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The Commonwealth Center for Advanced Manufacturing (CCAM) received its full certificate of occupancy and opened its facility in Prince George County, Va., this September. CCAM has been steadily growing both in members and machinery and is expected to host a grand opening event in spring 2013.
CCAM has added three Tier 2 and three Tier 3 industry members over the last few months, bringing the total number of participating companies to 14.
The applied research center includes a high bay area, five machining labs, five computational labs, a visualization lab, meeting rooms with conferencing ability, open and modular workstations, and a cafeteria.
With participation from its industry partners and university members, engineers at the center are currently working on 10 research projects. One project involves adaptive machining, which uses specialized equipment to measure and make adjustments in real time as components are being manufactured, leading to improved performance and lower costs.
Another project incorporates multi-modal part inspection, which uses imagery to obtain information and identify small defects early in the manufacturing process, allowing any issues to be fixed before entering into high-rate production.
CCAM is another example of the public-private partnership between Virginia's leading universities and world-class manufacturing companies to bring real-world solutions to the market more quickly. To learn more about CCAM, visit www.ccam-va.com.
CCAM's high bay area includes a Laser Powder Deposition Machine and the Sulzer Metco Thermal Spray Cell, pictured below.
Since going on the road in spring 2010, the STEM Mobile Learning Lab has hosted 15,000 visitors in more than 300 locations. The lab offers numerous hands-on experiments as a method of educating K-12 students and members of the community in STEM subjects—science, technology, education and math.
The STEM Mobile Learning Lab was established by the Institute for Advanced Learning and Research (IALR), a research, education and conference institute based in Danville, Va.
The 38-foot trailer contains multiple work stations, a clean area for experiments and a movie screen. Its impressive equipment list includes several laptops, high resolution microscopes, an HDTV video monitor, and additional demonstration gear.
The STEM Mobile Learning Lab offers experiments in the areas of nanotechnology and renewable energy. Leading by example, the flex-fuel truck that tows the lab can run on either diesel fuel or cooking oil.
Using the STEM Mobile Learning Lab, students can participate in experiments that compare the energy efficiency of CFL and incandescent light bulbs, see how wind and solar power work, learn about energy conservation and how to weatherize doors and windows, and even look at microscopic particles on their own skin.
Preparing students to join the Commonwealth's world-class workforce in the growing fields of science, technology, engineering and math is key to keeping Virginia at the top. According to Cyberstates 2011, Virginia has the nation's highest concentration of high-tech workers.
To learn more about Virginia's premier education system and quality workforce, click here.
Students use high resolution microscopes to participate in one of the many hands-on experiments offered by the STEM Mobile Learning Lab.
VEDP's International Trade division recently released an exporting guide focused on the unique needs of service companies called "Exporting Services: A Guide for New Exporters."
Some of the issues addressed in the guide include assessing export readiness, understanding export regulations, identifying a target market, protecting intellectual property, acquiring work permits and certifications, developing a market entry strategy, and negotiating financing and payment terms.
The services industry is thriving in Virginia—professional, scientific and technical services was the top sector for job creation in 2011, announcing 12,769 new jobs. With human capital as the major input, it's no surprise that Virginia's highly skilled workforce has proved to be a key advantage in growing this sector.
According to The Brookings Institution, Virginia's service exports accounted for 42.6 percent of the state's total exports in 2010, illustrating an opportunity to grow Virginia's exports in a sector where the Commonwealth has the resources to leverage its success into international markets.
Helping Virginia companies grow sales overseas not only benefits Virginia businesses, but it also creates jobs at home. According to The Brookings Institution, Virginia exports supported more than 236,000 jobs in 2010.
To learn how VEDP's International Trade division can help your company grow, go to www.exportvirginia.org.
Fortune 500 company Celanese Corp. just announced it will invest $150 million to convert its Celco Plant in Giles County, Va., from coal-fired to natural-gas fired boilers. The project will create 22 new full-time jobs, as well as employ an estimated 200 construction workers.
Celanese Corp. is a global technology leader engaged in the production of specialty materials and chemical products used in a wide variety of industries and applications. The Virginia Celco Plant has helped make the company a leading producer of cellulose acetate tow, used in filter media.
The Celco Plant first established operations in Giles County, Va., in 1939 and is the largest employer in the county. Positioned along the New River and Route 460, this location offers the unique combination of a picturesque setting between the mountains, easy access to I-81, and close proximity to Virginia Tech and the region's skilled and educated workforce.
This investment will allow the company to reduce its greenhouse gas emissions while updating equipment to improve its energy efficiency—two goals aligned with the company's core values of sustainability and operational excellence.
This project continues the positive trend of Virginia manufacturers making significant investments to upgrade to more environmentally-friendly sources of energy. Last year, MeadWestvaco announced plans to invest $285 million to construct a new, state-of-the-art biomass boiler at its Covington plant, and just last week RockTenn hosted a ribbon-cutting ceremony to celebrate the completion of a natural gas pipeline to its West Point mill.
To learn why leading manufacturers continue to invest in the Commonwealth, bringing more than $13.8 billion in projects over the last decade, click here.
A view of the Celco Plant from across the New River.
Today, VEDP launched the YesVA app for iPad, iPhone and Android devices available for download by visiting www.YesVirginia.org/app or through the App Store and Google Play Store.
The YesVA app is an interactive tool that allows clients and site selection consultants to perform site and building searches and compare Virginia to other states, directly from a mobile device.
The YesVA app allows users to perform the following actions: • Explore Virginia's existing inventory of available properties in an easy-to-use map • Navigate properties by type and narrow down options based on user requirements • Save properties for later and share them with contacts • View 1:1 attributes of how Virginia compares to other states in major business categories • View profiles for each of the communities, regions and MSAs in Virginia • View recent industry announcements for each community • Communicate with VEDP regarding any of the properties within the appBy helping companies make the most informed decision on business locations, the YesVA app is yet another example of an innovative tool developed by VEDP to market Virginia as a top state for business.To download the free YesVa app, visit www.YesVirginia.org/app or go directly to the App Store and Google Play Store.A view from the main screen of the YesVa app.
This week, the National Tire Research Center (NTRC) hosted a ribbon-cutting ceremony to celebrate the unveiling of its new tire testing machine called the "Flat Trac LTRe."
This high-performance, $11.3 million machine is the only one of its kind. It allows speeds up to 200 mph on car, truck and motorsports vehicles and tests tire performance during acceleration, brake and burnout events, as well as wheel torque capability.
Located in the Virginia Motorsports Technology Park adjacent to the Virginia International Raceway track in Halifax County, the NTRC provides easy access to real-world testing right on a premier race track.
NTRC is an applied research and testing facility established in 2010 through a public-private partnership between the Virginia Tech Transportation Institute, General Motors, the Institute for Advanced Learning and Research, and the Virginia Tobacco Indemnification and Community Revitalization Commission.
By combining the industry leadership of General Motors with the research prowess of Virginia Tech, NTRC will focus on developing safer tires that are environmentally friendly, providing higher fuel economy with lower emissions.
Southern Virginia has become quite a hub for the automotive industry. NTRC has partnered with nearby Southern Virginia Vehicle Motion Lab (SoVa Motion), a facility also operated by Virginia Tech that rounds out the region's offering to automotive manufacturers by providing shock and suspension testing, on-vehicle sensing, and full-motion driving simulation.
