text:
Relevant offers
John Carver looks little in real life. Talks a massive game, though.
Fabricio Coloccini has to be one of the best players to ever grace these shores and Alan Pardew seemed exceedingly nice. Particularly given he's in that elite club of Premier League managers to headbutt an opposition player.
Dull doesn't doesn't do justice to the tedium of most training sessions. But, without wanting to wave the pom poms too hard, it was a privilege to watch Newcastle United knock it about at Newtown Park yesterday.
The sheer pace and quality of proceedings would have been the main things the appreciative crowd of about 200 took away. As one journalist remarked, following the first of many cracking goals, he'd seen more skill in that display of one-touch passing and finishing than in three years watching the Wellington Phoenix train.
It wasn't a slight on our local lads. Just an honest observation about the gulf in ability that exists between our players and the best the British pound can buy.
It was Carver who kept yesterday's standards up. Geordie born-and-bred, he first became assistant manager under Bobby Robson in 1999.
Carver's in that bracket of "you'd know him if you saw him" types. If he had a pound for all the times he's been captured wandering out to the technical area to whisper in the "gaffer's" ear, he'd be the richest man in the Magpies' touring party.
"The pitch is lively, you can see that. Take some care," Carver bellowed at his boys.
It actually looked a picture but, by the standards these blokes are used to, the surface was apparently bumpy.
"You can see it's quite lively, so you've really got to take care. Good players can play on anything," he said again, when someone's touch deserted them for once.
It definitely wasn't Coloccini. The Newcastle captain, capped 34 times by Argentina and an old boy of such clubs as AC Milan and Atletico Madrid, did genuinely dazzling things at times. It's the attacking players that are meant to be good on, and with, the ball, but the ringlet-haired defender had it on a string.
And then there was Pardew. Before a ball had been kicked, he was over introducing himself to the fans and offering one-liners to the media.
He soon copped something similar from Coloccini. Having attempted to curl one into the top corner of an open goal, Pardew's shot hit the crossbar. The laughing skipper told all and sundry that meant a £10 fine for the manager.
"Yeah, 10 New Zealand pounds," Pardew fired back.
For a man among the favourites to be the first manager sacked in the coming season, Pardew seemed remarkably relaxed.
You could've happily watched the Magpies train for hours. Sadly 90 minutes was all you got, which meant one last thing.
"Once you've done your stretches you're going across to the far side for autographs. Even if you don't want to," said Carver.
If any of the squad did it under sufferance, it didn't show. Pardew even staged a race between some South Wellington Intermediate School pupils, after telling them the first one to retrieve a ball he'd gently kicked could keep it.
Let's hope it's not another 19 years till Newcastle are back in Wellington.
- The Dominion Post
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|• Section 80C
|• Section 80CCC
|• Section 80CCD(1)
|● Section 80CCD(2)
|● Section 80CCD
|● Section 80CCG
|● Section 80D
|● Section 80DD
|● Section 80DDB
|● Section 80E
|● Section 80G
|● Section 80EE
|● Section 80G
|● Section 80GG
|● Section 80GGA
|● Section 80GGC
|● Section 80RRB
|● Section 80QQB
|● Section 80TTA
|● Section 80U
|● Section 24
The aggregate of total deduction available under sections 80C, 80CCC and 80CCD is limited to whole of the amount paid or deposited subject to a maximum of Rs. 1,50,000/- for investment in one or more of the following :
Payment of premium for annuity plan of LIC or any other insurer Deduction is available upto a maximum of Rs. 150,000/-.
The premium must be deposited to keep in force a contract for an annuity plan of the LIC or any other insurer for receiving pension from the fund.
Note: The limit for maximum deduction available under Sections 80C, 80CCC and 80CCD(1) (combined together) is Rs. 1,50,000/-.
Deduction available for the amount paid or deposited in a pension scheme notified or as may be notified by the Central Government subject to a maximum of :
(a) 10% of salary in the previous year in the case of an employee
(b) 10% of gross total income in any other case.
The maximum deduction allowable under the secion is Rs. 1.00 lac. Rs. 1.50 lacs w.e.f. 01.04.2015 in case of contribution to New Pension Scheme (NPS).
Deduction available for the amount paid or deposited by the employer of the assessee in a pension scheme notified or as may be notified by the Central Government subject to a maximum of 10% of salary in the financial year.
A deduction of upto Rs. 50,000 is available over and above the limit of Rs. 1.50 lakh in respect of contributions made to NPS under Section 80CCD(1).
50 per cent of amount invested by resident individuals, whose gross total income does not exceed Rs. 12 lakhs, in listed shares or listed units in accordance with notified scheme for a lock-in period of 3 years (Subject to certain conditions). Maximum deduction : Rs. 25,000/-.
Deduction is available upto Rs. 30,000/- (enhanced from Rs. 20,000 w.e.f. 01.04.2015) for senior citizens and upto Rs. 25,000/- (enhanced from Rs. 15,000 w.e.f. 01.04.2015) in other cases for insurance of self, spouse and dependent children. Additionally, a deduction for insurance of parents (father or mother or both) is available to the extent of Rs. 30,000/- (enhanced from Rs. 20,000 w.e.f. 01.04.2015) if parents are senior Citizen and Rs. 25,000/- (enhanced from Rs. 15,000 w.e.f. 01.04.2015) in other cases. Therefore, the maximum deduction available under this section is to the extent of Rs. 60,000/- in case of individuals and Rs. 30,000/- in case of HUFs. From AY 2013-14, within the existing limit a deduction of upto Rs. 5,000 for preventive health check-up is available.
Deduction of Rs. 75,000/- (enhanced from Rs. 50,000 w.e.f. 01.04.2015) in respect of
Further, if the defendant is a person with severe disability a deduction of Rs. 125,000/- (enhanced from Rs. 1,00,000 w.e.f. 01.04.2015) shall be available under this section. The handicapped dependent should be a dependent relative suffering from a permanent disability (including blindness) or mentally retarded, as certified by a specified physician or psychiatrist. Note: A person with 'severe disability' means a person with 80% or more of one or more disabilities as outlined in section 56(4) of the 'Persons with disabilities (Equal opportunities, protection of rights and full participation)' Act.
A deduction to the extent of Rs. 40,000/- (Rs. 60,000 in case of senior citizen) or the amount actually paid, whichever is less is available for expenditure actually incurred by resident assessee on himself or dependent relative for medical treatment of specified disease or ailment. The diseases have been specified in Rule 11DD. A certificate in form 10 I is to be furnished by the assessee from any Registered Doctor.
Deduction in respect of interest on loan taken for pursuing higher education (subject to certain conditions) (maximum period : 8 years).
The deduction under this sub-section is available w.e.f. AY 2014-15. The maximum deduction available is Rs. 1 lac. In a case where the interest payable for the financial year 2013-14 is less than Rs. 1 lac, the balance deduction amount shall be available in AY 2015-16.
The deduction under sub-section (1) shall be subject to the following conditions :
If deduction for Housing Loan Interest is availed under this section, no deduction can be availed for such interest under any other provisions of the Act for the same or any other assessment year.
The various donations specified in Sec. 80G are eligible for deduction upto either 100% or 50% with or without restriction as provided in Sec. 80G
Deduction available is the least of
Maximum deduction Rs. 3,00,000/-
Maximum deduction Rs. 3,00,000/-
Deduction from gross total income of an individual or HUF, upto a maximum of Rs. 10,000/-, in respect of interest on deposits in savings account ( not time deposits ) with a bank, co-operative society or post office, is allowable w.e.f. 01.04.2012 (Assessment Year 2013-14).
