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How Do Anticancer Drugs Work?
In free public lecture on May 16 at UC Riverside chemist Yinsheng Wang will discuss implications of personalized medicine in cancer treatment and explain how drugs induce damage to DNA
RIVERSIDE, Calif. — Anticancer drugs save lives and/or improve the quality of life for many cancer patients. Many anti-cancer drugs work by killing tumor cells after inducing damage to DNA.
The public has an opportunity to learn about the mechanisms of action of some commonly used anticancer drugs and how laboratory research may lead to novel targets and new strategies for cancer treatment.
Yinsheng Wang, a professor of chemistry at the University of California, Riverside, will give a free lecture on May 16 on campus to discuss those drugs that induce damage to DNA, as well as those biomolecules that allow for selective targeting of tumor cells. He will also discuss the implications of personalized medicine in cancer treatment.
Wang's hour-long talk is titled "Curing cancer: How do anticancer drugs work?" It will begin at 5:30 p.m. in Rooms C, D and E, University Extension Center (UNEX). Seating is open. Parking at UNEX is free for lecture attendees.
The lecture is the third in the annual Science Lecture Series hosted by the College of Natural and Agricultural Sciences (CNAS). This year the theme is "The Science of Disease." The series aims to boost the public's awareness and understanding of science and of how scientists work.
"Anti-cancer drugs induce their cytotoxic effects via different molecular targets," Wang said. "Patients' genetic make-up can have a significant effect on the clinical efficacies of anti-tumor drugs. Innovative technologies may lead to the discovery of new molecular targets that can be used for more effective treatment of cancer while minimizing side effects."
Wang is the director of the Environmental Toxicology Graduate Program at UC Riverside. He received his bachelor's degree from Shandong University and master's degree from the Chinese Academy of Sciences. He joined the UCR faculty in 2001, after earning his doctoral degree from Washington University in St. Louis.
He is the recipient of the 2013 Biemann Medal and a 2005 Research Award from the American Society for Mass Spectrometry, as well as the inaugural Chemical Research in Toxicology Young Investigator Award from the American Chemical Society in 2012. He was named a Fellow of the American Association for the Advancement of Science in 2012.
Research in the Wang group is concentrated in two broad areas. The first is DNA damage and repair. His lab uses a variety of chemical and biological tools to understand, at the molecular level, how various kinds of damage to DNA are repaired, and how they affect the flow of genetic information during DNA replication and transcription. His work has brought scientists' understanding of the biological consequences of DNA damage to a new level.
His lab's second research area is proteomics, the study of the functions, structures, and interactions of proteins. His work in this area has led to the discovery of novel mechanisms of action of some anti-tumor drugs and environmental toxicants. In particular, he seeks to understand alterations in the expression of proteins in cells that are treated with anticancer drugs and other agents.
Wang's lecture will be introduced by Aurora Johnson, a physical science teacher in the Moreno Valley Unified School District with 11 years of teaching experience. Previously, she worked in the Riverside and Palm Springs Unified School Districts. She was educated at Riverside City College, Grand Canyon University, and UCR.
More information about the lecture series can be obtained by visiting www.cnas.ucr.edu, calling (951) 827-6555 or emailing Carol Lerner.
Teachers interested in receiving professional development credit for attending the lecture series must make arrangements in advance with University Extension [email@example.com; (951) 827-1653].
Media Contact
Iqbal Pittalwala
Tel: (951) 827-6050
E-mail: firstname.lastname@example.com
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Archived under: Health, Inside UCR, Science/Technology, anticancer, cancer, Department of Chemistry, drugs, press release, public lecture, science lecture series, Yinsheng Wang
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Samantha Little, head of Russell-Cooke's Children Department, has been nominated for a Legal Aid Lawyer of the Year award in the Family category. Finalists for the awards, which are organised by The Legal Aid Practitioners Group, were selected by a panel chaired by Cherie Booth QC and judges included Polly Toynbee of the Guardian and Doreen Lawrence of the Stephen Lawrence Trust. The winners will be announced at a ceremony on 1st December 2008.
Samantha has long been recognised as one of the country's leading lawyers for public law children work and is described in Chambers Guide to the Legal Profession as "totally dedicated to her clients". She is a member of the Law Society's Children Panel and the Association of Lawyers for Children. She's also an active member of Resolution and works with both the Children and Skills committees.

subset: commoncrawl


text:
|The good bishop knew very well that everyone in his small town look to him for an example. One night, however, after a long, hard day, he came to his last visitation.
His hostess, noting that he looked tired, asked with concern, "A spot of tea, Bishop?"
"No, thank you," he managed. "No tea."
"Ah," she said. "Coffee, then?"
"No coffee either, thank you."
In the spirit of intrigue, she leaned closer and murmured, "I could bring you a scotch and soda in a dark mug?"
