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Peulen, Olivier; Dandrifosse, Guy
University of Liege, Department of Biochemistry and General Physiology; Institute of Chemistry, Liege, Belgium
Received July 17, 2003; accepted October 30, 2003.
Address correspondence and reprint requests to Professor Guy Dandrifosse, Institute of Chemistry B6C, B-4000 Liege (Sart-Tilman), Belgium (e-mail: email@example.com).
Supported by the FRFC-IM (contract no. 455–338) and by the FRSM (contract no. 3–4531–96). The Fujisawa Co. donated the FR167653. The authors are supported by the French Community of Belgium.
Objectives: Polyamines are of great importance in biologic processes such as cell proliferation and differentiation. The ingestion of spermidine or spermine by suckling rats induces the precocious maturation of the small intestine. In a previous article, the authors hypothesized that this phenomenon could be mediated by interleukins. This work was performed to examine the role of IL-1, IL-2, and tumor necrosis factor (TNF)- α in the spermine-induced maturation of the small intestine.
Methods: Wistar suckling rats were treated with spermine, FR167653 (inhibitor of IL-1β/TNF-α production), IL-1β/TNF-α neutralizing antibodies, lipopolysaccharide, or IL-2. Intestinal disaccharidase-specific activities, polyamine content, and IL-2 plasma concentration were analyzed. Comparisons were made with untreated control animals.
Results: Spermine-induced maturation of the small intestine was decreased by FR167653 but not by the neutralizing antibodies. Lipopolysaccharide injection induced an increase in disaccharidase-specific activity. IL-2 induced a decrease of the intestinal lactase-specific activity. Spermine administration led to a similar decrease of lactase activity and to an increase of IL-2 plasma concentration.
Conclusions: The authors conclude that IL-1β and TNF-α are involved in the spermine effects on maltase- and sucrase-specific activities and suggest that IL-2 is involved in the spermine-induced decrease of lactase activity.
The polyamines (putrescine, spermidine, and spermine) are polycationic compounds found in high concentrations in all eukaryotic cells (1). Their intracellular concentrations are dependent on the activity of ornithine decarboxylase (ODC), which is one of the rate-limiting enzymes in polyamine biosynthesis, and on the equilibrium between their uptake, excretion, and catabolism (2,3). Polyamines are of fundamental importance in biologic processes such as cell proliferation and differentiation (1,4,5).
During the postnatal development of the rat small intestine, the mucosa undergoes major modifications in its structural and functional properties. At the time of weaning, the large supranuclear vacuoles contained in the enterocytes of the immature ileum disappear (6), and some mucosal enzyme specific activities (SA) change, such as those of lactase, which decreases, and maltase and sucrase, which increase (7). During the same period, the mucosal ODC activity and the intestinal polyamine content increase, indicating the importance of these compounds in weaning (8).
Intestinal maturation, which appears at weaning, is dependent upon genetic, dietary, and hormonal factors (9). We have demonstrated that the ingestion of spermidine or spermine by suckling rats induces precocious maturation of the small intestine (10). The mechanism by which polyamines accelerate or induce intestinal maturation is not yet established. We previously reported that corticosterone is involved in the effects of spermine on intestinal functions (11,12) and that the cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, appear in the plasma of suckling rats between 4 and 8 hours after the first spermine ingestion (13). Moreover, intraperitoneal injection of some of these cytokines induces modifications of disaccharidase SA (13), mainly an increase of maltase and sucrase SA. Cyclosporin A, an activator of T-cells and inhibitor of IL-2 production, reduces the spermine-induced increase of maltase and sucrase SA (14). In this report, we checked whether the inhibition of IL-1β and TNF-α biologic activity reduces the spermine-induced effect on the disaccharidase SA. We also analyzed the role of IL-2 in the spermine-induced maturation of the small intestine. Intraperitoneal injection of lipopolysaccharide (LPS) was used to mimic the effect of spermine ingestion on the immune system. Indeed, LPS injection rapidly induces the production of IL-1β and TNF-α in the plasma (15).
Wistar rats, housed in an air-conditioned room at 23°C with a 12-hour light-dark cycle, were used throughout the study. They were fed with A03 10-mm pellets (Animalabo, Brussels, Belgium) and had water ad libitum. The litters were reduced to 12 pups per lactating mother with free access between mother and pups. The day of birth was designated as day 0. In our experiments there was no body weight difference between male or female pups. No distinction between sexes was made. Because it is well known that the experimental values vary from one litter to another, the comparisons of results were always made between animals from the same litter. All animal experiments were approved by the animal welfare committee of the University of Liege and of the Fonds de la Recherche Scientifique Médicale (FRSM).
All chemicals were purchased from Sigma Chemical Co. (St Louis, MO, U.S.A.) or from Merck (Darmstad, Germany). Immune rabbit serum containing polyclonal antimurine TNF-α was from Genzyme diagnostics (Cambridge, MA, U.S.A.). Ten microliters of serum can neutralize 1,000 units of mouse TNF-α bioactivity in a standard L929 cell cytotoxicity assay. Mouse monoclonal anti-rat IL-1β (clone 38139.11, 500 μg/mL) was from R&D systems (Abingdon, United Kingdom). Neutralization Dose50 was determined to be 10 to 30 μ g/mL in the presence of 4 ng/mL of rat IL-1β using the murine T-helper cell line D10.G4.1. FR167653, an experimental molecule able to inhibit production of IL-1β and TNF-α in vivo (16), was a generous gift from the Fujisawa Co. (Osaka, Japan).
Spermine was dissolved in 50 μL of water (αQ system, Millipore) and administered orally (8 μmol/animal) once a day for 1 (11th postnatal day) or 3 days (11th, 12th, and 13th postnatal days). Control animals were treated in the same way but received only the vehicle. The dose used was almost the same as the amount of polyamines ingested daily by adult rats by the way of solid food (17).
Immune rabbit serum containing the polyclonal antimurine TNF-α, a neutralizing antibody, was injected intraperitoneally (75 μL), diluted with 25 μL of sterile saline (NaCl, 0.9%), or intracardiacally (25 μL), diluted with 25 μL of sterile saline. Control animals were injected in the same way with heat inactivated nonimmune rabbit serum. These injections were performed 2 hours before spermine administration.
Antimurine IL-1β (monoclonal antibody) was injected intraperitoneally (40 μg), diluted in 200 μL of sterile saline. Control animals were injected with the same sterile saline. These injections were performed 30 minutes before spermine administration.
FR167653 was injected intracardiacally (0.3 mg) in 50 μL of sterile saline. Control animals were injected in the same way with the vehicle. These injections were performed 15 minutes before spermine administration.
The dose of anticytokines was based on information available in the literature (16,18). Concerning anti-TNF-α, we used 75 μL of antiserum. In the literature, 50 μL antiserum was injected intraperitoneally before lethal (400 μg) LPS challenge. This treatment significantly protected animals from death. We reduced the dose for intracardiac injection because of direct administration in the blood flow. Concerning anti-IL-1β treatment, we used 40 μg antibody to inhibit a IL-1β plasma concentration of about 6 ng/mL (13). This dose is close to the ID50. Concerning FR167653, we used one bolus injection of 15 μg/g body weight. The literature reported a continuous injection of 0.3 μg/g/15 minutes in animal injected with LPS (1 μg/g body weight). This injection began 15 minutes before the LPS challenge and continued for 4 hours. So the total amount of FR167653 injected was 5 μg/g body weight. This treatment reduced TNF-α and IL-1β concentration to the level observed in untreated animals. Schedules of anticytokine therapy were based of the delay of production of cytokines after spermine administration. TNF-α appeared in the plasma 2 hours and IL-1β 4 hours after the ingestion of spermine. This timing is similar to those observed after LPS injection. We used the same treatment schedule as for LPS inhibition.
Murine IL-2 was injected intraperitoneally (100 μL, 20 μg/kg body weight), once or three times a day for 3 days (11th, 12th, and 13th postnatal days) in sterile NaCl solution (0.9%). Control animals were treated in the same way but received only the vehicle.
LPS from E. coli 026:B6 (10 μg) was injected intra-peritoneally in 100 μL of sterile saline to 11-day-old rats. Control rats received only the vehicle. This treatment was repeated on days 12 and 13.
In the first and second set of experiments, the litter was divided into three groups of four rats and the groups designated as CONT, SPM, and SPM-anti-TNF-α. The SPM group received spermine and an intraperitoneal (first experiment) or intracardiac (second experiment) injection of nonimmune rabbit serum. The SPM-anti-TNF-α rats received spermine and an intraperitoneal or intracardiac injection of polyclonal antimurine TNF-α. Rats in the CONT group received only the vehicles. Animals were killed on the 14th postnatal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In the third set of experiments, the litter was divided into three groups of four rats and the groups designated as CONT, SPM, and SPM-anti-IL-1. The SPM group received spermine and an intraperitoneal injection of sterile saline. The SPM-anti-IL-1 rats received spermine and an intraperitoneal injection of monoclonal antimurine IL-1β. Rats in the CONT group received only the vehicles. Animals were killed on the 14th post-natal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In the fourth set of experiments, the litter was divided into four groups of three rats and the groups designated as CONT, SPM, FR167653, and SPM-FR167653. The SPM group received spermine and an intracardiac injection of sterile saline. FR167653 rats received spermine-vehicle per os and an intra-cardiac injection of FR167653. SPM-FR167653 rats received spermine and an intracardiac injection of FR167653. Rats in the CONT group received only the vehicles. Animals were killed on the 14th postnatal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In the fifth set of experiments, a litter was divided into two groups of four rats; groups were designated as CONT and LPS. The LPS group was injected intraperitoneally with LPS. The CONT group received only the vehicle. Animals were killed on the 14th postnatal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In the sixth set of experiments, a litter was divided into two groups of four rats. Groups were designated as CONT and IL-2. The IL-2 group was injected with IL-2, and the CONT group received only the vehicle. Animals were killed on the 14th postnatal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In the seventh set of experiments, a litter was divided into two groups of four rats. Groups were designated as CONT and SPM. The SPM group received spermine per os, and the CONT group received only the vehicle. Animals were killed on the 11th postnatal day by cervical dislocation; tissues were collected immediately after the sacrifice.
In all cases, after the animals were beheaded, blood was collected from the trunk on edetic acid, and the small intestine was removed and divided into two pieces of equal length. The proximal and distal pieces were respectively named jejunum and ileum. Both were washed in cold NaCl (9 g/L) and homogenized in 4.15 mL/g of cold water with an Ika Ultra-Turrax T8 (Staufen, Germany) equipped with an S8N-8G dispersing element. Homogenates were kept at −70°C until analysis.
The protein content of the homogenates was estimated by the Bradford method (19), using bovine serum-albumin as protein standard.
Sucrase (EC 126.96.36.199), maltase (EC 22.214.171.124) and lactase (EC 220.127.116.11) activities were assayed according to Dahlqvist (20). Enzyme activities were expressed as micromoles substrate hydrolyzed per minute and per gram of intestinal protein (specific activity: SA).
Intestinal polyamine concentrations were measured by reverse phase, high-performance liquid chromatography according to Bontemps et al. (21) and Brown et al. (22).
Plasma IL-2 concentration was assayed by enzyme-linked immunosorbent assay following manufacturer recommendations (OptEIA from Pharmingen).
The results are reported as means with the standard deviation (SD). Statistical analysis was performed using Student t test or one-way analysis of variance (ANOVA) for comparison between groups. Mann-Whitney U or Kruskall-Wallis test was used when heteroscedasticity was suspected.
We analyzed intestinal spermine-induced maturation after the use of several strategies to inhibit the spermine-effect. The disaccharidase SA, markers of intestinal maturation, were analyzed after spermine administration and after a TNF-α neutralizing antibody treatment (Table 1). Spermine administration led to a decrease of the lactase SA and to an increase of the maltase and sucrase SA. Anti-TNF-α treatment (intraperitoneal or intracardiac), before spermine ingestion, prevented neither the lactase SA decrease nor the maltase and sucrase SA increase induced by the spermine ingestion. These observations were similar in the jejunum and in the ileum.
The same parameters were analyzed after spermine ingestion and IL-1β neutralizing antibody treatment (Table 2). Spermine administration induced a decrease of the lactase SA and an increase of the maltase and sucrase SA. Anti-IL-1β treatment (intraperitoneal), before spermine ingestion, did not prevent the lactase SA decrease or the maltase and sucrase SA increase induced by the spermine ingestion. These results were similar in the jejunum and in the ileum.
Disaccharidase activities were analyzed after spermine and FR167653 treatment. As previously described, spermine induced a modification in disaccharidase-specific activities. FR167653 treatment before spermine ingestion did not prevent the spermine-induced lactase SA decrease and maltase SA increase. The same treatment significantly reduced the spermine-induced increase of sucrase SA (Fig. 1).
The effects of LPS on disaccharidase SA are shown in Table 3. In the jejunum, LPS injection (10 μg) induced a significant increase of the lactase, maltase, and sucrase SA. The ileum was not significantly affected by these experimental conditions, except for maltase SA.
Lactase SA, measured in the jejunum of animals treated once a day with IL-2, is significantly lower than in control rats (Fig. 2). However, in the ileum no significant difference was observed between the two groups. Maltase SA estimated in the jejunum of IL-2 treated rats (once a day for 3 days) is significantly lower than that in control animals (Table 4). No significant difference was observed in the ileum of these animals. Sucrase SA was low in both parts of the small intestine and in both experimental groups (Table 4). There was no difference between control and treated groups.
In the jejunum of IL-2 treated rats (3 times a day for 3 days), the protein content expressed as milligrams per gram organ fresh weight was significantly higher (82.622 ± 2.254 v 91.132 ± 3.87; N = 4; P = 0.03) than in the control group. On the other hand, in the ileum, this content was significantly lower (80.880 ± 4.627 v 73.056 ± 1.16; N = 4; P < 0.05) in IL-2 treated rats than in control group. Lactase SA (Fig. 3), estimated in IL-2 treated rats, was significantly lower than in control rats. This observation was noticed in both parts of the intestine. In the jejunum, maltase SA did not vary significantly with IL-2 treatment (Table 4). However, in the ileum, the treatment with IL-2 significantly increased the SA of this enzyme. Sucrase SA was low in both parts of the small intestine and in both experimental groups (Table 4). There was a significant increase of this activity in the IL-2–treated group compared with control group. The intestinal content of putrescine, expressed as nano-moles per gram organ fresh weight or as nanomoles per milligram protein, increased significantly in the jejunum of IL-2–treated rats in comparison with controls (Table 5). In the ileum, the increase did not reach a significant level. In the jejunum, the spermidine content, expressed as nanomoles per gram organ fresh weight or as nano-moles per milligram protein, increased significantly in IL-2–treated rats (Table 5). In the ileum, a significant difference was found only when results were expressed as nanomoles per milligram protein. In both parts of the small intestine, spermine content, expressed as nano-moles per gram organ fresh weight, did not vary between animals from the control and IL-2–treated groups (Table 5). In the jejunum, spermine content, expressed as nano-moles per milligram protein, did not vary between the two groups. However, in the ileum, treatment of rats with IL-2 significantly increased the spermine content expressed as nanomoles per milligram protein (Table 5).
The concentration of IL-2 in plasma was analyzed at the 11th postnatal day in control and spermine-treated rats (Fig. 4). Six hours after the spermine treatment, rats showed an IL-2 plasma concentration significantly higher than that of control rats.
In previous studies, we demonstrated that the oral administration of spermine induces precocious intestinal maturation in suckling rats (10). This observation has been confirmed by other investigators (23–26). Food is the major source of polyamines for humans (27). Spermine content can be as high as 300 nmol/g food. Ingested polyamines appear quickly in the lumen, from whence they are taken up by the gut. Polyamines are initially bound to the apical membrane of enterocytes and subsequently transported across this lipid bilayer via specific carriers. In the case of the transport of polyamines across the basolateral membrane of enterocytes, the mechanism seems to be carrier-mediated (28).
Since then, much work has been done on the mechanism of spermine-induced maturation of the small intestine. Kaouass et al. (29) showed that spermine must be in contact with the intestinal mucosa to induce the maturation of the small intestine. Intravenous and intraperitoneal administrations of this polyamine were ineffective. The same authors (11,12) suggested an indirect action of spermine on the intestinal mucosa by way of glucocorticoids. After bilateral adrenalectomy, spermine did not increase the maltase or sucrase SA. Kaouass et al. (13) proposed that the immune system plays a relay role between the intestinal mucosa in contact with spermine and the adrenal glands. For these authors, secretion of TNF-α, IL-6, and especially IL-1β, explains the effects of spermine on the maltase and sucrase SA. To support this hypothesis, it was shown that spermine induces the maturation of the immune system in the small intestine (30) as well as in the spleen (31,32).
Our results show that spermine-induced maturation is prevented neither by the injection of TNF-α neutralizing antibody nor by the injection of IL-1β neutralizing antibody. These results do not agree with the efficacy of anticytokine therapies shown by other investigators (33). However, we must point out that these neutralizing therapies seem to be useless in some animal models of sepsis (34) and in clinical trials (35). Thus, our results do not allow rejection of the hypothesis of a role of these cytokines in the spermine-induced maturation. In agreement with this point, we report here two different observations: spermine-induced maturation of the small intestine is partially reduced by FR167653, an inhibitor of both IL-1β and TNF-α synthesis, and LPS injection leads to an increase of disaccharidase activities. LPS induces an increase of proinflammatory cytokines (IL-1β, TNF-α) in plasma shortly after its injection (15), and the injection of these cytokines leads to an increase of disaccharidase activities (13) similar to the LPS injection reported here. In addition, the data obtained with FR167653 and LPS confirm that these cytokines are involved in spermine-induced maturation of the small intestine. However, the simultaneous inhibition of IL-1β and TNF-α seems required to inhibit maturation. This result suggests a compensation of the remaining factor when only one is neutralized.
In a recent study (14), we suggested that IL-2 might also be a mediator of the effects of spermine on disaccharidase SA. Treatment of suckling rats with cyclosporin A, an IL-2 transcription inhibitor, drastically reduces the increase of maltase and sucrase SA observed after spermine ingestion. Further evidence supports a role for IL-2 in intestinal maturation: (a) during weaning, the alterations of growth, structure and intestinal functions seem to be mediated by T cells (36); (b) neutralization of the IL-2 receptor reduces intestinal growth (37); (c) during weaning, the IL-2 synthesis increases from almost undetectable to significant secretion in the spleen of the rat (38). Our observations indicate that intraperitoneal injection of IL-2 induces a modification in lactase, maltase, and sucrase SA that is qualitatively comparable to that observed during weaning or after spermine treatment. Our results suggest that IL-2 is mainly involved in the decrease of lactase SA after spermine ingestion because the effect of IL-2 injection is primarily on this SA. This proposal is important because at present few substances can decrease lactase SA, and the mechanisms controlling the decrease of activity of this enzyme at the time of weaning are largely unknown. The substances now recognized to induce a decrease of lactase SA are bombesin (39) and thyroxin (40,41). The effect of thyroxin is contested (42).
To more precisely state whether the effects of spermine on lactase SA are mediated by IL-2, it was necessary to find a measurement of this interleukin in plasma of rats treated with spermine. Treatment with spermine induced an increase of the plasma concentration of IL-2. This increase, although weak, was statistically significant 6 hours after spermine administration. This low level of the increase may be explained by the short half-life of this protein (4 minutes in sera) (43), as well as by its binding to soluble receptors (44) and its sensitivity to proteases (45). The increase occurs at the same time as an even smaller increase of the IL-2 plasma concentration in control animals. This small basal increase seen in controls may be a result of stress at the time of spermine or vehicle administration or to a circadian rhythm. A stress effect on IL-2 secretion is not well supported by experimental data. (46). In humans, the IL-2 plasma concentration increases progressively in the morning to a maximum concentration at noon (47). We also observed a peak concentration in IL-2 four hours after the beginning of the treatment, at 1:00 PM.
Our results obtained after IL-2 injection were not in agreement with one of our previous hypotheses. In a previous work (14), we showed that the effect of spermine on lactase SA was not reduced by cyclosporin A, whereas the effects of spermine on maltase and sucrase SA were strongly altered by cyclosporin A. We suggested that spermine acts on sucrase and maltase SA but not on lactase SA via an IL-2 mediated process. Our current results showed an increase of ileal maltase and sucrase SA after IL-2 administration. Nevertheless, these suckling rats increases were much smaller compared to the marked effect of cyclosporin A. IL-2 by intraperitoneal injection strongly reduced lactase SA, a result not in agreement with our previous hypothesis (14). This difference could be explained by the mechanism of cyclosporin A action which blocks the activation of T cells and consequently induces an inhibition of the transcription of some lymphokines, notably IL-2 (48,49). This inhibition of transcription is caused by an interference between cyclosporin A, complexed with its targets cyclophilin, and calcineurin, a serine/threonine phosphatase depending on calmodulin. The inhibition of calcineurin phosphatase activity by the complex cyclophilin-cyclosporin A prevents the activation of nuclear factors (NF-AT, AP-3, NF-κB) involved in the regulation of the transcription of the IL-2 coding gene (50). These nuclear factors also mediate the transcription of many other genes, the products of which could be involved in the mechanism of spermine action. Therefore, in the observations we made previously (14), we could not exclude a nonspecific mechanism of cyclosporin A on enterocytes or a spread effect of the transcription inhibition of other cytokines.
Intraperitoneal injection of IL-2 (3 times a day for 3 days) modified in an important manner the intestinal metabolism of polyamines, inducing an increase in the content (nmol/mg protein and nmol/g fresh weight) of putrescine and spermidine, mainly in the jejunum. The spermine content (nmol/mg protein) was increased only in the ileum. These results were similar to those observed 3 days after spermine ingestion, especially for spermidine and spermine content (51).
We propose that spermine, in contact with the intestinal mucosa, induces the secretion of some soluble factors of an immune origin. Each of these factors would be at the origin of one or a few biochemical modifications of the intestinal mucosa, e.g., IL-2 would act specifically on lactase SA perhaps via bombesin or thyroxin. The experimental data we collected here allow a better understanding of some observations reported in the literature suggesting that the expression of genes coding for intestinal disaccharidases are independent.
Studies indicate that spermine inhibits synthesis of proinflammatory cytokines (52). Other analyses show that spermine exerts its effects in the gut via a mechanism involving proinflammatory cytokines (IL-1β, TNF-α). These molecules are also involved in some intestinal conditions such as Crohn disease. Moreover, this condition is characterized by a decrease of ODC activity in mucosa (53). Thus, the question of the utility of polyamines in the treatment of intestinal bowel diseases can be raised.
This article has been cited 13 time(s).
Differentiation; Small intestine; Spermine; Suckling; Weaning
© 2004 Lippincott Williams & Wilkins, Inc.
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Inherently Funny
Book describing "the dynamic muscle-toning program for renewed vitality and a more youthful appearance." See also Middle Age.
Added by Tyler on April 16, 2007 | 7 people like this You Like This | Unlike
Facercise... Sounds like a poor excuse for nonstop eating...
Says Jamie H on June 20, 2007
Look at the before and after pics in www.facercise.com !!
Says Jenny C on August 7, 2007
For some strange reason, the title made me laugh.
Says Huh on September 1, 2010
That's the best aswner of all time! JMHO
Says Gloriane on May 10, 2011
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God save us all from those who are intellectually too lazy to be curious...
atszabo · 2011-03-31: 09:54
One of the flaws in your argument is the assumption that power means the "power to change". When knowledge is a commodity, to be traded for the material benefit of the holder, very often it becomes a mechanism to maintain the status quo by joining it. Holders of non-medical doctorates who insist on being called "doctor" are a good example (hello, Baron zu Googleberg).
Knowledge is its own goal, its own power. My life didn't improve after I was awarded by my doctorate (in fact, it deteriorated) but then, I insist on being called by my first name where possible and by "Mr" in all other cases.
I was thatchered in the early 90s and moved to France. My research has absolutely no practical or material application and I rather hope it's been disproved in the 20 years since I undertook it, but my life would have been much poorer without it.
Knowledge is ultimately a selfish joy - until you get a chance to share it.
revenant · 2011-03-31: 11:58
You sure did take some interesting photos of those sessions.
maharba · 2011-03-31: 13:13
i'd second you. the same thought has crossed my mind so many times. but what the heck, we just do what makes us happy don't we?
ColourYourEye · 2011-03-31: 14:05
I think the quote is about specifics - if you learn that you have elevated arsenic levels in your water supply, then you can take legal or political action based on that. But I also see it as personal power - the more you know, the more thought power you have, to make analogies, to understand different fields, places, ideas - which makes life richer and more enjoyable.
Liiisa · 2011-03-31: 18:22
this space is gorgeous. and it is man made. the power of knowledge means to be able to build, fly, communicate
these images are beautiful. and made by you. the knowledge gives you the power to create, travel, play music
lyency · 2011-03-31: 18:38
Awesome depth of field concept! Great tribute and excellent shots. Thanks for sharing!
davidcardona · 2011-03-31: 19:59
oh, I like these pictures so much.
Michael, what would you change being a politician? what would you do with millions? what have you learned since January?
burbulz · 2011-04-02: 07:19
I agree you in most of points... Knowledge is not always power if you do not share it with much practice...
Anyway, I like your photos too :)))
miclaud · 2011-04-03: 07:57
awesome panoramas!
grynteea · 2011-04-06: 16:48
great set!
????? · 2011-04-06: 23:31
interesting effect, super!
hazaj · 2011-04-08: 09:53


