text:
Endurance exercise and metabolism are linked to transcriptional activation of human telomeres, researchers propose.
Not Immune to Fat
November 1, 2015|
The effect of a high-fat diet on murine T cells
November 1, 2015|
The effect of a high-fat diet on murine T cells
October 27, 2015|
The World Health Organization recommends more pilot trials.
October 21, 2015|
Researchers identify a subset of proinflammatory cytokine-producing B cells that may spark multiple sclerosis-related inflammation.
October 21, 2015|
Researchers design antibody-like proteins to awaken and destroy HIV holdouts.
October 19, 2015|
Researchers identify a new type of brain cell in male Caenorhabditis elegans.
September 15, 2015|
Researchers characterize a protein that could be key to the virus's virulence—and to developing a vaccine against the mosquito-borne disease.
September 14, 2015|
A genetic predisposition toward learning poorly from negative outcomes may influence behaviors leading to weight gain, a study shows.
September 10, 2015|
Cortical interneurons in mice exhibit activity-dependent alterations to their characteristic firing patterns.
September 8, 2015|
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.
September 1, 2015|
Reviving a decades-old hypothesis of autoimmunity


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Welcome to our new website.
With the help of the Vaughan Group – vaughangroup.ca – we are proud to present our newly designed website! Take a look around and tell us what you think by emailing us at email@example.com.
Prince Edward County Memorial Hospital Foundation
Since being founded in 1985, the PECMH Foundation's job has been to serve the funding needs of our hospital. That means that while the Ontario Ministry of Health, pays for the day-to-day hospital operations, the Foundation raises money in our community for the building, repairs and maintenance and for the purchase of high priority medical equipment needed for patient care.
Donate Now.
Prince Edward County Memorial Hospital Foundation raises money to advance health care for our patients. Help maintain exceptional health care in The County.
We Serve You.
Each year, our County hospital staff treats more than 18,000 people for all manner of health care needs with approximately 1,000 admitted for further care, many for acute medical conditions such as pneumonia and heart attacks. The average stay is 6.5 days at an average cost for acute inpatient care of $5,800.
You Make the Difference.
Your financial gifts are the reason we are able to provide needed exceptional medical care and treatment for you, your family, friends and neighbours. The normal lifespan of medical equipment is five to 10 years, so ongoing annual fund raising is crucial. On behalf of the PECMHF Board of Directors, staff and the patients we serve, we thank our donors for your generous support. Your donations, bequests and fundraising make all of our projects possible. Thank you!
Our Strength Comes from Building Partnerships
The Foundation's goal is to build partnerships in the County with individuals, businesses and industry, service organizations, social clubs, church groups and others who will work with us to meet the needs of our fundraising endeavours. Supporting our hospital in this central role cannot be managed alone; it can only succeed through the strength of coming together as community partners.


text:
Highest Rated Titles With Dulcie Scott
- Job Types
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- On TV
- Release Year
Downton Abbey (2010–2015)
Episode #1.7
TV-PG | 64 min | Drama, Romance
Mary finds it was Edith who let the ambassador know about Faruk's death, Cora announces her pregnancy, and Thomas and O'Brien hatch new slanders against Bates as War clouds loom.
Writer: Julian Fellowes | Director: Brian Percival | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 925
Downton Abbey (2010–2015)
Episode #3.5
TV-PG | 50 min | Drama, Romance
The Crawley family faces its severest test yet. Meanwhile, new faces try to fit into the tight-knit circle of servants. New evidence turns up in a baffling case.
Writer: Julian Fellowes | Director: Jeremy Webb | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 856
3. Downton Abbey (2010–2015)
TV-PG | 58 min | Drama, Romance
A chronicle of the lives of the British aristocratic Crawley family and their servants in the early 20th Century.
Creator: Julian Fellowes | Stars: Hugh Bonneville, Phyllis Logan, Elizabeth McGovern, Brendan Coyle
Votes: 111,512
Downton Abbey (2010–2015)
Episode #3.1
TV-PG | 68 min | Drama, Romance
Spring of 1920. Wedding guests descend on Downton Abbey, where disasters threaten. One of which is Cora's freewheeling American mother, who tries to loosen up her in-laws.
Writer: Julian Fellowes | Director: Brian Percival | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 1,081
Inspector George Gently (2007– )
Goodbye China
88 min | Crime, Drama, Mystery
Gently and Bacchus look into the suspicious death of Gently's old friend and ex-snout, China.
Writers: Alan Hunter, Peter Flannery | Director: Gillies MacKinnon | Stars: James Acton, Jay Miller, Niek Versteeg, Martin Shaw
Votes: 173
Downton Abbey (2010–2015)
Episode #1.3
TV-PG | 47 min | Drama, Romance
Gwen's ambitions to leave service to become a secretary is discouraged, Bates takes painful steps to overcome his limp, and a dashing Turkish diplomat visiting Downton seems to work his charms on everyone - especially Mary.
Writer: Julian Fellowes | Director: Ben Bolt | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 999
Downton Abbey (2010–2015)
Episode #1.5
TV-PG | 49 min | Drama, Romance
Bates sees Thomas stealing a bottle of wine, the footman tries to frame him for petty theft, and Mrs. Crawley tries to convince the Countessa to surrender her annual entitlement prize for best rose in the village.
Writer: Julian Fellowes | Director: Brian Kelly | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 884
Downton Abbey (2010–2015)
Episode #1.6
TV-PG | 48 min | Drama, Romance
O'Brien and Thomas continue their efforts to frame Bates, Mary falls in love with Matthew, and Sybil is injured in a political disturbance and Branson is blamed.
Writers: Julian Fellowes, Tina Pepler | Director: Brian Percival | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 892
Downton Abbey (2010–2015)
Episode #3.3
TV-PG | 51 min | Drama, Romance
The fate of Downton Abbey hinges on a letter from a dead man. Edith and Sir Anthony face their own fateful moment. Mrs. Hughes confronts a crisis.
