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Where to Stay
Bangkok is one of the top spots in the world to splurge on 5 star lodgings. Take your pick between elegant old hotels along the Chao Phraya River or swanky new, cutting edge digs around Silom Road and the city center. The best lodging choices here all offer sumptuous buffet breakfasts, sky bars, and world-class restaurants to go with the premium sleep. The river area is the most relaxed and atmospheric part of the city, whereas the central areas offer quick access to the BTS Skytrain along with a dizzying variety of eating and nightlife all around.
Book ahead for Christmas and New Year, the most crowded time here.
Hotels not on the Skytrain line or with access to the river ferry system, as you will spend a lot of time in traffic
Last-minute Internet booking can yield some great finds with all the hotel competition in Bangkok.


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The Lubbock High, Coronado and Estacado boys basketball teams will start tournament action today at the Key City Tournament in Abilene.
The Westerners will open with Randall at 8:30 a.m., while CHS will face Kingwood at noon. Estacado will start the tourney against Arlington Martin at 10:15 a.m.
Coronado and Lubbock High's girls teams will eschew tournament play this weekend and instead play single-game contests today. CHS will face Merkel on the road at 7 p.m., while the Lady Westerners will play Plainview at home at 6 p.m.
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subset: commoncrawl


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Tools of the Trade
A hammer and a saw used to be the key tools for home contractors. Today, the best-in-breed also use high-tech equipment while performing a professional energy audit or verifying that construction has been done correctly.
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What is a direct proof of isoperimetric inequality? In another word, i am asking for a proof that the circle has the maximum area compare to other geometric shape with the same circumstance but without the assumption that the circle is the "optimal choice".
Could anybody answer?
Comment 1: i think the circle S1 absolutly comes from nowhere, then immediatialy substitude some type of inequality...
Here is the elemetary indirect proof from Do Carmo's Differential Geometry:
Page 1 of the indirect proof: http://i.stack.imgur.com/UXDnD.png
page 2: http://i.stack.imgur.com/FuHnA.png


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This question already has an answer here:
I am using Ubuntu 12.04 and I was doing through a terminal tutorial. There was explained about
echo command and he mentioned something about adding your name to the
sudoers file using
echo >>. I am just wondering what it was? Can anyone tell me how to do it?


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PaganSquare is a community blog space where Pagans can discuss topics relevant to the life and spiritual practice of all Pagans.
Recently I wrote about the role music played in how I became a Pagan. I ended my story with the summer solstice of 2012, which marks the beginning of my Pagan path. The feeling of having come home, so familiar to many Pagans, took me by surprise that night and has stayed with me ever since.
The four elements are found throughout philosophy, myth and literature, in addition to being foundational for both magical work and Tarot.
But what do they mean? What does the energy of each feel like? How are the four elements expressed in the real world (apart from literal manifestations in movies like The Last Airbender)?...


