text:
Again National Rental Car did an outstanding job. The staff was friendly and professional, the car I picked out was clean and ready to go. I do have a complaint- At the time of picking up my car the agent informed me that National Rental Car will be putting a $300 hold on my card. This was in addition to the rental charges. This charge was for all Michigan drivers. When I turned the car in, I asked about this charge and was told this is done to encourage local drives to rent cars from other locations than the airport. NRC wants to maintain their fleet of cars for out of town guests and business travelers. If this is the policy going forward, then the local Enterprise locations, need to do a better job of being open on the weekends, and supplying vehicles. I support the auto industry and when I travel, I need a specific Make of vehicle. I certainly can't drive a Chrysler to a GM plant, or a GM to a Ford plant. Enterprise can't guarantee any make or model when making a reservation. It is best effort only. The make of vehicle may not be available with a local office that has a much smaller inventory of cars. Finally, the airport NCR is the only location in the Detroit Metro area. My rating is for the local staff and service they provide.
Southwest Detroit Dollar Rent A Car
Save A Buck Rent A Car
25713 John R Rd, Madison Heights, MI 48071
- (248) 876-3239
Alamo Rent-A-Car
Serving the Detroit area.
- (800) 362-2725
61. Enterprise Rent-A-Car
They have great staff that provides great customer service and the manager Sara will make sure everything is to your liking
62. Enterprise Rent-A-Car
I had to drive to a friend's house about 4 hours away, and was afraid that my little car wasn't going to get me there and back. So, I decided to ren…
63. Enterprise Rent-A-Car
The employees were very polite & professional. This the only rental company & location I rent cars from.
64. Avis Rent A Car
1 star because the car & the price were okay, but the customer service was EXTREMELY HORRIBLE. There was only 1 person in front of me when we arrive…
65. Enterprise Rent-A-Car
21811 Allen RdWoodhaven, MI 48183
From Business: Pick Enterprise. We'll Pick You Up.®
66. Enterprise Rent-A-Car
11375 Middlebelt RdRomulus, MI 48174
67. Enterprise Rent-A-Car
23780 West RdBrownstown Twp, MI 48183
68. Enterprise Rent-A-Car
29301 Grand River AveFarmington Hills, MI 48336
69. Main Car Rental & Service, Inc.
829 N Main StRoyal Oak, MI 48067
70. Choice Car Rentals
24111 Telegraph RdSouthfield, MI 48033
71. Midtown Rental Car
24111 Telegraph RdSouthfield, MI 48033
72. Enterprise Rent-A-Car
Great staff courteous and efficient.
73. Hertz Local Edition - Car Rental
Hertz ferndale is the best car rental in the area. I have had the pleasure of using Hertz Ferndale several times and with each experience has bee…
74. Enterprise Rent-A-Car
23300 Gratiot AveEastpointe, MI 48021
From Business: Pick Enterprise. We'll Pick You Up.®
75. Avis Rent A Car
2225 West RdTrenton, MI 48183
76. Budget Rent A Car
27364 Woodward AveRoyal Oak, MI 48067
77. Budget Rent A Car
34500 Plymouth RdLivonia, MI 48150
78. Affordable Rental Car
29551 Greenfield RdSouthfield, MI 48076
79. Enterprise Rent-A-Car
Easy to deal with people. Very often I get a free upgrade. Best weekend prices out there.
80. Enterprise Rent-A-Car
This location had the best staff! We rented for a driving vacation sinice our vehicles were old. They were friendly and extremely helpful. The vehi…
81. Enterprise Rent-A-Car
Greatest car rental place!! So helpful, courteous , knowledgable. Will never rent anywhere else!!
82. Enterprise Rent-A-Car
Picking up the rental was quick and friendly. Very nice SUV, smooth ride, absolutely no complaints. Returning the rental was also quick and friendly…
83. Enterprise Rent-A-Car
I love enterprise but if u reserve a car for one price but when u go pick it up after 2 months it's a another price that's not who I want to do busi…
84. Enterprise Rent-A-Car
26520 Greenfield RdOak Park, MI 48237
From Business: Pick Enterprise. We'll Pick You Up.®
85. Enterprise Rent-A-Car
30674 Woodward AveRoyal Oak, MI 48073
From Business: Pick Enterprise. We'll Pick You Up.®
86. Enterprise Rent-A-Car
19251 Mack AveGrosse Pointe Woods, MI 48236
87. Avis Rent A Car
27364 Woodward AveRoyal Oak, MI 48067
88. Avis Rent A Car
34500 Plymouth RdLivonia, MI 48150
89. Ace Rent A Car
7788 Merriman RdRomulus, MI 48174
90. Enterprise Rent-A-Car
22180 W 8 Mile RdSouthfield, MI 48033
The National program, Emerald Club, is a very good program as I like to close my car. The Detroit National location at best is mediocre.bCars are always dirty. Windows never clean inside or out. Always some sort of trash still in the car. I use them as I like to pick the type of car I drive. Hertz does a much better job of providing a clean car. Nationals point program is also on the weak side as it takes a full year of renting almost every week to get enough free days for a vacation rental. Also, their promotion 1-2-Free never appears on your statement you have to call to see what you have earned and you can't combine it with other free days earned. I understanding is free however almost better not to offer if it inconveniences the customer. Lastly I am executive elite with National. Doesn't mean much. Everyone who gets off the bus in Detroit gets to pick any car in any aisle, even executive rows, if a member of the Emerald Club. But if you are hung up on picking the type of car you want to drive, like me, you use National n
I use National rental car as part of my company's preferred car rental service and am an emerald club member. All of my rentals thus far have been good, except for the last time out of Detroit (at DTW). I rented a car that was clean but had a very strong and unpleasant odor. It may have been that a customer smoked in the car but I should have noticed that at a late night pickup of a rental, with this car being the only car left out of all mid-size sedans, there was something negative about it and people were staying away for a reason. This was a rental that I had to keep the windows slightly open while highway driving to keep from becoming ill. For vehicles like these, I would prefer for National to take them out of the rotation until the they could be further cleaned. Overall, National has been a good provider of rental cars for me and makes the process near seamless (i.e., straight from the shuttle bus to the car and on return, from the car to the shuttle bus... no office visit required).


