text:
Deviled Potato Salad
Total Time
Prep 10 mins
Cook 10 mins
This is an awesome potato salad recipe with lots of flavor and a great kick from hot sauce!
Ingredients Nutrition
- 2 1⁄2 lbs all purpose potatoes, peeled and diced
- salt
- 1⁄4 medium onion, grated
- 3 tablespoons mustard
- 1⁄2 cup mayonnaise
- 1 teaspoon sweet paprika
- 1 teaspoon hot cayenne pepper sauce (like Tabasco or Franks)
- salt and pepper
- 2 scallions, thinly sliced
- Boil the potatoes in water seasoned with some salt, until they're tender.
- Drain the potatoes and let them cool a bit.
- In a medium bowl add the onion, mustard, mayonnaise, paprika and hot sauce.
- Stir to combine, add potatoes and toss to coat.
- Season with salt and pepper to taste.
- Top with the chopped scallions and a sprinkling of paprika.
Most Helpful
Very yummy! I used creole mustard in mine as well as using cajun spice and adding some hard cooked egg (my preference). Was a little spicy with the Tabasco flavor coming through but we really loved it! Made by Saucy Senorita for ZWT5
Very very yummy potato salad!! Easy to put together. I used finely chopped onion instead of grated and threw in a couple of hard boiled eggs and crumbled bacon. Thanks for sharing!! Made for Las Mistico Magicos Sirenas - ZWT5.
Spring PAC 20009: OUTSTANDING potato salad - wow!!


text:
I tried a few 'thermometer' plugins but this was the only one that was easy to format size, show target and amount raised. Using Graphene theme.
The graphical display of olimometer is okay. It works for displaying the actual amount. Installation had no complications and worked instantly after having added the paypal API information.
I tested Olimometer on a local test environment (InstantWP) where Olimometer caught the total of the paypal account MINUS paypal fee. there was a donation about 5 EUR and Olimometer displayed EUR 4,55.
In productive installation Olimometer got the total donation of EUR 5...
Wait there was one complication:
In productive installation Olimometer told me that I did not have enough rights to create a new Olimometer... :/ I used the default Olimometer which is enough for now.
I have Multi site installation.
Thanks for this helpful plugin!!
You must log in to submit a review. You can also log in or register using the form near the top of this page.

subset: commoncrawl


text:
Fear not! Citywide ferry program will be ready to set sail
Worries that the city's expansion of waterborne commuting are misplaced, administration says Read More
Worries that the city's expansion of waterborne commuting are misplaced, administration says Read More
Since Sandy, New York has focused on resilience, not subsidizing people to live in flood zones
Oxford Nursing Home wants to build a facility in Red Hook, but Councilman Carlos Menchaca said the area is not ideal because it's prone to floods
The 72-year-old Manhattan Democrat was convicted last year in a $5 million corruption case
American Copper Buildings, a rental tower being built by JDS Development, will also be storm-proof
The city plans to unveil plans to remake Edgemere, a working-class community on the Rockaway Peninsula
Money comes from $50 million from the Lower Manhattan Development Corporation's legal settlement with a construction company
The contingency plan will only be able to accommodate a fraction of the 100,000 commuters that use the rails
Union coalition SMART says it hasn't seen any plans or been asked for input on how to wind down service
Readers respond to mall subsidies and bias
State funding for Empire Outlets will help the borough recover from Superstorm Sandy and withstand future weather events
AECOM, along with Dewberry, are the winners of a request for proposals to design a resiliency system
More than 100,000 coats were received, the most since Superstorm Sandy
The New York senator appeared with Cory Booker at an event to discuss the project
Opposition to government mandates doesn't apply when our city stands to end up under water
The new 34th Street-Hudson Yards station required a supply of fare-collection gates the city didn't have after Superstorm Sandy destroyed their spares
As the bistate agency seeks a new head, its Executive Director Patrick Foye decides to leave.
The de Blasio and Cuomo administrations have teamed up to help entrepreneurs prepare physically and fiscally for severe weather.
Tax revenues are running slightly ahead of projections, and the surplus will be spent on shelters, Rikers and next year's expenses, Bill de Blasio said Thursday.
The Federal Emergency Management Agency has found that roughly three out of five of the 17,000 policyholders eligible for the review should have been awarded money, three years after the storm.
Can't find the information you need? Try searching for it!
Sign up for our FREE daily email newsletter. A summary of the day's top business and political headlines from the newsroom of Crain's New York Business.


text:
ODT Online
ODT /directory
St Joseph's Cathedral School gave buckets filled with joy to
St Leonards School yesterday.
After the recent deaths of Ellen (6) and Bradley (9)
Livingstone, who attended St Leonards School, St Joseph's
wanted to do something to bring smiles back to the faces of
the St Leonards pupils.
St Joseph's organised a bake sale and raised $230 to buy the
Bucket Filler of the Week Cup for the grieving school.
St Leonards principal Jo Wilson said the cup would be
presented weekly to the pupil who ''filled the buckets'' of
their peers through kind deeds.
St Joseph's gesture - which showed ''that everybody ... is
still thinking of us'' - was a ''lovely thought'', she said.
St Joseph's Cathedral School pupil Ollie McKewen (10) said
his school wanted ''to make sure other communities know we
are behind them''.
''If any disaster hits, we are there to help them,'' he said.
Four pupils presented the cup to the school. They said they
were pleased to support their peers during a difficult time.
Mrs Wilson said the school community was healing and had
taken a train trip on Saturday from the funds raised by an
auction organised by school alumni.
The support of the wider community had ''been amazing and
hasn't ... stopped'', she said.
A name, residential address, and (preferably residential) telephone number is required from readers who comment on ODT Online. These details will not be visible to site visitors.
Login or Register
to add your business to the ODT/directory. Quick link to
Submit your news & photos - Login or
Opinion? Have your say - Login or Register
Submit your
event or notice
Add a photo
Bookmark ODT
Make ODT my
Otago Daily Times print and digital edition, The
Star - Dunedin, The News - Central Otago, The
Ensign - Gore, Southland Express -
Invercargill, Southern Rural Life - Otago and
Southland, The Courier - Timaru, Courier Country - Canterbury and
West Coast, Queenstown Times - Queenstown, Mountain Scene -
Queenstown, The Oamaru Mail - Oamaru, The
Greymouth Star - Greymouth, Hokitika Guardian - Hokitika,
West Coast Messenger - West Coast, The Ashburton Courier -
Ashburton, The News - North Canterbury, Extra! schools
publication, Property
Times South Canterbury


text:
Spidey and the Black Cat by DESPOPWatch
Felicia's the only girl for him as far as I'm concerned.
Awww, poor Peter Parker. What a conundrum...who to choose? The insanely hot and intelligent supermodel or the insanely hot jewel thief with a cat fetish and "adventurous" in expressing her affections for you.
Jerk. Quit whining Peter. Some of us can't get a date at ALL!
Jerk. Quit whining Peter. Some of us can't get a date at ALL!
very 60's like, well done
Beautiful pic, Despop !!!
Ohh....that's cool.
Beautiful. Quite possibly my favorite alternative to primary couple.
wow nice!
Very good pic here.


