February 17, 2006


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Art & Design
Photographer Without Legs Captures 'One Stare'
Born without legs, photographer Kevin Connolly has spent his life with people staring at him. He recently traveled around the world, taking photos of people looking at him. He sums up his collection, "The Rolling Exhibition," as "15 countries, 31 cities, 32,000 photos and one stare."
Photographer Without Legs Returns Stares
Often, when people see someone who looks different or strange, they stare. Maybe they do it out of the corner of their eye, maybe they gawk, and maybe they get nervous and immediately avert their gaze. People stare, trying to figure out how the object came to be that way.
Kevin Connolly has been getting such stares all his life. That's because he was born without legs.
Connolly was used to drawing double takes in his hometown of Helena, Mont., but when he went to Europe and turned heads there, too, he decided he'd had enough. Connolly got out his camera in Vienna, Austria, and turned it on the people who were staring at him.
"I knew this guy was walking past and staring at me," he says. "I had been getting that sort of attention for weeks — and of course the past 21-odd years as well — but took the photo kind of on a reflex, not thinking about it," Connolly says. "Finding the picture to be really aesthetically pleasing kind of made me pursue the project a bit more."
Connolly began traveling around the world, taking photographs of people looking at him. The stare turned out to be universal, but people in each place had different ideas about why he has no legs. Connolly was seen as a beggar in Vienna, a victim of thalidomide in New Zealand, a holy man in Ukraine, a victim of the Balkan war in Sarajevo, Bosnia-Herzegovina, and an Iraq war veteran back in Montana.
He has collected his photographs in a show he calls "The Rolling Exhibition."
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subset: commoncrawl


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McHale Storm
Not to scold, but -- good God -- if you aren't watching Dan Harmon's Community on NBC Thursdays, you are missing out on some of the best, smartest, weirdest television that's out there. Hyper-self aware, undyingly meta-minded, and, lest we forget, funny, the sitcom features an ensemble of community college students whose leader is Jeff Winger, a disbarred lawyer and terminal ladies' man played by Joel McHale.
McHale's character brings brash cockiness and dry wit to his study group's favorite library table. And it's not unlike the personality he's cultivated as host of the snarky celeb-mocking, reality-skewering E! news show The Soup.
But the comedian is more than good looks, a smartass attitude, and embarrassingly deep pop culture knowledge. His sketch-comedy background gives him a more grounded basis for his stand-up, which revolves largely around his family life and societal observations.
Fri., May 18, 7:30 & 9:45 p.m., 2012
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TOKYO: Japan's Hitachi said yesterday it will provide the world's fastest elevators, which can clock speeds of up to 72 km per hour, to a high-rise building in China.
The lifts will be delivered to the 111-storey, 530-metre-tall Guangzhou CTF Financial Centre due to be opened in the southern Chinese city of Guangzhou in 2016, the electronics and engineering firm said in a press release.
They will be able to travel the length of the 440 metre shaft —from the first to 95th floor — in a stomach-churning 43 seconds.
Hitachi will install a total of 95 elevators at the tower, including two of the superfast lifts, as well as slower machines such as double-decker lifts.
The centre will be the tallest building in Guangzhou, complete with office, hotel and residential space. AFP


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Not Just A Piece Of Cloth
Women are the most marginalized in the 72% of India's population living in rural areas. Given the poor economic status of a vast mass, a sanitary napkin for the essential biological process of menses is the last thing on the mind of most. They end up using all kinds of rags leading to widespread unhealthy practices during menses. This forms a strong connect with the prevalence of RTI and other pelvic diseases in India. The shame & silence associated with the issue makes it the most taboo subject even among women, as a vast majority face great hardships & indignity, besides health risks due to this problem.
Goonj is using old cloth lying useless in the cities as a resource to address this important yet taboo basic need of the village & slum women and in doing so focusing on a critical gap in women's health. The clean cloth napkins are an entry point to generate more awareness on the related health and hygiene issues. In the cities for the first time we are initiating discussion on this issue by directly involving the urban women, drawing on their instinctive empathy. The use of cloth; a material most village women are comfortable and familiar with, coupled with the reuse possibilities makes it a viable option.
Recent media coverage
1. Asian Tribune wrote "Movie with four friends or dignity for four women in 'those days' www.asiantribune.com/node/61865 All it takes is US $ 24 or Indian Rupees 1,000 to bring dignity to how a women deals with this monthly basic need. The choice is yours…
2. A Podcast with Anshu Gupta, Ashoka Fellow and Schwab Fellow, the man behind Goonj's pioneering work on the ignored and taboo basic need of a woman in rural India. Highlights the thought process and philosophy of Goonj – 'Creating Paradigms: Where Trash is Currency' - www.khemkafoundation.org/index.php?option=com_k2&view=item&id=242&Itemid=259
3. Session at NASA: Using urban waste streams as a powerful development resource in rural India, Goonj is dedicated to saving lives, empowering people, and ensuring dignity for the underserved poor in rural India. Through its activities, Goonj helps to create a parallel economy that is not 'cash based', but 'trash based' - http://www.youtube.com/watch?v=daZP09zGHLA&feature=youtu.be&noredirect=1
4. David Bornstein of The New York Times wrote about the journey of Goonj to create shelter for people in rural areas using the so called urban discard. "Bridging the Clothing Divide" http://opinionator.blogs.nytimes.com/2012/10/03/clothing-the-poorest-for-survival/
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The Cary Crush Girls Fastpitch Softball Program and the
Crystal Lake Tidal Waves Fastpitch Organizations are
proud to announce the combining of our organizations.
Crush Tidal Waves Travel Fastpitch Tryouts for 2015
Elite "A" teams at the 12U, 14U, 15U, 16U and 18U levels
"B" Level teams at each level also
Tryouts at Lions Park - 1200 Silver Lake Road, Cary, IL 60013
10U team Saturday 8/2 and Sunday 8/3 10:15am-12:15pm
11U and 12U teams Saturday 8/2 and Sunday 8/3 12:15pm-3:15pm
13U and 14U teams Saturday 8/2 and Sunday 8/3 3:15pm-6:15pm
15U and 16U teams Saturday 8/9 and Sunday 8/10 10am-1pm
18U teams Saturday 8/9 and Sunday 8/10 1pm-4pm
Register on line at either www.carycrush.org or www.tidalwaves.org
Contact Director of Tryouts Mike Johnson at firstname.lastname@example.com with any questions
ACTIVE is the leader in online event registrations from 5k running races and marathons to softball leagues and local events. ACTIVE also makes it easy to learn and prepare for all the things you love to do with expert resources, training plans and fitness calculators.


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Warren Buffett Is Sick and Tired of the Crisis, the Government, All of You People
The Oracle lashes out.
A cranky Warren Buffett lashed out at the government's proposed "financial responsibility tax" on CNBC this morning, which he called "some kind of a guilt tax."
What was done in the fall of 2008 was designed to save the American economy. It wasn't designed to save the banks, it wasn't designed to save me. It was designed to save 300 million Americans and a good job was done. And the banks are the ones, you know, they paid it back with huge interest. The government's made a lot of money off Wells. They've made a lot of money off Goldman. They've made a lot of money off J. P Morgan. And to say that they should be paying for the fact that the government lost a lot, or may lose a lot of money in Freddie and Fannie and perhaps with the auto companies, it just doesn't make any sense to me. Are you going to go and tax the members of congress who ran Freddie and Fannie? The American people love the idea of Goldman or AIG or anybody like that, those are bad names. They don't think so much about Freddie or Fannie which are that expensive and which Congress ran. I think a tax that's enacted with the idea that the headlines will be appealing and that a certain amount of vengeance will be achieved, I don't think that's the greatest form of tax policy.
Sounds like Warren's blood sugar is a little low. Someone get him a milkshake and a bag of caramel popcorn, stat. Then can we get him into public office, finally?


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Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Released: Nov 01st, 2006
Running Time: 170
Director: David Luger
Company: Platinum X
Cast: Brian Pumper, Tee Reel, Rio Mariah, Victoria Lan, Sledge Hammer, Nataly Rosa, Celina Cross, Tyler Knight, Vanessa Figueroa, Melissa Martinez
Critical Rating: AAA 1/2
Genre: All-Sex
How some of these small-framed Latin beauties are managing to stuff their holes with the prodigious black meat they're presented with is sometimes a bit of a wonder, but they yell and moan and bite the sheets through it all like troopers. Not all the girls put in the most enthusiastic performances, but there's nothing to snore at either. David Luger's direction is simple but captures all the action well, and at almost three, each girl is given ample time to show her stuff.
Melissa Marinez's cock sucking is a noble effort, cramming the cock down her little throat as best she can. But it's Rio Mariah's closer as she takes on two huge guys in a scorching d.p. and slutty grind fest that leaves one sweaty. It's almost a dare as she stares up at the two, urging them to fill her more.
Retailing: For your biracial section.


