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SEATTLE - Indoor track is back in the Dempsey and if today's UW Indoor Preview is any indication, the 2014 season will bring another batch of meets heavy on the milestones. The Dempsey witnessed its 100th sub-four-minute mile this afternoon in just its 13th year of operation, and also saw five meet records go down as the track warmed up in a hurry in the season opener.
Many of the Husky freshmen who made their collegiate debuts today were not even in grade school when former Husky Eric Garner led four runners under the hallowed 4:00-mile barrier on March 2, 2002. Since then, the Dempsey has turned into an indoor distance running mecca, with dozens of Olympic caliber athletes dotting the list of four-minute-milers in the building. Fittingly, American mile record-holder Alan Webb was competing at the UW Indoor Preview today, though the No. 100 honor went to Patrick Casey, a professional with the Oregon Track Club, who ran 3:58.06 today.
The story of the day for the Dawgs was a sensational debut from junior college transfer Diamara Planell Cruz in the women's pole vault, as she found herself taking jumps at the Washington indoor school record in her first D-I meet. Planell Cruz, a Puerto Rico native and the California State Community College champ the past two seasons, vaulted over five consecutive heights on just one attempt, making 13-11 ¼ to zoom right to No. 2 on the Husky top-10 list. She then took three tries at 14-3 ½ which would have inched ahead of the school record, but came up short today.
Though it's early in the season, Planell Cruz already moves to No. 3 in the NCAA this season in the vault. The mark she cleared has always qualified for the NCAA Indoor Championships in past years, but it's too early to tell how the top-16 will develop.
The presence of Pac-12 rivals USC, Stanford and Oregon along with several elite pros fresh off Team USA last year, made for a quality opener, according to Head Coach Greg Metcalf.
"From top to bottom, including and excluding our team, there were great performances in the sprints, the jumps, the distances, the throws; this was a great track meet today," Metcalf said.
Planell Cruz was one of a number of Huskies to impress in their first time in the Dempsey, while veteran Dawgs were often able to pick off right where they left off last spring.
Pac-12 Freshman of the Year Chris Williams had a third-place finish in the 60-meter hurdles early in the day, running 8.12 seconds in the final, while junior Howard Lao was first in his heat and fifth overall in 8.18 seconds. Freshman Devin Liebel from Buckley, Wash. also just missed the final, running 8.32 seconds in the prelims. In the women's hurdles, sophomore Kimberly Stueckle edged under her freshman PR by .01 seconds, running 8.82 to take ninth overall.
Sophomores Quadelle Satterwhite and Travis Marshall looked strong in their openers at 100-meters, Satterwhite taking fifth in the final in 6.83 seconds and Marshall sixth in a PR of 6.92. In the women's 60m, junior Haley Jacobson was just off her PR, going 7.71 seconds.
One of the best openers in recent memory from a true freshman in the field events came from Richland, Wash. native Elizabeth Quick, who pole vaults as well as high jumps. She cleared a solid 5-5 in the high jump, and then was one of three Husky women's vaulters to clear 12-11 ½. Senior Logan Miller and sophomore Kristina Owsinski also made that bar, good starting points for their seasons.
The men's high jump saw another impressive debut, as Joseph Knight stepped right in and cleared 6-10 ¼, less than a month into his time on the squad. Knight, who played basketball and track last year at Pomona Pitzer, attended RooseveltHigh School. He tied with senior A.J. Maricich for fourth in the high jump today.
The first meet of the year often comes with some unusual distances that help set the stage for upcoming races. A 600-meters and 1,000-meters were both on the schedule today. Eleanor Fulton and Amy-Eloise Neale both looked strong in the thousand, Fulton running 2:47.28 to take fourth overall in a strong field, and Neale closing fast for 2:47.88 and sixth-place. Izaic Yorks was very impressive in the men's 1,000, nearly catching Nike OTC Elite athlete Tyler Mulder but getting past three Stanford runners to finish second in 2:22.14. Redshirt freshman Blake Nelson was also a strong sixth in 2:23.13.
In the men's mile, freshman Jonathan Stevens donned the uniform for the first time and clocked 4:12.64, and sophomore Jacob Smith also ran a 4:12.80. Freshmen Sumner Goodwin and A.J. Yarnall also had solid debuts at the 3k, going 8:28.28 and 8:29.59.
It was a good start for several returning Huskies with postseason aspirations. Sophomore Jax Thoirs was second in the men's pole vault at 17-4 ½, and J.J. Juilfs was third at 16-10 ¾. Kasen Covington was third in the triple jump going 49-feet, 3-inches.
The Husky throwers had several strong opening marks as well in the shot put and the weight. In the men's shot, Cal Poly transfer Brian Hutchison placed fifth with a toss of 53-7 ½, and freshman Dan Boyden out of Arlington High School checked in with a mark of 51-6 ¼ for sixth. Sophomore Jack Scheideman had an eight-foot PR in the weight throw at 55-3 ¾.
Sophomore Bev Coleman was fourth in the women's shot put with a PR of 44-5 ¼, and Hannah Sherrill was fifth with a personal-best of her own at 43-5 ¾. Alyx Toeaina was also seventh at 43-4 ¼. Sophomore Carolyn Gravelle also had a weight throw best of 46-9 ½.
"On the women's side, Elizabeth Quick had a great showing in the vault and the high jump, that was great for a freshman," said Metcalf. "Eleanor Fulton and Amy-Eloise Neale I think were two quality performances in the thousand. Diamara, for her to jump as high as she did, that should get to the show, so that was easily the highlight."
"On the men's side, Quadelle Satterwhite and Travis Marshall, I liked the way they competed today. Kasen Covington had a solid start to his year in the triple jump. Joe Knight looked great in the high jump and Jax and J.J. had good starts in the vault. The men's shot putters look as dangerous as they have in years, so there was a lot to like today, but a lot of work to do starting with the next day of practice.
The first Dempsey facility record to fall this season came in the women's 60-meter dash final, where Jasmine Todd of Oregon ran 7.20 seconds to break the old mark by .01. Meet records came in the women's 60m, the women's 400m, the men's 200m, the men's 3,000m, and the men's 60m hurdles.
Washington will be back in the Dempsey in two weeks for the UW Invitational, which takes place Friday and Saturday, Jan. 31-Feb. 1.


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red velvet cookies
These are a favorite in our house because they're quick
and so so good!
1 box red velvet cake mix
1/2 cp butter
8 oz package of cream cheese
1/2 cp powdered sugar
Beat butter and cheese adding powdered cake mix slowly.
Mix until blended.
Form balls and roll in sugar.
Bake at 350 for 8-10 mins.
7 comments:
mmmm! i want some now! where do you come up with these creative quick recipes!ReplyDelete
A friend of mine made some red velvet cookies, similar to this, for a party the other weekend. I ate 8 of them. In a row.ReplyDelete
Yum! We love red velvet. Always reminds me of our wedding!ReplyDelete
these look so delicious! i've had red velvet cupcakes, but never cookies. i must try these.ReplyDelete
xo Alison
Mmm...red velvet anything is perfection!ReplyDelete
P.S. Love the new blog header.
Hey you could get some green and orange m&ms roughly crushed up in them and they'd almost look like hamburger patties :OReplyDelete
- NikkiMay 25, 2010
oh my gosh, yum!ReplyDelete
thank you for your comments!
if you have any questions please email me via the 'contact' link.

