text:
New iPad mini cases pictured as manufacturers prepare for launch, strange new rear hole appearsPocket-lint
Apple accessory manufacturers are ramping up production in anticipation of the arrival of the iPad mini some time before Christmas. Australian case, cover and bag company Toffee has led the charge by showing two of its leather-finished numbers to Pocket-lint at the CU Exposed tech show in London.
Sitting among the rest of its iPhone 4S, iPhone 5 and new iPad wares were prototypes for the iPad mini in the Shell and Folio range of case design.
The first, the Toffee iPad mini Shell, is simply a back case cover for the predicted tiny tablet complete with edge-to-edge genuine leather finish, while the Toffee iPad mini Folio is a complete case solution. Each follows the currently expected 7.85-inch screen proportions with a space on the Shell for the camera, dock connector, speaker and volume controls.
There's also a strange new hole on the rear that we're currently mulling over in Pocket-lint Towers. Could it be for an IR sensor, showing that Apple is further going for the second-screen market? Could it be for a speaker? Or, perhaps more likely, an LED flash for the camera? There doesn't seem to be one next to the lens, so that's our strongest bet.
Either way, the manufacturer claims that we won't have long to find out.
"These are prototypes but we're expecting the iPad mini soon and we want to show people that we're ready to go as soon as it's announced," we were told by Toffee executive Natasha Sullivan.
With some expecting the iPad mini to be positioned as a gaming device, Pocket-lint's concern was that the more mature, leather styling that the Sydney-based company is known for might not be something that appeals directly to a younger generation but, according to Sullivan, that's not a problem.
"We really think that the iPad mini is going to be something that women will love. The new iPad is too big to fit in most handbags but the smaller size will be perfect and the Toffee cases will complement them very nicely indeed," she said.
You can find out more about Toffee's cases at www.toffee.com.au.
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What do you think the new rear-mounted hole is for? Let us know in the comments below...
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Updated Sep 11, 2013 - 2:16 pm
1 dead in collision at Northern, Seventh Street
PHOENIX — A woman has died and a handful of other people, including her family, were injured in a two-vehicle accident early Wednesday in north central Phoenix.
Police shut down Seventh Street at Northern Avenue in all directions for several hours to investigate what caused the collision between her car and a truck.
The woman, 30, ran a red light, said police. Passengers were her boyfriend and their children, 4 and 3. Each had been strapped into a car seat. The truck was driven by an adult male.
All the survivors were taken to a hospital as a precaution.
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subset: commoncrawl


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Text Size:
A to Z: Back to school
POSTED: 8:17 AM May 24 2011 UPDATED: 7:35 AM Sep 01 2015
Make sure your child is ready to head back to class. Here are 26 items your student will likely need on a back-to-school shopping list.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use, which are located at the bottom of this page.


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First socio-economic survey of transgenders begins
Top Stories
- National Herald case: HC dismisses pleas of Sonia, Rahul Gandhi against summons; Cong to move SC
- India maul South Africa by 337 runs at Kotla, seal series 3-0
- Mumbai: One killed in massive slum fire in Kandivili
- Powerful earthquake jolts Tajikistan, tremors felt in Srinagar, NCR
- India-Pakistan talks: Good but not breaking news -- yet
"If you fall sick where do you go?
Have you ever been harassed
What do you identify yourself as?"
These are some of the questions that members of the NGO Samapathik Trust have been asking as they go about conducting the first socio-economic survey of the transgender community of the state. Though the transgender community is said to constitute 0.3 per cent of the general population, the absence of empirical data and scientific analysis of any data has led to a lack of awareness about the community and its needs among planners.
Bindumadhav Khire, the president of the trust, said that the idea for the survey came to the trust after the inclusion of the transgender community in the draft women's policy of the state. "There is very little data available for the community. Also, for the state, when it comes to the details of the community in terms of work, finances health facilities available etc there has been hardly any study done," he said. The trust took on the initiative to conduct this survey, as it feels it can be invaluable to the state government in formulating policies for the community.
The survey will require members of the trust to interact with the transgender community and it will be targeting the various fairs which see many transgender people coming together. "The religious fairs allows the transgender communities coming together and we hit upon it as the best opportunity to interact with them. Incidentally, all the fairs which see such congregation happen in a span of three to four months starting from December," he said.
"The questionnaire we have drawn up has been approved by anthropologist Dr Hemant Apte and covers various facets of the socio-economic life of the community," he said. Other than inquiring about their identity, the questionnaire also tries to probe into details such as how they dress up both in the privacy of their homes and in public, about their marital status, whether they have access to banks etc.
... contd.
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- Constitutional settlements requires statesmanship and generosity missing in Nepal today
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- Margi Sathi helped recreate Kutiyattam and Nangiarkoothu for a new audience
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- Paris climate summit underlines progress depends on innovation and global partnership


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Separate names with a comma.
Can anyone tell me how to merge cells in numbers? I have text in one cell and want to merge into next cell.
Second if I can ask another....
how can i mark cells and rows on ios? for some reason i just cant find that option?
How do I sort a group of cells (not the entire spreadsheet) in Numbers?
For example: I want to sort the data based on entries in column 2 but...
I need to be able to hide cells in numbers on my iPad. My searching has shown that this cannot be done. Hiding cells is mandatory for...
As a complete novice on the iPad and numbers :) is there any way to select multiple cells that are not next to each other ,e.g. A3 and D3 -
...trying to find an excel editor that respects 'locked' or 'protected' cells. Right now I've got Office2 HD and found the hard way that it does...
Can't seem to figure it out. Anybody know if it's possible? It's the latest version of Numbers and on iPad 2.
...In the application, Apple also says that it wants to make battery cells smaller in order to use the space inside portable devices more...
I know I am not a technical person...
I want to copy some of the movies I already own. I do not have many.
I have a new iPad3.
I also have an...
App Store - TI Mobile(Tactical Intervention)_PLUS
mergence cells
Is possible to mergence two or more cells? It would be strange if not...
How are you selecting the cells? It worked when I select the cells. Are you typing in the cell references?
Will do, yes solar cells would be great thanks.
Hi all!
I need:
4 solar cells
4 optical systems.
4 launch pannel (or whatever the english name is..)
I can gift solar cells
Human brain cells, the internet and the universe have similar network structures.
ahhh, that makes sense!! so much to remember, so few brain cells!!
the ipad is great. you dont need that many brain cells. and Welcome !
Is it possible to transpose an array of cells when using Numbers for iPad?
I need to enlarge a couple of cells in numbers and don't know how. Please advise
Ow to select cells in doc to go. Anybody help please
These solar cells will save a lot of money
They say if you use too much Ipad. Your brains cells get damaged? is this true?
How do you copy cells to clipboard using iPad Numbers ?
thank you for your help
*OUCH* Its ok I dont have many brain cells left, but can you see a mark??
hi all! I am in the quest too! also built one observatory. Can gift solar cells.
...experience hair fall, here's why :
The cancer drugs attack cells that undergo rapid mitosis (cell division), the cancer cells, but, even our...
Nothing wrong with jackass to kill a few hours and a few brain cells. But I think I have said it before, when I hear that lot off The Only Way Is...
That did the trick. I deleted the last (empty) column and all went perfect. Thank you so much for your help.
There appear to be some merged cells at the far right.
When sorting the entire table is re-arainged based on the chosen column. The merged...
I've damaged so many brain cells in other ways that I doubt I'll notice any difference!
Hello, I m using I-spreadsheet but I can not add or less between cells. Can any one help me.
Every time I hear Stacey Solomon' voice I can feel brain cells dying.
Sent from my iPad 2 using iPF
Interesting. I didn't know (or forgot) you could add images to cells in Numbers.
Thanks for the update.
Thank you, it's just some very basic formulas like adding cells together. I am leaning towards Numbers...
Dyslexia and ancient brain cells.
A bad combination.
Thank you for the correction.
Sent from my iPhone using iPF
Also to note Office2 hd is the only excel spreadsheet app i found that allows for merged cells.
I am unable to copy and paste to multiple cells by column to other applications all of a sudden. Single cells and multiple cells in rows copy and...
just sent you a request. Do have the solar pannels
I've upgraded and can now gift solar cells. I've moved my training centre to the residential side as I'm running out of room!


