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A friend just picked up a Hy Hunter 44 Mag. Single Action revolver w/ 6" barrel in a trade.I was wondering if anyone here had a Blue Book of Gun Values & could pass on what its worth, to me.Its nothing fancy, Imported from West Germany to Hy Hunter Firearms Co. Hollywood Ca. Circa 1950's or so.I know its propably not worth much, but for the right price I might make it a carry pistol when I'm up in the hills.Thanks Lee
Pistol Worth??
Started by BPS , Jul 18 2010 08:52 AM
4 replies to this topic
Posted 18 July 2010 - 08:52 AM
Posted 18 July 2010 - 09:08 AM
Not sure about prices, but here is some info;Great Western
Posted 18 July 2010 - 09:38 AM
Wow very informative link, Thanks Lee
Posted 18 July 2010 - 09:53 AM
You're Welcome.
Posted 18 July 2010 - 10:05 AM
I asked my Cowboy match guy who has about 25 wheel guns and he says they are worth more than the bluebook indicates which is low (like $165) but he has seen them sell for twice that in good condition and the right model.
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By JOHN McCALLUMEditor
Write to the Point
March 28, 2013 | Vol. 116 -- No. 49
This is an interesting week as it marks the juxtaposition of two religious observances important to two different faiths, yet very intertwined.
Tuesday, March 26, marked the beginning of Passover for members of the Jewish community, an important holiday, if you can call it a holiday that runs through April 2. The same goes with the other holiday, Easter, which for many Christians begins today with Maundy Thursday and culminates Sunday with Easter.
I raise the issue of calling these observances holidays because, unlike other holidays, most people don't receive time off from work and most b...
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Harmless Harvest
by Harmless Harvest
Product Type
Juice: Coconut Water and Juice
8 oz PET
Nutritional Info
Calories 45 Calories from fat 0 Total Fat 0 Saturated Fat 0g Trans Fat 0g Cholesterol 0mg Sodium 247mg Potassium 588mg Total Carb 9g Dietary Fiber 3g Sugars 6g Protein 2g Vitamin A 0% Vitamin C 10% Magnesium 17% Iron 4% Phosphorus 5% Calcium 6%
100% organic coconut water
Review: 100% Raw Coconut Water
Posted: Jul 26, 2011 at 12:00 AM (Last Updated: Jul 26, 2011 at 2:47 PM)Following up on a USDA Organic coconut water that was briefly launched last fall, Harmless Harvest's newest effort, 100% Raw Coconut Water, is unlike any other packaged coconut water that we've had to date. While there are subtle differences between every coconut water brand out there, this product has a noticeably fresher and greener flavor. In fact, Harmless Harvest 100% Raw Coconut Water is the closest thing we've had to coconut water that's fresh from a coconut. To achieve this, Harmless Harvest uses a "never heated" process that uses thousands of pounds of pressure to protect the product from bacteria. However, the resulting product is perishable, requiring refrigeration at all times. Unfortunately, this limits accessibility to the product, especially since competing brands have increasingly prominent displays at retail. Still, it's a product that's very much worth seeking out – and we're sure that they will be able to find a loyal niche of consumers with the high quality flavor that this drink has. On the packaging front, the 8 oz. bottle is extremely small to the point where it can be consumed in a matter of seconds. We're still big fans of their branding and design, which, with its earthy illustrated artwork, feels like the perfect complement to what's inside the bottle. Overall, the small package size leaves us hoping that they'll come out with other formats, but we wouldn't change a thing with the look and flavor of this stellar product.


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by Cristi on September 11, 2013. This post may contain affiliate links.
POSTED IN: Kroger, Kroger Weekly Ad, Uncategorized
As of July 31st Krogers Central Region which includes our Troy and Warrenton Missouri stores will no longer double coupons. In lieu of double coupons Kroger is offering everyday lower prices. Krogers has stated that they will also be offer better value digital coupons as well. The Kroger matchups will no longer include double coupons to reflect the new policy changes. To help make your dollar Stretch take advantage of the Saving Star Program and download all possible coupons that you may use HERE.
Kroger Bread $.88
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Jogging on the Reedley Rail Trail Community Parkway provides fun and fitness for free. One can reach this trail by parking at Reedley College by Manning Avenue. However if you park here you may have to pay for a permit to park here. Another option to to park at the shopping mall across from the campus on Manning Avenue. The walk to the trail head is a bit longer. However the parking is free. The trail can all be accessed by parking at City Hall or County Courthouse or Reedley High School and entering it mid way. The jogging and running trail begins at the Reedley Colleg however it continues through and past City Hall and the Courthouse. It then goes through downtown areas. You can the go hiking, jogging, or running pas Reedley High School and many elementary schools. There are also several park and ride lots that you pass as you go jogging or running. It ends at the Kings River. If you do park near the Reedley College end consider bringing a picnic lunch. After walking, jogging, or running you can sit in the gazebo by the river and have a wonderful lunch gazing at the Kings River.
The hiking, jogging, and walking trail is used by cyclists, inline skaters, and walkers so be careful as you are running to be nice to others. Additionally expect to do the trail back and forth a few times if you want an extra long hiking, jogging, or running experience. The trail is only 2.6 miles each way. It is next to the railroad tracks so each to follow. However it does pass some very busy streets at times so watch out for air quality. We do not want you to try to be healthy and do something that defeats the purpose.


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Fabio Borini's goal for Italy U21s proved decisive as the young Italians clinched a 1-0 friendly victory over Germany on Wednesday night.
The 21-year-old was in the right place at the right time as he arrived to tap home Lorenzo Insigne's pass on 59 minutes.
Elsewhere, Steven Gerrard and Glen Johnson played their part as England claimed a memorable 2-1 victory over Brazil at Wembley.
Gerrard was presented with a golden commemorative cap by Peter Shilton prior to kick-off to mark his 100 appearances for England.
However, when the match got underway, it was Brazil who seized the initiative and they went close on 19 minutes by forcing Joe Hart into a superb double-save to twice deny Ronaldinho.
Roy Hodgson's men took the lead six minutes later. Wayne Rooney pounced on a loose ball to slot through a cluster of yellow shirts after Theo Walcott went close for the Three Lions.
They were pegged back just after the interval when Gary Cahill's error allowed Fred to collect the ball and arrow it beyond Hart from the edge of the box.
Frank Lampard restored the one-goal advantage on the hour mark by hammering a Rooney lay-off past Julio Cesar and into the net via the inside of the 'keeper's left post.
Luis Suarez played the full 90 minutes for Uruguay as they went down 3-1 to the reigning World Cup and European champions Spain.
Suarez partnered the deadly Edinson Cavani up front; however, Uruguay found themselves behind when 'keeper Fernando Muslera spilled Cesc Fabregas' speculative 35-yard effort into the net on 16 minutes.
The Uruguayans pulled level just after the half-hour mark when Martin Caceres fed Cristian Rodriguez, who spun away from Carles Puyol and tucked the ball beyond Victor Valdes to equalise.
Barcelona's Pedro took matters into his own hands in the second half, firing twice to hand the Spaniards a two-goal advantage and ultimately seal victory out in Qatar.
Daniel Agger played the entire game for Denmark as they lost 3-0 to FYR Macedonia in Skopje. The hosts raced into the lead courtesy of an eighth-minute strike from Napoli striker Goran Pandev.
Agim Ibraimi doubled Macedonia's advantage on 17 minutes before Nikolce Noveski put the finishing touches to a commanding display by adding a third just after the half-hour mark.
Joe Allen was back at Liberty Stadium for the second time since swapping Swansea for Liverpool last summer.
The midfielder made an immediate impact, providing the ball for Gareth Bale to fire the Welsh ahead against Austria after 21 minutes of play.
Bale then turned provider as he crossed for Sam Vokes to nod home Wales' second of the night. Marc Janko pulled a goal back for the visitors late in the game but the home side held firm for a 2-1 win.
There was late drama for Martin Skrtel and Slovakia when Richard Lašík netted an 88th-minute equaliser against Belgium to seemingly clinch a draw in Brugge.
However, Dries Mertens fired an even later winner for the Belgians, who ran-out 2-1 winners.
Meanwhile, Liverpool's young stopper Danny Ward made his debut for Wales U21s and kept a cleansheet as his side comfortably beat Iceland 3-0.
Tagged: international , round-up


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Methylated cobrox
One of my all-time favorite TV shows is The Man From U.N.C.L.E. from the mid-1960s. I didn't watch TV in the 60s. I discovered The Man From U.N.C.L.E. many years later and got hooked on it only within the last year when I learned that the entire show was available on Netflix. Despite its primitive special effects, outdated gadgetry and the often silly plots, I get a kick out of watching the U.N.C.L.E. agents Napoleon Solo and Illya Kuryakin carry on their perennial fight against the bad guys of T.H.R.U.S.H.
In the episode I watched last night, The girls of Nazarone affair, a flower vendor is killed and Illya, posing as a doctor, examines him and determines that a poison had been delivered to the victim via the pin on a corsage. Illya later informs Napoleon that the poison was "methylated cobrox". Subsequently, Napoleon and Illya find pins, also dipped in methylated cobrox, sticking out of their pillows in their hotel room.
There is no such chemical as methylated cobrox or even as cobrox as far as I can tell. In fact, a Google search for "methylated cobrox" returned no hits. This post has apparently become the only page on the Internet that now mentions methylated cobrox.
Was the poison needed in the show so unrealistic that it needed to be invented with a new, made-up name? Or was it considered unethical to name a real poison in a TV show back in the 1960s? People, on the other hand, smoked incessantly on TV and in the movies. It probably didn't dawn on the makers of TV shows that cigarettes were killing innumerably more people in real life than could the imaginary methylated cobrox ever do in movies.