subset: commoncrawl


text:
Professor Chris A O'Callaghan
|Research Area:
|Technology Exchange:
|Bioinformatics, Cellular immunology, Computational biology, Crystallography, Flow cytometry, Microscopy (Confocal), Protein interaction and Transcript profiling
|Scientific Themes:
|Immunology & Infectious Disease and Physiology, Cellular & Molecular Biology
|innate immunity, molecular immunology, protein-protein interactions, surface plasmon resonance, crystallography and ligand identification
|Web Links:
CLEC-2 is present on platelets and immune cells and the colours highlight the charged areas of the m ...
Our group is studying immunity and inflammation with a disease focus on atherosclerotic vascular disease. We are particularly interested in understanding the mechanisms underlying the immune/inflammatory aspects of the disease process with a view to identifying new approaches to treatment. We use a wide range of techniques including molecular and cellular biology, immunological assays, fluorescence techniques, recombinant protein production, structural biology, next generation sequencing and epigenetic analysis.
|Professor Richard J Cornall FMedSci FRCP
|Centre for Cellular and Molecular Physiology
|University of Oxford
|United Kingdom
|Pamela Bjorkman
|California Institute for Technology (Caltech)
|United States
|Steve Watson
|University of Birmingham
|United Kingdom
|Professor Paul Klenerman
|Experimental Medicine Division
|University of Oxford
|United Kingdom
|Johannes Eble
|University of Frankfurt
|Professor Benedikt M Kessler
|Target Discovery Institute
|University of Oxford
|United Kingdom
|Professor Paul Moss
|University of Birmingham
|United Kingdom
|Del Besra
|University of Birmingham
|United Kingdom
PLoS Genet, 11 (4), pp. e1005061. Read abstract | Read more2015. Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of loci are unknown. Recent studies have suggested that many causal GWAS variants influence disease through altered transcriptional regulation in disease-relevant cell types. We explored changes in transcriptional regulation during a key pathophysiological event in CAD, the environmental lipid-induced transformation of macrophages to lipid-laden foam cells. We used a combination of open chromatin mapping with formaldehyde-assisted isolation of regulatory elements (FAIRE-seq) and enhancer and transcription factor mapping using chromatin immuno-precipitation (ChIP-seq) in primary human macrophages before and after exposure to atherogenic oxidized low-density lipoprotein (oxLDL), with resultant foam cell formation. OxLDL-induced foam cell formation was associated with changes in a subset of open chromatin and active enhancer sites that strongly correlated with expression changes of nearby genes. OxLDL-regulated enhancers were enriched for several transcription factors including C/EBP-beta, which has no previously documented role in foam cell formation. OxLDL exposure up-regulated C/EBP-beta expression and increased genomic binding events, most prominently around genes involved in inflammatory response pathways. Variants at CAD-associated loci were significantly and specifically enriched in the subset of chromatin sites altered by oxLDL exposure, including rs72664324 in an oxLDL-induced enhancer at the PPAP2B locus. OxLDL increased C/EBP beta binding to this site and C/EBP beta binding and enhancer activity were stronger with the protective A allele of rs72664324. In addition, expression of the PPAP2B protein product LPP3 was present in foam cells in human atherosclerotic plaques and oxLDL exposure up-regulated LPP3 in macrophages resulting in increased degradation of pro-inflammatory mediators. Our results demonstrate a genetic mechanism contributing to CAD risk at the PPAP2B locus and highlight the value of studying epigenetic changes in disease processes involving pathogenic environmental stimuli. Hide abstract
Bioinformatics, 30 (9), pp. 1302-1304. Read abstract | Read more2014. PeaKDEck: a kernel density estimator-based peak calling program for DNaseI-seq data.
Hypersensitivity to DNaseI digestion is a hallmark of open chromatin, and DNaseI-seq allows the genome-wide identification of regions of open chromatin. Interpreting these data is challenging, largely because of inherent variation in signal-to-noise ratio between datasets. We have developed PeaKDEck, a peak calling program that distinguishes signal from noise by randomly sampling read densities and using kernel density estimation to generate a dataset-specific probability distribution of random background signal. PeaKDEck uses this probability distribution to select an appropriate read density threshold for peak calling in each dataset. We benchmark PeaKDEck using published ENCODE DNaseI-seq data and other peak calling programs, and demonstrate superior performance in low signal-to-noise ratio datasets. Hide abstract
Am J Med Genet A, 158A (12), pp. 3196-3200. Read abstract | Read more2012. Floating-Harbor syndrome and polycystic kidneys associated with SRCAP mutation.
Floating-Harbor syndrome (FHS) is a rare genetic disorder recently shown to be caused by mutations in the Snf2-related CREB-binding protein activator protein gene (SRCAP). It comprises three key clinical features of characteristic facies, expressive and receptive speech impairment and short stature. We report on a patient with this syndrome associated with early adult-onset hypertension and bilateral polycystic kidneys. Family screening for polycystic kidney disease was negative and mutations in polycystic kidney disease 1 and 2 genes (PKD1 and PKD2) were absent. Sequencing of the SRCAP gene demonstrated a de novo mutation matching one of the known FHS-associated mutations. The patient required treatment with anti-hypertensives and will require lifelong renal monitoring. We suggest this patient's presentation may be due to the pleiotropic effects of SRCAP mutations. Further, the protein encoded by SRCAP is known to interact with CREB-binding protein, the product of the gene mutated in Rubinstein-Taybi syndrome, which is associated with renal abnormalities. A literature review of the renal findings in patients with Floating-Harbor syndrome identified another patient with possible polycystic kidneys, two patients with early onset hypertension, and a young patient with a ruptured intracranial aneurysm, which can be a feature of classic adult polycystic kidney disease. Collectively, these findings suggest that all patients with Floating-Harbor syndrome should undergo regular blood pressure monitoring and screening for polycystic kidneys by ultrasound at the time of the FHS diagnosis with imaging to be repeated during adulthood if a childhood ultrasound was negative. Hide abstract
J Biol Chem, 287 (6), pp. 4299-4310. Read abstract | Read more2012. NF-κB regulates MICA gene transcription in endothelial cell through a genetically inhibitable control site.
Endothelial cells form a barrier between blood and the underlying vessel wall, which characteristically demonstrates inflammatory damage in atherosclerotic disease. MICA is a highly polymorphic ligand for the activating immune receptor NKG2D and can be expressed on endothelial cells. We hypothesized that damaged vessel walls, such as those involved in atherosclerosis, might express MICA, which could contribute to the vascular immunopathology. Immune activation resulting from MICA expression could play a significant role in the development of vascular damage. We have demonstrated that TNFα up-regulates MICA on human endothelial cells. The up-regulation is mediated by NF-κB, and we have defined the regulatory control site responsible for this at -130 bp upstream of the MICA transcription start site. This site overlaps with a heat shock response element and integrates input from the two pathways. We have shown that in atherosclerotic lesions there is expression of MICA on endothelial cells. Using lentivirus-mediated gene delivery in primary human endothelial cells, we were able to inhibit the MICA response to TNFα with a truncated HSF1 that lacked a transactivation domain. This highlights the potential for transcription-based therapeutic approaches in atherosclerotic vascular disease to reduce immune-mediated endothelial and vessel wall damage. Hide abstract
J Biol Chem, 286 (27), pp. 24208-24218. Read abstract | Read more2011. Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.
The human C-type lectin-like molecule CLEC5A is a critical macrophage receptor for dengue virus. The binding of dengue virus to CLEC5A triggers signaling through the associated adapter molecule DAP12, stimulating proinflammatory cytokine release. We have crystallized an informative ensemble of CLEC5A structural conformers at 1.9-Å resolution and demonstrate how an on-off extension to a β-sheet acts as a binary switch regulating the flexibility of the molecule. This structural information together with molecular dynamics simulations suggests a mechanism whereby extracellular events may be transmitted through the membrane and influence DAP12 signaling. We demonstrate that CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. We used blotting experiments, surface analyses, glycan microarray, and docking studies to investigate the ligand binding potential of CLEC5A with particular respect to dengue virus. This study provides a rational foundation for understanding the dengue virus-macrophage interaction and the role of CLEC5A in dengue virus-induced lethal disease. Hide abstract
Blood, 115 (14), pp. 2947-2955. Read abstract | Read more2010. CLEC-2 activates Syk through dimerization.
The C-type lectin receptor CLEC-2 activates platelets through Src and Syk tyrosine kinases, leading to tyrosine phosphorylation of downstream adapter proteins and effector enzymes, including phospholipase-C gamma2. Signaling is initiated through phosphorylation of a single conserved tyrosine located in a YxxL sequence in the CLEC-2 cytosolic tail. The signaling pathway used by CLEC-2 shares many similarities with that used by receptors that have 1 or more copies of an immunoreceptor tyrosine-based activation motif, defined by the sequence Yxx(L/I)x(6-12)Yxx(L/I), in their cytosolic tails or associated receptor chains. Phosphorylation of the conserved immunoreceptor tyrosine-based activation motif tyrosines promotes Syk binding and activation through binding of the Syk tandem SH2 domains. In this report, we present evidence using peptide pull-down studies, surface plasmon resonance, quantitative Western blotting, tryptophan fluorescence measurements, and competition experiments that Syk activation by CLEC-2 is mediated by the cross-linking through the tandem SH2 domains with a stoichiometry of 2:1. In support of this model, cross-linking and electron microscopy demonstrate that CLEC-2 is present as a dimer in resting platelets and converted to larger complexes on activation. This is a unique mode of activation of Syk by a single YxxL-containing receptor. Hide abstract
Biochemistry, 48 (46), pp. 10988-10996. Read abstract | Read more2009. The platelet receptor CLEC-2 is active as a dimer.
The platelet receptor CLEC-2 binds to the snake venom toxin rhodocytin and the tumor cell surface protein podoplanin. Binding of either of these ligands promotes phosphorylation of a single tyrosine residue in the YXXL motif in the intracellular domain of CLEC-2. Phosphorylation of this tyrosine initiates binding of spleen tyrosine kinase (Syk) and triggers further downstream signaling events and ultimately potent platelet activation and aggregation. However, it is unclear how a single YXXL motif can interact efficiently with Syk, which usually recognizes two tandem YXXL repeats presented as an immunoreceptor tyrosine-based activation motif (ITAM). Using bioluminescence resonance energy transfer, coimmunopreciptitation, recombinant protein expression and analytical gel filtration chromatography, surface plasmon resonance, Western blotting, multiangle light scattering (MALS), and analytical ultracentrifugation, we show that CLEC-2 exists as a non-disulfide-linked homodimer which could allow each Syk molecule to interact with two YXXL motifs, one from each CLEC-2 monomer. Hide abstract
Biochem J, 411 (1), pp. 133-140. Read abstract | Read more2008. Renal cells activate the platelet receptor CLEC-2 through podoplanin.
We have recently shown that the C-type lectin-like receptor, CLEC-2, is expressed on platelets and that it mediates powerful platelet aggregation by the snake venom toxin rhodocytin. In addition, we have provided indirect evidence for an endogenous ligand for CLEC-2 in renal cells expressing HIV-1. This putative ligand facilitates transmission of HIV through its incorporation into the viral envelope and binding to CLEC-2 on platelets. The aim of the present study was to identify the ligand on these cells which binds to CLEC-2 on platelets. Recombinant CLEC-2 exhibits specific binding to HEK-293T (human embryonic kidney) cells in which the HIV can be grown. Furthermore, HEK-293T cells activate both platelets and CLEC-2-transfected DT-40 B-cells. The transmembrane protein podoplanin was identified on HEK-293T cells and was demonstrated to mediate both binding of HEK-293T cells to CLEC-2 and HEK-293T cell activation of CLEC-2-transfected DT-40 B-cells. Podoplanin is expressed on renal cells (podocytes). Furthermore, a direct interaction between CLEC-2 and podoplanin was confirmed using surface plasmon resonance and was shown to be independent of glycosylation of CLEC-2. The interaction has an affinity of 24.5+/-3.7 microM. The present study identifies podoplanin as a ligand for CLEC-2 on renal cells. Hide abstract
Immunology, 121 (4), pp. 439-447. Read abstract | Read more2007. Regulation of ligands for the activating receptor NKG2D.
The outcome of an encounter between a cytotoxic cell and a potential target cell depends on the balance of signals from inhibitory and activating receptors. Natural Killer group 2D (NKG2D) has recently emerged as a major activating receptor on T lymphocytes and natural killer cells. In both humans and mice, multiple different genes encode ligands for NKG2D, and these ligands are non-classical major histocompatibility complex class I molecules. The NKG2D-ligand interaction triggers an activating signal in the cell expressing NKG2D and this promotes cytotoxic lysis of the cell expressing the ligand. Most normal tissues do not express ligands for NKG2D, but ligand expression has been documented in tumour and virus-infected cells, leading to lysis of these cells. Tight regulation of ligand expression is important. If there is inappropriate expression in normal tissues, this will favour autoimmune processes, whilst failure to up-regulate the ligands in pathological conditions would favour cancer development or dissemination of intracellular infection. Hide abstract
J Biol Chem, 282 (5), pp. 3165-3172. Read abstract | Read more2007. The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.
The human C-type lectin-like molecule CLEC-2 is expressed on the surface of platelets and signaling through CLEC-2 causes platelet activation and aggregation. CLEC-2 is a receptor for the platelet-aggregating snake venom protein rhodocytin. It is also a newly identified co-receptor for human immunodeficiency virus type 1 (HIV-1). An endogenous ligand has not yet been identified. We have solved the crystal structure of the extracellular domain of CLEC-2 to 1.6-A resolution, and identified the key structural features involved in ligand binding. A semi-helical loop region and flanking residues dominate the surface that is available for ligand binding. The precise distribution of hydrophobic and electrostatic features in this loop will determine the nature of any endogenous ligand with which it can interact. Major ligand-induced conformational change in CLEC-2 is unlikely as its overall fold is compact and robust. However, ligand binding could induce a tilt of a 3-10 helical portion of the long loop region. Mutational analysis and surface plasmon resonance binding studies support these observations. This study provides a framework for understanding the effects of rhodocytin venom binding on CLEC-2 and for understanding the nature of likely endogenous ligands and will provide a basis for rational design of drugs to block ligand binding. Hide abstract
Immunity, 15 (2), pp. 201-211. Read abstract | Read more2001. Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.
NKG2D is a potent activating receptor on natural killer cells, T cells, and macrophages. Mouse NKG2D interacts with two cell surface ligands related to class I MHC molecules: RAE1 and H60. We used soluble versions of NKG2D, RAE1, and H60 to characterize their interactions. RAE1 and H60 each bind NKG2D with nanomolar affinities, indicating tighter binding than most cell surface immune interactions, but NKG2D binds to H60 with approximately 25-fold higher affinity than to RAE1. RAE1 and H60 compete directly for occupancy of NKG2D, and, thus, NKG2D can be occupied by only one ligand at a time. The NKG2D-H60 interaction is more temperature dependent and makes greater use of electrostatic interactions than the NKG2D-RAE1 interaction. The distinct thermodynamic profiles provide insights into the different molecular mechanisms of the binding interactions. Hide abstract
Eur J Immunol, 30 (12), pp. 3552-3561. Read abstract | Read more2000. Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
HLA-F is a human non-classical MHC molecule. Recombinant HLA-F heavy chain was refolded with 2-microglobulin to form a stable complex. This complex was used as an immunogen to produce a highly specific, high-affinity monoclonal antibody (FG1) that was used to study directly the cellular biology and tissue distribution of HLA-F. HLA-F has a restricted pattern of tissue expression in tonsil, spleen, and thymus. HLA-F could be immunoprecipitated from B cell lines and from HUT-78, a T cell line. HLA-F binds TAP, but unlike the classical human class I molecules, was undetected at the cell surface. HLA-F tetramers stain peripheral blood monocytes and B cells. HLA-F tetramer binding could be conferred on non-binding cells by transfection with the inhibitory receptors ILT2 and ILT4. Surface plasmon resonance studies demonstrated a direct molecular interaction of HLA-F with ILT2 and ILT4. These results, together with structural predictions based on the sequence of HLA-F, suggest that HLA-F may be a peptide binding molecule and may reach the cell surface under favorable conditions, which may include the presence of specific peptide or peptides. At the cell surface it would be capable of interacting with LIR1 (ILT2) and LIR2 (ILT4) receptors and so altering the activation threshold of immune effector cells. Hide abstract
Mol Cell, 1 (4), pp. 531-541. Read abstract | Read more1998. Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
The crystal structure of the nonclassical human class lb MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class l leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells. Hide abstract
Nature, 391 (6669), pp. 795-799. Read abstract | Read more1998. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. We constructed tetramers in which recombinant HLA-E and beta2-microglobulin were refolded with an MHC leader-sequence peptide, biotinylated, and conjugated to phycoerythrin-labelled Extravidin. This HLA-E tetramer bound to natural killer (NK) cells and a small subset of T cells from peripheral blood. On transfectants, the tetramer bound to the CD94/NKG2A, CD94/NKGK2B and CD94/NKG2C NK cell receptors, but did not bind to the immunoglobulin family of NK cell receptors (KIR). Surface expression of HLA-E was enough to protect target cells from lysis by CD94/NKG2A+ NK-cell clones. A subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones. Only the HLA alleles that possess a leader peptide capable of upregulating HLA-E surface expression confer resistance to NK-cell-mediated lysis, implying that their action is mediated by HLA-E, the predominant ligand for the NK cell inhibitory receptor CD94/NKG2A. Hide abstract