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Here are my latest observations of the top rooks in summer-league action:
Also, click here for my Rookie 50 rankings.
Russell Westbrook, Oklahoma City
Turns out he's a better offensive player than he showed at UCLA. And he is already a top-10 athlete in the NBA right now. His defensive efforts, though, are what got him drafted, and he'll improve his team on that end immediately. The best rookie point guard of the summer.
Jerryd Bayless, Blazers
He's dynamite as an attack man, and his shooting ability makes him even tougher to defend. He's unique among guards because he craves contact and paint drives. He's ready to contribute off the bench for Portland, but he might get caught behind veterans at the start of the season. The best rookie combo guard of the summer.
Anthony Randolph, Warriors
If teams drafted players based solely on upside, Randolph would have been a top-5 pick. He showed more pure talent than anyone, Michael Beasley included, this summer. Played five positions and made every play imaginable on both ends. He has so much to learn about being an NBA player, with much of it relating to off-the-court growth. The best rookie small forward of the summer.
Jason Thompson, Kings
Scouts rave about his speed. I love his hands. He mixes it up well around the rim and looks like he'll be an effective player out on the floor. The best rookie power forward of the summer.
Kevin Love, Timberwolves
Not just a brilliant outlet passer, he also makes quick, perfect passes from the pinch post. Al Jefferson will love running high-low action with him. And yes, Minnesota's athletic wings will dunk more (as long as they race the floor), thanks to Love's uncanny ability to survey the floor and deliver a perfect 30-foot pass. The best rookie center of the summer.
Derrick Rose, Bulls
Wish I could have seen him more -- and healthier -- in Orlando. I still think he'll be an excellent lead guard who will make things happen for his teammates on both ends of the floor.
O.J. Mayo, Grizzlies
I don't see a lot of upside with him, but I don't see much of a downside either. His ability to get open jumpers off the dribble is nice, and he competes pretty hard. But he's not special as an athlete, so his ability to blow by people is average at best. Learning the "shot-fake attack game" will help him a great deal.
Brook Lopez, Nets
Showed some immaturity in Utah that I didn't see in Orlando; he played with a scowl and lacked bounce. He'll soon learn that without intensity and passion in his play, he's going to be a liability to his team. If he can combine his skill set inside with an energetic effort level, he'll be a huge help to the Nets.
Marreese Speights, Sixers
I worked out Speights one time two years ago and thought he was the closest thing to Amare Stoudemire that I'd ever seen. I still think that. He is incredibly agile and explosive for such a big man, and his skill game is superb. He throws the ball in, period. Sitting behind so many players in Philly will not help spur development, but I suspect his coaches understand that and will work to keep him engaged.
Donte Greene, Rockets
The Kevin Durant comparison is an accurate one. When he settles for being just a long-range shooter, he's an ordinary player (at the NBA level). But if he's active as a cutter, sprints the floor in transition and looks to make plays inside, he's a special offensive talent. Just like KD.
Courtney Lee, Magic
The Magic drafted him largely because of his ability to defend and shoot from outside. During summer league, he didn't disappoint on either end. Stan Van Gundy needs his guards to be aggressive offensively, creating open lanes for Rashard Lewis, Hedo Turkoglu and Dwight Howard. Seeing Lee average 20 points per game -- along with the addition of Mickael Pietrus -- has the Magic faithful feeling great about their team's offseason moves.
Kosta Koufos, Jazz
Coordinated, but slow, with a good frame. Looks like he likes to face up and shoot, but his shot looks flat now. Does an excellent job absorbing contact on shots inside; keeps his shoulders square on finishes. His capacity for work is very high, so rapid improvement is a fair expectation.
• Click here for Thorpe's Rookie 50 rankings and more observations
David Thorpe is an NBA analyst for ESPN.com and the executive director of the Pro Training Center at the IMG Academies in Bradenton, Fla., where he oversees the player development program for NBA and college players. To e-mail him, click here.


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1825 Place
15835 Foothill Farms Loop
Pflugerville, TX 78660
(512) 252-3500
At 1825 Place we have something for everyone! With 10 distinct floor plans you will be sure to find the perfect apartment home that will fit your needs. Come take a dip in our sparkling pool or get your heart rate pumping in our 24 hour fitness center. Our premier Pflugerville location offers access to entertainment and the finest in shopping and dining. All just minutes from the action and culture in downtown Austin. Call or stop by to schedule a tour, you won't find a community that offers you more!


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Property Location
With a stay at Villas Tiburon in Holbox Island, you'll be convenient to Main Square and Holbox Church. This beach hotel is within close proximity of Punta Mosquito Beach and Yalahau Lagoon.
Make yourself at home in one of the 15 air-conditioned guestrooms. Bathrooms with showers are provided.
Enjoy the recreation opportunities such as a private beach or make use of other amenities including complimentary wireless Internet access.
Continental breakfasts are available for a fee.


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Leonise Toups
Published: Thursday, August 4, 2005 at 11:14 a.m.
Last Modified: Thursday, August 4, 2005 at 11:11 a.m.
Leonise P. Toups, 86, a native of Galliano and resident of Cut Off, died at 12:20 p.m. Tuesday, Aug. 2, 2005.
Visitation will be from 1 to 10 p.m. today at Falgout Funeral Home in Galliano and from 9:30 a.m. to funeral time Friday at Sacred Heart Catholic Church in Cut Off. Mass will be at 11 a.m. Friday at the church, with interment in the church mausoleum.
He is survived by one son, Larry Paul Toups and wife, Dina; two daughters, Barbara T. Falgout and Beverly T. Sonnamaker and husband, Charles; three sisters, Rose Pierce, Earline Pitre and Wilavia Chiasson; eight grandchildren, Denise Matthews, L. Paul Toups, Jennifer Shelton, Kevin Toups, Dena Fernell, Lance Toups, Reed Fanguy and Kelli McNamara; and eight great-grandchildren, Gavin Toups, Rory Fernell, Kelsey Fernell, Darcey Fernell, Denae Matthews, Melyssa Matthews, Maygan Steele and Cole Steele.
He was preceded in death by his wife, Rita Bouzigard Toups; his parents, Remie Sr. and Angelina Gisclair Toups; one son, Leonise J. Toups Jr.; five brothers, Remie Jr., Lodess J., Loris, David and Noless Toups; three sisters, Leona Anselmi, Noiscia Duet and Elescia Bouffanie; and one son-in-law, Dennis George J. Falgout.
He was a retired commercial shrimper, fur trapper and horticulturist raising fruits and vegetables.
He was a 3rd degree Knights of Columbus, a member of the Holy Name Society and a parishioner of Sacred Heart Catholic Church.
Falgout Funeral Home is in charge of arrangements.
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"We're really frustrated right now," Pacers forward Tyler Hansbrough said. "I know I'm frustrated. We now have to work to stay in this series and win our game here at home."
HEAT 100, 76ERS 94: At Philadelphia, hours before Game 3 of the Heat-Sixers first-round series, Dwyane Wade had that big-game feeling.
Wade's 36 miserable hours of migraine headaches had passed, his head was clear and his game, well, he'd prove his game was back in championship form.
"I don't have to worry about bright lights," Wade said.
Was he ever fantastic under the postseason spotlight.
Wade had 32 points and 10 rebounds, LeBron James finished with 24 points and 15 boards and the Miami Heat took a 3-0 lead in their first-round series against the Philadelphia 76ers with a 100-94 victory Thursday night.
"I felt a lot better," Wade said. "My game felt better. I think my teammates could see it."
The Heat saw it from the opening tip. Wade was driving, attacking, dunking — playing his game at full blast the way he couldn't in Game 2. He even fought through another familiar malady, a banged-up shoulder that needed ice and treatment.
Wade delivered with a string of big baskets — he was 10 of 19 from the field overall — in the third and fourth quarters that spurred the Heat to the brink of the conference semifinals. He drew a foul on a spin move against Jrue Holiday and hit two free throws with 51.6 seconds left that about clinched the game.
Wade missed practice before Game 2 with a migraine headache. He was slowed in Game 2 by the lingering effects of the headache and scored a combined 31 points in the first two games.
"He understood we needed something a little bit more," Heat coach Erik Spoelstra said.
Wade was 12-for-12 from the free throw line. For all the hype around the Big Three, Wade remembers he was the Biggest One in Miami. He still plays that way and the Heat needed all of his all-around excellence against the scrappy Sixers.
Chris Bosh scored 19 points for the Heat, who rallied from an early 10-point deficit to move within one win of a sweep of the Eastern Conference series.
Game 4 is Sunday in Philadelphia.
"This is what we envisioned," James said.
James gave the Heat a late scare when he fell late in the fourth quarter and briefly sat against the scorer's table. He grimaced when his teammates pulled him up and he slowly walked back to Miami's bench.
James brushed off questions about a possible tender ankle, said he was fine and will be ready for Sunday.
"We're a desperate team right now," James said. "We want to continue to play that way. D-Wade had an unbelievable game ... and we're ready to close it out."
The Sixers were determined to win one on their home court and played like a team trying all it could to get the series back to Miami.
Lou Williams missed a 3 with 43 seconds left that would have made it a one-point game. Holiday scored 20 points, Williams finished with 15 and Elton Brand had 21 points and 11 rebounds for the 76ers.
TRAIL BLAZERS 97, MAVERICKS 92: At Portland, Ore., Wesley Matthews scored 25 points and LaMarcus Aldridge added 20 as the Trail Blazers beat Dallas to trim their first-round playoff deficit to 2-1.
Andre Miller and Brandon Roy added 16 points apiece for Portland, which led by as many as 13 points in the fourth quarter.
Jason Terry scored 29 points on the strength of five 3-points, and Dirk Nowitzki had 25 with nine rebounds for Dallas, but no other Mavs player scored more than nine points.
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AURORA — Evergreen's boys soccer program is one win away from its first state championship since 1989.
The Cougars upset top-seeded Cheyenne Mountain 4-3 in a thrilling Class 4A semifinal Nov. 11 at Legacy Stadium in Aurora. Evergreen freshman Ryan Gutberlet scored a pair of goals, including the eventual game-winner in the 78th minute, to propel the No. 4 Cougars to their first trip to the title game since 2011.
To better manage events in its parks, Jeffco Open Space is establishing new guidelines, which the Open Space Advisory Committee reviewed on Nov. 5.
Events attended by more than 200 people will be limited to five per year, with a maximum of one for each user type, said Dave Davenport, Open Space's outdoor recreation coordinator.
Also, events that fall on holidays or holiday weekends will not be considered, according to the revised park-permit guidelines.
There is a small drainage pond below my window that has become a miniature cattail marsh. Last week, the green fronds were waving in the breeze, but the snow that came midweek also brought some very cold temperatures.
When I awoke Thursday morning, the snow had turned Our Evergreen World to white and the cattails were stiff and brown, rattling in the wind. Summer has left the little marsh, and it now serves as a wintering place for a few birds.
Locals compete at state
Evergreen placed sixth in the Class 4A state gymnastics team standings Nov. 6 at Thornton High School. Grace Kishimoto had the best finish in the individual all-around, taking 13th. Teammate Alexa Endsley placed 17th and Sadie Rhoades-Barnes took 21st. Margaret Streett and Mira Zizic closed out the all-around placers for the Cougars, finishing 24th and 25th. On Nov. 7, Kishimoto placed 11th in the bars and Rhoades-Barnes placed eighth in the beam individual event finals.
By Craig Harper — For the Courier
EVERGREEN — Facing a 2-0 deficit in a match that would determine a berth in the state Class 4A volleyball tournament, Evergreen's Liz Hudd followed standard coaching procedure by tinkering with her lineup.
But during the break prior to the third set, Hudd took an unconventional tack: yoga.
LAKEWOOD — Evergreen coach Rob Molholm had plenty of restless nights preparing for D'Evelyn senior quarterback Owen Burke.
"Owen is a heck of a quarterback," Molholm said "He gave me nightmares all week long. Boy, did he have me stressed."
Molholm's defense was the ultimate cure for his anxiety heading into the showdown against D'Evelyn on Nov. 6 that determined the Class 3A Metro North League champion.
EVERGREEN — With most of the pieces back from Evergreen's 2014 boys soccer team, this year's run to the Class 4A semifinals was not unanticipated.
The return of Brock Anderson solidified it.
EVERGREEN — Evergreen senior Hayden Cogswell hadn't scored a goal in nearly two months.
The speedy midfielder picked a perfect time to end his goal-scoring drought with the eventual game-winning goal Nov. 3 in the Class 4A boys soccer second-round playoff game at Evergreen High School. Cogswell scored his second goal of the season on a rocket of a shot past Palmer Ridge goalie Mason Cresap in the 20th minute to give the Cougars a 2-1 lead.
November is often referred to as the brown month. Nightly frosts have put an end to the green growing season, and meadows and prairies have slowly turned brown.
Although we may have snow, there is seldom enough to stay on the ground for long, and before we settle into the black-and-white days of winter, we have about a month of brown frozen weeds and grasses. November is usually the month when the summer growth has matured and ripened seeds.
League title on the line
Evergreen and D'Evelyn will decide the Class 3A Metro North League football title 7:30 p.m. Friday, Nov. 6, at Trailblazer Stadium in Lakewood. Both enter the showdown with identical 7-2 overall and 4-0 conference records. The game will also be key for the postseason, which begins next week. The Colorado High School Activities Association will release the 16-team 3A state tournament bracket Sunday, Nov. 8.
Copyright © 2016
Canyon Courier is your source for local news, sports, events, and information in Evergreen, Colo, and the surrounding area.


