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When last we left The Voice Season 6, Teams Adam and Usher had 4 of their 12 artists selected, while Team Shakira had 3 and Team Blake only 2. Who will get the lucky call-ups (0r button-pushes) tonight?
Batting leadoff is Ryan Whyte Maloney, who's looking forward to being able to make music his career, and not just his hobby. Ryan's version of "Lights" attracts Adam and Blake simultaneously, and then Shakira follows right afterward, apparently keeping good on her promise to push every time Blake does. Usher finally joins the party just as the song is drawing to a close, making Ryan yet another four-chair scoring artist. Usher claims he waited so long just to see if Ryan would "continue to work" for that last button. We're not entirely sure if we believe that.
Let the pitching begin. Note the total difference in approach between the show's two veteran coaches.
Adam: You have a high voice. I have a high voice. We're basically already best friends.
Blake: I have pictures of you in my mind with a helium balloon like [mimes sucking helium].
Ryan decides to base his decision on what his kids would tell him, and signs up for Team Blake. We're not sure if that's the most scientific way to choose your coach, but welcome him to the show anyway.
Deshawn Washington is in the number two spot, hoping to improve the quality of life for his family like many artists before him. His performance of "Twistin' The Night Away" is a welcome departure from the usual song selections we hear during blind auditions. After much deliberation between our coaches, Shakira decides to push for Deshawn, and she gets him uncontested. Adam chides Usher for not making the turn. Too late.
We're also still scouring Los Angeles, land of perpetually undiscovered talent, where we're introduced to a nanny who'd rather be a singing star. Sam Behymer is performing Lorde's "Royals," and gets Adam to turn his chair for her early on. Usher thinks on it before deciding to challenge him. Sam is understandably pretty flustered by their attention, and it's interesting to see Adam and Usher spar, because they're the two who give the most specific feedback to the artists. Usher wins brownie points by mentioning Michelle Chamuel, as Sam is a fan of the Season 4 runner-up, but Sam stuns him in joining Team Adam.
We begin the second half of hour number one with our first montage of rejections this season. Once that's passed, it's time for Brendan Ryan, who's making use of the in-holding room piano. Apparently he's both a singer and an improv comedian, which is a pretty cool combination. He's swinging for the fences with "Love On Top," although you wouldn't know it's a Beyonce song from the way he's arranged it. Sadly, nobody takes a chance on him, and he strikes out. Let's pair him with Season 1's Tim Mahoney and see what happens.
Out in Missouri, we meet Cody and Clint Walker, identical twins who make up the duo named (what else?) Brothers Walker. That makes them the second set of twins to appear on The Voice, after The Morgan Twins. And their version of "Keep Me In Mind" attracts Usher. Hey, Blake, why do you still look so surprised to hear a duo? You know they exist on this show! You even coached one to the finals in Season 4. Down the row, Adam needs some help with the concept of identical twins.
Adam: Wait a second. What the hell is going on here?
Cody: There's two of us.
Adam: But you're the same.
Clarissa Serna follows the twins, performing The Cranberries' "Zombie," which you've already heard because NBC leaked her audition last week. Adam likes what he's hearing; so does Shakira. Blake probably doesn't know this song, but he turns around anyway, and Usher once again waits until the last second to jump in. He's so late Clarissa doesn't even realize he's turned for her. While Blake laughs at him for that, Adam rhapsodizes about Clarissa's performance, and Shakira tries to differentiate between tactics and strategy. It's a fine distinction. After all that noise, Clarissa punches her ticket to Team Shakira.
Now it's time for that thing we still all vehemently hate: the montage of successful auditions. Lindsay Pagano goes to Team Shakira (not to be confused with Lindsey Pavao). Joshua Howard joins Team Adam. And Team Usher picks up Tanner James. Hopefully, we'll get to meet these three obviously talented artists in the battle rounds.
Our next full audition is that of Robert Lee, who brings us "The Weight" by The Band. The fact that Robert doesn't get anyone to turn only adds to the frustration of skipping over three auditions that did attract our coaches.
In New York, there's Melissa Jimenez, who comes to the Voice stage after having worked with Wyclef Jean and losing a record deal. Melissa's version of "If I Ain't Got You" doesn't necessarily compare to the previous takes that have been done on the show or by people that have been on the show (as we're going to insist that Adam Levine still has the best cover), but we give her credit for confusing Shakira by deciding to do part of the song in Spanish.
Usher and Shakira have a meeting of the minds before they both turn for Melissa, who immediately starts fangirling all over Shakira so much it's almost too much. Usher immediately senses that this is a losing battle, even though Blake tries to help him, and he name-drops original artist Alicia Keys. But out of nowhere, Melissa turns sides and picks him as her coach. Yet Blake still likes Shakira more. More importantly, here's Season 5 winner Tessanne Chin in a commercial!
Patrick Thomson's version of the Marshall Tucker Band song "Can't You See" earns him Adam and Blake's ears. Adam is not happy about this, since Blake is apparently in a last clap contest with himself.
Adam: God, even your claps are annoying.
Usher gives Blake a little payback for preferring Shakira, by endorsing Adam as Patrick's coach. The "gargle with broken glass" phrase comes out again, too, and it still isn't that effective or funny. Ultimately, Patrick decides to go with Team Adam, and that ought to be an interesting combination.
There's another montage of rejected singers (possibly the first time we've ever had two such montages in the same episode?) before Allison Bray arrives with her take on Connie Francis' "Where The Boys Are." The song choice initially confounds our coaches, and Shakira considers pushing but doesn't. Adam even wonders why she didn't. Allison might not have made it on theshow, but we suggest she teams up with Team Blake's Noah Lis and they have a throwback jam session.
Our final audition of the night seems like it's perfect for television. Sisaundra Lewis may have taken fashion advice from Sera Hill. She also has a celebrity connection, having worked with music superstar Celine Dion as her vocal director, and Celine provides Carson with a video message to present to her former colleague. The commercial break before this already gave away that Sisaundra turns all four chairs with her take on "Ain't No Way," so the only suspense is who's going to land her for their team. The answer is Blake, of course, since the show's been harping on Blake's string of bad luck all evening.
After three nights of auditions, it's Team Adam 7, Team Blake 4, Team Shakira 6, and Team Usher 7. Blind auditions continue tomorrow at 8 PM ET/PT on NBC. For more on Season 6, you can check out our interview with Team Usher's Bria Kelly as she talks going from America's Got Talent to The Voice.
(c)2014 Brittany Frederick. Appears at Examiner with permission. All rights reserved. No reproduction permitted. Visit my official website and follow me on Twitter at @tvbrittanyf.


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More and more news is rolling in on the Star Trek sequel. We have a finished script, cameras are planning to roll in January and Benicio Del Toro is slated to be a yet-to-be-revealed-villain. Know what we don't have? Dehner. That's right, you heard me. As Issue #1 of the IDW Star Trek series stated, Dehner has been transferred due to a "change of heart" regarding her relationship with McCoy (I personally have had absolutely NO change of heart about McCoy or Karl Urban). If IDW books are canon, that may be a red flag that they have no plans on making Dehner a part of the sequel. I'm not discouraged by this. Disappointed, yes. I'm disappointed that they chose not to include another rich female character in their timeline. However, I certainly haven't given up. It was always my intention to push to play Dehner, but I knew there was a possibility she wouldn't be in the sequel. We still aren't certain of this. Star Trek movies have always diverged from the books and comics.
I do tend to wonder, what's with all the bro-mance? You've already got a Bones/Kirk friendship and a newly-formed Kirk/Spock alliance, so why do we need a Gary Mitchell/Kirk story rehash? A new timeline with our modern perspectives could have meant Nurse Chapel being more than a lovesick puppy pining for a man she couldn't have. Yeoman Rand could have been more than a glorified assistant with a thing for Kirk. If IDW was going to introduce a past relationship between Bones and Dehner, why not explore that in the movies? Isn't sexual tension the making of many great things? We've got to have more than Uhura on the bridge at some point. The TOS movies had Saavik, Ilia and Valeris to name just a few.
If Orci, Kurtzman and Lindelof don't want to bring back TOS female characters, then create someone new. They developed a whole new timeline to be able to do whatever they wanted, so why play it safe? Are they worried the hardcore fans wouldn't accept a new main female bridge character? Regardless, decisions like killing Spock's mother and transferring Dehner have some fans wondering if the writing team can really write strong female characters. On the November, 8 G and T Show, my favorite Star Trek podcast, Teri and Nick discuss this very topic in detail. Teri goes so far as to say that JJ Abrams and co. are afraid of breasts and vagina. Their lively discussion, which mentions my Dehner campaign, inspired this blog entry. It got me thinking, where are all the smart, emotional and tough Star Trek women in the JJ verse? Uhura is definitely not enough. Showing your support for Dehner is letting them know that there's room for more complex female characters.
Remember, do not feel bad for me if we find out Dehner isn't in the script for the sequel. Things can always change. Whether Dehner is a one-line reference in the beginning of the movie or a bigger character, my little campaign is still a success. If I'm just a walk-on extra, this campaign is still a success. If all I get from this is a bit of notoriety and some continued fun with my Trek friends, this campaign is still a success. I believe in doing something for yourself instead of just talking about doing it. Make Me Dehner is my mission to be pro-active about my passion for Star Trek and acting, and I'm not one who backs down easily. Thank you for your support and encouragement. There are more fun Dehner-esque goodies coming your way!

subset: commoncrawl


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George Michael Walker
Position: G-LB-C
Height: 6-0 Weight: 235 lbs.
Born: October 14, 1939 in Petoskey, MI
High School: East Detroit
College: Michigan St. (school history)
Drafted by the New York Titans in the 23rd round (181st overall) of the 1961 AFL Draft.
Weighted Career AV (100-95-...): 13 (6326th overall since 1950)
Promote your website or business by sponsoring this page for $5 on Pro-Football-Reference.com. Your message will replace this ad.
Output includes all games from 1920 to 2015.


