text:
The HOW MANY People WILL YOU FUCK? Test
Their result for The HOW MANY People WILL YOU FUCK? Test ...
40 Future Partners!!
Your Meaningless Percentage is ###%!
Their Analysis (Vertical line = Average)
They scored 62% on FUCK, higher than 45% of your peers.
All possible test results
-4 Future Partners!!
Negative 4 partners! Well, CONGRATULATIONS BUDDY! You may be wondering how it's even possible to have -4 partners. Well, so am I. I don't write the tests, I just channel 'em. Maybe it means 4 people w... Read more
0 Future Partners!!!
Well we don't have to worry about over-population with people like YOU around... You probably have a small penis or a big vagina. Maybe you're something ridiculous like a priest or a virgin or ringo. ... Read more
1 Future Partner!!!!
See the picture? Probably not because you've gone blind from masturbatory-related activities. But if you look at the picture carefully you'll see how you're going to get your only future partner. Pret... Read more
3 Future Partners!!
You will have 3 future partners in your lifetime. The odds of having sex with them all at the same time are 10,317 to 1. Considering the human world only has 9 years left anyways, you should expect a ... Read more
7 Future Partners!!
You're probably thinking what I'm thinking, 7's just not quite enough... At least they'll be all at once. Yep, you heard me right, your 1st 8-some! Too bad they will all have poison ivy, and liver dis... Read more
20 Future Partners!!
Well you have what your semi-humble testwriter thinks of as just barely not enough future sex partners... My suggestion to you would be to maximize them... Get a rotation going on possibly, maybe some... Read more
40 Future Partners!!
Allright! 40! You have just barely enough sex partners in your destiny. Hopefully you can get them all in a room and see what happens. Of couse you do realize that with this many partners, the tawtnes... Read more
75 Future Partners!
75 future partners. Pretty Neat, Huh? Well, if you feel good about these test resluts, i mean results, you have only me to thank, your extremely humble-ass testwriter. But back to you, 75. 75. Damn. F... Read more
100 Future Partners!
Well, that's fairly impressive, now. 100 crazy partners. You are in the highest realistic category. If you lied to get here, it still counts, because when it comes to the dating game, 1/2 of it's what... Read more
500 Future Partners!
500 partners. Jesus. H. Whatnot. You're gonna have sex with 500 lepers. I mean partners. You ought to be my wingman if you are a man (or my whatever if you're not). 500. Oh well, at least this frigcks... Read more
999999+ Sex Partners
I just don't know what to say. You are in the highest category. You're gonna funk over a million people before you die. I hope you're young, because this is going to be a time-consuming (though lucrat... Read more
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Random Network Reviews: WrestleMania XXWrestleMania XX March 14th, 2004 | Madison Square Garden in New York, New York | Attendance: 18,000 This is a pretty historic WrestleMania, but due to one obvious thing that happened in 2007, it won't held in very high esteem when it comes to ... 411mania.com, 2 weeks ago
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subset: commoncrawl


text:
« Perthshire, Angus & Dundee - Home
Activities in Perthshire, Angus & Dundee
Aberfeldy, Perthshire, PH15 2BH
Tricky 18 hole course in parkland on the banks of the River Tay.
Ferntower Road, Crieff, Perthshire, PH7 3LQ
Action Glen is Scotland 's Premier Adventure Centre based in Crieff, Perthshire. Offering over 40 on-site activities, you…
Invergowrie, by Dundee, DD2 5LP
At Piperdam we have both a 9 and 18 hole course to suit all levels of ability.
Heatheryford, Kinross, KY13 0NQ
We have four fish ponds locate in beautiful surroundings.
Clocksbriggs, by Forfar, Angus, DD8 2TD
An attractive 200 acre loch stocked with hard fighting rainbow and brown trout. Bank or boat fishing.
Perthshire, Scotland, UK
This good salmon and sea trout river runs 50 miles from Loch Earn to the sea. Fishes best in September-October. Excellent...
Coupar Angus, Perth and Kinross, Scotland, UK
This tributary of the River Tay also offers a productive salmon river with good brown trout and grayling fishing.
Kenmore, Aberfeldy, Perthshire, PH15 2HN
Undulating 9 hole parkland course suitable for all standards with excellent facilities.
Dundee, DD9 7TF
You haven't played paintball until you've played Bedlam Paintball.
Lochearnhead, Perthshire, FK19 8PZ
This six mile long loch is well known for its trout fishing, also ferox, arctic charr and occasional sea trout. Boats for...
Coupar Angus Road, Dundee, DD2 4TF
Beautiful championship golf course is located within the magnificent leafy estate of Camperdown Country Park.
Perthshire, Scotland, UK
This tributary of the River Tay offers salmon, brown trout, grayling and the occasional sea trout. Best fishing is...
Butterstone, Nr. Dunkeld, Perthshire, PH8 0HH
Where better to discover the pleasure of Scottish fly fishing than the scenic Butterstone Loch?
Bridge of Balgie, Glen Lyon, Perthshire, PH15 2PT
Guided walking holidays and courses all over Scotland
|Aberfeldy Golf Club
|Aberfeldy, Perthshire, PH15 2BH
|Action Glen - Scotland's premier adventure centre
|Ferntower Road, Crieff, Perthshire, PH7 3LQ
|Segway Ecosse
|Blair Atholl, PH18 5SR
|Piperdam Golf Courses
|Invergowrie, by Dundee, DD2 5LP
|Kinross Trout Fishery
|Heatheryford, Kinross, KY13 0NQ
|Rescobie Loch
|Clocksbriggs, by Forfar, Angus, DD8 2TD
|River Earn
|Perthshire, Scotland, UK
|River Isla
|Coupar Angus, Perth and Kinross, Scotland, UK
|Mains of Taymouth Golf Course
|Kenmore, Aberfeldy, Perthshire, PH15 2HN
|Bedlam Paintball (Edzell)
|Dundee, DD9 7TF
|Loch Earn
|Lochearnhead, Perthshire, FK19 8PZ
|Camperdown Golf Course
|Coupar Angus Road, Dundee, DD2 4TF
|River Tummel
|Perthshire, Scotland, UK
|Butterstone Loch Fishings
|Butterstone, Nr. Dunkeld, Perthshire, PH8 0HH
|Explore Outdoors
|Bridge of Balgie, Glen Lyon, Perthshire, PH15 2PT
Click the map pins to view more information.


text:
Possible Answer
Malta, Where Suleiman Laid Siege BY JUDITH MILLER; Judith Miller is a correspondent in the Paris bureau... - read more
World news about Malta. Breaking news and archival information about its people, politics and economy... - read more
Please vote if the answer you were given helped you or not, thats the best way to improve our algorithm. You can also submit an answer or search documents about times of malta obituaries.


text:
I just felt like recording my gaping loose sissy hole. I love to fuck my sissy ass pussy. I love toying and fisting. Love to show, display my *****d swollen gaping sissy hole. Sometimes have my *****friend video my sissy ass fisting with her. She does a good job, now the ***** is getting her to talk dirty.
- Runtime:
- 1:56
- Views:
- 49917
- Date:
- 5 years ago
- Rating:
- (25 votes) 93%


text:
needs more dragons
Type: Posts; User: ChromaticCodex; Keyword(s):
needs more dragons
Your environments and compositions are looking nice! Good work with lighting and emphasis as well. Glad to see your playing with texture so much, good stuff. Something about the form of figures...
Nice work! your paintings have great energy and variety of textures, very fun stuff to look at :P
Misty Feather- Thanks for the complements, hopefully I was of some help :)
COW Final: wish i had more time as usual but, jumped in late. Had to scrap my background ideas to get it done in time
Artist: Chromaticcodex
Concept: Melanistic Five-headed Dragon
Scourge: Killing it as usual. Took me a second to realize your dragon is fishing :D Such amazing textures!
Mike: sexy pencils! can't wait to see it finished. The...
Hoping to get this done by the deadline, just started last night.
Trying to get this done quick D: figure i'd make a step-by-step since i've never posted one. Looking good Rob, tight rendering on those dragon heads, gives nice emphasis.
I still have much to do...
I second that: keep up the good work! Much potential! Very art!
For anatomy stuff, you might really benefit from drawing some skeletons and musculature. Your starting to get a hang on the surface...
Good point about defiled visions. He would clean up! I'm a dragon-o-phile as well. Going to be a late start but maybe I can get something presentable ready! Got a bit of a hand injury :(...
Retep! Good to hear from you, as you can tell by how much time has elapsed I'm not on here too often either... I'll keep an eye out for updates on your blog though. I love your artwork as always...
portrait of Reggie Watts
self portrait may on 30th
Gorgeous work! I have nothing constructive to say, so let me just say THANKYOU! I'm blown away. Compelling stuff! You've definitely earned that banner spot :)
My first stab at making a sprite. Watch for about 10 seconds minimum :)
I like the stuff in post 18, looks like your doing some good observation there. I'd say practice from life all you can. Jump on any and all chances to do figure drawings, practice gesture drawing,...
As had been said already: nice colors! The faces you've drawn look nicely constructed, but there bodies seem flatter and less confident. Also, I don't personally like the black lines in image on...
bbwolf: Thanks for stopping by. I miss George Carlin too :( and Bill Hicks...
LoudLikeNature: Thanks so much for the feedback. Your totally right about my color use! I just love bright...
Album cover for a crazy sounding folk band. I had tons of fun working on this
I had no directions given on this one, had a lot of fun.
Really like post #12.. looks like you were... having fun!! You've got some nice gesture and confidence in those little figures. Your larger more polished stuff feels a little more forced. Try and...
Scourge: The creature on the far left takes the cake out of this batch! very cool asymmetrical design, variety in the forms and details is interesting, and my favorite palette of the 4
Thanks Eofn! Just saw your reply after posting my idea. I'll try to make my characters look more like they're in charge of something.
Developed Actively by vBSocial.com