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O Pioneers! (Paperback)
One of America's greatest women writers, Willa Cather established her talent and her reputation with this extraordinary novel the first of her books set on the Nebraska frontier. A tale of the prairie land encountered by America's Swedish, Czech, Bohemian, and French immigrants, as well as a story of how the land challenged them, changed them, and, in some cases, defeated them, Cather's novel is a uniquely American epic.
Alexandra Bergson, a young Swedish immigrant girl who inherits her father's farm and must transform it from raw prairie into a prosperous enterprise, is the first of Cather's great heroines all of them women of strong will and an even stronger desire to overcome adversity and succeed. But the wild land itself is an equally important character in Cather's books, and her descriptions of it are so evocative, lush, and moving that they provoked writer Rebecca West to say of her: The most sensuous of writers, Willa Cather builds her imagined world almost as solidly as our five senses build the universe around us.
Willa Cather, perhaps more than any other American writer, was able to re-create the real drama of the pioneers, capturing for later generations a time, a place, and a spirit that has become part of our national heritage.
About the Author
A Pulitzer Prize-winning author, Willa Cather s work was profoundly influenced by her upbringing in rural Nebraska. During her young adulthood Cather proved herself intelligent and capable, initially training for a career as a medical doctor, but discovered a love of, and talent for, writing while attending the University of Nebraska. Following graduation, Cather worked as a journalist for several women s magazines before becoming a high school teacher; an opportunity work as an editor at McClure s provided Cather with her first chance to publish as the magazine serialized her first novel, Alexander s Bridge, to critical acclaim. This was soon followed by works that have since become best-loved American classics, including My ?ntonia, The Song of the Lark, and her Pulitzer-Prize winner, One of Ours. Cather died in 1947 at the age of 73.
Praise For…
The land belongs to the future... that's the way it seems to me....I might as well try to will the sunset over there to my brother's children. We come and go, but the land is always here. And the people who love it and understand it are the people who own it -- for a little while."
O Pioneers! (1913) was Willa Cather's first great novel, and to many it remains her unchallenged masterpiece. No other work of fiction so faithfully conveys both the sharp physical realities and the mythic sweep of the transformation of the American frontier -- and the transformation of the people who settled it. Cather's heroine is Alexandra Bergson, who arrives on the wind-blasted prairie of Hanover, Nebraska, as a girl and grows up to make it a prosperous farm. But this archetypal success story is darkened by loss, and Alexandra's devotion to the land may come at the cost of love itself.
At once a sophisticated pastoral and a prototype for later feminist novels, O Pioneers! is a work in which triumph is inextricably enmeshed with tragedy, a story of people who do not claim a land so much as they submit to it and, in the process, become greater than they were.


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Jell-O 'Turns Frowns Upside-Down' Via Twitter
Using a 'mood monitor' to scans the number of smilie ":)" or sad ":(" faces on Twitter, the Kraft Foods brand will 'help spread the happy' by sending jell-o pudding coupons out to sad tweeters
Jell-O are looking to push the snack=happiness association even closer with a new campaign on Twitter.
Using a 'mood monitor' to scan the number of smiley ":)" or sad ":(" faces on Twitter, the Kraft Foods brand will 'help spread the happy' by sending jell-o pudding coupons out to sad tweeters. The promotion is only activated when the 'national twitter mood' drops with less than 51% smiley emoticons. Random frown-faced users will be tweeted by the company, needing only to respond with a 'pudding face' ":D" to receive their coupon.
[via AdAge]


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Failing government prompts Irish exodus
Irish voters go to the polls this week as an ailing economy is forcing record numbers of disillusioned citizens to flee the country in search of a better life overseas.
Less than three months after the government accepted an international bailout worth $115 billion to rescue an economy on life support, the public is furious with the entire political class.
Fianna Fail is the centre-left party which has been in government for 60 of the 89 years of Ireland's independence.
Polls indicate they will be trounced in Friday's election and will be lucky to come away with 20 seats out of a possible 166.
Until three years ago, the little country the size of Tasmania was experiencing 6 per cent growth and was the envy of Europe.
Low taxes kept foreign firms investing, but the people who became known as the I-rich became obsessed with property - not buying and selling, but building.
Banks and developers, encouraged by the government, got so carried away in some areas that they built more houses than there were families to fill them.
Now there are 300,000 homes lying empty in what have come to be known as "ghost estates".
Finance minister Brian Lenihan admits it was wrong to allow the construction sector to become so big.
"We had an unsustainable building boom, construction boom in this country from 2003 to 2008," he said.
"My party leader has taken full responsibility for this. So have I."
History repeating
In a case of history repeating itself, residents of County Mayo in the west of Ireland are emigrating in what is expected to be record numbers.
It is the same place from which many of the famine boats left back in the 1840s when a wave of emigration washed 1 million people away from the country.
Close to 500,000 fled the country in the 1980s and now they are off again, with around 1,000 people heading for the exits every week.
Electrician Alan Niland is one of those leaving Mayo in search of a better life.
"Leaving here is a big thing and everyone doesn't want to go. It's a last resort really," he said.
At a seminar on the outskirts of Dublin, an audience of 700 arrives for a monthly information night on economic opportunities in Australia.
Australian visa applications from Dublin in the past 12 months are up 60 per cent, and one local said employment opportunities in Ireland were so dire that he had to make a change.
"By working it out and making the big trip and the big change over to Australia for better opportunities for ourselves and the kiddies," he said.
Others expressed similar sentiments on work prospects.
"I've been working the last 25 years. [For the] first time in my life I am unemployed. To be honest I don't see any prospects of employment in the near future," one said.
"There's no way I want to bring kids up here, especially after being over in Australia and seeing what it's like and talking to people. I basically just made my mind up when I got there," said another.
'Degenerate bust'
Former Irish central bank economist David McWilliams is credited with being the first to have warned of a credit crisis looming back in 2001.
"We've never had a boom before so in a way our boom was much more amplified, because it was totally new and unfortunately our bust is much more degenerate," he said.
"We went from being a country with a banking system to a banking system with a country stuck onto it, because the banking system became three times bigger than the gross national product of the country, which is kind of phenomenal."
Immigration may well have become the hottest topic of this election campaign, but those who leave the country no longer have a say in Ireland's future.
On departure day they lose the right to vote.
- Watch Emma Alberici's full report, Goodbye, My Ireland, on Foreign Correspondent tonight on ABC 1 at 8:00pm.
Topics: world-politics, business-economics-and-finance, economic-trends, international-financial-crisis, government-and-politics, ireland, australia
First posted


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Meet Our Chaplains
Penny Abbott joined the Chaplaincy Department as Secretary in 2006. Prior to joining the department she served as Secretary for the Director of Purchasing at DHMC, and as Grant Secretary/Receptionist at the Howard Dean Education Center in Springfield, VT. She has also been a member of the Vermont State Board of Christian Education for the United Church of Christ and has served her local church as Deacon, youth group leader, and Sunday School teacher.
Rev. Kris Bowen joined the Chaplaincy staff in 2011. Her primary assignments are as the Pediatrics chaplain on the CHaD team and as the Emergency Department chaplain. Kris holds a Master of Divinity degree from Andover Newton Theological School. She is ordained in the United Church of Christ and enjoys being an interfaith chaplain, which allows her the honor of getting to work with patients and families from many different faith traditions and spiritualties. Kris is board-certified by the Association of Professional Chaplains.
Chaplain Jeanne Childs, MA, BCC is board-certified by the National Association of Catholic Chaplains. Jeanne joined the Chaplaincy Department as staff chaplain for the Dartmouth-Hitchcock Aging Resource Center in 2009 after completing a fellowship in geriatric chaplaincy and a five year program of Clinical Pastoral Education at DHMC. Jeanne is a graduate of the University of San Diego and St. Michael's College.
Rev. Frank Mächt, Director of Chaplaincy, joined DHMC in 2011. He is an ordained pastor in the Evangelical Lutheran Church in America and an ACPE-certified Clinical Pastoral Education Supervisor. He studied theology at the universities of Frankfurt and Münster before graduating with an M.Div. and M.A. from Pacific School of Religion in Berkeley, CA. Subsequently he pursued clinical training at Stanford University, Presbyterian Hospital in Albuquerque, NM, and at Emory University in Atlanta, GA, where he was specialized in workplace chaplaincy. Frank especially enjoys cross-cultural learning and ministry. He served as pastor of a multi-cultural congregation in Nome, AK and in the spiritual care department of a faith-based hospital in Anchorage, before joining DHMC.
Rev. John D. S. Nwagbaraocha is a Board Certified Chaplain (2004) and has been an active member of the National Association of Catholic Chaplains since 1999. He studied Philosophy & Theology at Bigard Memorial Seminary in Enugu, Nigeria. Fr. John was ordained as a Catholic priest in 1980. After ordination, he served as an associate pastor, pastor, chaplain, Dean and diocesan councilor before moving to the U.S in 1998. Fr. John served in parish and hospital ministries in Louisiana prior to joining Fletcher Allen Health Care in 2000. He completed a program of Clinical Pastoral Education at Fletcher Allen Healthcare and holds an M.A. degree in Theology from St. Michael's College. He is an active Rotarian.
Rev. Samuel Seyd is originally from Pakistan (Punjab). He joined St. Thomas the Apostle Seminary right out of high school. He attended National Catholic Institute of Theology (Karachi) for the study of Philosophy and Theology and was ordained a priest in 2000. He received his Master's in Theology from University of California. In 2008 he completed Clinical Pastoral Education from the Hartford Hospital.
Rev. Stephen Warfield, M.Div., BCC joined the chaplaincy staff in 2015 and is board certified through the Association of Professional Chaplains. After a career in marketing and development, Stephen transitioned into professional chaplaincy. He earned a M.Div., completed four units of CPE at Wake Medical Center in Raleigh, NC and the Durham VA Medical Center in Durham, NC, and served as a staff chaplain at Saint Alphonsus Regional Medical Center in Boise, ID. In addition, Stephen is a chaplain in the United States Navy Reserve and is a veteran of Operation Enduring Freedom. His research interests include person-centered chaplaincy, interfaith dialogue, care of military personnel and veterans, disaster/trauma chaplaincy, and the global professionalization of chaplaincy. Stephen's clinical assignments are Emergency Department, Medical Specialties, and ICU.
Rev. Nancy Wood serves as the staff chaplain for the DHMC Palliative Care Service. Before joining the chaplaincy staff in 2015, Nancy worked as an interfaith chaplain for a small hospital and a regional hospice, and served several congregations. An ordained United Church of Christ minister, Nancy is a graduate of Harvard Divinity School and is board-certified by the Association of Professional Chaplains.