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Artist: Emery
Album: The Weak's End
Genre: Rock
You have always seen
The best parts of me
With my uncovered eyes
Loose from lenses absorbing light
Your hand is wrapped in mine
The sun set for the last time
Carpet stains from coffee cups
Thrown to stop from hurting so much
Paralyzed, I thought I'd fail you somehow
And let you down
But you saved me from death
Awakened the life for the first time
Joining as voices sing together
The same song
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Liberty, Equality, Fraternity . . . And Criminal Fines for Veils
To people weaned on the U.S. Constitution, France's new law banning wearing veils in public seems nothing short of shocking.
(Were Congress or a state legislature to pass such a law, it'd be struck down as unconstitutional quicker than you can say "Free Exercise Clause.)
In any event, France hasn't yet adopted our First Amendment as part of its own legal system, so it's apparently free to pass such an edict.
The ban went into effect on Monday. Within a few hours, police detained two women who had covered their faces at an impromptu demonstration outside Notre Dame Cathedral. Click here for the LAT article; here for the BBC article. Police said the women were taken into custody not because of their veils, but because the protest was unauthorized and they had refused to leave when asked.
The measure makes no specific mention of Islam, but President Nicolas Sarkozy's government promoted the law as a means of "protecting" women from being forced to wear full-face veils.
Those who defy the ban face a $216 fine and attendance at a "citizenship course." A person who forces a woman to cover up through "abuse of authority or power" can be fined up to $43,000 — double if the covered female is a minor — and jailed for as long as a year.
Kenza Drider, one of the veiled women detained Monday, had traveled from from Avignon to attend the demonstration. "I am carrying out my right as a French citizen," she said before being taken into custody. "I am not committing any crime. If anything, it is this law that is criminal."
"This whole law makes France look ridiculous. I never thought to see the day when France, my France, the country I was born in and I love, the country of liberty, equality, fraternity, would do something that so obviously violates people's freedom."


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Bridal Wear
Bridal Sarees
Backed by a diligent team of artisans and craftsmen, we are engaged in offering our clients with Bridal Sarees. These are known for glorifying the beauty of the bride on the auspicious day of the wedding. Offered in maroon color, these faux georgette sarees are dexterously embroidered and adorned with resham, zari and sequins work. We offer these sarees in a variety of color combinations, patterns in the brocade blouse and patch patti borders.
Bridal Suits
Our clients are provided with Bridal Suites that are high in demand among our fashion conscious clients. Manufactured using optimal quality material, these are appreciated for their features like appealing colors and intricate embroidery. Designed to excellence, these can be designed as per the specifications detailed by our clients.
|Product Code:
Bridal Lehengas
Our forte lies in manufacturing and exporting of Bridal Lehengas that are made using optimum quality fabric. The lehengas offered by us are considered as one of the best options to be worn on propitious occasion like marriage. We offer these in a variety of patterns and these are appreciated for rich fabrics, colors, designs and embroideries.
Khara Dupatta
Our clients can avail from us Khara Dupatta (upright stole) that is designed to perfection under the expert supervision of our professionals. The dupatta is an intricate wedding ensemble that comprises kurta (tunic), chooridaar (extra-long slim pants that gather at the ankles) and a 6-yard dupatta (stole or veil). Moreover, the dupatta offered by us are traditionally worn by Hyderabadi Muslim brides.
Designer Sarees
we are known in the industry to offer designer sarees that are offered in varied styles and vivacious color combinations. Ideal to be worn on wedding and other festive occasions, these are appreciated for their exclusive designs and optimal quality. Moreover, these are designed in various floral, geometric and abstract patterns.
To,Arzu Ethnic Ensembles


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It's about time folks start taking notice of another former Wildcat who is tearing the cover off the ball this season.
Sawyer Carroll, a former All-American at UK, has picked a good time of the year to get hot. The native Oklahoman has been a staple in the middle of the lineup for the San Diego Padres' Class AA San Antonio Missions, who are currently 89-44 and, according to their winning percentage, the best full-season team in the minor leagues to this point.
Carroll has displayed power- 17 home runs so far in 2011- and a strong arm from right field (check out this great video clip), and is hitting .351 in his last ten games, with a pair of homers, four doubles, and ten runs scored.
Carroll was a Mid-Season Texas League All-Star, and was named Texas League Player of the Week in June, adding two more accolades to an already impressive professional career. The 2009 San Diego Padres Minor League Hitter of the Year was also a Midwest League All-Star, the Midwest League All Star game's Top Star, and a Northwest League Post-Season All-Star.
Carroll left Kentucky after two years as the all-time record holder in batting average, hitting .386 (173-for-448) in 117 career games, adding 45 doubles, five triples, 22 homers and 139 RBI, posting a 83-58 walk-strikeout ratio and stealing 16-of-19 bases. Carroll's .483 career on-base percentage checks in second-best in the 105-year history of UK baseball. During his historic 2008 season for UK, Carroll batted .419 (98-for-234) with 22 doubles, three triples, 19 homers and a school-record 83 RBI, stealing 12-of-12 bases and drawing 44 walks. Following the 2008 season, Carroll was named a consensus All-American (via ukathletics.com).
I never got the pleasure of being his teammate, but I've gotten to know Saw over the past few off seasons. He's a great dude and has worked himself into the long-term picture for the Padres, who are 60-74 in 2011 and in last place in the NL West.
It will be interesting to see what San Diego does with their September call-ups, but you'd have to think that the Padres consider a promotion, and I'm not the only one that thinks so. Check out this interestingly-titled post from rjsfro.com.
We are UK.


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Thailand's military: perpetually political, forever factionalized, again ascendant
Guest Author: New Mandala
The Thai armed forces have been major players in Thai politics since the 1932 coup which ended the absolute monarchy.
During the 1990s, some suggested that Thai soldiers were increasingly being by-passed by new societal forces, thus making the armed forces less relevant political players.
This study contends that during the 1990s the Thai military was not depoliticized. It has been argued that a 're-politicization' of the Thai military occurred with the 2001 election of the Thaksin Shinawatra government. Thaksin brought a large team of persons with senior military backgrounds to office. By placing responsibility for military re-politicization at the door of Thaksin, some people indirectly fault him for the 2006 coup—in which the armed forces once again assumed direct political power.
In 2008, the military's successes in helping oust Thaksin's elected nominee government from office, and then building an anti-Thaksin civilian government, have resurrected its clout. However, these events have triggered broad repercussions for Thailand's entire process of democratisation. That process had seen the country follow a trajectory toward greater pluralism and political space since 1992. The 2006 coup obliterated much of the democratic progress. The election of December 2007 seemed to breathe new life into pluralism, but the new democratic roots have been proven to be shallow. Only last years Thailand again saw the military willing and able to involve itself in unconventional, indirect political intrusions—to the point of removing two Thaksin-aligned governments.
In late August 2009, new rumors emerged of a possible military coup against the government of Prime Minister Abhisit Vejjajiva. This gossip coincided with an attempt by Red-Shirt leaders to petition Thailand's king to pardon Thaksin Shinawatra. It was a tense period during which violence might provide the necessary springboard for military intervention. There has been no coup, but such rumours underline the continuing popular perception of an extreme lack of civilian control over Thailand's military. Discussion of these matters is important in a country where the army has proved that it will continue to exercise its role as a political arbiter.
This is an abstract of an article by Paul Chambers that appeared here on New Mandala.
Post a comment
East Asia Forum welcomes comments, both for adding depth to analysis and for bringing up important new issues. Original comments adding insight and contributing to analysis are especially encouraged.
The editors retain the right to refuse and edit comments at any time.


text: Just a small picture I started drawing on paper as I was listening to Just A Kiss by Lady Antebellum then I decided to make it into my werewolf character, Lyall and her boyfriend Rye kissing. I'd really love your feedback on this. I spent time... 14 hours to be exact to draw this. Not that I minded it was alot of fun! I hope you like this! Also the backround I tried to make it go with the chorus of the song. Chorus to the song Just a kiss on your lips in the moonlight Just a touch of the fire burning so bright No, I don't wanna mess this thing up No, I don't wanna push too far Just a shot in the dark that you just might Be the one I've been waiting for my whole life So baby, I'm alright, with just a kiss goodnight So now you have just a kiss on your lips in the moonlight and a touch of the fire burning so bright. ~Twi~