text:
Handmade History: Mayan Weaving Demonstrations
>> Click here to watch "Handmade History: Mayan Weaving"
Few people will ever see Mayan weaving live, but the Handmade History: Mayan Weaving Demonstrations held throughout fall term 2013 in the North Quad Commons (Rm 2435) is providing that rare opportunity.
The Handmade demonstrations held by Tati Calixt, RLL lecturer in Spanish, showcase the Nahualá, or backstrap loom weaving technique, common in the Sololá, Huehuetenango, Sacatepéquez, Quetzaltenango and Quiché regions of the western highlands of Guatemala.
For many women in the region weaving has become the lifeline of support for themselves and their families. The Guatemalan Civil War (1960-1996) left many of them without husbands and thrust them into the position of sole breadwinner. As a result several associations of weavers now exist in the country to help these women bring their goods to market.
TRAMA, an association of 400 weavers, is one of the associations that emerged in the aftermath of the genocidal violence. It is also the association that Tati and her students will be working with on the GIEU trip she is planning for summer 2013.
Tati became interested in the various weaving techniques in South America when she taught the 232 Spanish special topics course "Un Museo de la Región Andina" in fall 2007. The course covered several topics related to the Andes Region, which includes Argentina, Bolivia, Chile, Colombia, Ecuador, Peru, and Venezuela, but it was textiles that fascinated her the most.
"I wanted to close the gap between what was written in books and what I had personally experienced, in order to bring the truth to the classroom," Tati said.
Although Tati knitted and did embroidery with her grandmother growing up, learning the varying weaving techniques was unlike anything she had ever experienced before.
"It's a personal journey for me,"Tati said. "Not just learning the technique. I realize now that my connection with threads is bigger than myself. I've come to understand that threads are my origin and weaving is my country: it is the place where I can connect with many pasts, where I can be who I am and who I was."
You can watch Tati give her Mayan weaving demonstration here and be sure to come for a live demonstration on November 29th or December 6th, 1:30-2:45pm in 2435 North Quad.
Interested in Guatemala? Learn more about the upcoming GIEU: Handmade History trip to Guatemala in July 2013 by visiting the CGIS website or contact Tati Calixto, firstname.lastname@example.com.
For information on TRAMA visit TRAMA Textiles.


