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|Prev Close
|Day Low/High
|12.88 / 13.50
|52 Wk Low/High
|6.00 / 19.76
|Avg Volume
|Prev Close
|Day Low/High
|12.88 / 13.50
|52 Wk Low/High
|6.00 / 19.76
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|P/E Ratio
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Trade-Ideas LLC identified 3D Systems (DDD) as a weak on high relative volume candidate
- Custom orthotic boot created using 3D scan-to-print workflow improves mobility of endangered African penguin
3-D Systems, Stratasys look ready to make at least a short-term move higher.
Over 250 new features and enhancements deliver improved productivity and intuitive user experience
Here's a look at how to trade five stocks that are poised to break out and trade higher from current levels.
Trade-Ideas LLC identified 3D Systems (DDD) as a "perilous reversal" (up big yesterday but down big today) candidate
Top aerospace and defense companies share best practices for leveraging metal additive manufacturing in end-use part production
McMullen served as CFO at Kodak as well as SVP of Finance and Corporate Treasurer at HP
First and only available TAPP procedural training module now offered on 3D Systems' LAP Mentor™ and the RobotiX Mentor™ simulators
These unknown innovation growth names all have very solid underlying growth fundamentals.
HP Inc. is scheduled to report results of its second fiscal quarter after the market close on Wednesday, May 25, with a conference call scheduled for 5:00 pm ET.
It's not an easy call when coming out of a choppy market
3-D printing just got a big dose of competition from HP. Why are you still holding 3D Systems stock?
Complete ecosystem of printers, materials, software, services, and partner network unlocks full potential of 3D printing
3D Systems stock is poised to regain a key technical level on any bit of good news.
TheStreet highlights 3 stocks pushing the computer hardware industry lower today.
3D Systems (DDD) stock is falling after the company reported a $17 million loss for the 2016 first quarter.
Shareholders appear reluctant to get back on board with the struggling manufacturer, despite its new CEO's sunny outlook.
Trade-Ideas LLC identified 3D Systems (DDD) as a weak on high relative volume candidate
Cramer is avoiding Ambarella but likes Discover Financial Services.
Cramer compares Buffett's long timeframe to Icahn's quarterly shifting, and sits down for a rare interview with Tim Cook, Apple's CEO.
The most recent short interest data has been released for the 04/15/2016 settlement date, which shows a 2,819,578 share decrease in total short interest for 3D Systems Corp. , to 25,028,838, a decrease of 10.12% since 03/31/2016.


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Loss of Lives in Clinical Trials...
Researchers Now Have a Myriad of...
Keep the Opportunities, Lose the Opportunists
Capitol Hill Critics Second-Guess Agencies Using...
The NIH National Institute of Allergy and Infectious Diseases (NIAID) awarded Advanced BioScience Laboratories (ABL) a contract to provide preclinical development and cGMP manufacturing support for multiple vaccine and biologic products identified by NIAID program staff. The contract has a funding potential of up to $102 million over 10 years.
Under the contract titled, "Manufacture and Characterization Services (MCS) for Vaccines and Other Biologics for Infectious Diseases," ABL will provide services from early feasibility studies through manufacture of Phase I and II material to close development and production gaps and increase the government's response to emerging disease threats. ABL will also provide appropriate documentation and support for regulatory submissions for Phase I and II clinical testing.
"We are extremely excited at the prospect of applying novel approaches, platforms and technologies in support of NIAID's mission to develop candidates against a wide range of infectious diseases," said Thomas VanCott, Ph.D., president and CEO of ABL. "This will be a great opportunity for ABL to develop vaccines and therapies targeting some of the most challenging agents including potential bioterror threats, drug-resistant pathogens, and emerging and re-emerging infectious diseases."
ABL previously received funding from the NIH National Heart, Lung, and Blood Institute's Science Moving towards Research Translation and Therapy program in February to manufacture recombinant human lecithin-cholesterol acyltransferase for the treatment of familial LCAT deficiency.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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subset: commoncrawl


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Bollywood actor Kunal Khemu was injured when an angry mob pelted stones at the actor and the crew who were shooting for a romantic single in Lucknow. The incident took place in the wee hours of Saturday, June 11, when the unit was shooting at the historical 'Bada Imambara' in old Lucknow.
Blood Money Movie Review
Directed by Vishal Mahadkar, Blood Money deals with the diamond mafia. The film stars Kunal Khemu and Amrita Puri of Aisha fame in the lead roles.
kunal khemu
In arranged marriages, the family looks for the bride to be younger than the groom, but this is no longer the trend or norm. There are men who fall in love and marry older women and vice-versa. Bollywood actors Bipasha Basu and Karan Singh Grover fell in love on the sets of their film 'Alone'. Bi
Recently, it was reported that Bollywood couple Kunal Khemu and Soha Ali Khan are headed for a divorce. But Kunal has strongly reacted to the reports and dismissed them as rumours. The 'Bhaag Johnny' actor took to Twitter and rubbished the reports of his trouble in his marriage with Soha.
Latest Bollywood News
- TV couple Daljeet, Shaleen to file for divorce on Monday
- Sidharth takes ladylove Alia Bhatt on a late-night drive
- Arjun Bijlani gets injured while rehearsing for 'Jhalak Dikkhla Jaa 9'
- Kareena Kapoor to deliver her baby in London?
- Sanjay Dutt rings in wife Manyata's birthday in Dubai


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Marmion takes on Aurora Central Catholic Friday in Week 8 action. Follow the game here with video from High School Cube, then come back later for the replay and highlibhts.
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Whether you're traveling to Myrtle Beach on business or just need to get a little work done while you're here, you'll love our Business on the Beach Package. Your package includes:
To book online, click through to one of our properties:
Not sure which accommodation to choose? Compare here.
Catch up on reading while catching some rays at our oceanfront Myrtle Beach Resort.
This Myrtle Beach hotel package includes accommodations of your choice, breakfast for two each morning, and a Books-A-Million tote bag containing a $20 gift card to spend at Books-A-Million. You'll also receive a men's cap, women's visor, two bottles of spring water, and lip balm. All you have to do is stay in one of four properties for a minimum of two nights:
Not sure which accommodation to choose? Compare here.
Memories are made on your Myrtle Beach vacation - hold onto them with Kingston's Beach Memories Package and share them for years to come. As well as staying in our fantastic resort - with Sports & Health Club, Splash! waterpark, oceanfront dining, and more - you'll also receive the following:
To book your Beach Memories package, choose your accommodation from below:
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Enhance your romantic vacation with the Romance Package at Royale Palms Condominiums.
Enjoy a range of romantic extras, including complimentary sparkling wine or cider on arrival, breakfast for two in your luxurious room, and full use of the Sports & Health Club with pool and whirlpool. You'll never want to leave, which is why we've also included late check-out. Make the most of your vacation with a loved one and book our Romance Package today.
Whether you're planning a special occasion or simply need to unwind after a hectic workweek, make the most of your weekend and book a Bed & Breakfast package! With special rates and breakfasts for two - from healthy to decadent - our Bed & Breakfast packages are the perfect way for you to relax and recharge.
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Wake up to breakfast for four, Internet access, and late checkout when you book the Family Fun Package. Start each morning of your trip on a full stomach, and after the day's adventures are done, take advantage of your Internet access to share photos with friends at home or plan your next trip.
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Philadelphia Imposes $300 Licensing Fee on Bloggers
On the home page of the city of Philadelphia's Web site, the slogan "Life, Liberty and You" appears at the top. Immediately beneath it is a bank of links where citizens can make online payments for city fines, taxes, and fees.
The City of Brotherly Love and the cradle of U.S. independence also recently began enforcing a business privilege license on the city's bloggers. Residents operating Web sites that earn money may choose either to pay a one-time $300 fee or $50 each year. The move is being characterized as a way to generate revenues for the city's budget shortfall.
"Philly is levying a $300 license fee on bloggers?" asked Detroit News political cartoonist Henry Payne, who also blogs and edits The Michigan View Web site. "Sounds like something King George III would have levied to keep Tom Jefferson from penning the Declaration of Independence. How about a $300 license fee on being a tax-grubbing city bureaucrat? We bloggers will soon be a sub-class of scofflaws illegally blogging after midnight to the glow of our illegal incandescent light bulbs."
'Greedy Tax Collectors'
Philadelphia City Paper intern Valerie Rubinsky broke the story on August 18. Rubinsky reported municipal residents who had reported Web site income on their federal tax returns had received correspondence from the city reminding recipients they were required to apply for the license and pay city taxes on their Web income.
"Activity for profit and blogging aren't words usually used in the same sentence—or ZIP code, but the greedy tax collectors in Philadelphia City Hall have decided bloggers now qualify as for-profit businesses subject to a $300 privilege license," said Payne. "The City of Brotherly Love is going to get a lot less civil as city tax agents kick down the door of every college kid, soccer mom, and tea partier blogging in their spare time."
'Stamp Act Is Back'
A phone call to the city's Business Services office for clarification was terminated by a city employee when the purpose of the call was identified as source material for this story.
"The Stamp Act is back, with the Crown meting out its pound of flesh from citizen free speech practitioners," said Seton Motley, editor in chief of StopNetRegulation.org.
"Taxing bloggers will only do what taxing always does—drive the least among us out of the business," Motley continued. "Shutting up bloggers by shutting them down is an assault on the First Amendment. There's no cover charge to get into the Constitution. At least there shouldn't be."
Bruce Edward Walker (firstname.lastname@example.com) is managing editor of Info Tech & Telecom News.
Internet Info:
"Pay Up," Philadelphia City Paper, August 18, 2010: http://citypaper.net/articles/2010/08/19/blogging-business-privilege-tax-philadelphia
Philadelphia Privileged Business Licensing Permit application: http://business.phila.gov/Documents/Licenses/bizpriv.pdf
Articles By Bruce Edward Walker
West Virginia Education Chief Announces Common Core Repeal
School Choice Advocates Concerned New Louisiana Governor Will Roll Back Reforms
'Choosing Charters' Website Launched by Michigan Think Tank
Poll: Education a High Voter Priority Neglected by Presidential Candidates
Idaho Department of Education Requests Public Review of State's Standards


