text:
This action might not be possible to undo. Are you sure you want to continue?
Grade Level: 8-9
Lesson Objectives: - The student will be able to create and solve equations from real life problems. Ohio Standards, Benchmarks, and Grade Level Indicators Benchmarks: Patterns, Functions and Algebra, 8-10 D. Use algebraic representations, such as tables, graphs, expressions, functions and inequalities, to model and solve problem situations. H. Solve systems of linear equations involving two variables graphically and symbolically. Grade Level Indicators (Grade 8) Patterns, Functions and Algebra (Use 7. Use symbolic algebra (equations Algebraic Representations) and ineqalities), graphs and tables to represent situations and solve problems. Patterns, Functions and Algebra (Use 8. Write, simplify and evaluate Algebraic Representations) algebraic expressions (including formulas) to generalize situations and solve problems. NCTM Content Standards and Process Standards Alignment NCTM Content Standards: Algebra (9-12) -Write equivalent forms of equations, inequalities, and systems of equations and solve them with fluency-mentally or with paper and pencil in simple cases and using technology in all cases. -Use symbolic algebra to represent and explain mathematical relationships. NCTM Process Standards:
Problem Solving -Solve problems that arise in mathematics and in other contexts. -Apply and adapt a variety of appropriate strategies to solve problems. Connections -Recognize and use connections among mathematical ideas. -Recognize and apply mathematics in contexts outside of mathematics. Materials, Technology, and Resources Three different worksheets with real life amusement park related questions. Smart board is used to write down directions for the amusement park activity. Lesson Procedures (Launch, Explore, Share/Summarize) A. Launch (10 min) Start off class by telling students that today will be an activity day. Explain that there are three stations with worksheets related to real life situations at an amusement park. Tell students to get into groups of 3 or 4. All group members must write answers down to the worksheet on a separate sheet of paper. The first station is where the students solve problems about ticket prices to get into the amusement park. The second station deals with buying food, drinks, t-shirts, and pictures at an amusement park. The third station involves the wait time for rides, and calculating the speed of certain roller coasters. The order of the stations does not matter. All groups must go to each station by the end of class. Give students ten minutes for each station's worksheet. B. Explore (30 min) Let students get started on the worksheets. Walk around to answer any questions on the worksheets. Tell students when ten minutes has passed for all three stations. This helps keep students on track with completing the three stations. Ask students, " What information does the problem give you to start with?" Also can ask, " What was the first step you used to solve this question?" Another question the teacher could ask is "What are you trying to find/solve for in this question?" "What does a certain equation represent in the problem?" Have students show their work used in solving the problems. Make sure students are using correct equations when trying to solve the problems.
C. Share / Summarize (10 min) Ask students "How did you solve the problems in each station?" Hopefully students created equations from the information given in the problem and then solved the equations for the right variable. Go over any questions the students have on any of the worksheets. No homework assignment for the students. Student Summative Assessment Students will turn in their work for each of the three station's worksheets. The teacher will grade these worksheets to measure the students understanding. Students will eventually take a test that will have a couple word problems. They will need to be able to create and solve equations in order to get all of the points for the questions. Differentiation / Accommodations I will provide students with disabilities with a copy of each worksheet if needed. All materials will be accessible to these students. ELL students will be placed in appropriate groups in order to help with expressing ideas on paper. Place them in groups with students who are willing to help and work together. Homework Options and Home Connections: No homework for students. References:
This action might not be possible to undo. Are you sure you want to continue?
We've moved you to where you read on your other device.
Get the full title to continue listening from where you left off, or restart the preview.


text:
Plz ladies help me my baby is refusing to take the bottle and am trying to wean her due to medical issues ... Do u have any ideas to help me in that issue , plus she is not gaining weight , she only gained one lb in 3 months although I started her on solids as her ped recommended but still it's not helping with her weight issue ... Did any of experience that with their babies ?
Posted 02/24/2013
Comments (9)
Posted 02/24/2013
Just keep trying. Offer the bottle early and give baby time to figure it out. She will get it. Have faith.
Posted 02/24/2013
We were finally able to get my LO to take a bottle. It took 8 weeks. Try the MAM bottle with a flat nipple. You can find them at walmart. Also, don't force the bottle. If they won't take it, try again later. It just takes time and a lot of patience.
Good luck!
Good luck!
Posted 02/24/2013
I'm sorry you have to stop bfing. :( It took weeks and several different bottles before ds got the hang of it. Tommee Tippee is what worked for us. Instead of jamming the nipple in his mouth, I gently tapped or rubbed it on his lower lip. I tell dh that ds has to think it's his idea and that seems to make it easier for both. I hope this helps--good luck!
Posted 02/24/2013
I agree with mer1206. Try teasing the side of their mouth with the nipple. Their natural rooting reflex should help them to turn towards it and take it.
Posted 02/24/2013
Try lots of different kinds. My LO only takes the latex nipple. She also wants a very warm bottle.
Posted 02/24/2013
I want to add that you shouldn't be the one offering the bottle to start out with. Try to completly distance yourself. Leave the house all together and have someone else offer the bottle. Good luck!
Posted 02/24/2013
My LO will take one bottle for a day or two, then refuse it, but will take a differant type. He's ebf and doesn't get bottles often but try switching them up.
Learn more
Look how far your child has come.
Review your child's growth milestones.
Read about 3 years 8 months : Week 2.
Your growing child
Your 3 1/2-year-old: Read it again!
Why your preschooler wants to read the same book again…and again. Read More
Your 3 3/4-year-old: Getting silly
Is there any happier sound in the world than your child giggling uncontrollably? Read More
Your 3 3/4-year-old: Computer ready?
Do 3-year-olds need to use computers? Read More
Your 3 3/4-year-old: Coordination
If your child can't do some physical things that her peers can, should you worry? Read More
Your 3 3/4-year-old: Language play
What sounds like nonsense coming from your preschooler's lips is actually a sophisticated kind of language experimentation. Read More
Learn more
What's next for your growing child?
Get a glimpse of what's to come.
Read about 3 years 10 months.

