text:
Really nice and good quality!
great find
great find got them for a friend with the matching necklace she wears often
I guess I set my expectations for these earrings based on a price and was very dissapointed receiving cheap looking and made. Metal looks like brass , stones like plastic. To my opinion this product is way overpriced.
- How did the image on site compare with the actual product? accurate
- How accurate was the sizing? accurate
- Please tell us about the quality of the product. average
Sort Reviews By:
People who bought this also bought


text:
At least this band delivers on the promise of its name. From the opening track, "Battle of the Rabbits," you feel as though you've time-warped back to a fictional past when the club Tech Noir wished it could play music this frenetic. If Mr. Pacman fronted the Nails and ditched the horns, you'd get something like this: Fuzzy, relentless bass to match the strong if spare drumming and urgent yet equally minimal synth work behind barely clipped vocals make everything sound slightly tongue-in-cheek. Revisiting early-'80s new wave has rarely been this lively and curiously devoid of kitsch since the Faint put out Danse Macabre. If anything, Pep*Squad sounds as though it's trying to awaken the latent dance moves in its audience through sheer enthusiasm.
Get the Music Newsletter
Keep your thumb on the local music scene each week with music news, trends, artist interviews and concert listings. We'll also send you special ticket offers and music deals.
In Case You Missed It
Upcoming Events
Jason Boland & the Stragglers
TicketsThu., Jul. 28, 8:00pm
Stumble Monkey
TicketsFri., Jul. 29, 8:00pm
The Black Lillies
TicketsSat., Jul. 30, 8:00pm
Jeff Beck With Buddy Guy
TicketsSun., Aug. 7, 7:30pmpowered by goldstar
Popular Stories
Sponsor Content

subset: commoncrawl


text:
Return to SwingLifeStyle.com The Swingers Home Page
There are a total of 16245 Austin Corners swingers, within 100 miles.
The list below is a subset of the swingers in the Austin Corners area.
Create a free swingers account so you can see and write to them all.
***red***Ladies, fuck my husband please***/red***
Who wants to play
Just looking to enjoy life
Love to eat chocolate
Need a new tag line....
....n' then I heard her say, "I'm getting wet"....so I peeked, can I get a "whoop-whoop"....;)
This is all new to us, we are ready to explore!
Almost not a newby
we googled swingset, and ended up here. We didn't need that dumb thing anyway.
fun loving couple seeks friends
Finally summer! Time to swim and ride.
Lookin for some new friends.
It's gettin' hot in here
Not looking at the moment... But you can email! Ya never know my mood! ;)
let's have fun
Looking for people looking for no drama fun
Lets have FUNN
Chat us? K ik Timplaysdrums hit us up
Just how long can you stay "the new couple"?
Active Swingers as of 26-Jul-16.
This site does not contain sexually explicit images as defined in 18 U.S.C. 2256.
Accordingly, neither this site nor the contents contained herein are covered by the record-keeping provisions of 18 USC 2257(a)-(c).
Disclaimer: This website contains adult material. You must be over 18 to enter or 21 were applicable by law.
All Members are over 18 years of age.
Terms of Use Privacy Policy


text:
On ESPN' Mike & Mike in the Morning on Wednesday, North Carolina coach Roy Williams reiterated that he doesn't expect point guard Kendall Marshall -- who is in a cast up to his elbow after surgery on his fractured right wrist Monday -- to play on Friday in the NCAA Regional semifinals.
"What we're going to do is just practice every day, and if something weird happens that they say he can play, I'm probably going to let the guy play. But I just do not foresee that happening," Williams told the radio show.
Marshall's injury, suffered Sunday, will take eight to 12 weeks to completely heal, the coach said. But the team has not completely ruled out the possibility of the sophomore playing when the top-seeded Tar Heels play No. 13 seed Ohio in St. Louis.
Williams said again that freshman Stilman White (4.2 mpg) and senior Justin Watts (a wing who has served two stints at ballhandler this season) will fill in at point guard.
"One thing I'm trying to get them to understand is, you can help us by not hurting us,'' Williams said. "Don't try to be Kendall Marshall; be what you are. Secure the basketball, don't put the ball in jeopardy, and move the ball up the floor as quick as you can by dribble or pass. Make the easiest play.
"… I think it will kind of be like a quarterback in football: 'We've got other good players, don't you try to be the dominating factor in the game; get the ball to those other guys and let them make plays."
The coach also said he doesn't think he will use small forward Harrison Barnes to run the offense, "but I do think we'll ask him to be more aggressive, to be more of a scorer. … We're saying, 'It doesn't have to be one guy, it has to be everybody.'"
Click here for Williams' full podcast on the Mike & Mike show....
Follow Robbi Pickeral on Twitter at @bylinerp.


text:
If we take a typical open set in the lower limit topology [a,b), how can its complement be closed when the definition of a closed set is one that contains all of its limit points. In this case the missing limit point is a.
Recall that given a topological space $X$, an $A \subseteq X$ and $x \in A$, we say that $x$ is a limit point of $A$ (in $X$) if every open neighbourhood of $x$ (in $X$) meets $A$.
As such, being a limit point of a set is wholly dependent on the underlying topology you are currently using/interested in. While $a$ is a limit point of $A =( - \infty , a ) \cup [ b , + \infty )$ in the usual metric topology on $\mathbb{R}$, this need not be true when you use a different topology. For instance, the set $[a,b)$ is an open neighbourhood of $a$ in the lower limit topology — it is an open set in the lower limit topology which contains $a$ — which is disjoint from $A$, and so $a$ cannot be a limit point of $A$ in the lower limit topology.


text:
Ransomware attacks -- where online extortionists encrypt data on a victim's computer and then demand a fee for unlocking it -- started off mainly as a consumer problem but increasingly is hitting businesses and government entities as well.
The trend has significantly heightened the need for organizations to have measures in place for blocking the threat and for mitigating damage to the extent possible. Most security experts agree that it is almost impossible to recover data that might have been encrypted in a ransomware attack without access to the decryption keys, or to a backup copy of the affected data.
So the focus has to be on prevention.
"[Ransomware] is evil because if implemented correctly by the attackers … it is very difficult to recover the data on the machine," says Engin Kirda, co-founder and chief architect at security vendor Lastline. "The key difference of this type of malware compared to traditional malware is that you often know that you have been infected because the malware tells you this."
Having a robust data backup process can go a long way in blunting the threat posed by ransomware. In fact, it is often the only way to recover data if you are unwilling to pay the ransom demanded by an extortionist. But there are other measures that organizations can take as well, including the following:
Authenticate In-Bound Email
Email is a commonly used method to distribute ransomware. Attackers target victims with cleverly spoofed emails that appear to originate from someone the victim knows. The emails have malicious attachments which when opened results in the ransomware being downloaded on the victim's system.
One of the most effective ways for an organization to blunt this threat is to validate the origin of an email before it is delivered to the intended recipient, says Craig Spiezle, executive director and president of the Online Trust Alliance (OTA).
Implementing sender identity technologies like Sender Policy Framework (SPF), Domain Message Authentication Reporting and Conformance (DMARC), and DomainKeys Identified Mail (DKIM) can all protect organizations against spear phishing, business email compromise, and other threats posed by spoofed email, Spiezle says. They work by validating the IP address and domain of the server from which an email originates.
"Unfortunately, most corporations are not authenticating inbound mail," Spiezle says. And when they do, the policies are not strong enough. For example, emails that fail authentication tests are often simply quarantined or sent to a junk folder. Instead, "corporations that have sensitive information should have a reject policy for email that fail," authentication tests, he says.
Protect Your Email Servers
Sender authentication can mitigate the risk of ransomware being delivered via email. But that alone is not sufficient, says Craig Young, security researcher at Tripwire. If you haven't done so already, protect mail servers by scanning all stored, incoming, and outgoing mail. Such scanning can help organizations detect threats that might have evaded perimeter defenses or infiltrated the network via compromised systems and internal email. Numerous tools are available for scanning email servers for security threats. Take advantage of them, he says.
"Email authentication is a good measure to have," Young says. "But there's always a chance that a legitimate email server is used to send out spam emails," and other malware, he says.
Add Ad Blocking
In addition to emails, attackers often distribute ransomware through malicious advertisements served up to users when they visit certain sites. Malvertisements allow attackers to target victims based on their browsing habits, location, demographic information, device characteristics, and other criteria. Ransomware served up via watering-hole attacks often tend to be more dangerous than random attacks because they are targeted at victims which the attackers know have the capability to pay up.
Blocking ads from being delivered on user systems or preventing users from accessing certain sites can diminish this risk somewhat, Spiezle says. Organizations that want to accommodate unrestricted access to the Internet for employees might consider implementing a separate network for them to do so, he says, pointing to one government contractor that has taken this approach.
Monitor File Activity
With ransomware, an attack against an individual can quickly escalate into an attack against the enterprise, says Amichai Shulman, chief technology officer at Imperva. Many ransomware tools have the ability to encrypt not just the hard drive of a system, but also any shared files.
In fact, rapid file overwriting is one of the clearest markers of ransomware on your network, he says. So using a tool to monitor file activity is a good idea, says Shulman, whose company sells an activity-monitoring tool.
"If you are constantly monitoring access to file servers, there are very distinctive patterns that you can look for in order to detect ransomware," on an endpoint, he says.
Such early detection can help organizations contain the damage that a ransomware tool can wreak, he says. "The advantage is that you can go quickly into quarantine mode for the infected machine and make sure it doesn't connect to any other file server," in the enterprise.
Keep Your Response Plan Handy
Time is critical for an organization faced with a ransomware deadline. Online extortionists typically give organizations a very specific time limit within which to pay -- fter which they sharply increase the ransom amount. Attackers have gotten increasingly better at knowing what an organization can afford and knowing exactly when to strike, Spiezle says. They deliberately don't give enough time for an organization to figure out if it can try and unlock the data without paying any ransom.
So it is important to have a plan in place describing what needs to happen in the event of a ransomware attack. Do an inventory of your critical data assets, know where it is located, and evaluate that impact of any loss or unavailability of that data.
"One of the worst things is the chaos that ensues during an incident like this. Emotions run high, people don't have the answers and they are scrambling," to respond. he says. "The last thing you want is to be doing a Google search for a local forensics experts at 2am on a Saturday morning."
Related Content:
Find out more at Interop 2016, May 2-6, at the Mandalay Bay Convention Center, Las Vegas. Register today and receive an early bird discount of $200.Jai Vijayan is a seasoned technology reporter with over 20 years of experience in IT trade journalism. He was most recently a Senior Editor at Computerworld, where he covered information security and data privacy issues for the publication. Over the course of his 20-year ... View Full Bio
The cybersecurity profession struggles to retain women (figures range from 10 to 20 percent). It's particularly worrisome for an industry with a rapidly growing number of vacant positions.
So why does the shortage of women continue to be worse in security than in other IT sectors? How can men in infosec be better allies for women; and how can women be better allies for one another? What is the industry doing to fix the problem -- what's working, and what isn't?
Is this really a problem at all? Are the low numbers simply an indication that women do not want to be in cybersecurity, and is it possible that more women will never want to be in cybersecurity? How many women would we need to see in the industry to declare success?
Join Dark Reading senior editor Sara Peters and guests Angela Knox of Cloudmark, Barrett Sellers of Arbor Networks, Regina Wallace-Jones of Facebook, Steve Christey Coley of MITRE, and Chris Roosenraad of M3AAWG on Wednesday, July 13 at 1 p.m. Eastern Time to discuss all this and more.