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Health & Pregnancy
Bonding With Baby Before Birth
Jeanne Berkowitz is expecting a baby in late January. In October, Jeanne and her husband went to Hawaii for a "babymoon." While there, Jeanne got a massage from a woman who works frequently with pregnant women.
"She told me that it was important to massage my belly often to introduce the baby to human touch and to the world outside the womb," Jeanne recalls, adding that she now massages the baby regularly, as does her husband. "We can often feel him respond by kicking back and changing positions."
Jeanne says she's not an expert on the benefits of prenatal massage, but reports that "it's fun for us, helps us (especially my husband) think of the baby as a real person, and I can't help but think it has to be good for the baby, too."
Jeanne might be interested to know that there is indeed science to back up her intuitive feelings. According to Carista Luminare-Rosen, PhD, author of Parenting Begins Before Conception: A Guide to Preparing Body, Mind, and Spirit for You and Your Future Child, research shows that babies in the womb have the emotional and intuitive capabilities to sense their parents' love. "Prenates can see, hear, feel, remember, taste, and think before birth," says Luminare-Rosen, founder and co-director of The Center for Creative Parenting in Marin and Sonoma counties, Calif.
Bonding (also known as attachment), says Marilee Hartling, RN, prenatal program manager at Cedars-Sinai Medical Center in Los Angeles, is how babies -- before and after birth -- learn what the world is all about. "It's also part of their personality development.
"When there's a healthy attachment between baby and parent," Hartling says, "the baby comes to believe that the world is a safe place. This is the beginning of the establishment of trust."
Some parents talk about feeling connected to their baby from the moment it's conceived, says Hartling. For others, that feeling grows as the baby develops. Fathers tend to begin bonding later than mothers, for obvious reasons, Hartling says, but they can help the process along by going to doctors' visits with the mother, looking at ultrasound pictures, and feeling the baby's kicks.
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Hi, I live in central
Hi, I live in central California, and I have a lilac tree that is over 10 years old. Every spring, it has bloomed beautifully; however, this last spring, we had some really cold winds, and neither the leaves nor the flowers opened all of the way. Since then, I have had no new foliage, and what I did have has turned brown. I do not believe that water is a problem, and when I cut off a small cutting, the wood is clearly green and still alive. I would appreciate any advice that comes my way. Thanks! Kim


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Once upon a time, a girl was on her way to Grandmaâs house when she was attacked and left for dead. Far from a fairytale, Elle has found herself out of her mind and her body, and canât figure out who her attacker was. Now, in the physical realm, that question is about to get an answer. Who is the Big Bad Wolf in Elleâs life? The answer changes everything she thought and everything the people around her imagined!
PREVIEWS: "Daredevil," "Uncanny X-Men," & More Marvel Comics On Sale August 3, 2016
Comic Books


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whatever the hell you want it to mean, as long as it has nothing to do with fizzles or the vagina for that matter
Well my fi (friend) Mike got so fi (pissed) the other fi (night) that he stripped naked and we all said "holy fi (shit)! he's got a lil fizzle!"
by gribble February 02, 2003
Trending Now
Top Definition
Another word for 'TO'
Seh mi and Gurpz Resi link up kum fi create a plan
Lizten fi da man
Lizten fi da man
by Gurpz Resi May 04, 2004
fiancé, the man who a woman is engaged to be married to
my FI has huge fingers. The jeweler measured him at a 15.5 but said to order a 16 if we wanted a thicker band. My FI is 6'4" and a big guy so it makes sense.
by musterionanonim February 21, 2013
Fuck It!!!
I was trying to do something good, but I just said F.I.
by WOrkthatclit July 19, 2009
A common abbreviation for fish
"Look in that pond, there are two fi.s (Pronounced F-I-Dots) They are orange!"
by Jenny Any Dots April 14, 2006
Factual Information.
Confirming a statement.
Confirming a statement.
Going for a dump this morning Gaffer?
by Tommytux December 15, 2006
An FI is an an abbreviation for Fucking Idiot. You see these driving on the roads every fucking day. You can also find them in the workplace, in stores, and health clubs, police departments, and yes hospitals too. Most of them are men, but some are women.
That FI cut me off!
by Non FI May 29, 2014


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Filosofie francescane – Franciscan philosophies
Doctor Virtualis 14
Call for paper
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Doctor Virtualis 14
Call for paper
Since the era of slavery and continuing through the present, Black women have articulated a vision of freedom, equality, anti-racism, and racial uplift, drawing from Scripture to sustain their work of promoting equal rights for African Americans. From the early female abolitionists such as Maria Stewart, Sojourner Truth, and Harriet Tubman, to the anti-lynching activists Ida B. Wells and Mary Talbert, to the twentieth-century civil rights activists Ella Josephine Baker and Septima Clark, and countless others, these "churchwomen" actively challenged the status quo that relegated Black women to the least empowered positions in the social order.
Please note the new deadline for proposals: October 5, 2015.
In "Refugee Memories and Asian American Critique," Viet Thanh Nguyen suggests that a category of refugee literatures outside of disciplinary borders of national literatures "allow[s] a different set of connections across time and space that point somewhere else besides assimilation into the nation and to affiliations with other people besides US citizens" (934). What connections are necessary to make, and what kinds of borders do we have to cross, in the teaching of refugee literatures? With Nguyen's words in mind, this roundtable session aims to explore our encounters with literatures of refugee experience in the classroom.
Premodern plant studies debuted at Kalamazoo in 2015 with the first "Secret Lives of Medieval Plants" panel. In this follow-up panel for the 42nd Annual Sewanee Medieval Colloquium on Medieval Natures (1-2 April 2016), we want to continue the work of pushing back against plant blindness and zoocentrism in analyses of medieval culture. Even as medieval people nominally operated within a Platonic-Aristotelian framework treating plants as "inanimate" and "non-living" (Matthew Hall's terms), they nonetheless recognized diverse forms of vegetable agency in practice.
The Michigan State University Comics Forum - http://www.comicsforum.msu.edu - is an annual event that brings together scholars, creators, and fans in order to explore and celebrate the medium of comics, graphic storytelling, and sequential art. This year's event is scheduled to take place February 26-27, 2016 at the Residential College in the Arts and Humanities in Snyder/Phillips Hall on the campus of Michigan State University.
Volume 2.2 (Summer 2016) will highlight the work of Caribbean Writers, Performance Artists, and Visual Artists working from Canada.
Critical essays on all aspects of Caribbean Writers [working from Canada] are welcomed entries.
Previously unpublished poetry and literary nonfiction from Caribbean artists [working from Canada] are welcomed entries.
Visual art images and video links to performances by Caribbean artists [working from Canada] accompanied by artistic statements also will be accepted for publication consideration.
Interviews with Caribbean Artists [working from Canada] will be considered as a special feature of Volume 2.2 (Summer 2016).
For the winter issue our theme colors are blue and white and the theme of writing is expected to go according to the color. So, the theme for submission for the next issue is "Innocence with Alienation and Chaos". This time we are happy to include two more genres – short drama and flash fiction. As our webzine is a combination of literature and art, this time we would be happy to have photo stories and art pieces as well.
"Pleasure and Suspicion"
Conference Hosted by Duke University Program in Literature and the Polygraph Editorial Collective.
Keynote addresses by Joan Copjec, Brown University & Eugenie Brinkema, MIT
February 26-27, 2016
Abstracts of 250-300 words Due by November 16, 2015 to firstname.lastname@example.com
CFP: The Literature and Films of the War in Iraq
Northeast Modern Language Association
Hartford, CT March 17-20, 2016
Contact: Zivah Perel Katz (firstname.lastname@example.com)
Chairs: Nicole Zeftel (CUNY Graduate Center) and Allison Siehnel(University at Buffalo)
Contact email: email@example.com
Submissions: online only at https://www.cfplist.com/nemla/Home/S/15802
Submission deadline extended: October 5, 2015
The CEA 2016 Call for Papers for its annual conference (March 31-April 2, 2016) invites submissions on the broad topic of creation (http://cea-web.org/) . That cfp includes a discussion of creation as an act which can "stimulate creativity or creation in others." As educators of literature or composition, what kinds of messages are we sent about incorporating "creativity" in our classrooms, and what kinds of concerns or frustrations does such championing of creativity in our pedagogy raise?
Longfellow, Writer of Books: Interpretations of the Single Volume or Collection
This panel for the NeMLA 2016 Annual Convention, to be held in Hartford, Connecticut, from March 17 to March 20, 2016, seeks papers that continue the renaissance in the study of Henry Wadsworth Longfellow (1807-1882). The submission deadline has been extended to October 5, 2015.
Submission Deadline Extended to October 5, 2015.
In "Refugee Memories and Asian American Critique," Viet Thanh Nguyen suggests that a category of refugee literatures outside of disciplinary borders of national literatures "allow[s] a different set of connections across time and space that point somewhere else besides assimilation into the nation and to affiliations with other people besides US citizens" (934). What connections are necessary to make, and what kinds of borders do we have to cross, in the teaching of refugee literatures? With Nguyen's words in mind, this roundtable session aims to explore our encounters with literatures of refugee experience in the classroom.
This panel calls for papers that stake a claim in the cultural significance of representing alcohol or alcohol consumption. How do these representations relate to alcoholism as a disease and the alcoholic as an identity category? Does the text evaluate alcohol abuse morally or politically? Do communities organized around alcohol consumption facilitate social movements based on class, race, sexuality, or gender?
The focus of this panel is the relationship between writing and religion in the period of the Enlightenment (broadly interpreted). We invite proposals for 20 minute papers on this theme in relation to texts, from the canonical to the unpublished, connected with or produced by different religious denominations and communities (Anglican, Dissenting, Catholic, Jewish, Baptist, Quaker and others).


