text:
|Systematic (IUPAC) name
(S)-3-(aminomethyl)-5-methylhexanoic acid
|Clinical data
|Trade names
|Lyrica, others[2]
|License data
|Physical: Moderate[1]
Psychological: Moderate[1]
|Routes of
|By mouth
|Legal status
|Legal status
|Pharmacokinetic data
|High (≥90% rapidly absorbed; administration with food has no significant effect on bioavailability)[3]
|Protein binding
|Onset of action
|1.5 hours (3 hours with food)[4]
|Biological half-life
|6.3 hours[4]
|Renal (90% as unchanged drug; minor metabolites)[4]
|CAS Number
|ATC code
|β-isobutyl-γ-Aminobutyric acid, (S)-(+)-4-amino-3-(2-methylpropyl)butanoic acid, 3-isobutyl GABA
|Chemical data
|Molar mass
|159.23 g.mol−1
|(what is this?) (verify)
Pregabalin (PGN) marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder.[5][6][7] Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.[8] Some off-label uses of pregabalin include, restless leg syndrome, migraine, social phobia, panic disorder, mania, bipolar disorder, and alcohol withdrawal.[9][10]
Common side effects include: sleepiness, confusion, trouble with memory, poor coordination, dry mouth, problem with vision, and weight gain.[6] Potentially serious side effects include angioedema, drug misuse, and an increased suicide risk.[6] It is moderately addictive both physically and psychologically.[1]
Pregabalin is a 3-alkylated derivative of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), or a GABA analogue.[11][12] Pregabalin is a potent gabapentinoid and a close structural analogue of GABA, as well as of gabapentin and gabapentin enacarbil, GABOB, baclofen, and phenibut.[13][14] Pregabalin binds to the α2δ subunit-containing voltage-gated calcium channels and is a substrate of the system L-neutral amino acid transporter. It modulates calcium influx at nerve terminals and this may account for its therapeutic effect on neuropathic pain, anxiety, and seizures.[4][15]
Pregabalin has potential to be misused and abuse of the drug may lead to physical and psychological dependence. The Drug Enforcement Administration placed pregabalin, including its salts, and all products containing pregabalin into Schedule V of the Controlled Substances Act.[16][17][18] There is to be no generic version available in the United States until 2018.[19] A generic version is available in Canada and the United Kingdom.[20][21] In the US it costs about 300-400 USD per month.[6]
- 1 Medical uses
- 2 Side effects
- 3 Overdose
- 4 Drug interactions
- 5 Pharmacology
- 6 History
- 7 Society and culture
- 8 See also
- 9 References
- 10 External links
Medical uses[edit]
Pregabalin is useful when added to other treatments, when those other treatments are not controlling partial epilepsy.[22] Its use alone is less effective than some other seizure medications.[23]
It is unclear how it compares to gabapentin for this use.[23]
Neuropathic pain[edit]
The European Federation of Neurological Societies recommends pregabalin as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain.[24] A minority obtain substantial benefit, and a larger number obtain moderate benefit.[25] Other first line agents, including gabapentin and tricyclic antidepressants, are given equal weight as first line agents, and unlike pregabalin, are available as less expensive generics.[26]
Pregabalin is not recommended for certain other types of neuropathic pain such as pain that of trigeminal neuralgia or HIV infection[27] and its use in cancer-associated neuropathic pain is controversial.[27] There is no evidence for its use in the prevention of migraines and gabapentin has been found not to be useful.[28] It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.[29][30]
Pregabalin is generally not regarded as efficacious in the treatment of acute pain.[25] In clinical trials examining the utility of pregabalin for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects.[29] Several possible mechanisms for pain improvement have been discussed.[31]
Anxiety disorders[edit]
The World Federation of Biological Psychiatry recommends pregabalin as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such as SSRIs as first line treatment for obsessive-compulsive disorder and post-traumatic stress disorder.[32] It appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence.[33][34]
Therapeutic effects of pregabalin appear after 1 week of use and is similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms[35] Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep.[35] and produces less severe cognitive and psychomotor impairment compared to those drugs; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.[35][36]
Side effects[edit]
Pregabalin has been shown to produce therapeutic effects that are similar to other controlled substances. In a study with recreational users of sedative and hypnotic drugs, a 450 mg dose of pregabalin resulted in subjective ratings of a "good drug effect" and "high" and "liking" similar to 30 mg of diazepam. In clinical studies, pregabalin showed a side effect profile similar to other central nervous system depressants.[37]
Adverse drug reactions associated with the use of pregabalin include:[38][39]
- Very common (>10% of patients): dizziness, drowsiness.
- Common (1–10% of patients): blurred vision, diplopia, increased appetite and subsequent weight gain, euphoria, confusion, vivid dreams, changes in libido (increase or decrease), irritability, ataxia, attention changes, feeling high, abnormal coordination, memory impairment, tremors, dysarthria, parasthesia, vertigo, dry mouth and constipation, vomiting and flatulence, erectile dysfunction, fatigue, peripheral edema, drunkenness, abnormal walking, asthenia, nasopharyngitis, increased creatine kinase level.
