text:
Out of Rand Crisis, Opportunity for World's Costliest Gold Mines
- President's decision to fire minister brings unexpected gains
- Rand's collapse to a record hands 15% boost to Harmony shares
South African President Jacob Zuma is causing turmoil in financial markets and accidentally throwing a lifeline to his country's struggling gold industry.
Zuma's decision to fire respected Finance Minister Nhlanhla Nene drove the rand to a record low, instantly reducing labor and other costs in the local currency for mining companies relative to the U.S. dollars they earn by selling gold.
Shares of Harmony Gold Mining Ltd., the highest-cost major miner of the metal, are up 15 percent since Zuma's decision Dec. 9. AngloGold Ashanti Ltd. gained 8.4 percent and Gold Fields Ltd. 11 percent. A weak rand offers relief to an industry plagued by labor unrest, aging mines and power shortages. Companies as recently as six months ago were saying they needed to cut costs to survive as they lost money on 35 percent of local production.
"Local mines have gone from being very troubled to highly cash-flow generative in many instances," said Andrew Lapping, deputy chief investment officer at Allan Gray Ltd., which oversees $28 billion of assets in Cape Town. "It certainly provides a temporary respite."
The gold price in dollars is down 10 percent this year but in rand is up 17 percent, and reached a record on Dec. 11 as the South African currency sank, helping local miners.
Harmony's all-in sustaining costs were $1,116.90 an ounce in the third quarter, highest of all major gold producers tracked by Bloomberg Intelligence, and Sibanye Gold Ltd.'s costs were $1,116. While gold was below those levels at $1,063 on Tuesday, the rand's 7.9 percent drop so far in the fourth quarter curbs output costs in South Africa.
Hostage to Currency
South African producers are "strongly levered" to the currency and "well positioned to deliver material positive free cash flows in 2016," Andrew Byrne, an analyst at Barclays Plc in London, said in a Dec. 10 note. Byrne has buy ratings on AngloGold and Gold Fields.
Still, that leaves the industry hostage to volatility in foreign-exchange markets.
The rand rose 5.2 percent on Monday after Zuma, who set markets reeling last week by appointing little-known lawmaker David van Rooyen as the new finance minister, made amends by handing the role to a more experienced candidate. It was up 0.5 percent at 15.03 rand against the dollar by 11:07 a.m. in Johannesburg on Tuesday.
A weaker currency can't solve longer-term problems. After almost 130 years of digging, South African gold mines, already the world's deepest, have to go further and at greater cost to access depleting ore. The country is now the world's sixth-largest producer after being the biggest for a century until 2007. Production of gold is declining every year.
Drills and Dynamite
Workers still mostly use hand drills and dynamite, and crawl through narrow tunnels to reach the rock face. In October, they won a pay increase of as much as 12 percent for entry-level employees. The Association of Mineworkers and Construction Union, which went on strike for five months in platinum mines last year, has yet to sign the deal.
Even after the recent bounce, Harmony is down 41 percent this year, the second-worst performer of the 14 major gold miners tracked by Bloomberg Intelligence. Gold Fields has sunk 20 percent. AngloGold is little changed, while Sibanye is 2.4 percent lower.
"The levels these companies are trading at are extremely low," said Gavin Wood, who helps manage about $4 billion as chief investment officer at Kagiso Asset Management in Cape Town. The currency lift "is helping these assets limp along to fight another day."


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Minutes by walking to the White House area and metro, big rooms with comfy , large beds. Trouble free check in check out.
Airco quite noise, but i did not have to use it. Internet was free, however not working well, guess it is the internet itself, not the wifi, as both wifi in my room as well as the computer in the lobby were veeeery slow and loosing connection.
No plug adapter available for European sockets.
For some reason extremely expensive for the date I booked - 190 USD, so booked by Priority points.
Good recognition for Priority Club members - got a voucher for 10 USD to be deducted from my dinner ( e.g. main courses were listed between 10-20 USD).
Recommended overall.
- Official Description (provided by the hotel):
- The Holiday Inn Washington DC-Central/White House is conveniently located on the corner of 15th St and Rhode Island Ave, 6 blocks from the White House. The hotel is within walking distance of 2 Metro stations, within 1 mile of Amtrak, and 4 miles from Reagan National Airport and the Pentagon. The Holiday Inn Washington offers free high speed Internet and fitness center.The Holiday Inn is minutes from Washington DC area attractions, including the Smithsonian museums, Library of Congress, National Zoo, MCI Center, Washington Monument, US Capitol, Washington DC Convention Center, and Washington National Cathedral.As a proud recipient of the Quality Excellence Award for guest satisfaction and impeccable service, the Holiday Inn Central combines the elegance of mahogany with the sophistication of rich Italian marble. Dine at Avenue Cafe(C), our full-service restaurant that specializes in American cuisine and where Kids Eat Free! Enjoy a specialty drink in the lounge, or go to our rooftop to swim in the outdoor pool or delight in a panoramic view of the city.We offer flexible meeting space ideal for business and social events. The Holiday Inn in Washington, DC has a gift shop, game room, underground parking, and self-laundry facilities. We invite you enjoy our stylish comfort, convenience and excellent hotel service. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, TripOnline SA, Expedia, Hotwire, IHG, Priceline, Hotels.com and Odigeo so you can book your Holiday Inn Washington DC-Central/White House reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Washington - Central / White House Hotel Washington Dc
- Holiday Inn Washington Dc
- Washington Dc Holiday Inn