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Let's Talk Investing
What's ahead for housing in Canada? Add to ...
The Globe and Mail
Last updated
What would slower borrowing growth mean for housing, and will houses remain affordable in most markets despite rising prices? Rob Carrick investigates
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As prices climb, 'tiny homes' pop up in Victoria
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What demographic is feeling the biggest financial strain as homeowners?
Money sense: How to make your savings last as long as you do
Why putting off tough financial choices usually make things worse
Housing affordability: Not just Toronto and Vancouver issues
Why Vancouver housing might be at the top
UK property funds take more Brexit hits
Canada's bank watchdog eyes housing market
Data show impact of foreign real estate ownership
Canada's top bank regulator vows to tighten mortgage underwriting


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GM Dealer Explains Why He Closed Shop
The Mark Buick-Pontiac-GMC dealership in Yonkers, N.Y., closed recently after 40 years in business.
"We got into a situation where the demands that were imposed upon us or the requests by the finance companies became untenable," Mark Herrmann, the former owner, says. "Unfortunately, based on economic factors of the last six or seven months ... we saw our volume fall and, obviously, our profits diminished to the point where they became losses."
He says closing the dealership was a difficult decision because of his loyal employees and customers.
Herrmann has been invited to take part in the National Automobile Dealers Association lobbying campaign in Washington next week. He says the group wants to meet with lawmakers about the government mandate for struggling U.S. automakers to shut a certain number of dealerships.
"I don't know a darn thing about running a government," he says. "I'm starting to recognize the fact that, maybe, our government doesn't know anything about running car dealerships."
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Joggers + Cops = Must-see TV.
And, totally unrelated, a recent news item about a Canadian jogger.
A tweet from the former TV host prompts many questions. Like, "Huh?"
From across the pond comes yet another peril for joggers.
The victim is reported to be OK. Which is very good news. Still...
It's only a matter of time before it happens to you. Be prepared.
Happy (belated) National Jogging Day! Be careful!
A Utah man, out for an early run, thought there was a ledge over a barrier. There wasn't.
Apparently, when you're a jogger, it can be difficult to tell. This chart will help.
We interrupt today's regularly scheduled column for some urgent, alarming news.
Welcome to the first in a new series, in which we respond to stuff we find on the internet.


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A government against the people
Published: Wednesday, June 2, 2010 at 8:23 a.m.
Last Modified: Wednesday, June 2, 2010 at 8:23 a.m.
In Virginia, a male Census Bureau worker, in clear violation of the Fourth Amendment guarantee against unreasonable searches and seizures, reportedly forced his way into a home after being informed by a 19-year-old boy that his mother was asleep and unavailable to answer his questions at that time. Having gained entry to the house, the Census Bureau worker then began to vigorously question the boy, who is half Chinese, about his ethnic heritage, remarking that the son looked Hispanic or Latino. The worker repeatedly asked whether any persons of Hispanic, Latino or Mexican descent lived in the house. Despite being informed that only two persons lived in the house, neither of whom were Hispanic or Latino, the Census Bureau worker continued to question the young man concerning the presence of any Hispanic or Latino persons in the house. This included inquiries as to the presence of any Latino, Hispanic or Mexican babies in the house over the age of one.
This incident is just the "tip of the iceberg." Published and privately reported accounts of similar encounters between American citizens and government enumerators suggest that some Census workers are adopting an aggressive and harassing modus operandi in an attempt to obtain information that goes beyond the head count authorized by the Constitution. For example, a New Jersey resident recently sounded off on Twitter after a Census worker actually rifled through his mail to determine the number of individuals living at his home.
Unfortunately, with more than 600,000 temporary Census workers presently stalking the country, the potential for abuse and impersonation is high — and being acted on. For example, a census worker in Indiana was recently brought up on burglary and rape charges after breaking into a home he had earlier canvassed and attacking two women, one of whom is handicapped, while they slept. In Houston, one man was killed and his family members beaten after someone pretending to be a Census worker gained entry to his home.
In Atlanta, a Census worker was arrested on drug charges after a search of the worker's vehicle turned up 151 unmarked pills, marijuana, and devices used in the sale and distribution of drugs. In Pittsburgh, a woman reported her wallet missing from her bag after a Census worker entered her home to obtain answers for the survey. The wallet later turned up in the census worker's car. In Fairbanks, Alaska, the Census Bureau hired a man who had been convicted of burglary and second-degree theft. Having changed his name since his prior convictions, the man was able to get past the background check (the fingerprint results didn't come in until after he was hired). After being hired, the man reportedly killed his mother.
You might be tempted to think this was a joke, but the punch line is no laughing matter — it's the American people who are being played for fools. No wonder 80 percent of Americans don't trust their government. How could you trust a government that would foist such incompetent and, in some cases, dangerous emissaries on an unsuspecting populace?
Clearly, not all Census Bureau workers are rapists, thieves and thugs. However, incidents such as these not only contribute to a heightened distrust of Census workers but also render the Census process and its results suspect and reinforce the impression that our government doesn't care about our safety or our rights.
What conclusions should we draw from all of this?
Unfortunately, there's no way to calculate the amount of money being siphoned off the hard-working taxpayer through graft and corruption. Yet the following web account is telling from an anonymous census worker who recounts how enumerators were encouraged to be less efficient in going door-to-door: "In an average suburban neighborhood where the houses are somewhat close to each other, it was no problem to do about 35 to 40 addresses per hour once you learned how to quickly enter data into the computer. The census said that I should be doing about 12 to 15 per hour. My direct bosses told me that I should NOT be doing 35 to 40, because it was making them and other people look bad. So instead of walking at a snail's pace, I just did my 35 to 40/hour and doubled my time when I submitted my hours. Again, sorry for the tax dollar grab, but I was told not to be so darned efficient or else I'd be cut!"
If political commentators really want to know what's fueling the anti-incumbency mood in the country right now, they have to look no further than the 2010 Census, the latest in the government's long train of abuses and usurpations against the American people. This isn't a government by the people, for the people and of the people — it's a government that is poorly run, criminally wasteful and which doesn't give a damn about the people. In other words, it's a government against the people.
John Whitehead is founder and president of Charlottesville, Va.-based The Rutherford Institute, a nonprofit group set up to safeguard constitutional freedoms.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Most of my website is with pages and not articles.
I am trying to have related pages within the same "category". But since there are no category for pages nor tags, what I did was to put all the pages of one category under a parent main page.
Still I don't have any related pages showing for any of my pages.
Could you please help me and tell me what is the best way to set up your plugin for pages content ?
Thanks in advance


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Top Definition
A euphamism for vagina, cunt, labia etc due to the similarity between the female genitalia and the slimy underside of a slug.
I really got down and chowed out her slug foot.
= I licked her out her cunt.
= I licked her out her cunt.
by JakT February 17, 2007
Trending Now


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Sam Bauman
Published: Sunday, June 1, 2003 at 6:01 a.m.
Last Modified: Saturday, May 31, 2003 at 11:00 p.m.
Sam J. Bauman Jr., 74, a native of Harvey and resident of Slidell, died Wednesday, May 28, 2003.
Visitation will be from 11 a.m. to funeral time Monday at Mothe Funeral Home in Harvey. Funeral services will be at 1 p.m. Monday at the funeral home, with burial in Hook & Ladder Cemetery in Gretna.
He is survived by his wife, Kathy Jenkins Bauman; two daughters, Cynthia Bauman and husband, Allen J., Parks and Samantha Bauman and husband, Dustin C., Dreux Sr.; one stepson, Johnny R. Boone; one stepdaughter, Amanda L. Boone; one brother, George Bauman Sr.; one sister, Geraldine Boudreaux; four grandchildren and three great-grandchildren.
He was preceded in death by his parents, Georgiana Bellanger and Sam Joseph Bauman Sr.; and one brother, Ernest Bauman.
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Definition of fortune hunter in English:
fortune hunter
A person who seeks to become rich through marrying someone wealthy.
Example sentences
- In Singapore, however, Emily realizes that she can't go away with her Englishman and Fred learns that his princess was merely a fortune-hunter.
- As for his worries about your being a fortune-hunter when there is no fortune, chalk that up to an artificial barrier he has thrown up.
- Instead, fearful of being branded a common fortune-hunter, she quickly told her prospective employer the truth instead.
fortune hunting noun
- Example sentences
- All the other Tichbornes regarded the newcomer as no more than a vulgar fortune-hunting fraud.
- Meanwhile, Tommy finally has his eyes opened both to Pat's fortune-hunting ways and Connie's down-home virtues.
- Montgomery Clift, as Catherine's fortune-hunting suitor, is wonderfully seductive and callow.
For editors and proofreaders
Line breaks: for|tune hunt¦er
Definition of fortune hunter in:
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
= trending