Writer: Julian Fellowes | Director: Andy Goddard | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 709
Downton Abbey (2010–2015)
Episode #1.1
TV-PG | 66 min | Drama, Romance
The family and staff of Downton are shocked when they find that the heir to the title and fiancé of the Earl's daughter Mary perished on the Titanic and the Earl hires a crippled army comrade as valet.
Writer: Julian Fellowes | Director: Brian Percival | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 1,390
Downton Abbey (2010–2015)
Episode #1.2
TV-PG | 47 min | Drama, Romance
The new legal heirs to Downton, lawyer Matthew Crawley and his nurse mother Isobel are invited to live on the estate, but there is resentment of them as interlopers from both up and downstairs as interlopers.
Writer: Julian Fellowes | Director: Ben Bolt | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 1,055
Downton Abbey (2010–2015)
Episode #1.4
TV-PG | 47 min | Drama, Romance
Mrs. Hughes is reunited with an old beau, now a widower proposing marriage, and the Countess hires Matthew Crawley to see if the will can be broken and disagrees with his mother on a diagnosis.
Writers: Julian Fellowes, Shelagh Stephenson | Director: Brian Kelly | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 908
Downton Abbey (2010–2015)
Episode #3.8
TV-PG | 67 min | Drama, Romance
Change arrives in a big way for several key characters at Downton Abbey. A yearly cricket match with the village sees old scores settled and new plots are hatched.
Writer: Julian Fellowes | Director: David Evans | Stars: Hugh Bonneville, Laura Carmichael, Jim Carter, Brendan Coyle
Votes: 716
Downton Abbey (2010–2015)
Episode #3.6
TV-PG | 48 min | Drama, Romance
Things go badly amiss at Downton Abbey. Robert and Cora are not speaking. The servants are shunning Matthew's mother, Isobel. And Matthew and Robert have fallen out. Bates takes a gamble.
Writer: Julian Fellowes | Director: Jeremy Webb | Stars: Hugh Bonneville, Laura Carmichael, Jim Carter, Brendan Coyle
Votes: 662
Downton Abbey (2010–2015)
Episode #3.7
TV-PG | 48 min | Drama, Romance
A vindictive Ms. O'Brien hatches a damaging plot. Edith make a major decision. Matthew has a major plan for changing things, and Tom's brother pays a visit.
Writer: Julian Fellowes | Director: David Evans | Stars: Hugh Bonneville, Laura Carmichael, Jim Carter, Brendan Coyle
Votes: 660
Downton Abbey (2010–2015)
A Journey to the Highlands
TV-PG | 92 min | Drama, Romance
September 1921. The Crawleys head to a Scottish hunting lodge, while the downstairs staff stays behind at Downton Abbey. New romances flare up, and a crisis unfolds.
Writer: Julian Fellowes | Director: Andy Goddard | Stars: Hugh Bonneville, Laura Carmichael, Jim Carter, Brendan Coyle
Votes: 1,077
Downton Abbey (2010–2015)
Episode #3.2
TV-PG | 48 min | Drama, Romance
A conflict between two members of the house staff escalates. Meanwhile, the family tries to impress Martha by planning a lavish dinner party.
Writer: Julian Fellowes | Director: Brian Percival | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 734
Downton Abbey (2010–2015)
Episode #3.4
TV-PG | 48 min | Drama, Romance
August 1920: Two social revolutions arrive at Downton Abbey: the Irish civil war and the fight for women's suffrage. A mysterious conspiracy keeps Anna and Bates apart.
Writer: Julian Fellowes | Director: Andy Goddard | Stars: Hugh Bonneville, Jessica Brown Findlay, Laura Carmichael, Jim Carter
Votes: 683
Inspector George Gently (2007– )
Gently Upside Down
89 min | Crime, Drama, Mystery
When the body of a missing schoolgirl is discovered in a wood, Gently and Bacchus are thrown into the new world of pop and media celebrity.
Writers: Alan Hunter, Peter Flannery, Stewart Harcourt | Director: Nicholas Renton | Stars: Vincent Regan, Kate Bracken, Jade Byrne, Kieran Bew
Votes: 148
20. Inspector George Gently (2007– )
89 min | Crime, Drama, Mystery
With the help of DS John Bacchus, Inspector George Gently spends his days bringing to justice members of the criminal underworld who are unfortunate enough to have the intrepid investigator assigned to their cases.
Creator: Peter Flannery | Stars: Martin Shaw, Lee Ingleby, Simon Hubbard, Lisa McGrillis
Votes: 3,384
21. Black Book (2006)
R | 145 min | Drama, Thriller, War
In the Nazi-occupied Netherlands during World War II, a Jewish singer infiltrates the regional Gestapo headquarters for the Dutch resistance.
Writers: Gerard Soeteman, Paul Verhoeven | Director: Paul Verhoeven | Stars: Carice van Houten, Sebastian Koch, Thom Hoffman, Halina Reijn
Votes: 59,373 | Gross: $4.40M
22. Crime and Punishment (2002 TV Movie)
200 min | Crime, Drama
Writers: Fyodor Dostoevsky, Tony Marchant | Director: Julian Jarrold | Stars: John Simm, Ian McDiarmid, Shaun Dingwall, Geraldine James
Votes: 507
23. Babel (I) (2006)
R | 143 min | Drama
Tragedy strikes a married couple on vacation in the Moroccan desert, touching off an interlocking story involving four different families.
Writers: Guillermo Arriaga, Alejandro G. Iñárritu | Director: Alejandro G. Iñárritu | Stars: Brad Pitt, Cate Blanchett, Gael García Bernal, Mohamed Akhzam
Votes: 243,315 | Gross: $34.30M
24. 13 Hours (2016)
R | 144 min | Action, Drama, Thriller
During an attack on a U.S. compound in Libya, a security team struggles to make sense out of the chaos.