Deduction of Rs. 75,000/- (enhanced from Rs. 50,000 w.e.f. 01.04.2015) to a resident individual who suffers from a physical disability(including blindness) or mental retardation. Further, if the individual is a person with severe disability, deduction of Rs. 125,000/- (enhanced from Rs. 1,00,000 w.e.f. 01.04.2015) shall be available u/s 80U. Certificate should be obtained from a Govt. Doctor. The relevant rule is Rule 11D.
Deduction in respect of Interest for Pre-construction Period: The interest payable by an assessee in respect of funds borrowed for the aquisition / construction of a house property and pertaining to the period prior to the previous year in which such property has been aquired of constructed, to the extent it is is not allowed as a deduction under any other provison of Income Tax Act, will be deducted in five equal installments commencing from the previous year in which the property is aquired or constructed.
All efforts are made to keep the content of this site correct and up-to-date. But, this site does not make any claim regarding the information provided on its pages as correct and up-to-date. The contents of this site cannot be treated or interpreted as a statement of law. In case, any loss or damage is caused to any person due to his/her treating or interpreting the contents of this site or any part thereof as correct, complete and up-to-date statement of law out of ignorance or otherwise, this site will not be liable in any manner whatsoever for such loss or damage.
The visitors may visit the web site of Income Tax Department for resolving their doubts or for clarifications.


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Traveling from Sacramento/SF area to Thailand in February. Do you recommend United or Cathay Pacific airlines? Have researched a few other airlines but most seem to be limited in flight choices. Dates for travel are not flexible.
Recent ActivityView all Air Travel activity »
- 1 Domestic layover on an international flight
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California to Bangkok
Traveling from Sacramento/SF area to Thailand in February. Do you recommend United or Cathay Pacific airlines? Have researched a few other airlines but most seem to be limited in flight choices. Dates for travel are not flexible.
Report Abuse
Check out their passenger trip reviews on http://www.airlinequality.com/
Report Abuse
If you are flying regular coach, CX will give you a better experience than UA. But if the price difference is large enough for you to purchase Economy Plus access on UA ($499/yr, also good for companion), then the extra legroom on UA may be of interest for you.
CX also have a true premium economy product, but not cheap.
If you're flying business or first class, then no contest, definitely CX.
Report Abuse
Thank you for your quick replies! Price is about the same so I thought if service was better with CX, I would try that airline. In general, I find international airlines are usually better than USA airlines but have only flown transAtlantic and not transPacific. I am a United mileage plus member and have found seating/service lacking (true of all airlines the past +5 years!).
Do you know if the clamshell seats have been replaced on all CX planes?
I welcome any other suggestions you regarding airlines, flights.
Thank you... the website was very helpful!
Report Abuse
The longhauls 777-300ER on CX don't have the shell seats anymore.
If you don't care about the miles in UA, or need to maintain elite status, then CX is clearly preferred. Do keep in mind that even though the fare you see may be similar, most discount CX fares only earn 50% miles, while UA is 100%.
Report Abuse
Thank you, rkkwan, for the tip.... I did not know! I was planning on accruing miles on my American Airline acct with CX flight. Went on CX website; how do you know what type of ticket you are issued (H, K< M< L< etc)?
Do not have elite status (72K miles), considered purchasing economy plus or ccard for United. Not sure it is worth the extra +$250 cost. Just looking for comfort and service on flight and, from experience, that usually means flying with non-USA carrier.
Thanks for your help.
Report Abuse
I have had a fabulous experiences on Asian carriers. In general I would recommend them highly. I not been on Singapore or Cathay yet but Malaysian is my all time favourite. A flight attendant sprayed a little soft drink on my white pants on a Japan Airlines flight and she was so apologetic. I said don't worry. She insisted repeatedly that I take the dry cleaning voucher she was offering and charge it back to JAL. I just took it to make her happy.
Happy travels!
Report Abuse
UA's E+ Access is worth it for 2 persons on 4 flights. And especially if you do fly on UA again within the coming year.
Report Abuse
The Singapore A380 via Hong Kong is another option. Get a preferred seat in economy for $50 more on the upper desk - lots of legroom
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Have you checked EVA Airlines? You can fly SFO-TPE-BKK with them. They also have a Premium Economy (called Elite). And they are now members of Star Alliance.
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MN Give To The Max Day Totals
The state's fifth annual Give to the Max Day had an overwhelming start, with more than $9-million dollars in donations made before lunchtime — but the high volume of traffic on the website dedicated to …15 Nov 13
Local News, Multimedia, Sports - The Local Connection
Wheeler Dealer
The state's fifth annual Give to the Max Day had an overwhelming start, with more than $9-million dollars in donations made before lunchtime — but the high volume of traffic on the website dedicated to …15 Nov 13
The 16-year-old Willmar boy charged with 2nd-degree murder for his alleged role in the strangulation and stabbing death of his friend's grandmother will stand for an adult certification hearing on December 10th. The date of …14 Nov 13
A 19-year-old Arlington woman is facing multiple felony charges in Sibley County Court, including manslaughter, after her 8-month-old child died over the weekend. Christina DeLeon was apparently giving both of her boys a bath at …14 Nov 13
A grand jury has indicted a Renville man on first-degree murder charges in the shooting deaths of his ex-girlfriend and her boyfriend. The Yellow Medicine County grand jury on Tuesday indicted 28-year-old Andrew Dikken on …14 Nov 13
The body found in a log jam on the Minnesota River on Saturday has been positively identified as missing kayaker Stephen Fritze. The Ramsey County Medical Examiner has confirmed the identity of the body following …14 Nov 13
Windy weather and standing corn put a damper on the opening of Minnesota's firearms deer season this past weekend. The DNR says the harvest for the first three days was down 8% from 2012. Hunters …14 Nov 13
The deadline is approaching to nominate a favorite teacher as the Minnesota Teacher of the Year. Education Minnesota says nominations will be accepted through the end of the day Friday. Simple nomination forms are available …14 Nov 13
The New Ulm Medical Center announced the latest recipient of the hospital's annual "Legends Award" on Tuesday. Dr. Robert Trautloff is being honored for making a positive difference in people's lives with his skill, talent …14 Nov 13


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LED Industrial Mini Flashlight, Stainless Steel, Maximum Lumens Output: 340, Silver, 4.75"
- Item# 21EK89
- Mfr. Model# A22R
- Catalog Page# N/A
Using 360° Viewing:
- Rotate: Use top-to-bottom, side-to-side by use of mouse arrow.
- Zoom In: Double click on image.
- Zoom Out/Reset: Put photo at full zoom & then double click.
- Shipping Weight 1.25 lbs.
Technical Specs
- Item Mini Flashlight
- Flashlight Grade Industrial
- Safety Rated Not Safety Rated
- Lamp Type LED
- Flashlight Battery Size AA
- Flashlight Battery Type Lithium-Ion
- Rechargeable Yes
- Number of Batteries 1
- Batteries Included Yes
- Battery Burn Time 3.2/10 hr.
- Length 4.75"
- Body Dia. 0.73"
- Lumens 340/36
- Lumens Range 250 to 449
- Run Time on High Setting 3.2 hr.
- Maximum Lumens Output 340
- Lamp Life 25,000 hr.
