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Pediatric Bruton Agammaglobulinemia Clinical Presentation
- Author: Terry W Chin, MD, PhD; Chief Editor: Harumi Jyonouchi, MD more...
All patients with Bruton agammaglobulinemia, now formally termed X-linked agammaglobulinemia (XLA), are males. More than 90% of affected males present with unusually severe or recurrent sinopulmonary infections. Meningitis, osteomyelitis, sepsis, and GI tract infectious (eg, gastroenteritis or diarrhea) are less common initial manifestations of XLA.[21]
The images below depict patients diagnosed with Bruton agammaglobulinemia.
Infants typically develop recurrent otitis media, pneumonia, and sinusitis before age 1 year but after 3 months. By mid childhood, chronic sinusitis becomes prevalent, and the prevalence of otitis media decreases.
Infectious agents involved are usually S pneumonia or H influenzae type b. Both are extracellular encapsulated bacteria. As patients become older, encapsulated bacteria continue to be the most common sources of infection, although staphylococcal infections must also be considered. Neisseria meningitidis and Moraxella catarrhalis, which is not encapsulated, are other bacteria whose portal of entry is the respiratory tract.
A chronic cough in a patient may indicate a risk for chronic pulmonary disease, which may be restrictive, obstructive, or both.
Infections due to Mycoplasma and Ureaplasma species have been reported in both adolescents and adults. In addition, organisms usually thought of as indicating T-cell immunodeficiency may be present, such as Pneumocystis jirovecii.[22]
The child may also have diarrhea that is not completely explained by frequent antibiotic use. Many patients have diarrhea caused by Giardia or Campylobacter species, and management of the diarrhea is difficult, even with appropriate therapy.[23]
Four types of gastrointestinal diseases can be described: infectious, malignancy, inflammatory, and autoimmune.[24]
Although patients with agammaglobulinemia are usually able to handle viral infections, they are susceptible to certain viruses that replicate in the GI tract and then spread to the CNS. This indicates the importance of antibody production in limiting the spread of infections with enteroviruses such as poliovirus, echovirus, and coxsackievirus.
Chronic bacteremia and skin infections caused by Helicobacter and related species (eg, Flexispira,Campylobacter) in patients with XLA are now appreciated.[25] Campylobacter infection can also be associated with a reactive arthritis in patients with XLA.[26]
Patients may present with vaccine-related poliomyelitis after immunization with the live poliovirus vaccine.[27] Although prolonged secretions of a virus have been described (up to 637 days postvaccination), based on 3 separate studies, poliovirus carrier status among people with primary immune deficiency appears to be rare and may not manifest with disease. Conversely, enteroviral infections are potentially fatal, irrespective of route of acquisition (ie, community acquired or acquired via the live poliovirus vaccine).
Katamura et al (2002) described nonprogressive viral myelitis in a patient with XLA and suggested that the prognosis of CNS infections in agammaglobulinemia is not based on the Ig level alone and that they are not always progressive or fatal.[28]
The use of intraventricular infusion of Ig has been well documented in XLA patients with CNS viral infection. However, the infusions have not been documented to prevent death caused by chronic enteroviral infection of the CNS.
Invasive fungal and other opportunistic infections remain rare, even in older patients with XLA and debilitating chronic lung or GI disease.
Autoimmune disorders may be associated with infections at the patient's initial presentation or may develop in older patients. Inflammatory bowel disease is particularly common. Other autoimmune disorders include cytopenias. Arthritis indistinguishable from juvenile rheumatoid arthritis (JRA) may be the presenting manifestation in patients with XLA.[29] Overall, 7-22% of patients with agammaglobulinemia develop joint manifestations. Reactive arthritis with Campylobacter coli infections is common. Enthesitis-related arthritis has also been described in a boy with XLA.[30] Other autoimmune disorder such as Kawasaki disease has been described in XLA.[31]
Evaluating for chronic infectious processes is essential. Mycoplasmal infection is a common cause of severe chronic erosive arthritis. Patients with mild cases rapidly respond to antimicrobial therapy, such as tetracycline. In more severe cases, arthritis may improve following treatment with IVIG. The need to always consider infectious etiology is further indicated by a case of XLA with JRA who developed invasive Klebsiella septic arthritis.[32]
Interestingly, malignancies are rare and are not currently a significant cause of mortality. The risk for XLA appears to be much less than the other immunodeficiency syndromes. Multiple neoplasms in the GI tract have been reported.[33]
A family history of other affected males should be sought because approximately one third of affected patients have an affected family member.[18] However, female carriers have no clinical manifestations related to their mutated allele.
Infants and older patients with XLA typically appear healthy. In healthy infants, lymphoid tissues such as tonsils and peripheral lymph nodes are poorly developed; therefore, the absence of these tissues is not noted until patients are toddlers. A poor local inflammatory response also compromises the usefulness of physical examination findings. For example, patients may have hypoplastic tonsils and lymph nodes that fail to undergo normal hypertrophy in response to infection. Therefore, physicians should suspect XLA in male infants who have unusually severe pneumonias associated with bacteremia or who have unusually frequent otitis media, chronic cough, or congestion. The last 2 symptoms typically respond to antibiotic therapy in a timely fashion but may soon recur.
In a study by Sikora and Lee (2003), up to 48% of patients developed sinusitis. Upon examination, patients may have hypoplastic tonsils and lymph nodes that fail to undergo normal hypertrophy in response to infection.[34]
Staphylococcal conjunctivitis and skin infections are less common than sinopulmonary infections, but they may also be part of the initial presentation in patients with XLA. These staphylococcal infections are less useful for discriminating XLA from other illnesses because they are frequently present in immunocompetent individuals and in individuals with other primary immunodeficiencies such as hyperimmunoglobulin E (hyper-IgE) syndrome and other antibody deficiencies.
Diarrhea caused by Giardia species is part of the classic presentation in any patient with antibody deficiency disease. Patients with XLA have an increased risk for other infectious etiologies of diarrhea, including Campylobacter jejuni, Shigella species, and Salmonella species. Infections due to these organisms seem to respond less well to medical therapy and also seem to become chronic more often in patients with antibody deficiency diseases than in others.
Rarely, patients with XLA also have a short stature caused by a deficiency in growth hormone.[35] A newly discovered mutation in myeloid elf-1–like factor may be responsible for the disease.[36] These patients must be distinguished from patients with XLA who have poor growth secondary to malnutrition.
As discussed in Pathophysiology, the disease is caused by impaired function of Btk. More than 600 mutations have been identified, ranging from single base pari substitutions to small insertions or deletions to gross deletions.[37] If a mutation in BTK cannot be found, the absence of BTK RNA or protein is considered the criterion standard for validating a diagnosis of XLA. Mutations of BTK account for 85-90% of patients with early-onset agammaglobulinemia and an absence of B cells.
Mutations in BTK are found in all areas of the gene. The pleckstrin homology region, the tyrosine kinase region, and areas referred to as Src homology domains (SH1, SH2, and SH3) are all important for gene function. Defects in these exons are most common. Splice defects that involve introns account for fewer than 20% of the abnormalities. Rare mutations in the promoter upstream region have been described. In some milder cases of XLA, the Btk protein is still present, although in a mutated form and in lesser amounts . However, no genotype-phenotype correlation has been found. Some studies suggest a genotype-phenotype correlation, specifically between genotype and age of disease onset as well as occurrence of severe infections[38] but other studies fail to find a correlation.[39, 40]
Bruton OC. Agammaglobulinemia. Pediatrics. 1952 Jun. 9(6):722-8. [Medline].
Khan WN. Colonel Bruton's kinase defined the molecular basis of X-linked agammaglobulinemia, the first primary immunodeficiency. J Immunol. 2012 Apr 1. 188(7):2933-5. [Medline].
York NR, de la Morena MT. 50 years ago in the journal of pediatrics: a decade with agammaglobulinemia. J Pediatr. 2012 May. 160:756.
Mohamed AJ, Yu L, Backesjo CM, et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009 Mar. 228(1):58-73. [Medline].
Sochorova K, Horvath R, Rozhova D et al. Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. Blood. 2007. 109:2553-6. [Medline].
Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21. 282(51):36953-60. [Medline].
Taneichi H, Kanegane H, Sira MM, et al. Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia. Clin Immunol. 2008 Feb. 126(2):148-54. [Medline].
Hasan M, Lopez-Herrera G, Blomberg KE. Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. Immunology. 2008. 123:239-49. [Medline].
Schmidt NW, Thieu VT, Mann BA et al. Bruton's tyrosine kinase in required for TLR-induced IL-10 production. J Immunol. 2006. 117:7203-10. [Medline].
Nasseri S, Sorouri R, Pourpak Z, Yeganeh M, Aghamohammadi A, Fiorini M, et al. Molecular characterization of Bruton's tyrosine kinase deficiency in 12 Iranian patients with presumed X-linked agammaglobulinemia. J Investig Allergol Clin Immunol. 2011. 21:572-4. [Medline].
Vijayan V, Baumgart-Vogt E, Naidu S, Qian G, Immenschuh S. Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages. J Immunol. 2011 Jul 15. 187(2):817-27. [Medline].
Abbott JK1, Ochs HD, Gelfand EW. Coding-region alterations in BTK do not universally cause X-linked agammaglobulinemia. J Allergy Clin Immunol. Nov 2013. 132:1246-8.
Toth B, Volokha A, Mihas A, et al. Genetic and demographic features of X-linked agammaglobulinemia in Eastern and Central Europe: a cohort study. Mol Immunol. 2009 Jun. 46(10):2140-6. [Medline].
Lopez-Herrera G, Berron-Ruiz L, Mogica-Martinez D, Espinosa-Rosales F, Santos-Argumedo L. Characterization of Bruton's tyrosine kinase mutations in Mexican patients with X-linked agammaglobulinemia. Mol Immunol. 2008 Feb. 45(4):1094-8. [Medline].
Ramalho VD, Oliveira Júnior EB, Tani SM, Roxo Júnior P, Vilela MM. Mutations of Bruton's tyrosine kinase gene in Brazilian patients with X-linked agammaglobulinemia. Braz J Med Biol Res. 2010 Sep. 43(9):910-3. [Medline].