- Infrequent (0.1–1% of patients): depression, lethargy, agitation, anorgasmia, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, hypoglycaemia, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, kidney calculus
- Rare (<0.1% of patients): neutropenia, first degree heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis, suicidal thoughts or behavior.[40]
Following abrupt or rapid discontinuation of pregabalin, some people reported symptoms suggestive of physical dependence. The FDA determined that the substance dependence profile of pregabalin, as measured by a patient physical withdrawal checklist, was quantitatively less than benzodiazepines.[37] Even people who have discontinued short term and or long term use of pregabalin have experienced withdrawal symptoms, including insomnia, headache, nausea, anxiety, diarrhea, flu like symptoms, nervousness, major depression, pain, convulsions, hyperhidrosis and dizziness.[41]
Several renal failure patients developed myoclonus while receiving pregabalin, apparently as a result of gradual accumulation of the drug. Acute overdosage may be manifested by somnolence, tachycardia and hypertonicity. Plasma, serum or blood concentrations of pregabalin may be measured to monitor therapy or to confirm a diagnosis of poisoning in hospitalized patients.[42][43][44]
Drug interactions[edit]
No interactions have been demonstrated in vivo. The manufacturer notes some potential pharmacological interactions with opioids, benzodiazepines, barbiturates, ethanol (alcohol), and other drugs that depress the central nervous system. ACE inhibitors may enhance the adverse/toxic effect of Pregabalin. Antidiabetic Agents (Thiazolidinedione): Pregabalin may enhance the fluid-retaining effect of Antidiabetic Agents (Thiazolidinedione).[45]
Pregabalin is a potent ligand for the α2δ subunit in the central nervous system.[46][47] Pregabalin possesses analgesic, anticonvulsant, and anxiolytic activity.[48] Although, pregabalin is an analogue of GABA, it does not bind directly to GABAA, GABAB, or benzodiazepine receptors. Nor does it block sodium channels and is not active at opioid receptors. Gabapentinoids, such as pregabalin, are α2δ subunit modifiers that affect GABA. In contrast to the distribution of α2δ-1 and α2δ-2 subunits binding correlates partially with GABAergic neurons.[49] Reports concerning the effects of pregabalin on neural GABA concentrations are conflicting.[50][51][52] Pregabalin increases the density of GABA transporter proteins and increases the rate of functional GABA transport.[53]
Pregabalin is a 3–10 times more potent anticonvulsant and 2–4 times more potent analgesic than gabapentin.[54][55]
Pregabalin is 6 times more potent than gabapentin in binding affinity.[10][56][57]
The biological half-life for pregabalin is 6.3 hours.[4]
Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occurring within one hour. Pregabalin oral bioavailability is estimated to be greater than or equal to 90% and is independent of dose. The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay in Tmax (time to reach Cmax) to approximately 3 hours.[4] Administration with food, however, has no clinically significant effect on the extent of absorption.[3]
Pregabalin has been shown to cross the blood–brain barrier in mice, rats, and monkeys. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats. In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L/kg and is not bound to plasma proteins.[3]
Pregabalin undergoes negligible metabolism in humans.[58] In experiments using nuclear medicine techniques, it was revealed that approximately 98% of the radioactivity recovered in the urine was unchanged pregabalin. The major metabolite is N-methylpregabalin.[3]
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug.[3] Renal clearance of pregabalin is 73 mL/minute.[59]
Pregabalin was synthesized in 1990 as an antiepileptic. It was invented by medicinal chemist Richard Bruce Silverman at Northwestern University in the United States.[60] The drug was approved in the European Union in 2004. Pregabalin received U.S. FDA approval for use in treating epilepsy, diabetic neuropathic pain, and postherpetic neuralgia in December 2004, and appeared on the U.S. market in fall 2005.[61]
In June 2007, the FDA approved Lyrica as a treatment for fibromyalgia. It was the first drug to be approved for this indication and remained the only one until duloxetine gained FDA approval for the treatment of fibromyalgia in June 2008.[62]
Generic versions of pregabalin became available in Russia in 2011,[63] in Canada in 2013, Iceland 2014,[64] and are expected to become available in the European Union and the U.S. in 2016 and 2018 respectively.[65]
Society and culture[edit]
Legal status[edit]
- US: Pregabalin is a Schedule V controlled substance and has potential for abuse.[37][66]
- Norway: Pregabalin is in prescription Schedule C, the lowest schedule, although it has been suggested that it be moved to Schedule B alongside benzodiazepines.[67][68]
Regulatory approval[edit]
In the United States, the Food and Drug Administration (FDA) has approved pregabalin for adjunctive therapy for adults with partial onset seizures, management of postherpetic neuralgia and neuropathic pain associated with spinal cord injury and diabetic peripheral neuropathy, and the treatment of fibromyalgia.[69] Pregabalin has also been approved in the European Union and Russia (but not in US) for treatment of generalized anxiety disorder.[70][71]
Pregabalin is marketed by Pfizer under the trade name Lyrica. Pfizer described in an SEC filing that the drug could be used to treat epilepsy, postherpetic neuralgia, diabetic peripheral neuropathy and fibromyalgia. Lyrica was promoted for other uses which had not been approved by medical regulators up until 2009. For this practice, with three other drugs, Pfizer was fined a record amount of US$2.3 billion by the Department of Justice.[72] Lyrica sales reached a record US$3.063 billion in 2010.[73] Lyrica is one of four drugs which Pharmacia & Upjohn, a subsidiary of Pfizer, in 2009 pleaded guilty to misbranding "with the intent to defraud or mislead". Pfizer agreed to pay US$2.3 billion (GB£1.4 billion) in settlement, and entered a corporate integrity agreement. Pfizer illegally promoted the drugs and caused false claims to be submitted to government healthcare programs for uses that were not approved by the U.S. Food and Drug Administration (FDA).[72]
Intellectual property[edit]
Northwestern University invented pregabalin and holds a patent on it, which it exclusively licensed to Pfizer.[74][75] That patent, along with others, was challenged by generic manufacturers and was upheld in 2014, giving Pfizer exclusivity for Lyrica in the US until 2018.[76][77]
In the United States as of 2015 the cost is between 3.69 and 5.52 USD per 150 mg tablet.[78]
See also[edit]
- GABA analogue
- 4-Methylpregabalin
- Gabapentin (Neurontin, Gabarone)
- Gabapentin enacarbil (Horizant)
- Atagabalin
- Imagabalin
- Mirogabalin
- Phenibut (Noofen, Citrocard)
- Baclofen (Gablofen, Lioresal)
- Gabapentinoids
- ^ a b c d Schifano F (2014). "Misuse and abuse of pregabalin and gabapentin: cause for concern?". CNS Drugs 28 (6): 491–6. doi:10.1007/s40263-014-0164-4. PMID 24760436.
Gabapentinoids (e.g. pregabalin and gabapentin) are widely used in neurology, psychiatry and primary healthcare ... Although at therapeutic dosages gabapentinoids may present with low addictive liability levels...
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- ^ a b Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J (August 2012). "The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis". Anesth. Analg. 115 (2): 428–42. doi:10.1213/ANE.0b013e318249d36e. PMID 22415535.
