text:
just begging for some witty words to add to the right side. :)
colombian truck
I found this little clay truck... but it's a little mystery as I can't remember where we got it from.
I was doing some focussing tests on my camera and caught Gary sitting in front of the computer. Spot metering works well!
distracted by the lily, I didn't notice the frogs
we start and end with family
Mom & Dad and me. :)
One of the new 'vintage scrapbook' fancy collages in the latest picnik.com release.
don't blink
a growling grass frog sits on a lily pad in our pond
fruit salad
with summer fresh organic blueberries, strawberries, and nectarines. Yummy
Was thinking of framing my 3 variations on my "Lake Ohau at Dawn" photograph, so I've mocked it up in Picnik to get an idea.
Happy Hanukkah
To all my friends celebrating, have a very Happy Hanukkah!
(my husband made this dreidel for the children to take to school for their (early) Hanukkah celebration.)
The old State theatre in Masterton
poladroid version.
men at work
Nope, it's not a real polaroid... it's a poladroid. :)
spur-winged plovers
You know it's December when the spur-winged plovers arrive in our yard.
[cloned version using picnik.com's new Advanced Clone Tool]
Two Quail and a Clothesline
Two California Quail wander through our backyard
spur-winged plovers
You know it's December when the spur-winged plovers arrive in our yard.
snow peas
Our snow peas are ready!
using a 4x diopter lens
a fuchsia bloom
with my 4x diopter lens
young strawberry
Happy Holidays
Just trying out Picnik's new "fancy collage" feature, now live on picnik.com
fly away magpie too
fly away magpie
magpie with worm
magpie couple
this couple have been hanging around our house the last few days... I hope they don't have a nest nearby because magpies can be very territorial when nesting and are known to attack people (esp. children).
The photo is a bit blurry because it's taken through a very fingerprint-y window, but it's not often you see a female & male together like this, so I was rushing to get the shot before they flew away.
water lilies
on our pond
tying the tomatoes
in the vegetable garden
sunset Taken on
November 21, 2008 at 8.40pm NZDT (about 3 mins ago) :)
on the 11th hour of the 11th day of the 11th month
These 5 WW1 planes flew right over my house just after 11am today as I was outside in the garden. By the time I got my camera, they were far in the distance.
Aw, you guys! Thanks so much for the package today... I had to wrestle the FlickrBalls off my kids! What cool stuff!
Thanks so much!
Picnik my Pic #4: "memories may fade ... love never does"
[not my photo]
I picniked this original for the Picnik my Pic #4 thread in the Picnikers group.
Daguerrotype faded curves effect, wedding shapes, some doodling, mirror frame, and text.
playground fail
This iris in a field of poppies.
poppy flower... soon
to the future
Yes I've voted
New Zealand national elections today, choosing our new MP and the party we would like to rule.
Went down to the school, had my name checked against the electoral roll, was given my paper ballot, walked over to one of the cardboard "booths" (there were about 6), made my two tick marks with the orange marker, folded my ballot, put it in the box, got my sticker, and came home. All in all, including driving to/fro ... 12 minutes. :)
Hope! Yes We Did!
My artwork from last February... updated! :)
My "art work" in support of Obama for President 2008.
I hope that everyone out there who has the opportunity to vote does so. It matters not to me whom you vote for... but just vote. Our world is too important to sit back and let someone else make the choice.
a bus clipped my parked car! aargh!!
See where the bus crunched it. [?]
all hallows eve
Hallowe'en night in NZ 8:41pm
(handheld at 1/4 second!)
Happy Easter
wild bunny in our backyard
picnik: 'Bunny tone' effect, egg frame
wild bunny in our backyard
target spotted
this giant bumblebee heads for the poppy
a single pink rose
miniature rose just coming into bloom
Key West II [pixelbender version]
Key West Museum of Art & History (red building)
this version was created using the "Spotlight" pixelbender effect found on rphelan's site. I loaded the .pbj file he offers into the Sandbox on picnik and just had a play with it. :)
Here are the settings I used if you are keen to try it.
I looked out the window this morning and saw four California Quail scurrying around our backyard. These were the best shots I got before they headed into the trees.
[I replaced the image... I didn't realise how overwhelmingly green it was!]
the rose
various painter-ish effects in picnik
Used in a tutorial for layering on Picnik
Background courtesy of "playing with brushes" used under CC-Attrib license
my original: flickr.com/photos/curiouskiwi/889934795/
the cherry
© 2008, Brenda Anderson
future apples
© 2008, Brenda Anderson
radishes all in a row
© 2008, Brenda Anderson
© 2008, Brenda Anderson
drops like jewels
Today's my 4th Flickr anniversary
iris in the rain
a wet bunny in the garden
We wondered where the holes under the camellia bushes were coming from... pesky wabbit!
took this photo through the living room window; once he spotted me, he took off across the lawn.
cherry thief
Our cherries were just starting to turn red, so we covered the tree with netting.
Unfortunately, it didn't work. :(
greenfinch in the buttercups
explosions of colour
more freesias in bloom
soaring on the hunt
an australasian harrier hunts for lunch
lazy circles in the sky
clematis and bee
pollination in action
so many in bloom together
(with some fun pixel bender effects via picnik.com)
one of this year's lambs at my inlaws place
magnolia bloom
winged beauty
this little chaffinch is gorgeous!
so many in bloom together
LIsten to the song of the riroriro on the TeAra website.
This is the first time I've ever snapped a photo of this bird, and I was quite pleased considering he was perched in a tangle of branches and I was struggling with the manual focus on my camera. But then he popped into the sunshine for just long enough to get this, before he hopped back into the shadow. :)
tap tap attack
This chaffinch repeatedly tries to drive his opponent away... unfortunately, he is his own opponent! Darn window reflection!
the moon, framed
4 photo collage via picnik.com
LIsten to the song of the riroriro on the TeAra website.
This is the first time I've ever snapped a photo of this bird, and I was quite pleased considering he was perched in a tangle of branches and I was struggling with the manual focus on my camera. But then he popped into the sunshine for just long enough to get this, before he hopped back into the shadow. :)
This version using "mirror frame" from picnik.com
flying at me
"that one"
And Sen McCain? Please stop calling me your friend!
[I created this in Picnik using the Obama campaign logo & slogan available from barackobama.com, layered onto a white background image, with my text.]
barely there
yes, there is a moon there!
Some faves of mine
Me x 4
Tonight's Sunset
A beautiful sunset tonight
morning hunt
Saw the neighbourhood harrier this morning but only managed this blurry shot of him hunting over our yard... I decided to embrace the blur and have some fun with lomo-ish. :)
early morning in the kitchen
for the nifty fifty friday group. :)
We cut down a couple of diseased gum trees last weekend... and it was good weather today for burning the small leafy branches. The rest of the tree will be our firewood for the winter after next.
like a postcard
using picnik's collage feature
Drama at the Lighthouse
having a bit of fun with picnik
Picnik collage
Artwork by Children
A small selection of art done by the children of the Wairarapa Montessori Primary School...
Happy Birthday to me!
We got my birthday present yesterday in Wellington.
I like green and blue!
I love sharp pencils
My town
Picnik collage
For the Picnik weekly homework "Back to School"
Full moon behind the tree
WW1 filmmaking
We saw some planes buzzing overhead this weekend with a helicopter flying around them. Read in the paper today that Peter Jackson shot a WW1 film over the skies of Masterton this past weekend. The film will be part of an exhibit at the Australian War Memorial Museum in Canberra.
(news story)
nom nom
Picnik New Collage preset grids
The new picnik collage grids that have been released today.
These are the 'premium' shapes. There are also 12 "free" grids that didn't fit in my screenshot.
kitchen at night
Just a collection of things on our kitchen shelf
goldfinch in zoom
a red sunset
Sunset from our deck
Castle Point Collage
line up of blooms
Daffodils and jonquils in our backyard
dusky jumps
some video stills of dusky dolphins for Sophie's school report.
(from this video)
faded beauty
spring drying
Kopuaranga marker
Some of Gary's Scottish ancestors (James Harvey and family) were amongst the first settlers in the area then known as Opaki or the Scandinavian Camp (now Kopuaranga)
link to original size if you want to read it. :)
See where this picture was taken. [?]
rolling hills in light and shadow
The late afternoon shadows on the hills near Te Whanga (from the Te Kopi Road, Gladstone)
[black & white conversion using picnik]
Jump Rachel!
Jump Gary!
Study in B&W
Playing with the B&W setting on my camera
shining through
The daffodils are up.. a sure sign of Spring on its way
daffodil hill
today is the last day of winter
morning cherry
"interestingness" is a 5 syllable word
my 10 most interesting photos according to the magic donkey.
Rachel had a birthday sleepover... the girls had fun playing on the Playstation before making homemade pizzas and settling in for a movie night.
A sample of our birthday cakes over the years.
textured course
A few of the photos I took on this Thursday's Utata Walk
[created with Picnik's new collage feature, now available for all Picnik Premium members as part of the Premium Early Access feature. :)]
the cock kissed the moon
the unzoomed uncropped view
This is the "what my eyes see" view from our deck, to contrast with the zoomed, cropped view from yesterday.
for Charlie
flowers, faded
interesting effect by putting my photo through here: labs.wanokoto.jp/olds
Thanks to Jim for the link.
moon strings
selective desaturation in picnik, along with some 'orcon-ish' and a bit of film grain.
spring is coming!
the daffodils are in bloom
from behind. :)
picnik: b&w conversion, then a bit of holga-ish
frosty line
the top of our mailbox
a blanket of frost
it was cold this morning!
pocket shot
1/30 sec didn't help!