- Body Color Silver
- Body Material Stainless Steel
- Switch Type Push Button
- Lens Material PMMA
- Safety Rating Not Rated
- Beam Distance 98/31m
- Impact Resistance Yes
- Light Output Modes High / Low
- Water Penetration Rating IPX4
- Standards ANSI/NEMA FL1
- Drop Rating 1m
- Peak Beam Intensity 896cd
- Manufacturers Warranty Length Limited Lifetime
Compliance and Restrictions
Hazardous material - General
Alternate Search Terms
LED Flashlights (851)
Customer Reviews
Product Reviews Disclaimer:
Grainger is neither responsible for, nor does it endorse, the content of any product review or statement posted. Any statements posted constitute the statements of the poster and are not the statements of Grainger. The statements posted by Grainger employees with the Grainger employee badge represent the views of such employees and are not the statements of Grainger. Grainger makes no representations as to the appropriateness, accuracy, completeness, correctness, currentness, suitability, or validity of any product review or statements posted, including those posted by employees with the Grainger employee badge, and is not liable for any losses, injuries or damages which may result from any such product review or statements. Use of any linked web site provided in a product review or post is at the user's own risk.


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Come giocare nei server hunger games per minecraft sp 1.5, - leggi | importante - server aggiornati alla 1.5.2 (presto 1.6.2) |guarda anche i server hunger games italiani (sphx) v 1.6.2| -http://www.you..com.Minecraft server list – 1.8.3 servers, Server name mc version; minecraft server 1 3.2 list added on feb, 2015. get to playing on this minecraft server 1 3.2 list type of game play. we currently have enough. Minecraft sp download | minecraftsp, Minecraft sp download is a modified version of the game minecraft. minecraft is today's leading sandbox computer game. minecraft's popularity has grown immensely.
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Schumacher CLC celebrates Plant Day at new garden
|Photos: Dale Dong
The garden is part of an effort by the American Heart Association and Summa Health System and will provide hands-on learning experiences rooted in offering nutritional choices.
Kindergartener QiMarah Campbell is pictured at right top as she takes a look at one of the new raised beds.
Shown at right bottom are Isaiah Welsh and Ja'Quan Hatten, both kindergarteners, who helped plant young herbs.
"We are thrilled to have been selected to receive an American Heart Association Teaching Garden and thankful for Summa Health System," said Schumacher CLC Principal Brandi Davis.
"This opportunity gives our children hands-on experience and an interactive nutrition curriculum that can help produce lifelong, heart-healthy habits."
Davis is pictured at top holding a plaque commemorating the opening of the Learning Garden as students look on.
— By Kathleen Folkerth
More Lawn & Garden
Calendar of Events
- TubaSummer - 7/24/2016
- Heathers The Musical - 7/24/2016
- Akron Symphony Orchestra - 7/24/2016
- Barbershop Harmony Spectacular - 7/24/2016
- Metro Parks Book Club: Silent Spring by Rachel Carson - 7/24/2016
...More Events


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Hyper Light Drifter will be available for PS4 and Xbox One next week
Nintendo releases alternate Splatoon covers to celebrate this weekend's Splatfest
Daily Scoop: July 19, 2016 - Anno franchise on sale at Steam
First NASCAR Heat: Evolution trailer gets the green light
Tumblestone Review: Puzzle Fans... Here's Your New Favorite Game
Uncharted 4: A Thief's End Review: Enjoying My Final Hurrah With Drake
Nintendo will publish an official NES history book this November
Daily Scoop: July 22, 2016 – More Pokemon shirts
Pokemon Go just set a record for first-week downloads on iOS App Store
Overwatch climbs to the top of the NPD's list of best-selling games for June 2016
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NHL 13 cover vote is down to Claude Giroux and Pekka Rinne
We've made it to the final round of voting for the NHL 13 cover athlete. After narrow victories in the semifinal round, Philadelphia Flyers forward Claude Giroux and Nashville Predators goalie Pekka Rinne have become the last men standing. Giroux defeated Pittsburgh Penguins forward Evgeni Malkin in the semifinal round, while Rinne iced New York Islanders forward John Tavares.
Final round voting begins today and will continue until June 4 at CoverVote.NHL.com.
The winner of the NHL 13 cover athlete vote will be revealed during this year's NHL Awards. The award show is scheduled for June 20 and will be televised on NBC Sports Network in the US and on CBC in hockey-mad Canada.
It's Dangerous To Go Alone! Read This.
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Want to donate to or volunteer for a Veterans charity or nonprofit? See ratings and reviews. Find top-rated veterans nonprofits and charities and start volunteering or donating today.
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Northern Jaguar Project
I am a free lance journalist, educator (University of New Mexico, Valencia Campus) and poet.I have been concerned for environmental issues for decades, but I claim no special expertise in that area. In... more
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Reel American Heroes Foundation
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Since the formation of the Army, Navy, and Marine Corps in 1775, honorable men and women have fought for the freedom, safety, and ideals of our country. Yet then and now, soldiers returning home have not always received the best treatment or opportunities despite their courageous military service.
Over the course of a year, nearly 130,000 veterans experience homelessness. An estimated 11-20% of Iraq and Afghanistan veterans will develop Post Traumatic Stress Disorder.
Fortunately, there are over 27,000 organizations supporting soldiers, veterans, and military families across the country. You can support our troops and veterans by packing care packages, volunteering at a local VA hospital, or working with a local veteran or military nonprofit.


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The Coranderrk Aboriginal reserve north-east of Melbourne has almost mythic status: a model farm, an enterprise and a community. The dream was freedom from government control and economic independence, to make Coranderrk and its community self-supporting. But the colonial authorities, the Aborigines' Protection Board and local squatters had other ideas.
This [series episode segment] has
extra audio,image,
In 1975, Gough Whitlam famously arrived in Gurindji country with the leasehold title and symbolically poured soil into Vincent Lingiari's hands. It also marked the end of a long, hard campaign by the Gurindji, who walked off Lord Vestey's cattle station in 1966 and went on strike for equal pay and the return of their land. Today some of the original strikers, who are also artists, take us along the trail they walked way back in 1966, as they prepare to paint the story ... and as they prepare to travel south to attend Kullum Whitlam's funeral.
This [series episode segment] has
Some of the original Gurdinji strikers take us along the trail they walked way back in 1966, as they prepare to paint the story and travel south to attend Kullum Whitlam's funeral.
The Coranderrk reserve north-east of Melbourne is steeped in history. 150 years ago the traditional owners of Melbourne met at the confluence of the Yarra River and Badger Creek. It would be their home for the next 60 years until the once-thriving farming community was closed and broken up. Their fight to save their country was epic - in evidence to official inquiries they argued strongly for self-determination and land rights.
Twenty years after the Mabo decision, the return of the Arabana's rights to their land highlights some of the complexities of native title.
After fighting their case for almost 15 years in the courts, the Arabana people have finally won their land back. The handback includes Lake Eyre - and as part of the agreement the Arabana are also now the leaseholders of the remote Finniss Springs pastoral station.
While the Letters Patent is a matter for South Australia, there's a move towards a referendum on constitutional recognition that affects us all.
Dr Irene Watson is a legal theorist from the Tanganekald and Meintangk peoples whose country spans the Coorong and the south-east of South Australia. She is currently associate professor of Aboriginal Studies at the David Unaipon College of Indigenous Education and Research within the University of South Australia.
Saturday 6pm
Repeated: Monday 9pm
Presented by Daniel Browning
The shocking abuse suffered by Aboriginal children in detention in the Northern Territory could be the tip of the iceberg. The editor of the Koori Mail, Rudi Maxwell broke the story that children had been tear-gassed in September last year and journalist Amy McQuire speculates on the reasons why we need to see abuse, in order to believe it.
Deborah Cheetham wrote Pecan Summer in the hope that it would bring operatic Aboriginal voices forward. "If you build it, they will come" she said at the time. Her gamble paid off.