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- ^ Wensel TM, Powe KW, Cates ME (March 2012). "Pregabalin for the treatment of generalized anxiety disorder". Ann Pharmacother 46 (3): 424–9. doi:10.1345/aph.1Q405. PMID 22395254.
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- ^ a b c Bandelow, B.; Wedekind, D.; Leon, T. (Jul 2007). "Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention". Expert Rev Neurother 7 (7): 769–81. doi:10.1586/14737184.108.40.2069. PMID 17610384.
- ^ Owen, RT. (Sep 2007). "Pregabalin: its efficacy, safety and tolerability profile in generalized anxiety". Drugs Today (Barc) 43 (9): 601–10. doi:10.1358/dot.2007.43.9.1133188. PMID 17940637.
- ^ a b c Drug Enforcement Administration, Department of Justice (July 2005). "Schedules of controlled substances: placement of pregabalin into schedule V. Final rule". Federal register 70 (144): 43633–5. PMID 16050051. Retrieved 2012-01-22.
- ^ Pfizer Australia Pty Ltd. Lyrica (Australian Approved Product Information). West Ryde: Pfizer; 2006.
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- ^ Murphy, N.G.; Mosher, L. (2008). "Severe myoclonus from pregabalin (Lyrica) due to chronic renal insufficiency". Clinical Toxicology 46 (7): 594. doi:10.1080/15563650802255033.
- ^ Yoo, Lawrence; Matalon, Daniel; Hoffman, Robert S.; Goldfarb, David S. (2009). "Treatment of pregabalin toxicity by hemodialysis in a patient with kidney failure". American Journal of Kidney Diseases 54 (6): 1127–30. doi:10.1053/j.ajkd.2009.04.014. PMID 19493601.
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- ^ Dolphin, Annette C. (2012). "Calcium channel auxiliary α2δ and β subunits: Trafficking and one step beyond". Nature Reviews Neuroscience 13. doi:10.1038/nrn3311. Errata is: Dolphin, Annette C. (2012). "Calcium channel auxiliary α2δ and β subunits: Trafficking and one step beyond". Nature Reviews Neuroscience 13 (9): 664. doi:10.1038/nrn3317.
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- ^ Langreth, Robert (June 29, 2016). "Decoding Big Pharma's Secret Drug Pricing Practices". Bloomberg. Retrieved 15 July 2016.


text:
Crazy Substitute Teachers
Enjoy, NG4.04 / 5.00 1,480 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner3.98 / 5.00 2,417 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.91 / 5.00 3,895 Views
I must vote five for referring to Final Fantasy!!!
Ehh...A little dull
Its alittle dull and dumb.I really dont care if you make fun of LF or not,thats really none my concern.Just submit something with some meaning next time.
all ur work is hilarious
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Okay Legendary Frog will be highly offended, and hopfully Tom Flup would be offended, cause this is more like a huge spoof of his characters. I hope Tom, and Wade Flup, and the staff of newgrounds reads, and watches this. you're be in big trouble.
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subset: commoncrawl


text:
Melbourne Storm won the battle of the National Rugby League's only unbeaten teams to emerge 17-10 winners over South Sydney at Sydney's Olympic stadium on Saturday.
The world club champions showed they will again be the team to beat for this season's NRL title with a clinical performance against the much-improved Rabbitohs before almost 33,000 fans.
It was the Storm's greater composure under the scheming control of their influential scrum-half Cooper Cronk that proved the difference in a three tries to two victory.
Melbourne capitalised on South Sydney errors to lead 12-0 at half-time but were outscored 10-5 in the second half as the Rabbitohs tested their defence through the powerful running of the Burgess brothers, Sam and George.
Greg Inglis scored a try for the first time against his old club to get Souths back into the contest at 12-6 in the 48th minute before British standoff Gareth Widdop's slick footwork got him over the try-line six minutes later.
Souths pulled to within a converted try at 16-10 with a try from winger Andrew Everingham eight minutes later, before Cronk kicked a drop goal to open the margin with four minutes remaining.
There was late drama when Storm's Test fullback Billy Slater was sin-binned after a try-saver on flying Rabbitohs winger Nathan Merritt with less than two minutes remaining, but time and a relentless Storm were against the Rabbitohs.
Melbourne, who beat Leeds for the world club championship in February, are now unbeaten in 14 games since last July and are now the only unbeaten team in this season's NRL competition.


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Fixed-Price - Expert ($$$) - Est. Budget: $100 - PostedSkills: Financial Management Business valuation Certified Public Accountant (CPA) Financial Accounting
We are on the verge of breaking through as a firm, and we would like to make sure our financial records are accurate for business, legal, and overall overview of the firms financial health. Must be well versed in business accounting Must have business legal knowledge Must be a U.S Citizen and registered accountant Responsibilities: Record keeping Financial planning Tax filing Most importantly, financial advising. $100/mo fixed for standard operation Variable rate for non-standard operations


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The new home of
2 reviews
This holiday property is located in an historic villa that has preserved the architectural charm of this former palace of the reigning family of Monte Carlo. There are panoramic views of the sea, coast of Cap Martin, the city of Mentone and Monaco. The house, which has been dug into the rocks, has private access and shared grounds. From its private roof terrace, you can admire a breathtaking view of the cliffs of the Balzi Rossi and nearby Mentone. The property consists of two floors, which are connected by a steep staircase. The open-plan living area and shower room are on the ground floor, and a steep staircase leads directly into the double bedroom and separate toilet. The property is located in an exclusive estate with shared areas, where guests can admire various botanical rarities or share the swimming pool and tennis court. Nearby places to visit include Grimaldi Inferiore (all kinds of shops) and Mentone, with its famous 'Giardini di Villa Hanbury' (beautiful botanical garden from 1867), both 1km, the Principality of Monaco 10km, the city of San Remo 28km or Nice 30km. There is a golf course and riding school within 10km.
Steps to entrance. Ground floor: Living room with double sofa bed/dining room/kitchen. Shower room with toilet. Steep, open-tread stairs to first floor: 1 double bedroom. Separate toilet.
CH. Satellite TV. Gas/elec cooker. W/machine. D/washer. Shared garden and furniture. Terrace. Parking (1 car). Shared outdoor swimming pool (20m²). NB: Steps to terrace. Steps and drops in grounds.