text:
Quick Tip: How to Disconnect Your iOS 9 Device From a Bluetooth Accessory
iOS 9 makes it much easier to switch which iOS device is connected to a single Bluetooth accessory. Here's how to temporarily disconnect your iPhone from a device.
iOS 9 makes it much easier to switch which iOS device is connected to a single Bluetooth accessory. Here's how to temporarily disconnect your iPhone from a device.
Flexbits has updated it popular Fantastical 2 apps for the iPhone, iPad and Apple Watch to version 2.5.
The iBlazr 2 Flash Bundle will give your everyday photography a professional edge by letting you take amazing photos in low-light situations.
The Flash returns on the CW next week, and to celebrate, we found a sharp Flash cowl logo to use as a wallpaper on your iPhone, iPad, or Mac.
SCOSCHE later today will announce the release of the goBAT 6000 Rugged Portable Backup Battery, an "indestructible" portable battery pack designed to withstand and perform in the elements.
As of the games played today, Major League Baseball will begin allowing an iPad in the dugout during games. The tablets can only be used for such tasks as checking charts, statistics, and scouting reports.
If you're a current iPad user who makes use of the free features of Microsoft's Office suite of apps and will be moving up to the iPad Pro when it is released, you'll be disappointed to find out Microsoft will require an Office 365 subscription to use the apps on the larger tablet.
T-Mobile is offering pre-orders on LTE-enabled models of the new iPad mini 4, priced at the usual $529 for a 16GB model. "Well-qualified buyers" can get the device for $0 down + $22.08 per month. Financing is at 0% APR.
Apple has updated iMovie, their iOS video editing app, to add several new features that will be compatible with the upcoming iPhone 6s, iPhone 6s Plus, and iPad Pro. The new features include support for 3D Touch, and for editing 4K video.
The three subscribers of the EPIX movie channel will be happy to know that the premium cable network will soon allow users to download a number of movies and television shows to their iPhones and iPads.
If you're looking for the perfect-sized MFi Lightning cable to carry around with you during your busy day, the "fun-sized" Titan Loop MFi-Certified Lightning Cable is the cable for you!
The Apple-supplied Xcode development tool indicates the iPhone 6s and iPhone 6s Plus will sport 2GB of RAM, while the iPad Pro will boast 4GB of RAM.
A few anointed members of the media got a chance to spend some hands-on time with Apple's new iPad Pro, and we've shared a sampling of opinions about the new tablet from around the net.
Apple won't be the only company offering keyboards for their new 12.9-inch iPad Pro, as Logitech has already announced their own Logitech CREATE Keyboard.
A press release for Adobe's Photoshop Fix app, demonstrated on the iPad Pro at Wednesday's Apple event, indicates the A9X chip in the iPad Pro has a healthy 4GB of RAM installed, double that of the iPad Air 2!
The much-rumored iPad Pro was unveiled at today's big Apple event, and the huge new tablet is impressive to say the least. The 12.9-inch device boasts a Retina display with 5.6 million pixels, and is powered by a new A9X chip.


text:
Effect of Lipid Physical State of Palm Derivatives on β-Carotene Bleaching
Version of Record online: 11 MAR 2013
© 2013 Institute of Food Technologists®
Journal of Food Science
Volume 78, Issue 4, pages E549–E554, April 2013
Additional Information
How to Cite
Calligaris, S., Manzocco, L., Da Pieve, S., Arrighetti, G. and Cristina Nicoli, M. (2013), Effect of Lipid Physical State of Palm Derivatives on β-Carotene Bleaching. Journal of Food Science, 78: E549–E554. doi: 10.1111/1750-3841.12087
Publication History
- Issue online: 5 APR 2013
- Version of Record online: 11 MAR 2013
- Manuscript Accepted: 23 JAN 2013
- Manuscript Received: 3 DEC 2012
- Abstract
- Article
- References
- Cited By
- β-carotene;
- lipid crystals;
- stability;
- structure
This research was addressed to study the effect of lipid physical state on bleaching kinetics of β-carotene. To this aim, β-carotene was added to palm oil and palm stearin and the samples were stored at increasing temperatures allowing different degree of crystallization. Phase transition properties of palm derivatives were studied by differential scanning calorimetry and synchrotron X-ray diffraction, whereas β-carotene bleaching kinetics were followed by measuring color changes. Bleaching proceeded at comparable rate in palm oil and palm stearin containing systems stored at 20 and −18 °C, whereas the color changes showed a maximum rate at 4 °C in palm stearin samples and at −7 °C in palm oil systems. Arrhenius plot clearly highlighted deviations from the linearity underlining the crucial role of lipid physical properties in determining the bleaching rate. The location and the compartmentalization of β-carotene in the fat lattice could affect its chemical stability.
Practical Application
β-carotene stability is greatly affected by the physical state of the lipid carrier. The latter should be carefully designed in the attempt to protect β-carotene from bleaching.


text:
© 2016 Need Supply CompanyAll Rights Reserved
Sign up to get notified when this product is back in stock
Free Shipping Free Returns
Orders Over $75 See Details
Black fishing hook on a thin adjustable corded leather from MIANSAI.
24" length
View Size Chart
View Size Chart
3100 West Cary Street
Richmond, VA 23221
© 2016 Need Supply Company—All Rights Reserved
Sign up for our newsletter and get 10% off your next order. Pretty sweet, we know.


text:
Related Regions:
North America,
United States
33 Resort Reviews
Write New Review
Having lived elsewhere in the Midwest, including Wausau, WI (home of Granite Peak/Rib Mountain), Welch was a welcome discovery. This will be my second year purchasing a season pass for the mid-continent bump. I have skied Afton and almost always got either run over by, or run over a "moving bump", a.k.a. out of control kid. The mob scenes there on the weekends drive me nuts. This is what motivates me to drive over an hour to Welch. I appreciate a number of things about the hill.
1. Varied terrain.
Welch offers a variety of terrain for all skiers and snow boarders. There are a NUMBER of runs for each level as well. The steeps are steeper and the rollers are longer than other area hills. Most runs are reasonable in width allowing for easy turns and technical skiing, but there are some narrower runs for a different ride.
2. Friendly Staff.
I know Minnesota likes to talk about "Minnesota Nice", but not all hills have the nicest people working there. I have been impressed with the staff at Welch. The Ticket folks are welcoming, the office staff is friendly, and the bar tenders at Madd Jax actually remembers your drinks after you have come in a few times during the season! Lifties also know how to position the chair so that it doesn't smack you in the calves like the Afton chairs do.
3. Investment.
This is the only hill that I am aware of that is continuing to invest heavily in its operations. Last summer they doubled snow making capacity. This was evident when they opened earlier than I can remember a Midwest hill opening in years. This summer, they added an entirely new area to the hill. They are calling it the "Back Bowl". I am calling it "No loitering!". This area only has <> runs and opens in December to season pass holders. If you look at new trail maps, you will see a third lodge planned for the flats at the top of the East side of the hill. Welch may not have the most lavish lodge right now (although it does not feel nearly as dated as others in the twin cities), but that's not the main reason any serious skier selects a hill.
4. Location.
Yes, it is one of the farthest hills from the city. I consider this a good thing and a bad thing. Great because it keeps the "Let's load up a bus of kids and send them to the ski hill" crowd away. It also keeps the "Drop the kids off and let the lifties baby sit for the day" crowd away. Those are the kids that usually trash a lodge, cut lines, ride out of control, and generally make a bad day of things for others. The location has other benefits as well. The area around Welch is beautiful. Views are always scenic and you aren't skiing on an open faced hill. Also, Red Wing has some great shops if you want to make a weekend out of it and the Casino is only 20 minutes away. It is a great way to take a weekend away, but only on a few gallons of gas.
5. Boarders Welcome...
...But not at the expense of everyone else. I enjoy watching snow boarders in terrain parks. I can't do what they do, nor can I do what the trick skiers do. I also like to ski all areas of the mountain. A comment posted earlier states that carving is banned. I don't remember reading that anywhere, seeing it posted anywhere, or hearing it from anyone. My guess is that the person making that comment was skiing either out of control or disrespectfully of others. I would prefer boarders who carve. They tend to keep the snow on the hill as opposed to those who just "push" the snow to the bottom like a tiny little snow plow. The park is one area I think there may be improvement. I don't use the jumps, but I know what a good park looks like. Last season though, there were some decent sized jumps that were well spaced out, my guess was to ensure a proper landing zone below. I do hope the terrain park is more substantial this year! I enjoy taking a break and watching the people fly.
I have been reading the other reviews of Welch and have to ask if they visited more than one day. Every hill has its good and bad days. I've skied Afton on the worst days with crapy conditions as well, but my review won't be based on that one ride. It will be based on having been there numerous times over a few years. Likewise, my review of Welch is based on three years of regular visits, talking to people who drive up from Iowa just to ski Welch, and critiques from Mountain Veterans who rank the hill high in its class.
To anyone who has never been there, TRY IT OUT! Make sure you go knowing what conditions to expect based on recent weather, and try to get first tracks after they do a night grooming. I would bet you will have the same quality experience I did. Hope to see you all on the hill!
P.S. Insider tip, if you have your own skis and like to gear up at your car, park by Madd Jax and buy your ticket there.
Click to collapse
Search for resorts in:
Click the map to add a state to your resort search
Click to add Colorado


