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New Biomarker for Heart Disease?
by Dr. Nithin Jayan on June 17, 2011 at 2:58 PM Health In Focus - G J E 4
Recent findings suggest new links between lung disease and disease of the heart. An increased blood level of a protein produced by a diseased lung was found to be associated with increased mortality in heart patients.
People with bad lungs or who smoke get heart disease, but the exact molecular mechanism behind this was never clear.
AdvertisementA biomarker or biological marker is a substance that can be used as an indicator of a particular biological disease. For example Trop-T is one biomarker whose elevated level points to a heart attack.
The biomarker being discussed is called surfactant protein-D (SP-D). It is produced by chronically inflamed lungs. SP-D that leaks from damaged lungs has anti-inflammatory and antioxidant properties. Whether SP-D itself is an accelerator of atherosclerosis, i.e. whether it can speed up the collection of fatty materials along the walls of arteries is not known. It is however now clear that lung inflammation plays a role in the pathogenesis of heart and blood-vessel disease. Results of the study were published in the European Heart Journal.
A more detailed study is mandatory since findings would have colossal significance. The SP-D protein as a biomarker to risk-stratify cardiovascular-disease patients would gain the upper hand over traditional markers like blood cholesterol and C-reactive protein.
Future studies that can clarify if SP-D is notorious in accelerating atherosclerosis are also called for since this would mean development of new drugs or molecules that block this protein from getting into the blood. It would help people cope better with atherosclerosis.
Source: European Heart Journal
Source: Medindia
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Elkhart community in shock after two women killed by shooter at Martin's Super Market
The Elkhart community is in shock and two families are mourning the tragic loss of two women killed by a man at a local grocery store.
ELKHART — The Elkhart community is in shock and families are mourning after two women were tragically killed by a man armed with a semi-automatic handgun and a large knife at a Martin's Super Market grocery store in Elkhart Wednesday night, Jan. 15.
Police say Shawn Walter Bair, 22, of Elkhart, entered the grocery store around 9:30 p.m., walked around for about a half an hour. Just after 10 p.m., police say he shot Krystle Dikes, 20, and Rachelle Godfread, 44, before being shot and killed by police. Sgt. Trent Smith with the Indiana State Police said when the Elkhart officers responded, they heard gunfire as they entered the store and followed the sound to where they found the man pointing his gun at a man forced to his knees.
Dikes was working at the store at the time of the shooting. She had recently moved back to Elkhart after living in Muncie for a year. Her mother, Juanita Whitacre, said that she was looking for an apartment and had tons of friends.
Godfread was shopping when she was shot. She had also recently moved back to Elkhart to be closer to her son, an IU South Bend student and basketball player. She was looking forward to refreshing her life and re-planting her Elkhart roots.
Related Stories
The store is located at 3900 E. Bristol St.
The Elkhart Truth is following this story and its impact on the community closely. The links below cover the full range of stories The Elkhart Truth has covered in relation to the shooting at Martin's. Make sure to check back at this page for future coverage.
The shooting
The victims
The gunman
Police response
The Elkhart community reacts
Moving forward after the tragedy

subset: commoncrawl


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You get 100 piece confetti packaged ready to use. The confetti is hand punched and is used to compliment any theme to your party or shower. The mustaches and bows are 1" in size. For such a great price, you can buy multiples or many colors. Use them for holidays as table décor or at any special function. Convo me if you do not see what you are looking for. I can do many other colors and themes.
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2 KCK men arrested in dogfighting caseUPDATED 8:56 AM CDT Mar 26, 2013
Federal prosecutors announced charges against two Kansas City, Kan., men accused of training dogs to fight and using the animals in dogfighting events.
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This photo journal tells the story of the wonderful days spent in and around London during the author's two visits in 2007. Follow his photographical journey as you explore Central London, take a trip to Notting Hill, commune with nature at Greenwich and admire the many wonderful architecture in and around London. (94 pages)
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I'm an autodidact amateur photographer. After many years of compact camera usage I got my first Digital SLR in late 2007 and been shooting photographs ever since. The opportunity to venture out with nothing more but what the world has to offer and my camera interests me the most in taking photographs. I am mainly into landscape and architecture photography. Photography Equipment: Body: Canon 5DMII Lenses: Canon EF 24-70mm f/2.8L USM Canon EF 70-200mm f/2.8L USM
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TIME IT TAKES 30 minutes
HOW OFTEN Do these moves 3 to 5 times a week. For best results, warm up — cycle, jog, or march in place — for 5 to 10 minutes first.