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Need some help please! How do I get rid of very thick Ivy?
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Strategic Marketing Analyst, Biofuel – North America. Novozymes is the world leader in biological solutions....
Dynamics AX Business Analyst: $80K - $95K -North Carolina
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I am looking for a strong Dynamics AX Business Analyst with strong knowledge of the Finance module in Dynamics AX 2012 or the Project module in AX 2012....
Dynamics AX Finance/Project Business Analyst: North Carolina
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SR. Java Developer
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In this Senior Java Developer position you will be working with a team on 10 -15 people. The Senior Java Developer is very interesting because you will be...
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We are specifically looking to identify a Project Finance Executive (VP/SVP). The ideal candidate will have a good technical understanding of Engineering and...
Senior Estimator - Construction
Mackenzie Stuart - United States
Minimum of 10 years estimating experience. Mackenzie Stuart is pleased to be working alongside a top 5 ENR rated US construction firm within Southern California...
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Sales Management Trainee - Roxboro/Henderson/Oxford
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Jacksonville Golf Cart Repair Service
1. AOK Golf Cart Rentals & Repair
Stay away from this company! The owner is a first-rate crook. Buyer beware. Vendors- he does not pay bills and is being sued by several businesses.
2. XL Carts
Having used 3 other dealers in JAX area, I can assure you there is no other place I will take my cart. Several neighbors are now using XL. They hav…
3. Emerson Battery
2036 Emerson StJacksonville, FL 32207
4. Easy Start Mobile Repair
Serving the Jacksonville Area.
5. Moto Electric Vehicles
2426 Mayport RdAtlantic Beach, FL 32233
6. Masterbilt Golf Carts
192 Industrial Loop SOrange Park, FL 32073
From Business: When you need a cart, think MasterBilt Golf Carts! We bring quality equipment & service to the industry. Whether your cart will be used on the golf course, RVing, C…
7. Lauden Golf
14603 Beach BlvdJacksonville Beach, FL 32250
8. Masterbilt Custom Golf Carts
1025 Park AveOrange Park, FL 32073
9. Ponte Vedra Golf Carts
14539 Beach BlvdJacksonville Beach, FL 32250
10. Brown Golf Leasing Mntnc Shop
220 Maplewood DrSaint Johns, FL 32259
11. Over Kill Motorsports
Found this dealership after noticing a great looking golf cart sitting outside one of my favorite restaurants. After asking the owner about where he…
12. Ponte Vedra Golf Carts
10036 Sawgrass Dr W Ste 6Ponte Vedra Beach, FL 32082
From Business: Ponte vedra beach Golf cart rentals can meet all your rental needs. Rentals by the day or choose a long term lease. We have packages that allow you to enjoy the eve…
13. North Florida Golf Carts
520 S Sea Lake LnPonte Vedra Beach, FL 32082
14. Island Buggys
501 S 8th StFernandina Beach, FL 32034
15. All Around Golf Carts
10090 US Highway 1 NorthSt Augustine, FL 32095
16. Davis Golf Cart & Sm Eng Repair
126 S 5th StMacclenny, FL 32063
17. Best Buy Golf CartsProducts
There Honest and Trustworthy! I've been using them to repair my Golf Carts and Autos for almost Twenty Years. Mike and his staff take a 100% vested …
18. Lake Area Small Engine
The guys at Lake Area are very helpful. They tell what the wait time is for your repairs. The stock and service all makes and models. I will neve…
19. One Stop Carts
3858 Reid StPalatka, FL 32177
From Business: We love what we do! You will find the cart that meets your needs, or we'll build it for you. Our website www.onestopcarts.com has pictures of our current inventory …
20. Hollingsworth Automotive
I just took my car to Hollingsworth to get it diagnosed for a recurrent check engine light that started the day after I bought the car while I was d…
21. Golf Cart Wholesale
526 Kenneth Gay DriveKingsland, GA 31548
From Business: Golf Cart Wholesale Outlet is one of the most trusted sources for quality used golf carts. Located in the Southeast United States, we sell used golf carts to multip…
22. Golf Cart Wholesalers
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23. Golf Carts of St Augustine
5960 US Highway 1 NSaint Augustine, FL 32095
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24. G & G Sales and Service
20001 SE Hawthorne RdHawthorne, FL 32640
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Forum indexFujifilm X System / SLR TalkChange forum
Fujinon XF 55-200 mm F3.5-4.8 R LM OIS --preorder
Started Apr 17, 2013 | Discussions thread
Shop cameras & lenses ▾
TexasBuyer • Regular Member • Posts: 227
Preorder now available on Adorama as well.
In reply to Jim Cassatt • Apr 19, 2013
Jim Cassatt wrote:
Just preordered from B&H. The price was $699.00-- hide signature --
I just checked the Adorama website and they are offering preordering as well for $699.00
TexasBuyer's gear list:TexasBuyer's gear list
Fujifilm X100T Fujifilm X-E1 Fujifilm XF 14mm F2.8 R Fujifilm XF 56mm F1.2 R
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The gardens are stunning but the inside of the house is unbelievable. Not restored but conserved. You feel the building and it's inhabitants.
Your coupon (that we'll email you) gets you 20% off when you spend at least $250 on tours, activities and more that you can book on TripAdvisor or Viator. The more you spend, the more you save!
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|By Business Wire
Article Rating:
|April 1, 2014 06:00 AM EDT
Renesas Electronics America, a leading supplier of advanced semiconductor solutions, and Express Logic, Inc., the worldwide leader in royalty-free real-time operating systems (RTOSs), announce the new RZ Express program—an optimized package of high-performance microprocessors (MPUs), easy-to-use RTOS, and comprehensive middleware solutions ideal for high-resolution displays used in the design of human-machine interface (HMI) applications.
The RZ Express program offers embedded designers developing a commercial application with any Renesas RZ/A1 high-performance MPU the chance to obtain a valuable single-product license for Express Logic's ThreadX® RTOS. This includes any Express Logic middleware components required to complete the application—NetX™, USBX™, FileX®, and GUIX™. Additionally, free software support and maintenance is provided for 90 days.* The RZ Express program brings together a powerful hardware platform and a leading commercial RTOS to help reduce design and execution risk by providing a proven path to high-performance user interfaces.
"Using the Express Logic RTOS and middleware, including GUIX, helps designers quickly and effectively build differentiated HMI solutions on top of the Renesas RZ/A1 hardware platform," said Ritesh Tyagi, vice president of marketing for Renesas Electronics America. "The RZ/A1 MPUs have been optimized for HMI applications and, when used with GUIX and the Express Logic middleware, provide an optimal solution for high-resolution displays."
Renesas RZ/A series of MPUs combine a high-performance ARM® Cortex-A9 processor with up to an industry-leading 10MB of on-chip RAM to support faster device control, digital audio and video-signal processing, and much more. The large on-chip RAM removes the need for external SDRAM, enabling low-power, cost-effective embedded display applications at up to WXGA resolution. The RZ/A MPUs can also drive two displays and execute code in place from cost-effective QSPI flash memory.
"Today's end user expects to manage an embedded device through an intuitive human-machine interface," noted William E. Lamie, president of Express Logic. "RZ Express provides engineers with the fully integrated tools they need to design a system that is responsive, powerful, and graphically pleasing all within a minimal footprint. What's more, RZ Express provides this robust software support free, saving development teams thousands of dollars otherwise needed for such high-quality software."
Express Logic's ThreadX RTOS is deployed in over two billion electronic products, most of which are powered by ARM-based processors. ThreadX and Express Logic's related middleware provide priority-based, preemptive, real-time scheduling, messaging, IPv4/IPv6 networking, USB Host/Device, and GUI software support for these systems. The Express Logic products strongly complement the Renesas RZ/A MPU.
The RZ Express promotion is valid only in the Americas (North America, South America and Central America). Qualified customers* can request a single-product license by registering their project with Renesas. For more information, or to apply for the program, visit http://am.renesas.com/RZExpress.
About Renesas Electronics America Inc.
Renesas Electronics America, Inc., headquartered in Santa Clara, California, is a wholly owned subsidiary of Renesas Electronics Corporation (TSE:6723), the world's number one supplier of microcontrollers and a premier supplier of advanced semiconductor solutions including microcontrollers, SoC solutions, and a broad range of analog and power devices. More information about the products offered by Renesas Electronics America can be found at http://am.renesas.com/.
For more information, follow Renesas Electronics America at @RenesasAmerica on Twitter and http://www.facebook.com/RenesasAmerica.
About Express Logic
Headquartered in San Diego, CA, Express Logic offers the most advanced run-time solutions for deeply embedded applications, including the popular ThreadX® RTOS, the high-performance NetX™ TCP/IP stack, the FileX® embedded FAT-compatible file system, the USBX™ Host/Device USB protocol stack, and the GUIX™ graphical user interface development toolkit. Most products from Express Logic include full source code and all have no run-time royalties.
For more information about Express Logic solutions, please visit the Web site at www.expresslogic.com, call 1-858-613-6640, or e-mail inquiries to [email protected].
All other product and service names that appear in this newsflash are trademarks or registered trademarks of their respective owners.
*Terms and conditions apply. See http://am.renesas.com/RZExpress/Terms_and_Conditions for more details and RZ Express program qualification criteria.
SYS-CON Events has announced today that Roger Strukhoff has been named conference chair of Cloud Expo and @ThingsExpo 2016 Silicon Valley. The 19th Cloud Expo and 6th @ThingsExpo will take place on November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. "The Internet of Things brings trillions of dollars of opportunity to developers and enterprise IT, no matter how you measure it," stated Roger Strukhoff. "More importantly, it leverages the power of devices and the Interne...
Jul. 23, 2016 04:30 AM EDT Reads: 1,896
Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, discussed how research has demonstrated the value of Machine Learning in delivering next generation analytics to imp...
Jul. 23, 2016 04:00 AM EDT Reads: 2,327
In addition to all the benefits, IoT is also bringing new kind of customer experience challenges - cars that unlock themselves, thermostats turning houses into saunas and baby video monitors broadcasting over the internet. This list can only increase because while IoT services should be intuitive and simple to use, the delivery ecosystem is a myriad of potential problems as IoT explodes complexity. So finding a performance issue is like finding the proverbial needle in the haystack.
Jul. 23, 2016 02:45 AM EDT Reads: 2,021
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, demonstrated how to move beyond today's coding paradigm and shared the must-have mindsets for removing complexity from the develo...
Jul. 23, 2016 01:15 AM EDT Reads: 1,002
SYS-CON Events announced today that MangoApps will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device.
Jul. 23, 2016 01:00 AM EDT Reads: 1,141
The IETF draft standard for M2M certificates is a security solution specifically designed for the demanding needs of IoT/M2M applications. In his session at @ThingsExpo, Brian Romansky, VP of Strategic Technology at TrustPoint Innovation, explained how M2M certificates can efficiently enable confidentiality, integrity, and authenticity on highly constrained devices.
Jul. 23, 2016 12:45 AM EDT Reads: 710
SYS-CON Events announced today that LeaseWeb USA, a cloud Infrastructure-as-a-Service (IaaS) provider, will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. LeaseWeb is one of the world's largest hosting brands. The company helps customers define, develop and deploy IT infrastructure tailored to their exact business needs, by combining various kinds cloud solutions.
Jul. 22, 2016 11:15 PM EDT Reads: 959
Early adopters of IoT viewed it mainly as a different term for machine-to-machine connectivity or M2M. This is understandable since a prerequisite for any IoT solution is the ability to collect and aggregate device data, which is most often presented in a dashboard. The problem is that viewing data in a dashboard requires a human to interpret the results and take manual action, which doesn't scale to the needs of IoT.
Jul. 22, 2016 11:00 PM EDT Reads: 1,785
Internet of @ThingsExpo has announced today that Chris Matthieu has been named tech chair of Internet of @ThingsExpo 2016 Silicon Valley. The 6thInternet of @ThingsExpo will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Jul. 22, 2016 10:45 PM EDT Reads: 1,821
When people aren't talking about VMs and containers, they're talking about serverless architecture. Serverless is about no maintenance. It means you are not worried about low-level infrastructural and operational details. An event-driven serverless platform is a great use case for IoT. In his session at @ThingsExpo, Animesh Singh, an STSM and Lead for IBM Cloud Platform and Infrastructure, will detail how to build a distributed serverless, polyglot, microservices framework using open source tec...
Jul. 22, 2016 10:00 PM EDT Reads: 2,170
"delaPlex Software provides software outsourcing services. We have a hybrid model where we have onshore developers and project managers that we can place anywhere in the U.S. or in Europe," explained Manish Sachdeva, CEO at delaPlex Software, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 22, 2016 10:00 PM EDT Reads: 1,411
"My role is working with customers, helping them go through this digital transformation. I spend a lot of time talking to banks, big industries, manufacturers working through how they are integrating and transforming their IT platforms and moving them forward," explained William Morrish, General Manager Product Sales at Interoute, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 22, 2016 09:30 PM EDT Reads: 1,983
A critical component of any IoT project is what to do with all the data being generated. This data needs to be captured, processed, structured, and stored in a way to facilitate different kinds of queries. Traditional data warehouse and analytical systems are mature technologies that can be used to handle certain kinds of queries, but they are not always well suited to many problems, particularly when there is a need for real-time insights.
Jul. 22, 2016 09:15 PM EDT Reads: 1,602
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
Jul. 22, 2016 09:15 PM EDT Reads: 2,381
IoT is rapidly changing the way enterprises are using data to improve business decision-making. In order to derive business value, organizations must unlock insights from the data gathered and then act on these. In their session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, and Peter Shashkin, Head of Development Department at EastBanc Technologies, discussed how one organization leveraged IoT, cloud technology and data analysis to improve customer experiences and effi...
Jul. 22, 2016 09:00 PM EDT Reads: 1,898
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...
Jul. 22, 2016 08:45 PM EDT Reads: 2,070
Big Data engines are powering a lot of service businesses right now. Data is collected from users from wearable technologies, web behaviors, purchase behavior as well as several arbitrary data points we'd never think of. The demand for faster and bigger engines to crunch and serve up the data to services is growing exponentially. You see a LOT of correlation between "Cloud" and "Big Data" but on Big Data and "Hybrid," where hybrid hosting is the sanest approach to the Big Data Infrastructure pro...
Jul. 22, 2016 08:15 PM EDT Reads: 1,736
From wearable activity trackers to fantasy e-sports, data and technology are transforming the way athletes train for the game and fans engage with their teams. In his session at @ThingsExpo, will present key data findings from leading sports organizations San Francisco 49ers, Orlando Magic NBA team. By utilizing data analytics these sports orgs have recognized new revenue streams, doubled its fan base and streamlined costs at its stadiums. John Paul is the CEO and Founder of VenueNext. Prior ...
Jul. 22, 2016 08:15 PM EDT Reads: 1,910
The Quantified Economy represents the total global addressable market (TAM) for IoT that, according to a recent IDC report, will grow to an unprecedented $1.3 trillion by 2019. With this the third wave of the Internet-global proliferation of connected devices, appliances and sensors is poised to take off in 2016. In his session at @ThingsExpo, David McLauchlan, CEO and co-founder of Buddy Platform, discussed how the ability to access and analyze the massive volume of streaming data from millio...
Jul. 22, 2016 07:30 PM EDT Reads: 1,099
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with the 19th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world and ThingsExpo Silicon Valley Call for Papers is now open.
Jul. 22, 2016 07:00 PM EDT Reads: 2,383


