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Eva Helmerhorst
Associate Professor, Department of Molecular & Cell Biology
- Office
700 Albany Street
Boston, MA 02118 USA
- email@example.com
- Phone617-414-1119
- Education
MS, Vrije Universiteit, Amsterdam (The Netherlands)
PhD, Academic Centre for Dentistry (ACTA), Amsterdam (The Netherlands)
Research Interests
Research by Helmerhorst and coworkers is focusing on the role of the microbiome of the upper gastro-intestinal tract, the oral cavity, in the digestion of dietary gluten. Dietary gluten comprise a family of proteins that are abundantly present in the Western diet. Gluten proteins are fairly difficult to digest because of their unusual amino acid content and -sequence. In genetically predisposed individuals, gluten proteins elicit an auto-immune response leading to the destruction of the villi of the small intestine thus interfering with efficient uptake of nutrients causing celiac disease. The predominant amino acids in the gluten sequences are proline (Pro) and glutamine (Gln). Our recent investigations indicate that human saliva contains unique enzymes that can cleave the peptide bond C-terminal to the Xaa-Pro-Gln sequence. This tripeptide is prevalent in T-cell stimulatory gluten domains. While the human digestive enzyme system apparently lacks the capacity to neutralize essential immunogenic gluten domains implicated in celiac disease, such activities are naturally present in the oral microbial proteasome. These novel findings offer clinical insights as well as therapeutic perspectives for the treatment of celiac disease.
Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS One. 2010. In press.
Helmerhorst EJ, Traboulsi G, Salih E, Oppenheim FG. Mass spectrometric identification of key proteolytic cleavage sites in statherin affecting mineral homeostasis and bacterial binding domains. J Proteome Res. 2010. 9:5413-21.
Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Activity-based mass spectrometric characterization of proteases and inhibitors in human saliva. Proteomics Clin Appl. 2009. 3:810-820.
Sun X, Salih E, Oppenheim FG, Helmerhorst EJ. Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties. FASEB J. 2009. 23:2691-701.
Helmerhorst EJ, Sun X, Salih E, Oppenheim FG. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. J Biol Chem. 2008. 283:19957-66.
Helmerhorst EJ, Oppenheim FG. Saliva: a dynamic proteome. J Dent Res. 2007. 86: 680-693. Oppenheim FG, Salih E, Siqueira WL, Zhang W, Helmerhorst EJ. The salivary proteome and its genetic polymorphisms. Annals NY Acad Sci. 2007. 1098: 22-50.
Helmerhorst EJ, Alagl AS, Siqueira WL, Oppenheim FG. Oral fluid proteolytic effects on histatin 5 structure and function. Arch Oral Biol. 2006. 51:1061-1070.
Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, Socransky SS and Oppenheim FG. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol 2004. 97:1311-18.
Helmerhorst EJ, Murphy MP, Troxler RF and Oppenheim FG. Characterization of the mitochondrial respiratory pathways in Candida albicans. Biochim Biophys Acta 2002. 1556:73-80.
Helmerhorst EJ, Troxler RF and Oppenheim FG. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc Nat Acad Sci USA 2001. 98:14637-42.
Helmerhorst EJ, Van 't Hof W, Breeuwer P, Veerman EI, Abee T, Troxler RF, Nieuw Amerongen AV and Oppenheim FG. Characterization of histatin 5 with respect to amphipathicity, hydrophobicity and effects on cell and mitochondrial membrane integrity excludes a candidacidal mechanism of pore formation. J Biol Chem 2001. 276:5643-5649.
Helmerhorst EJ, Breeuwer P, Van 't Hof W, Walgreen-Weterings E, Oomen LCJM, Veerman ECI, Nieuw Amerongen AV and Abee T. The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. J Biol Chem 1999. 274:7286-91.
Helmerhorst EJ, Reijnders IM, Van 't Hof W, Simoons-Smit AM, Veerman EI and Nieuw Amerongen AV. Amphotericin B and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides. Antimicrob Agents Chemother 1999. 43:702-704.
Helmerhorst EJ, Hodgson R, Van 't Hof W, Veerman EI, Allison C and Nieuw Amerongen AV. The effect of histatin-derived antimicrobial peptides on oral bio¬films. J Dent Res 1999. 78:1245-50.
Helmerhorst EJ, van 't Hof W, Simoons-Smit AM, Veerman EI and Nieuw Amerongen AV. Synthetic histatin analogs with broad spectrum antimicrobial activity. Biochem J 1997. 326:39-45.
Grant Support
NIH/NIAID Grant AI087803 (R01): "Gastro-Intestinal Microbes Degrading Dietary Gluten". Role: Principal Investigator.
NIH/NIDCR Grant DE18132 (R21): "Oral Fluid Proteolytic Effects on Salivary Protein Structure and Function". Role: Principal Investigator.
NIH/NIDCR Grant DE07652 (R01): "Microbicidal Salivary Histidine-rich Proteins". Role: Co-Investigator.
NIH/NIDCR Grant DE05672 (R01): "Salivary Proteins in Dental Integuments". Role: Co-Investigator.
- Departments
- Molecular & Cell Biology
- Affiliations
- Faculty


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We are committed to providing continual education and growth opportunities to our staff in order to tailor to your needs. They attend seminars and workshops asMore
$1 mil. - $5 mil.in Revenue
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Church Banners for every occasions. Our church banners are available in either Fabric & Vinyl. We provide also Free to Customize.
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» About our Fabric/Vinyl Material
Concordia Supply Church Banners are printed on two kinds of material, Fabric or Vinyl. Our Fabric is a polyester "canvas like" material, for indoor use, and typically finished with hemmed pole loops on top and bottom. The fabric is NOT like a tshirt or felt. It is more similar to a canvas or pull down window shade. We choose this material because it is non-glare, has great color reproduction and hangs elegantly on our banners stands and walls.
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Concordia Supply's mission is to equip churches and ministry leaders with quality christian resources that transform lives for Christ.
Serving you and your ministry since 1949.
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- Root for Brazil
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Get behind your favorite squad and cheer for Brasil with this Brasil Supporter ball from Nike.
COVER: 32 panels of machine stitched PU for a durable ball. BLADDER: Reinforced rubber bladder provides enhanced shape retention.
BLADDER: Reinforced rubber bladder provides enhanced shape retention.
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Note: All of our balls are shipped deflated. This helps in keeping our shipping costs low, savings that we can pass on to you.
Apoya a Brasil con este balón Prestige de Nike. CUBIERTA: 32 paneles de PU cosido a máquina para hacerlo más duradero. VEJIGA: Hule reforzado para retener mejor su forma.


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Denon AH-C551K In-Ear Headphone
" I looked around for a review on these and didnt find many, so bought a pair and heres what i found out. - Nice build quality - Good comfortable fit - Worst cable design I have ever seen (wtf were they thinking?!) - Easy to be driven - Extremely well defined mids & highs (these are not laid back and softsounding!) - Good soundstage..." --fabiosouzajr
Comply T-400 Series Foam Tips (Black, 3 Pairs, Small)
"Small Talk Review: Ok, so under heavy construction, office work, daily use, and all the things people do, Rubber Buds have failed tons of other people. So Comply offers us their Foam Tips, with competition from others that aren't even as competitive in fair reasoning. Sound Tampering I found something unsuitable to a bunch of listeners, and myself included! With earphones,..." --whitemass
Denon AH-C300 Urban RaverTM In-Ear Headphones, Black
"full and detailed review here: http://www.head-fi.org/t/714564/denon-ah-c300-iem-review " --xkonfuzed
DENON AH-C560 Black | In-Ear Stereo Headphones (Japan Import)
"I bought these last summer during a visit to Taiwan. I had hoped to buy a replacement Audio-Technica CKM500 (which broke) but they have been replaced with the CKR5 which are a bit of a let-down with its bloated bass and congested soundstage. After trying out various headphones, the salesperson suggested the AH-C560, a mid-range Denon IEM released in 2010. Although they have been considered..." --FYLegend
Denon AH-C360 Advanced In-Ear Headphones
" I've tried out several pairs of in-ear phones and never got used to the feel of them. These are much more inviting straight away, as several earpads of different sizes are included. I found my size and was off to the races. The cable is a bit short, and I usually have to bring the included extension cable along with me on my commute. This is not a problem, just an..." --phallumontis
Denon AH-C400
Denon's new $249 AH-C300 may be the biggest, bassiest in-ear monitor in headphone history. Each of the IEM's seemingly bulky earpieces has one of Denon's patented Double Air Compression Drivers. It's an arrangement with dual 11mm drivers, both firing at each other into a chamber that vents directly to your ear. A miniature control wheel gives the same functionality as on...
Comply TX-200 Series Foam Tips (Black, 3 Pairs, S/M/L)
All the benefits of the T Series of Comply Foam Tips--increased stability, superior noise isolation, and comfortable memory foam--plus a special integrated Wax Guard technology that prevents wax from entering the sound port, helping to extend the life of your headphones. Fits select earphones from Blue Ant, Grado, Jays, Ultimate Ears and more. See compatibility chart for details.
Denon AH-C560R Premium Mobile Elite In-Ear Headphones with 3-Button Remote and Microphone (Black)
"OK so this headphone has been a trial for me. I bought with high hopes as I was looking for a AH-D7000 equivalent in in an IEM and in this case a $90 IEM, not a small order! So the question is did it achieve my goal and is it a worthy $90 contender? To answer my first question I can say it's not my D7000 but it does a VERY good job of coming close and is worth trying for anyone looking..." --dweaver
Denon Music Maniac In-Ear Headphones (AH-C250)
When was the last time you really sat and listened to your favorite piece of music? With Denon's line of Music Maniac headphones you'll want to do it again, and again, and again. Some people are just as obsessed about sound quality as we are. And they know sound quality is much more than the size of the driver and the cavity space in the ear cup - it's further enhanced by the...
Comply T-500 Foam Tips - 3 Pair Pack
Comply Foam Tips are a premium earphone upgrade that comfortably seal the ear canal to provide high levels of noise isolation and retention. They are made from unique breathable memory foam that is activated by body heat and becomes ultra soft, reducing irritation and fatigue. Once inside the ear, this foam will expand to create a seal, funneling pure sound into the ear canal, enhancing the...