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The behaviour of participants in electricity markets is complex and is more appropriately studied as an economic game rather than as an optimisation problem. In this paper, a co-evolutionary approach has been developed to study the dynamic behaviour of participants over many trading intervals. Each market participant is represented by a trading agent. The bidding strategy of each agent is modelled as a set of bidding actions, one for each possible discrete state of the state space observed by the agent. Trading agents co-evolve their own populations of bidding strategies using a Genetic Algorithm. Simulation results have shown that in this competitive environment, participants can learn to improve their trading profit and the proposed state-based bidding strategy can help facilitate this learning process.
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|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|"Guillaume Nodet (JIRA)" <j...@apache.org>
|[jira] Commented: (SM-716) EIP pattern to re-route the flow in case of an error / fault.
|Fri, 06 Apr 2007 18:51:35 GMT
[ https://issues.apache.org/activemq/browse/SM-716?page=com.atlassian.jira.plugin.system.issuetabpanels:comment-tabpanel#action_38976 ] Guillaume Nodet commented on SM-716: ------------------------------------ While answering on another thread on the user list, I thought we could make this component (an error-handler) quite pluggable. Instead of simply re-routing the exchange to another service, the endpoint could be given a strategy for handling exchanges in error. The simple re-routing could be one of the strategy, but more complex ones could be written too: for example a redelivery with an exponential back off and a DLQ target service ... > EIP pattern to re-route the flow in case of an error / fault. > ------------------------------------------------------------- > > Key: SM-716 > URL: https://issues.apache.org/activemq/browse/SM-716 > Project: ServiceMix > Issue Type: New Feature > Components: servicemix-eip > Affects Versions: 3.0 > Reporter: Charles Souillard > > There has been several requests for such a component to re-route > the flow in case of an error / fault. An EIP pattern is the best way > to go imho. -- This message is automatically generated by JIRA. - You can reply to this email to add a comment to the issue online.
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Courtyard By Marriott Pleasanton
Courtyard By Marriott Pleasanton
Hotel Guest Rating: 8.1/10
5059 Hopyard Rd
Pleasanton, CA 94588
Hotel Freebies Available*
• Free Internet in Room show dates
• Free Parking show dates
Welcome to the Courtyard By Marriott Pleasanton
Located 20 miles from Oakland Airport, the non-smoking Courtyard by Marriott Pleasanton has a cafe, a 24-hour market and free internet access.
Hotel Features
Each of the 145 rooms in the three-story Courtyard by Marriott Pleasanton includes satellite TV, a coffeemaker and a sofa bed. The Bistro serves breakfast and dinner, evening cocktails and specialty drinks made with Starbucks coffee. Guests can enjoy a refreshing dip in the outdoor pool. There is an on-site gym featuring cardio equipment and free weights. Laundry facilities are available, and parking is free. NOTE: The hotel will be undergoing roof repairs from August 29 to September 16, 2016. Loud noise is possible during work hours.
Hotel Location
The hotel is 20 miles from Waterworld USA, four miles from Las Positas Golf Course and 14 miles from the Oakland Zoo. The Oakland International Airport is 17 miles from the hotel.
Guest Favorites
Priceline guests enjoy the "quiet location," "comfortable rooms," "convenient" Pleasanton location that's "right off the freeway" and the "great amenities" at the Courtyard by Marriott Pleasanton.
Courtyard By Marriott Pleasanton Amenities
- 24-hour front desk
- Accessible facilities
- Accessible parking
- Air conditioning
- Air conditioning individually controlled in room
- Alarm clock
- AM/FM radio
- Baby sitting
- Business center
- Business services
- Cable television
- Check cashing policy
- Child programs
- CNN available
- Coin operated laundry
- Color television
- Complimentary in-room coffee or tea
- Complimentary newspaper in lobby
- Connecting rooms
- Direct dial telephone
- Dry cleaning
- Efolio available to company
- Elevators
- ESPN available
- Exercise gym
- Express check-out
- Fitness center on-site
- Food and beverage outlets
- Free high speed internet connection
- Free parking
- Free toll free calls
- Front desk
- Full service housekeeping
- Gym
- Hairdryer
- HBO available
- Health club
- High speed internet access
- High speed wireless
- Housekeeping - daily
- Ice machine
- Individual Efolio available
- Interior corridors
- Iron
- Ironing board
- Laundry/Valet service
- List of movie channels available
- Local calls
- Lounges/bars
- Meeting rooms
- Non-smoking
- Non-smoking rooms (generic)
- On-site business center
- On-Site parking
- Onsite laundry
- Outdoor pool
- Outdoor space
- Parking
- Pool
- Public area air conditioned
- Remote control television
- Restaurant
- Room service - full menu
- Safe deposit box
- Security
- Telephone
- Valet cleaning
- Valet same day dry cleaning
- Voice mail
- Wakeup service
- Wireless internet connection in public areas
Hotel Information
Upon check-in photo identification and credit card is required. All special requests are subject to availability upon check-in. Special requests cannot be guaranteed and may incur additional charges. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Courtyard By Marriott PleasantonOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
Sort by: All Travelers | Business Traveler(7) | Solo Traveler(6) | Traveling as Couple(12) | Family with Young Children(1) | Family with Teens(2) | Senior Traveler(1) | Group Traveler(1)
Joseph from Lemon Grove, CA
May 24, 2016
May 24, 2016
This guest did not leave comments about this hotel.
Elise from Paradise, CA
May 23, 2016
Senior Travelers
May 23, 2016
Senior Travelers
Beautiful setting, clean rooms, comfortable beds, friendly staff.
Verified Hotel Guest from Seal Beach, CA
May 17, 2016
Solo Traveler
May 17, 2016
Solo Traveler
Bar inside lobby.
No spa
Verified Hotel Guest from Atwater, CA
May 2, 2016
Business Traveler
May 2, 2016
Business Traveler
This guest did not leave comments about this hotel.
Verified Hotel Guest from Rye, NH
April 27, 2016
Family Traveling with Teens
April 27, 2016
Family Traveling with Teens
The pool courtyard area was clean, quiet, a pleasant place to relax with morning coffee.
Although the king bed was comfortable, the pullout couch was miserably uncomfortable, with a lumpy, thin, painful mattress. And I was charged an extra $40 to have a third person in this room! No sleep for him....
Verified Hotel Guest from Los Angeles, CA
April 18, 2016
Solo Traveler
April 18, 2016
Solo Traveler
the room was convent to your car and had easy access to your car because every room and it was very secure because you needed a hotel key to get thru secured doors to get to your room
Teresa from Clovis, CA
April 18, 2016
April 18, 2016
This guest did not leave comments about this hotel.
Verified Hotel Guest from Anthem, AZ
April 13, 2016
April 13, 2016
Verified Hotel Guest from Woodland, CA
March 14, 2016
March 14, 2016
Great size and layout. Very happy with the room.
Sodas / Candy / Chips were expensive!
Verified Hotel Guest from Garden Grove, CA
October 18, 2015
Solo Traveler
October 18, 2015
Solo Traveler
That it was clean
Very nice!
Reviews of Courtyard By Marriott Pleasanton
(1 - 10 of 32 reviews)
(1 - 10 of 32 reviews)
from $149
- Extended Stay America Pleasanton - Chabot Dr. from $98 (0.2mi)
- Four Points By Sheraton Pleasanton from $184 (0.2mi)
- Hyatt House Pleasanton from $159 (0.2mi)
- Motel 6 Pleasanton from $98 (0.2mi)
- Best Western Plus Pleasanton Inn from $110 (0.4mi)
- Cheese Steak Shop (0.2mi)
- El Balazo (0.3mi)
- El Balazo (1.1mi)
- Romano's Macaroni Grill (1.1mi)
- Baja Fresh Mexican Grill (1.2mi)
- Callippe Preserve (4.6mi)
- Dublin, CA (5.7 mi)
- Livermore, CA (7.7 mi)
- San Ramon, CA (11.6 mi)
- Danville, CA (14.8 mi)
- Fremont, CA (15.6 mi)
- Castro Valley, CA (16.2 mi)
- Hayward, CA (16.8 mi)
- Union City, CA (18.9 mi)
- Newark, CA (19.6 mi)
- Milpitas, CA (20.2 mi)
- San Leandro, CA (21.8 mi)
- Walnut Creek, CA (22.4 mi)
- Alviso, CA (23.7 mi)
- Pleasant Hill, CA (25.3 mi)
- Lafayette, CA (25.8 mi)
- San Jose, CA (26.2 mi)
- Santa Clara, CA (26.7 mi)
- Concord, CA (28.3 mi)
- Alameda, CA (29.4 mi)
- Sunnyvale, CA (29.9 mi)
- Brentwood, CA (29.9 mi)
Most Popular Guest-Rated Hotels in Pleasanton
Most Popular Business-Friendly Hotels in Pleasanton
Most Popular Romantic Hotels in Pleasanton
- Pleasanton Marriott
- Residence Inn By Marriott Pleasanton
- Doubletree By Hilton Hotel Pleasanton At The Club


