text:
|Publication number
|Publication type
|Application number
|Publication date
|Mar 10, 1992
|Filing date
|Jul 24, 1990
|Priority date
|Sep 14, 1987
|Fee status
|Publication number
|Takao Umeda, Tetsuya Nagata, Tatsuo Igawa
|Original Assignee
|Hitachi, Ltd.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (8), Referenced by (17), Classifications (11), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation of application Ser. No. 244,064, filed Sept. 14, 1988, now abandoned.
This invention relates to an apparatus and method for driving an optical printer having at least one liquid crystal optical switch using a ferroelectric liquid crystal and which enables obtaining a high contrast.
In a conventional method of driving a ferroelectric liquid crystal optical switch array disclosed in U.S. Pat. No. 4,508,429, U.S. Pat. No. 4,591,886, U.S. Pat. No. 4,712,876 and U.S. Pat. No. 4,655,561, one frame term TL consists of a writing period TW for determining the light transmission state and a retention period TH (non-selection period in a time sharing driving operation) as shown in FIG. 2a. It takes about 0.1-0.5 ms for the liquid crystal molecules to respond to the applied voltage signal. Accordingly, the light transmission waveforms in ON state and OFF state in one frame term become as shown in FIG. 2b. The light transmission waveform OFF(A) represents a change of a light transmitting term into a light interrupting term, the light transmission waveform OFF(B) represents a change of a light interrupting term into a light interrupting one, the waveform ON(A) represents a change of a light interrupting term into a light transmitting term, and the light transmission waveform ON(B) represents a change of a light term into a light transmitting term. Thus, these light transmission waveforms have two kinds of waveforms, the light transmission states (ON) and light interrupting state (OFF) having different light transmission amounts (which are proportional to the areas of the hatched portions of FIG. 2b) respectively in one frame term. Out of these periods, the period ON(B) has a maximum light transmission amount. In the OFF periods, the light transmission amount of the period OFF(A) becomes higher. Consequently, the contrast ratio, i.e. the value of (light transmission amount in the ON periods) / (light transmission amount in the OFF periods) is not uniform. The contrast ratio is improved by reducing the light transmission amount in the period OFF(A). In this method, if the last period of one frame term is always put in the light interrupting state, the initial light transmission in the period OFF(A) can be eliminated.
The present inventors proposed a similar operation in U.S. Pat. No. 4,746,196 entitled "Multiplexed driving method for an optical switching element employing ferroelectric liquid crystal".
A time sharing driving method for a ferroelectric liquid crystal display panel, which has a writing reset period and a period in which the light transmission state of the reset is retained or reversed to select light transmitting state, is known (Japanese Patent Laid-Open No. 56937/1987). FIG. 3 shows the voltages at the scanning electrodes, the voltage at the signal electrodes and a voltage representing a difference between these two voltages, that is to say, which is an applied voltage to a liquid crystal layer, and a waveform of the relative transmitted light in this driving method. In a reset period 2 TL /N (wherein N is the number of time division; and TL is one frame term), a reset voltage signal Vreset for obtaining a reset state (light interrupting state) is applied. This voltage signal consists of a combination of a pair of voltage pulses, i.e. +V0 /2 (portion A) in the first half TL /N of the reset period and -V0 (portion B) in the latter half TL /(2N) so that an average voltage in the reset period become substantially zero. Owing to this reset period, the contrast can be improved. Unless an average voltage in the reset period becomes substantially zero, the liquid crystal material is deteriorated, and this is why such a reset voltage is used.
In the above-described driving method, the voltage +V0 /2 (portion A in FIG. 3) is applied in the reset period, so that light is transmitted even in an OFF period. In case of a display, the number of time division is as large as several hundred, and the reset period substantially becomes shorter, so that such a degree of leakage of the light during the OFF period is negligible. However, in case of a liquid crystal optical switch for a printer, in which the number of time division is around ten at largest, the leakage amount of the light in one frame term becomes relatively high. This causes the contrast ratio to decrease, and the quality of the printed materials of the printer to become low. Therefore, this driving method cannot be adopted as the liquid crystal optical switch for a printer.
An object of the present invention is to provide an apparatus and method of driving a liquid crystal optical switch for a printer, capable of attaining a high contrast ratio by preventing the leakage of the light during the reset period.
This object can be achieved by using a DC voltage signal of one polarity, which selects the light interrupting state, as a reset voltage, and applying a DC voltage of the opposite polarity to the liquid crystal switch at least a period except for the reset period, for example, the retention period or after a printing operation.
The other objects and characteristic features of the present invention will become apparent from the following description of the preferred embodiments.
FIGS. 1a-1c are diagrams showing the principle of the present invention;
FIGS. 2a and 2b are diagrams showing a conventional optical switch driving method and the waveforms of the transmitted light;
FIG. 3 shows waveforms of a conventional method of driving a ferroelectric liquid crystal display;
FIG. 4 shows waveforms of driving voltages in an embodiment of the present invention;
FIGS. 5 and 6 show a circuit for the driving method of FIG. 4 and the waveforms of voltages used therein;
FIG. 7 shows waveforms of transmitted light, which are used to describe the effect of the present invention;
FIG. 8 is a diagram showing a printer to which the embodiment of the present invention is applied; and
FIG. 9 is a diagram showing the construction of an optical switch in the printer of FIG. 8.
FIGS. 1a1c show the principles of operation of the present invention. Referring to FIG. 1a, a negative DC voltage signal having an amplitude value of +VR is applied only in a reset period to obtain a light interrupting state. In this embodiment, a voltage of a negative polarity is utilized to obtain a light interrupting state. However, a liquid crystal optical switch obtains a light interrupting state when a voltage signal of a negative polarity is applied, and a light transmitting state is obtained when a voltage signal of a positive polarity is applied. Additionally, a DC voltage component VK is applied as a bias voltage to a non-selected voltage signal electrode during the retention period TH. The amplitude of VK is expressed by VR �TR /TH, for example, the retention period or after a printing operation may have a step voltage value as long as it has a waveform having a positive DC voltage component corresponding to VR �TR.
The VK �TH may be not more than VR �TR as long as it has a bias voltage of a positive polarity that does not substantially deteriorate a ferroelectric liquid crystal and can reduce the DC component. When VK is applied, the complete light interrupting condition is obtained during the reset period, and a high contrast can be attained. This DC voltage is substantially converted into AC voltage to reduce the DC component in one frame term and preferably enables the average DC component of the voltage signal to be set to substantially zero, so that the deterioration of the liquid crystal material does not occur. When the number of time division N(=TL /TR) increases, TR /TH becomes smaller, so that VK also becomes smaller. Accordingly, the influence of VK upon the liquid crystal molecules during the retention period also decreases.
In the example of FIG. 1b, the amplitude of VK is zero. The average DC component of the voltage signal during one frame term is not set to zero. However, a DC voltage of a positive polarity, which is opposite to the polarity of the DC component applied during the printing operation, is applied collectively after a printing operation has been completed and/or before a printing operation starts to reduce the DC component and preferably set the average DC voltage component to substantially zero. TP is designated to be the time required to print at least one sheet of paper, the number of frames becomes TP /TL. Therefore, the unbalance of DC component of a negative polarity corresponding to VR �TR (TP /TL) occurs during the printing of at least one sheet of paper. In order to reduce this unbalance, a voltage VR ' is applied for the time TC after the printing has been completed in this embodiment. The time TC above is substantially equal to VR TR TP /(VR ' TL). Since a fluorescent lamp, which is utilized as a light source for the optical printer is turned off immediately after the printing operation has been completed, the light is not transmitted, and the printing operation is not influenced by the light. In this method, the bias component VK is not applied during the retention period, so that the method has an excellent retaining effect.
FIG. 1c shows a method of applying a voltage in a divided manner, i.e., in the period TH in which a voltage of a positive polarity corresponding to the wave height value -VR applied during the reset term TR is retained, and after a printing operation has been completed. Vl is a DC voltage of a positive polarity applied in the retention period, and VJ is a DC voltage of a positive polarity applied after the completion of a printing operation. The following relation is then established.
Vl�TH +VJ �TC =VR �TR �(TP /TL)
Next, some definite embodiments of the present invention will be explained with reference to a printer using a plurality of optical switches. Incidentally, it is apparent to those skilled in the art that the present invention can be applied not only to a printer but also to optical shutters, displays and the like.
In FIG. 8, reference numeral 16 represents a movable photosensitive drum; 18 is a charger; 14 is a liquid crystal optical switch array panel having a plurality of optical switches; 19 is an optical image formation element; 20 is an optical print head; 21 is a developer; 22 is paper; 23 is a transfer device; 24 is a fixing device; 25 is an erase lamp; and 26 is a cleaner.
The action of the printer described above will now be explained. The photosensitive drum 16 is provided with uniform electrostatic charge by corona discharge of the charger 18. When light is selectively radiated to this drum 16 by the optical print head consisting of a light source 8 such as a fluorescent lamp, the liquid crystal optical switch array panel 14 and the optical image formation element 19, only the electrostatic charge of the zone to which the light is radiated is extinguished depending upon the properties of the photosensitive member, thereby forming an electrostatic latent image.
There are generally two types of development, a reversal development in which the latent image formed on the portion of the photosensitive member to which the light was radiated by the optical switch in the light transmitting condition is developed with toner, and a normal development in which latent image on the portion of the photosensitive member to which the light was not radiated is developed with toner and the toner image is formed. The present embodiment will now be described in the case of the reversal development. In the normal development, the light transmitting condition and light interrupting condition are reversed.
As the paper 22 fed from a cassette is sent to the transfer device 23, the toner image is transferred to the paper by the force of an electric field, and the toner image is further fixed to the paper by a pressure or heat or light flash from the fixing device 24, forming a permanent image.
Any residual charge and surface charge on the surface of the photosensitive drum 16 are removed by the erase lamp 25 and the cleaner 26, and the photosensitive member returns to its initial state.
Next, FIG. 10 shows the structure of an optical switch element for a printer, which element uses a ferroelectric liquid crystal material 4. Orientation films 11a and 11b are formed on a fine signal electrode substrate 5a on which electrodes 6a for fine signals are formed (10 electrodes/mm and 2,048 electrodes in all), and on a common electrode substrate 5b on which a common electrode 6b is formed, respectively. An optical switch portion is disposed either two-dimensionally or in a two-dimensional array form, and the DOBAMBC liquid crystal 4 shown in U.S. Pat. No. 4,508,429, U.S. Pat. No. 4,591,806, U.S. Pat. No. 4,712,876 is then interposed in parallel between the substrates in a predetermined thickness (about 4 μm). The light 9 incident to the optical switch element 14 from the light source 8 is selectively passed therethrough by an electric field applied between the signal electrode terminal K1 -K2048 of each electrode and the common electrode 6b, and is spot-radiated onto the surface of the photosensitive drum 16 by a convergent lens 15. In FIG. 10, reference numerals 7a, 7b represent polarizers.
Embodiments of the present invention will now be described. FIG. 4 shows the waveforms of the driving voltage signals used in an embodiment of the present invention, in which the waveforms of the voltage signals at a scanning electrode and a signal electrode are set as shown in the drawing. The waveform of a voltage signal applied during the reset period of the scanning electrode is that of a DC voltage -2V0 of a negative polarity constituting one polarity, and the waveform of a voltage applied to a liquid crystal layer during the reset period corresponds to a change of the waveform of a voltage signal at the signal electrode. In other words, it depends upon the light transmitting condition for printing and the light interrupting condition for non-printing and it is either VR1 or VR2, respectively, as shown in FIG. 4. Since neither of these waveforms include a DC voltage component of a positive polarity constituting the opposite polarity, the leakage of the light does not occur during the reset period TR. Instead of this, a voltage signal having a DC component of a negative polarity -2V0 �TR is applied during the reset period TR, and therefore, a voltage signal corresponding thereto, i.e., preferably a voltage signal having a DC component of a positive polarity VK =2V0 TR /TH.
In this embodiment, a high-frequency AC voltage is applied in the retention period so as to stabilize the molecular orientation and improve the retaining effect. This is called a AC-field stabilizing effect and is advantageous where a liquid crystal material having negative dielectric anisotropy is used, and can prevent the bias voltage VK from rearranging the molecules. A method in which a high frequency AC voltage is not applied can also be used, of course. When a voltage is applied during the writing period Tw selecting the light interrupting condition in this embodiment, such a small voltage (�V0) that does not disturb the condition selected in the rest period, is applied to retain the light interrupting condition, and, only when the light transmitting condition is selected, a reverse voltage 3V0 is applied in the writing period.
FIG. 5 shows a circuit for driving at least one optical switch by the driving voltages having waveforms shown in FIG. 4, the circuit being adapted to carry out the time sharing driving of a duty 1/N having N scanning electrodes C1 -CN. A CMOS-IC driver is connected to a signal electrode S1, and a voltage pulse -V0 +V0 or +V0 -V0 is applied thereto in accordance with a data signal D1, which pulse forms the signal electrode voltage shown in FIG. 4. A voltage V1 shown in FIG. 5 has an AC voltage waveform having a pulse width of TL /2N and a wave height or amplitude value of 2V0 as shown in FIG. 6, and a voltage V2 is an alternating voltage having a frequency of 10-40 KHz and a bias voltage of VK, a voltage V3 being a DC voltage of -2V0. These voltages V1, V2, V3 are selected by multiplexers 121,122 . . . and form the scanning electrode voltages shown in FIG. 4.
FIG. 7 shows the scanning voltage signals VC1, VC2 applied to the scanning electrodes C1, C2, a signal voltage signal VS1 at the signal electrode S1, the voltage signals applied to the liquid crystal layers of the optical switches 11, 12 at the intersections of VS1 and VC1, VC2, and examples of the waveforms of light transmission amount B11, B12. The phases of VC1, VC2 are staggered by TL /N. Since a DC voltage of a negative polarity is applied during the reset period TR, the last part of the period TL of one line is put in complete light interrupting condition for non-printing. A voltage signal having a DC component VK of a positive polarity is applied continuously in the retention period TH, and a high-frequency AC voltage signal as superposed thereon. Accordingly, when the light interrupting condition is selected, it is retained excellently owing to the high-frequency stabilizing effect even if the liquid crystal element does not have a bistable memory effect. If the liquid crystal element has a bistable memory effect, the high-frequency voltage is not necessary.
As may be understood from a comparison between the waveform B11 shown in FIG. 7 of the transmitted light in the optical switch 11 and that OFF(A) shown in FIG. 2b of transmitted light, the light transmission amount during an entire OFF period in the present invention is very low. The light transmission amount during an ON period in the present invention is always substantially the same both when the ON period continues from an ON period and the ON period continues from an OFF period. Consequently, the contrast becomes very high, and the same contrast can always be obtained irrespective of the pattern of a printing signal.
According to the present invention, the light transmission amount in an OFF period can be minimized, and that in an ON period can always be set substantially equal. Moreover, the average DC component applied to the liquid crystal layer can be reduced. This enables a highly reliable optical switch driving method having a high and substantially invariable contrast provided by at least one optical switch to be obtained for printing purposes.
|Cited Patent
|Filing date
|Publication date
|Apr 13, 1983
|Apr 2, 1985
|Hitachi, Ltd.
|Method for driving liquid crystal element employing ferroelectric liquid crystal
|Jul 9, 1984
|May 27, 1986
|Hitachi, Ltd.
|Driving method and apparatus for optical printer with liquid-crystal switching element
|Sep 12, 1984
|Sep 30, 1986
|Casio Computer Co., Ltd.
|Recording apparatus
|Jun 11, 1985
|Oct 20, 1987
|Seiko Epson Kabushiki Kaisha
|Method and circuits for driving a liquid crystal display device
|May 5, 1987
|May 24, 1988
|Hitachi, Ltd.
|Multiplexed driving method for an optical switching element employing ferroelectric liquid crystal
|Feb 3, 1987
|Sep 6, 1988
|Takao Umeda
|Printer utilizing optical switch elements
|Jan 6, 1987
|Sep 13, 1988
|Hitachi, Ltd.
|Ferroelectric liquid crystal matrix driving apparatus and method
|Jul 6, 1988
|Sep 25, 1990
|Canon Kabushiki Kaisha
|Image forming apparatus
|Citing Patent
|Filing date
|Publication date
|Aug 16, 1991
|Mar 7, 1995
|Canon Kabushiki Kaisha
|Liquid crystal apparatus with gradation information signals and DC bias
|Oct 11, 1994
|Dec 26, 1995
|Canon Kabushiki Kaisha
|Ferroelectric liquid crystal apparatus having a threshold voltage greater than the polarization value divided by the insulating layer capacitance
|May 7, 1993
|Jan 14, 1997
|Seiko Epson Corporation
|Liquid crystal display device having two metastable states and driving method therefor
|Jun 14, 1996
|May 4, 1999
|Seiko Epson Corporation
|Liquid crystal display device having two metastable states and driving method therefor
|Dec 9, 1997
|Feb 29, 2000
|Eastman Kodak Company
|Liquid crystal printing apparatus for radiation thermal transfer of colorant from a donor to a receiver
|Jun 9, 1997
|Jun 6, 2000
|Seiko Epson Corporation
|Electrooptical element switchable between a plurality of metabstable states
|Sep 14, 1995
|Jun 26, 2001
|Seiko Epson Corporation
|Liquid crystal display device and its drive method and the drive circuit and power supply circuit device used therein
|Jun 7, 2002
|Mar 16, 2004
|Hewlett-Packard Development Company, L.P.
|Fluid ejection and scanning system with photosensor activation of ejection elements
|Apr 10, 2002
|Jun 8, 2004
|Hewlett-Packard Development Company, L.P.
|Laser triggered inkjet firing
|Jun 7, 2002
|Oct 5, 2004
|Hewlett-Packard Development Company, L.P.
|Photosensor activation of an ejection element of a fluid ejection device
|Oct 3, 2003
|May 17, 2005
|Hewlett-Packard Development Company, L.P.
|Fluid ejection and scanning system with photosensor activation of ejection elements
|Jun 7, 2002
|Aug 1, 2006
|Hewlett-Packard Development Company, L.P.
|Fluid ejection and scanning assembly with photosensor activation of ejection elements
|Jun 7, 2002
|Sep 12, 2006
|Hewlett-Packard Development Company, L.P.
|Fluid ejection system with photosensor activation of ejection element
|Jun 7, 2002
|Dec 11, 2003
|Samii Mohammad M.
|Fluid ejection and scanning assembly with photosensor activation of ejection elements
|Jun 7, 2002
|Dec 11, 2003
|Samii Mohammad M.
|Fluid ejection system with photosensor activation of ejection element
|Aug 5, 2003
|Feb 12, 2004
|Samii Mohammad M.
|Photosensor activation of an ejection element of a fluid ejection device
|Oct 3, 2003
|Apr 8, 2004
|Samii Mohammad M.
|Fluid ejection and scanning system with photosensor activation of ejection elements
|U.S. Classification
|349/3, 349/34
|International Classification
|Cooperative Classification
|European Classification
|Sep 9, 1991
Owner name: HITACHI, LTD.
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:UMEDA, TAKAO;NAGATA, TETSUYA;IGAWA, TATSUO;REEL/FRAME:005826/0281
Effective date: 19880906
|Aug 31, 1995
|Fee payment
Year of fee payment: 4
|Aug 30, 1999
|Fee payment
Year of fee payment: 8
|Aug 29, 2003
|Fee payment
Year of fee payment: 12