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Quick Fix: Burgers With a Hint of Autumn
Published: Wednesday, November 14, 2012 at 8:27 p.m.
Last Modified: Wednesday, November 14, 2012 at 8:27 p.m.
Mushrooms, onion and a hint of maple syrup add an autumn flavor to these mini-burgers. Using a microwave shortens the timing for this dinner and saves washing extra pots.
Look for extra lean ground sirloin in the market. Ground turkey or chicken can be used instead. This meal contains 647 calories with 23 percent of calories from fat.
Use 2 regular burger rolls if sliders aren't available.
Prepare ingredients.
Start hamburgers.
While hamburgers sauté, make potatoes and red pepper.
To buy: 1 package button mushrooms, 1 jar Dijon mustard, 1 bottle maple syrup, ¾ pound lean ground sirloin (95 percent lean), 1 package whole wheat mini hamburger rolls, ½ pound sweet potatoes, 1 medium red bell pepper.
Staples: Onion, olive oil, salt, black peppercorns.
Makes 2 servings
• ½ cup coarsely chopped onion
• ½ cup coarsely chopped button mushrooms
• Salt and freshly ground pepper
• 2 tablespoons Dijon mustard
• 2 tablespoons maple syrup
• ¾ pound lean ground sirloin (95 percent lean)
• 4 whole wheat slider buns (mini hamburger rolls)
Place onion and mushrooms in a microwave-safe bowl and microwave on high 3 minutes. Add salt and pepper to taste.
For stove-top, heat a small nonstick skillet over medium-high heat and spray with olive oil. Add onions and mushrooms and sauté 3 to 4 minutes.
Mix the mustard and maple syrup together and set aside.
In a bowl, add half the mushrooms and onions and half the mustard mixture to the meat. Blend well. Add salt and pepper to taste. Form into 4 small hamburgers (about 3 inches in diameter.) Heat a nonstick skillet over medium-high heat and add the hamburgers. Sauté 2 minutes; turn and sauté 3 minutes. A meat thermometer should read 145 degrees for medium rare.
Place the burgers on the bottom of the 4 slider rolls. Spoon the remaining mushrooms and onions over the burgers and pour the remaining mustard mixture on top. Close the burgers with the tops of the slider rolls and serve 2 sliders per person.
Per serving: 495 calories (21 percent from fat), 11.7 g fat (4.4 g saturated, 5.2 g monounsaturated), 216 mg cholesterol, 47.6 g protein, 48.6 g carbohydrates, 6.3 g fiber, 632 mg sodium.
Makes 2 servings
• ½ pound sweet potatoes, peeled and cut into 1-inch pieces (1¾ cups)
• 1 medium red bell pepper, seeded and cut into 1-inch pieces (about 1 cup)
• 2 teaspoons olive oil
• Salt and freshly ground pepper
Place potatoes and red bell pepper in a microwave-safe bowl. Cover with plastic wrap or a plate. Microwave on high 5 minutes. Let stand 1 minute. Remove cover and add olive oil and salt and pepper to taste. Toss well.
Per serving: 152 calories (28 percent from fat), 4.7 g fat (0.7 saturated, 3.3 g monounsaturated), no cholesterol, 2.4 g protein, 26.2 g carbohydrates, 4.7 g fiber, 64 mg sodium.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Display Resolution Manager$14.95
Quick Specs
Total Downloads:13,653
Date Added:Jan. 10, 2006
Price:Free to try (7-day trial); $14.95 to buy
File Size:634.72KB
Downloads Last Week:20
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From ByteGems.com Software: Dispute display resolution and brightness settings with your colleagues or kids. Stop the squabbles with this program. This is a utility that allows multiple users sharing a computer to set their own display resolution, brightness and contrast options. It will switch monitor to the preferred resolution when the user starts working. System admin can set the default display resolution for all users and for when no one is logged on the system.
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I have created a dev environment of my website... using VirtualBox... and now I need to make it accessible outside of my home office network. I am using Virtualbox 4.1.18 installed on a Win7 desktop host. The virtual machine is running CentOS 5.6. My home office has a static ip. I am using a Linksys router e4200. The virtual machine is setup to use a bridged adapter. My virtual machine can access the web. My host pc can ping the virtual machine successfully. Other PC's on my home network can successfully ping my host pc and the virtual machine. I have given the virtual machine its own static IP on my network as well.
How do I test if others outside my home office network can see this dev server? Which ip address will point to the dev server in this scenario?
What should I do next so that third party developers can access this server via ftp and/or ssh?


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Indraprastha Apollo Hospitals, New Delhi is part of the Apollo Hospitals Group and is a multi-specialty tertiary care Institute with over 50 medical and surgical disciplines. It is a 695 bedded hospital, offering state-of-the-art clinical services in the fields of Cardiology, Oncology, Neurology, Nephrology, Orthopedics, Urology, Multi-Organ Transplants, Gynecology, Pediatrics, Cosmetic Surgery and Emergency Care to name a few. The latest in breakthrough technology is Novalis Tx,HIFU-High Intensity Focussed Ultrasound for uterine fibroids.
Indraprastha Apollo Hospitals, New Delhi is at the forefront of medical technology and expertise and provides a complete range of the latest diagnostic, medical and surgical facilities for the care of its patients. The hospital brings together some of the most talented medical professionals in the country and has a dedicated team of clinicians to provide highest standards of patient care.
Apollo Hospitals, New Delhi is accredited by Joint Commission International (JCI) USA as the first internationally accredited Hospital in India and South Asia.
Subsequent to the accreditation by Joint Commission International (JCI), USA the laboratory services have also been accredited by NABL. NABL (National Accreditation Board for Testing and Calibration Laboratories) provides laboratory accreditation services to laboratories that are performing tests / calibrations in accordance with criteria based on internationally accepted standards and guidelines.
Apollo Hospitals have always believed in investing in the right technology that will help in improving clinical outcomes and enhancing the service delivery to patients. The latest being a breakthrough technology and a first for Delhi–the 64 Slice CT Angio Scanner and the 3 Tesla MRI which have been installed at Apollo Delhi.


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How Should Catering Company Works
Catering Company: If you have ever went to a gallery opening, bridal shower, rehearsal dinner, book signing or even a bar mitzvah, you have likely had a catering experience. Once you attend an elegantly assigned wedding reception or a plated fund raiser with food as tasty, if not more tasteful than the local dining hotspots, you nearly definitely have a catering team to give thanks.
Catering appears pretty simple and straightforward: You prepare some food and serve it, right? That is the primary thought, but there's a lot to it, a whole lot more.
In this article, we will take you behind the scenes to determine what catering is all about. From the first customer caterer meeting to the big event, catering involves many preparations and planning, creativity, teamwork and some pretty cool equipment.
First, let's consider what defines catering today
Food is unquestionably the star in the catering world, but it is just one part of the formula. Chef Joel Dondis of Joel, a full service catering and event planning company cited in New Orleans, Louisiana, agrees. Like a lot of catering companies nowadays, Joel includes full-event-planning. As catering companies have moved toward the full-service, event planning pattern, the focus has morphed. It is not that food is no longer a central point, but instead that it's part of a larger mission. Dondis suggested that catering is all about satisfying all the senses: hearing, sight, touch, taste and smell.
With the proper atmosphere, you are able to appeal to all of these senses in a sense that makes an event memorable and special. Of course, attractively prepared food could attract to your sense of smell taste, and sight, possibly even touch, but it should not outshine the rest of the event. Caterers today typically wish all piece of the puzzle, from the decor to the glassware, to have that same sort of impact.
How Catering Works
From lighting to linens, tables to tunes and flatware to flowers, everything should complement the food to make an integrated total experience. According to Dondis, continuity is the key. You wish every aspect to be in synchronized with one another. For example:
Does the venue match the climate, occasion and group size? No matter how beautiful the surrounding gardens, you likely would not prefer to have formally attired invitees dining outside in 98 degree weather.
Does the menu match the occasion and tastes of the group? Tappas stations would be an inspired idea, for a retirement celebration, where the retiree is becoming ready to start a 6 month sabbatical in Spain with her spouse.
Does the decor fit the event and venue? White linen, china and crystal stemware may not be the most suited table setting for a casual, pool side barbecue reception. Festive prints, such as white and blue checked tablecloths and matching napkins with plain glass plates and mason jars may be a best match.


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I would like to set up 25 student accounts on a Unbuntu 12.04 LTS VM that I have provisioned via Windows Azure for teaching purposes.
Can anyone point me toward some scripts that would automate this process and also offer some advice which command, newusers or adduser, would be preferable? I would like to set up home directories, basic passwords and the usual config/. files (from /etc/skel?). Students should have limited privileges (ie be regular users). I want to avoid them peeking into each others' accounts :-) [or mine], this implies no sudo either of course (which I assume it the default already for non-admin accounts).
If a script would be necessary, I would prefer writing the script in Python, though I can cobble together and run a bash script too.
Thanks, while I'm quite confident as a user, the admin side for more than myself is a bit new to me. I find the command choices a bit confusing for something that would be a regular admin task.