"My dear, this is my last word, "NO soda."
|Santa Apni Problem Leke Doctor Ke Pass Gaya Aur Bola: Doctor Sahab, Jab Bhi Main Seedha Khada Rah Kar... Halka Sa Jhuk Kar Apni Left Leg Ghutne Se Modkar Seedha Karta Hoon... Phir Right Leg Ko Ghutne Se Modkar Seedha Karta Hoon Tab Kamar Mein Dard Hota Hai.
Doctor, Hairani Se: Abe Agar Aisa Karne Se Dard Hota Hai Toh Tu Aisa Drama Karta Hi Kyun Hai?
Santa, Badi Hi Masoomiyat Se: Toh Kya Main Ab Underwear Bhi Na Pahnu?
|As Air Force One arrives at the Heathrow Airport, President Obama strides to a warm and dignified reception from the Queen.
They are driven in a 1934 Bentley to the edge of central London, where they change to a magnificent 17th century carriage hitched to six white horses. They continue on towards the Buckingham Palace, waving to the thousands of cheering Britons; all is going well.
Suddenly, the right rear horse lets out the most horrendous earth shattering fart ever heard in the British Empire. The smell is so atrocious that both the passengers in the carriage, must use handkerchiefs over their noses. The fart shakes the coach, but, the two dignitaries of State do their best to ignore the incident.
The Queen politely turns to President Obama, "Mr President, please, accept my regrets...I am sure you understand there are some things that even a Queen cannot control."
Obama, always trying to be "Presidential," responded, "Your Majesty, do not give the matter another thought... Until you mentioned it, I thought it was one of the horses."
|Newton's third law states:
Every action has an equal and an opposite reaction.
So it would stand to reason that every proverb has an equal and opposite proverb.
Actions speak louder than words.
The pen is mightier than the sword.
Look before you leap.
He who hesitates is lost.
Many hands make light work.
Too many cooks spoil the broth.
Clothes make the man.
Don't judge a book by its cover.
Nothing ventured, nothing gained.
Better safe than sorry.
The bigger, the better.
The best things come in small packages.
Absence makes the heart grow fonder.
Out of sight, out of mind.
What will be, will be.
Life is what you make it.
Cross your bridges when you come to them.
Forewarned is forearmed.
What's good for the goose is good for the gander.
One man's meat is another man's poison.
With age comes wisdom.
Out of the mouths of babes come all wise sayings.
The more, the merrier.
Two's company; three's a crowd.


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The first birthday Smash Cake
By TheGamingAngel on January 16, 2014
BlogHer Network
I can't believe it's already been a year. One year ago, we went to the hospital and after many hours and an intense birth experience, we had Pumpkin at 8:39pm on January 16, 2013. Our lives were forever changed at that point. . . .
Read more from The first birthday Smash Cake at TheGamingAngel
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Top Definition
The feeling of foamy stuff in the back of your thoat after you smoked a whole lot of bomb.
Nigggguh I got clobber of slobber can you pass me a some that drank.
de flossinboss 09 Decembrie 2010
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E-mailurile sunt trimise de la email@example.com. Nu-ți vom trimite mesaje nedorite.×


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Yao On Trial at West Ham
Saturday, 24th Jul 2010 17:41
Former Town midfielder Devann Yao is on trial with West Ham and scored a goal as a Hammers XI lost 4-2 to League Two Burton Albion at the Pirelli Stadium this afternoon. The American was released by Town at the end of the season.
The 20-year-old wideman netted his goal just before half-time, curling the ball into the net from 16 yards.
The New Yorker, who was previously with Metz, Pisa, Livorno and St Mirren, spent a long spell on trial with the Blues late last year, winning himself a contract until the end of the season. However, the Yao failed to impress in Town's reserves and was let go in May without making a senior appearance.
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Luck, Truth, Girls in Portugal by Mullet
Football is obviously a global game and these days that concept is more keenly emphasised in no other place like England, with the Premier League as vast and cosmopolitan as the Roman Empire, while the national side flounders like ball-playing barbarians.
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As some of you may know, on 1st April 2012, me and my partner Becky lost our beautiful son, Tyler. He was only 15 months old when he passed away peacefully in his sleep. Later that year, we began fundraising for a brilliant charity, The Lullaby Trust (formerly known as FSID).
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Manchin Thanks Rockefeller for Years of Service
Friday, January 11, 2013 - 18:57 Updated 3 years ago Provided from a Sen. Joe Manchin Release
"When I first arrived in Washington two and a half years ago, I couldn't have received a warmer welcome from Jay and his staff, and I am so personally grateful for all their help. More importantly, in all his decades of public service, Jay has followed one guiding principle: to improve the lives of West Virginians. Jay's heart has always been true, and we share the goal of serving the beautiful people of the state we love today and into the future."//


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The only 100% Free Online Dating site for dating, love, relationships and friendship. Register
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United in Song
Kudos to the United Nations Association International Choir for such a straightforward title for their spring concert. "Out of Africa and Beyond" features dancers, percussionists and singers from Kuumba House Dance Theatre performing songs and dances from African countries such as Kenya, KwaZulu-Natal, the Democratic Republic of the Congo and Nigeria. Plus, there are some African-American and Jamaican tunes, and a folk song in Ladino, the ancient language of the Sephardic Jews of Spain. Sounds "beyond" to us.
