text:
About Us
There are many avenues pursued by people who enter into and ultimately choose the food service profession as their life's career. Some begin in entry level positions such as a waitress, bartender or busser working part time while in school, planning a career in another field. They eventually succumb instead to their love of the food industry. Others are born into it by virtue of it being the family business and, surprisingly, their training can begin at entry level, too! Their work experience generally includes food preparation, bartending, bussing tables, as well as acquiring management skills necessary to restaurant operation. It doesn't mean they don't have to work as hard; they usually work harder. The advantage to having the support and encouragement of an established family business is that there is considerably less trial and error to finding a successful formula, not to mention the built in labor pool you have to draw from.
Mark Arcobasso, owner of Domenico's Italian Restaurant and Lounge in Jefferson City, fits the above scenario to a "T". With wife, Vicki, the Arcobasso family tradition is more than two decades old, and begins with Mark's father, Joe, and the first "Domenico's" in St. Louis, which was named after grandfather Domenico "Nick" Arcobasso. The Arcobasso dynasty, which includes Mark's three sisters and two brothers, along with founder Joe, has formed a Missouri mini-conglomerate made up of: (in order of year of establishment) Domenico's in Florissant (1978); Concetta's in St. Charles (1985); Domenico's at the Lake of the Ozarks (1988); and Jefferson City's own Domenico's, which Mark opened in 1991. The Arcobasso family success in the food business has been extended into the retail trade with production of their own recipe salad dressings, including their extremely popular house Creamy Italian. Arcobasso Foods, which manufactures and distributes the family salad dressings, was founded in 1987, in St. Louis. Along with contributing to the quality of dining at their restaurants, these bottled salad dressings are available in various supermarkets in St. Louis, Kansas City and parts of Indiana.
Domenico's menu selection, while leaning toward Italian family specialties, such as their pastas with freshly made sauces, is equally renowned for it's beef and veal. The Missouri Beef Industry Council named Domenico's the "best steak restaurant" in the Jefferson City area. Their aged USDA choice beef elevates Domenico's to steakhouse status. Beef aficionados can be equally satisfied with selections of filet mignon, New York strip or prime rib. Veal dishes are lightly breaded and sauteed in olive oil, and includes a universal favorite, Veal Parmigiano. Seafood and chicken are also well represented. Offerings on the lighter side include Domenico's Chicken Stir Fry and Blackened Yellow Fin Tuna. For heart healthy entrees, try the Orange Roughy, Charbroiled Chicken Breast or the Hallie Special – a linguine with vegetables and red wine tomato sauce. Domenico's specials, such as Chicken Diablo, give new meaning to the word "special". Charbroiled chicken breast with provel cheese, artichokes, fresh mushrooms and piquant cream sauce – while an unusual combination – is the perfect Italian-style comfort food.
You will forget any logical reason you may have had for dieting when dessert time comes around. Chocolate Seduction Cake, Spumoni Ice Cream or the signature cheesecake are desserts guaranteed to tempt you. As are the beverages made with ice cream such as Nutty Irishman (Bailey's Frangelico and ice cream). Domenico's has eleven other beverage/ice cream combinations on the menu...all intriguing. The Cheesecake, which is New York Style, (including varieties such as Amaretto and Turtle), is made at Fazio's in St. Louis.
In 1996, Mark Arcobasso was named Restaurateur of the Year, honoring him for his capability in creating and maintaining a restaurant with quality food, reasonable prices, and friendly service in an environment that speaks of Old World Charm. This is a dining atmosphere where the decor includes family portraits on the walls and an elegant antique credenza. These are key elements prerequisite to success in the competitive business which has served the Arcobasso family well over the years.


text:
The story in Rainblood2 is right after the first game, with more plots, tricks, loves, and kills. According to one of the makers,"you will not feel satisfied until you reach the end of the game."
Different from Rainblood: Town of Death, in which everything was drawn by hand, the sequel is presented with a finer pixel art style, which supports far more fluent battle animations. The soundtracks in this game are totally merged with the mood, and define an appealing cultural background as well.
Rainblood: Town of Death was the first translated game from Chinese developer Soulframe, and it was released 3 years after the Chinese version. But talking about Rainblood2: City of Flame, Soulframe, who now has the experience in western market, says:"I bet this time it wouldn't be more than 3 months".

subset: commoncrawl


text:
From the reviews:
"This book deals with the influences of multicriteria analysis, decision support systems and artificial intelligence approaches on marketing approaches. Special emphasis is given to the area of new product development and formation penetration strategies. The authors claim that this is the first book bringing all these aspects together. … It is well written and clearly structured." (Stefan Nickel, Zentralblatt MATH, Vol. 1072 (23), 2005)


text:
Skydiving.com now has a network skydiving location serving Wabasso and Redwood County in Minnesota. Call Skydiving.com at 1-800-617-7948 for details, free information and specials on skydiving in Wabasso, MN today!
Popular Tags for Skydiving Wabasso:
Skydiving Wabasso, Skydiving in Wabasso, Sky Diving Wabasso, Skydive Wabasso MN, Skydiving 56293, Wabasso Skydiving, Skydiving Wabasso Minnesota, Skydiving near Wabasso, Skydiving in Wabasso Minnesota, Wabasso Sky Diving, Skydive 56293, Skydiving Wabasso MN, Skydive Wabasso, Skydiving Redwood County, Skydive in 56293, Skydiving MN, Sky Diving Wabasso MN, Wabasso, Minnesota
Sign up for our newsletter and receive updatesand specials on skydiving across America!


text:
Chattanooga Cares is putting its second annual Dining Out for Life event on Thursday April 26, 2012. Local venues have teamed up with the organization to raise awareness and funds for HIV and AIDS service organizations. Each dining establishment will donate a portion of the proceeds to the charitable funds. It is a great way to enjoy a evening of delicious dishes while providing contributions to a worth while cause. Check out the offical Chattanooga Cares-Dining Out for Life page to see the area participants. Click Here.
Chattanooga Cares-Dining Out for Life
Use your key for the next article


text:
Metropolis Los Angeles 1" Flat Iron
Metropolis Los Angeles 1" Flat Iron has an advanced one pass floating plate system and precision digital temperature control for faster, easier styling. Ultra smooth and extremely durable titanium flex plates offers a smooth glide down the hair shaft every time. Zero drag performance reduces frizz and creates sleek locks. Ionic and far infrared benefits smooth and tighten the hair shaft's outer cuticle layer so hair becomes more manageable, feels softer, and adds incredible shine. Digital adjustable temperature control up to 400F makes this a great choice no matter if your hair is thick, thin, short, or long.
Model#: 7025 /
Guaranteed AuthenticGuaranteed Authentic
Folica is an authorized distributer of this product and guarantees its authenticity.Close
- Ultra smooth titanium plates
- Extremely durable flex plates
- Advanced one pass floating plate system
- Precision digital temperature control
- Zero drag performance
- Excellent heat recovery time
- Digital variable temperature control with temperatures up to 400F
- Ionic and far infrared benefits
- Professional 10 foot long swivel cord
- 1-year limited warranty
To ensure best warranty service, please register your appliance on the Metropolis Technology website - http://www.metropolistechnology.com/customer_care/registration/ Any questions or concerns, please email firstname.lastname@example.com for support.
|Plug Type:
|Max Temperature:
|400 Degrees Fahrenheit
|Technology :
|Ionic, Infra-red, Digital
|Cord Type:
|Swivel Cord
|1 Year(s)
|Plate Size:
|1 Inch
|Cord Length:
|10 Foot
Folica's Warranty
Folica stands behind every product we sell and we honor all manufacturers' warranties. For all electrical appliances we offer complete protection. If you experience any problem with an item purchased from us and it's still under the warranty period, all you have to do is fill out our Warranty Replacement form, send us the items plus a small shipping and handling fee and we will take care of the rest. We'll repair or replace your item with a new product or a Folica Certified Refurbished product. It's that simple.
One Year Limit With This Flat IronAt first I was in love with this flat iron, but after having it for a year it malfunctioned & would no long turn on. This flat iron comes with a ten year warranty, so replacing it was no big deal (or so I thought). It took what felt like forever to get my replacement iron, then after another year with my new flat iron it broken too. Once again I sent in my broken iron & paid the twenty dollars for shipping & handling for my new flat iron. This time it took even longer to get my replacement falt iron (I'm in college & it took an entire semester to get it). Now it is another eleven months since getting my second replacement flat iron & it is once again broke. It turns on, but has stopped heating up. So within a three year time period I have been through three of these flat irons.Nov 7, 2012KaleyHAIR TYPENormal Hair
Use this link to send this review via e-mail, Twitter, or to post to your blog.Close
Best Flat Iron I've Used So Far.This flat iron heats rapidly
and keeps the same tempurature while you straignten your hair. It also makes great curls. I'm not sure if they all do, but mine came with a free hair protective spray, which was nice. I've had mine for about 6 years and it still works wonderfully.Aug 29, 2012KayHAIR TYPECurly Hair
Use this link to send this review via e-mail, Twitter, or to post to your blog.Close
Best Iron!Seriously the best flat Iron i have ever used. We use them at my work, which is a styling salon, and i have never seen a better flat iron curl than the ones that you get while using this iron. I highly recommend it!Jun 10, 2012Julia / CanadaHAIR TYPEMedium Brown / Curly Hair / Thick or Coarse Hair
Use this link to send this review via e-mail, Twitter, or to post to your blog.Close