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Payment Protection
from £31 / night help Price for guests, Nights
Casa Antonella Apartment
- 1 bedroom
- 4 sleeps
- min stay varies
Casa Antonella
- Apartment
- 1 bedroom
- 4 sleeps
- min stay varies
Description from owner
Casa Antonella offer simple yet comfortable self-catering accommodation in Lipari, the largest island in Sicily's stunning Aeolian Islands. There is a delightful one-bedroom apartment (45m2, sleeps up to 4), with a double bedroom and a double sofa bed in the sitting room (an extra bed can be added if required). A private bathroom, fully equipped kitchen, air-conditioning, TV, and hairdryer. The house has a balcony that overlooks a quiet alley characteristic.
Key Info
- Beach / lakeside relaxation
- Nearest beach 3 km
- Great for children of all ages
- Car not necessary
- Air conditioning
- Some pets are welcome - please contact the owner
- Great for children of all ages
- Some pets are welcome - please contact the owner
Bed & bathroom
- 1 Double Bed, 1 Sofa Bed
- 1 Family bathroom
- Wi-Fi available
- Air conditioning
- Internet access
- Central heating
- Cooker
- Fridge
- Freezer
- Iron
- Hair dryer
- Linen provided
- Towels provided
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- Not suitable for wheelchair users
- Payment
- This rental can only be paid for online through Holiday Lettings using your credit/debit card or PayPal (never by bank or wire transfer).
- Smoking
- Yes, smoking allowed
- Cancellation policy
View Policy
About the owner
Giuseppe G
- Response rate:
- 75%
- Calendar updated:
- 27 Jul 2016
Languages spoken: English, French, Italian
This Apartment has 1 bedroom, 1 bathroom and sleeps 4. It's been listed on Holiday Lettings since 28 May 2013. Located in Aeolian Islands, it has 1 review with an overall rating of 4. The average weekly rate varies from £750 to £925.
The Owner has a response rate of 75% and the property's calendar was last updated on 27 Jul 2016.
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text:
Ross Perot Jr., the Founder & CEO of Alliance Texas, joined David Johnson for today's KRLD CEO spotlight.
Today's 'Your Hometown' Tour is in Northeast Tarrant County, where Perot continues to develop a number of projects.
Latest News:
- Police: Lawyer, 32, Charged With Indecency With Child
- Mesquite PD Announces "Back The Blue, Bring A Book" Campaign
- UNT Hires New Athletic Director
- An "Unprecedented Surge" In Dallas Police Applications
- Shippy & Luds: In The 5 Hole: Kris Russell Discussion & Twitter Questions Answered
Top Trending:


text:
November 10, 2012 6:21:31 PM
Soprano Alisa Toy will present her senior voice recital Tuesday, Nov. 13, at 7:30 p.m. in the recently renovated Poindexter Hall at Mississippi University for Women.
Toy is a music education major and the wife of Dr. Royal Toy, education professor. She will be accompanied by MUW alumna Rachel Delk.
The program will begin with Gioachino Rossini's showpiece "La Regata Veneziana" that describes a Venetian boat race. After a section of German and French art songs, a highlight of the program is a comic duet from Mozart's "Don Giovanni" with Royal Toy, baritone. Juliet's famous waltz aria from "Romeo and Juliet" by Gounod will follow the duet. Concluding the recital is a set of songs by contemporary American composer Ben Moore.
Toy recently won first place in regional and state student auditions of the National Association of Teachers of Singing and is a student of Dr. Cherry Dunn, MUW professor of music.
The recital is free and open to the public.
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1. GTHR on a mission: placing healthy horses with loving homes COMMUNITY
2. 4-H Shooting Sports competitors go to state, national events COMMUNITY
3. Local voices: From Mississippi to Manhattan COLUMNS
4. MSU Riley Center new season lineup touts some big names ENTERTAINMENT
5. Being Beautiful: Memories of a boy and his bike COLUMNS


text:
Courtney Walker scored 21 points as No. 17 Texas A&M won its ninth straight game and remained undefeated in conference play with a 62-57 win over Missouri on Thursday night.
After trailing for much of the first half and 33-31 at halftime, Texas A&M (16-4, 6-0 SEC)took the lead early in the second and never relinquished it.
The Tigers (13-6, 2-4) hung around though and cut their deficit to 60-56 with 1:15 to play. Missouri then got the ball back after a missed 3-pointer by Texas A&M but the Tigers missed 3s on their next two possessions and the Aggies prevailed.
Courtney Williams added 14 points and went 6 of 11 from the field for Texas A&M.
Morgan Eye led Missouri with 19 points while Brianna Kulas added 14 points and 11 rebounds for the Tigers, who have lost four of their last five.
Missouri Tigers women's basketball fall to No. 17 Texas A&M 62-57
Courtney Walker scored 21 points as No. 17 Texas A&M won its ninth straight game and remained undefeated in conference play with a 62-57 win over Missouri on Thursday night.
Copyright © 2014 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Hartsburg man arrested for threatening family member with a gun
Gov. Nixon responds to public defenders lawsuit over withholding
Boat explodes at Lake of the Ozarks, one person hurt
Columbia Fire Department confirms structure fire at North Providence and Fourth Ave.
DNC day two speakers hint at issues party will address Tuesday
Historic political donation comes from obscure source
Road buckle shuts down neighborhood street in southwest Columbia
Protests break out in Philadelphia on eve of the Democratic National Convention
9 tourist attractions that are crumbling down
Biggest opening weekends for movies


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Fried Oreos
Total Time
Prep 5 mins
Cook 15 mins
Okay, I know this is strange but it is in response to a request on the boards. Actually looks interesting and if you're going to blow calories on Oreos why not have them deep fried to boot? :)
Ingredients Nutrition
- Preheat deep fryer to 375 degrees F.
- Combine pancake mix, milk, eggs and oil.
- Mix until there are no lumps.
- Dip Oreos into batter, make sure both sides are covered and put the Oreos into the deep fryer.
- You will need to watch these as the cookies tend to float- so be sure to turn them.
- Also be careful that they don't burn- you just want them golden brown.
- Remove the cookies and drain well.
- The cookies are best straight out of the deep fryer!
Most Helpful
These are the best when i first tried them my mouth just started watering and sprinkle the powdered sugar on top it put it heaven.
These are delicious! As a personal touch I sprinkle powdered sugar on top. Like Mysterygirl said, "if you're going to blow calories" Hehe
These are yummy. I used Hungry Jack Just add water pancake mix and they turned out great. I also tried them using the Golden oreos and they were just as good! YUMMMM