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Watch: Harshvardhan Kapoor and Saiyami Kher's Mirzya trailerAfter releasing an intriguing teaser of 'Mirzya',Rakyesh Omprakash Mehra has unveiledthe films' trailer. The filmmarks the debut of Anil Kapoor's son, Harshvardhan Kapoor, and Tanvi Azmi's niece Saiyami Kher. The story which is inspired by the ... Deccan Chronicle, 1 month ago
Here's What Anil Kapoor Has to Say about His Son Harshvardhan's Mirzya - Pink Villa, 1 month ago
3 images for "rakyesh omprakash mehra"
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The controversy surrounding Udta Punjab is never-ending. After Bollywood came out in full force to support the film at a press conference on Wednesday— Mukesh and Mahesh Bhatt, Satish Kaushik, Imitiaz Ali, Zoya Akhtar, Anurag Kashyap, Ashoke ...Firstpost.com, 1 month ago
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In a scenario where most Bollywood stylistic experimentations appear synthesised from a cookie cutter format, stylist Leepakshi Ellawadi swears by her own unique ethos. The lady behind Anushka Sharma's spunky and devil-may-care look in Sultan likes ...DNA India, 1 month ago
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New for iPad 2: Griffin, Speck, Orbino, XGear, more
New cases and accessories for the iPad 2 are continuing to roll in from manufacturers. Griffin has announced updated versions of its Elan Folio Slim textured polyurethane folio case ($40) and CinemaSeat headrest adapter/case ($40) for the iPad 2, along with new colors of its Sylus for iPad ($20). Speck has introduced its iGuy case for the iPad and iPad 2 ($40), a revised version of its iconic case for the original iPad that debuted at the 2011 CES, and its new PixelSkin HD Wrap case for iPad 2 ($50), featuring an integrated cover/stand.
Orbino has unveiled its new Padova II case for the iPad 2 ($209 and up), offering integrated magnets compatible with the iPad 2's Smart Cover technology, while XGear is offering its 360 Shield Polycarbonate Swivel Case ($40) and 360 Shield Case ($100) for the iPad 2, the latter made from real carbon fiber. Finally, Hub International has announced that a revised version of its HandStand case ($50) will be available for the iPad 2 in the next two months.
Griffin Elan Folio Slim
Griffin CinemaSeat2
Griffin Stylus Brights and Naturals
Speck PixelSkin HD Wrap
Orbino Padova II
XGear 360 Shield Polycarbonate Swivel Case
XGear 360 Shield Case
HandStand Case
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I get the impression that the iPad 2's magnet system caught the iDevice accessory makers flat-footed. There are precious few cases fitted specifically for the iPad 2, only one with a sleep/wake magnet (Orbino), and non that attach magnetically. Did Apple withhold the "real" iPad design details for too long?
Posted by Farnsworth on March 16, 2011 at 10:06 AM (CDT)
I was so excited to get the 360 Shield case. After approx 2 weeks the plastic tab to hold in the iPad broke. I never removed the iPad once placed in the case so this was very upsetting. The manufacturer replaced the case without question. I've had my replacement case for 3 weeks and the exact same thing happen, the tab broke again. There must be a design flaw in the case because I take extra special care of my iPad and the accessories. I've decided not to contact the manufacturer for another replacement. I will need to find another case.
Posted by JMcIntosh on October 23, 2011 at 9:34 PM (CDT)
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Easy access from the motorway.
No character, no atmosphere, very much a quick overnight stopover, up&away place.
excellent hotel
We have stayed here twice now, en route to Italy. The hotel is not far from the motorway but feels remote in a pretty mountain village. The staff are always charming and anxious to please.
Great service, great views, and some of the best food we've ever had! After an epic day cycling through some high passes in freezing blizzards, this guest house was a godsend. Seriously, the restaurant was superb with great views of the mountains, and subtle flavours that are difficult to find these days. Delicious! We took the spa room, and though it didn't have a view it was clean and comfortable with a nice big jacuzzi that wasn't too noisy in its operation, and very soothing on our tired legs. The buffet breakfast was a simple continental affair with several types of bread, cereal, fruit, cold meats and cheese, and boiled eggs. All in all a beautiful little guest house with the restaurant being the highlight.
Very close to train station, but room was not noisy. Large size room and bathroom.
Staff have limited or no English
Ideal location at bottom of Gotthard Pass. Directly opposite the station.
Hotel was a bit utilitarian and with laminate floors throughout was very noisy. The disco attached to the hotel played loud music that reverberated through the room until 3am. Inconsiderate and noisy guests returning to rooms after the disco kept us awake until 4am.
very good location near St. Gottardo Tunnel. Warm room with excellent shower. Ok breakfast with fresh bread (sunday morning) and possible to have breakfast from 7.30pm
Had to pay with cash. Credit card not excepted. Fortunately we had the euros. also did not like that Hotel waas removed from bookings.com website which neccesitated a telephone call to ensure booking was secure.