text:
Brad Bournival
The Gazette
CLEVELAND — Since the turn of the century, the St. Ignatius football team has hoisted three championship banners in its gym for football. St. Edward has done it once.
Glenville? It's never happened.
Truth be told, the Tarblooders have only been to the state finals once — in 2009 — and even that came with a heartbreaking 16-15 loss to Hilliard Davidson.
But if fans want to start talking about recruiting and getting kids to the next level, it's not even close.
Tarblooders coach Ted Ginn Sr. has been the driving force behind more than 80 Glenville athletes getting Division I scholarships since 2000. It's a mark that is unequaled in the state and one that impresses even Ginn as his Tarblooders get ready to play Highland on Friday in a Division II state semifinal.
"I wouldn't say I thought it would blow up like it has, but I had expectations for that," Ginn said. "This kind of ran off the chain. It went crazy.
"It's hard for me to say what others do, but we develop the children. We develop the player and then we sell them a dream. Some buy into it, some don't. It's the ones that take it to the next level that succeed."
On any given Saturday — or Sunday, for that matter — it's not hard to stumble upon a former Tarblooder wreaking havoc on the gridiron.
Since Pierre Woods signed with Michigan in 2000, Ginn has had 39 players join Big Ten programs. Twenty of those players inked with Ohio State and scads of others found success in places like the SEC, Pac-12, ACC and other big-name conferences.
He has coached a Heisman Trophy winner (Troy Smith), Super Bowl participants (Woods, Ted Ginn Jr. and Donte Whitner) and has had countless players perform at the top level of college football.
The list is endless, as players like Shane Wynn at Indiana, Christian Bryant at Ohio State and V'Angelo Bentley at Illinois continue a tradition at Glenville that keeps churning out one superstar after the next.
"Football is the vehicle we use, but it's the things you do when you're not playing that get you that success," Ginn Sr. said. "It's a system — you can call it a formula — but you put the right ingredients in and it works.
"It's based on love, exposure and it's the educational side. You have to navigate through it all. A lot of times we take the education and it's all mixed up. You have to take that and make it make sense in terms of getting those scholarships.
"You take the kid to Ohio State and expose them to something they've never seen. You say, 'Look at that kid. Doesn't he look like you? Don't you think you could do the same things he does?' If they don't see it, they don't know what you're about."
The inner-city Cleveland school's success won't end anytime soon, as current seniors Marshon Lattimore and Erick Smith have already visited Alabama and Marcelys Jones has committed to Ohio State.
They learned the recruiting process when Ohio State freshman Christopher Worley and sophomore Devan Bogard went through it ahead of them. Justin Hardee went through the same thing in 2012 during his recruitment to Illinois and so did Sean Draper at Iowa. Ditto for Willie Henry at Michigan and Wynn with the Hoosiers.
"I was already a step ahead watching guys like Bogard and Worley and seeing them going through the process," Smith said. "It helps because we all push each other.
"It doesn't matter who you are. I remember as a sophomore, I was on scout defense going against guys like Bogard, Bentley and Hardee. You make each other better because of it."
Since 2000, coaches from more than 20 D-I college programs have signed a Glenville player, with many schools inking multiple recruits.
Ginn, whose son still plays in the NFL, could have retired years ago. The coach, who has mentored youth for more than four decades, is set for life. But he sees those that aren't, so he stays with it.
"The outside influences are out there," Ginn said. "There's someone asking them, 'Man, you think you can graduate, go to college and be a college player by going to Glenville or Ginn Academy?' Somebody says they can't be that.
"You have to be ahead of that. The world is set up for failure. This is my calling. This is my purpose. This is not a job. I'm doing what I love."
When someone like his son or Whitner or even Smith comes back to Glenville to say hello, Ginn makes sure others are around to hear the message from some of his past success stories.
The fact more than 30 Glenville players have picked up D-I scholarships in the last five years and are coming back gives players like current juniors Trevon Story, Milen Golden and Matthew Draper, who are already being recruited by big-time programs, the hope to move on to better things.
"These kids are already average," Ginn said. "You have to push past it. You have to push past normal. Normal means you're satisfied. What do you get out of that? The pride for me is that I helped someone have a life and they created another life and will help somebody else.
"It's about this: What have you done to improve the world? They're the example of hope for the next group. If the kids don't see it, we're just talking. It's the system. It's a mindset. It's Tarblooder Nation. It's how you think."
Contact Brad Bournival at email@example.com.


text:
Date: May 05 2012
Australia responded to being labelled the world's dirtiest women's water polo team by beating up Britain on the scoreboard at the London Olympic test event.
The 10-4 victory came only hours after British player Frankie Snell's accusations surfaced in the British press.
''The Australians are known for being the dirtiest,'' she said.
Snell said the British team held a grudge after teammate Alex Rutlidge broke a rib during Australia's 5-0 series victory earlier this year.
Australian Melissa Rippon was surprised at Snell's comments. ''I am not sure if that is a title I like,'' she said.
This material is subject to copyright and any unauthorised use, copying or mirroring is prohibited.
[ The Age | Text-only index]


text:
Dec 7, 2011 9:06 AM
For whatever reason (probably the exponentially increasing number of cats in our house), we've been given tons of little books about cats, and this year we wouldn't be surprised to receive this Cats in Costumes Zine Comic ($4). It features 22 pages of, well, illustrated cats in costumes ranging from timeless to topical. Maybe this year we'll turn the tables and use them as stocking stuffers for our friends with not enough cats.
If you've got a product or service that you'd like to promote on Outblush, click here to find out about our advertising opportunities.
Outblush is a blog for girls who love to shop. Our staff digs up the best clothes, home stuff, beauty items, and more. New items are posted every day — bookmark us and check out:


text:
Many call the day of the Academy Awards the Super Bowl for movie fans, but for others it's like cinematic tax day. And those who are paying the price for their filmic indiscretions in 2013 are those responsible for inflicting After Earth and Movie 43 on us.
The Razzie Awards came out with their awards for the worst movies and performances of 2013, and *shocker* there's not an Adam Sandler sighting to be found. Instead, their wrath is aimed at another soft target: Will and Jaden Smith. Will took home Worst Actor for his performance in After Earth, with Jaden taking Worst Supporting It's worth noting that the Razzies, which have become more pointless than ever as they aim for easy comedy targets that will gain them media attention, didn't recognize that Jaden was the lead actor in After Earth but it doesn't really matter.
If there's such a thing as the top Razzie awards, then Movie 43 took them all. The sketch comedy, which features an Oscar-worthy cast in a seemingly endless series of unfunny gross-out gags, earned Worst Movie, Worst Screenplay, and Worst Director awarded to all 13 directors who took part in making it happen. Other easy targets for the Razzies were the box office bomb, The Lone Ranger, and Kim Kardashian for her supporting appearance in Tyler Perry's Temptation. Full announcement is below:
The results are in, the envelopes have been opened, and the "winners" of the 34th Awards have been unveiled in ceremonies held at Hollywood's coolest new venue — just down the street from Sunday night's Oscars — IgnitedSpaces. The hour long show handed out at least one statuette to four of the five Worst Picture nominees, but Adam Sandler and his unfunny follow up Grown Ups 2 went home empty-handed.
Taking three of the top awards was the star-studded, snicker-free sketch comedy Movie 43, which "won" for Worst Screenplay (written by at least 19 people), Worst Director ("credited" to 13 people), and Worst Picture. Tying with 43, and also "winning" 3 gold spray-painted trophies, was the Will and Jaden Smith sci-fi fiasco After Earth. Dad Will Smith took Worst Supporting Actor, son Jaden was named Worst Lead Actor, and the combination of father & son, described in the ceremony as being "stranded on Planet Nepotism", took the award for Worst Screen Combo.
Rounding out the names read when the envelopes were torn were: Tyler Perry (in drag) as Worst Actress for his 8th time playing the cross-dressing character in A Madea Christmas; Kim Kardashian in Tyler Perry's Temptation as Worst Supporting Actress; and the year's biggest box office bomb, a $250 million "reboot" of The Lone Ranger (on which Disney took a $200 million tax write off) which was chosen as Worst Remake/Rip-Off or Sequel.


text:
Las Vegas Best Amusement Parks
December 18, 2013
Besides the casinos and clubs, Las Vegas features masses of other attractions close to the strip. Some of the finest are also some of the most strange, including amusement parks in Las Vegas. Some great examples are given below.
Dig This
One of the latest theme parks in Las Vegas, but rapidly becoming quite popular is Dig This. This site permits clients to operate heavy apparatus utilized in construction, using a mixture of excavators and bulldozers. After safety instruction, clients are let lose with their rigs in a large dust filled construction site and led through an earth-moving experience lasting up to 3 hours. The cabs are air-conditioned and operated under the guidance of an instructor. Driver's license isn't needed.
Vegas Indoor Skydiving
Ever wished to try skydiving but the thought of jumping from heights daunts you? This is the solution. After a short instruction period, guests change into jump suits and then enter a wind tunnel that lifts you up in the air and feels like you are flying. Guests remain under surveillance while flying and are safely brought back to the ground when the flight is over. Lasting roughly an hour, this amusement park in Las Vegas is a great way to spend part of your trip.
Exotics Racing
Ever wished to be a race driver? Here is your chance. Found at the LV Motor Speedway, Exotics Racing gives its customers a range of driving five laps in a Ferrari, Lamborghini, Aston Martin, Porsche, Nissan GT-R or Audi R8 sports cars. Newer models are added to the available cars yearly. Each driver is under the direction of a safety instructor. Another choice available is simply to be a passenger while a pro race car driver drives the sports vehicle round the track at a velocity over 200 mph.
Adventure Dome Theme Parks
These indoor theme parks in Las Vegas at the Circus Circus are open to everyone. It is not important to be a guest of the Circus Circus to go to visit the park. This is a real family activity in Vegas where everybody will find something interesting to do. There are roller coasters, Ferris wheels, aerial buses, midway games of all kinds, a sizeable arcade, mini bowling center and access to free circus shows. All of this is available for one entry price for all day access.
Red Rock Canyon National Conservation Area
Want to run away from all the lights for awhile? Red Rock Ravine is a nationwide park 13 miles outside of Vegas and will give you a wonderful view of the natural plants and animals in the Nevada area. Animals include roadrunners, jack rabbits, butterflies and various birds. Plants include the Joshua tree, scrub oak, cottonwood, and a few kinds of yucca. Going to the visitor center, you can organize for led walks or self guided tours of the 13 mile drive through the park. It is a good idea to bring water and any food you want to eat with you as the sole buy at the park is the gift shop which just has one or two snacks.
What About Las Vegas Water Parks?
LV seems a cool place for water parks, but Las Vegas water parks closed in 2007. With the swimming pools at the hotels and resorts, the Las Vegas water parks just didn't draw enough business.
Take a day or two on your vacation to Las Vegas to go to at least one of the amusement parks in this incredible city.
James Darien has been interested in tourism Las Vegasfor many years. He has written op-eds and editorial pieces about attractions in Vegas for many online publications. For more info about theme parks in Las Vegas feel free to visit his site.