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8-Bit Spaceship
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Rated 5 / 5 stars
This... this... wow...
There is no other word to describe than amazing :) especially the end.
Them feels. Makes me remember the good days.
Rated 5 / 5 stars
I DIDNt write a review on this ._.
This song is great espically the ending.... you killed it with that ending that brought up some childhood memories hehe thats why i always loved this song
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This is my favourite Song on newgrounds i just wanted you to know that (::
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:D Im Happy that ...
this sounds really familiar......
Rated 4 / 5 stars
Nicely done meh friend
Bit Shifter here. I am in love with all bits. Me and meh friend are designing a game right now for the wii for a class project. Would u believe it WII XD. anyway were gonna put it on ps3 instead soooo ya :D. Also nicely done again!
Your Bit Masta


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Imagine you're locked inside of an abandoned building where undercover operations were launched during the Cold ... read more...
888-655-2278, 918-596-2700
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The Gilcrease Museum contains one of the world's most comprehensive collections of American Indian and Western art. ... read more...
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Tulsa, OK 74171
Oral Roberts University in Tulsa is home to a sculpture known as the world's largest praying hands. It is also the ... read more...
Hardesty Regional Library
Tulsa, OK 74114
Located in Tulsa's Hardesty Regional Library, the Tulsa Genealogy Center houses an abundance of genealogy resources. ... read more...
Tulsa Historical Society & Museum
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The Tulsa Historical Society & Museum's mission is to illuminate the past, enrich the present, and inspire ... read more...
332 E 1st St
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Head to El Guapo's roof to enjoy great Mexican food and amazing views of Tulsa's downtown skyline. El Guapo's, located ... read more...
317 S Main St
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Art gallery specializing in Native American art. We feature paintings, sculptures, pottery, prints and much more. ... read more...
4145 E 21st
Tulsa, OK 74114
Horse racetrack and simulcast center. Live horse racing in June and July with simulcasting daily. ... read more...
Email: firstname.lastname@example.com


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dpreviewShared publicly -
Japan Hobby Tool has announced a set of 'urban camouflage' covers for the Nikon 1 system cameras. In stark contrast to the nostalgia-tinged Gariz leather cases we've seen for various cameras, the Japan Hobby Tool coverings are distinctly modern, featuring a stylized pixelated monochrome design. http://ow.ly/cJ9x0
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WASHINGTON (September 16, 2013)--The gap in employment rates between America's highest and lowest-income families has grown to its widest since officials began tracking the data a decade ago, according to an analysis of government data conducted for The Associated Press.
The analysis shows that U.S. households with income of more than $150,000 a year have an unemployment rate of 3.2 percent, a level traditionally defined as full employment.
At the same time, middle-income workers are increasingly pushed into lower-wage jobs, displacing lower-skilled, low-income workers, who become unemployed or are forced to work fewer hours.
Rates of unemployment for the lowest-income families have topped 21 percent.
Harvard economist Richard Freeman says the findings show that people at the bottom will continue to be financially squeezed.