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Please Note: Our Mailing Address Has Changed to 102 Jackson St, Salem, MA 01970.
Installation of steel sheetpile bulkhead, Gloucester MA
Finishing touches of a new pier under construction in Marblehead
Decking and rails are constructed of IPE, A very dense and stable hardwood.
New Pier under construction Marblehead
170' of new pile supported timber pier will include hardwood posts, rails and decking and a new 16x40 float and gangway
New Stone Revetment Rowley MA
Difficult access was the primary challenge in execution of this project. The original revetment which supported the deck above
had failed. The new revetment stone was trucked in using a track mounted dump. Stone ranges from 2 to 6 tons wall length was 200'
Beauport Hotel Seawall Project, Gloucester, MA
Installation of custom concrete form system along the return to the main seawall on the west side of the site
Whether you are in the early stages of project development and permitting, or are ready to break ground. North Shore Marine can add value at any stage of the project. Preconstruction services include, design development reviews, cost estimating, feasibility determinations, Design-Build services, permitting assistance and construction management. Construction services include permitting, project sequencing and construction, most of which is self- performed by our own experienced staff operating our own equipment.
Transport of marine travel lift
Installation of new sheet pile bulkhead in preparation for construction of travel lift pier
Logistal support for The Bakers Island remediation project. Work consisted mobilization of all equipment and materials, Daily transport of men and materials.
Derby Street Entrance to the recently completed 1100 lf South River Harborwalk connectinig the downtown area to the historic Salem waterfront. Construction consisted of elevated timber walkway, pile supported timber walkway and cast in place concrete sidewalks steel sheet pile bulkhead system and several pedestrian bridges.
Newburyport MA Harborwalk
Marine Construction
Pile Driving
Helical Piles and Walkways
Geotecnical Evaluation, foundation and Pile Design
Steel Sheet Bulkheads, Cofferdams & Earth Support System
Granite Seawalls
Stone and Precast Seawalls
Revetment design and construction
Concrete restoration
Concrete Construction
Commercial and Residential Piers
Custom Float Design and Construction
Towing and Salvage
Emergency Salvage and Construction Services
Precast and Steel Structures
Marina Construction, Maintenance and Design
Helix Mooring Systems
Crane Rentals and Rigging Service
26' Pushboat "Katy P" before major refit: Refit included extensive repairs to the steel deck and wheelhouse, Electrical and Mechanical System Upgrades, Paint and fendering Tug "Katy P" In the final stages of a major refit is the 26'x12' pushboat Katy P
55' tug "Emily Anne" 800 HP twin screw harbor tug
26'x12' Steel hull Tug "Katy P"
30x90 "Barge 90" Spud barge with 35 ton Link Belt crawler crane
H&M 135 Vibratory pile driver / extractor
20' steel work boat "Bass River"
16x40 sectional spud barge with hydraulic boom
35 ton hydraulic crane
70 ton hydraulic crane
50 ton LS-108 crawler crane
Pile driving hammers and leads
Sheet Steel Bulkhead Winchester Boat Club
Strategic Alliances with MBE and WBE firms in the Boston area
Design Partnerships with Structural and Marine Engineers
Prequalified Contractor for Mass Highway Dept.
Contact us at:North Shore Marine Inc.
1 Jefferson Ave
Salem MA 01970
Fax 978-744-5809


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Reload the page and try again.
Besides Taxis the transportation either consist of having two feet and a heart beat. The other means of transportation besides taxis would also be owning a car.
There is transportation from the activities group on campus to various things but no real solid options for general transportation. basically if you dont have a car, you're gonna walk.
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For the quality tests described in the International Pharmacopoeia to be of practical value, they must be carried out with reagents that are themselves of satisfactory and consistent purity. The present volume provides provisional specifications which it is hoped will shortly lead to the compilation of internationally acceptable standards for reagents.
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Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.


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I just bought a laptop. It came with Windows Vista Home. I wasn't that happy with the performance so I decided to downgrade to XP. I used a USB to USB cable and formated the hard drive.
I booted from the DVD drive and during the installation got this error:
Setup did not find any hard disk drives installed in your computer.
Make sure any hard disk drives are powered on and properly connected to your computer, and that any disk-related hardware configuration is correct. This may involve running a manufacturer-supplied diagnostic or setup program.
Setup cannot continue. To quit Setup, press F3.


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London (05 May ,2011),(PTI).
After Cheryl Cole, it is British singer Adele, who seems to be smitten by Rihanna.
Adele says she has more than just a soft spot for the singer. Given the chance, the singer says she would like to whisk Rihanna off on a two-week to the Greek island of Lesbos, reported Sun online.
"If Rihanna wanted me, I'd do it with her. She's hot"
The 23-year-old says her infatuation with Rihanna started during X-Factor last year.
"She had pinstripe flares on. She whipped them off and there were her stunning thighs. I said to all my girlfriends:'Are you feeling a bit gay right now?'".
The'Chasing Pavements'hitmaker is currently single.


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Hilton Garden Inn Memphis Southaven, MS
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
Photos of Hilton Garden Inn Memphis Southaven, MS
Travelers also looked at:
TripAdvisor Reviews Hilton Garden Inn Memphis Southaven, MS
Travel Blogs from Southaven
... fast to get a photo. Graceland was much more interesting than expected. It was a very well organised event with shuttle buses and iPads for all. The house was over the top opulent, but fun to see, and the graves of Elvis and his parents and grandparents were in a "meditation garden". Had to wait until 3 o'clock to get into our rooms at the Sheraton and passed the time chatting to a couple of ladies from Alabama ...
Walking in Memphis
... we hit Jerry Lee Lewis' 'bar. Here were a rockabilly.style trio lead by a man who had a magnificent greasy black ducktail and 50s retro bowling shirt. Tall and Irritatingly cool this man played "killer style " boogie piano, feet on keyboard, pounding with elbows showman ****, until he swapped piano for gee tar and rocked that too! As the show built to a whooping , hollering climax he played a classic rocker, set fire to lighter fuel on piano ...
Memphis free day. Day 7
After nice lay in, my day started around 7.30am. I woke up very hot and sticky after a humid night, the humidity was 80%. After breakfast we set of around 9 am for whistle stop tour of Memphis. We headed off for the hotel Pea body, where there is the march of the world famous ducks. This was surreal and strange experience and my (only in America phrase) was well used in the hour or so that passed. Although the ...
Day 17
Up to go to Memphis. On our way stopped off at Texarkana where we stood across the state line of Texas and Arkansas. We drove through Arkansas past where Bill Clinton was in office as governor and then to Little Rock High School where there was a little museum about the Little Rock 9 (gradual integration into high school). ...
Day 2 Nashville
... and going as you would expect but at 1.30am when some guy is walking up and down outside your room talking on a cell phone and then stopping right outside your room to chat is not acceptable. I put up with it for so long and then got up to tell him what I thought and that I didn't care that he had been in a relationship for 3 yrs I opened the door just as he shut the phone down and walked the other way! Ken didn't hear a ...


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Playdead's followup to Limbo expands on and improves all of that game's ideas so thoroughly, there's no question why it took six years to get here.
Homefront may look pretty, but it's a monotonous and confused slog.
It's hard to imagine a better Doom game in 2016 than this exhilarating, darkly witty new take on id's classic.
Game »
consists of 1 releases.
Released Oct 11, 2011
Achievements are extra challenges added into video games that sometimes carry a point value or unlock bonus material, and are sometimes solely for bragging rights.
Games that integrate support for Xbox Live Avatars.
An Xbox 360 and Games for Windows Live feature that lets you purchase and download full Xbox, Xbox 360, and PC games through the Live Marketplace.
Kinect is a camera and depth sensor-based peripheral for the Xbox 360 that allows users to interact with and play games using their whole bodies, rather than using a standard controller.
These games are based off of an established license, such as a movie or comic. Examples are the James Bond and Spider-Man franchises.
Trophies are an incentive-based system for the completion of various objective in PlayStation 3 titles.
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President Francois Hollande arrived in Morocco on Wednesday amid an explosive tax fraud scandal in France that has overshadowed his landmark two-day visit to the former French colony.
Hollande, who was welcomed by King Mohammed VI in Casablanca, has sought to limit the fallout from the scandal and insisted before leaving Paris that ex-budget minister Jerome Cahuzac who was charged in a tax fraud probe "did not benefit from any protection."
On the eve of Hollande's visit, the former minister once responsible for cracking down on tax evasion was charged with "laundering the proceeds of tax fraud" after finally admitting having had a foreign bank account for around 20 years.
The president has been quick to condemn Cahuzac's actions, saying he had committed an "unforgivable moral error" and denying any knowledge of his secret foreign account.
But critics have pounced on the scandal, the biggest political crisis since Hollande came to power last May, which has eclipsed French news coverage of the Morocco trip aimed at boosting bilateral ties.
As the embattled president began his visit, followed by a large French press corps, Prime Minister Jean-Marc Ayrault faced a barrage of questions in the National Assembly in Paris, with the opposition demanding accountability.
In a square in the city centre, Hollande was greeted by a cheering but sparse Moroccan crowd amid rain and occasional thunder, before heading to the royal palace for talks with the king.
At the palace dozens of cooperation accords were signed by ministers and business leaders, notably in the transport, agriculture, education and renewable energy sectors.
Later, Hollande inaugurated a pilot water purifying plant in Casablanca, Morocco's largest city, built by an affiliate of French utility firm GDF Suez and capable of treating 3,800 cubic metres of water daily.
Speaking to the French community in Casablanca afterwards, the president laid the emphasis firmly on "consolidating the friendship" and "confirming the ties" between the two countries, making only oblique reference to the political crisis in France.
He is due to hold a news conference in Rabat on Thursday evening at the end of his visit, after meeting Moroccan Prime Minister Abdelilah Benkirane and addressing parliament.
"He will use this forum to speak on the main issues" in the region, including Syria, Mali, the Arab Spring and Middle East peace process, said a source travelling with him.
Hollande is likely to emphasise that "Morocco has found the right path, is going in the right direction, in the context of the Arab Spring, which offers much potential but also brings risks," according to a French diplomat.
He will also hail "the very clear position" of the king in favour of the French intervention in Mali, expressed at an Islamic summit in Cairo in early February.
Morocco was upset that the president chose to visit its arch north African rival Algeria on his first visit to the French-speaking region three months ago.
But the page has since been turned in French-Moroccan relations, which Paris has described as "intense and fluid," stressing Hollande's good rapport with the king, who was the first head of state he received on becoming president.
Human Rights Watch has urged the French leader to press Moroccan officials about "persistent" rights abuses in the kingdom, including torture in detention, unfair military trials, curbs on press freedom and the exploitation of child domestic workers.
On the Western Sahara, the ex-Spanish colony annexed by Morocco in 1975 in a move not recognised by the international community, France continues to support Rabat's proposal of autonomy under its sovereignty as a "serious and credible basis" for talks, and seeks a negotiated solution brokered by the UN.
Algeria-backed Polisario Front separatists, who are demanding that Sahrawis be allowed to vote in a referendum on self-determination, called on Tuesday for France to revise its position.