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Caney finally got everything cleared so we could meet for services. Seemed almost like a family reunion and we got fed spiritually once again. The choir sang an old favorite hymn, "Blessed Assurance." Bro. Ed's message was from Philippians 1:20-24. "Need not be ashamed to be a Christian." Are we losing why we go to church? Are the social events taking over. Jesus is the way. We seem to be getting out of fellowship in the church. Are we sharing our faith and telling all what Christ has done for us. We should live our life so Christ will be proud.
Editor's note: The News-Herald reports all misdemeanors, felonies and small claims judgments in district court, except for juvenile court proceedings, which are confidential; however, traffic offenses by juveniles are reported because they are public record. All civil suits in circuit court are reported. Claims made in a lawsuit present only one side of a case. Charges or citations reported to the News-Herald do not imply guilt. That is determined by the court. Information on this page is public record. Names will not be withheld by request.
Justin L. Combs, 1988, second-degree complicity burglary, complicity receiving stolen property under $10,000, adopted plea agreement.
Echo D. Cummins, 1989, first-degree possession of heroin, drug paraphernalia, pleaded guilty, diversion.
Lonnie R. Kemper, 1970, first-degree sodomy, second-degree sodomy, third-degree sodomy, first-degree sexual abuse, jury trial set for Feb. 16.
Roseann M. Mitchell, 1972, flagrant non-support, continued to Feb. 8.
Thomas Y. Nakajima, 1974, continued to Feb. 8.
Chad Nordman, 1984, failed to pay fines and costs, owes $730.
As winter-weather warnings were being forecast for Owen County Monday, the Owen County road crew began preparing for another blast of snowy conditions.
Monday morning, a winter weather advisory was issued for Owen County. As forecasted, the snow began Tuesday morning and was expected to continue through the early hours of today.
Snow accumulations of two to four inches were expected by early today.
Despite a push from Owenton Mayor Doug West for a fresh face in the city attorney's position, a motion was not made in favor of local attorney Mitzy Evans.
On Jan. 3, West told the News-Herald that he had chosen to not re-appoint Owenton's longtime city attorney, Mark Cobb, saying he would recommend Evans to the position.
The Owenton City Council must approve any nomination before the nominee can assume the role.
The council met Jan. 4, where no motion to appoint Evans was made.
Friday, Owen County High School students named their 2010-11 basketball homecoming king, queen and court. Pictured are (from left) Malachi Mefford, Abigail Lawson, homecoming prince Sawyer Williams, homecoming princess Ashley Smith, homecoming queen Danielle Hoop, homecoming king Brian Widner, Isaac Wash and Rayna Taylor.
Local law enforcement vehicles lined West Seminary and North Main Streets Monday in honor of a former Owen County Sheriff's Office dispatcher.
Marvin C. Ogden, a lifelong resident of Owen County, died Jan. 6.
Ogden was born in 1918 and was a member of Owenton First Baptist Church where he served as a former deacon.
A 75-year member of the local Oddfellows Lodge No. 213, Ogden was the longest living member in Kentucky.
Ogden also served in World War II, where he earned a Purple Heart.
Weather forces changes at Adult Learning Center
Because of snow days last week, the Owen County Adult Learning Center was unable to offer the previously scheduled official GED practice test.
The test will be offered again Jan. 31 and Feb. 2.
Interested parties should contact the Adult Learning Center at 484-0405 by Jan. 27.
The Jan. 27 GED test has been rescheduled for Feb. 17.
For more information contact the Adult Learning Center at 484-0405.
Gaming Day returns to the library Thursday
The law says you can't yell "fire" in a crowded movie theater.
But can you nudge the guy next to you and say "psst... that guy up front looks like he wants to start a fire,"?
This weekend, the country was once again shocked by violence when six people including a member of the U.S. House of Representatives, a federal judge and a 9-year-old girl were shot by a lone madman in Arizona.
The question that leaps to most people's mind is why.
Although it seems unbelievable, 50 years have passed since the 1960s when a decade of historic events occurred — both in Owen County and across the country — events that affected the lives of all of us, and in doing so, presented opportunities to preserve our history.
Copyright © 2016
The Owenton News-Herald is your source for local news, sports, events and information in Owen County and Owenton, KY, and the surrounding area.


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"Fire Idzik". "Idzik is clueless." "Do the New York Jets have any type of plan?" Yes, these are some of the messages that are being posted on New York Jet fan forums after only one week of NFL free agency. Is the hysteria that is running through some parts of Jets nation warranted? I don't believe so, and there are several reasons why.
The New York Jets entered the free agency signing period armed with a significant amount of cap space. The instant speculation, which was fueled by many members of the media, was that Gang Green would be very aggressive and would sign a couple of the high-profile players that were available. Well after listening to Jets general manager John Idzik, it was quite obvious that was not the approach the front office was going to take. Idzik's philosophy is to build through the draft and to use free agency to fill some holes. The Jets gm will set values to each player and position and will not spend wildly just because there is cap space available. Idzik's plan is focused on sustainable success, not short-term gratification.
With a pragmatic philosophy in place the Jets did go out and sign one of the best wide receivers available in Eric Decker. The former Bronco will be a tremendous asset to the Jets offense with his size and athletic ability. Gang Green also replaced right tackle Austin Howard with Breno Giacomini while re-signing Leger Douzable, Calvin Pace, Jeff Cumberland, Ellis Lankster, Nick Folk, and Darrin Walls. These signings will not be considered high-profile by many, but they give the Jets much-needed depth and continuity.
Going forward the Jets will continue to add pieces to their puzzle, but at the right price. Lets not forget that this is only March and hundreds of personnel moves will occur between now and the end of training camp. There are salary cap casualties, trade opportunities, not to mention some quality free agents still available. Also the draft, Idzik's lifeline, features one of the deepest classes in recent years.
It is time for Jets fans to take a deep breath and to look at the big picture. History dictates that the teams that win the headlines in March normally don't hold the trophy in February. John Idzik is taking a different approach to rebuilding his team and it is going to take some getting used to. Lets see what this team looks like at the end of training camp before making any rush judgements on John Idzik. I have a feeling fans of Gang Green are really going to like what they see on the field come September.


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The new drag queen cast of "RuPaul's Drag Race" season 6 were released on Dec. 9, 2013. "RuPaul's Drag Race" season 6 starts in February of 2013. This season RuPaul will introduce 14 new drag queens vying to become the next drag superstar. Meet the complete cast of "RuPaul's Drag Race" season 6 below.
Adore Delano is a 23-year-old from Azusa, Calif. His real name is Danny Noriega and was a finalist on American Idol season 7.
April Carrion is a 23-year-old from Puerto Rico. April has never done drag outside of Puerto Rico.
Ben De La Creme is a 31-year-old from Seattle, Wash. She is friends with Jinkx Monsoon, the winner of season 5. Ben has a similar style and sense of humor to Jinx.
Bianca Del Rio is a 37-year-old from New York City. She is a very funny and quick-witted queen.
Courtney Act is a 31-year-old from Sydney Australia. She is a stunning blonde that looks so much like a woman that you will do a double take.
Miss Darienne Lake is a 41-year-old from Rochester, NY. She is named after an amusement park. Darienne is a large queen who happens to be Pandora Boxx's drag mother.
Gia Gunn is a 22-year-old from Chicago, Ill. Gia takes her last name from Project Runway's Tim Gunn.
Joslyn Fox is a 26-year-old from Worcester, Mass. Joslyn has been performing in drag for six years. She is friends with Jujubee.
Kelly Mantle is a 37-year-old from Los Angeles. Kelly Mantle is her real name, she is a singer and comedian.
Laganja Estranja is a 24-year-old from Los Angeles. Alyssa Edwards is her drag mother. Her style is classy, ghetto-fabulous.
Magnolia Crawford is a 27-year-old from Seattle, Wash. She considers herself to be a campy, thrift shop queen.
Milk is a 25-year-old from New York City. Says her inspiration is The Muppets. Milk is very sarcastic but funny.
Trinity K. Bonet is a 22-year-old from Atlanta, Georgia. Trinity was born in Jacksonville, Fla. Her mother, while in the hospital requested she go on "RuPaul's Drag Race"
Vivacious is a 40-year-old from New York City originally from Jamaica. Her style is old school club kid style drag.
"RuPaul's Drag Race" season 6 will air on Mondays beginning in February on LOGO. Check your local listings for showtimes in Jacksonville.
Suggested Links
- American Idol 7 finalist Danny Noriega auditions for RuPaul's Drag Race 5
- 'The X Factor' USA: Alex & Sierra reach #1 on iTunes with 'Say Something'
- 'Survivor: Blood vs. Water' star Tina Wesson's only son died in a car accident
- Crystal Bowersox from 'American Idol' is 'Coming Out For Christmas' as bisexual
- 'RuPaul's Drag Race' season 5 cast: Meet the 14 new drag queens tonight (Photos)