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Bonjoch, Anna MD*; Paredes, Roger MD*; Galvez, Juan MD†; Miralles, Celia MD‡; Videla, Sebastia MD*; Martínez, Eva*; Miranda, Jose RN*; Muñoz-Moreno, Jose Antonio BS*; Torre, Javier De la MD§; Prieto, Arturo MD∥; Vilades, Consuelo MD¶; Clotet, Bonaventura MD, PhD*; and the SimplifiHAART Study Group
From the *AIDS Care Unit, Lluita contra le SIDA Foundation, Germans Trias i Pujol Hospital, Universitat Autònoma de Barcelona; †Hospital Virgen de la Macarena, Sevilla; ‡Hospital Xeral de Vigo; §Hospital Costa del Sol, Marbella; ∥Hospital Clínico Universitario, Santiago; and ¶Hospital Juan XXIII, Tarragona, Spain.
Received for publication November 9, 2004; accepted March 17, 2005.
The study received an unrestricted grant from GlaxoSmithKline and Boehringer Ingelheim. The authors had complete control over the data and the final manuscript.
Reprints: Anna Bonjoch, Fundació Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Ctra. de Canyet, s/n, 08916 Badalona, Spain (e-mail: firstname.lastname@example.com).
Objectives: To assess the virologic noninferiority of an antiretroviral treatment simplification with coformulated zidovudine/lamivudine/abacavir (group 1) vs. coformulated zidovudine/lamivudine plus nevirapine (group 2) in HIV-1-infected patients receiving successful first-line highly active antiretroviral therapy.
Methods: This is a prospective, multicenter, open-label, comparative, randomized, noninferiority study. A delta of 15% for differences in virologic suppression <200 copies/mL between groups was prespecified with a 1-sided 0.025 significance level.
Results: A total of 134 patients were included into this study: 68 were allocated to group 1 and 66 to group 2. By intention-to-treat analysis (switch equals failure), the percentage of virologic suppression <200 copies/mL (<50 copies/mL) at week 48 was 71.0% (65.1%) and 73.0% (63.3%) in groups 1 and 2, respectively (estimate for differences [<200 copies/mL]: −2.1, 95% CI: −17.4-13.1, P = 0.783). Thirteen and 14 patients in groups 1 and 2, respectively, discontinued therapy due to adverse events. Dyslipidemia improved in both groups, with a higher improvement in low-density lipoprotein cholesterol (P = 0.049) in group 1.
Conclusions: Group 1 is not inferior to group 2 regarding virologic suppression <200 copies/mL. Both strategies improve lipid profile.
Antiretroviral treatment simplification from protease inhibitor (PI)-based approaches to nonnucleoside analogue (NNRTI)-including combinations preserves the antiviral efficacy of the former while exerting noteworthy benefits on lipid metabolism, treatment adherence, and quality of life.1,2 However, attempts at simplification with coformulated triple-nucleoside analogues (NRTIs) have provided divergent results.3-7 These strategies have a simpler and more comfortable administration, avoiding food constraints; have a beneficial impact on lipid metabolism, leading to fewer requirements of lipid-lowering drugs8; and are not subject to significant drug-drug interactions. However, when triple-NRTI regimens are given to patients with prior suboptimal NRTI drug exposure as a simplification strategy, these regimens clearly perform worse than nevirapine- or efavirenz-based combinations.7 Nevertheless, in patients with neither NRTI-related mutations nor prior suboptimal NRTI exposure, triple-NRTI regimens appear to perform as well as NNRTI-based combinations.
This study aims to prospectively evaluate the efficacy of treatment simplification with coformulated abacavir/lamivudine/zidovudine (fixed-dose combination) vs. coformulated lamivudine/zidovudine plus nevirapine in HIV-1-infected patients whose only antiretroviral experience is an ongoing first-line highly active antiretroviral therapy (HAART) approach that achieved and maintains profound virologic suppression.
This is a multicenter, open-label, blinded, centrally randomized, parallel, comparative, controlled, noninferiority clinical trial. Patients with suppressed viral load at least in the 6 months prior to inclusion in the study and receiving a first-line treatment approach containing PIs or NNRTIs plus 2 NRTIs were randomly assigned to 1 of the 2 following arms: abacavir/lamivudine/zidovudine fixed-dose combination (Trizivir; GlaxoSmithKline, Tres Cantos, Madrid, Spain, group 1) or lamivudine/zidovudine fixed-dose combination (Combivir; GlaxoSmithKline, Tres Cantos, Madrid, Spain) plus nevirapine (Boehringer Ingelheim, Sant Cugat, Barcelona, Spain, group 2). This trial was approved by the Ethics Committee of each center and was authorized by the Spanish Health Authorities.
The primary endpoint was the proportion of patients with plasma HIV-1 RNA <200 copies/mL at week 48 of follow-up. Secondary endpoints included the proportion of patients with plasma HIV-1 RNA <50 copies/mL at week 48, the evolution of CD4 counts, change of lipid metabolism and body shape, the safety profile of regimens, as well as patient quality of life, adherence, and satisfaction with the ongoing antiretroviral treatment.
We designed a noninferiority study to compare the triple-nucleoside arm with respect to the nevirapine-containing arm. The sample size was calculated assuming an equivalence range of 15% between groups in the percentage of patients with HIV1- RNA levels <200 copies/mL at week 48, with a statistical power of 80% and a 1-sided 0.025 significance level.
Baseline evaluation was used to collect sociodemographic characteristics and antiretroviral treatment history. At baseline and at subsequent visits (12, 24, 36, and 48 weeks of follow-up), plasma HIV-1 RNA, CD4 cell counts, lipid profile (under fasting conditions), anthropometrical measures, adherence to antiretroviral treatment, quality of life, and patient satisfaction with therapy were determined. Lipid abnormalities were defined according to each laboratory's upper limit of normality. The severity of adverse clinical events and laboratory abnormalities were evaluated according to the AIDS Clinical Trial Group toxicity grading scale.9 HIV-1 RNA was quantified using the NASBA assay (Organon Teknika, Barcelona, Spain) or Amplicor Roche Molecular Systems. Ultrasensitive HIV-1 RNA analysis (with a limit of detection of 50 copies/mL) was performed in all but 2 participating hospitals according to center availability.
Adherence to treatment was self-reported by patients and was considered appropriate if subjects assured that they had taken at least 95% of the prescribed doses during the previous 2 weeks. Quality of life was evaluated by the MOS-HIV questionnaire (Medical Outcome Study for HIV-positive patients). Effort to take medication was assessed with 10-point Likert scales.
The statistical analysis was performed according to a per-protocol (PP) and an intention-to-treat (ITT) analysis. Patients who were lost to follow-up or who withdrew their consent before the second visit (and consequently only performed the screening or the baseline visit) were excluded from the final analysis. Subjects who were lost to follow-up after the second visit or who discontinued the study regimen due to other reasons apart from virologic failure were censored from the PP analysis but were considered as treatment failures for the ITT analysis. The corresponding 95% CIs were calculated. Results were considered significant at P < 0.05. Multiple comparisons were adjusted by a least significant difference test.
Overall, 134 patients were included in the study, 68 being allocated to group 1 and 66 to group 2. Most of the patients were male (82%). Median age at baseline was 39 years in both groups, and baseline CD4 cell counts were (median, interquartile range [IQR]) as follows: in group 1, 530 cells/mL (396-858), and in group 2, 554 cells/mL (385-780). The two study groups were comparable at baseline regarding demographic characteristics and immunologic parameters. Up to 89% of the patients in group 1 and 94% of the subjects in group 2 were receiving PIs at inclusion in the study. Overall, the most frequent PIs were nelfinavir (35%), ritonavir-boosted indinavir (21.6%), and unboosted indinavir (17.2%). Most frequent NRTI strategies were: lamivudine + stavudine (45%) and zidovudine + lamivudine (20%). Five patients from group 1 and 3 patients from group 2 were lost to follow-up or withdrew their consent before the second control visit and were excluded from the final analysis (P = 0.74).
According to the ITT analysis, at the 48th week of follow-up, 71% of patients in group 1 and 73% of patients in group 2 had plasma HIV-1 RNA levels <200 copies/mL. Testing for differences between P1 − P2 = 0 yielded an estimate for the difference of −2.1% (95% CI: −17.4%-13.1%, P = 0.783) (PP, 98.6% in group 1 and 98.5% in group 2, estimate for difference: 0.04% [95% CI: −5.5%-5.6%, P = 0.988)]). In the ultrasensitive HIV-1 RNA ITT subanalysis (corresponding to 91.5% of the overall study sample), percentages of viral suppression <50 copies/mL at week 48 were 65.1% for group 1 and 63.2% for group 2 (estimate for difference: 0.010 [95% CI: −0.151-0.173, P = 0.897] [PP, 78.0% in group 1 and 73.4% in group 2, estimate for difference: 0.045, 95% CI: −0.123-0.214, P = 0.599]). Upon treatment analyses, median baseline values of CD4 cell counts were 492 cells/μL (IQR 396-792) in group 1 and 579 cells/μL in group 2 (IQR 426-846) (P > 0.05). A nonstatistically significant median CD4+ count increase from baseline of 96 cells/μL and 43 cells/μL was observed in groups 1 and 2, respectively.
One patient belonging to group 1 had early virologic failure at week 12 of follow-up. At his inclusion in the study, he was receiving didanosine/stavudine/ritonavir. Genotypic analysis at virologic failure showed mutations M184V and T215Y and the T69STG insertion. One patient from group 2 experienced confirmed virologic failure at week 48 of follow-up. His prior treatment included zidovudine/lamivudine/nelfinavir. Although his initial adherence was correct, it worsened during the study. Genotypic analysis at failure yielded mutations M41L, K101E, M184V, and G190A.
Thirteen and 14 patients, respectively, discontinued therapy due to toxicity. Eighty-seven percent of treatment discontinuations occurred within the first 12 weeks of therapy. The most frequent adverse event was rash in both groups (5 patients per group, respectively). Grade 3 or 4 toxicity was detected in only 1 patient from group 1 (anemia) and in 4 patients from group 2 (3 clinical hepatitis and 1 rash).
Median total cholesterol decreased from 5.5 mM (IQR: 4.1-6.2) at baseline to 4.75 mM (IQR: 4.0-5.3) at week 48 in group 1 (P = 0.018) and from 5.6 mM (IQR: 5.1-6.4) to 5.06 mM (IQR: 4.5-5.7) in group 2 (P = 0.03), respectively. Also, low-density (LDL) lipoprotein cholesterol ameliorated from 3.59 mM (IQR: 2.6-4.4) to 2.68 mM (IQR: 2.1-3.2) at week 48 (P < 0.001) in group 1; and from 3.6 mM (IQR: 2.9-4.2) to 3.11 mM (IQR: 2.5-3.6) at week 48 (P = 0.046) in group 2, respectively. The proportion of patients with hypercholesterolemia declined from 55.6% at baseline to 30.5% at week 48 in group 1 (P = 0.019) and from 68.9% to 42.2% in group 2 (P = 0.019). The proportion of patients with elevated LDL cholesterol decreased from 60% to 20.6% (P = 0.003) in group 1 and from 59.3% to 41.7% (P > 0.05) in group 2. All the variations in lipid profile were comparable between groups except for LDL cholesterol at week 48 (P = 0.049), with a more pronounced decrease in group 1. The subanalysis of patients who had prior exposure to PIs (92% of the patients included) showed similar results to the overall group. Overall, 47% of patients (31 patients from group 1 and 32 from group 2) presented lipodystrophy at baseline. No significant changes were demonstrated in body fat distribution throughout the study, and no new cases of lipodystrophy were detected.
Adherence remained high in both groups during the study follow-up (group 1-baseline: 94.3 ± 12.5, week 48: 96.7 ± 10.9, P = 0.87; and group 2-baseline: 97.3 ± 5.5, week 48: 97.6 ± 6.1, P = 0.79). Differences between baseline and week 48 were not significant in either group. Quality of life remained at adequate levels from baseline to week 48 according to the General Health Scale (group 1-baseline: 68.4, week 48: 67.5; and group 2-baseline: 67.1, week 48: 67.4). The effort to take medication decreased significantly regarding all the scales evaluated (P < 0.001). A more pronounced decrease in effort to take medication under was observed in group 1 at week 48 with regard to group 2 (P = 0.023).
This prospective, open-label, randomized, comparative, noninferiority trial shows that, in patients receiving successful PI- or NNRTI-containing first-line HAART combinations, treatment simplification with coformulated abacavir/lamivudine/zidovudine fixed-dose combination is not inferior to coformulated lamivudine/zidovudine plus nevirapine in terms of the maintenance of viral suppression <200 copies/mL for up to 1 year. Our study lacks the statistical potency necessary to yield definitive conclusions regarding the noninferiority of regimens according to ultrasensitive HIV-1 RNA measurements. However, results obtained by both conventional and ultrasensitive methods are consistent. In fact, only 1 patient per group experienced virologic rebound during the study. This study clarifies that an effective and safe simplification of standard HAART regimens can be achieved with coformulated triple-NRTIs if this approach specifically targets patients with a low likelihood of harboring nucleoside analogue-associated resistance mutations (NAMs). This includes previously antiretroviral-naive patients reaching a rapid, permanent, and durable suppression of plasma viral replication below detectable limits at the initiation of their first PI- or NNRTI-based HAART. Conversely, and according to prior studies,4,5 simplification with triple-NRTI combinations should not be attempted in patients with a history of suboptimal drug pressure or in those suspected of harboring NAMs for any reason. When most of our patients initiated antiretroviral therapy, pretreatment genotyping was not a standardized procedure in the clinical management of HIV-1-positive persons; therefore, these data are unavailable for this study. In patients with persistent viral suppression, assumptions regarding NRTI resistance can only be made based on clinical history because suppressed viral load precludes conventional resistance analyses. Our findings are concordant with previous studies suggesting that patients with a low probability of harboring NAMs or those without detectable NAMs are able to maintain long-term viral suppression with a triple-NRTI simplification regimen.3,6,7 Regarding the patient from group 2 who experienced treatment failure, it is likely that resistance mutations accumulated in stepwise fashion during the study due to suboptimal treatment compliance.
There were no differences in the proportion of adverse events between the study arms. The high frequency of treatment discontinuation due to adverse events in our study may be related to previous optimal tolerance to treatment of our patients. Notably, although the overall rate of treatment withdrawals for adverse events was elevated and presented a similar magnitude in both study arms, only 16% of adverse events seen in our study were in fact grade 3 or 4. In this context, any disturbance, even mild effects, as well the awareness of potentially dangerous effects, such as hypersensitivity reactions or hepatitis, probably induced physicians and patients to return to the previous well-tolerated strategy.
Lipid abnormalities improved early and in sustained fashion in both groups, in agreement with previous reports showing benefits of PI-sparing treatments on lipid metabolism.8,10 Improvements were comparable in the two arms with the exception of a more pronounced decline in LDL cholesterol in patients from group 1. This improvement is clinically important and implies a decrease in dietary restrictions, lipid-lowering agents, and probably in the overall cardiovascular risk of the patient. No remarkable changes in body fat maldistribution were found in this study. One partial explanation for the lack of improvement in lipodystrophy observed in our study is the perpetuation of mitochondrial toxicity through the continuation of NRTI exposure,10 although other factors, such as the lack of more sensitive measurements of lipodystrophy in our study (dual-energy x-ray absorptiometry or CT scan) cannot be discarded. Moreover, 48 weeks of follow-up may be insufficient to detect significant variation in body fat distribution.
In conclusion, patients receiving effective first-line PI- or NNRTI-based HAART can safely simplify therapy with coformulated zidovudine/lamivudine/abacavir or coformulated zidovudine/lamivudine plus nevirapine, as long as their likelihood of harboring NAMs is extremely low. Careful individual study of tolerance, treatment history, and baseline genotypic testing, when available, is crucial in determining the optimal simplification approach strategy. In a context of low likelihood of NAMs, the two strategies are similar in terms of virologic suppression, immunologic recovery, improvement of metabolic abnormalities, and the effort to take medication.
The members of the SimplifiHAART study group: A. Bonjoch, R. Paredes, J. Miranda, E. Martínez-López, J. A. Muñoz-Moreno, S. Gel, S. Videla, E. Masmitjà, N. Pérez-Alverez, B. Clotet, AIDS Care Unit, Lluite contra la SIDA Foundation, Germans Trias i Pujol Hospital, Universitat Autònoma de Barcelona, Barcelona; J. Gálvez, D. Morales, L. Orbea, J. Rodríguez, M. A. Muniain, A. Domínguez, M.J. Ríos, Servicio de Medicina Interna, Hospital Virgen de la Macarena, Sevilla; C. Miralles, J. De la Fuente, A. López, A. Ocampo, Y. Barbazán, C. González, Hospital Xeral de Vigo; J. de la Torre, J. L. Prada, A. Del Arco, Hospital Costa del Sol, Marbella; A. Prieto, E. Losada, Hospital Clínico Universitario, Santiago; C. Viladés, F. Vidal, J. Peraire, Hospital Juan XXIII, Universitat Rouira i Virgili, Tarragona; M. Márquez, J. Santos, J. Ruiz, M. González, Hospital Universitario, Málaga; A. Mariño, A. Fernández, Hospital Arquitecto Marcide, El Ferrol; D. Peña, M. Pérez, Hospital de la Línea de la Concepción; A. Masabeu, Hospital de Palamós; J. Pasquau, Hospital Universitario Virgen de la Nieves, Granada; M. Rubio, Hospital Universitari Arnau de Vilanova, Lleida; J. A. Terrón, Hospital General de Jerez; M. J. López, J. Corredoira, Hospital Xeral Calde, Lugo; and H. Knobel, A. González, A. Guelar, Hospital del Mar, Barcelona.
This article has been cited 10 time(s).
antiretroviral simplification; nevirapine; coformulated zidovudine/lamivudine/abacavir; coformulated zidovudine/lamivudine; HIV-1; noninferiority study
© 2005 Lippincott Williams & Wilkins, Inc.
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College Hockey:Union women's assistant Carpenito returns to alma mater as new Northeastern assistant
Northeastern announced the hiring Thursday of Nick Carpenito as an assistant women's coach.
A 2011 graduate of Northeastern, Carpenito returns to his alma mater after spending time on the coaching staffs at Elmira and Union.
"We would like to welcome Nick back to Huntington Avenue," Huskies' head coach David Flint said in a statement. "We had a lot of great candidates, but after the interview process, Nick's passion for coaching was clear and the only thing that exceeded it was his passion for Northeastern."
Carpenito was as an assistant coach at Union during the 2013-14 season where he oversaw the development and execution of practices and was heavily involved in recruiting, scouting, film study and travel coordination.
Prior to Union, Carpenito spent two years as a varsity assistant coach and head junior varsity coach at Elmira.
Carpenito worked and played with the Northeastern club hockey teams as an undergraduate student. He played for the NU men's team from 2008 to 2011 and simultaneously coached the women's club team, which won the 2011 ECWHL playoff championship and finished as the national runner up in Division I of the ACHA. Carpenito was named the ACHA Division I coach of the year in 2011 after previously being named a finalist for the award in 2009 and 2010.
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Crude Oil Still Might Rally
Rod David
Another warning shot across the bow has left no time for further delaying a valid rally leg.
The following are the latest daily summaries of my ongoing intraday coverage, providing context to interpret price action. Any prices listed are for a contract's current "front month." Their direction tends to correlate with any ETFs listed for each.
Today's Highlight:
If crude oil intends to rally, its delay in extending Wednesday's gap up now suggests a more aggressive beginning is needed to confirm.
Dollar Basket
Jun Contract DX; (NYSEARCA:UUP), (NYSEARCA:UDN)
Having held another day under the bounce limit, a retest of recent lows is still underway.
Jun Contract EC; (NYSEARCA:FXE)
Ranging narrowly Wednesday at or under 1.3110 only further suggests at least a blip-up to fresh highs is needed before reversing down. So, reversing down first would be premature.
Apr Contract GC; (NYSEARCA:GLD)
Tuesday's test of 1390.00 and 1393.50 may have chipped away at their support, but first they launched a bounce back up toward Monday's highs at 1410.00 that resolved down. Fresh highs would be credible for extending higher, while the next dip to 1390.00 and 1393.50 should be in the form of a plunge.
May Contract SI; (NYSEARCA:SLV)
Wednesday's gap up tried extending higher only to range sideways and close at session lows. Closing back under 22.35 would resume the decline next targeting 21.80 — actually, closing back under 22.35 should extend without delay to 21.80
30-year Treasury
Jun Contract US; (NYSEARCA:TLT)
Tuesday's testing of 140-05 was on the precipice of dropping, so Wednesday's gap up that extended higher helped to reassert that the pattern may be bottoming. Back above 141-12 would start to signal momentum reversing up.
Crude Oil
Apr Contract CL; (NYSEARCA:USO)
Wednesday's early surge to fresh highs was consolidated back down around Tuesday's 94.25 highs, but was otherwise maintained to put 96.00 into play, and probably also 98.10, so long as pullbacks now hold 93.45 as support.
Natural Gas
Apr Contract NG; (NYSEARCA:UNG), (NYSEARCA:UNL)
Ranging narrowly Wednesday ahead of Thursday's EIA report suggests only that the first trending attempted from the range is likely to be false. So, a fresh low that recovers back above 4.01 would be credible for launching a rally leg, but rallying first to 4.11 would more likely fail.
Editor's note: Rod's analytical techniques are designed to efficiently identify targets and turning points for any liquid stock or market in any time frame. He applies his techniques live intraday, primarily to S&P futures, at
RodDavid .com
No positions in stocks mentioned.
The information on this website solely reflects the analysis of or opinion about the performance of securities and financial markets by the writers whose articles appear on the site. The views expressed by the writers are not necessarily the views of Minyanville Media, Inc. or members of its management. Nothing contained on the website is intended to constitute a recommendation or advice addressed to an individual investor or category of investors to purchase, sell or hold any security, or to take any action with respect to the prospective movement of the securities markets or to solicit the purchase or sale of any security. Any investment decisions must be made by the reader either individually or in consultation with his or her investment professional. Minyanville writers and staff may trade or hold positions in securities that are discussed in articles appearing on the website. Writers of articles are required to disclose whether they have a position in any stock or fund discussed in an article, but are not permitted to disclose the size or direction of the position. Nothing on this website is intended to solicit business of any kind for a writer's business or fund. Minyanville management and staff as well as contributing writers will not respond to emails or other communications requesting investment advice.
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FIRST guest professor Ralph Williams enlightened an audience of Shakespearean aficionados with his talk on how Shakespeare used the sense of touch to convey a deeper meaning. For full audio of his presentation, hit play on the audio file below.
Join the English Department's Faculty in Residence Summer Term (FIRST) guest Ralph Williams for an illuminating discussion about Shakespeare's King Lear and The Tempest. Professor William is an award-winning faculty member from the University of Michigan. He is much loved by his students, and his presentation style promises to keep you engaged.
Reception 5 PM; Talk 5:30 • Wed June 18, 2014 • British Studies Room