text:
When director Matthew Vaughn presented scenes from his upcoming film, âKick Ass,â at Comic-Con International this year, itâs true to say the movie really lived up to its name. The clips were given a standing ovation, and the seven thousand-plus fans in the audience demanded that the footage be shown again.
âKick-Assâ is based on the popular Icon Comics series created by superstar writer Mark Millar and legendary artist John Romita Jr., about an ordinary teenager with no superpowers who decides to put on a costume and fight crime. The movie, which was made by Vaughn with no studio backing, was recently picked up by Lionsgate and will be released sometime next year. âKick-Assâ stars Aaron Johnson as David Lizewski (a.k.a. Kick-Ass) and features Christopher Mintz-Plasse (âSuperbadâ) as his sidekick, The Red Mist; Nicolas Cage (âGhost Riderâ) as Big Daddy; and Chloe Moretz (âThe Amityville Horrorâ) as the deadly Hit-Girl.
Vaughn is no stranger to comic book films, having directed the live-action adaptation of Neil Gaimanâs âStardust,â which he co-wrote with âKick-Assâ screenwriter Jane Goldman.
CBR News had the opportunity to sit down with Vaughn and Goldman at last monthâs Comic-Con International in San Diego. The two spoke honestly about âKick-Ass,â collaborating with Mark Millar, what itâs like to make a movie without a studioâs assistance, the future of comic book films, and when fans might be able to read the final issues of the comic book.
CBR: Matthew, you made âKick-Assâ without any outside financial backing. How did you pull that off?
MATTHEW VAUGHN: I keep a few things under my mattress. No, I raised the money. Every studio turned it down and that really pissed me off. Iâm like, âGuys, this is a really good script and its going to make a good film.â They werenât interested. I had the same experience when I was producing âLock, Stock and Two Smoking Barrels.â Everybody said no and that they werenât interested. So I said, you know what, Iâm going to try it again.
We made this for probably half the money a studio would have made this for. Which is good, though, because it makes you think out of the box. There are a lot of things I wanted to do which we couldnât afford and then you come up with better ideas and how to actually execute it. Iâm lucky enough that Iâve made a lot of money so I donât have to work anymore. âLock, Stock and Two Smoking Barrelsâ and âSnatchâ made us enough money that I am in a privileged position so that I can choose what is right for me.
I think that making a movie has got to be a labor of love. Every film Iâve done has been and I think thatâs why theyâve been successful, because I did it because I wanted to make the film and not because I wanted to make money doing it. I wanted to make money but that wasnât my driving [motivation]. Iâll do this for free! I did do it for free!
What was the genesis of the âKick-Assâ film? Were you writing the script while Mark Millar was writing the comic book?
MV: Yes. We wrote the script and the comic at the same time so it was a very sort of collaborative, organic process. I met him at the premiere of âStardust.â We got on really well. I knew who he was and what he had done but I didnât know him. He pitched me the idea. I said, âThatâs great!â He then wrote a synopsis. I went, âThatâs great, letâs go do it now! You write the comic, Iâll write the script.â And we just kept in contact and we got it done. Heâll probably say something absolutely different but that is the truth.
Jane, is it difficult adapting another writerâs work, as apposed to writing something completely original?
JANE GOLDMAN: No, I love working on adaptations. It was a really interesting challenge and it was something I really loved doing. This was a unique one because Mark hadnât finished it when we started, but he was unbelievably generous as long as we didnât kill off anyone he wanted to write into the next volume. He was incredibly collaborative and Iâm so grateful for that. But obviously it was awesome because the guyâs a legend.
Itâs unusual for a film to be in production before the first arc of the book is fully released. Will the final issues of âKick-Assâ be published before the film is out?
JG: Yeah, I think itâs mainly two issues left but it may possibly be after [the film comes out] because John Romita, Jr. has been working on the animated sequence that has been taking up a lot of his time. Markâs done, obviously, but yeah, the comicâs not out yet.
Are there and major differences between the end of the screenplay and the end of the first arc of the comic book?
JG: I havenât seen the last issue but as I gather from Mark, itâs pretty close.
Matthew, as a director, your name has been thrown around a lot of comic book properties over the years. âX-Men: The Last Standâ and âThor,â for example, and obviously âStardustâ and now this. How do you feel about the comic book medium and what attracts you to it?
MV: I like comic books. I knew I wanted to make movies that I wanted to go watch and Iâve always loved superhero comic book movies. So, you arenât going to see me doing âSchindlerâs Listâ or something like that.
What are some of your favorite comic book movies?
MV: Iâve got to say Tim Burtonâs âBatmanâ totally transformed the way I looked at [comic book movies]. The original âSupermanâ Recently I liked âIron Manâ a lot. I really liked âThe Dark Knight.â I really thought âThe Dark Knightâ was good. Thereâs a lot of crap Iâve had to watch as well.
Do you feel that Hollywood is over saturating the superhero genre, that the bubble is going to burst on comic book movies or do you think that comic book films are here to stay?
MV: I think comic book movies are, but remember âRoad to Perditionâ was a comic book movie so thereâs a wide genre. I think the superhero films that Hollywood has been churning out have had their day and I think âIron Man,â âThe Dark Knight,â âWatchmenâ and now âKick-Assâ are moving it away from, âHey, Iâm a superhero. Iâm going to save the world, and ⦠some Hollywood crap.â I think the genre is changing and it has to change. The studios will either realize that and if they donât then there wonât be comic book movies because they havenât adapted to what the audience wants.
âKick-Assâ hits theatres in 2010.


text: I'm making a news site at http://www.thenewscrave.com and I want when the user clicks on any given category, it lists all the posts (title only) from that category instead of just going to the most recent story and having a 'next post' link on the bottom. can anyone give me some pointers? :)


text:
We're just three weeks away from the season premiere of Agents of SHIELD season two, and Marvel have kept things mighty quiet. Until now, that is. Finally, we get our first look at new footage from Agents of SHIELD in this brief teaser.
The trailer shows a more back-to-basics approach for the team. While the SHIELD of the Marvel Cinematic Universe has always been a force that operates relatively out in the open, that isn't always how it was in the comics. They're supposed to be secret agents, right? It looks like we'll see more of that this year.
Watch it here:
Agents of SHIELD season two premieres on Tuesday, September 23rd in its new time of 9 pm.
Like us on Facebook and follow us on Twitter for all news updates related to the world of geek. And Google+, if that's your thing!


text:
"Rather than fire people, we got together as a group and said we're going to be all in this together and keep it going," Tufts recalled. "It was a watershed moment for our company, and we were ready for the rebound. Unfortunately, the rebound has yet to come."
There have been few hires in the past two years, and no salary increases. This summer, he gave employees every other Friday off.
He said Obama "came on strong," because he had to.
"He said he's going to take it to the public," Tufts said. "I think he made his case very well that sometimes you have to spend money to make money. ... The logjam needs to be broken."
Others reveled in Obama's tough talk. "My immediate reaction is 'Wow! That's the guy I voted for,'" said Erik Berg, 43, who teaches at the John D. Philbrick Elementary School in Boston's Roslindale neighborhood. "Where's he been for the last 2 1/2 years?"
He particularly liked Obama's dig at members of Congress who've pledged never to vote for a tax hike on the wealthy.
"I don't know how our country has come to a point where we cuddle billionaires and we vilify working people, particularly public sector workers," he said.
Lincoln Newey, of Utah's Salt Lake Valley, said he liked the way Obama "took it to the tea party." Laid off in early 2009 by the limousine company he managed, the 49-year-old MBA with two decades of marketing and communications experience feels lucky to have a part-time job providing financial advice to seniors.
"It's an hourly wage, but it's the best hourly wage I've seen in a while," he said.
The way Newey sees it, nothing short of a "man on the moon" plan that ignores the clamor for reduced federal spending will shake the economy out of the doldrums.
Joe Olivo, though, was not impressed by the president's proposals. The owner of Perfect Printing in Moorestown, N.J., has had a good year so far. Revenue has grown 20 percent, back up to pre-recession levels. But he's still skittish from 2008, when revenue plunged 25 percent in a single month — the worst drop since he opened shop in 1979.
Olivo has 45 employees and could use a few more. But he's wary of reaching that magic payroll of 50, at which point health care reforms would mandate he provide employee health insurance or pay a fee beginning in 2014.
"That is a huge cloud," said Olivo, who has gotten by with temporary workers and has postponed buying new equipment. He said the president's proposals — such as the tax credit for hiring veterans — show he doesn't understand small business.
"They don't have the time or resources to file the paperwork to get those credits," he said. "There was nothing (in the speech) to convince me, 'Start investing again.'"
Back in Durham, Wilma Dillard swung by the restaurant Thursday to check on things, just as she does every few days. She's still paying the utilities, waiting — and hoping.
On a wall in the silent banquet room out back, the nation's first black president stares out from a framed, enlarged copy of an Ebony magazine cover. "IN OUR LIFETIME," the headline declares.
"This country cannot go down the tube — I just don't think it will," she said. "But we've got to come together. We've got to have unity. The parties have to come together and WORK together as one. This hand cannot fight this hand and expect for the body to be whole."
Associated Press writers Johanna Kaiser in Boston; Errin Haines in Atlanta; Ken Kusmer in Indianapolis; Christine Armario in Miami; Chris Rugaber in Washington, D.C.; Tom Coyne in South Bend, Ind.; Haven Daley in Redwood City, Calif.; Josh Loftin in Salt Lake City; and Deepti Hajela in New York also contributed to this report.
- Penny-farthing owner keeps on riding
- Authorities: Munich shooter planned attack...
- Clinton's turn: Guide to the Democratic...
- Baton Rouge to continue to mourn officers...
- Civil-rights marchers: US still needs to...
- Obama: Trump's NATO comments show...
- Turkey investigating people who say coup...
- Author, activist speaks at Theodore Roosevelt...
- Sarah Silverman: Bernie-or-bust Dems... 49
- Is Bernie Sanders an atheist? 44
- Trump says Russia should find Clinton's... 43
- Obama boosts Clinton: Carry her like... 41
- If Mitt Romney endorsed Gary Johnson,... 38
- Clinton wins historic nomination,... 37
- After turmoil, Sanders, Michelle Obama,... 31
- Dems' division, emails roil party on... 28


text:
Ingrown Toenail Index
Featured: Ingrown Toenail (Onychocryptosis) Main Article
Ingrown toenails are caused by the growth of the toenail into the surrounding nail fold. Symptoms and signs include toe pain, swelling, redness, and yellow drainage. Treatment at home involves soaking the affected foot in diluted white vinegar or Epsom salts, elevating the foot, and trimming the nails straight across. Surgery is also an option for severe cases. Prevent ingrown toenails by wearing shoes with a wider toe box and avoiding repeated injury to the toenails. Avoid curving or cutting the nails short at the edges.
Patient Discussions - Viewers share their comments
Local Resources - Find a local Doctor in your town
Pictures, Images, Illustrations & Quizzes
Related Diseases & Conditions
View All 13 Ingrown Toenail Related Diseases & Conditions »
Related FAQs, Doctor's & Expert's Views
Health News
View All 14 Ingrown Toenail Health News »
Health Features
Tools & References
View All 8 Ingrown Toenail References »


text:
Hello Dribbble, I finally made it! I just turned 18 years old and I am honored to join this community. This is my first shot of a cross of the Kiwi bird and the fruit.
Please feel free to comment, criticize, give me tips and tricks and anything else that can help me improve :)
Check the @2x
Thank you @Sherman Jackson for the Invite!
keyboard shortcuts:
L or F like
Z toggle zoom
post comment
Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
Copyright © 2009–2016 Dribbble LLC. All screenshots © their respective owners. Shipped from Salem, Mass. USA.