Qin X1, Jiang LP, Tang XM, Wang M, Liu EM, Zhao XD. Clinical features and mutation analysis of X-linked agammaglobulinemia in 20 Chinese patients. World J Pediatr. Aug 2013. 9:273-7. [Medline].
Merchant RH, Parekh D, Ahmad N, Madkaikar M, Ahmed J. X linked agammaglobulinemia: a single centre experience from India. Indian J Pediatr. Jan 2014. 81:92-94.
Chun JK, Lee TJ, Song JW, Linton JA, Kim DS. Analysis of clinical presentations of Bruton disease: a review of 20 years of accumulated data from pediatric patients at Severance Hospital. Yonsei Med J. 2008 Feb 29. 49(1):28-36. [Medline].
De Silva R, Gunawardena S, Wickremesinghe G, Ranasinghe B, Namasivayam Y. Primary immune deficiency among patients with recurrent infections. Ceylon Med J. 2007 Sep. 52(3):83-6. [Medline].
Aghamohammadi A, Fiorini M, Moin M, et al. Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia. Int Arch Allergy Immunol. 2006. 141(4):408-14. [Medline].
Mohiuddin MS, Abbott JK, Hubbard N, Torgerson TR, Ochs HD, Gelfand EW. Diagnosis and evaluation of primary panhypogammaglobulinemia: a molecular and genetic challenge. J Allergy Clin Immunol. Jun 2013. 131:1717-8. [Medline].
Jongco AM, Gough JD, Sarnataro K, Rosenthal DW, Moreau J, Ponda P, et al. X-linked agammaglobulinemia presenting as polymicrobial pneumonia, including Pneumocystis jirovecii. Ann Allergy Asthma Immunol. Jan 2014. 112:74-75. [Medline].
Ariganello P1, Angelino G, Scarselli A, Salfa I, Della Corte M, De Matteis A, et al. Relapsing Campylobacter jejuni Systemic Infections in a Child with X-Linked Agammaglobulinemia. Case Rep Pediatr. 2013. 2013:735108.
Agarwal S, Mayer L. Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes. J Allergy Clin Immunol. 2009 Oct. 124(4):658-64. [Medline].
Freeman AF, Holland SM. Persistent bacterial infections and primary immune disorders. Curr Opin Microbiol. 2007. 10:70-5. [Medline].
Arai A, Kitano A, Sawabe E, et al. Miura ORelapsing Campylobacter coli bacteremia with reactive arthritis in a patient with X-linked agammaglobulinemia. Intern Med. 2007. 46:605-9. [Medline].
Mamishi S, Shahmahmoudi S, Tabatabaie H, et al. Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis. Eur J Pediatr. 2008 Mar 4. [Medline].
Katamura K, Hattori H, Kunishima T, et al. Non-progressive viral myelitis in X-linked agammaglobulinemia. Brain Dev. 2002 Mar. 24(2):109-11. [Medline].
Bloom KA, Chung D, Cunningham-Rundles C. Osteoarticular infectious complications in patients with primary immunodeficiencies. Curr Opin Rheumatol. 2008 Jul. 20(4):480-5. [Medline]. [Full Text].
Sukumaran S, Marzan K, Shaham B, Church JA. A child with x-linked agammaglobulinemia and enthesitis-related arthritis. Int J Rheumatol. 2011. 2011:175973. [Medline]. [Full Text].
Behniafard N1, Aghamohammadi A, Abolhassani H, Pourjabbar S, Sabouni F, Rezaei N. Autoimmunity in X-linked agammaglobulinemia: Kawasaki disease and review of the literature. Expert Rev Clin Immunol. Feb 2012. 8:155-9. [Medline].
Zhu Z1, Kang Y, Lin Z, Huang Y, Lv H, Li Y. X-linked agammaglobulinemia combined with juvenile idiopathic arthritis and invasive Klebsiella pneumoniae polyarticular septic arthritis. Clin Rheumatol. Feb 2014. Epub. [Medline].
Brosens LA, Tytgat KM, Morsink FH, et al. Multiple colorectal neoplasms in X-linked agammaglobulinemia. Clin Gastroenterol Hepatol. 2008 Jan. 6(1):115-9. [Medline].
Sikora AG, Lee KC. Otolaryngologic manifestations of immunodeficiency. Otolaryngol Clin North Am. 2003 Aug. 36(4):647-72. [Medline].
Stewart DM, Tian L, Notarangelo LD, Nelson DL. X-linked hypogammaglobulinemia and isolated growth hormone deficiency: an update. Immunol Res. 2007. 38(1-3):391-9. [Medline].
Stewart DM, Tian L, Notarangelo LD, Nelson DL. Update on X-linked hypogammaglobulinemia with isolated growth hormone deficiency. Curr Opin Allergy Clin Immunol. 2005 Dec. 5(6):510-2. [Medline].
Shin DM, Jo EK, Kanegane H, et al. Transcriptional regulatory defects in the first intron of Bruton's tyrosine kinase. Pediatr Int. 2008 Dec. 50(6):801-5. [Medline].
Lee PP, Chen TX, Jiang LP, et al. Clinical characteristics and genotype-phenotype correlation in 62 patients with X-linked agammaglobulinemia. J Clin Immunol. 2010 Jan. 30(1):121-31. [Medline].
Wang Y, Kanegane H, Wang X, et al. Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China. J Clin Immunol. 2009 May. 29(3):352-6. [Medline].
Teimourian S, Nasseri S, Pouladi N, Yeganeh M, Aghamohammadi A. Genotype-phenotype correlation in Bruton's tyrosine kinase deficiency. J Pediatr Hematol Oncol. 2008 Sep. 30(9):679-83. [Medline].
Bondioni MP, Duse M, Plebani A, et al. Pulmonary and sinusal changes in 45 patients with primary immunodeficiencies: computed tomography evaluation. J Comput Assist Tomogr. 2007 Jul-Aug. 31(4):620-8. [Medline].
Gharagozlou M, Ebrahimi FA, Farhoudi A, et al. Pulmonary complications in primary hypogammaglobulinemia: a survey by high resolution CT scan. Monaldi Arch Chest Dis. 2006 Jun. 65(2):69-74. [Medline].
Moreau T, Calmels B, Barlogis V, et al. Potential application of gene therapy to X-linked agammaglobulinemia. Curr Gene Ther. 2007 Aug. 7(4):284-94. [Medline].
Liu Y, Wu Y, Lam KT, Lee PP, Tu W, Lau YL. Dendritic and T cell response to influenza is normal in the patients with X-linked agammaglobulinemia. J Clin Immunol. 2012 Jun. 32(3):421-9. [Medline]. [Full Text].
Ballow M. Safety of IGIV therapy and infusion-related adverse events. Immunol Res. 2007. 38(1-3):122-32. [Medline].
Chinen J, Shearer WT. Subcutaneous immunoglobulins: alternative for the hypogammaglobulinemic patient?. J Allergy Clin Immunol. 2004 Oct. 114(4):934-5. [Medline].
Ochs HD, Gupta S, Kiessling P, Nicolay U, Berger M. Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases. J Clin Immunol. 2006 May. 26(3):265-73. [Medline].
Gustafson R, Gardulf A, Hansen S, et al. Rapid subcutaneous immunoglobulin administration every second week results in high and stable serum immunoglobulin G levels in patients with primary antibody deficiencies. Clin Exp Immunol. 2008 May. 152(2):274-9. [Medline].
Leal RC, Bertelli EC, Soler ZA. Recurrent pneumonia caused by genetic immunodeficiency: a prophylactic and rehabililtative approach. Braz J Infect Dis. 2007. 11:307-10. [Medline].
Orange JS, Hossny EM, Weiler CR, et al. Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. J Allergy Clin Immunol. 2006 Apr. 117(4 Suppl):S525-53. [Medline].
Orange JS, Grossman WJ, Navickis RJ, Wilkes MM. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. Clin Immunol. 2010 Oct. 137(1):21-30. [Medline].
Moore ML, Quinn JM. Subcutaneous immunoglobulin replacement therapy for primary antibody deficiency: advancements into the 21st century. Ann Allergy Asthma Immunol. 2008 Aug. 101(2):114-21; quiz 122-3, 178. [Medline].
Berger M. Incidence of infection is inversely related to steady-state (trough) serum IgG level in studies of subcutaneous IgG in PIDD. J Clin Immunol. 2011 Oct. 31(5):924-6. [Medline].
Beaute J, Levy P, Millet V, et al. Economic evaluation of immunoglobulin replacement in patients with primary antibody deficiencies. Clin Exp Immunol. May/2010. 160:240-5. [Medline]. [Full Text].
Howard V, Myers LA, Williams DA, et al. Stem cell transplants for patients with X-linked agammaglobulinemia. Clin Immunol. 2003 May. 107(2):98-102. [Medline].
Quinti I, Pierdominici M, Marziali M, Giovannetti A, Donnanno S, Chapel H. European surveillance of immunoglobulin safety--results of initial survey of 1243 patients with primary immunodeficiencies in 16 countries. Clin Immunol. 2002 Sep. 104(3):231-6. [Medline].
Buckley RH. Pulmonary complications of primary immunodeficiencies. Paediatr Respir Rev. 2004. 5 Suppl A:S225-33. [Medline].
Chen Y, Stirling RG, Paul E, Hore-Lacy F, Thompson BR, Douglass JA. Longitudinal decline in lung function in patients with primary immunoglobulin deficiencies. J Allergy Clin Immunol. 2011 Jun. 127(6):1414-7. [Medline].
Quinti I, Soresina A, Guerra A, et al. Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study. J Clin Immunol. 2011 Jun. 31(3):315-22. [Medline].
Basile N, Danielian S, Oleastro M, et al. Clinical and molecular analysis of 49 patients with X-linked agammaglobulinemia from a single center in Argentina. J Clin Immunol. 2009 Jan. 29(1):123-9. [Medline].
Quartier P, Debre M, De Blic J, et al. Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients. J Pediatr. 1999 May. 134(5):589-96. [Medline].
Aghamohammadi A, Allahverdi A, Abolhassani H, et al. Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia. Respirology. 2010 Feb. 15(2):289-95. [Medline].
Aghamohammadi A, Cheraghi T, Rezaei N, et al. Neutropenia associated with X-linked Agammaglobulinemia in an Iranian referral center. Iran J Allergy Asthma Immunol. 2009 Mar. 8(1):43-7. [Medline].