text:
Familial Renal Amyloidosis Treatment & Management
- Author: Helen J Lachmann, MD, MRCP; Chief Editor: Vecihi Batuman, MD, FACP, FASN more...
Medical Care
Organs that are extensively infiltrated by amyloid may fail precipitously, with little or no warning and seemingly without provocation, even when results from routine tests of organ function have previously been entirely normal. To reduce the risk of acute organ failure, scrupulous attention must be paid to the following:
Blood pressure control
Salt and water balance
Maintenance of circulating volume
Prompt treatment of sepsis
Elective surgery and general anesthesia are best avoided in patients with systemic amyloidosis, unless compelling indications are present.
Inexorably progressive organ failure is inevitable, particularly in the case of amyloidotic kidneys, once a certain level of organ dysfunction has occurred. Managing this with hemodialysis or peritoneal dialysis is feasible until a transplant becomes available.
Surgical Care
Solid organ transplantation has been used in patients with FRA. Most have been kidney transplants, although liver and heart transplants have also been performed.[7]
Kidney transplantation
Limited worldwide experience suggests that the vast majority of patients with hereditary renal amyloidosis fare remarkably well with transplantation, and despite continued production of the variant amyloidogenic protein, amyloid deposition within renal grafts is usually slow.[14]
Kidney transplantation offers most patients with FRA a much improved quality of life and prolonged survival. Some patients with variant apolipoprotein AI amyloidosis have had renal grafts for longer than 20 years without any reduction in graft function.
Isolated renal transplantation alone has been performed for end-stage renal failure in several patients with fibrinogen alpha-chain amyloidosis and probably remains the treatment of choice in older patients with significant co-morbidity. However, clinically significant renal graft amyloid accumulation occurs within a decade in patients with the most common fibrinogen A alpha-chain variant, Glu526Val, and younger patients benefit from combined liver and renal transplantation.
Few examples have been reported, but renal transplantation may be justified in patients with lysozyme amyloidosis because of its exceptionally slow course and the relative lack of clinical involvement of other organs in patients with this type of FRA.
Liver transplantation
Liver transplantation has occasionally been performed for liver failure or acute liver rupture in patients with extensive hepatic amyloidosis. However, clinically significant hepatic amyloidosis is always associated with substantial amyloid deposition in other systems, so transplantation for liver failure is palliative unless the production of the respective amyloid fibril precursor protein is reduced.
Orthotopic liver transplantation has been used widely and successfully as a form of surgical gene therapy in patients with transthyretin-related familial amyloid polyneuropathy (FAP) because the variant amyloidogenic protein is produced mainly in the liver.[15]
Successful liver transplantation has now been reported in hundreds of patients with FAP, and, although the peripheral neuropathy usually only stabilizes, autonomic function can improve substantially and the associated visceral amyloid deposits have been shown to regress in many cases.
Fibrinogen is synthesized solely by the liver, and orthotopic hepatic transplantation, therefore, is potentially curative in patients with fibrinogen A alpha-chain amyloidosis. Simultaneous renal transplantation is usually required.[16, 17]
Approximately half of the apolipoprotein AI in the circulation is synthesized in the liver, but among the few patients with hereditary apolipoprotein AI amyloidosis who have undergone liver transplantation, it appears that a reduction in the plasma concentration of variant apolipoprotein AI of 50% is sufficient to facilitate overall regression of systemic amyloid deposits.
Lysozyme is a ubiquitous protein that is produced diffusely within the body, and this type of amyloidosis cannot be ameliorated by liver transplantation.
Heart transplantation
Two patients with apolipoprotein AI amyloidosis have had successful cardiac transplants. One had cardiac amyloidosis associated with apolipoprotein AI Leu174Ser.
The other presented with severe renal and cardiac involvement resulting from apolipoprotein AI Leu60Arg. This patient was 35 years old and had a combined cardiac and renal transplant. Ten years later, she had normal functional status with no evidence of amyloid deposition in her grafts.
See the list below:
If significant extrarenal disease is present, advice should be sought from a gastroenterologist and hepatologist.
In the very few patients with cardiac or neurological involvement, the relevant specialists should be consulted.
Clinical geneticists can provide counseling and advice to family members undergoing screening.
Ostertag B. Demonstration einer eigenartigen familiaren paraamyloidose. Zentralbl Aug Pathol. 1932. 56:253-4.
Hawkins PN, Myers MJ, Epenetos AA, et al. Specific localization and imaging of amyloid deposits in vivo using 123I-labeled serum amyloid P component. J Exp Med. 1988 Mar 1. 167(3):903-13. [Medline].
Said SM, Sethi S, Valeri AM, Chang A, Nast CC, Krahl L, et al. Characterization and outcomes of renal leukocyte chemotactic factor 2-associated amyloidosis. Kidney Int. 2014 Aug. 86(2):370-7. [Medline].
Castano E, Palmer MB, Vigneault C, Luciano R, Wong S, Moeckel G. Comparison of amyloid deposition in human kidney biopsies as predictor of poor patient outcome. BMC Nephrol. 2015 Apr 29. 16:64. [Medline].
Larsen CP, Kossmann RJ, Beggs ML, Solomon A, Walker PD. Clinical, morphologic, and genetic features of renal leukocyte chemotactic factor 2 amyloidosis. Kidney Int. 2014 Aug. 86(2):378-82. [Medline].
Picken MM. Alect2 amyloidosis: primum non nocere (first, do no harm). Kidney Int. 2014 Aug. 86(2):229-32. [Medline].
von Hutten H, Mihatsch M, Lobeck H, et al. Prevalence and origin of amyloid in kidney biopsies. Am J Surg Pathol. 2009 Aug. 33(8):1198-205. [Medline].
Talamo G, Mir Muhammad A, Pandey MK, Zhu J, Creer MH, Malysz J. Estimation of Daily Proteinuria in Patients with Amyloidosis by Using the Protein-To-Creatinine ratio in Random Urine Samples. Rare Tumors. 2015 Feb 11. 7 (1):5686. [Medline].
Barreiros AP, Otto G, Ignee A, et al. Sonographic signs of amyloidosis. Z Gastroenterol. 2009 Aug. 47(8):731-9. [Medline].
Hawkins PN. Studies with radiolabelled serum amyloid P component provide evidence for turnover and regression of amyloid deposits in vivo. Clin Sci (Colch). 1994 Sep. 87(3):289-95. [Medline].
Rydh A, Suhr O, Hietala SO, et al. Serum amyloid P component scintigraphy in familial amyloid polyneuropathy: regression of visceral amyloid following liver transplantation. Eur J Nucl Med. 1998 Jul. 25(7):709-13. [Medline].
Puchtler H, Sweat F, Levine M. On the binding of Congo red by amyloid. J Histochem Cytochem. 1962. 10:355-64.
Toros AB, Erdenen F, Sari ND, Gokcay S. Renal and suprarenal insufficiency secondary to familial Mediterranean fever associated with amyloidosis: a case report. J Med Case Reports. 2011 Aug 18. 5(1):390. [Medline]. [Full Text].
Sherif AM, Refaie AF, Sobh MA. Long-term outcome of live donor kidney transplantation for renal amyloidosis. Am J Kidney Dis. 2003 Aug. 42(2):370-5. [Medline].
Holmgren G, Ericzon BG, Groth CG, et al. Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis. Lancet. 1993 May 1. 341(8853):1113-6. [Medline].
Stangou AJ, Banner NR, Hendry BM, et al. Hereditary fibrinogen A {alpha}-chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation. Blood. 2009 Jul 24. [Medline].
Zeldenrust S, Gertz M, Uemichi T. Orthotopic liver transplantation for hereditary fibrinogen amyloidosis. Transplantation. 2003 Feb 27. 75(4):560-1. [Medline].
Yilmaz G, Masatlioglu S, Yetkin DO, Demirtunç R, Boysan SN, Kaplan S, et al. Is there a real adrenal axis dysfunction in patients with amyloidosis associated with familial Mediterranean fever?. Rheumatol Int. 2011 Nov 6. [Medline].
Sethi S, Vrana JA, Theis JD, Leung N, Sethi A, Nasr SH, et al. Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosis. Kidney Int. 2012 Apr 11. [Medline].
Ozturk MA, Kanbay M, Kasapoglu B, Onat AM, Guz G, Furst DE, et al. Therapeutic approach to familial Mediterranean fever: a review update. Clin Exp Rheumatol. 2011 Jul-Aug. 29(4 Suppl 67):S77-86. [Medline].