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(**UPDATED with winners - and some explanation/analysis)
Predicting how the Hollywood Foreign Press Association will vote for may be the toughest prediction to make during the entire Award Season.
Several recent Golden Globe nominees have obviously been nominated by international reputation alone (Johnny Depp for 'Alice in Wonderland' and 'The Tourist' in the same year and the same category). While several other Golden Globe winners failed to even receive an Academy Award nomination: Paul Giamatti ('Barney's Version') or Ben Affleck ('Argo').
This year's field of nominees is a tough field to call. In fact, the only category that appears to be a lock is 'Best Actress in a Drama.' There's only one clear winner here – you can take a bet on this pick.
That said - here are my picks for who should and who will win Golden Globe Awards for feature films tonight:
Final scorecard: 7.5 correct predictions out of 11 predicted categories - earned 1 pt for each correct 'will win' and earned 0.5 'should win' picks ... nailed six predictions ... got three predictions sort-of-right with 'should win' picks ... got two categories absolutely and completely wrong ('Lead Actor in a Comedy' and 'Foreign film') .
Best Motion Picture - Drama:
- 12 Years a Slave (should win) (WINNER)
- Captain Phillips
- Gravity (will win)
- Rush
- Philomena
** Post-Golden Globes thoughts: '12 Years A Slave' seemed too 'American' a premise and story for the HFP to pick, while 'Gravity' is universally thrilling and heart-stopping in any language. Furthermore, 'Gravity' boasts a $405 million international box office (not counting its $256 m US box office) - while '12 Years a Slave' has only $38.9 m in the US. '12 YAS' may be the Best Picture frontrunner, but it's not the clear Oscar favorite yet - 'Gravity,' 'Inside Llewyn Davis' and 'Her' are just behind.
Best Motion Picture - Comedy or Musical:
- American Hustle (will win) (WINNER)
- Her (should win)
- Inside Llewyn Davis
- Nebraska
- The Wolf of Wall Street
** Post-Golden Globes thoughts: 'American Hustle' was the only obvious pick for this award. It boasts the biggest, most prominent all-star cast and is stronger than most of these films ... except 'Her.'
Best Performance by an Actor in a Motion Picture - Drama:
- Chiwetel Ejiofor for '12 Years a Slave' (will win)
- Idris Elba for 'Mandela'
- Tom Hanks for 'Captain Phillips'
- Matthew McConaughey for 'Dallas Buyers Club' (should win) (WINNER)
- Robert Redford for 'All Is Lost'
** Post-Golden Globes thoughts: 'Dallas Buyers Club' is an acting movie - now legitimized by its two prominent stars (McConaughey & Jared Leto) winning Golden Globe awards. But the Lead Actor category remains the most challenging - and McConaughey will still have to deal with Ejiofor, Bale, Dern and Issac in the Oscar category.
Best Performance by an Actress in a Motion Picture - Drama:
- Cate Blanchett for 'Blue Jasmine' (should & will win) (WINNER)
- Sandra Bullock for 'Gravity'
- Judi Dench for 'Philomena'
- Emma Thompson for 'Saving Mr. Banks'
- Kate Winslet 'Labor Day'
** Post-Golden Globes thoughts: Blanchett is the clear winner in this category at every ceremony this Award Season. In fact, it will be a surprise if she doesn't win the Oscar. But Thompson still has an outside shot for the Lead Actress Oscar.
Best Performance by an Actor in a Motion Picture - Comedy or Musical:
- Christian Bale for 'American Hustle' (will win)
- Bruce Dern for 'Nebraska' (should win)
- Leonardo DiCaprio for 'The Wolf of Wall Street' (WINNER)
- Oscar Isaac for 'Inside Llewyn Davis'
- Joaquin Phoenix for 'Her'
** Post-Golden Globes thoughts: The Golden Globes has had a number of their 'Lead Actor-Comedy' award winners not receive an Oscar nomination. DiCaprio - while fine in WoWS - did not deserve this win and he may not even be nominated for an Oscar. DiCaprio won this award based on name recognition and the broad appeal of his performance.
Best Performance by an Actress in a Motion Picture - Comedy or Musical:
- Amy Adams for 'American Hustle' (should & will win) (WINNER)
- Julie Delpy for 'Before Midnight'
- Greta Gerwig for 'Frances Ha'
- Julia Louis-Dreyfus for 'Enough Said'
- Meryl Streep for 'August: Osage County'
** Post-Golden Globes thoughts: Amy Adams was the only clear winner for this award. Streep would only have won based on her name recognition - not her performance in another wise lame movie. Adams may receive an Oscar nomination - but she'd be up against the unstoppable Cate Blanchett.
Best Performance by an Actor in a Supporting Role in a Motion Picture:
- Barkhad Abdi for 'Captain Phillips' (should win)
- Daniel Brühl for 'Rush'
- Bradley Cooper for 'American Hustle' (**could win)
- Michael Fassbender for '12 Years a Slave'
- Jared Leto for 'Dallas Buyers Club' (will win) (WINNER)
** Post-Golden Globes thoughts: Leto has all the momentum in Award Season to take the Supporting Actor Oscar. But Abdi's performance still has the greatest range. That said, Leto's performance has the greatest depth of anyone in this category.
Best Performance by an Actress in a Supporting Role in a Motion Picture:
- Sally Hawkins for 'Blue Jasmine'
- Jennifer Lawrence for 'American Hustle' (will win) (WINNER)
- Lupita Nyong'o for '12 Years a Slave' (should win)
- Julia Roberts for 'August: Osage County'
- June Squibb for 'Nebraska'
** Post-Golden Globes thoughts: Jennifer Lawrence also has momentum - and she's carrying over a lot of that momentum from her Best Supporting Actress run last year. She is America's new sweetheart - and her talent will make her force to be reckoned with in the years to come. But J-Law still has one strong competitor in the field: Nyong'o. The Best Supporting Actress race will be a rematch of these two leading contenders.
Best Director - Motion Picture:
- Alfonso Cuarón for 'Gravity' (should & will win) (WINNER)
- Paul Greengrass for 'Captain Phillips'
- Steve McQueen for '12 Years a Slave'
- David O. Russell for 'American Hustle'
- Alexander Payne for 'Nebraska'
** Post-Golden Globes thoughts: Cuarón crafted a frenetic, heart-stopping, intense film. Every watt of kinetic energy in 'Gravity' comes from his masterful direction.
Best Screenplay - Motion Picture:
- American Hustle (will win)
- 12 Years a Slave
- Her (should win) (WINNER)
- Nebraska
- Philomena
** Post-Golden Globes thoughts: While the smart money was one the witty, sharply written 'American Hustle' - the HFP smartly picked the poetic and beautifully written 'Her.'
Best Foreign Language Film:
- The Past
- The Hunt (should win)
- Blue Is the Warmest Color (will win)
- The Great Beauty (WINNER)
- The Wind Rises
** Post-Golden Globes thoughts: 'The Great Beauty' is pretty much a lock for the Best Foreign Film winner at the Academy Awards. Neither 'Blue is the Warmest Color' nor 'The Past' made the list of 10 films still eligible for the Best Foreign Film Oscar category. This is important because most 'best foreign film' awards this year have gone to 'The Past' or 'Blue.' The only legitimate competition standing between 'Beauty' and the Oscar is the incredible thriller 'The Hunt.'


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Bigger is better
The more research I do on Bill Parcells and his crew, the more confident I've become that the Dolphins will either pick Glenn Dorsey with the No. 1 overall pick, or trade the selection for a bunch of first day picks IF the price is right.
The one unit more than any Parcells is infatuated with is the defensive line I'm told. If he and the Cowboys – oh, I mean Dolphins – scouting department determines Dorsey is a "can't miss" prospect, he'll use it on the LSU standout, as long as Dorsey doesn't have many character flaws.
Dorsey (CLICK HERE FOR A STORY ON HIM) already gets one positive check from Parcells by proving he's tough enough to play through a serious knee injury. Hint, I'm told durability is high on the crews check list.
As I detailed in my story on Parcell's talent laws to live by (CLICK HERE), he's BIG on size. Absolutely can not get enough! He wants it at every position, from quarterbacks (to see over the line – John Beck's pretty short), offensive linemen (to shield the play-action and screens – free agent Rex Hadnot's also pretty short), to cornerbacks and receivers.
"Me and him have a running joke that if he took that Tampa job [back in 1996] we would have never won the Super Bowl when we did," Keyshawn Johnson said. "It would have took us longer because he would have come in and picked on all the little linebackers, and little cornerbacks we had till they left, or he got rid of them."
Johnson voluntarily mentioned Ted Ginn Jr., hinting that Parcells wouldn't have drafted him. He backed that statement up by saying it took Parcells a looooong time to warm up to Terry Glenn, whom Parcells once infamously referred to as "she."
As for Johnson, I could totally tell it wouldn't be hard for Parcells to talk him into playing if the price is right. But Johnson left our conversation with one warning: "Don't be writing I'm coming back to playing."
I couldn't help but think about Zach Thomas when discussing Parcells' infatuation with size, but I'd say this on Thomas' behalf. FILM DOESN'T LIE, and his film over the years – including this season – speaks volumes.
Thomas will likely get paroled (cut) because of his bloated contract, and don't be surprised if he catches on with a contender. He's not ready to hang it up, and I believe there's still plenty of value left in him.
As for his brother in law, unless Jason Taylor starts kicking and screaming for a trade, I suspect he'll return next season because of Parcells' never ending search for the next Lawrence Taylor. JT is pretty darn close to LT, and he'll at least buy the scouting department a year to find the Dolphins another pass rushing demon.
Parcells not only likes size, but he's a stickler for character, which made me conclude Ricky Williams should be viewed more as a poker chip than building block. Quincy Carter really burned the Cowboys and taught Dallas' scouting staff a huge lesson on thoroughly exploring all red flags.
As for what people have been saying about the Dolphins over the past few drafts, Larry Lacewell, who ironically gave former Dolphins coach Jimmy Johnson his first college job as an assistant at Wichita State back in 1967, said the Dolphins prior regimes have been: "a confused, convoluted group."
Lacewell, who still consults with the Cowboys, is confident about two things regarding Parcells. He'll be heavy-handed no matter what his role is, and he'll get the Dolphins going in the right direction.
How good depends on one thing he said.
"All they got to do is fine them a Tony Romo and they'll get real good real quick," Lacewell said with a chuckle.