SEE RESULTS IN 3 to 4 weeks, especially if you combine this workout with cardio and a healthy diet. At the end of this nine-week program, you'll look more sculpted, feel tighter — and you may even lose 3 to 5 pounds.
EQUIPMENT A pair of hand weights (we used 8-pound ones) and a fitness ball (about $15; performbetter.com).
TO KICK IT UP A NOTCH At the end of 9 weeks, try increasing the weight and adding on another weekly session.
(works quads, hamstrings, thighs, buttocks)
A. (not shown) Start with your feet about 2 feet apart, making sure your body is in neutral-spine position, feet pointing out. Hold weights on each side, just above hipbones.
B. Bend your knees to lower into a squat. (Be sure they don't extend over your toes.) Lower as deeply as you can without sticking out your butt. Return to start, squeezing buttocks and abs. For all 9 weeks, do 2 to 3 sets of 20 to 25 reps.
(works hamstrings, buttocks)
A. (not shown) Lie on floor and place your heels on the seat of a sturdy chair or bench. (If you're a beginner, place your feet flat on floor about hip-width apart.) Extend arms on floor to either side.
B. Squeeze your buttocks to push your hips up, so your body forms a straight line from knees to shoulders. Hold for 30 to 60 seconds. Lower to start; repeat. For all weeks, do 2 to 3 sets of 25 reps.
(works entire core)
A. (not shown) While standing, bend forward to place your forearms on a fitness ball, hands in loose fists. Position arms in an A shape, fists touching each other and elbows apart. Step your legs behind you, one at a time. (If you're a beginner, brace the ball against a wall.) Center your weight over elbows.
B. Keeping your back flat and your neck relaxed, tilt your pelvis, and contract your abs to hold a plank position for 20 to 60 seconds. Lower and repeat for 3 to 5 reps for all weeks.
(works back, buttocks)
A. (not shown) Lie facedown with a fitness ball under your hips, hands behind your head, legs extended with toes on the floor. (If you need more stability, brace your feet against a wall.)
B. Keeping your head, neck, shoulders and back aligned, contract abs and buttocks, and lift your chest off the ball, squeezing shoulder blades together. Return to start; repeat. For weeks 1 to 3, do 3 sets of 15 reps. For weeks 4 to 6, do 3 sets of 12 reps. For weeks 7 to 9, do 4 sets of 8 to 12 reps.
(works thighs, buttocks, core)
A. Stand in lunge position, with your left leg forward and knee bent, your right leg back and poised on right toes. Keep your torso upright and your weight centered over the balls of your feet. Hold weights in both hands, arms extended down. Bend knees to lower torso down into a lunge position.
B. Contract left buttock to rise, simultaneously lifting right foot off the floor and bending knee to contract hamstring. Return to start; switch legs, and repeat. For all weeks, do 3 sets of 10 lunges on each leg.
(works abs, lower back)
A. (not shown) Lie on a fitness ball, positioning it under your mid and lower back. Place your feet hip-width apart and flat on the floor. (For extra stability or if you're a beginner, brace toes against a wall.) Extend both arms overhead, palms together.
B. Contract your abs by pulling the bottom of your rib cage down toward your hips to lift your torso off the ball, flattening your navel into the ball as you come up. Return to start; repeat. For weeks 1 to 3, do 3 sets of 12 to 16 reps. For weeks 4 to 6, do 5 sets of 15 to 20 reps. For weeks 7 to 9, start in the same position, but twist to one side and then the other. Do 2 sets of 12 reps.
(works triceps, shoulders, core)
A. (not shown) Sit on the edge of a chair or bench. Bend your legs so your knees form a 90-degree angle. Extend left leg on top of a fitness ball. (If you're a beginner, do not use the ball; instead, place both feet on the floor.) With straight arms, grip the edges of the chair and slide your butt off the front.
B. Flatten your navel to your spine, and bend your elbows to lower toward the floor. When your elbows form 90-degree angles, straighten up to start; repeat. For weeks 1 to 3, do 3 sets of 15 reps. For weeks 4 to 6, do 3 sets of 12 reps. For weeks 7 to 9, do 4 sets of 8 to 12 reps.