text:
Okla. trooper's use of force justified
PoliceOne spoke today with a contact we have at the Oklahoma Highway Patrol, who informed us that Troopers Tommy Allen and Daniel Martin have been cleared of excessive force accusations and have returned to their patrol duties. A review board looked at dash cam video of the incident and ruled that the force in the case was reasonable, justified, and furthermore, exactly what the agency trains its officers.
"It was a textbook case of escalation of force — one strike for compliance — and then a de-escalation of force," said our contact, who declined to have his name identified in this report.
Last week, the agency held a press conference during which officials said the troopers were justified in their use of force against Christopher Douglass. Oklahoma Highway Patrol has cleared Troopers Allen and Martin of any wrongdoing in the incident, which took place near the town of Holdenville (Okla.) in early October. On the other side of that coin, Douglass is now charged with obstructing a police officer.
The newly released video of the October incident shows Martin using a single strike to Douglass' leg in order to get control a subject who would have otherwise fled the scene.
"This could have been over, right here, if the person would have complied with the officers' directions," said Lt. Tim Tipton in that news briefing. "Twice so far, that [incident] would have been over with."
KJRH-TV, the local NBC News affiliate in the area, said on its Web site that, "based on the investigation and review board, Colonel Van M. Guillotte, Chief of the Highway Patrol, determined the use of force was justified, appropriate, and not excessive."
Another local television station quoted Lt. Tipton as saying — and quite correctly so — that sometimes the work that officers are involved with can get ugly. Sometimes cops have to put their hands on people. Looking at this case, it's clear that the use of force was appropriate.
"Once Trooper Martin felt this person was going backward trying to escape, that is when the strike is made," Tipton said.
Many PoliceOne members will remember Trooper Martin's name from another — totally unrelated — episode earlier this year. Martin had served a five-day suspension for a May 24th incident in which he "grabbed a paramedic in a choke hold around the neck" according to a report from the Associated Press.
Videotape from the dash cam in Trooper Martin's patrol car surfaced soon after the May incident, and almost immediately "went viral" on the Internet. FOX News, CNN, and numerous other national media organizations rushed to present the video in their broadcasts. That video showed "paramedic Maurice White Jr. repeatedly telling Martin he has a patient in the back and wants to go to the hospital," said one Associated Press report posted to PoliceOne in mid-June.
PoliceOne received links to the video from dozens of our members, and posted several reports from the mainstream media chronicling events in that episode.
According to reports, the district attorney looked at the video and other facts of the case and declined to file charges against either Trooper Martin or EMT White.
Recommended Use of Force
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text:
Top Definition
Bright, Brightly Colored, Striking
The dress was a vivid color.
লিখেছেন- Nerd21 6 de এপ্রিল de 2009
Trending Now
Can you define these popular missing words?
A woman so hot, she could be an A-list porn star (reference Vivid Girls).
Did you see that bird? She is fit. Where?...oh yeah, she's vivid.
লিখেছেন- blitzMono 1 de ফেব্রুয়ারি de 2009