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Register with us or sign in
From 0 ratings
Plant type
Half-hardy annual
Dramatic foliage
Skill level
As tropical gardening has increased in popularity, so too has this striking, dark purple-leafed plant. It has vigorous, upright and spreading purple leaves and stems that arch over the edge of containers and are excellent when used as mid-height bedding in a summer border. The plant will grow in both sun and shade but it performs best and has darkest foliage in full sun. It can also be grown from seed: sow the seeds indoors about 10-12 weeks before the last frost date.
Genus: Alternanthera
Species: dentata
Cultivar: Purple Knight
Plant type: Half-hardy annual
Foliage colour: Purple
Feature: Dramatic foliage
Sun exposure: Full sun
Soil: Well-drained/light
Hardiness: Tender
Skill level: Experienced
Height: 50cm
Spread: 50cm
Be the first reader to review the Alternanthera dentata 'Purple Knight' Alternanthera!


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Three-person crew to operate the station and provide support during station replenishment and assembly missions Progress M-44, Progress M1-6, Soyuz TM-31, Soyuz TM-32 vehicles and Space Shuttles flights 5A.1, 6A, 7A, 7A.1.
The flight program consisted of the following main activities:
AKA: Discovery; STS-102 (Helms, Usachyov, Voss).
First Launch: 2001.03.08.
Last Launch: 2001.08.22.
Duration: 167.28 days.
Discovery was launched on mission STS-102 (Space Station flight 5A.1) into an initial 60 x 222 km x 51.6 deg orbit. The mission was delivery of supplies and equipment, and changeout of the Expedition One and Expedition Two station crews. STS-102 carried the Leonardo Multi Purpose Logistics Module (MPLM), built by Alenia Spazio (Torino), to the International Space Station. The 6.4 m x 4.6 m cylindrical MPLM was a descendant of the Spacelab long modules. Also carried was a Spacehab/Energia unpressurized Integrated Cargo Carrier with LCA/MTSAS-A, RU, and PFCS. A sidewall adapter beam with two GAS canisters (G-783 and WSVFM) was also on board. WSVFM measured vibration during launch. Another adapter beam, probably at the rear of the payload bay, carried SEM-9. SEM-9 and G-783 contained high school microgravity experiments.
Leonardo carried 16 'racks' of equipment, including the Human Research Facility Rack (Rack 13) which allowed the astronauts to do extensive medical experiments, the CHeCS Rack (28), the DDCU-1 and DDCU-2 racks (7 and 9), the Avionics-3 (Rack 6), and the MSS Avionics/Lab (Rack 11) and Avionics/Cupola (Rack 12) racks for a total of 7 equipment racks to be installed on Destiny. Three Resupply Stowage Racks (50, 51, 52) and four Resupply Stowage Platforms (180, 181, 182 and 188) remained installed on Leonardo, with their equipment bags being individually transferred to the Station. System Racks 2, 3, 4, 5 and 8 were already on Destiny together with stowage racks 110 through 117. Each rack had a mass of 150-300 kg.
The orbiter fired its OMS engines at 1221 GMT to raise the orbit to 185 x 219 km. Discovery docked with the PMA-2 port on the Station at 0639 GMT on March 10. The LCA (Lab Cradle Assembly) was attached to Destiny's +Z side during an EVA. It was to be used on the next mission to temporarily place a Spacelab pallet on Destiny during installation of the Station's robot arm. Later, it would be the site for the main Station truss, beginning with segment S0.
The PMA-3, on Unity at the -Z nadir position, had to be moved to the port position to make room for Leonardo. An external stowage platform was attached to Destiny and the External Stowage Platform and the PFCS Pump Flow Control System were added to the port aft trunnion on Destiny. A rigid umbilical (RU) was connected to the PDGF grapple fixture on Destiny to support the Station's future robot arm. Leonardo was docked to Unity at -Z for a while so that its cargo could be transferred to the station easily; it was then be returned to the payload bay and brought back to earth.
At 0232 GMT on March 19 command of ISS was transferred to Expedition 2 and the hatches were closed. Discovery undocked at 0432 GMT and flew once around the station before departing at 0548 GMT. ISS mass after undocking was 115527 kg. The OMS engines fired for the deorbit burn at 0625 GMT on March 21, and Discovery touched down on runway 15 at Kennedy Space Center at 0731 GMT.


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I became obsessed in 2000, I have not stopped knitting since. I love working in yarn stores and I teach Knitting, Needle Felting, basic Crochet, Hand Dyeing, and Designing. My designs have been published in magazines. I also have sold designs to some yarn companies. I live with my loving and extremely understanding husband and her over flowing stash just 30 minutes from NYC.
For more information check out http://katelemmersdesigns.com
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text: I am currently in discussions with DBA and IT Security staff within my company, and am being told that the only way to securely link to our master database (MSSQL behind a firewall) to our web apps is to make a backup file, FTP the file to the web server, and run a script(s) to restore that imported backup file to a database hosted outside the firewall (and then import the data to MYSQL). I am having a hard time believing that this is the best solution. Ideally, I would like to have a two-way direct link between the master MSSQL server and a MySQL database that server web apps, and have those database sync. Can anyone point me toward such a solution, or is it true that we need to rely on FTP to cross the firewall?