subset: commoncrawl


text:
Preliminary results from this study were presented at the Annual Congress of the European Veterinary Emergency and Critical Care Society (EVECCS), in Cambridge, UK, June 2010. The manuscript represents a portion of a thesis submitted by the first author at the Universitat Autònoma de Barcelona, as partial fulfillment of the requirements for her PhD program, supervised by the corresponding and the last authors.
Association of Admission Plasma D-Dimer Concentration with Diagnosis and Outcome in Horses with Colic
Version of Record online: 14 OCT 2010
DOI: 10.1111/j.1939-1676.2010.0618.x
Copyright © 2010 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 24, Issue 6, pages 1490–1497, November/December 2010
Additional Information
How to Cite
Cesarini, C., Monreal, L., Armengou, L., Delgado, M.Á., Ríos, J. and Jose-Cunilleras, E. (2010), Association of Admission Plasma D-Dimer Concentration with Diagnosis and Outcome in Horses with Colic. Journal of Veterinary Internal Medicine, 24: 1490–1497. doi: 10.1111/j.1939-1676.2010.0618.x
Publication History
- Issue online: 3 NOV 2010
- Version of Record online: 14 OCT 2010
- Submitted April 9, 2010; Revised August 5, 2010; Accepted August 31, 2010.
- Abstract
- Article
- References
- Cited By
- Coagulopathy;
- isseminated intravascular coagulation;
- Equine;
- Gastrointestinal disease;
- Prognosis
Background: Coagulopathies detected in horses with gastrointestinal problems seem to be associated with poor outcome. Plasma D-Dimer concentration is a sensitive test for assessing coagulopathies.
Hypothesis: Plasma D-Dimer concentration tested on admission is related to diagnosis and outcome in horses with colic.
Animals: Four hundred and ninety three horses referred for evaluation of abdominal pain.
Methods: Prospective observational clinical study. Horses were grouped according to diagnosis (medical and surgical intestinal obstructions, ischemic disorders with and without intestinal resection, enteritis, peritonitis), outcome (survivors, nonsurvivors), and number of coagulopathies (normal profile, 1 or 2 coagulopathies, subclinical disseminated intravascular coagulation [DIC]). Blood samples were collected on admission and plasma D-Dimer concentration, clotting times (PT and aPTT), and antithrombin activity were determined. Positive likelihood ratios (LR+) were calculated for evaluation of D-Dimer cut-off values, which were later tested in a logistic regression model.
Results: Horses with enteritis or peritonitis had significantly (P < .001) higher plasma D-Dimer concentrations and more severe coagulopathies on admission than horses with other diagnoses. Nonsurvivors also had significantly (P < .001) higher plasma D-Dimer concentrations at presentation than did survivors, and those horses with subclinical DIC on presentation had an odds ratio (OR) 8.6 (95% confidence interval [CI], 3.3–22.5, P < .001) for nonsurvival. Finally, D-Dimer concentrations >4,000 ng/mL had a LR+ of 5.9 and an OR 8.8 (95% CI, 4.5–17.1, P < .001) for nonsurvival.
Conclusion and Clinical Importance: Plasma D-Dimer concentration measured on admission can be used to facilitate diagnosis and outcome prediction in horses with colic. A potential cut-off value for nonsurvival was found at approximately 4,000 ng/mL.
- aPTT
activated partial thromboplastin time
antithrombin activity
confidence interval
disseminated intravascular coagulation
positive likelihood ratio
odds ratio
prothrombin time
Historically, gastrointestinal (GI) disorders have been the most prevalent cause of coagulation disorders in horses.1,2 In horses with acute abdominal pain, coagulation problems are common and usually result in a hypercoagulable state. This can progress to the more severe disseminated intravascular coagulation (DIC), resulting in a subsequent consumption coagulopathy.1–4 DIC is rarely clinically evident in horses with colic, although it is possible to diagnose subclinical DIC based on compatible clinicopathologic data.2,5
There is some evidence that the severity of the host inflammatory response to an inciting event may be extremely critical in the development of coagulopathy and may play an important role in patient outcome.6 Ischemic or inflammatory GI problems and other disorders resulting in endotoxemia and severe systemic inflammatory response syndrome more commonly are associated with marked hypercoagulation and may cause DIC.2–4 A high percentage of horses with colitis (up to 36%) and ischemic lesions (up to 70%) have been reported to be in DIC, especially those disorders that have a poor prognosis, such as large colon volvulus.5–7 Additionally, approximately 40% of horses with ischemic and inflammatory GI diseases of poor prognosis were found to have massive fibrin deposition in several organs at necropsy consistent with microthrombosis and DIC.8 Thus, the severity of coagulopathies in horses with GI disorders appears to be related to the diagnosis.
Furthermore, the severity of coagulopathies in horses with GI problems also seems to be associated with poor outcome.3,5,7,9,10 In horses with colitis, the odds of survival in a horse with subclinical DIC were decreased 8-fold relative to horses without subclinical DIC.5 A study of hemostatic profiles in horses with large colon volvulus that underwent surgery concluded that there was an association between development of coagulopathy and outcome, confirming that horses with 4 of 6 abnormal coagulation tests were more likely to be euthanized, and those with 3 of 6 abnormal tests had a prolonged hospital stay.7 Moreover, increases in morbidity and mortality have been associated with alterations in the coagulation and fibrinolysis systems in horses with systemic disease.6,11 Other studies have demonstrated that rapid detection and treatment of subclinical coagulopathies in horses and humans decrease morbidity and mortality associated with development of fulminant DIC.a,10,12,13
To make more valid prognostic assessments in colic cases, many authors have evaluated the usefulness of individual variables taken on admission and during hospitalization, including clinical and clinicopathological data.3,9–11,14–29 Several of these studies included hemostatic parameters and some have been found to be associated with outcome, although results among studies were variable and sometimes contradictory.a,3,9,11,20,21,23,29,30 Common tests to evaluate hemostasis in horses include platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (AT), fibrinogen, fibrin(ogen) degradation products, and D-Dimer concentrations.b,3,5–7,9–11,21,23,29 Newly available tests, such as mean platelet component (MPC) provided by current CBC analyzers, also have shown to be useful to detect platelet activation.31 Other hemostatic parameters typically are not available for evaluation of the clinical patient in a hospital setting.4,32
Plasma D-Dimer concentration is considered the most sensitive test to diagnose thromboembolic disease and DIC in human medicine, and it also has been shown to be a good predictor of mortality.33 In horses, D-Dimers have been found by our group to be a useful tool for detection of hypercoagulable states in horses with colic and septic foals during hospitalization.a,6,34,35 Furthermore, a marked increase in plasma D-Dimer concentration has been found to be associated with ischemic and inflammatory GI disorders, and especially in horses with peritonitis, when determined on presentation.a,c,35 Some studies also have advocated the usefulness of plasma D-Dimer concentration as a good prognostic aid in horses with acute GI problems and recommend its determination for routine screening of colic patients upon admission.c,21,35
The objectives of this study were to evaluate (1) the relationship of admission plasma D-Dimer concentration with the likelihood of survival in horses with several types of colic, and (2) the association between admission plasma D-Dimer concentration and other coagulation profile data with diagnosis and outcome in different acute GI disorders.
Materials and Methods
Horses with colic admitted to the Equine Teaching Hospital of Barcelona between March 2004 and September 2008 were included in this prospective observational clinical study. Foals younger than 21 days, horses with concomitant inflammatory disorders not related to GI disease (eg, pneumonia) or liver disease, horses with 2 or more GI disorders of similar severity (eg, ischemic and inflammatory disorders), and horses with chronic disorders were excluded from the study.
Horses were grouped according to diagnosis in 6 groups, including medical and surgical intestinal obstructions, GI inflammatory conditions, ischemic intestinal problems with or without intestinal resection, and peritonitis. Horses with ischemic lesions were divided into 2 groups because cases with more severe forms of ischemia and those with prolonged ischemia (>6 hours) are associated with more severe coagulopathies that contribute to the death of the horse.36
Diagnosis was based on clinical history, complete physical examination, and results of complementary diagnostic tests (CBC, plasma biochemistry, blood gas analysis, abdominal ultrasonography, and peritoneal fluid analysis). Findings of abdominal radiology, exploratory laparotomy, postmortem examination or some combination of these were used for this classification whenever they were performed. The medical obstructive group included all horses with nonstrangulating, noninflammatory disorders of the GI tract (such as impactions and large colon displacements) without signs of intestinal devitalization, which resolved with medical therapy (IV fluids, enteral fluids, laxatives), whereas the surgical obstructive group comprised those that needed surgery (mainly colon displacements). The enteritis group included horses with acute inflammation of small intestine (duodenojejunitis) or large intestine (colitis, typhlocolitis) or both diagnosed by compatible clinical signs (eg, gastric reflux, diarrhea, fever), clinicopathological data (eg, hypoalbuminemia, acid-base, and electrolyte imbalances) as well as results of complementary examinations (abdominal ultrasound, peritoneal fluid analysis). The ischemic group without intestinal resection included horses with strangulating GI lesions, such as intestinal volvulus or torsion, epiploic entrapment, inguinal hernias, and intussusceptions, where the affected intestinal portion was considered viable and subsequently had good recovery. Animals were included in the ischemic group with intestinal resection when any part of the affected bowel needed to be surgically removed. Finally, the peritonitis group included horses with gastric or intestinal ruptures, as well as septic peritonitis (presence of intra- and extracellular bacteria in peritoneal fluid) caused by bowel devitalization but without rupture, intra-abdominal abscesses and other causes.
Horses also were grouped according to outcome: survivors (horses that were discharged from the hospital), nonsurvivors (horses that died during hospitalization because of progressive worsening of disease or that were euthanized based on poor prognosis), and the financial restraint group (horses that did not receive the suitable treatment for financial or personal reasons). Horses that were either euthanized or left the hospital without medical consent because of economic restraints were not considered in outcome analysis.
Finally, a diagnosis of subclinical DIC was made when horses had clinicopathological evidence of DIC (≥3 abnormal parameters in the coagulation profile) based on criteria used in the equine literature.5,6,37 For the purposes of this study, horses with 1 or 2 abnormal coagulation parameters were considered to have activation of the coagulation system.
Additionally, a group of 30 healthy horses was used as controls, and included horses in regular training from a riding school near the Teaching Hospital, controlled blood donors, and healthy mares (>1 week postpartum) that had accompanied their hospitalized sick foals.
Blood Sampling and Measured Parameters
On admission, blood samples were obtained by jugular venipuncture into 5 mL tubes containing 3.8% sodium citrate by using a vacutainer system.d Immediately after, blood samples were centrifuged at 1,000 ×g for 15 minutes, and plasma was frozen at –80°C until analysis. Plasma D-Dimer concentration, PT, aPTT, and AT were measured in duplicate for all samples, as reported in previous studies.a,c,6,34–36 Clotting times and AT were determined to complement plasma D-Dimer concentrations and to allow classification of coagulation dysfunction. Coagulation tests were considered abnormal when D-Dimer concentration was >1,000 ng/mL, PT > 15 seconds, aPTT > 65 seconds, and AT < 140%, based on previous studies and reference values in our laboratory.a,c,6,35 Other useful hemostatic variables (ie, platelet count, MPC) were not included in this study because after hours sampling prevented insurance of accurate determination in many cases. Also, fibrinogen concentration was not included because of its low sensitivity in assessment of coagulopathies in colic horses.5,6,37 Plasma D-Dimer concentration was determined using an immunoturbidimetere with commercial reagents and controlsf; PT and aPTT were determined with a semiautomatic coagulometerg with commercial reagents and controlsh; and AT was determined with a chromogenic kiti in a semiautomatic analyzer.j
Statistical Analysis
Results were expressed as frequencies and percentages for qualitative variables and median (interquartile range) for quantitative variables. Univariate inferential analysis was performed by Fisher's exact test for categorical data or the Mann-Whitney U test for quantitative variables. D-Dimer concentration was assessed by means of the positive likelihood ratio (LR+) estimation for dying/being euthanized, defined as sensitivity/(1−specificity), to obtain different cut-off values. In general, values of LR+ higher than 5 indicate a moderate increase in the likelihood of the disease, and values higher than 10 indicate a large and often conclusive likelihood. An interval validation of these cut-off values also was performed by means of logistic regression models. Several multivariate models were evaluated by the cut-off values obtained by LR+, adding 1 of the other 3 hemostatic parameters tested (PT, aPTT, or AT) in this statistical study. D-Dimer concentration was included as a fixed factor in all models for different cut-off values (2,000, 3,000, 4,000, 5,000, and 5,500 ng/mL) in order to assess the influence of the 4 hemostatic parameters as covariables. An estimation of the risk of death by number of abnormal coagulation parameters was performed by a univariate logistic regression model. P values ≤ 0.05 were considered statistically significant. With the aim of not inflating type I error rate in subtype diagnostic analysis, comparisons with the control group were only performed by global type (obstructions or ischemias) when nonsignificant relations were observed between subtype of diagnosis (medical versus surgical obstructions, and ischemias with versus without intestinal resection). Statistical analysis was performed by the SPSS 15.0 package.k
Of all horses admitted for colic during the study period, 493 horses met the inclusion criteria and were included in the study. The sex distribution was 174 females (35.5%), 139 intact males (28.4%), and 177 geldings (36.1%). No sex information was available for 3 horses. The median age (interquartile range) of the population was 8 years (5–12 years). No age information was available for 9 horses. One hundred seventy-four horses (35.6%) were Andalusians, 122 horses (24.9%) were crossbred, 28 (5.7%) Arabians, 26 (5.3%) Warmbloods, 24 (4.9%) ponies, 14 (2.9%) and Draft breeds, and the remaining 97 horses were a mixture of different breeds. No breed information was available for 4 horses.
Diagnoses included 229 horses (46.5%) with medical obstructions, 74 (15%) surgical obstructions, 74 (15%) inflammatory problems, 33 (6.7%) ischemic lesions without intestinal resection, 51 (10.3%) ischemic lesions with intestinal resection, and 32 (6.5%) horses with peritonitis.
Of the 493 horses, 387 (78.5%) survived, 80 (16.2%) died or were euthanized because of poor prognosis, 23 (4.7%) were euthanized because of financial constraints, and 3 horses (0.6%) left the hospital against medical advice. The outcome distribution of horses with different diagnoses is shown in Table 1.
|Survivors (n= 387)
|Nonsurvivors (n= 80)
|Financial Restraints (n= 26)
|Medical obstructions
|211 (54.5%)
|2 (2.5%)
|16 (61.5%)
|Surgical obstructions
|67 (17.3%)
|7 (8.8%)
|0 (0.0%)
|Ischemia without intestinal resection
|25 (6.5%)
|4 (5.0%)
|4 (15.4%)
|Ischemia with intestinal resection
|23 (5.9%)
|25 (31.3%)
|3 (11.5%)
|55 (14.2%)
|17 (21.3%)
|2 (7.7 %)
|6 (1.6%)
|25 (31.3%)
|1 (3.9%)
Hemostatic Profile in the Different Diagnostic Groups
Results of coagulation profile data by diagnostic group are presented in Tables 2 and 3. On admission, D-Dimer concentration was markedly and significantly (P < .001) higher in inflammatory diseases (enteritis and peritonitis groups) compared with controls. Despite being also increased in the ischemic group that needed resection, concentrations did not reach significant differences. Clotting times were mildly but significantly prolonged in all colic groups, and AT showed mild differences in both obstructive groups when compared with controls. Comparing horses with medical versus surgical obstructive problems, no significant differences were found between them in any of the hemostatic parameters determined.
|Controls (n= 30)
|Medical Obstructions (n= 229)
|Surgical Obstructions (n= 74)
|Ischemic without Resection (n= 33)
|Ischemic with Resection (n= 51)
|Enteritis (n= 74)
|Peritonitis (n= 32)
|D-Dimer concentration (ng/mL)
|[586; 742]
|[133; 923]
|[168.5; 919.5]
|[135; 1,212]
|[360; 2,687]
|[435; 2,711]
|[1,652.5; 5,923]
|PT (seconds)
|[10.85; 11.4]
|[11.3; 13.8]
|[11.2; 14]
|[11.6; 13.8]
|[11.6; 14.6]
|[12.1; 15.6]
|[13.0; 15.1]
|aPTT (seconds)
|[36.9; 41.2]
|[44.7; 59.7]
|[44.8; 60.1]
|[46.0; 58.0]
|[44.2; 61.6]
|[49.5; 64.1]
|[46.0; 61.5]
|[172; 211]
|[196; 234]
|[198; 244]
|[181; 230]
|[177; 220]
|[166; 214]
|[144; 204]
|Cut-off Values
|Controls (n= 30)
|Medical Obstructions (n= 229)
|Surgical Obstructions (n= 74)
|Ischemic without Resection (n= 33)
|Ischemic with Resection (n= 51)
|Enteritis (n= 74)
|Peritonitis (n= 32)
|D-Dimer concentration (ng/mL)
|29 (96.7%)
|181 (79%)*
|57 (77%)*
|23 (69.7%)*
|25 (49%)*
|38 (51.4%)*
|6 (18.7%)*
|1 (3.3%)
|48 (21%)*
|17 (23%)*
|10 (30.3%)*
|26 (51%)*
|36 (48.6%)*
|26 (81.3%)*
|0 (0%)
|22 (10.3%)
|10 (13.5%)
|3 (9.7%)#
|16 (33.3%)*,#
|26 (36.1%)*
|20 (66.7%)*
|0 (0%)
|10 (4.7%)
|7 (9.5%)
|3 (9.7%)
|10 (20.8%)*
|12 (16.7%)*
|17 (56.7%)*
|0 (0%)
|7 (3.3%)
|6 (8.1%)
|3 (9.7%)
|7 (14.6%)*
|7 (9.7%)
|16 (53.3%)*
|0 (0%)
|2 (0.9%)#
|4 (5.4%)#
|1 (3.2%)
|2 (4.2%)
|3 (4.2%)
|9 (30%)*
|PT (seconds)
|30 (100%)
|198 (86.5%)*
|63 (85.1%)*
|29 (87.9%)
|44 (86.3%)*
|56 (75.7%)*
|24 (75%)*
|0 (0%)
|31 (13.5%)*
|11 (14.9%)*
|4 (12.1%)
|7 (13.7%)*
|18 (24.3%)*
|8 (25%)*
|APTT (seconds)
|30 (100%)
|197 (86%)*
|64 (86.5%)
|29 (87.9%)
|41 (80.4%)*
|59 (79.7%)*
|26 (81.3%)*
|0 (0%)
|32 (14%)*
|10 (13.5%)
|4 (12.1%)
|10 (19.6%)*
|15 (20.3%)*
|6 (18.8%)*
|30 (100%)
|226 (98.7%)
|71 (95.9%)
|33 (100%)
|48 (94.1%)
|66 (89.2%)
|27 (84.4%)
|0 (0%)
|3 (1.3%)
|3 (4.1%)
|0 (0%)
|3 (5.9%)
|8 (10.8%)
|5 (15.6%)
Despite that fact, when specific cut-off values were compared, only 0.9% of medical obstructive cases had plasma D-Dimer concentrations on admission >5,000 ng/mL, compared with 5.4% in the surgical group (P= .04). Comparing horses with ischemic disorders, a tendency toward significance (P < .06) was seen for higher plasma D-Dimer concentration on admission in ischemic cases that needed intestinal resection compared with those in which this procedure was not necessary (Table 3). Furthermore, when specific cut-off values were compared, most (90.3%) ischemic cases without intestinal resection had plasma D-Dimer concentrations on admission ≤2,000 ng/mL, compared with 66.7% in the resection group (P= .017). Differences in other parameters were not significant.