Writers: Chuck Hogan, Mitchell Zuckoff | Director: Michael Bay | Stars: John Krasinski, Pablo Schreiber, James Badge Dale, David Denman
Votes: 44,463 | Gross: $52.82M
25. The Queen (2006)
PG-13 | 103 min | Biography, Drama
After the death of Princess Diana, Queen Elizabeth II struggles with her reaction to a sequence of events nobody could have predicted.
Writer: Peter Morgan | Director: Stephen Frears | Stars: Helen Mirren, Michael Sheen, James Cromwell, Alex Jennings
Votes: 85,120 | Gross: $56.44M
26. Valkyrie (2008)
PG-13 | 121 min | Drama, History, Thriller
A dramatization of the 20 July assassination and political coup plot by desperate renegade German Army officers against Hitler during World War II.
Writers: Christopher McQuarrie, Nathan Alexander | Director: Bryan Singer | Stars: Tom Cruise, Bill Nighy, Carice van Houten, Kenneth Branagh
Votes: 182,734 | Gross: $83.08M
27. Imagine Me & You (2005)
R | 90 min | Comedy, Drama, Romance
A newlywed bride becomes infatuated with another woman, who questions her sexual orientation, promoting a stir among the bride's family and friends.
Writer: Ol Parker | Director: Ol Parker | Stars: Piper Perabo, Lena Headey, Matthew Goode, Celia Imrie
Votes: 22,932 | Gross: $0.67M
28. Shadows in the Sun (2005)
100 min | Comedy, Drama, Romance
An aspiring young writer (Jackson) tracks a literary titan (Keitel) suffering from writers block to his refuge in rural Italy and learns about life and love from the irascible genius and his daughters.
Writer: Brad Mirman | Director: Brad Mirman | Stars: Harvey Keitel, Claire Forlani, Giancarlo Giannini, Joshua Jackson
Votes: 3,270
29. Madame Bovary (2000 TV Movie)
180 min | Drama, Romance
A young woman in her late teens, a reader of novels and with high hopes of romance and passion, marries a widowed country doctor. Although he dotes on her, she is soon bored and discontent.... See full summary »
Writers: Gustave Flaubert, Heidi Thomas | Director: Tim Fywell | Stars: Frances O'Connor, Greg Wise, Eileen Atkins, Hugh Bonneville
Votes: 679
30. Muppets Most Wanted (2014)
PG | 107 min | Adventure, Comedy, Crime
While on a grand world tour, The Muppets find themselves wrapped into an European jewel-heist caper headed by a Kermit the Frog look-alike and his dastardly sidekick.
Writers: James Bobin, Nicholas Stoller, Jim Henson | Director: James Bobin | Stars: Ricky Gervais, Ty Burrell, Tina Fey, Steve Whitmire
Votes: 24,207 | Gross: $51.18M
31. Ordinary Decent Criminal (2000)
R | 93 min | Comedy, Crime
Brilliant, flamboyant master criminal Michael Lynch is more interested in his image and his posterity than the actual profit from his ill-gotten gains.
Writer: Gerard Stembridge | Director: Thaddeus O'Sullivan | Stars: Kevin Spacey, Linda Fiorentino, Peter Mullan, Stephen Dillane
Votes: 11,643
32. The Mummy Returns (2001)
PG-13 | 130 min | Action, Adventure, Fantasy
The mummified body of Imhotep is shipped to a museum in London, where he once again wakes and begins his campaign of rage and terror.
Writer: Stephen Sommers | Director: Stephen Sommers | Stars: Brendan Fraser, Rachel Weisz, John Hannah, Arnold Vosloo
Votes: 247,465 | Gross: $202.01M
33. Night at the Museum: Secret of the Tomb (2014)
PG | 98 min | Adventure, Comedy, Family
Larry spans the globe, uniting favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.
Writers: David Guion, Michael Handelman, Mark Friedman, Thomas Lennon, Robert Ben Garant | Director: Shawn Levy | Stars: Ben Stiller, Robin Williams, Owen Wilson, Dick Van Dyke
Votes: 66,778 | Gross: $113.73M
34. Chéri (2009)
R | 86 min | Comedy, Drama, Romance
The son of a courtesan retreats into a fantasy world after being forced to end his relationship with the older woman who educated him in the ways of love.
Writers: Christopher Hampton, Colette | Director: Stephen Frears | Stars: Michelle Pfeiffer, Rupert Friend, Kathy Bates, Frances Tomelty
Votes: 8,907 | Gross: $2.71M
35. Into the Woods (2014)
PG | 125 min | Adventure, Fantasy, Musical
A witch tasks a childless baker and his wife with procuring magical items from classic fairy tales to reverse the curse put on their family tree.
Writers: James Lapine, Stephen Sondheim | Director: Rob Marshall | Stars: Anna Kendrick, Meryl Streep, Chris Pine, Emily Blunt
Votes: 100,682 | Gross: $128.00M
36. Bedazzled (2000)
PG-13 | 93 min | Comedy, Fantasy, Romance
Hopeless dweeb Elliot Richards is granted 7 wishes by the devil to snare Allison, the girl of his dreams, in exchange for his soul.
Writers: Peter Cook, Dudley Moore, Larry Gelbart, Harold Ramis, Peter Tolan | Director: Harold Ramis | Stars: Brendan Fraser, Elizabeth Hurley, Frances O'Connor, Miriam Shor
Votes: 81,743 | Gross: $37.88M
37. Hyde Park on Hudson (2012)
R | 94 min | Biography, Comedy, Drama
The story of the love affair between FDR and his distant cousin Margaret "Daisy" Suckley, centered around the weekend in 1939 when the King and Queen of the United Kingdom visited upstate New York.
Writer: Richard Nelson | Director: Roger Michell | Stars: Bill Murray, Laura Linney, Olivia Williams, Samuel West
Votes: 9,332 | Gross: $6.37M
38. Pride and Prejudice and Zombies (2016)
PG-13 | 107 min | Action, Horror, Romance
Five sisters in 19th century England must cope with the pressures to marry while protecting themselves from a growing population of zombies.