text:
Uploaded by Yana Buzby , Mar 23 2011 02:47 PM
- Owner: Yana Buzby (View all images and albums)
- Uploaded: Mar 23 2011 02:47 PM
- Views: 1,051
- Album: Yana's Stuff
Great work, Yana, your kettle looks really shiny! Well done
This is an outstanding example of the kettle, well done Yana!
Thank you so much!... It is probably sounds weird, but I am so in love with my kettle that I am planning to frame it and put it on the wall
It's a beautiful kettle Yana, it should be framed.


text:
Up Movie Reviews
Release Date: May 29, 2009
Genre: AnimationAction/Adventure
Rating: (PG)
User reviews on Up
jasdf jasdf jasdf jasdf jasdf jasdfj ;lkj ;likj;lkj; ;lokj;lkj ;lkj ;likj ;lka asd fasd fasd fasd fasd fasd fas dfasdf; lkj;lkj;lkjlkj;lkj;lkj;lkj;lkasdfasdfasdf asdf asdf asdf asdf asdf lkjlkjlkj;lkj;lkj;lkj;lkasdfasd fasd fasd fasd fasd fasd fasd flk ;j;ljl;kj;lk;lkjlkj;lkjasdfasdfasd fadsfasd fasdfasdfasd fasdlkj;lkjlkjlkj;lkjl;kj;lkj;lasdfasdfasdfasdfsdfasdfasdfasdfasdkj;lkjlkjlkj;lkj;lkj;lkjasdfasdfal;ksdjf;lkjdafsdfas;lkjlljasdofij;weamowievcmo;iam;clkma;lsdkfjweiojavdo;jksldfukfsdfksdjfoasifja;wlkavmoasdkfja;sodfijoweifamsdlkvcjosiejweofjalksdjlsdkfjsldifjwefkjdsklfikjald;skfukadsfasdkfiaeifjkasdlkfsjdvoeiavnaoiekdcvklvjlsdkfajsdlkfjasitetsjifsdlkfsldhisdtsldkfjsldifsldihsdlasl falsdkfhaweoiasldkasdfhsifhsithsdlkfjasdlfiasdflsdfjlsakdfhsdfls***f sdltkjsadlfkjsadlfaksdjfsldfkjasdlfkasdjtlkjfliajsldktjawoeijaodjfasoiejoawiejfowjeovfweijvoaijdglsdkgh osiufjasoicvmjsdlkfjaslufosfjaosdjfoadjfasodfhsdlfislidhsldhsdlifhsaldieihsidjfhaisofsaklasefsdlkfjasld falsdkfjsaldkfj asdlkfjalsd sdfg sdf gs dfg sdfg sdf g
I was pleasantly surprised with Up. Probably the most fun I've had at a Pixar movie since Toy Story, and certainly the best Pixar since Finding Nemo. It is a great family movie with plenty to entertain the kids and many more laughs than I would have expected. Unexpectedly poignant at times, but good fun overall
WOW! Pixar continues to amaze. 3-D was a wonderful way to take in the scenery. A sweet story of love and committment. Pixar always has a message and that is what makes them special in an age of cookie-cutter CGI flicks. Keep up the good work... let's hope Toy Story 3 lives up to the challenge.
Up looks like a good movie.on saturday june 6th me and my boyfriend are going to see it with my boyfriend.So keep looking and ill write back after i watch it.and then tell me wat u think of the movie please??okayy bye-bye.im out yo.peace:]]hehe.ok forreal bye
Write a review for Up
Login to write review:


text:
More New and Used
from Private Sellers
Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
White Party, White Government: Race, Class, and U.S. Politics
ISBN13:by Feagin; Joe R.
Nonspecific Binding
Questions About This Book?
Why should I rent this book?
Renting is easy, fast, and cheap! Renting from eCampus.com can save you hundreds of dollars compared to the cost of new or used books each semester. At the end of the semester, simply ship the book back to us with a free UPS shipping label! No need to worry about selling it back.
How do rental returns work?
Returning books is as easy as possible. As your rental due date approaches, we will email you several courtesy reminders. When you are ready to return, you can print a free UPS shipping label from our website at any time. Then, just return the book to your UPS driver or any staffed UPS location. You can even use the same box we shipped it in!
What version or edition is this?
This is the 1st edition with a publication date of 2/23/2012.
What is included with this book?
- The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any CDs, lab manuals, study guides, etc.
- The Used copy of this book is not guaranteed to include any supplemental materials. Typically, only the book itself is included.
- The Rental copy of this book is not guaranteed to include any supplemental materials. You may receive a brand new copy, but typically, only the book itself.
White Party, White Government examines the centuries-old impact of systemic racism on the U.S. political system. The text assesses the development by elite and other whites of a racialized capitalistic system, grounded early in slavery and land theft, and its intertwining with a distinctive political system whose fundamentals were laid down in the founding decades. From these years through the Civil War and Reconstruction, to the 1920s, the 1930s Roosevelt era, the 1960s Johnson era, through to the Ronald Reagan, George H.W. Bush, and Barack Obama presidencies, Feagin exploring the effects of ongoing demographic changes on the present and future of the U.S. political system.
Author Biography
Joe R. Feagin is Ella C. McFadden Professor at Texas A M University. He has done research on racism and sexism issues for forty-six years and has served as the Scholar-in-Residence at the U.S. Commission on Civil Rights. He has written fifty-eight scholarly books and nearly two hundred scholarly articles in his research areas, and one of his books, Ghetto Revolts, was nominated for a Pulitzer Prize. His recent books include Systemic Racism (Routledge 2006), The White Racial Frame (Routledge 2010), and Racist America (2nd edition, Routledge 2010). He is the 2006 recipient of a Harvard alumni association lifetime achievement award and was the 1999-2000 President of the American Sociological Association.
Table of Contents
|p. vii
|Framing a Racist America: Puritan Inheritances and Political Framing
|p. 1
|Faking Democracy: Race, Class, and Our Undemocratic Political System
|p. 16
|Race, Class, and Early U.S. Politics-to the 1930s
|p. 35
|Race, Class, and U.S. Politics: 1930s-1970s
|p. 61
|Race, Class, and U.S. Politics: 1970s-1990s
|p. 86
|The George W. Bush Era: Racial and Class Dimensions
|p. 122
|The Barack Obama Presidential Campaign
|p. 143
|Barack ObamaÆs Presidency: Racial and Class Dimensions
|p. 166
|Demographic Change and Political Futures
|p. 194
|p. 209
|p. 233
|Table of Contents provided by Ingram. All Rights Reserved.


text:
Dusty and Scooter were once beloved pups. Unfortunately for these two seniors, their owner recently died and now they find themselves alone in a scary, hot, old municipal-run shelter with lots of noise and surrounded by even more death. The owner's family could not deal with them for reasons unknown and turned them over to the San Bernardino City Shelter.
Dusty is an unaltered female. She is a tan and white Labrador mix. A shelter staff member guesses that she is about 13 years old.
Dusty's best friend is Scooter, a neutered male Chihuahua mix. He is tan and black. He is 18 years old according to shelter staff but does not look his age.
These two friends do not stand much of a chance of getting out alive unless someone steps forward in the next couple of days to rescue them. The pair entered the shelter on June 18. They could be euthanized at any time for space or if they come down with kennel cough or exhibit any sign of illness.
According to Andrea Neyses, a local animal advocate who took the photo above, both Dusty and Scooter are very well-behaved. She says they walk well on a leash, and they are good to one another. She says she would guess their ages to be closer to 7 or 8 as both are spunky and get around well.
But they are in a scary, germ-filled place, where at their age, they are more susceptible to disease. Due to their senior status, it is imperative someone they find a new home as quickly as possible.
Dusty and Scooter are bonded. These best friends hope someone finds it in their heart to adopt them as a pair to live out their retirement together.
San Bernardino City Shelter is a high-kill shelter. It remains controversial due its euthanasia policies and lack of treatment of sick and injured animals.
Disease is rampant in the shelter. The shelter is old and moldy. Shelter staff members euthanize animals at the first sign of kennel cough or upper respiratory issues.
To learn more about Dusty and Scooter, contact the San Bernardino City Shelter at 909.384.1304. Dusty's animal identification number is A467607. Scooter's animal identification number is A467609. Follow them on Facebook at: Dusty and Scooter.


text:
10 Most Violent Juggalo Attacks Ever
From killing a girl then having sex with her corpse, to tying up a grandmother, beating her with pots and pans and then stealing her car, here are the 10 most heinous Juggalo crimes of all time (other than listening to Insane Clown Posse Albums). Because Tila Tequila got attacked, then mobbed, by a group of Juggalos (the subculture built around the Insane Clown Posse, known for their violence and crimes), I've put together the most craziest crimes ever committed by them, just to put it into perspective that Tila got off EASY.
Also, this just goes to show that although ICP is barely relevant anymore, their fanbase continues to be the worst fanbases of all time. Of course, ICP themselves aren't really the "cause" of any of this, but it'd be neglectful to say that the subculture they've created doesn't play a part. I'm sure we'd find an insane amount of news of far worse crimes (even though these are pretty crazy) if we put a list of Garth Brooks, Keith Urban, Puff Daddy, or even U2 fan crimes together. But fandom of those bands isn't really reported whenever someone commits a heinous crime, is it? Just food for thought. Now onto the crimes.