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Giulio Savia MD passed away on February 2009.
Effects of Beta-Blockade on Exercise Performance at High Altitude: A Randomized, Placebo-Controlled Trial Comparing the Efficacy of Nebivolol versus Carvedilol in Healthy Subjects
Version of Record online: 11 MAR 2011
DOI: 10.1111/j.1755-5922.2011.00261.x
© 2011 Blackwell Publishing Ltd
Cardiovascular Therapeutics
Volume 30, Issue 4, pages 240–248, August 2012
Additional Information
How to Cite
Valentini, M., Revera, M., Bilo, G., Caldara, G., Savia, G., Styczkiewicz, K., Parati, S., Gregorini, F., Faini, A., Branzi, G., Malfatto, G., Magrì, D., Agostoni, P. and Parati, G. (2012), Effects of Beta-Blockade on Exercise Performance at High Altitude: A Randomized, Placebo-Controlled Trial Comparing the Efficacy of Nebivolol versus Carvedilol in Healthy Subjects. Cardiovascular Therapeutics, 30: 240–248. doi: 10.1111/j.1755-5922.2011.00261.x
This work was performed at the Capanna Regina Margherita, a shelter on top of Monte Rosa, Italian-Swiss Alps, at 4559 m above sea level, and at the S. Luca Hospital, IRCCS, Istituto Auxologico Italiano; Via Spagnoletto, 3. 20149, Milan, Italy.
Publication History
- Issue online: 3 JUL 2012
- Version of Record online: 11 MAR 2011
- Abstract
- Article
- References
- Cited By
- Autonomic nervous system;
- Beta receptor;
- Adrenergic receptor blockade;
- Cardiopulmonary exercise test;
- Carvedilol;
- Clinica trial;
- Hypoxia;
- Nebivolol
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
Exposure to high altitude (HA) hypoxia decreases exercise performance in healthy subjects. Although β-blockers are known to affect exercise capacity in normoxia, no data are available comparing selective and nonselective β-adrenergic blockade on exercise performance in healthy subjects acutely exposed to HA hypoxia. We compared the impact of nebivolol and carvedilol on exercise capacity in healthy subjects acutely exposed to HA hypobaric hypoxia.
In this double-blind, placebo-controlled trial, 27 healthy untrained sea-level (SL) residents (15 males, age 38.3 ± 12.8 years) were randomized to placebo (n = 9), carvedilol 25 mg b.i.d. (n = 9), or nebivolol 5 mg o.d. (n = 9). Primary endpoints were measures of exercise performance evaluated by cardiopulmonary exercise testing at sea level without treatment, and after at least 3 weeks of treatment, both at SL and shortly after arrival at HA (4559 m).
HA hypoxia significantly decreased resting and peak oxygen saturation, peak workload, VO2, and heart rate (HR) (P < 0.01). Changes from SL (no treatment) differed among treatments: (1) peak VO2 was better preserved with nebivolol (–22.5%) than with carvedilol (–37.6%) (P < 0.01); (2) peak HR decreased with carvedilol (–43.9 ± 11.9 beats/min) more than with nebivolol (–24.8 ± 13.6 beats/min) (P < 0.05); (3) peak minute ventilation (VE) decreased with carvedilol (–9.3%) and increased with nebivolol (+15.2%) (P= 0.053). Only peak VE changes independently predicted changes in peak VO2 at multivariate analysis (R= 0.62, P < 0.01).
Exercise performance is better preserved with nebivolol than with carvedilol under acute exposure to HA hypoxia in healthy subjects.
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
In a normoxic environment, treatment with β-blockers, either nonselective (such as propranolol [1]) or selective (such as bisoprolol [2], and metoprolol [3]) is known to decrease exercise capacity in healthy subjects. This is chiefly achieved by a reduction in peak heart rate (HR) and cardiac output (CO) [1,2] and in locomotor blood flow [3], both CO and blood flow to the exercising muscles being the main determinants of peak oxygen consumption (VO2) in normoxia [4]. β-blockers may also impair exercise performance by affecting ventilation (VE) control, mitochondrial function, and lung gas diffusion. Although early data report no discernible changes of ventilatory control during exercise in subjects receiving propranolol [5], recent ones suggest that either β1-selective [2] or nonselective β-blockade [6] is associated with a decreased ventilatory response to exercise at any level of VO2 and CO2 production (VCO2). Moreover, as the skeletal muscle predominantly expresses β2-adrenoreceptors (which mediate the mitochondrial activity in the exercising muscle), nonselective β-blockers may impair exercise capacity also by attenuating mitochondrial adaptation to exercise [7]. Finally, β-blockers, especially nonselective ones, may, at least in the case of lung fluid increase, affect exercise performance also by impairing alveolar-capillary membrane diffusion: in fact, over 90% of lung β-adrenoreceptors belong to the β-2 type and are expressed on the alveolar surface, whereas only 10% belong to β-1 type and are expressed on the airways [8].
Acute exposure to high altitude (HA) hypoxia increases minute VE and pulmonary artery pressure (PAP). Moreover, it decreases peak exercise VO2, CO, and HR. Such a decrease is proportional to the decrease of inspired O2 pressure and arterial O2 content [9,10].
To our knowledge, the effects of β-adrenoreceptor inhibition on hypoxic exercise were addressed in healthy subjects in very few investigations in which nonselective β-adrenoreceptor blockade was achieved by means of propranolol only [11–13]. Such studies report that acute exposure to hypoxia decreases exercise performance and that β-sympathetic inhibition by this compound does not further impair maximal O2 uptake despite significantly decreasing peak HR and CO. Taken all together, these studies suggest that, unlike with normoxic exercise, peak HR and peak CO play a minor if any role in preserving exercise performance at HA. Thus other factors, such as changes in VE control, mitochondrial function, lung gas diffusion, and the consequent levels of blood oxygen saturation, might be involved in determining functional capacity during hypoxic exercise at HA. These observations, however, are based on the results obtained by the administration of the first-generation nonselective β-blocker propranolol, only. To our knowledge, no studies have compared the effects of vasodilatory β-blockers, characterized by different cardioselectivity and ancillary properties, on cardiorespiratory responses to HA hypoxic exercise in healthy subjects. In fact, the available evidence comparing the effects of vasodilatory β-adrenergic receptor blockers [14,15] like carvedilol and nebivolol on cardiorespiratory responses to exercise is limited to patients treated with these drugs for chronic heart failure (HF) [16]. The primary objective of this study was thus to fill this gap, and to compare, in healthy subjects, the effects of carvedilol (nonselective) and nebivolol (highly β1-selective) on cardiorespiratory responses to exercise performed under conditions of HA hypoxia.
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
Study Subjects
Out of 35 screened, 27 adult, nonsmoking healthy volunteers taking no medications were recruited by advertisement (15 males, 12 females, mean age 39.1 ± 12.7, range 26–62 years, body weight 66.4 ± 13.3 kg, BMI 22.0 ± 3.3 kg/m2). They were all SL residents not engaged in regular endurance exercise training (Figure 1).
Study Design
On enrollment, at SL, subjects underwent general laboratory investigations, Doppler heart ultrasound, and cardiopulmonary exercise test (CPET), the latter performed for safety and familiarization with the procedure. Subjects were then double-blindly and randomly assigned to placebo (n = 9, one tablet b.i.d.), carvedilol (n = 9, one 25 mg tablet b.i.d.), or nebivolol (n = 9; one 5 mg tablet in the morning, one placebo tablet in the evening). Drugs were taken for 3 weeks before and throughout HA exposure. Three additional CPETs, each one preceded by systolic PAP measurements by echo-Doppler, were performed: under no treatment at SL (CPET 1), under treatment at SL (CPET 2), and under treatment within the first 2 days of HA exposure (CPET 3). As previously described [17,18], all subjects ascended in less than 30 h to the Regina Margherita hut (Monte Rosa, altitude 4559 m), where they did not perform any relevant physical activity before CPET 3. Occurrence and severity of acute mountain sickness was explored by computing in each subject the Lake Louise Score (LLS).
Study Outcomes
Primary endpoint was change in peak exercise VO2 observed between SL under no treatment (CPET 1) and HA exposure under treatment (CPET 3). Additional endpoints were the changes, between the same conditions, in peak exercise VE; the absolute peak values of VO2, VE, HR, and SpO2, achieved in the various study conditions; PAPs values; and LLS at HA.
Cardiopulmonary Exercise Test
All CPETs were performed using the same cyclo-ergometer (Ergometrics 100, Ergoline, Bitz, Germany) and metabolic cart (Oxycon Mobile software v. 4.6, VIASYS Healthcare GmbH, Wurburg, Germany). The exercise protocol included 10 min of monitored sitting rest, followed by 3 min of unloaded pedaling and by 30 W load increments every 2 min up to exhaustion. Breath-by-breath VE, respiratory gases, one-lead ECG, and pulse oxymetry (SpO2) were recorded throughout each test. Arterial blood pressure (BP) was measured with the auscultatory method by a mercury sphygmomanometer in duplicate at the end of the resting phase, at the end of each 30 W step, and at peak exercise.
CPETs were blindly and independently evaluated by two expert readers (D.M., P.A.). The anaerobic threshold was identified by the standard technique [19]. The VE/VCO2 slope was calculated as the slope of the linear relationship between VE and VCO2 measured up to the respiratory compensation point. The experimental protocol was approved by the Ethics Committee of the Istituto Auxologico Italiano. All subjects signed written informed consent.
Echocardiographic and Doppler Study
All echographic-Doppler examinations were performed by the same operators (M.R., G.B.) using a portable device (Vivid I, GE Ultrasound) according to the current guidelines [20].
Lake Louise Score (LLS)
The severity of acute mountain sickness was quantified by the LLS, based on response to a specific questionnaire [21].
Statistical Analysis
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
Normally distributed variables are reported as means ± SD. For all parameters during CPET, mean values were computed over 20 seconds. Differences among groups, changes over time within each group (time effect), and any interaction (differing trends over time among groups) were assessed by two-way repeated measures ANOVA. Post hoc analysis was performed with paired Student's t-test with Bonferroni correction for within-group comparisons; unpaired Student's t-test with Bonferroni correction was performed for between group comparisons. Spearman correlation was used to assess the relationship between peak VO2 and other variables at altitude. Independent predictors of peak VO2 were evaluated by multivariate regression analysis including all variables found to be statistically significant at univariate analysis. Data management and analysis was performed with SPSS version 13.0 (SPSS Inc, Chicago, IL, USA). A P level of < 0.05 was considered statistically significant.
Given the lack of previous data comparing the effects of nonselective and selective β-adrenergic blockers on cardiorespiratory responses to exercise in hypoxia, calculation of sample size was made by means of an "educated guess" of the clinically relevant difference between treatments in changes of peak VO2 from baseline SL to altitude hypoxia (i.e., 5 ± 3 mL/kg/min). With a two-sided 5% significance level, a power of 90%, and equal sized groups, the requested sample size was 8.6 subjects per group. Such a size was also compatible with the demanding conditions of our study at HA.
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
All subjects took the target doses of the investigational drugs over the entire duration of the study. CPETs and PAPs measurements of satisfactory quality were obtained in all but two female subjects randomized to placebo, who were therefore excluded from data analysis. CPET 2 in two other subjects (one male randomized to carvedilol, one female to nebivolol) was not performed because of incident medical problems unrelated to the study (Figure 1). No difference at baseline was observed among treatment groups with respect to gender distribution, age, BP, HR, and anthropometric data as well as PAPs in subjects included in the final analysis. Table 1 summarizes peak CPET data of subjects performing all three tests.
|Placebo N = 7
|Carvedilol N = 8
|Nebivolol N = 8
|Placebo N = 7
|Carvedilol N = 8
|Nebivolol N = 8
|Placebo N = 7
|Carvedilol N = 8
|Nebivolol N = 8
|VO2 (mL/kg/min)
|33.9 ± 10.4
|37.6 ± 4.3
|38.0 ± 8.7
|33.9 ± 9.4
|36.2 ± 3.9
|39.7 ± 8.6
|22.9 ± 8.7a,b
|24.0 ± 4.1a,b
|28.8 ± 5.1a,b
|VCO2 (mL/kg/min)
|39.4 ± 10.8
|44.9 ± 5.7
|46.2 ± 12.1
|40.8 ± 11.7
|45.2 ± 7.9
|49.6 ± 10.2
|26.2 ± 8.6a,b
|28.4 ± 6.3a,b
|35.6 ± 7.2a,b
|1.17 ± 0.06
|1.20 ± 0.05
|1.20 ± 0.15
|1.20 ± 0.06
|1.24 ± 0.11
|1.26 ± 0.10
|1.16 ± 0.09
|1.18 ± 0.09
|1.23 ± 0.07
|VE (l/min)
|93.9 ± 29.1
|90.3 ±21.8
|81.8 ± 24.4
|89.6 ± 22.2
|83.8 ± 25.2
|90.3 ± 19.9
|84.5 ± 27.4
|92.0 ± 20.7
|RR (breaths/min)
|37.8 ± 7.0
|34.7 ± 4.1
|38.2 ± 4.7
|37.0 ± 5.2
|35.9 ± 4.4
|42.1 ± 8.1
|41.3 ± 7.9
|36.5 ± 6.4
|45.9 ± 8.5c
|SpO2 (%)
|96.9 ± 1.3
|97.5 ± 1.8
|98.1 ± 1.9
|97.9 ± 0.7
|97.3 ± 1.0
|97.6 ± 1.4
|79.3 ± 2.8a,b
|75.8 ± 3.0a,b
|75.9 ± 2.0a,b
|HR (beats/min)
|161.0 ± 13.8
|173.4 ± 17.4
|180.4 ± 9.3
|163.9 ± 12.9
|149.0 ±17.3a
|166.8 ± 11.4e
|142.1 ± 21.4c,d
|128.6 ± 22.0a,d
|153.6± 15.5a
|%HR predicted
|92.9 ± 6.4
|94.9 ±7.7
|95.9 ± 5.2
|95.0 ± 4.8
|82.4 ± 11.0@
|89.2 ± 8.6
|82.0 ± 7.6
|70.6 ± 9.7°
|82.0 ± 7.8∧
|O2 pulse (mL/min)
|15.5 ± 4.9
|14.8 ± 4.0
|13.0 ± 4.7
|15.3 ± 4.5
|16.4 ± 3.8
|14.4 ± 4.5
|11.7 ± 3.3a,b
|12.8 ± 3.8b,c
|11.5 ± 3.8c
|SBP (mm Hg)
|199.0 ± 24.0
|183.2 ± 32.0
|177.0 ± 15.0
|185.7 ± 23.0
|175.3 ± 31.6
|163.6 ± 24.3
|182.9 ± 22.9f
|152.3 ± 17.4c,d
|158.8 ± 18.9
|DBP (mm Hg)
|97.4 ± 10.8
|85. 6± 7.3
|87.8 ± 4.5
|94.4 ± 12.4
|83.8 ± 14.1
|79.9 ± 9.2
|99.3 ±8.4c,d
|81.8 ± 10.5
|83.8 ± 7.0
- • CPET 1 (no treatment, SL). All subjects performed a maximal or near-maximal exercise as inferred by the peak respiratory exchange ratio (RER), with results in the normal range and with no differences among treatment groups.
- • CPET 2 (on treatment, SL). None of the treatments at SL had any effect on resting and peak VO2 (Figure 2(A) upper panel), VE (Figure 2(A), mid panel), respiratory rate (RR) (Figure 2(A), lower panel), SpO2 (Figure 3(A), upper panel), peak workload and peak O2 pulse (Table 1). Both β-blockers induced a comparable reduction in resting HR (from 79.3 ± 10.8 to 67.9 ± 8.7 bpm for carvedilol, P < 0.01; from 82.8 ± 12.1 to 67.5 ± 12.9 bpm for nebivolol, P < 0.01) (changes from CPET 1 in Figure 3(A), mid panel). They also similarly decreased peak HR (from 173.4 ± 17.4 to 149.0 ± 17.3 bpm for carvedilol, P < 0.001; from 180.4 ± 9.3 to 166.8 ± 11.4 bpm for nebivolol, P < 0.05) (Figure 3(A), lower panel). There was no significant difference between carvedilol and nebivolol in HR peak as well as in HR reserve (peak exercise-resting HR) at SL. At SL, with carvedilol treatment resting systolic (S) BP and diastolic (D) BP changed from 118 ± 11 to 109 ± 10 mm Hg, P < 0.05, and from 78 ± 8 to 74 ± 11 mm Hg, NS, respectively. With nebivolol, SBP changed from 112 ± 10 to 105 ± 11 mm Hg, NS, and DBP from 75.9 ± 7.1 to 68.1 ± 8.0 mm Hg, P= 0.01. Both SBP and DBP at peak of exercise were not affected by any of the treatments (Table 1).Mean PAPs values did not differ among groups (20.6 ± 2.8, 16.8 ± 2.9, and 19.1 ± 3.9 mm Hg for placebo, carvedilol and nebivolol, respectively).