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WWE Champion CM Punk has set off a firestorm with a Tweet he sent to a fan. In response to Punk's views on Amendment 1, a fan replied with a homophobic Tweet. Punk mentioned the fan's Tweet and responded by saying, "kill yourself."
Another fan scolded Punk for his comments and mentioned WWE's "Be-A-Star" anti-bullying campaign. Punk responded to them by writing, "hey moron, don't try to hide behind the be a star campaign. I am a star. I'm fighting bigots here. Zero tolerance." In response to another fan that disagreed with Punk, he told them to "drink bleach."
Mirror out of the United Kingdom picked up on the story and included footage of Punk hurling a homophobic slur at fans in Australia last summer. Below is the footage from a WWE live event on July 4, 2011 in Adelaide, Australia:
At the time, the comments caused considerable controversy and Punk issued the following apology:
I'm glad TMZ posted that video because everybody needs to be held accountable for their bulls—, me included. What I said was bulls—… I'm embarrassed. I own up to being a total douche in this situation and I offer a sincere apology to anybody I hurt with careless words.


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Blog Url: Mia Anstine – My Many Outdoor Adventures
Online Name or Code Name: Mia Anstine
1) Outdoor Activity of choice? Riding my horse to someplace I've never seen before. Generally this occurs when I am hunting, fishing or scouting all of which are my passion. I also enjoy photography, shooting, guiding and mentoring.
2) Outdoor Mornings. Up at 5 a.m.? 6…7…8…9…Or when the sun heats up the tent and you can't take it anymore? Say what?! I don't see an appropriate outdoor morning time in the list. An average day entails Mia waking up at 4am. When it is an "outdoor morning' it's generally 3am. We saddle the horses and we head out to hunt. When the sun comes up it is close to nap time.
3) Snicker Bar or Granola Bar on the trail? Granola bar. Generally a peanut butter one because I have to share with my loyal steed, Cowboy, aka Mr Man. His favorite are the ones in the orange wrapper… YEP! He can see the colors. <wink! wink!
4) Your Birthday is coming. What outdoor (dream) present should we all chip in to buy you this year? If you all are rich, and you are going to pitch in, I would thank you so much for buying me a dall sheep hunt. All hunts or shooting events are fabulous, but I would be most appreciative if you sent me after one with lots of curl.
5) Seven days in the Alaskan Wilderness or Seven days on a Tropical Beach? I'm pretty sure anyone who knows me knows this answer. I would head to the Alaskan Wilderness to chase moose, brown bear, caribou and (see above) dall sheep, in a heart beat.
6) What kind of Outdoor Store would you own? Any one that sells PROIS Hunting & Field apparel for women, firearms, fishing equipment, archery equipment and has shooting ranges. P.S. It would cater to women and children with out a doubt.
7) Finish this sentence: When I was a little kid, I loved to go outside and… Visit with Mother Nature. My dog and I would head out early in the day and mom wouldn't see the two of us until dark. I have so many great memories from my child hood. Running the hills or fishing the San Juan. I had the life
8 ) Do you have an Outdoor related item that is priceless to you? What is it and why? That's a toss up. I love to have my camera just so I can share adventures with everyone who doesn't get to be out there. When I am guiding, the only item I can never be with out is my bino's. They are Swarovski's and they are priceless because I can see and judge all the animals and tell a client what to shoot or not. I don't know what I would do without them. Then I need that camera again so I can take a pic of their smiling face! My Prois gear always get me close to the animals!
9) Fill in the blank. When I head outdoors I need to have__my camera__with me. It is so important to take good pictures so I can write about my adventures with my Little Gal over at the Women's Outdoor News!
10) What's the story behind your blog name? "My Many Outdoor Adventures" Life is an adventure and I like it that way. It is always new and exciting and just when you think you've got it down and know what will happen next; it changes and another adventure begins. I love life.
Courage Level Question: It's You and a Grizzly Bear face to face on the trail. Knowing yourself, will you 1) Hold your ground and see who blinks first 2) throw your gear at the Grizzly and run for your life or 3) faint on the spot?
Number 1! God willing I will have my .45 in hand, my rifle or a bow. I would stand my ground and make a shot that counts. It's always an adventure!
Be sure to check out Mia and her Many Outdoor Adventures today


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Japanese high-tech shares were among the strong gainers in Asia. Panasonic Corp. rose 5.4 percent Hitachi Ltd. jumped 6.7 percent and Sharp Corp. surged 7.2 percent.
We were up 1.62 percent, but our day is coming soon for a huge percentage gain!
Sony Corp. (6758) is sticking with a goal of turning Japan's largest TV-manufacturing business profitable this fiscal year. Sony plans to increase TV sales this fiscal year from a target of 13.5 million units in the year ended March 31, Masashi Imamura, a senior vice president in charge of home entertainment products at Sony, told reporters in Tokyo today. He didn't give a new number.
Chief Executive Officer Kazuo Hirai is focusing on high-end products, such as the ultra-high definition Bravia sets that offer resolution four times sharper than conventional models, as part of plans to revive the operation.
"Major operational reform at the unit is over," Imamura said. "We will continue to make efforts to trim costs this fiscal year. We have reduced the costs we had planned to reduce in fiscal 2012, and that will help us make the business profitable."
The company trimmed its full-year TV sales target to 13.5 million units in February from the 17.5 million projected at the beginning of the fiscal year, citing a slowing global economy. The company is reducing the number of models and cutting 10,000 jobs to lower expenses after losing about 31 percent of its market value last year.
Related article and video: Search @ techhive Sony aims to take 4K mainstream with $4999 TV, media player, download service