The distribution of horses by number of altered parameters in the coagulation profile by diagnostic group is shown in Table 4. Horses with enteritis, ischemic lesions that needed intestinal resection, and peritonitis had a higher number of coagulopathies, and clinicopathological DIC already was diagnosed on admission in horses with enteritis and peritonitis (10.8 and 9.4%, respectively).
|Number of Abnormal Hemostatic Parameters (out of 4)
|Medical Obstructions (n= 229)
|Surgical Obstructions (n= 74)
|Ischemic without Resection (n= 33)
|Ischemic with Resection (n= 51)
|Enteritis (n= 74)
|Peritonitis (n= 32)
|Normal profile
|Activated coagulation system (1 or 2 abnormal parameters)
|Subclinical DIC (≥3 abnormal parameters)
Hemostatic Profile in the Different Outcome Groups
Results of coagulation profile data by outcome groups are presented in Table 5. Plasma D-Dimer concentration was marked and significantly (P < .001) higher in dead/euthanized horses than in discharged horses. Furthermore, 74.2% of survivors had plasma D-Dimer concentrations within the normal range (≤1,000 ng/mL) compared with 35% of nonsurvivors (odds ratio [OR], 5.33; 95% confidence interval [CI], 3.19–8.9, P < .001). PT also was significantly (P < .001) prolonged in nonsurvivors, and the percentage of horses with PT > 15 seconds also was higher in nonsurvivors (OR, 1.9; 95% CI, 1.1–3.5, P= .03). Antithrombin activity was significantly (P < .001) lower in dead/euthanized horses than in discharged ones, and significantly more animals with poor prognosis had AT < 140% (OR, 14.7; 95% CI, 5.5–39.1, P < .001). Differences were not significant for aPTT.
|Survivors (n= 387)
|Nonsurvivors (n= 80)
|Cut-off Values
|OR (95% CI) P-Value
|D-Dimer concentration (ng/mL)
|383 [143; 1,112]
|2,304 [733; 4,489]*
|PT (seconds)
|[11.3; 13.9]
|[12.0; 15.1]
|APTT (seconds)
|[45.3; 60.7]
|[44.4; 61.0]
|[190; 234]
|[144; 212]
Regarding the type of coagulopathy, there were significantly (P= .009) more horses with clinicopathological DIC (≥3 coagulopathies) upon presentation in nonsurvivors (11.3%) than in survivors (3.6%) (Table 6). Using the univariate logistic regression model, horses with 1 or 2 coagulopathies on presentation were more likely to die (OR, 5.3; 95% CI, 3.0–9.4, P < .001). When horses had clinicopathological evidence of DIC (3 or 4 of 4 abnormal parameters) on presentation, the OR value for mortality increased to 8.6 (95% CI, 3.3–22.5, P < .001).
|Number of Abnormal Hemostatic Parameters on Admission (out of 4)
|Survivors (n= 387)
|Nonsurvivors (n= 80)
|Normal profile
|Coagulation system activated (1 or 2 abnormal parameters)
|5.3 (3.0–9.4)
|Subclinical DIC (≥3 abnormal parameters)
|8.6 (3.3–22.5)
Results of the Positive Likelihood Ratios and Logistic Regression Models
D-Dimer concentrations of approximately 4,000 ng/mL showed a LR+ value of 5.9 for dying/being euthanized. No optimal interval of results to suggest potentially useful cut-off values was identified for the remaining parameters (results not shown). The logistic regression model including plasma D-Dimer concentration (crude analysis) resulted in an OR of 8.78 (95% CI, 4.52–17.05, P < .001) for nonsurvival when values were approximately 4,000 ng/mL. Adjusted OR for D-Dimer concentration (>4,000 ng/mL) by mean PT (>15 seconds), aPTT (>65 seconds), or AT (<140%) did not show substantial changes from crude OR evaluation of D-Dimer analysis. Only AT values <140% maintained a significant effect in the presence of the D-Dimer factor.
The most common coagulopathy in horses with colic is a hypercoagulable state that can progress to DIC. The intensity of this coagulopathy will depend on the severity and duration of the GI lesion, with ischemic and inflammatory problems and peritonitis being most frequently affected by coagulopathies.6,35 Furthermore, the severity of coagulopathies in horses with GI problems also seems to be associated with poor outcome.3,5,7,9 In the present study, plasma D-Dimer concentration was related to diagnosis and prognosis, which could help to differentiate horses with enteritis and peritonitis from other diagnoses, and especially to detect horses with poor outcome. Furthermore, D-Dimer concentration was the most sensitive coagulation parameter for these diagnostic and prognostic purposes of the parameters tested in the present study.
Regarding diagnosis, results of this study indicate that patients with enteritis or peritonitis had significantly higher D-Dimer concentration when tested on presentation, AT was significantly lower and alterations in hemostatic parameters were more severe. These 2 diagnostic groups also included a higher percentage of horses with subclinical DIC on admission. In the literature, inflammatory and ischemic conditions are the diagnoses most often associated with severe coagulopathies, especially when diagnosed during hospitalization.7,8,10,37 In the present study, however, severe coagulopathies were detected upon presentation. In horses with colic and in septic foals, the inflammatory response, and consequently activation of the coagulation system, can be more severe some hours after presentation,a,c,7,34,36 which could explain why abnormalities of the coagulation profile detected on admission usually are milder. In addition, in the present study D-Dimer concentration in ischemic disorders taken as a whole was not significantly higher on admission, although a tendency toward significance (P= .06) was present when comparing horses with or without resection, with D-Dimer concentration higher in horses that needed enterectomy. Previous studies also suggest that D-Dimer concentrations in ischemic colicky horses tend to increase early after admission.a,c Thus, the lack of significance in the group that needed intestinal resection could be associated with the fact that samples were taken too early in the ischemic process.
Regarding diagnosis, when specific concentrations of D-Dimers were analyzed, one third of ischemic horses with intestinal resection had plasma D-Dimer concentrations on admission of >2,000 ng/mL, compared with just 10% of horses in which intestinal resection was not necessary. This additional information can help the clinician determine prognosis and treatment when confronted with such types of colic. In contrast, in obstructive colics there were significantly more horses with plasma D-Dimer concentrations on admission >5,000 ng/mL in the surgical group compared with the medical group. Most horses in both groups (94.6 and 99.1%, respectively), however, had lower concentrations, which limits the applicability of this information in a clinical setting. Clotting times also showed significant differences when compared with controls, but not between medical and surgical obstructions or ischemic problems with or without resection. Finally, AT did not show significant differences for the cut-off values applied.
Enteritis and peritonitis were the diagnoses with the higher prevalence of subclinical DIC upon admission and, together with ischemic lesions (especially those requiring resection), had the highest number of patients with activation of the coagulation system. These findings are in accordance with previous studies.6,7,35 Thus, these severe inflammatory conditions seem to be linked to severe coagulopathies, which are already detected on admission when using sensitive tests. Other diagnoses (such as ischemic disorders) would need to be retested after presentation or by use of a larger coagulation profile to better assess the associated coagulopathy.
In general, diagnoses corresponding to more severe disorders, most commonly associated with nonsurvival, also had the highest percentage of horses with the highest D-Dimer concentrations.
Several studies have attempted to elucidate the role of coagulation abnormalities with fatality during colic.a,c,3,9,11,20,21,23,29 One of the objectives of this study was to evaluate the usefulness of admission results of several hemostatic parameters to predict the likelihood of survival. In this study, plasma D-Dimer concentrations on presentation were significantly higher, PT significantly prolonged and AT significantly lower in nonsurvivors than in survivors. However, while most nonsurvivors had markedly increased D-Dimer concentrations (>1,000 ng/mL), a lower percentage of nonsurvivors had PT and AT results above the reference range (>15 seconds and <140%, respectively). Thus, according to these results, D-Dimer concentration seems to be more associated with prognosis than the remaining coagulation variables tested. Other studies in horses with colic also found higher D-Dimer concentrations in nonsurvivors,21 as well as prolonged PT and decreased AT, thus confirming these results.3,5,7,9,11,29
Horses with plasma D-Dimer concentrations on admission >1,000 ng/mL and >4,000 ng/mL were found to be 5.33 and 8.78 times more likely to die, respectively. This information can be useful to the clinician to predict outcome in a case of colic. Furthermore, horses with AT results below 140% had 14.7 times more probability of nonsurvival. Nevertheless, results of AT are rarely below this level, even in severe colics, and so this information has little clinical value. In contrast, PT did not show a good predictive value for nonsurvival (OR = 1.9). Thus, following our results, D-Dimer concentration could have better prognostic value than the other coagulation parameters tested.
When the coagulopathies were assessed for outcome, there were significantly more horses with subclinical DIC (≥3 altered parameters) in the group of nonsurvivors. Furthermore, horses had 8.6 times more probability to die if they were in subclinical DIC, and 5.3 times more probability if they only had 1 or 2 abnormal coagulation parameters. This finding is not surprising because the literature reports worse outcomes in horses with GI problems associated with a high number of coagulopathies and DIC.3,7,9,10 Postmortem studies also found higher fibrin deposition scores in different organs of horses with colic diagnoses more commonly associated with DIC.8,38 Nevertheless, previous results complementary with this study confirm that alterations of the coagulation profile in horses that survived tend to normalize during hospitalization regardless of the diagnosis.a
Our results have shown that changes in hemostasis are frequent in severe GI disorders of horses. D-Dimer concentration determined on presentation has a clear relationship with outcome. Results of the LR+ in this population of colic horses confirmed that plasma D-Dimer concentration is a sensitive parameter, with concentrations on admission >4,000 ng/mL indicating a moderate to marked increase in the likelihood of dying or being euthanized. This analysis is very similar to ROC curves and area under curve calculations and can be used for equivalent purposes to determine the diagnostic and prognostic utility of a test in different diseases. The LR+ for death used in the present study has the advantage of offering the same optimal cut-off point as does graphical evaluation of the ROC curve, but also considers the goodness of the cut-off point. Furthermore, the logistic regression models combining AT and plasma D-Dimer concentration showed the best LR+ with D-Dimer concentrations to be approximately 4,000 ng/mL. Therefore, based on this study, if a D-Dimer cut-off concentration of 4,000 ng/mL is used on admission, the likelihood ratio of death independently of diagnosis is approximately 6 : 1 (ie, 6 horses with D-Dimer concentration >4,000 ng/mL are likely to die for each horse with D-Dimer concentration >4,000 ng/mL that survives). In contrast, other studies have not found that D-Dimer concentrations provide any additional information in explaining outcome when tested on admission, but they used less accurate methods in a smaller population of horses.7,20
One possible limitation of this study is that the number of hemostatic parameters determined was low, and did not include platelet count or other commonly tested parameters characterized by their low sensitivity. Nevertheless, the parameters determined in this study are those currently used in humans and dogs to evaluate coagulopathies and constitute the basis of DIC scoring systems in these species or are used to increase diagnostic sensitivity.39–41 With such a low number of parameters tested, identification of coagulopathies and diagnosis of DIC could be limited. However, the percentage of coagulopathies and diagnosis of DIC finally detected in the present study was similar to what has been reported in other studies in which more hemostatic parameters were tested.
In conclusion, the present study confirmed that when a simple hemostatic profile that includes D-Dimer concentration was assessed on admission in horses with colic, the most severe coagulopathies were observed in horses with the most severe forms of GI disorders (eg, inflammatory conditions, ischemic intestinal problems that needed intestinal resection, peritonitis) and in nonsurvivors. Furthermore, the diagnoses with higher percentage of nonsurvival also had more horses with high concentrations of D-Dimers. Moreover, this study also supports the usefulness of D-Dimer concentration tested on admission to predict outcome in horses with GI disorders, especially when >4,000 ng/mL. Additional studies are warranted using this cut-off value in a different population of horses to confirm its possible diagnostic and prognostic value.
a Cesarini C, Monreal L, Armengou L, et al. Hemostatic follow up of horses with medical and surgical colic. J Vet Intern Med 2009;23:434 (abstract)
b Byars TD, Thorpe PE. Prognostic significance of fibrin/fibrinogen degradation products in the surgical equine abdominal crisis. Proceedings of the 1st International Equine Colic Research Symposium, Athens, GA; 1982:28-30 (abstract)
c Armengou L, Monreal L, Segura D, et al. Plasma D-dimers in horses with colic. Proceedings of the 8th International Equine Colic Research Symposium, Quebec, Canada, 2005:2–5; (abstract)
d Becton Dickinson Vacutainer Systems, Rutherford, NJ
e Miniquant-1, Biopool, Trinity Biotech, Wicklow, Ireland
f Miniquant, Biopool, Trinity Biotech
g Stago ST4, Stago Diagnostics, Asnières-Sur-Seine, France
h Boehringer Mannheim, Mannheim, Germany
i STA Antithrombin III, Stago Diagnostics
j Cobas-Bio, Roche, Basel, Switzerland
k SPSS, Chicago, IL
- 1Coagulopathy in the equine critical care patient. Vet Clin North Am Equine Pract 2004;20:231–251.
- 2Coagulopathies in horses with colic. Vet Clin North Am Equine Pract 2009;25:247–258.,
- 3Analysis of hemostasis in horses with colic. J Am Vet Med Assoc 1993;203:685–693., , , et al.
- 4Coagulopathy of the critically ill equine patient. J Vet Emerg Crit Care 2009;19:53–65.,
- 5Clinicopathologic evidence of disseminated intravascular coagulation in horses with acute colitis. J Am Vet Med Assoc 2002;220:1034–1038., ,
- 6Coagulation profiles in 27 horses with large colon volvulus. J Vet Emerg Crit Care 2003;13:215–225., ,
- 7Hypercoagulation and hypofibrinolysis in horses with colic and DIC. Equine Vet J 2000;32 (Suppl):19–25., , , et al.
- 8Detection of fibrin deposits in tissues from horses with severe gastrointestinal disorders. J Vet Intern Med 2007;21:308–313., , , et al.
- 9Haemostatic abnormalities in horses with colic—their prognostic value. Equine Vet J 1986;18:271–274.,
- 10Intravascular and peritoneal coagulation and fibrinolysis in horses with acute gastrointestinal tract diseases. J Am Vet Med Assoc 1995;207:465–470., , , et al.
- 11Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Thromb Haemost 1995;74:848–852., , , et al.
- 12Haemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol 1999;60:273–278., , , et al.
- 13Prognostic index for acute abdominal crisis (colic) in horses. Am J Vet Res 1988;49:1969–1971., , , et al.
- 14Development of a colic severity score for predicting the outcome of equine colic. Vet Surg 1995;24:97–101., ,
- 15Prognosis in equine colic: A study of individual variables used in case assessment. Equine Vet J 1983;15:337–344., ,
- 16Study of variables commonly used in examination of equine colic cases to assess prognostic value. Equine Vet J 1986;18:275–277.
- 17A computer-derived protocol using recursive partitioning to aid in estimating prognosis of horses with abdominal pain in referral hospitals. Can J Vet Res 1990;54:373–378., , , et al.
- 18Prognosis in equine colic patients using multivariable analysis. Can J Vet Res 1989;53:87–94., , , et al.
- 19Evaluation of clinical and laboratory variables as prognostic indicators in hospitalised gastrointestinal colic horses. Acta Vet Scand 2004;45:109–118., ,
- 20D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic. Acta Vet Scand 1995;36:255–272., , , et al.
- 21Short-term outcome of equine emergency admissions at a university referral hospital. Equine Vet J 2009;41:459–464., , , et al.
- 22Antithrombin III activity in horses with colic: An analysis of 46 cases. Equine Vet J 1991;23:211–214., , , et al.
- 23Fibrinolytic activity in plasma from horses with gastrointestinal disease: Changes associated with diagnosis, surgery, and outcome. J Vet Intern Med 1995;9:18–23., ,
- 24Prognostic indicators in a Danish hospital-based population of colic horses. Equine Vet J 2000;32 (Suppl):11–18., ,
- 25Large colon impaction in horses: 147 cases (1985–1991). J Am Vet Med Assoc 1995;206:679–685.,
- 26Retrospective analysis of the results of 151 exploratory laparotomies in horses with gastrointestinal disease. Equine Vet J 1993;25:427–431.,
- 27Peritonitis in horses: 67 cases (1985–1990). J Am Vet Med Assoc 1993;203:284–288., , , et al.
- 28Study of the short- and long-term outcomes of 65 horses with peritonitis. Vet Rec 2008;163:293–297., , , et al.
- 29Antithrombin III activity in horses with large colon torsion. Am J Vet Res 1986;47:897–900., , , et al.
- 30Mean platelet component as an indicator of platelet activation in foals and adult horses. J Vet Intern Med 2007;21:1076–1082., , , et al.
- 31D-dimer as a new test for the diagnosis of DIC and thromboembolic disease. J Vet Intern Med 2003;17:757–759.
- 32Plasma D-dimer concentration in sick newborn foals. J Vet Intern Med 2008;22:411–417., , , et al.
- 33Peritoneal D-dimer concentration for assessing peritoneal fibrinolytic activity in horses with colic. J Vet Intern Med 2009;23:882–889., , , et al.
- 34Disseminated intravascular coagulation in experimental intestinal strangulation obstruction in ponies. Am J Vet Res 1983;44:2115–2122., , , et al.
- 35Disseminated intravascular coagulation associated with colic in 23 horses (1984–1989). J Vet Intern Med 1992;6:29–35., , , et al.
- 36Changes in haemostasis in endurance horses: Detection by highly sensitive ELISA tests. Equine Vet J 1995;18 (Suppl):120–123., , , et al.
- 37Detection of fibrin deposits in horse tissues by immunohistochemistry. J Vet Intern Med 2007;21:1083–1089., , , et al.
- 38Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity. Vet J 2009;6 (E-pub)., , , et al.
- 39Prospective validation of the international society of thrombosis and haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med 2004;32:2416–2421., , , et al.
- 40Performance and prognostic importance of a new clinical and laboratory scoring system for identifying non-overt disseminated intravascular coagulation. Blood Coagul Fibrinol 2005;16:69–74.,
- 41The scoring system of the scientific and standardization committee on disseminated intravascular coagulation of the International Society on Thrombosis and Haemostasis: A 5-year overview. J Thromb Haemost 2007;5:604–606.,