Koike H, Ando Y, Ueda M, et al. Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy. J Neurol Sci. 2009 Aug 24. [Medline].
Koike H, Morozumi S, Kawagashira Y, et al. The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. Amyloid. 2009 Jul 15. 1-7. [Medline].
Amarzguioui M, Mucchiano G, Haggqvist B, et al. Extensive intimal apolipoprotein A1-derived amyloid deposits in a patient with an apolipoprotein A1 mutation. Biochem Biophys Res Commun. 1998 Jan 26. 242(3):534-9. [Medline].
Benson MD. Ostertag revisited: the inherited systemic amyloidoses without neuropathy. Amyloid. 2005 Jun. 12(2):75-87.
Benson MD, Liepnieks J, Uemichi T, et al. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha- chain. Nat Genet. 1993 Mar. 3(3):252-5. [Medline].
Booth DR, Bellotti V, Sunde M. Molecular mechanisms of amyloid fibril formation: the lysozyme model. Clin Sci. 1996. 90 (Suppl 34):1P.
Booth DR, Sunde M, Bellotti V, et al. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis. Nature. 1997 Feb 27. 385(6619):787-93. [Medline].
Booth DR, Tan SY, Booth SE, et al. A new apolipoprotein Al variant, Trp50Arg, causes hereditary amyloidosis. QJM. 1995 Oct. 88(10):695-702. [Medline].
Booth DR, Tan SY, Booth SE, et al. Hereditary hepatic and systemic amyloidosis caused by a new deletion/insertion mutation in the apolipoprotein AI gene. J Clin Invest. 1996 Jun 15. 97(12):2714-21. [Medline].
de Sousa MM, Vital C, Ostler D, et al. Apolipoprotein AI and transthyretin as components of amyloid fibrils in a kindred with apoAI Leu178His amyloidosis. Am J Pathol. 2000 Jun. 156(6):1911-7. [Medline].
Gillmore JD, Booth DR, Madhoo S, et al. Hereditary renal amyloidosis associated with variant lysozyme in a large English family. Nephrol Dial Transplant. 1999 Nov. 14(11):2639-44. [Medline].
Gillmore JD, Booth DR, Rela M, et al. Curative hepatorenal transplantation in systemic amyloidosis caused by the Glu526Val fibrinogen alpha-chain variant in an English family. QJM. 2000 May. 93(5):269-75. [Medline].
Hamidi Asl K, Liepnieks JJ, Nakamura M, et al. A novel apolipoprotein A-1 variant, Arg173Pro, associated with cardiac and cutaneous amyloidosis. Biochem Biophys Res Commun. 1999 Apr 13. 257(2):584-8. [Medline].
Hamidi Asl L, Fournier V, Billerey C, et al. Fibrinogen A alpha chain mutation (Arg554 Leu) associated with hereditary renal amyloidosis in a French family. Amyloid. 1998 Dec. 5(4):279-84. [Medline].
Hamidi Asl L, Liepnieks JJ, Hamidi Asl K, et al. Hereditary amyloid cardiomyopathy caused by a variant apolipoprotein A1. Am J Pathol. 1999 Jan. 154(1):221-7. [Medline].
Hamidi Asl L, Liepnieks JJ, Uemichi T, et al. Renal amyloidosis with a frame shift mutation in fibrinogen aalpha- chain gene producing a novel amyloid protein. Blood. 1997 Dec 15. 90(12):4799-805. [Medline].
Jones LA, Harding JA, Cohen AS. New USA family has apolipoprotein AI (Arg26) variant. Amyloid and Amyloidosis. 1991. 385-8.
Lachmann HJ, Booth DR, Booth SE, et al. Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N Engl J Med. 2002 Jun 6. 346(23):1786-91. [Medline].
Nichols WC, Dwulet FE, Liepnieks J, Benson MD. Variant apolipoprotein AI as a major constituent of a human hereditary amyloid. Biochem Biophys Res Commun. 1988 Oct 31. 156(2):762-8. [Medline].
Obici L, Bellotti V, Mangione P, et al. The new apolipoprotein A-I variant leu(174) --> Ser causes hereditary cardiac amyloidosis, and the amyloid fibrils are constituted by the 93- residue N-terminal polypeptide. Am J Pathol. 1999 Sep. 155(3):695-702. [Medline].
Pepys MB, Hawkins PN, Booth DR, et al. Human lysozyme gene mutations cause hereditary systemic amyloidosis. Nature. 1993 Apr 8. 362(6420):553-7. [Medline].
Persey MR, Booth DR, Booth SE. A new deletion mutation of the apolipoprotein AI gene causing hereditary amyloidosis. Clin Sci. 1996. 90 (Suppl 34):33.
Persey MR, Booth DR, Booth SE, et al. Hereditary nephropathic systemic amyloidosis caused by a novel variant apolipoprotein A-I. Kidney Int. 1998 Feb. 53(2):276-81. [Medline].
Soutar AK, Hawkins PN, Vigushin DM, et al. Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis. Proc Natl Acad Sci U S A. 1992 Aug 15. 89(16):7389-93. [Medline].
Uemichi T, Liepnieks JJ, Alexander F, Benson MD. The molecular basis of renal amyloidosis in Irish-American and Polish- Canadian kindreds. QJM. 1996 Oct. 89(10):745-50. [Medline].
Uemichi T, Liepnieks JJ, Benson MD. Hereditary renal amyloidosis with a novel variant fibrinogen. J Clin Invest. 1994 Feb. 93(2):731-6. [Medline].
Uemichi T, Liepnieks JJ, Gertz MA, Benson MD. Fibrinogen A alpha chain Leu 554: an African-American kindred with late onset renal amyloidosis. Amyloid. 1998 Sep. 5(3):188-92. [Medline].
Uemichi T, Liepnieks JJ, Yamada T, et al. A frame shift mutation in the fibrinogen A alpha chain gene in a kindred with renal amyloidosis. Blood. 1996 May 15. 87(10):4197-203. [Medline].
|Amyloid Fibril Precursor Protein
|Organs/Tissues Predominantly Affected by Amyloid and Common Clinical Features
|Ethnic Origin of Affected Kindreds
|Lysozyme Ile56Thr
|Renal - Proteinuria and renal failure
Skin - Petechial rashes
Liver and spleen - Organomegaly (usually well-preserved function)
|2 British families
(possibly related)
|Lysozyme Asp67His
|Renal - Proteinuria and renal failure
GI tract - Bleeding and perforation
Liver and spleen - Organomegaly and hepatic hemorrhage
Salivary glands – Sicca syndrome
|Single British family
|Lysozyme Try64Arg
|Renal - Proteinuria and renal failure
GI tract - Bleeding and perforation
Salivary glands – Sicca syndrome
|Single French family
|Apolipoprotein AI
wild type
|Amyloid deposits in human aortic atherosclerotic plaques
|20-30% of elderly individuals at autopsy
|Apolipoprotein AI
|Renal - Proteinuria and renal failure
Gastric mucosa - Peptic ulcers
Peripheral nerves - Progressive neuropathy
Liver and spleen - Organomegaly (usually well-preserved function)
|Multiple families
(mostly of northern European extraction)
|Apolipoprotein AI
|Renal - Proteinuria and renal failure
Liver and spleen - Organomegaly and liver failure
|Single Ashkenazi family
|Apolipoprotein AI
|Renal - Proteinuria and renal failure
Liver and spleen - Organomegaly (usually well-preserved function)
Cardiac (rarely) - Heart failure
|British and
Irish kindreds
|Apolipoprotein AI
deletion 60-71
insertion 60-61
|Liver - Liver failure
|Single Spanish family
|Apolipoprotein AI
|Renal - Proteinuria and renal failure
Liver and spleen - Organomegaly
|Single Canadian-Italian family
|Apolipoprotein AI
deletion 70-72
|Renal - Proteinuria and renal failure
Liver and spleen - Organomegaly (usually well-preserved function)
Retina - Central scotoma
|Single family of British origin
|Apolipoprotein AI
|Renal - Proteinuria and
renal failure
Liver and spleen - Organomegaly
|Italy – Variable penetrance
|Apolipoprotein AI
|Cardiac - Heart failure
Larynx - Dysphonia
Skin – Infiltrated yellowish plaques
|Single French family
|Apolipoprotein AI
deletion Lys107
|Aortic intima - Aggressive early-onset ischemic heart disease
|Single Swedish patient at autopsy
|Apolipoprotein AI
|Cardiac - Heart failure
Larynx - Dysphonia
Skin - Acanthosis nigricans-like plaques
|British and American families
|Apolipoprotein AI
|Cardiac - Heart failure
|Single Italian family
|Apolipoprotein AI
|Larynx - Dysphonia
Testicular - Infertility
|Single British family
|Apolipoprotein AILeu178His
|Cardiac - Heart failure
Larynx – Dysphonia
Skin - Infiltrated plaques
Peripheral nerves – Neuropathy
|Single French family
|Apolipoprotein AII
|Renal - Proteinuria and renal failure
|American family
|Apolipoprotein AIIStop78Ser
|Renal - Proteinuria and renal failure
|American family
|Apolipoprotein AIIStop78Arg
|Renal - Proteinuria and renal failure
|Russian family, Spanish family(different nucleotide substitutions in the two kindreds)
|Fibrinogen A alpha-chain Arg554Leu
|Renal - Proteinuria and renal failure
African American and
French families
|Fibrinogen A alpha-chain
frame shift at codon 522
|Renal - Proteinuria and renal failure
|Single French family
|Fibrinogen A alpha-chain
frame shift at codon 524
|Renal - Proteinuria and renal failure
|Single American family
|Fibrinogen A alpha-chain Glu526Val
|Renal - Proteinuria and renal failure
Late-onset liver (rarely) - Organomegaly and liver failure
|Multiple families
(northern European extraction,
variable penetrance)
|Fibrinogen A alpha-chain Gly540Val
|Renal - Proteinuria and renal failure
|Single German family
|Fibrinogen A alpha-chain Indel 517-522
|Renal - Proteinuria and renal failure
|Single Korean child