text:
Even though we ARE Nikon lovers,we are NOT affiliated with Nikon Corp. in any way.
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Manila,, PH
442 posts
Hi guys, I have long wanted to get a medium format camera but it's only recently that I happened to get a mint Mamiya RB67 Pro S with a 65 4.5 lens and 120 back at US$ 400. I have tried on several occassions my friend's Mamiya 645 but not really on a regular basis. I choose the RB67 because I can still use a 645 back and I like the frame better than a 645.I wil start using the RB this weekend and I have some questions; I weighed the RB w/ lens and it's about 4+ pounds and I don't own a real good sturdy ballhead, will I get good results using slik pro 814 CF tripod and manfrotto pistol grip which can handle 8 lbs? I understand the mirror slap of the RB is quite hard and vibrates. I do plan to order the accratech balhead but delivery will probably be long so I want to use what I have as of now. Another question is what woul be the next best lens that I can buy? I only intend to get one at this time, I will shoot landscape, sunset/sunrise and some portrait. I want the sun not to be too small in the frame so maybe a 180 or 250 will be better. Any other useful tips on using this beast will help a lot on my learning curve.Btw, as of now I can only get the Ektachrome 160 pro, Tri Max 400 and CN400 B&W on a 120 film roll.
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Colorado Springs, US
16920 posts
#1. "RE: Mamiya RB 67" | In response to Reply # 0
That's a very good deal on an RB67. I'm not intimately familiar with those tripod components, but it's my experience that you don't want to come near the load limits. I think a 180mm would be a great choice as a second lens. It should complement your 65mm well and is a good choice for tighter landscape shots and portraits.A few tips:- Try to locate a dual cable release so that you can easily lock-up the mirror just before shooting. That will eliminate the issue of mirror slap. If you can't find a dual cable release, get two inexpensive standard cable releases.- Hyperfocal distance focusing and depth of field calculations are a bit tough with the RB67 because the scale is so imprecise and hard to read on the body. Carrying a hyperfocal card and focusing on something that's approximately at the same distance as the hyperfocal distance is easier in my opinion.- Don't be tempted to skip the tripod. The RB67 is a big enough beast that handholding won't bring out the best it can deliver.Enjoy the RB67. You can get some beautiful results with it.
Rick WalkerMy photos:GeoVista Photography
#2. "RE: Mamiya RB 67" | In response to Reply # 1
Thanks for the tip Rick, I already have a shutter release cable for my Nikon manual cams and I can use that to trip the shutter, I guess I will have to get a 2nd cable for the mirror up though I can manually bring it up in the meantime. yes, I will get the 180 1st then a 50 later. Wow this excites me a lot thinking that I will get to try it this weekend.
606 posts
#3. "RE: Mamiya RB 67" | In response to Reply # 2
I got the rz pro II and it weighs in at around 5 lbs with the 110 2.8 lens. I found this thread and the recs dead-on with the monopod rec and link:http://www.photo.net/bboard/q-and-a-fetch-msg?msg_id=00FLmcI got the 180 and love it-- pretty much an 85mm on 35mm.enjoy-- great price!
-----"A fool sees not the same tree that a wise man sees." -William Blake http://fstopstudios.blogspot.com
#4. "RE: Mamiya RB 67" | In response to Reply # 3
>I got the rz pro II and it weighs in at around 5 lbs with >the 110 2.8 lens. I found this thread and the recs dead-on >with the monopod rec and link: >>http://www.photo.net/bboard/q-and-a-fetch-msg?msg_id=00FLmc >>I got the 180 and love it-- pretty much an 85mm on 35mm. >>enjoy-- great price! That was great discussion, thanks so much. Just wonering about the optics of 180, is it the same with the older versions?
#10. "RE: Mamiya RB 67" | In response to Reply # 4
This is the beautiful beast I traded my F100 with .......Pro-S model with 120 film back and 65 4.5 lens .......I just ordered the 180 4.5 Sekkor C at $ 239 ....just can't forget the 1st roll of slide using ektachrome 100 .....wonder why I have not bought one before..
#5. "RE: Mamiya RB 67" | In response to Reply # 10
That's a beauty! You'll love the 180-- just about the perfect lens for studio!I felt/feel the same way-- at these prices, I'm glad everyone ran out and went digital
#6. "RE: Mamiya RB 67" | In response to Reply # 5
It's a great time to buy medium format stuff. I've definitely benefited from the "jump to digital" recently.
#7. "RE: Mamiya RB 67" | In response to Reply # 6
Thanks, yes it's really a bargain considering the condition and the "jump to digitasl" has made this a reality. I used it again yesterday I have a question, when you use the T mode and mentally count the time of exposure how do you close the shutter. I tried tripping it again but no reaction, I closed the MLU and seems that the sound is only for the mirror going down, I also tried cahnging the shutter after the seposure to 1 second but still I can't feel the shutter closing down. Am I doing it wrong? What should be the procedure? Thanks again.....
#8. "RE: Mamiya RB 67" | In response to Reply # 7
Turning the shutter speed dial to one second should close the shutter. Alternatively, you can press down the shutter cocking lever a bit. Keep in mind that the leaf shutter is extremely quiet and jar-free. The RB67 doesn't have an instant return mirror, so there's no obvious "clunk" when the shutter closes. If you're not certain it's closing, do a test shot without film and look in through the lens. You should see the shutter open and close.
#9. "RE: Mamiya RB 67" | In response to Reply # 8
Thanks again Rick, I'll try that.
Leeds, UK
339 posts
#11. "RE: Mamiya RB 67" | In response to Reply # 9
Hi Gil Well first off Welcome to the RB67 ClubBack to a proper camera This Link may help youhttp://www.mamiya.com/assets/pdfs/6x7/RB67_Pro-S_v7.pdfYou certainly look like you have got a bargainYou will find the learning curb frusting so be prepared to loose a few filmsThe RB67 pro s has a few safety factors but once you get used to them they become no problem With regard to the T setting when you reset the level half way it shuts the shutter read the manualHave Fun Ps Regarding weight the RB67 with a 90/127 lens and 120back is about as much as a D300 with a 24-70 lens !!!!Regards FUJS5