text:
Mass Shooting At Oregon Community College, At Least 13 Dead
CREDIT: Screenshot
A mass shooting at Umpqua Community College has left at least 13 people dead and 20 injured.
UPDATE: 13 dead in #UCCShooting according to OR Attorney General https://t.co/MsDrfyQ6oM
— KGW News (@KGWNews) October 1, 2015
The shooter is among the dead, CBS reported. The 911 calls after the shooting began around 10:30 Pacific time said that the gunman went down after 11 minutes. The Douglas County Sheriff, John Hanlin, said the gunman shot at police near some classrooms. The gunman has not yet been identified but Gov. Kate Brown said the shooter was a 20-year-old man.
Shooter among the dead, CBS reports, citing Oregon attorney general https://t.co/CzNl3DVsqD
— KVAL News (@KVALnews) October 1, 2015
Kortney Moore, an 18-year-old student, told the Oregon News Review that she saw her teacher shot in the head after the gunman burst into her writing classroom. He then told students to state their religion and started firing at random, she said.
Students say they were locked down in the library. Once the active threat was over, they were bussed off campus to the Douglas County fairgrounds, where counselors are waiting to talk to students, families and staff.
President Obama has been briefed and is receiving updates from Homeland Security as the situation develops. The FBI and ATF have sent agents across the state to investigate. Former Attorney General Eric Holder weighed in on the shooting as well, calling for more
"Now Oregon."
U.S. Attorney General Eric Holder comments on #UCCShooting and gun violence in the United States: pic.twitter.com/ddZ3FQUn36
— AJ+ (@ajplus) October 1, 2015
The Oregonian reported that Roseburg, where UCC is located, is no stranger to school shootings. A Roseburg High School student shot a fellow student in the school courtyard in 2006, prompting UCC and other schools to develop active shooter plans.
This is the 45th shooting at a school in 2015 and the 142nd shooting since the massacre at Sandy Hook Elementary School in Newtown, Connecticut.
This post will be updated as more information becomes available.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jul 9, 2002
|Filing date
|Dec 15, 1998
|Priority date
|Jan 23, 1997
|Fee status
|Publication number
|James Maioriello, Jairo Rene Martinez, James A. Hayward
|Original Assignee
|Collaborative Laboratories, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (5), Referenced by (2), Classifications (12), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a division of application Ser. No. 08/787,686, filed Jan. 23, 1997, now abandoned. This prior application is hereby incorporated herein by reference, in its entirety.
The present invention relates to dramatization, and, more particularly relates to a process for reacting a water soluble polymer with a water insoluble derivation agent and product by same.
Terms such as suspension polymerization and interracial polymerization are known to be used to describe processes by which polymers are synthesized by cross-linking of their mongers utilizing a polymerizing agent. Polymerization is known to occur within such processes heterogeneously, where the mongers, which are usually water insoluble, form tiny droplets which act as a reservoir of react ants. In some instances, surfactants may be added to facilitate droplet formation and stabilization.
The polymerization initiator or polymerizing agent may be either water soluble or water insoluble. In the case where the polymerization initiator is water-insoluble, polymerization occurs within the monomer droplet to form latex's (suspension polymerization). When water soluble polymerization initiators are employed, polymerization occurs within micelles formed from the added surfactants (emulsion polymerization). Interracial polymerization describes a process whereby polymers are formed at the interface of two immiscible liquids, each containing a reacting monomer in solution. Each of the mentioned processes, suspension, emulsion and interracial polymerization, are polymerization processes wherein the polymer is prepared at the interface of immiscible liquids.
Dramatization is a term used to describe a process whereby functional groups pendant to a polymer chain are chemically modified or reacted in some way to change some character of the polymer. Typically, this is facilitated in solvents which are capable of dissolving the polymer and the derivation agent. Solvents are necessary because such reactions do not occur unless the reacting species (i.e., the polymer and derivation agent) can be brought into intimate contact. For that matter, a common or miscible solvent is almost always used in prior art polymer dramatization processes. Alternatively, phase transfer catalysts may be utilized to react polymers and derivation agents in certain instances, but the phase transfer catalysts are costly and of limited general utility.
Those skilled in the art are continuously looking to uncover or create new polymers, particularly in the fields of biochemistry. For that matter, great interest has recently been shown in a biopolymer known as hyaluronic acid (HA) for its usefulness in a variety of personal and health care products. Hyaluronic acid is a member of a broad class of naturally occurring polyanionic carbohydrates collectively known as glycosaminoglycans (GAGs). Hyaluronic acid consists of repeating units of the of N-acetyl-D-glucosamine and D-glucuronic acid (its primary structure), joined by a β1-4 glucosaminic bond (FIG. 1). The molecular weight reported for hyaluronic acid varies between 50,000 to 80,000,000 Daltons depending on the source, method of isolating and method of size determination.
Hyaluronic acid is also a biomolecule which is naturally present in connective tissue, synovial fluid, adult human skin, etc., HA functions as a biomolecule to impart structure and rigidity to the tissue or biomaterials within which it is present. Accordingly, HA is biocompatible such that HA and HA derivatives introduced systemically are normally well accepted by the human body. Hyaluronic acid is also believed to regulate cell morphology and to protect organisms from bacterial and/or other external factors. This protective action is believed related to HA's high viscosity and water solubility. HA's high viscosity is attributed to the extensive hydrogen bonded network present in its carboxylate form, which also facilitates the formation of highly viscous HA gels, or hydrogels.
Many novel HA-based products are known and available in the marketplace which utilize HA's unique biocompatibility. For example, Biocare Polymer HA-24, Biocare AS, Visible Youth, Hylaform, Healon, Synvisc, Seprfilm, and Sepragel, are merely several known HA-containing products available in the US and world markets. Such products have a broad range of applications such as opthalmics, wound repair, surgical aids, cosmetic moisturizers, etc., as well as the development of bioerodable scaffolding for tissue engineering, and regeneration.
HA, therefore, is an extremely important molecule (i.e., biopolymer), applications for which may be improved by its dramatization. For example, attachment to HA of a compatible molecule could further enhance the biofunction facilitated by the HA-based product, or provide for a function in addition to that provided by the HA. Hence, it would be desirable to develop a process for derivation polymeric moieties, such as HA, in a safe and efficacious manner to realize desired polymeric entities with improved functional properties.
In this invention, we describe a process whereby polymers present within a solution may be derivative by a derivation agent therein which is ordinarily insoluble in the solvent. Preferably, the solvent is water and the polymer is water soluble. The water and the water soluble polymer are mixed with the water-insoluble derivation agent, and the mixture is emulsified using a Polytron™ homogenizer. The homogenizer action renders the water insoluble derivation agent within the mixture into the form of tiny droplets, typically less than 1 micron in diameter. To facilitate emulsification, the derivation agent is preferably a liquid, or, in some instances, a highly concentrated solution in a suitable water-insoluble solvent. The polymer is compelled to undergo dramatization at the interface between the aqueous phase and the emulsified derivation agent. Hence, the process is referred to as interracial dramatization.
The process of the present invention is useful for several reasons. First, by utilizing the process described herein, it is possible to react a polymer with an agent where the react ants normally do not react because their wide differences in solubilities prevent the intimate contact necessary for reaction. The second reason is that the process is an alternative process to the more costly emulsion polymerization processes known in the art. The (cost of the additives needed for emulsion polymerization excessively increases the cost of the process since it may be necessary to remove the additive in a subsequent process. Finally, the use of additives while facilitating the chemistry, may alter the resulting product in some deleterious way. For example, surfactants can act as placticizers to a polymer altering the polymer's physical properties.
Accordingly, a preferred embodiment of the enabling technology is presented herein in the form of a dramatization process utilizing hyaluronic acid (HA), a water soluble biopolymer. It should be noted, however, that while specifically describing HA dramatization, the invention is not limited to the interracial dramatization of HA, or any other water-soluble polymer. The interracial dramatization process defined herein is applicable to any water-soluble polymer containing carboxyl and/or hydroxyl groups, or more generally, other water-soluble polymers containing nucleophilic groups. Accordingly, the scope of the invention should be limited only by the claims appended hereto.
FIG. 1 is a schematic representation of hyaluronic acid; and
FIG. 2 is a schematic representation of the results of a proton NMR spectroscopy of adipic dihydrazide derivative of hyaluronic acid prepared in accordance with the process of this invention.
The present invention discloses a process for derivation HA to varying degrees for applications within the pharmaceutical, health and personal care industries. The process recited is referred to as interracial dramatization. Within the interracial dramatization process, a water-insoluble chemical moiety or derivation agent is attached to a water-soluble polymer. The conjugation of the moiety to the polymer occurs at or near the interface of the two phases, formed as a mixture for reaction. That is, between the aqueous phase comprising the polymer and the water-insoluble phase comprising the water-insoluble derivation agent. The aqueous phase may include a water-soluble derivation agent whereby an activating agent which essentially readies the water-soluble polymer for dramatization is contained in the non-aqueous phase. Therefore, during the homogenizing mixing, the water-soluble polymer and water-soluble derivation agent are brought into contact at the interface of the aqueous phase to that of a non-aqueous phase containing the water-insoluble activating agent. Alternatively, the activating agent may be contained in the aqueous phase and the derivation agent may be in the non-aqueous phase.
For example, a process of the invention utilizes dicyclohexyl carbodiimide (DCC) as an activating agent in a non-aqueous phase. The water-soluble polymer and the derivation agent are maintained in an aqueous phase. DCC is a water insoluble carbodiimide, which are known to react with carboxylate groups to form "activated carboxylates" [Recent Developments in the Carbodiimide Chemistry, Marian Mikolojczky, and Piotr Kielbasinski, in Tetrahedron, 1981, 37, 233-284]. DCC is commonly used to activate carboxylate groups of a polymer for dramatization of same to form new polymer entities. That is, the carboxylate group is activated and then reacted with a derivation agent or other portion of the polymer. Without activation, the polymer would not be capable of reaction (i.e., conjugation with the added derivation agent) since both the polymer and the derivation agent are of the same electronic functional group class (i.e., nucleophiles). Hence, the necessity to "activate" the functional group at the interface between the phases to facilitate the dramatization reaction.
While water soluble carbodiimides do exist and can be used to activate carboxylate-containing water soluble polymers in the presence of a water soluble derivation agent, they are very expensive and cost prohibitive in some applications. Accordingly, the present invention utilizes DCC as a water-insoluble activating agent which is significantly less expensive than prior art agents which could be used to derivative the same polymers. While the examples cited herein apply to the dramatization of hyaluronic acid, a water soluble polymer containing carboxylate and hydroxyl groups, the technology could be used to make derivatives of other polymers which contain carboxylate and hydroxyl groups using the less costly and readily available DCC as the carbodiimide.
However, the invention also supports process whereby both the water-soluble polymer and the activating agent are in the same aqueous phase, and the water-insoluble derivation agent is in non-aqueous phase. In such a case, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is utilized within the aqueous phase as the activating agent. Hence, cost is not an issue but the process is amenable to dramatization of a water-soluble polymer with a water insoluble derivation agent, such as palmitic hydrazide.
In a preferred embodiment, the process of this invention includes forming a reaction mixture as an emulsion using a homogenizer. Essentially, a water-soluble polymer and water-soluble derivation agent are first dissolved in aqueous solution. The water-insoluble activating agent is added for emulsification into the mixture by the homogenizer. The water soluble polymer and derivation agent are mixed while the mixture is maintained as a dispersion within a proper range of pH. When the dispersion's pH is observed to be stable, a non-aqueous phase containing the activating agent is added to same. The mechanical action of the homogenizer creates contact at the interface between the phases.
Alternatively, the activating agent may be water soluble and therefore maintained in the same aqueous phase with the water-soluble polymer to be derivative, whereby the derivation agent is maintained in non-aqueous phase. EDC is appropriate under such circumstances. It follows that the water-soluble polymer is activated by the EDC within the polymer/EDC dispersion. The activated polymer is derivative in a subsequent step emulsifying the aqueous phase with the derivation agent. The activated polymer can be isolated in pure form by removing from it unwanted byproducts, such as unreacted carbodiimide, and then lyophilizing the resulting purified polymer before mixing it with the non-aqueous phase which includes the derivation agent. Because the actual derivitization occurs at the interface between two phases, we define or characterize the process of this invention as interracial dramatization. That is, interracial derivitization is a process by which a polymer is derivative at the interface between a bulk aqueous phase and an oil-soluble phase. The aqueous phase may include the derivation agent where the activating agent is maintained in the water-insoluble phase. Alternatively, the aqueous phase may contain the activating agent whereby the derivation agent is maintained in non-aqueous phase.
Through emulsification, the effective surface area of the insoluble derivation agent is increased to a point where the reaction rate is convenient for development of commercially viable processes. For that matter, while the process is described with particular reference to HA, it can be utilized to derivative a wide range of soluble polymers with insoluble agents provided the chemistry is correct. A Polytron� mixer, as mentioned above, is a preferred homogenizer. Polytrons are generally used to disrupt plant and animal tissues for the purpose of obtaining their intracellular components. Polytrons are also used to prepare emulsions by imparting energy to mixtures of water and oil to render the oil in a form of tiny droplets (less than 1 micron in diameter as an emulsion). Other types of homogenizers can be used by the process described herein without diverging from the invention's intended scope. For example, a Silverson Mixer has been used to emulsify oil into water.
The following example describes the process for preparing an adipic dihydrazide derivative HA polymer. All reagents and chemicals used in this or following examples are available from commercial suppliers, except HA-QUAT, which is prepared in applicant's laboratories by reacting HA with N-(3-chloro-2-hydroxypropyl) trimethylammonium chloride.
Approximately 10.0 g of hyaluronic acid (manufactured and supplied by ARD, France, MW 0.7 MD) were dissolved in 2.00 L H2O in a 4-L beaker. The solution was heated slowly to 43� C. while stirring with a Silverson L4R mixer at 5000 rpm. Afterwards, approximately 10.6 g of adipic dihydrazide (ADH) were added and the mixture was stirred until it was observed to be homogeneous. Adipic dihydrazide is capable of reacting with polymers containing carboxylate groups which have been activated using carbodiimides. The result is a hydrazide of the polymer. The HA's carboxylate group is activated with the carbodiimide to form an O-acyl urea derivative ("activated carboxylate group"), which is then caused by the emulsification to react at the interface of the phase containing the adipic dihydrazide to form the resulting polymer hydrazide in the same process.
The carboxylate group is activated with the carbodiimide to form an O-acyl urea derivative ("activated carboxylate group"). The pH of this aqueous phase is then lowered to within a range of from about 4.2 to about 4.85 by the addition of 1 N HCl. When the pH of the reaction mixture has been adjusted, approximately 1.3 g of molten dicyclohexyl carbodiimide were added to the dispersion while operating the mixer's speed at between 3500 and 3600 rpm to maintain the mixture in an emulsified state. The phase containing the molten DCC interacts at the interface with the ADH and HA to activate the HA for dramatization by HA. The pH was maintained between 4.2 and 4.85 by addition of 1 N HCl while stirring continuously as described. The pH of the reaction mixture containing the ADH-derivative HA was observed to be constant for approximately 20 minutes after approximately 1.75 hours stirring and adjusting, and then neutralized by the addition of 6 N NaOH.
The neutralized ADH derivative HA mixture was allowed to cool to room temperature and purified by continuously circulating it for two days through a Minitan� system, manufactured by Millipore Corporation of Massachusetts, at 10 psi, using a 300,000 MWCO polysulfone membrane. Purification removed lower molecular weight starting material and reactivity byproducts. The purified retentate was freeze-dried to afford solid HA-ADH or hyaluronic acid derivative with adipic dihydrazide. Results from elemental analysis of the freeze dried product were as follows: 40.66% C, 6.48% H, 4.51% N. Using the calculated dependence of the % N on degree of substitution, these elemental analysis results indicate a molar degree of substitution (or dramatization) to be 17%.
The proton NMR of the lyophilized HA/ADH powder in water is displayed in FIG. 2. The proton spectrum displays a peak at between 1.6 and 2.3 ppm. The peak is assigned to the methylene protons in the adipic side chain. It should be noted that the magnetic environments are not completely averaged by motion as in the case of the free adipic dihydrazide. The methylene group next to the hydrazide linked to the HA gives rise to a peak at 2.38 ppm. The methylene group next to the free hydrazide end of adipic dihydrazide produces a peak at 2.25 ppm. The intermediate methylene groups are responsible for the remaining peaks between 1.6 and 2.1 ppm. The peaks at 3.4, 1.32 and 1.17 ppm are assigned to the N-acyl urea adduct of HA and DCC. The N-acyl urea adduct is present due to the known rearrangement of the O-acyl urea (i.e., the activated carboxylate moiety of the polymer) to the unreactive N-acyl urea form.
Evidence of DCC is found because DCC is not water soluble and therefore not removed via the purification process. However, the DCC evidenced is not free DCC. Rather, it is DCC reacted with HA but not displaced by the adipic dihydrazide. This does not depend on the solubility of DCC. It happens as well with EDC, which is water-soluble. N-acyl urea is typically a side product of the process, the resulting amount of which can be controlled by varying the proportions of HA, DCC and ADH.
The following example describes the process for preparing a palmitic hydrazide HA polymer. In this example, the derivation agent, palmitic hydrazide, is water insoluble, and the polymer activating agent is EDC, a water-soluble carbodiimide.
The first step includes placing approximately 2 L of a 0.6% hyaluronic acid (distributed by Optima Chemicals, Ltd., England) solution in a 4-L beaker and heating the HA solution to approximately 60� C. At the stated temperature, 0.33 g of palmitic hydrazide were added. The palmitic hydrazide was first dissolved in 15 ml of ethyl acetate and heated to approximately 50 degrees Centigrade. The solution was added slowly to the hyaluronic acid solution while mechanically mixed with a Silverson L4R mixer at 3500 rpm. The mixer maintained homogeneity within the emulsion while the pH was lowered to 4.55 with 1 M HCl.
While maintaining its pH at around 4.5, a solution of 0.306 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), previously dissolved in 10 ml distilled water, was added to the HA/ethyl acetate emulsion. The pH was maintained substantially in a range of about 4.2 to about 4.8 by addition of 1 N HCl. After pH stabilization was observed after approximately 25 minutes, the emulsion, which displayed a cloudy appearance, was neutralized with NaOH, and allowed to cool. The substantially neutral, cooled solution was circulated through a Minitan� filtration system with 300,000 molecular weight cutoff (MWCO) polysulfone membranes to remove unreacted palmitic hydrazide. Approximately 2L of the filtrate were collected. Ninhydrin tests were performed on the retentate, which was found negative for —NH2. The resulting product was lyophilized.
The following example describes the process for preparing a palmitic hydrazide-derivative HA polymer.
Initially, the process required preparing approximately 500 g of aqueous 0.64% 3.3 kDa hyaluronic acid solution in a tall 1-L beaker and heating the solution to about 65� C. The HA solution is first manufactured in our laboratories by alkaline hydrolysis of 1.3 Mda HA from Optima Chemicals, Inc. The molecular weight of the HA product was determined by viscosity measurements.
At the stated temperature, approximately 0.5884 g of palmitic hydrazide previously dissolved in approximately 10 ml of boiling ethyl acetate were blended with the hyaluronic acid solution. The addition was accomplished while agitating the mixture with a Polytron� mixer to maintain same as an emulsion. The pH of the emulsion formed thereby was thereafter lowered to approximately 4.56 with dropwise addition of 1.1 N HCl. Thereafter, a solution comprising approximately 0.66 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) in 10 ml distilled water was added to the emulsion. The pH of the emulsion was maintained within an approximate range of 4.6 to 4.8 by frequent dropwise addition of 1 N HCl until the pH was observed to stabilize. The pH of the stabilized emulsion was then adjusted to about 6.6 with NaOH approximately 50 minutes later.
The reaction mixture was allowed to cool down to room temperature and vacuum filtered over paper. A clear filtrate derived therefrom was added slowly to 1 L of reagent alcohol under magnetic stirring using a Corning stir plate. The precipitated polymer was separated by filtration, redissolved in 200 ml distilled water and lyophilized.
The following example describes the process for preparing a palmitic hydrazide HA-QUAT polymer.
The first part of the process included preparing approximately 500 g of 0.64% 3.3 kDa HAQuat in solution within a tall 1-L beaker, the HAQuat manufactured in our own laboratory, and heating the solution to about 65� C. At the stated temperature, about 0.58 g of palmitic hydrazide, previously dissolved in 10 ml of hot (60� C.) ethyl acetate, were added to the hyaluronic acid solution while agitating same with a Polytron mixer fitted with a 2″ o.d. generator head. The pH of the emulsion thus formed was lowered to 4.56 with 1.1 N HCl, and a solution of about 0.65 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) in 10 ml distilled water was added to same. The pH of the emulsion was maintained between 4.6 and 4.8 by frequent dropwise addition of 1 N HCl. Approximately 50 minutes after the pH was observed to be stabilized, the pH was readjusted to approximately 6.6 with NaOH. The emulsion was then allowed to cool down to room temperature and vacuum filtered over paper. A clear filtrate resulted and was added slowly to 1 L of 2-propanol under magnetic stirring. A resulting polymer precipitate was separated by filtration, redissolved in 200 ml distilled water and lyophilized.
The following example describes the process for preparing a palmitic hydrazide HA-QUAT polymer.
The first step required dissolving approximately 17 g of HAQuat Pilot III in 1 L H2O in a 4-L beaker. The solution was then heated to 60� C. At the stated temperature, approximately 0.32 g of palmitic hydrazide (TCI, lot F1E01) were dissolved in 10 ml of hot (60� C.) ethyl acetate and blended with the hyaluronic acid solution using a Polytron mixer with a 2″ o.d. generator head. The pH of the reaction mixture (emulsion) was lowered to approximately 4.43 with 1.1 N HCl and approximately 0.5 g of solid 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) were added to same. The pH of the resulting emulsion was maintained within a range of around 4.4 to 4.8 by frequent dropwise addition of 1 N HCl. Forty five minutes after pH stabilization, the pH was readjusted to approximately 7.8 with NaOH. The reaction mixture was allowed to cool down to room temperature and was vacuum filtered over paper. The clear filtrate was lyophilized to obtain palmitic hydrazide-derivative HAQUAT, as a white solid.
While the process and products herein described constitute preferred embodiments of the invention, it is to be understood that the invention is not limited to these precise processes and products. That is, it should be understood that changes made to the embodiments described herein without departing from the scope of the invention which is limited only by the appended claims.
|Cited Patent
|Filing date
|Publication date
|Apr 17, 1979
|Feb 17, 1981
|Damon Corporation
|Process for preparing semipermeable microcapsules
|Feb 21, 1984
|Aug 6, 1985
|Biotechnology Development Corporation
|Apparatus for forming emulsions
|May 26, 1987
|Mar 13, 1990
|Biotechnology Development Corporation
|Method of forming a microemulsion
|Mar 19, 1993
|Aug 1, 1995
|Collaborative Laboratories
|Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same
|Nov 30, 1993
|Apr 1, 1997
|The Research Foundation Of State University Of New York
|Functionalized derivatives of hyaluronic acid
|Citing Patent
|Filing date
|Publication date
|Dec 3, 2002
|Sep 17, 2013
|Soligenix, Inc.
|Stabilized reverse micelle compositions and uses thereof
|Dec 3, 2002
|Apr 14, 2005
|Constantinides Panayiotis P.
|Stabilized reverse micelle compositions and uses thereof
|U.S. Classification
|514/53, 514/54, 536/106, 536/123.1, 536/55.1, 536/55, 536/18.7, 536/17.2, 536/55.3
|International Classification
|Cooperative Classification
|European Classification
|May 9, 2000
Owner name: TRANSAMERICA BUSINESS CREDIT CORPORATION, ILLINOIS
Free format text: SECURITY AGREEMENT;ASSIGNOR:COLLABORATIVE GROUP, LTD. THE;REEL/FRAME:010776/0733
Effective date: 20000421
|Jan 18, 2002
Owner name: COLLABORATIVE TECHNOLOGIES, INC., NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COLLABORATIVE LABORATORIES, INC.;REEL/FRAME:012737/0904
Effective date: 20011023
|Apr 22, 2005
Owner name: ENGELHARD CORPORATION, NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COLLABORATIVE TECHNOLOGIES, INC.;REEL/FRAME:015931/0157
Effective date: 20050421
|Jan 9, 2006
|Fee payment
Year of fee payment: 4
|Dec 9, 2009
|Fee payment
Year of fee payment: 8
|Jan 7, 2014
|Fee payment
Year of fee payment: 12