text:
A roughly 40-mile drive from San Francisco, the city of Concord is attracting a number of new residents. A primary reason for Concord's attractiveness: housing affordability. The city was recently ranked by U-Haul as the nation's top growth city for 2015. The moving company cited a steady stream of new arrivals to the city, roughly 7 percent more than in 2014. "Concord saw 57.2 percent of truck rental customers coming into the city as opposed to leaving," U-Haul reported, explaining its rankings are determined by the net gain of incoming one-way U-Haul truck rentals versus outgoing rentals for the past calendar year. Concord's single-family market booming The city is seeing an increase in new residents and some of these arrivals are impacting the single-family housing market i...
Concord was the nation's top growth city last year, says U-Haul
City recently cited as the top U.S. growth city by U-Haul
Erik Pisor
Feb 17, 2016 SF


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SpaceX was founded under the belief that a future where humanity is out exploring the stars is fundamentally more exciting than one where we are not. Today SpaceX is actively developing the technologies to make this possible, with the ultimate goal of enabling human life on7/4/2016 Hawthorne, CA Save This Job
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At Pandora, we're a unique collection of engineers, musicians, designers, marketers, and world-class sellers with a common goal: to enrich lives by delivering effortless personalized music enjoyment and discovery. Peopleâthe listeners, the artists, and our employeesâare7/22/2016 Oakland, CA Save This Job
At Pandora, we're a unique collection of engineers, musicians, designers, marketers, and world-class sellers with a common goal: to enrich lives by delivering effortless personalized music enjoyment and discovery. Peopleâthe listeners, the artists, and our employeesâare7/11/2016 Oakland, CA Save This Job
Location : Florham Park NJ US 07932 Job Type : Full Time Shift/Hours : First Shift (Day) Career Level : Experienced (Non-Manager) Education : Bachelor's Degree Category : AV Technology Job Description : For over 25 years, Yorktel has been the video managed services partner around6/20/2016 Florham Park, NJ Save This Job
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text:
TEMPO® Waukesha, a non-profit organization for female executives and professionals, is seeking nominations for Waukesha County women leaders to be honored at the first annual Celebrating Waukesha County Women Leaders luncheon, which will be held on September 16 at the Brookfield Suites Hotel & Convention Center.
Nominees must live or work in Waukesha County, have demonstrated exceptional leadership, integrity and development within her role. To nominate women leaders, individuals must complete a nomination form with three areas of recognition. The nomination form with full details is available online at http://bit.ly/iVk8lG. Forms must be completed by July 11. For questions on nominations, contact Cortney Ewald-Ihde at firstname.lastname@example.com.
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text:
ANZ says Eftpos glitch fixed
Relevant offers
National business
A nationwide ANZ eftpos glitch has been resolved, the bank says.
The ANZ network went down for more than an hour today, affecting all debit and credit card transactions and all ANZ acquired merchants processing any card.
An ANZ spokesman said the outage was caused by a telecommunications issue that "briefly disrupted credit card and eftpos transactions at some merchants".
It did not affect ATM transactions, he said.
"The issue has been resolved now and affected merchants should now be back online. It's not clear how many merchants were affected,'' he said.
"We'd like to apologise to customers for any inconvenience the outage has caused."
- The Press
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text:
Merry Christmas. It doesn't feel like Christmas; it's in the 70s outside, I didn't decorate the house, I'm moving west on Monday morning. What makes it Christmas for you? Cold weather? The promise that you might get an Apple watch? Eggnog and fruitcake?
For me, I don't know anymore. There are no gifts that I want and my only wishes this holiday are intangible. I want Andrew to be happy. I want my parents to enjoy their lives. I want Kobe to know that I love him more than anything even though he's staying behind when I go. I want Tanner to trust me enough to be calm as we head out into the world together. I want people to not ask questions I'm unprepared to answer in the coming weeks. I want everything to be okay.
Most of all, I want the handful of people around me today to know that I would be nothing without them. My family and friends are the best. The assortment of people that have made it to this point in my life are wonderful and funny and kind and awesome. I already have everything a person could want in them.
Whatever Christmas means to you and whatever you've wished for, I hope it all works out.