Writers: Burr Steers, Jane Austen, Seth Grahame-Smith | Director: Burr Steers | Stars: Lily James, Sam Riley, Jack Huston, Bella Heathcote
Votes: 22,858 | Gross: $10.91M
39. The Gunman (2015)
R | 115 min | Action, Crime, Drama
A sniper on a mercenary assassination team, kills the minister of mines of the Congo. Terrier's successful kill shot forces him into hiding. Returning to the Congo years later, he becomes the target of a hit squad himself.
Writers: Jean-Patrick Manchette, Don MacPherson, Pete Travis, Sean Penn | Director: Pierre Morel | Stars: Sean Penn, Idris Elba, Jasmine Trinca, Javier Bardem
Votes: 28,219 | Gross: $10.64M
40. Wrath of the Titans (2012)
PG-13 | 99 min | Action, Adventure, Fantasy
Perseus braves the treacherous underworld to rescue his father, Zeus, captured by his son, Ares, and brother Hades who unleash the ancient Titans upon the world.
Writers: Dan Mazeau, David Leslie Johnson, Greg Berlanti, Beverley Cross | Director: Jonathan Liebesman | Stars: Sam Worthington, Liam Neeson, Rosamund Pike, Ralph Fiennes
Votes: 152,398 | Gross: $83.64M
41. What a Girl Wants (2003)
PG | 105 min | Comedy, Drama, Family
An American teenager learns that her father is a wealthy British politician running for office. Although she is eager to find him, she realizes it could cause a scandal and cost him the election.
Writers: William Douglas-Home, Jenny Bicks, Elizabeth Chandler | Director: Dennie Gordon | Stars: Amanda Bynes, Colin Firth, Kelly Preston, Eileen Atkins
Votes: 47,959 | Gross: $35.99M
42. Your Highness (2011)
R | 102 min | Adventure, Comedy, Fantasy
When Prince Fabious's bride is kidnapped, he goes on a quest to rescue her... accompanied by his lazy useless brother Thadeous.
Writers: Danny McBride, Ben Best | Director: David Gordon Green | Stars: Danny McBride, Natalie Portman, James Franco, Rasmus Hardiker
Votes: 85,069 | Gross: $21.56M
43. Alexander (2004)
R | 175 min | Action, Adventure, Biography
Alexander, the King of Macedonia and one of the greatest military leaders in the history of warfare, conquers much of the known world.
Writers: Oliver Stone, Christopher Kyle, Laeta Kalogridis | Director: Oliver Stone | Stars: Colin Farrell, Anthony Hopkins, Rosario Dawson, Angelina Jolie Pitt
Votes: 138,586 | Gross: $34.29M
44. I Want Candy (2007)
R | 87 min | Comedy
Joe and Baggy are two misfit English film school students whose first movie goes awry. Desperate to finance their flick, they turn to a porn producer who agrees to give them the money ... See full summary »
Writers: Peter Hewitt, Phil Hughes, Jamie Minoprio, Jonathan M. Stern, Piers Thompson, Olivia Glazebrook, Fred Wolf, Jimmy Carr | Director: Stephen Surjik | Stars: Tom Riley, Tom Burke, Carmen Electra, Eddie Marsan
Votes: 6,671
45. Breathtaking (2000)
100 min | Thriller
A beautiful psychiatrist befriends an abused patient, ultimately leading to lust and murder.
Writer: Nicky Cowan | Director: David Green | Stars: Joanne Whalley, Lorraine Pilkington, Neil Dudgeon, Amy Bamberger
Votes: 168
46. Will (2017 TV Mini-Series)
Drama | Announced
a drama about the exploits of young William Shakespeare. The series begins with Shakespeares arrival in the raucous London theater scene of the 16th century.
Stars: Leon Annor, Jamie Beamish, James Berkery, Dean-Charles Chapman
Will (2017– )
Episode #1.1
Stars: Leon Annor, Jamie Beamish, James Berkery, Dean-Charles Chapman


text:
Lemon Cilantro Eggplant Dip
Total Time
Prep 10 mins
Cook 45 mins
The light, nutty flavor of tahini, an essential ingredient in hummus, pairs perfectly with rich roasted eggplant in this delicious Mediterranean dip. From Good Housekeeping.
Ingredients Nutrition
- 2 eggplants, 1 pound each, each halved lengthwise
- 4 garlic cloves, unpeeled
- 3 tablespoons tahini, sesame puree
- 3 tablespoons fresh lemon juice
- salt, to taste
- 1⁄4 cup loosely packed cilantro or 1⁄4 cup loosely packed mint leaf, chopped
- Preheat oven to 425 degrees F.
- Line a 15 1/2" by 10 1/2" jelly-roll pan with nonstick foil (or use regular foil and spray with nonstick cooking spray).
- Place eggplant halves, skin-sides up, in foil-lined pan.
- Wrap garlic in foil and place in pan with eggplants.
- Roast vegetables 45 to 50 minutes or until eggplants are very tender and skin is shriveled and browned.
- Unwrap garlic.
- Cool eggplants and garlic until easy to handle.
- When cool, scoop eggplants' flesh into food processor with knife blade attached.
- Squeeze out garlic pulp from each clove and add to food processor with tahini, lemon juice, and 3/4 teaspoon salt; pulse to coarsely chop.
- Spoon dip into serving bowl; stir in cilantro.
- Cover and refrigerate at least 2 hours.
- Serve dip with pita and vegetables.
Most Helpful
Excellent!! I recently did a detox where almost everything was off limits and had to eat tons of Fresh veggies - this really adds zip to boring food & is not bad for you at all!!
This was good, but I don't know if I'd say amazing. My husband, who hates eggplant even liked it (before I told him it was eggplant!) I used fresh parsley instead of cilantro but will try again as written. I was more generous on the lemon juice as I like things lemony! Would be very good on top of falafel instead of hummus.