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|Registration (best rate by 1/27)
|Call for Papers (deadline 9/16)
| Conference questions?
Workshop Registration (schedule & descriptions below)
You must register for the conference in order to register for a workshop. Pre-registration for workshops is strongly encouraged, as space is limited and workshops will be filled on a first-come, first-served basis. Please register online for the conference and workshops.
Pre-conference insurance workshop, Wed. 2/15, 9am-4pm. CalABA's Public Policy Committee will host an all-day, pre-conference workshop on insurance coverage for autism on Wed. 2/15. Space will be limited and this event is expected to sell out quickly. See below for more information on this workshop.
For more Public Policy Track events, search for "Public Policy Track" on our Program & Search page.
NOTE: Workshops will be the only sessions available on Wed. 2/15 and Sat. 2/18. All other presentation types (addresses, symposia, panels) will be scheduled for the concurrent sessions on Thu. 2/16 and Fri. 2/17.
Continuing Education (CEUs):
Program Area:
Workshop Descriptions and Schedule (subject to change check this site periodically for updates)
Wed., Feb. 15, 2012 9:00 a.m. 4:00 p.m.
(see other workshops available Sat. 9am - 12pm, Sat. 9am - 4pm and Sat. 1pm - 4pm) (top)
Workshop # 1 (PEL - Intro)
Public Policy Track
Health Plan Coverage of ABA Tx of Autism in California:
What It Means and How To Do It
This is a "how to do it" workshop for administrators of ABA agencies and BCBAs who are currently billing health plans or are interested in becoming a credentialed healthcare provider. Participants will learn how to become a credentialed healthcare provider and be recognized by insurance companies. Attendees of this workshop will learn the specifics required to access such coverage on behalf of clients and their families including how to use billing codes and modifiers, how to submit claims, and how to make appeals to insurance companies when denied. Some of the associated potential changes in funding and provider structuring will be discussed. Presenters will discuss ethical issues related to insurance coverage and the right to effective treatment. An expert panel will also be a part of this workshop in order to allow participants to ask questions about working with insurance systems in California and beyond. Implications for the practice of ABA brought about by health plan coverage, including ethical and practical considerations, will be discussed.
Participants in this workshop will:
Sat., Feb. 18, 2012 9:00 a.m. 12:00 p.m.
(see other workshops available Wed. 9am - 4pm, Sat. 9am - 4pm and Sat. 1pm - 4pm) (top)
Workshop # 2 (PEL - Adv)
Ethical Considerations for Clinical Applied Behavior Analysts
This workshop is designed to advance the understanding of ethical standards of the behavior analyst. We will review the ethical guidelines of the BACB and discuss scenarios related to common ethical dilemmas in a clinical practice. We will provide tools to develop supervisory systems for monitoring and maintaining ethical conduct. We will address training direct-line staff on maintaining the ethical standards of your organization. Finally we will cover the limits of scope of practice as well as address requests to integrate non-empirically based practices and procedures.
Participants will learn to develop supervisory systems for maintaining ethical conduct in an organization, and to train direct-line staff on how to engage in appropriate ethical behavior. The participants will also learn how to recognize advanced ethical dilemmas and how to manage them.
Workshop # 3 (ED, AUT - Intermed)
Using What Works in Education: Applying Effective Behavioral Education Practices to Learners in SPED/RED
Effective instructional practices grounded in the principles and practices of Behavior Analysis have significant evidence supporting their effectiveness for a variety of learners in different settings across subjects. Many Behavior Analysts are familiar with behavioral education models but fail to utilize them in the daily design and practice of behavior analysis. This workshop is designed to take practitioners from knowledge of these concepts to application in individual and group learning environments for learners with special needs, including those with Autism, through typical learners in regular education settings. In particular, the Personalized System of Instruction (PSI), Precision Teaching (PT) including use of the Standard Celeration Chart, and Classwide Peer Tutoring (CWPT) will be described as systems, integrated into program design, used, and evaluated by participants.
Participants in this workshop will learn to:
Workshop # 4 - Invited Speaker
(AUT Intermed)
Teaching Children with Autism Using Video Modeling
In this session we will present procedures for teaching a variety of skills using video modeling. We will review a curriculum including social skills, self-help skills and vocational skills for teaching children with autism. We will describe how to develop scripts, video tape models and teach using video modeling. We will also review our most recent work identifying necessary prerequisite skills for video modeling instruction to be most successful. We will discuss the most effective components of creating video models and research to support these recommendations. We will introduce the procedure of video prompting, with and without response prompting procedures. We will also discuss the advantages of this teaching procedure and implications for this technology as an easy and effective strategy for teachers and parents to use to teach children.
Participants will learn to:
Workshop # 5 (OBM, DD - Intro)
Staff Training for Organizations
Staff training can be a necessary component to target organizational outcomes. However, with increasing budget restrictions, we are charged to do more with less. Given this concept and an increasing need for a more competitive service, this workshop presents ways to target staff training efficiently and effectively. Organizations should learn to appropriately develop staff training to save time in meeting the needs of the service. The goal of this workshop is to provide participants with a working model of staff training that can be applied to various agencies. During the workshop, presenters will review specific analysis, implementation, and follow-up for training development. This is a 'train-the-trainer' approach that can be applied to individual or group training.
Participants will learn:
Sat., Feb. 18, 2012 1:00 p.m. 4:00 p.m.
(see other workshops available Wed. 9am - 4pm, Sat. 9am - 12pm and Sat. 9am - 4pm) (top)
Workshop # 6 (OBM, AUT - Intermed)
Managing a Human Service Agency Using Human Performance Technology
This workshop introduces a comprehensive approach for analyzing and managing the performance of a school, agency, or program as a system. Understanding and appreciating an organization's systemic nature is the key to managing an organization's operations and achieving its organizational goals. In this workshop, participants will be introduced to several tools enlisted from human performance technology (HPT) to help them assess and understand the host of contextual variables operating inside and outside of their organization that might influence the accomplishment of mission related objectives. These tools drive the analysis and design of performance systems that can be maintained by employees within your organization.
Well-suited for executive directors, program directors, and staff supervisors this presentation will show how Optimal's approach to organizational management can be adopted by ABA service provider agencies to improve organization level performance.
Participants will learn to describe:
Workshop # 7 (DD, ED - Intermed)
Trial-based Functional Analysis: What It Is and How To Do It
Functional analyses are commonly used to determine the function of problem behavior. They involve the direct manipulation of various environmental variables to determine their influence on problem behavior. Although research supports the use of functional analyses to identify the environmental variables that maintain problem behavior and to direct treatment development, functional analyses may not always be feasible to conduct in all settings (e.g., schools) due to limited resources, primarily access to controlled environments. The trial-based functional analysis (Bloom, Iwata, Fritz, Roscoe, & Carreau, 2011) was developed to allow teachers to conduct functional analysis in their classrooms, with brief assessment trials embedded into ongoing activities. This workshop is designed to introduce participants to the trial-based functional analysis, exploring its strengths and weaknesses and identifying conditions under which it is appropriate (and ethical). Participants will discuss the ethics of trial-based functional analysis, including problems which may arise when using this assessment procedure. Participants will learn how to conduct trial-based functional analyses, how to collect, graph and analyze data and how to use results as the foundation for treatment development. Participants will view video clips of trial-based FAs and role-play different trial-types as well as practice data collection, graphing and analysis skills. Participants will receive trial description handouts as well as blank data sheets and graphs. It is recommended that participants have an intermediate knowledge level, and have some experience with functional analysis to receive maximum benefit from the workshop.
Participants will:
Workshop # 8 (CM - Intro)
Behavioral Relaxation: Training and Scale
Relaxation techniques are an integral part of the successful treatment of those exhibiting anxiety-related, pain-related, and/or anger-related behaviors. The sooner a client learns relaxation and other types of self-control techniques, the safer his/her internal and external environments may become. In addition, due to limitations in funding, providers must often demonstrate that extensive treatment progress has been made within a relatively short period of time.
Poppen's (1998) Behavioral Relaxation Scale (BRS) is an assessment tool for measuring the progress of an individual demonstrating the 10 overt relaxed behaviors taught to criterion with Behavioral Relaxation Training (BRT). BRT can be an effective part of treatment for individuals with emotional/mental disorders, hyperactivity, schizophrenia, traumatic brain injury, physical limitations, and/or restricted cognitive/intellectual capabilities.
During this workshop, the participants will hear a presentation about physiological effects of relaxation, using relaxation training to treat psychological and physical disorders, and Poppen's (1998) development of BRT and the BRS. The instructor will demonstrate each of the 10 postures included in Upright Behavioral Relaxation Training (URT) through labeling, topographical description, and modeling. The participants will practice diaphragmatic breathing, then imitate the other 9 relaxed behaviors of URT while viewing an instructor as model. The instructor will provide individualized corrective feedback and teach participants how to provide corrective feedback to one another. Once participants are proficient in demonstrating URT and can verbally describe these 10 relaxed behaviors and corresponding examples of unrelaxed behaviors, they will be taught how to assess URT using the BRS.
Participants will learn to:
Workshop # 9 (DD, ED - Intro)
Maximizing Motivation During ABA-Based Interventions
This workshop will provide a comprehensive discussion of motivation as it pertains to ABA-based interventions for individuals with developmental disabilities. Participants will learn how to establish conditioned and generalized conditioned reinforcers in order to maximize learning across a variety of settings including home, school, workplace, and community. Particular emphasis will be placed on establishing control by "natural" reinforcers appropriate to the learning environment (i.e., money in the work place, letter grades in the classroom, social approval in the community). Additionally, guidelines for identifying potential reinforcers including how and when preference assessments should be used will be presented. Finally, the importance of motivational variables (i.e., establishing and abolishing operations) and the role of habituation in operant responding will be discussed.
Participants will be able to:
Sat., Feb. 18, 2012 9:00 a.m. 4:00 p.m.
(see other workshops available Wed. 9am - 4pm, Sat. 9am - 12pm and Sat. 1pm - 4pm) (top)
Workshop # 10 (DD, PEL - Intermed)
CE: BACB_EPB, BBS, SLPAB, under review for MCEP
Self-injurious Behavior: An Introduction to Definitions, Demographics, Causes, Assessment, Treatment and Ethics
Self-injurious behavior is a complex, disturbing and bewildering phenomena that has been described as "frightening in its maladaptiveness" (Simeon & Hollander, 2001).
In persons with developmental and intellectual disabilities, self-injury ranges from mild and seemingly innocuous behaviors to severe, intense and destructive acts. While a wealth of information exists on self-injurious behavior (as evidenced by multitudes of journal articles, reviews and studies on self-injury), practitioners and students are often unprepared and unequipped to address the complexities of this behavior.
In this introductory workshop, we will cover information for students, new as well as seasoned practitioners, to better understand and address self-injury. Because of the complexities of this behavior, this workshop should be considered just one of many steps taken by practitioners to develop the necessary skills and knowledge to assess and treat self-injury.
We will review:
Participants will:


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spoiler: According to video: Its possible that geth can be allied with Cerberus specifically or the Reaper. I really hoping by possible they mean if you handed Legion over to Cerberus then they are Cerberus allies, if you didnt hand Legion over, but didnt complete its loyalty quest then the Geth are with the reapers
but the third option better be if you completed Legion side quest then they better be on Shepards side or fighting the quarians depending on other choices
Going to be upset if I did all that crap for Legion and that artificial bastard stabs Shepard in the back.
spoiler:Well, given the schism w/in Geth "civilization" and the fact that they aren't completely obliterated in ME2 no matter what you do, it's possible that any remaining geth from Legion's "final solution" could still end up working for the reapers.