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I'm developing an app based on Grails and Vaadin 7. I managed to make them work with SpringSecurity for authentication and authorization, but I had to develop my own Service that calls the Spring Security authentication manager to make it work with Vaadin:
class SecurityService {
static transactional = true
def springSecurityService
def authenticationManager
void signIn(String username, String password) {
try {
def authentication = new UsernamePasswordAuthenticationToken(username, password)
SCH.context.authentication = authenticationManager.authenticate(authentication)
} catch (BadCredentialsException e) {
throw new SecurityException("Invalid username/password")
The problem is that now I need to implement a
remember me authentication and I don't know from where to start.
How do I make the
authenticationManager know that I want it to use
remeberMeAuthentication? I can get a boolean value from a checkbox on the login View, but what do I do with it next?


text:
Uni-Lock 2-3/8 Table Base - Springfield
This item is found in the following Product Families
Uni-Lock Table Base (Springfield Marine)
High strength black plastic base works with any 2-3/8" Uni-Lock table post. 5-3/4" Hole pattern.
- 2-3/8″ Table Base
- High-Strength Black Plastic
- 7″ Diameter With 5-3/4″ Hole Pattern
- Works With Any 2-3/8″ Uni-Lock Table Post (Sold Separately)
- 5 year warranty
Do you have one of these designed for a slightly smaller hole in the floor?
3660207 and 3660004-SM are ones that do not require going below the deck. So those are options you can look at.
This product ships in 1 business day.
Add to Cart and enter your Postal Code to determine the shipping charges and estimated delivery date.
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text:
Présentation de l'éditeur
Want a DIRECT EXPERIENCE of Reality Beyond the Physical?
Many call out-of-body (OBE) experiences "astral projections" because of the unusual perceptive nature of these experiences. But there's more than metaphysics involved in OBE. Serious scientists are interested in this phenomena, and it has been studied by both the USA and Russia. The book provides proven step-by-step methods to help you safely expand YOUR conscious awareness beyond the limits of your physical self. One thing is certain -- exploring out-of-body reality opens you to an exciting new way tap into your higher levels of consciousness and true inner potential.
"A great guide to direct experience of higher levels of consciousness."
"Best book I've read on OBE's. Has exercises that read like a pilot's instruction manual.
"I am not a casual book reviewer. Actually, I am often VERY critical. So when I tell you this book is exceptional, you can understand this is an independent analysis by a professional reviewer (I post exactly the truth about each book I review)."
"I admit I was skeptical. I tried the authors 'familiar location' method and to my total shock had two OBEs on the first night. My conclusion: this book is the best ever way to start on this adventure!"
Dr. Jill Ammon-Wexler is a 45-year pioneer brain/mind and consciousness researcher and doctor of psychology. She has concluded from both personal experience and the reports of her clients over the years that we CAN (and do) in fact project our consciousness far out beyond the limits of our physical self.


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The Pride of Canada Carousel, a one-of-a-kind merry-go-round featuring 44 rideable sculptures was unveiled at a private preview event on Tuesday June 28, 2016 in Downtown Markham before making its public debut at a free Canada Day celebration.
Read The Markham Board of Trade's profile on Remington Group patriarch and CEO Rudy Bratty, featured as the cover story of this quarter's business magazine, The VOICE. Mr. Bratty discusses his road to success and his vision behind Downtown Markham.
The next big thing in Downtown Markham is here! York Condos is Downtown Markham's next phase of condominiums just steps to York University's new campus and now open to the public. Register now.


text:
Results 61 — 70
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Corporate Development and Marketing Internship
STEMconnector — Washington, DC
February 05 2016
Internship Overview Are you passionate about the future of our country and the future of our workforce? Do you want to join a team of dynamic professionals that share your passion? Do you want to be a…
Application Deadline: Available Year-round
Wildlife Rehabilitation Intern
South Sound Critter Care — Kent, WA
February 04 2016
This is an opportunity to learn how to rear birds and mammals successfully from hatch or birth to release. For someone with an interest in wild animals this internship will show you a window into wild…
Application Deadline: Available Year-round
NOW HIRING - Entry Level
DBC inc — Troy, MI
February 04 2016
DBC inc, Detroits premier sales and marketing firm, is now looking for superior entry level reps to assist with their business development efforts. We are looking for those professional and committed …
Application Deadline: Available Year-round
Silicon Valley Leadership Group — San Jose, CA
February 02 2016
Want to experience first hand how public policy is developed on local, state, and federal levels? Want to make a difference in areas such as improving middle school math education, reducing greenhouse…
Application Deadline: Available Year-round
Community Organizing Intern
Clean Water Action — Philadelphia, PA
January 29 2016
DESCRIPTION: Get a behind the scenes look into a grassroots environmental campaign as one of our paid community organizing interns. Learn how policies are affected from the ground up, through constitu…
Application Deadline: Available Year-round
Non-Profit Management Intern with Student Union
MakerState — Virtual
January 28 2016
We are a successful and fast-growing NYC-based STEM education program that is currently accepting internship applications for a central non-profit management role in helping grow our non-profit sister…
Application Deadline: Available Year-round
Communications Intern (Spring/Summer 2016)
VICA — Van Nuys, CA
January 25 2016
The Valley Industry & Commerce Association (VICA) is recognized as the top business advocacy organization in the San Fernando Valley for its outreach to local, state and federal officials. VICA is a S…
Application Deadline: Available Year-round
Event Planning Internship for National Leadership Diversity Conference 2016 in Atlanta
NAMCO National Association of Minority Companies Inc. — Virtual
January 12 2016
Dear Internship Candidate! We are nearing the historic 2016 National Leadership Diversity Summit and we want you to help make the event a success! This year's theme is "Atlanta Gateway to Opportunity …
Application Deadline: Available Year-round
Advocacy Internship
Alzheimer's Association, MA/NH Chapter — Watertown, MA
January 10 2016
Overview of Alzheimers Association Founded in 1980, the mission of the Alzheimers Association, Massachusetts/New Hampshire Chapter is to eliminate Alzheimers disease through the advancement of researc…
Application Deadline: Available Year-round
Event Planning Internship
Miramar Pembroke Pines Regional Chamber of Commerce — Pembroke Pines, FL
January 09 2016
The Miramar Pembroke Pines Regional Chamber (MPPRCC) is recruiting interns to support the organization in its marketing efforts. This internship program offers the opportunity to work with a group of …
Application Deadline: Available Year-round


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who wow, I would never have guessed "water" :) It looks so much like the sky, even with the white "cloud" :)) How are things up there? Did Kate and William pay you a visit? LA will get them in a day or two.:) They seem to be enjoying their visit on this side of the pond.
:D The cloud is the sun's reflection in the water. It seems they don't like Vancouver. Maybe they were put off by the hockey riots!
Cheers, Mrs. O and Tery.
This is Master peace!
Really love one!
Wow Whoe!
Very nice
LIKED-14! Beautiful photo!
Greetings from Ukraine, Yuri.
Thanks very much, Mohammad, Sandy, Yuri and Marion. :)
Beautiful macro and flower
► Best regards
► Seyit
tooooooo beautiful. the water in the background is very deceiving!
And yellow to you too. This must have been a hell of a difficult lighting condition for this shot. Well done!
گل زنبق زیبا ست ... I Like
Best wishes from IRAN
... Barát
Big LIKE, nice capture, Interesting composition
Regards from Beirut, Lebanon; Ali
Pretty snazzy.
Yep! very yellow but very pretty :) Best wishes, Anita
really fine macro who
Cheers, Seyit, Joe, Caroline, Caroline, Tibor, Barát, Ali, Guy, Anita and Larry. :D
Congratulations for this splendid shot! Best regards from Germany, Stefan L
Photo taken in Vancouver, BC, Canada