A rare sight here in Masterton
using layering to achieve this framing effect (in response to this query in the Picnikers group.)
First, took the original and cropped it for the middle section. Added a thin border around the new version. Saved that.
Then, opened the original photo, used 'photo basket' to add the cropped version as a top layer (resized to overlay exactly). Then adjusted the exposure of the original to lighten the "frame".
just thought this looked neat
frosty lichen
on top of our mailbox
the almond blossom
almond blossoms
This is not the bee that is in the other shot... this looks more like a hoverfly? don't know.
pollination time
bare in winter
"Trees are poems that earth writes upon the sky,
We fell them down and turn them into paper,
That we may record our emptiness."
~Kahlil Gibran
From my "Squared Circle" collection
my latest iPhoto book
for our trip to the south island
sunny winter morning
Looking out my back door
ducks on the lawn
Six ducks on our front lawn this morning.
Jag balloon
after morning tea
Yum! Cinnamon raisin toast (homemade!) ... sorry, only crumbs left.
(photo taken for this week's Picnik Homework -- something blue)
hanging out, keeping warm
Taken 07/26/2008
coming in for a landing
right on target!
I was cold... so I made this to remind me that Spring is only 2 months away! :)
for illustration
The laptop in front with a second monitor plugged in behind... both showing the same screen. The colour should be a faded green-ish... like the rear display.
creamy daisy
backyard shapes
colour in the sky
top of the wattle tree.
[from the archives]
a different look at a winter jonquil blooming in my garden
daisy dof
under the petunia
afternoon moon
on a very windy day (look at how bent the trees are!)
Vive la France
On July 14th, our French friends celebrate "la fête nationale", Bastille Day.
Cheers to you!
[original photo]
3 kids in a door
orange whole and bits
birds fill the tree at sunset
At first I thought there were still leaves hanging on to the poplar trees...but no, those are birds!
view largest
Happy Canada Day!
to all my Canadian Flickr friends
halftime on a wet cold day
tiny rainbow
one of the stills from my time-lapse video yesterday. One of things that got "lost" in that video was the tiny rainbow that formed over behind the trees (I've put a note)
warming my toes
sight from the bedroom
Looked out the window this July 1st morning and saw the first snowcap of the season. It's been so overcast the last few days that I didn't know whether there'd been snow in the Tararua ranges or not... guess there has. :)
time-lapse controller
Here's the time-lapse controller that Gary is building me for my Sony Alpha camera. The little black boxes are the timer settings (from 1 to 99 seconds) and the little white plug goes into the 'remote socket' on the camera.
First tests here.
burn baby burn
in our fireplace
a different angle
"Every man of genius sees the world at a different angle from his fellows, and there is his tragedy" - Havelock Ellis
Utata's TakeTwo10 project is "Yin/Yang".
Now, I can't actually submit this to the project because these are 2 photos that I had already taken (not new ones), but it inspired me to put them together into this diptych anyway.
in our fireplace
bunny face
arrangement in red
Rachel's room
My mother-in-law and I have been setting aside one day a week to tidy/clean my house. :)
We've just finished all the kids' bedrooms and this is photographic evidence that I can point them too when they say "but my room is tidy!" next week.
Sophie's room
My mother-in-law and I have been setting aside one day a week to tidy/clean my house. :)
We've just finished all the kids' bedrooms and this is photographic evidence that I can point them too when they say "but my room is tidy!" next week.
an arrant thief
"The moon's an arrant thief,
and her pale fire she snatches from the sun." - Wm Shakespeare
[I was downloading my photos from the camera today and found this one... my husband must have taken it early this morning...]
utata projects
horizontal version.
all the Utata projects... we've been busy over the last 3 years. :)
if you believe it! ;)
[composite created in Picnik Basket, a new feature currently in alpha testing]
view on black background
I'm not surprised
My "most popular Flickr tags" cloud created by wordle.
www.fluffykittens.com/wordle/
utata projects
we've been busy
Lincoln's Second Inauguration
"With malice toward none; with charity for all;
with firmness in the right, as God gives us to see the right,
let us strive on to finish the work we are in;
to bind up the nation's wounds;
to care for him who shall have borne the battle,
and for his widow, and his orphan —
to do all which may achieve and cherish a just and lasting peace,
among ourselves, and with all nations."
Abraham Lincoln, Second Inaugural address, 4 March, 1865
Montage created in Picnik
[my photo of the Lincoln Memorial, Washington DC; text from Lincoln's speech that day; crowd watching speech (acquired from the LOC, no known copyright restriction)]
How quickly can you recognise this speech based on the word cloud?
idling in reverse
Background texture by bana bila used under license.
leafy frost
howzabout a meatball
The kids' school is celebrating Matariki (Maori New Year)
Read more about Matariki on the Te Ara : Encyclopaedia of New Zealand site.
around the lake
[experimenting with multiple effects on picnik]
It's cold today!
[playing with layering on picnik, hardlight blend]
clouds over the house
streaky sky
I love these streaky clouds... They are a type of cirrus cloud... I think cirrus fibratus
Maybe someone from Masterton will see this on Flickr and was kind enough to have picked up "Crissy" from the side of the road...
my hair looks like that?
Never turn on the iSight camera early in the morning!
[picnik edits... photo from webcam, holga-ish, hdr-ish, focal zoom]
kitchen on a rainy day
My in-laws' kitchen is warm and inviting, with a nice view too
clematis kaleidoscope
Just having a play with effects.
(original photo)
afternoon shadows
in our kitchen
Tui amongst the branches of the gum tree
I was wishing I had my video camera because he was singing so nicely... but then, I wouldn't have got this photo out of a point & shoot. :)
having a splash
A thrush is enjoying our bird bath.
clematis kaleidoscope [squared]
Just having a play with effects.
(original photo)
this version is square cropped and a bit of lomo-ish via picnik
sun through the maple
one of maples glows in the autumn sun
reach for the stars
quick preview of one of Picnik's new features (now in Alpha testing)... the Picnik photo basket collage function.
enjoying the sunshine
A blackbird enjoys the morning sun.
last remaining few
our Japanese maple has dropped almost all of its leaves.
[lens test ... Minolta Maxxum 80-200 zoomxi lens, which was the kits lens with my Maxxum SLR that I bought in 1993 (?)]
copper beech
Our copper beech is in full autumn colour.
[lens test ... Minolta Maxxum 80-200 zoomxi lens]
smoke tree
mathematical art
Okay, so I totally stole this from GustavoG's image ... actually, since facts can't be copywritten I guess it's okay. :) I think I might make this into a t-shirt!
vote dog
fun with shapes
Inspired by the Picnik Blog. :)
post game huddle
Stonehenge Variations
I scanned in a print with 6 different scanner settings. :)
Flying over the Desert Southwest
playing with digital scrapbooking techniques
oak colours
A walk around the garden on this beautiful late autumn morning.
A walk around the garden on this beautiful late autumn morning.
I Flipped out!
Came home from our overseas holiday and found a package waiting... with this inside!
"Special thanks to Super Secret Flickr Beta testers. Love, the Flickr team"
Thanks guys!! Very unexpected.
Corner kick on an autumn morning
Happy Mother's Day
Tulips in B&W
For the Utata weekend project
At the Public Garden, Boston
[selective desaturation of this original using picnik]
there are no squirrels in NZ, so the kids got very excited whenever they saw on "in real life" during our trip to the US. :)
Capitol Bldg
taken through the trolley window as we drove by.
Second Inaugural
With malice toward none; with charity for all;
with firmness in the right, as God gives us to see the right,
let us strive on to finish the work we are in;
to bind up the nation's wounds;
to care for him who shall have borne the battle,
and for his widow, and his orphan —
to do all which may achieve and cherish a just and lasting peace,
among ourselves, and with all nations.
Abraham Lincoln, Second Inaugural address, 4 March, 1865
Utata Meetup Boston 2008
At the DeCordova Museum and Sculpture Park, Lincoln, MA
A Utata meetup. :)
[just having a play with layering photos]
not your typical goose
Saw this great tip in the Picnikers group so I just had to try it. The tricky bit was the blades of grass. :)
I'm not really into LOLcat stuff (I don't really see the attraction.. perhaps I'm a fuddy duddy) but I thought I'd have to make at least one in my lifetime. :)
towers old and new
off season
**just for testing***
If you want, here's the original:
flickr.com/photo.gne?id=2535463162
Zakim from the locks
edited in picnik ...
Adjustable Threshold, text (with difference blending) and mirror frame
sunset on the city [cinematic version]
from Charlestown
(at Butterfly Creek, Auckland... we had a 5 hour stopover in Auckland and walked over to Butterfly Creek to kill some time.)
product shot
I've been doing product shots for my friend's gift shop for the last couple of years... and I think I've finally got the hang of it. This one came out really good, I thought, so I thought I would share it.
curiouskiwi is having a massage
pass with care
Painting the line.