text:
07 October 2008
Make mommie crack.
Hunter's trick to get out of trouble is to look at me with sad eyes and then give me a big old smile like "you can't be mad at me I am too cute". If I hold strong and don't smile he starts talking and touching my face. If I hold strong through that he starts laughing and tries to give me a hug. I am weak I tell you.
Posted by Mercedes at 9:44 AM
No comments:
Subscribe to: Post Comments (Atom)


text:
Malaysia Airlines plane crash: Tragedy heightens anxiety for families waiting at Sky Harbor Airport
PHOENIX - The Malaysian Airline tragedy won't stop people from flying in and out of Phoenix's Sky Harbor Airport, but it certainly heightened anxiety for some waiting for international arrivals Thursday.
Dawn Brasch is a host family with EF High School Exchange Year. She was waiting to welcome her twelfth exchange student on a connecting flight from London, who was traveling with a group of seven others, when she learned about MA17.
News of the crash immediately had her double-checking flight schedules.
"It worries you, you wonder where they are flying, what kids are flying at what time and where they're flying over," Brasch said.
Parents who had sent their children to the United States were equally anxious to hear from Brasch when they were safe on the ground.
"The families are just up waiting for their children, waiting to hear they've touched down and landed and their host family has greeted them."
Brasch says even when you know the flight you're expecting isn't involved, you still feel unsettled thinking there were likely families just like yours waiting at an arrival gate for a flight that would unexpectedly never land.
We also spoke to a retired pilot Ron Nielsen.
He says what this tragedy means for travelers is that airlines will probably change how they navigate around Ukraine and those flights could be longer.
Also, Nielsen says instances like this force commercial airlines to re-evaluate their safety measures which could help more travelers in the long run.