text:
Dear Readers : Panchabuta has been offline since December 2015, the longest ever since we started publishing daily, a consequence of the Chennai Floods, which devastated our offices and homes. We have since, gotten back during this time. The support I received during this phase and the encouragement to restart after this difficult setback is something for which I will be eternally grateful to those behind me. We have crossed many significant milestones and been a resource to the industry ... Read More »
Category Archives: Other
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According to reports, the launch of an unprecedented international solar alliance in Paris on the sidelines of the climate change summit shows India's leadership in clean energy, environmental experts here have said. "This unprecedented international solar collaboration sets an encouraging tone as country representatives gather today to reach a new global climate agreement. India's leading role in forming an International Solar Alliance anchors its own climate commitment to ramp up renewable energy," said Rhea Suh, president of the Natural Resources ... Read More »
Solar rooftop systems subsidy will remain at 30%
According to reports, solar rooftop systems will continue to be subsidized by 30%, despite the Union ministry of new and renewable energy (MNRE)'s June announcement of hacking it by half. Industry experts are not thrilled about the decision, citing state incompetency in doling out the subsidy on time, possibility of poor quality products from suppliers while leaving manufacturing costs unchanged. The recent announcement from the ministry mentions that the subsidy comes under the Central Financial Assistance (CFA) scheme and is ... Read More »
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According to reports, Hero Future Energies, ReNew Power and Reliance Cleangen are evaluating the renewable energy portfolio of Welspun Enterprises. Welspun Renewables, wholly-owned green energy arm of Welspun Enterprises, is selling equity stakes in its solar and wind power projects. SoftBank, earlier keen to pick up stakes in the projects, has dropped out. Welspun Renewables was raising capital through equity sales, said a person close to development. Persons in the know said domestic and foreign companies were in the fray ... Read More »
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According to reports, twenty countries, including India, the US and China, will launch an initiative to double their clean energy research and development budget over the next five years as part of global efforts to tackle climate change. The total amount of money being committed by these 20 countries – under Mission Innovation — amount to USD 20 billion, about half of which would come from the US, White House officials said. A formal announcement of the initiative is expected ... Read More »
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According to reports, Prime Minister Narendra Modi is set to launch his ambitious International Solar Alliance on Monday, the first day of the Paris climate summit. The move is being seen by analysts as a strategic step for the country on the global stage. Experts say that the alliance, which would include around 50 African countries, would be a huge business opportunity for Indian companies. It is also likely to give the country a leadership role in solar power-generation capacities. ... Read More »
Solar sunrise
According to reports, solar power tariffs have hit a new low. US-headquartered SunEdison's winning bid of ₹4.63 a kWh for a 500 MW project in Andhra Pradesh, has evoked comparisons with the e-commerce industry, where critics have mockingly dubbed the business model as 'scale-up and trust to luck'. It has also deepened the cleft between the believers and cynics, with the former pointing out that as long as two years back, global renewable energy consultancy GTM Research had predicted solar ... Read More »


text:
Aikido Kokikai South Everett
Jennifer Payne
Bugsie Productions
This is the best one ever. Mr. Personality is the owner and he loves his job.
Vote: DJ
They know how to make it fun.
Vote: Wedding DJ
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text:
Alternative Vote Plus
Alternative Vote Plus
AV+ has yet to be put into practice anywhere in the world.
How does the Alternative Vote Plus work?
The Alternative Vote Plus (AV+) uses the Alternative Vote (in which voters rank candidates in order of preference) to elect a candidate in each constituency, and then uses a small top-up list to make the overall result more proportional.
Voters can either select their favourite party or choose their favourite candidate from the top-up list and the votes are then allocated to represent each party's share of the votes proportionally
Pros and cons of the Alternative Vote Plus
|The case for AV+
|The arguments against
Elected MPs would have the support of a majority of their local electorates.
All existing constituency boundaries would have to be redrawn.
Being able to rank candidates increases voter choice, as does having both a constituency vote and a regional vote.
Ballot papers would be more complicated than First Past The Post ones.
Nearly every elector would have at least one vote that would have an effect on the overall election result.
It creates two classes of representative, which could create animosity between them and a confusion of roles.
Parties would have an incentive to campaign across the whole country, and not just in the marginals.
The final result will be fairer, with parties having a share of MPs based on their support among the electorate, rather than on electoral arithmetic and geographical oddities.
AV+ will produce majority governments when the voters express a desire for one, but will force them to work together when the electorate choose not to give any one party a clear majority.
Tactical voting would no longer be necessary.
Voting Systems
|Proportional Representation
|Mixed Systems
|Majoritarian Systems
|More representative as seats are distributed according to vote share.
|Combines the features of majoritarian-style systems and Proportional Representation.
|Systems that are highly disproportional.
|Single Transferable Vote
|Additional Member System
|First Past the Post
|Party List PR
|Alternative Vote Plus
|Alternative Vote
|Borda Count
|Block Vote
|Limited Vote
|Supplementary Vote
|Two-Round System


text:
Top Definition
When the words "white trash" just aren't enough.
She bought two of those sling things for her kids so she could breastfeed both at the same time. Very white landfill, if you ask me.
Por Haydoom 26 de julio de 2009
Trending Now
Los emails se envían desde firstname.lastname@example.com. Nunca te enviaremos spam.×


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Relevant offers
A friend stayed the other night and we got to talking, on the second anniversary of the Canterbury quakes, about some of the less immediate but profound fallout from this national tragedy. And how that fallout was predicated upon our tolerance of "risk".
OPINION: Think about it this way, he said. Every year, several hundred people die on our roads. We could reduce that number immediately by making everybody drive the safest proven cars - C-series Mercedes, for example. Further, we could reduce the speed limit and raise the driving age.
By imposing unrealistic, antisocial and unpalatable conditions, we could significantly reduce one of this country's biggest perennial killers.
Without wishing to diminish the tragedy and anguish brought to a city and its inhabitants by the terrible earthquakes of September 2010 and February 2011, and the death of 185 people, these events have heightened, in some cases, to an absurd extent, our national sensitivity to chance. We have become deleteriously "risk averse".
My friend, who has had a high- end career in civil engineering and project management, often of major public building complexes, thinks it's bonkers. There is risk in everything we do. It is striking the right balance that is the trick, and the legacy of the Canterbury quakes may have been to put the chance register right out of kilter.
By the time it resettles, for example, we may have lost the great bulk of our unreinforced masonry buildings across all our towns and cities, and along with them, the majority of our built heritage - despite the fact that the single largest contributor to the toll, the CTV building, belongs to the modern era.
I'm no expert in insurance, reinsurance, underwriting and building regulation, but I take his point. And the more general one that we need to inject a little sanity into the debate over risk assessment and liability.
Should we really abandon our stone and masonry churches all over the country because there is some minuscule possibility that one day, there could be a significant seismic event which might, in certain circumstances, endanger lives? The smart money might be inclined to look at the science and suggest that those churchgoers, unless they were driving C-Series Mercedes within an urban 50kmh zone, were much more likely to be killed on their way to the service.
While the insurance industry and governments have a considerable role to play in this conundrum, personal choice and individual responsibility have a part, too. Just as they do in a variety of lifestyle choices. One shouldn't have to be told, for instance, that drinking 10 litres of Coca-Cola a day could be injurious to your health. Or that smoking causes cancer.
On the latter, I'm with Tariana Turia. Even if one accepts that people should be free to gauge the health risks of their own actions, the consequences of smoking and associated impost on the public purse, are punitive.
If Turia achieves little else in her little remaining time in Parliament, her championing of the legislation to push for plain packaging on cigarettes and loose tobacco will be a fitting achievement on which to sign off. Further, there is little political risk attached to an initiative that restricts seductive advertising of a product that is highly addictive and leads to a variety of fatal diseases.
The same cannot be said for the hole that Prime Minister John Key and his Government seem to be getting into over the pokies-for- convention-centre issue. The auditor-general's report has been widely canvassed as providing the Government with a "get-out-of- jail-free" card. But, as we all know, that conclusion cannot be used to either justify or excuse the shonky processes, underscored in the report, that underpinned a SkyCity deal preferentially spruiked by the Government.
Last week in Parliament, buoyed no doubt by the ostensible conclusion, Key was still digging. Far from hitting paydirt, he simply raised further eyebrows about his personal involvement in the deal when he categorically stated, and later retracted, that SkyCity had offered to buy TVNZ land in Auckland, when in fact, they had done no such thing. Did he get a little ahead of himself?
Beyond the all-important probity in process, what's really at stake here, what's in the balance? A tourism-boosting convention centre against a proliferation of poker machines known to be the source of misery for vulnerable individuals?
Notwithstanding the requirement that people take responsibility and assess the financial and social risks of their own addictions, nor Gambling John's predisposition to cut high- stakes deals, it is a potentially risky political proposition.
- Fairfax Media
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Nashville, TNUSA
Hometown: Nashville
March 4, 2014
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My name is Nancy. I am a Naturalist at Bowie Nature Park in Fairview and I love to hike whenever I get the chance.
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Used to describe a situation in which things turn out good.
Dude 1, "I think I'm going to hired for that new job I applied for."
Dude 2, "safe"
Dude 2, "safe"
dari noname Minggu, 27 Juni 2004
Safe can be used if someone gave you sum ting or done someting for you,you can also use it as a thank you & when ur leaving someone or somewhere you can say safe.you can use it as good-bye.Safe.the word safe can be used in 3 terms
dari Aneil Kamis, 01 Maret 2007
what the pitcher yells when the player is on the bag, in this case high on bag of crystal meth. when a person is obviously tweaking you call them "safe" on the bag.
look at the skinny lady - she's safe! look at her twitch and jaw jack!
everyone is safe at the walmart
everyone is safe at the walmart
dari boombie Kamis, 08 Maret 2012
Safe is an english word which is used to represent somebody who is a person that can be trusted and will have your back - it will be used in other texts but they are not correct.
Oi seckle this is my bredrin, hes safe, seckle!
dari Pau Kamis, 03 Februari 2005
a word that chavs use to say Hello.
"safe man"
"safe mate"
"safe mate"
dari nottz gyaldem Sabtu, 04 Oktober 2008
Safe = good, sorted, done!
person 1: hey, ive just txted sophie..shes on her way..
person 2: safe!
person 2: safe!
dari india111 Jumat, 27 Juli 2007