Jacobs ZD, Guajardo JR, Anderson KM. XLA-associated neutropenia treatment: a case report and review of the literature. J Pediatr Hematol Oncol. 2008 Aug. 30(8):631-4. [Medline].
Cunningham-Rundles C. Autoimmunity in primary immune deficiency: taking lessons from our patients. Clin Exp Immunol. 2011 Jun. 164 Suppl 2:6-11. [Medline]. [Full Text].
Ziegner UH, Kobayashi RH, Cunningham-Rundles C, et al. Progressive neurodegeneration in patients with primary immunodeficiency disease on IVIG treatment. Clin Immunol. 2002 Jan. 102(1):19-24. [Medline].
Papapetropoulos S, Friedman J, Blackstone C, Kleiner GI, Bowen BC, Singer C. A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency receiving chronic IVIG therapy. Mov Disord. 2007 Aug 15. 22(11):1664-6. [Medline].
Berlucchi M, Soresina A, Redaelli De Zinis LO, et al. Sensorineural hearing loss in primary antibody deficiency disorders. J Pediatr. 2008 Aug. 153(2):293-6. [Medline].
Staines Boone AT, Torres Martínez MG, López Herrera G, de Leija Portilla JO, Espinosa Padilla SE, Espinosa Rosales FJ, et al. Gastric Adenocarcinoma in the Context of X-linked Agammaglobulinemia : Case Report and Review of the Literature. J Clin Immunol. 34. Feb 2014:134-7. [Medline].
Lopez-Granados E, Perez de Diego R, Ferreira Cerdan A, et al. A genotype-phenotype correlation study in a group of 54 patients with X-linked agammaglobulinemia. J Allergy Clin Immunol. 2005 Sep. 116(3):690-7. [Medline].
Gonzalo-Garijo MA, Sánchez-Vega S, Pérez-Calderón R, Pérez-Rangel I, Corrales-Vargas S, Fernández de Mera JJ, et al. Renal Amyloidosis in a Patient with X-linked Agammaglobulinemia (Bruton's Disease) and Bronchiectasis. J Clin Immunol. Jan 2014. 34:119-22. [Medline].
Morwood K, Bourne H, Gold M, et al. Phenotypic variability: clinical presentation between the 6th year and the 60th year in a family with X-linked agammaglobulinemia. J Allergy Clin Immunol. 2004 Apr. 113(4):783-5. [Medline].
Soresina A, Nacinovich R, Bomba M, et al. The quality of life of children and adolescents with X-linked agammaglobulinemia. J Clin Immunol. 2009 Jul. 29(4):501-7. [Medline].
Sigmon JR, Kasasbeh E, Krishnaswamy G. X-linked agammaglobulinemia diagnosed late in life: case report and review of the literature. Clin Mol Allergy. 2008 Jun 2. 6:5. [Medline]. [Full Text].
Aghamohammadi A, Moin M, Farhoudi A, et al. Efficacy of intravenous immunoglobulin on the prevention of pneumonia in patients with agammaglobulinemia. FEMS Immunol Med Microbiol. 2004 Mar 8. 40(2):113-8. [Medline].
Black C, Zavod MB, Gosselin BJ. Haemophilus influenzae lymphadenopathy in a patient with agammaglobulinemia: clinical-histologic-microbiologic correlation and review of the literature. Arch Pathol Lab Med. 2005 Jan. 129(1):100-3. [Medline].
Conley ME, Broides A, Hernandez-Trujillo V, et al. Genetic analysis of patients with defects in early B-cell development. Immunol Rev. 2005 Feb. 203:216-34. [Medline].
Conley ME, Howard V. Clinical findings leading to the diagnosis of X-linked agammaglobulinemia. J Pediatrics. 2002. 141:566-71. [Medline].
Eijkhout HW, van Der Meer JW, Kallenberg CG, et al. The effect of two different dosages of intravenous immunoglobulin on the incidence of recurrent infections in patients with primary hypogammaglobulinemia. A randomized, double-blind, multicenter crossover trial. Ann Intern Med. 2001 Aug 7. 135(3):165-74. [Medline].
Merchant RH, Parekh D, Ahmad N, Madkaikar M, Ahmed J. X linked agammaglobulinemia: a single centre experience from India. Indian J Pediatr. Jan 2014. 81:92-94.
Morales P, Hernandez D, Vicente R, et al. Lung transplantation in patients with x-linked agammaglobulinemia. Transplant Proc. 2003 Aug. 35(5):1942-3. [Medline].
Ní Gabhann J, Spence S, Wynne C, Smith S, Byrne JC, Coffey B, et al. Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-? production by natural killer cells. Clin Immunol. 2012 Mar. 142(3):373-82. [Medline].
Plebani A, Soresina A, Rondelli R, et al. Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: an Italian multicenter study. Clin Immunol. 2002 Sep. 104(3):221-30. [Medline].
Skull S, Kemp A. Treatment of hypogammaglobulinaemia with intravenous immunoglobulin, 1973-93. Arch Dis Child. 1996 Jun. 74(6):527-30. [Medline].
Staines Boone AT1, Torres Martínez MG, López Herrera G, de Leija Portilla JO, Espinosa Padilla SE, Espinosa Rosales FJ, et al. Gastric Adenocarcinoma in the Context of X-linked Agammaglobulinemia : Case Report and Review of the Literature. J Clin Immunol. Feb 2014. 34:134-7. [Medline].
Yu PW, Tabuchi RS, Kato RM, et al. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood. 2004. 104:1281-90. [Medline]. [Full Text].
|Manufacturing Process
|Additives (IVIG products containing sucrose are more often associated with renal dysfunction, acute renal failure, and osmotic nephrosis, particularly with preexisting risk factors [eg, history of renal insufficiency, diabetes mellitus, age >65 y, dehydration, sepsis, paraproteinemia, nephrotoxic drugs].)
|Parenteral Form and Final Concentrations
|IgA Content mcg/mL
|Carimune NF
(ZLB Behring)
|Kistler-Nitschmann fractionation, pH 4 incubation, nanofiltration
|6% solution: 10% sucrose, < 20 mg NaCl/g protein
|Lyophilized powder 3, 6, 9, 12%
(Grifols USA)
|Cohn-Oncley fractionation, PEG precipitation, ion-exchange chromatography, pasteurization
|Sucrose free, contains 5% D-sorbitol
|Liquid 5%
|< 50
|Gammagard Liquid 10%
(Baxter Bioscience)
|Cohn-Oncley cold ethanol fractionation, cation and anion exchange chromatography, solvent detergent treated, nanofiltration, low pH incubation
|0.25 M glycine
|Ready-for-use liquid 10%
|Gammar-P IV
(ZLB Behring)
|Cohn-Oncley fraction II/III, ultrafiltration, pasteurization
|5% solution: 5% sucrose, 3% albumin, 0.5% NaCl
|Lyophilized powder 5%
|< 20
(Talecris Biotherapeutics)
|Cohn-Oncley fractionation, caprylate-chromatography purification, cloth and depth filtration, low pH incubation
|Contains no sugar, contains glycine
|Liquid 10%
(Bio Products)
|Solvent/detergent treatment targeted to enveloped viruses; virus filtration using Pall Ultipor to remove small viruses including nonenveloped viruses; low pH incubation
|Contains sorbitol (40 mg/mL); do not administer if fructose intolerant
|Ready-for-use solution 5%
|< 10
|Iveegam EN
(Baxter Bioscience)
|Cohn-Oncley fraction II/III, ultrafiltration, pasteurization
|5% solution: 5% glucose, 0.3% NaCl
|Lyophilized powder 5%
|< 10
|Polygam S/D
Gammagard S/D
(Baxter Bioscience for the American Red Cross)
|Cohn-Oncley cold ethanol fractionation followed by ultracentrafiltration and ion exchange chromatography, solvent detergent treated
|5% solution: 0.3% albumin, 2.25% glycine, 2% glucose
|Lyophilized powder 5%, 10%
|< 1.6 (5% solution)
(Octapharma USA)
9/24/10: Withdrawn from market because of unexplained reports of thromboembolic events
|Cohn-Oncley fraction II/III, ultrafiltration, low pH incubation, S/D treatment pasteurization
|10% maltose
|Liquid 5%
(Swiss Red Cross for the American Red Cross)
|Kistler-Nitschmann fractionation, pH 4 incubation, trace pepsin, nanofiltration
|Per gram of IgG: 1.67 g sucrose,< 20 mg NaCl
|Lyophilized powder 3, 6, 9, 12%
(CSL Behring)
|pH 4 incubation, octanoic acid fractionation, depth filtration, and virus filtration
|10% solution; Preservative-free and sucrose- and maltose-free
|Ready-to-use solution 10%
|Manufacturing Process
|Parenteral Form and Final Concentrations
|IgA Content mcg/mL
(ZLB Behring)
|Cold ethanol fractionation, pasteurization
|2.25% glycine, 0.3% NaCl
|Liquid 16% (160 mg/mL)
|< 50 mcg/mL


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Springer Seminars in Immunopathology
, Volume 21, Issue 3, pp 317-338
First online:
Th1/Th2 balance in infection
- Carmen Infante-DuarteAffiliated withDeutsches Rheumaforschungszentrum Berlin
- , Thomas KamradtAffiliated withDeutsches Rheumaforschungszentrum BerlinMedizinische Klinik m.S. Rheumatologie/Klinische Immunologie, Universitatsklinikum Charité
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Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of Cyokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections. In some infectious diseases, most notably leishmaniasis or infections with gastrointestinal helminths, one Th subset is indispensable for clearing the infection, whereas the opposite Th subset is detrimental. More frequently, both Th1 and Th2 responses are required at different time points to effectively eradicate an infectious agent. The granuloma responses to eitherMycobacterium tuberculosis orSchistosoma mansoni provide illustrative examples and are discussed in this review. There is accumulating evidence for frequent coexpression of Th1 and Th2 Cyokines during the in vivo immune response to infections. The mechanisms by which infectious agents modulate Th1/Th2 phenotype development are summarized here. Finally, we review here the current evidence for cytokine imbalances induced by infections as pathogenic or protective factors in autoimmunity and allergy.