text:
Hotels in Guangzhou
- Hotel list
- Hotels on map
- Sort by:
- Hotels on page
- Other hotels
- Airports
- Underground stations
- Train stations
- Parks
- Tourist attractions
- Museums
- Convention centers
- Stadiums
- Food and meals
- General
Hover above the icons to see hotel photo and details.
Click the hotel to go to the main hotel page.
Garden Hotel Guangzhou5 star hotel
Hilton Guangzhou Tianhe Hotel5 star hotel
Shangri-La Hotel Guangzhou5 star hotel
Sofitel Guangzhou Sunrich Hotel5 star hotel
Galaxy Hotel Guangzhou4 star hotel
New Century Hotel Guangzhou4 star hotel
Chateau Star River Guangzhou Hotel5 star hotel
Grand Hyatt Hotel Guangzhou5 star hotel
Hilton Guangzhou Baiyun Hotel5 star hotel
China Mayors Plaza Hotel Guangzhou4 star hotel
Crowne Plaza City Centre Hotel Guangzhou5 star hotel
Sheraton Guangzhou Hotel5 star hotel
Leeden Hotel Guangzhou4 star hotel
Westin Guangzhou5 star hotel
Warm Yes Business Hotel Guangzhou3 star hotel
Ritz - Carlton Hotel Guangzhou5 star hotel
The Royal Garden Hotel Guangzhou4 star hotel
The Ln Hotel Five Guangzhou4 star hotel
Fraser Suites Guangzhou5 star hotel
Guang Dong Victory Hotel Guangzhou4 star hotel
President Hotel Guangzhou4 star hotel
Nanyang Royal Hotel Guangzhou5 star hotel
Ascott Hotel Guangzhou5 star hotel
W Guangzhou Hotel5 star hotel
Four Seasons5 star hotel
Hotels near Guangzhou
{{ hotel.name }}{{ hotel.stars }} star hotel{{ hotel.distanceDesc }} | {{ hotellist.amenitiesDesc }}
{{ hotel.description }} More detailsFromUS${{ hotel.min_rate }}per nightNot availableMap goes hereChecking available rooms...{{ conf.title }}{{ room.name }}Prepayment requiredNon-refundableDeposit requiredBook with no credit cardFree cancellation
- {{rate.bedconf}}
{{ rate.currency }} {{ rate.price }}for nightChange roomPlease select Room {{ conf_index + 1 }}{{ conf.title }}
- {{rate.payathotel}}
- {{rate.one_euro_deposit}}
- {{rate.desc}}
- Smoking
- Non Smoking
- Pay at hotel
- {{rate.rate_id_desc}}
- {{rate.view}}
Room Type Conditions Rate Reservation
{{ room.desc }}
- {{amenity}}
{{ room.info }}
{{room.name}}{{ room.sqft }} sq. feet
Included: {{ room.rates[0].included }}
Not included: {{ room.rates[0].excluded }}Prepayment requiredNon-refundableDeposit requiredBook with no credit cardFree cancellation
- {{rate.bedconf}}
Show {{ room.rates.length - rooms.maxRates }} more ratesHide rates
- {{rate.payathotel}}
- {{rate.one_euro_deposit}}
- {{rate.desc}}
- Smoking
- Non Smoking
- Pay at hotel
- {{rate.rate_id_desc}}
- {{rate.view}}
{{ rate.currency }} {{ rate.price }}for night{{ conf.more_rooms_title }}
You can find more hotels by changing your search:
City Guide: Guangzhou
Fancy a trip down the ''Silk Road''?
It is the first that comes to mind when think of Guangzhou. This is a ''silk-woven destination'' as lies at the origin of the famed Silk Road – an extensive network of trade roads connecting east to west. These ways got their name thanks to lucrative silk trade and later saw exquisite Chinese porcelain and green tea leaves carried to major world destinations.Read more
City Guide: Guangzhou
Fancy a trip down the ''Silk Road''?
It is the first that comes to mind when think of Guangzhou. This is a ''silk-woven destination'' as lies at the origin of the famed Silk Road – an extensive network of trade roads connecting east to west. These ways got their name thanks to lucrative silk trade and later saw exquisite Chinese porcelain and green tea leaves carried to major world destinations.
You can experience it for yourself in Guangzhou with Booked.net. Be it a room in cheap hotel in Guangzhou or one packed with luxuries all our listings come with maps, photos and discount prices exclusive to Booked.net. It takes you just a click to book a hotel in Guangzhou – a birthplace of silk and a child of Pearl River Delta.
The waters of the river appear to be a source of life for Guangzhou as industrial hub and a home to 10 million people with 7.3million registered inhabitants and more than three million residents living unofficially. The territory of Guangzhou is densely packed with locals making it the third largest city in China after Hong Kong and Beijing.
As the main manufacturing hubs of the Delta, Hong Kong and Guangzhou make the river banks the most polluted region in China. It is here industry stretches in all directions alongside its waters. Despite the pollution, Guangzhou is safe to breathe in thanks to adjacent Baiyun Mountain – ''the lungs of the city''.
The road to the top of Baiyun Mountain is paved along with a large amount of places to entertain like badminton, football courts and bungee jumping spots. Otherwise, take a stroll of the city to see its numerous sights. Attractions include;
- Guangxiao Temple was destroyed and rebuilt several times thus, the building dates only from the mid 19th century.
- Liurong Temple, the 6th century temple and a must-see for every visitor
- Sanyuan Temple, the oldest one in the city
- Guangzhou City Art Museum has a good slice of art for you with more than 10,000 masterpieces
Thanks to its numerous temples and museums, Guangzhou was listed to 24 Chinese cities of the most cultural and historical significance. It is the stamp of Guangzhou history that makes it so culturally vibrant.
A city spanning 2,500 years its origins are lost in the mists of time. Most of the existing information about the city's roots come from legends and folk stories. The most popular legend, states Guangzhou was established by five celestial beings who offered sheaves of rice to local people as a symbol of prosperity and abundance. After the celestials left, Guangzhou quickly developed into an influential city.
Guangzhou is open for you to draw your own conclusions and findings. You can try to trace its origins right there in Guangzhou with Booked.net.
Filtering results
Please wait...
Your preferences
Star rating
- ({{ star.count }})
Accommodation type
- New Baiyun (81)
- Shenzhen (100)
- Fuoshan (72)
Popular areas
- City Center (435)
- Shamian Island (303)
Train stations
- South Guangzhou Station (247)
- Guangzhou East Train Station (343)
- Guangzhou East Railway Station (355)
Convention centers
Sport related
- Guangdong Olympic Stadium (80)
- Tianhe Stadium (381)
Shopping areas
- Baima clothing wholesale Market (405)
- Sand Creek international hotel supplies Market (69)
- Shangxiajiu Pedestrian Street (406)
Monuments and Landmarks
- Huacheng Square (39)
- Yuntai Garden (406)
Universities, Institutes
- Jinan University (363)
- South China University of Technology (294)
- Hai Zhu (317)
- Li Wan (853)
- Luo Gang (75)
- Tian He (362)
- Yue Xiu (828)
Underground stations
- Gangding Station (367)
- Jiangnanxi (358)
- Linhexi Station (364)
- Shipaiqiao Station (386)
- South China Normal University Station (315)
- Tianhe Coach Terminal Station (169)
- Tiyu Xilu Station (389)
- Wushan Station (262)
- Zhujiang New Town Station (425)
Hotel type
Search by name
Room facilities
Top hotels in Guangzhou
- Langham Place Guangzhou Hotel
- Park Hyatt Guangzhou Hotel
- Shangri-La Hotel Guangzhou
- Fraser Suites Guangzhou
- White Swan Hotel Guangzhou
- Four Seasons Hotel Guangzhou
- Crowne Plaza City Centre Hotel Guangzhou
- Grand International Hotel Guangzhou
- Ritz - Carlton Hotel Guangzhou
- Sofitel Guangzhou Sunrich Hotel
- Sheraton Guangzhou Hotel
- Garden Hotel Guangzhou
- Pullman Guangzhou Baiyun Airport Hotel
- Jianguo Hotel Guangzhou
- Westin Guangzhou Hotel
- Grand Hyatt Hotel Guangzhou
- Mandarin Oriental Hotel Guangzhou
- Holiday Inn Shifu Guangzhou
- Deerhill Hotel Guangzhou
- Leeden Hotel Guangzhou
- Canton Hotel
- Landmark Canton Hotel
- Majestic Hotel Guangzhou
- Holiday Inn Guangzhou Airport Zone
- Guang Zhou Blog Hotel Guangzhou
- St. Martin Hotel Guangzhou
- Cathay Hotel Guangzhou
- Four Seasons Spring Hotel Guangzhou
|Cities nearby
|Popular Cities in China