text:
PRO Research
Sorrento Therapeutics: Has The Potential To Become Next Abraxis
Grant Zeng, CFA
Grant Zeng, CFA
Mon, Jul. 11, 10:19 AM
- Sorrento Therapeutics (SRNE -0.3%) closes a license and collaboration agreement with French drug maker Servier for the development, manufacture and commercialization of Sorrento's IND-stage STI-A1110, a fully human immuno-oncology anti-PD-1 monoclonal antibody.
- Under the terms of the deal, Sorrento will receive an upfront payment of €25M, milestones up to €710M and high single-digit to double-digit royalties on net sales.
Mon, May 16, 10:44 AM
- Mabtech Ltd., a biosimilar development and commercialization partner with Sorrento Therapeutics (SRNE +3.1%), completes a successful Phase 2/3 clinical trial in China assessing Sorrento's STI-004, a biosimilar antibody of Roche (OTCQX:RHHBY +0.8%) and Novartis' (NVX +0.2%) asthma and urticaria med Xolair (omalizumab).
- STI-004 is one of four monoclonal antibodies licensed by Sorrento from Mabtech last year for the territories of North America, Europe and Japan.
- Previously: Sorrento inks biosimilar antibody deal with China's Mabtech (Aug. 3, 2015)
Mon, May 16, 9:19 AM
Mon, May 9, 1:12 PM
- Thinly traded micro cap Sorrento Therapeutics (SRNE +7.2%) announces that, earlier this year, it engaged Guggenheim Securities and PJT Partners to assist it in assessing strategic alternatives to maximize shareholder value.
- The company has no definite timeline for any type of deal and says there is a possibility of no deal at all. It does not intend to disclose any further information on the matter until such time as a material event warrants such disclosure.
- The company's oncology pipeline includes six monoclonal antibodies and five CAR-T programs.
Wed, Apr. 6, 9:06 AM| Wed, Apr. 6, 9:06 AM
Tue, Apr. 5, 7:12 AM
- Sorrento Therapeutics (NASDAQ:SRNE) enters into definitive agreements with institutional investors and its strategic corporate partner, Yuhan Corp. of South Korea, for the private placement of ~$150M of newly issued common stock at $5.55 per share and warrants to purchase common stock at $8.50 per share.
- Net proceeds will fund pipeline development and general corporate purposes.
- Yesterday's close was $6.30.
- Read now Sorrento Therapeutics Bottoming At $5 To $6 Per Share And Offering Material Upside
Wed, Mar. 2, 10:22 AM
- Sorrento Therapeutics (SRNE +4.4%) and South Korean pharma firm Yuhan form a joint venture company, ImmuneOncia Therapeutics, LLC, to develop and commercialize immune checkpoint inhibitors against undisclosed targets in certain blood cancers and solid tumors.
- Under the terms of the agreement, Yuhan will make an initial investment of $10M and Sorrento will grant ImmuneOncia an exclusive license to one of its immune checkpoint antibodies for selected territories exclusive of the U.S., Europe and Japan. The JV will also have global rights to two additional antibodies that will be selected by ImmuneOncia from Sorrento's portfolio.
- Yuhan will own 51% of ImmuneOncia while Sorrento will own 49%. Yuhan Chief Scientific Officer Dr. Su Youn Nam will lead the venture as CEO.
- The first of the three immune checkpoint antibodies should enter clinical trials in 2017.
Tue, Jan. 12, 8:33 AM
- Cellectis S.A. (NASDAQ:CLLS) is up 9% premarket on light volume in response to the news that it has developed a new chimeric antigen receptor (CAR) architecture that permits control over CAR-T cell functions, potentially enabling the ability to control unwanted risks such a cytokine-release syndrome and "on-target, off-tumor" effect. Currently, the only remedies for these effects rely on suicide mechanisms that completely eradicate the engineered T-cells which results in a premature end of the treatment.
- Cellectis scientists engineered a system directly integrated with the CAR architecture by adding a small molecule that turns a CAR-T cell from an "off" state to an "on" state, thereby controlling activation and mitigating the risk of CAR-induced toxicities. It also creates opportunities for spatial activation of the engineered CAR-T cells using local targeted drug delivery.
- The study was just published in the journal Scientific Reports.
- Related tickers: (NASDAQ:JUNO)(NASDAQ:KITE)(NASDAQ:BLUE)(NASDAQ:BLCM)(NYSE:NVS)(NASDAQ:SRNE)
Dec. 22, 2015, 12:50 PM
- Thinly traded micro cap Sorrento Therapeutics (SRNE +16.4%) shows some pep in early trading on triple normal volume. The only news is the initiation of coverage by FBR capital with an Outperform rating and $22 (142% upside) price target.
- The company is developing a range of monoclonal antibodies and immuno-oncology therapies. Its one of many in the universe of Dr. Patrick Soon-Shiong, who became famous after he founded and sold Abraxis BioScience to Celgene for $3B in 2010.
Oct. 19, 2015, 7:05 AM
- Sorrento Therapeutics (NASDAQ:SRNE) appoints Jeffrey Su, Ph.D., as EVP and Chief Operating Officer. He joins the firm from Cytovance Biologics where he was Chief Scientific and Development Officer.
Aug. 10, 2015, 10:52 AM
- Sorrento Therapeutics (SRNE +1.7%) subsidiary TNK Therapeutics acquires multiple preclinical and clinical stage chimeric antigen receptor (CAR)-T immunotherapy programs in addition to the underlying CAR-T technology from two undisclosed privately-held biotech firms. The programs target solid tumors as well as infectious diseases.
- The transaction enables TNK to accelerate the development of in-house adoptive immunotherapies, including the off-the-shelf" CAR.TNK, programs, with partner NantKwest (NASDAQ:NK).
- Sorrento will provide additional information about the CAR-T programs, the underlying technology and biosimilar/biobetter antibodies in an updated corporate presentation later this month.
- Financial terms of the deal are undisclosed.
Aug. 3, 2015, 1:46 PM
- Sorrento Therapeutics (SRNE +0.9%) enters into an exclusive license agreement with China-based Mabtech to develop and commercialize multiple prespecified and undisclosed biosimilar or biobetter antibodies. Under the terms of the agreement, Sorrento will develop and market four monoclonal antibodies for the North American, European and Japanese markets.
- Each product candidate has completed a Phase 3 trial, two are currently under regulatory review in China and two are under data analyses in preparation for regulatory filings in China. The four represent a $13B+ global market.
- Specific financial terms of the deal are not disclosed.
Jul. 28, 2015, 12:40 PM
Jul. 28, 2015, 12:34 PM
- NantKwest (NASDAQ:NK) is up a respectable 33% on its first day of trading. Turnover is over 7M shares.
- Investors may have expected a more robust first day pop. They appear to be taking their disappointment out on NantWorks collaborator Sorrento Therapeutics (SRNE -12.2%). Shares are off on double normal volume.
Jul. 20, 2015, 6:47 AM| Jul. 20, 2015, 6:47 AM
Jul. 9, 2015, 11:13 AM
- Sorrento Therapeutics (SRNE +5.2%) and NantWorks subsidiary NantBioScience establish a joint venture to develop small molecules against cancer targets that remain illusive for drug developers. Sorrento will contribute its programs for lead inhibitors of the proto-oncogene c-Myc, the master metabolism regulator HIF-1 alpha and an inducer of the tumor suppressor cytokine TRAIL.
- NantBioScience will own 60% of the JV while Sorrento will own 40%. Funding will reflect this split.
- This JV follows NantPharma's acquisition of the rights to Cynviloq and the formation of NantiBody, a JV to develop immunotherapies.
Company Description
Sorrento Therapeutics, Inc. is a biopharmaceutical company, which engaged in the acquisition, discovery, development and commercialization of proprietary drug therapeutics that address significant unmet medical needs. Its products and technologies have much broader clinical applications... More
Sector: Healthcare
Industry: Biotechnology
Country: United States
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Job Application Tips
Applying for jobs may be an intimidating endeavor, especially if you're a new graduate looking for work out in the "real world" for the first time. Luckily, there are a number of things you can do to make the process less stressful and feel more confident in both your applications to jobs you're interested in and your chances of landing a satisfying position. Take a look at the job application tips we've come up with below to help you land at the top of a potential employer's pile of applicants and get in the door for an interview.
Fine-Tune Your Resume
Your resume is a summary of your professional and academic experiences up to the point of the job you're looking for now. It's a way to show an employer how you communicate your skills and how you market yourself, and gives that employer a picture of the kind of things he or she could expect from you on the job. It is crucial then to make sure this document is as professional and complete as you can make it, as some jobs will only require this one sheet of paper from you before they make a decision on whether to bring you in for an interview.
Your resume should be thorough but succinct. Most recent graduates shouldn't turn one in that is more than one page long unless an employer asks for additional lists of experience. Spend some time making a list of action verbs that describe what you've done in prior jobs, even if those consist of part-time work to pay for school or unpaid internships. Consider the resume a pre-interview. What do you want the employer to know about you? What can you bring to the job? Once you're done and have completed the requisite proofreading, have someone take a look at your resume with a critical eye, whether that's your roommate, a career center counselor, or a former professor. It's easy to skip over a spelling error after you've been staring at a document for hours on end, and such a minor mistake may send the message to a potential employer that you lack an attention to detail.
Follow Instructions
Before you even apply for a job, make sure you read the job description carefully. An incomplete application will surely land you in the rejections pile, so follow instructions as given. If a job description tells you to email your materials, don't assume that mailing them in will lead to a better impression. It'll only show your potential employer or hiring manager that you can't follow directions. The same goes with cover letters or writing samples. Market yourself appropriately, but don't try to oversell. Don't send 10 samples if the description asks for five; you'll appear indecisive rather than ambitious. Don't leave anything blank if you're expected to fill out an application in addition to your resume and cover letter unless it states on the application that leaving non-applicable fields blank is acceptable. Be complete and be neat. And, most importantly, proofread. Make a list of required materials to check off if you're applying for a particularly involved position with a more complicated application process. The materials you send serve as a first impression, so make it count.
Whether a potential employer asks for just a resume or a more involved application complete with writing samples and a cover letter, tweak each packet you send out or email so that they are customized to each job you're applying for. This may mean deleting experiences that are irrelevant to one job but important to another, or sending samples that fit one job better than another. Do your research and include a sentence or two in your cover letter that relates your experiences to the company or organization you're looking to work for. Consider what the employer is looking for in an ideal employee by scanning the job's ad, and highlight the skills and experiences that would meet those expectations. Your efforts will speak volumes to a potential employer who may sift through dozens of applicants at a time.
Employment After College
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July 28, 2016
by Susan DutcaThe University of Wisconsin - Green Bay is offering a course to educate students on the environmental justice movement, and it's titled "Green Lives Matter." From topics of flint lead contamination to migrant farm worker pesticide exposure, the program "argues the effects of capitalism force poor and minority community to live in dangerous and unhealthy situations". If you have a passion [...]
An Underrepresented, Struggling Minority in Higher Education
July 26, 2016
by Susan DutcaNative American students lag behind their peers from a young age, across almost every measure of student success. From college enrollment, to test scores and on-time graduation, they have the lowest rates of any racial subgroup. They make up a mere 1 percent of the high school and college population and tend to be overlooked when it comes to discussion about the nation's achievement [...]
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July 21, 2016
by Susan DutcaColleges and universities across the nation are starting to engage more in discussions regarding what it means to be a man. Masculinity, just like femininity, is celebrated through these gender-specific scholarships. So man-up and check out these scholarship opportunities!: Colored Rocks Contest [...]