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Pteropus voeltzkowi
|Scientific Name:
|Pteropus voeltzkowi
|Species Authority:
|Matschie, 1909
Common Name(s):
|Red List Category & Criteria:
|Vulnerable D2 ver 3.1
|Year Published:
|Date Assessed:
|Mickleburgh, S., Hutson, A.M., Bergmans, W. & Howell, K.
|Hutson, A.M., Racey, P.A. (Chiroptera Red List Authority) & Cox, N. (Global Mammal Assessment Team)
Listed as Vulnerable because it is known from only a single location (Pemba Island), where ongoing active conservation activities have significantly reduced the plausibility of future declines of this species.
|Previously published Red List assessments:
|Range Description:
|This species is endemic to the island of Pemba in Tanzania, where it occurs at elevations from sea level to 45 m asl.
|Countries occurrence:
Native:Tanzania, United Republic of
|Upper elevation limit (metres):
|Range Map:
|Click here to open the map viewer and explore range.
|In the early 1990's the population of this species appears to have been reduced to a few hundred animals at most (Mickleburgh et al. 1991). Entwistle and Corp (1997) reported that in 1997, 94% of the of population was restricted to 10 roosts (of 41 in total) with a total estimate of 4,600 to 5,500 individuals. Entwistle (2001) reported that more recent local participation in survey work had helped to give a more accurate population estimate of ~6,900 bats (Trewhella et al. 2005). The population of bats has continued to increase and by the end of 2006 there were ~19,000 animals (Juma 2007).
|Current Population Trend:
|Additional data:
|Habitat and Ecology:
|This species has been recorded from primary forest, secondary forest, undisturbed traditional grave yards and mangroves. Will roost in several different species of trees, including large examples of non-native trees (such as Mango). According to Pakenham (1984) the species has been recorded roosting on the small islands off Pemba's coast, with bats flying to the mainland at sunset to forage. Seehausen (1990) concluded from interviews with inhabitants of Pemba that the species used to occur in the western parts of the island, which was once covered with rain forest, and not in the eastern, drier parts.
|Major Threat(s):
|Much of the natural forest habitat of this bat has been cleared or severely fragmented. The species has been hunted for food with the use of shotguns replacing traditional methods, resulting in an unsustainable use (Entwistle and Corp 1997). As of 2005, hunting had been reduced but not stopped on Pemba (Trewhella et al. 2005). An additional threat is posed by the collision of bats with overhead electric cables.
|Conservation Actions:
|Ongoing awareness raising on the importance and uniqueness of the endemic fruit bat, and the need for sustainable hunting, has been undertaken through environmental education programmes (Trewhella et al. 2005; Juma 2007). Income for the local community is being generated through bat related ecotourism activities (Juma 2007). It has been reported from the recently gazetted Ngezi-Vumawimbi Nature Forest Reserve and Msitu Kuu Forest(Pakenham 1984; Juma 2007). Illegal logging and the invasive umbrella tree (Maesopsis eminii), that degrades the habitat of this bat, are being controlled within the Nature Forest Reserve (Juma 2007). This species is listed on Appendix II of CITES.
|Mickleburgh, S., Hutson, A.M., Bergmans, W. & Howell, K. 2008. Pteropus voeltzkowi. The IUCN Red List of Threatened Species 2008: e.T18768A8598836. . Downloaded on 27 June 2016.
|To make use of this information, please check the <Terms of Use>.
|If you see any errors or have any questions or suggestions on what is shown on this page, please provide us with feedback so that we can correct or extend the information provided


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N -23º 33' 28.09" / W -46º 39' 38.92"
Tel: (55) 11 2184-1600Fax: (55) 11 2184-1633
Check-in after 14:00h
Check-out until 12:00h
The Supreme Room Queen offers refinement to Meliá Paulista guests. The room has a beautiful casual décor and a cozy outfit. Located on the highest floors of the hotel and with a beautiful view of São Paulo, the Supreme Room is an amazing option for those who seek comfort and luxury.
With 37m², it is divided into two spaces: bedroom and living room. In the first room, a beautiful queen-size bed, alarm clock with radio, telephone and LCD TV with cable channels. In the second space, a desk, a comfortable armchair, a dining room, a fridge and another phone. The room also features complimentary wireless internet.
If you are looking for luxury and functionality in a hotel in São Paulo, this is the ideal option.
*Service subject to additional charges


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ARCHAEOLOGISTS will carry out a survey of the Barnsley Pals' training ground this week to determine the layout of the site during World War One.
Elmet Archaeological Services Ltd has received £9,600 in lottery funding to carry out the work at the former Silverwood Newhall Training Camp at Silkstone, now Silverwood Scout Camp on Barnsley Road.
The project, from April 14 to 27, marks the centenary year of the war and the idea is to get Barnsley folk involved with the archaeological, geophysical and landscape surveys of the site.
It is hoped any finds will add to the understanding of the Barnsley Pals' place in the conflict, as well as the local history of Barnsley.
Archaeology manager, Alex Sotheran, said: "We're a community archaeology company and we're interested in getting people involved with their local heritage.
"We are only looking at a particular barracks area in the first instance. What we are hoping to find is an accurate layout of where the barracks were.
"The problem is at some point over the last 100 years a lot of the land was filled in and only about a quarter of the site might be from World War One.
"We'll be doing geophysical and landscape surveys and the geophysical survey should pick up any remains of post holes in the ground which we can use to map out the site of the barracks."
All volunteers for the project will be trained in archaeological surveying techniques under the guidance of professional archaeologists.