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Oct 25, 2010 9:28 AM
Ok so....what's not to love about the The North Face Animagi Jacket ($149)? It's black, shiny and The North Face. Plus it's warm and super flattering on the body. Umm....we'll take one in every color.
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text:
From OncoLog, February 2012, Vol. 57, No. 2
Palliative Care May Offer Survival Benefits
By Bryan Tutt
Recent studies indicate that palliative care, which has been shown to improve quality of life in patients with advanced cancer, may also help patients live longer.
Patients with cancer or any life-threatening disease face a broad array of physical, spiritual, emotional, and financial problems. "Palliative care has a body of knowledge that can help patients, families, and even the primary care physicians treating those patients cope with problems related to debilitating chronic disease," said Eduardo Bruera, M.D., a professor in and chair of the Department of Palliative Care and Rehabilitation Medicine at The University of Texas MD Anderson Cancer Center.
Benefits of palliative care
For cancer patients, the most noticeable benefit of palliative care (also called supportive care) is the relief of physical symptoms such as pain, fatigue, lack of appetite, nausea and vomiting, or shortness of breath. "We have demonstrated consistently that when people are seen by the supportive care team in addition to their oncologist, they feel better," Dr. Bruera said.
But palliative care is not limited to pain management; it includes counseling and other services that can ease the emotional and spiritual distress of patients and their families.
Palliative care may also offer a financial benefit to patients and their families. Dr. Bruera said that patients who receive palliative care concurrently with cancer treatment and continue to do so after treatment options have been exhausted are less likely than those not receiving palliative care to be given a costly and unnecessary escalation of care in emergency rooms or intensive care units at the end of life.
These benefits, plus a survival benefit, were documented in a 2010 study reported in the New England Journal of Medicine. In the study, patients with metastatic non–small cell lung cancer who received palliative care had better quality of life, were less likely to receive aggressive care at the end of life, and had a longer median survival duration than those who did not receive palliative care.
Similar studies to determine whether palliative care will lengthen survival for patients with other types of cancer are under way at MD Anderson and other centers, and Dr. Bruera said preliminary data from these studies are promising. He hypothesized that the survival benefits from palliative care likely result from a combination of factors. "If patients feel better emotionally and physically, they are able to continue their cancer treatment," Dr. Bruera said. "Another point that has been shown very clearly for other diseases is that untreated physical and emotional distress can shorten lives. If a patient has untreated pain, fatigue, depression, and nausea, there is a chance that he or she will die of complications from that continued stress."
For these reasons, Dr. Bruera encourages oncologists to refer patients to a palliative care center at the first sign of physical or emotional distress.
Outpatient care
A referral for palliative care can take place at any point in the disease or treatment process because palliative care can be given in conjunction with chemotherapy or radiation therapy. To ensure that all patients have access to palliative care services, MD Anderson has both inpatient and outpatient palliative care centers.
Outpatient palliative care is important because many cancer patients—even those with incurable disease—continue living at home and working while undergoing treatment.
"Our model is based on collaborating closely with the primary oncologist early in the treatment of the disease," Dr. Bruera said. "In fact, more than 80% of the patients seen at our palliative care center are receiving active cancer treatment. Ours is a program in which patients' overall physical and emotional care is integrated with their cancer treatment."
What's in a name?
Dr. Bruera, who served on the committee that drafted the World Health Organization's definition of palliative care in 1986, said that although palliative care has always been intended for any patient with a serious chronic or life-threatening illness, the misconception that palliative care is primarily a transition to end-of-life care persists.
In 2007, MD Anderson conducted a survey of its oncologists and mid-level providers and found that the name "palliative care" was a deterrent to their referring patients who had early stages of cancer or who were undergoing active treatment. To more accurately reflect its services, the Palliative Care and Rehabilitation Medicine Center changed its name to the Supportive Care Center.
Since the name change, the number of referrals has increased by about 40%, and patients arrive about a month and a half earlier in their treatment process than they did before. "We believe these improvements are because clinicians feel more comfortable referring their patients to a place called supportive care, which is not closely associated with the end of life," Dr. Bruera said.
Patient-centered care
Patients being treated at MD Anderson can be referred to the Supportive Care Center by their oncologist. During a patient's first visit to the outpatient clinic at the Supportive Care Center, the patient, usually accompanied by family members, goes directly to a comfortable hotel-style room; there is no waiting room. Together, the patient, the patient's family, a nurse, and a palliative care physician identify any physical, emotional, spiritual, social, and financial problems and establish a personalized care plan that addresses these issues.
"No one comes to the center with just one problem," Dr. Bruera said. "Patients usually come with seven or eight problems, and during the initial visit we establish a plan to deal with every one of them. Our care is multi-disciplinary. It includes doctors, nurses, counselors, social workers, chaplains, and in many cases physical and occupational therapists." Several of these professionals typically see the patient during the initial visit.
The Supportive Care Center is organized so that the physicians, nurses, and other professionals come to the patient, who remains in the room where he or she can relax. "We try to minimize the number of places the patient has to visit," Dr. Bruera said.
Follow-up visits to the Supportive Care Center are scheduled on days when the patient is coming to MD Anderson for other treatment or tests. The patient is encouraged to call the Supportive Care Center between visits if he or she has questions or needs support. "We get 30–40 phone calls every day from our patients to discuss how they're feeling," Dr. Bruera said.
A win-win situation
In addition to maintaining contact with the patient, the palliative care physician consults with the patient's oncologists to ensure that supportive care services complement the patient's cancer treatment.
"In the past, there was the thought that a referral for palliative care might be some sort of trade-off in which patients would have better quality of life but shorter survival, perhaps because their treatment would be less aggressive," Dr. Bruera said. "But now we've seen that this is not true. Rapid and early access to supportive and palliative care might be a win-win situation in which patients benefit from reduced emotional, spiritual, symptom, and family distress as well as longer survival."
For more information, contact Dr. Eduardo Bruera at 713-792-6084.
Home/Current Issue | Previous Issues | Articles by Topic | Patient Education
©2014 The University of Texas MD Anderson Cancer Center