text:
Professor Gil McVean FRS FMedSci
|Research Area:
|Genetics and Genomics
|Technology Exchange:
|Bioinformatics, SNP typing and Statistical genetics
|Scientific Themes:
|Genetics & Genomics
|Population genetics, Coalescent modelling, HLA imputation, de novo assembly and Statistical Genetics
|Web Links:
My research covers several areas in the analysis of genetic variation, combining the development of methods for analysing high throughput sequencing data, theoretical work and empirical analysis. Of particular interest are: the analysis of recombination from population genetic data, dissecting signals of disease association within the HLA, methods for inferring genealogical history from DNA sequence data and de novo sequence assemblyfor the discovery of genetic variation. I am a member of the Mathematical Genetics Group in the Department of Statistics and Acting Director of the new Oxford Big Data Institute.
|Professor Peter Donnelly FRS
|Wellcome Trust Centre for Human Genetics
|University of Oxford
|United Kingdom
|Professor Dominic Kwiatkowski
|Wellcome Trust Centre for Human Genetics
|University of Oxford
|United Kingdom
|Professor Simon Myers
|Wellcome Trust Centre for Human Genetics
|University of Oxford
|United Kingdom
|Prof Andrew OM Wilkie FRS FMedSci FRCP (RDM)
|Nuffield Division of Clinical Laboratory Sciences
|University of Oxford
|United Kingdom
|Prof Lars Fugger (RDM)
|Weatherall Institute of Molecular Medicine
|University of Oxford
|United Kingdom
|Professor Jonathan Flint
|Wellcome Trust Centre for Human Genetics
|University of Oxford
|United Kingdom
|Professor Molly Przeworski
|Department of Human Genetics and Department of Ecology and Evolution
|Columbia University
|United States
|The 1000 Genomes Project
|Wellcome Trust
|United Kingdom
Nat Genet, 47 (7), pp. 717-726. Read abstract | Read more2015. Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified no pathogenic variants. We quantified the number of candidate variants identified using different strategies for variant calling, filtering, annotation and prioritization. We found that jointly calling variants across samples, filtering against both local and external databases, deploying multiple annotation tools and using familial transmission above biological plausibility contributed to accuracy. Overall, we identified disease-causing variants in 21% of cases, with the proportion increasing to 34% (23/68) for mendelian disorders and 57% (8/14) in family trios. We also discovered 32 potentially clinically actionable variants in 18 genes unrelated to the referral disorder, although only 4 were ultimately considered reportable. Our results demonstrate the value of genome sequencing for routine clinical diagnosis but also highlight many outstanding challenges. Hide abstract
Nat Genet, 47 (6), pp. 682-688. Read abstract | Read more2015. Improved genome inference in the MHC using a population reference graph.
Although much is known about human genetic variation, such information is typically ignored in assembling new genomes. Instead, reads are mapped to a single reference, which can lead to poor characterization of regions of high sequence or structural diversity. We introduce a population reference graph, which combines multiple reference sequences and catalogs of variation. The genomes of new samples are reconstructed as paths through the graph using an efficient hidden Markov model, allowing for recombination between different haplotypes and additional variants. By applying the method to the 4.5-Mb extended MHC region on human chromosome 6, combining 8 assembled haplotypes, the sequences of known classical HLA alleles and 87,640 SNP variants from the 1000 Genomes Project, we demonstrate using simulations, SNP genotyping, and short-read and long-read data how the method improves the accuracy of genome inference and identified regions where the current set of reference sequences is substantially incomplete. Hide abstract
SCIENCE, 344 (6189), pp. 1272-1275. | Read more2014. NONHUMAN GENETICS Strong male bias drives germline mutation in chimpanzees
BMC Evol Biol, 13 (1), pp. 110. Read abstract | Read more2013. Hypervariable antigen genes in malaria have ancient roots.
BACKGROUND: The var genes of the human malaria parasite Plasmodium falciparum are highly polymorphic loci coding for the erythrocyte membrane proteins 1 (PfEMP1), which are responsible for the cytoaherence of P. falciparum infected red blood cells to the human vasculature. Cytoadhesion, coupled with differential expression of var genes, contributes to virulence and allows the parasite to establish chronic infections by evading detection from the host's immune system. Although studying genetic diversity is a major focus of recent work on the var genes, little is known about the gene family's origin and evolutionary history. RESULTS: Using a novel hidden Markov model-based approach and var sequences assembled from additional isolates and species, we are able to reveal elements of both the early evolution of the var genes as well as recent diversifying events. We compare sequences of the var gene DBLα domains from divergent isolates of P. falciparum (3D7 and HB3), and a closely-related species, Plasmodium reichenowi. We find that the gene family is equally large in P. reichenowi and P. falciparum -- with a minimum of 51 var genes in the P. reichenowi genome (compared to 61 in 3D7 and a minimum of 48 in HB3). In addition, we are able to define large, continuous blocks of homologous sequence among P. falciparum and P. reichenowi var gene DBLα domains. These results reveal that the contemporary structure of the var gene family was present before the divergence of P. falciparum and P. reichenowi, estimated to be between 2.5 to 6 million years ago. We also reveal that recombination has played an important and traceable role in both the establishment, and the maintenance, of diversity in the sequences. CONCLUSIONS: Despite the remarkable diversity and rapid evolution found in these loci within and among P. falciparum populations, the basic structure of these domains and the gene family is surprisingly old and stable. Revealing a common structure as well as conserved sequence among two species also has implications for developing new primate-parasite models for studying the pathology and immunology of falciparum malaria, and for studying the population genetics of var genes and associated virulence phenotypes. Hide abstract
Science, 339 (6127), pp. 1578-1582. Read abstract | Read more2013. Multiple instances of ancient balancing selection shared between humans and chimpanzees.
Instances in which natural selection maintains genetic variation in a population over millions of years are thought to be extremely rare. We conducted a genome-wide scan for long-lived balancing selection by looking for combinations of SNPs shared between humans and chimpanzees. In addition to the major histocompatibility complex, we identified 125 regions in which the same haplotypes are segregating in the two species, all but two of which are noncoding. In six cases, there is evidence for an ancestral polymorphism that persisted to the present in humans and chimpanzees. Regions with shared haplotypes are significantly enriched for membrane glycoproteins, and a similar trend is seen among shared coding polymorphisms. These findings indicate that ancient balancing selection has shaped human variation and point to genes involved in host-pathogen interactions as common targets. Hide abstract
Nature, 488 (7412), pp. 508-511. Read abstract | Read more2012. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Although there has been much success in identifying genetic variants associated with common diseases using genome-wide association studies (GWAS), it has been difficult to demonstrate which variants are causal and what role they have in disease. Moreover, the modest contribution that these variants make to disease risk has raised questions regarding their medical relevance. Here we have investigated a single nucleotide polymorphism (SNP) in the TNFRSF1A gene, that encodes tumour necrosis factor receptor 1 (TNFR1), which was discovered through GWAS to be associated with multiple sclerosis (MS), but not with other autoimmune conditions such as rheumatoid arthritis, psoriasis and Crohn's disease. By analysing MS GWAS data in conjunction with the 1000 Genomes Project data we provide genetic evidence that strongly implicates this SNP, rs1800693, as the causal variant in the TNFRSF1A region. We further substantiate this through functional studies showing that the MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF. Importantly, TNF-blocking drugs can promote onset or exacerbation of MS, but they have proven highly efficacious in the treatment of autoimmune diseases for which there is no association with rs1800693. This indicates that the clinical experience with these drugs parallels the disease association of rs1800693, and that the MS-associated TNFR1 variant mimics the effect of TNF-blocking drugs. Hence, our study demonstrates that clinical practice can be informed by comparing GWAS across common autoimmune diseases and by investigating the functional consequences of the disease-associated genetic variation. Hide abstract
Nat Genet, 44 (3), pp. 243-246. Read abstract | Read more2012. Differential confounding of rare and common variants in spatially structured populations.
Well-powered genome-wide association studies, now made possible through advances in technology and large-scale collaborative projects, promise to characterize the contribution of rare variants to complex traits and disease. However, while population structure is a known confounder of association studies, it remains unknown whether methods developed to control stratification are equally effective for rare variants. Here, we demonstrate that rare variants can show a stratification that is systematically different from, and typically stronger than, common variants, and this is not necessarily corrected by existing methods. We show that the same process leads to inflation for load-based tests and can obscure signals at truly associated variants. Furthermore, we show that populations can display spatial structure in rare variants, even when Wright's fixation index F(ST) is low, but that allele frequency-dependent metrics of allele sharing can reveal localized stratification. These results underscore the importance of collecting and integrating spatial information in the genetic analysis of complex traits. Hide abstract
Nat Genet, 44 (2), pp. 226-232. Read abstract | Read more2012. De novo assembly and genotyping of variants using colored de Bruijn graphs.
Detecting genetic variants that are highly divergent from a reference sequence remains a major challenge in genome sequencing. We introduce de novo assembly algorithms using colored de Bruijn graphs for detecting and genotyping simple and complex genetic variants in an individual or population. We provide an efficient software implementation, Cortex, the first de novo assembler capable of assembling multiple eukaryotic genomes simultaneously. Four applications of Cortex are presented. First, we detect and validate both simple and complex structural variations in a high-coverage human genome. Second, we identify more than 3 Mb of sequence absent from the human reference genome, in pooled low-coverage population sequence data from the 1000 Genomes Project. Third, we show how population information from ten chimpanzees enables accurate variant calls without a reference sequence. Last, we estimate classical human leukocyte antigen (HLA) genotypes at HLA-B, the most variable gene in the human genome. Hide abstract
Science, 336 (6078), pp. 193-198. Read abstract | Read more2012. A fine-scale chimpanzee genetic map from population sequencing.
To study the evolution of recombination rates in apes, we developed methodology to construct a fine-scale genetic map from high-throughput sequence data from 10 Western chimpanzees, Pan troglodytes verus. Compared to the human genetic map, broad-scale recombination rates tend to be conserved, but with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancestral fusion in human chromosome 2. At fine scales, chimpanzee recombination is dominated by hotspots, which show no overlap with those of humans even though rates are similarly elevated around CpG islands and decreased within genes. The hotspot-specifying protein PRDM9 shows extensive variation among Western chimpanzees, and there is little evidence that any sequence motifs are enriched in hotspots. The contrasting locations of hotspots provide a natural experiment, which demonstrates the impact of recombination on base composition. Hide abstract
Nature, 491 (7422), pp. 56-65. Read abstract | Read more2012. An integrated map of genetic variation from 1,092 human genomes.
By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes of 1,092 individuals from 14 populations, constructed using a combination of low-coverage whole-genome and exome sequencing. By developing methods to integrate information across several algorithms and diverse data sources, we provide a validated haplotype map of 38 million single nucleotide polymorphisms, 1.4 million short insertions and deletions, and more than 14,000 larger deletions. We show that individuals from different populations carry different profiles of rare and common variants, and that low-frequency variants show substantial geographic differentiation, which is further increased by the action of purifying selection. We show that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites. This resource, which captures up to 98% of accessible single nucleotide polymorphisms at a frequency of 1% in related populations, enables analysis of common and low-frequency variants in individuals from diverse, including admixed, populations. Hide abstract
Bioinformatics, 27 (7), pp. 968-972. Read abstract | Read more2011. HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes.
MOTIVATION: Genetic variation at classical HLA alleles influences many phenotypes, including susceptibility to autoimmune disease, resistance to pathogens and the risk of adverse drug reactions. However, classical HLA typing methods are often prohibitively expensive for large-scale studies. We previously described a method for imputing classical alleles from linked SNP genotype data. Here, we present a modification of the original algorithm implemented in a freely available software suite that combines local data preparation and QC with probabilistic imputation through a remote server. RESULTS: We introduce two modifications to the original algorithm. First, we present a novel SNP selection function that leads to pronounced increases (up by 40% in some scenarios) in call rate. Second, we develop a parallelized model building algorithm that allows us to process a reference set of over 2500 individuals. In a validation experiment, we show that our framework produces highly accurate HLA type imputations at class I and class II loci for independent datasets: at call rates of 95-99%, imputation accuracy is between 92% and 98% at the four-digit level and over 97% at the two-digit level. We demonstrate utility of the method through analysis of a genome-wide association study for psoriasis where there is a known classical HLA risk allele (HLA-C*06:02). We show that the imputed allele shows stronger association with disease than any single SNP within the region. The imputation framework, HLA*IMP, provides a powerful tool for dissecting the architecture of genetic risk within the HLA. AVAILABILITY: HLA*IMP, implemented in C++ and Perl, is available from http://oxfordhla.well.ox.ac.uk and is free for academic use. Hide abstract
Nature, 476 (7359), pp. 214-219. Read abstract | Read more2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis. Hide abstract
Nature, 467 (7319), pp. 1061-1073. Read abstract | Read more2010. A map of human genome variation from population-scale sequencing.
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project, designed to develop and compare different strategies for genome-wide sequencing with high-throughput platforms. We undertook three projects: low-coverage whole-genome sequencing of 179 individuals from four populations; high-coverage sequencing of two mother-father-child trios; and exon-targeted sequencing of 697 individuals from seven populations. We describe the location, allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms, 1 million short insertions and deletions, and 20,000 structural variants, most of which were previously undescribed. We show that, because we have catalogued the vast majority of common variation, over 95% of the currently accessible variants found in any individual are present in this data set. On average, each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited disorders. We demonstrate how these results can be used to inform association and functional studies. From the two trios, we directly estimate the rate of de novo germline base substitution mutations to be approximately 10(-8) per base pair per generation. We explore the data with regard to signatures of natural selection, and identify a marked reduction of genetic variation in the neighbourhood of genes, due to selection at linked sites. These methods and public data will support the next phase of human genetic research. Hide abstract
Science, 327 (5967), pp. 876-879. Read abstract | Read more2010. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multiple lines of evidence suggest that the rapidly evolving zinc-finger protein PRDM9 binds to this motif and that sequence changes in the protein may be responsible for hotspot differences between species. The involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes but raises questions about what forces have driven such rapid change. Hide abstract
PLoS Genet, 5 (10), pp. e1000686. Read abstract | Read more2009. A genealogical interpretation of principal components analysis.
Principal components analysis, PCA, is a statistical method commonly used in population genetics to identify structure in the distribution of genetic variation across geographical location and ethnic background. However, while the method is often used to inform about historical demographic processes, little is known about the relationship between fundamental demographic parameters and the projection of samples onto the primary axes. Here I show that for SNP data the projection of samples onto the principal components can be obtained directly from considering the average coalescent times between pairs of haploid genomes. The result provides a framework for interpreting PCA projections in terms of underlying processes, including migration, geographical isolation, and admixture. I also demonstrate a link between PCA and Wright's f(st) and show that SNP ascertainment has a largely simple and predictable effect on the projection of samples. Using examples from human genetics, I discuss the application of these results to empirical data and the implications for inference. Hide abstract
Nat Genet, 40 (9), pp. 1124-1129. Read abstract | Read more2008. A common sequence motif associated with recombination hot spots and genome instability in humans.
In humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer CCTCCCT. Here we use the increased hot-spot resolution afforded by the Phase 2 HapMap and novel search methods to identify an extended family of motifs based around the degenerate 13-mer CCNCCNTNNCCNC, which is critical in recruiting crossover events to at least 40% of all human hot spots and which operates on diverse genetic backgrounds in both sexes. Furthermore, these motifs are found in hypervariable minisatellites and are clustered in the breakpoint regions of both disease-causing nonallelic homologous recombination hot spots and common mitochondrial deletion hot spots, implicating the motif as a driver of genome instability. Hide abstract
Am J Hum Genet, 82 (1), pp. 48-56. Read abstract | Read more2008. A statistical method for predicting classical HLA alleles from SNP data.
Genetic variation at classical HLA alleles is a crucial determinant of transplant success and susceptibility to a large number of infectious and autoimmune diseases. However, large-scale studies involving classical type I and type II HLA alleles might be limited by the cost of allele-typing technologies. Although recent studies have shown that some common HLA alleles can be tagged with small numbers of markers, SNP-based tagging does not offer a complete solution to predicting HLA alleles. We have developed a new statistical methodology to use SNP variation within the region to predict alleles at key class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) loci. Our results indicate that a single panel of approximately 100 SNPs typed across the region is sufficient for predicting both rare and common HLA alleles with up to 95% accuracy in both African and non-African populations. Furthermore, we show that HLA alleles can be successfully predicted by using previously genotyped SNPs that are within the MHC and that had not been chosen for their ability to predict HLA alleles, such as those included on genome-wide products. These results indicate that our methodology, combined with an extended database of reference haplotypes, will facilitate large-scale experiments, including disease-association studies and vaccine trials, in which detailed information about HLA type is valuable. Hide abstract
Nature, 449 (7164), pp. 851-861. Read abstract | Read more2007. A second generation human haplotype map of over 3.1 million SNPs.
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between 0.9 and 0.96 depending on population. We demonstrate that the current generation of commercial genome-wide genotyping products captures common Phase II SNPs with an average maximum r2 of up to 0.8 in African and up to 0.95 in non-African populations, and that potential gains in power in association studies can be obtained through imputation. These data also reveal novel aspects of the structure of linkage disequilibrium. We show that 10-30% of pairs of individuals within a population share at least one region of extended genetic identity arising from recent ancestry and that up to 1% of all common variants are untaggable, primarily because they lie within recombination hotspots. We show that recombination rates vary systematically around genes and between genes of different function. Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations. Hide abstract
PLoS genetics, 2 (9), Read abstract | Read more2006. The influence of recombination on human genetic diversity.
In humans, the rate of recombination, as measured on the megabase scale, is positively associated with the level of genetic variation, as measured at the genic scale. Despite considerable debate, it is not clear whether these factors are causally linked or, if they are, whether this is driven by the repeated action of adaptive evolution or molecular processes such as double-strand break formation and mismatch repair. We introduce three innovations to the analysis of recombination and diversity: fine-scale genetic maps estimated from genotype experiments that identify recombination hotspots at the kilobase scale, analysis of an entire human chromosome, and the use of wavelet techniques to identify correlations acting at different scales. We show that recombination influences genetic diversity only at the level of recombination hotspots. Hotspots are also associated with local increases in GC content and the relative frequency of GC-increasing mutations but have no effect on substitution rates. Broad-scale association between recombination and diversity is explained through covariance of both factors with base composition. To our knowledge, these results are the first evidence of a direct and local influence of recombination hotspots on genetic variation and the fate of individual mutations. However, that hotspots have no influence on substitution rates suggests that they are too ephemeral on an evolutionary time scale to have a strong influence on broader scale patterns of base composition and long-term molecular evolution. Hide abstract
The impact of HLA variation on the human phenotypic landscape
Genetic variation within the classical HLA genes influences a vast range of human phenotypes, from risk of auto-immune disease to adverse drug effects and response to vaccines. However, while many genetic associations have been discovered, to date, there has been no systematic attempt to bring together all such information into one place and to integrate it with large prospective studies to build a comprehensive map of how variation into these key genes influences the full spectrum of human phe ...
Using genomic diversity to map fine-scale epidemiology in malaria
The analysis of host-pathogen interactions is being transformed by the ability of sequencing technologies to measure genome-wide patterns of genetic variation in both parties. However, in order to make sense of these data, new statistical and mathematical approaches need to be developed that integrate spatial epidemiological modelling and the population genetics of pathogen variation. The aim of this project is to use sequencing data being generated by the Pf3k project on the primary malaria p ...