[picnik: b&w effect using paintbrush to put the orange bits back in; posterize]
it has a song
A fantail in my garage this morning...
[orcon filter, text via picnik]
the gang
past present future
peppered fries
A "roast pork and apple wrap" ... my lunch choice at the Java House Cafe. Flickrmeet.
dawn at the lake
Jim lines up a shot
We had a Wellington Group Flickr meetup for lunch today... but we ran into Jim at the lake, waiting in vain for the Balloon event to begin.
Boy, the light is gorgeous here (if I may say so myself)... it really illustrates that golden light at sunrise.
dandy butterfly
a little butterfly feasting on our dandelions.
purple iris
It's Autumn and the iris is blooming.
"Eastr" Eggs!
[duotone editing of a b&w photo]
Hillary Clinton is my cousin??
I knew I was related to Celine Dion so when it was announced the other day that Hillary Clinton was related to her, I figured...
Yup, ninth cousins once removed. (the chart above is for my mother)
Won't change my vote though!
Ooh, just reading more, and found that Clinton is related to Jack Kerouac through the same line... so Jack Kerouac is my 8th cousin twice removed too! Now that's a lot cooler.
eggs in black and white
Easter eggs in the early morning
thistle hill
moo! [sepia cutout]
a very dry summer
[picnik: sepia effect using paintbrush to add back the original colour of the cow]
watch your step
colourful mural
Rachel & Sophie's class is painting this mural.
like a blanket
The cloud was descending like a blanket over the hills.
Bike Day at school
Thursday is bike day at the kids' school. Well, it's actually called "wheels day", hence the skateboard and scooters. :)
lenticular lineup
Two of the 4 lenticular clouds that were in a line in the sky.
not a space ship
I was driving down the road and saw this (and other ) lenticular cloud. When I got home, I rushed in, got the camera, and rushed out again to get the photo. Unfortunately, by then, the cloud had 'broken up' a bit, so it's not as distinct as it was a few minutes earlier.
hanging out at Grandma & Granddad's
Return to toddlerhood... preparing my post-surgical lunch.
I had 2 wisdom teeth removed on Tuesday, so my chewing ability is somewhat compromised for a few days.
Return to toddlerhood... preparing my post-surgical lunch.
I had 2 wisdom teeth removed on Tuesday, so my chewing ability is somewhat compromised for a few days.
Return to toddlerhood... preparing my post-surgical lunch.
I had 2 wisdom teeth removed on Tuesday, so my chewing ability is somewhat compromised for a few days.
the sun goes down
view from the trees
My in-laws' house through the trees
fuel for the fire
One of the fallen gum trees is almost ready for the stove.
stand of gums
Some of the gum trees at Gary's parents' place
straight up
a cabbage tree
shadows in the dry
dried up
there once was a pond
January 2008 was the driest January since 1926, with only about 15% of average monthly rainfall... February hasn't been any better. 2007 was very dry, with only about 60% of average annual rainfall... please! send us some rain!
Let the sun shine!
I am *so* ready for spring...
Now I know who's been 'stealing' my sunflower seeds!
behind bars
Took this photo through our family room window when I spotted the bird stealing sunflower seeds from my sunflowers!
My "art work" in support of Obama for President 2008.
I hope that everyone out there who has the opportunity to vote does so. It matters not to me whom you vote for... but just vote. Our world is too important to sit back and let someone else make the choice.
sunflower and bees
Three bees on the sunflower
just about at the time of maximum eclipse, with about 50% coverage.
(close up of a piece of paper showing a shadow made through a pinhole in another piece of page ... second attempt inside this time without the wind blowing my paper!)
My high school science teacher would be proud... this is the technique we used to view a partial eclipse in Texas way back in the late 70s. ;)
just about at the time of maximum eclipse, with about 50% coverage.
(piece of paper showing a shadow made through a pinhole in another piece of page)
See the tiny "sun"?
through the viewfinder
fun with the 'webcam' function of picnik
Boost colour, then reverse focal b&w, framed, and text.
getting up steam
for the "black and white flowers" project on utata
[holga-ish effect on picnik]
Sunflower on a Wall
Picnik Tutorial: www.flickr.com/groups/picnikers/discuss/72157627557475002/
gray skies are gonna clear up
it's been such a cold, windy, wet week that I needed something to brighten my day... found this in my archives from January 2008.
Protect the Earth
Earth Day 2010
cook strait
(from the archives)
Chalice Panography-ish
Chalice, a sculpture by Neil Dawson
Created using the new "panography-ish" feature effect on picnik
original image (shown in comment below) altered using new Pixel Bender effects now available in the Sandbox on Picnik.com
I first used the "ripple effect" on the background only (by using the effect paintbrush). Next used the HSL Filter to change the hue of the flower. Finally, a very faded Lomo-ish effect to give it a bit of pop.
a beauty [cutout]
In the rose garden in Pollard Park, Blenheim, NZ.
[selective desaturation done in Picnik]
purple through green
My Thursday Walk around the garden.
To support breast cancer research in New Zealand, pls TXT PINK to 336 to donate $3
October is Breast Cancer Awareness Month.
The New Zealand Breast Cancer Foundation has lots of information.
(I have no connection to the organisation other than being a supporter)
petunias in the wind
My Thursday Walk around the garden.
a sea of dandelions
My Thursday Walk around the garden.
My Thursday Walk around the garden.
Our gladioli are in bloom
7 foot
Our sunflowers continue to grow... no flowers yet.
like faces II
dreamy version
3 in a row
faded beauty
Trying out Picnik's new "Curves" feature with lots of built=in presets. This is the 'polaroid' curves setting, with a polaroid frame as well. :)
frilly pink
like faces
View from the Lookout
Fern in the bright sun
Circuit Track
ferns and more ferns
Fensham Reserve
Fensham Reserve
Our New Year's Day excursion.
Our new 2008 calendar from redbubble ... it looks great in our kitchen.
creative plumbing
The downpipe needed a bit of bending.


text:
Little Charley Bear Bedroom Playset
product code: 131736
see more in this range by Little Charley Bear
Playtime comes before bedtime for Charley who can't resist playing with his toys before he goes to sleep.
When he is ready for bed he puts all his toys away in his toy box then gets into bed with his very own blanket.
Set includes poseable Charley bear figure, bed, toys and toy box.
How does this help my child ?
This toy encourages your child to enjoy using their imagination.
This product is available for:
Standard Delivery
Normally delivered within 3-5 working days (exclusions apply including postcode restrictions and extended timescales). Exceptional delivery circumstances beyond our control such as bad weather or courier delays may cause your order to take longer to deliver.
FREE for orders over £40, otherwise £3.95
Express Delivery
Order before 4pm for delivery on the next working day to UK mainland addresses. Regrettably this service is unavailable for deliveries to Northern Ireland.
£4.95 on all orders
UK returns
ELC are happy to refund or exchange any unused merchandise returned within 30 days of purchase upon production of your receipt, as long as they are returned in an unused condition and in their original packaging. Please see Terms and Conditions for details. This does not affect your rights if the product is faulty or mis-described.

subset: commoncrawl


text:
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text:
I have been unable to find an answer for this. The last spec I seem to find that mentions backward compatibility is 2.1.
They are backward compatible. But - since each version brings new functionalities with it, only the basic function set is backward compatible all the way, see the table for more detail. In addition to that 2 devices wanting to communicate using bluetooth have to support the same profile(s), the full piece that i copy/pasted from here.
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protected by Community♦ Oct 8 '14 at 20:47
Thank you for your interest in this question.
Because it has attracted low-quality or spam answers that had to be removed, posting an answer now requires 10 reputation on this site (the association bonus does not count).
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Those of you with better knowledge in this realm, how is this vs a GF2/3? Been using my Nokia N8 on Vacations for a few travels now (which I have gotten some great shots),but I figure it's time to save the cell phone cam for spontaneous shots and buy a big boy camera for travels lol.
FWIW I seem to tend to lean towards night/low light photography (almost any cam today can get decent daytime shots I find).
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Jan 3rd, 2013 04:11 AM #16
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Jan 3rd, 2013 05:31 AM #17
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GF2/3 hass micro 4/3 sensor which is much larger than V1's 1" sensor, so it has superior low light IQ.
NEX's APS-C sensor, in turn, would be better than GF2/3.
Full frame is better still, but its price range is not comparable to these cameras.
Having said that, any of these would be a major step up from your N8 in low light photos.
But if you want the best low light photo, I would suggest NEX-5R or 6 and pair it with a fast prime lens (preferably image stabilized), and you'd be in heaven.
With the Hand Held Twilight mode, you can even take decent hand held low light shots without a tripod.
Jan 3rd, 2013 08:10 AM #18
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2.7 crop factor??Reply With Quote LOG IN TO THANK No one has yet thanked dslrnewb for this post.
Jan 3rd, 2013 08:47 AM #19
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Jan 3rd, 2013 10:02 AM #20
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Wow great price for a good mirror-less camera. I've been seeing the J1 with 10-30mm lens only on sale recently for $359 but this is a much better deal. Might pick one up for the GF...thanks OP!Reply With Quote LOG IN TO THANK No one has yet thanked Ironballz for this post.