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|This image or media is now in the public domain in Thailand because its term of copyright has expired. According to Chapter 1, Sections 2-4 of Copyright Act, BE 2537 (1994) (translation), work which meets one of the following conditions is in the public domain:
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Access your Emirates Skywards or Emirates Business Rewards account
Explore our website in multiple languages for a tailored experience.
Find flights, see our featured fares and earn Skywards Miles on your travels.
Find the best fares across our global network.
Check in online, choose your seats and add extra services with one click.
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Transports the first Mercedes-Benz C 63 AMG Coupe Black Series to arrive in Australia
DUBAI, U.A.E., 5th March 2012: Emirates SkyCargo, the freight division of Emirates, one of the fastest growing international airlines, has delivered Australia's first Mercedes-Benz C 63 AMG Coupe Black Series car.
Direct from Frankfurt via one convenient stop in Dubai onboard the newly introduced dedicated weekly freighter service, the vehicle was transported to Australia to perform a number of special duties during the 2012 Australian Formula Grand Prix.
Emirates' Cargo Manager Australia, Greg Johnson, said he was honoured Mercedes-Benz chose to entrust Emirates SkyCargo to carry the AUD$245,000 vehicle – the first of 32 coming to Australia - and has no doubt a reputation for excellence in every area of operation played a part.
"While we have the capacity to transport 103 tonnes of cargo a week on the new Boeing 777 Freighter, we take pride in making sure each and every customer receives the attention to detail they require," Mr Johnson said.
"Moving the high-value Mercedes-Benz C 63 AMG Coupe Black Series required sophisticated equipment and specialist handling to ensure it was race-ready once it hit the tarmac in Australia."
"Across our seamless network between Europe, Dubai and Australia, Emirates staff are well trained and highly experienced in dealing with high-value consignments, ensuring this very special car enjoyed a smooth ride," he added.
The Boeing 777 Freighter features include a wide main deck cargo door, making it ideal for uplifting oversized shipments like the Mercedes-Benz C 63 AMG Coupe Black Series.
This weekly dedicated freighter service was first operated to Australia in September 2011, and boosts Emirates SkyCargo's import capacity to 1370 tonnes per week.
With long-range flying capacity and technologically advanced General Electric engines, the Boeing 777F provides piece of mind for transporters of precious cargo, while maintaining the lowest fuel burn of any comparably-sized aircraft.
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text:
Dr. Clauw has received consulting fees, speaking fees, and/or honoraria from Pfizer, Forest Laboratories, Eli Lilly, Pierre Fabre, Cypress Biosciences, Wyeth, UCB, AstraZeneca, Merck, Johnson & Johnson, Nuvo, Jazz, Abbott, and Cerephex (more than $10,000 each) and has received research grants from Forest Laboratories, Pfizer, Cerephex, and Nuvo.
Prevalence of the Fibromyalgia Phenotype in Patients With Spine Pain Presenting to a Tertiary Care Pain Clinic and the Potential Treatment Implications†
Version of Record online: 27 NOV 2013
DOI: 10.1002/art.38178
Copyright © 2013 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 65, Issue 12, pages 3285–3292, December 2013
Additional Information
How to Cite
Brummett, C. M., Goesling, J., Tsodikov, A., Meraj, T. S., Wasserman, R. A., Clauw, D. J. and Hassett, A. L. (2013), Prevalence of the Fibromyalgia Phenotype in Patients With Spine Pain Presenting to a Tertiary Care Pain Clinic and the Potential Treatment Implications. Arthritis & Rheumatism, 65: 3285–3292. doi: 10.1002/art.38178
- †
Preliminary data presented in the Best Abstracts session at the American Society of Anesthesiologists Annual Meeting, Chicago, IL, October 2011.
Publication History
- Issue online: 27 NOV 2013
- Version of Record online: 27 NOV 2013
- Accepted manuscript online: 10 SEP 2013 03:34PM EST
- Manuscript Accepted: 27 AUG 2013
- Manuscript Received: 29 APR 2013
Funded by
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases). Grant Number: R01-AR-060392
- American Society of Regional Anesthesia and Pain Medicine (Chronic Pain Research)
- University of Michigan, Department of Anesthesiology
- Abstract
- Article
- References
- Cited By
- Top of page
- Abstract
- Acknowledgments
Injections for spinal pain have high failure rates, emphasizing the importance of patient selection. It is possible that detecting the presence of a fibromyalgia (FM)–like phenotype could aid in prediction, because in these individuals a peripheral injection would not address pain due to alterations in central neurotransmission. We undertook this study to test the hypothesis that patients who have spine pain meeting survey criteria for FM would be phenotypically distinct from those who do not.
We studied 548 patients diagnosed as having primary spine pain. All patients completed validated self-report questionnaires, including the Brief Pain Inventory, the PainDETECT questionnaire, the Hospital Anxiety and Depression Scale, measures of physical function, and the FM criteria and severity scales.
Forty-two percent of the patients were FM positive according to the FM criteria and severity scales. Compared with FM-negative patients, FM-positive patients were more likely to be younger, unemployed, and receiving compensation for pain and to have greater pain severity and pain interference and more neuropathic pain descriptors as well as higher levels of depression and anxiety and a lower level of physical function (P < 0.002 for each comparison). Female sex, neuropathic pain, pain interference, and anxiety were independently predictive of FM status in a multivariate analysis (P < 0.01 for all variables). Receiver operating characteristic curve analysis showed a strength of association of 0.80 as measured by the cross-validated C statistic.
Using the FM criteria and severity scales, we demonstrated profound phenotypic differences in a population of patients with spine pain. Although centralized pain cannot be confirmed with a self-report instrument alone, the pathophysiology of FM may help explain a portion of the variability of responses to spine interventions.
Spine pain is one of the most common causes of disability in the world. It is estimated that 10–15% of the US population seeks care for low back pain each year ([1]). Second only to the treatment of joint pain, spine pain is considered the most expensive musculoskeletal condition; estimates exceed $140 billion in annual lost wages and treatment costs ([1, 2]). Recently, there has been an explosion in the use of minimally invasive therapies for the treatment of spine pain. Between 1997 and 2006 in the Medicare population, facet joint interventions increased by 543% ([3]), and epidural steroid injections increased by 102% ([4]). These and other minimally invasive therapies have high failure rates, implying that patient selection may play a crucial role ([5, 6]).
Some patient risk factors predictive of poor outcomes from epidural steroid injections and facet joint interventions include long duration of pain, opioid consumption, previous spine surgery, younger age, increased pain sensitivity, depression, and anxiety ([5, 7-12]). Similarly, pain in other locations, depression, catastrophizing, and somatization all have been described as predictors of lesser analgesic response from lower extremity joint arthroplasty ([13]). It is possible that this collection of patient risk factors can be explained by a common pathophysiologic mechanism. There is a growing appreciation of the importance of augmented central nervous system (CNS) processing of pain and other symptoms in several chronic pain states ([14]). Such states lack clear peripheral pathology and have been given specific names, including fibromyalgia (FM), irritable bowel syndrome, and interstitial cystitis ([14-17]). Arguably the best studied of these, FM, is characterized by widespread body pain and comorbid symptoms (e.g., fatigue, trouble thinking, depression) without apparent peripheral pathology. Instead, pain sensitivity and neuropathic pain symptoms have been associated with alterations in central neurotransmission ([15, 18-22]).
Experimental pain testing and functional neuroimaging studies have shown that subsets of individuals with classically described "peripheral" pain conditions, such as osteoarthritis and rheumatoid arthritis, demonstrate patterns of augmented CNS pain processing similar to those seen in conditions like FM, and thus potentially have a component of "centralized pain" ([23, 24]). The few experimental studies conducted in spine pain support the same conclusion. Pain threshold has been shown to be a robust predictor of pain response and physical function ([25]), and functional magnetic resonance imaging in low back pain has demonstrated patterns of augmented central pain processing similar to those seen with FM ([26]). However, the frequency of "centralized pain" in a population of patients with spine pain is not known.
In 2011, FM criteria and severity scales (also known as survey criteria for FM) were introduced for use in clinical and epidemiologic studies ([27]). The FM criteria and severity scales rely on the completion of a self-report questionnaire and, like the American College of Rheumatology (ACR) preliminary diagnostic criteria introduced in 2010 ([28]), do not require a tender point examination ([27]). The aim of the present study was to determine whether the FM criteria and severity scales could differentiate patients with spine pain in terms of measures of pain, affect, and function. FM is rarely diagnosed in this population, and patients are generally treated as having pain that is predominantly or solely due to peripheral pathology of the spine. We hypothesized that patients characterized as FM positive according to the FM criteria and severity scales ([27-29]), which were used as a surrogate of centralized pain in this study, would report pain that is more neuropathic in nature and would have higher levels of pain, depression, anxiety, and disability than those not meeting FM criteria. The clinical implications of this would be that a brief self-report measure (e.g., the FM criteria and severity scales) could eventually be used to guide patient selection for various interventions based in part on underlying pain mechanisms.
- Top of page
- Abstract
- Acknowledgments
Approval was obtained from the Institutional Review Board of the University of Michigan, Ann Arbor. We included new patients (age ≥18 years) presenting to the University of Michigan Back and Pain Center (Department of Anesthesiology) from November 2010 to March 2012. As previously described ([30]), all new patients presenting for treatment at our academic outpatient pain clinic complete an intake packet that includes validated self-report measures of pain, psychological status, physical function, and demographic information (including age, sex, race, ethnicity, marital status, employment status, and compensation for pain, as reported by the patient from a predefined list). A coversheet for the intake packet explains that the information will be used for clinical care and research, and a waiver of written informed consent was obtained from the Institutional Review Board. The International Classification of Diseases, Ninth Revision (ICD-9) code assigned by the treating physician was used to define the spine pain cohort. Disorders of the axial neck, middle and low back, or surrounding spine structures, as well as radicular pain and results of failed spine surgery, were all included (Table 1). A 3-month audit of the number of new patients evaluated, with phenotyping included in the data set, demonstrated that data were captured for 85.7% of the patients (data not shown).
|Location, diagnosis
|ICD-9 code
|Neck and upper extremities
|Cervicalgia, neck
|Facet arthropathy cervical or spondylosis without myelopathy cervical
|Degenerative disc cervical
|Radiculopathy cervical or cervical-radiculitis/neck
|Spondylosis with myelopathy cervical
|Postlaminectomy syndrome cervical
|Spinal stenosis cervical
|Middle back
|Thoracic spine–middle back
|Herniated nucleus pulposus–thoracic
|Low back and lower extremities
|Low back/lumbago
|Degenerative disc lumbar
|Facet arthropathy lumbar or spondylosis without myelopathy lumbosacral
|Herniated nucleus pulposus lumbar
|Radiculopathy thoracic/lumbar
|Spinal stenosis lumbar
|Postlaminectomy syndrome lumbar
|Sacroiliac joint dysfunction
Instruments used to evaluate patients
The FM criteria and severity scales consist of an assessment of widespread pain and symptom severity ([27, 28]). The Widespread Pain Index (WPI) was calculated using the Michigan Body Map ([31]) to assess the 19 specific body areas described in the FM criteria and severity scales (score 0–19). Symptom severity was evaluated using the Symptom Severity (SS) scale (score 0–12). As per the FM survey criteria, patients were classified as FM positive if their scores were WPI ≥7 and SS ≥5 or WPI 3–6 and SS ≥9. The validity of the FM criteria and severity scales has been established, both when compared with the 1990 ACR classification criteria (which include the tender point examination) ([29, 32]) and when compared with the 2010 ACR preliminary diagnostic criteria (which include physician's assessment) ([28, 33]). Patients missing FM criteria and severity scales data were excluded from analysis. Additional phenotyping measures were completed/recorded, including the Brief Pain Inventory (BPI) (pain intensity and interference) ([34]), the PainDETECT questionnaire (neuropathic pain) ([35]), the Oswestry Disability Index (ODI) (physical function) ([36]), the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function Short Form 1 (physical function) ([37]), the Hospital Anxiety and Depression Scale (HADS) (symptoms of depression and anxiety) ([38]), and the duration of pain.
Statistical analysis
Data were entered into the Assessment of Pain Outcomes Longitudinal Electronic Data Capture system ([30]). Missing data for the validated instruments were handled as described by authors of the instruments ([35, 38, 39]). As noted above, patients who did not complete all the components of the FM criteria and severity scales were not included in the analysis. Additionally, patients missing more than 1 item on the BPI subscales, PainDETECT questionnaire, and ODI were excluded. The PROMIS Physical Function Short Form 1 requires complete data on all 10 items, so patients missing any items were excluded. For the HADS, when 6 of the 7 questions were answered, a single value for the missing item was inferred by imputation of the mean of the other 6 values as recommended. For the other instruments, only 1 missing question was allowed; however, other completed questionnaires were allowed (i.e., patients were not completely excluded from the analysis for having 1 incomplete questionnaire).
Data were analyzed using R software, version 2.15.0 (www.r-project.org) and SPSS software, version 19. Between-group comparisons were performed using a t-test for continuous variables, a chi-square test for binary variables, and a Wilcoxon test for ordered categorical variables. The significance level was set at 0.025 to account for the previous analysis on a smaller data set conducted for the presented abstract. We studied patterns of association between the observed phenotype, and their relationship with the centralized pain phenotype, using binary categorization of FM status by the previously described FM criteria and severity scales (FM positive versus FM negative) ([27, 28]) and the continuous "fibromyalgia-ness" score (the sum of the WPI and SS scales). Multivariate linear regression was used to study association between the continuous FM score and measured phenotype and pain variables. Association of the phenotype and pain variable panel with the binary FM status was analyzed using logistic regression. Best model selection using Akaike's information criterion (AIC) and likelihood ratio tests was used to select the best set of predictor variables. Prediction strength of the logistic model was analyzed using a receiver operating characteristic (ROC) curve. The ROC curve analysis was cross-validated (10-fold) to ensure reproducibility of predictions and avoid model overfitting. Cross-validated estimate of the area under the ROC curve (C statistic) was used to characterize the predictive performance of the phenotype and pain profile with respect to the FM categorization (FM positive or FM negative). Model adequacy was tested using a variety of standardized residual plots (not shown).