text:
Focused Genetic Analyses Seek To Improve...
As Frequent Travelers Go, Viruses Are...
Opioid Epidemic Is Not the Only...
The Epigenetics Field Is Granular and...
Supelco will distribute MIP Technologies' analytical and preparative Molecularly Imprinted Polymer (MIP) separation products, under an exclusive global distribution agreement. The companies will also collaborate on the development of new products, while MIP Technologies will continue to separately develop its process-scale separations business.
These products contain MIP particles produced by MIP Technologies. MIPs are solid-phase polymer materials manufactured with specific affinity for single compounds or classes of compounds. Currently available MIP products include SPE cartridges for specific analysis of chloramphenicol, tobacco nitrosamine derivatives, triazines, clenbuterol, and other beta-agonists, beta-blockers, and beta-receptors.
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May 20, 2013 8:25 AM
Nuts for those nifty maps they use in the Indiana Jones flicks to detail our fedora-clad hero's international travels? Now you can have them on your fridge. The Mapnetic Magnet Set ($22) comes complete with dotted lines, dry-erase labels, and a handful of other goodies.... [More]
May 18, 2013 8:05 AM
The quickest way to brighten up an old room is to add some stylish wallpaper. Unfortunately for renters and commitmentphobes, though, the finality of traditional paper isn't usually the best option. Enter the Vintage Flower Removable Wallpaper ($25 per panel) from Chasing Paper. It's vibrant,... [More]
May 17, 2013 10:05 AM
We're about ninety-nine percent sure that the Beluga Bookends ($68) more closely resemble sperm whales. (Belugas are white!) But we get it. "Sperm Whale Bookends" definitely has a...well, a ring to it. And anyway, the bookends are pretty adorable as far as tchotchkes go, never... [More]
May 17, 2013 8:50 AM
Literary sorts, these Brackets Bookends ($45) by Design Atelier Article are definitely for you! Arrange your books between the mint-colored metal brackets so you always know what's on deck. They'll look smart while holding your library books or your favorite trilogies. You could also use... [More]
May 17, 2013 8:35 AM
So you love the scent of earthy, spicy black pepper, but you're less crazy about the sneezing fits it induces? Enjoy it without the phlegm with this Jonathan Adler candle ($38). You'll get the fab fragrance without the violent allergic reaction.... [More]
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May 17, 2013 8:05 AM
The quote on this cute and modern Ice Cream Print ($20) by Old English Company gives us total leave to devour a buttload of ice cream this summer. Unfortunately, it's our butts that will pay the price, so we guess we'll be practicing a bit... [More]
May 16, 2013 9:05 AM
Fancy scripted quote decals not your thing? You can still bring some easy brightness into your kitchen with these Grace Lee wall stickers ($50 for a set of five). Slap these sketchy drawings into the blank spaces above your countertops or let them adorn the... [More]
May 16, 2013 8:48 AM
You won't mind cluttering your fridge with notes and mementoes when they're held in place with these Qualy Hummingbird Message Magnets ($20). The colorful flock of tiny birds makes everything from wedding invitations to grocery coupons look pretty.... [More]
May 15, 2013 10:40 AM
You're probably thinking that you could easily DIY a pillowcase that looks a bit like someone used it for cleaning off their watercolor brushes. Go ahead and try. We're pretty sure you'll take a look at the splotchy outcome and break out the MasterCard for... [More]
May 15, 2013 9:55 AM
Think of the cash you can save on flower arrangements with this Five Hole Wall Vase ($30)! This simple, modern accessory turns a mere handful of buds into a stunning floral display. No more shelling out for big bouquets necessary - just pick up five... [More]
May 15, 2013 8:10 AM
Sticking photos into your bedroom mirror can be problematic - not to mention untidy! The Clipboard Mirror ($37) can hold pictures, mail, and reminders, making it perfect for keeping your life in order - as well your hair. (It is a mirror, after all!)... [More]
May 15, 2013 8:00 AM
Even though this Color Field Photo Print ($19-185) looks like a simple blending of colors, it's totally drawing us in. We think it's due in part to the Lisa Frank vibe it's giving off! But seriously, we're really digging that it's so cheerfully serene. Hang... [More]
May 14, 2013 9:06 AM
Real volcanoes smell like sulfur, and sulfur smells like rotten eggs. That's why we're glad that the perfumers of Capri Blue didn't feel the need to be literal when they crafted this Volcano Tin Candle ($15). Instead of stank, this piece burns with the scents... [More]
May 13, 2013 11:00 AM
We've been trying to declutter our homes, but it's hard - we just love our knickknacks. Luckily these Kalalou Ceramic Mermaid Bookends ($52) are utilitarian and pretty to look at, so we can justify them.... [More]
May 13, 2013 10:40 AM
Your bare-walled bedroom desperately needs some ink done! The Grand Royal Headboard removable decal ($78) is the perfect way for your wall to express itself - the illusion of elegance, at a fraction of the cost!... [More]
May 13, 2013 8:40 AM
Only in our dreams are we able to squeeze a Vegas vacation into our hectic lives right now, so we might as well settle in for a nap on this Catstudio Las Vegas Pillow ($158). It'll be money well-spent (at least opposed to a couple... [More]
May 13, 2013 8:15 AM
As any handbag designer will tell you, leather makes everything fancier. Coasters are no exception. Just take a peek at this Designer Coaster in Gold ($12). There's no more stylish way to sop up stray condensation.... [More]
May 11, 2013 8:10 AM
Is your home decor short on that all-important Alice in Wonderland vibe? Glam it up in psychedelic Victorian style with this Ceramic Tea Pot Spout Hook ($23).... [More]
May 10, 2013 8:15 AM
Want to fill your home with nice things you can't afford? Try tricking your senses with affordable decals like these Retro Phone stick-ons ($38)! You'll think there's an old rotary pay phone right on your wall so long as you don't look directly at it.... [More]
May 9, 2013 9:30 AM
We hate to ruin whatever spoon-bending dreams you might be harboring, but you're not actually living in the Matrix. If you feel like pretending, though, it couldn't hurt to make this Faceted Wall Clock ($80) part of your decor. With a shape that seems to... [More]
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Mead: More Budget Cuts NeededIn a budget session that is already going to be tight, Governor Mead now says further cuts will need to be made.
The state's revenue is largely based on minerals and the price of natural gas. When Mead submitted his budget proposal in December, the price of natural gas was $4. The latest revenue forecast now has that price around $3.25.
"I didn't spend all the money we had at $4." said Governor Mead. His budget had roughly $87 million left ofter. "But [that money] is gone. And now we have roughly about $50 million we have to find somewhere else based on $3.25 gas."
Mead says it could get worse with the potential of as much as a $2 reduction in natural gas prices from what was originally forecast.
Governor Mead and his staff are now in the process of submitting amendments to the joint appropriations committee for the budget.