text:
Testing environmental and genetic effects in the presence of spatial autocorrelation
Version of Record online: 18 FEB 2014
DOI: 10.1111/ecog.00566
© 2014 The Authors
Volume 37, Issue 8, pages 781–790, August 2014
Additional Information
How to Cite
Rousset, F. and Ferdy, J.-B. (2014), Testing environmental and genetic effects in the presence of spatial autocorrelation. Ecography, 37: 781–790. doi: 10.1111/ecog.00566
Publication History
- Issue online: 1 AUG 2014
- Version of Record online: 18 FEB 2014
- Manuscript Accepted: 30 DEC 2013
Funded by
- (PEPS) 'Comprendre les maladies émergentes et les épidémies'
- Abstract
- Article
- References
- Cited By
Spatial autocorrelation is a well-recognized concern for observational data in general, and more specifically for spatial data in ecology. Generalized linear mixed models (GLMMs) with spatially autocorrelated random effects are a potential general framework for handling these spatial correlations. However, as the result of statistical and practical issues, such GLMMs have been fitted through the undocumented use of procedures based on penalized quasi-likelihood approximations (PQL), and under restrictive models of spatial correlation. Alternatively, they are often neglected in favor of simpler but more questionable approaches. In this work we aim to provide practical and validated means of inference under spatial GLMMs, that overcome these limitations. For this purpose, a new software is developed to fit spatial GLMMs. We use it to assess the performance of likelihood ratio tests for fixed effects under spatial autocorrelation, based on Laplace or PQL approximations of the likelihood. Expectedly, the Laplace approximation performs generally slightly better, although a variant of PQL was better in the binary case. We show that a previous implementation of PQL methods in the R language, glmmPQL, is not appropriate for such applications. Finally, we illustrate the efficiency of a bootstrap procedure for correcting the small sample bias of the tests, which applies also to non-spatial models.


text:
Cell Therapy for Diabetes Using Piscine Islet Tissue
Abstract:The islet tissue, called Brockmann bodies, in certain teleost fish is anatomically distinct from the pancreatic exocrine tissue and can be easily identified macroscopically. Expensive islet isolation procedures, such as required when procuring islet tissue from mammalian pancreases, are unnecessary. Tilapia islets transplanted into diabetic athymic nude mice will produce long-term normoglycemia and mammalian-like glucose tolerance profiles. Encapsulated tilapia islets function well after transplantation into euthymic recipients. Additionally, tilapia are potentially ideal xenogeneic donors because of markedly lower donor production costs, minimal islet procurement costs, and possibly decreased xenozoonotic potential relative to mammalian donors. Tilapia islets appear to be appropriately glucose responsive with high insulin output, can be cryopreserved, and are much more resistant to hypoxia than mammalian islets. Because tilapia and human insulin differ by 17 amino acids, we have cloned, sequenced, and modified the tilapia insulin gene by site-directed mutagenesis resulting in a tilapia insulin gene that codes for "humanized" insulin while still maintaining all of the tilapia regulatory (noncoding) sequences. We have now produced small numbers of founder transgenic tilapia with incorporation of our humanized tilapia insulin gene construct, and we have shown transmission and expression of the transgene in the beta cells and serum of their F1 offspring. Our ultimate goal is to achieve homologous recombination and to breed for homozygosity for the hybrid insulin gene. Subsequent generations of transgenic tilapia will undergo a program of genomic optimization selecting for growth, survival, and fecundity as well as stability of the transgene. Islets from the resulting transgenic fish, after extensive characterization, could be harvested, encapsulated, and then transplanted into diabetic patients.
Keywords: Key words: Islets of Langerhans; Xenotransplantati
Document Type: Review Article
DOI: http://dx.doi.org/10.3727/000000001783986864
Affiliations: 1: *Departments of Pathology, Biomedical Engineering, and Surgery, Izaak Walton Killam Health Centre, Dalhousie University Faculty of Medicine, 5850 University Ave., Halifax, Nova Scotia, Canada B3J 3G9 2: †Department of Biology, 5076 Life Sciences Bldg., Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
Publication date: February 1, 2001
More about this publication?
- Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication charge, which is dependent on the number of pages, in addition to the charge for color figures. This will allow work to be disseminated to a wider audience and also entitle the corresponding author to a free PDF, as well as prepublication of an unedited version of the manuscript.


text: QC APPROVED: [Plus] [PK Gaming] [TRC] GP APPROVED: [Electrolyte] [] Rotom-H Overview ######## Rotom-H has usually been regarded as a lesser Rotom-W, mostly due to its weakness to Stealth Rock and less useful STAB combination. In addition, as a Fire-type, Rotom-H faces immense competition from Heatran as well, which boasts a much better defensive typing and offers far more flexibility in its support options. However, Rotom-H does have its merits. It possesses eight resistances and one immunity, compared to Rotom-W's six, and has a Fire-type STAB attack that destroys many of Rotom-W's usual counters. Certain threats alike are handled much better by Rotom-H than by Rotom-W, including Talonflame, Mega Pinsir, Mega Charizard Y, Thundurus, Aegislash, Ferrothorn, Mega Mawile, and Mega Venusaur. In comparison to Heatran, Rotom-H gains an immunity to the Ground-type moves that destroy Heatran, and handles Water-types much better than Heatran does with a momentum-grabbing Volt Switch. Keep these niches in mind and you'll find a Pokemon that is neither outclassed nor overshadowed by anything else. Defensive ######## name: Defensive move 1: Overheat move 2: Volt Switch move 3: Will-O-Wisp move 4: Pain Split / Rest ability: Levitate item: Leftovers / Chesto Berry nature: Bold evs: 252 HP / 252 Def / 4 SpD Moves ======== Despite Rotom-H's defensive nature, Overheat remains its main STAB move of choice to threaten most of the Pokemon it counters. Volt Switch provides momentum and switching utility; with Rotom-H's greatly increased longevity, more opportunities to use Volt Switch will