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Cody ChesnuTT gets his Marvin Gaye on something serious on this live rendition of "That's Still Mama." If this doesn't stir something inside, we don't know what will – whew. So smooth.
Develops and implements integrated marketing strategies, digital, social, event and experiential programs for consumer brands, leveraging music and culture.
Cody ChesnuTT gets his Marvin Gaye on something serious on this live rendition of "That's Still Mama." If this doesn't stir something inside, we don't know what will – whew. So smooth.
October 30 is near, which means Cody Chesnutt's sophomore album, Landing On A Hundred, is finally about to drop. You've heard "Til I Met Thee" and "That's Still Mama" over the last couple months, and now you can breathe easy thanks to the NPR First Listen stream of the entire album. Listen continuously below or stream track by track on NPR.
One thing is certain: this project is full of life and a rich spirit. Cody weaves together a beautiful story of what's dearest to him and shows us what soul music down to its core. Solid tunes, y'all.
Now 10 years since the release of Headphone Masterpiece, Atlanta singer Cody Chesnutt is preparing to release his sophomore album Landing On A Hundred in October. In efforts to once again self release his album, he is inviting his supporters to help via a Kickstarter campaign.
Ten years wiser, Cody's topic matter on the new album will delve deeper to cover a myriad of real life topics in his now expected style of candor. The title itself holds to this honesty, in fact being derived from the saying "keeping it one hundred." The album was recorded with a ten-piece band at Royal Studios in Memphis, the same place that housed recordings by Al Green, Buddy Guy and Ike & Tina Turner.
Below, stream his newest single "That's Still Mama" and after that peep the video for a live studio session recording of "Everybody's Brother." This all is sounding mighty promising – can't wait for more!
[kml_flashembed movie="http://www.youtube.com/v/qVCXzbMwQrA" width="550" height="445" allowfullscreen="true" fvars="fs=1" /]


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College Hockey:Räty stops 27 as Minnesota tops Ohio State
MINNEAPOLIS — Minnesota scored three times in less than two minutes early in the opener of its series with Ohio State, and that trio of goals proved to be the difference in a 4-1 victory for the home team.
Said Brad Frost, coach of the Gophers (16-3-0, 10-3-0 WCHA), "The quick start paid dividends. We always like to try and start as quickly as we can. We did a really good job of jumping on them early and then just sustaining some pressure."
Minnesota put a shot off the pipe in the game's opening seconds, but was unable to capitalize until a penalty was assessed on the Buckeyes (9-6-2, 6-6-1 WCHA) three minutes later. Rookie defenseman Rachel Ramsey fired a shot in transition that eluded OSU goaltender Lisa Steffes with only two seconds remaining on the power play. Anne Schleper had the assist, her 99th point at Minnesota.
Two more freshmen combined to double the Gophers' lead 26 seconds later, as Rachel Bona buried the rebound of a Meghan Lorence shot. The margin grew to 3-0 in another minute plus, as Emily West crashed the net and the puck bounced in off an Ohio State defender just before the goal was dislodged.
"Last weekend against North Dakota, we saw both situations, where we did and we didn't, and I think that obviously a quick start is one of our keys to success," West said. "Just going out tonight and scoring a quick goal was huge."
The only additional scoring came in the second period, with Amanda Kessel tallying for the Gophers and frosh wing Danielle Gagne answering for the Buckeyes.
"She's been a goal scorer her whole career, right from when she young, and so when she gets her chances, she's pretty good in those areas," Ohio State coach Nate Handrahan said of Gagne.
Her snipe just under the crossbar was the only shot to get by Noora Räty, who made 27 saves in improving to 14-3 on the season.
"She's a world-class goaltender for a reason," Handrahan said. "She made a lot of key stops for them. I think a lot of times with goaltenders, it's the timing of stops as well, and she has got a certain flair for timing as well."
The Gophers juggled their lines, switching seniors Sarah Erickson and West in an attempt to obtain more balanced scoring, and then promoting Bona when an early injury knocked wing Kelly Terry from the game.
"Terry got hit in that first shift and just wasn't able to return, so she's getting evaluated," Frost said. "It is what it is. The good thing is the depth that we have, just able to put some more people in there and get them some more experience and opportunity."
At this point of the season, skating shifts with new linemates can generate some life.
"We tried some new stuff and it seems to be working," West said of skating with Kessel and fellow fifth-year senior Jen Schoullis, each of whom assisted on her goal. "Whoever you're put out with, you have to play. Hopefully, they get along with you as far as on ice and stuff, and so far, it's working."
Steffes finished with 28 saves in OSU's net.
"Their goaltender made some great saves, as did ours," Frost said. "I thought Noora might have had one of her better games of the whole year there tonight. We started getting a little lax on our 'D' zone and our back pressure that's been pretty strong for us the majority of the year. Tonight we had some breakdowns, and Noora was there to answer the bell, but with one game remaining here in the first half, really happy with the three points, and hope to start quickly and maintain that pace all day tomorrow."
His counterpart on the visiting bench also found areas where he hopes to see his team improve.
"I was pleased with how we played for about 50 minutes of the game," Handrahan said. "I think that the first five, we kind of sat back on our heels, and certainly, they're a good hockey team and came out and played hard right out of the gate. And can't take penalties late in the game and expect to come back."
The puck drops at 2:07 Sunday in Ridder Arena for the final game before Christmas break for each team.
"We have to be able to start and play smart road hockey," Handrahan said. "Teams in this league, they come out and they will throw a storm at you early, and you've got to be ready to weather it. We weren't ready to do that tonight, and I'm confident we will tomorrow."
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Please help. I need to find a program/off campus school for my kids so they dont drop out.
Every program I find for my son & nephew has been discontinued. Please, please help me find a school for my boys in or around Federal Way. One has an IEP and is 19 years old, the other just turned 18 and has just been floating around on a 504 he was put on for severe migraine headaches. He was tested at U of W in 4th grade. He was diagnoised with a learning disability and would need extra help. It was the end of year and last year in that school and I was told no time to initiate an IEP. They said 504 would accommodate his needs regarding making up work missed from headaches but never addresses need of extra help. Please,please help . Thank you.In Topics: Choosing a school, Special education
> 60 days ago
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Yeast Flocculation
Brewing yeast flocculation is the most important process for the production of beer that causes the yeast cell to sediment to the bottom of the fermenter at the end of the fermentation. Thus, the brewing yeast can be harvested from the bottom of the fermenter and re-pitching (re-used) for the next batch.
Mechanisms of yeast flocculation
Yeast flocculation is a complicated process that is currently only partly understood. Yeast cells have tendency to adhere each other's and to build up flocks. These flocks can then precipitate on the bottom of fermentation vessel or rise to the surface of beer. This biochemical mechanism requires the presence of at least two types of molecules on the yeast cell surface. One type is cell wall mannans which are produced by the gene products of the MNN genes and are present on the cell surface at all times. Cell wall mannoprotein seems to be important, higher mannan concentrations are connected to stronger flocculation. The other type is flocculins which are the gene products of the FLO (FLO means yeast with a dominant flocculation gene) genes, that are activated only after depletion of nutrients. The FLO bind to MNN on the surface of yeast cells leading to the cross binding of cells and ultimately the formation of flocs, each consisting of several cells.
Following things have been reported to have influence
• Flocculation is stronger in conditions, which are there at the end of fermentation (more
ethanol, less sugars, lower pH etc.)
• Mother cells have that feature; daughter cells create it after a period of time.
• Mitochondria activity seems to correlate with flocculation.
• Oxylipins on cell wall seem to form some binding sites.
• Mg, energy generation and cytoplasmic protein synthesis induces flocculation.
• Ca is important, same with hydrogen bonding (possibly these two together)
Lectin like adhesion
Lectins are plant proteins, which can react with carbohydrates causing precipitations. Lectins are very specific; e.g. concanavalin A makes bonds only with α-1,6-mannose. Probably today the most commonly accepted mechanism is called "Lectin Like Adhesion"
(LLA- mechanism). So, it is a reaction between some proteins in yeast cell to carbohydrates in another cell. Ca2+ changes the shape of this protein and so, in a way, activates it (possibly tiny amounts of Mn are also needed). Some role Ca has also in binding anionic groups of cell wall surface (prot-COO- etc.)
If you have any questions, suggestions, comments, advice, thoughts or you just want to share something with us, please email us on email@example.com. We would love to hear from you.