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Nayland College's senior A boys basketball team were recognised for their exploits at the annual Nayland Sports awards last week, winning the top prize of the Howat Cup for allround sporting excellence, and the Andrew Trophy for outstanding team performance.
At the South Island secondary schools championships, the team was second after making the final for the third year in a row.
Four weeks later they equalled the best-ever finish in the school's history, finishing fourth in the national competition.
Nathan Dempster and Scott Cameron shared the D'Arcy Cup for best allround sportsman in 2012.
Scott Cameron captained the boys A volleyball team to win the South Island secondary schools title. He was selected in the South Island Schools team and named in the New Zealand Secondary Schools team that won their test against Australia.
In basketball, Scott captained the senior A team that was second in the South Island and fourth in the New Zealand. He was a member of the Nelson under-19 team that was third in New Zealand and is a Nelson Giants development player.
In school athletics, Nathan won the senior athletics championship and was captain of the First XV and Press Cup rugby team and the Nayland sevens team. He captained the Nayland boys squash team to win the Tasman secondary school squash championships and was a valuable member of Nayland's successful basketball and volleyball teams.
Nathan also shared the Gowans Trophy with Brianna Joyes (netball, touch and basketball). The Gowans Trophy is annually awarded to a student or students who, over their period of time at Nayland College, gave an outstanding contribution to sport.
The Monica Robinson Cup for best allround senior sports girl was shared between Sara Reidie and Michaela Matenga.
Sara was captain of the Nayland College senior A basketball and a Nelson/Tasman rep in basketball and netball. Sara was a member of the senior A volleyball team that competed at nationals in New Zealand and Australia. She was selected in the squad of 20 for the New Zealand under-17 team.
Michaela was vice captain for the Nelson under-19 and 21 women's touch teams and was selected in the New Zealand under-19 women's team.
In netball, Michaela captained the senior A netball team; she was named in the South Island Secondary Schools tournament team.
She was named Tasman's under-19 team MVP and made the New Zealand Emerging players development squad.
Winners of the Nayland College Trophy for outstanding junior team performance was the 4x100 metres boys relay team of Jonas Kale, Adam Pulling, Mitchell Chandler, Kelvin Torrance.
The relay team won the under-16 boys South Island title and was fourth in New Zealand.
Riley Haymes was awarded the Olley Cup as the best all-round junior sports boy.
In athletics, Riley won the Tasman under-15 boys 400m title, while in football he played in the New Zealand Nike Cup for Nelson Suburbs and was a member of the Nelson under-15 rep team that was second in the South Island.
Keeper Cup for best all-round junior sports girl went to Holly Chandler. In 2012 Holly represented Nayland College in an impressive eight sports. Holly's national highlights included the South Island under-14 girls javelin title and the New Zealand under-16 Koru basketball team.
The Higginson Cup for sportsmanship, was presented to Sara Eden and Jordan Douglas, recognising qualities such as respect for team-mates, opposition and officials.
Other results:
Athletics: Nayland College Cup for outstanding contribution to girls athletics - Holly Chandler; McKay/Rainey Trophy for outstanding contribution to boys athletics - 4 x 100m junior boys relay team.
Orienteering: Nayland College Cup for outstanding all round contribution to orienteering - Ben Sutton.
Cross Country: Lineham Cup for outstanding allround contribution to cross country - Thomas Andersen.
Squash: Palmer Trophy for the player making the greatest contribution to squash - Nathan Dempster and Ella Orr.
Tennis: Cameron Trophy for the player making the greatest contribution to tennis - Hannah Waine.
Cycling: Nelson Cycling Trophy for best allround season - Olivia Miller and Grayson Napier.
Bowls: Nayland College Cup for the person making the greatest contribution to bowls - Elish Reilly and Kendall Hodson.
Touch: Wicken Cup for the girl having the best season - Michaela Matenga; Kirker Trophy for the player having the best season - Kahu Goad.
Sailing: Atkinson Cup for outstanding all-round contribution to sailing - Steph Vining.
Cricket: Holmes Cup for the boy having the best season for the school - Josh Sansom. Equestrian: Jack Collin Cup for best allround season - Danielle Guiver.
Volleyball: Nayland College Cup for the most promising junior girl - Anna Fockenga; Nayland College Cup for the most promising junior boy - Laughlan Campion; Hegarty Cup most valuable player at national competition - Alex McCreary and Saskia Wanklyn; Fraser Galloway Trophy for most valuable player - Scott Cameron.
Skiing: Crouch Trophy for the person making the greatest contribution to skiing - Mixed Ski Team.
Badminton: Nayland College Trophy for the player having the best season - Zaimon Sansom.
Hockey: Mathieson Cup for the girl making outstanding contribution - Ella Orr and Linda Spring; Nayland College Cup for the boy having the best season - Ryan Clements.
Rugby: Girls Rugby Award - Natasha Kara; Nelson Bays Trophy for the most improved junior player - Tane Raumati; Cowman Cup for the player making the best season - Kelly Duff.
Football: Founders Award for the most improved girl - Ruby Cunningham; Cullen Cup for Best And Fairest (MVP) - Alex McCreary; Bonny Trophy for the most promising male footballer - Josh Sansom; First XI Boys Cup for the Most Valuable Player - Sam Maxwell and Willow Milliagan.
Netball: Nayland College Cup for the most promising junior player - Maggie Riley; Dianne Gregg Cup for the most improved player junior or senior - Brianna Joyes; Hodgson Cup for the player making greatest contribution - Hayley McPherson; Nayland College Cup for the player having the best season (MVP) -Michaela Matenga.
Basketball: Farquhar Cup for junior girl having the best season - Holly Chandler; Alastair Gardner Cup for junior boys basketball - Jack Lovell; Thompson Trophy for the girls having the best season - Sara Reidie; Nayland College Trophy for the having the best season - Angus Riley & Scott Cameron.
- The Nelson Mail
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Proposed closure of Salisbury School puts students at risk, lawyers say
Whorehouse stars leaves audience satisfied
Pines power through to Volleyball New Zealand club championships final


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Volume #2 of Ed Piskor's Hip Hop Family Tree is here!
Remember comic books' future king Ed Piskor's Hip Hop Family Tree last year? We were pretty excited to learn that the deeply detailed history of hip hop was going to be published in comic book form by Fantagraphics, and news that the second volume is about to drop has us going as much as the first did. Volume #2 covers years 1981 to 1983, when RUN-DMC, NWA and the Beastie Boys are arriving on the scene, in the same faultlessly retro detail as #1 did.
Ed actually uploads new pages to Boing Boing as he draws them too, which is just the best treat going. "They say the story of Jesus is the greatest ever told," MTV say in praise for the book, "but JC didn't steal a DJ mixer during the New York Blackout of '77 or bomb a subway car with Fab Five Freddy." Which is a claim we believe to be true. You can pre-order it here now.
- Submit Saturdays: First impressions and Cover Pages
- A futuristic framework for the retrospective of pioneering "total design" advocate Ove Arup
- Cool off with this week's Best of the Web and who to follow on social media
- Elena Éper's spirited illustrations to make you smile and squirm
- Pencil Bandit and Grey London produce quirky branded stings for E4
- Tommy Cash subverts the tropes of rap videos with a fleshy celebration of the human body (NSFW)
- Pentagram unveils refresh of Mastercard's brand mark and identity
- Chris (Simpsons Artist)'s surreal but accurate illustrations of creative jobs
- Benedict Redgrove's beautifully hypnotic film about how a tennis ball is created
- Ian Davis' picturesque paintings of bureaucratic dystopia
- Photographer Adrienne Salinger's series of teenage bedrooms from the 90s
- Is it ever OK to work for free?


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A Comprehensive Nutrient Management Computer Model for Livestock Producers
Abstract:This paper describes the features of a newly developed computer model for livestock waste nutrient management. The paper covers the flexible user features including the ability to define an enterprise (number & type of animal, confinement type, manure handling system, etc.), a manure treatment and application method (pit, lagoon, spray irrigate, soil injection, etc.), and the type and acreage of all crops to which the animal residuals will be applied. The paper also describes the several databases that form the basis for the model's calculations. Examples are presented to demonstrate how the model can be used to not only develop required nutrient management plans, but also to optimize the producer's use of land and capital, while meeting environmental requirements.
Document Type: Research Article
DOI: http://dx.doi.org/10.2175/193864700784994696
Publication date: January 1, 2000
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Yahoo Originals - Yahoo Finance
Why investors should be thrilled about Facebook's Newsfeed change
The panic among publishers is palpable. Facebook (FB) is tweaking its Newsfeed algorithm again – elevating posts from friends and family at the expense of all else and it is working. This is not the first time Facebook has made changes to its algorithm. What's important is Facebook noticed a…Yahoo Finance16 mins ago
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For the first time this year the Fed acknowledged subsiding economic risks, a 180-degree pivot from the March statement when it warned of risks abroad. When the Fed finally voted to raise rates in December — for the first time in over a decade — the statement described risks as "balanced." Many…Justine Underhill38 mins ago
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You are seeing more ads on Facebook than ever before
As Facebook's global user base soared to 1.71 billion in the second quarter, its ad revenue soared too, up 63% in Q2 to $6.24 billion. The growth of Facebook's total ad impressions (the number of times an ad is seen) was 49% last quarter, about even with the 50% growth of the prior quarter. When…Daniel Roberts
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Security camera systems allow you to keep your family and property protected from criminal activity. See why many homeowners are making the switch.
Pokemon has invaded earnings season
On Tuesday, Apple (AAPL) was asked about the impact of the addictive augmented-reality (AR) game after the company reported better-than-expected revenues. CEO Tim Cook said the popularity speaks to the power of AR. "It's incredible what has happened there," Cook said on the company's conference…Nicole Sinclair
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Only utilities (XLU) are in the green, while industrials (XLI) are leading the way down. Alan Valdes, director of floor operations at Silverbear, joins us live from the New York Stock Exchange. To discuss the other big stories of the day, Alexis Christoforous is joined by Yahoo Finance's Rick…Yahoo Finance
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Yahoo Finance is tracking the stocks you're following, based on your Yahoo Finance ticker searches.Seana Smith
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Boeing says 30K new pilots needed every year to keep up with travel growth
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Facebook reports another mega quarter, crushing revenue
Facebook just had another outstanding quarter, surprising no one. Facebook has only missed earnings one time since it went public in 2012. "Our community and business had another good quarter," said Facebook CEO Mark Zuckerberg.Daniel Roberts
Malcolm Gladwell: Black Lives Matter is about the 'restoration of the American ideal'
The Mothers of the Movement, a group of black mothers who lost their children to gun violence, endorsed Hillary Clinton at the Democratic National Convention on Tuesday. As seven mothers walked across the stage to discuss their children's deaths, several at the hands of police, chants of "black…Melody Hahm
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Robert Shiller identifies the surprising source of the world's problems today
Global stocks have stabilized since Britain's decision to leave the European Union rocked major indices worldwide. As economic uncertainty lingers, it may be hard to pinpoint the root of the world's problems today. "People are worried about technology," said Shiller.Seana Smith
Stocks waver as Fed signals rate hike coming
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This is the most positive Fed statement we've seen in a while
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text: Home Storage and high costs will hamper physically-backed base metals ETF, says market High fees and logistical issues such as storage will increase the costs of investing in a physically-backed base metals exchange-traded fund (ETF) and hamper financial institutions' efforts to launch one, according to market participants Traders and analysts are expecting banks to ride on the coat tails of the successful physically-backed ETFs in precious metals amid mounting speculation that they will try to launch similar products using industrial metals, such as copper. The market is also particularly exercised by the prospect of a physically-backed aluminium ETF planned by Credit Suisse and Glencore. "There are loads of banks talking about it. It's the natural evolution that you'll have a copper ETF," an executive at a category IV London Metal Exchange member told MB. Others agreed that banks are considering following in Credit Suisse/Glencore's footsteps. "I think we'll see [banks] try to roll out across all metals," a London analyst said. The first sign of a financial institution launching a physically-backed ETF came on Thursday when GAM Holding, a unit of Swiss and Global Asset Management (S&G), was reported to be planning to list physically-backed base metals... To view this content, please take a free trial or subscribe to our service in just a few steps. Already registered? Log in Discover what Metal Bulletin has to offer with a FREE 7 day trial: Access to latest news and interviews View a sample of all 950+ prices No commitment Try our global metal company database Get free access now Subscribe now to get full access to Metal Bulletin, including: 950+ metals prices and premiums Pricing analysis tool Live news and breaking news email alerts Contact information for 11,500+ companies Subscribe now …or Contact Us +44 (0) 20 7779 8260 email@example.com Related news {{article|snippet:'title'|removeHtmlTags}} {{article|fields:'dates'|date:dateArticleFormat}}