Reference tools
- Title
- Th1/Th2 balance in infection
- Journal
Springer Seminars in Immunopathology
Volume 21, Issue 3 , pp 317-338
- Cover Date
- 1999-12
- Print ISSN
- 0344-4325
- Online ISSN
- 1432-2196
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Industry Sectors
- Authors
- Carmen Infante-Duarte (1)
- Thomas Kamradt (1) (2)
- Author Affiliations
- 1. Deutsches Rheumaforschungszentrum Berlin, Monbijoustrasse 2, D-10117, Berlin, Germany
- 2. Medizinische Klinik m.S. Rheumatologie/Klinische Immunologie, Universitatsklinikum Charité, D-10098, Berlin, Germany

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text:
Boshers rejoins 'pen; Ramirez designated for assignment
Lefty reliever Buddy Boshers rejoined the Twins before their series opener against the Red Sox on Thursday and right-handed reliever Neil Ramirez was designated for assignment.
Via Twins.com
4 days ago
Twins outright RP Neil Ramirez
Mike Berardino of the Twin Cities Pioneer Press reports that the Minnesota Twins have outrighted relief pitcher Neil Ramirez after his incredibly short and incredibly difficult tenure with the team. Minnesota had picked up Ramirez off of waivers from the Milwaukee Brewers last month, and in 14.2 relief innings for the Twins, Ramirez gave up five home […] The post Twins outright...
Via Today's Knuckleball
5 days ago
Braun returns to Brewers lineup
MILWAUKEE -- Brewers outfielder Ryan Braun is back in the lineup against the St. Louis Cardinals after missing two games with neck stiffness.Braun hasn't played since Saturday in Cincinnati, when he pinch-hit and hit into a double play."Taking your listed No. 3 hitter out of the lineup, I think we've done really well," manager Craig Counsell said. "It's never easy losing one of your...
Via Associated Press
May 31, 2016 | Discuss
Cubs activate reliever Ramirez from bereavement list
CHICAGO (AP) The Chicago Cubs have activated reliever Neil Ramirez from the bereavement list and optioned right-hander Spencer Patton to Triple-A Iowa. The Cubs announced the moves before Sunday's game against the Washington Nationals. The right-handed Ramirez began the day with a 4.50 ERA in six appearances. Patton made one appearance for the Cubs.
Via Associated Press
May 08, 2016 | Discuss
Reinventing the Neil: Ramirez Looking to Overcome Velocity and Shoulder Issues
The Cubs have a Neil Ramirez problem. After crushing the competition in 2014, to the tune of 43 2/3 innings pitched, a 1.44 ERA, 2.61 FIP, and 10.9 K/9 with 3.5 BB/9, Ramirez fell off in 2015 due to problems with his throwing shoulder. His average fastball velocity, which was 95.4 MPH in 2014, dropped […]
Via BP Wrigleyville
March 24, 2016 | Discuss
Cubs Player Profile: Neil Ramirez
Position: RP, Disabled List 2015 Stats: 14 IP, 3.21 ERA, 4.09 DRA, 25 K%, 10 BB% Have you heard the phrase "under-promise and over-deliver?" It comes to mind what I think of Neil Ramirez and his career so far with the Cubs. He came over as the PTBNL in the Matt Garza trade, which usually […]
Via BP Wrigleyville
December 14, 2015 | Discuss
Ramirez's continued health issues aren't helping struggling bullpen
Is Neil Ramirez headed back to the disabled list?Chicago Cubs manager Joe Maddon hopes not, but he couldn't say it's not off the table, according to CSNChicago, after the right-handed reliever has had an apparent setback after missing two months of the season with right shoulder inflammation.Ramirez looked like a gem last season as a rookie, but since his return from the shoulder...
Via Fox Sports
July 29, 2015 | Discuss
Neil Ramirez placed on DL
Neil Ramirez was placed on the 15 day DL with sore triceps yesterday and I only have a few words (a few more than I've had in awhile). People need to relax on Neil Ramirez. I just spoke with him and he said it is simply to give his arm a rest. Very important part of Cubs. — David Kaplan (@thekapman) July 26, 2014 There you have it. Very important part of Cubs to rest players...
Via Obstructed View
July 30, 2014 | Discuss
DFP: Neil Ramirez and Rusney Castillo
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Via Obstructed View
July 28, 2014 | Discuss
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Via World Series Dreaming
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Pinot Days: Tasting Ticket
Skirball Cultural Center • Los Angeles, CA
Saturday, December 7
What you get
- Choice of Two Tickets
- Sample More than 100 Wines from Around the World!
Prized for its light and subtle flavors, Pinot Noir is a wine loved all around the world. With this offer, save your spot at Pinot Days, an annual celebration of this tasty variety. Held on Saturday, December 7 at the Skirball Cultural Center, this event showcases wine from more than 60 vineyards from around the world.
Choose from the following offers:
• $49 ($75 value) for one Grand Festival Public Tasting ticket (3 to 6 p.m.)
• $79 ($120 value) for one VIP Diversity Seminar and Grand Festival Public Tasting ticket (1 to 6 p.m.), including access to the festival at 1 p.m. and an hour-long sit-down tasting
Pinot Days's Website
Fine printREFUND POLICY: This event is nonrefundable. No full or partial refunds are given to customers who miss the event. In the event of a cancellation, your voucher will be fully refunded • Each voucher is good for 1 person • Must be 21+ to drink alcohol • The deal is valid only for tickets on the date of the event as listed and may not be exchanged or redeemed for any other dates • Purchaser may change the name of the individual retrieving tickets up to 24 hours in advance of event via the LivingSocial website event details section; no name-changes or alternate pick-ups permitted without notice at venue • Entire value must be used in a single visit
Other conditions apply
Except where noted in the fine print:
• Cannot be combined with any other offer or promotion
• Tax and gratuity are not included
• Merchant is responsible for the quality of the products or services provided to you at redemption
• LivingSocial Terms and Conditions - https://m.livingsocial.com/terms
Pinot Days: Tasting Ticket
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text:
1-16 of 36 results for Books : Languages : By Language : German : By Publisher : Under £5 : Hardcover
Germane Ideas for German Teachers (Ideas - a Collins Educational photocopy master)14 Oct 1993by Stanley Goodman and Jean Lucas
The Oxford-Duden German Dictionary: German-English/English-German1 Jun 1999by J.B. Sykes and W. Scholze-Stubenrecht
German Grammar and Usage1 Oct 1977by A.E. Hammer
Other Formats:Paperback, Hardcover
Poetry Book: 1st16 Aug 1979by John Foster
Other Formats:Paperback
Government and Politics in Western Europe: Britain, France, Italy, Germany (Comparative European Politics)1 Jul 1993by Yves Meny and Andrew Knapp
The Oxford Study German Dictionary (Bilingual Dictionary)31 Jul 1999by Valerie Grundy and etc.
Collins German Phrase Book : (Collins Phrase Books :)1973by Gerda Williamson
Other Formats:Hardcover


text:
Lauryn Hill asks judge for leniency in upcoming tax evasion sentencing claiming she failed to file taxes due to threats and withdrawal from society
Threats to herself and her family prompted former Fugees singer Lauryn Hill to skip paying taxes for three years.
Hill recently filed court documents seeking leniency in her upcoming sentencing for tax evasion claiming she skipped out on her taxes due to the perceived threats and because of her overall withdrawal from society.
The 37-year-old former singer for the Fugees previously pleaded guilty for failing to file tax returns from 2005 to 2007, a period when she earned $1.8m.
Tax Evader: Former Fugees singer Lauryn Hill has filed legal documents seeking leniency in her upcoming sentencing for tax evasion, claiming her actions were part of her overall withdrawal from society.
The Killing Me Softly singer stopped paying taxes 'when she withdrew from society at large due to what she perceived as manipulation and very real threats to herself and her family,' according to court documents obtained by TMZ.
The hip-hop artist didn't elaborate on the perceived threats.
Hill also has asked the court to consider other factors before her sentencing, including her contention that she can pay off her debt faster if she's not imprisoned.
Mug shot: The U.S. Marshals Service took Hill's mug shot last year when she pleaded guilty to tax evasion
Hill was charged in June 2012 for failing to file returns with the Internal Revenue Service and pleaded guilty.
She faces a maximum one-year sentence on each of three counts of tax evasion, plus fines.
In a lengthy post on her Tumblr page last June, Hill claimed she left mainstream society during the 2000s in protest over its 'climate of hostility, false entitlement, manipulation, racial prejudice, sexism and ageism.'
Hill said she also 'embraced my right to resist a system intentionally opposing my right to whole and integral survival.'
Hill rose to fame as the lead singer of the Fugees.
Back together: Hill joined Wyclef Jean and Pras for a Fugees concert in London in 2005
She launched her solo career in 1998 with the critically acclaimed album The Miseducation of Lauryn Hill.
Hill largely disappeared from public view starting about 2000 and has been raising her six children. Five of her children are with Rohan Marley, the son of reggae legend Bob Marley.
A judge was expected act on Hill's request for leniency on April 22.