- • CPET 3 (on treatment, HA). Compared to CPET 1, exposure to hypoxia decreased resting SpO2 (from 98.3 ± 0.8 to 87.3 ± 2.6% for placebo, from 98.4 ± 0.7 to 84.4 ± 4.4% for carvedilol, and from 98.9 ± 0.8 to 84.8 ± 2.7% for nebivolol), and peak exercise workload (Table 1) (P < 0.001 for all), with no difference among treatments. In all groups peak VO2 significantly decreased, compared to both CPETs 1 and 2 (P < 0.01). Reductions in peak VO2 between CPETs 1 and 3 differed among treatments (ANOVA, P < 0.05), being lower with nebivolol (–22.5 ± 8.0%) than with carvedilol (–37.6 ± 8.2%) (P < 0.01 for percent changes, P < 0.05 for absolute changes, Figure 2(B) upper panel). The change with placebo was –32.7 ± 11.0%. Resting VE similarly changed at HA in all groups between CPETs 1 and 3 (from 12.7 ± 3.0 to 14.7 ± 5.0 L/min with placebo; from 12.8 ± 5.1 to 13.5 ± 2.8 L/min with carvedilol; from 13.7 ± 2.1 to 13.7 ± 2.7 L/min with nebivolol). Unlike resting VE, peak VE changes between CPETs 1 and 3 differed among treatments (P < 0.05), being reduced (–9.3 ± 13.3%) with carvedilol, and increased (+15.2 ± 17.1%) with nebivolol (P= 0.05). No significant difference in peak VE changes was observed between placebo (0.7 ± 20.2%) and any of the β-blockers (Figure 2(B), mid panel). Resting RR at HA increased only in the placebo group (P < 0.01 vs. CPET 1, P= 0.01 vs. CPET 2). Peak RR increased at HA only with nebivolol (P < 0.01 vs. CPET 1), such a change being marginally greater than that with carvedilol (P= 0.07) (Figure 2(B), lower panel). Peak SpO2 significantly decreased in CPET 3 compared to CPETs 1 and 2 in all groups, although such a decrease tended to be more pronounced with carvedilol compared to placebo (P= 0.05). Changes in peak SpO2 between CPETs 1 and 3 differed among treatments (P < 0.05), being more pronounced with carvedilol (–22.2 ± 3.7%) than with placebo (–17.6 ± 1.9%, P < 0.05). In the nebivolol group it was –21.2 ± 3.5% (Figure 3(B), upper panel).
The reduction in resting HR observed at SL with carvedilol persisted at HA, while it was less pronounced with nebivolol (P < 0.01 CPET 2 vs. CPET 3). The difference between carvedilol and nebivolol in HR reserve at HA was not statistically significant being 64.0 ± 14.5 bpm for placebo, 55.0 ± 12.4 bpm for carvedilol and 71.7 ± 16.0 bpm for nebivolol. Changes in peak HR between CPETs 1 and 3 differed among treatments (P < 0.01), being significantly higher with carvedilol (–43.9 ± 11.9 beats/min) than with both nebivolol (–24.8 ± 13.6 beats/min) (P < 0.05) and placebo (–18.9 ± 14.9 beats/min) (P < 0.01). No significant difference was observed between placebo and nebivolol (Figure 3(B), lower panel). At CPET 3, HR at peak exercise, reported as percentage of predicted, was lower with carvedilol compared to nebivolol (Table 1).
Resting SBP decreased with carvedilol at SL and did not further change at HA (from 108.9 ± 10.5 to 111.2 ± 7.6 mm Hg). Peak SBP, unaffected by carvedilol at SL, decreased at HA (P < 0.01 vs. both CPETs 1 and 2), such a decrease being larger than that with placebo (P < 0.05). In the nebivolol and in the placebo group both baseline and peak SBP did not change at HA.
The VE/VCO2 slope as well as the VE/VO2 ratio at the anaerobic threshold (Table 2) increased at HA (P < 0.001) with no treatment effect as a result of an increase in VE.
|P (time)
|VE/VCO2 slope
|26.6 ± 2.5
|24.7 ± 2.8
|24.1 ± 3.8
|25.3 ± 1.9
|23.4 ± 3.8
|21.5 ± 2.9
|37.6 ± 4.1a,b
|35.5 ± 4.9a,b
|34.9 ± 4.7a,b
|VE/VCO2 ratio at AT
|30.0 ± 3.5
|29.0 ± 2.6
|29.0 ± 5.4
|30.1 ± 3.0
|29.0 ± 4.7
|29.5 ± 5.1
|43.0 ± 4.21a,b
|40.8 ± 4.3a,b
|40.6 ± 6.4a,b
|VE/VO2 ratio at AT
|27.7 ± 3.7
|27.4 ± 2.5
|28.4 ± 6.6
|28.7 ± 3.4
|27.0 ± 2.9
|26.5 ± 5.0
|41.3 ± 5.4a,b
|38.1 ± 4.1a,b
|39.8 ± 6.5a,b
The decrease in peak VO2 observed at HA correlated in univariate analysis with the decrease in peak VE (r = 0.60, P < 0.01), peak RR (r = 0.51, P < 0.01) and peak HR (r = 0.52, P < 0.01) and with the increase in peak O2 pulse (r =– 0.62, P= 0.001). At multivariate regression analysis, the variation in peak VE (standardized beta = 0.619, P= 0.001) was the only independent predictor of changes in peak VO2 observed from CPET 1 to CPET 3.
Mean PAPs increased at HA (P < 0.01) with no difference among groups (29.7 ± 4.2 for placebo, 27.4 ± 4.6 mm Hg for carvedilol, and 29.3 ± 4.6 mm Hg for nebivolol).
The LLS was equally low in all groups, being 1.6 ± 1.81 on placebo, 3.6 ± 1.81 on carvedilol, and 2.7 ± 2.06 on nebivolol, with a nonsignificant tendency to be worse in subjects randomized to β-blockade.
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
Under acute exposure to HA hypoxia exercise performance is better preserved with nebivolol than with carvedilol, despite similarly increased PAPs and comparable LLS. This represents novel information, our study being the first to compare the effects of different vasodilatory β-blockers on cardiopulmonary exercise testing at an altitude above 4500 m in healthy subjects.
Several studies have demonstrated that exposure to altitude hypoxia decreases peak VO2 proportionally to the decrease of inspired O2 pressure and arterial O2 content [9–13]. Acute exposure to altitude hypoxia stimulates the sympathetic nervous system which, in turn, elicits an increase in resting BP, HR [22], and CO [23,24] and in pulmonary vascular resistances [25]. Most [11,26] but not all of the studies [27] also reported a decrease in peak exercise HR and peak CO [11]. Although tachycardia has been hypothesized as an important mechanism to preserve peak VO2 at HA as in normoxic environment [12], some studies have demonstrated that maximal HR and CO are not the main determinants of peak VO2 at HA [11,12,28]. In a few investigations peak VO2 decreased in healthy subjects exercising in hypoxia but such a change was not affected by nonselective β-adrenergic blockade with propranolol [11–13] despite a significant decrease in peak HR and CO. These results suggest that other factors, such as changes in VE control, pulmonary pressure during exercise, peripheral blood flow, mitochondrial function, lung gas diffusion, and the consequent levels of blood oxygen saturation, affecting O2 delivery and O2 availability at the tissue level, might be involved in determining peak VO2 during hypoxic exercise at HA [28,29].
The results of our study support this suggestion. Since at HA muscle metabolism is even more dependent on O2 availability than at SL, exercise capacity might have been affected by the amount of O2 made available to the mitochondria [29–31]. The greater the VE during exercise, the greater the oxygen flow to the mitochondria and the VO2. When VE becomes unable to maintain arterial HbO2 saturation, reducing the O2 flow to the mitochondria, subjects have to stop exercising. Indeed, at multivariate analysis, the reduction in peak VO2 at HA was independently predicted only by changes in peak VE. Furthermore, despite comparable resting VE among groups in the three testing conditions, in the treatment group with best preserved exercise capacity under hypoxia the best exercise VE was observed. Finally, as the skeletal muscle predominantly expresses β2-adrenoreceptors and as such receptors mediate both the mitochondrial biogenesis and activity triggered by exercise, a nonselective β-blocker like carvedilol might have affected exercise capacity also by attenuating such mitochondrial adaptations [7].
Exercise ventilatory inefficiency, reflected by an increased VE/VCO2 slope, is a typical manifestation of HF, carrying prognostic value [32] independently from VO2, i.e., from CO reduction. Several interventions, including β-blockade, may improve the VE/VCO2 slope in HF patients, in parallel with clinical benefits [33–35], although increases in maximal exercise performance and VO2 are not constantly demonstrated. It has been suggested that the beneficial effect of β-blockade may also depend on an improvement in ventilatory efficiency during exercise [36–38], although a specific comparison between the effects of different β-blockers in this regard is not available. However, whereas a decrease of exercise-induced hyperventilation can be beneficial in normoxia, it may be counterproductive when exercising in hypoxia [6,29]. Although at HA we observed a similar increase in ventilatory inefficiency among treatments, nebivolol-treated subjects showed a better preserved exercise performance (higher peak VO2), which was associated with higher peak VE.
Our data also show, however, that carvedilol administration at HA was associated with a greater decrease in peak HR compared to both nebivolol and placebo. In univariate analysis, the higher peak VO2 observed with nebivolol than with carvedilol was associated with higher peak HR during exercise under HA hypoxia, the relation between peak VO2 and peak HR being however no longer significant at multivariate analysis. This emphasizes importance of the observed association between better exercise performance and achievement of a higher peak exercise VE in subjects receiving nebivolol. Moreover, the differences in exercise performance among groups were neither related to differences in mountain sickness symptoms nor to differences in PAPs. It remains to be determined, however, whether a lower CO at peak of exercise, as inferable from a lower peak HR, might be the cause of a lower VE, VE being flow dependent during exercise [2].
Due to the unique experimental setting, the results of our study may not apply to conditions characterized by longer HA permanence. Experiments were performed in a laboratory inside Capanna Regina Margherita at controlled temperature, a condition not fully representative of outfield at HA, where low temperature, dry air, and UV exposure may further influence exercise capacity. Moreover, to properly assess the different effects of carvedilol and nebivolol on peak exercise HR, administration of different drug doses in different subjects might have been needed. However, in our study we used standard clinical doses of both β-blockers, because, for logistic difficulties, it was not possible in our experimental conditions to individually titrate drug dosages. Thus, the degree of β-adrenergic receptor blockade might have been different in each subject and between drugs. Indeed peak exercise HR was different at HA altitude between carvedilol and nebivolol. Finally, because carvedilol and nebivolol have properties other than beta adrenergic receptor blockade, such as alpha-blocking action for carvedilol and an NO-releasing action for nebivolol, some of the reported effects of these drugs at HA might be related to these specific properties.
In conclusion, our observations show that functional differences during exercise occur under conditions of HA hypoxemia in healthy subjects treated with carvedilol as compared to nebivolol. Our data might also be clinically relevant in selecting the type of β-blocker to be used in cardiac patients, especially if traveling to altitude. Based on our data, nebivolol may be preferred to carvedilol whenever hybobaric hypoxia exposure is expected. This suggestion may also apply at SL, in the case of significant lung diffusion impairment [37,39] secondary to interstitial edema, when preserving β-2 mediated alveolar fluid clearance is crucially important [39].
Conflict of Interest
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
The authors have no conflict of interest.
- Top of page
- Summary
- Introduction
- Methods
- Statistical Analysis
- Results
- Discussion
- Conflict of Interest
- References
- 1The effect of acute vs chronic treatment with beta-adrenoceptor blockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women. Br J Clin Pharmacol1996;41:57–67., , , , , .
- 2Beta-adrenergic blockade and metabochemoreflex contributions to exercise capacity. Med Sci Sports Exerc2008;40:1932–1938., , , et al.
- 3Leg vasoconstriction during dynamic exercise with reduced cardiac output. J Appl Physiol1992;73:1838–1846., , , , .
- 4Point: In health and in normoxic environment, VO2 max is limited primarily by cardiac output and locomotor blood flow. J Appl Physiol2006;100:744–748., .
- 5Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans. J Appl Physiol1983;54:1306–1313., , , , , .
- 6Carvedilol reduces exercise-induced hyperventilation: A benefit in normoxia and a problem with hypoxia. Eur J Heart Fail2006;8:729–735., , , et al.
- 7The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise. J Appl Physiol2009;107:8–16., , .
- 8Respiratory effects of beta-blocker therapy in heart failure. Cardiovasc Drugs Ther2009;23:377–384., , .
- 9Determinant factors of the decrease in aerobic performance in moderate acute hypoxia in women endurance athletes. Respir Physiol Neurobiol2007;159:178–186., , , et al.
- 10Linear relationship between VO2 max and VO2 max decrement during exposure to acute hypoxia. J Appl Physiol1988;64:1486–1492., , .
- 11Beta-adrenergic or parasympathetic inhibition, heart rate and cardiac output during normoxic and acute hypoxic exercise in humans. J Physiol2003;550:605–616., , , , , .
- 12Propranolol does not impair exercise oxygen uptake in normal men at high altitude. J Appl Physiol1986;61:1935–1941., , , et al.
- 13O2 extraction maintains O2 uptake during submaximal exercise with beta-adrenergic blockade at 4,300 m. J Appl Physiol1998;85:1092–1102., , , et al.
- 14The vasodilatory beta-blockers. Curr Hypertens Rep2007;9:269–277., .
- 15Nebivolol: The somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol2009;54:1491–1499., .
- 16Comparative efficacy of nebivolol versus carvedilol on left ventricular function and exercise capacity in patients with nonischemic dilated cardiomyopathy. A 12-month study. Am Heart J2005;150:985.e9–985.e18., , , , , .
- 17Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. Circulation2006;114:1410–1416., , , et al.
- 18on behalf of the HIGHCARE Investigators. Continuous positive airway pressure increases haemoglobin O2 saturation after acute but not prolonged altitude exposure. Eur Heart J2010;31:457–463., , , et al.;
- 19Breathing during exercise. N Engl J Med1978;298:780–785..
- 20American Society of Echocardiography's Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography, European Society of Cardiology. Recommendations for chamber quantification. Eur J Echocardiogr2006;7:79–108., , , et al.;
- 21The Lake Louise AMS Scoring Consensus Committee. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houtson CS, Coates G, editors. Hypoxia and molecular medicine. Burlington , VT : Queen City Printers, 1993;272–274., , , et al.;
- 22Cardiovascular autonomic modulation and activity of carotid baroreceptors at altitude. Clin Sci (Lond)1998;95:565–573., , , et al.
- 23Cardiopulmonary responses of resting man during early exposure to high altitude. J Appl Physiol1967;22:1124–1128., .
- 24Cardiovascular responses in man during exhaustive work at sea level and high altitude. J Appl Physiol1967;23:531–539., , .
- 25Effect of altitude on the heart and the lungs. Circulation2007;116:2191–2202., .
- 26Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol2003;284:R291–R303., , , , , .
- 27Hemodynamic response to work at simulated altitude, 4,000 m. J Appl Physiol1966;21:1589–1594., , .
- 28Role of maximal heart rate and arterial O2 saturation on the decrement of VO2 max in moderate acute hypoxia in trained and untrained men. Int J Sports Med2007;28:186–192., , , , , , .
- 29Ventilation's role in the decline in VO2 max and SaO2 in acute hypoxic exercise. Med Sci Sports Exerc1998;30:195–199., , .
- 30Response of skeletal muscle mitochondria to hypoxia. Exp Physiol2003;88:109–119., , , .
- 31Air to muscle O2 delivery during exercise at altitude. High Alt Med Biol2009;10:123–134., .
- 32Exercise ventilation inefficiency in heart failure: Pathophysiological and clinical significance. Eur Heart J2007;28:673–678., , , .
- 33Carvedilol Prospective Randomized Cumulative Survival Study Group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med2001;344:1651–1658., , , et al.;
- 34SENIORS Investigators. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J2005;26:215–225., , , et al.
- 35MOCHA Investigators. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure.Circulation1996;94:2807–2816., , , et al.
- 36Effects of beta-blocker therapy on ventilatory responses to exercise in patients with heart failure. J Card Fail2005;11:333–339., , , , , , .
- 37Carvedilol reduces the inappropriate increase of ventilation during exercise in heart failure patients. Chest2002;122:2062–2067., , , , .
- 38Effects of beta-blockers on ventilation efficiency in heart failure. Am Heart J2010;159:1067–1073, , , et al.
- 39Lung function with carvedilol and bisoprolol in chronic heart failure: Is beta selectivity relevant?Eur J Heart Fail2007;9:827–833., , , et al.