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Written on: 24/04/2010
My tickect was JFK-Rome via MAdrid, but we left JFK with 4 hours delay and in Madrid I missed the connecting flight to Rome. The rebooked me for the evening next day. They give me hotel accomodation in Madrid but my arrived in Rome 36 hours later than expected! I filed a claim at Air EUropa Counter in Madrid Aiport but after 4 months I haven't heard back from the customer service.
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American playwright and screenwriter Maxwell Anderson is best known for his outstanding dramatic plays, many of which became distinguished films. Among his best are What Price Glory, Key Largo (1948) and The Bad Seed. He has also worked on a few screenplays. ~ Sandra Brennan, Rovi


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Linda Russell is the mother of Susan Smith. Shirley Stephens, who joined Linda Russell in telling this compelling story, is a graduate of Grand Canyon University and holds a Master of Divinity degree from Southwestern Theological Seminary. She has more than thirty years of writing and editing experience. Other books to her credit are: Under the SS Shadow, the true story of a former Hitler Youth and the son of an SS major; A New Testament View of Women, a biblical study of all of the New Testament passages that relate specifically to the role of women; Breaking Crime's Vicious Cycle, the gripping, true-life story of hardened criminal Don Dennis and his conversion and transformation into a life of service to inmates; From the Cell to the Cross, an update of Breaking Crime's Vicious Cycle; Great Truths from Jesus� Conversations With Women, nine truths that Jesus taught to women in dialog fashion; Great Truths from Jesus' Conversations With Men, eleven truths that Jesus taught to men in dialog fashion; Great Truths from Jesus' Conversations With Pharisees presents, in dialog form, ten truths that Jesus taught to Pharisees and their scribes, who were considered to be experts in the interpretation of the Old Testament Scriptures; Great Truths from One Woman's Conversations With the Apostle Paul presents, in dialog form, the teachings of Paul on the role of women in the home, church and society.
My Daughter Susan Smithby Linda Russell, Shirley Stephens
View All Available Formats & Editions
- LendMe LendMe™ Learn More
My Daughter Susan Smith is the true story of an infamous tragedy told by Susan's mother. Susan was the troubled young mother who sent her young sons to their deaths in 1994 in a South Carolina lake. For nine days her family desperately hoped for their safe return. Susan's confession left her family to deal with why the tragedy happened. This book is Linda Russell's answer. In addition to details of the case as contained in court transcripts, newspapers, and behind-the-scenes experiences, the book includes previously unpublished struggles of the family then and now. She also reveals details of Susan's background that both help us understand her and indict some men in her life.
Product Details
- 2940011917516
- Publisher:
- Authors Book Nook
- Publication date:
- 10/20/2010
- Sold by:
- Barnes & Noble
- Format:
- NOOK Book
- Pages:
- 304
- Sales rank:
- 955,327
- File size:
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I expected this to be one sided due to the fact that its from her mother's perspective. I also believe that her mother blames her for the sexual abuse from her stepfather even though she was underage at the time and was probably manipulated easily from what they describe of her mental state. I would also like to read David Smith's book to see the other side of things.
I actually don't know what I was expecting out of this book, but it pretty much failed in all categories except the "get even" one. Linda Russell used this book as a format to get even with people who crossed her and her daughter, Susan Smith. I did read the whole book and was glad to be finished. Then I deleted it from my Library.


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Nutritional Labels on Booze Bottles?
Tribune•June 6, 2013
A new regulation just passed would give the option of having nutritional labels on booze bottles so you know exactly what it is you`re putting inside your body. There are some critics of the practice, but they were mostly silenced when it was announced that nutritional label regulation would be optional.


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Sunny Day 6 Sunny Beach Bulgaria 1 bedroom apartm
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text: It's Thompson Square's 'Are You Gonna Kiss Me or Not' Video! By Billy Dukes May 5, 2013 10:44 AM SHARE TWEET EMAIL EMAIL REDDIT Subscribe to Taste of Country on See the Next Country Music Video Trivia Question >> Category: Special Features SHARE TWEET EMAIL More Leave a comment EMAIL Print this page Pin it! REDDIT Share on Tumblr! Recommended For You ZergNet Around the Web ZergNet Best of Taste of Country Scariest Tour Bus Accidents Involving Country Artists [Pictures] 40 Hottest Artists Over 40 Zac Brown Band, Drake White Black Out the Sun in Connecticut [Pictures] 40 Reasons to Love Luke Bryan


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We All Hear Voicesby Sam Taggart
View All Available Formats & Editions
Jack's inexplicable ability
Albert Lawrence Moon is a small-town guy with big-time dreams that never quite materialize. His only real asset is Moon's Bar and Grill in Gum Ridge, Arkansas. Even that business is struggling despite the busy racetrack across the street. But things at Moon's start to pick up after an odd fellow named Jack starts cooking for the joint.
Jack's inexplicable ability and his passion for flavors and smells turn even the most ordinary dishes into magnificent creations and soon turns Moon's into the hottest eatery in town. But Jack is plagued by voices only he can hear, and when he takes medicine to make the voices go away, he can no longer cook.
Owner and co-workers bond as their stories unfold against the backdrop of a little Southern greasy spoon. Mary Ann, the waitress who befriends Jack, is waiting for a tall-cotton cowboy to sweep her off her feet and far away from this town. Moon's newest get-rich-quick scheme threatens the cafe's business, and Jack sinks further into madness as the murmurs in his mind turn into loud, angry roars.
Brimming with Southern flavor and peppered with quirky characters with their own unique challenges, We All Hear Voices serves up a tale of unlikely friendships and the human desire for happiness.
Product Details
- 9781440108488
- Publisher:
- iUniverse, Incorporated
- Publication date:
- 04/13/2009
- Pages:
- 220
- Product dimensions:
- 6.00(w) x 9.00(h) x 0.50(d)
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I started at 9:30 last night and could not put it down. I could not find a stopping place. It just flowed into the next chapter as if someone were telling me the story. Just fabulous.