text:
Hexcel (NYSE: HXL) develops, manufactures, and markets lightweight, high-performance reinforcement products, composite materials and composite structures for use in the commercial aerospace, industrial, space and defense, and electronics markets. Those composites include graphite or carbon fiber composites.
Website: http://www.hexcel.com/
Company Description
Aerospace and wind turbines are major markets. Transportation and sports equipment are developing areas. Hexcel received Silver Performance Excellence Award from Boeing for a fourth consecutive year in 2014.


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I have been crafty forever. I am a serious apparel and handbag sewist but this quilting business is another animal. I am learning a lot and loving it!!!
Polaris - Not Quite
Step-Down Heirloom Scraps
Simple Yellow Batik
Anvil & V Batik
Batik using handmade ...
Batik with Head Gasket ...
Shibori Experiment
Over Dying and Trying ...
First attempt - multiple ...
Dresden Plates
Nine Patch - Greek ...
Log Cabin Action
English Paper Piecing
Stitch and Slash project ...
Take Craftsy with you!
Craftsy Apps for iOS and Android. Read more »


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Women in Health Profession Schools
The health professions have long been characterized by gender disparities. Some professions, such as medicine and dentistry, have historically been dominated by males, while others, such as nursing, have been predominantly female. Over the past several decades, these disparities have narrowed, and in some cases reversed. In 1980–1981, 47.4 percent of pharmacy students were women, while in the fall of 2006, women represented more than 63 percent of pharmacy students. Even in fields where men are still in the majority, the representation of female students has grown. In 1980–1981, only 26.5 percent of medical students were women, compared to nearly one-half (48.8 percent) of students in the fall of 2006. Similar gains have been made in the fields of osteopathic medicine and dentistry, where the most recent data indicate that 49.9 and 44.3 percent of students, respectively, were women, compared to 19.7 and 17.0 percent in 1980–1981.
During the 2006–2007 academic year, female students represented a large majority in graduate public health (70.0 percent) and social work programs (85.6 percent). Nursing, at both the undergraduate and graduate levels, also continues to be dominated by women, although the proportion of students who are female is slowly declining. In the 1980–1981 academic year, 94.3 percent of graduate students in nursing programs were female, while in the fall of 2006, females represented 91.2 percent of graduate students in nursing programs. Women also represent a majority of students studying optometry (64.2 percent) and dietetics (91 percent; data not shown). Comparative data for these programs were not available for the 1980–1981 academic year.