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text: Best Lingerie Pictures Ever (This Week) By GuySpeed Editors December 22, 2015 4:00 PM | GuySpeed Share on Facebook Share on Twitter T I S t h e S E A S O N ❤ . Naughty or Nice?? Tag your friends . #Cheri #AnaCheri #SantaBaby A photo posted by anacheri (@anacheri) on Dec 6, 2015 at 8:29pm PST aaaand the heat is back ☀ A photo posted by bryana holly (@bryanaholly) on Oct 9, 2015 at 5:00pm PDT A photo posted by Celina Eriksen (@celina_eriksen) on Nov 10, 2015 at 8:00am PST Goodnight it's #bedtime @chantelzales___ A photo posted by Chantel Zales (@chantelzales) on Nov 18, 2015 at 12:01am PST have more fun @justshawn7 @neyrotphoto @artofface70 A photo posted by Shelby Chesnes (@shelbychesnes) on Sep 11, 2015 at 6:32pm PDT BTS for Nymphomaniac in Barcelona #bordelle A photo posted by Ash Hollywood (@hollywoodcensored) on Jul 18, 2015 at 2:56pm PDT Happy Monday @daisysgirl_ lace & silk goodness A photo posted by Steph Pacca (@steph_pacca) on Feb 9, 2015 at 2:53am PST I LOVE love Happy Valentine's Day! @giotraining A photo posted by Jaclyn Swedberg (@pmoy2012) on Feb 14, 2015 at 9:14am PST Yes we are an elite crime-fighting team @jasminewaltz @minniegupta A photo posted by Jackie Dawn (@jackiedawnxo) on Jan 31, 2015 at 7:14pm PST This will be me at @thelightvegas on Thurs with my bottle of @50bleu #drinkbleu ✨ A photo posted by JASMINE WALTZ (@jasminewaltz) on Jan 20, 2015 at 4:47pm PST NEXT: 10 GOOD GIRL ACTRESSES GONE BAD ON FILM Source: Best Lingerie Pictures Ever (This Week) Filed Under: best lingerie pictures Category: Babes | Lists | Photos Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of The Rock Station 99X Guns N' Roses Have Tour Dates Lined Up 'Far Into Next Year' Rogues' Gallery: Daredevil's Top Ten Villains Motley Crue Line of Sex Toys to Debut This Fall Victim Turns Power Washer on Thugs [VIDEO] Recommended For You ZergNet Best of the Web ZergNet


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Blanca Blanco - Jekyll and Hyde premiere - Hollywood, California, United States - Tuesday 12th February 2013 (2 Pictures)
Blanca Blanco
Photo credit: Travis Wade
Blanca Blanco
Photo credit: Daniel Tanner
View All: Jekyll and Hyde premiere
Next Blanca Blanco Slideshow: Movies for Grownups Awards - Los Angeles California United Kingdom - Tuesday 12th February 2013
The 1969 session, including the only known recording of 'Sunshine Woman' by the band, will be included on a re-issue of 'The Complete BBC Sessions'...
The 55 year old actor joined Chris Martin and co. on stage in New Jersey to perform 'Earth Angel' and 'Johnny B. Goode'.
Bjork Digital comes to London's Somerset House in September, along with a single live show at the Royal Albert Hall.
Kim Kardashian released an audio excerpt from a phone call between Kanye and Taylor Swift over the lyrics of 'Famous' - but if it was recorded...
There's very much a strength of conviction in remaining what you were, but arguably more so in becoming what you want to be.
The BBC drama starring Aidan Turner returns to BBC One on September 4th.
Guns N' Roses were detained at the Canadian border last week for gun possession but they're adamant the weapon didn't belong to them.


text:
PowerColor Radeon RX 480 RED DEVIL review
Guru3D Rig of the Month - July 2016
Radeon RX 480 vs GeForce GTX 1060 FCAT Frametime Analysis Review
Gigabyte GeForce GTX 1060 G1 GAMING Review
Anidees AI-Crystal Tempered Glass review
MSI GeForce GTX 1060 GAMING X Review
Palit GeForce GTX 1060 Super Jetstream Review
GeForce GTX 1060 Review
GeForce GTX 1060 FCAT Frametime Analysis Review
MSI GeForce GTX 1080 GAMING Z 8G review
Radeon HD 5770 review
Posted by: Hilbert Hagedoorn on: 10/12/2009 02:00 PM [ 0 comment(s) ]
In collaboration with ATI and HIS we will test the Radeon HD 5770 in single and a CrossfireX (Multi-GPU) setup. It's a product that performance wise positions itself directly in-between the Radeon 4850 and 4870, yet comes with all the features that the 5870 for example offers. It's new it's affordable, it has AMD written all over it ... head on over to the next page where we'll meet and greet Juniper aka Radeon HD series 5700. Read article
« Enermax Revolution 85+ 850W review · Radeon HD 5770 review · GeForce GT 220 review »


text:
this is the only hip hop i like, has a old school feel to me, not over done, but with a groove. can i say run DMC .....? I dunno
Much Support!
I have decided not to "Cross Over by the 31st" into the New Year...I'm going to hang on to the door jam for as long as I can. I'll still be listening to your great music. Doesn't matter what year I'm in, the music is just so fine! I'm her to wish you a Happy Old Year! Be safe in your travels. May all your dreams come true if you really go through with crossing in to the New Year. You can write, wire, phone if you like. Cheers! ...=_=... ♥
I wish you a wonderful and happy new year!
2013 will rock!
Wish you love, health, money, passion, and MUSIC ALL YEAR LONG!
Hugs from France!
Wildcath ♥
Rock the World in ②⓪①③
Happy New Year AudioDidacts,great one in 2013.Didorion
Hey there! Thanks for the comment ! Awesome songs here, very good production! It's always nice to have original self taught productions !
Wise is smooth bro. Great job man.
awesome sound... love the vibe on Float Away. Keep on pushing...
"ENJOY ALL THINGS ESPECIALLY THE TOAST" Coffee, Champagne, hot cocoa. May your ENTRANCE be GRAND Your visit GREAT, your exit be FOR-FILLED! ...=_=...


text:
Nukie Timtiman
I am Nukie Timtiman. Former Angelican. Now in the University Of The Philippines Diliman. Artist/Photographer
I use a Canon Rebel T2i or 550D. I started photography about 3 years ago. I love taking photographs that has a story behind it. I love photojournalism. I admire every type of photographs.
I believe art/photographs could change the world.
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Residence Inn New York Manhattan/Central Park, New York
- Free full breakfast and WiFi
Main amenities
- 261 smoke-free guestrooms
- Restaurant and bar/lounge
- Fitness center
- Valet parking
- Business center
- Childcare
- 24-hour front desk
- Coffee/tea in a common area
- Air conditioning
- Daily housekeeping
- Free grocery shopping service
- Front desk safe
What's around
- In Midtown
- Broadway (0.5 mi / 0.8 km)
- Rockefeller Center (0.5 mi / 0.9 km)
- Times Square (0.6 mi / 1 km)
- Ed Sullivan Theater (0 mi / 0.1 km)
- Carnegie Hall (0.2 mi / 0.3 km)
Residence Inn New York Manhattan/Central Park, New York
Hotel Info: 020 3027 9803from £187
- Standard Room, 2 Double Beds (Central Park)
- Studio, 1 King Bed, Park View
- Studio, City View
- Studio, City View
- Studio, View (Times Square)
- Grand Studio, View (Times Square)
Also popular with travellers from the UK
At a glance
Key facts
Hotel size
- This hotel has 261 rooms
- This hotel is arranged over 28 floors
- Check-in time starts at 4 PM
- Check-out time is 11 AM
- Express check-out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Babysitting/childcare *
- Pets allowed *
- Free WiFi in public areas
- Free WiFi and wired Internet access in rooms
- Valet parking *
Other information
- Smoke-free property
Nearby Three Star New York hotels
In the hotel
- Free full breakfast daily
- Restaurant
- Bar/lounge
- Coffee/tea in a common area
- Fitness facilities
- Bicycle rentals nearby
- Golfing nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Sailing nearby
- Business center
- Number of meeting rooms - 7
- Meeting rooms 7
- Conference space size (feet) - 5000
- Conference space size (meters) - 465
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Free grocery shopping service
- Free newspapers in lobby
- Luggage storage
- Multilingual staff
- Elevator/lift
- Safe-deposit box at front desk
In the room
- Air conditioning
- Coffee/tea maker
- Bathrobes
- Iron/ironing board
- Turndown service
- Private bathroom
- Shower/tub combination
- Free toiletries
- Hair dryer
- Satellite TV channels
- Desk
- Free WiFi
- Phone
- Refrigerator
- Microwave
- Kitchenette
- Cookware, dishware, and utensils
- Dishwasher
- Daily housekeeping
- In-room safe
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Special features
Awards and affiliations
Green / Sustainable Property
This property participates in Green Key Eco-Rating Program, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.
Residence Inn New York Manhattan/Central Park, New York's small print
Also known as
- Residence Inn Manhattan Park
- Residence Inn New York Manhattan central Park
- Residence Manhattan Park
- Residence New York Manhattan central Park
- Residence Inn New York Manhattan/Central Park Hotel
- Residence Inn Manhattan/Central Park Hotel
- Residence Inn New York Manhattan/Central Park
- Residence Inn Manhattan/Central Park
Mandatory fees
Pet deposit: USD 250 per stay
Optional extras
Valet parking costs USD 56 per day
Babysitting/childcare is available for an extra charge
Pets are allowed for an extra charge of USD 100 per pet, per stay
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Excellent 4.5 /5 from 808 reviews
Great hotel in excellent position. Complimentary breakfast. Friendly and helpful staff. We had a room on the 63rd floor with breathtaking views.
For an amazing city you need an amazing hotel and this was is,the room was excellent the view from the room out of this world. the breakfast was excellent great choice and quality. the staff were excellent. The location was very convenient for central park and time square.
Wonderful Views, Clean and superb. A+++++
The location of this hotel was brilliant for Broadway and Times Square. The view from our room on the 54th floor was staggering.
We had a fantastic week in a very well situated hotel, convenient to Times Square and Central Park and right on Broadway amongst the theatres. Breakfast was excellent, staff were very polite and informative and we had a beautiful view from our 41st floor room. The bedroom area and storage were a little bit small, however, the kitchenette and bathroom were more than ample. All furniture and fittings were very tasteful. This all helped make our 1st visit to New York a very enjoyable experience.