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These lovely holiday properties are 250m (835 feet) above sea level with stunning views and are just a few minutes from the beach. Casa degli Ulvi (ref ILL377) is an elegant and comfortable home with refined furniture, paintings, tapestries, a bookcase filled with Italian and English literature and a large stone fireplace - all elements which make it an ideal dwelling for all seasons. Located on the first floor of a former farmhouse built in 19th century, the residence is in fact fully independent, with a nice garden surrounded by stone walled terraces with olive trees and a spacious pergola where al fresco dining is possible with views of the sea throughout the year. An internal staircase leads to the roof terrace with an extensive view over sea and mountains. The owners occasionally live on the ground floor of the house. Ref ILL376 is a detached house, with its two floors connected by a spiral staircase. It has a large, partially enclosed garden, and an outdoor shower with spring water. The properties are in an ideal location for exploring the Cinque Terre area including the Sanctuary of the Madonna di Monte Nero in Riomaggiore, 35km and the beautiful medieval village of Portovenere. The centre of Bonassola is 1.4km and 6 km from Levanto.
Living room with sofa bed/dining room/kitchen. Steep, spiral, open-tread stairs to first floor: 2 bedrooms: 1 double, 1 single. Shower room with toilet.
Central heating. H/chair. Satellite TV. Gas/electric cooker. W/machine. Fridge. Wi-fi. Terrace and furniture. BBQ. Shared grounds. Parking (1 car). No smoking. NB: Steep access road with very sharp bends. Drops within grounds.
1 reviews
This ground floor holiday apartment, ideal for couples or a small family, is located in a semi-detached house, just a few minutes from the beaches of Bordighera and just 2km from the motorway (some traffic noise may be heard). It has some exposed stone walls giving the property a rustic feel, and a large garden to enjoy which is characterised by the typical vegetation of the Riviera dei Fiori, famous for its palm trees. The property also benefits from a terrace with patio furniture, ideal for dining al fresco. Bordighera is an elegant town and boasts the most sunshine hours in Europe. It also has historic mansions, a beautiful beach promenade and one of the best-kept old towns on the coast. The location of the property is ideal for trips to nearby San Remo, 15km and Monte Carlo, 30km.Explore the beautiful hinterland, with medieval hamlets in the mountains that drop steeply down to the sea, and the coast with marinas and long white pebble beaches. The thermal baths of Pigna are approximately 16km from the property.
All on ground floor: Living room with double sofa bed/dining room. Kitchen with dining area. 1 double bedroom. Shower room with bidet and toilet.
CH. Satellite TV. Gas/elec cooker. W/machine. D/washer. Wi-fi. Garden and furniture. BBQ. Parking (1 car). No smoking. NB: Steps to garden.
This ground floor holiday apartment is situated 5km from the sea at Recco, a small village in Golfo Paradiso, between the village of Portofino and the town of Genoa. An equipped outdoor area is at guests' disposal. Set in green landscape, the apartment is not far from the Liguarian coast. Cinque Terre, Portovenere, Golfo dei Poeti, the Gulf of Tigullio, Portofino and Santa Margherita Ligure are all easily accessible by car or by boat. In Recco, a firework show takes place in the first week of September.
All on ground floor: Living room with sofa bed/dining room/kitchen. 1 double bedroom with additional single (for child). Bathroom with toilet.
Open fire in living room. CH. DVD. W/machine. Garden with terrace and furniture. On road parking. NB: Drop from terrace.
This pleasant semi-detached house, adjoining a B&B, is set in an elevated position on the hills of Sanremo, with stunning sea views. The house is surrounded by wonderful views typical of the Riviera, with Mediterranean trees and it is only 5km from the beautiful sandy beaches. Guests have access to an outdoor area with sea views for sunbathing, shared with the guests of the B&B. Near the entrance of the house is a private, partially enclosed garden with sun terrace. The location is ideal to enjoy the beach life at Sanremo, the famous 'city of flowers', or visit the nearby Côte d'Azur in a day trip. Close to the French border, you can also admire the Hanbury Botanic Gardens and the area of the Balzi Rossi (Red Rocks). Bike lovers will find Europe's longest coastal bike and pedestrian path in Sanremo, a 20km route to the sandy beaches of San Lorenzo al Mare. A short distance from the property there are downhill and motocross tracks. On request it is possible to have breakfast and arrange trips on a sailing boat.
Steps to entrance. Living/dining room with double sofa bed/kitchen. 1 double bedroom. Shower room with toilet.
CH. Satellite TV. Gas cooker. M/wave. Wi-fi. Garden with terrace and furniture. Shared grounds with furniture. BBQ. Parking (1 car). No smoking. NB: Steps to terrace. Steps in grounds.
This first floor holiday apartment, set in the owner's semi-detached house, is in an exceptional location overlooking the sea of Bordighera. Guests will enjoy the panoramic terraces, as the view over the Riviera with palm trees is truly beautiful. The elegant city, with its historic mansions and promenade, is one of the most well-kept historic old towns on the coast. Also interesting is the beautiful hinterland, with historic medieval villages in the mountains, which steeply descend to the sea, and the coastline with ports and long white pebble beaches.
All on first floor: Living/dining room/kitchen. 3 bedrooms: 2 double, 1 single. Bathroom with shower with toilet. Shower room with toilet.
Open fire in living room. CH. DVDs. Gas/elec cooker. M/wave. W/machine. D/washer. Internet connection. Terrace and furniture. Parking (2 cars)
This cosy, semi-detached cottage is 17km away from the beginning of the Cinque Terre and located between the forests and hills of the Val di Vara, the first biological area with environmental certification. The property boasts several spacious outdoor areas, including a private equipped outdoor area and a shared pergola, where you can enjoy breakfast or dinner. The discreet home owner lives on-site. Outdoor enthusiasts will enjoy the many country paths, which can be discovered by mountain bike or on horseback. This property is in an ideal base to reach the localities, such as Cinque Terre, Levanto, Bonassola and Sestri Levante. On-site you may encounter the farmyard animals. The property is accessed via an unpaved access road, with curves and slopes (unsuitable for low or sports cars).