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NASCAR's good, bad and sad
April 28, 2015 It is often said that sport is a microcosm of life, and this past week in NASCAR has reflected the good, the bad and the sad of both… The ever-controversial Kurt Busch took the checkered flag at... more »»
Movers, shakers and record-breakers
April 21, 2015 Let's recognize some significant moves and milestones in Pennsylvania women's athletics. more »»
Goodman Shaffer: Browns trying to repair Manziel's nature
April 14, 2015 ESPN reported over the weekend that Cleveland Quarterback Johnny Manziel has been released from rehab and would begin his quest to return to the football fiel. more »»
Goodman Shaffer: Batch inspires with leadership lessons
April 7, 2015 "Greatness doesn't live here." That was how former Steeler quarterback Charlie Batch opened a thoughtful discussion with an audience of regional business leaders in Johnstown last week. more »»
Kentucky still the talk of the town
March 31, 2015 The NCAA's March Madness has been as entertaining as ever. more »»
Woy has up close view of the madness
March 24, 2015 NCAA basketball came to the CONSOL Energy Center in Pittsburgh for second-and-third round action last week, and amidst all of the madness was Everett native, Ethan Wo. more »»
Goodman Shaffer: St. Patrick's Day signals change in USA, Europe
March 17, 2015 One year ago today, I was celebrating Saint Patrick's Day in the Emerald Isle itself. more »»
PSU alumnus Smith to share international basketball stories
March 10, 2015 The Penn State All-Sports Museum continues its Ellen Perry Speaker Series next week, welcoming former professional basketball star Tyler Smith to the Clemen's Family Theatre. more »»
Tradition special in wrestling
March 3, 2015 They call it the reason for the season. For the best-of-the-best high school wrestlers in Pennsylvania, this week's destination is Hershey's Giant Arena for the PIAA individual championships. more »»
Daytona 500 jumpstarts racing season
February 24, 2015 NASCAR is one sport where the most important event of the year is also the first event of the year. more »»
NASCAR gets drama-free 500 race it needed
February 24, 2015 DAYTONA BEACH, Fla. — It was a bumpy buildup to the Daytona 500, which for days was overshadowed by disputes, drama, an injury to Kyle Busch and the suspension of his older brother, Kurt. more »»
Character big issue at NFL combine
February 24, 2015 INDIANAPOLIS — The questions were similar, and Dorial Green-Beckham had virtually the same response for each one. more »»
Racing and wrestling while waiting for spring
February 17, 2015 Some general observations while watching the snow swirl and listening to the wind howl. n Group qualifying for the Daytona 500 was not entirely a crash and burn, but definitely left many fuming. more »»
Time to celebrate college signees
February 10, 2015 The beginning of February brings a number of significant dates, like Groundhog Day, the Super Bowl, and college football signing day. more »»
Plenty to like, not like about Super Bowl
February 3, 2015 The Super Bowl is in the books, but controversy abounds, and not just about New England's deflated footballs and Seattle's curious last-minute play call. more »»
Celebrating a basketball milestone
January 27, 2015 Their photos are found in high school trophy cases, painted on gym walls, or carefully sealed behind Plexiglass plaques in school lobbie. more »»
Super Bowl season begins
January 20, 2015 Politics has its silly-season; the NFL has the two-week break between the league championships and the Super Bowl. more »»
More rule changes on the way in NASCAR
January 13, 2015 It seems like NASCAR just crowned Kevin Harvick the 2014 champion, but after a brief holiday break, stock car teams (as well as fans) are already looking ahead to 2015. more »»
Boston Marathon trial a somber reminder
January 6, 2015 Jury selection for accused Boston Marathon bomber Dzhokhar Tsarnaev has begun, with the trial expected to begin on Jan. 26. more »»
Goodman Shaffer: Resolutions for a New Year
December 30, 2014 President John F. Kennedy said, "Effort and courage are not enough without purpose and direction. more »»


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Clutch — guitarist Tim Sult, vocalist/guitarist Neil Fallon, drummer Jean-Paul Gaster and bassist Dan Maines — have been making music together for over twenty years, creating rock and roll that falls under different categorizations while defying them all. They built their loyal following during the days of vinyl and thriving major labels, record on their own label, Weathermaker Records, and continue to make loud but remarkably melodic, unique albums. Their latest release, Earth Rocker, is their tenth studio album.
Here's a look back at a 2010 interview with Tim Sult.
In the twenty years that you have been together, what has changed and what has stayed the same?
For the band, not too much. We have the luxury of riding in a tour bus, whereas obviously before this we would drive ourselves in a van, but otherwise the process is very similar, and the songwriting process has always been the same.
When you look at all of your albums, do you consider some of them milestones in the band's career?
I guess our second album had quite a bit of impact on people. It's still our best-selling album. For me, the newest album is always a milestone. But with the second album we found our sound and went into a more experimental direction. I don't know if it continues to be the best-selling. We put it out in 1995, before downloading, and that's a big part of it. Our shows are a lot bigger these days, so obviously the music is getting out there and that's the most important thing.
How have you grown as individuals and musicians over two decades?
We've grown a little as people. We have families. That's a very deep question. Honestly, I don't see a huge difference in myself from 1991 to who I am now. I still want to play shows and I want the band to be successful. I want us to play for as many people as possible. In the past couple of years we've been able to make a living at it.
Your music is described as stoner rock, metal, sometimes as having some punk elements, sometimes hard-core elements. Are any of these accurate?
I'm comfortable with riff rock. Stoner rock or riff rock — both are good. I had never heard the term "stoner rock" until we toured Europe in the 1990s. It always had to do with bands like Kyuss and Fu Manchu, and I'm just fine with that because I like those bands.
So many bands don't make it past the first or second year. Were there ever times when Clutch was close to calling it a day?
Not really. We always had the determination to keep playing music because we never suffered too many setbacks. We were progressing in baby steps and we never had to take steps back and re-examine our lives. We were always moving forward. That's a positive thing and it kept us positive.
How do you continue challenging each other?
We're always listening to different kinds of music, and that sinks into the songwriting process, but to me, the process has not changed from the first album to the last. I guess people see the progression and the fact that a lot of our songs from album to album sound kind of different. But I think that has to do with the production.
This business has changed so much. What's been good and bad in your eyes?
My point of view is that everything has been good with the music industry going down. Obviously, I think it's great. It's all their fault; they ruined it for themselves. The good part is that the only bands out there are the ones that want to do it on their own. Back in the day, everybody got signed and they all got tour support and thought were going to be rock stars. That's why they only lasted one or two albums — because they weren't dedicated to it. They were dedicated to signing a record deal and being rock stars, not to the music, so that weeded out a lot of fake bands. At the same time, we've been around a long time. We were on a couple of major labels and we had distribution early on. Bad or good, it's distribution nonetheless that you don't get when you're not on a major. I'm glad the labels are going down. They are feeding the public generic bands. They're trying to make generic copycat bands that end up sounding like nothing. Real musicians and real music fans have no interest in it. It's an American Idol style in the rock format and that is not what rock fans want to hear. They alienated people who are really into music, as opposed to consumers who are just into one song.
What led you to launch your imprint?
Back in the late 1990s we put out a couple of releases on our own that we only sold at shows and on the Internet. We put them out on River Road Records, but we never tried to find distribution. That was our first foray into doing our own label. We were on another label and it was time. We released three albums on DRT and it was getting worse and worse, so we decided to hire the guy who brought us to Atlantic and who also worked at DRT and get him to manage our label and put out everything on our own. We've been doing it for two years with several releases and a couple of reissues of the old DRT stuff. It has been the greatest thing of all time, but it's not the easiest thing for a new band. It is not 100 percent doable for younger bands. I really am glad we're not starting out now.
You perform a lot of your new songs live prior to recording them. How do you keep that energy and spontaneity in the studio?
I definitely like having the luxury of being able to tour and play the new songs. Fifty percent of the time that's what happens, but hopefully we'll be able to do more with the next album. Playing the songs makes us so much more confident when we record them because we've had time to practice them. A lot of songs on the albums were written before we went into the studio, or while we were in the studio, and by the time we played them live, they had grown and turned into something different. Onstage, we might play the entire second album [Clutch, 1995], but probably not, or all new stuff. We switch the set every night, so you never know what you're going to get.
Is your gear the same live and in the studio?
I always switch my gear. I sell my guitars and buy new ones. But I always have an SG or a Les Paul and Marshall amps. I got a Gibson in the 1980s and I like the natural tone, that woody tone is what I call it. I'm not a processed tone kind of guy.
What is important for you to do as a guitarist when you're playing behind Neil, who is such a powerful vocalist?
I think a lot of it is him placing the vocals around the riffs as opposed to us playing around the vocals. Most of the time the music exists before the vocals and he phrases around the rest, so it's all on him. "Mice & Gods" was music that I put around his voice. I tried to fill in the spots where he wasn't singing and cut through with riffs where there were no vocals. It's not rocket science; it's just rock and roll.
How would you define your playing as the guitarist for Clutch?
I would say that my playing got more rock oriented instead of heavy-chord oriented around early 2000. The Elephant Riders [1998] and Jam Room [1999] had rock influences totally in there. I don't know that my playing has changed much. My solos are a bit more focused, but I'm still doing the heavy riffing and just trying to make something heavy out of the meat-and-potatoes riffs.


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New single-family home sales in the U.S. West rose 80 percent from August 2011 to August 2012, and new home sales have increased in the region, year over year, for seven months in a row. With seven months of sustained year over year growth, new home sales are experiencing some of the most sustained growth seen since 2004, with growth rates reaching a ten-year high. According to today's New Home Sales report, released by the Census Bureau,there were 9,000 new home sales in the Western U.S. during August 2012.
The report, which monitors sales activity for newly constructed houses, reported that in the West, new home sales were up from August 2011's 5,000 new homes sold. Nationwide, sales rose 24 percent, rising from 25,000 to 31,000 during the same period.
The first graph shows monthly new home sales totals for each month since 2003. New home sales in the West were tied at 9,000 for a five-year high during August. New home sales for August have not been higher since 2007.
For the West region:
The second graph shows that new home sales continue to be well below peak levels, although they have begun to slowly move up in recent months.
New home sales peaked during the spring and summer of 2005 and have generally trended downward since. The number of new houses sold in the United States is down 75 percent since the peak of March 2005, and new home sales in the West have fallen 76 percent since sales peaked in the region during March 2004.
The third graph shows the declines in both US and regional totals in new homes for sale.
The number of new homes for sale has also fallen off considerably. The number of new houses for sale in the West has fallen 79 percent since the total peaked during June 2007, and the same total has fallen 75 percent in the US since the number of new homes for sale peaked in the US during August 2006.
As we see signs of growth in new home sales, the number of new homes being offered for sale continues to decline, and is now at the lowest point recorded since the 1990s. This has led to continued declines in inventory.
As a final note, we can also look to the new home inventory. In this case, we calculate inventory by subtracting the number of new home sales in a given month from the number of new homes for sale at the end of the previous month. In the final graph, we see that the inventory is near a ten-year low, and is at 19,000 homes, the lowest point reached since the 1990s. This is good news for owners seeking to sell homes since it suggests that fewer new homes are sitting and waiting to be sold, thus diminishing some of the inventory-driven downward pressure on prices.
This report is just the latest report showing ongoing increases in home sales, while at the same time showing declines in inventory. In the short term, with continued monetary easing, demand for homes looks to continue as inventory wil lonly slowly grow, contributing to ongoing price increases.