arise. Will-O-Wisp cripples many of the attackers that might try to switch into Rotom-H, such as Garchomp and Tyranitar. Finally, Pain Split is one of two choices Rotom-H has for recovery, putting it to decent use with a low HP stat of 50. However, Rest provides a much more thorough form of recovery than Pain Split, particularly in removing the effects of Toxic, at the cost of practically forcing Rotom-H to carry Chesto Berry (and therefore only working reliably once). However, it is also possible to run a second status move in place of recovery. Thunder Wave is better for offensive teams looking to outspeed many of Rotom-H's faster switch-ins, whereas Toxic deals with Rotom-W much more efficiently than Will-O-Wisp does and has better synergy with defensive teams. Set Details ======== A physically defensive spread of 252 HP / 252 Def / 4 SpD lets Rotom-H take on many of the physical attackers it walls, including Talonflame and Mega Pinsir. However, a specially defensive spread is equally viable, allowing Rotom-H to take on attackers like Thundurus and Mega Charizard Y better, and the choice of a spread is really up to what the team needs most. Note, however, that +2 Mega Pinsir can OHKO Rotom-H after Stealth Rock if a physically defensive spread is not used. Leftovers gives Rotom-H a reliable long-term method of recovery, healing chip damage that might be incurred from switching into something it walls and making up for the presence of Stealth Rock in particular. However, if Rest is being used, Chesto Berry is the best option, essentially giving Rotom-H a second chance at life. Usage Tips ======== With a defensive build, Rotom-H can very easily come in on attackers, especially against ones that are already at a severe type disadvantage. Unlike many defensive Pokemon, it can force most of them out, threatening them with one of its STAB attacks or a status move. Because of this, it's essential to have Stealth Rock up on the opponent's side, as many of the Pokemon Rotom-H counters, such as Talonflame and Mega Charizard Y, will be taking massive damage from it. The durability of this Rotom-H makes it very easy for attackers to incur entry hazard damage over the course of a match. Furthermore, prediction against incoming switch-ins is key with this Rotom-H; a timely burn or a smart Volt Switch can easily turn the tide of a battle in your favor. This Rotom-H excels at playing mind games with the opponent, as its wide range of functions and increased utility make it a very relevant defensive threat to many attackers. Team Options ======== Like with the other sets, Rapid Spin or Defog support is crucial, as Rotom-H cannot perform its defensive duties well if it is taking 25% damage each time it switches in. Powerful, hole-punching Pokemon such as Azumarill or setup sweepers such as Calm Mind Landorus love Rotom-H because it is great at reliably gaining momentum throughout the course of a match, presenting offensive Pokemon with great opportunities to set up or attack. In addition, setup sweepers and defensive Pokemon such as Skarmory will also appreciate the reduced damage output from a burned opponent. However, if being used on a defensive team, teammates must be able to handle powerful physical Fire-types such as Mega Charizard X, as they cannot be burnt. Teammates should also be able to handle Pokemon such as Tyranitar that can easily switch in on anything bar Will-O-Wisp and hit Rotom-H for super effective damage. Because Rotom-H handles Talonflame extremely well, Pokemon that are vulnerable to being revenge killed by it will easily appreciate Rotom-H's support. Keldeo is a great teammate in this regard, especially considering it easily takes out Tyranitar, a major threat to Rotom-H. Choice Scarf ######## name: Choice Scarf move 1: Overheat move 2: Volt Switch move 3: Hidden Power Ice / Thunderbolt move 4: Trick / Thunderbolt ability: Levitate item: Choice Scarf nature: Timid evs: 4 HP / 252 SpA / 252 Spe Moves ======== Unfortunately, the inconsistent Overheat is Rotom-H's only Fire-type STAB, and cannot be replaced. However, it is far stronger than any of Rotom-H's other attacks, boosting its viability greatly, and meshes well with this set's hit-and-run nature. Volt Switch is functionally Rotom-H's most important move, as it allows Rotom-H to safely scout the opponent's team and quickly get itself out of a bad situation. Hidden Power Ice gives Rotom-H the ability to revenge kill popular offensive Pokemon such as Garchomp and Landorus, even outspeeding +1 Dragonite thanks to the Choice Scarf. However, its low power means the aforementioned threats will need to have taken some prior damage for a clean OHKO. Thunderbolt, on the other hand, dishes out a much stronger hit than Volt Switch to foes such as Togekiss, as they can otherwise simply recover the damage taken from Volt Switch. In addition, it lets Rotom-H stay in battle with a STAB attack, which Volt Switch and Overheat do not allow. Finally, Trick lets Rotom-H permanently cripple the walls that aim to stop it, namely Chansey and Sylveon. Set Details ======== The given EVs maximize Rotom-H's Special Attack and Speed, the two most important stats for this set's success. A Timid nature lets Rotom-H Speed tie with +1 Rotom-W and outspeed +1 Jolly Dragonite and +1 Adamant Excadrill. A slightly bulkier spread of 108 HP / 176 SpA / 224 Spe with a Timid nature lets Rotom-H survive Choice Band Azumarill's Aqua Jet from full health, and outspeeds Mega Alakazam, Mega Aerodactyl, and +1 Mega Gyarados. If more power is desired, a Modest nature guarantees an OHKO on Dragonite with Hidden Power Ice after Stealth Rock, but keep in mind this prevents Rotom-H from outspeeding all of the aforementioned threats, so it generally isn't worth it. Usage Tips ======== Rotom-H can be brought out against the Pokemon it walls, such Thundurus and Talonflame, taking minimal damage and immediately threatening them. This Rotom-H also functions as a great revenge killer, threatening many popular offensive Pokemon such as Mega Pinsir with one of its STAB or coverage moves after a teammate faints. In addition, Rotom-H functions as an excellent lead, using Volt Switch to gain early momentum. Overheat is usually a powerful move to spam should Volt Switch be a poor choice; however, one must be extremely wary of being locked into Overheat against Heatran or setup sweepers such as Calm Mind Keldeo or Dragon Dance Dragonite. Team Options ======== Due to this set's hit-and-run nature, Rapid Spin or Defog support is crucial to