text:
Native Plants
Q. Who is Mr. Smarty Plants?
A: There are those who suspect Wildflower Center volunteers are the culpable and capable culprits. Yet, others think staff members play some, albeit small, role. You can torture us with your plant questions, but we will never reveal the Green Guru's secret identity.
Did you know you can access the Native Plant Information Network with your web-enabled smartphone?
Ask Mr. Smarty Plants is a free service provided by the staff and volunteers at the Lady Bird Johnson Wildflower Center.
rate this answer
Saturday - September 26, 2009
From: Waxhaw, NC
Region: Southeast
Topic: Shrubs
Title: Small evergreen shrubs for horse barn in North Carolina
Answered by: Nan Hampton
QUESTION:I want to plant some low growing evergreen shrubs in pots in my paddock around my barn. The horses can occasionally be in this are but not for an extended time. I am in NC. Any suggestions?
ANSWER:The following are small evergreen shrubs that are found in North Carolina. None of them occurs on any of the toxic plant databases that I searched (Poisonous Plants of North Carolina, Cornell University Plants Poisonous to Livestock, Toxic Plants of Texas, University of Pennsylvania Poisonous Plants, and Canadian Poisonous Plants Information System), so the plants should be safe FOR the horses. However, I don't know if they will be safe FROM the horses, i.e., I don't know whether the horses might think they are very tasty.
You should realize that plants in pots do not withstand cold weather as well as plants whose roots are in the ground. If you have a prolonged very cold period, you should consider protecting the potted plants to keep their roots from freezing. You can read about Overwintering Potted Plants from the Brooklyn Botanic Garden.
Artemisia ludoviciana (white sagebrush)
Ilex glabra (inkberry) has cultivars that are only 3-4 feet high, e.g., Ilex glabra 'Shamrock'
Juniperus communis var. depressa (common juniper) and here are photos and more information.
Leiophyllum buxifolium (sandmyrtle)
Morella cerifera (wax myrtle) has dwarf cultivars
Paxistima canbyi (Canby's mountain-lover)
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October 10, 2013 - Could you please recommend a method for scarifying Pavonia seeds? Thank you
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February 23, 2009 - I would like to know some native blooming shrubs, and roses for my area. I have found that all of the old native plants have a greater success rate. I would like to find a white shrub rose for plant...
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Small area native plant gardening for an apartment
November 14, 2008 - Mr.Smarty, We live in an apartment and are fortunate to have a small area, 5'x5', and so want color! Here in Houston the winters don't freeze much and the summers are HOT. Luckily, we are in the ...
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Deer Resistant Roses and Fruit Trees in NC
April 20, 2015 - Hello, I am planning a house on Lake Gaston in North Carolina (to be built) and will need to establish a new garden on the cleared lot. I would like to focus on native plants, but I love a cutting ga...
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Privacy Hedge for Maryland Porch
July 03, 2014 - I am working on a screen/fence, which is a barrier hedge between our house and our next door neighbor's house to add privacy to our screen porch and dining area, especially in winter. The fence would...
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text:
Papulonecrotic Tuberculids Workup
- Author: Manuel Valdebran, MD; Chief Editor: William D James, MD more...
Laboratory Studies
Patients should be evaluated for evidence of active tuberculosis or other forms of mycobacterial infection. Tuberculous involvement of the female genital tract may account for the increased incidence in females, and a culture of menstrual fluid and endometrial biopsy may be of value in excluding occult disease.
CBC count, chemistry panel, and urinalysis should be performed.
The erythrocyte sedimentation rate is often very high and can be used to monitor treatment. It decreases 4-6 weeks after treatment is started.
Imaging Studies
Chest radiography is needed to rule out active or past pulmonary tuberculosis. Abdominal radiographs may show lymph node calcifications typical of tuberculosis.
Other Tests
Purified protein derivative (PPD) intradermal skin tests are usually strongly positive. Some authors require this result for diagnosis. However, false-negative negative results can occur in the setting of immunosuppression.
QuantiFERON®-TB Gold test can also be used to confirm latent tuberculosis infection, avoiding the risk of severe skin reactions that may occur with PPD testing.[12]
Histologic Findings
The histologic features vary with the timing of the biopsy. In an early lesion, evidence of a vasculitis, which is typically leukocytoclastic with fibrinoid necrosis of the vessel wall and karyorrhectic debris, should be present. However, some authors have found that the primary lesion consists of lymphohistiocytic, rather than leukocytoclastic, vasculitis. It has been reported as a constant finding in a series of cases the presence of a psoriasiform epidermal hyperplasia.[2]
Characteristic of the disorder is the presence of perivascular spongy edema. Later, because of the obliterative vascular changes, a wedge-shaped area of focal dermal necrosis develops, surrounded by a granulomatous inflammatory infiltrate with giant cells and epithelioid histiocytes. Well-formed tuberculoid granulomas with Langerhans giant cells are not usually present in the lesions. Special stains for mycobacteria are typically negative.
The histologic differential diagnosis depends on the timing of the biopsy as well as the histologic appearance. In particular, inflammatory palisading granulomas (ie, granuloma annulare and infectious granulomas) may look similar as compared to those found occasionally in papulonecrotic tuberculid. However, the ability to exclude mucin and infectious organisms in effect rules out granuloma annulare and infectious granulomas, respectively.[13]
Darier MJ. Des "tuberculides" cutanees. Ann Dermatol Syph. 1896. 7:1431-36.
Tirumalae R, Yeliur IK, Antony M, George G, Kenneth J. Papulonecrotic tuberculid-clinicopathologic and molecular features of 12 Indian patients. Dermatol Pract Concept. 2014 Apr. 4(2):17-22. [Medline]. [Full Text].
Sloan JB, Medenica M. Papulonecrotic tuberculid in a 9-year-old American girl: case report and review of the literature. Pediatr Dermatol. 1990 Sep. 7(3):191-5. [Medline].
Iden DL, Rogers RS 3rd, Schroeter AL. Papulonecrotic tuberculid secondary to Mycobacterium bovis. Arch Dermatol. 1978 Apr. 114(4):564-6. [Medline].
Freiman A, Ting P, Miller M, Greenaway C. Papulonecrotic tuberculid: a rare form of cutaneous tuberculosis. Cutis. 2005 Jun. 75(6):341-6. [Medline].
Morrison JG, Fourie ED. The papulonecrotic tuberculide. From Arthus reaction to lupus vulgaris. Br J Dermatol. 1974 Sep. 91(3):263-70. [Medline].
Senol M, Ozcan A, Aydin A, Karincaoglu Y, Sasmaz S, Sener S. Disseminated lupus vulgaris and papulonecrotic tuberculid: case report. Pediatr Dermatol. 2000 Mar-Apr. 17(2):133-5. [Medline].
Milligan A, Chen K, Graham-Brown RA. Two tuberculides in one patient--a case report of papulonecrotic tuberculide and erythema induratum occurring together. Clin Exp Dermatol. 1990 Jan. 15(1):21-3. [Medline].
Thappa DM, Karthikeyan K, Jayanthi S. Tuberculid in a child: transformation from papulonecrotic to lichen scrofulosorum. Pediatr Dermatol. 2003 Jan-Feb. 20(1):91-3. [Medline].
Asiniwasis R, Dutil MT, Walsh S. Molluscum-Like Papules as a Presentation of Early Papulonecrotic Tuberculid in Association with Nodular Tuberculid in a Male with Asymptomatic Active Pulmonary Tuberculosis. J Cutan Med Surg. 2014 Aug 1. 18(0):1-4. [Medline].
Chalermdamrichai P, Puavilai S, Jerasutus S, Boonsarngsuk V, Kiattboonsri S, Suwatanapongched T. Sarcoidosis presenting as papulonecrotic tuberculid-like lesions: report of a case. J Med Assoc Thai. 2004 Jul. 87(7):839-44. [Medline].
Sim JH, Whang KU. Application of the QuantiFERON®-TB Gold test in erythema induratum. J Dermatolog Treat. 2014 Jun. 25(3):260-3. [Medline].
Puri N. A clinical and histopathological profile of patients with cutaneous tuberculosis. Indian J Dermatol. 2011 Sep-Oct. 56(5):550-2. [Medline]. [Full Text].
[Guideline] World Health Organization. Recommendations for Investigating Contacts of Persons with Infectious Tuberculosis in Low- and Middle-Income Countries. Available at http://apps.who.int/iris/bitstream/10665/77741/1/9789241504492_eng.pdf. Accessed: October 23, 2014.