Virginia's advanced manufacturing capabilities cover all aspects of the automotive industry. To learn why automotive companies have invested more than $1 billion in the Commonwealth over the last decade, click here.
Dr. Tom Dingus, director of the Virginia Tech Transportation Institute, addresses the crowd at the National Tire Research Center ribbon-cutting event in Halifax County.
The Center for Coatings Application, Research, and Education (C-CARE) was unveiled this Monday at a ribbon-cutting ceremony in South Boston, Va.
C-CARE's mission is to help commercialize solutions in the field of surface engineering and attract advanced manufacturing companies to the region by providing workforce training, R&D, and improved links between educational institutions and industry partners.
The 12,000-square-foot, climate-controlled facility includes a lab equipped with advanced robotics, reciprocating spray equipment, and virtual reality training systems. C-CARE's lab will be used to test new coatings technologies and design solutions that increase product quality and efficiency for applications in the aerospace, automotive, construction, food, manufacturing and wood industries.
This two-year project is the result of collaboration between Halifax Industrial Development Authority, the Riverstone Energy Center, and the Southern Virginia Higher Education Center.
The American Wood Finishing Institute (AWFI) will operate and staff the facility. As a leading provider of coatings technology training and consulting, AWFI will offer C-CARE access to subject matter experts with real-world experience applying coatings to metal, wood, plastics and other composite materials.
C-Care augments Virginia's existing strength in the advanced manufacturing sector, as leaders such as the Altria Group, DuPont, Honeywell, MeadWestvaco and Rubbermaid have all established operations in the Commonwealth.
To learn why Virginia is home to more than 6,000 manufacturing establishments, click here.
Virginia Deputy Secretary of Commerce and Trade for Rural Development Mary Rae Carter (center) joins members of C-CARE, industry partners, and state and local officials at the ribbon-cutting ceremony in South Boston, Va.
University-Based Economic Development (UBED) has been a top priority for Virginia, and yesterday VEDP executed a Memorandum of Understanding (MOU) with Virginia's public institutions of higher education and the State Council of Higher Education for Virginia (SCHEV).
Through increased partnership in marketing and outreach, the goals of the MOU are to unify Virginia's message in the global marketplace and provide a higher number of corporate contacts for VEDP and increased opportunities for Virginia's institutions of higher education to interact with corporate entities.
The MOU creates a formal framework around an already existing relationship between VEDP and Virginia's colleges and universities. Virginia's UBED team has been in existence for seven years and has fostered collaboration on numerous workforce development and research projects.
According to VEDP President and CEO Martin Briley, "This MOU provides a meaningful blueprint to more fully leverage higher education as a differentiator in our economic development outreach marketing, and it reinforces the message to our corporate partners that our public colleges and universities are dedicated to leveraging research and workforce assets to benefit the business community."
Access to a solid pipeline of skilled and educated employees can be a deciding factor when companies seek to relocate or expand operations. Virginia has one of the most well-educated workforces in the country—more than 34 percent have at least a bachelor's degree and more than 500,000 students are enrolled annually at Virginia's top-ranked higher education institutions.
To learn more about the Commonwealth's premier education system and why its workforce is consistently commended by companies, click here.
(From left to right) Secretary of Commerce and Trade Jim Cheng; Peter Blake, Executive Director of SCHEV; Dr. Michael Rao, President of Virginia Commonwealth University; Secretary of Education Laura Fornash; and Martin Briley, President and CEO of VEDP; participate in the MOU signing ceremony.
Last Thursday, RTI International Metals Inc. (RTI) hosted an event celebrating its inaugural production of certified commercial aerospace titanium for Airbus.
The $135 million forging, grinding and hot rolling manufacturing facility was first announced in 2008. The plant is located at the Patriot Centre, an industrial park jointly developed by Henry County and the City of Martinsville.
While 25 jobs have been created to date, that number is expected to increase as the plant ramps up production. At full capacity the facility can produce 14 million pounds of product annually.
The inaugural production follows 10 months of certification testing to meet the high quality standards of Airbus. The titanium will be used in Airbus' passenger jets, including the company's A350 XWB aircraft. As RTI completes additional qualifications, it expects its titanium to be used in an extended number of Airbus programs.
According to RTI Vice Chairman, CEO and President Dawn Hickton, "RTI is the largest North American titanium supplier to Airbus and its parent company, EADS, and this new facility adds an additional link in RTI's ability to meet their needs across the entire supply chain."
This project exemplifies the strength of Virginia's advanced manufacturing capabilities across the Commonwealth. The aerospace industry is taking note as well: Business Facilities magazine ranked Virginia No. 7 as an Aerospace/Defense Industry Leader in its 2012 State Rankings Report.
More than 230 aerospace companies are located in Virginia and the Commonwealth has received more than $1.5 billion in capital investment for aerospace projects over the last ten years. To learn more, click here.
Governor McDonnell addresses company and local officials at the RTI International Metals event in Martinsville, Va.
Last week, RockTenn hosted a ribbon-cutting ceremony celebrating the completion of a pipeline supplying natural gas to its mill in West Point, Va.
RockTenn and Virginia Natural Gas collaborated with Dominion Virginia Power, New Kent County, King William County and the Town of West Point to ensure the project was a success.
The 11-mile pipeline will run along Dominion Virginia Power's right-of-way and connect Virginia Natural Gas' line in New Kent County to the West Point Mill.
RockTenn is also investing in its West Point Mill to make the facility more efficient and reduce emissions, lessening the mill's carbon footprint.
The West Point Mill produces containerboard used in the company's consumer packaging products. In operation since 1914, the mill is the region's largest employer with a workforce of 550. RockTenn operates facilities across the Commonwealth, including a mill in Hopewell and a converting plant in Henrico County, Va.
The natural gas pipeline represents a significant improvement in infrastructure, positioning the region for additional growth.
Virginia is home to more than 6,000 manufacturing establishments. To find out why manufacturers have invested more than $13.8 billion in the Commonwealth over the last decade, click here.
Carrie Roth (center), Deputy Secretary of Commerce and Trade, is joined by company, local and regional officials at the RockTenn West Point Mill ribbon-cutting ceremony.
Virginia Beach recently hosted the 2012 AWEA Offshore Wind Conference, welcoming offshore wind energy leaders from across the globe.
Coming shortly after Governor McDonnell's Conference on Energy in Richmond, Va., the Commonwealth continues to lay claim to the title "Energy Capital of the East Coast."
Lieutenant Governor Bill Bolling spoke at the opening ceremony and VEDP Managing Director Jerry Giles was one of the panelists for the Virginia Spotlight session. Representatives from the Port of Virginia, the Virginia Department of Mines, Minerals, and Energy, and the Virginia Department of Commerce and Trade spoke at events throughout the conference.
In addition, VEDP shared a trade show booth with Poseidon Atlantic in close proximity to Fugro and the Virginia Offshore Wind Coalition. Other Virginia-based companies in attendance included Apex Wind Energy, Bechtel Corp., and Maersk Line Limited.
VEDP and its partners continue to promote Virginia as the natural choice for the offshore wind industry. With its strong Class 6 winds, Virginia offers companies a central mid-Atlantic location, a high voltage transmission grid close to shore, and a premier maritime workforce with the largest industrial military complex in the U.S.