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Despite both having exhausted their rookie eligibility during the season, Baseball America has named Washington Nationals second baseman Anthony Rendon and starting pitcher Taylor Jordan to its postseason 2013 Eastern League Top 20.
Obviously, both were key injury replacements for the "Big Nats," in 2013 with Rendon perhaps even displacing second baseman Danny Espinosa while Jordan is a strong candidate to return to the starting rotation next April, with the nos. 4 and 5 spots unsettled for 2014.
Long-term, BA believes No. 9 prospect Rendon's future could still be at 3B while scouts still
type one-handed marvel at the power:
Rendon has Gold Glove abilities at the hot corner and is more than capable at second base. Because of the vast strength in his wrists and forearms, he's also got the potential for more than 20 homers annually and a solid average.
No. 12 E.L. guy Taylor Jordan was given props for his pitching motion — which is often compared to Angels ace Jered Weaver:
Jordan employs a sneaky delivery that includes long arm action and a stab on the back end. That deception helps his arsenal, [which] includes a low-90s heater with plenty of run, as well as a slider and a changeup, play up.
All total, eight Nationals were named in these top 20 lists, though no prospects were named at the Low-A and AAA levels. Last year, that figure was five, with Brian Goodwin named to the Top 20 of both the Sally League and the Eastern League.
11 Responses to "Rendon, Jordan Named To BA's Eastern League Top 20"
I didn't know the criteria for these Top 20's, but Rendon officially no longer qualifies for prospect status. Not so sure on Jordan or Roark.
Still amazing that Harrisburg made EL
Finals with Matt Skole on DL!!
If Davey were still managing I have a sneaking hunch Skole would have ended up on his bench.
Now, I think they'll go back to being more traditional about developing and promoting prospects. Making them graduate from every level as Rizzo once said.
Where's karns at screwed again I see!!
We all know Karns value will spell out
With nasty stuff out of Nats bullpen in not so
Distant future
I do not have the Top 20 in front of me but
With Philly, Mets and Yanx in same league
They ate up some numbers too.
Taylor was just filthy sick.
Nats fans , did we not laugh at Braves using
Freddie Garcia when next year TJ is in the
Mix with Dorf and Herr Detweiler while BrAves
May retain Hudson.. Hmmmm
Repeating is a b—-
I hope he's traded before that happens the nationals never gave him a chance like they TJ and Roark..
Karns was the first call-up so I have a hard time seeing how he didn't get his chance. he'll go to Syracuse (hopefully Jordan does too) and I'm sure he'll make the MLB roster if he has success there.
Three starts isn't a chance a your debut start against the orioles which had the best offense in baseball at that time..TJ didn't face a good team until his ninth start and Atlanta had a ton of injuries at that time and he still had a era of 4.
And karns led or was in top five in every category! Lead era in my opinion led in strikeouts.