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- Ebb Tide
- El Presidente
- Excelsior Beach
- Fisherman's Cove
- Fisherman's Haven
- Gulf & Bay Club
- Gulf & Bay Club Bayside
- Gulf Haven
- Gulf Holiday
- Gulf Terrace
- Gumbo Limbo
- Harbor Towers Yacht & Racquet Club
- Harbour Towne Yacht Club
- Harmony
- Horizons West
- House of the Sun
- Hyatt Siesta Key Beach
- Inlets
- Island House
- Island Reef
- Jamaica Royale
- La Siesta
- Mariners Inlet
- Midnight Cove
- Midnight Cove Bayside
- Midnight Cove II
- Midnight Sea
- Moorings
- Navarra On the Key
- Ocean Beach
- Our House at The Beach
- Palm Bay Club
- Peppertree Bay
- Peppertree Gulfside
- Point of Rocks
- Pointe
- Polynesian Gardens
- Private Homes
- Private Homes, Sarasota Beach
- Private Homes, Siesta Isles
- Private Homes, Siesta Key Village
- Private Homes: Palm Island
- Private Homes: Twin Oak Pond
- Provincial Gardens
- Sabal Palms
- Sandbox on the Beach
- Sandpiper Beach Club
- Sandy Cove
- Sarasota By The Sea
- Sarasota Surf & Racquet Club
- Sea Breeze
- Sea Club II
- Sea Crest
- Sea Mist
- Sea Shell
- Sea Spray
- Sea Village
- Sea Winds
- Shells On Siesta Key
- Siesta
- Siesta Beach House
- Siesta Breakers
- Siesta Dunes
- Siesta Harbor
- Siesta Manor
- Siesta Palms by the Beach
- Siesta Sands
- Siesta Shores
- Siesta Towers
- Siestas Bayside Waterside East
- Siestas Bayside Waterside West
- Sun & Sea Island Hideaway
- Sunrise Cove
- Sunset Point
- Sunset Royale
- Tiffany Sands
- Tortuga
- Tropical Breeze
- Turtle Bay
- Twin Banyan
- Twin Palms
- Vista Hermosa
- Whispering Sands
- White Sands Village
- 524 Beach Road
- Aloha Kai
- Anchorage
- At The Beach Apartments
- Banana Bay Club Beachside
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- Beach Place
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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
2 BR 1 BA Sleeps 6$339 avg/night1-3 night min stay
Perfect Location - Siesta Village in the Backyard! - 1.5 Blocks from the Beach! Perfect for Families#8601842 BR 1 BA Sleeps 6$357 avg/night1-3 night min stay
Island House Beach Resort - 9 North#3468540ha2 BR 2 BA Sleeps 6$301 avg/night3-7 night min stay
Drift Away in Paradise - Walk to Beach, Shopping, Dining and Entertainment. Pet Friendly. Great for Groups#8545231 BR 1 BA Sleeps 4$287 avg/night1-3 night min stay
2 BR 3 BA Sleeps 6$189 avg/night7 night min stay
1 BR 1 BA Sleeps 2$283 avg/night1-3 night min stay
1 BR 1 BA Sleeps 4$296 avg/night1-3 night min stay
1 BR 1 BA Sleeps 4$280 avg/night1-3 night min stay
Walk to the Village!#4250379ha2 BR 1 BA Sleeps 4$176 avg/night7-30 night min stay
Sleeps 6 - Siesta Village in the Back Yard! - Short Walk to Beach! Pet Friendly. Perfect for Groups#8601822 BR 1 BA Sleeps 6$358 avg/night1-3 night min stay
2 BR 1 BA Sleeps 5
Open Kitchen Updated Counter Tops with Spectacular Views! La Siesta Condos- Unit on Top Floor!#4233668ha2 BR 2 BA Sleeps 6$140 avg/night7 night min stay
2 BR 1 BA Sleeps 6
3 BR 2 BA Sleeps 8$150 avg/night14-27 night min stay
Island House Beach Resort Villa 18#3472858ha2 BR 2 BA Sleeps 6$201 avg/night3-7 night min stay
2 BR 2 BA Sleeps 8$207 avg/night14 night min stay
1 BR 1 BA Sleeps 4$302 avg/night1-3 night min stay
3 BR 2.5 BA Sleeps 8$205 avg/night14-30 night min stay
Beautifully Decorated Ground Floor Unit- Fully Updated with Walk - in Shower; Fans in All Rooms#4233673ha2 BR 1 BA Sleeps 6$134 avg/night7 night min stay
Walk Out of Your Lanai Just Steps Into La Siesta Heated Pool- Quaint One Bedroom on Ground Floor#4234676ha1 BR 1 BA Sleeps 4$124 avg/night7 night min stay
3 BR 2.5 BA Sleeps 8$213 avg/night7 night min stay
Hasslefree Condo - 2 Minute Walk to the Beach and 3 Minutes to Downtown Siesta - Relax or Get Active#8601731 BR 1 BA Sleeps 4$302 avg/night1-3 night min stay
1 BR 1 BA Sleeps 4$280 avg/night1-3 night min stay
Stress Free Studio - Located Just Behind Downtown Siesta Village and 1 Block from the #1 Beach!#8601812 BR 1 BA Sleeps 6$367 avg/night1-3 night min stay
2 BR 1 BA Sleeps 6$132 avg/night7 night min stay
Buttonwood 935#3957868ha2 BR 2 BA Sleeps 6$184 avg/night7 night min stay
Siesta Key- La Siesta Condos- Third Floor 2b/2b Unit; Open Kitchen; Newly Renovated Master Shower#4233697ha2 BR 2 BA Sleeps 6$138 avg/night7 night min stay
2 BR 1 BA Sleeps 6
1 BR 1 BA Sleeps 4$297 avg/night1-3 night min stay
2 BR 1 BA Sleeps 5
Luxurious Living by Siesta Beach in This Renovated 2b/1b Ground Floor Unit with Custom Decorations#4233684ha2 BR 1 BA Sleeps 6
1 BR 1 BA Sleeps 4$304 avg/night1-3 night min stay
1 BR 1 BA Sleeps 4$245 avg/night1-3 night min stay
1 BR 1 BA Sleeps 4$267 avg/night1-3 night min stay
2 BR 2 BA Sleeps 6$168 avg/night7 night min stay
2 BR 1.5 BA Sleeps 4$189 avg/night7-14 night min stay
2 BR 2 BA Sleeps 5$164 avg/night31 night min stay
3 BR 2 BA Sleeps 6$129 avg/night14 night min stay
Luxury Beach Cottage#213515ha1 BR 1 BA Sleeps 2$271 avg/night7 night min stay
2 BR 1 BA Sleeps 4$125 avg/night4-7 night min stay
1 BR 1 BA Sleeps 4$64 avg/night30-31 night min stay
2 BR 2 BA Sleeps 6$121 avg/night4-7 night min stay
2 BR 2 BA Sleeps 4$120 avg/night5-30 night min stay
1 BR 1 BA Sleeps 4$125 avg/night7-14 night min stay
Private Tropical Retreat!#5615182 BR 2 BA Sleeps 4$107 avg/night14-30 night min stay
2 BR 1.5+ BA Sleeps 4$103 avg/night30 night min stay
2 BR 2 BA Sleeps 6$130 avg/night29 night min stay
3 BR 2.5 BA Sleeps 8$231 avg/night3-7 night min stay
2 BR 2 BA Sleeps 7$221 avg/night14 night min stay
2 BR 2 BA Sleeps 6$179 avg/night7 night min stay
Other areas nearby to Siesta Key:
Recent Siesta Key reviews
"We enjoyed our stay at House of the Sun so much we didn't want to leave. Great location, Amazing Condo,had everything anyone could need. So well stocked, so clean and so pretty, We felt right at home. And so close to everything . We love Capitan Kurt's and the Sniki Tiki and all we had to do was walk across the road. And just a few steps to the wonderful beach.We took my 80 and 83 year old parents along and was so easy for them to get to the beach and to the car , They had a great time. Love this place and can't wait to go back...."Guest: Pamela Date of Stay: May 2016 Review Submitted: June 6, 2016View listing
"We love Siesta Key, it is our favorite vacation spot and this townhouse was the best place that we have stayed so far!!! It was very quiet, peaceful, and accommodating with plenty of amenities to feel like home!!! It was very convenient to the beach right across the street, the pool and grills were great too!!! Can't wait until next year!!!"Guest: Shae S. Date of Stay: June 2016 Review Submitted: June 22, 2016View listing
"We have been renting this unit for several years now. We keep coming back because Michael and Lelia spend much effort keeping the condo clean, well furbished and providing everything one needs to feel at home. This ground floor condo has a second (back door) access to the grounds and the pool. It`s close to the office, laundry and beach access. Lots to do on the island; many restaurants, grocery stores and shopping close by."Guest: MJ & PC Date of Stay: January 2016 Review Submitted: April 12, 2016View listing
"The condo was very clean, the beds were comfortable, and it had everything we needed. The complex was very quiet and peaceful. We only used the pool once but it was great, and there was typically no one or very few people in it. It is close to the village with many restaurants and shops. Captain Curts to the south was very good as well. The only minor issue was the closest access to the beach was good ways down the road, and no parking. However, we discovered the many shuttle services available that work strictly for tips, and they will pick you up and drop you off right at the beach. Beach Access #7 seemed to be the least crowded and worked well for us. The shuttle is definitely worth a few bucks! Overall a great stay and the owner was very nice and helpful. Would stay again."Guest: Coby S. Date of Stay: May 2016 Review Submitted: June 9, 2016View listing
Featured Destinations: Dauphin Island, Isle of Palms, Bald Head Island, Destin Condo Rentals


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|Brand Name
|Item model number
|Item Weight
|15.2 ounces
|Product Dimensions
|7.2 x 0.7 x 10.1 inches
|Item Dimensions L x W x H
|7.2 x 0.67 x 10.08 inches
|Black with Spanish keys
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Logitech Ultrathin Keyboard Cover Black for iPad 2 and iPad (3rd generation) with English and Spanish keys
|$26.95 & FREE Shipping on orders over $49. Details
|You Save:
|$10.00 (27%)
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- Enter your model number to make sure this fits.
- Clip-and-go design: Magnetic clip instantly attaches the keyboard cover securely to your iPad 2 and iPad (3rd Generation)
- Versatile iPad stand: Holds your iPad 3 at the optimum viewing angle in either portrait or landscape position
- Instant on/off: Automatically wakes and sleeps your iPad when you open and close the cover
- Color Black
- Designed to work for both languages, Spanish and English
Fulfillment by Amazon (FBA) is a service we offer sellers that lets them store their products in Amazon's fulfillment centers, and we directly pack, ship, and provide customer service for these products. Something we hope you'll especially enjoy: FBA items qualify for FREE Shipping and .
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Product Description
Customer Reviews
Top Customer Reviews
|Length: 5:11 Mins
When you open your iPad, you can either use the keyboard as is, or you can detatch the cover from your iPad and put our iPad into the perfectly positioned iPad holder, in either landscape or portrait position.
The keyboard is setup primarily for Spanish because the actual imprints on the keys are geared to Spanish keyboard mapping and not English. Specifically, the alphabet keys are mostly normal, but the number keys have different character mapping than you would be accustomed to when compared to English language key mapping.