text: 40cm Knitted Lambswool London Soldiers Cushion by Sally Nencini £55$98.46€66.34$73.82 This item is currently unavailable £6.95$12.44€8.38$9.32 delivery to United States Receive this item 5-10 working days from dispatch International delivery available we're sorry we're sorry, This item is currently unavailable it will be available on 31-07-2016 quantity buy a gift voucher related categories baby & child > soft furnishings & accessories > children's cushions home > bedroom > decorative accessories > cushions > patterned cushions baby & child > london-themed by Sally Nencini Location: Norfolk, GB read seller's profile see seller's complete range more items from this seller Knitted Lambswool London Skyline Cushion by Sally Nencini £50$89.51€60.31$67.11 Knitted Lambswool Picture Cushions by Sally Nencini £55$98.46€66.34$73.82 Knitted Lambswool Dolly by Sally Nencini £38$68.03€45.83$51 Knitted Lambswool Baby Monkey by Sally Nencini £16$28.64€19.30$21.47 Knitted Lambswool Mini Bunny's by Sally Nencini £20$35.80€24.12$26.84 Knitted Lambswool Scallop Bobble Hat by Sally Nencini £30$53.70€36.18$40.26 view all you may also like PRODUCT DETAILS CUSTOMER REVIEWS DELIVERY RETURNS Made in Britain eco-friendly save for later A 40cm cushion knitted in 100% softest lambswool. This cushion features lots of marching London soldiers in smart red and black uniforms on a pearl grey background. All knitted in soft lambswool, lightly felted. Great for kids rooms and London loving adults alike! The back is striped black and grey and there is a black zip fastening. Included is a feather cushion pad. Available in 40cm square. made from: 100% Lambswool cover, hand wash only. Handmade in the UK. dimensions: 40cm square. product code: 148567 1 customer review read about our product rating system ratings guide trusted independent customer feedbackforum excellent bad good poor This product is dispatched to you by Sally Nencini. MAINLAND UK order now and receive this item by price Free Delivery Monday 1 August FREEFREEFREEFREE NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch FREEFREEFREEFREE Northern Ireland 2-5 working daysfrom dispatch FREEFREEFREEFREE Other UK Islands 2-5 working daysfrom dispatch FREEFREEFREEFREE INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £5.00$8.95€6.03$6.71 Rest of Europe 5-10 working daysfrom dispatch £5.00$8.95€6.03$6.71 USA & Canada 5-10 working daysfrom dispatch £6.95$12.44€8.38$9.32 Asia & Australasia 5-10 working daysfrom dispatch £7.25$12.97€8.74$9.73 Rest of the world 5-14 working daysfrom dispatch £7.25$12.97€8.74$9.73 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Sally Nencini's return policy Please see notonthehighstreet.com's returns policy.