Steps to entrance. All on first floor. Living room with double sofa bed/dining room/kitchen with tiled floor. 2 bedrooms: 1 double, 1 twin. Bathroom with toilet.
Woodburner in living room. CH. Satellite TV. Gas/electric cooker. Terrace. Shared grounds. Shared garden furniture. Barbecue. Parking (2 cars). No smoking. NB: Steps in property. Steps (no handrail) and drops within grounds.
This wonderful, detached, air-conditioned stone holiday house, is set in an elevated position separated from the coast by a road reserved solely for residents. From the large terrace of the house there is a lovely view of the sea just metres away. Within the same property, completely fenced off and closed by a gate, is another house where the owners conveniently live. 10m across the street is access to a small beach of gravel and rocks. The property is located just 1.5km from the center of Imperia (Oneglia), 24km from Sanremo, 85km from Nice and 115km from Genoa.
Ground floor: Living/dining room/kitchen. Room with 2 single beds. Shower room with toilet. Separate toilet. First floor: 2 bedrooms: 1 double with step to en-suite shower and toilet, 1 bunk. Bathroom with shower attachment, bidet and toilet.
CH. Air conditioning. Satellite TV. Elec cooker. M/wave. W/machine. D/washer. Garden with terrace and furniture. Parking (1 car). NB: Steps, drops and well in garden. Fenced drop from road to terrace.
This first floor, holiday apartment is 5km from the sea of Recco, set in the small village of Golfo Paradiso, between the village of Portofino and the town of Genoa. In an idyllic setting surrounded by green landscape, the apartment is not far from the Ligurian coast. Explore the rugged coastline of Cinque Terre, the riviera village of Portovenere, Golfo dei Poeti, the Gulf of Tigullio, as well as the fishing village of Portofino and the seaside resort of Santa Margherita Ligure, which are all easily accessible by car or by boat. In Recco a firework show takes place in the first week of September. Can be booked with refs ILL318 and ILL320.
10 steps to entrance. All on first floor: Living room with 2 sofa beds (for children) and sloping ceiling/dining room/kitchen with breakfast area. 2 double bedrooms. Bathroom with toilet. Shower room with toilet.
CH. DVD. Gas/electric cooker. W/machine. Terrace and furniture. Balcony. Natural grounds. On road parking. NB: Steps to terrace.
Situated in the lush green Vara Valley, this three-storey detached property is only 1.3km from Varese Ligure. The terrace is furnished for al-fresco dining, and a barbecue is provided for you to try your culinary skills. In the garden are fruit trees and crops cultivated by the owner. The River Vara passes the front of the property, and is ideal for fishermen. The property is situated back from the main road and is accessed by a long narrow lane. This is an ideal location for visiting the famous bays of Baia del Silenzio (Bay of Silence), and Baia delle Favole (Bay of Fairy Tales), named in honor of Danish writer, Hans Christian Anderson, both 28km away. Also worth a visit is the renowned Cinque Terre area with Bonassola, 44km away, and Monterosso, 47km away. Genoa, the city of art and culture is 72km away, and fashionable Portofino, 56km away. Outdoor enthusiasts can enjoy trekking, mountain biking, horse riding, tennis and golf, and there is an adventure park, 10km away.
All on ground floor: Living room. Kitchen/dining room. 3 double bedrooms. Bathroom with bath, shower cubicle and toilet.
Woodburner in living room. CH. Satellite TV. Gas/elec cooker. M/wave. W/machine. Shared garden. Terrace with furniture. BBQ. Parking (3 cars). No smoking. NB: Steps from terrace to grounds. Drops in grounds.
This fantastic terraced holiday accommodation is set on three floors and located close to the old slate quarries of Lavagna, a pretty village on the Ligurian Riviera. Inside, this property offers a welcoming atmosphere with its charming furnishings. The outdoor area is characterized by a pleasant pergola with wood stove and a relaxation area. Providing easy acces, the house is on the route of the Alta Via of the Ligurian Mountains.
Step to entrance. Ground floor: 1 twin bedroom. Separate WC. First floor: Living/dining room/kitchen. Second floor: 1 double bedroom with 2 additional singles (for children). Shower room with toilet.
CH. Cot. Satellite TV. Gas cooker. W/machine. Garden and furniture. Balcony. BBQ. On road parking. No smoking.
All on first floor: Living room with double sofa bed/dining room/kitchen with beams and tiled floor. 3 bedrooms: 2 double, 1 single. Bathroom with bath, shower attachment and toilet. Shower room with toilet. Spiral, open-tread stairs to roof terrace.
Open fire in living room. H/chair. Satellite TV. DVD. Gas/electric cooker. W/machine. Fridge. Freezer. Wi-fi. Garden with terraces and furniture. BBQ. Parking (1 car). No smoking. NB: Steep access road with very sharp bends. Drops within grounds.
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Jonah Hex travels to Mexico just in time for the Dia De Los Muertos celebration, and is hired by a spurned husband seeking revenge on the man who stole his wife's heart. But Hex will have to tread carefully, or he will face the wrath of...the Matador!
SDCC: Marvel: Spider-Man and His Amazing Friends Panel
Comic Books


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This is your resource to discuss support topics with your peers, and learn from each other.
I see there are posts regarding the buggy eyelidmanager provided by RIM. How that manager passed unit tests nobody knows.
Here's another bug:
Take the eyelidmanager demo that comes with blackberry eclipse plugin 1.3. Now add a banner to that screen like this:
this.setBanner(new CustomLabelField("sdfsdfsdf"));
Run the demo.
You'll see that the bottom eyelid is now pushed off the screen, thus not honouring the API doc:
"This eye blink displays fields along the top and bottom of the screen for a short period of time"
It did not do that!


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Gaming WireWhether it's a Last Lei, the World's Largest Bachelorette Party or a private soiree inside the Barbie Suite, Las Vegas venues are working to make themselves stand out in a sea of bachelorette options.
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The Children of Chabannes
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In the spirit of Louis Malle s Au Revoir les Enfants and Steven Spielberg s Schindler s List, the Emmy® Award-winning film THE CHILDREN OF CHABANNES has been praised as splendid, informative and emotionally involving (Los Angeles Times) and called a seamless memoir of courage and a tribute to the human spirit. (New York Daily News).