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Alaska Conservation Foundation > Experience Alaska > Life in the Great Land > Alaska Notebook: A Well-Behaved Visitor
A cold south wind was blowing off Westchester Lagoon that evening, and it was time for me and my out-of-town guest to stop ogling the Chugach Mountains and start pedaling our bikes home.
As we approached Fish Creek estuary on the coastal trail, a passing biker shouted: "There's a black bear ahead, and it's pretty agitated!"
This is way too cool. I thought. I've lived here 24 years and I've never seen a black bear in my neighborhood. After just two days in Alaska, my friend is getting the treat of a lifetime.
Up where the coastal trail runs along the back yards of Anchorage's rich and famous; we heard a commotion. The teenaged bear was making good time, running across the back lawn of one mansion headed toward town.
Following on the paved trail was Rick Sinnott, the Fish and Game Department's official baby-sitter for wayward urban wildlife.
The bear had just come past Lyn Ary Park while a little League game was under way, but he didn't stop to disrupt proceedings. Earlier at Point Woronzof, the bear had found a temporarily unattended day pack and helped himself to a sandwich.
Aside from that, Sinnott said, "he was pretty well-behaved."
Contributed by Matt Zencey.
This essay first appeared in the Anchorage Daily News, adn.com. Reprinted with permission.
Make a difference. Every dollar invested with the Alaska Conservation Foundation works to protect Alaska's wildlife and wildlands.


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Tis Good to Be a Princess
quiz I got 18 & some junkNovember 15th 2011 2:54 pm
[ Leave A Comment | 2 people already have ]
I found this quiz while visiting my friend Cali's page, and it seemed fun. so here it is. Mom has been busy getting ready for Turkapallooza and has just been busy in general. She was sad when Boots got hit by the car. The Dad gave him a proper burial in the little field down the street by the tracks. Mom is sad to hear about Pounce and Jack the Cat too. So many of us at the bridge. Smitty did not feel good yesterday, and I watched in amusement as Mom attempted to give him a 1/4 pepcid. That cat can do the squirm quite well! All three of us need to go to the vet, we are past due. Mom is trying to decide if it would be lunacy to take all of as at once. I have a little soft carrier that is almost like a purse, and I am good (of course) but Smitty hasn't been in a carrier since a year ago.....so she says if they will give her a discount then we all go, if not, one at a time. Not sure I want tobe first, but I bet I will be cause I am the prettiest. Here is the quiz!
Leave A Comment | 2 people already have
I don't think taking you all to the vet at once would be lunacy...I think it would be suicidal! I had to go to the vet last week,& he made me hiss & growl! Poking & prodding & sticking things up where they don't belong & stabbing me with needles! Don't let them get away with it!
It might be kinda crazy to all go to the vet at once!
Family Pets


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Encyclopedia of Jazz Musicians
Woideck, Carl (Eric)
Woideck, Carl (Eric), tenor and soprano sax, educator, author; b. Cleveland, OH, 23 November 1947. Since 1968, he's played as an invited guest with Bonnie Raitt, Jerry
Garcia, Robert Jr. Lockwood, and Jorma Kaukonen (Jefferson Airplane). He has played professionally in Oregon since 1975. He's played professionally with Joe Sample, Meredith D'Ambrosio, and Nancy King. In 1981, he got his Bachelor of Music (Composition), University of Oregon. In 1989, he got his Master of Science (Interdisciplinary: Music, Education and Ethnic Studies), University of Oregon. He has taught at Lane Community College (years?) and at the U of Oregon both in Eurgene, OR.
(He does NOT play on a Black Saint/Soul Note release of Anthony Braxton orchestral music that was recorded in Eugene around 1987. He's listed in the notes, but had to get a sub for that gig.)
Charlie Parker: His Music and Life (University of Michigan Press, 1996; paperback edition with corrections, 1998)
The John Coltrane Companion (Schirmer Books, 1998)
The Charlie Parker Companion (Schirmer Books, 1998)
Liner notes:
Blue Note, Verve, Mosaic and Prestige


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Instead of using manual, mechanical testing methods, today's cars, trucks, and heavy equipment require computerized troubleshooting, which is often expensive. However, Jake Stucky of Missoula, Montana, has found some cost-saving solutions.
When landslides took out an important Montana road--crucial to the tourist economy--the collective effort of MDOT crews and their consultants and contractors proved to be a success.
Copyright ©
2016 Hanley Wood Media, Inc. All rights reserved.


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Oh wicked spirit born of a lost soul in limbo;
Receive judgement from the garb of the Holy Virgin;
cleansed of worldly impurites;
return to Heaven and Earth.
Oh pitiful shadow lost in the darkness;
Oh evil spirit born of those drifting between Heaven and Earth;
May the thunderous power from the garments of these holy delicate maidens strike down upon you with great vengeance and furious anger
Shattering your loathsome impurity and returning you from whence you came.
Repent you motherfucker!
Scanty and Kneesock's transformation chant:
May the Earth shatter;
May the oceans dry;
May the sun extinguish itself;
Grant upon us the power of our Lord Satan in Hell
We are demons!
High-class Commander Demons!
Scanty: Scanty!
Kneesocks: And her sister, Kneesocks!
Break oh Earth;
Dry up oh sea;
Burn out oh sun;
Grant us power Earthly leaders and gate keepers of Hell
Guide us makers of the underworld!
We are high-class Demon Commanders!
Scanty: I'm Scanty!
Kneesocks: And I'm her darling little sister, Kneesocks!
- Listening to: PSG
- Reading: Higurashi When They Cry
- Watching: nothing
- Playing: nothing
- Eating: nothing
- Drinking: nothing
Just a comment passing by
So awesome! I love that anime!!
i love PSG!
I love PASWG! It is SO cool!!!!
I noticed that the first line if Panty and Stockings english chant was the same as the first line of Hell Girls chant.
On tv tropes PASWG page this chant is listed on the top with 4 links in it. It's signature for this anime's parody style. Notice there's also a Pulp Fiction refference there as well "...and I shall strike down upon you with great vengance and furious anger"
I love All their Chants


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Austin Movers & Services Throughout Texas
Need a mover for the local Austin area or in Texas?
Call Longoria Moving now (512) 491-0888
We are full-service professional Austin movers. We offer many options to help you move! Whether you need someone to move simply a sofa or washer and dryer or you need someone to move your entire 5 bedroom home and packing, we can do it! Longoria Austin Moving Company specializes in moving pianos and antique furniture. Moving from an apartment, condo, townhome, house or small office – we're the professional crew for you.
We will move your furniture carefully and quickly to your new destination. Please give us a call today as we're eager to help you make your move. The moving company Austin residents love. Our friendly and experienced staff will work hard for you by providing amazing customer service with upfront pricing – no surprises or hidden fees on move day! WE PROMISE!
Longoria Moving is fully insured for your protection and registered with TXDoT (#006473448C). Discover moving services Austin area companies and individuals enjoy using. We promise to ensure prompt and on time arrival and promise to take extra care protecting your valuable furniture. We are one of the most trusted Austin apartment movers and home moving companies in Austin, TX
With a passion for customer service and excellence, you won't be disappointed – give Longoria Moving a call to get your free quote. (512) 491-0888


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Following his passing in 2001, the Lars Fossberg Award was created by Lars' family in remembrance of a remarkable man and to acknowledge and encourage the younger up and coming people in our industry who exhibit the attributes and passion that was Lars. The idea for this award orginated with Lars' grandchildren. Hildur's daughter Helen felt very strongly that there should be some way to remember her beloved "bestefor" (Norwegian for grandfather). Hildur's son Steven participated by making the wooden base for the first award.
This award will be presented annually to the manager or supervisor who shows a high degree of initiative and creativity together with the ability to improvise when dealing with the unexpected.
|2016 Jurgen Grau
|2015 Mike Manara
|2014 Allana Williams
|2013 Marlin Van Zandt
|2012 Kevin Fischer
|2011 Flynn Seddon
|2010 Rob Ellen
|2009 Nate Nadja
|2008 Mike Morin
|2007 Jason Hand
|2006 Erik Meertens
|2005 Jeff Davies
|2004 Tim Foster


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Uploaded: 134.87 GB
Downloaded: 21.06 GB
Printable View
Uploaded: 134.87 GB
Downloaded: 21.06 GB
what do you download?
most of my downloads are bigger than 20gb
Albums, movies, TV shows. Idk how it's only 20 gigs, I've definitely downloaded way more than that
the entire series of dragon ball z was 50gb. i cant wait until i finish it so i can delete it
im surprised it only took me one night to download
How do I actually go about taking the interview?
how do you get into the irc?