text:
"The Beauty Of Angkor Wat" Angkor Wat by elainetan7906
Angkor Wat Travel Guide: 1,708 reviews and 5,003 photos
Angkor Wat is a temple at Angkor, Cambodia, built for King Suryavarman II in the early 12th century. Angkor Wat is the most important monument of the Khmer civilization and the largest temple in the world.
The View is magnificient.
Angkor Wat is surrounded by a moat and an exterior wall measuring1300 meters x 1500 meters. The temple itself is 1km square and consists of three levels summounted by a central tower. Nearly 2000 distictiely redered apsara varvings adorn the walls throughout the temple.
The famous Steepest Steps are closed for climbing. So sad..... I will want to try it...
Reviews (16)
After watching the sunrise, we walked toword the back of Angkor Wat - North Gate if not mistaken... Along the way, we... more travel advice
There are many people waiting for the sunrise early in the morning. We wake up 4.30am, and get ready to take off from... more travel advice
the orange colour Sunrise appear after awhile... more travel advice
This is the frist glimpse of Angkor Wat when we re-visit Angkor Wat on the second day morning for the sunrise.. Many... more travel advice
elainetan7906's Related Pages
Angkor Wat Travel Guide
Member Travel Pages
- "Angkor Wat"
- "Angkor Wat Rediscovered"
- "Angkor"
- "Angkor What?"
- "Facing to the west and stairway to heaven"
- "Angkor Wat: Our Own Personal Tuk Tuk"
- "Angkor Wat"
- See All...
- Things to Do in Angkor Wat
- Hotels in Angkor Wat
- Transportation in Angkor Wat
- Nightlife in Angkor Wat
- Restaurants in Angkor Wat
- Shopping in Angkor Wat
- Warnings and Dangers in Angkor Wat
- See All...
"Go with your feeling & just be yourself!"
- Member Rank:
- 0 2 5 0 6
- 196 Reviews
- 884 Photos
- Add Friend
- Follow
- Send Message
Badges & Stats in Angkor Wat
- 16 Reviews
- 19 Photos
- 0 Forum posts
- 0 Comments
- 186PageViews
- See All Stats
- See All Badges (6)
Have you been to Angkor Wat?Share Your Travels
Latest Activity in Angkor Wat
- updated a Angkor Wat Travel Page "The Beauty Of Angkor Wat"
- Wrote a Review Angkor Wat - The North Gate in Angkor Wat Things to Do
- Uploaded a Photo to "Angkor Wat - The North Gate"
- Posted in Travel Pulau Pangkor Forum "Pulau Pangkor"
Photos in Angkor WatSee All Photos (19)
Top 10 Pages
- Bali Intro, 23 reviews, 95 photos, 3 travelogues
- Taipei Intro, 27 reviews, 66 photos
- Melaka Intro, 18 reviews, 56 photos, 1 travelogue
- Kuala Lumpur Intro, 12 reviews, 51 photos, 3 travelogues
- Khett Siem Reab Intro, 22 reviews, 39 photos, 1 travelogue
- Angkor Thum Intro, 22 reviews, 25 photos
- Karangasem Intro, 1 review, 45 photos, 5 travelogues
- Beijing Intro, 3 reviews, 42 photos, 4 travelogues
- Pulau Dayang Intro, 1 review, 44 photos, 5 travelogues
- Pulau Tioman Intro, 8 reviews, 31 photos, 3 travelogues