A magical World War II tale of courage, resilience and love, THE CHILDREN OF CHABANNES reveals the untold story of how the people in a tiny village in unoccupied France chose action over indifference to save the lives of 400 Jewish refugee children. Returning to the forgotten corner of France with her father and uncle (two of the saved children), filmmaker Lisa Gossels and co-director Dean Wetherell movingly recreate the joys and fears of daily life in Chabannes during the war. Through warm and wonderful accounts from the educators, townspeople and from the children themselves, we see how this oasis of hope is shattered in August of 1942, when the war reached the doorsteps of the chateau where these children lived.
A celebration of human kindness, THE CHILDREN OF CHABANNES delivers a profound message of tolerance. The film documents the remarkable efforts made by the citizens of Chabannes, who risked their lives and livelihoods to protect these children, simply because they felt it was the right thing to do.
Special Features
- Feature-length French Language Version; Children s Art Gallery; Chateau Journal Pages; Filmmaker Biographies; Trailer
Special Features
- Children's art gallery
- Chateau journal pages
- Filmmaker biographies
- Theatrical trailer
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Top Customer Reviews
The interviews with the survivors, including the teachers, gives a good picture of the life there. The many photos and written accounts round out the documentary. Very well done!
than I imagined. It was wonderful. I thought of a hundred ways to use this in school...ok, I may be exaggerating, but it is going
to be a great asset to our curriculum. I cried at a few beautiful statements which I don't do easily. The members of this crew are to be congratulated for a job well done! Guess I better have tissues ready in my classroom. The music was perfect...and the camera shots, dialogue, and updates on the "children" added a valuable, insightful component to this award-winning testimonial!
Between 1939 and 1943, Chabannes was the location of choice by the Oeuvre de Secours aux Enfants, or OSE, a Jewish social service organisation that placed 400 German-Jewish children at an old chateau under Feliz Chevrier, a non-Jew. The children ranged in age between 2 and 17. Though Chevrier died in 1962, some of his colleagues and secretary are featured in this documentary. Most notably featured are the Paillassou sisters who were schoolteachers, Rachel Pludermacher, the first teacher recruited by the OSE to instruct Jewish refugee children and many other remarkable people.
The documentary is very engaging as it features accounts by the surviving children and of course, the amazing and courageous townspeople who risked everything to protect them. It is a testament to a community that refused to give in to the Nazi tyrants - simple, ordinary people who did extraordinary good things in a horrific time.
In the 1940's, Charbannes was a rural village of modest farmers known for their "republican" sentiments and their stolid disbelief in the exhortations of Vichy propaganda. All of the Jewish children who were housed, fed and schooled in the Chateau of Charbannes were refugees from Nazi-occupied Europe. Some of them had narrowly escaped concentration camps in Germany. At the chateau, they led a safe, nurtured existence until 1943, when the inevitable quotas for death camp transport were issued in earnest by the Vichy regime. Despite the available depth of Holocaust literature, one cannot fail to feel shock and dismay at hearing the Charbannes rescuers and survivors recall how Vichy officials demanded exhaustive details concerning innocent, traumatized Jewish orphans. To the everlasting honor of the OSE staff and French teachers at Charbannes, the children of the chateau were dispersed by the Charbonnes rescuers into the local forests and later guided to refuge elsewhere.
"The Chateau of Charbannes" is a wholly uplifting and successful work, laden with the gleam of the French rescurers, teachers and refugee children who went on to live productive, meaningful lives.Read more ›
Most Recent Customer Reviews
Amazing story, heartbreaking but one that makes your spirits soar as well. A true reminder of the goodness in the world fighting against evil.Published 2 months ago by TW
Interesting movie. It's in french. Worth the trouble to watch this one. Teaches the worth of music in the ives of us all.Published 3 months ago by Lildi
Vivement qu'on en fasse une version française!
I can't wait the French version!!!
From 1939 and during the fall, partition, and the unoccupied zone of France in the 1940s during World War II, there is a obscured incident
which should be given renewed public... Read more
I love history of people and places... true stories of heros... saving children... and the follow-up of the lives of both children and teachers, etc.Published on March 31, 2014 by Seeker of Truth
Although he didn't appear in the film, my late father was one of the 500 Jewish children who were rescued by the incredibly brave and good people depicted in the film. Read morePublished on June 13, 2013 by nobbysbev
Extraordinary documentary about the people of the Creuse region of France who, during World War ii courageously opened their homes and schools to hundreds of Jewish immigrant... Read morePublished on September 29, 2011 by Scadhog
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Star Trek Beyond
The Star Wars-ification of Star Trek continues; better than the others, but still not good enough.
The Star Wars-ification of Star Trek continues; better than the others, but still not good enough.
It's almost as if the writers were simply using ideas left over from other Ice Age scripts that are about as fresh as the wind…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Ken Loach's "I, Daniel Blake" wins the Palme d'Or at the 69th Cannes Film Festival.
Barbara Scharres on the cats of Cannes 2016.
Wednesday, July 18, is the 20th anniversary of our marriage. How can I begin to tell you about Chaz? She fills my horizon, she is…
This movie is trying to kill these women, but they endure.
Writers at RogerEbert.com pick their favorite movies featuring star-crossed lovers.
Writers at RogerEbert.com pick their favorite movies featuring aliens and UFOs.
CNN Films and Kartemquin Films receive NATAS Best Documentary Emmy nomination for Roger Ebert film "Life Itself."
A report from SDCC on an actor who has been in all three of the new "Star Trek" films. Well, sorta.
* This filmography is not intended to be a comprehensive list of this artist's work. Instead it reflects the films this person has been involved with that have been reviewed on this site.
Robert Rodriguez adapts the George Clooney-Salma Hayek vampire thriller for his El Rey network.
Marie writes: Behold a truly inspired idea...Age 8: Eileen's pink creature It started with a simple idea: to make a recognizable comfort toy for her 4 year-old son Dani, based on one of his drawing. His school had asked the children to bring in a toy from home; an emergency measure in the event of a tantrum or crying fit. Fearing he might lose his favorite, Wendy Tsao decided to make Dani a new one. Using a drawing he often made as her guide, she improvised a plush toy snowman. Five years later, Wendy Tsao has her own thriving home-based craft business - Child's Own Studio - in which she transforms the imaginative drawings of children into plush and cloth dolls; each one handcrafted and one-of-a-kind. She receives requests from parents all over the world; there's 500 people on waiting list. Note: kudos to club member Sandy Kahn for submitting the piece.