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Sounds a lot more fun than mowing the lawn. She is a Lady with her priorities in order
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text: Browse Featured Popular Recent Upcoming Speakers Network Like the content on Open? Your friends may as well.Share Open×Areas of Ministry Messages Kids Early Childhood Elementary Extras Early Childhood Archive Elementary Archive Youth 5-6th Grade 6-12th Grade Creative Scripture Art See more... Leadership Worship Operations Finance Human Resources Logistics Small Groups Missions Communications General TopicsEarly ChildhoodFaithLeadershipPodcastWorship Small Groups ShareFight EventAvailable on: Sep 7, 2013Small GroupMenMarriageFamilyHoly SpiritStrengthFailureWarriorBoldnessCourageEventAre you willing to go down without a fight? Because it could be happening. Your marriage, your family, and your heart are in the battle zone. It's time to man up—for God. Help the men in your church uncover who they really are – men created in the image of God with a warrior's heart. Equip the men of your church to fight the battles that matter most; the ones that determine the state of their hearts, the quality of their marriages, and the spiritual future of their families. Fight.View MoreShow only Artwork Audio Document VideoAll Items Artwork PreviewDownloadQueue Artwork (JPG) PreviewDownloadQueue Artwork (PSD) Bulletin PreviewDownloadQueue Bulletin Back (AI) PreviewDownloadQueue Bulletin Back (PSD) PreviewDownloadQueue Bulletin Front (AI) PreviewDownloadQueue Bulletin Front (PSD) Bulletin Artwork PreviewDownloadQueue Bulletin Artwork (JPG) PreviewDownloadQueue Bulletin Artwork (PSD) PreviewDownloadQueue Bulletin Cover (JPG) PreviewDownloadQueue Bulletin Cover (PSD) PreviewDownloadQueue Bulletin Shell (INDD) PreviewDownloadQueue Bulletin Shell 2 (JPG) Flyer PreviewDownloadQueue Flyer Back (AI) PreviewDownloadQueue Flyer Back (PSD) PreviewDownloadQueue Flyer Front (AI) PreviewDownloadQueue Flyer Front (PSD) Invite PreviewDownloadQueue Invite Back (PSD) PreviewDownloadQueue Invite Front (PSD) Mailer PreviewDownloadQueue Mailer Back (AI) PreviewDownloadQueue Mailer Back (PSD) PreviewDownloadQueue Mailer Front (AI) PreviewDownloadQueue Mailer Front (PSD) Promo Video PreviewDownloadQueue Promo Video 1080 CDT (MP4) PreviewDownloadQueue Promo Video 1080 EDT (MP4) PreviewDownloadQueue Promo Video 1080 PDT (MP4) PreviewDownloadQueue Promo Video 720 CDT (MP4) PreviewDownloadQueue Promo Video 720 EDT (MP4) PreviewDownloadQueue Promo Video 720 PDT (MP4) PreviewDownloadQueue Promo Video CDT (MOV) PreviewDownloadQueue Promo Video CDT (MP4) PreviewDownloadQueue Promo Video CDT (WMV) PreviewDownloadQueue Promo Video EDT (MOV) PreviewDownloadQueue Promo Video EDT (MP4) PreviewDownloadQueue Promo Video EDT (WMV) PreviewDownloadQueue Promo Video PDT (MOV) PreviewDownloadQueue Promo Video PDT (MP4) PreviewDownloadQueue Promo Video PDT (WMV) Simulcast Video PreviewDownloadQueue Fight Event 2013 (MOV) PreviewDownloadQueue Fight Event 2013 (MP3) PreviewDownloadQueue Fight Event 2013 (MP4) PreviewDownloadQueue Fight Event 2013 (WMV) PreviewDownloadQueue Fight Event Discussion Guide (PDF)


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Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Released: May 01st, 1995
Running Time: 80
Directors: Gail Force, Jim Powers
Company: Factory Home Video
Cast: Alex Jordan, Vanessa Chase, Sahara Sands, Jasper (I), Rick Masters, Damian (I), Anthony Crane, Kirsty Waay
Critical Rating: AAA 1/2
Genre: Feature
After Sahara Sands fulfills a fantasy by seducing a hunk of a lifeguard, Damian, and having him in her back door as well, the story unfolds. Anthony Crane is on his way out of town, but not before a freshly shaven Alex Jordan has her way with him right in a driveway slamfest. The usual routine follows, but unfortunately he never paves her "assphalt."
While the cat's away, boy, does this mouse play - with the next door neighbor's daughter, Vanessa Chase, in a sensual girl/girler. Alex teaches Vanessa the nuances of vibrators and female togetherness.
At a party later that evening, Kirsty Waay meets up with Kyle Stone and Rick Masters at a steamy three-way intersection. In the aftermath, two cops are summoned. The female officer, Jasper, fiercely frisks Alex and the femme fatales get down to some very steamy action, while Tony Roman, who devours a doughnut, can only watch with a glazed look in his eye. He sits in a pool of green light... could it be an envy thing? Most viewers would envy this kind of 'cavity search' as well.
Like an August evening in Orange County, Laguna Nights is hot and balmy. Stock up, grab a towel and have some fun.


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The Integrated Computational Environment for Airbreathing Hypersonic Flight Vehicle Modeling and Design Evaluation
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AbstractAn integrated computational environment for multidisciplinary, physics-based simulation and analyses of airbreathing hypersonic flight vehicles will be developed. These vehicles are among the most promising alternatives for the next generation of Highly Reliable Reusable Launch Systems (HRRLS). The proposed work will enable development of models with varying fidelity, incorporating the coupled dynamic elements resulting from the tightly integrated airframe-engine configuration. These will include aero-propulsion and aero-elastic interactions as well as thermal loading. The effect of unsteady aerodynamics and nonlinear phenomena such as shock-shock interaction on vehicle performance will be evaluated. Simple and intuitive models for control design as well as high fidelity models for validation and simulation will be developed. The investigators' extensive experience with multidisciplinary software such as STARS and FLUENT will be an asset in this regard. Rather than creating completely new suit of software the approach proposed here is to develop new software when necessary but also produce codes which will enhance the present capabilities of existing software to handle coupled aero-propulsion as well as aeroelastic effects. The methods and products developed in this effort will significantly enhance the present capabilities for modeling, simulation, and control design, for airbreathing hypersonic flight vehicles.
* information listed above is at the time of submission.
An Official Website of the United States Government


text:
- Police/Fire/Courts
- Business
- Local
- State/Northeast
- Nation/World
- 2016 Elections
- Special Reports
- Maps & Data
- Military
- Horoscopes
- Dear Abby
- Games & Puzzles
- Lifestyle
- Events & Exhibits
- Food & Drink
- Arts & Music
- Movies & TV
Detroit - Ryan Radcliff threw an 11-yard touchdown pass to Cody Wilson with 5:11 remaining to give Central Michigan the lead, and Western Kentucky was stopped on fourth down when a field goal would have tied the game in the final minute, giving the Chippewas a 24-21 win in the Little Caesars Pizza Bowl on Wednesday night.
Lance Guidry, coaching the Hilltoppers on an interim basis before Bobby Petrino takes over, decided to play for the win on fourth-and-2 from the 19 with 51 seconds left, but Kawaun Jakes threw incomplete.
Western Kentucky (7-6) fell just short in its first bowl since joining college football's top tier in 2009.
Avery Cunningham blocked a punt for Central Michigan (7-6) to give the Chippewas a short field before Wilson's TD.
Radcliff went 19 of 29 for 253 yards and three touchdowns, but Central Michigan needed to rally late. Zurlon Tipton appeared to have put the Chippewas ahead in the fourth quarter, but his fourth-down run was ruled short of the goal line after a review.
With Western Kentucky still up 21-17, the Hilltoppers had to punt from their own end zone. Cunningham blocked it, and although the ball bounced around for a bit, the Chippewas finally secured it and took over with great field position inside the 30.
Radcliff found Wilson in the back left corner of the end zone for a 24-21 lead.
Western Kentucky's final drive ended when Jakes' pass intended for Jack Doyle fell incomplete.
Petrino, the Hilltoppers' coach-in-waiting, was expected to be at Ford Field watching his new team, but a snowstorm forced him to scrap those plans. Western Kentucky started aggressively.
Down 7-0, the Hilltoppers ran a flea-flicker on their first play from scrimmage, with Antonio Andrews running to his right, then tossing the ball back to Jakes, who found Rico Brown for a 70-yard gain.
Two plays later, Jakes scored on a 6-yard run to tie it.
Central Michigan answered with a 73-yard drive that ended with Andrew Flory's 29-yard touchdown reception, his second of the quarter.
The offenses settled down a bit for the rest of the quarter. Both teams were backed up by a pair of terrific punts. Hendrix Brakefield's 74-yarder pinned Central Michigan at its own 5, but Richie Hogan flipped the field position with a punt that sailed past Andrews and bounced back to the Western Kentucky 12. The 82-yard effort was returned only 4 yards.
David Harman's 50-yard field goal put the Chippewas up 17-7, but Jakes threw a 6-yard touchdown pass to Doyle, with the tight end making a one-handed catch to pull Western Kentucky within three.
The TD pass was the 51st for Jakes, breaking a tie with Justin Haddix atop the school's career list.
Harman had a field goal blocked later in the half, and although the Chippewas were in range for another attempt in the final minute, Radcliff was sacked and fumbled. He was able to recover, but the last few seconds of the half ticked off.
Western Kentucky took a 21-17 lead in the third on a 1-yard run by Kadeem Jones, which capped an 80-yard drive that used 9:23.
Andrews rushed for 119 yards, but he fell short of the 274 all-purpose yards he needed to break the single-season record of 3,250 set by Oklahoma State's Barry Sanders in 1988.
Central Michigan took a 7-0 lead on a 69-yard touchdown pass from Radcliff to Flory. Western Kentucky safety Jonathan Dowling whiffed on a tackle near midfield, and Flory was gone.
Dowling had a chance to make up for that mistake early in the third quarter, but with his team down 17-14, he dropped an interception near midfield that he could have easily returned for a touchdown.
Mad About Madeline Facebook page helped family cope with daughter's fatal leukemia
Waterford beats Keene (N.H.) 4-0 in New England Babe Ruth (13) opener
Trump says he prevented Cruz from being 'ripped' off convention stage
For newest police recruits, helping the community comes first
Casey and The Sports Doctor with Jim Buonocore on schools of choice
Casey & The Sports Doctor: Caroline Taber, rules changes, Matt Harvey
Blue Lives Matter rally postponed after backlash in New London
Trump accepts GOP nomination, promises security, prosperity, a return to 'law and order'