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When trying to use the WP image editing features I am unable to edit images from posts that were posted during an arbitrary 9 month period in 2008. About 400 posts are effected, no image that was posted during those dates can be modified by WP. For instance, WP is unable to create thumbnails based on these images etc.
Images form before and after the affected time period work fine.
Any help would be greatly appreciated.


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Search: ravensSearch profiles »
ravensfanthecatMatch % Unknown Join to find out!
Ravens, Ravens, Ravens, Ravens, Ravens, Ravens. ... Getting mentally prepared for Sunday's Ravens game. Or in the offseason, watching old Ravens games.
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5 is my paper signed by a crap load of Ravens players that is one of my prized possessions I. ... Im a HUGE Ravens fan...and my junoir year homeroom teacher and I made a bet when the Ravens played the Colts in the first playoff game.
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Would love to catch a Ravens Game at the stadium or at home on tv.
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You stand before a set of doors. One stands tall and solid, Square in shape and pure white in colour. It exudes a sense of peace, and of solidity. Th...
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i'm just kinda making this up as i go, so there's really no specific goal to this test. except that if you take it you're cooler than if you don't.
The Greek Mythology Aptitude Test
I don't ever read these. I suppose I should write one, just in case I'm unusual. Do you know your Greek mythology? You should.
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Build an Airsoft gun target and BB catch to save your walls from destruction and to improve your accuracy.
I gave the kid next door an Airsoft gun for his birthday. Unfortunately, all he did was shoot his mom and dad with it, so I built him this target to keep the peace with the neighbors. Hopefully he remembers this as he gets older (he's only 10) so the little bastard won't steal my vehicle.
First, download PDF template and cut your two side pieces and top and bottom pieces out of 5/8" plywood. Glue together.
Next, cut out the two pieces for the front BB catch. Cut one piece at a 45-degree angle, glue and bradnail (or screw) together and install into the box.
Next, sand all the pieces and paint it whatever color you like. I used paint & laminate left over from my wife's laundry room cabinets. Of course, laminate is optional; it will still work without it. I just have to get rid of this leftover garbage.
When the paint was dry, I applied contact cement on the inside of the target box and back side of the laminate, let dry for 10 minutes and applied the laminate.
Then, I found a nice handle at Habitat for Humanity for only $0.25 (support the homeless). Mark center and apply the handle.


text:
I'd like to build a similar replica of the virtual server I get from my hosting company in order to test a windowless application of firefox using Xvfb.
I'd like to do so using a parallels virtual machine on OSX.
I'm happy to run some commands to get info but I'm pretty much a linux noob so be gentle!
At the moment this is all I really know:
GCC 4.1.2 20080704 (Red Hat 4.1.2-46) on linux2
Thanks :)


text:
Deals & Events
Gramercy Tavern Visits The AviaryBy Sarah Freeman | December 3, 2013 By Sarah Freeman | December 3, 2013
Get a taste of New York's Gramercy Tavern next Monday when the culinary team visits the Aviary to promote their new Gramercy Tavern Cookbook. Chef Michael Anthony will join Grant Achatz to prepare a selection of favorites from the iconic New York restaurant, including roasted beet roll-ups with freekeh, mushroom lasagna, monkey bread and chocolate-covered toffee with pumpkin seeds and sea salt. The evening also includes two drinks selected from the cookbook as well as some signature Aviary cocktails. Tickets cost $135 and include entrance to the event, a signed cookbook and access to all food and drink stations. Guests can select from two seating, one from 6-8 PM and the other from from 9-11 PM. Email firstname.lastname@example.com to reserve a seat.
955 W. Fulton Mkt.; 312-226-0868


text:
Colombian Stocks: Bancolombia, Corficolombiana, Sura, Canacol
The following companies had unusual price changes in Bogota trading. Stock symbols are in parentheses, and prices are as of the market close.
The IGBC Index rose 0.4 percent to 14,149.32, while the Colcap Index increased 0.2 percent to 1,676.44.
Grupo de Inversiones Suramericana SA (PFGRSURA CB), Latin America's largest private pension-fund manager, increased 0.4 percent to 33,140 pesos. Sura said JPMorgan Chase & Co. agreed to pay $178 million for a stake of less than 5 percent in the group's asset management unit, according to a regulatory filing yesterday.
Corp. Financiera Colombiana SA (CORFICOL CB), the financial-services and holding company, fell 0.6 percent to 31,420 pesos. The company said its board approved a plan to bid for as much as 75 percent of Promigas SA shares in circulation, according to a regulatory filing.
Bancolombia SA (PFBCOLO CB), Colombia's biggest lender, advanced 1.1 percent to 27,620 pesos. Bancolombia is not interested in buying Banco Bilbao Vizcaya Argentaria SA's pension assets, Bancolombia CEO Carlos Yepes said today at an event in Cartagena.
Oil producers dropped as crude declined 20 cents to settle at $84.82 a barrel in New York.
Petrominerales Ltd. (PMGC CB), a Calgary-based oil company that operates in the Andean region, fell 2.2 percent to 23,500 pesos. Canacol Energy Ltd. (CNEC CB), the Calgary-based oil company that operates fields in Colombia, dropped 1.3 percent to 1,100 pesos.