While the industry awaits news on the U.S. Bureau of Energy Management's (BOEM's) competitive auction process from its call for nominations last February, Virginia companies continue to make progress both on and offshore.
Poseidon Atlantic has installed its Light Detection and Ranging (LIDAR) monitoring position in Northampton County, Va., as part of its wind measurement campaign. The results show wind conditions are better than expected. The company has also commenced its phase two study investigating offshore testing sites.
Wind energy remains an important component of Virginia's all-of-the-above approach to the energy crisis. Home to more than 380 energy companies, the Commonwealth has seen more than $4.6 billion invested in energy projects over the last ten years. To learn more, click here.
Deputy Secretary of Commerce and Trade Carrie Roth speaks about Virginia's wind resources to a group of wind energy leaders at a dinner hosted by VEDP.
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The Virginia Economic Development Partnership (VEDP), a state authority created by the Virginia General Assembly to better serve those seeking a prime business location and increased trade opportunities, provides confidential site selection and international trade services. VEDP's mission: To enhance the quality of life and raise the standard of living for all Virginians, in collaboration with Virginia communities, through aggressive business recruitment, expansion assistance, and trade development, thereby expanding the tax base and creating higher-income employment opportunities.
To learn why companies continue to find success in the Commonwealth and why Virginia is ranked America's Top State for Business, click here.
Virginia Tech has developed a number of University-Based Economic Development (UBED) programs as part of its long-term strategy to help connect faculty and students with companies and communities.
According to John Provo, Office of Economic Development Director, "The global network starts as soon as you walk out the door. We facilitate the sharing of Virginia Tech's intellectual capital with the private sector to develop problem-solving solutions."
One such group is VT-IDEA (Virginia Tech Intelligence and Defense Executive Alumni). Founded in January 2009, VT-IDEA is made up of alumni working in senior government and industry positions in the national security sector. The group's mission is two-fold: it serves as both a resource for national security professionals to better connect, and it helps Virginia Tech get even more plugged in to the national security space.
Through its efforts to build a faster pipeline from the research in Blacksburg to the cyber security needs in D.C., VT-IDEA has recently helped introduce two new ideas to industry insiders. The first is a data safeguarding device that can wipe tablets and cell phones clean, removing confidential information once the individual has left a secured area. The second technology foils radio signal eaves-droppers. The technology senses the intrusion and reconfigures the network to make it secure.
VT-IDEA not only helps spot and commercialize winning solutions; it also puts early stage entrepreneurs in touch with financing and venture capital sources. The group will be doing just that at its upcoming meeting "VT-IDEA Presents Innovation and Entrepreneurship at VTECH" on June 21 at the VT Research Center - Arlington.
To learn more about how the VT-IDEA group and Virginia Tech's Office of Economic Development are building partnerships with the business community, click on the highlighted links.
German manufacturer McAirlaid's recently celebrated the addition of a 75,000-square-foot expansion to its existing U.S. headquarters in Rocky Mount, Va. Adding to the company's 70,000-square-foot facility at Franklin County Commerce Center, the expansion will increase the company's global capacity by 30 percent while creating 40 new jobs in the region.
The expansion provides McAirlaid's with the additional space to serve its customers in the hygiene, medical, food packaging, filtration and home décor spaces through its non-woven absorbency materials. It also allows the company to reduce imports of raw materials and rely more heavily on U.S. vendors, primarily on the East Coast.
McAirlaid's first announced it would establish its U.S. headquarters in Virginia through an $85 million investment in 2006. In the words of CEO Alexander Maksimow, "Franklin County's commitment to education through the public school system and job training programs, coupled with an existing workforce of highly motivated people with a strong work ethic, were key factors in McAirlaid's site selection."
Since opening its U.S. headquarters in Franklin County in March 2008, the company has received a warm welcome while experiencing the benefits of Virginia's skilled workforce, education system and premier East Coast location. This additional investment allows McAirlaid's to build on its success to date, illustrating the company's commitment to grow in Franklin County.
To learn why companies continue to locate in Virginia due to the Commonwealth's skilled workforce and excellent education system, click here.
Company and local officials joined Mary Rae Carter, Deputy Secretary of Commerce and Trade for Rural Economic Development, at McAirlaid's ribbon-cutting ceremony.
Universities play an essential role in developing the human capital so important to economic development, leading to the current term UBED (University-Based Economic Development). Over the coming weeks, VEDP will feature a series of blogs focusing on what universities are doing across the Commonwealth to play a more active role in reaching out to the business community.
According to Tom Osha, President and CEO of Old Dominion University's (ODU) Innovation Research Park (IRP), ODU is transitioning to a more active role in economic development by developing a 24/7 live-work-play community. IRP is capitalizing on the move away from traditional research parks to an updated model — the "knowledge community."
This new community caters to the next generation of researchers who desire a higher level of engagement in the neighborhood where they work. No longer satisfied with commuting home to the suburbs, this generation is looking to live, work and play all in the same location.
IRP provides just that through its location within ODU's University Village. Impressive on its own, IRP currently has 350 employees working in two 100,000-square-foot buildings, with plenty of room for expansion. Add to that University Village's 10 restaurants, retail stores, hotel, theater, art gallery and the Ted Constant arena, and one can see the attractiveness of such a hub.
The economic development impact occurs when companies are drawn to communities like this, bringing with them investment and new jobs to the area. One such company is ipConfigure, which chose to locate at IRP over a location in Texas due to ODU's multidimensional offerings.
ODU's Computational Intelligence and Machine Vision Lab was a significant consideration for the company, as their video surveillance technology utilizes just the sort of facial recognition algorithms developed at the lab. Easy access to a qualified employee base and close proximity to amenities also clinched the deal.
"ipConfigure hires ODU graduates and interns, utilizes the ODU Business Gateway, eats in the ODU Village, puts guests up at the hotel, buys tickets to ODU football and other sporting events, and attracts its customers to come to IRP to see the research happening at the Vision Lab and elsewhere around ODU," Osha stated.
The university also put ipConfigure in touch with the Virginia Port Authority, the first customer of the company's new Wide Area Surveillance products.
ODU is a shining example of a Virginia university that is seeking to bring the benefits of its research outside the classroom by catering to the needs of businesses. To learn more about ODU's interaction with the business community, click here.
The Blacksburg-Christiansburg-Radford area was ranked Top 5 on the recently published Forbes.com Best Small Cities for Jobs list. Looking at 242 MSAs, Forbes.com calculated the ranking using employment numbers from the Bureau of Labor Statistics for the period November 2000 through January 2012.
This ranking continues the positive recognition the region has received including a No. 4 rating on Site Selection magazine's Governors Cup for metro areas with a population of less than 200,000. Blacksburg, Va. was also named the No. 1 Best Place in the U.S. to Raise Kids by Bloomberg Businessweek.
The Blacksburg-Christiansburg-Radford MSA continues to receive accolades for a number of reasons. Home to top-ranked Virginia Tech, the area's workforce is highly educated, with two-thirds of residents above the age of 25 holding a bachelor's degree or higher and 40 percent holding a graduate or professional degree.
The research capabilities of Virginia Tech combined with a highly-educated workforce have proven to be a winning combination, attracting companies and research parks to the area. The Virginia Tech Corporate Research Center, located adjacent to Virginia Tech's main campus, is home to 140 high-tech companies which employ more than 2,200 Virginians.