text:
Try Prime
All Departments
Amazon Warehouse Deals
Apps & Games
Clothing & Accessories
Gift Cards
Grocery & Gourmet Food
Health & Personal Care
Home & Kitchen
Industrial & Scientific
Kindle Store
Livres en français
Luggage & Bags
Luxury Beauty
Movies & TV
Musical Instruments, Stage & Studio
Office Products
Patio, Lawn & Garden
Pet Supplies
Shoes & Handbags
Sports & Outdoors
Tools & Home Improvement
Toys & Games
Video Games
Shop by
Hello. Sign in
Your Account
Your Store
Deals Store
Gift Cards
en français
Today's Deals
Outlet Deals
Warehouse Deals
eBook Deals
Subscribe & Save
The Dream & the Nightmare: The Sixties' Legacy to the Underclass
Customer Reviews
Customer Reviews
3.7 out of 5 stars
3.7 out of 5 stars
5 star
4 star
3 star
2 star
1 star
The Dream & the Nightmare: The Sixties' Legacy to the Underclass
Mryon Magnet
Format: Paperback
+ Free shipping with Amazon Prime
Your rating
Rate this item
Your rating
Write a review
Add to Cart
Add to Wish List
Top positive review
See all 9 positive reviews
5.0 out of 5 stars
I can feel it coming in the edge of night, oh lord!
Eugene A Jewett
on June 13, 2002
Myron Magnet, publisher of the quarterly "City Journal", has written an absolutely wonderful book about the best laid plans of mice and men going awry. In this book the aspirations of the socialist central planners are shown to create more problems than they solve hence the title.
Magnet is a skillful writer and a deep and intricate thinker. While his observations are absolutely correct, his depictions of the carnage wrought are gentle and rancorless. To draw a contrast, Martin Gross, the equally intelligent author of the "the End of Sanity: Social and Cultural Madness in America", is far more trenchent and bitter in his denunciations of the same problems that Magnet describres.
Magnet's thesis is that the Socialist Left's embrace of Marxist as well as Freudian theory has accrued to poltical and social policies which have been incredibly destructive to the culture of the have-not's in America. When one considers that the Left has controlled the political process for the most of the last half century one cannot help but wonder what it takes for bad societal outcomes to stop bad social policies? Indeed the record is clear and the jury is in, Socialism is a loser. Even Western Europe is moving inexorably toword the Center-Right in election after election. Keynes is out and Hayek is in. The 3rd way is not the way.
Magnet goes through the underpinnings of Marxist theory and the intricate arguments of its more intellectual proponents. It never ceases to amaze how intelligent people can concoct such detailed and seemingly logical arguments to support such blatently sophist conclusions, but Magnet patiently weaves together his fabric of stories, facts and conclusions until you cannot resist agreeing with his solutions and his remedies.
The theories of both Freud and Marx, as depicted in this book, are on the outside looking in at this point in history, but a fierce rear guard action is still being fought by the true believers in academia, Hollywood, the major media and the major book publishers. In this book Magnet shows them the way to redemption. When will they listen?
To those of us willing to acknowledge the turning of the wheel of history, Magnet does a marvelous job in helping us transition from the old to the new. This book is purportedly the most important book read by "W" other than the bible, and it is said to form the basis for his stance as a compassionate conservative. It should be read by everyone seeking to understand how we got here and where we're going to go.
Read more
Top critical review
See all 6 critical reviews
2.0 out of 5 stars
Why ignore the facts?
A customer
on September 20, 2002
I find there is good reason for concern and even a taint of fear as this intent to polarize the situation regarding America's underclass persists despite historical fact revealing the "true" reasons the world is what it is today. The rise of the nation-state and the profit-seeking joint-stock companies under mercantilism largely, but partially, describe the rise of the world we see today. I am not a liberal, but to pin the entire blame of America's underclass struggles on leftist ideology is to severely and overtly miss the mark by ignoring hard historical fact. This confirms individuals' tendency to expose themselves to that which confirms their beliefs. The subject must be viewed holistically and not from a narrow political critique for sound and honest conclusions to be drawn. This book fails to do so.
The "developing" world has been left with the burden of cleaning up the aftermath of colonialism and we dare say retribution and a sincere effort to lift those who were stepped on in the process is not necessary? Puerto Ricans and blacks, for example, never voluntarily chose to become part of America. Blacks were enslaved by the millions thus impoverishing their origins and we dare say we don't owe the black community anything? Blacks were officially marginalized in America. The intent to intellectually and inhumanely argue away the harm that has been done is to ignore the existence of the scar that has been left in American society and the ethnocentrism and racialism that dominates mainstream American culture that has stymied the life chances of the majority of the so-called "underclass."
I believe in personal responsibility, but I have witnessed in America, and abroad, the harsh realities many people (including indigenous peoples) are subjected to in severely stratified societies where elitism is the rule and pluralism, although highly applauded in state constitutions, is the exception.
I suggest you read this book with an open and critical mind. That you research and lay out a dichotomy of facts before you and then let the truth gravitate you towards an honest conclusion.
Read more
Sort by:
Most recent
Filter by:
All reviewers
Verified purchase only
All reviewers
All stars
5 star only
4 star only
3 star only
2 star only
1 star only
All positive
All critical
1 star only
All formats
Format: Paperback
All formats
There was a problem filtering reviews right now. Please try again later.
Showing 1-2 of 2 reviews
(1 star).
Show all reviews
1.0 out of 5 stars
What A Shame!
A customer
on February 19, 2003
Format: Paperback
Hearing that political guru Karl Rove gives a copy of this book to White House visitors, I decided to buy a copy and read it. I was disappointed to find an long winded diatribe, constantly whining about the Great Society, and blaming the social programs of the sixties for the problems of today. Mr Magnet misses the mark by several country miles.
Was this review helpful to you?
Report abuse
Please write at least one word
You must purchase at least one item from Amazon to post a comment
A problem occurred while submitting your comment. Please try again later.
Sign in and comment
Sort by:
There was a problem loading comments right now. Please try again later.
1.0 out of 5 stars
Just what conservatives are looking for
Donald Detrich
on August 10, 2003
Format: Paperback
This book is well worth reading. In it you can witness first hand the twisted statistics and warped rationalizations necessary to justify the worsening disparity between the lives of most of our nation's citizens, and the mega-wealthy who run things. You can learn how poor people are just too stupid, lazy and morally depraved to overcome the corrupting good intentions of misguided liberals. Learn how to blame Dr. Spock, rock 'n' roll and those permissive liberals for all our problems. It may sound like a perfect rehash of Spiro Agnew circa 1968, but so what. Of course the punch line is, if we just discontinue funding programs that benefit poor people, so their lives are even more of a living hell than they already are, then they will surely get the message and be happy to work hard for minimum wage and quit all this whining about opportunity. This popular and pathetic argument is just the rationalization that the newly conservative and greedy need to justify supporting a system that systematically thwarts the aspirations of the poor and middle class, while ignoring the vast expense of corporate corruption. Just forget about statistics that clearly show the mega wealthy who run this country are getting richer, faster than ever before, while the poor and middle class are steadily loosing ground.
Its certainly heartening to hear that this book is being championed by our president, son of a diplomat and past president, pushed through Harvard as a "C" student, who made every dime of his millions through family business connections, never worked a "real job" in his life, and happily mined his dads political connections to become our appointed president. Gee, I guess maybe wealth does have its advantages.
I sincerely hope that poor and middle class people find the necessary courage to overcome the odds that have been stack against them. I also sincerely hope that the wealthy find the necessary courage to admit their complicity in the multi-billion dollar corruption that pervades or business and political community, which continues to thwart the aspirations of the rest of their fellow citizens.
Was this review helpful to you?
Report abuse
Please write at least one word
You must purchase at least one item from Amazon to post a comment
A problem occurred while submitting your comment. Please try again later.
Sign in and comment
Sort by:
There was a problem loading comments right now. Please try again later.
See all details for The Dream & the Nightmare: The Sixties' Legacy to the Underclass
Unlimited FREE Two-Day Shipping, no minimum threshold and more.
Prime members enjoy FREE Two-Day Shipping on millions of eligible items with no minimum threshold.
Get started
Back to top
Get to Know Us
Amazon and Our Planet
Investor Relations
Press Releases
Make Money with Us
Sell on Amazon
Amazon Associates
Advertise Your Products
Independently Publish with Us
Amazon Payment Products
Amazon.ca Rewards Visa Card
Credit Card Marketplace
Reload Your Balance
Amazon Currency Converter
Let Us Help You
Shipping Rates & Policies
Amazon Prime
Returns Are Easy
Manage your Content and Devices
Customer Service
United Kingdom
United States
Amazon Web Services
Scalable Cloud
Computing Services
Book Depository
Books With Free
Delivery Worldwide
But The Baby
Book reviews
& recommendations
Movies, TV
& Celebrities
Fashion Brands
Warehouse Deals
A Happy Place
To Shop For Toys
Conditions of Use
Privacy Notice
Interest-Based Ads
© 2008-2016, Amazon.com, Inc. or its affiliates


text:
The Important News:
Life isn't complete without some Star Wars news, so we heard Rian Johnson is taking on Episodes VIII and IX, which sorta made up for the bad news about Harrison Ford's broken leg.
Nor is it complete without Justice League news, and on that front was the announcement that Jason Momoa has been cast as Aquaman. Oh, and here's your first look at that, sorta. Plus a guide to everything you need to know about the underwater hero. As for other DC Comics characters, we could get another solo Batman movie in 2019.
Need help sorting out when Steven Spielberg's pile of planned movies will arrive? Release dates have been set for at least two of them. More release date excItement came with Paramount's 2016 slate, including Beverly Hills Cop 4 and G.I. Joe 3.
There's talk again of another solo Hulk movie. We know there's a Dr. Strange movie coming, and rumors are circulating about its star. But the best in superhero movie news is the dramatic Lifetime movie about Saved by the Bell.
We can't wait for the Outer Limits movie now that it's in the hands of the Sinister team. Another horror film to look forward to is the video game adaptation Dead Rising.
In sad news of the week, Matthew McConaughey might not be in Magic Mike XXL.
The Geek Stuff and Videos:
Trailers: Dolphin Tale 2, An Honest Liar, Guardians of the Galaxy, The Expendables 3, Let's Be Cops, The Knick, Video Games: The Movie, Ninjago, Dawn of the Planet of the Apes, The Judge, The Wedding Ringer, The Bronx Bull.
The first character posters for the next Hunger Games movie have arrived.
Here's a must-watch short made out of extra Lego Movie footage. And another awesome short that shows what happens after an action movie is over. And another cool video that shows what it's like to ride inside an action movie vehicle, namely Optimus Prime. And finally a scary video that shows what it's like to go inside The Purge: Anarchy.
Still need help understanding Inception? Here's a video for you.
You can now watch Tim Burton's rare Hansel and Gretel movie.
Samuel L. Jackson still knows his Pulp Fiction Bible speech by heart, as you can see here.
Watch comics writer Chris Claremont talk about the James Cameron and Kathryn Bigelow X-Men movie that never was. And here's a video that explains why so many superhero movie are made today.
Horror VHS tapes are still scary, in a new kind of way. Meanwhile, here's a story of how VHS beat Betamax for the video format of choice. Apparently, Office Space was very influential in the real world.
Check out a map of all your favorite movie locations, including Hogwarts and Gotham City. And your first look at the new Terminator. And your first look at the cast of the NWA movie Straight Outta Compton.
Our Features:
This week's guides: New streaming movies and new Blu-rays and DVDs.
Here's a guide to the graphic novels that all movie fans should be reading. And a guide to the cast of Insurgent. Also, our sci-fi expert offers us a tour of upcoming movies to get excited about.
Up for discussion: What are your top three animated features? Which movie has the best end credits? What great scenes came out of bad movies? What musicals need to be made into movies?
We picked 10 other directors besides Clint Eastwood who need to make one of those potential musicals. Here's a look at what a Book of Mormon animated movie might look like.
What's the better installment of the franchise, 21 Jump Street or 22 Jump Street? Is 22 Jump Street the best comedy sequel ever?
Speaking more of which, we spoke with the directors of 22 Jump Street about those awesome end credits. We also talked to David Gordon Green about some standout scenes in Joe. And here's an interview with The Exorcist director William Friedkin.
Turns out we had the same idea as the makers of 22 Jump Street and came up with our own ideas for the next 10 sequels.
« Cannes Lions 2014: JWT gets 2 out of 3 Indian shortlists in Branded Content What Musical Needs to Be Made into a Movie? »