Very friendly stuff. Comfortable beds.
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The food is very good and the prices reasonable. Comfortable and elegant. Jeans are o.k. but this is a first class operation.
This is my go-to place for take-out. Bangkok 54 is the best Thai food in the Arlington area. The Panang Chicken is my dish of choice. The menu has a good variety and is priced reasonably. You can eat in the dining room or get take out.
I love their chicken curry with butternut squash. We went with a party of 13 and everyone was satisfied with their choices. You can see that the management of this place is strong and keeps a close eye on the quality of the food. We'll be back.
We went here based on the Washingtonian list of Cheap Eats. We ordered Green papaya salad for a shared appetizer--wow! Looking at the menu online now, I can see that most appetizers have chili sauce, or chili powder as an ingredient, but none have a little chili spicy icon, like some restaurants provide. This was a five minute burn--unpleasant! Yikes! When we told our waitress that it was too spicy, she seemed mildly amused--we were not! Finally when she came back and noticed that we were soaking our tongues in our water glasses just to delay the spicy burn, she offered, "sorry." This is a service failure on her part and for the restaurant. She could have casually mentioned that this dish was very spicy, and/or told the preparer to go easy on the chili. After the fire went out, we ordered red curry shrimp with butternut squash (with the spoken understanding that she could make it "not spicy." We also ordered a whole fish--they offer several kinds, each with a different price that our waitress couldn't quote without checking with the manager. Both dishes were very good--the whole flounder with a sweet & sour sauce on the side was very nice. So, I guess you get the drift--beware of the five-alarm chili, and, well, beware of what seems to be a service problem.BTW, I gave this place a 4, because the food is very good, and we will probably go back some time.
Recently moved from Tysons to Arlington and have eaten here multiple times in the last few weeks due to lack of food in the house. The food is incredible, and consistently good. Traditional dishes such as the Drunken Noodle are absolutely perfect, whether you choose the spicy or non-spicy version. Portion sizes are robust.Their seasonal dishes are great too. Currently, they have a squash (and chicken) red curry dish that is out of this world.In some cases, I recommend dining in; as an example, the curry dish mentioned above comes with a salad but only when dining in.
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text:
He has a special interest in joint replacement surgery and minimally invasive surgery for hip and knee arthritis. Dr. Lorei earned his medical degree at the University of Pennsylvania School of Medicine in Philadelphia and completed an orthopedic surgery residency at Lenox Hill Hospital in New York City. His additional training includes a joint reconstruction fellowship at Hospital for Special Surgery in New York City.
Dr. Lorei is a member of the American Academy of Orthopaedic Surgeons and previously held appointments at Cornell University Medical College in Ithaca, N.Y., and Thomas Jefferson University in Philadelphia.
Related Articles on Physician Moves:
Dr. John Gillen Joins New Century Orthopedics of Pittsburgh
Dr. Fazel Khan Becomes Assistant Professor of Orthopedics at Stony Brook University
Orthopedic Trauma Specialist Dr. Sundeep Taksali Joins Hope Orthopedics in December
Temple University Hospital Names Dr. Matthew Lorei Assistant Director of Joint Replacement & ReconstructionWritten by Laura Dyrda | Friday, 27 January 2012 16:38
Matthew P. Lorei, MD, an orthopedic surgeon, recently joined Temple University School of Medicine as an associate professor of orthopedic surgery and assistant director of joint replacement and reconstruction surgery at Temple University Hospital in Philadelphia, according to a hospital news release.
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text:
New Delhi: An assistant commissioner (ACP) of Delhi Police was Friday suspended for slapping a 17-year-old girl protester, who was trying to meet the five-year-old rape victim at a hospital here.
ACP Bani Singh Ahlawat, posted at Khajuri Khas area of east Delhi, was suspended with immediate effect for slapping and pushing Beenu Rawat, a class 12 student, said a senior police officer.
Rawat, a resident of east Delhi`s Shahdara, was trying to enter the emergency ward of the Swami Dayanand hospital when she was assaulted by the ACP.
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Today's Devotional
Tongues AfireWhen have you recently endured the wound of another person's words?
Let's Make ItFacebook official!
SUPERNATURAL Power of God
Embed ribbons-the-clown-tv 3306 views 2010-10-01T22:40:34 Supernatural power of God is for you today to<br />
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"Come Now is the time to worship"


text: Not that I'm a vegetarian it's just an outstanding pizza. I always order without the green peppers. I sure wish restaurants would start using the other pepper colors, red, yellow and orange are so much better. There is lots of cheese on the pizza and I always feel like I'm getting such a better value than the franchises.


text:
Utah Utes basketball: Technicality allows other schools to talk to Sharp
SALT LAKE CITY — Utah coach Larry Krystkowiak has made it clear. He would like to have returning LDS Church missionary Josh Sharp on the team next season when the Utes move into the Pac-12.