The Blacksburg-Christiansburg-Radford MSA is able to retain its highly-skilled workforce due to the strong quality of life the region offers. The family-friendly community provides residents with numerous recreational activities due to its convenient access to the Appalachian Trail, Washington-Jefferson National Forest, Smith Mountain Lake and New River.
To learn more about the Commonwealth's plentiful resources — including a world-class workforce, top-ranked education system and strong quality of life — that make Virginia America's Top State for Business, click here.
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Just a bunch of Beady goodness...
This is where we are supposed to talk about ourselves, but we are actually quite boring...so why don't we talk about some of the great items we are offering in our store that you see in the pretty slide show above...ooooh...ahhhh.
Featured Wood of the week: Nangka
Nangka Wood comes from the Jackfruit tree, a type of mulberry tree, native to Southeast Asia. Its fruit is the largest tree borne fruit in the world. The wood of the tree is most commonly used in the production of musical instruments because it is soft and very lightweight.
Featured Findings of the week: Ball Head Pins
We've just restocked our Ball Head Pins in four different finishes: Antique Brass, Antique Copper, Gunmetal, and Silver. Hopefully by the end of the year we will order some Gold and Rhodium.
Featured Glass/Resin of the week: Resin Rose Cabs
We've just re-stocked many of our 10mm Resin Roses (more colors on the way!). These are one of our most popular items and a great our gluing on Earring Posts or Rings Blanks.
Featured Gemstone of the week: Lava Rock
Lava rock beads are made of cooled molten lava. Lava beads full of little craters, very meteorite-like (nerdy-goodness). Beads are polished to remove any rough edges and coated with wax.
Featured Chain/Cord of the week: Greek Leather
We've restocked all colors of our Greek Leather collection. Available in 1.5mm, 2mm and 3mm round cord.
Known for its inherent flexibility, natural qualities, smooth finish, consistent color, and supple texture, Greek Leather Cord is perfect for high-quality beading applications.
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MassBlurb automates everything a restaurant needs in the social space and helps them create their brand presence and increase their overall business with innovative technology Mobikon , a customer engagement and marketing platform for restaurants ...Yahoo! Singapore, 1 month ago
Ridhima Pandit of Bahu Hamari Rajni_Kant wins first award
TV actress Ridhima Pandit, who plays the role of a robot in 'Bahu Hamari Rajni_Kant', is ecstatic as she has won her first award as an actress. Ridhima has made her debut with the hit serial in which she plays the role of a loveable robot. The show ...Times of India, 1 month ago
Plain cigarette packages come into effect UK, France
The days of branded cigarette packets in Britain and France are numbered as new plain packaging laws came into effect on Friday, hailed by anti-smoking campaigners despite resistance from tobacco firms. The logos and distinctive colours on ...Daily Sabah, 2 months ago Plain cigarette packs become law in UK, France Times of India, 2 months ago
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Their result for The BIG WORDS ARE SEXY Test ...
Vocabulary Vixen!
Congratulations! You got ### correct answers!
Their Analysis (Vertical line = Average)
They scored 15% on wordpoints, higher than 43% of your peers.
All possible test results
Raised By Wolves
You didn't get half of the questions correct. Either you are a complete idiot, or were raised by wolves and consider English your second language (howling at the moon being your first). Read more
The Bullshitter
You sprinkle big words throughout conversations in attempt to impress those around you. Unfortunately, you mispronounce those big words more often than not. You aren't fooling anyone, buddy. Read more
Making Me Moist!
You are close, but no cigar. Consistency and effortlessness are crucial to wowing me with words. A good attempt. Read a book or two (like the dictionary) and try again when you have more confidence. Read more
Vocabulary Vixen!
You sexy thing! You probably own a book or two. You can communicate in complete thoughts and your knuckles don't drag while walking down the street. Now promise me you will use your word power for goo... Read more
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Today's ReportSunday 07/24/16 3:48 pm
|Location: C-Street
|Size: Knee/Thigh High
|Surface: Choppy
|Wind: SSW @ 15-20
|High Tide: 11:49:00 PM
|Low Tide: 5:36:00 PM
|Water Temp: 84.4 °F
|Sunrise: 6:16:00 AM
|Sunset: 8:18:00 PM
Afternoon Update: Looking slightly better now that the tide is bottoming out. There is a wave here and there that's rideable, but the conditions are pretty crummy. The sandbar isn't particularly good, and the wind is blowing it to bits. Giving it half a logo solely because you cold surf if you had to. Only one guy was out when I did the report. Not sure if it'll get much better before dark, but keep an eye out on our live cam for any changes. Have a great day.
Surfing Code Of Ethics! 2016 WB Surfing Regulations and Zones.... HERE! Forget your leash? Just stop by Sweetwater and leave your license to borrow one.
Sweetwater's Specials - Men's wovens and polos 20% off, SS Tees and tanks 25% off, and boardshorts and hybrids are 30% off. Women's swim is buy item and get the second 50% off. All boy's and girl's clothing is 30% off. All backpacks and Nixon watches are 20% off too! We still have some "gift with purchases" with Stance, Oneill clothing, and Smith Optics from the weekend so come check those out before they're all gone!


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Interaction between metabolism and flow in tendon and muscle
Version of Record online: 7 JUL 2008
DOI: 10.1034/j.1600-0838.2000.010006338.x
Scandinavian Journal of Medicine & Science in Sports
Volume 10, Issue 6, pages 338–345, December 2000
Additional Information
How to Cite
Clark, M. G., Clerk, L. H., Newman, J. M. B. and Rattigan, S. (2000), Interaction between metabolism and flow in tendon and muscle. Scandinavian Journal of Medicine & Science in Sports, 10: 338–345. doi: 10.1034/j.1600-0838.2000.010006338.x
Publication History
- Issue online: 7 JUL 2008
- Version of Record online: 7 JUL 2008
- Accepted for publication 6 April 2000
- Abstract
- Cited By
Blood vessels supplying the musculotendinous region of tendons, including interfibrillar connective tissue, represent a parallel vascular network to that supplying muscle fibers. Reciprocal control by vasomodulators and neural input determines relative flow in each network, and therefore relative supply of nutrients and hormones. Vessels supplying the tendon support fat cells and may function as a non-nutritive network within muscle groups to regulate resting muscle energy metabolism and to act as a flow reservoir for nutrient delivery in exercise.


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competitions and did well Since I have owned him...I have been to a few fun shows. He is very well behaved I m$2,500
, clips, easy to handle and is smooth going down the trail. He is a gelding and current on shots$4,000
JT is a nice young gelding with 8 mons of training. He s been on several trail rides and also$5,500
Excellent Frisian Gelding horse for sale, with a deep black or a correct body style and good length$2,500
Hi I am looking for a pasture mate for my colt who will soon be gelded he is one and and can$900
ridden english and jumped. Also does some tricks such as retrieve, sit, bow, and " play " the guitar$6,000
Advanced rider looking for a new performance horse. My daughter is active in Pony Club and has been in regular lessons for nine years. She has qualified…No Price Listed
Cheddar is a friendly, laid back boy. He s a stout built easy keeper. He s nice for the farrier and is kept in a barefoot trim. He stands, ties and loads…$1,200


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- Swimmer Ryan Lochte reveals one of his worst dates - US Weekly
- Get the latest on Dr. Dre's arrest - TMZ
- Despite rumors, Eddie Murphy's daughter is not pregnant - Gossip Cop
- The Vampire Diaries star Michael Trevino steps out for a good cause - Just Jared Jr
- Are Blac Chyna and Kylie Jenner on good terms? - Radar
- Blue Ivy is just as stylish as her mom Beyonce! - Lainey Gossip
- This Narcos star confirms he's not coming back for another season of the show - The Hollywood Reporter
17 November 2011 at 2:43 PM
Jennifer Garner & Seraphina: Huckleberry Duo!