text:
Conference Sessions to include Preparing for a seamless transition to adult life, Paralysis research, clinical trials, and reasons for hope, Assistive technology and your child's IEP, Using computers to increase participation in meaningful activities, Complementary Alternative Medicine (CAM) as gross motor therapies, Health Care Consumer Assistance Program (HCCAP).
What does HCCAP stand for?
HCCAP stands for Health Care Consumer Assistance Program (disabled persons health care assistance; Trenton, NJ)
This definition appears rarely and is found in the following Acronym Finder categories:
- Military and Government
- Organizations, NGOs, schools, universities, etc.
See other definitions of HCCAP
Other Resources:
We have 1 other meaning of HCCAP in our Acronym Attic
- Abbreviation Database Surfer
- « Previous
- Next »
- Human Care Charities of America
- Hybrid Coordination Function Controlled Channel Access (wireless networking)
- Harlan County Community Action Agency (Kentucky, USA)
- Hereditary Cystatin C Amyloid Angiopathy (inherited brain disease)
- Hill Country Community Action Association (San Saba, TX)
- Howard County Center of African American Culture (Columbia, MD)
- Harford County Cultural Arts Board (Bel Air, MD)
- Heart City Child Advocacy Center (Valentine, NE)
- Hispanic Chamber of Commerce of Alameda County (California)
- Home Child Care Association of Ontario (Canada)
- Hepatitis C Caring Ambassadors Program (Vancouver, WA)
- Helmet Compatible Communication and Aural Protection
- Healthcare Compliance Certification Board (Minneapolis, MN)
- High Capacity Color Barcode
- Hill Country Community Band (Texas)
- Hindustan Coca-Cola Beverages (Coca-Cola India)
- Home Community Care Block Grant (North Carolina)
- Honolulu Community Concert Band (Honolulu, HI)
- Hardin County Chamber Business Alliance (Hardin County, Ohio)
- High Capacity Channel Bank Assembly