Imagine if asylum-seekers were welcomed to our shores by an Aboriginal elder rather than security guards at a privately-run offshore detention centre. A production by Western Sydney's Powerhouse Youth Theatre, Tribunal establishes a people's court to decide what happens when we exercise human kindness instead of fear.
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Tim Vidra's Profile
VintageCrack specializes in handcrafted decor, vintage cameras and relics from days gone by — they just don't make them like they used to!
Let's keep in touch:
► Instagram: @VintageCrackFinds
► Blog: timvidraeats.com
For even more of my vintage finds, take a look around my other vintage Etsy shop, BehindTheScreenDoor.etsy.com which specializes in kitchen and culinary relics. Find handmade jewelry in my wife's Etsy shop: contrary.etsy.com.
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Crazy Substitute Teachers
Enjoy, NG4.03 / 5.00 809 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner3.98 / 5.00 2,134 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.93 / 5.00 1,954 Views
damn you
i was takin a big hit when this came on and i laughed to hard and didnt get my neccesary THC.
i couldnt stop laughing the whole time, i almost died just now.
twas alright
youll only laugh like this if your a light weight or are bearly starting to smoke \
the brok was the only amuzing part in this
lol if thats how you get when your stoned yew dont need no more XD
that was pretty funny- the guy sounded like a donkey
kinda tru
...at least its tru 4 noobs but once u've bin smokin up 4 awhile the laughin wears off
pretty funny though


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Big Ol' Fish - April 26
Submitted: 04/26/2013
Story By Newswatch 12 Sports
- It looks like Old Man Winter is finally taking a break until next winter. Some area catch and release anglers found plenty of luck.
Randy Robinson of Harshaw had plenty of action last week on the Peshtigo River. While fishing with a friend, Randy reeled in this 30" 11 pound walleye. he was using a husky jerk bait on a Rapala. It's the biggest one he's ever caught. After the picture, the fish was released.
Minocqua's Samanatha Gillich broke out a new fishing rod and reel in grand fashion. While fishing with her boyfriend, Samantha landed this 29inch walleye. It was caught on the Fox River in DePere. She was using a joined Shad Rap. This one was also released to fight another day.
And a blast from the past, take a look at the small mouth bass caught by Rhinelander's Brandon Michie. It was caught last fall on Oneida Lake in Harshaw. He was using a jig and rubber worm. After a quick photo op, it was back to the river for this catch.
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First annual mud run draws hundreds of participants
Submitted: 07/23/2016
Play Video
- The first annual Legionnaire Mud Challenge made its way to Crandon Saturday.
The International Off-Road Raceway welcomed nearly 200 participants ready to get down and dirty.
Men and women of all ages were brought together by the desire to work up a sweat.
"There's not a lot of opportunities like this in the northwoods, so it's always great to see one pop up," said Justin Lund.
He's an experienced obstacle course athlete and came in first in the men's 10k.
And for the women, Sheila Reynolds also took first place.
"It's fun and then you get other people running and you're encouraging them along in a way. It's just a great atmosphere," said Reynolds.
Athletes participating in the mud challenge had the option of running as an individual or on a team. When registering, they chose between the 5k or 10k.
Not only are these athletes getting all muddy as they're going through the race, they also have to climb over obstacles like these barrels of hay.
Some of the obstacles included a tire wall, slip n' slide, and muddy wet puddles to get through.
"I talked to a lot of the runners before we went and they said that the obstacles were tough and they really liked the course," said Beaver, one of four runners on a team.
Beaver and The Boys completed the course with only a few setbacks along the way.
"I lost my shoe in the middle of it and had to go back and find it," he said.
Athletes had to get up and over more than 15 obstacles throughout the race.
All the money raised will go to the Northwoods United Way and American Cancer Society.
The second annual Legionnaire Mud Challenge will take place next year.
+ Read More
Crow tests positive for West Nile virus in Langlade County
Submitted: 07/22/2016
- A dead crow found in Langlade County last week tested positive for West Nile virus. It's the first crow to test positive in Langlade County since surveillance started for the virus on May 1.
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Former Gov. Thompson sees Trump as winner, Cruz as loser at Republican convention
Submitted: 07/22/2016
- Former Wisconsin Gov. Tommy Thompson sees Donald Trump as the big winner at the recently completed Republican National Convention, while Texas Sen. Ted Cruz is the biggest loser.
Thompson spoke to The Associated Press on Friday after attending his 11th national convention. He's been to every one since 1976.
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Strategic tree planting, cutting in Upper Peninsula could help suffering deer population rebound
Submitted: 07/22/2016
Play Video
- Hunters, biologists, and wildlife watchers worry about the low deer population in northern Wisconsin.
But in Michigan's Upper Peninsula, the situation is even worse.
Wildlife biologists say nearly every single fawn died after the harsh winters of 2012 and 2013, further hurting a struggling herd. In fact, the population has been on the decline since 1995.
+ Read More
Officer Mark Raddatz sworn in as newest member of Rhinelander Police Department
Submitted: 07/22/2016
Play Video
- Emergency responders save lives and build trust in the community.
And now the Rhinelander Police Department has a new member of that team after swearing in a new officer Friday morning.
+ Read More
Gov. Walker appoints Kelly to Wisconsin Supreme Court
Submitted: 07/22/2016
- Gov. Scott Walker has appointed attorney Dan Kelly to the Wisconsin Supreme Court.
Walker's spokesman Tom Everson told The Associated Press on Friday that the governor had decided to name Kelly to the seven-member court.
Kelly will replace retiring Justice David Prosser. His appointment won't change the court's 5-2 conservative majority, however.
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Do you know the last time Rhinelander hit 90 degrees?
Submitted: 07/22/2016
Play Video
- We finally did it. We hit 90 degrees Thursday, July 21st, for the first time in almost three years.
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Molecular and cellular neurosciences [journal]
2877 results
- Anti-amyloidogenic effects of glycosphingolipid synthesis inhibitors occur independently of ganglioside alterations. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jul 1.:63-70.
- AbstractPublisher Full Text
Evidence has suggested that ganglioside abnormalities may be linked to the proteolytic processing of amyloid precursor protein (APP) in Alzheimer's disease (AD) and that pharmacological inhibition of ganglioside synthesis may reduce amyloid β-peptide (Aβ) production. In this study, we assessed the usefulness of two well-established glycosphingolipid (GSL) synthesis inhibitors, the synthetic ceramide analog D-PDMP (1-phenyl 2-decanoylamino-3-morpholino-1-propanol) and the iminosugar N-butyldeoxynojirimycin (NB-DNJ or miglustat), as anti-amyloidogenic drugs in a human cellular model of AD. We found that both GSL inhibitors were able to markedly inhibit Aβ production, although affecting differently the APP cleavage. Surprisingly, the L-enantiomer of PDMP, which promotes ganglioside accumulation, acted similarly to D-PDMP to inhibit Aβ production. Concurrently, both D- and L-PDMP strongly and equally reduced the levels of long-chain ceramides. Altogether, our data suggested that the anti-amyloidogenic effects of PDMP agents are independent of the altered cellular ganglioside composition, but may result, at least in part, from their ability to reduce ceramide levels. Moreover, our current study established for the first time that NB-DNJ, a drug already used as a therapeutic for Gaucher disease (a lysosomal storage disorder), was also able to reduce Aβ production in our cellular model. Therefore, our study provides novel information regarding the possibilities to target amyloidogenic processing of APP through modulation of sphingolipid metabolism and emphasizes the potential of the iminosugar NB-DNJ as a disease modifying therapy for AD.