About this photo set: Jennifer Garner takes her adorable daughter Seraphina for lunch at Huckleberry restaurant on Wednesday (November 16) in Santa Monica, Calif. The 39-year-old pregnant… Read More Here
Photo #: 2601297
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115 total
I am recently a 39 year old widow. There is no life insurance. He has individual debt as do I , we have a mortgage that I am unable to pay monthly. I do work, but my salary is not enough to meet the mortgage and monthy expenses.
You do need to list all assets and debts. However you can keep your car and typically you will not lose assets. Court will look at equity in assets and income compared to expenses to determine if you can eliminate the debtSee question
I recently filed for Bankruptcy, 2 months later I got a letter on the mail saying that one of my creditors is challenging my case, using rule 2004 examination? Can anybody tell me what this is? Also, my attorney is asking for another substantial...
A creditor does have a right to take your deposition to determine whether your bankruptcy schedules accurately reflect your assets and to determine whether there is a basis to object to your ability to discharge their claim or all of your claims. Even when a bankruptcy is filed, you must still meet certain obligations before you can receive your discharge. The creditor's ability to object is somewhat limited, so just because they are taking your deposition does not mean in the end you will not be able to obtain discharge.See question
I have a friend that is in a situation, my brother is in over 26k personal dept with credit card company and other bills that are in collections. He is about 66K in dept including student loans. The major problem is he is in criminal court for "ba...
Your friend can file bankruptcy, but that does not necessarily solve his problems. It will not stop the criminal matter from going forward against him. Any award of restitution would not be eliminated in bankruptcy. In addition, the creditors that were defrauded can object to their claims being discharged in bankruptcy. It may be a circumstance where bankruptcy can be filed to eliminate some of the debts which will make it easier to address any claims that are not dischargeable. Your friend should consult with an experienced bankruptcy attorney to see if bankruptcy makes sense.See question
Beneficiary of 401a I'd I rollover to ilunherited Ira to
The ability to exempt an inherited IRA depends on whether it is inherited from a spouse or someone else. The Supreme Court ruled that an IRA inherited from a parent is not protected. However, since then several courts have said if inherited from a spouse it is protectefSee question
I have just recently bought a house (my parents are paying for it). It's in my name. It technically isn't mine yet because there is still a balance on the mortgage but I'm doing owner financing. I want to file for bankruptcy but scared they will t...
Owning real estate does not prevent you from filing bankruptcy nor does it mean you will lose your house. You are allowed to protect some equity in your home when you file a bankruptcy. Your circumstances raise some additional questions such as whether the mortgage on the house is in your parents names or whether they are holding the mortgage and if they are did they properly record the mortgage. I would suggest you consult with experienced bankruptcy attorney to determine whether bankruptcy would work for you.See question
I have been on a payment plan with the IRS for several years. I was told that if the IRS fails to collect taxes due for a certain year and five years have passed, those taxes are no longer collectible if I file for bankruptcy.
In certain circumstances the answer is yes. It depends on a number of factors. For example is it personal income tax or is it personal liability on some other tax such as 941 taxes. In addition, has the internal revenue service filed a federal tax lien. If they have, and there is equity in the assets for the lien to attach, then even if the tax would have been dischargeable because of its age it would not be eliminated as a lien on your property. The bottom line is older taxes may be dischargeable, but you need to consult with an experienced bankruptcy attorney to determine whether they would be in your particular case.See question
Can I file and get chapter 7 bankruptcy while working part time. Grossing 900 a month?
Courts look at income and expenses as well as assets and liabilities among other things to determine eligability. Assuming you have living expenses, I would not anticipate your income would prevent you from filing chapter 7. I suggest you contact an experience bankruptcy attorney to discuss.See question
If I file Chapter 11 as an individual and want to turn in my car lease, will it negatively impact the person who co-signed with me? He didn't file for bankruptcy (we're not married) but he is on the lease as well. I had never been late so there's ...
Not only will it negatively impact his credit, but the leasing company will be able to sue him for any deficiency claim. I suggest you consult with an attorney that has experience in representing individuals in personal Chapter 11 cases, as their are a number of issues to deal with beyond what would be required in a Chapter 13 bankruptcy.See question
Would my creditor just took All of my income?
No. You are allowed to have a job and file bankruptcy. The court will consider the equity in assets and income compared to expenses among other things in determining whether you can eliminate your debt or whether you need to pay something to your creditors. Many bankruptcy attorneys will provide a free consultation to help you determine your eligibilitySee question
I'm behind in my mortgage for about 5 years and I like to file Chapter 7 Bankruptcy since I owe about $400,000 and the current value of the home is about $220,000. If I don't re-affirm the mortgage, will the Trustee attempt to sell my home or will...
The Chapter 7 will actually slow down the foreclosure since it cannot proceed while the bankruptcy stay is in effect. A creditor would need to ask court for permission to continue or wait for end of case. Trustee will generally not try and sell since there is no equity. Trustee job is to sell asset if sale will result in payment to creditors, which would not happen here.See question


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The Evergreen Fire Protection District board discussed the district's financial situation June 16, including the plan to seek a property-tax increase and bond issue on the November ballot.
At the meeting, the fire district formally introduced Webb Strategic Communications — the public relations firm it will work with to inform residents about the need for more revenue. Pete Webb, president of the firm, will lead the campaign, which kicks off with a town hall meeting Thursday.
Jeffco Public Schools may be drafting a policy on medical marijuana after Gov. John Hickenlooper signed legislation that requires the state's districts to allow use of the remedy on school grounds.
"Jack's Law" law requires school districts to "adopt a policy permitting the use of medical marijuana by students authorized" to use it. The legislation was named for Jack Splitt, a Wheat Ridge middle school student with cerebral palsy whose medical marijuana was confiscated last year by school officials.
Smoke visible in the Evergreen and Conifer area is not from a local fire but rather the result of major wildfires burning in New Mexico and Arizona.
According to Curt Rogers, fire chief at the North Fork Volunteer Fire Department, smoke from the Dog Head Fire in New Mexico, as well as the Cedar Creek Fire in Arizona, is drifting into Colorado and causing visibility issues. Rogers also said that a 700-acre wildfire at Fort Carson also could be contributing to the visibility issues.
Pine Grove's 29th annual Rhubarb Festival was a hot one — from scorching temperatures to a parade featuring the chrome bumpers of classic cars to the unusual dish that won the annual bake-off, it was a weekend burned into memory.
About 30 horses and their riders returned to scattered cheers at the Evergreen Rodeo Grounds after a two-hour fund-raising trail ride Sunday. Led by Evergreen Rodeo Association president Mark Johnson, the Heritage Ride kicked off the start of Evergreen Rodeo week by supporting the Colorado Horse Council.