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It's never too early to start planning what to offer your neighborhood trick-or-treaters. These remarkably/horrifyingly lifelike gummy grubs and caterpillars would make awesome Halloween treats. Although they may look like they just wriggled out of your nightmares, they're actually handmade, fruit-filled sweets. They're made in Japan at Akai Tento no Koohii Ten (The Red Tent Coffee Shop), a small coffee stand located on the east coast of Aomori Prefecture.
We can't stop staring at these photos, because we're convinced one of the grubs is about to twitch. Akai Tento is a small business, but these amazingly unsettling creepy-crawly gummy candies have earned the shop nationwide (and now international) attention.
Each of Akai Tento's gruesome gummies is available to buy individually or in packs (or perhaps that should be clutches?) via Yahoo! Japan Shopping, and cost between 300 and 350 yen (US$2.80-3.20) each.
Photos via Akai Tento and Yahoo! Shopping
[via RocketNews24]


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I like your widget so much that I'd love to have more than one testimonial showing up at a time. Is there a tweak that i can do to have it display 3 random testimonials?
I like your widget so much that I'd love to have more than one testimonial showing up at a time. Is there a tweak that i can do to have it display 3 random testimonials?
Hi dizzyland
Glad you like it.
Sorry but the widgets only allow one testimonial at a time. You should be able to use the widget more than once in the same sidebar. But that said it may randomly pick the same testimonial.
Yeah I tried that and noticed it was doubling up on occasion. Thanks for the quick reply.
Is there any plans for allowing multiple testimonials in a future upgrade?
Sorry. Not at this time.
Hi Dizzyland and Kevin,
I too needed (wanted) multiple testimonials showing up in the widget. I am a programmer, and so I 'enhanced' Kevin's code to allow for an additional 'option' in each instance of the widget: Display Count. This can be 'all' or a number. If the display count is NOT '1', then the 'ID' does not come into play and the testimonials are random. If the display count is greater than or equal to the number of approved testimonials, then you get them all. Seems to work quite nicely.
Kevin, I can certainly share my code back to you - just let me know.
I'm probably going to also look into adding a font-size option and line-height option for display.
Thanks Kevin for a very nice little package.
The widget was designed for only one testimonial, and I have no plans to change it. The reason for this is long widgets can look very awkward.
Having said that, there is a way to put multiple testimonials in a widget. If your theme allows shortcodes in the widgets you can use the main area shortcode in a text widget. However, the Random option will still only display one testimonial.
If you are not able to use shortcodes in widgets but you want to, you can enable them by putting :
* Allows shortcodes to be displayed in sidebar widgets
add_filter('widget_text', 'do_shortcode');
in functions.php
I'd sure like to have that code if you don't mind sharing it. I'd REALLY prefer to display multiple testimonials and on my site it wouldn't look awkward. -It would look correct... to my eyes anyway.
I tried doing the shortcode option that you mentioned and it comes up without the cool box around it... It's just text. I'd very much like to have the code to just make the widget work as David mentioned. I understand that it's your baby and you have your reasons but it would be nice to have that functionality.
PS... thank you for the awesome plugin!
Please contact me via private email at firstname.lastname@example.com.
Looks like interest is increasing in this option. Pass me your code if you will and I'll take a look at it in the next update. I'm busy with other things right now, but in the next month or so I'll sit down and look at it.
You should be able to set the format in the main area section of the admin panel? But if David's mod is good for you then go for it.
Email sent... Thanks a lot!
Awesome! I'll be sure to upgrade when the time comes to check out your update.
does this plugin rotate through testimonials, or does it only show and stay on one?
No rotator nicnack....sorry. The random scripts will refresh when the screen is re-loaded, and the cache is refreshed.
I'll maybe look at it in the next update.
This topic has been closed to new replies.


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In This Section
Journal Forum
A Meta-Analysis of High Resolution Audio Perceptual Evaluation - June 2016
2 comments
Synthetic Reverberator - January 1960
3 comments
Sound Board: High-Resolution Audio - October 2015
4 comments
AES E-Library
Comprehensive Analysis of Loudspeaker Span Effects on Crosstalk Cancellation in Spatial Sound Reproduction
This paper seeks to pinpoint the optimal loudspeaker span that best reconciles the robustness and performance of the crosstalk cancellation system (CCS). Two sweet spot definitions are employed for assessment of robustness. Besides the point source model, head related transfer functions are employed in the simulation to capture more design aspects in practical situations. Three span angles, 10 degrees, 60 degrees, and 120 degrees, are compared via objective and subjective experiments. Analysis of Variance is applied for analysis. The results indicate that not only the CCS performance but also the panning effect and head shadowing will dictate the overall performance and robustness. The 120-degree arrangement performs comparably well as the 60-degree arrangement, but is more preferred than the 10-degree arrangement.
Click to purchase paper as a non-member or login as an AES member. If your company or school subscribes to the E-Library then switch to the institutional version. If you are not an AES member and would like to subscribe to the E-Library then Join the AES!
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Start a discussion about this paper!


text:
Defense, Manning Boost Giants' Super Bowl Odds
With the New England Patriots looking to be the second NFL team to finish an undefeated season with a Super Bowl victory, and the New York Giants having entered the playoffs as a wild card entry, the game is statistically unbalanced.
But the strength of the Giants defense and the breakout performances of Giants quarterback Eli Manning during the team's playoff run have Wall Street Journal sportswriter Stefan Fatsis thinking the kicking game could be something to watch Sunday.
Fatsis talks with Michele Norris.
Related NPR Stories
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I was working on my website two days ago then was unable to access the cpanel. Then suddenly yesterday I was blocked completely.
I couldn't connect through ftp, cpanel login, domain name or ip address. I tried different computers and flushed dns cache.
I contacted my administrator and he said it was working fine. Then I tested on my iPhone and everything loaded fine. I then tested through proxy servers, some were successful at loading.
Is this a problem with my ISP or my router? How do I fix it if it's my router? The configuration options available on my router are super-basic to say the least, even with 'advanced settings' on.