Jan 3rd, 2013 10:46 AM #21
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How does this deal compare to the Sony 5R for $529 or Sony NEX-F3 for $399?Reply With Quote LOG IN TO THANK No one has yet thanked the_reds for this post.
Jan 3rd, 2013 10:54 AM #22
For stills the Sonys will take better pics but for anything moving the Nikon will destroy the Sonys.
They are both good cameras, I just think the V1 is an exceptional deal with the built in viewfinder (Costs $250+ extra for the Sony) and the included prime lens (again, add $200+ to the cost of the Sony.)
The Sonys are great cameras but there's no way you're getting a Sony with all this extra stuff at $400. Depending on what you feel the kit lens is worth, this works out to paying $100 or less for the V1 body.
Last edited by Kurtz7834; Jan 3rd, 2013 at 10:58 AM.
Jan 3rd, 2013 10:57 AM #23
As I mentioned earlier, everyone just assumes this has poor low light performance due to the smaller sensor, but it's not actually the case.
Of course, the NEX, E-PM2 will outperform this in low light. But as I mentioned earlier, I returned the E-PM2 due to its poor focus tracking. Great sensor but poor real world performance in low light shooting. Part of that is probably due to its crappy kit lens but the E-PM2 plus a decent prime lens will cost at least $850. The V1 has the fastest and best focus tracking of any camera this size.
Last edited by Kurtz7834; Jan 3rd, 2013 at 11:22 AM.
Jan 3rd, 2013 10:59 AM #24
Jan 3rd, 2013 11:03 AM #25
Most of the reviews trashing the V1 were considering the MSRP of $800 or $900. Everyone would agree that the V1 launched way overpriced.
No sane person would trash this V1 deal, for all you're getting at $400. With the prime and kit lens, you're ready to shoot most stuff. All you (maybe) need is a telephoto.
Last edited by Kurtz7834; Jan 3rd, 2013 at 11:14 AM.
Jan 3rd, 2013 11:08 AM #26
Jan 3rd, 2013 12:11 PM #27
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NEX-5R and 6 also has on sensor phase detection AF, and they help in AF tracking.
Smaller sensor would always be better in AF because the Depth of Field is larger and can tolerate more AF errors.
The biggest question - how long will they support the small sensor Nikon 1 system?
Nikon has started filing patents for a APS-C size sensor mirrorless camera system. With Canon going the large sensor route, Nikon has got to keep up.
So when Nikon is ready to release an APS-C mirrorless, what role would the Nikon 1 system play? How much support will it get?
No sane person would trash this V1 deal, for all you're getting at $400. With the prime and kit lens, you're ready to shoot most stuff. All you (maybe) need is a telephoto.
Jan 3rd, 2013 12:17 PM #28
If someone wants to move to another system down the road I'm sure they can sell the two lenses alone for a couple of hundred bucks at minimum, and get the use of a high performance 'compact' in the meantime. The body will be worth $50 to $100 for a couple of years. And that's assuming Nikon abandons this system, worst case scenario.
Everything camera related is depreciating rapidly these days. The prices of NEX and m43 bodies and lenses are going to fall significantly as competition heats up.
This is why I wouldn't suggest making a huge lens investment in any mirrorless system just yet. Wait to see what Canon does, etc.
Last edited by Kurtz7834; Jan 3rd, 2013 at 12:41 PM.
Jan 3rd, 2013 01:28 PM #29
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Jan 3rd, 2013 03:05 PM #30
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Nikon has already announced a wide angle zoom for Nikon One: 6.7-13mm (the equivalent of 18-35mm in full frame). And unlike most ultra-wide angle zooms, this will come with optical stabilization.


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Rag & Bone
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Crepe jersey slim pant with contrast side panels. Quarter top pockets at front and rear welt pockets. 8.5" rise. 36" inseam. 14" leg opening. Available in Black. Triacetate/rayon. Dry clean. Style # 501920262
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Archive for the 'Gallery Updates' Category
'Two Days, One Night' will premiere in competition at the Cannes Film Festival next month. Check out new stills, a poster and a trailer!
'Blood Ties' is out in theatres and VOD in the US. Check out various videos about the movie as well as new interviews with Marion. There are also new movie posters in the gallery.
WWD.com reports that Marion Cotillard's latest campaign with Dior features several new versions of the famous Lady Dior handbag, including one bearing a floral print, and Marion jumping with grace on a trampoline wearing looks from the pre-fall collection by Dior's couturier Raf Simons. The shots were captures by photographer Jean-Baptiste Mondino and will debut […]
The Weinstein Company will release 'The Immigrant' in NY/LA on May 16, 2014. Also enjoy over 100 new additions of stills from the movie.
'The Immigrant' will be released in France on DVD and Blu-ray next week. I received my Blu-ray a few days early so I added loads of HQ screencaptures of Marion Cotillard as Ewa Cybulski.


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Arrested Development (TV Series)
For British Eyes Only (2005)
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Rich Benjamin sharply observes modern society and politics.
His cultural and political analysis appear regularly in public debate, including on NPR, The New York Times, The New York Times Sunday Book Review, MSNBC, C-SPAN, and Salon.com. He is the author of Searching for Whitopia: An Improbable Journey to the Heart of White America, selected as an Editor's Choice by Booklist and The American Library Association (2009).
Born in New York City, Rich grew up in far-flung places (in the US and abroad). He devoured English and political science at Wesleyan University (BA) and Modern Thought and Literature at Stanford University (PhD).
Rich was recently a Fellow in the literary arts at the Bellagio Center (Italia), Rockefeller Foundation. There, he finished up a novel on money, risk, and heterosexual melancholy.
He is a Senior Fellow at Demos.


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|Publication number
|Publication type
|Application number
|Publication date
|Nov 22, 1988
|Filing date
|Jul 24, 1987
|Priority date
|Mar 24, 1986
|Fee status
|Publication number
|Can B. Hu, Donald D. Solomon
|Original Assignee
|Becton, Dickinson And Company
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (6), Referenced by (121), Classifications (30), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a division of application Ser. No. 843,323, filed 3/24/86, now U.S. Pat. No. 4,720,512.
This invention relates to an antithrombogenic-containing polymeric material and process for making the same. More particularly, the invention relates to a method for preparing antithrombogenic polymeric articles which employ covalently bonded hydrophobic groups bonded to the polymeric surface to provide increased antithrombgenic activity.
Extensive investigations have been undertaken over many years to find materials that will be biologically and chemically stable towards body fluids. This area of research has become increasingly important with the development of various objects and articles which can be in contact with blood, such as artificial organs, vascular grafts, probes, cannulas, catheters, hyperalimentation catheters and other long indwelling vascular catheters and the like.
Artificial materials are being increasingly used as blood contact devices and may be subject to potential generation of thrombus. When blood contacts foreign materials a complex series of events occur. These involve protein deposition, cellular adhesion and aggregation, and activation of blood coagulation schemes. Considerable research effort has been focused on this blood-material-interaction in the last twenty years with such devices. The overall objective of these investigations has been to minimize the potential for thrombus formation, such as the device when introduced into the body upon contact with blood.
Various methods have been devised for producing such a material, most of which involve chemically bonding a quaternary ammonium salt to the polymer and then heparinizing the same. Usually, this is done by incorporating an amine in the polymer, quaternizing the amine, and then heparinizing or bonding an antibiotic to the quarernized material.
In one method taught by R. I. Leininger and G. A. Grode, U.S. Pat. No. 3,457,098, a quaternary amine is incorporated into an epoxy resin. Subsequent exposure to sodium heparinate dissolved in water then results in ionically bound heparin. The polymer systems are essentially epoxy resins which are rigid polymers which are not suitable for forming medical devices such as catheters or other devices requiring extrusion. These polymers also are not appropriate where flexibility in the device ls required.
R. I. Leininger and R. D. Falb disclose in U.S. Pat. No. 3,617,344 another process for binding heparin. This system differs from the previous system in that low molecular weight chloromethyl groups are absorbed to the surface of a polymer substrate. Subsequent amination by a tertiary amine and quaternization resulted in a positively charged surface for binding with heparin. The concept, in general, embodies the use of low molecular weight quaternized groups to ionically bind heparin.
U.S. Pat. No. 3,846,353 to H. M. Grotta involves use of long chain alkyl quaternary amines on the surface of a polymer wherein the positively charged surface is exposed to a solution of sodium heparinate. The amines are dissolved in an organic solvent consisting of toluene, petroleum ether and mixtures thereof. One primary deficiency of the Grotta method is the use of toluene as a coating solvent. Toluene, when used with latex materials, results in a swelling of the products and destruction of essential elastic properties, rendering itself practically useless. In particular, this effect is seen with balloons present on balloon catheters wherein the balloon component becomes extremely fragile and is basically destroyed. Residues of toluene that may remain on the devices from processing which are targeted for internal use are thus harmful to the ultimate user. A second deficiency of ionically bonded systems is the short lifetime of the ionically bonded heparin due to desorption.
S. Yen and A. Rembaum prepared a neutral polyurethane elastomer which is subsequently quaternized and ionically bonded to heparin, U.S. Pat. No. 3,853,804. The main disadvantage of this system is that it is a chemical complex and toxic solvents are used to achieve solubility when coating. The coating technique, however, is difficult to perform due to the solvent (DMF) requirement. The patent of N. Harumiya et al., U.S. Pat. No. 3,844,989, describes a polymer composition of water-insoluble cationic copolymers having hydrophilic components, quaternary amine groups, and hydrophobic moieties. Heparin is bonded ionically to the quaternary ammonium groups via absorption after the polymer components are contacted with a heparin solution. This method involves use of complex synthesis procedures and is not readily applicable to coating other polymeric or non-polymeric materials.