prevent Rotom-H from being worn down. Good Rapid Spin or Defog users to pair with Rotom-H include Empoleon, Latias, Mega Blastoise, Starmie, Tentacruel, and bulky variants of Scizor, as all share decent synergy with Rotom-H. Pokemon with Volt Switch or U-turn can easily form a VoltTurn core with Rotom-H, as it matches well with common users of the strategy such as Landorus and Scizor. Finally, teammates that attract resisted moves or threats such as Ferrothorn or Talonflame are great for Rotom-H, as smart plays will let Rotom-H easily grab momentum with Volt Switch or fire off powerful Overheats. Other Options ######## If Quagsire or the rarely seen Gastrodon and Swampert are a major concern, Hidden Power Grass can be used over Hidden Power Ice, seeing as Rotom-H is such a great lure for these Pokemon. However, this is not recommended because it leaves Rotom-H extremely vulnerable to many Dragon-types, which are more common and more important for Rotom-H to target. Hex is another option Rotom-H possesses, becoming a 130 base power move when the opponent is afflicted with a status condition. Although Rotom-H typically has no trouble inflicting status, its low Speed and lack of STAB on the move discourage the use of Hex, along with the fact that Rotom-H is hard-pressed enough to run more than one status move, let alone another attack. Similarly to Hex, Electro Ball has the potential to work in tandem with paralysis. However, Rotom-H is still held back from its aforementioned faults, along with the fact that some of Rotom-H's most popular switch-ins, particularly Rotom-W and Garchomp, are totally immune. Rotom-H can utilize Sunny Day with Heat Rock to be a reliable, bulky sun setter and abuser that resists and gets STAB on Fire-type moves, is immune to Ground-type moves, and has STAB coverage against Water-types, a combination of traits unexhibited in other sun setters. Rotom-H can also utilize dual screens and a slow Volt Switch to aid its teammates in setting up. Electroweb is a unique option that lets a fully invested Rotom-H outspeed anything under fully invested base 150 Speed. Unfortunately, it is an extremely weak move, and Rotom-H would usually rather switch out with Volt Switch. However, Electroweb can be good for forcing switches, especially if entry hazards are up. Choice Specs allows Rotom-H to punch holes in the opponent's team, but the inconsistency of Rotom-H's STABs are simply not worth the extra power. Finally, Rotom-H can use Assault Vest to become an even more effective special tank. However, a complete lack of recovery coupled with a Stealth Rock weakness is extremely bad for a defensive Pokemon, and the support required to keep Rotom-H alive may not be worth it. Checks & Counters ######## **Special Walls**: Rotom-H can barely touch most special walls, with Toxic being the only somewhat viable option on the defensive set to combat them. However, offensive sets are still hopelessly walled by the likes of Sylveon and Chansey, their best option being Trick (which, in the end, does not prevent them from continuing to be walled.) **Faster Offensive Pokemon**: Non-Choice Scarf variants of Rotom-H must watch out for many of the faster offensive Pokemon that have the typing or coverage to rip Rotom-H apart before it has a chance to move. Nearly anything that Rotom-H doesn't obviously wall will carry something that can hurt it. Greninja, offensive Tyranitar, and Keldeo all fall under this category. **Mold Breaker**: Mold Breaker Earthquake from the likes of Excadrill and Haxorus will absolutely shred Rotom-H, hitting past Levitate. It is extremely important that you look for the telltale "________ breaks the mold!" warning when a possible user is sent out. **Taunt**: Although Taunt by itself is not a huge issue for Rotom-H, and is barely a concern for offensive variants, it can easily prevent defensive Rotom-H from healing or checking sweepers with Will-O-Wisp, which can be extremely problematic. Common users include Thundurus-T, which can potentially muscle through Rotom-H with the aid of Taunt. **Bulky Setup Sweepers**: Bulky setup sweepers, primarily Fire-types such as Quiver Dance Volcarona and Mega Charizard X, will take a pittance from any of Rotom-H's attacks and cannot be worn down without the aid of Toxic.


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The Rider's International Supreme Pony Turnout Sheet helps shield your pony from the rain, wind, and mud. It features a waterproof and breathable Teflon®-coated 1200 denier ripstop outer shell that is woven in a grid pattern to prevent tearing and makes it a great candidate for years of wear! No fill.
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The Pessoa Alpine Turnout Sheet comes with a one-year warranty against tearing. This waterproof and protective turnout features a 1200 denier Ballistic Weave™ fabric that is Teflon®-coated to repel dirt and stains. Extras include a removable tail cover, adjustable leg straps, powder-coated hardware and an ID tag.
Ideal for mild weather, the Amigo® Hero 6 Turnout Sheet from Horseware® Ireland is both waterproof and breathable. It features a tough polyester outer shell and smooth polyester lining. Horseware's classic cut keeps it secure.
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The Amigo® Bravo 12 Turnout Sheet is horse turnout sheet with the Rambo original cut design and Leg Arch™ for freedom of movement. Waterproof and breathable outer shell so your horse stays dry and comfortable.
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From Horseware® Ireland, the Amigo® Bravo 12 Wug Turnout Sheet features the popular high cut neck and V-front closure. This waterproof turnout sheet has a breathable 1200D outer, a smooth lining and no fill. Horseware's classic fit with unique front Leg Arches™ allows for a comfortable fit and freedom of movement.


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We have a beautiful Quarter pony that is in her late teens. She walks and trots and neck reins. Very quiet, very sweet, very easy, very gentle. Gives no…SOLD
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Pretty Palomino Quarter Pony mare. "Barbie" is 8 years old and 56", eligible for registration with all three QP associations. She is spayed so no worries…SOLD


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I've been a developer for over 30 years in one form or another. I learnt Pascal at University and my first job was programming in Fortran 66. I've since moved to C# & .NET via Ada, C and C++.