However, due to a paperwork technicality, the former Lone Peak High School star could end up elsewhere.
The university announced Friday that other schools are allowed to contact Sharp, who redshirted in 2008-09 before leaving on a mission to Texas, because he did not sign his National Letter of Intent and financial aid agreement with Utah simultaneously.
The 6-foot-7, 185-pound forward signed his NLI with the Utes and former coach Jim Boylen on Nov. 14, 2007, but didn't sign his financial aid agreement until the following January. Binding agreements require that both be done at the same time.
"We want Josh to be a part of our program and are disappointed that rival schools can take advantage of a loophole in the system should they choose," Krystkowiak said in a released statement. "Josh attended classes here for a year, signed an NLI and financial aid agreement, and we want him to continue his education and playing career here."
The new coaching staff, which has recruited seven new players to the program since Krystkowiak replaced the fired Boylen last month, planned on Sharp filling one of the program's 13 scholarship slots (the only in-state player in the group) for 2011-12.
Sharp, reportedly, may be interested in signing with BYU or Utah State instead.
Mutual interest, though, has yet to be verified.
"It is my understanding that there is an unwritten rule that players cannot be recruited by other schools while they are serving missions. To do so is not only inappropriate, but it creates an atmosphere of ill will," Krystkowiak continued. "We hope that Josh returns to our team and wants to be part of what we are building here, but regardless of what happens, we remain strongly committed to recruiting the best players in the state of Utah."
Sharp averaged 13.5 points and 6.3 rebounds as a senior at Lone Peak. He earned first-team all-state honors from the Deseret News after helping the Knights win back-to-back state championships.
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Movies that are slightly off.
Electra Glide in Blue
1973 Directed by James William Guercio
He's A Good Cop. On A Big Bike. On A Bad Road.
A short Arizona motorcycle cop gets his wish and is promoted to Homicide following the mysterious murder of a hermit. He is forced to confront his illusions about himself and those around him in order to solve the case, eventually returning to solitude in the desert.
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You don't get many films like Electra Glide In Blue any more.
I know that's such an easy thing to say about an old(er) film in a sub-genre that generally doesn't get much coverage these days because the natural progression of the medium of filmmaking and society as a whole has shifted the cop crime drama in a different direction. But it's true!
What is that sub-genre? I'm not really sure it has a name so I'm going to call it 'Dusty Desert Crime And Road Movies'. There were loads of them in the 1970s, where the dust and the ever-beating sun and the endless straight roads played every bit as much a part in certain films as the plot…
Electra Glide in Blue is strangle little movie that seems to exist in some kind of odd hazy dream world where John Ford and Dirty Harry live together in not so perfect harmony. The film can't decide if it wants to be the anti Easy Rider or a straight out action/mystery film and the two personalities seem constantly at clash. Robert Blake makes for an interesting action star/leading man in this and it is a very well shot film and while it never stopped being interesting, it just never clicked for me the way i wanted it to.
I have always thought that your enjoyment of Electra Glide in Blue could be summed up with whether you find jokes about Robert Blake being short funny. Personally, I think all of the height jokes are amusing, which gives the first hour of the film are really cool sense of humour. However, as the film gets more serious, more out-there and becomes the one-of-a-kind cult it is known to be, it really steps up a level, from the darkly amusing the evidently brilliant.
Electra Glide in Blue plays with the John Ford iconography, stunningly shot by Conrad Hall, with a real sense of foreboding. It is an inverse of Easy Rider, but equally about the American dream, the film is…
Apparently, this is one of those one-and-done directorial efforts that leaves audiences wanting more and wondering what other gems we've missed out on. But this certainly feels like a film where a lot of really different elements came together, so Guercio doesn't deserve all the credit. That would be a disservice to legendary cinematographer Conrad Hall and some of the cast.
As a story, it's actually far more interesting and nuanced than Easy Rider, to which it will always unavoidably be compared. I also really liked Blake's character. We first see him as a flashy meat-head with a floozie girlfriend but, as the film goes on, we find that he's actually very independent-minded and kind. The rest of the characters…
My Dad's favourite film! And since this was the only context in which I'd ever heard it spoken of, I was not expecting much to be honest (he is not the most solid source of cinematic recommendations…). But it's actually pretty good! I found it to have a very distinctive flavour. I especially enjoyed the opening act. The introduction of our hero, a diminutive Arizonan motorcycle cop named Wintergreen with dreams of the big leagues, is a lot of fun - various pans around his apartment as he lifts dumbbells while doing absolutely everything, including drinking raw eggs! - and gives us some quick insight into his psychological makeup. Watching this driven character bomb around the desert roads, trading jibes…
The only film ever directed by James William Guerico ELECTRA GLIDE IN BLUE has naturally become something of a cult movie. It's a rambling, virtually plotless picture about a motorcycle cop, Robert Blake, roaming the vast expanses of Arizona imagining himself as some kind of white knight on a motorized steed. As we say back here in Ireland, he doesn't always come over as the full shilling. He's permanently spaced out on nothing but the vibes he radiates from himself, continually self-conscious about his height, (he claims he is exactly the same height as Alan Ladd was down to the nearest quarter inch).