text:
Sins of the Motherby Saundra Crum
Sins of the Mothers is a fictional narrative inspired by true events. What we do in life matters to
- LendMe LendMe™ Learn More
Rita Carter surprises her therapist by insisting that she is her own Great-Great Grandmother. This forces the therapist to treat not just Rita, but her ancestors as well, as she tries to get to the bottom of Rita's problems in the present time.
Sins of the Mothers is a fictional narrative inspired by true events. What we do in life matters to those who come after us even though we may think it is our business and we should be able to act any way we want. Our choices affect not only us, but will affect our children and those around us, as well as those who are born long after our time on this earth. We all make both good and bad choices just as the characters in this work of historical fiction do.
Product Details
- 2940015912395
- Publisher:
- A Mysterious Ohio
- Publication date:
- 10/30/2012
- Sold by:
- Barnes & Noble
- Format:
- NOOK Book
- Pages:
- 374
- File size:
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Lamborghini Murciélago LP670-4 SuperVeloce
Amazing SV from Saudi Arabia in Cannes. Seger and I where standing near the sea in Cannes, when we heard something very loud coming our way.. We ran over to the street and saw this beast coming! Damn, what a car! Stickers and rims wouldn't be my choice though..
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text:
|Publication number
|Publication type
|Publication date
|Feb 17, 1959
|Filing date
|Jul 18, 1956
|Priority date
|Jul 18, 1956
|Publication number
|Turner Leonard E
|Original Assignee
|Turner Leonard E
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (6), Referenced by (27), Classifications (10)
|External Links: USPTO, USPTO Assignment, Espacenet
vFeb. 17, 1959 L. E. TURNER PIPE HANDLING TOOL Filed July 18. 1956 Fig. 4
INVENTOR Leonard E. Turner ATTORNEYS United States Patent "ice PIPE HANDLING TooL Leonard E. Turner, Stanton, Tex. Application July 18, 1956, Serial No. 598,701 7 Claims. Cl. 294-15 This invention relates to new and useful improvements in pipe handling tools.
One object of the invention is to provide an improved pipe handling tool having a hand support and a pivoted closure member carried by the hand support whereby the tool may be held suspended in one hand with its closure member over a pipe and free to swing, and the tool moved downwardly to swing the closure member automatically into a locking position.
Another object of the invention is to provide an improved tool of the character described which has a closure member adapted to be latched in pipe holding position and adapted when unlatchcd to automatically swing downward and free the pipe, when the tool is moved upwardly.
A further object of the invention is to provide an improved pipe handling tool which comprises comparatively few parts and lends itself to free and automatic operation.
Still another'object of the invention is to provide an improved pipe handling tool so arranged that it may be grasped by a fixed handle with a closure member medially and pivotally suspended over a pipe and free, when unlatched, to be automatically swung to a closed or open movement upon a downward or upward movement of the tool.
' A construction designed to carry out the invention will be hereinafter described, together with other features of the invention.
The invention will be more readily understood from a reading of the following specification and by reference to the accompanying drawing, wherein an example of the invention is shown, and wherein:
Fig. l is a perspective view of a pipe handling tool in its closed position and constructed in accordance with the invention,
Fig. 2 is a viewin elevation of the tool gripping a pipe, shown in transverse section, a portion of the head of the tool being broken away to show the latch mechanism,
Fig. 3 is a view similar to Fig. 2, with the closure member unlatched and the tool elevated above the pipe, and
Fig. 4 is an end elevational view of the latch end of the tool in its closed position.
In the drawings, the numeral designates a hand member and 11 designates an arcuate closure member pivoted intermediate its ends to one end of the hand member whereby, when the closure member is released and the hand member is supported or held in the hand of the operator, the closure member swings down to an open position as is shown in Fig. 3. Upon moving the tool downwardly over and transversely of a pipe, so as to straddle the same, a finger 12 formed on the closure member and underlying the hand member is engaged by the pipe and causes the closure member. to swing around the pipe and coact with the hand member in gripping said pipe. Upon release, the closure member is swung from the pipe when the hand member is lifted. The arrangement and relation of the elements, one to another, is important.
2,873,995 Patented Feb. 17,1959
The entire tool is made of a suitable metal or other material and the band member 10 includes an arcuate handle-pr grip; 13, properly rounded transversely, intermediate its ends, to provide a comfortable hand grip. At the left hand end (in the drawings) the handle is merged into a head 14. from which a curved clamping jaw 15 depends. At the opposite or right hand end (in the drawings), the handle .is curved abruptly downwardly into a hanger 16, which is bifurcated to provide a medial slot 17 with depending lugs 18 on each side (Fig. l).
The arcuate closure member 11 at its medial portion and on its upper and outer side, has an integral boss 19 which is provided with an upstanding central tongue 20, movably engaging in the slot between the lugs 18 and centrally pivoted on a transverse hinge bolt 21 fastened in said lugs. The 'boss 19 has an arcuate recess 22 on each side of the base of the tongue to accommodate the rounded bottoms -23 of the lugs and provide freedom of swinging movement. Likewise the top vof the slot 17 is curved to accommodate the arcuate top of the boss 19. The hanger 16 has on its inner side a projecting stop 24 overhanging the finger 12. 'The finger is formed at its free end with a keeper 25 which is adapted to register with the outer end;of an elongated transverse slot 26 in a boss 27 extending from the head 14. A transverse spring-p'ressed-latch bar 28 'is disposed to slide longitudinally. in the'slot and has its outer end 29 bevelled downwardly'and' inwardly so as to be depressed when thef ree end of the finger 12 is swung upward thereacross. As the end of the finger rides over the bevelled end of the latch bar, a coiled spring 30, which has been comin Fig.4.
pressed, expels the end of the end bar under the keeper 25, whereby the closure member 11' is fastened in its closed position. i A screw bolt 31, slidable in an opening 32 extending through the head 14 is screwed into the inner end of'the latch bar 28 and the spring 30 is coiled around the bolt and confinedin the slot 26.. The head 33 of the bolt '31'is loosely engaged in a recess 34 in the outer end of a centrally pivoted lever 35. The 'lever' is pivoted at 36 in .a slot 37 inthe outer face of thelhead 14 and has an angularly disposed arm 38 projecting from the upper end of the slot. By depressing the arm, the lever is swung and the latch bar 28 is withdrawn from the keeper 25. V
The closure member 11 has its lower portion formed into a curved swinging jaw 15' which is substantially a duplicate'of the-jaw 15. The structure, and relation to each other, of "the jaws and the finger 12 is highly important. It is to be noted thatthe jaw members and the finger have "approgrirnately cylindrical faces 39, which, when the toolisj closed, form a substantially continuous arcuate wall in surrounding relation to the pipe surface. The pivoting 'andfa s'tened positions of the closure mem ber 11 are such that when the latch bar 28 is withdrawn, the member 11 will swingdown to the posit-ion shown In -using' the 't'ooly'the operator graspsthe handle 13 with the parts in the positions shown in Fig. 4 and lowers the tool over the pipe A. As the tool is lowered, the finger 12 is brought into engagement with the pipe, whereby the jaw 15' is swung inwardly toward the pipe. Continued lowering of the tool causes the finger 12 to swing upwardly until it engages the latch bar 28 and is thus secured in gripping position. When in such position, the lower ends of the jaws will be below the transverse center of the pipe and close enough to the pipe to grip the same below its transverse center when the tool is lifted.
It is pointed out that the tool being suspended by the handle 13 and the'finger 12 being latched, any movement of the tool, either up or down, will have no etfect upon the pipe gripping action of its elements and nor is the fatigue as great as if the hand gripping action was applied at the finger 12. When it is desired to release the pipe, it is merely necessary to depress the arm '39 which withdraws the latch bar 28 and frees the finger 12, and then, simply by the users lifting the tool upwardly, the closure member 11 swings downwardly and frees the tool from the pipe. It is to be noted that the upper surface of the latch'bar 28 which engages the keeper 25 is inclined downwardly and the keeper is similarly inclined. Thus, the weigh of a pipe or other article supported between the jaws 15 and 15 is applied to the latch bar and keeper in such a manner as not to impede the ready withdrawal of the latch bar from beneath the keeper when the pipe is to be released.
When the tool is held suspended in the operators hand, the closure member is pendant and free to swing on its pivot bolt 21 to move the jaws 15 and 15' apart to receive a pipe. In use it is merely necessary to position the jaws 15 and 15 over the pipe and move the tool downwardly, the closing together of the jaws and the latching of the closure member in pipe-supporting position becoming automatic after the finger 12 contacts the pipe and the downward movement is continued.
This tool is particularly adapted to placing and lifting thin-walled irrigating pipe from one furrow to another furrow, but has other uses also.
The foregoing description of the invention is explanatory thereof and variouschanges in the size, shape and materials, as well as in the details of the illustrated construction may be made, within the scope of the appended claims, without departing from the spirit of the invention.
What I claim and desire to secure by Letters Patent 1. A handling tool including, a handle member having a handle intermediate its ends, a hinge at one end of the handle member, a latch at the opposite end of the handle member, a relatively fixed jaw depending from the handle member, and a closure member pivotally connected intermediate its ends at the hinge and including a jaw disposed to coact with the fixed jaw in gripping an article and also including a finger having afree end and disposed in the path of an article to be gripped between the jaws and adapted to engage the latch at its free end.
2. A handling tool including, a handle member, a depending clamping jaw fixed to the handle member, an arcuate closure member -medially and pivotally connected to one end of the handle member havinga swinging jaw depending at one side of its pivot to coact with the clamping jaw and a finger extending from the opposite side of its pivot disposed to be engaged by an article tobegripped between the jaws to automatically move the swinging jaw toward the clamping jaw, and a latch carried by the handle member in position to be engaged by the finger when the closure member is swung to a closed position.
' arcuate closure member medially and pivotally connected to one end of the handle member having a swinging jaw depending at one side Of" its pivot to coact with the clamping jaw and a finger extending from the opposite side of its pivot disposed to be engaged by an article to be gripped between the jaws to automatically close the swinging jaw, and latch means carried by the handle member for engaging the closure member, the closure member when unlatched being free to swing downwardly and away from the clamping jaw and to straddle an article to be engaged.
4. A handling tool as set forth in claim 1 wherein the jaws and the finger have coacting approximately cylindrical faces for engaging around a cylindrical article.
5. A handling tool including, a head member having a handle intermediate its ends, a clamp depending from one end of the head member in fixed relation thereto, a curved closure member hingedly connected intermediate its ends to one end of the head member and having a finger member and a clamp member, the finger member having a latch element on its outer end, and a latch carried by the head disposed to engage the latch element of the finger member of the closure member.
6. A handling tool including, a head member having a handle intermediate its ends, a clamp depending from one end of the head member in fixed relation thereto, a curved closure member hinged intermediate its ends to the opposite end of the head member and having a finger member underlying the handle and a clamp member depending in spaced relation to the clamp, the finger member having a latch element on its outer end, a latch carried by the head disposed to engage the latch element of the finger member of the closure member, and a stop carried by the head member in the path of the closure member to limit the upward swing of the finger member.
7. A handling tool including, a head member having a handle intermediate its ends, a clamping jaw depending from one end of the head member in fixed relation thereto, a curved closure member hingedly connected intermediate its ends to the opposite end of the head member and having a finger member and a clamp member, the finger member having a latch element on its outer end, a latch carried by the head disposed to engage the latch element of the finger member of the closure member, and a latch operating arm extending from the head member at the latch, the latch extending at a downward angle with respect to the handle.
References Cited in the file of this patent UNITED STATES PATENTS 338,349 Johnstone Mar. 23, 1886 763,338 Baker June 21, 1904 1,111,338 Watson Sept. 22, 1914 2,342,506 Wrobbel Feb. 22, 1944 2,665,162 Moore Ian. 5, 19 54 FOREIGN PATENTS 27,613 Great Britain Dec. 9, 1912
|Cited Patent
|Filing date
|Publication date
|Mar 23, 1886
|Feb 23, 1904
|Jun 21, 1904
|James M Baker
|Hose-carrying tongs.
|Apr 30, 1913
|Sep 22, 1914
|John W Watson
|Jul 30, 1942
|Feb 22, 1944
|American Car & Foundry Co
|May 1, 1951
|Jan 5, 1954
|Meyers Edward J
|Watermelon carrier
|Title not available
|Citing Patent
|Filing date
|Publication date
|Sep 25, 1959
|Aug 29, 1961
|Werner Co Inc R D
|Clamping device for scaffolding
|May 12, 1961
|May 12, 1964
|Retha Frost
|Aircraft tow bar
|Apr 6, 1962
|Mar 23, 1965
|Robert E Bendl
|Helicopter cargo hook and release system
|May 13, 1963
|Jul 13, 1965
|Up Right Inc
|Locking hook
|Jun 30, 1964
|May 17, 1966
|Frank Reznicek
|Releasable hay bale handling hook
|Nov 22, 1963
|Jun 28, 1966
|E Z Bag Inc
|Automatic bottom-loading bowling bag
|Jun 23, 1971
|Oct 23, 1973
|Chicago Rawhide Mfg Co
|Apparatus for removing parts from molding cavities
|Dec 15, 1972
|Apr 16, 1974
|Us Navy
|Underwater torpedo recovery device
|Apr 9, 1991
|Jul 28, 1992
|Photon Kinetics, Inc.
|Clamp for an elongate member
|Apr 19, 1994
|Apr 30, 1996
|Bush; John B.
|Ladder handle assembly
|Jul 18, 1994
|Jun 11, 1996
|Thompson; Andy L.
|Irrigation pipe tools
|Jun 10, 1996
|Aug 11, 1998
|Thompson; Andy L.
|Irrigation pipe tools
|Aug 11, 2000
|May 21, 2002
|Cosco Management, Inc.
|Foldable step stool with leg lock and handle
|Apr 17, 2001
|Sep 24, 2002
|Cosco Management, Inc.
|Foldable step stool with leg lock and handle
|Aug 27, 2003
|Sep 12, 2006
|Cosco Management, Inc.
|Foldable step ladder with leg aligner and handle
|Nov 7, 2005
|Oct 2, 2007
|Gilberto Urdiales
|Tool for lifting elongated objects—pivotable grapple
|Nov 7, 2005
|Feb 12, 2008
|Gilberto Urdiales
|Tool for lifting elongated objects—rotatable grapple
|Jun 1, 2006
|May 13, 2008
|Cosco Management, Inc.
|Foldable step ladder with leg aligner and handle
|Jun 2, 2009
|Nov 15, 2011
|Longyear Tm, Inc.
|Spring-loaded rod handling device
|Apr 6, 2012
|Oct 7, 2014
|Handsaver Handles, LLC
|Ladder carrying apparatus and method of modifying a ladder
|Apr 30, 2014
|Feb 2, 2016
|Dale Gregg
|Hose handle systems
|Aug 27, 2003
|Mar 3, 2005
|Meeker Paul K.
|Foldable step ladder with leg aligner and handle
|Jul 26, 2004
|May 19, 2005
|Cortez Rick D.
|Pipe-handling tool
|Dec 1, 2006
|Jul 19, 2007
|Dean Gilliss
|Pipe engaging and lifting apparatus
|Feb 5, 1965
|Dec 28, 1967
|Gutehoffnungshuette Sterkrade
|Transporthandgriff fuer ein Rohr
|Jan 24, 2003
|Aug 7, 2003
|Cortez Rick D
|Pipe-handling tool
|Jan 24, 2003
|Apr 1, 2004
|Rick D Cortez
|Pipe-handling tool
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification


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