text:
Attache Pro 4GB USB Memory
4.0 stars
Capacity, read-write performance, data security
Build quality
Whatever you call them, memory sticks, flash or thumb drives, we find it hard to get excited by the things. Usually.
The PNY Attaché Pro got the hair on the back of our necks standing firm though, thanks to the none-too-shabby 4GB capacity coupled to a truly stonking performance.
The read speed of 29MB/s is darn fast, as is the write speed of 17MB/s it has to be said. One thing you won't be doing is blaming this memory stick for keeping you hanging around as you appropriate the MP3 collection from your mates PC. And once appropriated, nobody will be able to access the files if you misplace the drive or someone gets a crafty 10 minutes with it, thanks to the supplied Secure Lock software.
What sets this apart from your run of the mill stick security solution, and all but the lowest budget devices have realised that protecting user data helps sell the things, is the fact that it doesn't need to be installed on your PC. Instead, it is pre-loaded on the drive itself and just requires you to set a password to get started. Once done a 128-bit AES encryption system protects what shows as a "virtual disk" on whatever PC you stick your stick into. You can increase the storage capacity of your secure virtual drive from the basic 128MB right up to the full 4GB if you must, but it's probably best to leave a little free for straightforward non-secured access just in case. Forget your password, by the way, and you'll have to reformat the USB drive and lose all the data held upon it.
Measuring just 80mm x 20mm x 11mm and weighing in at 13g the PNY Attaché Pro is one of the smaller devices on the market, albeit not the toughest. Unluckily for PNY we had a SanDisk Cruzer Titanium to compare it to, and there was none. Comparison that is. The PNY leaves the USB connector exposed, protected just by an easily misplaced cap, whereas the Cruzer goes for the much safer retractable connector option. Equally, the PNY body is made from fairly tough plastic yet with enough flex to cause us a little worry. The Cruzer's tough titanium body leaves you feeling comfortable about your Auntie Ethel sitting on the thing, and while not flimsy we wouldn't say the same of the PNY. However, PNY do supply a 2-year warranty which should be enough to qualm any fears.
Fast and furious sums up the Attaché Pro: fast performance and curios security. If you need to get access to your data as quickly as possible while ensuring nobody else can, then look no further. Handily, £119 for 4GB of such storage is damn fine value as well.
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Forum indexLeica TalkChange forum
More M10 rumors
Started Aug 22, 2012 | Discussions thread
Shop cameras & lenses ▾
MatjazVrecko • Regular Member • Posts: 164
Re: More M10 rumors
In reply to monoblocks • Aug 23, 2012
Willl there be any zoom capabilities in the viewfinder? If so, it could be of great help in pinning down the focus right,... and all rangefinder calibration problems would be
instantly gone with that,...
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|Aug 22, 2012
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Ratings based on 84 Verified Reviews
They paid and stayed. We double-checked.
4.2 Room cleanliness
4.3 Service & staff
4.1 Room comfort
3.9 Hotel condition
Expedia Verified ReviewsThey paid and stayed. We double-checked.
by A verified traveler from Colorado
You can do better for your moneyPosted Nov 30, 2015
Pros: Staff was friendly
Cons: New sheets, towels and coffee pots
Disappointed. Coffee pot had nasty stuff in it. Towels and sheets are old. Just not worth the money
by Austin from North Carolina
Great StayPosted Nov 23, 2015 on Hotels
Stayed here for my girlfriend's Bday weekend. We loved the Jetted tub and the Continental Breakfast was the best around! Good pricing due to Hotels.com
by Elroy from wanblee sd
outstandingPosted Nov 10, 2015 on Hotels
It's the top of the line place to stay highly recommended
by Owen from Kansas City
Overnite from ManhattanPosted Nov 3, 2015 on Hotels
competitive price for quick business trip between Manhattan and El Dorado
by A verified traveler
Visitor from LarryvillePosted Oct 26, 2015
I am a non-smoker and I mistakenly booked a smoking room for a two night stay. They were booked up for that night, (the whole town was booked solid), and couldn't switch me but gave me some air freshening spray to help with the odor. They had openings the second night and were able to switch me to a smoking room the second night. They were extremely helpful, courteous, and respectful through the whole process. Thank you! Rooms were clean and the light blocking curtains that could be pulled completely shut were very welcome. Parking lot lights didn't keep me awake. Been to to many hotels that had just sheer curtains and decorative side curtains that couldn't be pulled shut. Complimentary breakfast was better than most with a wide selection of well prepared fresh items.
by A verified traveler
Posted Oct 16, 2015
This was a good price and close to our destination for a football game. The continental breakfast was good as was the service from the desk staff. I was a bit disappointed with the condition of the room - needed to be painted. The light over the sink didn't stay on and wasn't looked at during our stay.
by A verified traveler from Tampa, Florida
Close to Ft. Riley.Posted Oct 16, 2015
Pros: The staff, mostly Susan the GM was fantastic. Great customer service. We where a tad disappointed in the room as it had all real old decor, beat up!
Cons: Remodel.
Location: Ft. Riley to see our son was close. Another restaurant to stay away from is Piggins BBQ. Lousy food and way overpriced. Would not recommend to any 1
Stay away fro La Hacienda, the food was so so however the abundance of FLIES where overwhelming. Piggins BBQ in Manhatten, KS is another one to stay away from. Lousy food and way, way overpriced!!!!!
by A verified traveler
Game Day HotelPosted Oct 13, 2015
Room was clean and ready when I got in at 1AM. Breakfast the next morning was hot and more offerings than I expected.
by Frank from St. Charles
Posted Oct 9, 2015 on Hotels
Quick overnight stay. Comfortable and very good breakfast.
by Clifford
Posted Oct 7, 2015 on Hotels