text:
Henry Clerval is a young man who is in his middle twenties. He is Victor's best friend and traveling companion He ends up going to Ingolstadt with Victor. Clerval was not into natural science. He was more interested in foreign languages.
He engaged in Persian, Arabic, and Sanscrit languages and helped Victor become involved. After Victor developed a horrible fever, Clerval was the one to take care of him. Clerval was very good to him and after awhile Victor finally got better.They both decide to go on a long journey for about a year. They saw many beautiful towns, and parts of nature. Clerval loved nature and all it had to offer. After that, Clerval decides to go his separate way for a while, which was not a good idea. The monster eventually got ahold of Clerval and strangled him. The monster killed him just like he did with William. Clerval's body was found on the shore of Ireland. Victor ended up in Ireland and found out Clerval was dead. The monster went after Clerval because he knew how close him and Victor were and how much pain it would put Victor though. After Clerval died, Victor fell ill again.
Cares about Victor
Learns foreign language
Experiences England
Ready for any adventure
Vivid imagination
Almost a family member to the Frankensteins
Learning is his hobby
"Henry Clerval was the son of a merchant of Geneva. He was a boy of singular talent and fancy. He loved enterprise, hardship, and even danger, for its own sake. He was deeply read in books of chivalry and romance."
Henry was a fine, young Gentleman. He was very gifted and a good friend for Victor.
"Alas, how great was the contrast between us! He was alive to every new scene; joyful when he saw the beauties of the setting sun, and more happy when he beheld it rise, and recommence a new day."
In this quote Victor is talking about Clerval. He is describing how happy they were together and how much Clerval loves nature.
Foreign Languages
Mountain Nature
Johnny Cash - I Dont Know Where I'm Bound


text:
For some reason on my tablet (TF101) it won't in landscape but portrait it will.
Angie WimberlyShared publicly -
Is Google Plus ever going to work with SwiftKey X? It never shows predictions/corrections when I'm posting from my phone.
10 comments
Hmm, interesting. Now that I'm typing this, I realize it works when I'm leaving a comment, but not when creating a post.
Ah, we'll guess it's just the Galaxy S II but for all I know another version of it works fine, haha.
Add a comment...


text:
Treating Your Feet Can Help Your Heart
…Sinatra looked at these foot baths with a very skeptical eye. Although the theory seemed plausible, we were both thinking it a bit of a parlor trick that it could energize the body at the same time, despite positive testimonials from people who feel better after using the bath. Then one distributor offered…Read More


text:
Mono Back and Forth: Already Part of GNOME Standard Installation in Lenny
The Debian community has been arguing over the last few weeks about whether Mono should be part of the standard Debian installation. Now it appears that it has already been an integral part of the sofware ever since Lenny.
Debian spokesperson Alexander "Tolimar" Reichle-Schmehl's recent attempt to explain the GNOME project's position on including Mono in the standard Debian installation to FSF's Richard Stallman seems to have run aground. Reichle-Schmehl was mistaken on two counts, he admits in a recent blog.
It appears that the controversial C#-based Mono is already more than recommended in Lenny 5.0. The new Debian installer for Lenny is the gnome metapackage that installs it by default rather than the thinner gnome-desktop-environment used in previous versions that does not. The gnome metapackage pulls in the Mono-based Tomboy note-taking software such that the complete Mono components are installed. Only the CD installation without Internet connection is Mono-free, because Tomboy and its other Mono dependencies aren't included on the CD.
Tolimar would prefer to summarize the situation as, "Debian might install Mono with its GNOME install media, but that can still change." Up to now the dependency on Mono was based on a nonbinding recommendation, although Tolimar suggests your "Joe Average" will now have the dependency choice of Tomboy or the non-Mono Gnote during installation. The dispute over Mono in Debian ignited after Debian developers wanted to extend the simple Mono recommendation to a dependency, so it seems that the dispute might continue for some time to come.
Issue 26: Linux Shell Handbook 7th Ed./Special Editions
Buy this issue as a PDF
SUSE Joins the Microsoft Test Drive Program
Customers can take a free test drive of SLES for HPC on the Azure Cloud
SiFive Launches a Line of Open Source Chips
San Francisco-based chip company announces their first fully open source chip platform.
Fedora 24 Released
The whole distro gets rebuilt on glibc 2.3
Canonical Announces Cross-Distro Support for Snaps
Ubuntu Vendor tries to solve app packaging and distribution problem across distributions.
ownCloud Forked
Founder of ownCloud launches the Nextcloud project.
HP Enterprise Unveils a Futuristic Computer
Will The Machine change the way future programmers think about memory?
CoreOS Announces Distributed Storage System
The new Torus distributed storage system is available under an open source license on GitHub
Google Beats Oracle in the Android Lawsuit
Juries decides Google's use of Java APIs Was Fair Use
Linux is the Largest Software Development Project in History
But if you are not using the latest Linux kernel, your system is insecure.
Linksys Says Yes to Open Source Firmware
Home routers will give room for custom firmware but still comply with FCC rules


text:
Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Released: Dec 18th, 2009
Running Time: 121 Min.
Director: Uncredited
Company: Devil's Film
DVD Extras: Cumshot Recap, Music-Free Option, Still Gallery(ies), Trailer(s)
Cast: Mark Galfione, Celeste (IV) (Trans), Christian (I) (TS-friendly performer), Mandy Mitchell, Jezebel Yum, Vin Deacon, Kelly Shore, Yasmin Lee, Jesse (III) (Trans)
Genre: Trans
Gimmie a C! Gimmie a O! Gimmie a C! Gimmie a K! What's that spell? COCK! That's right COCK!! Tranny Cock that just loves it when the team wins so they can celebrate like only Tranny Cheerleaders can... with hot, raunchy cock sucking and ass fucking. Now you know what the star athletes do in the locker room after scoring in the game... they score with the Transsexual Cheerleaders!!


text:
Illinois Public Media News
In-depth reporting from WILL, NPR, the Associated Press, and other sources
Contact WILL News at firstname.lastname@example.com
Wilson Ring/Assocated Press
July 20, 2016
AP Photo/Matt Rourke
July 19, 2016
GOP Convention; Talking Race, Police & Violence; What's Killing Trees In Illinois?
Amanda Vinicky / WUIS
July 19, 2016
RNC 2016: Mainstream Republicans And The Trump "Newbies"
(Jeff Bossert/Illinois Public Media.)
July 18, 2016
Durbin Slams GOP For 'Politicizing' Zika Virus Funding
July 18, 2016
GMO Labeling Bill; Evangelicals & Trump; Third Party Candidates
Melany Jackson/C-U at Home
July 18, 2016
Current Plight For C-U Homeless Is 'Unprecedented'
Matt Rourke / AP
July 18, 2016
Illinois Delegates At Republican National Convention, Where Truth Is Stranger Than Fiction
Max Becherer/Associated Press
July 17, 2016
UPDATE:Police Killed By Shooter in Baton Rouge; Shooter Also Dead
Page 5 of 1044 pages ‹ First < 3 4 5 6 7 > Last ›
WILL Newscast audio
NPR News
Larry The Lobster, Saved From Stockpot, Dies In Styrofoam Instead
U.S. Navy To Honor Gay Rights Icon Harvey Milk
Maternity Hospital In Northern Syria Is Bombed, Charity Says
They 'Failed': 6 More Michigan Employees Charged In Flint Water Crisis
Uber Hasn't Had An Effect On Drunken-Driving Deaths, Study Finds
U.S. Appeals Court Strikes Down North Carolina's Voter ID Law
Outside Attorney Joining Prosecutors On Philando Castile Shooting Case
'Forgive Us For So Much Cruelty': Pope Francis Visits Site Of Auschwitz Death Camp
U.S. Economy Grew By Just 1.2 Percent During 2nd Quarter
The Economy And Politics Of 1968: Now Playing In Reruns
More NPR News
WILL Highlights
ART/BTS wins 2 Tellys
For the second year in a row, the web series brought home both a Silver and Bronze Telly award.
The 21st
21st century radio for the 21st state. Weekdays at 11 am on WILL-AM 580.
2015 Illinois Public Media Annual Report
Our 12-page Annual Report with highlights of Illinois Public Media's activities in 2015.


text:
Entries in 'Monster Hunter 4 Ultimate' (5)
Capcom produces its lowest annual revenue total in ten years
Capcom has reported its full year financial results for its fiscal 2014, which show a YOY decline of 37 per cent for the publisher.
Nintendo announces three New 3DS hardware bundles
Nintendo has revealed three new hardware bundles for its New 3DS consoles.
Monster Hunter 4 Ultimate ships 1m in the West
Capcom is celebrating a milestone achievement for its Monster Hunter series in the European and American market.
Monster Hunter 4 Ultimate ships 3m copies worldwide
Monster Hunter 4G and its western release Monster Hunter 4 Ultimate have combined to ship 3m units, Capcom has announced.
Monster Hunter 4 Ultimate heads west in 2015
Capcom announced a new title in its popular Monster Hunter franchise today, and this one's getting a western release.