- An electrophysiological study on the effects of BDNF and FGF2 on voltage dependent Ca(2+) currents in developing human striatal primordium. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 28.:50-62.
- AbstractPublisher Full Text
Over the past decades, studies in both Huntington's disease animal models and pilot clinical trials have demonstrated that replacement of degenerated striatum and repair of circuitries by grafting fetal striatal primordium is feasible, safe and may counteract disease progression. However, a better comprehension of striatal ontogenesis is required to assess the fetal graft regenerative potential. During neuronal development, neurotrophins exert pleiotropic actions in regulating cell fate and synaptic plasticity. In this regard, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 2 (FGF2) are crucially implicated in the control of fate choice of striatal progenitor cells. In this study, we intended to refine the functional features of human striatal precursor (HSP) cells isolated from ganglionic eminence of 9-12week old human fetuses, by studying with electrophysiological methods the effect of BDNF and FGF2 on the membrane biophysical properties and the voltage-dependent Ca(2+) currents. These features are particularly relevant to evaluate neuronal cell functioning and can be considered reliable markers of the developmental phenotype of human striatal primordium. Our results have demonstrated that BDNF and FGF2 induced membrane hyperpolarization, increased the membrane capacitance and reduced the resting total and specific conductance values, suggesting a more efficient control of resting ionic fluxes. Moreover, the treatment with both neurotrophins enhanced N-type Ca(2+) current amplitude and reduced L- and T-type ones. Overall, our data indicate that BDNF and FGF2 may help HSP cells to attain a more functionally mature phenotype.
- Expression of 14-3-3 transcript isoforms in response to ethanol exposure and their regulation by miRNAs. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 28.:44-49.
- AbstractPublisher Full Text
The 14-3-3 proteins are a family of highly conserved molecular chaperones involved in the regulation of a number of key cellular functions including metabolism, stress response, protein trafficking, cell-cycle control, signal transduction, transcription, apoptosis and neurotransmission. 14-3-3 proteins have also been implicated in the pathophysiology of neurodegenerative disorders including Alzheimer disease and Parkinson disease. Recent studies have also shown that 14-3-3s are differentially expressed in the frontal cortex of human alcoholics suggesting a potential role in the pathophysiology of alcohol use disorders. Here we measured the expression of 14-3-3 transcripts in HEK293T cells in response to chronic ethanol treatment. Five of the seven transcripts (14-3-3β, 14-3-3γ, 14-3-3ζ, 14-3-3ε and 14-3-3θ) were significantly down-regulated following chronic exposure to ethanol for a five day period with these changes persisting even after withdrawal from ethanol treatment. One transcript, 14-3-3σ, was significantly up-regulated following chronic ethanol exposure and 14-3-3η showed no differences in expression in the same treatment model. The pattern of expression changes is similar to those seen in the frontal cortex of human alcoholics. To investigate the role of miRNAs in mediating the expression changes we measured the expression of the 14-3-3 transcripts following transfection with miR-203, miR-144 and miR-7 mimics. Although these miRNAs had predicted target sites in the 3'untranslated region of each 14-3-3 isoform, only miR-203 resulted in a down-regulation of 14-3-3θ transcript. In addition, the expression of 14-3-3γ was upregulated following transfection with miR-7 and miR-144 mimics. MiRNA regulation of these isoforms following alcohol exposure may lead to alterations in neurotransmission, the balance between cell survival and cell death, as well as changing the rewarding effects of alcohol.
- LRRK2 interferes with aggresome formation for autophagic clearance. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 28.:71-80.
- AbstractPublisher Full Text
Autosomal-dominant mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) account for the most common monogenic form of Parkinson's disease (PD). A link between autophagy dysregulation and LRRK2 has consistently been reported, but it remains poorly defined which step is targeted by LRRK2. Here, we sought to examine the effect of LRRK2 on the sequestration and degradation of aggregated protein complexes for autophagic clearance. Because two major intracellular protein degradation systems, the ubiquitin proteasome system and the autophagy, are functionally coupled, proteasome inhibition is suggested to activate autophagy. So, we induced protein quality control-associated autophagy using the proteasome inhibitor MG132 in differentiated SH-SY5Y cells and mice expressing G2019S mutant LRRK2 to uncover how the autophagy pathway is affected by LRRK2. We found that LRRK2 disrupted aggresome formation for autophagic clearance of accumulated protein aggregates. Specifically, we observed the following in differentiated SH-SY5Y cells with overexpressed wild-type and G2019S LRRK2: 1) large, clear, perinuclear aggresomes were not detected under MG132, instead, much smaller aggregates were broadly distributed in the cytosol; 2) enhanced accumulation of LC3-II and p62/ubiquitin-positive protein inclusions were noted; and 3) protein aggregates were not cleared even after a recovery period, which exacerbated the MG132-induced cytotoxicity. Notably, higher protein accumulation was detected in the brains of G2019S transgenic mice than in the brains of littermate control mice under proteasome inhibition. Our present findings provide insight into the precise mechanisms that underlie autophagy dysregulation in the brains of patients with PD with LRRK2 mutations.
- MicroRNA-1-associated effects of neuron-specific brain-derived neurotrophic factor gene deletion in dorsal root ganglia. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 21.:36-43.
- AbstractPublisher Full Text
MicroRNAs (miRNAs) regulate gene expression in physiological as well as in pathological processes, including chronic pain. Whether deletion of a gene can affect expression of the miRNAs that associate with the deleted gene mRNA remains elusive. We investigated the effects of brain-derived neurotrophic factor (Bdnf) gene deletion on the expression of miR-1 in dorsal root ganglion (DRG) neurons and its pain-associated downstream targets heat shock protein 60 (Hsp60) and connexin 43 (Cx43) in tamoxifen-inducible conditional knockout mice, Bdnf(fl/fl); Advillin-CreER(T2) (Bdnf cKO).Efficient Bdnf gene deletion was confirmed in DRG of Bdnf cKO mice by Real-Time qRT-PCR and ELISA 10days after completed tamoxifen treatment. In DRG, miR-1 expression was reduced 0.44-fold (p<0.05; Real-time qRT-PCR) in Bdnf cKO compared to floxed wildtype littermate control Bdnf(fl/fl) mice (WT). While Hsp60 protein expression was increased 1.85-fold (p<0.05; Western blot analysis), expression levels of Cx43 and the miR-1-associated transcription factors MEF2a and SRF remained unchanged. When analyzing Bdnf cKO mice 32days after complete tamoxifen treatment to investigate whether observed expression alterations remain permanently, we found no significant differences between Bdnf cKO and WT mice. However, miRNA microarray analysis revealed that 167 miRNAs altered (p<0.05) in DRG of these mice following Bdnf gene deletion.Our results indicate that deletion of Bdnf in DRG neurons leads to a temporary dysregulation of miR-1, suggesting an impairment of a presumable feedback loop between BDNF protein and its targeting miR-1. This appears to affect its downstream protein Hsp60 and as a consequence might influence the phenotype after inducible Bdnf gene deletion. While this appears to be a MEF2a-/SRF-independent and transient effect, expression levels of various other miRNAs may remain permanently altered.
- Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 23.:27-35.