On the right side of the keyboard is a MicroUSB port for charging the internal battery. A MicroUSB to USB charging cable is included. It takes 4-6 hours to fully charge the battery but then you can expect up to 6 months battery life when the keyboard is used an average of 2 hours per day. The on/off switch has no indication, other than the LED light on the face of the keyboard, to which position is on or off. There's also a bluetooth button to initiate pairing mode.
The keyboard is thin and very light. It works really well and I think it is a superior bluetooth keyboard. And it's mapped for Spanish but can also be used for English. However when used as an English keyboard, the character mapping is not obvious because the keys are marked for Spanish mapping not English.
Overall this is a wonderful bluetooth keyboard/cover for your iPad 2 and iPad 3.Read more ›
ad best. This is like a young immature version of a keyboard. The keyboard does hold the i`pad in the right position better, but there is no protective case, only a looslely magnetically attached use of this keyboard as a sort of turtle shell leaving one side of the ipad exposed. `i want to like it but look at the mistakes and this is me trying extra hard to make good type. `i really don't like the initial repetitiion of keys in sentences, as i almost have to fogo back and retype every initial capital letter. `it's strange that it's not a standard keyboard setup.
The function is great, the keys feel nice, and the battery life is many days or weeks. If you use the keyboard with the language set to Spanish, it works as labeled and is still a great keyboard.
As you may already know, there are some things to keep in mind if you get this. It's not a case. It does use both the magnet for covers on the ipad and that keeps it attached on that side. However, the other side isn't latched in any way, so if you are carrying it, you will need to hold both parts or it could flap open. Otherwise, the finish matches the ipad, and it looks like one piece. When you want to use the keyboard, you pull the ipad off of the magnet hinge and set it in a groove that holds it up. The nice part, is that it's sturdy and you can set it in vertical or horizontal mode.
Also, I live in Mexico and have a Spanish keyboard, so I do know the keystrokes without looking.. For a person who is typing in English it must be a problem.
Other than that I love the keyboard.
Customer Images
Most Recent Customer Reviews
Not what I expected but it works fine. However several of the keys are marked incorrectly. THE QUESTION MARK IS LABELED AS - DASH AND UNDERSCORE...Published 1 month ago by jaime chandra
Not at all satisfied with this product. It's always a scavenger hunt when looking for the keys in need for proper English punctuation.Published 4 months ago by Bookerthewriter
It has been 2 years since I bought this keyboard and I use it almost everyday. It is very lightweight and easy to use. Read morePublished 5 months ago by Sonia
The item itself isn't bad, if you learned to type in Mexico (?). The problem is likely I ordered this keyboard without reading the description carefully enough (Spanish... Read morePublished 6 months ago by R. Potter
It arrived ON TIME ON A SUNDAY and I was pleased with that as well as with the function of the keyboard.Published 6 months ago by Razz51
I ordered this for my son and he is absolutely delighted with it.Published 6 months ago by Lucille M. Martel
The descriptions of this keyboard on this page and on the box are completely misleading. If you are looking for a mainly Spanish layout keyboard this is great. Read morePublished 7 months ago by E_mu


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GLOBAL MARKETS-Asia shares slip, yen gains as uncertainty grips* Japanese yen creeps higher as market second guesses BoJ * Sterling slips on report BoE hawk swings toward easing * Oil prices near three-month lows on ample supply By Wayne Cole SYDNEY, July 26 (Reuters) - Caution gripped Asian markets onTuesday, sending ... Sify, 1 day ago
GLOBAL MARKETS-Japan shares slip, yen gains as uncertainty grips - Sify, 1 day ago
Nikkei rises to 7-week high on weak yen, stimulus hopes - Sify, 6 days ago
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It's a really scary number: BP's bill for Gulf oil spill reaches $61.6 billion
By , What's bigger than the value of Ford, Honda or General Motors? As big as the biggest U.S. electric utility? Eight times the size of Staples and Office Depot combined — if a judge hadn't blocked their merger? The answer: the $61.6billion ...Washington Post, 1 week ago BP's oil spill bill reaches $81b Sydney Morning Herald, 1 week ago BP's bill for the world's largest oil spill now reaches $81 billion WA Today, 1 week ago BP's big bill for oil spill Stuff.co.nz, 1 week ago
Castrol launches first re-refined Eco engine oil in India
Castrol has launched the first Eco product in its GTX range Castrol GTX Eco for diesel cars in the Indian market. Interestingly, India is the first market to get the eco engine oil. The company plans to launch the petrol variant of the same in the ...Autocar Professional, 1 week ago Castrol Launches GTX ECO Diesel Car Engine Oil Auto Tech Review, 1 week ago Castrol Has Launched The GTX Eco Engine Oil In India DriveSpark.com, 1 week ago Castrol launches GTX ECO engine oil NewsFlow24, 1 week ago
Kuwait Plans to Sell Minority Stakes in Oil-Company Units
Kuwait is taking steps to sell minority stakes in units of the state oil producer as the Middle Eastern government plans to tap global capital markets for funds and improve efficiency in its most important industry. The government has a four-year ...Bloomberg, 2 weeks ago Kuwait Plans to Sell Stakes in as Many as Four Oil-Company Units La Repubblica, 2 weeks ago Kuwait to sell stakes in oil-company units Gulf News, 2 weeks ago Kuwait to sell stakes in oil units Coordination with Saudis eyed over bond sales Kuwait Times, 1 week ago
Japan Stocks Erase Brexit Wipeout on Stimulus Bets; Oil Retreats
(Bloomberg) -- The equity revival got new life in Asia, with Japanese stocks joining the global benchmark in reversing their Brexit referendum losses on the outlook for further stimulus. Copper extended its rally, while oil fell following its best ...La Repubblica, 2 weeks ago Japanese Stocks Extend Surge on Abe Stimulus as Oil, Bonds Fall La Repubblica, 2 weeks ago Nikkei gains as markets try to fight off Brexit fears Sify, 4 weeks ago
Oil prices rise but end near 2-month lows
AFP SINGAPORE -- Oil prices recovered Tuesday but stayed near two-month lows as increased U.S. drilling, a strong dollar and hints of higher production by Iran and Libya brought worries about a global glut back into focus. The commodity has ...China Post, 2 weeks ago Oil prices near 2-month lows as investors bet on weaker prices CNBC, 2 weeks ago Oil prices rise but supply worries temper gains Yahoo! Singapore, 2 weeks ago Oil prices rise up but supply worries temper gains Free Malaysia Today, 2 weeks ago
Tide Water Oil Co (I) to hold board meeting
On 11 August 2016Business Standard, 2 weeks ago Tide Water profit dives 86% Business Line, 1 month ago Tide Water Oil Co (I) standalone net profit declines 87.26% in the March 2016 quarter Business Standard, 1 month ago Board of Tide Water Oil Co (I) recommends final dividend Business Standard, 1 month ago
U.S. oil drillers add rigs for third week in a row -Baker Hughes
July 15 (Reuters) - U.S. drillers this week added oil rigs for a third week in a row, according to a closely followed report Friday, as some producers boost spending and increase activity to capture higher prices in the future despite a recent slump ...Reuters Africa, 1 week ago
LANXESS's PA 6 Offers More Economical Design for Engine Oil Pan
COLOGNE -- The trend of manufacturing engine oil pans from plastic instead of metals such as aluminum is continuing to gain ground. For historical reasons, the plastic of choice to date has almost always been polyamide 6.6. However, newer designs ...Omnexus - SpecialChem, 1 week ago New use of polyamide 6 helps cuts weight of engine oil pan Autocar Professional, 2 weeks ago
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* News of truck attack in France bolsters safe-haven yen * Crude oil futures give back some of Thursday's surge TOKYO, July 15 (Reuters) - Asian shares rose to eight-monthhighs on Friday, on track for solid weekly gains, as recordhighs on Wall Street offset ...Sify, 1 week ago Asian shares rise to eight-month highs, on track for weekly gains Sify, 1 week ago Asian shares rise, Europe seen subdued after Nice attack Sify, 1 week ago GLOBAL MARKETS-Asian shares rise, Europe seen subdued after Nice attack Sify, 1 week ago
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I am an experienced trial lawyer, and, frankly, I am dismayed with the negative advertisements and mailers about three of our Tennessee Supreme Court Justices. These mailers talk about the Justices being liberal and tie them to Obamacare. Clearly, this propaganda attempts to focus attention away from the Justices themselves to political subjects sensitive to many Tennesseans.
The Tennessee Supreme Court is not political—it is fair and non-partisan. The Tennessee Supreme Court does not handle federal matters—no issue related to Obamacare has ever been presented to our State Supreme Court as that Court cannot by law rule on federal matters.
The Justices are being attacked not on the basis of their experience or wisdom or performance on the bench, rather they are being attacked because of someone else's agenda.
Our Courts were intended and created to be separate, fair, and impartial, without partisan politics. The Judges and Justices take an oath to uphold the Constitution of our State, and of the United States. The Appellate Courts, including the Tennessee Supreme Court, interpret law based on existing law and the Constitution.
Each of these Justices, Chief Justice Wade, Justice Connie Clark, and Justice Sharon Lee, have been held by a performance evaluation commission to be properly doing their jobs, and to be qualified to continue or be retained as Supreme Court Justices.
Do not be misled—it is easy to make broad or negative statements about someone. Please educate yourself on the issues and vote to retain our Tennessee Supreme Court Justices.
Jennifer H. Lawrence
Lawrence & Lawrence, PLLC
* * *
I served in the Judicial System with all of the judges being falsely attacked by those with a political agenda. Judge Wade is an extremely competent, fair and personable Chief Justice. Connie Clark served as a trial judge, Administrator of the Courts, and on the Supreme Court. She is fair and impartial and has done a good job. Sharon Bell served well on the Court of Appeals before being appointed to the Supreme Court.
I hope our voters can see this is an attempt by some in the legislative department to obtain control of the Judicial Department.
Please do not allow politics to affect the administration of justice. Vote to retain those Supreme Court Judges.
Vann Owens
Retired Chancellor, 11th Judicial District
I have personally known Connie Clark for 50 years. She has worked hard to obtain the skills needed to be a Supreme Court Justice. Connie has been blessed with a brilliant analytical mind, and a strong sense of responsibility to use the gifts that have been given to her. Connie has applied these gifts daily with her family, professionally, in her community and church. I trust her judgement without question.