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Half of Pregnant Women, Newborns Risk Flu »
"Sept. 27, 2012 -- Half of pregnant women don't get flu shots, putting themselves and their child at risk of severe flu.
The finding comes from a CDC survey showing that during last year's flu season, 53% of pregnant women did not get "...
Read the Half of Pregnant Women, Newborns Risk Flu article »
Mechanism Of Action
Oseltamivir is an antiviral drug with activity against influenza virus [see Microbiology].
Absorption and Bioavailability
Oseltamivir is readily absorbed from the gastrointestinal tract after oral administration of oseltamivir phosphate and is extensively converted predominantly by hepatic esterases to oseltamivir carboxylate. At least 75% of an oral dose reaches the systemic circulation as oseltamivir carboxylate. Exposure to oseltamivir is less than 5% of the total exposure after oral dosing (see Table 8).
Table 8 : Mean (% CV)
Pharmacokinetic Parameters of Oseltamivir and Oseltamivir Carboxylate Following
Multiple Dosing of 75 mg Capsules Twice Daily (n=20)
|Oseltamivir Carboxylate
|Cmax (ng/mL)
|65 (26)
|348 (18)
|AUC0-12h (ngh/mL)
|112 (25)
|2719 (20)
Plasma concentrations of oseltamivir carboxylate are proportional to doses up to 500 mg given twice daily.
Coadministration with food has no significant effect on the peak plasma concentration (551 ng/mL under fasted conditions and 441 ng/mL under fed conditions) and the area under the plasma concentration time curve (6218 ng·h/mL under fasted conditions and 6069 ng·h/mL under fed conditions) of oseltamivir carboxylate.
The volume of distribution (Vss) of oseltamivir carboxylate, following intravenous administration in 24 subjects, ranged between 23 and 26 liters.
The binding of oseltamivir carboxylate to human plasma protein is low (3%). The binding of oseltamivir to human plasma protein is 42%, which is insufficient to cause significant displacement-based drug interactions.
Oseltamivir is extensively converted to oseltamivir carboxylate by esterases located predominantly in the liver. Neither oseltamivir nor oseltamivir carboxylate is a substrate for, or inhibitor of, cytochrome P450 isoforms.
Absorbed oseltamivir is primarily ( > 90%) eliminated by conversion to oseltamivir carboxylate. Plasma concentrations of oseltamivir declined with a half-life of 1 to 3 hours in most subjects after oral administration. Oseltamivir carboxylate is not further metabolized and is eliminated in the urine. Plasma concentrations of oseltamivir carboxylate declined with a half-life of 6 to 10 hours in most subjects after oral administration. Oseltamivir carboxylate is eliminated entirely ( > 99%) by renal excretion. Renal clearance (18.8 L/h) exceeds glomerular filtration rate (7.5 L/h), indicating that tubular secretion occurs in addition to glomerular filtration. Less than 20% of an oral radiolabeled dose is eliminated in feces.
Specific Populations
Renal Impairment
Administration of 100 mg of oseltamivir phosphate twice daily for 5 days to subjects with various degrees of renal impairment showed that exposure to oseltamivir carboxylate is inversely proportional to declining renal function.
Population-derived pharmacokinetic parameters were determined for patients with varying degrees of renal function including ESRD patients on hemodialysis. Median simulated exposures of oseltamivir carboxylate for recommended treatment and prophylaxis regimens are provided in Table 9. The pharmacokinetics of oseltamivir have not been studied in ESRD patients not undergoing dialysis [see DOSAGE AND ADMINISTRATION].
Table 9 : Simulated Median Treatment Exposure Metrics
of Oseltamivir Carboxylate in Normal, Renally Impaired and ESRD Patients on
|Renal Function/ Impairment
|Normal Creatinine Clearance 90-140 mL/min
|Mild Creatinine Clearance 60-90 mL/min
|Moderate Creatinine Clearance 30-60 mL/min
|Severe Creatinine Clearance 10-30 mL/min
|ESRD Creatinine Clearance < 10 mL/min on Hemodialysis
|Recommended Treatment Regimens
|PK exposure parameter
|75 mg twice daily
|75 mg twice daily
|30 mg twice daily
|30 mg once daily
|30 mg every HD cycle
|Cmin (ng/mL)
|Cmax (ng/mL)
|AUC48 (ng-h/mL)*
|Recommended Prophylaxis Regimens
|PK exposure parameter
|75 mg once daily
|75 mg once daily
|30 mg once daily
|30 mg every other day
|30 mg alternate HD cycle
|Cmin (ng/mL)
|Cmax (ng/mL)
|AUC48 (ng-hr/mL)*
|*AUC normalized to 48 hours.
In continuous ambulatory peritoneal dialysis (CAPD) patients, the peak concentration of oseltamivir carboxylate following a single 30 mg dose of oseltamivir or once weekly oseltamivir was approximately 3-fold higher than in patients with normal renal function who received 75 mg twice daily. The plasma concentration of oseltamivir carboxylate on Day 5 (147 ng/mL) following a single 30 mg dose in CAPD patients is similar to the predicted Cmin (160 ng/mL) in patients with normal renal function following 75 mg twice daily. Administration of 30 mg once weekly to CAPD patients resulted in plasma concentrations of oseltamivir carboxylate at the 168 hour blood sample of 63 ng/mL, which were comparable to the Cmin in patients with normal renal function receiving the approved regimen of 75 mg once daily (40 ng/mL).
Hepatic Impairment
In clinical studies oseltamivir carboxylate exposure was not altered in subjects with mild or moderate hepatic impairment [see DOSAGE AND ADMINISTRATION and Use In Specific Populations].
Pregnant Women
A pooled population pharmacokinetic analysis indicates that the TAMIFLU dosage regimen [see DOSAGE AND ADMINISTRATION] resulted in lower exposure to the active metabolite in pregnant women (n=59) compared to non-pregnant women (n=33). However, this predicted exposure is expected to have activity against susceptible influenza virus strains and there are insufficient pharmacokinetics and safety data to recommend a dose adjustment for pregnant women.
Pediatric Subjects (1 to 12 years of age)
The pharmacokinetics of oseltamivir and oseltamivir carboxylate have been evaluated in a single-dose pharmacokinetic study in pediatric subjects aged 5 to 16 years (n=18) and in a small number of pediatric subjects aged 3 to 12 years (n=5) enrolled in a clinical trial. Younger pediatric subjects cleared both the prodrug and the active metabolite faster than adult subjects resulting in a lower exposure for a given mg/kg dose. For oseltamivir carboxylate, apparent total clearance decreases linearly with increasing age (up to 12 years). The pharmacokinetics of oseltamivir in pediatric subjects over 12 years of age are similar to those in adult subjects.
Pediatric Subjects (2 weeks to less than 1 year of age)
The pharmacokinetics of oseltamivir and oseltamivir carboxylate have been evaluated in two open-label studies of pediatric subjects less than one year of age (n=122) infected with influenza. Apparent clearance of the active metabolite decreases with decreasing age in subjects less than 1 year of age; however the oseltamivir and oseltamivir carboxylate exposure following a 3 mg/kg dose in subjects under 1 year of age is expected to be within the observed exposures in adults and adolescents receiving 75 mg twice daily and 150 mg twice daily.
Geriatric Patients
Exposure to oseltamivir carboxylate at steady-state was 25% to 35% higher in geriatric subjects (age range 65 to 78 years) compared to young adults given comparable doses of oseltamivir. Half-lives observed in the geriatric subjects were similar to those seen in young adults. Based on drug exposure and tolerability, dose adjustments are not required for geriatric patients for either treatment or prophylaxis [see DOSAGE AND ADMINISTRATION].
Mechanism of Action
Oseltamivir phosphate is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. Oseltamivir carboxylate is an inhibitor of influenza virus neuraminidase affecting release of viral particles. The median IC50 values of oseltamivir against influenza A/H1N1, influenza A/H3N2, and influenza B clinical isolates were 2.5 nM (range 0.93-4.16 nM, N=74), 0.96 nM (range 0.13-7.95 nM, N=774), and 60 nM (20-285 nM, N=256), respectively, in a neuraminidase assay with a fluorescently labeled MUNANA substrate.
Antiviral Activity
The antiviral activity of oseltamivir carboxylate against laboratory strains and clinical isolates of influenza virus was determined in cell culture. The concentrations of oseltamivir carboxylate required for inhibition of influenza virus in cell culture were highly variable depending on the assay method used and the virus tested. The 50% and 90% effective concentrations (EC50 and EC90) were in the range of 0.0008 μM to > 35 μM and 0.004 μM to > 100 μM, respectively (1 μM=0.284 μg/mL). The relationship between the antiviral activity in cell culture, inhibitory activity in the neuraminidase assay, and the inhibition of influenza virus replication in humans has not been established.
Cell culture studies: Influenza A virus isolates with reduced susceptibility to oseltamivir carboxylate have been recovered by serial passage of virus in cell culture in the presence of increasing concentrations of oseltamivir carboxylate. Reduced susceptibility of influenza virus to inhibition by oseltamivir carboxylate may be conferred by amino acid substitutions in the viral neuraminidase and/or hemagglutinin proteins.
Clinical studies: Reduced susceptibility isolates have been obtained during treatment with oseltamivir and from sampling during community surveillance studies. Changes in the viral neuraminidase that have been associated with reduced susceptibility to oseltamivir carboxylate are summarized in Table 10. The clinical impact of this reduced susceptibility is unknown. Hemagglutinin substitutions associated with oseltamivir resistance include A28T and R124M in influenza A H3N2 and H154Q in H1N9, a reassortant human/avian virus.
Table 10 : Neuraminidase Amino Acid Substitutions
Associated with Reduced Susceptibility to Oseltamivir
|Amino Acid Substitution*
|Influenza A N1 (N1 numbering in brackets)
|Roche clinical trial, publication
|Roche clinical trial, publication
|Influenza A N2
|Roche clinical trial, publication
|SASG245-248 deletion
|Roche clinical trial, publication
|Roche clinical trials, publication
|Influenza B (B numbering in brackets)
|Roche clinical trial, publication
|* All numbering is N2, except where indicated
Selection of influenza A viruses resistant to oseltamivir can occur at higher frequencies in children. The incidence of oseltamivir treatment-associated resistance in pediatric treatment studies has been detected at rates of 27% to 37% and 3% to 18% (3/11 to 7/19 and 1/34 to 9/50 post-treatment isolates, respectively) for influenza A/H1N1 and influenza A/H3N2, respectively. The frequency of resistance selection to oseltamivir and the prevalence of such resistant virus vary seasonally and geographically.
Circulating seasonal influenza strains expressing neuraminidase resistance-associated substitutions have been observed in individuals who have not received oseltamivir treatment. The oseltamivir resistance-associated substitution H275Y was found in > 99% of US circulating 2008 H1N1 influenza virus isolates. The 2009 H1N1 influenza virus ("swine flu") was almost uniformly susceptible to oseltamivir. Prescribers should consider available information from the CDC on influenza virus drug susceptibility patterns and treatment effects when deciding whether to use TAMIFLU.
Cross-resistance between oseltamivir and zanamivir has been observed in neuraminidase biochemical assays. The H275Y (N1 numbering) or N294S (N2 numbering) oseltamivir resistance-associated substitutions observed in the N1 neuraminidase subtype, and the E119V or N294S oseltamivir resistance-associated substitutions observed in the N2 subtype (N2 numbering), are associated with reduced susceptibility to oseltamivir but not zanamivir. The Q136K and K150T zanamivir resistance-associated substitutions observed in N1 neuraminidase, or the S250G zanamivir resistance-associated substitutions observed in influenza B virus neuraminidase, confer reduced susceptibility to zanamivir but not oseltamivir. The R292K oseltamivir resistance-associated substitution observed in N2, and the I222T, D198E/N, R371K, or G402S oseltamivir resistance-associated substitutions observed in influenza B virus neuraminidase, confer reduced susceptibility to both oseltamivir and zanamivir. These examples do not represent an exhaustive list of cross resistance-associated substitutions and prescribers should consider available information from the CDC on influenza drug susceptibility patterns and treatment effects when deciding whether to use TAMIFLU.
No single amino acid substitution has been identified that could confer cross-resistance between the neuraminidase inhibitor class (oseltamivir, zanamivir) and the M2 ion channel inhibitor class (amantadine, rimantadine). However, a virus may carry a neuraminidase inhibitor associated substitution in neuraminidase and an M2 ion channel inhibitor associated substitution in M2 and may therefore be resistant to both classes of inhibitors. The clinical relevance of phenotypic cross-resistance evaluations has not been established.
Immune Response
No influenza vaccine/oseltamivir interaction study has been conducted. In studies of naturally acquired and experimental influenza, treatment with TAMIFLU did not impair normal humoral antibody response to infection.
Animal Toxicology And/Or Pharmacology
Single, oral administration of ≥ 657 mg/kg oseltamivir resulted in toxicity, including death, in juvenile 7 day old rats, but had no effect on adult rats. No toxicity was observed after repeated administration of up to 500 mg/kg oseltamivir to developing juvenile rats 7 to 21 days old. This 500 mg/kg dose was approximately 280 and 14 times the human systemic exposure (AUC0-24h) of oseltamivir and oseltamivir carboxylate, respectively. Clinical relevance of the juvenile rat study finding for young infants is unknown.
Clinical Studies
Treatment Of Influenza
Adult and Adolescent Subjects (13 years of age and older)
Two placebo-controlled double-blind clinical trials were conducted: one in the U.S. and one outside the U.S. Subjects were eligible for these trials if they had fever > 100°F, accompanied by at least one respiratory symptom (cough, nasal symptoms, or sore throat) and at least one systemic symptom (myalgia, chills/sweats, malaise, fatigue, or headache) and influenza virus was known to be circulating in the community. In addition, all subjects enrolled in the trials were allowed to take fever-reducing medications.
Of 1355 subjects enrolled in these two trials, 849 (63%) subjects were influenza-infected (age range 18 to 65 years; median age 34 years; 52% male; 90% Caucasian; 31% smokers). Of the 849 influenza-infected subjects, 95% were infected with influenza A, 3% with influenza B, and 2% with influenza of unknown type.