The Evergreen Rodeo is celebrating its 50th anniversary with a weekend packed with excitement and entertainment Friday through Sunday.
"It's one thing to slap a board on your feet and slide down a mountain; it's another thing to get on a 2,000-pound bull," said Evergreen Rodeo Association president Mark Johnson. "This is an extreme sport, so if you want to see athleticism and if you want to see danger, if you want to see unpredictability, it is all wrapped up in about a two-hour rodeo."
The motorist accused of hitting a sheriff's deputy in March at the scene of a massive pileup on eastbound I-70 at the Lookout Mountain exit had his first court appearance June 6.
Robert Landsperg, a former Colorado resident now living in California, faces charges of leaving the scene of an accident, failure to report an accident, careless driving and careless driving resulting in injury.
Next year, almost 30 schools in the Jeffco district will see new faces filling assistant-principal and principal positions. Nine of those roles are being filled by new hires, while the rest are school-based administrative transfers.
Two Evergreen schools will have new leadership at the start of the 2016-17 academic year: Kathleen Piane will fill a new assistant principal position at Evergreen Middle School, and Brandon Brekke will take over as principal at Evergreen High.
A Lookout Mountain woman has been arrested on suspicion of first-degree murder and child abuse in the death of her 3-month-old infant.
The Jeffco Sheriff's Office said it received a 911 call at 11:30 a.m. May 20 about an infant who was not breathing. Officers and medical crews who responded to an address on Lookout Mountain Circle found the infant unresponsive and started CPR. The child was transported to a hospital, where he was pronounced dead.
An Englewood man was killed Saturday when his motorcycle collided with a car at Kings Valley Road and U.S. 285, according to the Colorado State Patrol.
James Ellison, 68, died at the scene after his motorcycle collided with a 2007 Honda Civic driven by Dillon Tussey, 22, of Evergreen at 12:05 p.m. Ellison was driving a 2006 Harley-Davidson south on U.S. 285 when it collided with the Honda Civic as the car attempted to turn from Kings Valley Road onto U.S. 285.
Copyright © 2016
Canyon Courier is your source for local news, sports, events, and information in Evergreen, Colo, and the surrounding area.


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The Week In Unbelievably Gorgeous Screenshots: Bioshock And Mass Effect 2
Since we ran a feature on Duncan Harris, the groovy "video game photographer" behind the website DeadEndThrills, I've been sharing some of his work each week here.
Nintendo Hopes Newest Mario Game Is The Series' Missing Link
Super Meat World Delivers Level Editor To Super Meat Boy Gamers
Mario, Wario Games Headline Nintendo's Summer Line-Up - Rhythm Tengoku MIA
Nintendo of America took June off. Today we've learned they're taking July off too. But in August the publisher will once again release new Wii and DS games from sea to shining sea.
Announced today are:8/25 – Mario Super Sluggers – Mario and friends playing baseball via the Wii (developed by Namco Bandai) 9/8 – Mystery Case Files: MillionHeir — A DS edition of the popular PC hidden picture series from Big Fish Games 9/29 – Wario Land: Shake It! — A side-scroller for the Wii (Developed by I-don't-know-who) 9/29 – Kirby Super Star Ultra — A DS remake of the 1996 SNES platformer, with touch-based mini-games added
Someone please console me that the DS sequel to Rhythm Tengoku, a rhythm game made by the makers of WarioWare, that's set for summer release in Japan, was not announced as part of this line-up.
Also note, Nintendo owners, that the baseball game is from Namco Bandai, one of these games is a remake and another is possibly being made by Big Fish. It certainly appears that Nintendo's internal teams, whose most recent work was May's Wii Fit, should be on deck for a lot of games in the fall.
Full press release after the jump.


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#TheMJs, July 29, 2016
Each week, Marcus Jackson gives us the best Twitter has to offer. Follow him at @MarcusJ_NG
This week's top tweets:
Joan Griffis/Illinois Ancestors: Holocaust-era assets are now online
A "substantive research interest in Holocaust-Era Assets began in 1996 with various issues related to Swiss dormant bank accounts and gold looted by Nazi Germany.
Verizon buys Yahoo for $4.83 billion, marking end of an era
MICHAEL LIEDTKE, AP Technology Writers
TALI ARBEL, AP Technology Writers
'Pokemon Go' players stumble on hidden history
PROVIDENCE, R.I. (AP) — Historical markers have long dotted the landscape, often barely noticed by passers-by — until they became treasure-filled stops this month on the "Pokemon Go" trail.
Wired-In: Julian Sanchez
On Sundays, staff writer Paul Wood spotlights a high-tech difference-maker. This week, Julian Sanchez, 38, wants to make your lawn look good. He has a Ph.D. in human factors psychology from Georgia Tech with an engineering background.
#TheMJs, July 22, 2016
Each week, Marcus Jackson gives us the best Twitter has to offer. Follow him at @MarcusJ_NG
This week's top tweets:
The black boxes on airplanes are made of Jameson Taillon
McDonald's joins "Pokemon Go" craze hoping to catch the wave
MAE ANDERSON, AP Technology Writer
NEW YORK (AP) — McDonald's will become the first major corporation to collaborate of e makers with the wildly popular "Pokemon Go."
Hackers access Illinois voter registration database
SPRINGFIELD, Ill. (AP) — Illinois election officials say hackers attacked the state's voter registration system last week and it was shut off as a precaution.
Rich Warren: Reader emails: Knowledge is power
Living in a high-tech hub such as Champaign-Urbana accrues many benefits. One of those is highly knowledgeable readers. We recently wrote about "just a few major companies" manufacturing the majority of lithium batteries. A reader, who makes his living involving batteries, responded:
Twitter cheers the news of new UI chancellor
What they tweeted after Robert Jones was named the next chancellor at the University of Illinois:


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5 of 5 people found the following review helpful
Great cookbook,
Verified Purchase(What's this?)
This review is from: Dirt Candy: A Cookbook: Flavor-Forward Food from the Upstart New York City Vegetarian Restaurant (Paperback)
I'm biased because I've eaten at Dirt Candy, and love the food there. I also read a lot of indy comic books - I suggest Kate or Die if you find a copy, so I love the graphic novel format Amanda Cohen, Dunlavey, and Hendrix use. I was first introduced to Amanda's cooking through the Iron Chef episode, and I love the history she provides in this book along with her cooking methods.
Super +1 - she gives the complete recipe for the smoked cauliflower and horseradish sauce with waffle dish, which is my favorite of her dishes.
One improvement would be to let us know what her pickling spice breakdown is for the pickled shiitake recipe. I do understand everyone has their own pickle spice ratio they think is best, but I would love to know Ms. Cohen's particular blend.
Review Details
Top Reviewer Ranking: 31,650,591


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CBI finds pistol of slain DSP
Top Stories
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In a breakthrough in the Pratapgarh triple murder case, the CBI Saturday recovered DSP Ziaul Haque's service pistol (.9mm calibre) and three empty shells related to the murder of village pradhan Nanhey Yadav from bushes in Balipur village where Yadav, his brother Suresh and the police officer were shot dead on March 2.