text:
It only takes a minute to get started. Fill out our uncomplicated sign up form and login to the site.
This step is optional but will dramatically boost your chances of getting interest from other over 40s members on the site. Write about yourself, your hobbies and attach a nice photograph of yourself.
Use our website's advanced search to spot over 40s members who satisfy your needs. Or just browse through listings and spot members that seem interesting.
Identified someone who tickles your fancy? Send them a word or two or just a wink and see what they say. With a little luck you'll be on your way to locating your proper match.
It'll only take 30 seconds


text:
Greetings friends,
I've noticed my Constructor sites aren't scaling on iPhones.
Everything scales down fine on Android and the iPad.
On the iPhone, though, only the upper left corner of the site is visible, and I can't scroll sideways or down to see the rest of the site.
Any suggestions?
Using most current versions of WP and Constructor.


text:
Lost bags and delays
Pros: Nothing I could particularly remark on
Cons: Travelling out to Budapest our flight was delayed about 40 minutes. We had a connection in Brussels and had to run from B terminal to A to reach on time. We reached the flight, however bags did not make the connection. We received bags next day at hotel. Travelling home, the flight was delayed 1h30m, the gates were shifted 3 times for departure, we had to sprint this time for conmection again B to A terminals. On the flight we were told Edinburgh connection would be rebooked so go to desk, however we made the flight just and so did the luggage, if we had waitied as told to rebook our luggage would have landed in Edinburgh with us stuck in Brussels. Won't be using again.


text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Ivan Volosyuk (JIRA)" <j...@apache.org>
|[jira] Created: (HARMONY-1371) [DRLVM][GC] gcv4.1 optimized allocation path
|Fri, 01 Sep 2006 15:15:24 GMT
[DRLVM][GC] gcv4.1 optimized allocation path -------------------------------------------- Key: HARMONY-1371 URL: http://issues.apache.org/jira/browse/HARMONY-1371 Project: Harmony Issue Type: Improvement Components: DRLVM Environment: Linux/Windows Reporter: Ivan Volosyuk Priority: Minor Attachments: gcv41_allocation_optimization_and_more.diff Allocation path optimization: reduced cleaned in advance memory. Fixed dead finalizible objects detection algorithm. Disabled force_gc() algorithm: triggers finalization problem on dacapo benchmark. -- This message is automatically generated by JIRA. - If you think it was sent incorrectly contact one of the administrators: http://issues.apache.org/jira/secure/Administrators.jspa - For more information on JIRA, see: http://www.atlassian.com/software/jira
|View raw message


text:
Militarized Police State Over Miami: "It's Only a Drill..."by Karen De Coster
Jan. 27, 2013
IRS Launches Investigation Of Clinton Foundation
France: Government Ordered Nice Police to Lie About Attack
WATCH: Julian Assange Mocks 'NSA D*ck Pic Guy' Who Claimed Russia Behind #DNCLeaks
VIDEO: Migrant Attacks Police at Frankfurt Airport in Germany
EU Chief On Terror: Turn Europe Into Surveillance State Rather Than Close Borders
Media Characterizes Military Invasion of South Florida as "Cool Tourist Story" [VIDEO]
Keeping the plebs on their toes: Military choppers startle downtown Miami [VIDEO]Diving Blackhawks, blank rounds of machine gun fire, strafing runs, troops rappelling from choppers, and road blockades. Local police + military. All over the skies of Miami at night, just a few days ago.ĀAccording to this local TV clown in the video, this event was for the purposes of "meeting requirements," preparing for overseas military drills, and making sure the equipment is in check. Can you say schmuck?
The paramilitary personnel chose to conduct this just as a Miami Heat game was coming to a conclusion and traffic and people were clogging in the streets.ĀAnd of course, no one knew this was only a show, and not the real thing. Again,Āhere's the official storyĀfor the hopelessly hapless who believe it:
The training is designed to ensure that military personnel are able to operate in urban areas and to focus on preparations for overseas deployment. It also serves as a mandatory trainingĀcertificationĀrequirement.It is so un-pc to say this anymore, especially post-Sandy Hook, but, ask any self-defense enthusiast, again, why they need military-style rifles and high-capacity magazines? Reason #1 is in this blog post and often repeated all over the country.ĀReason #2 is this: when gangs of leeches want to come and take what you have that theyĀdon'tĀhave.