(works chest, shoulders)
A. Lie with your upper back and head on a fitness ball holding weights, feet hip-width apart. Squeeze buttocks to keep back flat. Bend arms so elbows form right angles; align elbows with underarms.
B. (not shown) Press weights up and together into an A shape. Lower to start; repeat. For weeks 1 to 3, do 3 sets of 15 reps. For weeks 4 to 6, do 3 sets of 12 reps. For weeks 7 to 9, do 4 sets of 8 to 12 reps.
(works shoulders, back, triceps)
A. (not shown) Sit on a fitness ball with your feet flat on floor, holding weights. Bend forward from the waist, keeping your back straight.
B. Keeping arms bent slightly, raise weights up to about shoulder level. Return to start; repeat. For weeks 1 to 3, do 3 sets of 15 reps. For weeks 4 to 6, do 3 sets of 12 reps. For weeks 7 to 9, do 4 sets of 8 to 12 reps.
Originally published in MORE magazine, May 2006.
NEXT: 10 Minute Workouts: Core Routine
First Published Mon, 2009-04-06 18:53
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The TPCC is an interagency committee chaired by the Secretary of Commerce. It was established under the Export Enhancement Act of 1992 to provide a unifying framework to coordinate the export promotion and export financing activities of the U.S. government and to develop a government-wide strategic plan for carrying out such programs. The Advocacy Center leverages the capabilities and resources of these agencies to support your request.
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text: International Journalism Program Launched in 1998, Hamline's certificate in international journalism (CIJ) is the first undergraduate program of its kind in the United States. It seeks to cultivate and develop global understanding, advanced communications technology, and social networking. Through the process, students also develop an understanding of world politics and cultures, second language abilities, and analytical and technological skills. The program aims to create a new breed of journalists who understand other countries and cultures and who can communicate that understanding through the news media. Political science, global studies, foreign language, and communications majors are often drawn to the program, but it complements nearly any degree that emphasizes multicultural understanding. Students receive hands-on journalistic experiences through domestic and overseas internships and a capstone independent media project. They work with local media partners in Minneapolis/Saint Paul and participate in overseas exchange programs with universities throughout the globe. Local partners include KFAI Radio, Saint Paul News Network, the Minnesota Women's Press, the Asian American Press, La Prensa, and the Daily Planet. Overseas exchanges include those with Universität Trier in Germany, Universidad Catolica de Valparaiso in Chile, Université Gaston Berger in Senegal, and United International College in China. Students can also choose from a variety of approved internship sites in countries throughout the world. The CIJ program is extremely competitive. Students must have at least a 3.0 grade point average for their application to be considered. The program is composed of six required courses in addition to the international internship. Students must have knowledge of a foreign language or take two semesters of a foreign language prior to their time abroad. The department encourages students to write for the Oracle (Hamline's student newspaper) or other approved university publications for at least one semester. Other opportunities include Fulcrum, the student literary magazine; Liner, Broke Starving Writers Club, a creative writing group; and the Communications Club. Students who earn Hamline's certificate in international journalism are prepared for a wide variety of careers. These include: reporter, writer, editor, newscaster, news analyst, program director, public relations specialist, business executive, lawyer, peace Corps, Foreign Service, and politician. Read more about life after Hamline.


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Here's a deal from Groupon for a getaway to the Bahamas from South Florida. The trip is on the MSC Divina May 17 from Miami. The discount prices are for two nights on the ship.
The Groupon discount prices are $129 to $599 a person, for a room with at least two guests. The regular prices are $159 to $699.
The deal is good through Tuesday, May 13. For information click this link, discounts for Bahamas cruise.
The post Discounts for Bahamas cruise from South Florida appeared first on Florida on the Cheap.


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Stephen Anthony Ingram
Position: T
Height: 6-4 Weight: 324 lbs.
Born: May 8, 1971 in Cheverly, MD
High School: DuVal
College: Maryland (school history)
Drafted by the Tampa Bay Buccaneers in the 7th round (215th overall) of the 1995 NFL Draft.
Weighted Career AV (100-95-...): 0 (15060th overall since 1950)
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Paganelli, Massimiliano*; Stephenne, Xavier*; Gilis, Allison*; Jacquemin, Emmanuel§; Caude, Alexandra Henrion||; Girard, Muriel||; Gonzales, Emmanuel§; Revencu, Nicole‡; Reding, Raymond†; Wanty, Catherine*; Smets, Françoise*; Sokal, Etienne M.*
*Pediatric Gastroenterology and Liver Unit
†Pediatric Surgery and Transplant Unit
‡Human Genetics Centre, Cliniques Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
§Pediatric Hepatology, Bicêtre Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
||Genetics Department, Necker Enfants Malades Hospital, Paris, France.