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If you're one of the many people out there who are still asking whether or not weight loss supplements work, then you're not alone. The easiest and simplest way to lose weight is through weight loss pills – the reason why hundreds, even thousands of products are found in the market.
But not all weight loss products are made the same – most of them contain harsh ingredients that may work, but also gives you drastic side effects that are just not worth it.
The new generation of weight loss products are made with the right formulation using the right ingredients, so you get to enjoy natural and effective weight loss without the nasty side effects.
The most vocal and most popular supporter of this new generation of weight loss products is Dr. Oz – the most prominent doctor on TV today. Using the latest research and findings in the scientific world, the doctor has continuously and consistently recommended the use of weight loss products that are safe, natural, and truly effective.
It is important to note that Dr. Oz does not promote any specific brand of supplements, he merely recommends them based on the large amount of scientific data found on the top weight loss natural supplements.
The Top 3 Weight Loss Products Recommended by Dr. Oz
Dr. Oz supports the use of these next generation of weight loss products: HCG, Forskolin, and Garcinia Cambogia.
Forsolin – Forskolin is an extract taken from the roots of the plant called Coleus Forskohlii. It is a member of the mint family and found on the mountain slopes of the regions of Nepal, India, and Thailand.
Forskolin has long been used in several medications for asthma, high blood pressure, and even skin disorders. Scientists recently found out that it has an incredible ability to melt fat found in the belly area – leading Dr. Oz to name Forskolin extract as "lightning in a bottle," and "rapid belly melt." It can also help in giving you lean muscle growth, reduce body fat, and increased levels of energy.
HCG – HCG stands for Human Chorionic Gonadotropin, which is a hormone produced in the placenta of pregnant women. Available as injections or drops, and in conjunction with a daily 500-calorie diet, HCG has an incredible ability to help you lose up to 1 lb. a day!
HCG changes the way your body reacts to low calorie diets – giving you your much needed energy so you won't feel weak or hungry throughout the day, despite consuming very little amounts of food.
Garcinia Cambogia – The most popular and most recommended weight loss product by far, garcinia cambogia has become the go-to supplement for many users for its incredible ability to make you lose weight even without the help of diet or exercise.
Understanding Garcinia Cambogia
Garcinia Cambogia is a fruit found in the regions of Southeast Asia where it has long been used as a flavoring agent to dishes. It also has an amazing ability to make dishes more filling.
When scientists started studying the extract of this incredible fruit, they discovered that the rind contains massive amounts of HCA or Hydroxycitric Acid. This compound is the very reason why garcinia cambogia as a supplement is so effective in helping you lose weight fast!
It naturally has the ability to suppress your appetite and prevents the formation of fat!
But is it really effective? A study found on the website of the US National Library of Medicine National Institutes of Health proves its incredible natural weight loss abilities.
A Scientific Study Proving Garcinia Cambogia's Effectiveness
A study done by Downs, BW, and others was conducted in 2005, where they combined HCA with natural minerals potassium and calcium. Their study led to their findings that when these 3 ingredients are combined, the results on the body are the following: increased thermogenesis, increased energy, increased lipid metabolism, increased serotonin, reduced appetite, reduced hypertension, and reduced body weight!
This led to Downs, BW and his group of researchers to conclude that HCA is a potential solution to get rid of unwanted and excess weight in the body.
How Garcinia Cambogia Works
HCA is the core ingredient of garcinia cambogia supplements and it works in 2 incredible ways:
These 2 incredible amazing mechanisms make garcinia cambogia a dual-acting natural supplement that targets the very cause of weight gain!
Garcinia Cambogia Slim Fast – The Best Selling Natural Weight Loss Product
With thousands of satisfied users around the world, Garcinia Cambogia Slim Fast has become the most trusted name in garcinia cambogia weight loss supplements.
Made with 100% natural ingredients, it stands out as a leading product in the market due to the following reasons:
Contains 1000mg in every capsule – double the industry standard of 500mg
Contains potassium and calcium to boost metabolism
Garcinia Cambogia Slim Fast does not only meet the industry standards, it sets itself apart by going the extra mile to give you a truly unique, natural, and incredible effective solution to beat fat and lose excess weight.
Getting Your Supply of Garcinia Cambogia Slim Fast
This product is exclusively sold online, so head to the official website today and take your pick from these 3 budget-friendly packages to get started:
Get started with your weight loss journey by visiting the official website and getting your supply of Garcinia Cambogia Slim Fast. Because garcinia cambogia is a dosage-based weight loss solution, the more you use, the more weight your lose!
And backed with a 30-day guarantee, get your full money back without question if you are not happy with the results. Start using Garcinia Cambogia Slim Fast today and get to enjoy your best body ever in as little as 4 weeks!