text:
to experience the full functionality of mail.com.
Premium Login
Email Domains
iPhone App
Android App
iPad App
Browser download
1&1 MyWebsite
Weather Service
Credit Cards
Real Estate
Sign up
Sign up
Log in
Enhanced by Google
Carl Edwards
July 25, 2016
Busch hoping to use big Brickyard weekend for momentum
Kyle Busch used his first Brickyard 400 victory as a springboard to his first Sprint Cup title. He's trying to make sure it ...
July 08, 2016
Harvick gets Kentucky pole after rain cancels qualifying
Storms washed out qualifying at Kentucky Speedway on Friday, putting Kevin Harvick on the pole for Saturday night's Sprint ...
July 01, 2016
Greg Biffle wins 1st pole since 2012 with strong Daytona run
Ford found some extra power at one of NASCAR's fastest tracks — enough to put Greg Biffle on the pole for the first time in ...
June 25, 2016
Carl Edwards takes the pole for road course race at Sonoma
Carl Edwards edged AJ Allmendinger to earn the stop starting spot Sunday on the road course race at Sonoma Raceway.
May 29, 2016
The Latest: Day of firsts for Hamilton, Rossi and Truex
The latest on motorsport's busiest day, with Formula One's Monaco Grand Prix followed by the Indianapolis 500 and NASCAR's ...
May 14, 2016
Jimmie Johnson looks to extend track dominance at Dover
Jimmie Johnson fell in love with Dover the first time he turned a lap at the track in the late 1990s. He can't quit it, even ...
May 08, 2016
Kyle Busch keeps Joe Gibbs Racing at front of Sprint Cup
At the season-opening Daytona 500, Joe Gibbs Racing proved it was unquestionably the fastest, from Denny Hamlin taking the ...
May 06, 2016
Unpredictable Talladega gives way to predictable Kansas
The controversy that surrounded the crash-filled race at Talladega last weekend made its way to Kansas Speedway, where what ...
May 06, 2016
NASCAR revises format for All-Star Race at Charlotte
Brad Keselowski doesn't want to take all the credit for wholesale changes to the All-Star Race format. Perhaps because he ...
April 30, 2016
Chase Elliott wins pole at Talladega 30 years after his dad
Chase Elliott wasn't born yet when his father turned a record-setting lap to win the pole at Talladega Superspeedway.
April 27, 2016
Stewart focuses on 'fun' after NASCAR fine, policy change
Tony Stewart kept his thoughts to himself after NASCAR beefed up the penalties for using fewer than five lug nuts on each ...
April 24, 2016
Edwards passes Kyle Busch on last lap to win at Richmond
Carl Edwards had been grinding for 30 laps, doing everything he could to catch Joe Gibbs Racing teammate Kyle Busch in a ...
April 10, 2016
Kyle Busch wins at Texas to complete another NASCAR sweep
A broom was waiting for Kyle Busch in Victory Lane at Texas. Busch took the lead after the final restart Saturday night, ...
April 08, 2016
Jimmie Johnson certainly knows way to Victory Lane in Texas
Jimmie Johnson certainly knows his way to Victory Lane at Texas Motor Speedway. Already with two wins this season, Johnson ...
April 08, 2016
Edwards on Texas pole, 7th pole winner in 7 Cup races so far
Carl Edwards became the seventh different pole winner in the seven NASCAR Sprint Cup races this season, posting the fast lap ...
March 18, 2016
Austin Dillon takes the pole on a speedy day at Fontana
Austin Dillon won the pole for the NASCAR Sprint Cup race at Fontana on Friday, claiming the spot for the first time this ...
March 14, 2016
Longtime rivals race fair in Harvick's thrilling win
When Kevin Harvick and Carl Edwards started bumping side-by-side on the final lap Sunday, many NASCAR fans had to recall the ...
March 04, 2016
Kurt Busch claims pole in Las Vegas with 'insanely fast' lap
Kurt Busch has won the pole for Sunday's NASCAR Sprint Cup race in his hometown, claiming the spot for the second straight ...
February 22, 2016
Hamlin felt for teammate Kenseth after snatching Daytona 500
Four drivers went into the Daytona 500 determined to end Joe Gibbs' 23-year losing skid in NASCAR's biggest race of the year.
February 21, 2016
Pole-sitter Chase Elliott out of Daytona 500 early
Chase Elliott's run at a Daytona 500 victory ended in the grass. Just 19 laps into "The Great American Race," the Sprint Cup ...


text:
All hotels in Hawick, Scotland, United Kingdom
1 room, 2 adults
Borthwickbrae, Hawick, Scotland, TD9 7NA, United Kingdom, 800-491-6126
The Coppice, Scottish Borders
Lowest price$66
Best Price Guarantee
Upscale guesthouse in Hawick
- Free full breakfast, free WiFi in lobby, and free parking
Main amenities
- 5 guestrooms
- Tour/ticket assistance
For families
- Private bathroom
- Coffee/tea maker
- Flat-panel TV
- Free self parking
What's around
- Hawick Museum & Scott Art Gallery (6.1 mi / 9.8 km)
- Drumlanrigs Tower (6.2 mi / 10 km)
- Market Square (13 mi / 21 km)
- Halliwell's House Museum (13.1 mi / 21 km)
- Sir Walter Scott's Courtroom (13.1 mi / 21 km)
My friend and I had a delightful stay at the Coppice. The breakfasts were bountiful and…
My mum and I stayed here for one night and it was absolutely charming. Although it was a…
TripAdvisor Traveller Rating: 5
From 84 reviews
The Coppice, Scottish Borders
Hotel Info: 866-539-8117from $66
- Studio Apartment - Double Ensuite
- Twin Room
- Double En-suite
- Kingsize Double En-suite
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 5 rooms
- This hotel is arranged over 2 floors
- Check-in time 4 PM-9 PM
- Check-out time is 10:30 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free self parking
Nearby Four Star Scottish Borders hotels
In the hotel
Food and drink
- Free full breakfast daily
Things to do
- Golfing nearby
- Hiking/biking trails nearby
- Tours/ticket assistance
- Number of buildings/towers - 1
In the room
Home comforts
- Coffee/tea maker
Freshen up
- Private bathroom
- Shower only
Be entertained
- Flat-screen TV
Top Scottish Borders hotels
Recently reviewed hotels in Scottish Borders
- The Park Hotel PeeblesFrom
"Lovely rooms and baths! We enjoyed the breakfast very much. Good restaurant attached."May 30, 2016
- Seamore HouseFrom
"The Seamore House may not look great from the outside but the inside is decorated beautifully and the hosts are superb and breakfast was great. We were very pleased."May 18, 2016
- The Famous Star HotelFrom
"A warm welcome from the owner and staff."Mar 4, 2016
- Mercure Peebles Barony Castle HotelFrom
"Lovely looking hotel. Perfect couple of nights stay. Loved the tartan carpets! Pool was a bonus."Dec 6, 2015
Nearby hotels
Recent reviews
Outstanding 4.6 /5 from 48 reviews
The Coppice, Scottish Borders
We used this as a base for house hunting in the borders
The Coppice, Scottish Borders
Look no further than 'the Coppice'!!!
We made a last minute decision to book overnight accommodation and wanted somewhere to stay after spending the day up near Edinburgh. What a terrific place, the Coppice is surrounded by some beautiful countryside, absolutely ideal if you like the great outdoors. We were made to feel very welcome from the start, Jill is a great host. Room was lovely and spacious and we had a comfortable overnight stay with a lovely breakfast the following morning. Would have no hesitation in recommending this place to others.
The Coppice, Scottish Borders
Peaceful country escape
The owner of this B&B is very helpful with Lots of assistance and knowledge re area and further travels. Kind and hospitable for all requirements. The breakfast is really great and eaten in a delightful little atrium (conservative) .
The Coppice, Scottish Borders
Wonderful refuge.
We arrived about 6pm in a snowstorm, somewhat to landlady Jill's surprise, but we'd just been through a two-hour traffic jam from Selkirk. Jill very kindly microwaved us a supper we had with us -- nobody was driving this night -- and we had a warm, cosy "at home" evening. The breakfast next morning was wonderful, as ever, as was the chat and guidance from Jill and Jock.
The Coppice, Scottish Borders
Room was small. Tea & coffee in room, looked ok but coffee in tiny jar that you could not get spoon into and it did not look fresh. Host was not there when we arrived, although note was left to stay she would be back soon. Waited for 45 minutes and no sign of anyone. Had to drive 20 minutes to get phone signal to call and then back again, then all the host did was complain about another guest. Place looked good but was a bit far out in the sticks so if you want to get dinner, you had to drive for at least 20 minutes àlong very narrow one way lanes which would not be very enticing in the dark.
Is the description of this hotel not correct? Tell us


text:
- Gaming Guide
Deal Alert: 22nd February 2016
Didn't win last week's lottery? Not to worry, here's some deals to help you get over your disappointment.
4 things AMD's new Radeon Software Crimson Edition does better than Catalyst
Catalyst is out, Radeon Software is in. AMD's new Crimson driver improves on its predecessor in a lot of ways. Read on to find out what has changed.
4 High-end PCIe SSD drives tested for your next DIY PC
SSDs are fast, but the SATA interface has been the limiting factor in their performance. If you really want to take your system to the next level, consider these high-end PCIe-based SSDs. We have four such drives tested in great detail!
In Pictures: 9 artistic Xbox consoles for the Year of the Monkey
It's a little quirky, but these Microsoft Xbox One consoles are indeed eye-catching – even for the Lunar New Year. Perhaps these will inspire gaming sessions over the gatherings.
HWZ Deal Alert: 1st February 2016
Looking for some fresh new gadgets to celebrate the Lunar New Year? We've got you covered with some amazing deals.
HWZ Deal Alert: 29th January 2016
It's Friday! It's time to let your hair down and let your wallets loose and go shopping!
ASUS ROG GX700 Singapore launch - Meet the world's 1st liquid-cooled gaming notebook!
Just days ago, ASUS officially launched the ROG GX700 liquid-cooled gaming notebook to much fanfare. Find out more about this veritable beast of a gaming notebook after the jump!
HWZ Deal Alert: 25th January 2016
Mondays needn't be dreary when there are good deals to be had. Click here to find out some of the best deals that you can get today.
Battlegrounds we want to see in Star Wars Battlefront's upcoming DLC packs
Star Wars Battlefront has been out for some time and while we're enjoying it, we can't help but feel that it is missing some rather pivotal battles in the Star Wars saga. Here's our list of what EA should add in the DLC!
ASUS ROG GX700 and G752 review: Super-powered gaming notebooks
What makes a truly premium gaming notebook? Is it a powerful graphics card and processor, or is some extra magic required? A dedicated liquid-cooling dock for instance? We pit the sheer extravagance of the ASUS ROG GX700 against the G752 to see how well a luxury gaming notebook really performs.
Preview: ASUS' hardcore ROG GX700 liquid-cooled gaming notebook
At IFA 2015 earlier this year, ASUS debuted the ROG GX700, a notebook with a water-cooling dock. It's finally here in our labs and we can't help but give you our quick first impressions of this monstrous machine!
The greatest Star Wars games you have to play and some you shouldn't
With The Force Awakens movie out, we take a look back at the greatest and disastrous Star Wars games ever made! Many are worthwhile playing just for the storyline and great gameplay, so hop in and find out what they are.
3 reasons why Star Wars fans should play Star Wars Battlefront
Don't be mistaken, Star Wars Battlefront isn't just a game that's hoping to capitalize on Star Wars fever. If you are a fan of Star Wars, here are three reasons why Star Wars Battlefront shouldn't be missed.
HWZ Deal Alert: 31st December 2015
It may be the last day of the year, but that doesn't mean we don't still have a handful of deals lined up for you! From Creative speakers to a Samsung TV, check them out here!
Preview: ASUS ROG G752 17-inch gaming notebook with G-Sync
ASUS has updated its 17-inch gaming notebook offering with the new ROG G752. We check it out to see what this new model offers to gamers.
HWZ Deal Alert: 15th December 2015
Just one more week till Christmas! Whether you're getting a gift for friends, family or yourself, we've got some suggestions for you.
HWZ Deal Alert: 11th December 2015
TGIF! Just two weeks till Christmas! Time to get those last-minute presents bought and wrapped up. Haven't bought anything yet? Don't worry, we've got some great suggestions inside.
HWZ Deal Alert: 4th December 2015
It's Friday again and we are finally into the last month of the year. Usher in December with some great deals here!
HWZ Deal Alert (The Cyber Monday & Star Wars Edition): 30th November 2015
It's a new week, but don't be blue this Monday because it's Cyber Monday! And boy do we have a treat for Star Wars fans.
Cyber Monday 2015: Chase away the Monday blues with more deals and discounts!
The discounts aren't over yet: Following Black Friday, we have Cyber Monday. Click through for some great deals (and prepare to be poisoned).