Address correspondence and reprint requests to Professor Etienne M. Sokal, MD, PhD, Department of Paediatrics, Université Catholique de Louvain, 10, Av Hippocrate—1200 Brussels, Belgium (e-mail: email@example.com).
Received 6 December, 2010
Accepted 13 February, 2011
The authors report no conflicts of interest.
Tight junctions between hepatocytes and cholangiocytes play a fundamental role in separating bile flow from plasma. Secondary alterations of tight junctions are well described in many cholestatic disorders inducing an increase in paracellular permeability and subsequent liver damage (1). The core proteins of tight junctions are composed of strands of claudins and occludin. Claudin-1 is a member of the claudin family expressed in liver and skin and mapping on chromosome 3q27-q28. The CLDN1 gene homozygous mutation was shown to cause a rare autosomal recessive syndrome associating neonatal ichthyosis to sclerosing cholangitis (NISCH syndrome) and first described in 2 unrelated Moroccan families (2,3). Only 8 patients, from 4 different families, have been described as affected by this syndrome so far (2–5). They presented with ichthyosis and neonatal cholestatic jaundice. Cholestasis varied from a transient remitting form to more severe fibrogenic conditions (2–5). Two patients required liver transplantation (3,5). One of them showed regression of skin lesions and alopecia after the transplant (3). We describe here 4 new patients from an inbred family of Moroccan origins, all presenting with the clinical features of NISCH syndrome and a mutation of the CLDN1 gene.
In all patients, other causes of neonatal cholestasis were excluded (6,7). Table 1 summarizes characteristics of patients described here and of previously reported patients (2–5).
Patient 1, a girl, was born from consanguineous healthy parents (Fig. 1A V:1). At birth she showed generalized lamellar desquamation and mild jaundice. Acholic stools, dark urine, itching, and hepatomegaly were noted in the first weeks of life. At 1 month of age, serum total bilirubin was 9.1 mg/dL, conjugated bilirubin 8.3 mg/dL, alanine aminotransferase (ALT) 142 U/L (normal range <63 U/L), and gamma-glutamyl transferase (GGT) 75 U/L (normal value for age <230 U/L). The abdominal ultrasound showed no particularity, but the gallbladder was not visible. A hepatobiliary scintigraphy with 99mTc-IDA showed a markedly delayed bile flow. A liver biopsy revealed a panlobular cholestasis, without bile duct proliferation, and no evidence of acute hepatitis nor bile duct paucity. Despite lack of evidence of biliary atresia, the patient underwent a portocholecystostomy at the age of 6 weeks. No cholangiography was performed. There was no significant change in jaundice or itching following the surgery. The patient was then referred for further evaluation and liver transplantation. At the age of 4 months, the patient had marked jaundice, hepatomegaly, refractory itching, dry skin, moderate ichthyosis, and rickets. Her height was at −1.3 standard deviations. She had no clinical or ultrasonographic signs of portal hypertension, and liver ultrasonography showed a heterogeneous pattern. Direct bilirubin was 5.6 mg/dL, ALT 446 U/L, GGT 849 U/L, and serum bile acids 264 μmol/L (normal range <8 μmol/L). In view of the persistent cholestasis, the child underwent split liver transplantation from cadaveric donor at age 1 year. Liver histology performed on the explanted organ showed extensive portal fibrosis with interlobular septa and moderate inflammatory infiltrate with important bile ductular proliferation, bile plugs, and absence of interlobular bile ducts. The posttransplant course was uneventful, with normalization of hepatic function and disappearance of cholestasis. Itching and skin lesions improved moderately but did not disappear, although serum bile acid levels had normalized. Enamel dysplasia and hypodontia were noted. The diagnosis of NISCH syndrome was established after the patient's younger sister was referred with the same clinical picture. Genetic testing revealed a homozygous deletion in exon 1 (c.200-201delTT) in the CLDN1 gene as previously described (3). Five years after transplantation, serum liver function tests and liver ultrasonography are normal. Itching remained significant and was related to ichthyosis.