Guerico, who also produced the film, was something of a jack-of-all-trades and his film alludes to the…
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My Dad's favourite film! And since this was the only context in which I'd ever heard it spoken of, I was not expecting much to be honest (he is not the most solid source of cinematic recommendations…). But it's actually pretty good! I found it to have a very distinctive flavour. I especially enjoyed the opening act. The introduction of our hero, a diminutive Arizonan motorcycle cop named Wintergreen with dreams of the big leagues, is a lot of fun - various pans around his apartment as he lifts dumbbells while doing absolutely everything, including drinking raw eggs! - and gives us some quick insight into his psychological makeup. Watching this driven character bomb around the desert roads, trading jibes…
"Incompetence is the worst form of corruption."
Perhaps not as thrilling as 'Vanishing Point' but just as thematic and lush, 'Electra Glide in Blue' features Robert Forster as a relentlessly idealistic cop fighting against the forces that pervade the early 1970's American Southwest: renegade cops, dirty hippies, bikers, hermits, cults, and drug dealers. I nearly lost by shit Mitchell Ryan stepped into frame in a slick cowboy suit, and this clearly had a lot to do with future cop films like the Coen's 'Blood Simple'. Beautifully taking advantage of the desert landscape, this films is easily among by favorite 1970's road films.
Outro filme idiossincrático de um diretor de um filme só. Uma belíssima abertura e um diálogo interessante com o que se fazia à época, em especial os filmes de Monte Hellman.
Hate the ending. Absolutely hate it. That last shot is excellent regardless. Hell - Conrad Hall's work on this is some of the best cinematography I've ever seen captured. Great and absorbing script with solid performances all around. Definitely needed more Jeannine Riley, and right about the time the movie sags, she jolts it back to life. Great stuff, tho.
Electra Glide in Blue is very much of its time - unwashed hippies, drugs, motorcycles, fascist cops, a psychedelic rock concert and a murder all out in the desert somewhere.
I couldn't really find a way in, or back or whatever - just ... nothing really.
"Isn't it funny how people do all kinda things and most of it's just a lotta bullshit."
Downbeat 70s cops vs. hippies movie, at least, that's how it's usually sold. It's downbeat, but it's politically fairly evenhanded. Robert Blake is very good. I wish the murder mystery angle had been handled better.
"I'm moved to work you over. I'm moved to bust your kidneys. And I won't leave a trace, not a mark on you. You hear what I'm saying to you. I'll work you over till you wish you died last week."
A somewhat opposing thesis to 1969's Easy Rider, Electra Glide in Blue suggests that we are all on our own, with both main culture and counter culture not providing a proper home for the individual trying to play the game by following the rules. Easy Rider is already a pretty cynical film, but I think that Electra Glide in Blue out cynicals it, and I love it for that.
It's a tale of what is ultimately the death of dreams for a short but ambitious Arizona motorcycle cop, who must face the illusions about himself and those around him following a sudden promotion to homicide. Robert Blake excels are the lead protagonist, embodying a sense honestly and decency which sets him apart from an aura of cynicism which plagued much of American society during the mid 70s. Exciting and at times insightful, this is one film not to be underestimated.
Some really excellent parts, a superb central performance and lots of leather and motorcycle fetishizing
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Making good photos is a pleasure. To continue making them will be a gift. Equipment is to make the photos memorable. Mostly, I have no excuses. The equipment is the best. I continue to work on the operator. Been at it since 1948. There are signs of improvment from time to time.
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JASC renames file type?
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janeenadamsmartin • Contributing Member • Posts: 648
JASC renames file type?
Mar 14, 2005
I bought a new computer, downloading my D70 pics, viewed them with JASC PSP Studio software (free on computer), and two things happened:
1. now all the file types for these images have been changed to "JASC Studio" file type. I want them to return to .jpg file types.
2. for the photos I modified, it looks like PSP overwrote the EXIF data and replaced it with the date I modified it and lost the date the pic was taken.
How do I get the file type to revert back to .jpg? I figure I lost the EXIF data and just have to accept that.
Thanks in advance,
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Live Through This Hardcover – October 2, 2012
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Because Live Through This is an important and upsetting book. Sexual abuse is something that happens entirely too often, and the way Mindi Scott tells Coley's story is just...perfect. We have moments where we're giddy with Coley over the dorky and cute Reese, or we're laughing with Coley and her best friend Noah (who I love to death, FYI), but there's also this heavy feeling while reading Live Through This that we realize Coley must feel all the time because of what's happening to her.
I was so tense while reading Live Through This - I loved the way Mindi Scott kept the identity of Coley's abuser under wraps for a bit. I was tense and nervous and accusatory and my heart just broke when everything was revealed.