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Object permanence
Object permanence is "the understanding that objects continue to exist even when we do not see or hear them" (Kalat and Shiota, 2007, p.88).
Baby plays with disappearing ball
Example: http://www.youtube.com/watch?v=rJk5ociUGvY Application: This nine month baby shows how his toy continues to exist even after he does not see it. He keeps putting the ball through the hole in the wooden box and he sees it disappear. Once his mother pulls the box out he sees how it suddenly appear and continues to play with it. The baby eventually understands that if he pulls the wooden box out he can get the ball out and continue playing with it. Just because he does not see the ball once it is in the box it does not mean it does not exist.
Baby finds caterpillar
"'Examples'": http://www.youtube.com/watch?v=wFV9ZYPR3ls "'Application'": Baby Toren is playing with a caterpillar toy and as Ryan takes it from him and hides it, Toren looks for the caterpillar. Toren pulls down the book which in covering the caterpillar and locates his toy. This video illustrates how even children acknowledge that items continue to exist even if the don't see the.
Object Permanence
Example: http://youtu.be/lKZ9IPRKkkU Application: In this video, the infant that is one year old has almost mastered object permanence. Her mother shows her a block and then hides it under a white cloth, and the baby removes the cloth and gets the block. The baby understands that the object (the block) continues to exist even when she cannot see it. She knows that the block is simply under the cloth.
5 month kitten displays object permanence
Example: http://youtu.be/aTfvZjixLiA Application: In this video, the 5 month old kitten is displaying object permanence. As the kitten watches the lady lay a rug out, she then notices the lady show her a little black mouse toy. The lady then puts the mouse under the rug, waiting to see how the kitten will respond. Within seconds, you see the kitten approach the rug, lifting it up with its two paws and mouth, and grabs ahold of the mouse.The kitten knew exactly where the mouse toy was, despite the lady hiding it under the rug, and went to retrieve it by lifting up the rug.
3 year old Tyler
Examples: http://www.youtube.com/watch?v=n8oc0fg8NfI&feature=related
Application: In video Tyler is playing with his stuffed animals. The mother then tells him to look at his stuffed animals. He proceeds to look at them. Then the mother covers them with a blanket and asks him where the animals are at. He lifts up the blanket and uncovers the stuffed animals. By uncovering the stuffed animals he is showing his understanding that objects continue to exist even when we do not see or hear them.


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A dog can make you smile when you are feeling sad and depressed.
Adopt a dog and smile again! A dog is known as man's best friend because they are adorable and smart. Most people enjoy playing and spending time with their dog.
Remember, if you keep your dog happy they will make you smile!
Keep your dog happy by doing the following things: walk them daily, feed them nutritious foods, provide clean drinking water, play with them, keep them clean and well groomed, take them to the veterinarian when they are sick and provide unconditional love. Locate a veterinarian in your area.
Adopt a dog and smile again! If you are a hoarder, do not adopt a dog. A dog must live in a safe environment!
If you have been sad for more than 14 days or depressed contact a doctor or mental health agency.
Enjoy reading Exercise daily: Walk your dog and Happy Healthy News
If you would like to receive an email alert when a new article is written, click on the Subscribe button. The subscription is free.
*Follow YvetteCollins,PharmD on twitter @yvettecollins1
©Yvette Collins, Pharm.D. All Rights Reserved. No part of this article may be reproduced without prior permission from the author. Partial reposting is permitted with a link back to the original article.


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Use science in a sentence
- Euthymia wondered, as well she might, to hear this young woman talking the language of science like an adept. [6]
- Science has multiplied wealth, and facilitated intercourse, and the result is refinement of manners and a diffusion of education and information. [4]
- Our ascent itself was a great achievement, but this contribution to science was an inconceivably greater matter. [5]
- SCIENCE is the topography of ignorance. [6]
- I am obliged to doubt that the three-dollar Science and Health costs Mrs. [5]
- Science was now the object of my devotion. [10]
- Somehow, every time the magic of fol-de-rol tried conclusions with the magic of science, the magic of fol-de-rol got left. [5]
- The controversy between the claims of the practical life and the intellectual is as idle as the so-called conflict between science and religion. [4]
- Since I began teaching in this school, the aspect of many branches of science has undergone a very remarkable transformation. [6]
- Modern, science has taught us this much, at least, that we have by no means fathomed the limits even of a transcendent personality. [9]
- And particularly as regards Science and Health. [5]
- There is a recognized branch of science familiar to all those who know anything of the studies relating to life, under the name of Teratology. [6]
- And if theology pretended to be the science of religion, surely it must submit to the test of the new science! [9]
- The solemn scepticism of science has replaced the sneering doubts of witty philosophers. [6]
- Neither mental bias nor interest gained by any searching examination of the science to which I wished to devote myself, turned the scale. [10]
This page helps answer: how do I use the word science in a sentence? How do you use science in a sentence? Can you give me a sentence for the word science? It may also be related to ged, educator, learn, learning English department of education, private education, school districts, college, and write.
Example sentences with the word science, a sentence example for science, and science in sample sentence.


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Feb. 16, 2002
PULLMAN, Wash. (AP) - Stanford's trip to Washington couldn't have gone any better.
Curtis Borchardt had 19 points, 11 rebounds and five blocks, and No. 12 Stanford used an early second-half run to coast to a 76-63 victory Saturday over Washington State.
Casey Jacobsen added 24 points for the Cardinal (17-6, 10-4 Pac-10), which completed a perfect road swing against the conference's bottom two teams and moved into first place in the Pac-10.
"It's been a while since we swept a Pac-10 road trip," Borchardt said. "Road games are always tough in the Pac-10."
Coupled with Arizona's loss to Southern California, Stanford - which beat Washington on Thursday - moved past the Wildcats into a tie atop the conference.
"We got what we wanted, a win and a sweep and to go home in first place," Stanford coach Mike Montgomery said.
Neither game was easy from the start.
The Cardinal used an 11-2 run Thursday in the first four minutes of the second half to pull away from Washington.
Against the last-place Cougars, Stanford only led 37-34 at halftime but opened the second half with a 17-5 run.
"We didn't come out as flat in the second half, and that's when we took control," Jacobsen said. "The game was a little tougher than we expected, but WSU has some players capable of putting up some numbers."
Marcus Moore did just that, leading all scorers with 29 points. Moore was 4-of-7 from 3-point range with 18 points in the first half for the Cougars (5-18, 1-14), who jumped out to a a 13-3 lead.
But Stanford stayed close, using a 20-16 rebounding advantage, and took its first lead at 24-21 on a 3-pointer by Julius Barnes with 8:17 remaining in the first half.
The Cardinal used the big run to pull away to a 54-39 advantage. Stanford held Washington State to 1-of-6 shooting during the spurt, and parlayed that into its 12th straight victory in the series.
"We had a fairly comfortable margin in the second half once we started to get moving," Montgomery said. "We were in pretty good shape. We weren't in peak mental capacity tonight, but Washington State played hard."
The loss was the 15th in 16 games for the Cougars.
"I thought we played the right style, playing it slow," Washington State coach Paul Graham said. "The second half they came out and accentuated their strengths and pounded it in to Jacobsen and Borchardt."
Jacobsen had 13 points in the second half, and Borchardt added 10.
Washington State closed within 71-61 on Moore's jumper with 2:54 remaining, but Barnes answered with a 3-point shot on Stanford's ensuing possession to end the Cougars' final threat.