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"You wasn't wit' me when I was shootin' in the gym!" While Drake made that a very popular line in his verse on "Stay Schemin," he later apologized, and now it seems like he isn't the only person who's sorry. According to TMZ, Kobe and Vanessa Bryant are reconciling their marriage. She appeared at the Valentine's Day Lakers vs. Hawks game in support of the#KobeSystem, which seemingly ended in a victory in more ways than one for the Mamba.
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The book is funny, it's biting and satirical and pointed, yet it never loses its heart. Kyle Beachy manages to be earnest and honest and deeply sad when writing about home and family and finally, really growing up.
The Slide is a story of failed and failing relationships--between husband and wife, father and son, between friends, between lovers. Beachy's protagonist, Potter Mays, is a recent college grad caught in a moment of upheaval. Preoccupied by his dissolving love for his globe-trotting girlfriend, haunted by a dead brother he never really knew, uncertain of how to move on after college, Potter drifts purposelessly through the Missouri summertime making every mistake possible. His character is at once relatable, despicable, pathetic, and honest.
Potter's struggle is a familiar one, but twisted and exaggerated to the point of tragicomedy.
The Slide is impossible to put down--I loved it!
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Beachy's debut novel is the thing of dreams. It is at once lovely and dark, hilarious and very sad. beachy shows great potential and I eagerly await his next generous offering to... Read morePublished on February 25, 2009 by Danny Hatch


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What is a class, an object and an instance in Java?
We started with Q&A. Technical documentation is next, and we need your help.
Whether you're a beginner or an experienced developer, you can contribute.
Java (and any other programming language) is modelled in terms of types and values. At the theoretical level, a value is a representation for some quantum of information, and a type is a set of values. When we say value X is an instance of type Y, we are simply saying that X is a member of the set of values that is the type Y.
So that's what the term instance really means: it describes a relationship not a thing.
The type system of the Java programming language supports two kinds of types, primitive types and reference types. The reference types are further divided into the Classes and array types. A Java Object is (according to the JLS) an instance of a reference type; i.e. either an array or an instance of a Class.
That's the type theoretic view.
In practice, most Java developers treat the words "instance" and "object" as synonyms. (And that includes me then I'm trying to explain something quickly.) And most developers use "value" rather than "instance" to refer to an instance of a primitive type.
A class is a blueprint which you use to create objects. An object is an instance of a class - it's a concrete 'thing' that you made using a specific class. So, 'object' and 'instance' are the same thing, but the word 'instance' indicates the relationship of an object to its class.
This is easy to understand if you look at an example. For example, suppose you have a class
The class
Note: This is exactly the same in Java as in all object oriented programming languages.
A class is basically a definition, and contains the object's code. An object is an instance of a class
for example if you say
the class is the String class, which describes the object (instance) word.
When a class is declared, no memory is allocated so class is just a template.
When the object of the class is declared, memory is allocated.
I like Jesper's explanation in layman terms
By improvising examples from Jesper's answer,
myHouse and myCar are objects
myHouse is an instance of House (relates Object-myHouse to its Class-House) myCar is an instance of Car
in short
"myHouse is an instance of Class House" which is same as saying "myHouse is an Object of type House"
Class is Data Type,You use this type to create object.
mustafabar's answer is good, but based on the beginner level of the question (no offence meant, I was a beginner once, too) I'd recommend some reading up. Here is a good place to start. http://java.sun.com/docs/books/tutorial/java/concepts/
In java, the objects are spawned on heap memory. These require reference to be pointed and used in our application. The reference has the memory location of the object with which we can use the objects in our application. A reference in short is nothing but a name of the variable which stores the address of the object instantiated on a memory location.
For Example,
For the above code snippet, ref is the reference for an object of class A generated on heap.
If you have a program that models cars you have a class to represent cars, so in Code you could say:
someCar is now an instance of the class Car. If the program is used at a repairshop and the someCar represents your car in their system, then your car is the object.
So Car is a class that can represent any real world car someCar is an instance of the Car class and someCare represents one real life object (your car)
however instance and object is very often used interchangably when it comes to discussing coding
Any kind of data your computer stores and processes is in its most basic representation a row of bits. The way those bits are interpreted is done through data types. Data types can be primitive or complex. Primitive data types are - for instance - int or double. They have a specific length and a specific way of being interpreted. In the case of an integer, usually the first bit is used for the sign, the others are used for the value.
Complex data types can be combinations of primitive and other complex data types and are called "Class" in Java.
You can define the complex data type PeopleName consisting of two Strings called first and last name. Each String in Java is another complex data type. Strings in return are (probably) implemented using the primitive data type char for which Java knows how many bits they take to store and how to interpret them.
When you create an instance of a data type, you get an object and your computers reserves some memory for it and remembers its location and the name of that instance. An instance of PeopleName in memory will take up the space of the two String variables plus a bit more for bookkeeping. An integer takes up 32 bits in Java.
Complex data types can have methods assigned to them. Methods can perform actions on their arguments or on the instance of the data type you call this method from. If you have two instances of PeopleName called p1 and p2 and you call a method p1.getFirstName(), it usually returns the first name of the first person but not the second person's.
The concept behind classes and objects is to encapsulate logic into single programming unit. Classes are the blueprints of which objects are created.
Here an example of a class representing a Car:
You can create instances of the object Car like this:
I have taken the example from this tutorial
The definition "Object is an instance of a class", is conceptually wrong, but correct as per implementation. Actually the object oriented features are taken from the real life, for focusing the mind of programmer from more to less. In real life classes are designed to manage the object.For eg- we human beings have a caste, religion,nationality and much more. These casts, religion, nationality are the classes and have no existence without human beings. But in implementation there is no existence of objects without classes. Object- Object is an discrete entity having some well defined attribute. Here discrete mean something that makes it unique from other. Well defined attribute make sense in some context. Class- Classification of object having some common behaviour or objects of some common type.
While the above answers are correct, another way of thinking about Classes and Objects would be to use real world examples: A class named Animal might contain objects like Cat, Dog or Fish. An object with a title of Bible would be of class Book, etc. Classes are general, objects are specific. This thought example helped me when I was learning Java.