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Women's Soccer
Sept. 21, 2003
San Diego CA- Brenna Mullen bended in a corner kick in the 88th minute to allow San Diego a 1-1 tie with visiting Clemson Sunday afternoon at Torero Stadium. Clemson (5-2-1), ranked 13th in the nation by the NSCAA, led throughout after sophomore Alison Graham found the net on a free kick in the fifth minute.
San Diego's record is now 4-1-2 with matches against unbeaten Cal Poly SLO, UC Santa Barbara, winners of four straight, 4-3-1 Arizona, No. 19 Arizona State and No. 3 UCLA on the schedule before West Coast Conference play begins against National runners-up Santa Clara on October 12th.
"This team is capable of achieving a lot," said San Diego head coach Ada Greenwood after Sunday's match. "We really need to capitalize on the offensive end. Ending up with a tie today and not getting a win Friday was not for the lack of offensive chances."
Sixteen Toreros saw playing time on Sunday as San Diego went without the services of leading goal scorer Michelle Rowe throughout the second half. San Diego came away empty on eleven shots in Friday night's 1-0 loss against Kansas. The Toreros put six shots on goal Sunday before Mullen netted the tying goal in the game's waning moments.
Meet the Toreros: Jose Martinez
6'10" freshman forward from Cayey, Puerto Rico.
Meet the Toreros: Frank Ryder
6'10" freshman forward from Boulder, Colo.
2015-16 Highlight Video
All the top plays from 2015-16
Jordan Angus - Male Torero of the Year
Angus reflects on his time at USD
Malina Hood - Female Torero of the Year
Malina Hood looks back at her USD career
NCAA Tournament Preview
San Diego faces Vanderbilt in first round
2016 Celebration of Excellence
Behind the Scenes at the COE
Toreros Participate in Linda Vista Parade
Toreros Participate in Linda Vista Parade
Men's Tennis senior Day
The Toreros host LMU and Pepperdine Saturday and Sunday
Softball WCC Preview
The Toreros host Saint Mary's Saturday and Sunday
2016 San Diego Crew Classic
The Toreros show speed against the nation's top crews
The Torero Baseball Experience
Kris Bryant & Brian Matusz reflect on their time at USD
MBB Senior Night
Jito Kok and Duda Sanadze prepare for the final home game
USD Baseball Season Preview
Season starts at No. 3 Vanderbilt February 19
USD Softball Season Preview
Season starts February 12
UCLA Preview
USD travels to No. 9 UCLA Friday
Toreros Host Kentucky Saturday
USD looks to defend home court against No. 22 Kentucky
Toreros Host Pepperdine & LMU
USD returns home after four-game road trip
Toreros Team Up with PYBL
Men's Basketball hosts annual clinic for Challenged Division
Men's Tennis 2016
USD opens at home vs UC Irvine and UCSD Saturday
BYU Preview
Preview of USD women's basketball WCC opener vs. BYU.
City Championship Highlights
Relive the Toreros' Upset over SDSU at Petco Park
Toreros to Host Hope International
The 9-1 Toreros will host Hope International in their final game before WCC play
Toreros Stun Aztecs at Petco
Postgame reaction and press conferences
Toreros Return Home
USD will host Bethesda before Sunday's City Championship at Petco Park
Men's Basketball Season Tickets
Starting as Low as $99
Butler Preview
Pono Keni and Coach Lindsey talk about Saturday's Senior Day game against Butler
CSUN Preview
Coach Fisher and forward Maya Hood talk about Tuesday's home-opener against CSUN
USC Preview
Coach Smith and Brett Bailey preview the season opener at USC
Davidson Preview
Jonah Hodges and Dale Lindsey talk about Jonah's return and preview Davidson game
San Diego Fall Classic Preview
Coach Dagman previews the San Diego Fall Classic
Nevada Preview
USD's Women's Basketball team will start their season at Nevada this weekend
USD Men's Basketball - The Origins (1955-1973)
A Glance at the Beginnings of Torero Hoops
Campbell Preview
Coach Lindsey and Jeff Starr preview Campbell
Stetson Preview
Coach Lindsey and Jereke Armstrong talk about the season so far
WCC Media Day
Behind the scenes with Men's and Women's Basketball at WCC media day
Warner Recap
Dale Lindsey and Anthony Lawrence on USD's 45-14 win
Warner Preview
Anthony Lawrence and Coach Lindsey preview game vs. Warner
Torero Community Service
USD Athletics helps out at Father Joe's Village in downtown San Diego
Men's Basketball Camp Update
Kok and Carter talk about the upcoming season
Drake Preview
Toreros host Bulldogs for Homecoming game
Dayton Preview
Toreros look for 4th straight win
LMU Preview
Pack the Stadium Night
ITA All-American's Preview
Petronijevic, Angus, & Vittek Prepare
Marist Preview
USD Looks to Extend Home Win Streak
Valparaiso Preview
Toreros First True Road Game of 2015
CSUN and UCSB Preview
Toreros Look to Extend Win Streak
Aztec Invite Recap
Both Squads Finish Second
SDSU Preview
Toreros Take on Cross-town Rival
WNMU Recap
Highlights from 45-21 win
2015 Home Opener
Previewing Western New Mexico
Volleyball Tournament Preview
A preview of the USD Tournament
Men's Soccer Season Opener
Previewing No. 16 Cal
Training Camp Update
Coach Lindsey Recaps the First Two Weeks
2015 WSOC Preview
A brief preview of the 2015 Toreros.


text:
The Coleman 4-in-1 outdoor table is a versatile addition to your patio or garden retreat. It has an easy-fold design with a strong steel body and an aluminum top. This lightweight folding table can be easily carried along to a campsite or picnic spot. Its legs have adjustable knobs for setting the table at 3 different heights. You can also reduce the height of 1 table to create a bi-level serving station. Place the 2 rectangular tables in an end-to-end way for buffet arrangement or pull them together to accommodate 4 people for dining. This portable table resists moisture and is ideal for both indoor and outdoor use.
Features: folds, portable, indoor/outdoor use
Frame Material: Steel
Cover Material: Aluminum
Protective Qualities: Moisture-resistant
Recommended Capacity: 4 People
Maximum Weight Capacity: 1
Care and Cleaning: Wipe Clean with a Damp Cloth
Dimensions: 14.500 H x 31.500 W x 31.500 D
Packed Dimensions: 31.890 L x 3.150 W x 16.540 H
Weight: 20.200
Warranty Description: 1 Year Limited Warranty
Assembly Details: no assembly required
other Info.
Warranty Information
To obtain a copy of the manufacturer's warranty for this item, please call Target Guest Services at 1-800-591-3869.
- Online Item #: 12034407
- Store Item Number (DPCI): 091-07-0012
- Imported


text:
On Second Thought is a one-hour, daily news talk show that airs at 9 a.m. ET weekdays.
Re-examine the shocking story of Leopold and Loeb, who murdered a 14-year-old boy in 1924. Tuesday, July 26 at 7 PM
National Signing Day is over and the reigning AAAAAA Champions, the Colquitt County Packers, had 25 players sign letters of intent on National Signing Day. I had a chance to go one-on-one with Head... MORE
Make your secure online donation at GPB.org.
Wed., October 16, 2013 2:27pm
Criminal Records Get New Scrutiny
A group of Georgia lawmakers is working to overhaul how the state keeps and shares criminal records. "Georgia has one of the, in my opinion, most antiquated laws relating to record restriction of criminal records in the country," said state Senator Joshua McKoon (R-Columbus).
Full Story
Tue., August 21, 2012 3:38am
McKoon: Balfour Fine Too Weak
Joshua McKoon, a Columbus Republican, said Monday that the $5,000 fine that Don Balfour negotiated with the Ethics Committee last week is insufficient. McKoon, the lone member to vote against the settlement, filed a minority report with the Senate.
Fri., March 9, 2012 9:44am
Ethics Bill: Dead But Not Forgotten
One of the bills that didn't survive the "crossover day deadline" at the Capitol, was an ethics bill to cap lobbyist spending. Senator McKoon, who helmed the bill has promised to work toward new ethics legislation for the next session.


text:
I'm experimenting with variable arguments in C++, using va_args. The idea is useful, and is indeed something I've used a lot in C# via the params functionality. One thing that frustrates me is the following excerpt regarding va_args, above:
Notice also that va_arg does not determine either whether the retrieved argument is the last argument passed to the function (or even if it is an element past the end of that list).
I find it hard to believe that there is no way to programmatically determine the number of variable arguments passed to the function from within that function itself. I would like to perform something like the following:
void fcn(int arg1 ...)
va_list argList;
va_start(argList, arg1);
int numRemainingParams = //function that returns number of remaining parameters
for (int i=0; i<numRemainingParams; ++i)
//do stuff with params
To reiterate, the documentation above suggests that va_arg doesn't determine whether the retrieved arg is the last in the list. But I feel this information must be accessible in some manner.
Is there a standard way of achieving this?


text:
COLUMBIA, S.C. (AP) -- No. 10 South Carolina hopes to follow in
Auburn's footsteps from a year ago -- along with gaining a bit of
payback for last season.
The Gamecocks (4-0, 2-0 SEC) lost twice to the Tigers (3-1,
1-0), including 56-17 in the Southeastern Conference title game.
Auburn was a work in progress through the early part of 2010,
needing several escapes to make its national title run.
This time around, it is South Carolina walking the tightrope,
squeaking by in nearly all its wins as it tries to energize an
offense that's struggling to score points.
The Gamecocks are 99th nationally in passing, despite having
fifth-year quarterback Stephen Garcia and receiving star Alshon
Jeffery. Their success so far has come from Marcus Lattimiore, the
SEC's top rusher with 611 yards.
(Copyright 2011 by The Associated Press. All Rights Reserved.)