U.S. Pat. No. 4,521,564 to Solomon et al. discloses antithrombogenic polyurethane polymers having the antithrombogenic material covalently bound to the polyurethane. The polyurethane polymer material is treated with a solution of a polymeric amine selected from the group consisting of a polyvinyl amine. a polyalkylenimine having 2 to 4 carbon atoms per amine unit and mixtures thereof so that the polymeric amine becomes covalently bonded to the polyurethane substrate. An antithrombogenic agent is then covalently bonded to the polymeric amine.
It would be desirable to provide a material which has excellent biological and chemical stability towards body fluids, namely blood, and which retains its antithrombogenic agent and antibiotic effect for a long term while being slowly leachable when in contact with blood. lt would also be desirable to provide materials which have enhanced antithrombogenic activity.
The present invention accomplishes all of these needs and improves on the prior art compositions and methods of enhancing the availability of the antithrombogenic agent to blood, thereby increasing the agent's activity. Consequently, enhanced hemocompatibility of the products of this invention is also achieved. More particularly, the present invention concerns articles having antithrombogenic properties comprising:
(a) a polymeric solid support structure
(b) a polymeric material rich in amine content which serves as a substrate for an antithrombogenic agent, said polymeric material being selected from the group consisting of primary amines having a carbon chain length of from 2 to 10,000, a polyalkylenimine having 2 to 4 carbon atoms per amine unit and mixtures thereof bonded to said polymeric support structure; and
(c) an antithrombogenic agent covalently bonded to said polymeric material rich in amine content: wherein the activity of the antithrombogenic agent is enhanced by the hydrophobic material or functional groups covalently bonded to the substrate surface.
Those polymeric materials rich in amine content which serve as a substrate. e.g., bonding site, for the antithrombogenic agent, are preferably amine rich polyurethane urea polymers (referred to herein as APU polymers). These polymers are prepared as solutions which are then used to coat the polymeric support structure. For example. if the support structure is a cathether, tubing or other device, it can be dipped, brushed, sprayed or otherwise coated with the amine rich material. The coating bonds to the support structure surface, providing a site on which antithrombogenic materials can subsequently be attached covalently. However, unlike the prior art, the instant invention further prepares the amine rich substrate surface prior to bonding the antithrombogenic agent to the amine substrate. This further treatment comprises the introduction of hydrophobic materials or groups onto the substrate surface.
Preferred polymeric material rich in amine content include polyether based urethaneureas such an poly(ethylene oxide) urethane-urea, poly(propylene oxide) urethaneurea, poly(tetramethylene oxide) urethaneurea; polyester based urethaneureas such as poly(ethylene adipate) urethaneurea, poly(propylene adipate) urethaneurea, poly(tetramethylene adipate) urethaneurea, poly(hexamethylene adipate) urethane urea; other types of polyurethane ureas such as polycaprolactone urethaneurea and polybutadiene urethaneurea. Mixtures of these are also useful.
While the present invention has been described in terms of using the preferred amine rich polyurethane urea polymers as the substrate on which to attach the anlithrombogenio agent, it should be recognized that other substrate materials having active amine groups or groups such as polyamides, polyimides, polyalkylenimines, and polyvinyl amines may be used.
The enhanced antithrombogenic activity of the articles is believed to be due to the greater hydrophobic character imparted to the substrate surface. This effect is achieved by covalently bonding to the substrate surface a moiety selected from the group consisting of a flourine compound, a siloxane compound, a silazane compound, a silane compound, and mixtures thereof. In the case of the fluorine-containing compouds, the fluorine group is believed to covalently bond to the substrate surface. In the case of the siloxane, silane and silazane compounds, the silicone group is believed to covalently bond to the substrate surface.
Useful flourine-containing compounds include Freon� compounds such as dichlorodifluoromethane, chlorotrifluoromethane, bromotrifluoromethane, tetrafluoromethane, chlorodifluoromethane, fluoroform, 1,1,2-trichlorotrifluoroethane, 1,2-dichlorotetrafluoroerhane, hexafluoroethane, tetrafluoroethylene, as well as hexafluoropropylene, boron trifluoride, silicon tetrafluoride., sulfur hexafluoride, sulfur tetrafluoride, tungsten hexafluoride, and fluorine among others. The preferred fluorinated compound is, however, hexafluoropropylene. Mixtures of these compounds are contemplated.
Those siloxane compounds useful have the formula: ##STR1## wherein R1, R2 and R3 are aliphatic or substituted aliphatic groups having an aliphatic carbon chain of 1-4 carbons; and n is an integer from 1 to 100, preferably from 3 to 20. Thus, aliphatic chains of up to 4 carbons having a benzene ring or other aromatic or aliphatic group substitution thereon are contemplated.
Those silazanes useful include compounds corresponding to the formula: ##STR2## wherein R1, R2, R3 and R4 can be alkyl C1 -4 or hydrogen.
Those silane compounds useful have the formula: ##STR3## wherein, R1, R2, R3 and R4 are selected from the group consisting of aliphatic groups, substituted aliphatic groups, aromatic groups, substituted aromatic groups, halogens, alkoxyl groups, vinyl groups and mixtures thereof.
The bonding of the fluorine, siloxane, silane and/or silazane moieties to the polymeric substrate surface is accomplished via glow discharge (ionized gas) treatment. This process is generally referred to in the art as plasma treatment. Plasma treatment is accomplished using a glow discharge ionization chamber, whereby samples are placed in the chamber and the chamber pressure is reduced to a minimal level. e.g., 0.1 torr or less, via a vacuum pump. The fluorine, siloxane, silane and/or silazane compounds are introduced in gaseous form into the plasma chamber to a desired level, e.g., about 0.3 torr, and purged to a level of about 0.1 torr to minimize potential contamination from other gases such as air. Purging is then repeated, and the final desired pressure of the gas is reached. For example, a pressure of about 0.1 to about 5 torrs is desired, and most preferably about 0.3 torrs. Radio frequency power is then generated and applied to the gas in the chamber for a fixed period of time. For example. about 10 to about 100 watts might be applied for a period of about 10 to about 20 minutes. The ionization reaction is allowed to proceed during this interval, at which time the power and vacuum are terminated and air or nitrogen gas is introduced to open the chamber.
It is necessary to maintain a balance of four factors during the plasma treatment of the substrate surface: power (wattage); exposure time (reaction time); gas flow rate; and chamber pressure. If too much wattage is applied for too long a period of time, the polymeric amine compound which serves as the site for bonding the antithrombogenic agent, could lose its functionality through cleavage or substitution by the gaseous moieties in the ionization chamber. Too little wattage and/or exposure produce insufficient bonding of the hydrophobic moieties to the substrate surface. Thus, the wattage (power applied), exposure time of the substrate surface to the gaseous chamber, flow rate of the gas, as well as the chamber pressure, must be controlled within specified ranges. Variation of one of these factors may cause adjustment of the other factors in order to produce the desired result. The wattage applied should be from about 1 to 700 watts, preferably less than about 200 watts and most preferably from about 5 to about 50 watts. The flow rate of the gas in the chamber should be about 1 to about 500 standard cubic centimeters per minute (cc/min), preferably about 1 to about 100 cc/min, and most preferably about 1 to about 50 cc/min. The chamber pressure, during the treatment of the substrate surface, should be maintained in the range of about 0.1 to about 100 torrs (mm of mercury), preferably about 0.2 to about 10 torrs and most preferably about 0.3 to about 5 torrs. Exposure time of the substrate surface to the chamber atmosphere under the above ranges vary widely from a few minutes or hours to about 24 hours. Preferably, at 50 watts, 0.3 torrs and 5 cc/min, a time of about 10 minutes to 1 hour is sufficient to impart excellent hydrophobic character to the substrate surface.
FIG. 1 shows a graphic illustration of the plasma treatment.
FIG. 2 is a graphic illustration of the process of producing the articles of the invention.
FIG. 3 shows a picture of the tubing treated with the control sample.
FIG. 4 shows the tubing treated with composition of the invention.
The plasma treatment covalently bonds radicals produced from the gas to the substrate surface. A graphic illustration is given in FIG. 1 using hexafluoropropylene as an example. As can be seen from the illustration, hexafluoropropylene dissociates into a number of different products.
The term antithrombogenic agent or material as used herein refers to any material which inhibits thrombus formation on its surface, such as by reducing platelet aggregation, dissolving fibrin, enhancing passivating protein deposition, or inhibiting one or more steps within the coagulation cascade and which forms an ionic complex with quaternary ammonium salts. Illustrative antithrombogenic materials may be selected from the group consisting of heparin, prostaglandins, sulfated polysaccharides, and mixtures thereof. Heparin is preferred. It should be understood that these materials are used in their natural form or as salts thereof, such as the sodium, or lithium salt. In addition to the foregoing antithrombogenic agents, optional supplemental amounts of antithrombogenic agents may also be used that are not reactive within the scope of the invention to further enhance the effects of the materials. Exemplary materials include urokinase, streptokinase, albumin and so forth.