text:
Great on trails and not spooky, no vices, and beautiful. Hope has had considerable experience on trails and is promising as a harness or evening horse…SOLD
Meet Briar - a fun and flashy super safe large pony mare. This 14-year-old, 14.2 hand Welsh/Quarter pony beauty is passported with Equine Canada and lots…SOLD
Super Handy 7 year old, 13.2 hand, all around quarter pony that you can trust your little ones on and any adult can have fun! He's a blast to take out…SOLD
This is a very well broke BAY PONY GELDING that is kid broke, beginner safe, and as bombproof as they come. This pony has been used for riding lessons…SOLD
****************** THERE ARE MORE PICTURES ON OUR WEBSITE ****************** Age: 10yro Breed: QH Height: 13.3hh Color: Blood Bay Location: Magnolia…SOLD
Snoopy is a darling palomino gelding with 4 white legs that is gentle for the whole family from ages 4 to 84. He's very typy with great conformation and…SOLD
We have a beautiful Quarter pony that is in her late teens. She walks and trots and neck reins. Very quiet, very sweet, very easy, very gentle. Gives no…SOLD
Ishouldhavebeenacowgirl is an 11 year old Quarter pony, 14.2 and stocky. She is great for trail riding and fun shows. She has experience in cattle cutting…SOLD