text: Man Who Fell from Sky Night of the White Buffalo Killing Custer Buffalo Bill's Dead Now The Perfect Suspect The Spider's Web Silent Spirit Blood Memory Girl w/ Braided Hair Drowning Man Eye of the Wolf Wife of Moon Killing Raven Shadow Dancer Thunder Keeper Spirit Woman Lost Bird Story Teller Dream Stalker Ghost Walker Eagle Catcher For a downloadable list of the novels in order, click here The Wind River Mysteries Read about the trade edition of the Watching Eagles Soar anthology 2015 2014 2013 2012 2010 2009 2007 2006 2005 2004 2003 2002 2001 2000 1999 1997 1997 1996 1995 Catherine McLeod Novels 2011 2008 A Note from the Author Welcome to my world of mystery novels and short stories set among the Arapahos on the Wind River Reservation. The people who move through my storiesFather John O'Malley and Vicky Holden and everyone in their liveshave sprung straight from my imagination. They are, as Henry James said of his characters, my dream people. But the Arapahos and the setting are real, and you can find out about both on this website. The stories are also real, in that they're based on actual crimes and injustices. Some occurred in recent times, such as the horrific crime in The Lost Bird which I read about in the newspaper. Other crimes are from the pastwhat the Arapahos call the Old Time. The Story Teller, The Spirit Woman, and The Shadow Dancer are all based on events in historyold crimes that have a way of haunting the present, refusing to be forgotten, still demanding justice. All are stories that took hold of me and refused to let go until I'd written about them. Margaret


text:
eSTEP Campaign 02-2011 Material available
By uwes on Oct 19, 2011
We would like to extend our sincere thanks to those of you who attended our Campaign on "Oracle OpenWorld Update".
The materials (presentation, replay) from the Campaign are now available for all of you via our eSTEP portal. You will need to provide your email address and the pin below to access the downloads. Link to the portal is shown below.
URL: http://launch.oracle.com/
PIN: eSTEP_2011
The downloads can be found under tab Events --> Campaigns.
Feel free to explore also the other delivered webcasts and more useful information under the Download and Links tab. Any feedback is appreciated to help us improve the service and information we deliver.
Thanks and best regards,
Partner HW Enablement EMEA


text:
The Art of iPhoneography
By Hachette UK (LBS)
Open iTunes to buy and download apps.
By Stephanie Calabrese Roberts
The Art of iPhoneography, an app of the bestselling book, includes all the original text presented in beautiful graphical and interactive form.
The iPhone is an iconic product, and every one includes a camera, always at hand. This is a book for every iPhone owner with an interest in creating stylish, fashionable, exciting and unique photos, wherever they are.
iPhone users are always talking about the latest 'apps', and with good reason; for pennies, extra features can be added to the phone in seconds, including hundreds of tools for photographers. This book selects the best and teaches how to use them through clear illustrations, inspirational images and a friendly instructional text.
But this is no mere software manual; this is a book to inspire creative photographers. A series of photographic challenges that everyone can undertake will let you gain in confidence and train you to see great opportunities for arresting photos, wherever you are.
iPad Screenshots
Customer Reviews
Great book/app! Worth every bit the money.
- $9.99
- Category: Photo & Video
- Released: Feb 07, 2012
- Version: 1.0.1
- Size: 365 MB
- Language: English
- Seller: Littlehampton Book Services Limited
- © The Ilex Press Ltd.
Compatibility: Requires iOS 4.0 or later. Compatible with iPad.


text:
30 results was found matching keyword
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Báo Tuổi Trẻ English 9 month(s) ago
The number of criminal cases in the suburban areas of Ho Chi Minh City plummeted by nearly 30 percent from 2008 to the first half of 2015 in comparison with that of the preceding period.
Keywords: OfficersPublic SecurityCan GioHoc MonStaringNha Bedrop by
VOV News English 9 month(s) ago 3 duplicate news
(VOV) - A high-ranking delegation from the Senate of the Parliament of the Czech Republic led by its President Milan Stech and his spouse will pay a five-day official visit to Vietnam, staring from November 15.
Keywords: visitStaringforgeNational AssemblyForeign AffairsDelegationpay
Báo Tuổi Trẻ English 9 month(s) ago
3 related news
Myanmar's military-backed government vowed Wednesday to respect the country's election result despite staring at a poll wipeout, as opposition leader Aung San Suu Kyi called for talks with the president and the powerful army chief.
Keywords: Suu KyiThe ArmypartyrespectAung San Suu KyiTalksStaring
Báo Thanh Niên English 9 month(s) ago
It has choked Singapore with smoke, triggered Pacific typhoons and left Vietnamese coffee growers staring nervously at dwindling reservoirs. In Africa, cocoa farmers are blaming it for bad harvests, and in the Americas, it has Argentines bracing for lower milk production and Californians believing that rain is finally, mercifully on the way.
Keywords: Climate Prediction CenterThe U SNational OceanicweatherDecadesEverythingStaring
Báo Tuổi Trẻ English 10 month(s) ago
Crystal tumblers of Kentucky bourbon and Tennessee whiskey, on the rocks. Maine lobster and Maryland blue crabs, garnished with lemon slices. An adorable black Montana steer, staring head on into the camera.
Keywords: The White HousedealObamaTariffsstatereport
Báo Thanh Niên English 18 month(s) ago
The Hue police Sunday said they have arrested a Viet kieu who allegedly killed another bargoer after drinking at a local bar the previous day.
Keywords: allegedlybarStaringViet KieuVietnamese AmericanThe Hue
VietnamNet English 18 month(s) ago
Few thrills rival the sensation of floating through the sky, staring at chasms and valleys thousands of feet below and forgetting that all that stands between you and the ground is a bundle of wires strung between a series of poles.
Keywords: HillsStaringIn DananglongestServes
Báo Đầu Tư English 18 month(s) ago
1 related news
Keywords: StaringBa NaIn DanangStoresHillslongest
VOV News English 18 month(s) ago
1 related news
(VOV) -Few thrills rival the sensation of floating through the sky, staring at chasms and valleys thousands of feet below and forgetting that all that stands between you and the ground is a bundle of wires strung between a series of poles.
Keywords: Staringon earthBa NaIn DananghatHills
VietnamNet English 21 month(s) ago
VietNamNet Bridge – While ambling in an early morning at the Saigon Zoo and Botanical Gardens last weekend, my eyes stopped at a middle-age artist who is surrounded by many pieces of silhouette pictures. My mind flashed back to the old days when I was a little girl, coming here with my mother and asking a shadow cutter make us silhouette portraits as commemorative items for the trip. Even back then and now, I cannot help staring at the artist...
Keywords: Saigon ZooBotanical GardensshadowVendorsPicturesjobweekend
Báo Thanh Niên English 22 month(s) ago
1 related news
The Directorate for Roads of Vietnam has announced plans to issue international driving permits to local residents and recognize licenses held by foreign drivers staring in 2015.
Keywords: permitdrive inQuyenHolderssamplerecognizeThe Road
Báo Thanh Niên English 22 month(s) ago
Long periods of staring into welding flares have seriously damaged Nguyen Van Bang's vision.
Keywords: sufferDiseasesPublic HealthmineStaringbangUnsafe
Báo Tuổi Trẻ English 23 month(s) ago
Tuoi Tre News briefs you on some of the main stories published today, October 2, in Vietnamese media
Keywords: The UnionVo Van ThuongInternational DayBinh LoiStaringDegradedStories
VOV News English 25 month(s) ago
4 related news
(VOV) - Japanese encephalitis, a mosquito-borne disease that preys on young and malnourished children, has claimed ten lives out of to 84 reported cases in Son La province since the beginning of this year.
Keywords: Son LalistlesslyStaringBorneSon La ProvinceProvincial Department
Báo Dân Trí English 26 month(s) ago
Nearly 200 workers of Shin Dong Textile Ltd. Co. in HCM City were hospitalised on July 1 evening after taking their dinner at the company.
Keywords: ImagesStaringafterSymptomsThe General HospitalDoctors
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Mike Woodhouse
Canon EOS400D user for a couple of years now, idly contemplating an upgrade to 5DMkII or 7D but in no hurry: there's plenty of scope for improvement in technique before a better camera is needed.
I also keep a little Fuji S1500 in my desk at work for days when I can get out at lunchtime for an attempt at a theme from www.dailyshoot.com
- London, United Kingdom
- grumpyop.wordpress.com
- Member for 6 years
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- Last seen Mar 10 '14 at 14:51
Keeping a low profile.
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posted on: 2/6/13
I am looking for someone able to tutor cell biology. I have a midterm coming up and am lost.- Shannon from La Jolla, CA
Over the last seven years we've built the largest and most trusted tutoring marketplace on the web. With a new student lead posted every minute, WyzAnt eliminates the need to be listed on multiple sites.
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You don't have to worry about marketing, collecting payment, or unqualified leads on WyzAnt. We take care of all the details so you can focus on tutoring!


text:
July 28 2016
Mayor & CouncilCouncil AgendasBy-LawsMunicipal DepartmentsEmployment OpportunitiesMunicipal Elections
Building ServicesPlanning DepartmentBy-Law Department Dogs - Licensing & ControlEmergency PreparednessGarbage & Recycling Mattawa Water WorksPublic Works Department Recreation DeptartmentWater Bills and TaxesWinter MaintenanceFire Fighting & Prevention ServicesJohn Dixon Public LibraryMattawa GIS Maps
MBEDCDevelopment: Planning & ZoningMunicipal Tenders Mattawa RecorderMunicipal Performance Measures
About MattawaMattawa Voyageur CountryVoyageur DaysEcology CentreVMUTS
Water Bills & Property Tax InfoEmergency ServicesRecreationChildren, Youth and Family ProgramsJohn Dixon Public LibraryChurchesSchool BoardsHealth Services
Welcome to the Town of Mattawa
Meeting of the Rivers. We are Mattawa. Welcome!
We are a mixed french/english speaking community that offers services in both official languages. Restaurants, trails, arena, fitness facilities, and much much more. We take pride in providing community services that fosters growth and developement.
Please use our website as a tool to answer some questions you may have about our community. If for some reason there is something we don't answer here, please feel free call us at 705-744-5611 or email us email@example.com. We will be happy to answer your inquiry.
We can't wait to hear from you!