text:
The Inglewood Hotel
The Inglewood Hotel
Hotel Guest Rating: 9.3/10
18 Holmfield Road
Blackpool FY2 9TB
Hotel Freebies Available*
• Free Internet Available show dates
The Inglewood Hotel
The Inglewood Hotel is just a few minutes' walk from Blackpool Beach. Offering free on-street parking, the family-run Inglewood is situated in the quiet North Shore area and close to Queen's Promenade.Double-glazed and centrally heated, The Inglewood offers rooms with bright décor, free WiFi, a flat-screen TV and tea and coffee-making facilities. All rooms are serviced daily and feature comfortable beds. A full English breakfast, prepared with local produce, is included in the room rate.Most attractions, including the North Pier, Winter Gardens, Opera House and town centre are within walking distance. Blackpool Tower is a 2-minute tram journey away. ...read more
The Inglewood Hotel Amenities
- Designated smoking area
- Express check-in/check-out
- Free WiFi
- Garden
- Golf course (within 3 km)
- Heating
- Library
- Luggage storage
- Non-smoking rooms
- Non-smoking throughout
- Safety deposit box
- Terrace
Hotel Information
Please advise the hotel of your estimated arrival time when booking. If you plan to arrive outside of the published check-in times, please inform the hotel.Group bookings of 8 people or more require a deposit per person, which is non-refundable. If cancelled with less than 7 days notice, or in case of a no-show the total amount of the booking will be charged. The credit card used to pay the deposit would be pre-authorised at the time of reservation.Please note that this property cannot accommodate hen and stag parties.
- Alpha Guest Accommodation from $57 (0mi)
- Beachcliffe Holiday Apartments (0mi)
- Langtrys from $142 (0mi)
- No. 14. B&B from $85 (0mi)
- North Crest from $84 (0mi)
- Poulton-Le-Fylde (3.5 mi)
- Hambleton (4.2 mi)
- Lytham St Annes (5.3 mi)
- Saint Annes (5.7 mi)
- Wrea Green (6.4 mi)
- Kirkham (7.9 mi)
- Garstang (11.6 mi)
- Cockerham (12.4 mi)
- Southport (14.2 mi)
- Preston (14.4 mi)
- Heysham (16.4 mi)
- Leyland (16.9 mi)
- Rufford (16.9 mi)
- Morecambe (17.1 mi)
- Longridge (17.7 mi)
- Lancaster (17.7 mi)
- Burscough (18.4 mi)
- Chipping (19.5 mi)


text:
PHILADELPHIA-Pennsylvania Real Estate Investment Trust has refinanced mortgages on two malls in Pennsylvania and one in Maryland for a total of $146.1 million.
The Philadelphia-based REIT refinanced loans on the Lycoming Mall, in Pennsdale, PA, the Viewmont Mall in Scranton, PA and the Francis Scott Key Mall in Frederick, MD. The company said the loans were refinanced at an average interest rate of 3.91% over terms of five years and generated proceeds of about $9.7 million. The new deals reduced average interest rates by 172 basis points, after the effect of interest rate swaps on the loans, company officials note.
The loan on Francis Scott Key Mall was increased from $55 million to $62.6 million, and contains an option to increase the balance further to $70.5 million under prescribed conditions.
"The completion of these transactions is further evidence of success in the company's ongoing effort to lower its overall financing costs while extending its maturity profile," said Joseph Coradino, CEO of PREIT. "We are pleased with our continued ability to achieve attractive financing terms on properties across the portfolio."
Lycoming Mall is a 800,000-square foot shopping center with sales per square foot of $270 as of December 31, 2012. Viewmont Mall is a 700,000-square foot mall with sales per square foot of $370 as of December 31, 2012. The Francis Scott Key Mall totals 700,000 square feet and posted sales per square foot of $344 as of December 31, 2012. All three malls are anchored by jcpenney, Macy's and Sears stores.


text:
- Home
- Listings
- Directories
- Renters Guide
- For Owners
- Blog
- About
Home › Building Directory › 10 Downing
10 Downing
10 Downing Street
New York, NY 10014
Cross streets:
Bedford Street, Avenue of the Americas
West Village
New York, NY 10014
Cross streets:
Bedford Street, Avenue of the Americas
West Village
Leasing Office
Rent range: $3850 to $4950
Available No Fee Apartments
|Unit # (click to view)
|Date Available
|Last Updated
|Call for Unit #
|1 Bath
|Call for Unit #
|1 Bedroom
|1 Bath
Building Features & Amenities
- Elevator
- Full-time Doorman
- Laundry in Building
- Fitness Center
- Units: 115
- Mid-rise (7-25 Floors)
- Pre-war Apartment Building
- Built 1940
- Rental Property
Pet policy: Pets OK , Diplomats allowed on a case-by-case basis Pet limit: 50lbs
Amidst the vibrant energy of the West Village, find your oasis at 10 Downing. This beautiful West Village apartment building features an interior garden, attended lobby, newly renovated pre-war residences, and a brand-new fitness center. Built in 1941 and renovated by Stonehenge NYC, 10 Downing epitomizes high-class living and the charm of a tree-lined block.
Application and Move-in Information
- Insurent Accepted
Owner / Manager / Leasing Information
For more information on this building, contact:
Property Management:
Stonehenge NYC


text:
intransitive verb
- [formal]to redound to somebody's advantageredundar en beneficio de alguienit can only redound to our creditsolo puede aumentar nuestro prestigio or buen nombreExample sentences
- Whether these efforts will redound to the benefit of taxpayers, will only be known come Budget Day 2004.
- I heard one caller to a radio show suggest that this might redound to our benefit, since all they understand in that region is strength.
- I assure you that it will redound to the social, academic and financial well-being of us all.
Definition of redound in:
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
Grammar and usage help for Spanish:
= trending


text:
"had sex with the seventh infantry division last night , kind of sore today"
--Ron Casados on Facebook
"the what? I'm stockpiling twinkies I guess"
--John Philip Henry on Facebook
"Friday I will commit every sin in the book, saturday I'll cry like a baby, sunday I'll say I told you so.."
--Raga Tanha on Facebook
"My trunk is cleaned out in preparation for looting."
--Garrett Jamieson on Facebook
Every week we ask our friends on Facebook, Twitter, and the comments section below a pressing question, and the best answers appear in print. Make sure you follow us @cl_atlanta or are a fan so you can be part of the conversation.


text:
Hearing aids in Salem, NH
We found 17 hearing clinics with 61 reviews within 22.9 miles of Salem, NH.
Featured hearing professionals near you
Michele McCarthy, Au.D.
Michele received her B.S. in Speech Pathology and her M.S. in Audiology from Purdue University. She (read more)
Wendy Ring, MS, CCC-A
Audiologist Wendy Ring is a caring professional with over 20 years experience in the hearing aid and (read more)
Carolyn Drury, MS
Carolyn Drury joined the practice in 2000 and has been a practicing Audiologist since 1980. She (read more)
Colden and Seymour ENT - Newburyport
Sarah Wellwood, AuD, CCC-A, FAAA
Sarah Wellwood received her undergraduate degree from Indiana University then went on to earn her (read more)
Marilyn Howard, Au.D.
Dr. Marilyn Howard has over 20 years of experience in the audiology field. She earned her Masters (read more)
Peggy Sheets, AuD
Dr. Sheets is originally from Massena, NY. She earned her undergraduate degree in psychology with a (read more)
Karen Lukeman, AuD, CCC-A
Karen Lukeman earned her M.S. in Audiology from Northeastern University and her doctorate in (read more)
David Dachowski, BS, HIS
David Dachowski, known as "The Hearing Aid Man", has almost 25 years experience (read more)
Mass Audiology - The Hearing People - Peabody - Andover Street
Mitch Stein, LHIS
Mitch Stein is a Massachusetts licensed Hearing Instrument Specialist and serves patients at the (read more)
Megan Ford, Au.D., CCC-A, FAAA
Megan earned her Doctor of Audiology degree from Salus University and a Master's degree in (read more)
Additional professionals near you
MJD Hearing Aid Center
View Clinic Details
Andover ENT Center, Inc.
View Clinic Details
Audio Hearing Center - Lowell
View Clinic Details
Dr Woods Hearing Center, LLC
View Clinic Details
Hearing Solutions NE - Nashua
View Clinic Details
New England Audiological
View Clinic Details
Sound Choice Inc. - Danvers
View Clinic Details