text:
Perfect for an hour of walking down to the lake and in top of the dam. Walking the dam from end to end is 0.8 of a mile or just over 1.5 miles back and forth. Terrific views of... read more
One of many parks located on the shores of Canyon Lake.
Your coupon (that we'll email you) gets you 20% off when you spend at least $250 on tours, activities and more that you can book on TripAdvisor or Viator. The more you spend, the more you save!
To learn more about this Book on TripAdvisor Bonus, Viator, and the full list of official rules, click here.


text:
Kathryn Ryan
Host of Nine to Noon
Kathryn Ryan grew up in the South Island is now based in Wellington.
She has a BA degree in History and Education, a post-graduate diploma in journalism, and has also completed university study in business and economics.
A journalist for twenty years, Kathryn began in print, and joined RNZ in 1999.
She spent six years reporting on Parliament in RNZ's Press Gallery office, the last three as RNZ's political editor.
She became host of Nine to Noon in May 2006.
Kathryn has covered the last seven general elections in various roles, including co-hosting RNZ's election night programmes.
Kathryn has travelled widely throughout New Zealand and visited around 20 countries in Europe, Asia and the Pacific, as well as the United States and Antarctica.
Her interests include reading, movies, good food and wine, the great outdoors, tramping and sea swimming.
RNZ Programmes
Nine To Noon
From nine to noon every weekday, Kathryn Ryan talks to the people driving the news - in New Zealand…
More National Presenters
Kim Hill
Station: National
Programme: Saturday Morning
John Campbell
Stations: National, Radio New Zealand
Programme: Checkpoint
Bryan Crump
Station: National
Programme: Nights
Simon Morris
Station: National
Programme: Standing Room Only
Search results for Kathryn Ryan
The week that was with Te Radar and Alice Brine2 days ago
Te Radar and Alice Brine look back at the news highlights of the week. Audio
Sports commentator Brendan Telfer2 days ago
Brendan Telfer joins Kathryn to discuss the latest news from the Rio Olympics. Audio
New music with Jeremy Taylor2 days ago
Jeremy Taylor seeks solace in this deeply troubled world in the soulful sounds of Michael Kiwanuka's sophomore album, the floating, airy guitar stylings of William Tyler, and the defiant majesty of… Audio
Children's book review with John McIntyre2 days ago
Tu Meke Tui by Malcolm Clarke, illustrated by Flox, published by Mary Egan Publishing Are You An Art Sleuth by Brooke DiGiovanni Evans, published by Rockport Pattern Treasure Hunt by Hvass and… Audio
Lynne Kelly: The Memory Code2 days ago
How did ancient cultures record and retain vast amounts of information about animals and plants to pass down to future generations? Australian science writer Lynne Kelly's latest book explores the… Audio
Pacific correspondent Mike Field2 days ago
Mike Field joins Kathryn to discuss the latest news from the Pacific. Audio
Way Wiser2 days ago
Brittany Jordt is CEO of new website Waywiser, connecting people with similar interests, skill levels and schedules to get out in the great outdoors. It's a one stop shop if you want company to go… Audio
Mind over Matter2 days ago
Sue Haldane is the founder of a charity that uses the power of theater to help people get inside the minds of people with autistic spectrum and attention deficit disorders. Her latest workshop is… Audio
Athletics Federation confirms ban on Russia2 days ago
Top Russian track and field athletes are furious after the International Association of Athletics Federations confirmed a ban on their participation in the Rio Olympics due to doping allegations. The… Audio
Summer of Love4 days ago
Sister Corita's Summer of Love is coming to City Gallery. Described as a "Joyous Revolutionary" the Roman Catholic nun captured the civil rights movement, protests against the Vietnam War and condemns… Audio
Science commentator Siouxsie Wiles4 days ago
Siouxsie tells us about a deadly bacteria that can be picked up by a simple sniff, how thumb sucking helps prevent allergies and how smartphone usage correlates with social anxiety and loneliness. Audio
Cooking behind bars4 days ago
Upskilling prisoners through food. Kathryn Ryan speaks to the vegetarian chef from the Wellington on a Plate Rimutaka Prison Gate to Plate event. Audio


text:
Sanjay Leela Bhansali's 'Devdas' starring Shah Rukh Khan in the title role completed 14 years of its release on Tuesday, July 12. On the occasion, Madhuri Dixit, who played the role of Chandramukhi in the film, shared a Dubsmash video of an iconic dialogue from the movie on her Twitter timeline.
Happy Birthday Madhuri Dixit!
Here's wishing a very Happy Birthday to our very own Mrs. Madhuri Dixit Nene! For more Bollywood subscribe to www.youtube.com Facebook: www.facebook.com Twitter: www.twitter.com
Madhuri Dixit Nene
Bollywood diva Madhuri Dixit Nene got emotional and broke down after seeing a performance on the sets of reality dance show 'So You Think You Can Dance - Ab India ki Baari'. The act which brought tears into the eyes of the dancing diva revolved around Parkinson's disease. Contestants Ryan
Actress Madhuri Dixit who was last seen on the big screen in the 2014 crime drama 'Gulab Gang', has signed her next Bollyood film, if reports are to be believed. The 49-year-old actress will reportedly feature in 'Two States' director Abhishek Varman's period drama 'Shiddat', previously titled 'K
Latest Bollywood News
- Neetu Chandra to leave for the US to shoot her debut American series
- Anita Hassanandani sizzles in bikini on her beach vacation with hubby
- 'Dishoom' submitted to CBFC in encrypted format to prevent leak before release
- Teaser: Katrina, Sidharth sizzle in 'Kala Chashma' from 'Baar Baar Dekho'
- Mandana Karimi engaged to boyfriend Gaurav Gupta