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What if we saved planet Earth? What if we conceded that there is no technical solution? What if we adopted all the recommendations of environmentalists, restricted our own freedoms, and changed our... More > ways tomorrow? What would the future look like then? What would humanity look like? The Yates twins, Anna and Aurora, are born into a true aristocracy: one determined not by gender, ethnicity or culture, but by species. Although they are raised with the paradigm that genetics is the most important factor in defining their identities, these two very different sisters know there is more to who they are. When a rogue group of government scientists reveal the depth of institutionalized discrimination, Anna and Aurora know they must fight for the cause of equality. Set to the backdrop of a revolution, this is the bittersweet story of a family caught in the middle of a political struggle and torn apart by extremism.< Less
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ACE Fit Share
Build up your biceps and triceps with these simple arm exercises from the American Council on Exercise. Learn valuable how-to information and get expert fitness advice that will help you strengthen your arm muscle groups including the biceps, triceps and wrists. We have a wide variety of arm strenghtening exercises from the beginner to advanced level including the dumbbell bench press, triceps kick-backs, bicep curls and more. For full workout routines that feature arm exercises, check out our Workouts section.
Fit Life Articles
It can be challenging to eat healthy on vacation, especially if your adventure includes a lot of time spent on the road. But with a little pre-planning and some mindfulness, you can eat healthier on your trip, even when your choices are limited!
If gaining weight is your goal, it's important to do so in a mindful way, paying close attention to both what you eat and how much you eat.
Strong glutes are essential, not only for aesthetics, but also for reducing your risk of injury and low-back pain. Plus, powerful glutes enable us to become more agile, jump higher, lift heavier, climb stairs, walk and/or run with less stress to the lower-chain joints,...