text:
Courtesy: Idaho Athletic Media Relations
|Vandal soccer adds three
MOSCOW, Idaho – University of Idaho soccer coach Pete Showler announced the signing of three new Vandals to the women's soccer team on Wednesday, the first day of National Letter of Intent signing day.
Idaho soccer welcomes forward Reagan Quigley (Woodinville, Wash.), midfielder Jocelyn "JP" Burgess (La Center, Wash.) and defender Josie Greenwood (Spokane, Wash.) to the program. All three will join the Vandals in the fall as freshmen.
"I'd like to take this opportunity to give credit to the hard work my staff and the people behind the scenes in our department who have been involved in this whole process," Showler said. "We've recruited three top-notch student-athletes with personality, pride, passion and great core values that will help us continue the positive momentum and direction our program is headed."
Quigley is a 5-6 forward who is a three-year varsity player who scored 42 goals in three seasons for Woodinville High School. She led the Falcons to the Washington 4A state quarterfinal in 2010 as a junior and earned 2011 All-KingCo 4A honorable mention accolades. She was also a state finalist in the 400m for the WHS track team and helped its 4x400m relay to a state runner-up finish in 2009.
Burgess is a 5-6 center mid who played varsity soccer all four years at La Center High School and ended her career with school-record totals of 70 goals and 78 assists. She was a 2011 Washington 1A Second-Team All-State selection, a 2010 Washington 1A First-Team All-State honoree and was the 2010 Trico League Offensive MVP. Burgess was also selected to the Olympic Development Program (ODP) national pool in 2010 and 2011.
Greenwood is a 5-11 defender for Lewis and Clark High School. She led the Tigers to a 14-3 overall record and a 7-2 Greater Spokane League tally in 2011. As a junior in 2010, she helped the Tigers to an 18-2-1 record and regular-season GSL title. She was a Washington 4A Second-Team All-State pick and a First-Team All-GSL honoree in 2010 as a junior. She helped Lewis and Clark advance to the Washington 4A state quarterfinal round in both 2009 and 2010.
Greenwood carries on an impressive string of Vandal players from the Spokane Shadow club team. She played club ball with current Vandals Annie Millard and Katie Baran, and Idaho's roster includes Shadow alumnae Liz Boyden, Chelsie Breen, Mary Condon, Erica Hart and Lauren Layton.
"They're getting quality coaching there and it's paying off," Showler said of the Shadow club team. "The number of players we have coming through that program and coming to Idaho is a reflection on that."
Idaho graduated one player, defender Alison "Larry" Page, from last year's squad that qualified for a second-consecutive Western Athletic Conference Tournament and advanced to the semifinal round for the first time in school history. Showler said that he's excited to see what the three new Vandals can add to an already-strong group.
"They're three girls who are great in the classroom, passionate about the game and with bubbling personalities – very exciting acquisitions for the Vandal family," Showler said. "Larry will be sadly missed, but we're bringing in three quality student-athletes who are going to give us great depth and competition at every spot."
2012 Idaho Soccer Signees:
Josie Greenwood
5-11, Defender
Spokane, Wash. (Lewis and Clark HS)
Club: Spokane Shadow (Kevin Moon)
Coach Showler says: "Josie is a very strong player … she's a powerful tackler and good in the air … she defends with purpose, so she's a great acquisition on our defensive line … she plays equally well centrally or outside … any time you get good height, it's going to cause problems defensively and also on the offensive side with set pieces and corners."
High School/Club: Greenwood is a two-year varsity starter for Lewis and Clark High School … led Lewis and Clark to a 14-3-0 overall record and a 7-2-0 tally in the GSL in 2011 for a third-place league finish … 2010 Washington 4A Second-Team All-State … 2010 First-Team All-Greater Spokane League … helped lead Lewis and Clark to an 18-2-1 record and regular-season GSL title in 2010 … helped her team advance to the Washington 4A state quarterfinals in both 2009 and 2010 … plays for the Spokane Shadow club team … helped lead the Shadow to the Washington State Cup semifinals in 2009 and 2010 … also helped the team advance to the U.S. Club Soccer regional semifinal and the Denver Cup semifinal … in 2007, she helped the team claim the U.S. Club Soccer Region G Premier title, as well as the Super Y League Northwest crown and a berth to the Super Y League National Finals … sister Lexi plays soccer at Portland State.
Jocelyn "JP" Burgess
5-6, Midfielder
La Center, Wash. (La Center HS)
Club: VUSA Premier (Steve Studley)
Coach Showler says: "JP has a phenomenal soccer IQ … she's very smart about how she plays the game and she has great vision … we watched her recently at a tournament and she played outside back, outside mid, center mid, and forward – she can adapt to any situation and she has the tools to do it well … she's a crafty, tricky player … she brings the whole package and she's going to bolster a fantastic central midfield that we already have."
High School/Club: Burgess was a four-year varsity player for La Center High School … 2011 First-Team All-Trico League … 2011 Washington 1A Second-Team All-State … scored all three goals for La Center in a 3-2 win over Tenino HS in the district tournament to clinch a 2011 Washington 1A state tournament bid … 2010 Washington 1A First-Team All-State … 2010 Trico League Offensive MVP … 2009 First-Team All-Trico League … finished her career with school-record totals of 70 goals and 78 assists … plays for the VUSA Timbers club team … was voted 2010 Female Athlete of the Year for the VUSA Premier SC … while with Eastside FC, she helped lead the team to a 2010 U.S. Soccer regional title, THUSC College Showcase title, 2009 Surf Cup College Showcase title, a 2009 Washington PDL Division title, a 2008 Chinook Cup championship and a third-place national finish in 2007 … was invited to the Olympic Development Program national training pool in 2010 and 2011, as well as the ODP National Development Camp in 2010 … was voted student body president at La Center High School in the 2010-11 school year
Reagan Quigley
5-6, Forward
Woodinville, Wash. (Woodinville HS)
Club: Whatcom FC Rangers (Travis Connell)
Coach Showler says: "Reagan is a very strong, feisty, quick forward … she never quits and she'll run through a brick wall for you … she battles and scraps everywhere … she gets a toe in, turns the ball over and finishes the ball well … she's a different type of forward than we have right now, so it will add to the blend … she's an out-and-out goal scorer, she poaches goals and also creates goals … as a defender, she's a nightmare player to play against and as an attacker, she's the player you want on your side."
High School/Club: Quigley is a three-year varsity player for Woodinville High School and 2011 team captain … 2011 Honorable Mention All-KingCo 4A … helped Woodinville advance to the 2010 Washington 4A state quarterfinal round … scored 42 goals in three seasons and led the Falcons in assists both as a junior and as a senior … also competes in track and field and helped Woodinville to a Washington 4A state runner-up finish and a KingCo title in the 4x400m relay … also placed 12th in the state in the open 400m in 2010 … plays for the Whatcom FC Rangers club team … was the 2011 leading scorer for the FC Alliance Gold '93 club team in 2011 and helped lead the team to an RCL Division 2 title, as well as a 2010 National Cup IX U16 Premier regional title … was a team captain for FC Alliance Gold '93 from 2009-11 … served as junior class president in 2010-11 and was voted student body president for the 2011-12 school year at Woodinville … also a member of National Honor Society and Model United Nations.


text:
Nov 11th 2013
Beauty Buff: Short Hair Essentials
Five essentials for creating the perfect pixie. Read More
Five essentials for creating the perfect pixie. Read More
Check out Farmington's new Nordstrom Rack at Station Park Read More
Healthy skin habits that draw the line between dull and dewey skin. Read More
Which size fits your lifestyle? Read More
Orange you excited to get in the Halloween spirit? Read More
A cool weather basic, dressed up or down. Read More
The most popular animal print on your nails, easily done yourself. Read More