text:
Wow. Wow. Wow. So awesome. And realistic.
Following the same design scheme as the Droid 1 and Droid 2, what is purported to be the Droid 3 is better looking than any of the others. A full QWERTY is seen, along with HDMI-out, and what seems to be a 4-inch qHD screen. Mmm, is all we can say. Via: Droid-Life
Formerly Google Mobile App, the new and redesigned version is now named Google Search App. Its obvious use is for searching, complete with a new UI, easier usage, and more speed. The new app is available on the App Store, for free. Via: Google Mobile Blog
The average amount of posts on LaptopMemo has gone down. Why? Because there isn't enough great news to share. But, not at the moment. A fresh new report, is available for your scrutiny below.
Everybody run! Adobe has issued a security exploit warning for Flash on all platforms that it actually works on. The same exploit which can cause crashes and exploits of a user's system is found in both Acrobat and Reader. A fix is coming early next week, so in the meantime, enjoy your imminent doom of crashes or compromising of your system. Via: Adobe
This is about time, you know. After months of Verizon keeping the Thunderbolt in a merry-go-round of possible release dates, the Thunderbolt will launch n the 17th of March for $249.99. 4G LTE speeds are 12MBps down and 5MBps up, and if $20 is added oto your monthly bill, Wireless Hotspot to up to eight different devices. A 32GB microSD card is in included to keep the 4.3-inch WVGA screen company, and unlimited 4G LTE data is priced at $29.99. Get ready for Thursday, because a storm is coming (or so it seems). PR is after the jump.
It's the return of the famous T-Mobile Sidekick, with a 3.5-inch WVGA touchscreen, Android 2.2, a 1GHz A8 Cortex processor, a 3 megapixel camera, Qik video calling, DriveSmart texting-while-driving lockout functionality with Sidekick Group Text and Cloud Text, and is built by Samsung. It also harnesses T-Mobile "4G" HSPA+ speeds of up to 21MBps and will launch "later this spring". Needless to say, these specs won't blow anything out of the park, but if you've been clinging to the Sidekick line, now is the time to get your modern upgrade. Press release after the break.
So, at the HP Summit in San Francisco, HP CEO Leo Apotheker, publicly stated that the HP Touchpad launches in June, and a beta of webOS for PC will debut later this year, but will run in a browser window. Time for more waiting then.
This is the main problem with iPad competition. Manufacturers announce what seem to be promising devices, then launch them at a date after a rival's debuts (read: iPad 2) and any chances of getting the head start is lost. Oh well, more tablets will come out later this year, and only then we shall see who has the edge.
Via: PreCentral
To cut the story short for maximum grasp on the topic at hand and easy reading, AT&T subscribers will get free calling and texting to Japan for the whole month of March, while Sprint and Verizon customers will get the same sort of courtesy until April 10th, both wireless and residential for all aforementioned networks. So, uh, T-Mobile, wanna be a humanitarian this time around? Via: VentureBeat


text:
What happened to my sound card?
Last response: in Components
Related resources
- What does a sound card do and is it necessary? Forum
- My Sound Card Debacle Forum
- Sound card for creative T7900 Forum
- New sound card for under $30 games/music/movies Forum
- Onboard Versus PCI Sound Card Forum
- Motherboard On Board Sound is enough? Forum
- What should i buy? ssd or sound card? Forum
- Pc sound goes in and out Forum
- Help with choosing a new sound card Forum
- Microphone registers, but I'm getting no sound. Forum
- Gaming Sound Card Forum
- What sound card should i get? X-Fi or Barracuda Forum
- Is a sound card worth it? What type? Forum
- What is the point of a sound card? Forum
- Sound lag Forum
- Should I get a sound card? Forum
- Creative Audigy 2 Value 7.1 Sound Card VS. Onboard Sound Forum
- Sound Card for Recording Forum
- Logitech Z5450 with Onboard Sound card Forum
- Sound Card and Speaker selection. Forum
- More resources
Read discussions in other Components categories


text:
sales executive jobs near Portland, OR
Refine your searchClear Filters
Date Added
More Filters
Corporate Account Executive- Portland
Marketo - Portland, OR
4+ years of on-quota transactional sales experience selling B2B applications; On-demand/SaaS, CRM, SFA, and marketing software sales experience is strongly...
Account Executive
Zones, Inc. - Portland, OR
Actively prospect potential customers through outbound calling using Zones' proprietary sales methodology and apply the exceptional sales skills you learned in...
Account Executive, Not Your Typical Investment & Financial Sales Job (2015-2257)
Fisher Investments - Camas, WA
Want to work in a sales environment but not have to cold call? We're looking for people who have what it takes to be great sales people....
Account Executive
MSC Industrial Supply Co. - Portland, OR
2+ years outside sales experience is required. Ensures growth of sales identifies and develops under close guidance new prospects and grows business to...
Head Americas Leader - Medical Business
TE CONNECTIVITY - Wilsonville, OR
Prior sales management experience. Maintain and expand executive customer relationships. Accompany Sales Engineers and Account Managers on customer visits for...
Digital Sales Executive - Portland
YP - Portland, OR
We provide digital sales executives with state-of-the-art training, a great work environment, and a comprehensive benefits package to include:....
SAAS Account Executive
Motus Recruiting and Staffing - Portland, OR
Meeting/Exceeding Sales Quota. At least 1-3 years of successful progressive experience as an inside SAAS sales professional with closing responsibilities Inside...
Sales Account Management
TekCollect - Portland, OR
Account Executive Sales. Sales & Sales Management Opportunity. Our team of sales executives come from varying backgrounds but possess some if not all of the...
Sales / Account Executive
Straub Collaborative - Portland, OR
Sales / Account Executive - Portland. Advertising, marketing, business and sales:. Participate in weekly production meetings with the executive and internal...
Software Sales Account Executive
Legal Anywhere - Portland, OR
Software Sales Account Executive – NW*. We are seeking a capable, ambitious, team oriented and highly-motivated Inside Sales Account Executive....


text:
Written on: 10/12/2012
Found same flights £60 cheaper direct with airline agent after booking, should have checked earlier! Also received no help with complimentary layover package which the Airline told me agents normally book for their customers. Otherwise, the agent I dealt with was courteous and efficient.
Needless to say, my advice is check around first and particularly direct with airline preferred agent before using this agent in future.
As rated by our community of reviewers
" Travel agent and service " Read More
" Easy to book with. emails explained everything perfectly on what ha... " Read More
Written by summer16
" Majestic Europe W/O Disney .A unique experiance 9-22(14days) " Read More
" Peace of mind guaranteed " Read More
Written by London5
" A superb relaxing week in Skiathos " Read More


text:
sais is the plural form of SAI.
1. (computers)
a. uninterrupted power supply, UPS
Search history
Blog Articles
10 Slang Words to Know Before Traveling to Colombia
Top 20 Most Translated English Words
6 Tips to Tackle Ser vs. Estar
View More Articles
El vs. La: A Guide to Your Spanish Nouns
Did this page answer your question?


text:
Crazy Substitute Teachers
Enjoy, NG4.03 / 5.00 1,279 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner3.97 / 5.00 2,359 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.88 / 5.00 3,288 Views
you're very insane
5ed it.
make more
Very bad taste
This movie is of very bad taste for many reasons. Very bad flash in general too.
that thing was violent to my eyes! daily toons sure are wacky, but it was well put together.
well the story made no sense,but the animation is well done and the sound is okay,good work


text:
|Brand Name
|Item Weight
|1 ounces
|Product Dimensions
|11.8 x 8.5 x 2.4 inches
|Item model number
|Material Type
|Number of Items
|8.5 x 11.75 Inch
|Sheet Size
|Manufacturer Part Number
Other Sellers on Amazon
+ Free Shipping
+ Free Shipping
+ Free Shipping
Tops Legal Pad, 8.5 x 11.75 inch, Perforated White, 12 Pads per Pack (7533)
|$10.99 & FREE Shipping on orders over $49. Details
|You Save:
|$1.50 (12%)
- Enter your model number to make sure this fits.
- Everyday weight paper with Letr-Trim perforated sheets for easy removal
- Sturdy back cover is like a mobile desktop, providing additional support wherever you take notes
- 8.5 x 11.75 inch size with legal/wide ruling
- 50 white sheets per pad - Pack of 12 pads
- Made in the USA
|High-Quality Writing and Legal Pads from AmazonBasics
Narrow Ruled 5 x 8-Inch - Canary $6.99
Legal/Wide Ruled 8-1/2 by 11-3/4 - Canary $9.99
Narrow Ruled 5 x 8-Inch - White $6.59
Legal/Wide Ruled 8-1/2 by 11-3/4 - White $9.99
Customers Who Bought This Item Also Bought
Product Description
Compare to Similar Items
This item: Tops Legal Pad, 8.5 x 11.75 inch, Perforated White, 12 Pads per Pack (7533)
TOPS The Legal Pad Legal Pad, 8-1/2 x 11-3/4 Inches, Perforated, Canary, Legal/Wide Rule, 50 Sheets per Pad, 12 Pads per Pack (7532) B0006HWRK8
|Customer Rating
|FREE Shipping
|FREE Shipping
|FREE Shipping
|FREE Shipping
|Sold By
|Save N Save
|2.42 inches x 11.75 inches x 8.5 inches
|2.5 inches x 11.75 inches x 8.5 inches
|2.68 inches x 11.75 inches x 8.5 inches
|1.1 inches x 11.7 inches x 8.4 inches
|Item Package Weight
|5.65 pounds
|5.55 pounds
|6.35 pounds
|2.65 pounds
|Paper Size
|see description
|8 1/2 in x 11 3/4 in
Please help us improve this feature. Tell us what you think of this feature.
Customer Reviews
Top Customer Reviews
The downside is, unless you are ok with having fold creases on your pages (folding it back over the pad), you will need to remove each sheet before moving on to the next one. It takes some practice to rip exactly on the perforation for a clean break, but once you get the feel for it, you'll get it 100%.
Sometimes professors require homework/formula sheets to be exactly 8 1/2" x 11". That's ok for these legal pads, because although it's listed as 8 1/2" x 11 1/2", once you remove the sheet at the perforation line, you will lose that extra 1/2 inch.
A major plus for these legal pads are the cardboard backings, because they can work as standalone tables on your lap. This is contrary to most notepads, which are flimsy and require a hard surface--especially when the paper is running low.
As for price, it's competitive with the market. Buy the 12-pack for extra value.
I recommend these pads for students or business people. Writers and artists may like to look elsewhere, because of the fold creases mentioned above and the difficulty in keeping your work private (no cover).
What I prefer and will get next time is the TOPS Docket letter sized legal pad. Its backing is extra rigid for stand alone use and the paper is heavier. Better yet, is the TOPS Docket Gold letter sized pad with extra rigid backing and 20 lb. weight paper. On second thought, that's the one I will buy next time. I thought I was getting a bargain, but instead what I got was nearly worthless for my use as a professional. These pads will remain around my house for casual use, but I hate the flimsy backing. I cannot emphasize enough how awful the backing is and what a difference it makes in holding and using the pad to write on away from a desk. Also, this thin paper is beyond cheap and unworthy of being written on. It is better suited to squashing a bug with it.
Customer Images
Most Recent Customer Reviews
i offered to bring paper the following week , just clicked on Amazon at the meeting and poof i was the hero the nest week with sharp looking pads….Published 1 day ago by Canthanll Mang
They're so practical and are extremely useful for writing research notes and my endless to-do lists. The pages tear off easily. Read morePublished 4 days ago by Siopnd Marng
This is a nice set of legal pads. Some of the negative reviews state that the backing is very flimsy, but I've found these to work just fine.Published 6 days ago by Hoo L.
These legal pads are great, clean white sheets but I wish the cardboard in the back was more sturdy or stronger. Read morePublished 8 days ago by Jennifer Silverio
As a teacher (high school), I buy 3-4 packages of TOPS Docket Writing Tablet 5"x8", at the beginning of each (school) year. Read morePublished 8 days ago by phoebejo4