The recovery of the firearm and the shells, confirmed by CBI spokesperson RK Gaur, were made following interrogation of the pradhan's son and brother Pawan and suspended station officer (SO) of Hathigawan police station Manoj Shukla. The cartridges in the pistol belonging to Haque, who was the circle officer, have been found intact, which suggested that no gunshot was fired from the weapon, the sources said.
The pistol was found missing when the police had reached the spot after Haque's murder. His cellphone is also missing since then.
Meanwhile, two of the main accused named in pradhan Nanhey Yadav's murder case Kamta Pal and his son Ajay Pal appeared before CBI Saturday morning. They were absconding since the pradhan was shot dead. The two were undergoing interrogation.
The police officer's pistol and one empty shell of .315 bore and two of .38 bore were recovered from the bushes at a secluded place, which is about 20 metres away from the spot where the pradhan was shot dead. The bushes are about 500 metres away from the spot where Haque's body was found and the place is in opposite direction.
Both, the firearm and the shells were lying in the same bushes, added the sources.
The CBI team began a search for the pistol this morning after pradhan's son and brother Pawan reportedly told the agency that the pistol might be recovered somewhere in or around the village. They also had told the CBI officials that then SO Manoj Shukla can also help tracing the weapon. Shukla too was questioned and he was taken along during the search operation.
... contd.
Editors' Pick
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- A host of powerful open and programmable capabilities is set to create the 'WhatsApp moment' for Indian banking


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|By Marketwired .
Article Rating:
|April 1, 2014 01:04 AM EDT
EDMONTON, ALBERTA -- (Marketwired) -- 04/01/14 -- Mindoro Resources Ltd. (TSX VENTURE: MIO)(FRANKFURT:WKN 906167)(ASX: MDO) ("Mindoro", or "the Company") today announced the filing of the Company's annual audited financial results for the year ended December 31, 2013. Highlights in this news release should be read in conjunction with the Company's Annual Audited Financial Statements and the Management Discussion and Analysis, which are available on SEDAR at www.sedar.com. All dollar amounts are in Canadian dollars unless otherwise stated.
At December 31, 2013, Mindoro's cash balance was $198,000 and working capital deficit was $1.1 million. After-tax loss of $20.0 million in 2013 represents an increase compared to the net loss in 2012 of $8.8 million. The Company recognized an impairment loss of $8.2 million on its investment in Red Mountain Mining and $10 million loss on its Agata and Surigao Regional projects. Operating expenses were lower in 2013 ($1,131,000) than in 2012 ($2,417,000) as significant reductions were made in salaries and general and administrative costs.
Highlights During 2013:
-- An updated Resource Estimate filed for Agata North. -- Agata Nickel Project pilot plant was commissioned and pilot plant testing commenced. -- Agata high-iron laterite DSO Feasibility Study was released, demonstrating robust economics. -- Renegotiated an option to acquire additional 25% interest in the Agata projects from Minimax Mineral Exploration ("Minimax"). -- Negotiated the return of Tapian San Francisco tenements from Red Mountain Mining in exchange for return of four million Red Mountain shares. -- Raised $175,000 through private placement loans. -- Prime Resources Holding, Inc., ("PRHI") acquired 68.4% interest in Mindoro's joint venture partner, TVI Resource Development (Phils.), Inc.
Highlights Subsequent to 2013:
-- First nickel production from the Agata joint venture's pilot plant in Manila, Philippines. -- PRHI acquired 25% of Mindoro's common shares through secondary trades in the market. -- Mindoro sold 51.8 million Red Mountain shares for net proceeds of $879,000.
Milestones Targeted for 2014:
-- Establish direct shipping ore ("DSO") production at Agata. -- Advance Agata preferred processing technology to pilot testing and complete a definitive feasibility study. -- Evaluate merits of using pyrite from the Pan de Azucar Project for sulphuric acid production at the planned Agata nickel laterite processing operation. -- Finalize the option agreement with Minimax to acquire its 25% interest in the Agata project.
Commenting on the year end results, Mindoro's CEO Tony Climie said, "2013 was a challenging year as we sought to rebuild value in the Company. Although delays with the Agata DSO operation hindered our efforts, we are optimistic that 2014 will be a pivotal year for us. We are particularly pleased to welcome PRHI as a strong local partner and a strong shareholder in our company. We believe PRHI's investment sends a significant message of support for the Agata Project as well as the underlying value of our Company."
On behalf of the Board of Directors,
Tony Climie, CEO
About Mindoro
Mindoro is a Tier 1 Issuer trading on the TSX Venture Exchange (MIO), Australian Securities Exchange (MDO) and Frankfurt Stock Exchange (WKN 906167). Mindoro has a 75% interest and an option to acquire the remaining 25% in the Agata Nickel Project, Mindanao, and the Pan de Azucar Sulphur-Copper-Gold Project, Iloilo. TVIRD has the option to earn up to a 60% interest in these projects by meeting the earn-in requirements outlined in the June 24, 2013, release. Mindoro also holds a 6.4% stake in ASX listed Red Mountain Mining (ASX: RMX), which has a 100% direct and indirect interest in the Batangas gold and copper-gold projects.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Tony Climie P.Geol., is the CEO of Mindoro Resources Ltd and has sufficient experience which is relevant to the style of mineralization and type of deposit under consideration and to the activity which he is undertaking to qualify as a qualified person as defined by National Instrument 43-101. Tony Climie consents to the inclusion in the report of the matters based on the information in the form and context in which it appears.
This release may contain forward-looking statements including management's assessments of future plans and operations, and expectations of future production. These statements are based on current expectations that involve a number of risks and uncertainties, which could cause actual results to differ materially from those anticipated. These risks include, but are not limited to, the risks associated with the mining and exploration industry (e.g. operational risks in development, exploration and production; delays or changes in plans with respect to exploration or development projects or capital expenditures; the uncertainty of reserve estimates; the uncertainty with respect to results of exploration, the uncertainty of estimates and projections relating to production and the uncertainty of the availability of capital). The assumptions used in the preparation of such statements, although considered reasonable at the time of preparation, may prove to be imprecise and, as such, undue reliance should not be placed on forward-looking statements. The Company does not undertake to update forward-looking statements except where required to do so by law.
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text:
Oxfordshire Under 13s will go for glory on Sunday when they play in the National Shires finals day at Walsall.
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It was their highest finish in an under 14 competition.
Oxfordshire squad: M Boyd (Chalgrove), H Craig (Sutton Courtenay), S Gujral (East End), S Khimji (Didcot), M Marriott (Didcot), C Mitchell (Woodstock), J Moreton-Smith (Abingdon), J Redfern (Boars Hill), E Rose (Oakley), D Worth (Abingdon).
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text:
The channel protein Pannexin1 keeps nerve cells flexible and thus the brain receptive for new knowledge. Together with colleagues from Canada and the U.S., researchers at the Ruhr-Universität Bochum led by the junior professor Dr. Nora Prochnow from the Department of Molecular Brain Research describe these results in PLoS ONE.
Micrograph of the hippocampus: The blue curves show the long-term potentiation in mice with (left) and without Pannexin1 (right). Brains of animals without the channel protein respond especially sensitively to small stimuli, as the big difference between the light and dark blue curve shows. The data is based on original measurements of the study.