text:
By Rob Moseley
Editor, GoDucks.com
Staff continuity at Oregon has rightfully garnered attention as a major key to the Ducks' rise over the years. The current staff is littered with coaches boasting decades of experience with the program, such as Gary Campbell, Steve Greatwood and Don Pellum.
From Jim Radcliffe in the weight room, to Kevin Steil and Kim Terrell in the athletic training suite, several other, less heralded members of the staff also have played a part in that continuity. In that group, count graduate assistant coach Mike Keldorf, who is more than likely entering his final season with the Ducks after methodically working his way up the coaching ladder over more than a dozen years with the program.
Keldorf, a native of Los Angeles, was an undergraduate assistant coach while a student from 2002-06. He then worked as a volunteer assistant and an intern before being named a GA, almost all of those years spent at Pellum's side.
Now in his third year as a GA, the last allowable, Keldorf will pursue a full-time assistant job following this season. He'll do so armed with the wealth of knowledge he accumulated as a valued – if under the radar – member of the program.
"I've always been happy with the fact I've had such a good opportunity to be part of it," Keldorf said. "Seeing how this program has progressed, it's definitely been a privilege."
A former quarterback and linebacker at St. Bernard High in Playa Del Ray, Calif., Keldorf missed his final two high school seasons due to injury. It was then that he was bitten by the coaching bug, while sticking by his team despite the personal setback.
Keldorf's older brother, Chris, was recruited to California during Pellum's brief tenure there, and the two stayed in contact. When Mike expressed interest in attending Oregon, his brother – who eventually played at North Carolina – reached out to Pellum, who had by then returned to the Ducks. Mike participated in a summer camp in Eugene in 2002, and eventually Pellum agreed to take him on as an undergraduate assistant.
His initial duties were solely administrative; Keldorf's first season was spent transferring a hard copy of Oregon's defensive playbook into electronic form. "I didn't know what was on the paper," he said. "I just knew I had to replicate it."
Over the years, Keldorf's role expanded. He spent time on the sidelines, helping Pellum identify personnel groupings the offense was fielding. Eventually he worked his way up into the coaches' box – including a memorable day at Michigan in 2007 – logging the plays called by then-defensive coordinator Nick Aliotti.
The advancement was incremental, as the staff gained faith in Keldorf's abilities. "It's a tight-knit group," he said. "It's not a fraternity, but you don't just break into that role with the lack of experience I had."
That lack of experience contributed to Keldorf's sticking around as a volunteer assistant after graduation, and then as part of the fledgling intern program, from 2008-11. But so too did his emerging talents, as Keldorf gained a mastery of Oregon's defense, and was entrusted to help break down film on opponents.
"There's a lot of people that would like to be a part of our program," Pellum said. "We get inquiries all the time. For a person to be here an extended amount of time, they have to be doing a pretty good job. We depend on them so much, we need them to be able to handle the work. He proved early on he could work."
Keldorf's role breaking down film began with limited special teams review during his undergraduate years. That progressed during four seasons as an intern – two on offense under Campbell, two back on defense – when he'd be assigned specific jobs such as noting a team's tendencies in coverages, or its blitz packages.
The job experience was priceless, for someone who hadn't played in college, and had never been a full-time coach. That more than made up for the limited financial compensation. "It's minimal," Keldorf shrugged, "but it's not that hard to survive in Eugene."
Since he arrived at Oregon, Keldorf's goal had been to become a graduate assistant. He was tantalizingly close as an intern, just waiting for his chance. It finally came in 2012, when he formally joined the defensive staff.
As an intern, Keldorf couldn't actually do any coaching at practices; his work with the scout team was limited to holding up play cards in the huddle before each snap. Now, he and fellow defensive GA Cha'pelle Brown compile scouting reports and run meetings for the scout team, and can provide coaching in position drills.
In his third and final season as a GA, Keldorf can't deny feeling a bit sentimental. That was the case late last season, too, though he could afford to be picky when looking for a job then because the chance for one more season with the Ducks was available. "I didn't know if that was going to be my last year," Keldorf said. "The Oregon State game, when we were singing the fight song, that was a big deal to me."
The 2014 season will almost certainly be the end of the road for Keldorf at Oregon, however – for now, at least, given the Ducks' track record of welcoming former assistants back to the staff after a few years apart. He's soaking up one more season at the side of Pellum, his mentor ever since Keldorf arrived in 2002.
"I don't know why we mesh so well together, other than that I've been a 'yes sir, no sir' guy as long as I've been around him," Keldorf said. "I took the job very seriously, and he appreciated that. I've worked my butt off for him."
Senior linebacker Derrick Malone considers Keldorf a mentor, and said the GA "knows the defense as well as anybody." Malone said Keldorf and Pellum "are like the same person. They've been together for so many years, they know how each other think, they know the common goals they want to achieve, and they feed off each other."
Keldorf also considers Aliotti, Campbell, Greatwood, Scott Frost, John Neal and the last three head coaches – Mike Bellotti, Chip Kelly and Mark Helfrich – as instrumental to his tenure and development with the Ducks.
It's a tenure that's coming to a close, after more than a dozen years contributing meaningfully and without fanfare to Oregon's meteoric rise to national prominence. "As we've always said, 'Next man up,'" Keldorf said. "I've just been happy to be part of this thing."


text:
Varsity Scout Guidebook$10.99Book for Varsity Scouts and their leaders. Includes 27 program features, an annual program planning guide, a team training guide, and a list of requirements for the new Denali award and letter. Appendix includes meeting planning worksheets. Learn More
Troop Leader Guidebook Vol. 1$12.99Recommended for both first-time and experienced Scout leaders, this handbook provides a thorough overview of the responsibilities and rewards of leading a troop. Topics include troop meetings, uniforms and insignia, community service, awards and recognition programs, and much more. Learn More
Senior Patrol Leader Handbook$11.99Completely revised for new patrol leaders, this provides the groundwork for leading troop and patrol activities and being an effective leader at troop meetings and on the trail. Learn More
Sea Scout® Manual$28.99Revised manual is designed to support Sea Scouts Youth members and provides guidance and information in: 1) Ship Organization and Uniform; 2) Ship Operation; 3) Advancement and Recognition; and 4) Safety and Seamanship. Each page is loose-leaf, in a three-hole-punch design that allows you to easily place the pages into a binder or notebook and organize as you like. Also includes a new DVD/CD at the back of the manual providing supporting videos, plus printable forms and articles. Learn More


text:
Prom season is amongst us. High school juniors and seniors are readying to party with glamorous gowns that show off every curve. If you have yet to find the perfect prom dress or procrastinated until now, the Long Island Women's Style Examiner has a selection of affordable prom dresses for the last-minute shopper.
There is no doubt Long Island teens love prom. The fashion trend for prom dresses has been one of glamour, glitz and formfitting gowns that leave little to the imagination. The perfect prom dress is so important that high school social media and smart phone group chats have been dedicated to the fashion item of the night to ensure girls don't show up to prom wearing a replica of someone else's prom dress.
Long Island specialty stores and boutiques charge an exorbitant amount of money for a prom dress that will only be worn once, for a day that is never what one hopes it would be. If you weren't planning on attending prom until now or if the perfect prom dress hasn't caught your eye, then try Bloomingdale's for affordable last-minute prom dresses. While Bloomingdale's is not always synonymous with affordability, its prom dress prices are low as compared to some of the smaller shops throughout Long Island.
The slideshow depicts 12 prom dresses from short to long in an array of colors from $88 to $698 that include some of the top fashion designers such as BCBGMAXAZRIA and Badgley Mischka, with all of the current fashion trends: peplum, cutout, high-low, formfitting and embellishments.
Finish out your last-minute one-stop prom shopping with designer accessories: jewelry, shoes and handbags to match that perfect and affordable prom dress. And not to leave out the young men, Bloomingdale's also offers bow ties, dress shirts, fun cufflinks, colorful socks, leather deck shoes and of course traditional Hugo Boss Metallic Tuxedo Dress shoes.
Suggested Links
- Easter hairstyles perfect for a rainy April
- Wedding hairstyles from backstage at New York Bridal Week
- Get the Coachella looks: Kendall Jenner's nose ring, green hair and edgy nails
- Melissa Rycroft posts pregnancy selfie: Where to buy her maternity maxi dress
- Dress like a movie star: Style tips from George Kotsiopoulos


text:
In this weekly segment, the staff here at HIGH TIMES brings you the best vids to watch after indulging.
50 Cent Dubbed with Jehovah's Witnesses Want Deaf People to Stop Masturbating
Colossians 3:5 says… Yo Shawty/It's your burfday.
Möbius- Memoirs of a Psychonaut
Tripping in the woods—Spring is here!
Tired Meerkat Falling Asleep
Sleepy… or dabbed out?
Firsts: Nan on a Roller Coaster
Teeth and hair: intact.
Powdered Toast Man—Ren & Stimpy
Frank Zappa is the Pope!