TAMIFLU was started within 40 hours of onset of symptoms. Subjects participating in the trials were required to self-assess the influenza-associated symptoms as "none," "mild," "moderate," or "severe." Time to improvement was calculated from the time of treatment initiation to the time when all symptoms (nasal congestion, sore throat, cough, aches, fatigue, headaches, and chills/sweats) were assessed as "none" or "mild." In both studies, at the recommended dose of TAMIFLU 75 mg twice daily for 5 days, there was a 1.3 day reduction in the median time to improvement in influenza-infected subjects receiving TAMIFLU compared to subjects receiving placebo. Subgroup analyses of these studies by gender showed no differences in the treatment effect of TAMIFLU in men and women.
In the treatment of influenza, no increased efficacy was demonstrated in subjects receiving treatment of 150 mg TAMIFLU twice daily for 5 days.
Geriatric Subjects
Three double-blind placebo-controlled treatment trials were conducted in subjects ≥ 65 years of age in three consecutive seasons. The enrollment criteria were similar to that of adult trials with the exception of fever being defined as > 97.5°F. Of 741 subjects enrolled, 476 (65%) subjects were influenza-infected. Of the 476 influenza-infected subjects, 95% were infected with influenza type A and 5% with influenza type B.
In the pooled analysis, at the recommended dose of TAMIFLU 75 mg twice daily for 5 days, there was a 1-day reduction in the median time to improvement in influenza-infected subjects receiving TAMIFLU compared to those receiving placebo (p=NS). However, the magnitude of treatment effect varied between studies.
Pediatric Subjects (1 to 12 years of age)
One double-blind placebo-controlled treatment trial was conducted in pediatric subjects aged 1 to 12 years (median age 5 years), who had fever ( > 100°F) plus one respiratory symptom (cough or coryza) when influenza virus was known to be circulating in the community. Of 698 subjects enrolled in this trial, 452 (65%) were influenza-infected (50% male; 68% Caucasian). Of the 452 influenza-infected subjects, 67% were infected with influenza A and 33% with influenza B.
The primary endpoint in this study was the time to freedom from illness, a composite endpoint that required 4 individual conditions to be met. These were: alleviation of cough, alleviation of coryza, resolution of fever, and parental opinion of a return to normal health and activity. TAMIFLU treatment of 2 mg/kg twice daily, started within 48 hours of onset of symptoms, significantly reduced the total composite time to freedom from illness by 1.5 days compared to placebo. Subgroup analyses of this study by gender showed no differences in the treatment effect of TAMIFLU in male and female pediatric subjects.
Pediatric Subjects (2 weeks to less than 1 year of age)
Two open label trials evaluated the safety and pharmacokinetics of oseltamivir and oseltamivir carboxylate in influenza-infected pediatric subjects 2 weeks to less than 1 year of age (including premature infants at least 36 weeks post conceptional age). Subjects received TAMIFLU at doses ranging from 2 to 3.5 mg/kg twice daily for 5 days depending on subject age. These clinical trials were not designed to evaluate clinical efficacy or virologic response.
Of the 136 subjects under the age of 1 year enrolled and dosed in the trials, the majority of the subjects were male (55%), white (79%), non-Hispanic (74%), full term (76%) and infected with influenza A (80%). Pharmacokinetic data indicated that a dose of 3 mg/kg twice daily in pediatric subjects 2 weeks to less than 1 year of age provided TAMIFLU concentrations similar to or higher than those observed in older pediatric subjects and adults receiving the approved dose and, by extrapolation, is expected to provide similar efficacy. The trials provided adequate safety data to support this dose selection [see ADVERSE REACTIONS].
Prophylaxis Of Influenza
Adult and Adolescent Subjects (13 years of age and older)
The efficacy of TAMIFLU in preventing naturally occurring influenza illness has been demonstrated in three seasonal prophylaxis studies and a postexposure prophylaxis study in households. The primary efficacy parameter for all these studies was the incidence of laboratory-confirmed clinical influenza. Laboratory-confirmed clinical influenza was defined as oral temperature ≥ 99.0°F/37.2°C plus at least one respiratory symptom (cough, sore throat, nasal congestion) and at least one constitutional symptom (aches and pain, fatigue, headache, chills/sweats), all recorded within 24 hours, plus either a positive virus isolation or a four-fold increase in virus antibody titers from baseline.
In a pooled analysis of two seasonal prophylaxis studies in healthy unvaccinated adults (aged 13 to 65 years), TAMIFLU 75 mg once daily taken for 42 days during a community outbreak reduced the incidence of laboratory-confirmed clinical influenza from 5% (25/519) for the placebo group to 1% (6/520) for the TAMIFLU group.
In a seasonal prophylaxis study in elderly residents of skilled nursing homes, TAMIFLU 75 mg once daily taken for 42 days reduced the incidence of laboratory-confirmed clinical influenza from 4% (12/272) for the placebo group to < 1% (1/276) for the TAMIFLU group. About 80% of this elderly population were vaccinated, 14% of subjects had chronic airway obstructive disorders, and 43% had cardiac disorders.
In a study of postexposure prophylaxis in household contacts (aged ≥ 13 years) of an index case, TAMIFLU 75 mg once daily administered within 2 days of onset of symptoms in the index case and continued for 7 days reduced the incidence of laboratory-confirmed clinical influenza from 12% (24/200) in the placebo group to 1% (2/205) for the TAMIFLU group. Index cases did not receive TAMIFLU in the study.
Pediatric Subjects (1 to 12 years of age)
The efficacy of TAMIFLU in preventing naturally occurring influenza illness has been demonstrated in a randomized, open-label, postexposure prophylaxis study in households that included pediatric subjects aged 1 to 12 years, both as index cases and as family contacts. All index cases in this study received treatment. The primary efficacy parameter for this study was the incidence of laboratory-confirmed clinical influenza in the household. Laboratory-confirmed clinical influenza was defined as oral temperature ≥ 100°F/37.8°C plus cough and/or coryza recorded within 48 hours, plus either a positive virus isolation or a four-fold or greater increase in virus antibody titers from baseline or at illness visits. Among household contacts 1 to 12 years of age not already shedding virus at baseline, TAMIFLU for oral suspension 30 mg to 60 mg taken once daily for 10 days reduced the incidence of laboratory-confirmed clinical influenza from 17% (18/106) in the group not receiving prophylaxis to 3% (3/95) in the group receiving prophylaxis.
Immunocompromised Subjects
A double-blind, placebo-controlled study was conducted for seasonal prophylaxis of influenza in 475 immunocompromised subjects (including 18 pediatric subjects 1 to 12 years of age) who had received solid organ (n=388; liver, kidney, liver and kidney) or hematopoietic stem cell transplants (n=87). Median time since transplant for solid organ transplant recipients was 1105 days for the placebo group and 1379 days for the oseltamivir group. Median time since transplant for hematopoietic stem cell transplant recipients was 424 days for the placebo group and 367 days for the oseltamivir group. Approximately 40% of subjects received influenza vaccine prior to entering the study. The primary efficacy endpoint for this study was the incidence of confirmed, clinical influenza, defined as oral temperature > 99.0°F/37.2°C plus cough and/or coryza, all recorded within 24 hours, plus either a positive virus culture or a four-fold increase in virus antibody titers from baseline. The incidence of confirmed clinical influenza was 3% (7/238) in the group not receiving TAMIFLU compared with 2% (5/237) in the group receiving TAMIFLU; this difference was not statistically significant. A secondary analysis was performed using the same clinical symptoms and RT-PCR for laboratory confirmation of influenza infection. Among subjects who were not already shedding virus at baseline, the incidence of RTPCR-confirmed clinical influenza infection was 3% (7/231) in the group not receiving TAMIFLU and < 1% (1/232) in the group receiving TAMIFLU.
Last reviewed on RxList: 12/15/2014
This monograph has been modified to include the generic and brand name in many instances.
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July 10, 2012
Celebrating 40 Years of Title IX
UCLA Athletics continues its celebration of the 40th Anniversary of Title IX with a series of profiles of UCLA's Title IX 40. This group of 40 Bruin women were game-changers in the Title IX era. The next two profiles are of a pair of Hall of Famers from the 1970's - softball player and former head coach Sue Enquist and women's basketball legend Ann Meyers Drysdale.
Sue Enquist, Softball (1975-78)
During her 31 years with the UCLA Softball team, Sue Enquist achieved elite status at all levels - player, assistant coach, co-head coach and head coach - and was involved in a total of 11 national championships.
As a standout player with a career batting average of .401 from 1975-78, Enquist led the Bruins to their first national championship, the 1978 AIAW crown. That year, she became UCLA's first-ever softball All-American and led the team with a .391 batting average.
After her collegiate career, Enquist was a three-time American Softball Association (ASA) All-American for the Raybestos Brakettes and led the team to four ASA National Championships. In international play, Enquist earned gold medals at three National Sports Festivals, the 1978 World Championships and the 1979 Pan American Games.
Enquist moved into coaching soon after her playing career, serving as a UCLA assistant coach under Sharron Backus from 1980-88. During those years, UCLA won four NCAA Championships - 1982 (the first-ever NCAA Softball Championship), 1984, 1985 and 1988. Enquist was promoted to co-head coach with Backus in 1989, and the duo led UCLA to three more NCAA titles in 1989, 1990 and 1992.
After Backus retired at the end of the 1996 season, Enquist became UCLA's sole head coach. In the next 10 years (1997-2006), the Bruins captured three additional NCAA crowns (1999, 2003 and 2004). Enquist retired in 2006 with a UCLA career coaching record of 887-175-1 in 18 years as a co-head coach and head coach (her .835 winning percentage puts her at the top of the NCAA charts for Division I head softball coaches), and she now works on special projects in the UCLA Athletics Development Office.
During her UCLA coaching career, Enquist mentored 60 All-Americans, 31 National team members, 12 Olympians, and seven Honda Award winners. She led UCLA to seven conference championships and was a three-time National and Pac-10 Coach of the Year. Enquist was enshrined into the National Fastpitch Coaches Association Hall of Fame in 2006, the International Women's Sports Hall of Fame in 2008 and was the first Bruin softball player to be inducted into the UCLA Athletics Hall of Fame in 1993. Her Bruin jersey (#6) was retired in 2000.
Ann Meyers (Drysdale), Basketball (1975-78)
Ann Meyers has been at the forefront of women's advancement in sports throughout her career as a basketball player, sports journalist and NBA/WNBA executive.
The first woman to receive a full athletic scholarship to UCLA, Meyers was the first collegiate women's basketball player ever to earn four All-America honors (1975-78). As a senior, she helped lead UCLA to the school's first women's basketball national title and earned the Broderick Cup as the Collegiate Athlete of the Year across all women's sports. Meyers finished her Bruin basketball playing career as UCLA's leader in 12 of 13 school records and still holds the mark for career steals and blocked shots. She led UCLA to a four-year record of 84-14, including a 35-1 mark in Pauley Pavilion and four consecutive conference titles. She had 84 double-digit scoring games, including 36, 20+ single-game scoring outbursts.
A multi-sport UCLA standout, she was a high jumper and pentathlete on the Bruins' 1975 track & field national championship women's squad and also played volleyball on Andy Banachowski's women's team.
In 1979, Meyers became the first (and only) woman to sign a free-agent contract with an NBA franchise (Indiana Pacers). Although she did not make the team, she then went onto to a standout career from 1979-1980 with the New Jersey Gems (Women's Professional Basketball League), earning co-MVP and top scoring honors. Meyers was also a standout for the USA National team and was the first woman to be involved with the squad while still in high school. She helped lead the U.S. to the gold medal at the 1975 Pan American Games and to a silver medal at the 1976 Olympic Games.
Following her playing career, she has served as a network television sports analyst for ESPN, CBS and NBC for nearly 30 years. She has been the women's basketball analyst at four Olympic Games (1984, 2000, 2004, 2008), and from 1997-2002, she was NBC's lead analyst for the WNBA. She also became the first woman ever to do game analysis for an NBA team (Indiana Pacers). Meyers' network career also covered women's and men's college basketball (from 1989-91 she was the radio analyst for UCLA men's basketball) and NCAA softball and women's volleyball. In 2006, she earned the U.S. Sports Academy's Ronald Reagan Media Award, joining an elite list of previous winners, including Howard Cosell, Bob Costas, Keith Jackson and Frank Deford.
As she did during her playing days, Meyers achieved many firsts while being honored for her career. In 1988, she became the first UCLA female student-athlete to be inducted into the UCLA Athletics Hall of Fame. In 1990, she and former teammate Denise Curry joined Bill Walton and Kareem Abdul-Jabbar as the first UCLA basketball players ever to have their jersey numbers retired. In 1993, Meyers was the first UCLA women's basketball player and the third female to be inducted into the Naismith Memorial Basketball Hall of Fame. Additionally, she was inducted into the Halls of Fame for Women's Sports (1987), Women's Basketball (1999 charter class) and FIBA (2007 charter class/International Basketball Federation). In 2002, she was given the NCAA Silver Anniversary Award, honoring her for her life's contributions.
Meyers and her late husband, Los Angeles Dodgers Hall of Fame pitcher Don Drysdale, had three children - sons Don, Jr. and Darren and daughter Drew, a sophomore high jumper on the UCLA women's track and field team.
Since 2006, Meyers has served as President and General Manager of the Phoenix Mercury (WNBA) and Vice President of the Phoenix Suns (NBA). She recently released her autobiography, `You Let Some Girl Beat You? The Story of Ann Meyers Drysdale'.
Previous Title IX 40 Profiles
Karen Moe/Janet Coles
Terry Condon/Jan Palchikoff