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Molecule Identified That Makes Fat Cells Fatter
by Dr. Reeja Tharu on July 10, 2012 at 2:19 PM Health Watch - G J E 4
A group of scientists at the University of Michigan carried out a study to understand why the fat-storing cells get fatter and takes a long time to metabolize fat in obese individuals.
Obesity is a fast becoming a world -wide phenomenon and the morbidity and mortality burden due to obesity is increasing globally at an alarming rate.
AdvertisementOrmond MacDougald and his colleagues tried to study the signals sent by fat-storing cells to each other in their effort to understand why fat cells get fatter and how people become obese.
In an array of experiments carried out on mice, the researchers revealed the presence of a molecule called Sfrp5. They showed that this molecule influences a signaling pathway known as WNT, stimulates the adipocytes (fat cells) to grow bigger and larger and suppress the rate at which fat is metabolized in the mitochondria of fat cells.
By preventing the adipose cells from producing Sfrp5, the researchers were able to prevent the mice from becoming fat quite so quickly. Despite being fed on high-fat diet, the adipocytes in these mice didn't grow large.
The research was carried out with NIH funding in the U-M Medical School laboratory of Ormond MacDougald, Ph.D., in the Department of Molecular & Integrative Physiology.
The team had realized the importance of WNT signaling in fat cell development through their previous work.
"WNT signaling plays a crucial role in regulating, and inhibiting, white fat cell growth and the recruitment of new cells to store fat," MacDougald explains. "But it appears that in obesity, Sfrp5 can interfere with that signaling, and may create a feedback loop that keeps stimulating production of more of itself."
MacDougald and his team began to zero in on the molecule Sfrp5 after several years of observing WNT signaling between adipocytes. It was observed by several groups of researchers that the amounts of Sfrp5 generated in fat tissues of obese animals were much higher.
Initially, when they bred mice that could not produce the Sfrp5, they expected to see non-obese mice that resisted obesity due to their inability to convert more cells into adipocytes and thereby store fat. But what they found was that the mice without the molecule had as many fat cells as those with the molecule, but they came with a difference - the adipocytes in the former did not grow bigger and accumulate fat.These mice did not become fat no matter how calorie- laden their diet was.
Another feature of these Sfrp5-deficient mice was that the mitochondrial genes inside the adipose cells registered a surge of activity, as a result of which fat was easily burned down for the cell's activities. It was as if the 'mitochondrial furnaces' began to work over time in the absence of these molecules.
"From our results, we believe that Sfrp5 is an important moderator of mitochondrial activity-- the first time this has been seen for the WNT signaling pathway in adipocytes," says Mori the lead author of the study "This underscores the complexity of WNT signaling," mori adds.
A look into the underlying mechanism reveals that Sfrp5 works as a decoy receptor to which WNT signals bind. This prevents them from binding to the cell surface receptors that they would otherwise bind to. When the WNT signaling is reduced, the adipose cells grow larger and don't burn fat that easily. The cells grow larger to store the accumulated fat. Then, a feedback loop is created and the cells produce more Sfrp5, creating the tendency for adipocytes to accumulate more lipid.
It may be possible for anti-obesity drugs to target the signalling pathway but, MacDougald warns that more experiments need to be carried out in mice and humans before going down the drug trail. With the world in the grip of obesity, and its related health conditions, this field of research demands immediate attention.
Mori et al; Journal of Clinical Investigation (online) 2012; July issue
Source: Medindia
PKiwis Initiate Facebook Organ Donor Scheme Newer Possible Treatment Approaches for Parkinsons Disease M
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Notation Software, Music Editor & Music Maker
Personal Composer PC-Pro. Click to download a demo! Then read my testimonal.
Whether you are a serious composer or a casual hobbyist, Personal Composer offers so much flexibility in such an easy to understand composition environment, it frees you to concentrate on your music! There is absolutely no need to read a long and confusing manual, because you will figure out 90% of the program by trial and error on your first week. Listed below, are some of the necessities any serious composer would find a requirement in a software notation music maker software package. And don't forget to visit our Online Music Store to make your purchase today!
Personal Composer Notation Software Features
- No need to bury yourself deep into confusing menus. The icons, and intuitive shortcuts make notating much quicker than you would have thought.
- Personal Composer auto positions notes at the correct beat positions for you.
- You are given the control to override any auto positioning by dragging elements wherever you wish.
- Add petite notes on the fly by highlighting a note, and pressing P on the keyboard.
- Enjoy the intuitive system of adding grace notes.
- Add slurs, ties, dynamics, lyrics and tempo changes with ease. Slurs now attach to the notes, and resize with measure adjustments and note position changes!
- Easily add, delete or drag notes by using your mouse. Your right button simply deletes a note.
- If you are connected to a midi keyboard, simply press the note or chord you wish to add. See your note or chord created in real time! Compose music even quicker with this method.
- Easily resize measures by dragging the barline with your mouse.
- Press the "insert" or "delete" key on the keyboard, to add or delete measures in real time.
- Older computer systems can run Personal Composer with impressive speed. This program is not a resource hog.


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Loggerheads Showtimes and Tickets
Read Movie Reviews about Loggerheads Write a Movie Review for Loggerheads
Release Date: 2005-01-21 (Sundance 2005)
Genre: Drama, Romance
Rating: NR
Duration: 1hr 35min
Inspired by a true story, and set in three different geographical regions of North Carolina, 'Loggerheads' follows the journey of Mark, a soft-spoken drifter in his 20s who makes a pilgrimage to a small coastal town near Wilmington in order to save the endangered Loggerhead turtles that nest on the beach in the summer. Mark's journey brings us into contact with three other characters, each at the crossroads of their lives. George is a local motel owner who, until now, has avoided dealing with his emotions. Grace, a middle-aged woman recovering from a breakdown, has returned to her hometown in the mountains near Asheville to stay with her mother. Plagued by the desire to fill an emotional void, Grace embarks on a search for the child she secretly gave up for adoption when she was a teenager. Elizabeth has lived a fishbowl existence as the wife of a minister for 25 years in a small town in the foothills of the state. When her safe, sheltered neighborhood starts to change around her, Elizabeth must decide whether to stand by her conservative husband's beliefs or take a stand on her own.
Cast and Crew
- Starring
Bonnie Hunt, Chris Sarandon, Kip Pardue, Tess Harper, Michael Kelly, Robin Weigert, Michael Learned
- Directed by Tim Kirkman
- Produced by Gill Holland
- Written by Tim Kirkman
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text: So me and my brother both have terraria and we live in the same house. With this being said, I assume that we don't need to "Port Forward" to play on the same server. My questions are: how do I start LAN with terraria? which IP do I use? Does me or my brother have to Host the server first before any of us can join, or can I just type in my IP and join?