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Toyota Blue Grass and Central Bank Ashland on opening Saturday highlight new stakes schedule; Race meet enhancements, Breeders' Cup preparations...Read More
3/27/15 11:37am
KEENELAND SPRING MEET OPENS FRIDAY, APRIL 3$1 MILLION TOYOTA BLUE GRASS HEADLINED BY CLAIBORNE BREEDERS' FUTURITY WINNER CARPE DIEM $500,000...Read More
3/26/15 2:45pm
LEXINGTON, KY (March 25, 2015) – Keeneland has announced security measures for horses participating in the $1 million Toyota Blue Grass (G1), a nationally...Read More
3/25/15 12:57pm
LEXINGTON, KY (March 24, 2015) – Firing Line, a graduate of Keeneland's 2012 November Breeding Stock Sale and 2014 April Two-Year-Olds in Training Sale,...Read More
3/24/15 12:40pm
LEXINGTON, KY (March 20, 2015) – Keeneland sales alumni lead entries for this weekend's two preps for the Kentucky Derby Presented by Yum! Brands. Graduates comprise seven...Read More
3/20/15 5:39pm
Keeneland supports the proposed regulation to be considered March 23 by a committee of the Kentucky Horse Racing Commission that would give us the flexibility...Read More
3/20/15 10:46am
New law exempts live wagering from excise tax
FRANKFORT, Ky. (March 17, 2015) – Gov. Steve Beshear today signed into law HB 134...Read More
3/17/15 2:00pm
LEXINGTON, KY (March 16, 2015) – Keeneland sales alum Race Day turned in a gutsy performance to win Oaklawn's Razorback Handicap (G3) by a neck on Saturday....Read More
3/16/15 1:59pm
LEXINGTON, KY (March 16, 2015) – The 2015 edition of the Keeneland Library Lecture Series kicks off March 24 with a unique presentation by Lexington-area actor...Read More
3/16/15 12:11pm
LEXINGTON, KY (March 13, 2015) – Graduates of the Keeneland sales highlight entries for weekend graded stakes. On Saturday, 2015 stakes winners Cassatt and Dame...Read More
3/13/15 11:25am


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About Us
The Medicare Today Initiative:
The Healthcare Leadership Council (HLC), a coalition of chief executives from all disciplines within the healthcare system, launched Medicare Today in November 2004 to reach out to Medicare beneficiaries who needed reliable information on how to get the greatest value from the new Medicare benefits provided by the Medicare Modernization Act (MMA) of 2003. The Healthcare Leadership Council administers the partnership of over 400 national and local organization including National Association of Family Physicians and National Alliance for Hispanic Health. Medicare Today develops innovative tools for use by all partners, commissions research studies, and undertakes earned media efforts and outreach to inform beneficiaries about the value of the new benefits under the MMA. Medicare Today will continue beyond the initial enrollment period to provide continued assistance to beneficiaries and respond to media inquires and opportunities.
- Educate and inform Medicare beneficiaries, the media and the public at large about the new benefits provided through the MMA, including the preventive and prescription drug benefits.
- Bring together partners representing consumers, patient advocates, providers, employers, and others with interest in helping beneficiaries maximize their coverage, to utilize their respective grassroots and communications resources to achieve this shared objective.
- Reach seniors nationwide in personal, meaningful ways through individual or small group contacts in their own communities.
- Disseminate information via trusted local media, organizations, agencies and health influencers (physicians, pharmacists, nurses, hospitals, etc).
- Develop carefully-designed materials and tools that are easy to use and understand to tell beneficiaries exactly what they will gain from the new MMA features.
November 2004.
Recruited and activated 400+ national and local partners.
Fielded more than 3,000 calls through its toll free number.
Field staff
Placed 80 people in 50 states to help educate and enroll beneficiaries.
Trained 175,000 people at 500 local events to assist and enroll beneficiaries in the Medicare drug benefit.
Conducted more than 3,500 education and enrollment events (500 with Members of Congress).
Educated 5.8 million beneficiaries about the Medicare drug benefit.
Enrolled 500,000+ beneficiaries at events or by phone.
Collected more than 800 testimonials from beneficiaries and providers.
National/Local Media
Conducted media outreach resulting in more than 600 million impressions.
PSA Media
Launched broadcast PSA with actress Rita Moreno and Mary Grealy in English and Spanish that produced 365 million impressions. Launched a broadcast PSA as part of Medicare Today's "Get Enrolled" week campaign.
Studies and Surveys
Commissioned five studies — one to explore strategies to encourage beneficiary enrollment in Medicare Part D and four to demonstrate projected and actual savings/costs to beneficiaries under Part D. Conducted two four polls examining beneficiary attitudes about the Medicare drug benefit.
You can also visit www.medicare.gov on the web or call 1-800 MEDICARE (1-800-633-4227) for more information.


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This morning Apple kicked off its annual WWDC developer's conference. As expected, during the keynote address, we saw a
new refreshed line of MacBook Air's make an appearance. The refreshed notebooks now feature the energy efficient Haswell processors from Intel.
The Air's now ship with Core i5 or Core i7 processor and are available with a 128GB or 256GB SSD. The 11.6-inch model is said to be good for 12 hours of use while the 13.3-inch can last up to 9 hours with continual use. The new models also feature 802.11ac Wi-Fi as well as Intel 5000 series HD Graphics.
Both models are available today on Apple's website with the 11.6-inch model starting at $999 for the 128GB version. The 13.6-inch model will begin at $1099 at the 128GB level and increase to $1299 for a 265GB model. At the moment all models feature a 1.3GHz processor, 4GB of RAM and those seeking the higher performance models will have to place a custom order.


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Registrar's Office
Veterans Legislation & Military Status
Grambling State University has been approved by the State Approving Agency for the enrollment of veterans who are eligible for educational benefits under the GI Bill. The Office of Veterans Affairs provides information on educational benefits for veterans attending Grambling State University.
Veterans and eligible dependents should obtain an application for educational benefits from the Registrar's Office located in Grambling Hall, Suite 18 or submit an application at www.gibill.va.gov. Once the application has been submitted to the regional office for approval, the student will be contacted on their eligibility status. If eligibility is declared, the student should obtain a Semester Benefits From our office. This form must be completed every semester that benefits are to be used.
A veteran, dependent of a disabled or deceased veteran, or eligible persons who are in the National Guard or Reserves, must carry at least twelve (12) hours during the Spring and Fall semesters and at least six (6) during the summer sessions to be considered a full-time student. Any change in full-time status must be reported and benefits may be reduced to reflect that change.
Veterans with at least one-year military service may be allowed a maximum of six semester credit hours in health and physical education, in accordance with the recommendation of the Commission on Accreditation of Service Experience. Veterans should submit official copies of service records to the Registrar's Office during the first semester of attendance.
Other services to veterans include work-study, tutorial assistance and vocational rehabilitation. These services are available to Grambling State University students who are veterans and dependents of service-connected disabled and deceased veterans and eligible persons who are in the National Guard or Reserves.


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YOU ARE HERE >> Locations > Colorado > Sterling Regional > Ways to Give > Be a Volunteer > Becoming a Volunteer
How to Become a Volunteer
General Information:
- Sterling Regional MedCenter Volunteers must be 19 years old.
- Interested individuals are encouraged to contact the Volunteer department in advance at (970) 521-3275.
- Due to the in-depth nature of the application and training process as well as the costs involved, we encourage a six-month commitment.
- Volunteers are encouraged to commit to a regular and consistent volunteer schedule.
- The hospital requires each individual to undergo a background screen and TB/immunization titer test before being cleared to volunteer. To be accepted into the Volunteer Program, you must adhere to these requirements.
Application & Orientation Process:
- Complete an application and a consent form for a background check. A background check is required.
- Submit the application with two references to:
Sterling Regional MedCenter Volunteers
615 Fairhurst St., Sterling, CO 80751
- Once the application packet is completed and received by the Volunteer Services Department, these steps will follow:
- An interview with the Director of Volunteer Services
- Background check information will be submitted for clearance.
- If you are a good fit for the volunteer program, we will contact you to come back in for:
- Two-step TB skin/immunization test, ID badge and uniform issued
- Volunteer Orientation (3 hours in length) with designated volunteer.
- At the new employee orientation, you will learn in detail about the requirements for volunteering at SRM, learn the history and mission statement of SRM, and receive important information about Fire Safety, Patient Confidentiality, Infection Control, and Security.
- Position assignment based on needs.
- Site-specific training & competency assessment will be completed.


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Reciprocity can occur at various levels of costs and consequences. Grooming is not critical to survival, but it occurs frequently in many primate species, even among unrelated individuals. It is typically reciprocated by later grooming or other social "favors." In one study of food sharing in a chimpanzee troop, based on over 7,000 observed interactions, exchange was ultimately balanced for each chimp pair (de Waal 1989). Among black hamlet fish of the Carribean (Hypoplectrus nigricans), the exchange involves reproduction. The fish are hermaphroditic; they can both spawn and fertilize. The energy investment in eggs is much greater than in sperm, however, so the reproductive cost to the fish that lays eggs is greater. What fosters reciprocity? Here, any laying of eggs is limited, and successive matings depend on the alternation of male and female roles (Krebs and Davies 1993, p. 285). Here, as elsewhere, repeated encounters allow reciprocity.
As these examples may indicate, arrangements of reciprocity can be fragile, susceptible to cheaters. Each organism cannot always depend on the other to fulfill its end of the "bargain." Such relationships have been modeled using computers for repeated encounters among individuals using various postures of cooperating or "defecting." An individual that "reciprocates" by doing whatever the other individual has done (whether to cooperate or not) seems to be strategically most effective (Axelrod 1984). Such simulations underscore the possible relevance of social interactions, addressed in what follows.
© 2008 EVOLUTIONofMORALITY.net