It's really hard for me to write a full review of Live Through This. Mindi Scott delivers a heart wrenching book that made me laugh and cry and want to curl up under the bed and hide from everyone. Live Through This is a beautiful contemporary that portrays an issue that ought to be brought to light more often.
Then it shifts to a brave, tense start.
By the end of the first scene, it becomes clear that Coley is not a sexually-active, sexually-confident teenager; she's being sexually abused by a family member and putting a lot of her youthful energy into coping.
It's a strong hook. From here, Coley willfully carries on with her normal teenage life. Her struggles include dance team competition, best friend conflicts, and that potential boyfriend.
However, the abuse looms in the background. The reader wonders, at first, who in the family is the real threat, and shares Coley's sublimated fear throughout. The abuse is bound to happen again. Coley tries to juggle situations in her favor, but she's endangered in her home.
This, the author's second novel, shares the strengths of Freefall: a strong teen voice with romance and humor. The fun parts and everyday drama of being a teen are captured here, too.
The novel follows Coley's journey with a strong finish, but stops short of offering a pat conclusion. It's well told.
I was weeping at the end and wishing I'd read more books like this in high school.
Writers, read this for: a strong hook, tight scenes, sustaining tension -- smart choices on what to leave in and leave out.
Full disclosure: I took a writing certificate program with Mindi Scott at the University of Washington and was in a writing group (affectionately called "Pam's Kids," after our instructor Pam Binder) with her for a while.Read more ›
Coley has what looks to be the perfect life. Her family is a bit loud, and they get on each other's nerves sometimes, but they look happy. She's on the dance team and is great at it. She's got the perfect friends-to-more relationship that people envy.
What people don't see is how messed up her home life is, how her best friend no longer speaks to her, her dance team is filled with tension, and she has no idea how to try and take control as her life spins out from under her.
Coley and Reece started as friends, and as they start a more romantic relationship, the other strings of her life start to unwind. She doesn't know how to keep Reece and deal with what's wrong in her life.
The pace of the novel is quite fast, but it works. Scott starts the novel right away and doesn't make you guess what's going to happen. She dealt with an extremely tough subject delicately, but she didn't gloss over things. She laid it all out there and that's why the ending felt off to me.
I don't want to give any spoilers, but the ending felt too abrupt and left a few too many things in the air for my taste. I don't mind using my own imagination to come up with how the story continues, but there was too much left unanswered for me with this ending. Just a little bit more, covering the conversation she was about to have, would have felt like a better fitting ending.
Live Through This is a mature novel that handles the topic of sexual abuse as best as a book can. I didn't feel as connected with the characters as I would have liked, and the ending didn't feel like quite enough, but it is still a good book.
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I went into this book knowing the subject matter, but needing an example of how an author handled sexual abuse via a family member. Read morePublished 1 month ago by wendyj
Didn't think I would love this as much as I did. A survivor story with plenty romance, cuteness, and sad, realistic bits.Published 1 month ago by Amazon Customer
I remember reading about this on a few blogs and dying to get my hands on it. The premise sounded great and like something I would really enjoy. Read morePublished on May 19, 2014 by C. Conant
I really liked this book. Coley is barely coping with life while trying to hide a deep dark secret. The facade starts to crack as her relationship with Reece develops and layer by... Read morePublished on February 13, 2014 by Sue Holmes @Crushingcinders
Live Through This has been on my TBR for a while now... since before it was released actually. I didn't hesitate when I seen this at the library, I knew I had to pick it up and... Read morePublished on July 1, 2013 by Lauren
I really wanted to love this book. And I did like it a lot. But the ending kind of ruined everything for me.
Coley is having problems. Read more
Yikes, this book isn't my typical read. I had a hard time understanding the first two chapters. It starts off with the main character being abused I guess by her brother.Published on April 30, 2013 by Lorna
I wasn't really sure what to expect from this book, I was told from a friend to read it. I don't want to give anything away so I will just say it had your emotions running on high... Read morePublished on April 14, 2013 by Laselle


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1.2 Million Signatures Call For Stanford Sex Assault Judge's RecallActivists are set to submit a petition on Monday with 1.2 million signatures calling for the recall of Santa Clara County Superior Court Judge Aaron Persky.
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266 Crashes Linked To Confusing Shifters Like One Found In Jeep That Crushed Star Trek Actor, NHTSA FindsA government investigation into confusing gear shifters like the one in the SUV that crushed and killed Star Trek actor Anton Yelchin found 266 crashes that injured 68 people.
Ikea Recalls 29 Million Dressers After 6 Children Killed, Dozens InjuredIkea is recalling 29 million chests and dressers that can easily tip over and trap children underneath.
Hollywood Star's Death Speeds Up Jeep RecallFiat Chrysler is speeding up a recall of 1.1 million vehicles with confusing gear shifters like one in the SUV that crushed and killed Star Trek actor Anton Yelchin.
Infiniti Recalls SUVs To Fix Electronic Steering ProblemNissan is recalling 60,000 Infiniti luxury SUVs worldwide because the electronic steering can malfunction.