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Telephone & Addresses
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Kimberly Price, 51, Aransas Pass, W Stapp Ave
View Kimberly Joann's social profiles and photos on Facebook, MySpace, and +40 Networks.
Kimberly Price, 55, Cedar Falls, College St
View Kimberly Joann's social profiles and photos on Facebook, MySpace, and +40 Networks.
Kimberly Price, 73, Detroit, Forrer St
View Kimberly Joann's social profiles and photos on Facebook, MySpace, and +40 Networks.
WhitePages: Joann Price in CT | Whitepages
39 matches for Joann Price in Connecticut. Find Joann Price's phone, address, etc. on Whitepages, the most trusted online directory."
Yellow Page contacts
Ms. Kimberly Price - Attorney in Savannah, GA - Lawyer.com™
Kimberly Price is an attorney in Savannah, GA. Find out lawyer Kimberly Price's state bar license status, years in practice, phone and address information.
Ms. Joann Price - Attorney in Merrillville, IN - Lawyer.com™
Joann Price is an attorney in Merrillville, IN. Find out lawyer Joann Price's state bar license status, years in practice, phone and address information.
Law Offices Of Joann M. Price - Merrillville, IN - Lawyer.com
Law Offices Of Joann M. Price is a law firm in Merrillville, IN. - Lawyer.com />
Network Profiles
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LinkedIn: Kimberly Price | LinkedIn
View Kimberly Price's professional profile on LinkedIn. LinkedIn is the world's largest business network, helping professionals like Kimberly Price discover inside
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3M Announces New Leadership Appointment | Business Wire
3M announced today that Kimberly F. Price has been appointed to the position of senior vice president, Corporate Communications and ...
Kimberly Price / EyeEm Pictures | Getty Images
View of Deer And Kid On Grassy Field. Find premium, high-resolution photos at Getty Images.
Kimberly Price - NJ Track and Field Profile - Athletic.net
Kimberly Price - NJ Track & Field results and photos on Athletic.net.
Kimberly Price - Stats - NJ MileSplit
Kimberly Price. Monmouth University West Long Branch, NJ, USA. Is this you? Follow · Search for Athlete · Compare Athletes. Total Results 62; Total Events 6.
Business Profiles
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Joann Price - Secretary for Price Asset Management, Inc.
Secretary for Price Asset Management, Inc. Joann Price is currently associated with one company, according to public records. The company was incorporated ...
Kimberly Price | Rice Energy Inc. | ZoomInfo.com
"This is the first year we have planned such an event, and we're thrilled with the positive feedback we've received so far," said Kimberly Price, external ...
Kimberly Price Hicks (Lexington, SC, 29072) - Family ...
Book now with Kimberly Price Hicks of Lexington, SC. Read patient reviews and ratings, and make an appointment online, instantly. View insurance networks ...
Kimberly Price | McKinney TX | Keller...
Kimberly Price ... Phone: 972-562-8883 Mobile: 469-877-7484
Private Homepages
Piper High School - Kimberly Price
Class of 2018 Graduation Requirements. Class of 2019 Graduation Requirements. Kimberly Price. Teacher. Enter your Name: E-mail address: Message Subject ...
(1 - 4 from 7
BOARD OF TRUSTEES | Amistad
JoAnn Price, President Emeritus Emilie de Brigard, Vice President Pamela McKoin, Vice President Ellen Nurse, Vice President Cynthia Williams, Vice President
Senior Staff - Manor Park - The Village at Manor Park
Assistant Health Care Administrator Social Worker. Stephen Nelson Administrator for Healthcare. Joann Price, CPA Chief Financial Officer. Donna Robertson
Kimberly Price at Hickey College - RateMyProfessors.com
Rating and reviews for Professor Kimberly Price from Hickey College St. Louis, MO United States.
Teachers | Los Niños Primero
Kimberly Price. Teacher. Kimberly began working in the school as a paraprofessional. During her seven years as a paraprofessional, she was awarded Fulton ...
(1 - 4 from 133
ratemyteachers: Kimberly Price - Hickey College | RateMyTeachers.com
Kimberly Price from Hickey College in St. Louis, Prince Edward Island (MO) is on RateMyTeachers.com. Rating Kimberly Price helps students and parents of ...
classmates: Kimberly Price
Summerville Union High School, Tuolumne, CA, 1978-1982
classmates: Kimberly Price
Juliet W. Long Elementary School, Gales Ferry, CT, 1974-1978
classmates: Kimberly Price
Hall High School, West Hartford, CT, 1977-1981
Celebrities & Politicians
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IMDB Filmography: JoAnn Price - Biography - IMDb
It looks like we don't have any Biography for JoAnn Price yet. Be the first to contribute! Just click the "Edit page" button at the bottom of the page or ...
IMDB Filmography: Kimberly Price - IMDb
Kimberly Price, Actress: Modern Girls in Traditional Ties. ... Contribute to IMDb. Add a bio, trivia, and more. Update information for Kimberly Price ».
Bad news
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legacy.com: KIMBERLY PRICE
Kimberly Price, 49, Kansas City, MO, passed away May 22, 2012. Services 11 a.m. Wed., May 30 at Wornall Road Baptist Church, 400 W. Meyer Blvd. Visitation 9-11 a.m. Burial Forest
legacy.com: Kimberly Price
Kimberly Price Virginia - Kimberly Koren Price was born 07/24/1975. The Lord called Kim home on 12/13/2015. Kim is survived by her parents Hazel Ball & William Price, her four
legacy.com: JoAnn Price
ASHLAND - JoAnn Price, 73, died Sunday. Funeral 11 am Wednesday, Miller Funeral Home. Visitation 6-9 pm Tuesday at the funeral home. Visit Legacy.com
findagrave: Price, JoAnn
03/12/1935 - 03/12/1935, Wetzel County, West Virginia
(1 - 4 from 14
JoAnn Price (deceased) - Genealogy - Geni
Genealogy for JoAnn Price (deceased) family tree on Geni, with over 140 million profiles of ancestors and living relatives.
Kimberly Price - Free Death & Obituary Records
Research Kimberly Price's Death Records, We're 100% Free! First Name. Middle Name. Last Name. City. State ... 57 Death Records for. Kimberly Price ...
Joann Price Obituary - Liverpool, NY | Syracuse Post Standard
Joann Brown Price December 2, 2015 Joann Brown Price, 62, of Liverpool, went to be with our Lord on Wednesday afternoon. Born in Cortland ...
Scanned Document - FamilySearch
From "The Avants," by JoAnn Price Surls, Madonna Price Lane, Tony Mac Price, and Terry Price Shelton, in. Family Histories of Henderson County, Texas ...
Joann Price - Homes.com
... Contact Homes.com; Homes.com Corporate Site. Real Estate Agents > Arizona > Bullhead City · Search. Agent: JoAnn Price, BULLHEAD CITY, AZ ...
JoAnn Price - Real Estate Agent - Tri-State Realty
JoAnn Price - real estate agent - Tri-State Realty. Find more information about JoAnn Price on The Real Estate Book.
Joann Price Real Estate Agent in Saint Charles, MO | Homes.com
Homes.com - The world's best real estate web site of homes, real estate, realtors, and homes for sale. Find real estate agents, mortgage loans and rates, home...
Joann Price - O'Fallon, MO Homes For Sale | HomeFinder.com
Connect with Joann Price on HomeFinder.com. See homes for sale, property photos, neighborhood details, and virtual tours.
Books & Literature
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Joann Price (Author of Martha Stewart) - Goodreads
Joann Price is the author of Barack Obama (0.0 avg rating, 0 ratings, 0 reviews, published 2008), Barack Obama (0.0 avg rating, 0 ratings, 0 reviews, pub...
A Purse of Your Own: An Easy Guide to Financial Security
When JoAnn Price graduated from Howard University, married an attorney, adopted two of her sister-in-law's children, gave birth to a child, and continued ...
Black Enterprise - Aug 1995 - Page 118 - Google Books Result
JoAnn Price really knows how to bring in the cash. During her 12 years as president of the National Association of Investment Co., a Washington-based trade ...
Black Enterprise - Jun 1995 - Page 238 - Google Books Result
"I'm glad I'm in front of that train instead of behind it," says JoAnn Price, president of Fairview Capital Partners. Fairview Capital L.P., a subsidiary, is one ...
Related Documents
Kimberly Price Sheet C04-2014.xlsx - AFD - Cal Poly
Freedom Chair with Arms. Freedom Chair with Arms. $399.00. $659.00. $561.00. Liberty Chair with Arms. World Chair with Arms. $570.00. $508.00.
Kimberly Price's Library | Photobucket
Kimberly Price's Library. 25 photos.
Video & Audio
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Kimberly Price - Associate Degree In Accounting on Vimeo
This is "Kimberly Price - Associate Degree In Accounting" by ashworthcollege on Vimeo, the home for high quality videos and the people who ...
Kimberly Price - YouTube
Search Channel. All activities. Uploads; Likes; Playlist additions. Kimberly Price subscribed to a channel. Jason Woods. SubscribeSubscribedUnsubscribe 2K ...
Kimberly Price on Vimeo
Kimberly Price is a member of Vimeo, the home for high quality videos and the people who love them.
Joann Price | C-SPAN.org
March 22, 2011 Venture Capital and Start Up Companies. Treasury Secretary Geithner moderated a panel on challenges facing small businesses, government regulation, and ...
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Brazil Times: Local News: Corporation honors retiring bus drivers ...
23.05.2008 [Click to enlarge]. The Clay Community Schools Corporation Transportation office conducted its annual fish fry Friday while also honoring two retirees. Joann Price and Bonnie Graham both will retire this year following years ...
Obituary for Kimberly Price Whitecotton, of Sherwood, AR
KIMBERLY PRICE WHITECOTTON, of Sherwood, was born in Little Rock to Willis (Dutch) and Judy Price, March 12, 1969 and blessed our ...
Spotlight: Kimberly Price | Pittsburgh Sun Times
Spotlight: Kimberly Price. Written By Pittsburgh Tribune-Review Posted: 01/10/2016, 04:00am. Her co-workers at Rice Energy Inc. found that out during a kickball ...
Kimberly Price (Earth-616) - Marvel Database - Wikia
Kimberly Price Real Name Kimberly Price Base Of Operations New York State Status Identity No...
Reports & Statements
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Fantasy & Sci fi art by Kimberly Price Riley - Elfwood
Kimberly Price Riley. I update as often as I'm able. I've removed all of the Keeper stories for the time being. A lot in the universe has changed since I first started ...
Board of Directors - Apollo Theater
JoAnn Price. Jonelle Procope. Lisa Garcia Quiroz. Marcus Samuelsson. Debra Shriver. Earl W. Stafford. Leslie M. Uggams. Bronson Van Wyck. Pharrell Williams.
Kimberly Price Edmisten, Lenoir City Council. - Discussion on Topix
Kimberly Price Edmisten, Lenoir City Council. Posted in the Lenoir Forum. Leave a Comment Track Replies. Comments. 1 - 5 of 5 Comments ...
Kimberly Price | The Mentoring Partnership of Minnesota Blog
Posts about Kimberly Price written by wendyrmpmn.
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JoAnn H. Price: Executive Profile & Biography - Businessweek
Ms. JoAnn H. Price is a Co-Founder of Fairview Capital Partners, Inc. and serves as its Managing Partner. Ms. Price has been with Fairview since September 1, ...
Run Kimberly Run | Kimberly Price's Fundraiser - Crowdrise
Hi!! My name is Kimberly Price. I like to call myself a Wellness Mama, Multi-Passionate Entrepreneur and Holistic Health Coach, whose biggest claim to anything ...
Kimberly Price & Matthew Niebuhr - Wedding Registry
Kimberly Price and Matthew Niebuhr from Clayton, CA have registered at Crate and Barrel, Macy's and Target for their wedding on October 10, 2015. Browse all ...
About your coach Kimberly Price - refresh
Hello, my name is KIMBERLY PRICE and my biggest claim to anything great is being the mother of four children. They keep me busy at all times, but constantly ...
Hugo Elementary School - About Kimberly Price
Elementary Campus > Special Education > Kimberly Price >. About Kimberly Price. This is my 27th year to teach. It is my 22nd year here at Hugo Schools.
Kimberly Price (@urchokj) • Instagram photos and videos
See Instagram photos and videos from Kimberly Price (@urchokj)
Kimberly Price's (kimprice) software portfolio · Devpost
Kimberly Price is a Mobile Developer specializing in JavaScript, Java, iOS, Ruby on Rails, Python, and C++. Follow Kimberly Price on Devpost!
Spotlight: Kimberly Price : Related Articles | OOYUZ
Kimberly Price recently was appointed manager of external communications at Rice Energy Inc. She first joined the Rice Energy team in ...
That baby's dead, honey.: Kimberly Price knew something ...
At age 19, Kimberly Price was raising a 2-year-old son and living with her mother at the family's home in Southeast. The two women did not get ...
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KIMBERLY PRICE IS ONE OF THE DRIVING forces behind the marvelous designs we see from Coach, a leading American designer of luxury ...
Kimberly Price - KITR - Montgomery County Road Runners ...
Kimberly Price – KITR. email@example.com|. Upcoming Events. There were no results found. Upcoming Events. Fri 25. Back of the Pack. September 25 ...
Kimberly Price and Stephen Price's Baby Registry on The ...
Kimberly Price & Stephen Price's Registry. Due Date: Apr 03, 2016 | Location: Canton, GA. Kimberly Price has shared a baby registry with you! See what ...
Las Vegas, Nevada, Usa. 18th Sep, 2015. Kimberly Price ...
18th Sep, 2015. KIMBERLY PRICE warms up before competing in the Pro Powerlifting Championships during Joe Weider's Olympia Fitness and Performance.
Joann Price - maurer funeral home, inc.
This is the permanent online memorial and Life Legacy for Joann M. Price. Please join us in Loving, Sharing and Memorializing, through stories ...
JoAnn Price Named Woman of the Year By The Village for ...
The Village for Families & Children's 2014 Woman of the Year award will be presented to JoAnn Price, co-founder and managing partner of ...
JoAnn Price is WH Champion of Change | The Hartford ...
WASHINGTON, DC – At the Wilson-Gray YMCA, JoAnn Price has helped to develop a truly remarkable Youth Achievers Program, helping ...
National Relay 2015: Kimberly Price - Carry The Load
I am participating in the Carry The Load National Relay this year. By supporting me, you are joining in the mission to restore the true meaning of Memorial Day.
JoAnn H. Price - Connecticut State Colleges & Universities
Share on Twitter · Share on Facebook · BOR Members. JoAnn H. Price. Ms. Price is a co-founder and managing partner of Fairview Capital Partners, Inc., ...
Kimberly Price (Kent State University) | EDUCAUSE.edu
EDUCAUSE Annual Conference October 25–28, 2016. Submit to Present! Conferences & Events. Annual Conference · EDUCAUSE Connect Events
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kimberly-price Hi! My name is Kimberly and I am the owner of Move and Groove Fitness. I have over 15 years of dance experience, I am a certified group fitness ...
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7 Reviews
Great marinade. I added 1/3 cup applebutter, fresh onion slices and fresh minced garlic. Marinated overnight. I pan seared the tenderlion and finished it off in the oven. This is a keeper recipe.
Made for football pool wildcard weekend playoff
Tip the plate scrumptious. The marinade came together in a snap and a half batch was plenty for my one pound pork tenderloin. I marinaded overnight for about 20 hours. Used my favorite cooking technique to prepare the meat, searing it first in a cast iron skillet before popping the full skillet into a 450 degree oven for 15 minutes. In this case, I included cubes of sweet potatoes, butternut squash and chunks of vidalia onions, and put about 1/4 of the marinade in the skillet. At the same time I simmered the remaining marinade. The vegetables roasted perfectly and absorbed much of the flavor imparted (not to mention some beautiful caramelization due to the sugar content of the apple jack). Once cooked, I added the marinade to the pan while the meat rested. The combination with the roasted vegetables was fabulous, but the onions were truly over the top and something I would consider a requisite (so much so I would even make them separately in said manner). Served with steamed asparagus and my tastebuds were in rapture. Thanks mikekey for an easy but divine meal.
Wonderful marinade! I used it on 2 boneless chicken breasts so I cut it down in half. Marinated overnight and baked it in the oven. Flavorful and very tender. I'm eating leftovers today for lunch. YUM! Made for I Recommend Tag Game 2013.
What a great marinade and tenderizer!!! I used this on a small pork tenderloin and let it marinade for 8 hours and then we grilled it, and we did brush on the marinade to help get a nice char on the outside. It was so tender on the inside, about melted in my mouth. I think this is a 2nd or 3rd time I have used Jack Daniels in a marinade and just love the results. I served it with fried rice and green beans for one tasty dinner. Thanks for sharing the recipe. Made for you win in the football pool.
Great marinade for pork! I used these on a couple of thick pork chops, marinating for about 6 hours, then pan-searing and finishing in the oven. Apples and pork are a great combination and this marinade brought those flavors together beautifully. Looking forward to using this on a pork roast cooked on the grill - thanks for sharing the recipe!
I made a quarter recipe of the marinade for about a pound of pork, and it was plenty. It was good - and definitely tastes like Jack Daniels!
What a great marinade I used it on pork chops, the only change I made was I used 3 tablespoons fresh minced garlic in place of the powder and increased the olive oil to 1/4 cup, thanks for sharing Mikekey, will make again!