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Trust N Luck, who stood his first three seasons at Dr. Tom Simon's Vinery near Lexington, is moving to Vinery Florida for the 2007 season.A son of Montbrook, Trust N Luck will have his fee reduced from $6,500 to $5,000 for his first season at the farm near Summerfield, Fla.Trust N Luck won the Fountain of Youth Stakes (gr. I) and finished second in the Florida Derby (gr. I). In all, he won five of 12 starts and earned $727,484. He is out of the Dahar mare Bold Burst."Given his success while racing in Florida and the popularity of his sire, Montbrook, he seems a natural fit for our Florida stallion operation. We are very excited to present him to Florida breeders, and we anticipate a strong and immediate response," said Vinery Kentucky co-general manager Ben McElroy.
Trust N Luck Moving to Florida
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Tonight on Nightly Business Report, the economy added 175,000 jobs in May, sparking a rally in stocks. But are Americans feeling better about the labor market and what does it say about the Fed's next move?
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ACE Fit Share
Build up your biceps and triceps with these simple arm exercises from the American Council on Exercise. Learn valuable how-to information and get expert fitness advice that will help you strengthen your arm muscle groups including the biceps, triceps and wrists. We have a wide variety of arm strenghtening exercises from the beginner to advanced level including the dumbbell bench press, triceps kick-backs, bicep curls and more. For full workout routines that feature arm exercises, check out our Workouts section.
Fit Life Articles
Eating enough protein is essential for both maintaining and losing weight, as well as for helping muscles repair after workouts. But exactly how much protein do you need? Learn why you may be underestimating your protein needs and how you can get more protein in your diet....
If you're having fun while moving your body, it's easy to forget that you're exercising. That's why it's critical to find creative ways to make physical activity more enjoyable. From walking your dog to playing an informal game of tag at a family gathering, making movement...
With the government's recommendation to get in 10,000 steps per day, can we all realistically accomplish this daily step goal? Yes, we can. It will take a more conscious effort to do this if you live in a more rural or suburban area but it can be done.


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Season 3, Episode 6 Advanced Gay
First Aired: November 3, 2011
Pierce throws a party to celebrate the popularity of his wipes, but his dad (Larry Cedar) shows up and puts a damper on the festivities. Elsewhere, Troy becomes a hot commodity for Vice Dean Laybourne (John Goodman) and a janitor (Jerry Minor).
Guest Cast
John Goodman Vice Dean Laybourne
Larry Cedar Larry Cedar Cornelius Hawthorne
Jerry Minor Jerry
Cast & Details See all »
- Premiered: March 17, 2015
- Rating: TV-PG
- Premise: A comedy series about an oddball group of students attending a community college in Colorado. (more)
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project accountant jobs near Plano, TX
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Sr. Staff Accountant
Omnilife USA, Inc. - Plano, TX
Ad hoc projects. Review accounting data for accuracy and compliance with GAAP....
Certified Public Accountant 50-70K
The MB Group LLC - Plano, TX
Certified Public Accountant - CPA*. Ability to manage multiple concurrent projects. Due to exceptional growth, we are seeking an experienced CPA to service our...
Revenue Accounting Manager
VIP Search Group - Irving, TX
Strong project management and negotiation skills. This highly visible position will serve as the primary accounting contact over an assigned group of...
Staff Accountant - Fixed Assets
Tuesday Morning - Dallas, TX
Perform special projects as needed. Maintain Fixed Asset files by store or project code. Maintain the Fixed Asset System to insure that assets have been added...
Senior Accountant
Guardian Construction - Carrollton, TX
Hands-on experience managing all functions of corporate and project accounting. Commercial General Contracting company located in Carrollton is looking for a...
Staff Accountant - CULINAIRE Corporate Office
CULINAIRE - Dallas, TX
Perform assigned projects, i.e., audit schedules, tax schedules, etc. CULINAIRE, a national food and beverage management company with corporate offices located...
Operational Accountant (Construction Industry)
Republic Elite - Addison, TX
Reconcile billing and collections on projects in progress. Maintain third party lien tracking services and lien rights on projects in progress....
Staff Accountant - Ownership Group
Highgate Hotels - Irving, TX
Other special projects and responsibilities, as. Accounting for construction and other FF&E projects. This position assists the Corporate Accounting....
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CompuCom - Dallas, TX
The accountant is primarily responsible for various general ledger duties including assisting with month-end close duties, helping with external audits, and ad...
PSMAG Financial Projects Coordinator
CGI - Dallas, TX
Track, analyze, and report on monthly expenses across multiple projects. Assist with invoice tracking, revenue recognition, reporting, etc. across multiple...


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Chicken and Ginger Congee (Chinese Savoury Rice Porridge) - Gaby Ho
Tue 26 Jul 2016, 2:15pm by Lish Fejer
This is a Cantonese version of congee, similar to the congee my dad would make on weekends. His favourite topping is youtiao, Chinese savoury donut. You can buy youtiao from Asian supermarkets or sometimes at Chinese restaurants which sell BBQ ducks. If you?re feeling adventurous, try adding century eggs. Century eggs have been fermented for a number of weeks in a mixture of lime, ash, charcoal, salt and tea. They have a unique gelatinous texture and intense flavour. Find salted duck eggs and century eggs at Asian supermarkets. Read more


text:
The young author Emrah Serbes is regarded as the "enfant terrible" of Turkish literature. Not only is he one of the most popular authors in Turkey: since the protests in Gezi Park last summer and his active participation in the resistance, many now seen him as the "writer and voice of the people". Ceyda Nurtsch met him at a reading in BerlinMore
With his first feature film, "Ummah – unter Freunden," the German-Turkish film director Cüneyt Kaya deliberately confronts viewers with a world that stands in sharp contrast to prevalent prejudices. The film, set in the Berlin problem district of Neukölln, can be taken as an invitation to get to know the Muslim community. By Anke SterneborgMore
Millions of viewers in Turkey are hooked on a television series about the Ottoman ruler Suleiman the Magnificent. Prime Minister Erdogan, on the other hand, wants the series taken off air. Jürgen Gottschlich reports from IstanbulMore
Rawabi (″the hills″ in Arabic) – vision of Nablus-born entrepreneur and billionaire Bashar al-Masri – is the first planned Palestinian city and the largest private sector project in Palestinian history. Mockingly referred to by some as ″the first Palestinian settlement", Rawabi is not without its critics, who argue it merely serves to sugarcoat the Israeli occupation.
The development has also faced difficulties connecting to the water supply: infrastructure had to be built across Area C, the 60 percent of the West Bank under Israeli civil and security control – the necessary permits were eventually granted, but the main access road remains unauthorised. By Ylenia Gostoli