text:
14 rescued, 2 missing from tall ship off NC
Published: Monday, October 29, 2012 at 9:48 a.m.
Last Modified: Monday, October 29, 2012 at 9:48 a.m.
PORTSMOUTH, Va. (AP) — The Coast Guard rescued 14 members of a crew forced to abandon the tall ship HMS Bounty caught in Hurricane Sandy off the North Carolina Outer Banks and continued the search Monday for two other crew members.
Photo Galleries
Coast Guard Petty Officer 1st Class Brandyn Hill said the crew members were rescued by two Coast Guard helicopters around 6:30 a.m. Monday. The survivors were being taken to Air Station Elizabeth City on the North Carolina coast. He had no immediate word on their conditions.
The director of the HMS Bounty Organization, Tracie Simonin, said the tall ship had left Connecticut last week en route for St. Petersburg, Fla.
"They were staying in constant contact with the National Hurricane Center," she said. "They were trying to make it around the storm."
Hill said an MH60 Jayhawk helicopter from Elizabeth City, N.C., arrived at 6:30 a.m. and rescued nine crew members who had donned survival suits and boarded 25-foot life boats. They abandoned ship after the HMS Bounty began taking on water and lost propulsion in the storm. A second helicopter arrived a short time later and rescued 5 other members of the crew.
The rescue took place in winds of 40 mph and 18-foot seas about 90 miles southeast of Cape Hatteras, N.C.
The Coast Guard initially received a call from the owner of the 180-foot, three mast ship late Sunday evening, saying she had lost communication with the vessel's crew. The Coast Guard in Portsmouth, Va., later received a signal from the emergency position indicating radio beacon of the Bounty, confirming the position.
Coast Guard Vice Adm. Robert Parker, Operational Commander for the Atlantic Area, told ABC's "Good Morning America" that at the time of the distress call the ship was taking on two feet of water an hour.
He said the crew abandoned ship into canopied, rubber life rafts with about 10 feet of water on board.
The HMS Bounty Organization website said the ship was built for the 1962 film "Mutiny on the Bounty," which starred Marlin Brando. The ship was also used in the film "Pirates of the Caribbean: Dead Man's Chest."
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
A slang term for the Australian $10 note due to it's blue/green colour.
Anyone got change for a budgie?
автор: SimultaneousK 19 января 2015
A pinching of the cheeks towards the mouth to, in a non-aggressive, comical fashion, which usually results in laughter from surrounding persons.
A generic overweight boy gave that small, generic kenyan boy a budgie. People laughed.
автор: BZ2010 4 ноября 2009
An absolute idiot, that doesn't know a good thing when he has it. Is really mean to his friends. Spends WAY too much time on his hair in the morning. Never stops playing with his.....p....hone, usually in maths.
Girl 1: have you seen that guy Budgie?
Girl 2: Yea, he looks like he stuck his finger in a powerpoint.
Girl 2: Yea, he looks like he stuck his finger in a powerpoint.
автор: VonRizzle 19 июля 2012
When a woman wears a bra thats too small her boobs will overflow the top of the bra. This boob overflow is know as a "budgie".
Carol: I hate this new bra it's too small and pinches me.
Lisa: Girl, suck it up, it gives you mad budgies.
Lisa: Girl, suck it up, it gives you mad budgies.
автор: BraveLuxan 21 сентября 2013
Originally the abaregenie for good to eat, misconception of explaining this turned it into a slang word for good food.
Oh my god flaming hot monster munch are budgie bruv
That risotto is budgie
That risotto is budgie
автор: Rubme Nice 23 октября 2010
Slang for person using a pseudonym or false identity. (Western U.S.)
"Don't ask that dude his name or where he's from. Just call him Budgie"
автор: citizenkhan 3 августа 2013
Polite word used to replace the 'C Word' where not appropriate eg; on a chat-forum such as Saintsforever where young, innocent eyes could be reading.
That blokes a total budgie if you ask me. Stop treating me like a budgie you budgie.
автор: Mik 17 февраля 2005


text:
Rice Stuffed Lamb Shanks
|Lamb shanks
|2 1⁄2 Pound (4 Short Cuts)
|Olive oil
|1 Tablespoon
|Boiling water
|3 Cup (48 tbs)
|Lemon slices
|Whole cloves
|1 Teaspoon
|1⁄4 Teaspoon
|Uncooked rice
|1 Cup (16 tbs)
|Celery leaves
1) Preheat the oven to 350°F before baking.
2) Take a heavy kettle; heat olive oil and brown meat in it on all sides.
3) Pour enough boiling water to cover the meat and add in lemon, cloves, salt, and pepper.
4) Simmer, covered for 1 1/2 hours and take the shanks out at the end of cooking time.
5) Allow to cool slightly and debone them.
6) From the broth, skim fat and bring to a boil.
7) Stir in rice and cook for about 20 minutes until soft, adding enough water if required.
8) Drain off the broth from the rice saving 1 cup for later use.
9) Add few chopped celery leaves to rice and mix well.
10) Season the rice mixture with salt and pepper and stuff boned shanks with this.
11) Take a shallow baking dish; put the stuffed shanks in it and pour in the reserved broth.
12) Bake for 15 minutes in the preheated moderate oven.
13) Serve hot.
Recipe Summary
Rate It
Nutrition Rank
Nutrition Facts
Serving size
Calories 779 Calories from Fat 379
% Daily Value*
Total Fat 42 g64.7%
Saturated Fat 17 g84.9%
Trans Fat 0 g
Cholesterol 189.9 mg63.3%
Sodium 696.7 mg29%
Total Carbohydrates 40 g13.2%
Dietary Fiber 1.9 g7.8%
Sugars 0.7 g
Protein 57 g114.5%
Vitamin A 3.6% Vitamin C 6.8%
Calcium 6.8% Iron 33.6%
*Based on a 2000 Calorie diet