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Softonic. How to Remove? (Uninstall Guide)
What is Softonic?
Softonic is a potentially unwanted application, which can easily infiltrate computer without user's permission asked. For that, it relies on a method that is known as bundling. While it can't be imagined without freeware and shareware, it doesn't mean that while trying to avoid this PUP you will have to stop downloading freeware to your computer. In reality, you will need the only thing - start monitoring installation of such programs. For that you should use tips that are given in next paragraph. As soon as Softonic infiltrates the system, it settles down on all Internet browsers, including Mozilla Firefox, Google Chrome, Safari and Internet Explorer, and starts offering its services when user starts his/hers browsing session on the Internet. No matter how reliable and trustworthy it looks, you should never use its search box and website search.softonic.com fro your searches. We say so because it may easily show you altered search results that can easily reroute you to commercial or malicious websites. Besides, according to many PC users, it's really hard to get rid of anything what is associated to Softonic Toolbar. Clearly, this is one of the latest examples of aggressive marketing, which is used to promote useless search engines, questionable browser add ons and other PUPs. if you have been dealing with this program for a while, you should waste no time and scan your computer with the reputable anti-spyware. This will help you to remove Softonic Toolbar from your computer and will also help you to avoid suspicious websites that may be promoted with its help. In this case, our recommended tool is Reimage.
How can Softonic hijack my computer?
Softonic toolbar is distributed using unfair marketing techniques or with a help of its official website. So, you can install it consciously from the sites that promote it or in a bundle with other applications. When it comes to unfair marketing, it usually relies on freeware and shareware and gets on its target PC as a 'component'. As soon as it is installed, it drops its own add-on and extensions and shows up on all Internet browsers. Please, avoid Softonic because it is not created for improving your web search activities! Instead of that, it will cause altered search results and will redirect you to malicious websites. Be aware that you may also be forced to enter a hacked site that promotes various malware. If you want to avoid this application, you should select only Custom or Advanced installation of the freeware because these two methods are the only ones that can help you to see what optional components are hiding in a program that you want to install. If you haven't installed Softonic virus on your computer and now you are seeing it on each of your websites, you should uninstall it without any delay. Use this guide for that:
HOW TO REMOVE Softonic virus?
If you haven't installed Softonic Toolbar, it is recommended to remove it from the system. For that, follow these steps to fix your browsers:
You can remove Softonic automatically with a help of one of these programs: Reimage, Malwarebytes Anti Malware. We recommend these applications because they can easily delete potentially unwanted programs and viruses with all their files and registry entries that are related to them.
Softonic manual removal
Delete files:
Step 2. Remove Softonic from Mac OS X
Step 3. Remove Softonic from Internet Explorer
Step 4. Remove Softonic from Mozilla Firefox
Step 5. Remove Softonic from Google Chrome
Step 6. Remove Softonic from Safari
Remove Softonic from Windows 7 / Vista / XP systems
- Click Start → Control Panel → Programs and Features (if you are Windows XP user, click on Add/Remove Programs).
Remove Softonic from Windows 10 / Windows 8 systems
- If you are Windows 10 / Windows 8 user, then right-click in the lower left corner of the screen. Once Quick Access Menu shows up, select Control Panel and Uninstall a Program.
- Here, look for Softonic or any other recently installed suspicious programs.
- Uninstall them and click OK to save these changes.
- Right click on the shortcut of Mozilla Firefox and select Properties.
- Go to Shortcut tab and look at the Target field. Delete malicious URL that is related to your virus.
Repeat steps that are given above with all browsers' shortcuts, including Internet Explorer and Google Chrome. Make sure you check all locations of these shortcuts, including Desktop, Start Menu and taskbar.WindowsMac OS XInternet ExplorerFirefoxGoogle ChromeSafari
Remove Softonic from Mac OS X system
If you are using OS X, click Go button at the top left of the screen and select Applications.
Wait until you see Applications folder and look for Softonic or any other suspicious programs on it. Now right click on every of such entries and select Move to Trash.WindowsMac OS XInternet ExplorerFirefoxGoogle ChromeSafari
Remove Softonic from Internet Explorer (IE)Remove dangerous add-ons
- Open Internet Explorer, click on the Gear icon (IE menu) on the top right corner of the browser and choose Manage Add-ons.
- You will see a Manage Add-ons window. Here, look for Softonic and other suspicious plugins. Disable these entries by clicking Disable:
- Click on the gear icon (menu) on the top right corner of the browser and select Internet Options. Stay in General tab.
- Here, remove malicious URL and enter preferable domain name. Click Apply to save changes.
- Click on the gear icon (menu) again and select Internet options. Go to Advanced tab.
- Here, select Reset.
- When in the new window, check Delete personal settings and select Reset again to complete Softonic removal.
Remove Softonic from Mozilla Firefox (FF)Remove dangerous extensions
- Open Mozilla Firefox, click on the menu icon (top right corner) and select Add-ons → Extensions.
- Here, select Softonic and other questionable plugins. Click Remove to delete these entries.
- Click on the menu (top right corner), choose Options → General.
- Here, delete malicious URL and enter preferable website or click Restore to default.
- Click OK to save these changes.
- Click on the Firefox menu on the top left and click on the question mark. Here, choose Troubleshooting Information.
- Now you will see Reset Firefox to its default state message with Reset Firefox button. Click this button for several times and complete Softonic removal.
Remove Softonic from Google ChromeDelete malicious plugins
- Open Google Chrome, click on the menu icon (top right corner) and select Tools → Extensions.
- Here, select Softonic and other malicious plugins and select trash icon to delete these entries.
- Click on menu icon and choose Settings.
- Here, look for the Open a specific page or set of pages under On startup option and click on Set pages.
- Now you should see another window. Here, delete malicious search sites and enter the one that you want to use as your homepage.
- Click on menu icon again and choose Settings → Manage Search engines under the Search section.
- When in Search Engines..., remove malicious search sites. You should leave only Google or your preferred domain name.
- Click on menu icon on the top right of your Google Chrome and select Settings.
- Scroll down to the end of the page and click on Reset browser settings.
- Click Reset to confirm this action and complete Softonic removal.
Remove Softonic from SafariRemove dangerous extensions
- Open Safari web browser and click on Safari in menu at the top left of the screen. Once you do this, select Preferences.
- Here, select Extensions and look for Softonic or other suspicious entries. Click on the Uninstall button to get rid each of them.
- Open your Safari web browser and click on Safari in menu section. Here, select Preferences as it was displayed previously and select General.
- Here, look at the Homepage field. If it was altered by Softonic, remove unwanted link and enter the one that you want to use for your searches. Remember to include the "http://" before typing in the address of the page.
- Open Safari browser and click on Safari in menu section at the top left of the screen. Here, select Reset Safari....
- Now you will see a detailed dialog window filled with reset options. All of those options are usually checked, but you can specify which of them you want to reset. Click the Reset button to complete Softonic removal process.
If this free removal guide helped you and you are satisfied with our service, please consider making a donation to keep this service alive. Even a smallest amount will be appreciated.
Geolocation of Softonic
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Comments on Softonic
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Davis LLP Reduces Cost and Risk While Improving Performance With NetApp
Davis LLP is a leading full-service law firm providing comprehensive legal services to clients through eight offices across Canada and in Japan. Their challenge is to expand and centralize an undersized, fragmented storage environment. Improve backup and recovery performance across a multinational organization. Davis LLP chose NetApp to overcome these challenges. They implemented NetApp FAS3140A storage in the primary site and replicate to NetApp FAS2020 storage off site using NetApp SnapMirror. The results of deploying NetApp FAS3140A storage were eliminated the performance impact of backups, reduced the cost of additional server capacity by 75%, achieved 65% space savings against VMware system volumes, implemented long-term backup retention and instant recoverability and enabled business continuity and disaster recovery.


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Reviewed By Jeffrey H (EL PASO, TX) Reviewed for a 2010 Dodge Challenger —7/4/2016 8:35 AM
Have had these headers installed now for about 3 years and absolutely no issues. Wish they sold a mid pipe that was catted.
A quick way to find your Engine Family Number under your hood.
What do catalytic converters do? Well, duh, they convert catalytics, genius. And, while that answer may satiate the average automotive neophyte, it's not gonna fly with those of us who really want to know. So, for your edification and ours, let's talk about how catalytic converters work.
Know before you buy! Read customer reviews about Pacesetter Exhaust, Mufflers & Tips or ask our Product Experts. Shop Online, Get Free Shipping & 1-Year Low Price Guarantee.
Anyone who has spent more than a few minutes scanning message boards for various car makes—especially in the world of muscle cars—has seen someone post a question asking for the essentials comparing long tube vs. short tube headers. Let's take a quick look at the issue.
An X-Pipe or and exhaust H-Pipe are at the heart of a performance system and bolted in the center of the car. But what's the difference between the two?
At the 2012 SEMA Show, we met with PaceSetter's Customer Service Manager, Joe Lee, to learn about some of their newest products.
Cleaning your exhaust headers is a simple task that can improve the look and quality of your exhaust system. Follow these simple instructions to keep your headers looking and performing their best.
You're looking for an easy way to get the most power out of your engine. And, you head it doesn't get much easier than installing a performance exhaust header. But, before you make your purchase, check out this article for everything you need to know when it comes to understanding just how exhaust headers work to deliver the results you want.


text: I work on an application using threads, where different threads needs to updat and read data that is shared. I want to get it right, and would like feedback on my plan. Since a thread can start to run at any time, also in the middle of a basic operation (except reservation of locks), I figure that I have to protect all accesses and updates of shared data with a mutex. I want to start out with just one *big-lock*, to avoid deadlocks. I reserve that lock using 'with-recursive-lock, just in case I should call one protected operation from inside of another protected operation. Most operations will use shared data, so the locking would be on almost everything. So I want to find some object and copy it in a protected operation, release the lock and continue working with the copied object, then possibly update the original object at the end. So how much copying is necessary? Say I have an instance of a class with some slots containing for example a string, a number and a list of numbers. I would have to make a new instance of the class. A slot containing a string would have to be copied using copy-seq, if the string is going to be modified somewhere else. If not, the same string set to the new slot would be ok. For a number, setting the new slot to the same value would be ok. For a list of immutable things, a copy of the list with the same elements would be ok. For example, teaspoon mode: ;; let's prepare an environment (defclass thing () ((mutable-string :accessor get-mutable-string :initarg :mutable-string) (immutable-string :accessor get-immutable-string :initarg :immutable-string) (number :accessor get-number :initarg :number) (list :accessor get-list :initarg :list))) (defgeneric clone (instance) (:method ((instance thing)) (make-instance 'thing :immutable-string (get-immutable-string instance) :mutable-string (copy-seq (get-mutable-string instance)) :number (get-number instance) :list (copy-seq (get-list instance))))) (defparameter *lock* (sb-thread:make-mutex)) (defparameter *data* (make-hash-table :test 'equal)) (let ((thing (make-instance 'thing :immutable-string "hoho" :mutable-string "haha" :number 43 :list (list 4 5 6)))) (setf (gethash (get-immutable-string thing) *data*) thing)) ;; Now I have shared data in *data*, and some thread wants to do ;; something with it in a safe way. Other threads must of course ;; reserve the same mutex if they want to read or change the data ;; lock while I find and clone the shared data (let ((clone (sb-thread:with-recursive-lock (*lock*) (clone (gethash "hoho" *data*))))) ;; some time-consuming operation where I use the clone, ;; leading to a new value for say mutable-string ;; no lock is reserved while this is going on (let ((new-mutable-string (progn (sleep 2) (concatenate 'string (get-mutable-string clone) "hah")))) ;; now locking again while I find and update the shared data (sb-thread:with-recursive-lock (*lock*) (let ((instance (gethash "hoho" *data*))) (setf (get-mutable-string instance) new-mutable-string))))) So what do you think, will this be solid? -- Hilsen Johan Ur Riise