Connie has a deep respect for the law and not one time has she ever acted as if she is above the laws of our state or country. We should feel confident that the laws passed by our elected officials will be applied fairly to each case presented to the court. The review of Connie's work by the committee appointed last fall by Lt. Governor Ramsey gave Connie an excellent rating. This proves that Connie's deep respect for the law is applied with each decision she has to make daily.
I believe the voters of this state need to step up and vote to retain Justice Clark, Lee,and Wade. All three Justices received an excellent review by Ramsey's committee. The retention of these Justices will insure the separation of the branches of the Tennessee government.
Karen Corn Baxley
July 23, 2016
July 22, 2016
I am flabbergasted. A 15-year-old young lady was raped by a bus driver, to whom we have entrusted our young, and all he gets is a suspended sentence and a GPS ankle bracelet. Really? ... (click for more)
As of Friday afternoon, there was a one-year-old girl in Birmingham clinging to her life after she was absent-mindedly left in a parked car this week. With an outside temperature in the mid-90s, ... (click for more)
We all know there are problems with the management of our school system. Fortunately for District 2, Jonathan Welch is not one of them. In the last four years, Jonathan Welch has ... (click for more)
I am flabbergasted. A 15-year-old young lady was raped by a bus driver, to whom we have entrusted our young, and all he gets is a suspended sentence and a GPS ankle bracelet. Really? What judicial idiot, in their "judicial wisdom," felt that sentence was appropriate? Via the Disciplinary Counsel of the Supreme Court of Tennessee- Administrative Office of the Courts, ... (click for more)
As of Friday afternoon, there was a one-year-old girl in Birmingham clinging to her life after she was absent-mindedly left in a parked car this week. With an outside temperature in the mid-90s, it is estimated the inside temperature in a locked automobile will be over 140 degrees so please know our Good Samaritan laws give you "a free pass" to bash a window out if you see an infant ... (click for more)
A man who spent most of his 20s in Georgia state prison is headed to federal prison at age 30. Leighton L. Dunn on Friday was sentenced by Judge Travis McDonough to serve 58 months for being a felon in possession of a gun during a carjacking. Dunn told the judge, "I was released in March (2015) and was doing good, then I fell in that same rut. Before I knew it I was caught ... (click for more)
Brandon Jamal Appleberry, 27, was arrested on Monday after an altercation with an employee at Southside Grocery on West 38 th Street, officers said. Marty Witt, 44, told police that the suspect confronted him with a gun in his hand. Officers said security video from the store clearly showed Appleberry arguing with several people outside while holding a gun. The defendant ... (click for more)
(Story will be updated) Saturday was another record-setting day for runners in Chattanooga. The occasion was the second running of the Scenic City Scorcher, a flat and fast two-mile race in Heritage Landing. Christian Thompson and Rachel Mason were overall winners and both did so in record-breaking time. Thompson was all alone in first with a time of nine ... (click for more)
Chattanooga Christian School announced that Coach Eddie Salter is returning to the men's basketball program as the Varsity Head Coach for 2016-2017. He will be joined by Chattanooga Christian alumnus, Ben Wharton, who has been named the Varsity Head Coach of the men's baseball program and the Junior Varsity Men's Basketball Coach. Former Varsity Head Basketball Coach ... (click for more)


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It's been quite a presidential week in the Land of the Free. Monday, Barack Obama was sworn in on Capitol Hill for a second term, and last night, former Republican candidate Newt Gingrich was bestowed an equal — if not greater — honour inside Snooki's delivery room.
As the length between her contractions shortened on last night's Snooki & JWOWW," the guidette's anxiety skyrocketed. Please, don't let me poop, she prayed. Fake eyelashes impressively intact, Snooks clutched her dear plush elephant, which had recently replaced Crocadilly as her stuffed animal of choice, and, you guessed it, just so happened to be a gift from the silver-haired fox, himself, Newt G. "I held it the whole time I gave birth, so he should feel really cool," Snooks says in the "Tea Time" after show clip below. And he should. In a way, it's as if the man was right there for Lorenzo's birth! You know, like, in spirit animal form? (Calls to Mr. Gingrich's office for comment were not returned by press time.)
So that's how the politician was once quoted as saying "There's a large part of me that's four years old… I wake up in the morning and I know that somewhere there's a cookie" provided comfort to Nicole Polizzi during the most monumental event of her life. The end.
Are You Ready?!Read More
A New Twist Means Up To Three Finalists Could Go Home Completely Empty-HandedRead More
Meet Yung MommyRead More
The 'Hills' Alum Doled Out A Lottttttttttttt Of Cash For His Precious MineralsRead More


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Darrin Hofmeyr
July-August 2009
Commercial done for Garmin at BlackGinger.
Filmed in Hazyview, Mpumalanga.
Directed by Slim of Egg films.
CG Supervisor - Darrin Hofmeyr
Flame - Eddie Addinall
Modeling - Francois Conradie, Hayden Barnett
Texturing - Kirsten Beets
Rigging - Duncan Greenwood
Animation - Richard Clark, Andre de Villiers, JC Phillips, Darrin Hofmeyr
Shading - Jason Slabber
VFX - Kyle Ueckermann
Lighting - Jason Slabber, Wayne Berry, Camille Naude


text:
Written on: 21/08/2013
Travel Republic went above and beyond when I had to change my booking from 2 adults to one. They had no problem doing this for me and sent me e-mail confirmation each time.
There was nothing that I did'nt like about my experience booking with Travel Republic they were all very helpful
As rated by our community of reviewers
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As a writer/editor with over 25 years of experience, and an MA in Communications/Public Relations and a BA in English, I have enjoyed writing and editing for print and the Web. College entrance essays, personal communications, newspaper articles, webpages, business writing, master degree theses, an...
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$12.99The author behind 1000awesomethings.com celebrates the good things in life- by the sheer power of their awesomeness. Based on the award-winning blog 1000awesomethings.com, The Book of Awesome is a high five for humanity and a big celebration of life's little moments and the underappreciated, simple things that make us happy, from popping bubble wrap to hitting a bunch of green lights in a row, to
The Book of (Even More) AwesomeIT ONLY GETS AWESOMER Neil Pasricha of 1000awesomethings.com presents a brand-new collection of things that make you go AWESOME!... When a baby falls asleep on you The first couple hours of the road trip The smell of Play-Doh The sound of snow crunching under your boots
$12.99There's nothing like the holidays. They bring out the best, and sometimes the worst, in everyone. Luckily, Neil Pasricha is here to remind us that not only are the holidays great, but there's actually even more to celebrate than we realize. From Christmas, Hanukkah, and Kwanzaa, to other holidays throughout the year, such as Mother's Day and Thanksgiving, The Book of (Holiday) Awesome will show
$10.99A stunning first picture book from the New York Times bestselling author of The Book of Awesome. Are you ready? With the simple touch of your fingers go on a stunning interactive journey to see the world as you never have before. Fly through wispy clouds, dive deep into the sparkling ocean, feel wet grains of sand on a hot and sunny beach... You will discover you can fly your mind to anywhere
Want Nothing + Do Anything = Have Everything#1 INTERNATIONAL BESTSELLERWhat's the formula for a happy life? Neil Pasricha is a Harvard MBA, a Walmart executive, a New York Times–bestselling author, and a husband and dad. After selling more than a million copies of his Book of Awesome series, he now shifts his focus from observation to application.In The Happiness Equation, Pasricha illustrates how to want nothing, do anything, and have
The Secrets of Being Productive in Life and BusinessNEW YORK TIMES BESTSELLER • From the author of The Power of Habit comes a fascinating book that explores the science of productivity, and why managing how you think is more important than what you think—with an appendix of real-world lessons to apply to your life. At the core of Smarter Faster Better are eight key productivity concepts—from motivation and goal setting to focus and decision making
Bringing Your Boldest Self to Your Biggest ChallengesHave you ever left a nerve-racking challenge and immediately wished for a do over? Maybe after a job interview, a performance, or a difficult conversation? The very moments that require us to be genuine and commanding can instead cause us to feel phony and powerless. Too often we approach our lives' biggest hurdles with dread, execute them with anxiety, and leave them with regret. By accessing our
The Life-Changing Magic of Not Giving a F*ck
How to Stop Spending Time You Don't Have with People You Don't Like Doing Things You Don't Want to DoTHE "GENIUS" (Cosmopolitan) NATIONAL BESTSELLER ON THE ART OF CARING LESS AND GETTING MOREAre you stressed out, overbooked, and underwhelmed by life? Fed up with pleasing everyone else before you please yourself? It's time to stop giving a f*ck. This brilliant, hilarious, and practical parody of Marie Kondo's bestseller The Life-Changing Magic of Tidying Up explains how to rid yourself of unwanted
How Non-Conformists Move the WorldThe #1 national bestseller and New York Times bestseller that examines how people can champion new ideas—and how leaders can fight groupthink"Reading Originals made me feel like I was seated across from Adam Grant at a dinner party, as one of my favorite thinkers thrilled me with his insights and his wonderfully new take on the world." —Malcolm Gladwell, author of Outliers and The Tipping Point
A Memoir by the Creator of NikeIn this candid and riveting memoir, for the first time ever, Nike founder and board chairman Phil Knight shares the inside story of the company's early days as an intrepid start-up and its evolution into one of the world's most iconic, game-changing, and profitable brands.Young, searching, fresh out of business school, Phil Knight borrowed fifty dollars from his father and launched a company with
$9.99"My predominant feeling is one of gratitude. I have loved and been loved. I have been given much and I have given something in return. Above all, I have been a sentient being, a thinking animal, on this beautiful planet, and that in itself has been an enormous privilege and adventure." —Oliver SacksNo writer has succeeded in capturing the medical and human drama of illness as honestly and as
$13.99#1 NEW YORK TIMES BESTSELLERWhen we deny our stories, they define us. When we own our stories, we get to write the ending. Social scientist Brené Brown has ignited a global conversation on courage, vulnerability, shame, and worthiness. Her pioneering work uncovered a profound truth: Vulnerability—the willingness to show up and be seen with no guarantee of outcome—is the only path to more love,


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Star Tracks
How does Law take cover from the cold? In a down jacket, an apron and the local newspaper. Plus: Tyra, Uma and more
Credit: Jack Ludlam/Splash News
Published: Tuesday Mar 06, 2007 | 05:10 PM EST
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