text:
|Home | About | Journals | Submit | Contact Us | Français
The molecular nature of the structure responsible for proton sensitivity in KcsA has been identified as a charge cluster that surrounds the inner helical bundle gate. Here, we show that this proton sensor can be modified to engineer a constitutively open form of KcsA, amenable to functional, spectroscopic and structural analyses. By combining charge neutralizations for all acidic and basic residues in the cluster at positions 25, 117–122 and 124 (but not E118), a mutant KcsA is generated that displays constitutively open-channel activity up to pH 9. The structure of this mutant revealed that full opening appears to be inhibited by lattice forces since the activation gate seems to be only on the early stages of opening.
Most Potassium channels switch from a non-conductive to a conductive conformation by structural rearrangements in two regions of the permeation path, the inner helical bundle, located at the intracellular end of the channel [1–8] and the selectivity filter, towards the extracellular face of the channel [9–17]. In potassium channels, the inner helical bundle moves during activation/deactivation gating, initiating stimulus-dependent ion conduction [3,4,6–8,18–21].
Activation gating requires an energy transduction step where a specialized region of the channel converts specific types of physical stimuli (i.e. voltage, ligand binding, force, etc.) into protein motion. This is the case, for example, of the voltage sensing domain in voltage dependent channels [22,23] or the ligand binding domain in cys-loop receptors [24,25]. The nature of this transduction step in the prokaryotic K+ channel KcsA has recently been elucidated. A cluster of charged residues located at the intracellular end of TM1 and TM2 was identified as the proton sensor [26,27]. This charge cluster exerts attractive/repulsive forces that stabilize the inner bundle helices in its closed or open conformations in a proton-dependent way.
Here, we have pursued strategies to engineer a constitutively open channel by modifying the electrostatic balance within the pH sensor charge cluster. The basic approach relies on combining mutants, both in TM1 and TM2 segments, to bias the closed-open equilibrium towards the open conformation. We show that a charge-less KcsA mutant background with the additional mutations H25Q and the presence of E118 as a charged group have an additive effect when combined on the same open reading frame, generating channels that appear to be constitutively open at neutral pH. This also suggest that the interaction between these two charges is only partial.
Wild-type and the H25Q/E118+ mutant were expressed and purified as described previously [28], with some modifications. Briefly, fresh competent XL10 cells were transformed with WT KcsA-pQE32. Solubilization was carried out with 10 mM DDM in PBS with 1mM PMSF, at pH 7.5, for 1 hour at RT. spun down at 100,000 g for 1 hour and purified with Co2+ resin. The channel was eluted with 50 mM Tris and 150mM KCl containing 5mM DM.
Complementation growth assays were performed as described [26] by transforming LB2003 cells with a plasmid containing the test construct. Cell growth was evaluated in liquid or solid define media with 1 mM KCl and supplemented with 0.5 mM IPTG. Macroscopic 86Rb+ uptake experiments follow our described protocols for KcsA [29] using 10 mM citrate-phosphate buffer and a Dowex 50-X8 column to remove extra-vesicular 86Rb+. Liposome patch clamp experiments follow the protocols laid out in [14], with the channels reconstituted into asolectin vesicles at a 1:10,000 protein to lipid ratio (mass:mass).
Standard X-band CW EPR spectra were obtained from spin labeled and reconstituted channels as previously decribed [4] using a Bruker ELEXYS spectrometer equipped with a super High-Q resonator at 2 mW incident power, 100 kHz modulation frequency and 1 G modulation amplitude.
Electrostatic potential grid maps were calculated using the linearized Poisson Boltzmann equation by the Adaptive Poisson-Boltzmann Solver (APBS) plug-in [30] within VMD [31], as described in detail in [26] these calculations assume bulk pKa values for the ionizable side chains. Electrostatic potential maps were displayed using Pymol (http://pymol.sourceforge.net).
KcsA open mutant was expressed and purified to homogeneity. Protein stability was assessed by SDS protein-gels, western blot and gel filtration. The KcsA open mutant was crystallized in the presence of antibody Fab fragment by sitting drop method as described previously [32]. Cubic shaped crystal of KcsA-Fab complex appeared after a week in a sitting drop with the following composition 20–25 % PEG400 (v/v), 50 mM magnesium acetate, 50 mM sodium acetate (pH 5.4–5.6) at 20 °C. Crystals diffracted to Bragg spacing of 2.5 Å. Data was collected on beamline 22ID (SER-CAT) at the Advanced Photon Source and processed with HKL2000 [33]. Since the expected structure is in the open state, we used only Fab fragment and extracellular part of WT KcsA (PDB 1K4C) without the selectivity filter as search model for solving the structure by molecular replacement. In the first cycle of refinement using CNS [34]electron density corresponding to the intracellular part showed up, which is filled up with the transmembrane helices by manual rebuilding using O[35]. Multiple cycles of manual rebuilding and refinement was carried out till the complete model is built into the electron density and the Rfactors are lowered. Data collection and refinement statistics are given in Table 1.
All of the available experimental data [26,27,36] points to the fundamental role played by the cluster of charged residues surrounding the inner bundle gate in determining KcsA proton-dependent activation gating. Based on this, and the evidence supporting to the role of electrostatic repulsion as the basis for gate opening in KcsA [26], we reasoned that the best strategy to engineer a constitutively open channel was to modify the electrostatic balance of the charge cluster to bias the closed-open equilibrium towards the open conformation. Initially, we focused on a charge-less construct where all members of the cluster in the pH sensor have been mutated to Glutamines (Fig 1A).
The presence of a glutamic acid at position 118 in a charge-less background (mutant E118+) promotes a sharp right-shift in the pH-dependence of the activation curve[26]. Another potential candidate for charge engineering is E118 putative electrostatic partner, residue H25 (Fig 1B). When neutralized by substitution to glutamine, H25Q also induces a large shift in the pH dependence of activation, leading to an increased level of channel activity at neutral pH (by 86Rb+ flux assays)[26]. If the H25-E118 interaction is exclusive (i.e. forming an ion pair), the double mutant H25Q/E118+ should not have an additive effect when combined on the same open reading frame. Alternatively, a through-space Coulombic interaction would maximize inter-helix repulsion and stabilize the inner bundle gate in it open conformation at neutral pH. This is shown qualitatively by solving the Poisson-Boltzmann equation [30] using the H25Q/E118+ mutant and calculating the electrostatic surface potential at the KcsA inner helical bundle. Figure 1C shows slices through the calculated isopotential contours at ± 1kT/e (~25 mV) in 150 mM KCl pH 7, for a truncated form (without C-terminal or N-terminal helices) of wt-KcsA (Fig. 1C, top) and the H25Q/E118+ mutant (Fig. 1C, bottom), as a projected through the core of the inner gate/pH sensor (inset). wt-KcsA is characterized by alternating positive and negative fields which, we have proposed, stabilize the inner helical bundle in its closed conformation [26]. In contrast, the mutant H25Q/E118+ is characterized by an excess negative potential field generated by the sole negative charge at E118. This would result in constitutively open channel.
The properties of this open KcsA mutant (H25Q-E118+) were evaluated by four independent approaches. When used to transform the strain LB 2003 strain, which is incapable of growing in low potassium media without an active K+-selective transporter [37], H25Q-E118+ channels were able to strongly complement LB 2003 growth in both liquid culture (Figure 2A) or agar plates (not shown), compared with wt-KcsA or the positive substitution H25R. Also, reconstituted H25Q-E118+ channels showed a large shift in the apparent pKa of activation (pKa=7.9 ± 0.1) to more basic pH as judged from 86Rb+ uptake experiments, so that a large fraction of the total 86Rb+ influx is already evident at neutral pH (Figure 2B).
These macroscopic estimations of channel activity suggested that the H25Q-E118+ mutant show a higher level of activity under conditions where wild-type KcsA is functionally silent. To investigate the precise functional correlate of this constitutively open gate channel we carried out stationary liposome patch clam measurements. In sharp contrast with WT-KcsA, electrophysiological recordings of H25Q-E118+ at basic pH (8.0) show robust, single channel activity, which persists at steady state (Fig. 3). Under these conditions the single channel activity of H25Q-E118+ gradually decreases with time, as C-type inactivation sets in (not shown). Change to an intracellular acidic pH has only subtle effect, as steady state NPo decrease about 20 % (Fig 3B-C). This apparent reduction in open probability could be explained by titration of the remaining charge (E118), thus reducing the electrostatic repulsion among TM2 helices.
Finally, we evaluated the extent of gate opening in H25Q-E118+ channels by EPR spectroscopy, monitoring the extent of spin-spin dipolar coupling with a spin label at position G116. Fig. 3 shows that in WT-KcsA spectral broadening is gradually reduced in a pH-dependent way, since lowering pH promotes gate opening, increasing the inter-spin distance and reducing the degree of dipolar coupling [4]. In contrast, the constitutively open channel shows no significant pH-dependent conformational changes in a wide pH range and the extent of the dipolar broadening is compatible with a fully open inner bundle gate. These results clearly establish that the inner bundle gate in the H25Q-E118+ mutant is permanently open at neutral pH and that this opening is at least equivalent to that of WT-KcsA at low pH.
The constitutively open H25Q/E118+ represents an excellent target to further understand the structural basis of activation gating in KcsA. This construct was crystallized using a similar approach as that used to obtain the high resolution structure of closed KcsA [32]. To this end, a Fab antibody (generously provided by R. MacKinnon) was used to make a channel-Fab complex, which crystallized in the I4 space group [32]. The structure of H25Q/E118+ was solved to 2.5 Å resolution using molecular replacement methods. Unexpectedly, under present conditions the structure of H25Q/E118+ represents a conformation of KcsA unexpectedly similar to its closed structure (1K4C), although it revealed a slight opening at the bundle crossing (Figure 4). We found that the distance difference between Cα of the closed and the partial open state at residue T111 is 3 Å within the subunit and the extent of opening is ~ 4 Å at the Cα level.
Even though the present structure of H25Q/E118+ is fairly similar in conformation to the closed state, the small structural changes observed throughout TM1 and TM2 can be used to address basic questions regarding the opening mechanism in KcsA. The Cα-Cα RMSD between the closed structure (1K4C) and H25Q/E118+, illustrates that the core of the channel remains essentially unchanged, but their differences increase sharply beyond two apparent hinge points, G30 in TM1 and G104 in TM2 (Fig. 5B). This is in contrast to the expected hinge point at G99, based on the structure of fully open MthK [19]. When the relative variation of the B-factors around the local mean for specific regions of the protein are mapped onto the H25Q/E118+ structure (Fig. 5C), it is clear that the local disorder also increases sharply beyond the two hinge points described above. Although comparing absolute B-factors for structures of different resolutions is not straightforward, contrasting B-factor deviations (variance) [14] allows for a more meaningful comparison of local (versus lattice) disorder. High B-factor variance at the intracellular end of TM1 and TM2 suggests that unbalancing of the charge cluster by means of the H25Q/E118+ mutant, makes the helix bundle highly unstable resulting in channel opening, but that local disorder is enhanced by contrary lattice forces, which ultimately prevent the gate from fully opening.
Development of a constitutively open KcsA provides a unique opportunity to advance the study of the molecular basis of gating in a system amenable to a wide variety of functional, spectroscopic and structural approaches. Indeed, Thompsom et al [27] have identified a set of mutations that render KcsA constitutively open at neutral pH, but in contrast to our open KcsA mutant (H25Q/E118+), their strategy was focused on developing a residual positive electrostatic field, based on the triple mutant H25R/E118A/E120A. Thus, whether there is a local positive or negative field at the end of the inner bundle gate, helix-helix electrostatic repulsion seems to be the driving force for activation gating in KcsA.
A mutant trapped in the open conformation at neutral pH will finally allow cysteine reactivity experiments like the substituted-cysteine accessibility method (SCAM) [38] to be performed in KcsA. Further, such a mutant will be essential to tease out detailed interactions between the activation and inactivation gates, from a functional and structural dynamics perspective. But more importantly, the present mutant construct will serve as a key target to attempt direct structural studies of the open conformation of this channel. This we have vigorously pursued using an Fab-channel complex as previously shown for the closed channel [32]. Unexpectedly, the channel was only partially open and the overall structure was nearer the closed state than the expected open state (Figure 4). However, a more careful analysis of this structure revealed that the diagonally-related subunit Cα distance difference at residue 111 between the closed and the partial open state is 3 Å. Structural comparison of the two conformations point that at least at this degree of opening, the gating hinge in KcsA is located not at G99, as is typically expected from comparisons with open MthK [19], but it shifts almost two turns of a helix at residue G104. This finding, if confirmed at larger degrees of opening, suggest a wider range of hinge locations than previously thought. The large B-factors observed at the intracellular side of KcsA TM1 and TM2 are clear indicators of local disorder, suggesting that by disrupting the channel electrostatic gate (the gatekeeper), the inner helical bundle becomes unstable. At the same time, it is likely that the present set of crystal contacts inhibits the more complete gate opening suggested by our functional measurements. Close inspection of the protein-Fab crystal lattice reveals that the crystal packing is likely opposing the expanding lateral forces exerted by electrostatic repulsion in our KcsA-open mutant and thus, the present construct is not conducive to the determination of the structure of full open KcsA. An ongoing effort, based on lattice engineering, has allowed for the determination of KcsA in its fully open and a host of partially open conformations.
We thank Drs. B. Roux H Mchaourab and R. Nakamoto for helpful discussions and comments on the manuscript. S. Chakrapani, J. Cordero-Morales, O. Dalmas, J Santos and the members of the Perozo lab for experimental advice and comments on the manuscript. Assistance and support by Jim Fait and the staff at SER-CAT, at the Advanced Photon Source, is greatly appreciated. This work was supported in part by NIH grant R01-GM57846 and by a gift from the Palmer family.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
I've been playing today with a lot of progress bar types and I deviated from the project (a bit!) and ended up with this little toxic progress bar.
PS: Trust me, you don't want a taste of this. Looks yummy, but tastes awful!
keyboard shortcuts:
L or F like
post comment
Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
Copyright © 2009–2016 Dribbble LLC. All screenshots © their respective owners. Shipped from Salem, Mass. USA.