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Article Tools
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A Scranton physician indicted on charges he conspired with his wife to illegally structure bank withdrawals is suffering from terminal cancer and did not do anything to warrant action taken by prosecutors, the couple's attorney said Wednesday.
Attorney Christopher Powell said Dr. Leroy Pelicci and his wife, Ann, legally earned the $431,500 at issue. He blasted the U.S. attorney's office for seeking the indictment, saying it's the first time he's aware federal prosecutors ever took such an action without evidence the funds involved were tied to another crime.
"This is not usually a standalone crime. ⦠There are 152 reported cases. In every one of those, the charges were connected to some other crime," he said. "All the money was legally earned . . . A dying man ought to be able to do what he wants with money that he's earned."
The indictment alleges Dr. Pelicci, owner of the Pelicci Pain Center in Scranton, and his wife made 49 separate withdrawals, most of which were for $9,000, from January to July 2012 so they could evade regulations that require banks to report any transaction of $10,000 or more to the Internal Revenue Service.
Such transactions are illegal under a federal statute that's designed to protect against money laundering, a crime that involves transferring illegally earned money to make it appear as though it was legitimately earned.
Records review
The indictment says the couple made the structured withdrawals after they were advised in May 2011 that the pain center's billing records were "under review' by state agencies. It does not identify the agencies or detail the nature of the review.
Mr. Powell denied there is any active investigation into the pain center. He said the center's billing practices were questioned in the early 1990s by Blue Cross/Blue Shield, which disputed the diagnostic codes Dr. Pelicci used for certain services. That led to an "attempt" at a criminal investigation, but nothing ever came out of that probe.
"It was an internal investigation by Blue Cross/Blue Shield, who challenged the doctor on the codes," Mr. Powell said. "It never went anywhere. ⦠The codes are subject to interpretation."
Mr. Powell said the money in question was transferred from a single mutual fund account into several banks accounts. The couple made the series of withdrawals because they wanted to have cash on hand, in part because of Dr. Pelicci's illness. He said he does not know why they chose $9,000 increments, but he does not believe they intentionally tried to evade reporting requirements as they did not even know a law existed regarding that matter.
Prosecutor persists
Advised of Mr. Powell's comments, U.S. Attorney Peter J. Smith said the indictment does not say there is a current investigation. It indicates there was an investigation going on in May 2011. Mr. Smith said he could not provide any further details of the outcome of that probe or identify the agencies involved. He noted the charges filed do not require the money involved in the structuring to have been illegally obtained.
Mr. Powell also criticized the government for seeking a warrant, filed the same day as the indictment, to seize and/or freeze $431,500 in a bank account held by Mrs. Pelicci. He said such an action is rare, particularly because there is no "victim" in this case.
"When you seize money it's usually to protect it to give it to a victim. There is no victim. There was an error if (prosecutors) are right, but there is no victim," he said. "In this case, they're seizing $400,000 from a sick man. It's ridiculous."
Mr. Smith said he considers the government to be the victim in the case. Prosecutors took action they believe is necessary in order to protect the funds.
"Given the nature of the charges, our conclusion was (the seizure warrant) was reasonable," he said.
Contact the writer: firstname.lastname@example.com


text:
The North American Trivia Test
Their result for The North American Trivia Test ...
You scored 15 American Logic Points!
Their Analysis (Vertical line = Average)
They scored 15% on Knowledge, higher than 11% of your peers.
All possible test results
Hmm out of 27, you're either blind, or just plain ignorant to your surroundings. Read more
Out of 27. You're pretty dumb when it comes to your surroundings... Take a look around!! Read more
Out of 27. Not horrible, but not good either... You need to get up from your computer and go outside for a while. Read more
pretty good
Out of 27. Wow, you actually look around every once in a while. Congratulations. Read more
Out of 27. You actually have some American logic, but hopefully you didn't cheat... Read more
Out of 27. You cheated, quit lying to yourself... Ok, if you didn't cheat please don't get offended then email me and tell me you didn't cheat... its just an online quiz thing. Read more
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What About Brian 2006 | TV Show Watchlist
Season 2, Episode 8 What About Secrets...
First Aired: December 11, 2006
Brian and his dad (William Devane) are driven apart by a secret involving Bridget (Krista Allen); Jimmy runs a criminal-record check on Heather; Deena decides to go out with T.K. (Brennan Elliot) following a couple of "practice dates"; and Dave lends moral support to Nicole when he accompanies her to a screening of Angelo's last movie, where she meets a mysterious woman with a connection to her late husband.
Guest Cast
Jane Sibbett Jane Sibbett Tracy
Rachelle Lefevre Heather
William Devane Michael Davis
Richard Molinare Richard Molinare Director
Sean Wing Sven
Krista Allen Bridget Keller
Alejandro Furth Alejandro Furth Counselor
Ryan O'Connor Ryan O'Connor Baker
Flynn Beck Flynn Beck Devin
Sean Smith Sean Smith Bob
Carlease Burke Patti
Cast & Details See all »
- Premiered: April 2, 2006
- Rating: TV-PG
- Premise: Chronicling a 34-year-old guy's search for true love. Brian's the last unattached person in his circle of friends, and making matters worse is the fact that he has `serious feelings' for his best friend's fiancée. (more)
Trending TonightSee all »
Bobby Jones Gospel8:00 pm | BETI'll Watch267 Watching
The Last Ship9:00 pm | TNTI'll Watch113 Watching
Big Brother8:01 pm | CBSI'll Watch87 Watching
What About Brian - The Complete Series
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Popular Shows
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- 2. UnReal
- 3. Mr. Robot
- 4. Game of Thrones
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Popular Celebrities
- 1. Rami Malek
- 2. Taylor Schilling
- 3. Constance Zimmer
- 4. Emilia Clarke
- 5. Tom Hiddleston
- 6. Kit Harington
- 7. Gina Rodriguez


text:
One could think of less patriotic ways to celebrate Independence Day than by checking out this free Governors Island gig by Rosanne Cash, who is playing in support of last years The List, on which she covered a dozen of the 100 classic country songs once recommended to her by her dad, the late, great Johnny Cash. (Those that made the cut include Long Black Veil, Bury Me Under the Weeping Willow, and Bob Dylans Girl From the North Country.) No word if Cash plans to fill out her set this afternoon with the likes of America the Beautiful and The Star-Spangled Banner, but, given her flair for interpretation, it might just happen.
Sun., July 4, 2 p.m., 2010
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Posted by Brenda
Our case seemed cut and dry at the beginning. As it began to drag on Greg was patient. Was able to explain any questions we ever had. Greg dealt with all curve balls that was thrown out our way. Was available 24/7 via phone, text, and email without making us feel like we were taking up any of his time. Greg is a very knowledgeable lawyer. He is very responsibly priced. I could not have asked for anyone better. We feel we are very blessed to have found Greg Decker. I would refer him to anyone one in a heartbeat. If your looking for the best lawyer, someone who does not take you to the cleaners financially, knows what he is doing, and who is a gentleman the you need Geg Decker on your side!
Posted by a client
Greg has been responsive and is experienced with the details of family law in both Idaho and Washington. Each time I've asked a question he either knew the answer or researched it and answered me back, instead of handing me off to one of a variety of assistants with limited experience. He takes the time to fully understand the client's situation, stays in touch and doesn't make them feel like a number on a waiting list.
So, thank you for that and I'm happy to recommend you to someone I know. It's been a nice change from previous experiences I've had. Also, the ability to work between Idaho and Washington has been tremendously helpful in my situation.
Posted by Brian
Mr. Decker is an amazing lawyer. I live in Washington State, but my child lives in Idaho. Nice thing is that Mr. Decker can do both states if ever needed. His office is fast and efficiant. I will forever be a client of this office.