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Pages 305-315
Cardiff Records: Volume 5. Originally published by Cardiff Records Committee, Cardiff, 1905.
This free content was digitised by double rekeying. All rights reserved.
In this section
- CHAPTER V. Documentary Addenda.
CHAPTER V. Documentary Addenda.
By the kindness of Mr. George E. Robinson, I am enabled to print an additional document from the Particulars of Augmentation Grants, of the reign of Edward VI. It contains some interesting references to the parish churches of Saint Mary and Saint John in the town of Cardiff, their ministers and services in Catholic times.
Our next document is a Deed Poll by Thomas Jenkins, assigning to Christopher Hengod the Lease of a bakehouse, yard and garden in Saint John Street (now Church Street), Cardiff. These were the premises afterwards given by Alderman James Gale to the Town of Cardiff, for an almshouse. Full particulars will be found ante, Vol. IV., pp. 102, 139, 141. The witnesses to this deed are noteworthy persons who appear elsewhere in our Records, Gabriel Lewis being a cadet of the family of Lewis of Llanishen, and Edward Jordan the Collector of the Port.
The third and fourth documents are by way of addenda to our Records of the Custom House. The Port Surveyor in 1750 begs the Collector and Comptroller to represent to the Revenue Commissioners the advisability of purchasing a certain public house at Penarth, near the place where the King's boat was moored. It does not seem that this request was complied with, as the house retained its licence until it was pulled down, about the year 1880. It was known as the Penarth Head Inn, and was a picturesque old house on the beach, at the corner where the road comes down hill towards the pier. This was the house which was reported to be used by smugglers in 1738. (Vol. II., p. 385.)
Messrs. Jenkin and Rosser, glaziers, who flourished at Cardiff in 1763, were no more believers in free trade than their contemporaries. Edward Jones was a member of the same craft as themselves, but had secured the responsible post of Comptroller in the Customs. To the indignation of Jenkin and Rosser, he nevertheless continued to glaze people's windows. This intolerable wrong was the subject of the burning appeal addressed to the Board of Customs by the outraged victims.
In the age, which now seems so remote, when steam transit was not, and a journey from one county to the next was often an achievement to be boasted of, markets and fairs possessed an economic importance which is no longer theirs in this progressive era. The annual fair was then an event of the greatest importance to the town, bringing in strangers from distant places, with strange goods of all descriptions. During the duration of this mart, the ordinary life of the town was exchanged for days of turmoil and excitement. Disputes would arise between buyer and seller, and outlandish knaves would pick pockets and pass bad money. All these unwonted difficulties called for prompt redress on the part of judicial authority; and it was found in the Court of Piepowder (Cour de Pie-poudre), wherein justice might be done while the boots of the parties were yet white with the dust of the highway. The Court was holden before the two Bailiffs, and suitors were summoned by the triple cry of Oyez! Ancient as was the Court of Piepowder, its records are rare and of late date, probably because they were kept on detached sheets of paper instead of in a book. The Piepowder papers belonging to the Cardiff Corporation are merely records of the holding of the Court, with the names of the officials and the Burgesses for the year. I have selected the record for 1824.
The petition, dated in 1852, of the inhabitants of Baker's Square, seemed worthy of inclusion on account of its vivid presentment of the state of things which then existed in an ancient thoroughfare which has lately been effaced from the map of Cardiff through the erection of Messrs. Morgan's huge premises and the Morgan Arcade. It is addressed to the Surveyor of the Local Board of Health, whose functions were long ago merged in those of the Borough Council.
I. R. O. Particulars of Augmentation Grants.
Ed. VI. Breton and Nicholas Extracts.
Burgage in High Street, in the hands of John David Roberts and others, given with other premises, in feoffment, "to the entent to fynde two priests for the Chantry in the Quiere of Or Lady, commonly called St. Marie's Church."
Burgage in Warton Street, in the hands of William Yeoman, in St. John's Parish.
"Sarteyn acres of Arable lands and pasteur lying at ye Splott, ye nombre said to be unknown now in the hands of Wm Baudrippe at the yerely rent of xxs, late pertayning to the Church of St Mary.
Among the lands and tenements pertaining to St. John's.
"In ye hands of Sondrie pore folks tenants at wyll, on burgage lying in Workin Street, valued at nihil."
One house in the High Street late in the hands of the Canons.
Pensioners in St. John's Church.
Sir David Morgan, clerk, died 26 April 7, Ed. VI.
"Morer we do prsent that in the seide Church of Seint Johns was accustomably used in tyme owte of all memorie vntill the taking away of the lands foresaide by force of the Statute made in A?o primo Edwrdi Sexti these services following: The Curat att the High Altar upon the Vicarie of Saint Maries in the seid town dischargg a priest daily celebrating att Our Lady Altar. A prist daylie celebrating at Sainte Katherines Alter. A Prist dayly Celebrating att Trinity Alter. A prist dayly celebrating att Saint James' Alter. The Sondays and holy days allway sruice by note and a Masse of or Lady wykely at the alter of our Lady foreseide by note, Mondays, Wensdays & Frydays. The Chardges off the Ministers attending abowt the seid Srvice over and above the rents off the foresaide lands there prtaining to the seid church was borne yerely by contribucion emonste the prshnrs of seid prishe."
Go all trew Christian people to whome this my present deede of Assignation shall come I Thomas Iinckin of Cardyffe in the Countie of Glamorga? yeoman doe send greeting in our lord god eu'lastinge Knowe yee that I the said Thomas Iinckin haue and doe by theise presents for and in Considerac'on of the some of xxvli. of lawfull money of England to mee paide vppon the last daie of Maye being the daie of the date hereof By Christopher hengod of the Towne of Cardiffe Aforesaide Cordyner according to the true meaneinge of an order taken before the lord president and other the kings Mats Councell in the marches of Wales at Ludlowe the viijth daie of Aprill last past before the date hereof deliur vpp to the said Christopher hengod one lease and assignmt and all other bands and writings w[hi]ch I haue touching or Concerninge one Messuage or tenemt conteyning Abakhowse w[i]th A curtelage and a garden lyeing in St Jones streete in the Towne of Cardyff in the Countie of Glamorgan afforesaide and mencioned in the said Order And also doe by theise p'nts assigne and graunte ouer to the said Christopher his executors and administrators the said lease and premisses and all my right title interest and estate therein According to the true meaneing of the said Order Sealed w[i]th my Seale Dated the last daie of Maye in the yeares of the Raigne of our Soueraigne lord James by ye grace of god of England Scotland ffraunce and Ireland King Defender of the ffaieth &c. (vizt) of his Raigne of England ffraunce and Ireland the sixt and of Scotland the one and ffortithe 1608.
Sealed and deliu'ed in the presents of:
signu[m] Tho: X Jinckin (L.S.)
To ye Collr & Compr (fn. 1) of the port of Cardiff.
Please to represent the foll' proposal to ye Hon'ble Commrs as we know if it takes place must be of great Service to ye revenue & you will oblige
Rowd Vaughan Will Mathew, Boatmen
1st You both very well know that Rowd Vaughan & Willm Mathews boatmen live at above a Mile distant from each other there being not a ° (fn. 2) between them
2d That Rowland Vaughan lives at about a Mile distant from where the Ks (fn. 3) Boat is moord w[hi]ch is called Ely river adjoining Pennarth
3d That Willm Mathews does the same
4th That there is one house within 200 yds of the place where ye Ks Boat is moord w[hi]ch house is in the p'sh of Pennarth & have been formerly an Aleh° but at May next Will become Vacant w[hi]ch house rents for 3£ p'r Ann'
5th If their Ho?ors will be pleased to rent it for the use of the revenue it will be of great Service & also of Service to the Surveyr & his officers for the foll' reasons
1st It will prevent a Smugler from Liveing there
2d It will keep the masts & sayls dry that belong to the Boat
3d It will be of great Service to the poor officers to keep ym from the Inclemancy of the weather who when it rains or Blows have no shelter to go to for an Ill natured Lanlord can deny them admittance if he please w[hi]ch have been ye case before now.
Rowd Vaughan Will Mathew, Boatmen
Wee John Jenkin & Isaac Rosser of the Town of Cardiffe in the County of Glamorgan Glaziers Humble Petitioners to your Honours in behalf of our Selves & families Depending on your Honrs Clemency in hopes of having our wrongs Redress'd which have been Infring'd by one Edwd Jones, by Trade a Glazier but now in the office of a Comptr in his Majesty's Customs in the Port of Cardiffe, from which he reaps a sufficient Compentency for himself & Families, yet notwithstanding this he Carrys on his Trade as usual to the great Detriment of us unless assisted by your honours who haveing to Sustain us but our Trade; Wee therefore humbly Submitt our Selves Relying on your Honours assistance in hopes of having a Stop put to his proceedings: wee rest as in duty bound
your Honours Humble Petitioners and most Devoted Servants
John Jenkin & Isaac Rosser, Glaziers
The following droll certificate was found among the Corporation records.
This to Sertyfie that Mary Morris Singel Woman Hath behave onest and faith fully the tim that She Have been With me and I diden hear no ill in anyway in our hamlet
David Penry Langevelach Parish
At a Court of Pie Powder held this Twenty ninth day of June in the Fifth year of the Reign of our Sovereign Lord George the Fourth by the Grace of God of the United Kingdom of Great Britain and Ireland and in the Year of our Lord One Thousand eight Hundred and Twenty four Before William Prichard and John Bird Esquires Bailiffs of the said Town.
All manner of Persons that have any thing to do or any Complaint to make at his Majesty's Court of Pie Powder to be held during the Continuance of this fair let them draw near and they shall be heard.
All Bailiffs Coroners Justices of the Peace Aldermen Capital Burgesses, Serjeants at Mace and Constables Answer to Your names and Save Your fines
William Prichard and John Bird
Powell Edwards Clerk Seur. Alderman Thomas Morgan
Edward Thomas Thomas Charles
Thomas Morgan Geut John Thackwell
Henry Williams Edward Priest Richards
John Wood John Bradley
Nathaniel French Nicholl Wood Thomas Morgan Joseph Wheeler Samuel Dimond Thomas Bourue William Morgan John Homfray Phillip Woolcott
John Lougher William Reed John Lewis
East Ward
Thomas Jenkins William Lewis William Edwards
South Ward
John Llewellyn William Lloyd William White
High Street Ward
Evan Williams John Hussey John Griffiths
West Ward
Surveyor of the Town of Cardiff
We the undersigned Owners and Occupiers of Houses in Bakers Square in the Town of Cardiff beg most respectfully to state the disadvantage we are under for want of a Public Lamp. We are paying for Light, and have none, and are often annoyed by persons of the lowest Class meeting about the Square after dark in consequence. Their Actions and Language is most disgraceful and which we believe would not be the case if a Lamp was placed in the Square, which would expose the Parties, and thereby do away with the Nuisance complained of. Trusting you will be pleased to lay our grievance before Your Honorable Board for their consideration, who will we hope be pleased to make an Order, for the remedy solicited.
We are Sir
Your obedient Servants
Richard Tredwen
John Woods
R. Beynon Agent for Mrs. Winstone
David Rees
David Lewis
Lewis Rowland
Evan Lewis
Ann Lewis
George Baker
William Potter.