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Tucker & Dale vs Evil Movie Reviews
User reviews on Tucker & Dale vs Evil
I really liked this comedy and I highly recommend seeing it in the theaters. I did not expect this film to be this good but it surprised me in a very good way. The comedy even has a message that all people are different and they should not be lumped up into regional stereotypes. The cast of the film is amazing and I have never seen them anywhere before but they did an excellent job and I hope to see them more. The film is clever, funny and the timing is perfect, i had a great time watching it.
This is a comedy about two friend Tucker and Dale who get attacked by preppy college kids, the film is directed by Eli Craig and stars Tyler Labine, Alan Tudyk and Katrina Bowden. I really liked this comedy, I had so much fun watching it and definitely recommend seeing it in the theaters. I thought that I will never see a good comedy again in my life, I mean the stuff that Hollywood comes out with is either disgusting or full of incredibly stupid cliches. this film was like a breath of fresh air and it made me laugh so hard. I loved the idea of the film and the situations were very funny, I also loved Tyler Labine and Alan Tudyk, they are super funnny and have a great chemistry together.
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- Home
- Campus
- About Sexual Violence
About Sexual Violence
- Sexual Violence Prevention and Support
- About Sexual Violence
- Policies and Procedures
- Reporting
- Support Resources
- Prevention Strategies
- LGBT Individuals and Sexual Violence
- Healthy Sexuality
- Information for Faculty and Staff
- Title IX at Macalester
Campus Center 243
What is sexual assault?
Sexual assault is any form of unwanted sexual contact obtained without consent and/or obtained through the use of force, threat of force, intimidation, or coercion. It is a criminal act that can be prosecuted under Minnesota state law, as well as under the college's policies.
What is sexual harassment?
In general, behavior is considered sexual harassment when:
Submission to such conduct is made explicitly or implicitly a term or condition of an individual's employment or academic success or
Submission to or rejection of such conduct by an individual is used as the basis for employment or academic decisions affecting such individuals or
The conduct has the purpose or effect of unreasonably interfering with an individual's work or academic performance or creating an intimidating, hostile, or sexually offensive working environment.
What is stalking?
Stalking is best defined as unwanted attention, harassment or pursuit that causes fear. Many behaviors can be called stalking and most often victims know their stalker.
What is dating violence?
Dating violence is a pattern of behaviors used to exert power and control in a dating, romantic or sexual relationship.
College Policy
Sexual Assault is a serious form of sexual misconduct that falls under Macalester College's Sexual Misconduct policy. The policy outlines the college's zero tolerance policy toward sexual assault, provides guidance for survivors of sexual assault, outlines the college's disciplinary response to alleged incidents of sexual assault, and identifies the relevant people within the college responsible for managing the policy and programs associated with it. Macalester's policy complies with relevant state and federal statutes.


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Use delight in a sentence
- People went dizzy with wonder and delight over it. [5]
- Phanes was radiant with delight; Croesus full of care and thought. [10]
- Biberli had noticed with delight that his master had not sought as usual to detain him. [10]
- I have questioned whether their delight was not like that of the Spartans in the drunken antics of their Helots. [6]
- Of one such visit Howells wrote: It was the delight of such a visit that kept Clemens constantly urging its repetition. [5]
- Heliers, a delight to the quiet eye. [11]
- Suddenly she came to her feet with a cry of delight, and ran out towards the horse. [11]
- But he seemed to delight in the pain he had caused. [9]
- She had wished to arouse his attention, his approval, his delight in her singing. [10]
- She silently accepted the water he offered her, and drank it with delight, to the very dregs. [10]
- The trumpet sounded, the people broke out in shouts of delight, the tilting began. [11]
- When he had registered it, and she sang a few passages from it, what an exquisite delight awaited him! [10]
- The Judge, at random, summoned up a good one, to the delight of the audience. [9]
- Just as the praetor had concluded his report Argus set up a howl of delight and Antinous came into the room. [10]
- With a cry of delight Virginia threw it over her shoulders and ran to the long glass between the high windows. [9]
This page helps answer: how do I use the word delight in a sentence? How do you use delight in a sentence? Can you give me a sentence for the word delight? It may also be related to school part-time universities, private school, kindergarten school private education, special education study, teachings, degree, and lessons.
Example sentences with the word delight, a sentence example for delight, and delight in sample sentence.


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Defensive Line Duo Of Reid, Catapano Pick Up Additional Honors
Coming off their All-America seasons, defensive linemen Caraun Reid and Mike Catapano added an additional honor to their stellar 2012 campaigns. Both were honored by the College Football Performance Awards (CFPA).
Reid earned the 2012 CFPA FCS Defensive Tackle Award, while Catapano earned the 2012 CFPA FCS Elite Defensive End Award. Catapano is also coming off a strong showing at the East-West Shrine Bowl, where he was mentioned several times among the players whose draft stock rose significantly during the week.
Both Reid and Catapano, each of whom earned unanimous All-Ivy League distinction this year, became Princeton's first football All-Americas since 2006, when senior punter Colin McDonough earned third-team honors. Together, Reid and Catapano helped change the direction of the Princeton football program, and they led the Tigers to their biggest victory turnaround in more than two decades.
Reid, who earned preseason All-America recognition after his first-team All-Ivy season last year, was selected to the 2012 All-America second team. While playing inside and often facing double-team blocking schemes, he still placed in the Top 10 in both sacks (sixth) and tackles for loss (ninth) in the Ivy League. Reid was at his best in a shutout of Brown during Week 5; he recorded four tackles for loss, 2.5 sacks and a safety in a 19-0 victory over the Bears.
"Caraun Reid may not have the same numbers as other players, but the coaches know his value on the defense," Surace said. "Other guys have easier jobs because of the focus placed on Reid. He plays at such a high level, and he took over some games."
Catapano, a third-team All-America honoree who earned the 2012 Bushnell Cup as the Ivy League Defensive Player of the Year, led the Ivy League with 12 sacks and ended the regular season ranked second in the Football Championship Subdivision with 1.2 sacks per game. He ranked second in the Ivy League in tackles for loss with 15.5, which was only a half tackle off the League lead, and ranked ninth nationally in that category. The two-year co-captain ended the season with 41 tackles, and he had five games with at least two tackles for loss, as well as five games with at least five tackles. His 12 sacks were the most for a single season at Princeton since David Ferrara '00 recorded 12.5 during the 1998 season.
"Even more than his play on the field, which was dominant, Mike's biggest impact on the program was the leadership he brought every day," said head coach Bob Surace, a finalist for the Eddie Robinson Award as the National Head Coach of the Year. "His work ethic was a model for our locker room, and his impact on our team will be felt for years to come."


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On Jun 19, in an interview with Fox News' Martha MacCallum, Jay Sekulow of the ACLJ vowed to subpoena every government agency that communicated with Lois Lerner, in regards to the alleged IRS scandal. Such agencies include: the Federal Election Commission, the Department of Treasury and the Department of Justice (Jay Sekulow with Martha MacCallum). This warning came after Lerner and six other IRS employees claimed that a computer glitch caused them to lose all of their 2009-2011 emails. The House Oversight and Government Reform Committee requested the emails, to help investigate who was involved in the illegal targeting of Tea Party groups during the 2012 election.
Sekulow is one of several lawyers representing multiple conservative, non- profit groups whose 501 (c) statuses were held hostage by the IRS during the previous election. The IRS scrutinized these groups by searching for keywords, such as: Tea Party, patriots, Christian, and conservatives, in hopes to silence them during the 2012 election. Sekulow made his plan very clear in dealing with Lerner, the IRS, and the other parties involved," she may have lost her emails, but people received those emails. So, the people that received them are going to need to turn them over. […] If they eliminated the evidence and can't produce them, it's deemed admitted under federal law. […] They also violated the Federal Records Act. So, […] you've got a series of violations here (Jay Sekulow with Martha MacCallum)."
The investigation began when Lerner publicly admitted the IRS' inappropriately targeted Tea Party groups. Since then, the House Committee has undergone an uphill battle to investigate the alleged scandal. Lerner has pleaded the Fifth Amendment twice before hearings before the House Committee, even though she allegedly waived her rights by admitting no wrong doing. Sekulow called Lerner's actions criminal (Jay Sekulow with Martha MacCallum).


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Click here to print the obituary below
Wendell E. Denbow
CASTLE HILL - Wendell E. Denbow, 52, passed away Jan. 2, 2013, at a Bangor hospital. He was born July 19, 1960, in Lubec, the son of Frank B. and Eva M. Denbow.
He worked for many years as a millwright and welder. Wendell enjoyed riding his Harley, and loved playing his guitar, Harmonica and drums, "a one man band." He loved gardening, loved children, and loved spending time with family and friends.
He is survived by his wife, Theresa (LaCombe) Denbow of Castle Hill; a son, Dustin Scott Denbow of Old Town; a foster son, Gregory Carney of Rockland; two daughters, Jessica Seeley and her husband, Jamie, of Lubec and Brittany Denbow and her significant other, Eric York, of Presque Isle; a brother, Frank Denbow Jr. and his wife, April, of Wells; two sisters, Loretta Moulton and her husband, Elmer, of Cape Neddick and Raymah Lyons and her husband, Wallace, of Meddybemps; four grandchildren, Ethan, Isabelle and Zachary Seeley and Dustin Scott Denbow Jr.; many special nieces and nephews, that he loved dearly, as well as special relationships with his brother and sisters-in-law. He was predeceased by his parents; and a sister, Marilyn Denbow.
Friends may call 6-8 p.m. Monday at Duncan-Graves Funeral Home, 30 Church St., Presque Isle. Funeral services will be held 1 p.m. Tuesday, Jan. 8, at Mapleton Baptist Church with the Dr. Rev. Kenneth Phelps officiating. Spring interment will be at Wendell E. Denbow Family Cemetery, Lubec. Online condolences may be expressed at
Funeral Home
Duncan Graves Funeral Home
30 Church Street
Presque Isle, ME 04769
Published in BDN Maine on Jan. 5, 2013


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From 0 ratings
Plant type
Evergreen climber
Flower colour
Skill level
This is distinctly different from most other clematis. In early spring it is completely covered in small creamy white flowers that have very small petals but large bunches of stamens, giving the plant a whiskery look. As it is a very small growing species, it is often grown in a pot or in a rock garden without any support so it forms a neat mound. It can also be trained onto a low wall, but needs tying in place since it does not climb naturally. In cold districts it is best grown in a pot and moved under cover in winter, where it remains until after the flowers are over.
Family: Ranunculaceae
Genus: Clematis
Species: x cartmanii
Cultivar: Joe
Plant type: Evergreen climber
Flower colour: White
Foliage colour: Mid-green
Feature: Flowers
Sun exposure: Full sun, Partial shade
Soil: Well-drained/light, Clay/heavy, Chalky/alkaline, Dry
Hardiness: Hardy
Skill level: Expert
Height: 90cm
Spread: 60cm
Be the first reader to review the Clematis x cartmanii 'Joe' Forsteri Group clematis!