- AbstractPublisher Full Text
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction, limited verbal communication and repetitive behaviors. Recent studies have demonstrated that Wnt signaling and mTOR signaling play important roles in the pathogenesis of ASD. However, the relationship of these two signaling pathways in ASD remains unclear.We assessed this question using the valproic acid (VPA) rat model of autism. Our results demonstrated that VPA exposure activated mTOR signaling and suppressed autophagy in the prefrontal cortex, hippocampus and cerebellum of autistic model rats, characterized by enhanced phospho-mTOR and phospho-S6 and decreased Beclin1, Atg5, Atg10, LC3-II and autophagosome formation. Rapamycin treatment suppressed the effect of VPA on mTOR signaling and ameliorated the autistic-like behaviors of rats in our autism model. The administration of VPA also activated Wnt signaling through up-regulating beta-catenin and phospho-GSK3beta. Suppression of the Wnt pathway by sulindac relieved autistic-like behaviors and attenuated VPA-induced mTOR signaling activation in autistic model rats.Our results demonstrate that VPA exposure sequentially activates Wnt signaling and mTOR signaling in rats. Suppression of the Wnt signaling pathway relieves autistic-like behaviors partially by deactivating the mTOR signaling pathway in VPA-exposed rats.
- Linckosides enhance proliferation and induce morphological changes in human olfactory ensheathing cells. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 22.:1-13.
- AbstractPublisher Full Text
Linckosides are members of the steroid glycoside family isolated from the starfish Linckia laevigata. These natural compounds have notable neuritogenic activity and synergistic effects on NGF-induced neuronal differentiation of PC12 cells. Neurogenic factors or molecules that are able to mimic their activities are known to be involved in the survival, proliferation and migration of neurons and glial cells; however how glial cells respond to specific neurogenic molecules such as linckosides has not been investigated. This study aimed to examine the effect of three different linckosides (linckoside A, B and granulatoside A) on the morphological properties, proliferation and migration of human olfactory ensheathing cells (hOECs). The proliferation rate after all the treatments was higher than control as detected by MTS assay. Additionally, hOECs displayed dramatic morphological changes characterized by a higher number of processes after linckoside treatment. Interestingly changes in microtubule organization and expression levels of some early neuronal markers (GAP43 and βIII-tubulin) were also observed. An increase in the phosphorylation of ERK 1/2 after addition of the compounds suggests that this pathway may be involved in the linckoside-mediated effects particularly those related to morphological changes. These results are the first description of the stimulating effects of linckosides on hOECs and raise the potential for this natural compound or its derivatives to be used to regulate and enhance the therapeutic properties of OECs, particularly for cell transplantation therapies.
- The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis. [JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 11.:14-26.
- AbstractPublisher Full Text
Dendritic spines are fine neuronal processes where spatially restricted input can induce activity-dependent changes in one spine, while leaving neighboring spines unmodified. Morphological spine plasticity is critical for synaptic transmission and is thought to underlie processes like learning and memory. Significantly, defects in dendritic spine stability and morphology are common pathogenic features found in several neurodevelopmental and neuropsychiatric disorders. The remodeling of spines relies on proteins that modulate the underlying cytoskeleton, which is primarily composed of filamentous (F)-actin. The Rho-GTPase Rac1 is a major regulator of F-actin and is essential for the development and plasticity of dendrites and spines. However, the key molecules and mechanisms that regulate Rac1-dependent pathways at spines and synapses are not well understood. We have identified the Rac1-GTPase activating protein, α2-chimaerin, as a critical negative regulator of Rac1 in hippocampal neurons. The loss of α2-chimaerin significantly increases the levels of active Rac1 and induces the formation of aberrant polymorphic dendritic spines. Further, disruption of α2-chimaerin signaling simplifies dendritic arbor complexity and increases the presence of dendritic spines that appear poly-innervated. Our data suggests that α2-chimaerin serves as a "brake" to constrain Rac1-dependent signaling to ensure that the mature morphology of spines is maintained in response to network activity.
- High-throughput screening in the C. elegans nervous system. [REVIEW, JOURNAL ARTICLE]
- Mol Cell Neurosci 2016 Jun 3.
- AbstractPublisher Full Text
The nematode Caenorhabditis elegans is widely used as a model organism in the field of neurobiology. The wiring of the C. elegans nervous system has been entirely mapped, and the animal's optical transparency allows for in vivo observation of neuronal activity. The nematode is also small in size, self-fertilizing, and inexpensive to cultivate and maintain, greatly lending to its utility as a whole-animal model for high-throughput screening (HTS) in the nervous system. However, the use of this organism in large-scale screens presents unique technical challenges, including reversible immobilization of the animal, parallel single-animal culture and containment, automation of laser surgery, and high-throughput image acquisition and phenotyping. These obstacles require significant modification of existing techniques and the creation of new C. elegans-based HTS platforms. In this review, we outline these challenges in detail and survey the novel technologies and methods that have been developed to address them.
- Polysialic acid enters the cell nucleus attached to a fragment of the neural cell adhesion molecule NCAM to regulate the circadian rhythm in mouse brain. [Journal Article]
- Mol Cell Neurosci 2016 Jul.:114-27.
- AbstractPublisher Full Text
In the mammalian nervous system, the neural cell adhesion molecule NCAM is the major carrier of the glycan polymer polysialic acid (PSA) which confers important functions to NCAM's protein backbone. PSA attached to NCAM contributes not only to cell migration, neuritogenesis, synaptic plasticity, and behavior, but also to regulation of the circadian rhythm by yet unknown molecular mechanisms. Here, we show that a PSA-carrying transmembrane NCAM fragment enters the nucleus after stimulation of cultured neurons with surrogate NCAM ligands, a phenomenon that depends on the circadian rhythm. Enhanced nuclear import of the PSA-carrying NCAM fragment is associated with altered expression of clock-related genes, as shown by analysis of cultured neuronal cells deprived of PSA by specific enzymatic removal. In vivo, levels of nuclear PSA in different mouse brain regions depend on the circadian rhythm and clock-related gene expression in suprachiasmatic nucleus and cerebellum is affected by the presence of PSA-carrying NCAM in the cell nucleus. Our conceptually novel observations reveal that PSA attached to a transmembrane proteolytic NCAM fragment containing part of the extracellular domain enters the cell nucleus, where PSA-carrying NCAM contributes to the regulation of clock-related gene expression and of the circadian rhythm.


text:
Chrome quickly skyrocketed from a Google pet project to the most popular browser in the world. Here are some of our most popular Chrome extensions and guides from Lifehacker in 2014.
|Scooped by kathymcdonough
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ManufacturingStories's curator insight, September 18, 2014 10:42 AM
For more resources on STEM Education visit http://bit.ly/1640Tbl
Norton Gusky's curator insight, July 20, 2014 7:33 AM
Good examples with personal stories including Padlet, Today's Meeting, and Socrative.
Sandra Carswell's curator insight, July 20, 2014 9:58 AM
Backchannel tools can be used before, during, and after lessons, giving all students a voice in the conversation/discussion. Brainstorming, questioning, sharing ideas and resources.
Darleana McHenry's curator insight, July 20, 2014 8:03 PM
I like the idea of children expressing themselves and using technology to tell a story.
SLS Guernsey's curator insight, August 11, 2014 8:05 AM
A good list to get you started on Chromebook.
Gary Harwell's curator insight, July 26, 2014 11:04 AM
Are our students able to use these apps to make class videos?


text:
The Mickey Mouse's Exfactor Canoes attraction at a distance
These Indian-made canoes have a water's-eye view of the ripples around the Rivers of the Plaza. It's the most labor-intensive way to get away from the lazy people in your party without having much time to do anything but row!
We suggest you don't try Princess Mode
© copyright 2011–2016
A Pants Aflame production


text:
|By Mark Tapscott; Mark Tapscott, Executive Editor
|Proquest LLC
As the Washington Examiner's editorial page predicted
The do-over demand became inevitable when the
The German car company had done everything it could to assist the UAW's effort and right up to the last moment before workers started casting ballots, even opponents of union expected the first unionized foreign auto plant in the South would be approved.