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July 1, 20167:57 AM ET
ISTANBUL (AP) — A Chechen extremist masterminded the triple suicide bombing at Istanbul's busiest airport that killed at least 44 people, a U.S. congressman said.
July 1, 20168:04 AM ET
WASHINGTON (AP) — Attorney General Loretta Lynch intends to accept whatever recommendation career prosecutors and federal agents make in the investigation into Hillary Clinton's use of a private email server, a Justice Department official said Friday.
July 1, 20168:10 AM ET
WASHINGTON (AP) — Presumptive Republican presidential nominee Donald Trump has begun formally vetting prospective vice presidential picks.
July 1, 20166:27 AM ET
Your daily look at late-breaking news, upcoming events and the stories that will be talked about today:
July 1, 20168:22 AM ET
LONDON (AP) — Justice Secretary Michael Gove argued Friday that he should be Britain's next leader because he is passionately committed to leaving the European Union — but said he would not trigger EU exit talks this year if he becomes prime minister.
July 1, 20167:56 AM ET
LONDON (AP) — Russian whistleblower Yulia Stepanova was cleared by track and field's world governing body on Friday to compete as a neutral athlete in the European championships and the Rio de Janeiro Olympics.
July 1, 20162:09 AM ET
OMAHA, Neb. (AP) — The rivalry between Michael Phelps and Ryan Lochte goes back more than a decade.
July 1, 20168:02 AM ET
LONDON (AP) — The Latest from Wimbledon (all times local):
July 1, 20167:29 AM ET
LONDON (AP) — With 13 Wimbledon titles between them, Serena Williams and Roger Federer will be back on Centre Court on Day 5 of the championships.
July 1, 20161:38 AM ET
OKLAHOMA CITY (AP) — Kevin Durant started his free agency tour in a familiar place.


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1. DeadliftThis one is a classic, and it's going to work out your back muscles like crazy. The deadlifts work the entire posterior chain, from the glutes, hamstrings and calves -- but most importantly, the lower back.
Start off with a lighter weight until you've mastered the form, then you'll be ready to kick it up a notch and go heavier. This exercise will work your back like it's never been worked before, and you'll feel the results even if it's your first time trying it.


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Scaling Sand Dunes in Magnificent Mozambique
Touching down in Vilanculos, Mozambique "airport" - a grass field with barbed wire at one end, and chickens which scattered as we came into land, I knew instantly I would like this place. I was not disappointed.
Vilanculos is a sleepy coastal town more famous for the Bazaruto Archipelago off its shores. Miles of low lying sand banks which are exposed when the tide goes out create a majestic backdrop. We chose to stay in the town and take a day excursion to the islands which helps avoid the high end resorts and gives you a flavor of the local life.
We spent a day out on the islands, climbing sand dunes combined with two dives, and we had the place seemingly to ourselves. Lunch felt well deserved after leaving our tracks up the towering dune in the midday heat. The view from the top was breathtaking –- turquoise ocean for miles.
The diving was rich in marine life helped by the currents carrying plentiful plankton to the reef. Highlights included a blue spotted puffer fish, two honeycomb morays and both a loggerhead and green turtle. Not to mention the dolphins that accompanied us home.
We booked our diving with Odyssea which I would recommend. Not the sort of dive school where you feel like family but Christina was a very good guide and the outfit was professional.
We stayed at Zombie Cucumber a backpacker hostel which was very homely and Sabrina is a fountain of knowledge about the area, most importantly what to eat where and when. That is when Sabrina isn't cooking herself – her crab curry was to die for. Varanda a few blocks down ocean drive also shouldn't be missed. A spare afternoon? Take a walk to Archipelago Sun and enjoy lunch on the terrace with a few cold ones taking in the view.
Happy Kids at Happy Africa
Being ambushed as our truck pulled into the school yard by a troop of eager, smiling and uninhibited school children was another highlight. We had found through Stuff Your Rucksack and overwhelmed with support from family and friends we had managed to collect 20 kilos of children's books, coloring pens, paint, magazines and toys and were determined to deliver them in person.
We spent a whole morning seeing the pre-school in action. The youngsters lapped up all the attention we could give them - climbing, jumping, clapping, playing football or just holding hands and wearing our sunglasses. A round of "duck, duck, goose" will be long remembered. The pre-school runs from 8-11am five days a week, with as much importance attached to providing nutrition for the children as classroom time. It was a humbling experience and a highlight of the trip. Next time, Stuff Your Rucksack!
Europe has the clock. Africa has the time.
Waving goodbye to Vilanculos we took a "chapas" down the coast, which resembled musical chairs in the back of a combi van. People crammed in, legs and arms flailing, and practically pushed out again at their designated stop.
We took to a dirt road and as we drove through a myriad of towns along the way the locals smiled and waved through the clouds of dust.
The women carry their daily wares piled high on their heads from which we were sold an array of goodies through the windows. 12 hours of travel later, Sweaty and sandy we arrived in Tofo, pulling up right in front of a
man selling fresh coconuts. Not much can beat that coconut juice fresh from the source.
Africa's Galapagos
An ocean marvel was next to leave us humbled. We went scuba diving with manta rays. 6 or 7 of them in total including one 5+ meters across, starring in our very own episode of Oceans. A true Galapagos moment. At one point I was crunched down behind the reef as one of the mantas swam right over the top of us. I had to remember to breathe.
This area of coast line is one of few places in the world you can get so close to these magnificent creatures. The local researchers who conduct much of their ground breaking work in Tofo itself are very generous with their time, giving lectures on Monday, Wednesday and Friday at Casa Barry which shouldn't be missed.
While in Tofo we stayed at Bamboozi Lodge which has a wide range of accommodation and lots of space, at the far end of the beach. The bar serves fantastic food at great value – everything from the prawns to the "peri peri chicken" deserve trying. The attached dive school Liquid Adventures looked after us extremely well and comes highly recommended.
A sloe gin
All too soon our incredible journey through Mozambique came to an end, last stop Maputo. A run down city with mere hints at its earlier glory. Itineraries should include the train station, lunch at the fish market and a sundown Gin & tonic at the Hotel Polana.
Mozambique had wowed and humbled us both on and off its shores. A truly magnificent trip. Don't wait until your friends have already been!
Jennifer Delaney is an economist with a lust for travel. Scuba diving and elephants are among her favorite things. She lives in New York City. Visit her website, Jennifer Travels.
Read more articles about Mozambique on GoNOMAD
About to canter on the beach. Volunteering on Horseback in Mozambique By Anne
Fishermen in Mozambique. photos by Jennifer Delaney. Scaling Sand Dunes in Magnificent
A Shopping at Maputo's Craft Market - photos by Dianne Thomas Mozambique: A Cultural
A fishing dhow returns to shore as the sun rises, Vilanculos. photos by Pip Strickland. Mozambique
Vibrations at Ponta Malongane, Mozambique By Petro KotzA(c) A typical weekend in southern
Baboons inside Gorongosa Park, in Mozambique. photos by Rebeccah Fleming. Gorongosa
- Mozambique - Namibia - Niger - Nigeria - Republic of Congo - Rwanda - Senegal - Sierra Leone - South Africa
Good Vibrations at Ponta Malongane, Mozambique Lome
Wrestling Maputo, Mozambique: A Welcoming City of Contrasts A Family Vacation in Egypt
: Mozambique Mozambique is the perfect place for a beach retreat. 2,000 km of white sand coast along
Oh, he speaks Portuguese!A I thought he was from Mozambique or another African country where
and backpacked across six continents, from Thailand to Mozambique, wringing out every last drop of culture she
museum view. Max Hartshorne photo. As for the food, Cliff ordered Mozambique Chicken which was quite
night) andBeyond operates 29 luxury lodges in 7 African countries: Botswana, Kenya, Mozambique
and Mozambique. When : You can visit Jessica every day from 10am until 12pm and again from 3pm


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06-09 R6 Wheel Installation Tool Instructions
In the kit you will find two pieces: The smaller piece fits in the end of the rear axle.
* The small piece can be installed with the axle in place. Simply hold it in place and strike with a hammer until
it is driven fully into position.
* A bent axle or swingarm or axle adjusters mis-aligned will cause binding when attempting to insert the axle
* Grease the axle lightly before inserting
* Spread the rear brake pads apart with a flat screwdriver
* The next time a rear wheel removal is performed, the other larger piece can be used in this way:
1. With the wheel still off, install the rear brake caliper/carrier in its position.
2. Insert the tool through the swingarm and caliper carrier. This will hold the caliper in place while the wheel
is being installed.
3. Confirm that the rear brake pads are spread out far enough for the brake disc to fit into the caliper
4. Put the wheel into position and install the chain onto the rear sprocket.
5. Insert the axle through the left side of the swingarm and wheel. Push the axle all the way through until the
tool is pushed out of position.
6. Put the washer and rear axle nut on the axle and tighten.
Any questions or problems should be addressed by
contacting us