text:
North Coast Rep stages Ain't Misbehavin' with triple-threat actors
Waller's songs tell stories.
Jeff Smith 6:45 p.m., July 27
An ongoing read and critique group. Writing prompts will be given for participants to use if they desire. Members pay monthly for their participation.
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text:
End has been wrong with just about EVERYTHING he has posted.
He is simply full of BS.
Of course, IMO.
Mayo clinic was the #1 hospital in the new 2014 US and World Report. Just saying.
I saw a yacht in Dana Point, CA harbor recently with the name "Just Sayin".
Sentiment: Strong Buy
Same old document from March. Why do you say it's new?
End is usually pretty good. However I agree his post is just recycled rhetoric for the time being..
He means latest (newest) brochure from MAYO. What's noteworthy is that they don't even mention INCY's Ruxolitnib as a treatment for MF under their hematological cancer heading. Remissions trump comfort at the MAYO.
New Drug Induces Remissions in Myelofibrosis
The results of a Mayo Clinic study demonstrate that
a drug named imetelstat induces remissions in some
patients with myelofibrosis. This is a form of chronic
leukemia that affects the patient's bone marrow
that is replaced by fibrosis (scar tissue) instead
of blood-producing cells.
Scientists do not yet know the exact mechanism of
acttion for imetelstat, but believe it interferes with the
survival and proliferation of cancer cells by inhibiting
a critical enzyme called telomerase. One of the functions
of telomerase is to repair the ends of chromosomes
called telomeres, and because cancer cells have shorter
than normal telomere size, they are particularly susceptible
to the drug.
The study results are promising. Some patients
participating in the clinical trial taking imetelstat obtained
dramatic responses, and we have seen some complete
responses (tantamount to a cure), which is almost
unheard of in this disease.
Research is the fundamental reason that people across
the globe are living longer, healthier lives.
Mayo Clinic applies basic science to unlock the
destructive secrets of cells and discover how to repair
or reverse the damage. We then translate that knowledge
into first-time cures and treatments for a wide range
of life-threatening diseases and chronic conditions.
Patients receive research-driven care at Mayo Clinic,
which possesses a long legacy of providing a
team-based approach to integrating patient care,
research, and education.
Although patients may experience relief in response
to other treatments, their bone marrow does not
usually return to normal. But in the case of this new
therapy, some of the patients participating in the trial
developed normal bone marrow.
Researchers studied imetelstat in 33 patients at
Mayo Clinic and have now followed the first 22 patient
Great GERN info.
Sentiment: Strong Buy
remove all x AND add w
But more breakthroughs are necessary for our patients.
We need to better understand and more effectively treat
diseases ranging from the most prevalent like cancer
to the rarest disorders. In such spectrum of diseases,
we need to know why communication between cells
breaks down.
Generous donors enable Mayo Clinic to spearhead
the most advanced research and offer hope to patients
around the globe in the form of new treatments and
technologies. By investing in Mayo's research programs,
benefactors contribute to developing faster treatments
and cures for patients who need them now.
Research is the fundamental reason that people across
the globe are living longer, healthier lives.
Mayo Clinic applies basic science to unlock the
destructive secrets of cells and discover how to repair
or reverse the damage. We then translate that knowledge
into first-time cures and treatments for a wide range
of life-threatening diseases and chronic conditions.
Patients receive research-driven care at Mayo Clinic,
which possesses a long legacy of providing a
team-based approach to integrating patient care,
research, and education.
The results of a Mayo Clinic study demonstrate that
a drug named imetelstat induces remissions in some
patients with myelofibrosis. This is a form of chronic
leukemia that affects the patient's bone marrow
that is replaced by fibrosis (scar tissue) instead
of blood-producing cells.
Scientists do not yet know the exact mechanism of
action for imetelstat, but believe it interferes with the
survival and proliferation of cancer cells by inhibiting
a critical enzyme called telomerase. One of the functions
of telomerase is to repair the ends of chromosomes
called telomeres, and because cancer cells have shorter
than normal telomere size, they are particularly susceptible
to the drug.
The study results are promising. Some patient
Yes the Mayo Clinic is bragging about GERN's miracle.
Monday is GERN's day.
Sentiment: Strong Buy
End, you have provided a good layman's explanation of the neoplasm disorder (under Joanie's response in here). Scientifically, gene mutation causes the onset of inbalance and the disease spreads as cancer cells produced by the mutation multiply a lot faster than the normal ones in the blood. The process of cancer-cell multiplication is terminated when the telomeres at the ends of the chromosomes are stopped from growing. I understand, by depriving them of the telomerase. My understanding is that Imetelstat is effective in doing this. Thus, with growth of cancer cells curtailed, the proportion of normal cells in the blood grows again and the blood becomes normal when all cancer cells die. However, my puzzle and questions are related to what happens to the gene-mutation process? Was that just a one-time occurrence that disappears when all cancer cells die? Does Imetelstat work only in obliterating supply of telomerase to cancer-cell telomeres or goes beyond that and repairs also damage to chromosomes? Irish's post below suggests that it does that too! But, then, the question remains as to how it does that, and if that process causes any other undesirable side effect? Does the LFT abnormality have anything to do with such a side effect and why? I think that is where the FDA's concern may lie. A detailed genomic study may also be in order. All this study is apparently too much for the current scientific-investigation capability and staffing of Geron because its management seems to be focused elsewhere! Therefore, I consider it inept. Luckily, we have Mayo and Tefferi to help in this regard; but, collaboration with a resourceful and compatible partner may become a necessity. This is neither Scarlett's nor Huh's cup of tea!!
Since this a Yahoo board, I think it will be wise to go no further deeper into this matter. Thanks for your detailed reply.
Yog, few people here get it. Imetelstat is not a drug for treating liver function disorders, and if patients receiving imetelstat already have poor liver function test results prior to treatment, then we would not expect that to improve much following treatments. Except that we know that it did help reduce an enlarged liver in one patient. This could indicate some positive results regarding liver health, but it is not mentioned here in discussions. If we were to have data that all patients who receive imetelstat have good liver funtion test results prior to receiving imetelstat, and in a few weeks or months, we begin to see poor liver function test results, then we have the manipulated variable isolated. Otherwise, it is just a poorly designed experiment and it does not allow us to isolate a cause. No reporters are telling anyone this fact. It is clear to me that right now we do not have good baseline data on liver funtion prior to IV treatments of imetelstat for the FDA to say imetelstat is the causitive agent of liver function disorders. Maybe the Mayo Clinic has it, but it could be that the FDA did not ask for it when the Mayo Clinic initiated its trial and so the baseline data are largely missing?
Sentiment: Hold
Yog, whew! If I were with the FDA, I would be wanting to see the baseline data on what the liver funtion was like prior to treatment with imetelstat, because Geron tends to get the refractory patients that have been treated wtih other drugs! How did those drugs affect their liver function? No FDA official should ignore such facts; it is quite important to know what liver function tests results were prior to any treament with a new drug. Also, during treatment with imetelstat there could be immune system problems due to the fact that it is an immuno-suppressive drug, which might allow for endotoxin build up (the average healthy person has about 6 pounds of microbes in and on his/her body), and thus affect liver fuction. A single bacterium can grow from one to 2 followed by 17 zeros in about 24 hours. Also, I would look at hyperbilirubinemia and say did you try to treat patients with this disorder, upon discovery, with light? Why not? Moreover, one would hope that the FDA staff understand statistics well enough to know that 8-10 patients with similar disorders does not really tell us much without far more information gathered from a larger group of patients with similar neoplasm disorders. They should know about continuous random variables with such patients aside from the small number of them. One has to know liver function test results at the beginning, especially with other treatments being common for patients coming in for imetelstat.
Sentiment: Hold
Mr, What you call "the gene mutation process" must be better understood. My question is how does it happen that gene's mutate to create known types of mutation that are classified, such as Jak2. That the mechanism of mutation is not entirely random forces a search for what causes the types of mutations that occur, or makes them more or less likely to happen. I am not familiar with the mutation process, but I am assuming that for any of the mutation types to take hold and alter the normal cells, their must be a significant tendency to generate the specific mutation and it must occur frequently to overcome the cell blueprint. I think it is Darwinian to some extent as certain mutations have advantages and they survive in an adverse environment
There is a lot of effort ongoing to classify types of mutations. Apparently there is a catelog of most likely or possible mutations and different ones lead to different health problems. At the stage medicine is in, they are listing the mutations, and defining their characteristics, but they are not far along on understanding the gene mutation process in the sense of understanding its causes. Some macro causes, like smoking are known, but what about the micro causes, those that occur chemically. How are those stopped or undone; and if you do stop it, will it be a temporary stop or not. What is necessary to undo the conditions that lead to the mutation process?
If Imetelstat can block telomerase and stop neoplasm growth that has begun, and if the normal stem cells can fight back to gain control and restore blood balance, then how do you keep things that way so the aberrant conditions will not recur? Do you keep giving Imetelstat or what do you do to change the condition that started the disease in the first place? Or do you need to do anything once you restore normalcy? Can the bodies natural systems keep the blood balanced once the neoplasm is stopped and driven out?
We know the stuff works, testimonials by patients are real, truthful and honest. The simple truth is that the data requested by the FDA should have been available by the push of the enter button on a PC. The data not being available demonstrates that the skills of Geron Management are questionable. Let me see if I have this correct, you have been running FDA approved trials for 2 + years, you know the parameters of the information that you must provide to the FDA and you do not keep those records. They deserve to be sued. Unfortunately, we the stock holders are the ones who pay for it and the patients who need this miracle drug. When I lose my investment due to incompetency that makes it even worse and I get really xxxxxx. Scarlett, sell the company, supposedly this is your skill set. At the very least and with the information you have from MC, you should be able to get at least 18 to $24 a share. its worth that even with the hold. Incompetency does not even begin to describe these folks. Oh and lets not forget, every little dog and pony show that comes up, Las Vegas, New York, ETC. Scarlett attends at company expense instead of staying in the home office and turning on the after burners to obtain the information that the FDA seeks to get this hold lifted. IMHO, of course and I did not participate in any of the class action stuff. I'm just xxxxxx, its been long enough.
Thank you end. Unfortunately I doubt you learned of this important information on GERN's website or in a published article in the wall street journal paid for by GERN.
Scarlett believes in the old rule Silence is golden.
Good luck with GERN
Thanks for the info...great stuff...
end - thank you. I am looking forward to the new edition of the brochure! The one that could inform readers as to the new JAK2+ MF remissions, the cytogenetic remissions (e.g. chromosome damage repair), the now known mechanisms of action (e.g. genetic architecture), the success with other blood cancers, and the promising applications in other non blood cancers with splicing mutations - IMO.
Irish, Are you saying that the MC is combining Imetestat with Jak2 drugs to make what you are calling Jak2+ to reverse chromosome damage? Is there some reason to suspect that the two work together synergisticly?
When is the new edition going to be available?
What is JAK2+
JAK2 with imetelstat added to it?
Wow ! You are describing a lot of new stuff !
Sentiment: Strong Buy
and the stock (save for a message board induced but short lived spike of a few pennies), resumes it's sad and slow downward trend.