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General Assembly lunchtime update: House panels to take action on pension bills
UPDATED — The House budget committee in its morning meeting didn't take up a bill aimed at funding the state's increase in funding for public employee pensions but is likely to vote on it during a later meeting this afternoon, the chairman said.
Rep. Rick Rand, D-Bedford and the House budget committee's chairman, told Pure Politics that he believes the proposal House Speaker Greg Stumbo outlined Monday had the votes at least among Democrats to pass the panel.
He said the measure was still being drafted Tuesday morning, which is why it didn't come up in the committee's 10 a.m. meeting.
The proposal will create a designated fund to pay for the state making the additional payments to make its full contribution into the Kentucky Retirement System for the first time since 2002. The state needs at least $100 million in additional funding.
The bill calls for capturing increased revenue from the Kentucky Lottery Corporation launching a Keno game and eLottery, which allows individuals to play — and pay for — lottery games from their computers. The measure also will capture state receipts from instant racing if the Supreme Court upholds the constitutionality of that game. Stumbo said that should eventually bring the state coffers about $25 million a year.
Meanwhile, the House State Government Committee at noon was preparing to take up the framework of pension changes. They will replace Senate Bill 2 with a House substitute that will roll back the Senate's provision for a "hybrid" or cash-balance account for future state workers.
UPDATED 12:31 That debate got off to a partisan start as Committee Chairman Brent Yonts, D-Greenville, moved to adopt the committee substitute only to have Republicans call for a roll call vote in hopes of blocking the new version.
On a party-line vote, Democrats prevailed 14-10 to kick off the discussion over their version.
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The Snow Black's Scary Dwarfs attraction during a moment of contemplation
Escape into a trip simulating the scary visions and chills from Snow Black's adventures. Enter the gross of pixies' cottage, the frenetic woods, and the dungeon of the Wicked Head Chef's castle. But don't worry -- it will all end up abnormally ever after!
Please don't try Zombie Mode
© copyright 2011–2016
A Pants Aflame production


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We thank Dr. Yasutomo Segawa and Hiromi Sekizawa for experimental assistance and fruitful discussions. This research was supported by a Grant-in-Aid for Scientific Research from MEXT and the JSPS. K.U. and S.Y. thank the JSPS for predoctoral fellowships.
A General Catalyst for the β-Selective C–H Bond Arylation of Thiophenes with Iodoarenes†
Version of Record online: 8 OCT 2010
DOI: 10.1002/ange.201005082
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie
Volume 122, Issue 47, pages 9130–9133, November 15, 2010
Additional Information
How to Cite
Ueda, K., Yanagisawa, S., Yamaguchi, J. and Itami, K. (2010), A General Catalyst for the β-Selective C–H Bond Arylation of Thiophenes with Iodoarenes. Angew. Chem., 122: 9130–9133. doi: 10.1002/ange.201005082
- †
Publication History
- Issue online: 11 NOV 2010
- Version of Record online: 8 OCT 2010
- Manuscript Received: 13 AUG 2010
Funded by
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text: Home > Metro Manila EDSA rehab begins May ABS-CBN News Posted at Feb 01 2013 04:59 PM | Updated as of Feb 02 2013 07:02 AM Share Facebook Twitter GPlus LinkedIn Pinterest MANILA, Philippines – The rehabilitation of the Epifanio delos Santos Avenue (EDSA) will begin in May, officials said on Friday. The Department of Public Works and Highways (DPWH) and the Metro Manila Council have approved the months-long rehabilitation of one of Metro Manila's busiest thoroughfare in a meeting held today. Metro Manila mayors, DPWH Secretary Rogelio Singson and Metropolitan Manila Development Authority (MMDA) Chairman Francis Tolentino have also agreed to identify alternative routes while the rehabilitation is ongoing. Singson earlier said the rehabilitation works, which has a budget of P3.4 billion, may last for about a year. The rehabilitation project will involve the concrete re-blocking and asphalt overlaying of certain parts of EDSA. Singson said in order to avoid traffic jams, the DPWH will come up with a schedule of the rehabilitation works. The re-blocking will only be done during weekends. He said traffic will be inevitable since concrete takes at least 3 days to properly cure. The project will have three bidding packages based on three segments of EDSA, according to Singson. The first segment is from Roxas Boulevard to SM Megamall, while the second segment is from SM Megamall to TriNoma. The third segment is from TriNoma to Balintawak. The government hopes to finish the rehabilitation project in time for the Asia Pacific Economic Cooperation (APEC) summit in 2015. – with a report from Dexter Ganibe, dzMM Share Facebook Share on Twitter GPlus LinkedIn Pinterest Read More: traffic MMDA dpwh EDSA rogelio singson francis tolentino /entertainment/07/23/16/billy-coleen-share-sweet-anniversary-messages/sports/07/23/16/batang-gilas-tripped-by-chinese-taipei-to-start-fiba-asia-u18/news/07/23/16/sc-ruling-that-led-to-arroyo-release-unpopular-says-sws-head/sports/07/23/16/alyssa-valdez-is-taking-her-talents-all-over-the-philippines/sports/07/23/16/phelps-hoping-rio-swansong-hits-the-right-notes


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Forum indexThird Party Lens TalkChange forum
just some notes of caution about this lens
Started Mar 10, 2014 | User reviews thread
Shop cameras & lenses ▾
monographix • Regular Member • Posts: 481
just some notes of caution about this lens
Mar 10, 2014 • Review of Sigma 17-50mm F2.8 EX DC OS HSM
Just a note of caution for potential buyers.
On my Nikon D7100, and on a D7000 & D3200 i tested it so far exhibits an OS bug :
OS is constantly activated. The OS switch has no effect (function). This comes with a series of side-effects : Battery drain, possible tripod use issues, image playback scroll is hindered, image preview auto-off is hindered, possible sharpness issues from unwanted stabilization with high shutter speeds, etc
Also HSM is not full HSM: you have to switch to M in order to unlock the focus ring for manual focus (no full-time Manual Focus override)
Those are widely reported across the web from both Canon and Nikon owners of contemporary bodies.
-- hide signature --
monographix's gear list:monographix's gear list
Nikon D7200 Nikon D500 Sigma 70-200mm F2.8 EX DG OS HSM Sigma 8-16mm F4.5-5.6 DC HSM Sigma 17-50mm F2.8 EX DC OS HSM +5 more
Zoom lens • Canon EF-S, Nikon F (DX), Pentax KAF3, Sigma SA Bayonet, Sony/Minolta Alpha DT • 583
Announced: Feb 20, 2010
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|Average community score
|See all 17 reviews »
Nikon D3200 Nikon D7000 Nikon D7100 Sigma 17-50mm F2.8 EX DC OS HSM
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Federal scientists say they have tentatively identified the mysterious orange goo that showed up recently in a lagoon near Kivalina. It appears to be a concentration of microscopic eggs.
Jeep Rice, research biologist at the Ted Stevens Marine Institute in Auke Bay, says their lab staff first tried to figure if it was plant, animal, or mineral. Several chemists were called in after the samepls arrived Saturday because of concerns that the substance may be some form of chemical pollution. But Rice says the chemists weren't needed once they spotted the basic egg structure under a high powered microscope.
"They're down in the micron range," says Rice. "A herring egg would be a thousand microns. So (these eggs are) down in the one to ten microns, maybe larger. They're very, very small."
Since the eggs are so small and their internal features are very hard to distinquish, it's unclear what laid the eggs. Rice suspects some sort of invertebrate, perhaps a crustacean like a copepod. But Rice says it's hard to tell for sure.
The orange color of the goo seems to come from a lipid oil droplet in the center of each egg.
The eggs that were collected for sampling either dried up or died despite being refrigerated for transport.
Area residents were concerned earlier this month when the never-before-seen substance showed up. Rice says it's possible the eggs just happened to concentrate in that lagoon because of wind or tidal action.
Even though the goo was determined to be natural, Rice would advise against eating or consuming the eggs. There's a remote possibility they could be toxic in some form.
Recent headlines
Timber bill signed, but will it make a difference?Gov. Bill Walker has signed legislation he says will provide more timber for Alaska's mills. But it probably won't be that much of an increase.
Alaska's first Zika case is in SitkaThe state department of Health and Social Services announced the first known case of the Zika virus in the state July 22, belonging to a patient treated at SEARHC's Mt. Edgcumbe Hospital in Sitka.
The year Bristol Bay landed its 2 billionth salmonBristol Bay is home to the largest sockeye salmon fishery in the world. The 2 billionth salmon was landed sometime, by someone, on July 6, 2016.
Supreme Court overturns abortion parental-notification lawThe Alaska Supreme Court overturned the state's parental notification law for minors who are seeking abortions.