Absolute silence while the Warner logo, the name of the production company and the title of the movie are displayed on the screen. Suddenly, we see ourselves orbiting the Earth while a cacophony of radio and television transmissions confuses us by their sheer volume and sound pollution they cause. Then, slowly, we begin a journey throughout the universe that will last for the next few minutes, taking us far from our old and familiar planet while we experience a kind of time traveling as sounds of our atmosphere become older and older - until, eventually, we are involved by an oppressive silence and we realize that we traveled further than our oldest sound emission. And when we begin to realize the dimension of our surroundings - that goes much beyond our capacity for abstraction -, we are back to the starting point, returning to Earth through the portal represented by the blue and young eyes of Ellie Arroway, our leading character.
It's like, you know, I'm talking with Drew Barrymore and she is like so drowning me in words, and I'm like so getting it, and I'm thinking like, here is a girl who is like still only 23 years old and has been in like 30 movies and already grown beyond the problems that most people her age still soooo don't know how to handle.


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The process of buying a new BMW car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of BMW car dealerships in and around North Las Vegas, Nevada. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted BMW car dealers in North Las Vegas, saving car buyers time and money on what will be an important purchase.
Non Display Review Name "I'm not your "typical" luxury car person. I am simply a teacher who wanted to drive a nice car. From the moment I walked into BMW of Las Vegas, they m"... Read more Review by: EmilyATeacher
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text: Analysis blog Weapons of disability Preventing deaths and permanent injury needs improved research, monitoring and regulation on crowd-control weapons, says Rohini Haar. Spotlight Can technology build peace? SDGs Citizen science would benefit women Interactive Is Bhutan looking at an energy rich future? Policy Funding gap You are looking at articles about Governance Follow these results: Multimedia: 28/07/16 Debate: What is the future of higher education funding in Africa? Our online debate Thursday 28 July from 1-3pm BST is about the future of higher education, solutions to the … Funding Education Governance News: 27/07/16 Diplomats told to study science and health Training would assist efforts to tackle global challenges related to health and climate change, panel hears. Science diplomacy Policy Capacity building Governance News: 25/07/16 SDGs could boost citizen science in Africa Giving people a say in research will ensure it supports healthy growth on the continent, a conference hears. SDGs Innovation Governance Gender Feature: 25/07/16 Q&A: Leave no scientists behind A report on global progress towards the Sustainable Development Goals promises to be inclusive of all scientists. SDGs Governance Policy Feature: 18/07/16 Q&A: Young African talent will set science agenda Each nation should back its 100 brightest and best, says Cambridge University boss Leszek Borysiewicz. Education Capacity building Policy Governance News: 15/07/16 Climate pledges set to fail Current emissions pledges are too modest to stop world smashing through two degree Celsius cap, a study warns. Climate change Environment Governance Policy Technology Latest on gender Lack of transgender healthcare curbs development Periods are the next frontier of humanitarian response Advance of birth control may boost female smoking Marsh loss shatters lifestyle of Iraq's Ma'dan women Africa Analysis: Science academies are failing women Focus on Private Sector: Smash Arab world glass ceilings View on Gender: Adapt tech to protect female activists Science meets farming to reveal Africa's best bean Q&A: Online training revives Somalia's mental healthcare Culture matters for psychological care Urban women outpace men in growing wealth Pakistan's SDG success hinges on media gender shift Latest on governance from our other editions لنستثمر في تقنيات الإنترنت القادرة على نشر السلام شمال أفريقيا والشرق الاوسط Measuring cause of deaths to help achieve SDGs South East Asia & Pacific Scientists need to communicate well with policymakers Sub-Saharan Africa كي لا تذكي تكنولوجيا الاتصالات الحروب والصراعات شمال أفريقيا والشرق الاوسط Forum calls for linking research to policy and SDGs Sub-Saharan Africa Radar latinoamericano: Juegos con obstáculos América Latina y el Caribe Technology for peace South East Asia & Pacific Can tech tip the balance towards peace? South East Asia & Pacific Tech for peace: Facts and figures South East Asia & Pacific Tech helps but only people can make peace South East Asia & Pacific Spotlight: 13/07/16 Technology for peace Our Spotlight explores the creative uses of communication tools to counter conflict, their promise and limitations. Conflict Governance Enterprise Editorials: 13/07/16 Can tech tip the balance towards peace? Programmes to counter conflict are enlisting digital tools. There are successes, and questions over lasting impact. Conflict Governance Technology Feature: 13/07/16 Tech for peace: Facts and figures Giorgia Scaturro examines how phones, drones, satellites and computer games help spot and prevent conflict. Conflict Governance Opinion: 13/07/16 Tech helps but only people can make peace ICTs can support peacebuilding, but the only way to end conflict is to change minds, says Anahi Ayala Iacucci. Conflict Technology Governance Opinion: 13/07/16 Online connectivity for peace? It's a matter of scale The promise of virtual exchanges is in bridging divides to disrupt a cycle of violence and fear, says Shamil Idriss. Technology Cooperation ICTs Governance Communication Feature: 13/07/16 Simple tools offer path out of conflict Hackathons, crowdsourcing and open data can be potent solutions when resources are limited, says Edd Gent. Conflict Technology Innovation Vulnerability Governance Load more


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We're all well-versed in basic kitchen safety, but there are particular safety precautions you need to know if you're going to spend any time in the kitchen on Friday the 13th. If you plan to cook anything today, take heed of the following warnings:
1. Air bubbles in bread represent coffins, so if you cut into a loaf and see a hole, it's an omen of death. My advice would be to just not cut into any bread today.