text:
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March 29, 2013 | Vol. 94, No. 74
Submitted photo
Hurley manager Aaron Bender talks to his team Thursday at the Metrodome in Minneapolis.
MINNEAPOLIS — The Hurley Midgets baseball team had to travel more than 250 miles — and still go inside — to start its baseball season.
They were only scrimmages, against Chequamegon and Phillips, but at least there was baseball at the Metrodome Thursday in Minneapolis.
"Despite four feet of snow on the ground, we still managed to get our first baseball games in, so that's nice," Hurley manager Aaron Bender said.
The Midgets played Phillips first and the teams were tied at 0-0 through three innings with Hurley's varsity players in. The Midgets lost 5-0 in the five-inning even...
For access to this article please sign in or subscribe.
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The Nets made a case for playing all their home games in London.
During a matinee tip-off in front of a British crowd, the Brooklyn Nets dominated the Atlanta Hawks in front of an international audience. Joe Johnson and Andray Blatche paced the Nets in a 127-110 rout.
Johnson led the Nets with 29 points on 11-for-15 shooting.
"It's fun to watch and you really feed off of that, because you've been used to being that guy your whole career, so when you have a teammate who can do that, it's fun," said Paul Pierce, who scored 18 points. "I feed off of it. Teammates feed off of it. The crowd feeds off of it and the good part about is the guys want him to keep going."
The game never remained in doubt as the Nets exploded on the offensive end. The Nets tallied a staggering 38 assists on 53 field goals, but as head coach Jason Kidd always says, the defense kickstarted the offense. Although the final score looks misleading, the Nets led by as many as 31 points.
In the first quarter, the Nets suffocated the Hawks on defense and enabled some easy looks at the other end. The Nets limited two of the Hawks key scorers in Paul Millsap and Kyle Korver to a combined 6-for-23 shooting.
Johnson jumped out to another quick start with 15 points in the first quarter, and Kidd sang Johnson's praises for his effort throughout the entire season.
"Joe's been off the charts, not just the last few games, but the whole season," Johnson said. "He's been big for us. To have a player like that to be able to coach is a blessing."
Blatche added 20 points, 14 rebounds, and six assists for a Nets' offense that shot 58.2 percent from the field.
For the second time in January, the Nets blasted the third-seeded Hawks. In a weakened Eastern Conference, the Nets proved that they boast the kind of talent necessary to at least secure a higher seed heading into the playoffs.
Obviously, injuries remain a concern as the team will finish the season without center Brook Lopez, and Deron Williams continues to experiences ankle problems. Point guard Shaun Livingston continued to guide the Nets' offense, leading them to a 4-1 record in Williams' absence.
With any good luck for the remaining starters, the Nets displayed their talented makeup overseas in London.


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DC Stoddert Soccer League, Inc. is a non-profit, youth soccer organization, providing organized teams and supervised games for girls and boys ages 4 1/2 - 19 through the cooperation of parent volunteers, paid staff, the DC Department of Parks and Recreation, the National Park Service, public and private schools as well as the generous support of individual and corporate donors.
DC Stoddert Soccer was founded in 1977 to encourage the playing of soccer among Washington-area youngsters. The club initially consisted of 60 children learning together in small groups at Stoddert Elementary School in the Glover Park neighborhood, which is where the League takes its name. Since then, Stoddert Soccer has expanded and become the city's largest youth sports program. Various soccer enrichment programs are offered for boys and girls during the fall and spring seasons, and typically serve upwards of 6,000 players, 9,000 parents, 400 teams and 750 volunteers. In addition to organized leagues, Stoddert Soccer also offers a variety of clinics for players, referee training and coaching courses.
For more detailed information about the club, please contact Douglas Homer, Executive Director, at (202) 338-1910.


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Nyx-Fleece Ram is one of most hilariously awesome cards we've seen from Wizards of the Coast's expert "Magic: The Gathering" expansion set "Journey Into Nyx." With draw-dropping art, a fantastic ability, and high toughness Nyx-Fleece Ram is cearly not a lamb meant for slaughter and will be blocking your opponent's threats all day long while you reap the rewards.
Nyx-Fleece Ram - 1W
Enchantment Creature - Sheep (Uncommon)
At the beginning of y our upkeep, you gain 1 life.
The gods are fascinated by innocence, perhaps because it's a quality they themselves lack.
Nyx-Fleece Ram comes down early, creating a roadblock for any rival's threats. As each turn passes, you'll gain an additional point of life. Nyx-Fleece Ram is stronger the sooner it enters the battlefield, potentially helping you gain five or more life over the course of a game.
Nyx-Fleece Ram can help you trigger Angelic Accord if you can manage to gain another three life, say from Path of Bravery or Trostani, Selesnya's Voice. Another card in Standard that interacts nicely with Nyx-Fleece Ram is Archangel of Thune, which will allow all your creatures to gain +1/+1 counters whenever you gain life. In time it'll transform your innocent sheep into a terrifying monster (provided you don't kill your adversary with your other threats first). Sanguine Bond will slowly drain your enemy's life total.
We're looking forward to drawing cards from Drogskol Reaver in commander, and perhaps flipping that Chalice of Life.
How will you use Nyx-Fleece Ram?
Keep up with the latest "Magic: The Gathering" info:
Subscribe for email alerts of new articles. You can also follow David on Twitter, Facebook, and Google+.
For more information about the game, visit www.MagicTheGathering.com.