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By Dr. Cameron Chai
The Chairman and CEO of EcoSynthetix, John van Leeuwen stated that with a capacity of more than 200 million pounds, the company can now deliver bio-based products to both new as well as to existing paper and paperboard markets. Leeuwen added that the company's low capex model enabled it to invest in a new production system before the demand rises for bio-based products. The company's bio-based polymers provide equivalent performance and at the same they are low-cost when compared to other products. The company believes that large-scale adoption will soon be a reality and that it is well-positioned to meet the demand.
The 80 million pound production line features a sophisticated process automation technology, which provides optimum efficiency and also ensures minimum manual intervention. The system is versatile enough to hold numerous feedstocks. These aspects can promote higher throughput and enhanced margins when compared to the present production line in the firm's U.S. facility.
The latest production line also includes a fully automated packaging system that is equipped with an ultrasonic bag sealing and a strong package weight control. Through this system, the company offers a complete series of packaging options to its customers. These packaging options comprise super-sacks and 25 kg bags. Bulk delivery is also provided by the company.
The production expansion will support EcoSynthetix's business growth in North America. Earlier in November 2011, the company had installed 80 million pounds of capacity in its Netherlands facility.
Source: http://www.ecosynthetix.com/
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June 25, 2014 | Volume 101 / Number 26
Janice Maureen (Christensen) St. Clair, 70, passed away Friday, June 20, 2014, at Valley View Nursing Home in Glasgow, surrounded by family and friends, after courageously battling ALS.
Funeral services will be held at 11 a.m. Thursday, June 26, at the Bell Mortuary, followed by interment at the Highland Cemetery. Please join us afterwards at the VFW Hall for refreshments.
Born Oct. 30, 1943, to Julius and Margaret Christensen, she grew up in rural Hinsdale. She loved hunting, fishing, camping and being outdoors. She always told her grandchildren, "the only toys she had growing up were sti...
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All things Mother Earth Living
by Robyn Griggs Lawrence, Editor at Large
Beware. I'm stepping up on the soapbox for a minute.
I just returned from Phoenix, which has me thinking about water. I'm thinking about water because there's a severe lack of it in central Arizona right now—one of the worst droughts the region has seen in centuries.
Water (and lack of it) was a big topic of conversation as Tucson-based photographer Terry Moore and I spent the day shooting a delightful home in the hills of south Phoenix. Anne Schneider, the delightful homeowner, wisely chose an outdoor shower rather than a swimming pool for cooling off during the height of summer, and the shower runoff feeds into a wash that attracts quail, jack rabbits and coyote. The wash, which runs right by Anne's dining patio and bedroom window, has been a lifesaver for many of these creatures during this barren winter (Phoenix hasn't seen a drop of moisture since September). It's also meant that Anne gets to share her little piece of paradise with the critters, who provide endless entertainment.
Not everyone in the Phoenix area is convinced that conservation is necessary, though. Terry, who's selling his home in Tucson, told us he was about to close on a deal when a well-testing company arrived (per the buyers' contract) to check out whether his well was in working order. To do so, they had to pump out all the water, spilling it without thought into the air. The idea was to empty the well, then see how quickly it refilled—until Terry couldn't stand it anymore and told them to stop (possibly squelching his home sale in the process). I had to love him for taking that stand. (Another example of why I'm so lucky to work with the kind of people who contribute to Natural Home.)
My other water gripe is a little thing, and very possibly it doesn't make a dent in Phoenix's drought crisis. But while I stood at the sink in the airport bathroom to fix a contact lens, the water faucet turned on automatically. Even when I stepped away, it ran and ran—clean water spilling into the sink for no reason at all. It's this kind of mindless waste that makes me crazy. (I have the same kind of indignant reaction when those automatic toilets start randomly flushing.)
So, I admit, Americans' flippant ability to take clean water for granted turns me all stentorian and unattractively righteous. I've quoted the stats in speech after speech: Every day, we Americans take 3,600 billion gallons of water from the earth—enough to fill a line of Olympic-size swimming pools reaching around the earth—while 1 billion people lack access to clean water. I've read that the next great wars will be fought not over oil, but over water. Yet even in a region experiencing an epic drought, automatic faucets spill water down the drain and well testers cavalierly toss it into the air.
Saving water is just such an easy, no-hassle way to lower our impact (as anyone who's heard my little rant about not flushing the toilet every time knows). I can't help but wonder what it will take to get us there.
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