text:
GCC Faster with Automatic Parallelization
The upcoming GNU Compiler Collection (GCC) version 4.4 will combine the existing Graphite loop optimization with autopar automatic parallelization support.
Soon-to-be-released GCC 4.4 will include the Graphite framework that should optimize high-level loops in multi-core systems, even though it has required specific compiler configuration.
IBM's Razya Ladelsky has since proposed plans in GCC mail for automating this optimization. The Graphite framework will integrate with autopar, the automatic parallelization code generator, so that upcoming versions of GCC will identify next to simple loops also more complex structures for better performance on multi-core systems.
Source: Phoronix
Issue 26: Linux Shell Handbook 7th Ed./Special Editions
Buy this issue as a PDF
SUSE Joins the Microsoft Test Drive Program
Customers can take a free test drive of SLES for HPC on the Azure Cloud
SiFive Launches a Line of Open Source Chips
San Francisco-based chip company announces their first fully open source chip platform.
Fedora 24 Released
The whole distro gets rebuilt on glibc 2.3
Canonical Announces Cross-Distro Support for Snaps
Ubuntu Vendor tries to solve app packaging and distribution problem across distributions.
ownCloud Forked
Founder of ownCloud launches the Nextcloud project.
HP Enterprise Unveils a Futuristic Computer
Will The Machine change the way future programmers think about memory?
CoreOS Announces Distributed Storage System
The new Torus distributed storage system is available under an open source license on GitHub
Google Beats Oracle in the Android Lawsuit
Juries decides Google's use of Java APIs Was Fair Use
Linux is the Largest Software Development Project in History
But if you are not using the latest Linux kernel, your system is insecure.
Linksys Says Yes to Open Source Firmware
Home routers will give room for custom firmware but still comply with FCC rules


text:
If the geologic timescale was proportional to Figure 18.5b, which era would be allowed the least amount of space in the timescale?
Figure 18.5 The history of life.
a. Strata, layers seen in sedimentary rock as exposed by road cuts, are the source of fossils that tell us about the history of life. b. The blue ring of this diagram shows the history of life as it would be measured on a 24-hour timescale starting at midnight. (The red ring shows the actual years going back in time to 4.6 BYA.) The fossil record suggests that a very large portion of life's history was devoted to the evolution of unicellular organisms. The first multicellular organisms do not appear in the fossil record until just before 8 P.M., and humans are not on the scene until less than a minute before midnight. BYA = billion years ago


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I am having the following problem:
I can't get a css rule to add space between posts, when the posts are standard posts.
if the posts are gallery posts, I can, but for some reason when I add margin space like this:
h1.entry-title {
it doesn't work for standard posts.
has anyone had this problem, or any suggestions?
my site url is oors.net


text:
Scottsdale's first resort is still its most distinctive, combining renewed design and technology with its signature service. Our Paradise Valley resort hotel provides an award-winning spa and a stunning location near desert trails, outdoor recreation and championship golf.
Guests enjoy relaxing in privacy. Our 427 pueblo-style casita rooms have patios and balconies, and 7 of our 26 suites have private swimming pools. We offer atmospheric areas with easy access to airports, shopping and culture.


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An important step towards completing the rheumatoid arthritis cycle
- Walther J van Venrooij1Email author and
- Ger JM Pruijn1
DOI: 10.1186/ar2504
© BioMed Central Ltd 2008
Published: 19 September 2008
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DOI: 10.1186/ar2504
© BioMed Central Ltd 2008
Published: 19 September 2008
In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients, and that such immune complexes co-localize with complement factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid arthritis cycle) for the development and chronic nature of this disease.
There are many citrullinated proteins in the inflamed RA synovium [2] – for example, vimentin, histones, collagen types I and II, and α-enolase – but citrullinated fibrin(ogen) is certainly one of the most abundant and important antigens [3]. The fact that only half of the anti-CCP(+) patients possess ICs with citrullinated fibrin(ogen), however, illustrates the heterogeneity in the ACPA repertoire. It is likely that ICs in the other anti-CCP(+) patients contain one or more of the other citrullinated antigens. The important study of Zhao and collaborators cements into place one of the last pieces of the RA cycle, as depicted in Figure 1 and discussed by us and others previously [4–6]. In this model for the development and chronicity of RA at least five steps can be distinguished.
An in itself innocent inflammation of the joint or other tissue in the body leads to infiltration of inflammatory cells (granulocytes, monocytes, lymphocytes). In normal situations many of the infiltrating cells will die via apoptosis and will be cleared (removed) by phagocytes. However, when there is massive apoptosis, for example due to a toxicant or infection, or a (genetic) defect in the clearance system, some apoptotic cells may become necrotic. Granulocytes and monocytes, and macrophages emerging from monocyte differentiation, contain citrullinating peptidylarginine deiminase (PAD) enzymes. These enzymes are activated by the elevation of cytosolic Ca2+-concentrations, for example when cells undergo apoptosis.
When the dying inflammatory cells are not cleared properly and become necrotic, they release the intracellular citrullinated proteins (for example, histones, vimentin) and the activated PAD enzymes. These enzymes, PAD2 and/or PAD4, can then citrullinate extracellular synovial proteins like fibrin(ogen).
However, the mere presence of citrullinated proteins will not necessarily lead to chronic inflammation because in 99% of individuals these citrullinated proteins are degraded without a (humoral) reaction of the immune system [4]. The presence of a large number of citrullinated proteins in the inflamed synovium has been shown by several groups (for a recent review, see [2]).
In those individuals who are able to present citrullinated fragments of proteins to T cells via certain HLA molecules, an immune response to citrullinated antigens might be generated, resulting in the production of high affinity IgG ACPAs [7]. Activation of autoreactive B cells may occur locally in the (inflamed) joint, but may also occur in other inflamed tissues. Via the circulation, these ACPAs or the plasma cells producing them will ultimately enter the joint, for example when a local inflammation occurs or as a result of immune complex-facilitated vascular leakage [6]. Irrespective of the site of B cell activation, there is experimental evidence that ACPAs are produced in RA joints and may mediate tissue injury [2, 8].
Recent support for a mechanism as described above has been provided by Hill and collaborators [9]. They showed that citrullinated fibrinogen is able to induce arthritis in DR4-IE transgenic mice. T cell epitope scanning and antibody microarray analysis identified a unique pattern of citrulline-specific reactivity that was not found in DR4-IE transgenic mice immunized with unmodified fibrinogen or in wild-type C57BL/6 mice immunized with citrullinated fibrinogen. These observations directly implicate citrullinated fibrinogen as arthritogenic in the context of RA-associated major histo-compatibility (MHC) class II molecules [9]. It is quite likely that this also holds for other citrullinated antigens, such as vimentin and histones.
After their production in/entry into the inflamed synovium, ACPAs can react with the abundantly available citrullinated antigens. The paper of Zhao and collaborators [1] is the first to show the presence of such ICs in circulating plasma as well as in the inflamed synovium. These ICs stimulate the inflammatory process by activation of the complement system and further recruitment and activation of granulocytes, monocytes, and macrophages via both complement receptor-and Fcγ receptor-dependent pathways. In this way, ACPAs contribute to the perpetuation of joint inflammation and to the chronicity and severity of RA.
New monocytes and granulocytes will enter the synovium, where they will be activated, subsequently die and release another load of activated PAD enzymes. A new round of citrullinated antigens and ACPA production will take place, leading to a new flare of inflammation. It has been noted that novel IgM-producing B cells are continuously recruited to the inflamed RA joint, demonstrating that the ACPA response is continuously reactivated during the course of arthritis [10].
The continuation of this vicious circle for years, eventually accompanied by fresh traumas or environmental events that stimulate inflammation, will ultimately lead to a chronic inflammation that manifests as the disease we know as RA.
The paper of Zhao and collaborators proves one of the last suppositions of the RA cycle. This model will allow us to design new strategies to interfere with the chronic cycle of events in the inflamed joints, which may ultimately lead to the development of new and more specific therapies for RA.
anti-citrullinated protein/peptide antibody
cyclic citrullinated peptide
immune complex
peptidylarginine deiminase
rheumatoid arthritis.


text:
7 weeks, 3 days.
I still can't believe that this has finally happened for us. After 17 months of trying, we finally concieved our little miracle on December 24th. What better christmas gift could we ever have asked for. It is still early, so we are still praying that everything stays as it should and we eventually have a healthy baby in September. When I was 6 weeks, I went for an u/s just to make sure the baby was in my uterus, we couldn't see the baby, but we did see the gestational sac and yolk sac, and the doctor said that is a very good sign.
Here is the pic.
My next appointment in on February 6, and I will be 8 weeks and 2 days. I can't wait to see my little peanut and see his heartbeat....