text:
Computers have been used for decades to get practical work done in the field of human genetics for the benefit of patients and the advancement of science. Computer algorithms and programs for linkage analysis have formed the foundation of most disease–gene discovery projects, and databases of clinical findings have been widely used to support diagnostic decisions in the fields of dysmorphology and general human genetics. A number of trends and recent developments, including next-generation sequencing (NGS), bio-ontologies and the Semantic Web, and the ever-increasing role of hospital information technology (IT) systems and electronic health records, are confronting human genetics researchers with growing amounts of information that can be difficult to interpret. However, the rapid development of cutting-edge bioinformatic tools is allowing clinicians and scientists to analyze these data more efficiently and accurately, with the end result being improved clinical care and research.
This special issue of Human Mutation reflects the views of a number of international leaders in bioinformatics as applied to human genetics. Many were recruited from among the esteemed attendees of the May 2010 Human Variome Project meeting at UNESCO in Paris [Kohonen-Corish et al., 2010]. There are now so many areas in which human genetics stands to profit from improved computational support, that it would be impossible to include all relevant topics in a single special issue. The articles presented aim to identify the promise—what human geneticists who are not themselves bioinformaticians stand to gain—as well as the challenges and unmet needs that are likely to represent fruitful areas of research in the not-too-distant future.


text:
Discover a selection of top forums pokestadium community on the internet. Come to share your passion on forums pokestadium community and meet other fans of pokestadium community. Then, why don't you create your own forum of pokestadium community ?
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text:
OSI-Approved Open Source (58)
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WinSCP ::
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Windows X-server based on the xorg git sources (like xming or cygwin's xwin), but compiled with Visual C++ 2012 Express Edition. Source code can also be compiled with VS2008, VS2008 Express Edition and VS2010 Express Edition, although current project and makefile are not fully compatible anymore. Versions starting from 220.127.116.11 are not compatible with Windows XP anymore.2,129 weekly downloads
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Native Midnight Commander 4.8.13/14 for Windows/Win32505 weekly downloads
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text:
Almost Perfect TV Show Watchlist
Season 1, Episode 20 Lights, Camera, Mike
First Aired: March 18, 1996
Kim offers Mike a part in an episode she's directing; but his minor role has a major effect on the scene when he points out its factual flaws. Denise: Mary Jo Smith. Sheri/Amy: Nike Doukas. Mike: Kevin Kilner.
Guest Cast
Denise Moses Denise Moses Larinda
Mary Jo Smith Mary Jo Smith Denise
Nike Doukas Nike Doukas Sheri/Amy
Cast & Details See all »
- Rating: None
- Premise: A romantic comedy about two L.A. workaholics (a TV producer and a district attorney) who try to find time for a relationship while dealing with the demands of their careers. At the start of Year 2, the couple broke up. But the show, too, was just about fin… (more)
Trending TonightSee all »
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Watch This
Mr. Robot: Is Tyrell hunting down fsociety?
The Almost Perfect Bank Robbery
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text:
|Message view
|« Date » · « Thread »
|« Date » · « Thread »
|Eric Evans <eev...@rackspace.com>
|Re: Release Manager Volunteers?
|Thu, 14 Apr 2011 13:54:47 GMT
(You don't need to Cc me, I am subscribed) On Thu, 2011-04-14 at 08:56 +0100, Stephen Connolly wrote: > Why should you limit to just one volunteer? I wouldn't; I didn't. > The idea is that the procedure in > http://wiki.apache.org/cassandra/HowToPublishReleases should be > followable by any Cassandra committer. > > I would propose that the release manager is the person who steps up to > run the release for that specific release. If it is just one person > always making releases then that becomes a SPOF... better to have more > than one and round-robin it, or have one do the stable releases and > the other do the new releases... That's a good idea, we can start round-robining between Sylvain and Sylvain right away! :) -- Eric Evans email@example.com
|View raw message


text:
Utah Jazz vs. Los Angeles Clippers in Weekend Game
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for Utah Jazz vs. Los Angeles Clippers was Sunday November 28, 2010 / 12:30pm.
Currently at STAPLES Center
Barbra Live: The Music ... The Mem'ries ... The Magic!
- Full Price:
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There just aren't enough superlatives in the universe to describe the iconic entertainer simply… More
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Featured review from BruinD
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Great seats at Staples! Sitting in the Premier section seats where you can order from the friendly staff and have the food delivered to you is a great way to see an event without the added stress of standing extra lines. As for the Clippers ... well, they have some decent players, and Blake Griffin is a beast, but they are a work in progress. The first half was well played by both teams, then the Clips fell apart in the second. So while I had fun, it would have been nicer to see the Clippers win ... and score more than 12 points in the 3rd quarter.
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Had a great time!
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We took our guests from out of town. Seats were great. Everyone had a really good time! Great way to close out the holiday weekend, even though the Clippers lost.
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Game was good and the seat was great. Thank you!!!


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Join Date: Oct 2003
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Originally Posted by ahwuko
No eye contact with me, no hello, no acknowledgment at all that he was in a social situation. SCARY!
Originally Posted by Mrs Dimples
Oh goody, I to get riled up. Thanks for the recommendation, maybe next I can learn to read while nursing!
|BTW - if you "really want to go into labor in your own", and you're not even 39 weeks...YOU CAN JUST WAIT! : Being induced at 39 weeks and saying that you "just didn't go into labor on your own" is absolutely ridiculous and you know it!!!!
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