text:
Coffee Fest and The Great American Dessert Expo will, however, co-locate in Las Vegas. The trade shows, to be held at the Las Vegas Convention Center June 3-5, will showcase more than 300 booths exhibiting specialty beverage and dessert-related items.
"While we are disappointed that we will not have the desserts showcase in Chicago, we are nonetheless pleased that the Dessert Expo will once again be an integral part of the success of the Las Vegas show," noted David Heilbrunn, show manager for Coffee Fest. "It is only natural that pastries, ice cream, chocolate and dessert wines should share a venue with the best in specialty beverages."
The Great American Dessert Expo was launched in Las Vegas in 2003 by New York-based IMC Events and Exhibitions. IMC also produces the highly successful Kosherfest, an annual trade show for the kosher food industry. For more information, visit www.dessertexpo.com.
Coffee Fest is dedicated to the growth and proliferation of the specialty coffee, gourmet tea and alternative beverage industries. More information can be obtained at www.coffeefest.com or by calling (1)(425) 283-5058.
Paul Kalenian, president of X Café LLC, noted that coffee roasters, juice and beverage distributors and broadline distributors have all embraced this coffee category. "Liquid Coffee Bag-in-Box is the only way to service high volume foodservice accounts that range from health care and convention centers to sports arenas and casinos. Recent advances in liquid coffee extraction, bag-in-box packaging, and liquid coffee dispensers, dubbed 'Ready To Dispense' (RTD) allows the distributor to provide convenience, controlled costs and consistent taste, whether it's for one cup or a thousand cups."
The expansion will give X Café two completely independent production lines, for a total capacity of 12 million lbs. per year. Future plans include a West Coast extraction facility, and satellite plans outside the U.S. negotiations are currently underway for the first international extraction facility.
While the company offers its own 100% Colombian products made Arabica beans, it also offers toll-extraction services for coffee roasters and beverage distributors desiring their own proprietary blend or roast under a private label program.
X Café, P.O. Box 110, Princeton, MA 01541. Tel: (1)(978) 464-8010, Fax: (1)(978) 464-8033.
"The average American drinks two to four cups of coffee a day -- two to four cups of a beloved beverage that just happens to be associated with reduced rates of cancer, diabetes, atherosclerosis, Parkinson's and Alzheimer's diseases, cirrhosis of the liver and suicide," summarized Peter R. Martin, M.D., Director of the Institute for Coffee Studies at Vanderbilt University and Director of the Department of Psychiatry at the Vanderbilt University School of Medicine. Dr. Martin is the world's leading authority on the science of coffee, taking the helm at the Institute for Coffee Studies in 1998 only after doing extensive professional analysis of the scientific literature on coffee, caffeine and health.
Dr. Martin opened the program with an overview of the growing, wide-ranging body of evidence that coffee has significant and measurable benefits for human health. "Coffee frequently was equated with caffeine, thereby not taking into consideration that coffee is a complex mixture of biologically active compounds," said Dr. Martin. "Some compounds in coffee are antioxidants that are beneficial to heart health, others have antidepressive effects, and still others even counteract the effect of caffeine -- all greatly altering the coffee-caffeine equation."
Today, evidence confirms a host of beneficial effects of coffee on health. Among the findings were four major studies from around the world that confirm coffee's protective properties against developing Type II Diabetes. In yet undisclosed findings from the laboratory at Vanderbilt, moreover, a non-caffeine constituent of coffee has been shown to increase by 55% the capacity of the liver to remove glucose from the blood, which may explain the mechanism underlying the Diabetes results.
Also on hand to discuss tips for maximizing athletic performance was Mark Mann, Head Trainer of the Cincinnati Reds professional baseball team. His recommendations for his professional teammates and weekend warriors alike was the benefit of coffee for physical endurance and stamina. The team, he revealed, takes his advice and invariably drinks coffee before heading out on the field.
The event was the effective launch of a new campaign being conducted by the NCA to inform the press and public about coffee's healthful properties. The effort is based on the growing body of significant scientific research, much of it published only in technical scientific and medical journals, that is unveiling substantial health plusses in coffee. This overwhelmingly positive weight of evidence should also serve to help correct old, negative misperceptions about coffee, allowing consumers to increase consumption of all types of coffee, spanning the category. In fact, NCA research in its annual National Coffee Drinking Trends confirmed that health concerns are consumers' leading reported motivator for limiting coffee consumption.
In conjunction with the event, the experts spoke individually with the press, part of an outreach effort aimed at increasing public knowledge of the little known research. Interest already has been expressed by outlets as wide ranging as WFAN sports radio, Reuters international newswire, Bloomberg television and radio, and national women's and fitness magazines.
Terms and Conditions of Website Use.
Privacy Policy.


text:
GUILFORD TWP. — On Neil Hassinger's first day on the job as Medina County sheriff in 1997, he hired Tom Miller, a Brunswick councilman and former police officer.
On Monday, Hassinger will pass the job of the county's top law enforcement official to Miller, who was elected sheriff Nov. 6.
"I'm confident Tom will do a good job," said Hassinger, 74. "I'm sad to go, but now I get to see my grandkids more often."
Hundreds of people showed up to see Hassinger off at his retirement reception Wednesday evening at Buffalo Creek Lodge, 8708 Hubbard Valley Road.
"When I first ran, I said I'd only serve one term," Hassinger told his guests. "And four terms later, I'm finally fulfilling the promise to my wife to retire."
His guests — including several local government officials — thanked him for his service.
"There've been three sheriffs since I was elected," county Commissioner Pat Geissman told him, "but you're my favorite of them all."
County Prosecutor Dean Holman said he was proud to have worked with Hassinger.
"Together, we've prosecuted a lot of bad guys," Holman said. "Sheriff Hassinger has given his life to public service, but now his life belongs to his family."
Hassinger said he is looking forward to retirement.
"I'm hoping to be able to go to more of my grandkids' ballgames, maybe do a little woodworking and traveling," he said.
Hassinger has eight grandchildren, six of whom live in Wadsworth. He moved there from Tiffin when he became a trooper with the Ohio Highway Patrol almost 50 years ago.
He thanked the county community for keeping him around so long, and said they're the reason he plans to stick around.
"I love this county. I'm staying here," he said. "My wife and I might head down to Florida for a couple weeks here and there, but I don't ever want to leave this place."
Hassinger was elected sheriff in 1996, when he defeated four opponents in a landslide in which he took 41 percent of the votes and his closest opponent took only 27 percent.
Since then, Hassinger defeated three other batches of opponents.
"Being sheriff was the hardest job I ever had," Hassinger told his guests. "I wanted to get re-elected, but I also had to do what's right."
Friday is Hassinger's last day in office, which pays $84,065 annually.
"The sheriff is leaving," Sheriff-elect Miller said, "and I, for one, am going to miss him."
Contact reporter Nick Glunt at (330) 721-4048 or email@example.com.


text:
Raaz 3
111 Raaz 3 Articles
Bipasha Basu will not be a part of Darr Sabko Lagta Hai season 2!5 months ago 0
The glamorous actress used to anchor the horror show It is no new news that Bollywood actress Bipasha Basu owes a lot to the horror genre. In fact… Read Article ▶
Raaz Reboot gets a new face – Suzanna Mukherjee!6 months ago 0
Fear finds a new face? Seems so... Raaz is one of those franchises the Bhatts are really proud of. At regular intervals, film from this series make… Read Article ▶
Emraan Hashmi's Raaz 4 to have southern actress Kriti Kharbanda8 months ago 0
Are you excited for the fourth installment of the Raaz series... South actress Kriti Kharbanda will be seen romancing actor Emraan Hashmi in the… Read Article ▶
Harman Baweja doesn't want to work with Bipasha Basu!2 years ago 0
The Love Story 2050 actor opened up about ending his relationship with the Humshakals actress... Harman Baweja and Bipasha Basu are currently taking… Read Article ▶
After Humshakals, will Bipasha Basu disown Creature 3D too?2 years ago 0
The Raaz 3 heroine spoke about some unsavoury moments during the shoot of her previous film... Bipasha Basu, who describes herself as "fiery and… Read Article ▶
Bipasha Basu and Karan Singh Grover to get intimate in Alone!2 years ago 0
The actress was last seen doing an intimate scene with Emraan Hashmi in Raaz 3 Bipasha Basu will soon begin shooting for Alone, in which she returns… Read Article ▶
Yogen Shah
Esha Gupta: Ask me about marriage ten years from now!2 years ago 0
Though the Humshakals actress is in a relationship, she doesn't plan to settle down in the near future She made for a beautiful contemporary looking… Read Article ▶
Yogen Shah
Flops never affect Emraan Hashmi!2 years ago 0
The Raja Natwarlal actor talks about his previous films Ghanchakkar and Ek Thi Daayan Emraan Hashmi's Ghanchakkar and Ek Thi Daayan were abandoned… Read Article ▶
Vikram Bhatt: I'm more at home with 3D now2 years ago 0
The filmmaker has shot four of his films in 3D Director Vikram Bhatt is ready with Creature, his fourth film shot in 3D. He says he feels more at… Read Article ▶
Yogen Shah
Bipasha Basu's Creature 3D release date postponed?2 years ago 1
The film will release on September 12 2014 Vikram Bhatt who's making his third 3D horror film after Haunted and Raaz 3, has postponed the release… Read Article ▶
Yogen Shah
No sex comedies for Esha Gupta and Tamannaah!2 years ago 0
Humshakals actors are not comfortable with the genre! Esha Gupta who appeared in bold avatars in Jannat 2 and Raaz 3, is not comfortable doing a sex… Read Article ▶
Is Bipasha Basu the face of horror in Bollywood?2 years ago 0
After having starred in a number of horror movies like Raaz, Raaz 3, Aatma and Creature, the Humshakals actor has signed her next horror film. Is the… Read Article ▶
What is Emraan Hashmi doing in Salman Khan's Kick?2 years ago 4
The Raja Natwarlal actor is all set to come along with the Jai Ho star... Emraan Hashmi, who is more popular among fans as Hitman Hashmi, seems is… Read Article ▶
Yogen Shah
Is Bipasha Basu calling shots in Harman Baweja's life?2 years ago 0
We hear Bips has asked the producers of Dishkiyaoon to tone down her beau's intimate scenes with co-star Ayesha Khanna in their film. Apparently, the… Read Article ▶
Yogen Shah
Bipasha Basu's movie Creature to have the first ever Indian monster!2 years ago 0
Vikram Bhatt's indigenous creature was created in India and would be called Brahmarakshas Vikram Bhatt is all ready to scare us once again with his… Read Article ▶


text:
Mary (Jacobson) Sikkink
Funeral Service
Mary O. Sikkink
Passed away surrounded by family and friends on January 14th 2012 in Phoenix Arizona after a short courageous battle with lung cancer. She was born April 28th 1941 in Austin MN to Harlan and Geneva (Grimley) Jacobson. Mary graduatedfrom Le Roy - Ostrander high school in 1959, and moved to Rochester to work forWaters-Conley corporation. On June 1st 1963 she married Nathan Sikkink. In 1980 Mary and good friend Marcy Jensen started Decorators II wallpapering service, which remains in business today.
Mary loved spending time with her family, especially her grandchildren. Mary also enjoyed playing cards, and cherished her time with her friends at their winter home in Arizona.
Survived by her husband of 48 years, Nathan, daughter Julie (Tom) Claymon of Rochester, son Michael (Mari) Sikkink of Eden Prairie MN, and grandchildren Morgan, William, Cole Claymon, Samuel and Zackary Sikkink, sister Jeanne (Herman) Miller of Ostrander MN, brother David (Judy) Jacobson of Cresco IA. Friends and family are invited to the Memorial Services at 11:00 a.m. on Saturday January 21st at Gloria Dei Lutheran Church 1212 12th Avenue NW Rochester, MN 55901 There will be a one hour visitation at the church prior to the service.
Ranfranz and Vine Funeral Home 5421 Royal Place NW Rochester, MN 55901 507-289-3600 www.ranfranzandvinefh.com
You have items in your basket. Click here to review and/or checkout
Click the button to generate a printable document containing all condolences submitted
Condolence Booklet
Image: dan / FreeDigitalPhotos.net