text:
Created in this Craftsy class
Craftsy Block of the Month 2012 taught by Amy Gibson
In Craftsy's first-ever Block of the Month, Amy Gibson brings you 10 specific quilting techniques - appliqué, string quilting, paper piecing and more.
Other projects made as part of this class:
QuiltingPinwheel blocks
QuiltingModern sampler quilt
Quilting2012 BOM Amy Gibson - Two lap quilts
Offer some kudos...
Join the conversation...
Ask a question...
Add your comment...
Pretty colors!
08/30/2012 Flag
Thank you Jeya.
08/30/2012 Flag
I really do like the fabrics you are choosing - they are so pretty and your blocks are so good.
10/14/2012 Flag
Thanks. I'm learning and started out doing scrappy but then realized I maybe could do this and started choosing colors a bit better. It will be a crazy quilt but I'll love it.
10/14/2012 Flag


text:
Statewide Voluntary Preschool Program for Four-Year-Old Children
On this page...
The purpose of Iowa's Statewide Voluntary Preschool Program for Four-Year-Old Children is to provide an opportunity for all young children in the State of Iowa to enter school ready to learn by expanding voluntary access to quality preschool curricula for all four-year-old children. The allocation of funds for the Statewide Voluntary Preschool Program is intended to improve access to quality early childhood education and provide a predictable, equitable and sustainable funding method to increase the number of children participating in quality programs. Therefore, the four-year-old preschool funds are intended to increase the number of children participating in quality programs.
Awarded Applicants
In the 2016-2017 school year, 322 of 333 districts will participate in the program. In 2015-2016, the certified enrollment count was 23,141.
Voluntary Preschool Map 2016-2017 (2016-06-09)
The following guidance can assist participating school districts and community partners:
- FAQ for Implementation (2016-07-12)
- Compulsory Attendance for 5-year-old Students
- Finance Guidance - Statewide Voluntary Preschool Program (2016-07-12)
- Finance FAQs for the Statewide Voluntary Preschool Program (2016-07-12)
- Transportation - Participating School Districts must work within the transportation guidelines of Iowa Code section 285.10.
Legal Requirements and Reports
The Statewide Voluntary Preschool Program for Four-Year-Old Children was established May 10, 2007. The program provides an opportunity for all young children in the State of Iowa to enter school ready to learn by expanding voluntary access to quality preschool curricula for all four-year-old children.
These rules implement the Statewide Voluntary Preschool for Four-Year-Old Children created in Iowa Code chapter 256c by Iowa Acts 2007 (HF 877). They provide guidance to school districts in the implementation of the program.
The Statewide Voluntary Preschool Program rules are found in 281--Iowa Administrative Code 16.
Statewide Voluntary Preschool Programs for Four-Year-Old Children 2015-2016 Preliminary Report (2016)
Program Requirements
Meeting Program Assurances and Requirements - Provides information to assist districts in meeting program requirements and the assurances.
GOLD Online Assessment System
Iowa Code section 279.60 requires districts to assess all preschool children with the GOLD online assessment and maintain local agreements with Teaching Strategies, Inc. under the GOLD State Service Umbrella Agreement. This includes any preschool-aged child enrolled by a parent in a district program.
The Iowa Department of Education (DE) has a statewide license for Teaching Strategies GOLD through an umbrella agreement with Teaching Strategies, Inc. This agreement provides the GOLD online assessment system and reduces the subscriber fees for all state and federally funded early childhood programs and services, including Iowa school districts, their community partners, Shared Visions, as well as Head Start, Area Education Agencies and other programs located in the state of Iowa. This web‐based online system allows programs, as well as AEAs and the DE, to assess child progress based on research‐based widely held expectations from birth through kindergarten and provide reports at the individual, group, regional and statewide level.
To subscribe to the Teaching Strategies GOLD complete the form located at this link: https://www2.teachingstrategies.com/page/GOLD_StateIowa.cfm
Iowa GOLD Online Procedures (2015-08-01) - GOLD administrators are encouraged to use the Iowa GOLD Procedures document to assist them in setting up and using GOLD online.
End of Year Data Clean-up Guide for Teaching Strategies GOLD Online Administrators (2014-04-14) - Steps to close out the year for GOLD.
Meeting Reporting Requirements Webinar - Provides information districts need to report timely and accurate information.
Guiding Practices
The following are guiding practices that can assist participating school districts and community partners.
Iowa Early Learning Standards/Child Standards
Participating school districts in the Statewide Voluntary Preschool Program for Four-Year-Old Children will follow the Iowa Early Learning Standards. These standards identify the knowledge, skills, motivation, and attitudes needed by preschoolers that lead to success as students enter school and as adults. The developmental areas are:
- physical well-being and motor development
- approaches to learning
- social and emotional development
- communication, language, and literacy
- mathematics and science
- creative arts
- social studies
Iowa Early Learning Standards 2012
Program Standards
Programs participating in Statewide Voluntary Preschool Program for Four-Year-Old Children must meet one of the following program standards. Each standard is indicative of high quality programming efforts. Preschool programs meet or will meet quality standards within 12 months of implementation of the preschool program.
- Head Start Program Performance Standards
- National Association of Education of Young Children (NAEYC) Standards and Criteria
- Iowa Quality Preschool Program Standards (QPPS)
- High Quality Preschools Issue Brief
Iowa Quality Preschool Program Standards Webinar - Provides information on the Iowa Quality Preschool Program Standards (IQPPS) and Criteria, and the IQPPS Verification Process.
Staff Qualifications and Staff Development
Staff Development
Participating school district teachers will receive professional development focusing on areas appropriate to the role of an early childhood teacher and implemented in accordance with Iowa Code section 284.6. School districts will also make appropriate professional development opportunities available to community partner teachers of the preschool program who are not employed by the district. District support staff working in four-year-old preschool classrooms should also be provided opportunities for staff development in early childhood education. These opportunities are to be addressed in the school district career development plan and follow the Iowa Professional Development Model.
Teacher Quality
Numerous studies have found that the education levels of preschool teachers and specialized training in each childhood education predict teaching quality and positively affect children's achievement of social, emotional, language, literacy and cognitive skills. The Iowa Department of Education provides both research and policy guidance in this Issue Brief.
Preschool Teacher Assistant Qualifications
The type of preschool program and required program standards determine the type of qualifications required for teaching assistants. This document provides options that are open to teaching assistants for meeting state and federal requirements.
Qualifications for Preschool Teacher Assistants (2014-08-06)
IQPPS Verification
On-site Visits 2015-2016
- 2015-2016 IQPPS Verification Visits
- IQPPS Complete Criteria Summary
- IQPPS Verification Visit Checklists (revised 2010-2011)
AEA Contacts
Each Area Education Agency has Early Childhood Consultants that can provide information and support to local school districts as they plan for the Statewide Voluntary Preschool Program for Four-Year-Old Children. Contact information is provided in the following document:
AEA Early Childhood Leadership Network
Statewide Voluntary Preschool Program for Four-Year-Old Children requires participating school districts to maintain local agreements with Teaching Strategies, Inc. under the GOLD State Service Umbrella Agreement and assess all preschool children with the GOLD online assessment. This includes any preschool-aged child enrolled by a parent in a district program.
- Information on Teaching Strategies GOLD online assessment can be found at https://www.teachingstrategies.com/page/GOLD-assessment-online.cfm.
Statewide Voluntary Preschool Program for Four-Year-Old Children requires participating school districts to adopt a research or evidence-based curricula that is developmentally appropriate, including age appropriate, individually appropriate, and culturally appropriate. In order to meet the needs of the diverse population of children, families and communities; curricula should be culturally sensitive and flexible.
The Iowa Department of Education does not endorse any one preschool curriculum. Commonly used, commercially developed curriculum packages that meet the above criteria include:
- Creative Curriculum for Preschool http://teachingstrategies.com/curriculum/
- High Scope http://www.highscope.org/Content.asp?ContentId=63
Curriculum Decision-Making
The National Institute for Early Education Research (NIEER) outlines dimensions to consider when making decisions about preschool curriculum in this Policy Brief.
Best Practices in Curriculum, Assessment & Program Evaluation
The National Association of the Education of Young Children (NAEYC) has a Position Statement on Early Childhood Curriculum, Assessment, and Program Evaluation to guide implementers of early care and education programs.
Hiring Licensed Teachers
The TeachIowa.gov website is an avenue to recruit licensed teachers for the preschool program:
- School districts can post job vacancies and search applicants' resumes.
- Early childhood teachers interested in these jobs can search for jobs and share information with School Districts through the online application.