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The University of Wisconsin-Eau Claire McIntyre Library is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, religion, sexual orientation, age, disability, or other factors irrelevant to participation in the programs at the University. Criminal background checks are required prior to employment.
Student positions
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To be considered for student assistant jobs that may become available, please complete the application form available electronically [PDF] and at the Circulation Desk (1st floor).
You may submit it to the Library's Circulation Desk (1st floor) or you may send it to:
McIntyre Library
Administrative Offices
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Eau Claire, WI 54702-4004
Faculty positions
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Shakespeare and the Documents, Part 1:
Early Life:
Shakespeare's biography has long been a source of controversy. He's one of the greatest writers in the world, yet the first twenty-eight years of his life could be written on the back of a postage stamp. His reticence about himself in his works almost suggests a deliberate act of self-concealment as a person as well as an artist. What is particularly frustrating is that the ten years between his marriage and his emergence as a playwright in London have so far yielded only three documents: the birth of his children, and a court case in which he and his parents tried to recover family property lost when his father's business collapsed. So for more than half of his life - the years which made him - the biographer is forced to see Shakespeare through the eyes of those around him.
It is hardly surprising then, that in the public eye Shakespeare's biography is peculiarly controversial. Theories that he was really Marlowe, Bacon, or the Earl of Oxford, still abound - more documentaries have been made about the authorship controversy than about the man himself. It has to be said that these are all groundless: the primary sources which show that the Stratford Shakespeare wrote the plays are incontrovertible. In fact, in the second half of his life Shakespeare is particularly well documented for his class and profession. But the fact that there is such a controversy at all tells us something important about the problem. Shakespeare's biography is not yet really convincingly anchored in his turbulent times. But a fresh look at the main documents, and the new finds, offers all sorts of interesting clues.
Shakespeare was born in Stratford upon Avon in 1564, only five years or so into the reign of Elizabeth I. The register of baptisms gives 26 April, so he was born maybe three or four days before. In case there be the slightest doubt, the playwright's colleagues in their commemoration volume of his plays after his death, confirm that William Shakespeare of Stratford upon Avon was the author of the plays, and this is backed up by ample testimony from the same time including the poet's will, his funeral monument, and several testimonia from the next couple of decades. His mother was Mary Arden daughter of a well-off farmer in Wilmcote, and distant descendent of the Ardens of Park Hall, who were an important Catholic family in Warwickshire. William's father, John Shakespeare, a former farmer from Snitterfield, was a glover who rose to be alderman and then mayor of the town when William was a boy. John himself is particularly well documented, being named in dozens of documents, and recent finds have included fascinating evidence from government informers on John's illegal money lending and wool dealing.
1564 was an extraordinary time to be born. England was going through nothing less than a Cultural Revolution. In the previous twelve years, the state religion had gone from the hard-line Protestantism of Edward VI to the persecuting Catholicism of Queen Mary, and then back to Protestantism. The first ten years of Shakespeare's life saw an uneasy live-and-let-live before the crisis began to develop in the late 1570s, by which time he had left school. In the aftermath of the Armada (1588) the establishment triumphed, and by the turn of the century the Old Faith was reduced to a minority save in certain areas such as Lancashire.
So Shakespeare's formative years were a time poised between two worlds, between the old and the new. How that translates at a local level we can see in the very rich documents which survive for his town and region. South Warwickshire was a strongly Catholic area, especially in the villages to the north of Stratford in the Forest of Arden, where both his parents were born to old farming families loyal to the Old Faith. Government spies' reports, astonishingly, show a dozen old priests from Queen Mary's day still working as vicars in Arden in 1585, one of whom may well have been the vicar who married William and Anne Hathaway. In Stratford, the town's corporation had many sympathizers with the Old Faith, among them several close friends and neighbors of the Shakespeares. During the time William's father served as constable, alderman and bailiff (mayor) the town officers delayed as long as possible before removing Catholic murals, glass and vestments; some wallpaintings were never destroyed. Perhaps even more significant, of the six schoolmasters employed by the corporation at the grammar school during Shakespeare's boyhood and youth, four were Catholic sympathizers. Simon Hunt, who probably taught Shakespeare, later became a Jesuit.
This fascinating local picture mirrors the national situation. It was a time of "no longer and not yet," half Protestant, half Catholic, and this is the key, I think, to Shakespeare's outlook. In his life in the family, in the town, at school, and at church, he grew up between two worlds. In the privacy of home the Old Faith may have been foremost. His grandfather Robert Arden's will of 1556 is strongly Catholic; his father John appears on a list of Catholic recusants in 1592; and even his daughter Susannah was summonsed for refusing to take Easter Communion as late as 1606 - a crucial document discovered fairly recently in the church court records in Maidstone. The Shakespeare family's story then begins to look like the tale of so many English people in the sixteenth century: caught between old and new, holding on to their affection for old England, while the state swept away a vast and resonant world of symbols of custom and belief, from fairies to prayers for the dead. By the end of Elizabeth's reign most of the country had conformed at least outwardly to the new faith. But by then of course Shakespeare was nearly 40. His life then spanned the great divide.
In this light Shakespeare emerges surely as a much more interesting and ambiguous figure, for whom concealment was not only part of his art but part, perhaps, of a deliberate pattern in his life too. It is intriguing, for example, that during 25 years of lodging in London, with as many as eight addresses indicated in our sources, he is never picked up in the church attendance lists, even in places where it was compulsory such as the Liberty of the Clink in Southwark where he lived in 1599 and maybe later. His one house purchase in London (for which the mortgage documents survive), which was made in 1613, after he had retired to Stratford - had been well known earlier to the government as a Catholic safe house.
"Shakespeare and the Documents: the sources for the bard's life"
Shakespeare and The Documents
The Evidence
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smoffen wrote:actually, does anyone know how to meditate in China? I can't figure it out and I just got this game.
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April 3, 2013
- Northern Illinois is one-third of the way through its 2013 spring football practices and Head Coach Rod Carey says he likes the way the Huskies have approached the five practices to date. "I like the way we're competing. I like the way we're juiced to practice. They are excited to get out here and work."
- With top returning tailbacks Akeem Daniels and Keith Harris Jr. not yet participating in full drills, Giorgio Bowers, Cameron Stingily and Alex Morrow are getting the majority of the reps at tailback for the Huskies. Bowers displayed some tough running Wednesday and also threw several key blocks to spring his quarterbacks.
- A year ago, NIU had just two quarterbacks participating in spring ball in Jordan Lynch and Matt McIntosh. During a couple practices that Lynch sat out, McIntosh, then a freshman in his first spring at NIU, took every rep. This year, the NIU quarterback corps has been doubled as freshmen Matt Williams and Drew Hare have been added to the mix. In 2012, McIntosh was the freshman in his first spring, now he is the "wily" veteran sophomore with game experience under his belt.
- During Wednesday's two-hour practice, a significant portion of the full pads workout was devoted to fundamentals and "mental reps" as the offense and defense ran plays without the ball.
- Once the ball was back in play during "pass skel" (7-on-7), the quarterbacks spread it around to multiple receivers including Da'Ron Brown, Tommylee Lewis and Jacob Brinlee as well as tight ends Desroy Maxwell and Tim Semisch. During "team" competition at the end of practice, it was Brinlee with the 25-yard touchdown catch from Matt McIntosh.
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Brad Pitt and Angelina Jolie toast the sale of their first bottles of wine.
13:06, UK, Thursday 07 March 2013
The first wine to be sold from a French vineyard owned by Brad Pitt and Angelina Jolie is being sold online.
Six thousand bottles of organic Miraval Rose are being sold on the internet for around £90 a case.
The wine, which was praised by one wine critic for its "dynamism" and "expressive fruit", was produced from Grenache, Syrah and Cinsault grapes grown in the scenic Var region of southeastern France on the 40 hectares owned since 2008 by the Hollywood couple.
Pitt and Jolie partnered with the Perrin family of vintners to create and market the 100,000 bottles of Miraval wine that will be sold to independent wine shops and restaurants.
Miraval, bearing the name of the couple's chateau, is expected to follow up on its rose debut with red and white wine.
"With this 2012 rose, Miraval reveals the extraordinary potential of wines from Provence," the Perrin family said.
"This unique terroir naturally expresses itself in the aromatic wine with a round mouth feel that is full of freshness."
The stout bottle, more akin to a Champagne bottle, has a discrete circular black, white and gold label.
The only mention of the US actors couple is on the back, saying "Bottled by Jolie-Pitt and Perrin".
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New Version of Sun Ray Software Available Now
By jacki decoster on Oct 15, 2008
Sun has just released the new version of Sun Ray Software. You can download it here.
The latest release of Sun Ray Software provides a more seamless PC-like experience through full screen Windows desktop display and improved multimedia performance.
The key new feature in Sun Ray Software 4 10/08 is the enhanced multimedia playback capabilities for Windows (MPEG-4 (H.264) and Windows Media Video 9 (VC-1)), Solaris and Linux.
Other product updates include - Expansion of built-in VPN choices, enhanced security and authentication capabilities, support for 30-inch monitors and in-session desktop resizing (which is great if you're working in multiple locations that have different size monitors). More details on the Think Thin blog.
As IT budgets become increasingly stretched due to the tough economic climate, lowering energy consumption and reducing administration costs are becoming more important than ever. Virtual desktop computing is growing increasingly popular because it helps to conserves company resources and requires less system administration - while offering a secure, cost effective and flexible solution.
Sun Ray Software is a key component of Sun's Virtual Desktop strategy and Sun Virtual Desktop Infrastructure (VDI) Software. Early access for the next version of Sun VDI Software will be coming soon.
More information on Sun Ray Software 4 10/08 can be found here - including full product features and details on the perpetual license and the new Sun Ray Software subscription offering.
Also visit Chris Kawalek's blog for his perspective on this announcement and for the latest news from Sun's Thin Client & Server Team visit their blog.