SUV That Killed 'Star Trek' Actor Was Recalled Due To Confusing Gear ShiftersThe SUV that rolled down a driveway and killed "Star Trek" actor Anton Yelchin was being recalled because the gear shifters have confused drivers, causing the vehicles to roll away unexpectedly, government records show.
Retired California Judge Says Brock Turner's Light Sentence Result Of 'White Privilege'A retired California judge says Stanford University sex assailant Brock Turner's light jail sentence was a result of "white privilege".


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A New Spin On The Classics
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Monitor data files, data integrity and data security. Develop and support disaster recovery and business continuity of critical business data....
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Collect and analyze data to validate and support informed business decisions. Assists business leaders in developing tactical and strategic programs to support...


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Geronimus says black-white differences in mortality "help silence black voices in the electorate"
Do universities need more conservative thinkers?
Starr critical of risk assessment scores for sentencing
Frey's new report explores how the changing US electorate could shape the next 5 presidential elections, 2016 to 2032
U-M's Data Science Initiative offers expanded consulting services via CSCAR
Elizabeth Bruch promoted to Associate Professor
Susan Murphy elected to the National Academy of Sciences
PSC Brown Bags
will resume fall 2016
Educational Spillovers and Adult Health in the United States (PSC Initiatives)
Assistant Professor, Mississippi State University.
Ph.D., University of Texas at Austin
Dr. Brown's research broadly examines how socioeconomic status and social relationships influence population health. His recent research has examined educational differences in older adult mortality compression, the combined influence of education and marital status on older adult mortality, the relationship between marital biography and cumulative biological risk, and health differences between individuals in same-sex and different-sex relationships. His current research investigates various ways that educational attainment and marriage provide individuals with the material and non-material resources necessary to avoid health risks and accumulate health advantages over the course of their lives.
Verbrugge, Lois M., Dustin Brown, and Anna Zajacova. Forthcoming. "Disability Rises Gradually for a Cohort of Older Americans." Journals of Gerontology B: Psychological and Social Sciences. DOI. Abstract.
Angel, J., S. Rote, Dustin Brown, R. Angel, and K. Markides. 2014. "Nativity Status and Sources of Care Assistance Among Elderly Mexican-Origin Adults." Journal of Cross-Cultural Gerontology, 29(3): 243-258. DOI. Abstract.
Reczek, C., Haoming Liu, and Dustin Brown. 2014. "Cigarette Smoking in Same-Sex and Different-Sex Unions: The Role of Socioeconomic and Psychological Factors." Population Research and Policy Review, 33(4): 527-551. PMCID: PMC4204629. DOI. Abstract.
Brown, Dustin, Robert A. Hummer, and Mark D. Hayward. 2014. "The Importance of Spousal Education for the Self-Rated Health of Married Adults in the United States." Population Research and Policy Review, 33(1): 127-151. PMCID: PMC3912877. DOI. Abstract.


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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Representing the latest in modularity, efficiency, stability, silence and green innovation, the SeaSonic M12 SS-700HM redefines "high-end modular PSU". Packed with impressive features, this 700 Watt power supply is ideal for your high end gaming system needs. Dual Magnetic Amplifiers (Mag-Amp) improve cross regulation tolerance on +12V lines and increase system stability. The double forward converter design of the SS-700HM enables it to operate with very high levels of efficiency. Multiple +12V outputs offer enhanced +12 V current capability and offers a wide range of uses.
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C. Douglas Ramey Amphitheatre
Central Park
1340 S 4th St
Louisville, KY 40208
Kentucky Shakespeare Festival's performances are held at the C. Douglas Ramey Amphitheatre in Central Park in Louisville, KY. Central Park is located in the heart of Old Louisville's historic preservation district, at the corner of Fourth & Magnolia Streets. The amphitheater seats up to 1,000 audience members, with additional seating available on the lawn right and left of the stagehouse.
The Old Louisville area was first developed as Louisville's first "suburb", between the 1870s and the early 1900's, and is home to the largest Victorian district in the United States.
Central Park is also home to the Louisville Metro Police Department's 4th Division and the Old Louisville Information Center.
For more information on Old Lousville:
For more information on Central Park:
because we can't act footnotes
Additional Program Notes from Dramaturg Gregory Maupin


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Now reading: Epson P-4000 Multimedia Storage Viewer
Epson Japan has today announced an upgrade to the image viewer P-2000 which doubles the capacity. The P-4000, features a larger 80GB hard disk, 3.5-inch LCD and new higher powered 2600mAh battery, compared to the 2300mAh battery in the P-2000. The device can display JPEG files as well as RAW images from the Epson RD-1 and also play MPEG-4 movies at 640 x 480 pixels. The P-4000 also has slots for CompactFlash Type 2 and SD cards. The expected retail price in Japan is around ¥70,000 (approx $629). More information as we receive it.
Click here to read about the Epson P-2000 Multimedia Image Viewer
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