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Death in Genoa
With each demonstration the fences go higher, the security forces swell, the gear gets more sinister, the weapons deadlier. Each time, beneath the pleas for peace, the rage is ratcheted up another notch. In Genoa, where some 100,000 anti-corporate-globalization demonstrators massed last week, there was, inevitably, a victim. An Italian police officer shot 23-year-old Carlo Giuliani point-blank, once in the forehead, once in the left cheek, as he hoisted a fire extinguisher toward the officer's Land Rover. La Repubblica called him a Christ figure with arms splayed upon the asphalt. Corriere della Sera countered, saying he was an anarchist provocateur. But Giuliani is not the first to die demonstrating against neoliberal economic policies. Recently, activists have been killed in Papua New Guinea, Nigeria, Bolivia, and elsewhere. The police are ready to kill to keep order. Are demonstrators prepared to die to be heard? Lenora Todaro
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Dennis Farina Dead at 69
By Dustin Rowles | Miscellaneous | July 22, 2013 | Comments ()
Dennis Farina died in Scottsdale, Arizona from — what TMZ is calling — a blood clot in his lung. He was 69.
A character actor most known for cops and robbers roles over his 32 year career is probably best known to today's generation for his role on Law and Order, and more recently, as Nick Miller's Dad in "The New Girl." A former Chicago police officer of nearly 20 years, Farina excelled at the the Chicago everyman, and had stand-out roles in Get Shorty, Snatch, and Saving Private Ryan. He also served as host of Unsolved Mysteries after Robert Stack passed away.
He will be missed.
Pajiba Love Express
Here's some Daveed Diggs for you. On Daveed Diggs' digs, actually. That man does things with clothes that should not make sense, but are absolutely perfect. (Go Fug Yourself)
Woody Allen has "so moved on" from his daughter's accusations and says he never even thinks about it. He equates her words about him to a bad review he won't read and comments on how wacky it is that Mia Farrow is his mother-in-law. He is the worst. (Celebitchy)
Not The Worst but still very gross: Leonardo DiCaprio and his
Here are 5 under-the-radar shows. I had never even heard of the first two. (Uproxx)