Radicular pain and spinal stenosis are frequently associated with neuropathic pain symptoms and are often differentiated from axial spine pain. In order to specifically analyze the portion of the cohort with axial spine pain (neck pain, middle back pain, and low back pain), the multivariate analyses noted above were repeated after excluding patients with radicular or non–axial spine pain disorders (excluded ICD-9 codes 723.4 [cervical radiculopathy], 721.1 [cervical spondylosis], 722.81 [postlaminectomy syndrome cervical], 723 [cervical spinal stenosis], 722.11 [thoracic herniated nucleus pulposus], 722.1 [lumbar herniated nucleus pulposus], 724.4 [thoracic or lumbar radiculopathy], 724.02 [lumbar spinal stenosis], 722.83 [lumbar postlaminectomy syndrome], 739.4 [sacroiliac joint dysfunction], 720.2 [sacroiliitis]; total n = 130) (Table 1).
- Top of page
- Abstract
- Acknowledgments
A total of 1,208 new patients were seen in the pain clinic over the defined time period, with diagnoses of primary spine pain in 548 patients. After exclusion of patients who did not have complete data for the FM criteria and severity scales, 443 patients were retained for the analysis (Table 2). Of these patients, 186 (42%) were FM positive according to the FM criteria and severity scales. In univariate analyses, FM-positive patients were younger (P = 0.001), less likely to be employed (P = 0.0005), and more likely to be receiving compensation for their pain (P = 0.0005), but there were no other significant differences between the 2 groups with respect to demographic variables (Table 2). Compared to FM-negative patients, FM-positive patients were more likely to have pain of a longer duration (P = 0.0096) and had higher scores on measures of pain severity, pain interference, and neuropathic pain (P < 0.0001). FM-positive patients also reported lower physical function and showed higher levels of anxiety and more symptoms of depression (P < 0.0001).
|FM-negative (n = 257)
|FM-positive (n = 186)
|FM criteria and severity scales score
|8.46 ± 2.79
|17.2 ± 3.89
|Age, years
|51.9 ± 17.5
|46.9 ± 13.6
|Female, %
|Caucasian, %
|College education, %
|Married, %
|Employed, %
|Receiving compensation for pain, %
|Type of compensation, %
|Social security
|Long-term disability
|Workers' compensation
|Sick leave
|No-fault insurance
|Pain phenotype
|Pain severity (BPI)
|6.02 ± 1.83
|7.2 ± 1.54
|Pain interference (BPI)
|6.33 ± 2.11
|7.95 ± 1.69
|Neuropathic pain descriptors (PainDETECT questionnaire)
|14 ± 7.85
|22.1 ± 7.79
|Physical function (ODI)
|40.3 ± 16.6
|55.3 ± 15.8
|Physical function (PROMIS Physical Function Short Form 1)
|31.9 ± 7.42
|26.9 ± 7.81
|Anxiety (HADS)
|6.61 ± 3.67
|11.7 ± 4.65
|Depression (HADS)
|7.15 ± 4.23
|11.5 ± 4.4
|Duration of pain, %
|<3 months
|3–6 months
|7–12 months
|1–5 years
|>5 years
The multivariate analyses of the associations between the observed demographic and pain/mood/function phenotype and both the continuous FM score and the binary FM classification are shown in Table 3. FM status (positive versus negative) could be best predicted using neuropathic pain (the PainDETECT questionnaire), physical function (the ODI), anxiety (the HADS), and compensation for pain, with a high area under the ROC curve (C statistic, area under the curve [AUC] = 0.80). The best model search using AIC resulted in the same model as the cross-validated ROC curve analysis (Figure 1). Multivariate prediction of the FM score as a continuous score reported a similar set of highly significant best model predictors: sex (male versus female), pain interference (the BPI), neuropathic pain, and anxiety (P < 0.005 for each significant predictor) (Table 3).
|Model, predictor variable
|Sex (male vs. female)
|Physical function (ODI)
|Pain interference (BPI)
|Neuropathic pain (PainDETECT questionnaire)
|Anxiety (HADS)
|Neuropathic pain (PainDETECT questionnaire)
|Physical function (ODI)
|Anxiety (HADS)
|Compensation for pain
A subanalysis of the portion of the cohort with axial spine pain was conducted, which resulted in a reduction in the number of patients (n = 418) available for the analysis (see statistical analysis section in Patients and Methods for additional details). Descriptive between- group analysis in the subset of patients with axial spine pain yielded an outcome very similar to that shown in Table 1 (not shown). The smaller sample size resulted in a reduced panel of pain and phenotype variables in the trimmed multivariate models. Pain interference, neuropathic pain, and anxiety were the best predictors after variable selection using linear (continuous FM status) and logistic (binary FM status) models (P < 0.001 for all variables). The analysis yielded almost the same AUC (C statistic) of 0.81 (not shown).
- Top of page
- Abstract
- Acknowledgments
We found that 42% of the patients presenting to a tertiary care facility with a primary diagnosis of spine pain had FM according to the FM criteria and severity scales, which suggests the presence of centralized pain. To our knowledge, this is the first time that the FM criteria and severity scales have been used to differentiate a spine pain cohort. FM-positive patients reported a strikingly different pain phenotype from FM-negative patients (i.e., in univariate analyses the former were more likely to be female, younger, unemployed, receiving compensation for their pain, reporting greater pain intensity and interference, anxious, depressed, using neuropathic pain descriptors, and reporting diminished functioning) (Table 2). Analyzing the groups using the FM criteria and severity scales score as a dichotomous (logistic) or continuous (linear) measure further demonstrated that neuropathic pain descriptors, anxiety, pain interference, and physical function were independently predictive of the FM criteria and severity scales score (Table 3), which is consistent with what has previously been described in patients diagnosed as having FM using the 1990 ACR classification criteria ([32]). The independent predictors from the multivariate models are some of the most commonly described predictors of poor outcomes in minimally invasive spine interventions and postsurgical pain. Hence, there may be a common underlying pathophysiology or "diagnosis" driving these findings.
The diagnosis of FM has been a point of controversy for years in the community of pain specialists, as there is no definitive diagnostic test. FM positivity according to the FM criteria and severity scales does not confirm categorical diagnosis. Instead, according to the 2012 Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome (http://www.canadianpainsociety.ca/pdf/Fibromyalgia_Guidelines_2012.pdf), the taking of a history, a physical examination, and laboratory testing (e.g., blood count, erythrocyte sedimentation rate, C-reactive protein, creatine kinase, and thyroid-stimulating hormone) by an experienced provider are required to make the diagnosis of FM. However, comorbid FM is common in nearly all other musculoskeletal chronic pain conditions, including osteoarthritis and rheumatoid arthritis (estimates range from 20% to 30%) ([23, 24]). The validity of the FM criteria and severity scales has been established, both when compared with the 1990 ACR classification criteria (which include the tender point examination) ([29, 32]) and when compared with the 2010 ACR preliminary diagnostic criteria (which include physician's assessment) ([28, 33]). As was previously recommended, the present study applied this validated self-report measure in an epidemiologic manner to detect widespread body pain and comorbid symptoms.
These data and those from experimental studies ([26, 40, 41]) suggest that centralized pain may be very common in spine pain. For example, 2 studies have shown that a sizable proportion of individuals with chronic low back pain display diffuse tenderness (e.g., mechanical hyperalgesia) and have functional magnetic resonance imaging findings consistent with FM or similar centralized pain states ([25, 26]). Using the 4-quadrant pain described in the 1990 ACR classification criteria for FM, a retrospective study showed that female patients with higher pain severity, a family history of chronic widespread pain, and more painful comorbidities were more likely to transition from neck and back pain to chronic widespread pain ([42]). In the present study, independent predictors of FM positivity according to the FM criteria and severity scales included female sex, higher levels of neuropathic pain descriptors, anxiety, more pain interference, and lower levels of physical function (Table 3). Neuropathic pain descriptors in particular are thought to be strongly associated with the FM pain phenotype and have been shown to correlate with the number of tender points and pain sensitivity during experimental pain testing ([20, 21]). Because radicular pain would be expected to present with more neuropathic pain symptoms, the analyses were also repeated after excluding radicular pain and non–axial spine pain diagnoses, and the results did not change.
Most axial spine pain diagnoses (e.g., facet arthropathy, lumbago) are not normally thought to be associated with high levels of neuropathic pain, yet among FM-positive patients according to the FM criteria and severity scales, the mean value for the PainDETECT measure exceeded the instrument's defined cut point for neuropathic pain—with or without including patients with radicular pain diagnoses ([35]). Although patients in different diagnostic groups who meet the criteria for neuropathic pain using the PainDETECT questionnaire certainly describe similar levels of pain, the phenotype of FM-positive patients according to the FM criteria and severity scales is distinct.
The finding that many patients with spine pain report widespread body pain and comorbid symptoms, such as fatigue, trouble thinking, anxiety, and/or depression, could have important treatment implications and may explain a portion of the high failure rates described for some of the most common spine interventions. Injections and peripherally targeted analgesics would be expected to provide less benefit in a patient with altered central pain processing than in those with predominantly peripheral pathology. FM is associated with lower levels of neurotransmitters that inhibit pain, including norepinephrine, serotonin, and γ-aminobutyric acid, along with higher levels of neurotransmitters that increase pain, including glutamate ([15, 43]). FM patients also have lower endogenous opioid receptor binding availability and high levels of cerebrospinal fluid opioids ([44]), together suggesting that the endogenous opioid system is already activated in FM and thus perhaps explaining the anecdotal experience that opioids are ineffective in most of these patients ([45]).
The use of minimally invasive interventions for spine pain, such as epidural steroid injections and facet joint interventions, has increased dramatically in recent years ([3]). A recent well-publicized meta-analysis has called into question the long-term efficacy of epidural steroid injections ([46]), and studies of response prediction estimate rates of treatment failure to be between 25% and 45% ([47-49]). Similarly, although the efficacy of facet joint interventions has been established in tightly selected patient populations ([50, 51]), higher failure rates (39–47%) have been shown in retrospective studies ([5, 6]), and effectiveness in standard clinical care is not known. Back and neck pain are frequently described in FM, and it is possible that the high failure rate for these interventions is in part due to intervention on a peripheral target in the spine when the nature of the patient's pain is due at least in part to brain and spinal cord dysfunction. Taken together, these data make a compelling case for the study of a modified treatment approach. For example, previous studies have demonstrated efficacy of serotonin-norepinephrine reuptake inhibitors in chronic low back pain ([52]). Nonpharmacologic interventions, such as cognitive behavioral therapy and exercise, have also demonstrated excellent effect sizes that often exceed those of pharmacologic interventions in FM and other pain states ([53]).
This study was conducted at a single large, tertiary care pain clinic, and these results may not be generalizable. The present study is largely hypothesis generating as it is cross-sectional in nature. Despite the profound phenotypic differences demonstrated, additional research is needed to evaluate the presence of centralized pain (e.g., quantitative sensory testing, neuroimaging) and then to better understand the impact of centralized pain on treatment outcomes. Prospective studies are required to examine whether some of the outcome measures used herein are better than a detailed history and physical examination and review of radiographic findings at predicting which patients with axial pain will respond best to peripherally directed procedures, regardless of "diagnosis" (e.g., lumbago, facet joint arthropathy). As with any data set, this study was limited by the variables included in the patient-completed phenotype assessment.
New patients presenting to a tertiary care pain clinic with a diagnosis of primary spine pain are commonly determined to have FM according to the FM criteria and severity scales, indicating that more widespread pain is present along with a constellation of associated symptoms that are presumed to be largely due to alterations in central neurotransmission. In the present study, patients with spine pain who were FM positive according to the FM criteria and severity scales described profound phenotypic differences from those who were FM negative, including more neuropathic pain descriptors, higher levels of anxiety symptoms, greater pain interference, and lower physical functioning. These factors largely overlap with those found to be predictive of poor outcomes in spine pain interventions. It is possible that a simple self-report measure could aid in the prediction of outcomes of some of the most common minimally invasive spine interventions.
- Top of page
- Abstract
- Acknowledgments
All authors were involved in drafting the article or revising it critically for important intellectual content, and all authors approved the final version to be published. Dr. Brummett had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study conception and design. Brummett, Goesling, Tsodikov, Meraj, Wasserman, Clauw, Hassett.
Acquisition of data. Brummett, Goesling, Meraj, Wasserman, Hassett.
Analysis and interpretation of data. Brummett, Goesling, Tsodikov, Meraj, Wasserman, Clauw, Hassett.
- Top of page
- Abstract
- Acknowledgments
We thank David A. Williams, PhD (Professor, Department of Anesthesiology, University of Michigan, Ann Arbor) and Kevin K. Tremper, PhD, MD (Professor and Chairman, Department of Anesthesiology, University of Michigan, Ann Arbor) for guidance and support.
- Top of page
- Abstract
- Acknowledgments
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Welcome to Frederick Law Olmsted's Emerald Necklace
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Earlier this morning, President Obama appeared on the Rickey Smiley Morning Show and spoke about next week's Midterm Elections. He also spoke about his new love for "Neo-Soul" music, which his wife, First Lady Michelle Obama introduced him to.
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A Real Florist, for Over 50 Years | Order online for worldwide delivery
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LEMASTERS, JR.: The Chase Is Far From Over
After Jimmie Johnson retook the point lead following the Price Chopper 400 at Kansas Speedway, there was the thought that we were seeing the same movie, different season.
After Jimmie Johnson retook the point lead following the Price Chopper 400 at Kansas Speedway, there was the thought that we were seeing the same movie, different season.
Lap 155 of Sunday's Price Chopper 400 at Kansas Speedway might have been a watershed moment for David Reutimann. It was an eye-opener for Kyle Busch.
For the first two races of the Chase, Jimmie Johnson wasn't a threat, or at least wasn't the point leader. That meant that the other 11 drivers felt like the Chase was wide open instead of a 10-race chase to the inevitable.
Denny Hamlin led the points the last three weeks, and hoped to stay on top leaving Kansas. He didn't, losing 43 points to Jimmie Johnson and falling to second.
The biggest hit of the Price Chopper 400 Sunday came in turn two, and it was delivered in a righteous fever from a driver who had had enough.
Greg Biffle came on strong late in the Price Chopper 400 at Kansas Speedway on Sunday, holding off a resurgent Jimmie Johnson to earn his second victory of the season and the first for a Ford in the Chase.
Joey Logano held off teammate Kyle Busch on a late-race restart to win Saturday's Kansas Lottery 300
RICHMOND, Va.
Not too far to the north of this capital of the Confederacy, there sits a five-sided building.
Nine years ago Saturday, it was a…
RICHMOND, Va. — For such a big race, the Air Guard 400 was mainly about Denny Hamlin and Clint Bowyer.
Hamlin, the hometown kid who…
RICHMOND, Va. — Denny Hamlin spent the entire off-season answering questions about how it felt to be the favorite to end Jimmie Johnson's four-year…