text:
Brought to
you by
the New
York manufacturer of fine dance apparel for women and girls. Click
here to see a sample of our products and a list of web sites
for purchasing.
With Body Wrappers it's always performance
at its best.
Go back to Flash Reviews
Flash Document, 1-18:
Who Owns Martha Graham ?
Last Will and Testament
By Martha Graham
(As taken from public probate records)
(Editor's note: On Friday,
as reported in Flash News, 1-15: Protas Sues,
Ron Protas, executor and principal beneficiary of the Martha Graham
estate, sued the Martha Graham Center and School over the use of
Graham's name, and other claims. In the upcoming case in Federal
District Court, just who owns the rights to the works of Martha
Graham is likely to be the central question. What follows is Ms.
Graham's will, from public probate records. Certain words are unclear
in the copy provided to The Dance Insider by the Graham Center.
In such cases, we've written "unclear" in parenthesis.)
I, MARTHA GRAHAM, of
the County, City and State of New York, make, publish, and declare
this to be my last will and testament.
I hereby revoke all former
wills and codicils thereto made by me at any time.
I appoint my friend,
Ron Protas, to be executor thereof. If he shall not qualify or,
having qualified, shall cease to act as executor hereof, I appoint
my friend, Alex Racolin, to be executor hereof. I direct that no
executor appointed herein shall be required to give bond or other
security for the faithful performance of his duties in any jurisdiction.
All personal and household
effects, and other tangible personal property, held for purposes
of use or enjoyment as distinguished from business or investment
purposes, which I now own or may hereafter acquire, if owned by
me at the time of my death, I give and bequeath to my said friend,
Ron Protas, if he shall survive me. I request, but do not enjoin,
that he distribute certain of such items in accordance with my wishes
which are known to him.
The residue, remaining
after funeral and estate administration expenses and debts have
been paid and after the foregoing provisions hereof have been satisfied,
of all my property, real and personal, of every kind and description
and wherever situated, including all property over which I may have
power of appointment at the time of my death, all such powers being
hereby expressly exercised, and including all property not otherwise
effectively disposed of hereunder (said residue being hereinafter
referred to as my "residuary estate"), I give, (unclear), and bequeath
to my said friend, Ron Protas, if he shall survive me, or, if he
shall not survive me, to the Martha Graham Center of Contemporary
Dance, Inc.
In connection with any
rights or interests in any dance works, musical scores, scenery
sets, my personal papers, and the use of my name, which may pass
to my said friend Ron Protas under this Article IV, I request, but
do not enjoin, that he consult with my friends, Linda Hodes, Diane
Gray, Halston, Ted Michaelson, Alex Racolin and Lee Traub, regarding
the use of (unclear) rights or interests.
To provide for the execution
of the provisions of the will, the administration of my estate and
related matters:
(A) I give to my executor,
in affirmance and extension of the authority and power given to
executors by law, the authority and power (1) to retain and hold
my property, real and personal, or any part or parts thereof, in
the form in which the same may be invested at the time of my death,
and to sell the same at public or private sale, with or without
notice, for cash or credit or upon such terms and conditions as
my executor may deem wise, and in like manner to convey, exchange,
lease, mortgage, pledge or otherwise encumber the same; (2) to invest
funds and change investments without regard to whether such investments
or reinvestments are of the character prescribed or authorized by
law for the investment of trust funds; (3) to exercise or assert
in person or by proxy all rights, privileges and powers accruing
upon, appurtenant to, or available in connection with securities
included in my estate; and (4) to execute all such instruments and
to perform all such acts as shall be incidental to or necessary
or expedient in connection with the foregoing authority and power
or the proper execution of the provisions of this will or the proper
administration of my estate, all the authority and power given herein
to be exercised for such purposes as in the discretion of my executor
maybe deemed proper without the authorization or confirmation of
any court.
(B) I direct (1) that
the term "executor," as used herein, shall be deemed to mean the
executor or alternate executor appointed herein, whichever shall
be acting; (2) that a person shall be deemed not to have survived
me as such term is used herein where such person dies simultaneously
with me or dies under such circumstances that in the judgment of
my executor it cannot be determined with certainty whether such
person survived me or it would be impracticable to attempt to do
so; and (3) that my executor shall pay my death taxes without apportionment,
as if they were expenses of administering my estate, out of property
which, otherwise would be included in my residuary estate; and the
term "death taxes," as used herein, shall be understood to mean
all inheritance, transfer, succession and estate taxes levied by
reason of my death, regardless of whether such taxes are levied
on property passing or not passing under this will, and to include
all interest and penalties on such taxes.
have hereunto set my hand and seal at New York, this (handwriting
unclear) day of (handwriting unclear), 1989.
(The will is signed here,
in handwriting, "Martha Graham.")
The foregoing instrument
was subscribed by the above-named MARTHA GRAHAM, on the day and
year first above written, (unclear) our presence and was at the
same time published and declared (unclear) her in the presence of
each of us to be her last will and testament, and thereupon we,
at her request, and in her presence and in the presence of each
other, did subscribe our names as attesting witnesses.
(The will is signed,
here, in handwriting, with three names, the only one of which is
legible in the copy provided us is that of Linda Hodes.)
back to Flash Reviews
Go Home


text:
Fiji is one of the most popular tropical destinations in the South Pacific and you can find many package deals that can make your trip one of the best but also one that fits into your budget.
There are a number of different deals and packages on offer that can range from all inclusive deals, last minute, luxury, honeymoon and wedding packages.
Package Deals in the Fiji Islands


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I was in the process checking some of my existing plugins for any unsafe filesystem accesses, when I ran across WP_Image_Editor's
save function, which calls
_save, which finally calls
make_image (below). WP_Image_Editor was released in
WP 3.5, while the
Filesystem API has been around since
WP 2.6, so I would presume that the reasoning is related to the specifics of the use-case rather than just not being changed to meet new standards.
protected function make_image( $filename, $function, $arguments ) {
if ( $stream = wp_is_stream( $filename ) ) {
} else {
// The directory containing the original file may no longer exist when using a replication plugin.
wp_mkdir_p( dirname( $filename ) );
$result = call_user_func_array( $function, $arguments );
if ( $result && $stream ) {
$contents = ob_get_contents();
$fp = fopen( $filename, 'w' );
if ( ! $fp )
return false;
fwrite( $fp, $contents );
fclose( $fp );
if ( $stream ) {
return $result;
My question is, what are the reasons for this? According to Otto, directly accessing the filesystem is evil, so what are the exceptions that make it alright in this instance? I want my plugins to behave in the best way possible, but this makes best practices a little difficult to discern.