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Sometimes to build better software you have to challenge long-standing assumptions. Find out what happened when one programmer realized his priorities were upside-down.
Better Software Magazine Archive:
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April 2004
|Excel Can Be Hell For Test Management and Documentation | QA Symphony
|The Enterprise Guide to Evaluating Agile Software Testing Tools | QA Symphony
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|2015–2016 State of the Software Testing Profession | TechWell


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TesseracT NA tour
glad theres two articles for this they deserve it
Well I got in first with the actual writing but a contributor also did one afterwards but his got published straight away.
Digging: Ghost Hall - Wavelengths
Playing in every state around me
hey I feel ya. I live in South Dakota haha.
Well...found my next concert to go see
Edmonton! It's been a few years, I'll finally have the chance to see them.
Will have to make the trip to Philly, or NY. Alone more than likely :'( but I simply can't miss this.
• Michael Gira Accused of Rape• R.I.P. Lemmy• R.I.P. David Bowie• Scott Weiland dead at 48 • The Story So Far's vocalist dropk..• Rush drummer retires• Killswitch Engage debut new single• Brand new Brand New Single• Deftones stream new single• Riverside guitarist dies
• Operation: Mindcrime New Song• New Betraying The Martyrs Vid• New Silverstein Video• Evergrey release a new single• Mika Bleu Dies• Oathbreaker new album and song• Helms Alee premiere new song• DGD to board the Mothership• clipping. announce new album• New Glass Animals Track• Coroner Enter Studio• Alcest unveil Kodama• First Joy Opposites (ex-FACT) • New Father John Misty single• 40 Watt Sun Album Announced» see all news
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National Girl Scout Cookie Day is Friday. Girls are asking cookie lovers to buy or order more boxes in honor of their success in running the largest girl-led business enterprise in the world. Girl Scout Council of the Southern Appalachians troops earned more than a million dollars for their troop treasuries in 2012.
The Girl Scouts of the Southern Appalachians will be taking orders in person through Feb. 10 and online reservations at IWantCookies.org.
Cookie fans are invited to stop by the Girl Scout office at 1936 Dayton Boulevard in Chattanooga between 8:30 a.m. and 4:30 p.m. for free cookie samples. Meanwhile, Girl Scouts dressed in cookie costumes and twirling signs will also be giving out cookie samples to the lunch crowd at the Frazier Avenue-River Street Shopping Complex from 11:45 a.m.-12:45 p.m.
Home-schooled Girl Scouts will hit the road in a decorated cookie caravan to ride along a Meals on Wheels route, delivering cookies and smiles to meal recipients from 9:30-11:30 a.m. This is expected to be the most special part of the day, and the council is excited to partner with Meals on Wheels. The Girl Scout Mission is to build girls of courage, confidence, and charter, who make the world a better place.
Girls will also deliver milk and cookies to volunteers at the American Red Cross from 8:40-9 a.m. and look inside an emergency response vehicle. They will bring milk and cookies to the staff and volunteers at the McKamey Animal Care and Adoption Center from 2-2:30 p.m. and get a shelter tour.
Follow the fun on facebook.com/GSCSA or on Twitter (@GirlScoutCSA). Girl Scouts will be posting photos from every stop along the caravan. People who don't know Girl Scouts are invited to tweet IWantCookies.org as a way to reserve cookies.
The Girl Scout Cookie Program helps girls build skills for life. According to a survey from the Girl Scout Research Institute, 85 percent of Girl Scout "cookie entrepreneurs" learn money management by developing budgets, taking cookie orders, and handling customers' money. Eighty-three percent build business ethics; 80 percent learn goal setting; 77 percent improve decision making; and 75 percent develop people skills.
All the revenue earned from cookie activities—every penny after paying the baker—stays with the local Girl Scout Council of the Southern Appalachians.
The Girl Scout Council of the Southern Appalachians covers 46 counties from Southwest Virginia, through all of East Tennessee, and into North Georgia with the support of United Way and Community Chest organizations. Its mission is to build girls of courage, confidence, and character, who make the world a better place.
July 22, 2016
Chattanooga Speaks, founded by Main Street Innovations, invites the public to join a free discussion panel to be held at The Camp House on Tuesday from 6-8:30 p.m. about race, culture and community. ... (click for more)
Weekly Roadway Activity Report for TDOT Region 2 (Parts of East and Middle Tennessee) July 21 – July 27 Construction Projects Maintenance / Regionwide / On-Call / Multi-County Contracts ... (click for more)
Local clergy, resident leaders, community activists and business leaders will host a community march, townhall meeting, and worship service next Thursday and Friday. Participants will ... (click for more)
Chattanooga Speaks, founded by Main Street Innovations, invites the public to join a free discussion panel to be held at The Camp House on Tuesday from 6-8:30 p.m. about race, culture and community. "Events across the nation, and our city, are causing communities to come together and be solution orientated in the areas of race and equality. Not all people are doing this in a ... (click for more)
Weekly Roadway Activity Report for TDOT Region 2 (Parts of East and Middle Tennessee) July 21 – July 27 Construction Projects Maintenance / Regionwide / On-Call / Multi-County Contracts Bledsoe County, SR-30 slide repair project near log mile 7.5: Work on this project continues. The contract includes excavating, stabilizing and rebuilding the road ... (click for more)
A 30-year-old Hixson man has been charged with making threats to kill General Sessions Court Judge Lila Statom after police said they found evidence to tie him to recent threats against the judge. David Lee Graham, of 1730 Colorado St., is charged with retaliation against a judge. His bond was raised to $100,000. Detective Ric Whaley said he had been conducting an investigation ... (click for more)
Brandon Jamal Appleberry, 27, was arrested on Monday after an altercation with an employee at Southside Grocery on West 38 th Street, officers said. Marty Witt, 44, told police that the suspect confronted him with a gun in his hand. Officers said security video from the store clearly showed Appleberry arguing with several people outside while holding a gun. The defendant ... (click for more)
It's concerning that the Republican Party elite attending the recent convention would indict, convict and jail a political opponent, when the FBI found no criminal intent to compromise national security and no other law violations were found. This "lock her up" mob mentality is third world, over-the-edge behavior that has no place in a country based on the rule-of-law, where ... (click for more)
Back when we were kids the old guys taught us how to throw a one-two punch. It's pretty impressive if you do it right, which is to jab your left fist into the thug's face and then, as though it was a symphony, complete the combination as you deliver a powerful right cross to the same nose. If the thug has a gun, it doesn't work as well. But, boy, did our community ever get clobbered ... (click for more)


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Capture exceptions, uncaught errors, and custom events into your kontrol.io dashboard.
Fix for Disqus count.js 'split' error.
Detect fatal errors that might be produced by the installed active Plugins, provide secure backdoor for deactivating the target Plugin.
Fixes a fatal error message on the dashboard.
Quelques vidéos d'erreur 404 de Dailymotion à ajouter à votre page "404 Not Found" !
Enables a completely customizable WordPress login, registration and password form.
Plugin for integration with Buggyman.io tool for monitoring of your PHP & Javascript errors and exceptions
Here is a short description of the plugin. This should be no more than 150 chars. No markup here.
This plugin add new option in you blog for use in 404 page. This is
Basic Developer Tools helps developers to log any variable, error or exception of which they need the value, without bloating their live environment.
Logs errors with full information to an Elastik Ticket System. Errors can be tracked and emails can be sent to devs from there.
Monitor your website, plugins and themes.
Sends public sites with the XHTML mime type. The internal sites, which have many XHTML errors, are still sent with the HTML mime type.