text:
human resources jobs near El Cajon, CA
Refine your searchClear Filters
Date Added
More Filters
Director, Global Talent Acquisition
ViaSat - San Diego, CA
This person will have global responsibility for identifying, engaging, and hiring the best talent in the world market place and in so doing will have a huge...
Human Resources Manager
Arch Health Partners - Poway, CA
Conducts and analyzes exit interviews; Supervises Human Resources and Training staff. Ensures legal compliance by monitoring and implementing applicable Human...
Healthcare Recruiter
Preferred Healthcare - San Diego, CA
Medical, dental, vision, and 401(k) matching. Works in collaboration with staffing managers and travel recruiters....
Aya Healthcare - San Diego, CA
Company sponsored happy hours, birthday parties, rewards trips and team building events are always on the horizon....
Sr Human Capital Consultant
TriNet - San Diego, CA
3-5 years Human Resources Management generalist and/or specialist experience required. Co-employing work site employees with more than ten thousand clients,...
Floating/Support Specialist (North/Central San Diego Area)
San Diego County Credit Union - San Diego, CA
Ensure loan files are complete and accurate with appropriate and thorough comments, along with recommendations to aid in loan decision....
HR Site Manager in Fremont, California
SAS Automotive - California
Develop and set-up new recruiting channels and conduct interviews with qualified candidates. A bachelor's degree in business administration, psychology, or...
Assessment and Discharge Specialist
Community Research Foundation - San Diego, CA
Work schedule is 40 hours per week. With more than 30 years of dedication, hard work, and commitment, CRF has earned an enviable reputation among our clients...
General Manager - Assisted Living
Merrill Gardens - San Diego, CA
Responsible for maintaining HR compliance by overseeing the personnel records of all employees, including proper and complete documentation for all new hires,...
Compensation Analyst Human Resources Full-Time
Palomar Health - San Diego, CA
2 - 3 years in related area of Human Resources Preferred Experience:. Valid Driver's License Preferred License:....


text:
Toggle navigation
Place an ad
Sign in with Classifieds account
Sign in with Classifieds account
Place an ad
Search All Classifieds
Business Services
Pets & Animals
Real Estate
Farm & Livestock
Find a job
Post a job
Find a car
Post a car
Find a home
Post a home
Find a rental
Post a rental
Get stuff done
Make money now
Featured Ads
Sun-Mark Properties
2968 Cedar Ln: 3 bdrm 2 bath, 2 car garage Rent $1400
2 Marigold Dr.: 2 bedroom loft golf course condo $1000
For Rent 3 Bedroom, 2 Bath, 2 Car Garage
1765 / Month 3 bedroom, 2 Full Bath, 2 Car Garage,
1200 Sq ft , Includes Gas Fireplace, Gas Stove, Gas Dryer and Washer Dryer, fridge, New dishwasher, New interior paint and lighting, and forced air heating, Laundry room and in home access to garage. Master bedroom has walk in closet and...
10 level acres No Fork Nooksac...
10 level acres No Fork Nooksack. Owner contract. $146K
GENTLY USED high quality TIRES - CANADA - Just across the...
GENTLY USED TIRES - CANADA - Just across the line in Burnaby, British Columbia.
My Prices are in Cdn dollars, and with the current exchange rate, you are able to get amazing tire sets, at incredible prices. $20 and up depending on size and brand.
Just sent me a text with your...
Custom Built Home!
This is the West Seattle custom built home you've been waiting for! From the Saudi Arabian custom tile work, to the grand spiral staircase, every inch of this home was thoughtfully designed. Tranquil views of the sound and Olympic Mountains can be found from most of the rooms in this...
Purebred Yorkies
1 Yorkies female left- . Taking deposits 200 non-refundable. Will have first shots. Been around big dogs since birth. Both parents on site. Mom: AKC Dad: Continental. Super cute and playful. Personalities coming out more and more. They get lots of play time and socializing, loving. Tails will not...
5 private acres w/well & power...
5 private acres w/well & power. 30 min to Bellingham. $39.9K
Beautiful Home in the Heart of Bellingham!
Amazing opportunity to own this 3 bed, 1 bath home in the heart of Bellingham. This home has a large and open living/dinning room with fir floors. Spacious kitchen and adjoining laundry/mud room. The third bedroom has easy access to unfinished potential in the attic. Attached carport and storage...
Recent Ads
emerson ef2 flute
with hard case, good condition,
Standard Poodle puppies
My puppies were raised in my home and are spoiled and ready for adoption. They have had their dewclaws and tails clipped. They were checked by the vet and have health records. They can be registered. 2 males and 1 female available.
Grand Opening
Grand Opening
Scandi Butik & Gifts
Friday~July 29th~ 10:00am-6:00pm
Located in Historical Fairhaven
(Inside Finnegan's Alley)
1106 Harris Ave., Ste 103
Bellingham, WA 98225
Owners: Terri & Hans...
Help center
Give us a call
or visit our
Online Support
Need a job?
Need to hire some help?
Cleaning a House
Fixing a Car
Handyman Work
Personal Trainer
Running Errands
And More...
Find and hire the help you need!
Log in with your
Email Address:
Forgot your password?


text:
is not a beginner pony which is why he is not a fit for my 7 yr old. Needs at least an intermediate rider. Lovable$10,000
little guy. He is patient with his beginner riders, and he can do just about anything...jumping two$250
2012 AQHA Grey Mare. Would make a sweet 4 H Youth mare for an advanced beginner to intermediate$3,500
to hunters and excels in the jumper ring. She has been shown extensively and knows the show ring very well$8,000
*Videos added* fourteen year old Welsh/TB cross mare. Approximately 13.2 hands. Super fancy little mover with former experience in the hunter show circuit…$1,700
with a little more riding experience as she can take advantage of a young beginner. Would make an excellent pony$1,700
Lovely 13.3 hand, seven year old buckskin welsh cross mare for sale. Zoey does everything from eventing to hunters and excels in the jumper ring. She has…$8,000
outright. Confident beginner children have been on her. Stops well not too fast will walk trot canter when$2,500


text:
Visit our other Wisconsin Historical Society websites!
Refine or narrow your results by clicking any term in the gray boxes below.
Expand your results by removing any breadcrumb in a gray outlined box above. Click on the blue "X" to remove the term.
Narrow your results by entering a keyword into the search box above. Then click the "Search Within" checkbox, then click on the orange "Search" button.
If you did not find what you are looking for or you did not get any results, try changing your search term(s). See our Search Help page for more tips.
Date: 1952
Description: Interior perspectives of the Robert Johns residence designed and drawn by architect John Randal McDonald. McDonald gave the project two names, "Spindrift"...
Date: 1996
Description: Artist's rendering of the field level concourse at Miller Park Stadium.
Date: 1862 ca.
Description: This is the preliminary sketch for "Hamburg Landing, 4 miles below Pittsburg Landing, Commisary [sic] Depot of Gen. Hallek's Army." Shows an encampm...
Date: 1948
Description: Drawing of a Madison to Prairie du Chien stage coach in 1848. The coach is driven by two men and drawn by four horses as it passes a farm field separated f...
Date: 1864
Description: Early drawing of the Gates of Heaven Synagogue (on the left) and the Congregational Church (on the right), located on the 200 block of West Washington Aven...
Description: Pencil drawing depicting the first automobile race held in Wisconsin. The two vehicles each carry two men on a rural road. A handful of spectators, includ...
Date: 1881-05-30
Description: Engraving of a sketch by Joseph Pennell showing a parade of League of American Wheelmen bicyclists along Commonwealth Avenue between Dartmouth Street and W...
Date: 1858
Description: Drawing of the exterior of the Shopiere Flouring Mill. Several men, some in a horse-drawn wagon are in front of the building.
Date: 1873
Description: Detail from atlas of the home of Z. Short who settled in 1842.
Date: 1923 ca.
Description: East Water Street at Mason, looking at the Morris E. Fox & Co. building.
Date: 1852-08
Description: Pencil drawing of Milwaukee Harbor with large sailboats on the water. In the minimalist depiction the sandy shoreline with short plant growth sweeps aroun...
Date: 1947-12-13
Description: Design in blue for Wisconsin Centennial 3 cent postage stamp featuring a badger in a subtle "W" design.
Date: 1960-06-08
Description: Blueprint plat of Sunset Hills sub-division.
Date: 1815 ca.
Description: Engraved view of the first state buildings in Columbus, Ohio, including the United States Courthouse, Public Offices and the Old State House. A number of p...
Description: Artist's rendering of the home plate elevation at Miller Park Stadium. Depicts exterior of stadium at night.
Date: date unknown
Description: Elevated view of men working on the assembly line at Rayovac. The title is "Balanced Performance." Written in pencil on parts of the drawing are "Pitch," "...
Date: 1885 ca.
Description: Drawing of the Octagon House with a horse and carriage in the foreground.
Date: 1941
Description: Dimensional drawing or chassis diagram for the International K-8 and KS-8 school bus.
Description: Illustration of a man driving a horse-drawn wagon out of burning woodland.
Date: 1849-07-12 ca.
Description: Wilkins' first sighting of the Rocky Mountains; sketched by Wilkins on his 151-day journey from Missouri to California on the Overland Trail (also known as...
If you didn't find the material you searched for, our Library Reference Staff can help.
Call our reference desk at 608-264-6535 or email us at:
© 1996-2016 Wisconsin Historical Society, 816 State Street, Madison, WI 53706