A novel concept
In its objection, UAW officials charged that "'a coordinated and widely-publicized coercive campaign' to deprive 'workers of their federally-protected right' to 'support and select the UAW as their exclusive representative,'" according to the Journal.
The union was especially upset by Sen.
A perfect laboratory
Even so, there are NLRB precedents, beginning in the 1948 General Shoe case, in which the labor board has held that a representation election must occur in as nearly laboratory perfect conditions as possible to insure the undiluted will of the workers is expressed.
But, as the Journal points out, it's difficult to conceive of a more perfect laboratory for the UAW to win such an election:
"If anything,
Prediction: The NLRB will grant the do-over and the UAW will lose the second vote by an even larger margin than it did the first.
On today's washingtonexaminer.com
Monday Editorial:
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Beltway Confidential/
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National Review Online: There's a new
The Weekly Standard: Obama's fantasy-based foreign policy.
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The Federalist: Limited government in an age of militant progressivism.
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UTNE Reader: Why the bright millennials are staying home.
Blog Right
Gateway Pundit: Remember when Obama pushed
Jammie Wearing Fools: Shady Farrakhan "charity" received
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Health/Employee Benefits
- When Big Insurance Companies Merge, Who Benefits?
- Loss Of Employer-Based Health Insurance Hurts Early Retirees
- Aflac CEO 'Pleased' With 2Q Results
- Blue Cross Retreat In Minnesota Prompts Competitors To Reconsider Premiums
- Surprise Medical Bills: The Struggle Continues
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Question about purchasing a UPS
Last response: in Components
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text:
Crazy Substitute Teachers
Enjoy, NG4.03 / 5.00 2,647 Views
Vacuum Salesman
This dude and his Megazord vacuum cleaner4.01 / 5.00 2,909 Views
Markiplier Animated | Mark Of The Survey Corps
This took far too long to make...3.96 / 5.00 7,568 Views
Lawlsome sauce
This was an amazing video
Well done, kept loling
This is funny all in all.
This is also annoying of all that talking which also ruins Ryu and Akuma's staring contest....
This doesn't explain anything at all....
but i guess why this is a comedy animation.
she soooooooooooo cute
I don't think I know
I have seen all of the MvC 3 videos and this is by far the best, I knew that since you did it that it would have excellent art work and good voice overs but, My Gawd this is awesome Awesome face approved.
That's still funny to watch. I love your style and this voiceacting is priceless. Keep that uppy


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It's National Nestbox week. Spring is in the air, and the RSPB are offering 10% off all nestboxes until 21st Feb, in celebration of National Nestbox Week. Visit the RSPB website here
become anEkklesia Partner
Select the newsletter(s) to which you want to subscribe or unsubscribe.
The TUC has published a new report outlining how the UK can undergo a clean energy transition to create high-quality jobs and secure a major share...
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Tweets by @Ekklesia_co_uk


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© American Cancer Society
Volume 85, Issue 3
Pages 517–756
Alan D. Langerak and Harinder S. Garewal
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<517::AID-CNCR1>3.0.CO;2-K
Although transforming growth factor-β1 may prove to be an important new tumor marker in colorectal carcinoma, larger, prospective studies are needed to confirm this theory.
See referenced original article on pages 554-61.
Carlos Torres, Jerrold R. Turner, Helen H. Wang, William Richards, David Sugarbaker, Ali Shahsafaei and Robert D. Odze
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<520::AID-CNCR2>3.0.CO;2-L
A retrospective study of morphologic prognostic features in 96 cases of resected Barrett's-associated adenocarcinoma, either with (61 cases) or without (35 cases) preoperative neoadjuvant chemoradiotherapy, found that older patient age, higher pathologic stage, absence of peritumoral lymphoid infiltrate, and most likely perineural invasion were associated with shortened survival by multivariate analysis. The effect of chemoradiotherapy, as assessed by the degree of residual tumor, did not correlate with survival in this patient group.
Shigeru Fujimoto, Makoto Takahashi, Takaaki Mutou, Kokuriki Kobayashi and Tadashi Toyosawa
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<529::AID-CNCR3>3.0.CO;2-9
Seventy-one gastric carcinoma patients with serosal invasion were treated with intraperitoneal hyperthermic chemoperfusion combined with surgery. The survival rate of these 71 patients was significantly higher than that of the control group of 70 patients who were treated with surgery alone.
Giuseppe Colucci, Evaristo Maiello, Vittorio Gebbia, Francesco Giuliani, Giuseppe Serravezza, Giorgio Lelli, Silvana Leo, Gianfranco Filippelli, Giampaolo Nicolella and Mario Brandi
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<535::AID-CNCR4>3.0.CO;2-7
A Phase III trial was performed to evaluate the impact of interferon on the efficacy of levofolinic acid and 5-fluorouracil against metastatic colorectal carcinoma, as well as the role of tumor burden and liver involvement as prognostic factors. Interferon did not appear to have a positive influence on patient outcome, although liver involvement and tumor burden were found to be important prognostic factors.
Jong Hun Kim, Min Jeong Kang, Chul Uhng Park, Hee Jin Kwak, Yong Hwang and Gou Young Koh
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<546::AID-CNCR5>3.0.CO;2-0
The results of this study indicate that significant activation of CDK2 and cdc2 occurs in primary colorectal carcinoma.
Kang Sup Shim, Kwang Ho Kim, Woon Sup Han and Eung Bum Park
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<554::AID-CNCR6>3.0.CO;2-X
Serum levels of transforming growth factor-β1 (TGF-β1) in patients with colorectal carcinoma were significantly higher than those in normal control subjects and these levels decreased significantly after curative surgical resection. These results suggest that the serum level of TGF-β1 might be a useful biomarker in the management of colorectal carcinoma. See also pages 517–9.
Hala R. Makhlouf, Kamal G. Ishak and Zachary D. Goodman
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<562::AID-CNCR7>3.0.CO;2-T
To the authors' knowledge, this series of 137 cases is the largest series reported from one institution. Epithelioid hemangioendothelioma is of unknown etiology and only one histologic parameter, tumor cellularity, is predictive of outcome.
Masato Kayahara, Takukazu Nagakawa, Tetsuo Ohta, Hirohisa Kitagawa, Keiichi Ueno, Hidehiro Tajima, Ayman Elnemr and Koichi Miwa
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<583::AID-CNCR8>3.0.CO;2-J
Paraaortic lymph node involvement in invasive ductal carcinoma of the pancreas is common and highly significant for prognosis. Therefore the resected specimen should include the paraaortic lymph nodes.
Martin C. Jäckel, Mansur A. Dorudian, Dagmar Marx, Ulrich Brinck, Alfred Schauer and Wolfgang Steiner
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<591::AID-CNCR9>3.0.CO;2-F
In this study, the rate of spontaneous apoptosis occurring in laryngeal carcinoma was closely associated with mitotic activity but appeared to be unrelated to protein expression of bcl-2 and bax. Elevated bcl-2 and reduced bax levels were correlated with adverse prognostic parameters.
Naoyoshi Onuki, Ignacio I. Wistuba, William D. Travis, Arvind K. Virmani, Kazuo Yashima, Elizabeth Brambilla, Phillip Hasleton and Adi F. Gazdar
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<600::AID-CNCR10>3.0.CO;2-W
The authors studied the molecular changes present in 59 cases representing all 4 types of pulmonary neuroendocrine tumors. Their findings support the clinicopathologic concept that neuroendocrine tumors of the lung represent a spectrum ranging from low grade typical carcinoids to highly malignant neuroendocrine carcinomas.