The polymeric materials used in the invention as the solid support structure may be selected from a wide range of polymeric materials. The particular formulations do nor constitute a critical aspect of this invention other than to serve as a solid support structure for further treatment according to the inventive process.
Illustrative plastic materials useful as the support structure may be selected from the group consisting of polyethylene, polypropylene, polyurethanes, polyurethanesilicone copolymers, polyurethane-ureas, polycarbonates, silicone rubber, polyesters, nylons, natural rubber, polyvinyl chloride, acrylics, polystyrene, copolymers of polycarbonate and silicone rubber and mixtures thereof. The plastic materials are preferably preformed into the desired shape or structure for the particular application prior to treatment according to the invention.
The sequence of steps used to prepare the articles of this invention are essential to obtaining the desired antithrombogenic activity. The support structure should first be coated with the amine substrate. The coated support structure is then subjected to plasma treatment. Finally. the antithrombogenic agent is bonded to the amine substrate and the article is complete. If plasma treatment is performed as after the antithrombogenic agent is bonded to the amine substrate, it is likely that the ionization process may denature, inactivate or otherwise modify the antithrombogenic agent. Similarly, plasma treatment as a first step to coating with the amine substrate, would tend to increase adhesion of the coating to the support structure rather than increase the activity of the subsequently bonded antithrombogenic agent. Thus, it is essential to the inventive process and articles produced via this process that the steps be carried out in the sequence recited.
A preferred embodiment of the instant invention uses hexafluoropropylene as the gas for plasma treatment and uses a polyurethane solid support structure having an amine rich polyurethane urea coating bonded to heparin. FIG. 2 is a graphic illustration of the process of producing the articles of the invention, as well as depicting the prior art route of U.S. Pat. No. 4,521,564. The polymeric support structure (PSS) is shown as being coated with an amine rich polyurethane compound (APU). The prior art then bonded the antithrombogenic agent (heparin) to the APU. Heparin is shown as being closely held to the surface of the final product. The inventive process, however, is distinct in that prior to bonding of the heparin to the APU, the coated support structure is plasma treated to introduce hydrophobic character onto the substrate surface. FIG. 2 shows one of the probable chemical structures of the substrate surface subsequent to plasma treatment (PT-APU). The final product of the inventive process is intended to depict the physical extension of the heparin away from the surface of the substrate and the support structure due to repulsion by the hydrophobic character of the substrate surface, whereby the heparin is more available for contacting blood.
In the reaction equation scheme depicted, the polymeric solid support structure is contacted with an amine rich polyurethane urea substrate, which substrate provides a means for coupling with the antithrombogenic agent. The next step is plasma treatment with the desired gas (hexafluoropropylene) yielding hydrophobic groups on the surface of the substrate which "repel" the antithrombogenic group (heparin) next to be added. In the final step, aldehyde activated heparin is reacted with the substrate to form a structure wherein heparin is covalently coupled to the substrate. The resulting product demonstrates improved antithrombogenic efficacy as well as permanency and nonleachability.
Modification of the surface of the polymeric substrate using plasma treatment renders the substrate surface more hydrophobic. These hydrophobic groups minimize the interaction of the hydrophilic antithrombogenic group (e.g., heparin molecules) causing the latter to stay extended outwardly from the substrate surface, thereby making them more available for contacting bIood and consequently more active in preventing thrombus formation.
As previously mentioned, one particularly preferred plastic solid support material is polyurethane polymers, which may contain conventional polyisocyanates, low molecular weight glycols and high molecular weight glycols. The polyisocyanates useful in the invention in introducing the urethane linkage into the polymer chain may be selected from a wide range of aliphatic, cycloalipathic and aromatic polyisocyanates. Useable diisocyanates may contain noninterferring groups, e.g., aliphatic hydrocarbon radicals such as lower alkyl or other groups. having substantially nonreactive hydrogens as determined by the Zerewitinoff test J. Am. Chem. Soc. 49,3181 (1927). The diisocyanate often has at least 6 carbon atoms and usually does not have more than about 40 carbon atoms. Diisocyanates of about 8 to 20 atoms in the hydrocarbon group are preferred. Suitable diisocyanates include 2,4-toluene diisocyanate; 2,6-toluene diisocyanate; 1,4-cyclohexane diisocyanate; dicyclohexylmethane 4,4'-diisocyanate: xylene diisocyanate: 1-isocyanate-3-isocyanatomethyl-3,5,5-trimethylcyclohexane: hexamethylene diisocyanate: methylcyclohexyl diisocyanate; 2,4,4-trimethylhexyl-methylene diisocyanate, isocyanates such as m-phenylene diisocyanate; mixtures of 2,4- and 2,6 hexamethylene-1,5-diisocyanate; hexahydrotolylene diisocyanate (and isomers). naphtylene-1,5-diisocyanate: 1-methoxyphenyl 2,4-diisocyanate diphenylmethane 4,4'-diisocyanate. 4,4'-biphenylene diisocyanate; 3,3 -dimethoxy-4,4biphenyl diisocyanate; 3,3-dimethyl 4,4'-biphenyl diisocyanate; and 3,3'dimethyl diphenylmethane 4,4'diisocyanate and mixtures thereof. The aliphatic and alicyclic diisocyanates employed in the process of this invention and the products made therefrom generally exhibit good resistance to the degradative effects of ultraviolet light.
The polyisocyanate compound used to form the prepolymers may contain a portion of polyisocyanates having two or more isocyanate (NCO) groups per molecule providing the urethane polymer compositions are not unduly deleteriously affected. The preferred polyisocyanate is selected from the group consisting of 4,4'-diphenylmethane diisocyanate, toluene diisocyanate, isophorone diisocyanate and methylene bis (4-cyclohexyl) diisocyanate.
The low molecular weight glycols and/or diamines may also be used to prepare the polymer which materials may have from 2 to 10 carbon atoms. Exemplary of these glycols are ethylene glycol, diethylene glycol, triethylene glycols, 1,4-butanediol, neopentyl glycol, 1,6-hexanediol, 1,8-octanediol, 1,2- and 1,3-propylene glycol, 2,3-butylene glycol. cyclo- hexane dimethanol (1,4-bis hydroxymethyl cyclohexane), dipropylene glycol, dibutylene glycol and 2-ethyl-2-(hydroxymethyl)-1,3- propanediol. Exemplary diamines include ethylenediamine, propanediamines, butanediamine, pentanediamine, hexanediamine, heptanediamine, octanediamine, 0-xylenediamine. 1,4-diaminocyclohexane, p-phenylenediamine, 1-methyl-2,4,diaminobenzene. bis(p-aminocylohexyl) methane, among others.
The high molecular weight glycols useful in the present invention may be a polyether diol or polyester diol and range in number average molecular weight from about 400 to about 3,000 and preferably about 500 to about 2,000. Examples ot suitable polyhydric alcohols are polypropylene glycols, polyethylene glycols and polybutylene glycols. polyesters of lactones, for example, ε-caprolactone or hydroxy carboxylic acids, for example, ω-hydroxycaproic acid, may also be used. Illustrative polyesters may contain hydroxyl groups, for example, reaction products of polyhydric alcohols reacted with divalent carboxylic acids. It is also possible to use the corresponding polycarboxylic acid anhydrides or corresponding polycarboxylic acid esters of lower alcohols or mixtures thereof, for producing the polyesters. The polycarboxylic acids may be aliphatic, cycloaliphatic, aromatic and/or heterocyclic and may optionally be substituted, for example, by halogen atoms and/or unsaturated. Examples of polycarboxylic acids of this kind include succinic acid, adipic acid, suberic acid, azelaic acid, sebacic acid, phthalic acid, phthalic acid anhydride, tetrachlorophthalic acid anhydride, endomethylene tetrahydrophthalic acid anhydride, glutaric acid anhydride, maleic acid, maleic acid anhydride, fumaric acid, dimeric and trimeric fatty acids such as oleic acid, optionally in admixture with monomeric fatty acids, terephthalic acid dimethyl ester and terephthalic acid dimethyl ester and terephthalic acid bis-glycol ester.
The polyethers containing at least 2, generally 2 to 8, but preferably 2 to 3 hydroxyl groups used in accordance with the invention are also known per se and are obtained, for example, by polymerizing epoxides. such as ethylene oxide, propylene oxide, tetrahydrofuran, styrene oxide or epichlorohydrin on their own. for example, in the presence of BF3, or by adding these epoxides, optionally in admixture or in succession, to starter components containing reactive hydrogen atoms, such as water, alcohols, or amines, for example, ethylene glycol. 1,3- or 1,2-propylene glycol, 4,4'-dihydroxy diphenyl propane, aniline, ammonia, ethanolamine or ethylene diamine. The most preferred polyether diols are polybutylene glycols.
While the preferred polyurethane and/or polyurethane urea compositions of the invention are small amounts of crosslinking agents to the compositions when they are coated onto the support in order to render them thermosetting. Suitable crosslinking agents are discussed above and include the listed diisocyanate compounds.