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The TUDOR United SportsCar Championship (USCC) 2014 inaugural season will feature some familiar faces, as Chip Ganassi Racing with Felix Sabates will bring its powerhouse teams from the Grand-Am ROLEX Sports Car Series into the new league formed by the merger of Grand-Am ROLEX Sports Car Series and American Le Mans Series. Drivers Scott Pruett and Memo Rojas, who together won the final four Grand-Am ROLEX driver and team championships, will again combine forces with the goal of a fifth straight championship overall and first-ever USCC championship.
The season's inaugural race, the ROLEX 24 at Daytona to be held at Daytona International Speedway on January 25 and 26, 2014, will have two Ganassi entries. The ROLEX 24 at Daytona has often been considered something of an unofficial start to the NASCAR season, as each year several Sprint Cup regulars have entered the race for various teams. Ganassi has tapped his two NASCAR Sprint Cup drivers Jamie McMurray and Kyle Larson for this year's event, with McMurray joining Pruett, Rojas and 2013 Indy Lights champion Sage Karam to drive the #01 car while Larson will join forces with Ganassi IndyCar drivers Scott Pruett and Tony Kaanan along with Marino Franchitti, younger brother of recently retired Dario Franchitti, to pilot the #02. The #01 will carry sponsorship by Mexican telecommunications company Telcel along with Target Stores and hi-tech pillow manufacturer Comfort Revolution. The #02 has sponsorship from Target Stores along with Telcel and Big Machine Records, a country music label whose artists include Taylor Swift, Rascal Flatts and Tim McGraw. Both cars will be Fords, using its 3.5-liter V6 EcoBoost racing engine for this and all other races during the 2014 USCC season. Ganassi's NASCAR and IndyCar teams are Chevrolet.
Together, the drivers Ganassi is deploying for the 2014 ROLEX 24 at Daytona have won twenty-three series championships, two Indianapolis 500s, one Daytona 500, one Brickyard 400 and four Rookie of the Year awards.
With a single sports car series, and racing heavyweights such as Ganassi bringing their full arsenal to the new league, racing aficionados are rightfully hopeful the sport can now focus on broadening its appeal to both stock car and open-wheel racing fans with its blend of the best of both worlds.


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Sept. 17, 2005
Final Stats | Quotes | Notes | Photo Gallery
STANFORD, Calif. (AP) - Jon Grant threw a 3-yard touchdown pass to Blaise Smith with 8 seconds left Saturday night and UC Davis stunned Stanford 20-17 to spoil coach Walt Harris' home debut for the Cardinal.
The Aggies (1-2), who are in the third year of a four-year transition from Division II to Division I-AA, were not intimidated by the Pac-10 environment, keeping Stanford's offense out of the end zone all game and allowing just 180 yards for the night.
"The bottom line when you lose, you lose," Harris said. "It doesn't matter if it's Davis or USC. When you play like that, you will lose every game."
After T.C. Ostrander's last-ditch pass fell incomplete at the 5, the Aggies celebrated in the end zone while Harris walked off the field with his team. The Aggies then ran to the corner of the stadium to thank the thousands of fans who made the two-hour trip from Davis for the game.
"When they announced the schedule our fans were really excited and got together and bought tickets," UC Davis defensive line coach Fred Arp said. "I've been here 39 years and nothing compares."
The Aggies mounted the winning drive after Emmanuel Benjamin missed two field goals earlier in the fourth quarter that could have tied the game at 17. They took over at their 28 with 2:37 to play. Grant threw a 12-yard pass to Brandon Rice and a 17-yarder to Smith to get the drive started.
Then on a third-and-4 from the Stanford 25, Grant hit a wide-open Tony Kays for 19 yards over the middle for a first down. After a 3-yard keeper and an incomplete pass, Grant found Smith open in the front corner of the end zone to cap the 11-play drive.
"We always felt confident," Smith said. "I don't know what they said at halftime, but we just saw that small opening and it was enough. ... I knew if we got the ball back in our desperation offense, we could make the plays. It seemed like we always do."
Grant finished 23-for-44 for 251 yards and also ran for 41 yards. Nelson Doris ran for two scores and Kays caught 10 passes for 115 yards.
Stanford quarterback Trent Edwards left the game after two series with an undisclosed injury and was replaced by Ostrander. Both Stanford touchdowns came on fumble recoveries in the first half. Ostrander was 7-for-17 for 108 yards.
"It's hard to pinpoint one thing," Ostrander said. "Collectively on offense we didn't get the job done. I was extremely disappointed in how I played."
Turnovers played a key role in the scoring, with Stanford scoring twice on fumble recoveries in and UC Davis' first two touchdowns coming after Stanford fumbles.
With the Cardinal leading 3-0, Ostrander drove his team down the field on his first drive before being intercepted at the 1 by Adam Cook. But on the next play, Kevin Schimmelmann sacked Grant in the end zone, knocked the ball loose and fell on it for a score that made it 10-0 late in the first quarter.
Stanford's second defensive score came midway through the second quarter when Babatunde Oshinowo stripped Doris of the ball and Michael Craven scooped the ball up and ran it back 54 yards to make it 17-0.
UC Davis had to punt on its next drive and David Marrero tried to field it inside his 5, muffed a fair catch attempt and Cook recovered for the Aggies at the 3. Doris ran it in on the next play to make it 17-7 at the half.
The Aggies struck quickly in the second half after Luis Amaral ripped the ball away from Anthony Kimble and recovered at the Stanford 41. That set up a 1-yard score by Doris that made it 17-14.