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Father: Joseph BONHAM b: ABT 1798 in Grayson, Virginia, USA
Mother: Tabitha L RUSSELL b: ABT 1804 in Grayson, Virginia, USA
Marriage 1 Samuel Jackson BISHOP b: 02 MAR 1826
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Rainbow Serpent Festival bitten by council rules
Just a week before it opens its gates, the annual Rainbow Serpent festival has been cancelled.
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Lexton's popular annual dance festival, the Rainbow Serpent Festival has been cancelled.
Just a week before it was meant to start, the Pyrenees Shire Council has refused to issue the festival a permit to operate, citing inadequate emergency management standards.
The Mayor of the shire Michael O'Connor says rather than being a last minute decision, discussions to get the festival "over the line" have been ongoing since mid-last year.
The company originally engaged to provide emergency and medical management pulled out of the festival and despite calling a meeting of all concerned, council couldn't verify the capacity of the replacement provider.
"At the end of the day the emergency services organisations, together with council did not have confidence that the emergency management plan could be implemented" Cr O'Connor said.
The festival has been running for more than 15 years and contributes hundreds of thousands of dollars to the local community each year.
Cr O'Connor says there's not much that can be done to resurrect the festival for this year and from council's perspective it won't go ahead.
He says that he's not personally happy about the outcome because it's so lucrative for the region, however "as a councillor, as the Mayor of the shire with that much broader perspective, I'm quite comfortable with that decision."
The festival organiser Frank Venuto acknowledgese that the last minute change of emergency management provider was disruptive but he says it wasn't intentionally disorganised.
"The situation was brought upon us without any warning and we just did the best we could to deal with it and at the meeting at the time that was specified we weren't able to convince one of the authorities in particular that the service provider would be adequate."
He admits that their earlier preparation for council wasn't up to scratch or on time, but he says they worked hard to meet the standards and "it's all a bit of a shock to us... that we've taken such a step backwards."
The festival organisers say they are seeking legal advice on their options.
Eight thousand tickets have already been sold for the festival and between 10 and 15 thousand people are expected to attend.
Local businesses and community groups rely heavily on the income from the Rainbow Serpent Festival.
Jane Briody is a community organiser and the landholder where the festival is held.
She says between 30 - 40 thousand dollars is raised every year through the 24 hour barbecue that runs in conjunction with the festival.
This year a proportion of the money raised was to go towards the Lexton Cemetery Trust to produce a map of its grounds and a database of records.
She says they will now have to cancel their plans because of a lack of funds.
"It's not just Lexton that's going to lose out on this, the township of Amphitheatre do jobs, Waubra do jobs, and not forgetting the township of Beaufort and the businesses and what the huge losses are going to be for them."
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Want one of the best hairstyles of the year? Get inspired by these celebrities' short bangs, pixie cuts, angled bobs, bouncy curls and more
The only thing better than a bob is an angled bob. It complements oval- and heart-shaped faces—and is a fresh, edgy take on a classic.
Short bangs do take maintenance, but there's no prettier way to channel Audrey Hepburn.
Short hair can be versatile: with strands smartly slicked back, a cropped cut moonlights as a faux-updo.
Classic side-swept bangs are perfect for the all-grown-up girl-next-door.
A pretty twist and bouncy curls give the pop queen a glamorous, Old-Hollywood vibe.
A classic bob flatters the actress's face shape and helps her stand out in the gorgeous and blonde crowd (although she didn't exactly need help with that).
Kidman's long, layered cut is polished and simple, proving that sometimes less is more.
The How I Met Your Mother star garnered attention (and plenty of compliments, we're guessing) with a pretty flapper-inspired chop.
A pixie cut takes Williams from "pretty girl" to "serious style-setter."
If you have the stick-straight strands to pull it off, a sharply-layered style is super chic.
Growing out long bangs? McAdams doesn't sweat it—she just disguises them with a cute center-part.
Barrymore embraces her curls (and ditches the ombré hair color) with a gorgeous layered 'do.
Blunt-cut bangs are a fresh update for Bullock.
Choppy layers in Pfeiffer's waves create an overall vibrant, youthful look. The result? Farah Fawcett's iconic hair meets the 21st century.
Graduated layers give some life and movement to Stone's deep side part. Bonus: This looks good on just about everyone.
A sharp, single-layer bob is a risk, but one that comes with the payoff of looking instantly polished and put-together—even with a pink tint.
So Berry's pixie isn't exactly new, but we couldn't resist this flattering and playful faux hawk.
The long, grown-out bob is one of the best cuts...ever. Leave it to the girl who started "the Rachel" to set off the trend.
From her newly-svelte figure to a set of lash-grazing, face-flattering bangs, Jennifer Hudson is clearly on a style roll.
The Glee actress chopped off her blonde locks to match her character's rebellious turn, but we consider it sweet and sophisticated off-screen.
Gussy up your go-to hairstyle with a few of our favorite hair accessories.
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First Published Fri, 2011-12-16 17:22
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Five New and Fun
Attractions in Las Vegas
Ah, Las Vegas – the ultimate gambling getaway. With its garish glitz and gaudy glamour, it can be easy to become swallowed up in the stereotypical Vegas stay.
But besides the obvious, what else is there to do? What's up and coming and new to do there? We've got the hook up on the latest and greatest Las Vegas has to offer, so grab a pen and paper and take notes.
Music, Comedy and Circus
Audiences will experience 'thrills and chills' as they witness unbelievable feats right before their very eyes. Absinthe just celebrated its one year anniversary and 500th show milestone on April 1, 2012. It gets even more bizarre when they do the show in the dark!
Absinthe show times are Tuesday, Thursday-Saturday at 8:00 p.m. and 10 p.m., and Wednesday and Sunday at 8:00 p.m., with no show on Monday at Caesar's Palace. However, the schedule is subject to change without notice. Absinthe will take place in the dark for all performances on the dates of April 30, May 1, May 7, May 8, May 14 and May 15.
For groups of 10 or more, please call 702-785-5394 / 866-633-0195 or email@example.com. For additional information on ABSINTHE, visit www.AbsintheVegas.com.
Celebrity Burlesque
On April 16, Peepshow starring Holly Madison, located at Planet Hollywood, will celebrate its third
Full of high style and impressive choreography, Peepshow provides enticing fun in a 'glamorous enchanted adult playground.' The 30th annual Las Vegas Review-Journal voted the show to have the "Best Showgirls."
The night prior to April 15, Peepshow will participate in the fight against AIDS with the third annual Las Vegas Broadway Bares, this year titled "Barelesque: Do You Have the Dare to Bare?" The performers will take the stage to raise money for Broadway Cares/Equity Fights AIDS, one of the nation's leading industry-based, nonprofit AIDS fundraising and grant-making organizations.
Peepshow will perform a special show to present other Strip show performers including dancers from Matt Goss, The Pussy Cat Dolls, Jubilee!, Divas Las Vegas and many others, with a special performance by PEEPSHOW's male lead singer Josh Strickland.
Excellence in Performance
The Smith Center for the Performing Arts is a $150 million performing arts complex in downtown Las Vegas that recently opened on March 10, 2012. With a focus on diverse entertainment, the Smith Center is home to Broadway touring productions, dance, music and theater from around the world.
The events, organized by genre on the website, consist of Broadway, classical, contemporary, dance, family, special attractions and cabaret jazz.
The box office is open for ticket sales Monday-Friday 10 a.m.-6 p.m. and Saturday 10 a.m.-2 p.m. On show days, the office will remain open three hours before the first curtain and one hour after the last curtain time. Those interested in buying tickets can also call the office at 702-749-2000 or online at firstname.lastname@example.com.
Some of crime's biggest names are a part of the museum such as Al Capone, Dion O'Bannion, George
The Mob Museum
The Las Vegas Mob Museum opened on February 14, 2012 on Stewart Avenue. This modern day museum is one of a kind in its experimental and interactive aspect. Guests can use interactive touch screens and other methods to explore law enforcement and crime tools.
Visitors have the opportunity to shoot a simulated tommy gun, listen to real FBI surveillance tapes on wiretapping equipment and take part in FBI weapons training. The museum also includes some iconic features like the wall from the Valentine's Day Massacre.
The Mob Museum is open Sundays through Thursdays 10 a.m. to 7 p.m. and Fridays and Saturdays 10 a.m. to 8 p.m. Admission is $18 for adults ages 18 and over; $12 for children ages 5 to 17 and students ages 18 to 23 with ID; $14 for seniors, military, law enforcement and teachers; and $10 for Nevada residents of all ages. Tickets are available to purchase by phone by calling 702-229-2734.
The Neon Museum
The Neon Museum opened in May 2012 and exhibits Las Vegas' most iconic flashy signs. The mission of the museum is to "collect, preserve, study and exhibit" the best neon signs of the city for "educational, historic and cultural enrichment," according to the website.
Office hours are Monday-Friday 11 a.m.-5 p.m. Guests can visit their website at neonmuseum.org or contact staff at firstname.lastname@example.com.
Malea Ritz is a former editorial assistant at GoNOMAD and a graduate of UMass. She lives in Boston, MA.
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: Las Fallas, One Crazy Festival! By Jean Miller Spoljaric The AFallasA is a four-day and four-night


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These last couple of months have involved a lot of birthdays and gift-giving. Whenever I give gifts I always like to try and get creative with the packaging to make the whole experience that much more extra special. I try and find old papers from around my home that I can recycle and objects that (…) Read more
Tagged: gift-giving
The Gift Every Girl Loves To GetDec 14, 2012
When you give a girl lingerie as a gift her face lights up, it's because it is so pretty and delicate. Right now I'm in love with our Single Hipster Gift Package. It's perfect for a stocking filler, and because of the bobble packaging it comes in, you can hang them it on the tree and tell her "there's a gift (…) Read more
What's The Best Gift You've Ever Given?Nov 28, 2012
I love giving gifts; I love the surprise of a gift and the smile that fills the person you're giving it to. That's why Christmas and birthdays are some of my favorite occasions. Whether it's something small or something more extravagant, it's always a lovely gesture to give someone a gift. The gifts I love the most (…) Read more
From Our Store Girls: The Perfect GiftsNov 14, 2011
It's the season for giving gifts, and we just launched our Holiday Boutiques last week full of great gift ideas. It can be a little overwhelming when it comes to picking out the perfect present, so we decided to ask our store ladies across the country what would be on their wishlist this year! Haley, (…) Read more