Image: Nora Prochnow
In the study, mice comprising no Pannexin1 in memory-related brain structures displayed symptoms similar to autism. Their nerve cells lacked synaptic plasticity, i.e. the ability to form new synaptic contacts or give up old contacts based on the level of usage.
Pannexins are abundant in the central nervous system of vertebrates
Pannexins traverse the cell membrane of vertebrate animals and form large pored channels. They are permeable for certain signalling molecules, such as the energy storage molecule ATP (adenosine triphosphate). The best known representative is Pannexin1, which occurs in abundance in the brain and spinal cord and among others in the hippocampus - a brain structure that is critical for long-term memory. Malfunctions of the pannexins play a role in the development of epilepsy and strokes.
No more scope in long-term potentiation
The research team studied mice in which the gene for Pannexin1 was lacking. Using cell recordings carried out on isolated brain sections, they analysed the long-term potentiation in the hippocampus. Long-term potentiation usually occurs when new memory content is built - the contacts between nerve cells are strengthened; they communicate more effectively with each other. In mice without Pannexin1, the long-term potentiation occurred earlier and was more prolonged than in mice with Pannexin1. "It looks at first glance like a gain in long-term memory", says Nora Prochnow. "But precise analysis shows that there was no more scope for upward development." Due to the lack of Pannexin1, the cell communication in general was increased to such an extent that a further increase through the learning of new knowledge was no longer possible. The synaptic plasticity was thus extremely restricted. "The plasticity is essential for learning processes in the brain", Nora Prochnow explains. "It helps you to organise, keep or even to forget contents in a positive sense, to gain room for new inputs."
Autistic-like behaviour without Pannexin1
The absence of Pannexin1 also had an impact on behaviour: when solving simple problems, the animals were quickly overwhelmed in terms of content. Their spatial orientation was limited, their attention impaired and an increased probability for seizure generation occurred. "The behavioural patterns are reminiscent of autism. We should therefore consider the Pannexin1 channel more closely with regard to the treatment of such diseases", says the neurobiologist from Bochum.
Theory: feedback regulation gets out of hand without Pannexin1
According to the scientists' theory, nerve cells lack a feedback mechanism without Pannexin1. Normally the channel protein releases ATP, which binds to specific receptors and thus reduces the release of the neurotransmitter glutamate. Without Pannexin1 more glutamate is released, which leads to increased long-term potentiation. This causes the cell to lose its dynamic equilibrium, which is needed for an efficient learning process.
Bibliographic record
N. Prochnow, A. Abdulazim, S. Kurtenbach, V. Wildförster, G. Dvoriantchikova , J. Hanske, E. Petrasch-Parwez, V.I. Shestopalov, R. Dermietzel, D. Manahan-Vaughan, G. Zoidl (2012): Pannexin1 stabilizes synaptic plasticity and is needed for learning, PLoS ONE , DOI: 10.1371/journal.pone.0051767
Further information
Prof. Dr. Nora Prochnow, Department of Molecular Brain Research, Faculty of Medicine, 44780 Bochum, Germany, Tel. +49/234/32-24406, E-Mail: firstname.lastname@example.com
Editor: Dr. Julia Weiler
Dr. Josef König | idw
Further information:
Further reports about: > Brain > Brain Research > Molecular Brain Research > Molecular Target > PLoS One > Pannexin1 > Prochnow > learning process > long-term memory > long-term potentiation > nerve cell > ong-term potentiation > synaptic plasticity
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text:
Norah Jones Not Too Late
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CD Details
- Released: January 30, 2007
- Label: Blue Note Records
Entertainment Reviews:
Rolling Stone - p.663 stars out of 5 -- "[S]he's quirkier lyrically than any of her helpmates. And she remains pop's nicest superstar..."
Entertainment Weekly - p.122"NOT TOO LATE has a slightly, rougher, home-studio sound....[With] slow, gorgeous dream-pop ballads..." -- Grade: B-
Q - p.983 stars out of 5 -- "[An] understated blend of country, folk, jazz and soul....Simple songs, lovingly crafted and sweetly sung."
Uncut - p.754 stars out of 5 -- "[S]omething altogether fresh....Just like that, Jones transforms herself into the gentlest of cutting-edge artists."
Down Beat - p.58"Jones still favors gentle love songs, tunes streaked with a mix of nostalgia and hope, and her elegant amalgam of acoustic pop, soft focus country and polished blues still goes down like a spoonful of sugar."
No Depression - p.108"NOT TOO LATE operates from an intimate stance.....Acoustic textures and bone-dry vocals draw the focus to the tune..."
Mojo (Publisher) - p.1044 stars out of 5 -- "Jones has reclaimed her music on her own terms, establishing a new level of artistry with a fascinating line in subversion of the politest kind."
- 1.Wish I Could
- 2.Sinkin' Soon
- 3.The Sun Doesn't Like You
- 4.Until the End
- 5.Not My Friend
- 6.Thinking About You
- 7.Broken
- 8.My Dear Country
- 9.Wake Me Up
- 10.Be My Somebody
- 11.Little Room
- 12.Rosie's Lullaby
- 13.Not Too Late
Product Description:
Personnel: Norah Jones (vocals, piano, Wurlitzer piano); Daru Oda (vocals, whistle); Jesse Harris (acoustic guitar); Adam Levy (electric guitar); Kevin Breit (mandolin); Julia Kent, Jeffrey Zeigler (cello); Larry Goldings (Hammond b-3 organ); Lee Alexander (bass instrument); Andrew Borger (drums).
For a young and commercially successful artist, Norah Jones has admirably avoided playing it too safe. After scoring an unlikely sales sensation and multiple Grammy award winner with 2002's torchy COME AWAY WITH ME, Jones shifted gears slightly to accent that album's country and folk elements on the 1970s-styled follow-up, FEELS LIKE HOME. Following that, Jones deliberately played with expectations, first becoming a low-key sideman in a quirky alt-country band called the Little Willies, then playing the lead role in a new movie by Hong Kong arthouse director Wong Kar-Wai.
Jones's third album, NOT TOO LATE, is perhaps not as extreme as any of those other moves away from her initial comfort zone, but it's a departure nonetheless. Recorded by Jones and longtime collaborator Lee Alexander in their home studio and featuring only self-penned material, NOT TOO LATE is far less polished than Jones's previous records, with many songs featuring little more than the singer's familiar croon, a Floyd Cramer-influenced piano, and Alexander's subtle bass. Not quite jazz, country, or pop, NOT TOO LATE fuses all of Jones's influences into an immediately identifiable whole. It's easily her most mature and personal album to date.
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text:
Philips launches GoGear Opus
Philips unveiled its new top-of-the range GoGear personal media player at its press event in Lisbon today, called the GoGear Opus.
Packing an impressive 2.8-inch QVGA screen, the Opus adds on some extra functionality to the also-announced Ariaz.
To begin with, the Opus is the largest PMP in the GoGear range - but remains thin and lightweight.
It provides the benefits of "FullSound" technology, combined with HD sound isolation headphones, meaning the sound is much louder and clearer.
Other features of the Opus include Bluetooth stereo audio output, easy download of open source videos using the included software, FM radio and a microphone for voice and radio recording.
The Opus also supports BBC iPlayer for watching back your favourite BBC shows.
The GoGear Opus will be available in April in 8GB, 16GB and 32GB capacities. European prices have been announced at 99 euros, 147 euros and 179 euros respectively.
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