2. Spilling your tea means a stranger is coming to visit you.


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Using Picture Storybooks To Teach Literary Devices / Edition 1by Susan Hall
View All Available Formats & Editions
Pub. Date: 09/05/2000
Publisher: ABC-CLIO, Incorporated
Your colleagues have embraced Sue Hall's outstanding volumes as the ideal guides to using picture storybooks to introduce the importance and impact of literary devices in fiction. Why? Because both volumes of Using Picture Storybooks to Teach Literary Devices make it easy to find the perfect book to illustrate a specific literary device. The author has selected nearly 500 picture storybooks that effectively illustrate satire, allusion, pun, imagery, paradox, simile, analogy, and other literary devices. A substantial portion of each volume is a detailed guide for finding appropriate examples. This guide is alphabetically arranged from "Allegory" to "Understatement" and describes the appropriate titles for each device.
Volume 1 covers popular titles published between 1980 and 1988, and Volume 2 covers books published since 1989 as well as classic picture books. All entries include full bibliographic information, a plot summary, examples of the literary device, and other devices used in the book. Entries in Volume 2 indicate appropriateness of a title for older students, the art styles used in illustrations, and suggested curricular tie-ins.
Product Details
- 9780897745826
- Publisher:
- ABC-CLIO, Incorporated
- Publication date:
- 09/05/2000
- Series:
- Using Picture Books to Teach Series
- Edition description:
- New Edition
- Pages:
- 178
- Product dimensions:
- 6.00(w) x 9.00(h) x 0.44(d)
- Age Range:
- 7 - 17 Years
Table of Contents
Literary Devices
Appendix 1: Resources Listed by Author
Appendix 2: Resources Listed by Title
Appendix 3: Resources Grouped by Art Style
Appendix 4: Resources Grouped by Curriculum Tie-In
Appendix 5: All-Ages Resources
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text:
OS X Lion tested with unreleased Intel Core i7 Ivy Bridge chipA modified version of OS X 10.7.3 has been tested with an unreleased Intel Core i7 Ivy Bridge chip, giving a first indication of how Apple's next-generation Macs will perform.
An anonymous tipster provided screenshots of benchmarks conducted with a Core i7-3770K processor to the blog of "tonymacx86." The Core i7 CPU is one of Intel's next-generation Ivy Bridge processors, and was tested at its stock speed of 3.5GHz.
The early test, which used a Z77 motherboard, found that OS X runs well on Intel's forthcoming Ivy Bridge processors. However, while the tests give an idea of how Ivy Bridge will perform with new Macs, the "Hackintosh" benchmarks do not represent any real Apple products.
The person testing the new Intel processor had to modify the boot kernel of OS X 10.7.3 Lion in order to get it to run on the chip. In addition, the Core i7-3770K is a high-end desktop chip that may never find its way into any of Apple's shipping products.
Still, the tests offer the first look at Apple's OS X operating system running on an Ivy Bridge chip. It's also the first glimpse at Intel's HD Graphics 4000, which previous tests running Windows 7 found is 55 percent faster than the 3000 series graphics integrated with the Sandy Bridge processors released by Intel last year.
The "Hackintosh" machine earned an overall Geekbench score of 13,453, led by a score of 20,250 for its processor floating point performance. The tests gauged the quad-core processor with 8 gigabytes of 2400MHz DDR3 RAM.
Apple's new Macs with Ivy Bridge processors are expected to begin debuting in the coming months, starting with new, slimmer 13- and 15-inch MacBook Pros that are rumored to already be in production. The new 15-inch model is expected to be offered in variations powered by Intel's mobile Core i5 and i7 Ivy Bridge CPUs.
AppleInsider reported in February that Apple will conduct a top-to-bottom revamp of its notebooks lineup throughout 2012 that will bring its MacBook Pro portables more in line with the MacBook Air designs. Intel's new Ivy Bridge processors will also feature support for 4K resolutions, allowing Apple to potentially build high-resolution Retina displays for its next-generation Macs.
On Topic: MacBook Pro
- Rumor: Apple to adopt USB Type-C in another upcoming MacBook, whether it's Pro or Air
- Apple pulls legacy non-Retina MacBook Pro from retail store displays
- MacOS Sierra code hints at MacBook Pro touch bar, Touch ID integration
- Apple preparing changes to MacBook lineup this month
- MacBook Pro with OLED touchbar visualized in new concept renderings


text:
- Miss Florida 2017 stripped of crown days after win - US Weekly
- Lindsay Lohan steps out amid relationship drama - TMZ
- Was Taylor Swift snubbed by the VMAs? - Gossip Cop
- Rachel Platten sings "Fight Song" with lots of stars - Just Jared Jr
- Farrah Abraham sizzles in a revealing bikini - Radar
- New pics from the Clooneys' Italian summer - Lainey Gossip
- Fox News snubs major DNC moment - The Hollywood Reporter
25 June 2014 at 1:17 PM
Lindsay Lohan Changes Up Her Look to Some Party Wear for Night Out!
About this photo set: Lindsay Lohan changes into some party wear as she heads out to hit up Loulou's on Tuesday evening (June 24) in London, England. That same day, the 27-year-old… Read More Here
Photo #: 3143022
Posted to Lindsay Lohan
powered by ZergNet


text:
Country Church
While leaf peeping through New England, one of our objectives was to photograph a country church with a rich automun color background. After spending two weeks in the area, we found this photo on our way home.
Photographer: Penny & Dennis Wayne
Location: Orland, ME US
Updated Saturday, November 6th, 2004
You May Like
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- By Category: Churches


text:
Suncoast Makers Message Board › New Meetup: Fab Lab is open to the public- list of classes going on for the day.
|A former member
Announcing a new Meetup for Sarasota Makerspace!
What: Fab Lab is open to the public- list of classes going on for the day.
When: Saturday, May 7, 2011 7:00 PM
Where: (A location has not been chosen yet.)
Why: Safety & Orientation Training - 1-3PM (free) Hand Tool Basics - 3:30-4:30 PM (10$) Safety & Orientation Training - 6-8PM (free) We are ready & open for your projects! All hobbyists and interested visitors welcome.
Please tell your friends about the Fab Lab.
Check it out!
|A former member
"I just filled up the May calendar with our scheduled classes. The Safety training is mandatory to use the machines, and there are manuals and helpful people at the Fab Lab at all times. I also added a bunch of photos. -Allison"
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