It should be recognized that the products of this invention are useable in a wide variety of devices designed for contacting body fluids. Exemplary articles which can be in contact with body fluids such as blood, include artificial organs, vascular grafts, probes, cannulas, catheters, hemodialysis tubing, hyperalimentation catheters and other long indwelling vascular catheters, and the like. A particularly preferred application, of the products of the invention is in catheter type devices wherein the inventive compositions are coared on either or both interior and exterior surfaces of the catheter.
The invention will be further illustrated by the following non-limiting examples. All parts and percentages given throughout the specification are by weight unless otherwise indicated.
This example demonstrates the preparation of the amine compound. This compound is used to coat the support structure of the instant invention prior to plasma treatment. Trimethylolpropane (44.73 grams) and 337.59 grams of a low molecular weight polyether polyol (Terathane 650) were added together in a mixing vessel (1 equivalent of each) and heated to about 45� C. The materials were then mixed thoroughly and 524.00 grams (4 equivalents) of hydrogenated diphenylmethylene diisocyanate were added. Dibutyl tin dilaurate in the amount of 14 grams (0.015%) was added to the mixing solution. After 5 minutes of mixing. the reactants were transferred to a 90� C. oven for 60 minutes. The prepolymer was then purged with nitrogen and stored.
Fifteen grams of this prepolymer were added to 30 grams of toluene to make a 33% wt/wt solution. A separate diamine solution was prepared by adding 4.1 grams of 1,6-hexanediamine to 20 grams of isopropanol and 10 grams of toluene. The diamine solution was stirred vigorously with a magnetic stir bar under nitrogen. The prepolymer solution was then added dropwise to the diamine solution over a two hour period. The reaction was stirred for an additional two hours. Glacial acetic acid (2.3 grams) was then added dropwise to the reaction mixture. The resulting composition was an amine rich polyurethaneurea polymer, which was then dried with nitrogen gas and finally with a vacuum.
The amine rich polyurethane urea composition was then dissolved in methanol to a 20% wt/wt solution for deposition on the polymeric support structure.
This example demonstrates a method of preparing an aldehyde activated heparin which is to be covalently bonded to the amine substrate prepared in Example 1. (A) shows radioactive labelled heparin. (B) shows non-labelled heparin.
Seventy-five (75) mls of water were added to a beaker which contained 150 mls of 1% 3 H-heparin solution. Then 1.5 grams of sodium acetate was transferred to the beaker. The pH of this solution was adjusted to 4.5 with glacial acetic acid. Sodium periodate (NaIO4) in the amount of 0.075 grams of was added and the solution was reacted for 20 minutes in a light protected reaction vessel with constant stirring. At the end of the reaction. 2.26 grams of glycerin was added to neutralize any remaining periodate. The solution was dried down overnight under nitrogen. Then the solution was reconstituted to 2% and the pH of the solution was adjusted to 6.6 by the dropwise addition of lON NaOH. The aldehyde activated 3 H-heparin solution was ready for bonding to the amine compound. It should be noted that other types of radioactive labelled heparin other than 3 H are useful.
7.5 grams of heparin was dissolved in 1125 mls of distilled water. Three (3.0) grams of sodium acetate was weighted and transferred to the heparin solution. The pH of this solution was then adjusted to 4.5 with glacial acetic acid. Sodium periodate (NaIO4) was added in the amount of 0.375 grams and the solution was reacted for 20 minutes in a light protected reaction vessel with constant stirring. At the end of the reaction, 11.30 grams of glycerin was added to neutralize any remaining periodate. Then the solution was reconstituted to 2%. The pH of the solution was adjusted to 6.6 by the dropwise addition of 10N NaOH. The aldehyde activated heparin solution was ready for bonding to the amine compound.
This example illustrates the preparation of an article having increased antithrombogenic activity utilizing the concepts of the present invention. The amine rich polyurethane urea (APU) substrate of Example was dissolved in methanol to a 20% wt/wt solution. A polyurethane support structure was coated with the APU. After coating, the substrate was placed in the nitrogen atmosphere at ambient temperature for 60 minutes. The coated tubing was then treated with hexafluoropropylene plasma (0.3 torr and 50 watts) for 15 minutes. using the plasma treatment unit manufactured by Branson/IpC (Model p-2075).
The samples were then placed in a reaction vessel which contained 0.025 g (2.5% weight heparin) sodium cyanoborohydride and 2% aldehyde activated 3 M-heparin, prepared via Example 2. The reaction was performed in a pH 6.6 aqueous solution at 50� C. Two hours later, the samples were removed and placed in a 3M saline solution for one hour to remove any loosely bonded or adsorbed heparin. Then these samples were re-reacted for a second two hour period at the same conditions as described above. Initial radiolabel assays showed that 87.8�12.9 micrograms of heparin was bonded per cm2 of surface area as compared to the control samples (143.4�3.3 micrograms per cm2) which were identically treated in all respects except without plasma treatment. After a dynamic leach scudy in 3M saline solution for 24 hours, the radiolabelled assay still showed 79.4�6.3 micrograms of heparin bonded per cm2 of surface area. In comparison, the controls showed 103.7�13.1 micrograms of heparin bonded per cm2 of surface area. This demonstrates the permanency of the covalently bonded heparin of this invention.
This example demonstrates the increased antithrombogenic activlty of the present invention compared to control samples prepared identically in all respects except without plasma treatment.
Two sets of polyurethane tubings were coated with the amine rich polyurethaneurea compound having heparin bonded thereon as described in Example 3. One set of samples was exposed to hexafluoropropylene plasma treatment and the other set of samples used as the control did not receive the plasma treatment.
Those samples to be plasma treated were then placed in a reaction vessel which contained 0.25 g (2.5% of heparin weight) sodium cyanoborohydride and 2% aldehyde activated heparin. The plasma reaction was conducted as described in Example 3.
An in vivo study was performed in such a way that one plasma treated sample was inserted into one external jugular vein of a dog, while the control sample was inserted in the other jugular vein of the same animal. The activity of bonded heparin was demonstrated by the loss of platelet adhesion (platelet uptake slope) and low thrombus weight. The average slope and thrombus weight of three dogs are listed as follows:
______________________________________ Plasma Treated Samples Control Samples______________________________________Slope 0.0188 � 0.0025 0.0413 + 0.0266Thrombus weight 4.53 mg � 1.89 mg 14.13 mg � 3.09 mg______________________________________
It is clear that the activity of the bonded heparin was enhanced through plasma treatment as indicated by the lower slope value and the lower thrombus weight. The photographs in FIGS. 3 and 4 clearly show the enhanced antithrombogenic activity of the instant invention. FIG. 3 shows a picture of the tubing treated with rhe control sample and FIG. 4 shows the tubing treated with the inventive composition. Both pictures were taken after leaving the tubes in the animal for 40 minutes.
This example demonstrates the use of a polyethyleneimine compound as the amine substrate. Thermoplastic polyurethane tubing (support structure) was placed in a borate buffer solution (pH 9) containing 0.5% glutaraldehyde and 0.1% polyethyleneimine (PEI) at room temperature for 30 minutes to allow deposition and bonding of the amine compound to the tubing. After rinsing with water the tubing was incubated in an aqueous solution of dextran sulfate (1 mg/ml, 0.15M Nacl, 50� C., pH 3) for 5 minutes and was then rinsed with water. Then the tubing was incubated in a 1% PEI solution at pH 9 for 5 minutes and was carefully rinsed with water. After drying the tubing in the nitrogen atmosphere at ambient temperature for 60 minutes. the tubing was treated with hexafluoropropylene plasma (0.3 torr and 50 watts) for 15 minutes, using the plasma treatment unit manufactured by Branson/IpC (Model p-2075).
The sample was then placed in a reaction vessel which contained 0.25 g (2.5% of heparin weight) sodium cyanoborohydride and 2% aldehyde activated heparin. The reaction was conducted as described in Example 3, producing a product with excellent antithrombogenic properties.
The invention being thus described, it will be obvious that the same may be varied in many ways. Such variations are not to be regarded as a departure from the spirit or scope of the invention and all such modifications are intended to be included within the scope of the claims.
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|U.S. Classification
|428/412, 428/424.8, 523/112, 428/421, 428/474.4, 428/447, 428/422, 428/425.5, 428/473.5, 514/822, 428/423.5, 428/423.7
|International Classification
|Cooperative Classification
|European Classification
|May 18, 1992
|Fee payment
Year of fee payment: 4
|Jul 2, 1996
|Maintenance fee reminder mailed
|Nov 24, 1996
|Lapse for failure to pay maintenance fees
|Feb 4, 1997
|Expired due to failure to pay maintenance fee
Effective date: 19961127


text:
MIAMI (AP) - The vice president of the northwest African country
of Sierra Leone is visiting South Florida.
Samuel Sam-Sumana was promoting increased trade and cultural
relations between his country of 6.2 million people and the state.
Sierra Leone had been racked with civil war in recent years, but
Sam-Sumana said fighting is over and the country is open for
He expressed interest in opening a consulate in Miami-Dade
County and establishing sister city relations.


text:
20 Jan 2012 9:49 PM #1
PR3 TabPanel - no method 'getAnimation'
Hi everyone,
I've got a mobile app that uses 1.1 and works great. Now, I'm wanting to try out 2.0 PR3 but I'm having trouble with the getting started tutorial.