text:
I have spent 9 years tutoring. I began in high school, where I regularly tutored in math, writing, reading, and French, among other subjects, and continued in college. Along the way, I sometimes tutored students in standardized test-taking, public policy, finance, economics and econometrics, Russian, data analysis, and other subjects.
I was born and raised in Chicago, my favorite city in the whole wide world -- so much so that I stayed here for college (University of Chicago). I am double-majoring in economics and public policy with a minor in French, and also participate in a competitive business program on campus.
I love dancing flamenco and teach and choreograph it on campus. I sing with a Russian folk choir and do a lot of work off-campus with Chicago's Russian community. I love reading and writing short stories in my spare time, as well as traveling, cooking, and taking photographs around Chicago.
I tutored algebra for four years in high school and still occasionally teach students informally.
Basic Math
I have tutored basic math for the past 10 years or so, both formally in school and informally.
I have tutored beginning and intermediate levels of French reading, writing, and speaking for the past 10 years or so, both formally in school and informally.
I have tutored pre-algebra for the past 8 years or so, both formally in school and informally.
I am a native Russian speaker and read and write fluently in the language. I have tutored in this subject, formally and informally.
- Aggregate: 2170
- Math: 710
- Reading: 670
- Writing: 790
- Aggregate: 34
Subject: Russian
Chegg Tutors asked:
Why study Russian?
Sonya responded:
Russian is among the most difficult languages in the world. Beginning with a totally different alphabet and ending with numerous grammatical rules that don't exist in English, Russian is a complex but absolutely fascinating language. In these days of international economics and global conflict, it is becoming a useful language on the political, social, and economic arenas.
Subject: ACT
Chegg Tutors asked:
Why study ACT?
Sonya responded:
The ACT is, along with the SAT, a popular standardized test, which many colleges require during the admissions process. Simpler and more straightforward than the SAT, it consists of English, Reading, Math, and Science sections. It is not difficult to prepare for this exam, but practice in advance of test day is recommended.
Subject: GRE
Chegg Tutors asked:
Why study GRE?
Sonya responded:
More and more, the GRE is becoming an important assessment used by graduate schools during their admission processes. Lying between the SAT and the GMAT on the difficulty spectrum, it is much more linear than the GMAT, but slightly more logic-based that the SAT. Students will most likely end up taking the GRE at some point during their college careers, especially if they plan to attend a Masters/PhD program of study (and even business schools have started to accept GRE scores).


text:
About Me: I am contributing as a co-editor of "Krishi Patrika"- an agricultural newspaper published fortnightly in Nepali language from Nepal. As you are well aware that Nepal is and agricultural based poorest country in the world. Out of the total population (28 million), over 80 percent are farmers and more than 90 percent women support in farming and agricultural activities. The status of farmers as well as women is very miserable. Also, we don't have any newspaper publishing news about agricultural activities and farmers voices. So we formed a small group and are publishing agricultural newspapers targeting to rural farmers, since last 16 December 2007.
I hold Massters degree and also studied agriculture. I am tryining to create awareness among rural farmers especially women and raise problems faced by the farmers as well as publish lessons learned by the farmers for its replications. This "Krishi Patrika" is only one of its kind in Nepal published from private sector. With poor resources we are trying to give voices to the voiceless poor farmers and women. We are not a political organisation and also not for profit making organisation. Pease feel free to contact me at email@example.com or firstname.lastname@example.com you can also visit our website <krishipatrika.cfsites.org>.
My Passions: Empower rural farmers and contribute to eradicate rural poverty
My Challenges: Wiiden activities and sustainable development of my newspaper "Krishi Patrika".
My Vision for the Future: Every rural farmers who plough the lands should have enought to feed
My Areas of Expertise: Reporting agricultural news, editing articles (Nepali), management and organisation
Dear Sumitra, 'Namaskar' I am Sunita from Nepal but currently studying in AUW (Asian University for Women) in Bangladesh. How are you? I read your article and am impressed with it. I believed you too wanted to change the womern's lives. I have planned to organised a informal meeting after going back to nepal. The meeting will focus on how to educate all girls in the context of Nepal. I will mentioned the place later. If you wish to join me please feel free to reply the post and let's start our conversation. Thank you With Love and Regards Sunita Basnet
With Love and RegardsSunita Basnet
Thanks Sunita,
When you are coming to KTM ? plz let me know. As u know I am in Kathmandu the best place to at KTM, i love to join your program ,
Dear Sumitra, Thanks for your acceptance. I will inform you the program details later. Can I have your contact information please so that I can inform you about the program. I will discuss with other friends and let you know. Thanks With Love and regards Sunita Basnet 01731894557 Asian University for Women 20/A M.M. Ali Road Chittagong Bangladesh.
With Love and RegardsSunita Basnet
you can contact me trough email and/or call me at 9841345082 (cell) and or 4460861 Res
Dear Sumitra, thanks for your reply. I am talking with my friend in Nepal so there is a probability that the meeting will held on 19th july 2009, in TIA Trungram International School foundation, Hattigauda, Kathmandu. I will inform you as soon as I hear from my friend. Thank you With Love Sunita
With Love and RegardsSunita Basnet
Dear Sumitra Ji, Namaskar How are you? Hope you are doing great work. Please contact me in my gmail account. I need to talk with you.
Thank you
With Love and RegardsSunita Basnet


text:
The eastbound lanes of the QEW have reopened after a tractor trailer rollover at Erin Mills Pkwy.
The accident happened at about 1:30 a.m. and cleanup took until about 11 a.m.
No injuries were reported.
The rollover was expected to cause some major traffic headaches as the morning rush began.
It's not clear what caused the crash.
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text: Apartments Jurina is located in Krk and offers air-conditioned apartments and studios. Surrounded by greenery and lush vegetation the garden features sun terrace and barbecue facilities. A pebbly beach is only 200 metres away. All accommodation comes with free Wi-Fi, cable TV and a fully equipped kitchenette with dining area. Guests can relax on furnished balconies and patios overlooking the sea or the garden. Free private parking is possible on site. The centre of Krk can be reached within 500 metres. Numerous beaches surrounded by pine forest can be found near the Jurina. Apartments Jurina is a good starting point for exploring the island of Krk. Towns of Stara Baška, Vrbnik and Malinska are within 12 km. Valbiska Ferry is 10 km away and takes tourist to nearby islands of Lošinj and Cres.


text:
Vicente Calle
tel: +34.91.514.52.00
Send an Email
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Local Time: Sun. 14:52
EducationDegree in Law, Universidad Complutense (Madrid).
Associate's Degree in Labor Law, Universidad Complutense (Madrid).
Diploma in Accounting and Accounting Procedures, Madrid Chamber of Commerce.
Diploma in Tax Law, Madrid Bar Association.
Professional Associations
- International Bar Association
Professional Activities and Experience
Teaching Experience
Lecturer, Master's Programs (Human Resources and Corporate Advisory Services), Centro de Estudios Garrigues, delivering seminars on corporate restructuring.
Lecturer for three years on the Madrid Bar Association's labor law course for duty lawyers.
Regular speaker at:
American Bar Association (International Committee, labor section).
International Bar Association (Labor and Employment Committee).
European Lawyers Association (EELA).
He has also spoken at conferences on the labor law aspects of the new Tobacco Law in Madrid, Valladolid and Oviedo. October 27, 2006: "Corporate social responsibility in restructuring operations" (*), organized by Eurogroup at the Madrid Bar Association.
October 31, 2006: "Cross border European employment Law", organized by Lexis Nexis, London.
(*) originally given in Spanish. For further information, see Spanish version of CV.
Articles and Publications:
Various articles in the press including the business reviews "La Gaceta de los negocios" and "Cinco Días". "Corporate restructuring operations" (*), Garrigues Law Collection, published by Marcial Pons, Madrid 2007 (release pending). Author of chapters "Collective lay-offs" (*) and "Labor law aspects of the Insolvency Law
(*) originally published in Spanish. For further information, see Spanish version of CV.
© Garrigues, 2016


text:
FWIW I went out and purchased a nicely used Saiga .308 sporter carbine yesterday. Using the old rules its not an "assault weapon". If things calm down I will convert it.
This is a discussion on Most important reason to oppose a new AWB? within the The Second Amendment & Gun Legislation Discussion forums, part of the Related Topics category; Originally Posted by 38special were created by the government and can be "uncreated" with enough passing votes. If the Second Amendment is repealed then the ...
Target Shooting
Varmint Hunting
Home/Personal Defense
Countervailing force against foreign enemies
Countervailing force against tyranny
Trust in God and keep your powder dry
"A heavily armed citizenry is not about overthrowing the government; it is about preventing the government from overthrowing liberty. A people stripped of their right of self defense is defenseless against their own government." -source
FWIW I went out and purchased a nicely used Saiga .308 sporter carbine yesterday. Using the old rules its not an "assault weapon". If things calm down I will convert it.
"There is only one basic human right, the right to do as you damn well please. And with it comes the only basic human duty, the duty to take the consequences." ~ P. J. O'Rourke
Most people would say the first amendment was incorporated in NAACP v. Chicago in 1958, and since that time states have been forced to follow the amendment. The 4th Amendment was incorporated in Wolf v. Colorado and then altered and strengthened in Mapp v. Ohio.
All of that said, the only time that you could say the 2nd Amendment has been incorporated was in McDonald v. Chicago in 2010. However the decision was not worded in such a way as to invalidate any and all gun control laws. Thus the laws that were already on the book will remain valid unless/until they are challenged and a court over turns them. Thus California limiting magazine capacity is still a valid restriction. Since there's a valid legal argument to be had about whether limiting the size of a magazine would infringe upon your right to own a firearm there would have to be a huge case to decide the matter, and through California is not the route that any pro-gun person should choose to take the case.
"The only people I like besides my wife and children are Marines."
- Lt. Col. Oliver North
Fighting tyranny - both foreign AND domestic.
I voted, but frankly could have chosen "all of the above" as an option.
However in reality, I don't need a reason...
"The only people I like besides my wife and children are Marines."
- Lt. Col. Oliver North
As an attorney, I felt I should chime in with my two cents regarding the California gun laws.
Echo is correct as far as the the incorporation of the Second Amendment on the states with McDonald and that in order to challenge California's laws somebody would have to mount a legal challenge to it and it has to reach SCOTUS for those laws to get overturned. It is also correct that despite the Heller and McDonald cases most current gun restrictions are currently upheld by federal courts. Some are not, such as the recent 7th Circuit Court of Appeals overturning the Illinois CCW ban as unconstitutional.
The problem with the Heller decision is that it did not set any firm boundaries on what gun control laws are acceptable. The only central holding of that case is that the Second Amendment is an individual right, not a collective right. They set forth no test of how to decide whether or not gun related legislation is unconstitutional other than to say that an outright ban on a "class of arms in common use by the American people for defense is unconstitutional" so the DC ban on handguns was not constitutional. They also did not define "arms" in American legal terms.
Heller was a great victory for gun rights but also has left a lot of unanswered questions. In the majority opinion they clearly state that Heller did not overturn longstanding gun control laws such as laws preventing felons or the mentally ill from having firearms. Because of that the California laws still stand because nothing in the Heller decision or the subsequent McDonald incorporation renders them unconstitutional. They do not say at what point a gun control law will be determined as unconstitutional. In the future they will determine these limits. If the Seventh Circuit CCW case comes before the Court it will be critical in determining the scope of state gun control laws.
All of that said, in my opinion upon reading Heller numerous times, I don't think another Federal Assault Weapon Ban will stand up under Court scrutiny. Semi-Automatic Assault Rifles are in common use by the people, and it is the Gun Control proponents themselves that are saying they are their own class of arms. Under their own definition and applying the Heller precedent, you would have to say that a ban on them is not constitutional. Are magazine capacity limits unconstitutional? Not right now, and not if they continue to use the same rationale as in Heller.
I predict the Court will hear more cases on gun control in this decade, set up a firm test to decide if gun control legislation is constitutional such as how they use the rational basis test to determine if legislation violates the Equal Protection or Due Process clauses or how they use the imminent lawless action test to determine if legislation violates the First Amendment. Ten years from now, we will have a far greater understanding of the scope of the Second Amendment.
Last edited by relentless; December 21st, 2012 at 09:08 PM. Reason: Typo
The most important reason is simple. An AWB violates my constitutional RIGHTS.
It's funny that Obama is pushing for one, as he claims to be a constitutional scholar. Granted, nobody can actually prove he even attended college.
The fact that your constitutional rights are being stripped away every day and nobody is doing jack about it should absolutely frighten you, and fill you with rage.
My metal band: Born under Sirius
Glock 23, mic holster, clipdraw, abdominal carry.
Freedom - America is only kind of free, but more so than any other country.
The NRA and other groups should not be * defending * our position, but instead; we should be MORE AGGRESSIVE in filing suit against our government and these organizations who are indeed, infringing upon our guaranteed 2nd Amendment rights!
Boomer Sooner!