text:
I got a monitor with DVI-D and DisplayPort, and I have a a notebook and a graphics card I want to connect to it. The graphics card has DVI-D output, so that's the simple part. But the notebook has HDMI only. How do you connect HDMI to DisplayPort? I only found adapters for the other way round, which are also fairly expensive (i.e. DP->HDMI.) Or should I get a HDMI to DVI and then a DVI-Y-cable to connect everything via DVI?
An HDMI to DVI adapter would be more natural as the two connections carry the same video signals. Don't try to save $2 and get the wrong one. The one I linked to will work for all current HDMI to DVI connections.
DVI and HDMI carry the same signal, DisplayPort and HDMI do not. Every DVI connection can be passively converted (i.e. using an adapter, not a converter) to HDMI. DisplayPort can only be passively converted (i.e. using an adapter) to HDMI if the DisplayPort in question is designed for "dual mode", otherwise an active converter box will be needed.


text:
Café Direct Fair Trade rich roast coffee
£3.50 (£1.55 per 100g)
Product Summary
Our Richest Blend. Deliciously dark, intense and bold. Rich Roast is freshly ground from the finest Latin American & African beans, nurtured and roasted to perfection. Giving you a deliciously smooth, intense, and full bodied coffee.
|Mixed Material
Please note that whilst we take every care to ensure the product information displayed on our website is correct, product recipes are regularly changed and this may affect nutrition and allergen information therefore you should always check product labels and not rely solely on the information presented here.If you require specific advice on any Waitrose branded product, please contact Customer Support on 0800 188884 or email email@example.com. For all other products, please contact the manufacturer.This information is supplied for personal use only. It may not be reproduced in any way whatsoever without the prior consent of Waitrose Limited nor without due acknowledgement.