I keep getting the following error:
Uncaught TypeError: Object [object Object] has no method 'getAnimation'
Now, I've read this similar post, and the "fix" stops the error from being thrown, but nothing appears on the screen.
My code is below. Any pointers as to what I am doing wrong?
Note: the alert() and console.log() statements execute perfectly and with the "fix" there are no errors, it's just that nothing appears on the screen.
new Ext.Application({ name: 'Sencha', launch: function() { alert('test'); console.log('launch called...'); Ext.create("Ext.Panel", { fullscreen: true, layout: 'fit', cls: 'touchodo-app-container', items: [ { title: 'Home', iconCls: 'home', html: 'Welcome' } ] }); } });
23 Jan 2012 7:52 AM #2
- Join Date
- Mar 2007
- Location
- Gainesville, FL
- Posts
- 39,144
- Vote Rating
- 1240
In PR3 this will work but this may change in PR4:
Ext.application({ name: 'Sencha', launch: function() { Ext.create("Ext.Panel", { fullscreen: true, layout: 'fit', cls: 'touchodo-app-container', items: [ { title: 'Home', iconCls: 'home', html: 'Welcome' } ] }); } });Mitchell Simoens @LikelyMitch
Sencha Inc, Senior Software Engineer
Check out my GitHub, lots of nice things for Ext JS 4 and Sencha Touch 2
Think my support is good? Get more personalized support via a support subscription. https://www.sencha.com/store/
Need more help with your app? Hire Sencha Services firstname.lastname@example.com
Want to learn Sencha Touch 2? Check out Sencha Touch in Action that is in print!
When posting code, please use BBCode's CODE tags.


text:
Turkey of the Year Awards
Originally Published: November 24, 2010By David Fleming | Page 2
I knew if I did this Turkeys of the Year column long enough, T.O. and I would eventually agree on something. Well, after 14 years it finally happened.
Last week, after the Bengals' epic, gutless collapse against the once 0-8 Bills -- they blew a 21-point lead and were outscored 35-0 in the second half -- Terrell Owens called his 2-8 team "terrible."
Took the words right outta my mouth. Now, I ask you, how bad do things have to be for T.O. to become the voice ...
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NEW ORLEANS -- The number of store units offering card-based frequent-shopper programs increased sharply from the second quarter of 1996 to the first quarter of 1997, moving from 4,235 to 5,867 -- a 38.5% increase in a nine-month period. These figures, based on surveys conducted by Retail Systems Consulting, Naples, Fla., indicate retailers' increasing use of frequent-shopper programs to reward loyal customers and gather information on shopping patterns. Survey results were presented at the ...
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Search Type: Posts; User: trbs
Search: Search took 0.03 seconds.
8 Jun 2011 11:28 AM
Yes I am...
Meaning I keep it running :)
But not actively develop for it.
14 Nov 2008 9:05 AM
Updated code to use Django 1.0
Now you can install Python + Django + Pygments and everything should work as expected.
13 Nov 2008 11:46 PM
The code for http://www.extpaste.com is now online in a Mercurial repository at http://hg.trbs.net/extpaste/
Please make sure to read the README and TODO file.
28 Oct 2008 11:45 PM
Sounds like some good idea's, together with the "run this code in a new window" future... However regretfully my time is very limited at the moment... Which is painfully obvious from the lack of...
7 Aug 2008 12:06 AM
Jump to post Thread: [0.9] Python Ext Builder by trbs
- Replies
- 7
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- 19,675
Thanks aconran !
Updated the code to check for the buildin Python2.5 version.
29 Jul 2008 5:11 AM
I remember having a reason for this when i first wrote it... but that has been so long ago that i cannot remember what it was :)
Regretfully i am (and have been) very busy with other projects,...
29 Jul 2008 5:05 AM
yeah pagingmemoryproxy is the same code for both ext1 and ext2
4 Jun 2008 12:48 PM
Cool thanks elDub...
Then at least i know that when i have some time, this will need to be addressed.
4 Jun 2008 12:24 PM
elDub; i also have not been able to try things out with Extjs 2.1 but from what i've seen so far ext.data and friends have not been changed much. So i expect things to work on 2.1. (again i have not...
11 Feb 2008 11:19 AM
That message declared in BasicForm.js as waitTitle.
It can be put in the translation as: Ext.form.BasicForm.waitTitle = "Please Wait..."
or as: Ext.form.Action.Submit.waitTitle = "Please Wait..."
1 Feb 2008 2:44 PM
Translation updates:
Updated Serbian
Updated Portuguese
Updated Norwegian, removed old ext-lang-no.js in favor of ext-lang-no_NN.js and ext-lang-no_NB.js
Updated German
Updated Turkisch
24 Jan 2008 5:43 AM
thanks guys :)
i never intended this to be used with large datasets, but it's clear you guys have a real need for it.
reading from the posts here i suggest the following:
- decouple sorting...
6 Jan 2008 12:34 PM
Jump to post Thread: Large applications with extjs by trbs
- Replies
- 16
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- 11,023
There are several solutions for loading forms from the server side. If you're going to use Python (Big fan of Python and quite a lot of reasonably large scale Python webapp here as well!!)...
29 Dec 2007 7:16 AM
i converted ext-lang-pt.js from ISO-8859 to UTF-8 and uploaded to svn :)
27 Dec 2007 3:17 PM
Yeah it should work fine in Ext2.0, it's used in one of the locale examples.
If there any bugs with it and 2.0 please post here and...
24 Dec 2007 4:50 AM
Committed fr, it and th languages. Thanks guys !!
killernay your file was not in UTF-8 and not valid Javascript (missing quotes).
Translators in general, please check and validate your files...
21 Dec 2007 8:42 AM
Jump to post Thread: Ext Holiday Schedule by trbs
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- 2
- Views
- 2,040
Thanks Jack, Brian, ReyBango, everyone I'm forgetting, and the rest of the community for all your hard work during this year making Ext the great framework it is!
Let's go and make 2008 known as...
21 Dec 2007 8:37 AM
Jump to post Thread: example using PHP tcp/ip connection? by trbs
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- 3
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- 2,934
Checkout the documentation on the php site with regards to sockets: http://nl2.php.net/sockets
Though if your on shared hosting i hope your provider has blocked these functions, cause normal php...
21 Dec 2007 8:29 AM
Jump to post Thread: Change language errors-messages by trbs
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- 3
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- 1,631
That's all! (you should need)
If the date is not localed properly, it's likely that the problem is one of the following things:
DateFormat is set incorrectly in ext-lang-sp.js
21 Dec 2007 8:23 AM
Okey, hope you figure it out before then.
It's too bad that i do not have the time to start writing up a working example from the code you posted... With my own projects / X-Mass and New Years...
18 Dec 2007 3:13 PM
Please do post a working demo of your problem online, that will help us help you tracking down this problem a _lot_ faster.
I have never played with DDView myself, but i would love to see in...
14 Dec 2007 12:12 PM
Committed to SVN, thanks !
14 Dec 2007 6:19 AM
[My Opinion]
Yes i know :) that's why i included the fix from the developers.mozilla.org site.
14 Dec 2007 5:44 AM
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- 2
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- 1,177
I've talked about something like this before with some people.
Called it a PrefetchingProxy, where you prefetch the surounding pages in a grid.
This way when a user presses forward or backwards...
14 Dec 2007 5:00 AM
Thanks a lot ! committed to svn
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The Piedmont Highlanders girls lacrosse team won Tuesday's home conference game against Clayton Valley Charter by a score of 12-6.
(March 30, 2010: Piedmont, CA 94611) In Tuesday's league battle, the host Piedmont Highlanders lacrosse team scored a close 12-6 win over the Clayton Valley Eagles.
The Highlanders now have a 2-3 record. They take the field next when they host Oak Ridge for a non-league battle on Friday, April 9. Piedmont will encounter a Trojans squad coming off a 8-6 league loss to Granite Bay (Granite Bay, CA). The Trojans record now stands at 3-8.
The Eagles (4-7) will now prepare for their match against Northgate (Walnut Creek, CA). The Broncos go into the Bay Shore match with a 2-1 record. In their last match, Northgate nudged Piedmont (Piedmont, CA), 11-10, in a league match.


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Grand Worthy Advisor
Hey friends! My name is Jessica and I am excited about being the Grandworthy Advisor for the ensuing year.
Just alittle bit about myself, I like to read, write, draw and watch TV. I like to listen to music, spend time on Tumblr and watch YouTube videos. I also like many outdoor activities such as hiking, biking, climbing and kayaking.
This fall, I will be attending community college studying to be a nurse. I also am working as a Certified Home Health Aide. I am very passionate about mental health awareness, since many people are touched by mental health issues themseleves or through family and friends.
I am very excited about working with all my Grand Officers this year!
In Rainbow Love and Service!


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Focuses on the theories behind web fonts: showing what makes a good font, why different fonts look the way they do, and how they affect the look of your web page.
All Courses
- Bare Bones (1)
- TextWrangler (1)
- Typography (2)
- Web (2)
- Web Design
- Web Fonts (2)
- Design (1)
- Web Foundations (1)
Skill level
- Beginner (2)
- Intermediate (2)
- Advanced (2)
- Appropriate for all (2)
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Choose fonts for a web site and create beautiful, readable type, incorporating web fonts, CSS styles, and simple typographic rules.
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