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SKII Repair C
60 reviews
76% would repurchase
Package Quality: 4.3
Price: $$$$
Package Quality: 4.3
Price: $$$$
INGREDIENTSSaccharomycopsis Ferment Filtrate (Pitera), Water, Glycerin, Butylene Glycol, Pentylene Glycol, Sodium Hyaluronate, Sodium Benzoate, Methylparaben
on 6/6/2016 10:36:00 AM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Brunette, Wavy, Coarse
Eyes: Hazel
AH MA ZING! This product instantly plump my skin. I used it every night before bed after FTE and It makes my day when I wake up in the morning. I got this due to special promo from buying FTE so I paid fo only a quarter of the normal price. I won't repurchase because it's way way too expensive, though.
on 2/27/2016 9:41:00 AM
Age: 19-24
Skin: Other, Other, Not Sure
Hair: Other, Other, Other
Eyes: Other
I have combination skin with oily and acne prone T zone, and this is my go to serum.
I use it day and night after my essence and before my moisturiser / or my additional serum (yes, sometimes I use two serums in my daily routine). It's absorbed instantly without any greasiness. It hydrates and diminishes dry patches around my nose and mouth without makes my skin oilier. I use it on my eye area because I'm in the budget, and it works well too.
It doesn't irritate my skin at all. I still can use it when my skin is too sensitive due to the excessive usage of kojic acid and vitamin c (I want to lighten my dark spots and I overdue it).
This is not a miracle serum. It's just a very well-made hydrating serum and it works well on the most sensitive skin I might ever have.
To Read all 60 Reviews, Login or Join
on 9/24/2015 7:55:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Black
I have oily acne prone skin which used to look red and irritated.
I'm on my 3rd bottle and I use this every night without moisturizer, sometimes in the morning as well. My skin is now more translucent with minimal redness. Skin's texture also becomes a lot more supple and firm, and hydrated well thus less oily. As for acne, I still need acne medication but this serum really improves my overall skin look noticeably. Absorbs real fast, no funky smell.
Downside : the price, seriously though.
on 7/30/2015 5:35:00 PM
Age: 36-43
Skin: Acne-prone, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Black
I bought Repair C from Strawberrynet which obviously cheaper. During winter, I can feel my skin so dry. I apply Repair C after FTE (facial treatment essence) all over my face and top it up with Stempower. I use Repair C about 3x in a week. Take turn with other SK II essence ie. Cellumination Aura Essence. A lot of people thought Repair C is for vitamin C. Apparently C is not vitamin C. C stands for Concentrate. Hence SK II Repair C is hydration concentrate. It gives you hydration serum. I like it so much. No breakouts, not oily. Good for all skin types to apply at night time. Definitely will buy again and again.
on 7/11/2015 5:47:00 AM
Age: 25-29
Skin: Combination, Fair, Cool
Hair: Brunette, Straight, Fine
Eyes: Brown
This is my go-to product for when my skin misbehaves. Breakouts, dry patches, dull-looking skin... Repair C is the serum / treatment product I immediately reach out for.
This clear, thin and runny liquid absorbs quickly into the skin and doesn't leave any greasiness behind, making it the perfect base for layering serums on top of it (like I do!)
If I'm suffering from a bad breakout, this serum soothes the redness and helps speed up the healing process.It also banishes dry patches, something that has been affecting my nose (I suffer from sinusitis and am constantly rubbing my nose with tissue, hence the dry patches) for years. Should my skin start peeling, all I need to do is apply Repair C over it and it works overnight, leaving me with soft, bright and smooth skin.
Here comes the cheeky bit... I do not use this everyday! I only use it when my skin's in trouble, and once it goes back to normal this too goes back onto my dresser, untouched until the next skin issue surfaces. =p Despite that, I cannot see myself being without this as it works wonders on my sensitive combination / dry skin.
on 7/9/2015 11:57:00 PM
Age: 30-35
Skin: Sensitive, Fair, Neutral
Hair: Brunette, Straight, Fine
Eyes: Brown
I've always had compliment-attracting skin, and I really enjoy using the Facial Treatment Essence, as its light and absorbs easily into the skin. I decided to buy this and used an entire 15 ml bottle, it all went well, but realized I was getting clogged pores more and more often. Nothing bad, I kept using it. I also started to get lots of pimples, even though I was eating clean. I decided to ditch my makeup, thinking it is the culprit, no change at all. (And I HATE going out without at least a tinted moisturizer!)
It was devastating as more pimples were popping up, those painful, red angry ones. My complexion was pretty red too. My self esteem went down hill, and I kept buying new makeup hoping it would improve my skin. (Wasting a lot of $) I couldn't bear to look at people in the face because I thought they were looking at how awful my skin looked. After weeks, I realized THIS repair C was giving me the AWFUL teenage pimples!!! I stopped using it and my pores look A LOT smaller, and more even, and no new pimples are popping up and the old nasty ones are fading.
I would NEVER, EVER buy this again. Shamefully, I spent $185 PLUS TAX on "Acne in a Bottle" Now I am hoping someone will buy it off me on CL.
on 12/21/2014 6:12:00 AM
Age: 36-43
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Hazel
I really, really like this serum. It absorbs quickly into my skin, no scent, pricey, but then you only need a really small amount for your whole face. The results are clearly visible in the morning: my skin looks plump and radiant, even with my crazy schedule I look more awake and slept-in. I use it with the Facial Treatment Essence and I thought I could skip it, since it does contain the same ingredients, so why spend more money? I bought my second bottle of this serum in Bangkok and forgot it there at my friend`s house. So had to use another serum paired with the Facial Treatment Essence, and the results were not nearly as good. Then when I received my Repair C in the mail from my friend, I had ran out of the Treatment Essence, so I didn`t repurchase. So for 1 month I used only the serum. Again, the results were good, but not nearly as good as when I use both. I think the Facial Treatment Essence preps my skin so the serum can absorb better.
on 6/22/2014 1:58:00 PM
Age: 30-35
Skin: Acne-prone, Olive, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I've been using this for over a year now and I must say I can't live without it! This is the only product that has cured my acne! I've had adult acne for maybe 10 years and nothing would work. Prescription products will dry out my skin too much, turning it red. Over the counter stuff just didn't work. I eventually got use to the fact that I always have at least one pimple (if I'm lucky) on my face every day. Then I started using the Repair C. At first, I felt it didn't do much, but since the product is so expensive, I kept using it. By the time I finished, I felt my skin was improving, so I bought another bottle. One year later, my skin is now clear! Other than keeping my skin clear, I felt it doesn't do anything else. I still have acne scars that i'm now trying to get rid of, but the Repair C is a keeper if it keeps my skin forever clear.
on 2/9/2014 7:13:00 AM
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Other
I got two 15 ml bottles off sasa really cheap, so i can't really complain about the price too much. The issue with this is that I haven't really seen a marked difference with skin tone after using it. Its fairly moisturizing but you can get that with a lot of other reasonably priced products (clarins facial oils for example). I am fairly convinced that the petera is some sort of marketing ploy, a product is much more convincing if it has some sort of story or heritage doesnt it? Sk2 uses the story of the old sake brewers, BB cream was developed be some doctor for recovering patients and snail cream has some farmers in Argentina responsible for the concept.
Glycerin is cheap and hyaluronic acid can be found in a lot of other products. If its hyaluronic acid that your looking for, hada labo and juju cosmetics offer a range of products that offer you just that for a fraction of the price.
To be fair SK2 does produce really good eye cream, both the wrinkle specialist and the repair gel are amazing for people with dry/mature skin. This product however was meh.... so not something i recommend or repurchase.
on 12/4/2013 2:17:00 AM
Age: 25-29
Skin: Combination, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Black
I have been using this for a few days now. I don't really have too many problems with my skin save for the fact that I have a few white patches on my face (uneven skin tone).
It hasn't done anything for those patches (though I highly doubt any product can) but I will say this: my skin has become ridiculously soft to the touch !!
I am also using SK II Whitening Spots Dermdefinition and a Shiseido Emulsion cream on top of this. I wash and tone my face with Shiseido's Skincare line. I guess I will give it a month to see how well this product works. No complaints so far, though.
Popular Treatments (Face)
558 Reviews
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Our best selling white promotional budget mug with a splash of color added and can be filled with 11 oz, of your favorite beverage.
Our #1 best selling white promotional ceramic mug!
This BPA Free custom tumbler has a trendy stemless wine glass shape and can be used with or without a straw.
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ePromos is your best source for promotional products on the internet. We have one of the largest selections of promo items online - with over 15,000 products that can be custom imprinted with your company's logo by our Promotional Specialists. As one of the oldest and most experienced companies on the web, we'll wow you with our "Promo-Know-How"!