text:
Originally Posted by .WestCoastHucker.
there many of threads about this subject in the DJ forum. about once a month a more than informative thread generates...
I just found the dirt jump forum last night
I think I created that a couple years back.
Originally Posted by Dion
Froride1 and I had a talk about this yesterday, and my theory is that many MTB'ers are looking at the climbing/fitness/endurance aspect of the sport - sticking to fireroads and killing KOM's and such. Not that there's anything wrong with that, but you lose sight of a very important aspect of riding.
I have a lot of work to do on my climbing speed (at least I'm not dead last like before), but I really enjoy having the bike handling skills - makes up for what I'm not so good at.
There is a lot of truth to this.
Most people are not racing, but focus on the "racing" part of their riding.
As Dion said, there is nothing wrong with that, but it sure presents a limitation on the variety of the sport.
I got myself a trial bike today, just for the kicks. Somehow I am quite sure that's gonna be a lot of fun. It has no purpose, I am never going to compete, and most likely never going to hit world class skills either.....but the fun that will bring, ooh yes!
Had he been my son, I would have gone with whatever he thought was fun, and let him evolve over the years.
After all, it's a lot nicer that he finds bikes interesting, no matter what type, than that he ends up being bored with it.
you guys are so wise.
and thanks for the mention about the DJ forum. I gots some reading to do.
if you don't find the info you are looking for, just like any other forum, just ask with a legitimate question and you will get responses. we have quite the knowledgeable bunch there. some kooks too, but they're everywhere...
One thing that's popular is the Wed. night rides at Stanford (???). I had a trials bike, but realized, I can ride trials on my BMX bike (front + back brake, gyro and 4 pegs), which I rode trials on BITD. We rode trials and didn't even realize we were riding trials - we were just "freestyling".
I have changed my attitude about riding a lot in the last few months, really relating it to the passion I had for BMX when I was younger. We just rode, no rhyme, no reason... just point your bike out the front door and start pedaling. I'm less about doing hill intervals and more about riding to ride, and not riding because I'm going to be pro.
I will never be pro. I will never podium races, nor will I ever be the fastest climber nor downhiller - but I will always have fun.
On Saturday, a bunch of my friends from Hayward did a 40 mile ride on their BMX bikes - 40 friggin' miles. They stopped and sessioned embankments, parking lots and planter boxes. They jumped curbs and bunnyhopped stuff. These guys are my age, and it took like 12 hours.
Puts things in perspective for me.
Newton - stop over-thinking it. You're putting too much mathematics into the equation - just ride. Less reading - more riding. I can teach you some basic bike handling stuff like rock-walks, pedal-offs and such. They're easy to do.
If you get a dirt jump or BMX, we'll go session - I have a group of BMX buddies in our age group that are cool and have some cool spots to session. Nobody judges and everybody has fun - I'll take you to my old street session spots in Santa Cruz. If all you want to do is learn how to ride off planter boxes, do it. Next time we go to Demo, 2' - 3' drops will be nothing.
Originally Posted by IAmHolland
you guys are so wise.
and thanks for the mention about the DJ forum. I gots some reading to do.
Known bike lessons are:
Bikeskills Bay Area Mountain Bike Skills Instruction
Mountain Bike School, Mountain Bike Camps, coaching by Betterride
Lee Likes Bikes
Trek Dirt Series: Mountain Bike Camps, Clinics & Instruction. Women's Only and Co-ed, based in Whistler, BC - mostly women only
I have no experience with any of them except Dirt Series, which is mostly women only.
Originally Posted by francois
Known bike lessons are:
Bikeskills Bay Area Mountain Bike Skills Instruction
Mountain Bike School, Mountain Bike Camps, coaching by Betterride
Lee Likes Bikes
Trek Dirt Series: Mountain Bike Camps, Clinics & Instruction. Women's Only and Co-ed, based in Whistler, BC - mostly women only
I have no experience with any of them except Dirt Series, which is mostly women only.
Thanks. I've seen the Dirt Series, and get jealous.
I've taken a Betterride 3-day basic course. Very informative, but nothing about pump and jump. Maybe the DH series? It's probably too advanced for me.
I'll check out the others.
Originally Posted by Dion
Newton - stop over-thinking it. You're putting too much mathematics into the equation - just ride. Less reading - more riding. I can teach you some basic bike handling stuff like rock-walks, pedal-offs and such. They're easy to do.
Kinda hard for me. I'm an engineer. Everything I do runs through a thousand calculations in my mind, I mean *everything*. Sometimes the thoughts don't happen fast enough when I'm riding and I mess up. When I go along a trail, I see trail length, endurance capacity, angles off every object, speed, thrust, momentum, plotting out a trajectory. It's OCD. I have a hard time just "flowing" unless I've ridden there a dozen times.
Sure, I'll go for lessons by Dion. I just don't session stuff. I'll buy a proper BMX bike first. 20" wheels.
Originally Posted by IAmHolland
Sure, I'll go for lessons by Dion. I just don't session stuff. I'll buy a proper BMX bike first. 20" wheels.
When I was a kid, the Rite of Passage was being able to bunnyhop up the quad stage at Santa Cruz High. Back in those days, it was much taller, about the height of a top tube of a BMX bike standing up. Once you could make it up that, you were "a man".
I wanted to work myself up to it, so, like any kid I learned how to bunnyhop up a curb. After that, we stack skateboards and bunnyhopped those... but then I got this idea of building a "bunnyhop measuring thing" and we made saw horse type stands that had a piece of PVC pipe that would fall off if we didn't clear it.
Once I got to the SCHS quad stage, it was a piece of cake. Then, I realized that picnic tables were only 6" higher than the stage, so I started bunnyhopping that. Harbor Highschool had a crazy high stage (the height of my grips on my BMX bike standing up), and we were able to bunnyhop up that, soon after. But it all started with a curb.
Same thing with 360º's. Once I learned them off curbs, I started doing them off 2' high planter boxes, then the SCHS stage, then picnic tables. Then we started clearing stairs. First two stairs, then 3, then 4... and on.
You kinda have to work incrementally. Start with curbs and work your way up. It's all about feeling, so you're gonna have to let your OCD go, man. Bruce Lee understands BMX for old dudes.
wide bars, thin pedals. definitely a front brake for a beginner. I run gears because I want to be able to do light trail riding and choose the perfect gear at the park but it does add significant weight to the back of a bike that is made specifically to be in the air.
for dirt tires the sb8 is good and intense micro knobbies are popular too. on more mixed terrain theres the maxxis holy roller which I didn't like much in the dirt, the kenda k-rad, and schwalbe table top if you like spending a lot
What is this DJ forum heresy you all speak of?
After reading the animated responses and heartfelt information....I may have to check it out. Maybe learn something for once !
Poaching Demo...that's why we can't have nice things...
Originally Posted by francois
Yup, I have learned more about bike handling in the last 6 months compared to my last 12 years of riding. Most mountain bikers like me have never had a bike handling lesson. Most never get advice, seek advice on how to corner or do a drop.
It's true. After a few hours and some fresh hops in the FC man cave I came away with advice that made me faster on my next ride. (descending that is)
Brother Seamus?
Like an Irish monk?
Comic relief in a discussion does no harm..
CS Lewis
I need to log some on a pump track. I figure pump track stuff and some general playing on some urban stuff can't do anything but help with skills... One of the days i'll make it back to Calabazas park. Spend an afternoon fooling around on the Chameleon... hopefully not breaking my self.
To those of you looking for jumping instruction and just overall DH handling skills instruction (cornering, drops, braking), I'd highly recommend this video. Fluidride » Fluidride: Like a Pro – DVD
I'm sure taking a course could be helpful as well, but much more expensive and there's only so much they can show you. I took one skills instruction session a few years back (not jumping) and found it a bit nerve wracking. You watch the guy do it the right way and then everybody gets to watch you demonstrate your lacking skills. Too much pressure.
I think the video route is perfect because you can watch it repeatedly in between practice sessions. They really break down all the movements and use alot of slowmo to help visualize what's happening. And the intro trail riding segment is really cool. It always got me pumped to improve my skills so that hopefully I could ride like that someday. I made alot of progress, but I'll never be Lars .
Ze frame is here as I got a sweet deal and I have most of the parts.
I don't think my kid likes the idea of the 26er. It turns out Bob Burnquist coached him on a bmx bike at the Dew tour.
We'll build this up and pick up a bmx. We'll see how it turns out as we ride together anyway.
I have a 2010 We The People Zodiak (grey/blue) that your son might love. It has barely been used. I'll sell it to you/him cheap or trade for MTB gear :-) PM me if you're interested.
We The People Zodiac 2010 - YouTube
Full 4130 CroMo 20.8" top tube
Full 4130 CroMo
Salt Expert
Salt CNC 6061 T6 Alloy 25 tooth
Bottom Bracket:
Sealed mid
1 piece sealed 9 tooth driver
Salt pro
Eclat Surge PC
Front Brake:
Rear Brake:
Salt Moto ubrake
Brake Levers:
Salt Moto alloy
Full 4130 CroMo
Salt Pro full CNC'd
Salt Internal sealed
WeThePeople OD grips
Salt double wall 36 hole
Front Hub:
Salt pro bolt, female axle
Rear Hub:
Salt sealed cassette
Front Tyre:
WTP Feelin 2.25
Rear Tyre:
WTP Feelin 2.1
Eclat Gonzo Pivotal
integrated into frame, but possible to cut off and run normal seatpost
We slapped it together tonight. He loves it. It's definitely work in progress but we're pretty excited now.
Nice!! He is stoked. Life is good.
Last edited by One_Speed; 11-08-2012 at 11:09 AM.
Reason: already getting bmx!
awesome!! Lucky kid for sure...
The jumps and pump track in Elk Grove are fun, I bring my full suspension out to practice every now and again.............and, my daughter likes to stand at the top and watch!
Master of Nothing, but dammit if I don't try..............
Child down.
Ok, major setback. We snuck in a session at the park yesterday to get a feel for the bike. It's really light and fast. Moments after I took this video
Miguel with new Spank bike at Calabazas - YouTube
he dropped in to the big side without brake checking. On the first jump, he endoed and crashed into the next jump. He was crumpled into the ground and was dazed. Nothing can really prepare a dad for that scene and I'm still having a hard time with it.
I thought he shattered his clavicle as we took him to the ER. Verdict is the outer tip of the clavicle is broken and the clavicle is stretched up a bit. No surgery for now as we'll let it heal on its own and do physical therapy.
He is now at home recovering with meds. Family is by his side and friends are coming over. Thank you for all the kind words in Facebook.
This is a setback for sure. Hope he comes out of it ok.
Ah, major bummer, but a natural progression for a mountain biker. I'm sure he'll be itching to ride again before the doc even clears him. I know a few people who've even had casts formed around their handlebar...it's a mountain biker thing I guess.
Oh no! Poor Miguel - I ate it the exact same way on those same little jumps and was pulling gravel out of my elbows for months.
The worst head injury I ever had was at Cali many years ago, when I wasn't much older than Miguel. Heal up, kid! We spilled the same blood in the same mud
Sorry to hear man. A similar thing happened to me a few months back at Z's, and I thought I broke some ribs or the sternum and my jaw. I did not get any confidence for descending, for a long time. I'm just finally getting my confidence back. Though, I won't take a jump now until I get the basics down.
I hope he gets better.
So, truth time....did the mrs. really lay into you? Just curious, I wouldn't hear the end of it, if it was my son, or worse my daughter. Fortunately, for me, it was just me and the mrs. didn't care that much, just another one of my billion crashes.
I took a glamour shot of my bike:
Sorry to hear about your son. I think that's every parents fear to see their child hurt. Healing vibes and wishing him a speedy recovery.
Forum Rules


text:
Men's basketball player Steve Jackson and women's soccer player Katie Henley were named Presidents Award winners Friday at the annual West Texas A&M Athletic Banquet.
Henley was also named the women's most valuable player in her sport, making her the only athlete honored with two awards.
The following athletes were recognized:
CROSS COUNTRY: Most Valuable Female Runner: Stephanie Williams. Most Valuable Male Runner: Jose Velasquez.
FOOTBALL: Chaun Thompson Award: Darrell Lewis. Buck Garrett Team MVP: Dalton Bell. John Ayers Academic Award: Keith Null. Offensive MVP: Tonae Martin. Defensive MVP: Max Steward. Special Teams MVP: Jacob Felton. Fighting Buffalo Junk Yard Dog Award: Pat Schwenke.
BASEBALL: Outstanding Player: The 2006 LSC Tournament team.
GOLF: Women's Low Average: Rachel Clark. Outstanding Lady Buff: Beth Ann Nussbaum. Men's Low Average: Paul Slaughter. Outstanding Buff: Jon Musser.
BASKETBALL: Women's MVP: Keisha Monroe. Tough D Award: Emily Brister and Kara Pridey. Award of Excellence: Jennifer Brock.
SOCCER: Women's Offensive MVP: Katie Henley. Women's Defensive MVP: Jessica Hartley. Women's Newcomer of the Year: Elizabeth Markussen. Women's Golden Buffalo Award: Roxy Sibes. Men's Offensive MVP: Josh Fender. Men's Defensive MVP: Kenneth Christensen. Men's Newcomer of the Year: Tom Nutter. Men's Golden Buffalo Award: Kenneth Christense.
SOFTBALL: Most Valuable Player: Brooke Guidry.
PRESIDENTS AWARD: Male: Steve Jackson, basketball. Female: Katie Henley, soccer.
Amarillo Globe-News © 2016. All Rights Reserved. Terms of Service | Privacy Policy / About Our Ads