Yener Koc, Kenneth B. Miller, David P. Schenkein, Philip Daoust, Kellie Sprague and Eugene Berkman
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<608::AID-CNCR11>3.0.CO;2-5
Solitary extramedullary myeloid sarcoma as a pattern of recurrence following allogeneic bone marrow transplantation in patients with acute or chronic myeloid leukemia is rare. The prognosis for this group of patients is very poor, as in any case of posttransplantation leukemic relapse, with the exception of patients with chronic myeloid leukemia.
John Boyages M.B.B.S., Geoff Delaney M.B.B.S. and Richard Taylor M.B.B.S.
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<616::AID-CNCR12>3.0.CO;2-7
Patient tumor and treatment factors as potential predictors for local recurrence after surgery for ductal carcinoma in situ are reviewed. This meta-analysis shows that various pathologic factors and conservative surgery alone are predictors for higher incidence of local recurrence.
Paul E. Goss, Caroline Reid, Melania Pintilie, Ruth Lim and Naomi Miller
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<629::AID-CNCR13>3.0.CO;2-V
This single-institution review of 229 male breast carcinoma patients who presented during the years 1955–1996 describes clinical presentation, some changes in treatment practices, and no improvement in outcome over the 4-decade period. Collection of detailed, prospective data on male breast carcinoma patients may optimize clinical management.
Sanne B. Schagen, Frits S. A. M. van Dam, Martin J. Muller, Willem Boogerd, Jaap Lindeboom and Peter F. Bruning
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<640::AID-CNCR14>3.0.CO;2-G
Breast carcinoma patients treated with adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) chemotherapy have a significantly higher risk of late cognitive impairment than breast carcinoma patients not treated with chemotherapy. This cognitive impairment is unaffected by anxiety, depression, fatigue, and time since treatment, and is not related to patients' reports of cognitive dysfunction.
Wen-Fang Cheng, Chien-Nan Lee, Jan-Show Chu, Chi-An Chen, Tzer-Ming Chen, Wen-Yi Shau, Chang-Yao Hsieh and Fon-Jou Hsieh
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<651::AID-CNCR15>3.0.CO;2-9
In vivo vascularity index was found to correlate well with in vitro microvessel density. The authors believe the in vivo vascularity index would help to predict lymph node metastasis in patients with cervical carcinoma.
Robert E. Bristow, Rae Lynn Baldwin, S. Diane Yamada, Murray Korc and Beth Y. Karlan
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<658::AID-CNCR16>3.0.CO;2-M
Enhanced expression of transforming growth factor-β (TGF-β)1 and TGF-β3 mRNA, as well as loss of expression of TGF-β receptors TβR-I and TβR-III, were observed in ovarian carcinoma specimens, suggesting a role for alterations in TGF-β-mediated pathways in ovarian tumorigenesis.
Motohiko Shimizu, Toshio Nikaido, Toshihiko Toki, Tanri Shiozawa and Shingo Fujii
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<669::AID-CNCR17>3.0.CO;2-F
Clear cell carcinoma exhibits higher expression of cyclin E and p21 and lower expression of p53 and cyclin A than any other histologic subtype of ovarian adenocarcinoma.
Per Fransson and Anders Widmark
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<678::AID-CNCR18>3.0.CO;2-E
Changes in complications between 4 and 8 years after radiotherapy were prospectively assessed among prostate carcinoma patients who received a self-assessment questionnaire, and these changes were compared with those found in an age-matched population.
Toshiaki Kinouchi, Shigeru Saiki, Norio Meguro, Osamu Maeda, Masao Kuroda, Michiyuki Usami and Toshihiko Kotake
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<689::AID-CNCR19>3.0.CO;2-7
The tumor size cutoff of 5.5 cm, rather than 7.0 cm, in the TNM system (fifth edition, 1997) for classifying renal cell carcinoma was most significantly predictive of the survival of Robson Stage I patients after radical nephrectomy. The tumor size cutoff of 5.5 cm was also shown to be significant in univariate and multivariate analyses.
Rena Vassilopoulou-Sellin, Lynn Palmer, Sarah Taylor and Catherine S. Cooksley
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<696::AID-CNCR20>3.0.CO;2-4
Breast carcinoma developing after thyroid carcinoma was diagnosed more frequently than expected in young adult women. This potential association and plausible mechanisms should be evaluated in larger cohorts of patients.
Wilbur B. Bowne, Jonathan J. Lewis, Daniel A. Filippa, Ruben Niesvizky, Ari D. Brooks, Michael E. Burt and Murray F. Brennan
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<706::AID-CNCR21>3.0.CO;2-7
The authors report on the responses to therapy and clinical outcomes of patients with the clinical and histopathologic features of unicentric and multicentric Castleman's disease treated at a single institution. The current understanding of the pathogenesis of this disease in regard to possible treatment strategies is discussed.
Po-Min Chen, Tzeon-Jye Chiou, Ruey-Kuen Hsieh, Frank S. Fan, Chiau-Jun Chu, Ching-Zong Lin, Hung Chiang, Chueh-Chuan Yen, Wei-Shu Wang and Jin-Hwang Liu
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<718::AID-CNCR22>3.0.CO;2-Y
Point mutations and rearrangements of the p53 gene were found in 9 (10.8%) of 84 non-Hodgkin's lymphomas. Patients who carried these alterations had worse outcomes than other patients. Of three patients with gene rearrangements, the two with one abnormal p53 allele had a more favorable prognosis than the one with two abnormal alleles.
Rick Ahmad, Brian R. Mayol, Mary Davis and Bruce T. Rougraff
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<725::AID-CNCR23>3.0.CO;2-2
Combination therapy with chemotherapy, radiation, and attempted surgical resection of the tumor mass in patients younger than 16 years with extraskeletal Ewing's sarcoma was associated with a better survival than that for older patients or those treated without surgical resection.
Päivi M. Lähteenmäki, Heikki A. Salmi, Toivo T. Salmi, Hans Helenius, Anne Mäkipernaa, Marjatta Lanning, Mikko Perkkiö and Martti A. Siimes
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<732::AID-CNCR24>3.0.CO;2-7
Childhood cancer survivors are less likely to meet the requirements for military service in Finland, but enlisted survivors cope with the service well if their treatment sequelae are evaluated carefully at the time of military enlistment. The survivors who are eligible for duty are well motivated for training and use the medical services of the garrison physician less than controls, and, as a whole, their service is comparable to that of the general population.
Anirban Maitra, Kazuo Yashima, Asha Rathi, Charles F. Timmons, Beverly Barton Rogers, Jerry W. Shay and Adi F. Gazdar
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<741::AID-CNCR25>3.0.CO;2-6
Neuroblastic tumors are characterized by unpredictable biologic behavior. In this study, the expression of the RNA component of human telomerase (hTR) was examined in archival material from neuroblastic tumors by an in situ hybridization assay, and hTR expression was correlated with prognosis and outcome of therapy.
Nicholas C. Saenz, Judit Saenz-Badillos, Klaus Busam, Michael P. LaQuaglia, Martin Corbally and Mary S. Brady
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<750::AID-CNCR26>3.0.CO;2-5
Like adults, children with melanoma are at significant risk of dying of the disease. The survival of children is similar to that of adults and is related to stage at presentation. The survival advantage observed for adult females is not seen among children.
Ikram A. Burney, Tariq Siddiqui and Imran Siddiqui
Version of Record online: 19 NOV 2000 | DOI: 10.1002/(SICI)1097-0142(19990201)85:3<755::AID-CNCR27>3.0.CO;2-O