text:
The Genealogy of Jeremiah Holloway and Myra Adderley
Marianne Holloway McCalip
I help give a voice to those that can no longer tell their own story. I research your family history and then write about their journey from where they came, how they got there, who they were and what they did. Let me help you discover your family's story.
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8 comments
yup LUKE...FRIGGIN...SKYWALKER
Oct 14th
michael vox has a generation i luv him
August 15th
August 13th
Ryan has a wife? How?
August 12th
Oh, Hannibal FELT the force.
August 12th
Also kinda looks like Mr Hannible was tickling Alice.
August 12th
August 12th
Feel the force, Luke.
August 12th


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Earlier NFL draft-related questions this week centered on finding the heir apparent for Drew Brees, seeking another scat back, the need for a first-round wideout, and finding a Jimmy Graham 2.0.
But none of those address an essential area: Protecting No. 9.
He's the franchise. Without him, the New Orleans Saints don't win.
To find players whose job to keep Brees upright makes sense.
Our Larry Holder said to watch for the Saints to use mid- to late-round picks on offensive linemen, but depth issues in the interior line could create additional urgency.
Especially at center. Tim Lelito has so little experience at that position that the Saints website lists him as a guard.
The experts at cbssports.com figure most drafted centers to go on Day 3. The guard position, however, might yield more higher-round prospects worth considering.
What do you think? Is there an offensive line prospect you'd like the Saints to snag? Should the primary focus be to find more adequate protection for Brees? Or are there other needs to address?
Share your opinion in the comment section below this post.


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Sony marketing vice president John Koller said that the PlayStation 4 sales figures released this week is more about the company continuing to achieve the goal of growing its install base rather than one-upping Microsoft and the Xbox One, according to a report today from GameSpot.
Sony announced it had sold-through 4.2 million PS4 units in 2013 during International CES this week, a day after Microsoft revealed it pushed out 3 million Xbox One units. You can read that full Examiner report by clicking here.
Koller, in an interview with Computer and Video Games, said the recent sales figures in which Sony outpaced Microsoft in next-gen console sales before the New Year, doesn't really matter a whole lot.
"We look at it really just introspectively," Koller said. "The '4.2 million' number is important because it gets us further toward our goal. And that goal is the largest install base we can possibly get –– to encourage publishers and developers to continue to make great game experiences for PS4."
Sony Corp. CEO and president Kazuo Hirai championed a similar sentiment in an interview with BBC Breakfast today, downplaying the company's accomplishment in the console gaming arena.
"I've always said that a console business is a five to 10 year proposition," Hirai said.