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Americans advance in early play on Day 4 at WimbledonKei Nishikori advanced to the third round at Wimbledon by beating Julien Benneteau 4-6, 6-4, 6-4, 6-2. There is tennis being played at Wimbledon - on one court, anyway. By 2.30pm, the sun was out and play was set to start across all courts at ... Equilibrio Informativo, 4 weeks ago
Air K gets bearings after bumpy start - The Japan News, 4 weeks ago
Nishikori bests Benneteau; Doi sends Pliskova packing - Japan Times, 4 weeks ago
36 images for julien benneteau
Herbert & Mahut win men's doubles final
French pair Herbert and Mahut win the men's doubles final in straight sets by beating Julien Benneteau and Edouard Roger-Vasselin 6-4, 7-6 (7-1), 6-3. The pair have now claimed two Grand Slam titles together having won the U.S. Open last year. ...BBC, 3 weeks ago Wimbledon 2016: Nicolas Mahut and Pierre First Post.com, 3 weeks ago Herbert and Mahut: Men's doubles final Official Web Site of Wimbledon, 2 weeks ago All-French men's doubles final for unseeded pair Official Web Site of Wimbledon, 3 weeks ago
Murray & Soares beaten by French duo
Watch the best of the action as Jamie Murray and Bruno Soares lose 6-4 6-4 6-7 6-7 10-8 to French pair Julien Benneteau and Edouard Roger-Vasselin in round four of the men's doubles on court 18. Watch more Wimbledon video here. UKBBC, 3 weeks ago Jamie Murray knocked out of doubles BBC, 3 weeks ago Murray/Soares, Bryan Brothers beaten in doubles Official Web Site of Wimbledon, 3 weeks ago Jamie Murray's Wimbledon hopes ended with quarter-final defeat in men's doubles Tennis.co.uk, 3 weeks ago
Nishikori tells Asian tennis players to muscle up
Provided by AFP Japan's Kei Nishikori returns to France's Julien Benneteau during their men's singles second round match on the fourth day of the 2016 Wimbledon Championships Asian players need to work on their strength in the gym in order to mix ...XinMsn, 4 weeks ago Kei Nishikori wins 3-1 at Wimbledon Tennis Championships Xinhua News Agency, 4 weeks ago Kei Nishikori vs Julien Benneteau live sore: Wimbledon 2016 live streaming International Business Times India, 1 month ago
UPDATE 3-Tennis-Wimbledon mens doubles quarterfinal results
July 6 (Gracenote) - Results from the Wimbledon Men's Doubles Quarterfinal matches on Wednesday Julien Benneteau/Edouard Roger-Vasselin beat 3-Jamie Murray/Bruno Soares 6-4 6-4 6-7(11) 6-7(1) 10-8 11-Raven Klaasen/Rajeev Ram beat 2-Bob Bryan/Mike ...Reuters UK, 3 weeks ago Tennis-Wimbledon mens doubles final result Reuters UK, 3 weeks ago UPDATE 1-Tennis-Wimbledon mens doubles semifinal results Reuters UK, 3 weeks ago UPDATE 26-Tennis-Wimbledon mens singles results Reuters UK, 4 weeks ago
More from: , Reuters UK...and 1 other sources
Tennis-Wimbledon order of play on Thursday
June 29 Wimbledon order of play on show courts on Thursday (all times GMT). CENTRE COURT (1200) Julien Benneteau (France) v Kei Nishikori-5 (Japan) Yen-Hsun Lu (Taiwan) v Andy Murray-2 (Britain) Eugenie Bouchard ...Reuters UK, 1 month ago Wimbledon order of play on Thursday Cyprus Mail, 1 month ago Wimbledon 2016: Friday's order of play Sky Sports, 4 weeks ago Wimbledon 2016: Murray beats Tsonga in thriller to reach 20th Major semi Equilibrio Informativo, 3 weeks ago
More from: NewsGrio, MySanAntonio...and 9 other sources
Wimbledon heartbreak for Murray and Soares
Julien Benneteau and Edouard Roger-Vasselin have inflicted a heartbreaking 6-4 6-4 6-7(11) 6-7(1) 10-8 defeat on Jamie Murray and Bruno Soares in the quarter-finals of the men's doubles at Wimbledon. The third seeds showed tremendous commitment ...Lawn Tennis Association, 3 weeks ago Soares slams Wimbledon umpires, says players are not robots Malay Mail, 3 weeks ago
Davis Cup: France to rely on newcomers against Czech
France team members (L-R) Nicolas Mahut, Pierre-Hugues Herbert, captain Yannick Noah, Jo-Wilfried Tsonga and Lucas Pouille pose for photographers after the International Tennis Federation Davis Cup quarter-final draw ceremony. PHOTO: AFP PRAGUE: ...The Express Tribune, 2 weeks ago New-look France set to stun Czechs in Davis Cup Bangladesh Sangbad Sangstha, 2 weeks ago
The final word: recapping The 130th Championships
There were times during another exhilarating edition of The Championships at Wimbledon when we could almost persuade ourselves we were in a Hollywood movie, so deliciously outlandish were some of the plotlines. And as every great film demands a ...Official Web Site of Wimbledon, 2 weeks ago
Andy Murray ends British three-year wait for Grand Slam
British number one Andy Murray beat Canadian sixth seed Milos Raonic to win his second Wimbledon title in the men's single's final on Sunday. There was also Murray's unrelenting court coverage. "The question is, am I going to make the most of it ...Equilibrio Informativo, 2 weeks ago Murray blunts Raonic for title Deccan Herald, 2 weeks ago Murray and Raonic advance as Thiem crashes out AOL UK, 4 weeks ago
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3 Reviews
I liked the recipe in general but wanted a bit more boldness in flavor, as well as wanted to use ingredients locally available here. Here is my modified ingredient list
1.5 lb. fresh albacore tuna
5-6 carabao mangoes
2 of big green avocados (florida style, not haas... available locally in the pacific islands)
1 cup calamansi lime juice
1/2 jalapeno or a few donne peppers
2 Tbsp chopped cilantro
1 tomato finely diced
salt and sugar to taste (about 1 tsp. salt and 2 Tbsp. sugar)
15 dashes hot sauce
Very nice ceviche! I served mine in mini wonton cups which were so stinking cute. I enjoyed the addition of mango. Next time I will add a bit more onion, a pinch of garlic and some cilantro. This has been in my to-do pile for about a year, so I am glad it's finally been made!