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Oct 3, 2012 9:30 AM
If mealtime is already a circus in your house, you might as well add the Big Top Tablecloth ($68) to the ring, err, table. If it's not, make it one! Throw a themed party with bear claws, popcorn, peanuts, and cotton candy-flavored cupcakes. And then invite us to it.
If you've got a product or service that you'd like to promote on Outblush, click here to find out about our advertising opportunities.
Outblush is a blog for girls who love to shop. Our staff digs up the best clothes, home stuff, beauty items, and more. New items are posted every day — bookmark us and check out:


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The Green Bay Packers have a chip their shoulder, but the San Francisco 49ers wants to knock it off.
Saturday night the two teams will clash to decide who will move on to the NFC championship game. For the 49ers, it is still new territory being a return visitor to the divisional round,
However, for the 2010 world champions, it's terrain they know already, and also what will be needed to win.
"It's going to be a physical battle." "You know that's what it's going to be. It's going to be a physical game. We don't know how it's going to unfold -- but it's going to unfold physically. We know that," according to Tramon Williams as told to the Milwaukee Journal Sentinel.
"When people talk about the Packers, the first thing people say is, 'They have a high-powered offense' and things like that," Williams said. "But we're a physical team."
Left guard T.J. Lang said: "They've got some big, strong guys up there in their front seven." "But when we're playing our good football, we play just as physical as anybody else does.
That's the attitude that we have and when you go against a group that plays physical, hard-knock football, the biggest thing is to make sure you're matching their effort, their intensity the whole game.
"If we try to do that, if we match their effort as best we can, I think we have a good chance."


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Lucas Leiva notched up his 200th appearance for Liverpool against West Brom on Monday night – and in tribute, LFC TV Online have put together a special clip of the Brazilian's best moments for the club so far.
The midfielder has established himself as a fan favourite since arriving from Gremio in the summer of 2007.
Lucas has been forced to endure some tough times during his Reds career so far, but the 26-year-old has never shirked the challenge of becoming an integral part of the team.
LFC TV Online subscribers can see exactly why our No.21 is so revered on the Kop in our exclusive clip below.
Click here to sign up for LFC TV Online>>
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Pornhub saw some interesting traffic over the weekend as the Super Bowl took place, with traffic dipping heavily at 3PM, but building up incredibly high from Denver between 7-9PM.
With the game starting at 3PM, traffic on Pornhub dipped heavily, but as of around 5PM it looks like porn watchers from Denver decided to skip the game in favor of some digital lovin'. Seattle-based Pornhub visitors weren't alone, but they didn't start jumping onto the site until around 9PM, hours after Denver fans checked out of the Super Bowl.
Some interesting numbers for Pornhub here, to see how quickly fans at home were jumping back onto their desktops and laptops and onto Pornhub during a disappointing game for the Broncos.


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Throughout the 80s and 90s the martial art film was all the rage in the straight to video market. For a while it all but disappeared, but over the last few years they have been making a comeback. The latest Dragonwolf looks to keep that trend alive, but does it bring the action or will it miss the mark all together?
Dragonwolf follows two young men who possess the intellect and ferocity to flourish, carve a name for themselves as the most efficient and unstoppable hit men feared by even the most evil criminals, but when a woman of rare beauty mysteriously enters the brother's lives she blinds them with her sweet promises and turns them against each other, resulting in an epic battle that threatens to bring the Devil's Cauldron to the brink of destruction. From the moment this film began it was a problem. The story is all over the place and has no real cohesion to make it make any sense. The entire movie is in English yet still has one of the worst voiceover tracks in a long time. It was likely due to the lower budget and bad initial micing, but the audio was just laughable. To make matters worse the acting itself was just horrible with only a few managing to deliver a somewhat decent performance, but as a whole pretty bad. Normally you can get past all of that with a martial arts film with the inclusion of some great fight action and while there is plenty of it here most of it just isn't all that good. Make no mistake, there are a few great fight sequences here and there, but for the most part they are just not very well choreographed.
This had the makings of a decent martial arts flick, but it gets lost in itself due to its many issues and just doesn't manage to work on really any level. As mentioned there are a few decent fights that fans of the genre might find enjoyable, but it's unlikely anyone will make it that far through it. Like any genre, action films affect everyone differently so decide for yourself when Dragonwolf hits Blu-ray and DVD on July 29th.


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MINNEAPOLIS -- UCLA earned its second straight road win and its ninth-consecutive road victory over an unranked opponent with a 58-55 come-from-behind win at Minnesota at Williams Arena on Friday afternoon in the first game of the Subway Classic.
Minnesota took a 55-47 lead at the 5:27 mark on a pair of free throws by Rachel Banham. But that would be the last points the Golden Gophers would score as the Bruins engineered an 11-0 run to steal a victory. Thea Lemberger drained a three-pointer (5:03) to make it 55-50. Then Atonye Nyingifa sank a pair of free throws to trim the lead to 55-52 with 4:07 to go. Luiana Livulo grabbed an offensive rebound off a Lemberger miss and scored to pull UCLA to within 55-54 (1:44). After another defensive stop, Lemberger scored on a pull-up jumper in the lane to give the Bruins a 56-55 lead. Lemberger and Madeline Brooks both went 1-for-2 from the charity stripe in the final minute while the Bruins got three more defensive stops in that stretch to seal the victory.
Nirra Fields tied her career-high in three-pointers with four for the second straight game and finished with 19 points to lead UCLA. Lemberger added 17 points in the win. Nyingifa, who was playing with flu-like symptoms, saw her 14-game double-figure scoring streak come to an end on 2-for-13 shooting. She finished with nine points, eight rebounds, three steals, two assists and one block.
With the victory, UCLA improves to 5-5 on the year while Minnesota drops to 9-3. The win by the Bruins snapped Minnesota's modest six-game home winning streak.
The Bruins led 29-28 at the break. For the game, there were six ties and 13 lead changes. The Bruins outrebounded the bigger Minnesota squad, 47-38. The Golden Gophers entered the game leading the nation as a team in three-point shooting (45.1%). The Bruins held Minnesota to 35.7% (5-for-14) from long range.
UCLA was outshot from the field, 36.8% to 31.7%. But the Bruins hauled in a season-best 21 offensive rebounds to hold a 20-4 edge in second-chance points.
Banham led all scorers with 24 points. Amanda Zahui B. was the only other Golden Gopher to score in double figures, completing a double-double with 16 points and 10 rebounds.
Redshirt junior Corinne Costa played in her first game in over a year and had four points, six rebounds, one assist and one block, but fouled out in 21 minutes of action (at 5:36 of the second half).
Freshman guard Savanna Trapp (Esko, Minn.), who is redshirting the season, had a lot of friends, family and former coaches in attendance, which was announced at 5,065 for the game.
The Bruins return to action for their final game of the Subway Classic tomorrow against Auburn (8-3). Tip-off is slated for 2:00 p.m. (PT) at Williams Arena.
UCLA at Minnesota


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ALABAMA HILL: Views are tops atop this hilltopThis neighborhood is perched at the top of Alabama Hill and is home to Alabama Street, the steep arterial most people take to get to Lake Whatcom from the city center. Most residents in the Alabama neighborhood have views of the Lake Whatcom or the city, depending on which side of the hill they live. On the north side of the neighborhood, sidewalk-lined streets wind around the crest of the hill and the well-kept yards in front of large homes. The south side of the neighborhood has a less-planned feel, with older houses and no sidewalks but similarly spectacular views.
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Pride of Ownership line the large one and two-story homes. Located on top of a hill, the edgemoor neighborhood boasts views of Bellingham Bay and Chuckanut Bay along the long western border. The population consists mostly of retirees, empty nesters, and families and homes on large lots and open spaces. See featured listings in Edgemoor.
Smaller homes are positioned closely together on smaller lots and large apartment complexes surround Western Washington University's campus. Many of the larger houses have been converted into duplexes and one portion rented out to college students.
There are families living here as well and their childrengo to the three public schools in the neighborhood: Larrabee and Happy Valley Elementary Schools, and Sehome High School.
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The Fairhaven business district is close by, and Sehome Village and the Viking Plaza provide many shopping amenities.
MOUNT BAKER: Sweeping views and rapid growthThe Mount Baker neighborhood is one of the fastest growing residential areas of Bellingham, offering sweeping views of the city and Bellingham Bay from atop Barkley Boulevard on the north side of town. The Barkley Village area is designated as a "priority urban village" in the City's comprehensive plan. This area will continue to develop with a mix of residential, commercial and light industrial land uses providing jobs and services. Search for Barkley neighborhood homes here. Key open space features include the Squalicum and Baker Creek corridors, Sunset Pond, and the 50-acre Northridge Park. The "Bay to Baker" trail system will traverse the neighborhood roughly along the Squalicum Creek corridor.
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