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Let me be blunt for a moment. The reason I succeed is because most of my competitors are simply failures. In the online search engine world, I am fighting for the top 10 positions for my keywords. My competition sucks, badly. For my clients their competition is even worst.
Seriously how weak is your marketing efforts? Are you at like less than 5% conversion rate, or even less than 1%? Hell, are you even tracking conversions? Do you know what a conversion is? (Amount of traffic that converts into a leads or sale)
Failure I believe derives from Fear. Most people are simply scared to get a website and put their hard earned money into their sites. The Internet is still to magically of a place. That's why when a client of mine spends 30K to 60K with me a year, they not only receive great results, but get usually an 4 to 8 month return on investment. Then next year I double their budget, since by then they have more than tripled their online revenue.
There have been times, which I live for by the way, where I have gone up against, head to head, with another online marketing that knew what they were doing. They are smart enough to understand the techniques like dynamic SEO. I see their titles, header, and Meta tags changing at a rate that would make most people dizzy and throw up. Those are the rare challenges that I live for, but for the most part my daily journey through the Internet is a joke when looking at it from an online marketing perspective.
There are website still keyword stuffing, and relying on Meta keywords to increase traffic… and guess what they are getting the traffic!! Cause there is almost no competition in their industry! None!
I am going to be more brutal with the next paragraphs, so for the squeamish exit stage left.
Fact is people have read everywhere in the online world, in order to success you need content. Content is King; Traffic is Supreme, as a version of the saying goes. So what do most website owners do, they put up weak duplicated content and hope for the best. They don't take the time to work with a copywriter to create new daily or weekly content. Then they wonder why they are still not ranking high for their targeted keywords. Give me a break. When I see thing in an industry I am entering, forget about it, it's over. 2 to 3 articles a week of writing and syndication, without doing nothing else to a client's website results in a complete take over of the top 10 positions of the website within 3 months. But Adelard, how can you take over 6 or more positions, when the search engines allow only a max of 2 positions rankings for each site… Elementary, Syndication. I get my articles on authority websites as well as my own, AND here is tip #1, ALWAYS link back to your original article on your website. There you have it, duplicate content problem solved, and by the way, you just took over more than several top positions for targeted keywords.
A/B Split testing
People have also heard o something called TESTING… Yes that's right, A/B Split testing, multi-variant test, test, test, and always be testing. I mean for goodness sakes, how can any web developer get it right the first time out of the gate? Impossible, even if they know that niche inside and out. Every website and domain is different. Test the colors, test the buttons, test the layout, and continue testing. Google even has a Website Optimizer that allows you to test; they make it so simply. Why aren't you testing everything? How else are you going to increase your conversion rate? How else are you going to know that this version is the best possible version of the web page? I test everything, down to the damn font type.
Analyze Stats
Analyze and understand your stats. Do you know how to improve the bounce rate? Do you know what a bounce rate is? Bounce rate is the amount of people going to your website and immediately leaving without visiting another page. How high is yours? How do you reduce a bounce rate? Easy, test for it. Remove garbage that is not working, and focus on bettering user experience. Honestly if have a website with an overall bounce rate over 40%, your website sucks! View your stats and find out which individual web pages have the highest bounce rates, and improve them. Add better content, here's a great tip, ADD PHOTOS. Simply adding an interesting photo to a page will increase the time on page for that page, and help reduce your bounce rate. Add a freaking video if necessary. Hell if you simple don't know why people think your website sucks, ASK THEM! There are customer surveys and feedback solutions that will allow you to directly communicate with your website visitors and get ideas on why your website sucks!
W3 Validation
Here is another tips, W3 validate your website. W3 validating your site makes sure that no matter what browser or operating system a visitor is using, your website will appear exactly right on it! Look at the numbers, you gain more ground with being w3 compliant than if your website was made for a weak browser such as Internet Explorer. And seriously why are you still using Internet Explorer? Do you like viruses? And please, testing your website in other browsers when designing and adding new code, you will be surprised at the glitches that can occur and can be easily fixed by simply testing them. Jeez!
Expand Your Presence
I know I shouldn't let this one out of the bag, but you have to also be everywhere. I mean jump on Facebook and link back to your site, get a Myspace, Twitter, Digg, Reddit, Youtube channel, Merchant Circle, be freaking everywhere. If you are not, when one of your competitors hires me, trust me, I will be everywhere you are and especially where you are NOT! Join forums, networking websites, and industry portals, not only is this going to increase your presences, but will allow you to increase traffic to your website, AND increase leads and sales since more customers will be able to find you!!! Drop links everywhere you can. Getting exposure is easy, I once created a robot to login to random chat rooms where people where talking about my niche, and had the robot say my url every 30 seconds or minute or so. I got traffic, I got leads, I got sales, and sometimes I got booted or banned. But I got mine! Also, by expanding your presence, you rely less on one source of traffic, let's say a particular big search engine, and can afford to take a hit now and then as the major search engine adjust their algorithms, or you test out a particular layout that might temporarily drop you.
Spy On The Competition
I mean seriously, Google makes it almost child's play to spy on your competition. Do Google Alerts on all your competition's websites, brand names, and your industry topics. Every time something happens, be there, if it is a blog, response on that blog in the comments and backlink your website! Drop links wherever your competition drops links. Look up all their backlinks using yahoo site explorer, download the CSV file that yahoo makes it so easy to download your competition's backlinks, and run through that list for a certain time. Since the limit is the first 1000 backlinks that you can download, divide that up into 33 backlinks a day over the course of a month, and bam, when you move onto the next competitor, you will start rising faster and faster in the search engine rankings and will soon become an authority level!
Spying on your competition works, for example I got former employers and competitors all over my websites trying to figure out my tips and tricks and how I get the results I get. I know, cause I have all their IPs, I know exactly what areas of the website they visit, how long they stayed on, and what topics they read. To try and hide, they even use proxy.org to view my site. Losers. Since I'm a mad scientist I have created some advanced tricky programming scripts to allow me to take what Google Analytics does and multiply it by 1000%. I've seen examples of where the weak competition comes to my website, reads an article about Viral marketing, and bam in one day they have an article about viral marketing saying the exact same thing I said using my buzz words. I laugh, cause they got no originality. I mean, come on, coming to my site, to get ideas for your blogs and article topics, that's weak, I talking to you o7. WEAK. But hey what can I do, except continue leading the pack.
Seriously, for anyone that wants to get top rankings and dominate their niche, hit me up, I'll show you how to do this. For everyone else, I'll see you on the playing field where you will be simply a pawn, like o7 IS. Jeez and stop keyword stuffing people!!!
Finding a great SEO expert is very hard to do if you don't know what to look for. With the thousands of online marketing websites, and search engine optimization firms all saying they are #1, it can be overwhelming to find the true professionals. In order to find the best SEO experts for my clients I look at a company according to their portfolio, their results, their knowledge, their marketing strategy, and their organization & management abilities.
A quick look at their portfolios should show give you a great indication of whether they are professional or not. If they have worked with big companies and small companies that's a good sign that they have scaling abilities.
Results are the only things that matter in the end. Can they get results? Can they show you results that they have gotten for their clients? Do they have a case study and references that you can talk to?
Is their presentation of their own website clean and efficient? Can you navigate their website and find quickly ways to contact them? Does their presentation give a custom, high quality, and at the same time a creative feel?
Do they have knowledge and understand of their industry? A good Internet marketing company will have a knowledge center that will help educate consumers and clients. Do they offer a free services like a free website analysis for customers so they can understand better their current rankings? Do they possess a willing to teach and learn at the same time? It is important to learn about a new industry and the players in the marketing in order to get a better grasp and understanding of how a successful Internet marketing campaign can be launched.
Do they provide a clear strategy and outline of how they are going to launch a successful Internet marketing campaign for you as a client? Are there clear goals set for their clients?
Are they organized and how is their management abilities? Do they have a centralized location for information and a customer login system where clients can see what is going on with their project and communicate efficiently with the team?
Karma Snack is a unique company that has risen quickly in the SEO world. Karma Snack provides clients with everything that they need in order to gain great search engine rankings, increase in traffic, and increase in sales.
Karma Snack is one company who's staff has worked with Fortune 500 companies like American Express, Chase, Ingram Micro, Dole, Wachovia, Bank of America, Citigroup, Toshiba, Formula 1 & 2, Porsche Racing, 99 Jamz of South Florida, AOL, Quigo, Google, Yahoo, MSN, Nike, Apple, Iphone Dev Team, and more. The have also help develop from start KO Dynasty, the fastest growing MMA Sports management company, and A2z Big Loans, an international commercial loan provider.
Karma snack has proven results with over 2,000 first page search engine lists and a $5 billion case study of one of their clients. They also provide references upon request to current clients so you can talk to in order to get a feel for what it is like to work with them.
Karma Snack has web developers with over 30 years of experience combined in online web design and Internet marketing. Search Engine optimization is a specialty for Karma Snack, and it is one of the reasons it stands out amongst the competition.
Karma Snack has an in-depth and growing knowledge center that hold an expert advise in Internet marketing and search engine optimization. A newsletter signup is also available for customers who want to get updates on new information and services. Karma Snack also offers a free website analysis for visitors to get an in-depth understanding of their current rankings and how they can better their search engine marketing campaigns. Karma Snack's goal is to teach and education consumers on how to increase rankings and gain targeted traffic to their websites.
Karma Snack provides a clear strategy and outline of all Internet marketing campaigns to clients. They also help education clients on how to better their other marketing efforts and help sync offline with online marketing campaigns. Each client is at a different level, but the goals of Karma Snack stay the same: Increase Traffic, Increase Leads/Sales, and then eliminate non-performing marketing efforts.
Karma Snack has a unique project management system that they provide their clients access to in order to view their current marketing project, see what is scheduled. The Snack Board (project management system) allows Karma Snack a centralized location for communication with their in-house staff and clients. Clients and members of the staff can be anywhere in the world and still be able to access the Snack Board and view what is going on, and what the next milestones and goals are for a project.
Karma Snack has set themselves as one of the top Internet marketing companies in the world, and has proven to my clients and me time and time again that they are #1. They focus on quality and results, that's the only thing that matters at the end of the day.
Does your web traffic lack the great "flow" that was promised to you by your SEO company?
Does your SEO company suck? Do you needs to find web traffic experts that can deliver results, hold you to no contract, give you monthly reporting, and have client testimonials to back everything up?
I can continue with the frustration stories I hear day in and day out. "The guys who I'm working with promised me this and that, and haven't been able to deliver". I also hear lately, "I don't have money to market". Well the latter is a big problem, since no respectable serious internet marketing is going to work for free.
The facts are facts, when it comes down to getting your business in front of your target audience, internet marketing is hands down the cheapest, and most measurable media.
There are a lot of "guru" and "web traffic experts" who give the professionals in the industry a black eye. As an internet marketer, there is a constant needs to show results, proven case studies, client testimonials, etc. Even then, there is still a risk.
Whenever you hear something too good to be true, it usually it. If a company can promise you to get top rankings in your competitive industry, for famous one word keywords for as little at $199 a month, chances are, you are wasting your time and money.
There are several of these $199 a month SEO companies out there that take client's money, promise the world, and then 6 months later leave their clients with a bad taste in their month.
It comes down to the basic, what we all were taught growing up, "You get what you pay for" and "There are no Free Lunches".
When it comes to Internet Marketing a decent campaign cost can range from $12,000 a year, to $100,000 a year. These are with reputable companies, that have great client retention, customer testimonial, AND in my opinion most important take the time to teach each client the fundamentals of internet marketing.
Compare that with an advertising spot on a magazine that ranges from 2K to 100K per AD, once the magazine's month is done, you don't reap the rewards of it. How do you measure how many people saw your Ad? You can't. How can you measure how many people understood your TV commercial? You can't. How do you measure how many people heard your radio spot? You don't.
With the advent of the internet, new ways of measuring how your audience responds to a marketing campaign are now possible. For example, you can measure how many people saw your ad, went your website, saw a particular images, what percentage of them converted into a sales/leads (conversion rate), and more.
With internet marketing you can test different marketing messages and measure which ones directly leads to increased sales, increase leads, and increased time spent on your website.
What I love about internet marketing is that is brings accountability back into dollars spent. With data, you can justify spending X amount of dollars, and with internet marketing, you can now know exactly on a click by click basis, what marketing campaign dollar lead to your sale, and the exact cost of acquiring new revenue.
This is what newspapers, magazine, TV, radio, outdoor billboards, and other traditional media don't have. This is why they are declining, and more major companies are spending money online. Web Marketing's ROI is the most accurate when compared to other medias, and guess what? It cost a lot less.
To get free advice, or learn more about finding a great SEO company, simply Google "Karma Snack". This is the company that has been the most successful when it comes down to ROI, expertise, and getting results for my clients and me. I am now intricately involved in the company, it's growth, and it's future. We deliver results. Period. Ff you don't see significant results within your first year, Your next Year is on us! That's right complete FREE!!!


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Programming Microsoft ASP.NET 4 is a well-written guide to the architecture and implementation of Microsoft's ASP.NET platform. It would be most useful to experienced ASP.NET developers as it does not cover the basics of ASP.NET, and does require the use of a modern Microsoft operating system (Windows 7, etc) to perform any "hands on" activities.
Developers who are currently using "classic" ASP.NET techniques may wish to read this book for a view of at least one view of the platform's future, that is a movement away from forms and toward model-view-controller (MVC). The author lays out his reasoning in a logical manner and explores the justifications as to why Web Forms, while not quite dead yet, may not be the foundation you should choose for your next project.
For those who are happy with Forms/classic, the book still provides good, in-depth walkthroughs of the anatomy and function of ASP.NET. Architects would probably find this a must-read, and it could be useful to technical project managers who deal with Microsoft platforms.
Dino Esposito is, as usual, an engaging author who has a knack of making this material, which can admittedly be dry, into an enjoyable read. I have several of his earlier works and usually retain them as reference materials after the first read; this book should follow that pattern as well.