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In the NHL – and sometimes in business - it can take a number of years to build a contending team.
The key is ownership and understanding what you need to create a business that will sustain long term competitiveness. You have to avoid "quick fixes." Draft and stock pile good, young talent, making sure to turn over their player roster in the years ahead.
In my fifth season with the Rangers, we won the Stanley Cup for the first time in 54 years. We were only able to do this because of the collective work of myself and my recent predecessors who had accumulated some good young talent. We were able to parlay some of these assets into more seasoned players who were better in playoff wars.
When you are looking for the right players, their ability to contribute to the future success of the team is key.
"Neil Smith was able to do what no other general manager could in 54 years for the New York Rangers-win the Stanley Cup! It was Neil's bold approach to changing the culture that allowed the team to galvanize into champions."


text:
- Final Fantasy XII - The Zodiac Age
Announcement Trailer
- Hard Reset Redux
Gameplay Video
- Yooka-Laylee
E3 Trailer
- Horizon Zero Dawn
Aloy\'s Journey Trailer
- Agents of Mayhem
Announcement Trailer
- LEGO Star Wars: The Force Awakens
BB-8 Gameplay Trailer
- Dangerous Golf
Launch Trailer
Street Fighter X Tekken Cheats
|ON OTHER PLATFORMS: Xbox360, Playstation 3, PS Vita
publisher: Capcom Entertainment
developer: Bandai Namco
genre: Miscellaneous
|ESRB rating: T
release date: May 11, 12
|» All About Street Fighter X Tekken on ActionTrip
There are 52 Bronze Trophies, 6 Silver Trophies, 1 Gold Trophy, and 1 Platinum Trophy.
A Glimmering Light (Bronze): Activate your Assist Gems 30 times.
A Perfect Victory! (Bronze): Win a round without getting hit 30 times.
A Splendid Conclusion (Bronze): Finish a round with a Super Art 30 times.
A Very Special Gift (Bronze): Connect with 50 Special Moves.
After The Dust Has Settled (Bronze): Clear Arcade mode on Medium difficulty or higher.
All Star (Bronze): Use all characters.
All Too Easy (Bronze): Win by K.O. using Battle Tap.
An Unknown Power (Bronze): Activate Pandora 50 times.
Any Time, Any Place! (Bronze): Use Arcade Fight Request 10 times.
Anything Goes (Bronze): Activate Cross Assault 50 times.
Doused In My Color! (Bronze): Customize a character's color.
Evangelist Of The "X" (Bronze): Have your replay downloaded 3 times in My Channel's Broadcast Mode.
Forge Your Own Path (Bronze): Win 10 matches online.
Fruits of Labor (Bronze): Go into Training mode 3 times.
Head Of The Dojo (Bronze): Create a lobby in Endless Battle.
Here's My Shoutout (Bronze): Customize your player comment.
I'm Just Getting Started! (Bronze): Swap teams in Arcade Mode.
It's Just For Research! (Bronze): Access the Store.
Just The Beginning (Bronze): Clear one trial in Trial mode.
Learn The Fundamentals (Bronze): Win 5 matches online.
Let's Heat Things Up! (Bronze): Activate your Boost Gems 30 times.
Love Is Blind (Bronze): Use a character in battle over 30 times.
Maelstrom Of Combos (Bronze): Connect with 30 Quick Combos.
Magnanimity (Bronze): Give 5 character color gifts.
Maturity Through Discipline (Bronze): Clear all of the lessons in the Tutorial.
Mission Specialist (Bronze): Clear all of the missions in Mission mode.
My Big First Step (Bronze): Clear one lesson in the Tutorial.
Observer (Bronze): View 3 replays in the Replay Channel.
On the Cutting Edge (Bronze): Fight using Casual Style.
One Down! (Bronze): Win in a Ranked Match.
Photo Op (Bronze): Take a photo in the AR Gallery.
Power Consumes All (Bronze): Finish a round with Pandora 30 times.
Proof Of Your Victory (Silver): Get to C rank for the first time in Ranked Match.
Signs of Friendship (Bronze): Fight in Ad Hoc Mode.
Stories to Tell (Silver): Unlock every item in the Graphic Gallery.
Sturm und Drang (Bronze): Finish a round with Cross Assault 30 times.
Supersonic (Bronze): Play the Sound Gallery 3 times.
Ten Down... (Bronze): Win 10 consecutive Burst Kumite battles.
The Battle Never Ends (Bronze): Win a match in Endless Battle.
The Chosen Path (Silver): Win 30 consecutive Burst Kumite battles.
The Cross Revolution (Bronze): Finish a round with a Cross Art 30 times.
The Crossroads of Tragedy (Bronze): Fight 30 matches online.
The Endless Road (Bronze): Fight 100 matches online.
The Excellence of Execution (Bronze): Clear 100 trials in Trial mode.
The First Mission (Bronze): Clear one mission in Mission mode.
The Harsh Road (Bronze): Fight 50 matches online.
The Root Of Chaos (Silver): Defeat all of the bosses in Arcade mode on the hardest difficulty.
The Stones Guide Me (Bronze): Customize a Gem Unit.
The Warrior's Road (Bronze): Fight 10 matches online.
This Is How I Roll (Bronze): Customize your player Title.
Time For Some Fireworks! (Bronze): Connect with 50 Launchers.
Title Idol (Silver): Obtain 300 Titles.
To the Victor Go the Spoils (Bronze): Obtain a K.O. Monument.
To The Victor... (Silver): Raise your battle class rank for the first time in Ranked Match.
Trail Of Ruined Dreams (Bronze): Defeat 5 rival teams in Arcade mode on Medium difficulty or higher.
Transcend All You Know (Bronze): Win 50 matches online.
Trial Expert (Bronze): Clear ten trials in Trial mode.
Two Minds, Fighting As One (Bronze): Connect with 50 Cross Arts.
Your Legend Will Never Die (Gold): Win 100 matches online.
Zenith (Platinum): Unlock all Trophies.
Pandora Mode in Burst Kumite
After gettin 10 consecutive wins, you can toggle Pandora mode on or off. Turning Pandora Mode on puts both team members in Pandora Mode the entire duration of the match, giving them both increased damage output and a Cross Gauge that replenishes itself in less than three seconds
Unlock Pandora Mode in Burst Kumite: Win 10 consecutive matches
46 or 151
|Click here for more cheat codes