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Short Communication
Functional compartmentalisation of NF-κB-associated proteins in A431 cells
Version of Record online: 14 FEB 2013
DOI: 10.1002/cbin.10053
© 2013 International Federation for Cell Biology
Cell Biology International
Volume 37, Issue 4, pages 387/a–396/a, April 2013
Additional Information
How to Cite
Bolshakova, A., Magnusson, K.-E., Pinaev, G. and Petukhova, O. (2013), Functional compartmentalisation of NF-κB-associated proteins in A431 cells. Cell Biology International, 37: 387/a–396/a. doi: 10.1002/cbin.10053
Publication History
- Issue online: 11 MAR 2013
- Version of Record online: 14 FEB 2013
- Accepted manuscript online: 24 JAN 2013 05:56AM EST
- Manuscript Accepted: 10 JAN 2013
- Manuscript Received: 17 OCT 2012
- Abstract
- Article
- References
- Cited By
- A431 cells;
- actin cytoskeleton;
- EGF and fibronectin stimulation;
- RelA/p65;
- sub-cellular fractionation
NF-κB proteins belong to a family of ubiquitous transcription factors involved in a number of cellular responses. While the pathways of NF-κB activation and input into the regulation of gene activity have been comprehensively investigated, its cytoplasmic functions are poorly understood. In this study we addressed effects of the compartmentalisation of NF-κB proteins RelA/p65 and p50 in relation to the inhibitor IκB-α, using fibronectin (FN) and epidermal growth factor (EGF) for environmental stimulation of epidermoid carcinoma A431 cells. We thus assessed the presence of NF-κB family proteins in the cytosol, membrane, nuclear and cytoskeletal fractions with a special attention to the cytoskeletal fraction to define whether NF-κB was active or not. Sub-cellular fractionation demonstrated that the proportion of RelA/p65 differed in diverse sub-cellular fractions, and that the cytoskeleton harboured about 7% thereof. Neither the nuclear nor the cytoskeleton fraction did contain IκB-α. The cytoskeleton binding of RelA/p65 and p50 was further confirmed by co-localisation and electron microscopy data. During 30-min EGF stimulation similar dynamics were found for RelA/p65 and IκB-α in the cytosol, RelA/p65 and p50 in the nucleus and p50 and IκB-α in the membrane. Furthermore, EGF stimulation for 30 min resulted in a threefold accumulation of RelA/p65 in cytoskeletal fraction. Our results suggest that nuclear-, membrane- and cytoskeleton-associated NF-κB are dynamic and comprise active pools, whereas the cytoplasmic is more constant and likely non-active due to the presence of IκB-α. Moreover, we discovered the existence of a dynamic, IκB-α-free pool of RelA/p65 associated with cytoskeletal fraction, what argues for a special regulatory role of the cytoskeleton in NF-κB stimulation.


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Click here to print the obituary below
Ray F. Hodsdon
Ray F. Hodsdon
BERWICK, Maine - Ray F. Hodsdon, 71, of Berwick, died early Tuesday morning, September 10, 2013 after a lengthy illness. He was born in Roxbury, Maine on July 2, 1942, a son of Philo and Alice (Taylor) Hodsdon. He was raised in Frye and a 1960 graduate of Stephens High School in Rumford, Maine. After graduation he enrolled in the Machinist Apprentice Program at the Portsmouth Naval Shipyard, beginning a 35 year career as a Machinist and Design Engineer. During this time he met his wife of 47 years Elaine Kimball. Early in his career, he enlisted and served in the
He was a longtime member of the Lions Club, and in his spare time enjoyed antique cars, fishing, woodworking and camping.
He was predeceased by his first wife Elaine Kimball Hodsdon in 2010, two brothers, Douglas Hodsdon in 2000 and Roy Hodsdon in 2006 and brother-in-law Robert Kimball 2012.
Survivors include his son Andrew and wife Tamara Hodsdon of Berwick, Maine; his grandchildren Alexander and Jillian Hodsdon of Berwick; second wife Nancy (Diamant) Kimball of Berwick, a brother Roscoe and wife Lorrie Hodsdon of Frye, Maine, sister-in-law Earlene Rosenberg of Bryant Pond, Maine, Karen Hodsdon of Frye Maine, and many nieces, nephews, and cousins.
There are no calling hours. A Graveside Service will be held on Saturday, September 21, 2013 at 11 a.m. at Evergreen Cemetery, Berwick, Maine. Should friends choose, memorial donations in his memory may be made to: Another Chance Animal Rescue PO Box 552, North Berwick, Maine 03906
Arrangements are in care of Laing-Bibber Funeral Chapel, 36 Rochester Street, Berwick, Maine 03901
for an online guest book.
Funeral Home
Laing-Bibber Funeral Chapel
36 Rochester Street
Berwick, ME 03901
(207) 698-1105
Published in Fosters from Sept. 17 to Sept. 20, 2013