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The intro to my column says the finer and not-so-finer points of Raid Leading. Today it's time to get into one of those not-so-finer points. For every successful raid in an established guild there are many people in the background doing the work that no one else wants to do. There is this thing called paperwork and it is something that can be simply horrible. If you are the main officer or raid leader the sad thing is you are probably going to be the one doing a lot of it. What kind of paperwork am I talking about? Let's find out.
Back in the day (which means before I had two kids and my job let me surf all the time at work) I did a lot of paperwork getting our raid setup for WotLK. In fact I pretty much did everything, then I slowly handed off things to people to do. Now I can say a bunch of angry drunk officers do all of the work without me. I actually feel pretty bad for them because this stuff stinks on ice, but it is a requirement for any well oiled raid to have a good documentation, scheduling, recruiting, and promotion system. Let's jump right away into the kind of torture you might find yourself dealing with. Note that some of these are repeats from earlier Raid 101 columns, but need to be included in paperwork.
First rule of paperwork
Don't stab yourself in the eyes when you feel like it, you'll miss your vision.
Second Rule of paperwork
When you feel like the above it's time to get more people involved because misery loves company.
Have you ever wanted to find a way to please no one all of the time? Start with trying to make a raiding schedule. There are always people who can never raid with the schedule you put up (be it classes that run into the raid start time or a million other reasons) and thus causing the gnawing and gnashing of teeth. The truth is that raiders will adapt to any schedule you put up, even ones that don't make any sense at all. However do yourself a favor and try to make some sense.
Things to think about with Scheduling:
- First find the days most of your core raiders can make it.
- Scheduling for yourself is great, but not if you are the only one to show up.
- Talk to all officers and raid leaders in your time frame on when they can make it.
- Talk to the GL to make sure there aren't any limits on your ability to schedule the raid time as you see fit.
- Unless you feel like just doing it and hoping you aren't removed from the guild for raiding Throne of the Four Winds on the third Sabbath of the Month.
- Try to make two raids if you have enough people so more people get a chance to run, this will help your raid grow.
- If there is more than one place you can raid during a week set them as different raids.
- If there is a raid that is easy and people may PuG a lot such as BH then do that right away Tuesday night so people get the rest of the week to try and PuG that raid.
- Unless you like failing to get a raid up and running, in that case schedule it for Monday and make people sign up the Monday before.
- Try to always leave one day off a week for random things like PuGs and such, Monday works great for this because everyone is trying to get those Arena matches and BH PuG runs in before the maintenance window and raid resets on Tuesday.
- Don't constantly switch the schedule up, people will get used to it and start planning for it.
- Change the schedule when the current tier level gets easy or another one is added.
- Naxx became almost a one day run before Ulduar hit.
Example of scheduling
This was our schedule while learning the raids. We started with Tuesday because that is maintenance day.
Note: BH is Baradin Hold, BoT is Bastion of Twilight, BWD is Black Wing Decent. You may want to only have one two day raid a week that is fine. We're now at the point where we get to Nef or Cho'gall almost always the first night.
- BH if available.
- Throne of the four winds.
- Check BH again to see if it is available.
Wednesday - Friday
- Progression raiding: BoT or BWD switched every week.
- Friday usually ends up with alting people to try and get a kill group because Nef or Cho'gall are the only bosses left standing.
- Farm raiding: BoT or BWD switched every week.
- Mostly just want to kill every boss and hopefully get a few attempts in on Nef or Cho'gall.
- Free day to rest up and do all those other things you want to be doing instead of raiding.
If writing the schedule didn't make your brain bleed then the posting it will surely cause mind melting. At Malice we use guild forums so new forum posts have to constantly be created, filled out, then moved to a completed raid forums for every raid every week for two time slots. At one point I was doing all the posting for both Early and Late raid scheduling AND moving the completed raids out to the completed areas. Be sure you lock things until a week out because a lot of people who sign up two weeks in advance tend to forget they signed up at all. You can avoid this type of paperwork by using various addons or the Blizzard in game calender. Different guilds have different sizes and styles and finding whatever the most efficient system can help ease the paperwork pain.
We've talked about rosters before and this is probably the oddest of all paperwork. It can be fun because it's like a puzzle you have to figure out and you feel good when a group you put together wins. However it can be horribly bad when not enough people sign up or too many sign up (meaning you have to alt nine people because there was just a few raiders short of a second group).
Things to think about for Rosters:
- Breathe. Passing out because you hyperventilate over not having enough healers helps no one.
- Try and remember if anyone usually signs up and didn't
- I've texted people who are currently in game to ask other people to sign up.
- I've also texted people directly to ask if they are signing up.
- With the new mobile app being released soon you can hit up your guild chat and guild rosters list directly from your smartphone.
- It almost never comes out like you plan.
- People don't always show up and it repeatedly makes my face make contact against my desk at a very fast speed.
- Have a method to the way you alt people.
- You will hurt people's feelings and they will come crying to you asking why you alted them.
- Telling them that you went alphabetically is still better than saying you just 'felt like it,' which translates in Drama Monkey lingo as "I HATE YOU AND YOU WILL NEVER RAID IN MY RAID AGAIN! P.S. YOU FAIL AT LIFE TOO! p.p.s your shoe is untied"
- Make sure you alt yourself sometimes too.
- Everyone gets alted sometimes so it is up to you to live that message.
- Besides you might suck so bad that your raiders need a break from you.
- Have more than one person doing them!
- I used to always do all of them and it just gets old after a while.
- Having more than one person means less burn out.
- It can also combat the favoritism QQ you might get.
If your guild uses an attendance system for anything like rank promotion points or DKP you will need to take attendance.
- Have the raid leader take a screenshot of the raid frames at raid start and end.
- Make sure you post any information that the guild needs.
- Stating Mervin the Magical Mage raided means nothing if the person in charge of tallying points or attendance has no idea when you ran and what you ran.
- Make sure to include dates and times as well as what you can.
- Make sure it's posted right away.
- Saying you'll remember tomorrow usually means you already forgot what you were supposed to be doing and decided to check out the dancing blood elf on the mailbox.
- Make sure to note if someone only raided one day.
- Even if it is not required by the guild it is good to know who you can count on to be there the entire raid.
New people to the guild will go and check out your strategy section to get up to speed with how the guild does certain bosses, so don't forget to update it. Use your super spider sense to seek out officers (or just regular members) that love this kind of work. Handing over a mundane task to someone who makes it a labor of love helps everyone.
- Any changes to strategies should be posted out in the guild forums.
- Make sure you include 10 or 25 man and why you change to a certain strategy.
- Have your own kill videos if you can present to help them see how you kill certain bosses.
- Someone has to post the original strategy which requires a lot of formatting.
- Sometimes people just link the kill video from another site such as Tankspot and then write down in a reply anything the guild does different.
- Someone needs to move these or delete these when a new expansion comes out.
Officer Discussion Area
Make sure you put a giant thread (if you use forums) or some other documentation discussing three things;
- Who was causing trouble in raids.
- Who was helping a lot in raids.
- Any issues not related to raiders, but the raid.
Someone needs to keep track of if - there are people who may end up being one of your raid leaders some day. You need to keep a list of good and bad people so when they come back crying and all butt-hurt because they got alted two weeks in a row you can look up and say, "Well you were being a big drunk douche the other week so we decided to let you cool off for a couple weeks. Got a problem with it?"
Number three is basically if the raid leaders or the officers in the raid noticed something, (accidental or otherwise) for example did looter loot get messed up, did certain class combos work out for an encounter, etc. It is a good thing to have a place where personnel can put if they can't show up for a night, or if they accidentally alted someone twice, or they let an alt take loot, but didn't realize it and they are sorry, etc.
Paperwork is the oil that keeps a raid moving smoothly. If no one can ever get promoted or finds out why they got alted they may just stop raiding all together. Paperwork keeps you informed on issues during raids you can't attend, how raiders are doing, who is active and who isn't, and most of all proves that people are showing up and work is being done. Paperwork is also written in the blood of your real life. Say goodbye to an hour or so extra of your day just to do rosters or 20 minutes after a raid to write down all attendance and anything other officers should know about. If you like whips and chains being used on you then you'll love paperwork. If you like to inflict pain on your minions then delegate it to everyone else and go get a drink because you deserve it for being so damn cruel. Oh and if you must, just promote someone to do the paperwork and then demote everyone else who doesn't raid lead and didn't want to do paperwork. They don't have the pain tolerance for raid leading in your raid anyways.
< Last Week - Know Your Role | Series Start |
Gordrin is the current Raid Leader of Guild Malice - Early Raid. In addition to being talented at tanking, Gordrin is also an accomplished lutenist. Gordrin can be reached at email@example.com


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The day of your child's transplant is called Day 0. Your child will get the new blood stem cells through the central venous line (CVL). Here is how your child will get his treatment:
Engraftment is the when healthy donor cells begin to grow. It usually happens about 10 to 28 days after the BMT.
There are three ways to collect healthy blood or bone marrow, called a graft, for BMT:
Bone Marrow
For a bone marrow collection, blood stem cells are most often collected from bone marrow in the hip bone. The hip bone has a large amount of bone marrow and is easy to get. The collection is done in the operating room while the donor is under general anesthesia.
The total amount of cells removed depends on the weight of your child and the weight of the donor. The bone marrow collection takes about one hour.
Peripheral Blood Stem Cell Collection
Blood moving through the bloodstream is called peripheral blood. Blood stem cells can be removed from the peripheral blood. The donor may receive a medicine called a growth factor (GCSF or GMCSF). This medicine helps the bone marrow make a lot of new blood stem cells quickly and pushes them into the bloodstream.
The blood stem cells are collected through a large I.V. in the arm or central venous line (CVL) into a machine, called an apheresis machine, and returns other important cells (red blood cells, white blood cells, platelets and plasma) back into the donor's blood. The machine does not cause pain.
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