text:
Camping World Stadium in Orlando will be continue to be the home of the Florida High School Athletic Association football state championships, officials with the FHSAA announced Thursday.
The Leesburg Lightning may have found its postseason stride.
LEESBURG — The Leesburg Lightning took two from the Winter Park Diamond Dawgs on Monday, winning 15-5 in game one and 13-9 in game two at Pat Thomas Stadium-Buddy Lowe Field.
Former Florida quarterback Treon Harris' career with the Gators is over.
A game many adults played as elementary students during recess is going mainstream in Lake County.
It's hot.
LEESBURG — When Drew Peden is on the pitcher's mound for the Leesburg Lightning, victory is a virtual certainty.
Francisco Lindor, the Montverde Academy phenom who has become one of the most important players for the AL Central Division-leading Cleveland Indians, was selected to the American League All-Star team Tuesday.
Lake Minneola High School football coach Walter Banks will hold a free three-day football camp for youngsters, beginning July 18 at Lake Minneola.
TAVARES — Football is not something many people think about when they think of summer, particularly in Florida.
The Orlando Summer Pro League will have a Lake County flavor when it begins Saturday at the Amway Center.
The signs of a team in turmoil often are obvious.
LEESBURG — The Leesburg Lightning scored early and often on Monday en route to a 9-0 win against Winter Garden in a Florida Collegiate Summer League game at Pat Thomas Stadium-Buddy Lowe Field.
MOUNT DORA – When Jesiah Pierre attended the Mark Richt football camp at the University of Miami earlier this week, he was there as just another camper.
Ben Simmons didn't know if he would be the top pick in the NBA Draft.
Montverde Academy is home to one of the nation's top boys basketball programs.
Summer is a time for vacation and relaxing.
DELAND — The Leesburg Lightning were stifled by Matthew Gulik on Wednesday night as they dropped the series finale against the DeLand Suns (7-7), 6-0.
LEESBURG — In front of a packed house at Pat Thomas Stadium-Buddy Lowe Field on Tuesday, Leesburg got back into the win column with an 8-1 victory over DeLand Suns (6-7).
LEESBURG — At least the Leesburg Lightning avoided establishing a new worst start in franchise history.
Location, ST | website.com
© Copyright 2016, South Lake Press, Leesburg, FL. Powered by BLOX Content Management System from TownNews.com. [Terms of Use | Privacy Policy]


text:
OSI-Approved Open Source (187)
- GNU General Public License version 2.0 (124)
- GNU Library or Lesser General Public License version 2.0 (25)
- BSD License (18)
- GNU General Public License version 3.0 (7)
- Mozilla Public License 1.1 (6)
- MIT License (5)
- Apache Software License (3)
- zlib/libpng License (2)
- Academic Free License (1)
- Apache License V2.0 (1)
- Apple Public Source License (1)
- Artistic License (1)
- Common Development and Distribution License (1)
- Common Public License 1.0 (1)
- Mozilla Public License 2.0 (1)
- Other License (7)
- Public Domain (4)
- Mac (197)
- Modern (197)
- Windows (197)
- Linux (185)
- Grouping and Descriptive Categories (171)
- Other Operating Systems (30)
Top Apps
- Audio & Video
- Business & Enterprise
- Communications
- Development
- Home & Education
- Games
- Graphics
- Science & Engineering
- Security & Utilities
- System Administration
WINE for Darwin and Mac OS X
Use Wine (Wine Is Not an Emulator) to run Windows applications on Darwin and Mac OS X.1,624 weekly downloads
4X Space Strategy Game1,362 weekly downloads
Cross-platform CBR/CBZ (comic book) reader988 weekly downloads
A cross platform multi-network peer-to-peer (P2P) file-sharing client.41 weekly downloads
PlayerPro music editor and SoundTracker
Play SoundTracker media on your computer.61 weekly downloads
Drcom-Client is an open source ISP client for logging in to the 2133 Broadband Remote Access Server (also known as Dr.COM). It is released under the GNU General Public License. It is available for GNU/Linux and Windows now.17 weekly downloads
Hotline Connect
Hotline Connect is a cross-platform, multi-purpose client/server communication software suite.19 weekly downloads
The Medlane project is an attempt to create a set of tools that will enable librarians to move from the standard MARC (MAchine Readable Cataloging) format to a new library/museum XML format. This move will ensure traditional library/museum data remains15 weekly downloads
WebDAV C++ Client
WebDAV C++ library.14 weekly downloads
Universal Media Manager
Cross platform media manager using XBMC scrapers, featuring a upnp server, fanart, poster and thumbnail support as well as meta data information about movies, tv shows, music, games and more.6 weekly downloads
Control BioAcceso
BioAcceso es un sistema para el control de asistencias de los empleados, tomando la huella dactilar del personal para su registro e identificación. Es una aplicacion de escritorio desarrollada con el lenguaje Java, utlizando Mysql Server como RDBMS.12 weekly downloads
LPT Interface
The 'LPT Interface' application is great for students. With 'LPT Interface' pupils can write & read the parallel port's: Data Port (8 bit), Control Port (4 bit) and read Status Port (4 bits).11 weekly downloads
Residential Property Manager
Several applications for use by the management of residential hotels and apartment buildings. At the moment, only the Do Not Rent List app is in existence, and almost complete. Future applications include a rent management program and others (suggestions5 weekly downloads
Crown and Cutlass
Crown and Cutlass is a 3d pirate action/adventure game in the spirit of the old Pirates! game. It is written in C++, using OpenGL and SDL with an emphasis on cross-platform compatibility.3 weekly downloads
DSA - Half-Life
Rastullahs Lockenpracht ist ein neuer Versuch des DSA-HL Teams ein Spiel zum Rollenspiel 'Das Schwarze Auge' zu kreieren. Dabei entwickeln wir eine 3d FPS-Spielengine auf der Basis von OGRE.5 weekly downloads
Qlogico is a digital circuit simulator. True table, manipulation of boolean expresions, schematic capture and simulation, finite state machines, table of transitions, VHDL.4 weekly downloads
AA3D- Ascii-Art 3D engine
AA3D - Ascii-Art 3D engine all-software cross-platform 3D library in C that uses a terminal as its display system.3 weekly downloads
DOEDELS is a (multi- and) singleplayer adventure enigine written in java(j2se1.5 +). The project contains the games-engine and some editors to create your own 2d adventures. The Adventure will allow to mix the gameplay with some details of RPG- and strat3 weekly downloads
Dragon Magi
A new game for Mac OS X as well as Mac OS 8-9 and Windows. Think SuperMario and Dungeons and Dragons. This 2-D side-scrolling RPG is sure to captivate you as you play through its many levels with plot twists at every corner.3 weekly downloads
Java IM Bot
JIB - Java IM Bot, aimed to built a pluggable, customizable, expandable and dynamic bot framework for instant messager. With JIB user can control remote IM Bots over web based interface, configure bots to perform various tasks or custom behavior.3 weekly downloads
Pangaea will be a robust and feature filled game engine built using Allegro (http://alleg.sourceforge.net) It will be similar to Final Fantasy 1-3, etc., complete with map editor/world builder.3 weekly downloads
XM Administrator
XM Administrator is a GUI administration tool for the XMail Email Server developed by Davide Libenzi (www.xmailserver.org). It is written in C++ using the QT3.4 framework so it is compilable to run on Linux, Macintosh, and WIN32 platforms.3 weekly downloads
A cross-platform transcription application.3 weekly downloads
Balour is a 3D multiplayer game for Linux, Windows and Mac OS X. Aim of the game is to shoot each other with small vehicles. The complete source was/is written in C++.2 weekly downloads
Explore a strange new world in this exciting Anime-style RTS. With sentient beings that grow on plants, gaseous creatures, underground mining, and domestication of creatures, this new RTS will allow exciting Gameplay Options such as Flag King.2 weekly downloads


text:
Trending Now
50% Off HP ProLiant ML10 v2 Tower Server System
Up to $400 Off Top Cardio Equipment + Free Shipping
SAVE $150 on Apple - MacBook Air 13.3" + Free Shipping
Up To 25% Off Select Back-to-College Must Haves
Up to 60% off RRP on Nike at USC
10% Off + Free Shipping for Premium Leather Sleeves
Up to 70% off Shark Products On Amazon
Over 50% Off + Free Shipping on IKEA Furniture - On Amazon.
Over 25% Off + Free Shipping on IKEA Furniture - On Amazon.
Great Deals on Tech - Up to 70% Off
Shop Now
Looking for your product...
Sorry, we couldn't identify the product.Try again?
Save this coupon
Save this deal
Get Deal
Save this deal
Get Deal
Save this coupon
Save this coupon
30% offAlawar Entertainment: Order any game at www.alawar.com, use the coupon code at the last step of the purchase and save 30% of the regular price for your Christmas entertainment and presents! Offer is valid until December, 31st, 2008


text:
Star Tracks
Timberlake hits the green at his charity golf tournament in Las Vegas. Plus: Pink & Willow, Kate Middleton, Sofia Vergara and more
Credit: Santiago Baez/Ramey
Updated: Thursday Sep 29, 2011 | 05:00 PM EDT
More from PEOPLE
Latest News!
- WATCH: We Go Bowling with Daya!
- Read the Cover Story: JFK Jr.: The John We Loved
- Inside Ivanka Trump's Chaotic Life Raising Three Children: 'I'm Exhausted 90 Percent of the Time'
- WATCH AND SHOP: The Bracelet Inspired by Styles Stars Love – for Less
- Superman Is that You? Henry Cavill Pranks Will Smith with Very Convincing Comic-Con Disguise