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I love my hunting dog. I loved<\i> my hunting dog -- I'm not very good at hunting.
Watch highlights from season one and find out why that's great news.
Get full episodes of your favorite shows on the Comedy Central app.
Unlimited streams and downloads of the best Comedy Central specials.
© 2015 Comedy Partners. All Rights Reserved. Comedy Central and all related titles, logos and characters are trademarks of comedy partners.


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Get into shape with our cycling-specific training DVDs. We have the Carmichael range, Video Cycling and tonnes of intense indoor spinning DVDs!
Turbo Training DVD's - Filmed from a riders perspective on a gyro stabilised camera platform.
View products
Spinervals are the original indoor cycling workout series and have a huge range of spinning DVDs for you to try out!
Struggling to get fit for the new season due to bad weather or dark nights - worry no more, achieve your goals with our series of training sessions featuring pro riders Mark Cavendish and Peter Kennaugh
Bored of your normal indoor training. Our video cycling DVD range will keep you motivated!
Yes there's more! It's all covered here, from nutrition to bike positioning and leg-strengthening DVDs!
Spinervals - Shake it Out
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text: 1 Review 1 Ratings Union Square Cafe's Tuna Club Sandwich Most Helpful Newest Highest Rating Wonderful flavors, just a bit to labor intesive to make on a regular basis. 0 people found this helpful. Was it helpful to you? [Yes] [No] FlaBeachBuns July 05, 2005 Show More Reviews Back To Top Union Square Cafe's Tuna Club Sandwich