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The all-new 2016 Audi TT Roadster makes a bold first impression. The broader Singleframe grille creates a stronger, sportier face with LED headlights that are inspired by the focused eyes of an athlete. The most enviable feature is the power retractable acoustic soft top. Make the most of the warm weather and starry nights at the push of a bottom, plus enjoy a smoother ride with the electrically adjustable wind deflector. Lying in wait under the hood is the culmination of years of motorsport innovation and engineering – a powerful 2.0 litre TFSI engine with 220 hp and 6-speed S-tronic dual-clutch transmission that propels the Audi TT from 0 to 100km/h in only 5.9 seconds.
The 2.0 TFSI engine produces 220 hp, offering impressive power and efficiency. The sprint from 0 to 100 km/h is effortless, taking just 5.9 seconds, and its top speed is electronically limited to 250 km/h.
The elegant interior of the Audi TT Roadster further complements the impressive exterior, with numerous sophisticated details, including uniquely crafted aluminum inlays. The newly redesigned air conditioning controls, now artfully integrated into the air vents, provide additional style, as well as more intuitive climate control.
Embodying innovation at its best, the brand new, driver-focused Audi virtual cockpit is a fully digital instrument cluster that puts all necessary information directly in front of the driver's eyes via a high-resolution 12.3-inch LCD screen. To further complement this technology, the unique, multi-function steering wheel allows the driver to operate various functions without ever taking hands off the wheel.
Highly efficient and stylish, the Audi LED headlights provide high-precision illumination for an exceptional night driving experience, and greater safety on the road.


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Native American Forum: Walking The Red Road
Powwow Time
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This discussion is public.
Original Post
It is getting nice here in Beautiful Colorado and soon all over it will be Powwow time. It has been Powwow time in Florida for many months. I sure miss all of those wonderful ones from when I lived there.
I am making many beautiful shoulder dusters to match shawls, 6 - 8 inches. If anyone is in need of any please just drop me a line. You can read my feedback and see that my work is top notch.
Pilamaye Ye
Posted at 3:14 pm Mar 13, 2012 EDT
Cindi...good luck.
Let's use this thread to announce Pow Wow's and/or other events in our areas and/or those we plan to attend.
In Omaha. Patrick and I will be vending.. I would guess that Night Owl Market will be there as well.
Creighton University Pow Wow....April 14
University of Nebraska at Omaha....April 28
Posted at 7:43 am Mar 14, 2012 EDT
Denver Colorado ... 38th Annual Denver March PowWow
Denver Coliseum
March 23-25, 2012
Posted at 2:50 pm Mar 14, 2012 EDT


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Video: Iowa CF Eric Toole makes an incredible diving catch
Big Ten fans have seen several tremendous plays on the diamond this past week.
Watch Tuesday's Big Ten Football Media Days live on BTN TV or click here to watch via BTN2Go at 8 a.m. ET.
Big Ten fans have seen several tremendous plays on the diamond this past week.
BTN Student U
Big Ten baseball fans were treated to an incredible play on Tuesday when Ohio State third baseman Nick Sergakis made an outstanding stop down the line and threw out a runner from one knee.
Ohio State baseball topped Louisville 2-0 on Tuesday night on a game on BTN/BTN2Go, and Buckeyes third baseman Nick Sergakis' play in the second inning was an eye-catching part of the win. Watch Sergakis dive to snag the hot smash down the line and throw the runner out from one knee.
It was a busy day of Big Ten baseball Saturday afternoon, including a half-dozen conference games.
In a game that was scoreless heading into the 15th inning, Nebraska's Austin Darby stepped to the plate and delivered.
Austin Darby has made a living out of making highlight-reel grabs during his Nebraska career.


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Miami's 2009 season ended with a loss, and the 2010 campaign isn't off to a great start either.
Running back Graig Cooper could miss all of next season because of a severe right knee injury, a person briefed on an initial diagnosis told The Associated Press on Wednesday. The person spoke on condition of anonymity because of school policies about revealing injury information.
Cooper was hurt Tuesday when his knee gave way after a misstep on slippery turf late in the first half of Miami's loss to Wisconsin in the Champs Sports Bowl. He led the Hurricanes (9-4) with 695 yards rushing this season, and his 2,218 career yards places him No. 5 on Miami's list.
Now, there's a strong chance he won't play again until 2011, although more tests are planned to determine the exact nature of the injury and develop a timetable for surgery.
"It's very bad," the person said after some members of the team returned to Coral Gables, Fla., on Wednesday morning.
Cooper will undergo an MRI on Thursday, but he has been told that he likely tore his anterior cruciate ligament, his father told the Palm Beach Post on Wednesday.
"We won't know how bad it is until they take the tests," Tino Thomas, Cooper's father, said, according to the newspaper.
On the play that featured the injury, Cooper picked up a short kickoff at the Miami 24, burst through a hole and seemed poised for a long runback. Near midfield, he planted his knee in what players described as sandy turf -- large divots appeared in the surface all game long -- and the joint gave out. Cooper collapsed quickly, squeezing his knee tightly with both hands.
He was not available to reporters after the game.
Cooper was considering turning pro for the 2010 season, as were a number of other Miami juniors, including top wide receiver Leonard Hankerson, left tackle Orlando Franklin and defensive lineman Allen Bailey.
Hankerson said Tuesday night that he's coming back. Franklin has long said he's certain to return, and Bailey's mind isn't totally made up but he's also leaning toward playing his senior season.
All that news represents significant victories for Miami's hopes for 2010, and could soften the blow of Cooper's injury.
"That's key," defensive back Brandon Harris said. "Hankerson and Allen Bailey, they were great playmakers on our team. They made the big plays when we needed them. ... Just to have those guys around, with their experience and their leadership ability, that's going to go a long ways toward carrying this team."
Aside from the rocky finish, it was an improved season for Miami.
The Hurricanes were 5-7 in 2007, Randy Shannon's first year as coach. Miami improved to 7-6 last year, then added two more wins to the total this season, Jacory Harris' first as the Hurricanes' full-time starting quarterback.
"The next level we've got to get to, I guess, is finishing the season strong, just learning how to finish," said Jacory Harris, who has an injured thumb and is looking forward to having time to heal. "That's something that we got to put into our minds during the offseason by telling ourselves, you know, in everything we do, just finish. Hopefully that will carry over into the season."
By then, Shannon likely will have a new contract. But the process could take a while.
Shannon's deal expires at the end of next season, and athletic director Kirby Hocutt told The Associated Press on Wednesday that getting an extension signed "is a priority in the coming days and weeks."
The sides have been talking, at least informally, for more than a year, and it's believed Shannon's representatives made a request for a three-year extension with a modest raise several weeks ago, then got a counteroffer involving less money in return. Miami also wants to extend offensive coordinator Mark Whipple's deal, which actually could occur before Shannon's new deal gets hashed out.
For his part, Shannon sees signs that a return to championship form is getting closer.
"I'm proud of these guys for what we've been through for my last three years, you know, getting some guys in this program to believe that we can turn it around," Shannon said. "The first year was difficult. The second year was a little stress because we played so many young guys, like Jacory and these young sophomores that we got. This year, they stepped up."
In a very quiet locker room Tuesday night, players vowed that would continue.
"This is the University of Miami. I didn't come here to win nine games," Franklin said.
Said Brandon Harris: "This will probably be the most intense offseason that any other class at the University of Miami has had. ... We really want to go undefeated next season and win a national championship. That's going to start this offseason."
Information from The Associated Press was used in this report.


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