text:
Does a growth in M2 cause or imply an increase in inflation? 7 commentsOct 14, 2011 6:47 PM
We've recently seen a growth in M2 in the USA. Should we expect a growth in M2 to lead to an increase in inflation?
M2 and CPI data can be obtained from St Louis Fed:
Here is a plot of growth in M2 and seasonally adjusted CPI
Taking data back to the start of the M2 series in 1980 the equation of line of best fit is 3.14488 - 0.00672425 x and the data has an R squared of 0.000152817.
For the USA there is no link whatsoever between M2 growth and CPI over the entire period of M2 data being published.
Interestingly, visually the FRED chart looks to be showing an inverse correlation between the CPI and M2 growth from about 1996/97 through to 2010. Rises in M2 growth seem to coincide with falls in the CPI. That (negative correlation) is indeed the case, though weak, as the plot of data from that period shows:
What of the possibility that inflation lags M2 growth? In other words isn't it reasonable to expect that as M2 growth increases the "surge" in inflation would be observed at some point later on rather than being coincident to the M2 growth?
In the next plot I take a lag from zero to 120 months and measure the correlation (blue line slope, purple line r squared). We can see that a weak positive correlation begins to exist from a period of 45 months through to 90 months. Could we attribute causation to a correlation with such a long lag? Beats me, but I would have thought it was doubtful.
I've also made plots of 12, 18, 24, 36, 48, 60, and 90 month rolling correlations. Here are a couple of samples:
It seems to me that no case can be made that growth in M2 is likely to lead to an increase the CPI. On the contrary the data suggests if anything the reverse is more likely to be observed. Myth busted.
Post script: it was put to me that it is not surprising that I am not seeing a relationship between M2 growth and the CPI because I am using headline CPI. So without further ado here are the charts using CPI ex food & energy.
M2 growth and inflation? Nothing to see here. Move along.
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untrusting investor, contributorComments (9903) | + Follow Following - UnfollowInteresting. Thanks for posting. Believe that inflation is not likely to be a real problem for at least the next few years, but could well become a significant problem later in the decade. Just looks like delevering could predominate for a few years yet, but eventually that will give way to credit expansion and inflation.
Ben and Jerry's, $3.49 three years ago at 7-11; Today $5.95 (LA prices). Real problem. What's the price curve on dinner at Morton's these days? Glad about the delevering from here though. Should investors EASE in here? Did you check out Scott O'Neil's article that I suggested?:
untrusting investor, contributorComments (9903) | + Follow Following - Unfollow
Just read this now. Appreciate this article a lot. As I've always thought about it, M2 is a better indication of money demand rather than supply. It's dominated by short term investment money/market type instruments, which balloon in principal amount when investor demand for money rises. I think that explains the negative correlation you see. mzm and other data series are better supply indicators.
Conventional Wisdumb, contributorComments (1800) | + Follow Following - UnfollowM2 is one part of the equation, the other is velocity.
correct. by definition if the money supply is expanding but the price level is not increasing as much then you have a velocity issue -- but this is circular because velocity, as you point out, is not measured independently.
Codelco output up 5.7%: http://bloom.bg/lGcNVi pundits tell us that there are supply shortfalls and lower grades blah blah blah. May 27, 2011
Labor has claimed victory in the Australian election. This means the Labor-Green alliance will govern. A disaster for miners. Sell. Sep 7, 2010
Reports from Australia that the BHP Rio Tinto iron ore joint venture will not get regulatory approval. Aug 19, 2010
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Loss of Lives in Clinical Trials...
Researchers Now Have a Myriad of...
Co-Sourcing Improves Pharmaceutical Laboratory Productivity
Keep the Opportunities, Lose the Opportunists
Merck & Co. is paying AiCuris €110 million (about $142 million) up front for exclusive global rights to the latter's portfolio of human cytomegalovirus (CMV)-targeting candidates, including lead orally administered drug letermovir (AIC246), which has successfully completed a Phase IIb trial for treating and preventing CMV infection in transplant patients. Under terms of this first development deal for AiCuris, the German firm could receive development, regulatory, and commercialization milestone payments of up to €334.5 million (roughly $433 million), plus additional sales royalties. The pipeline acquired by Merck includes letermovir, an additional backup drug, and other Phase II-stage CMV candidates designed to act via a different mechanism.
Letermovir is a quinazoline-derived drug designed to inhibit the CMV viral terminase. It has been granted orphan drug designation in the EU, and orphan drug and fast-track development status in the U.S. Positive data from a Phase IIb study evaluating the drug in CMV-seropositive bone marrow transplant patients were reported in April.
AiCuris was established in 2006 as a spin-out from Bayer HealthCare's anti-infectives unit, and is focused on the discovery and development of antiviral and antibacterial drugs. The firm's preclinical and clinical pipeline includes candidates against CMV, HSV, HIV, hepatitis B and C, and nosocomial infections. Partners/licensees are being sought for a Phase III-ready HSV compound (AIC316), and two immune modulator programs, one targeting viral hepatitis B and C and fibrosis, and the other against autoimmune diseases.
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MDMA (commonly known as the empathogen "ecstasy") is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.Do you agree that ecstasy should be studied for its potential therapeutic benefits?
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Document scan to Microsoft Word
I have an all-in-one HP C309 g-m. I want to scan a document into my Microsoft Office Word as a document file. About the closest I have come is to get it into the computer as a pdf document which I cannot edit. I used to be able to scan in document with my old HP psc 1210 as it had a little HP director program which allowed me to select if it was a photo or ducument. No such luck now. I need help. Thank you in advance.
Sven Engblom
Re: Document scan to Microsoft Word
I have the same problem as Sven (Mac 10.6 os) Could do this on my old HP F2235 but no software provided for the C309.
Help too.
Re: Document scan to Microsoft Word
Sven, you may have the answer to this by now.
HP do not include OCR software with their latest printers as in the past.
If you can scan it (probably via Preview) as a pdf, then open the pdf in Adobe Acrobat and save it as a Microsoft Word document. This works well.
Re: Document scan to Microsoft Word
Terry Lobban,
Thank you ever so much for your spot on hint of how to scan a document into MS Word using the PDF format. I don't normally use PDF other than reading some documents so I don't know much about that program. I will now. Thanks again
Sven Engblom
Re: Document scan to Microsoft Word
Tery, I was reading Sven's problem & your answer just may be what I too am looking for. I have a Officejet Pro L7780. My problem (I think) is my new computer with Windows 7. With my old Vista I could scan to doccuments with no problem. However I can't figure out how to do it with this new program. On the Vista I had a HP Solution Center that walked me through anything I wanted to do with my printer. But not so with this Compaq/Windows 7. I think I am going to try doing it your way & see what happens. It can't be any worse than it is now. Wish me luck. And thnks for the information & leting us pick your brain.
Re: Document scan to Microsoft Word
Need direction to scan doocument to be emailed
- Testing Your HP Fax Machine with the HP Fax Test Service
- A Communication or Connection Error Displays When Scanning
- Scan Using Full Feature HP Software (Windows 10)
- HP Photosmart 7510, 7515, ENVY 110, 114 Printers - Restoring eFax Service
- HP All-in-One Products - A 'Scanner Failure' Message Displays on the All-in-One Control Panel and You Cannot Scan, Copy, or Fax


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Southern Cross the Dog (Hardcover)
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In the tradition of Cormac McCarthy and Flannery O'Connor, Cheng's literary debut explores the bonds between three childhood friends that are upended by the Great Mississippi Flood of 1927.
About the Author
Bill Cheng received a BA in creative writing from Baruch College and is a graduate of Hunter College's MFA program. Born and raised in Queens, New York, he currently lives in Brooklyn with his wife. Southern Cross the Dog is his first novel.