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Taste of India
Total Time
Prep 1 min
Cook 5 mins
I drink this almost everyday. It is great way to energize yourself in the morning.
Ingredients Nutrition
- 2 frozen sliced bananas
- 3 ice cubes
- 118.29 ml strongly brewed black tea, at room temperature
- 78.07 ml milk
- 14.79 ml honey
- 0.59 ml ground cardamom
- 0.59 ml ground cinnamon
- Blend bananas and ice cubes in a blender until chunky mixture forms.
- Add remaining ingredients and blend until smooth.
Most Helpful
Reminds me of liquid medication that my mother had to force me to take.
This was okay....I had it this morning on the way to work. I had problems getting the bananas and ice to blend into a chunky mixture until I added the milk and tea. UPDATE: This was a pretty good start to the morning.....I think next time I''ll try peeling the bananas before freezing them!
I like it. I also put all the ingredients together in the blender and blend for a couple of secs. Note: I subsituted low fat yogurt and water for tea. Yummy.


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. . . promoting capitalist acts between consenting adults.
"'Bureaucrats: they are dead at 30 and buried at 60. They are like custard pies; you can't nail them to a wall." - Frank Lloyd Wright
Say what you mean, and mean what you say.(Off-topic grandstanding, trolling and spam is moderated. If it's not entertaining.)


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'We Suck in Colder Weather' Parody Pokes Fun at the South [VIDEO]
With all the cold weather, freezing rain and snow we have had here in Texas, this Zac Brown Band parody kind of sums it up for all of us, doesn't it?
With all the cold weather, freezing rain and snow we have had here in Texas, this Zac Brown Band parody kind of sums it up for all of us, doesn't it?
So we all remember back to school shopping with Mom and Dad when we were kids.
This is probably the most emotional thing you'll see all day, if not this week.
Thanks to the power of technology, Allen Zderdad was able to see the love of his life for the first time in more than a decade.
This guy strapped on a wingsuit and a set of GoPro cameras and flew through the mountains of Switzerland. FUN.
A selfie is not unusual. A marriage proposal is not unusual. Put them together, though, and you get something unusual.
Dan Williams, a student at Edmond Memorial High School in Oklahoma, spent the past summer earning extra money for someone very special ... actually, make that, 1,076 very special someones.
What happens when you mix Valentine's Day, 97 women, one diamond ring and a giant cake? You get a heckuva mess.
They say women like a man with a cool car. Well, now's the time to see if men like a woman who can handle a cool car.
It's being marketed as the 'world's dumbest app'. But, sometimes the
dumbest, simplest ideas can be the most brilliant.
A group of very talented guys called The Piano Guys on YouTube, decided they were going to go play a small concert for some of their favorite people, senior citizens.


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Product Description
Joined by Miyu, Yuki s younger sister, the five quickly rush Yuki to a hospital, where something seems terribly wrong. No one is there to help them and not a patient is in sight. In the midst of the confusion, Yuki disappears. The night of terror that ensues, where Ken, Rin, Motoki and Miyu must navigate the labyrinth-like corridors of the hospital as well as their own minds, are forced to confront their past, unearth long-suppressed memories, and test the resilience of their sanity.
Over 40 minutes of Extras
English Subtitles
English Dub
Does not disappoint....Catch this one if you can! --horrornews.net