A second sister was born prematurely for an unknown reason, and died a few days after delivery from unspecified causes (Fig. 1A V:2). No investigations were performed to evaluate possible liver disease in this child.
The second affected sister (Fig. 1A V:3) was admitted to the hospital at the age of 2 weeks for bleeding from the umbilicus, 4 days after the umbilical stub fell. At physical examination, the patient showed scleral icterus, extremely dry skin with lamellar desquamation, and parietal and occipital alopecia. Blood tests showed a markedly elevated international normalized ratio (INR [>7.0]) and cholestasis (total serum bilirubin 6.4 mg/dL, conjugated bilirubin 2.8 mg/dL), with normal serum ALT and GGT. After vitamin K intravenous injection, INR normalized and bleeding resolved. Liver ultrasonography was unremarkable. A hepatobiliary scintigraphy with 99mTc-IDA revealed a mild reduction of radionuclide liver uptake and absence of its excretion. A liver biopsy was performed and showed normal interlobular bile ducts, normal portal spaces, and regular lobular architecture with intracellular and canalicular cholestasis. Skin biopsy showed orthokeratosis, hyperkeratosis, and granular layer hyperplasia. Microscopic examination of the hair revealed trichoptilosis and focal area of trichorrhexis nodosa. No intracytoplasmic vacuoles were seen in blood cell smears. Genetic testing revealed the same homozygous CLDN1 gene mutation as in her elder sister, confirming the diagnosis of NISCH syndrome. The patient was treated with 20 mg/kg/day of ursodeoxycholic acid (UDCA) and ADEK vitamin supplementation. Biochemical cholestasis and physical signs resolved and at 4-year follow-up she complained only of mild pruritus and dry skin, which were treated by moisturizing topical therapy.
The third affected sister (Fig. 1A V:4) showed ichthyosis without jaundice at birth. Since the third day of life, she received UDCA (20 mg/kg/day). At 3 months of age she presented with cholestatic jaundice (serum ALT 495 U/L, serum conjugated bilirubin 5.4 mg/dL, and normal serum GGT). Liver ultrasonography was unremarkable. Moderate itching appeared along with parietal and occipital alopecia. Genetic analysis confirmed the presence of the known homozygous CLDN1 gene deletion. At 9 months of age, serum bilirubin and ALT normalized, whereas GGT rose to 474 U/L. Mild biochemical signs of cytolysis and cholestasis persisted at 3-year follow-up under UDCA therapy (serum ALT 74 U/L and GGT 139 U/L, normal serum bilirubin) in the absence of hepatomegaly and signs of portal hypertension. Alopecia and ichthyosis were still present and the child complained of moderate itching.
As with her elder sisters, the fourth affected baby (Fig. 1A V:5) had dry skin and mild lamellar desquamation at birth. At 5 days of age, the physical examination was unremarkable, but biochemical analysis showed a mild cholestasis (conjugated serum bilirubin 3.1 mg/dL, normal serum ALT and GGT). Treatment with UDCA (10 mg/kg/day) and liposoluble vitamin supplementation was started. At 1 month of age, she had hypocholic stools, and the dose of UDCA was increased to 30 mg/kg/day, with subsequent normalization of stools and serum bilirubin. Liver ultrasound showed a marked parenchymal heterogeneity with surface nodularity in the absence of portal hypertension. The same homozygous CLDN1 gene mutation as her elder sisters was found. At 6-month follow-up, alopecia and ichthyosis were evident (Fig. 1C-D), and biochemical signs of biliary involvement were still present (serum ALT 60 U/L, GGT 299 U/L, normal total serum bilirubin). No liver biopsy has been performed. The parents did not allow her to undergo magnetic resonance cholangiopancreatography.
The parents had a double consanguineous relationship and they were both phenotypically normal. The mother was shown to be heterozygous for the described mutation in the CLDN1 gene, whereas the father refused genetic analysis (Fig. 1A, IV:1 and IV:2).
NISCH syndrome is a rare disorder characterized by alopecia, ichthyosis, and progressive cholestasis from birth. It was first described in 2002 by Baala et al (2) who analysed 4 patients belonging to 2 different Moroccan families from the Rif region. NISCH was assigned initially to chromosome 3q27-q28. A homozygous 2-bp deletion in exon 1 of the CLDN1 gene (c.200-201delTT), leading to a frameshift and a subsequent stop codon, was identified as the cause of the syndrome (3). A second homozygous frameshift mutation in exon 2 of the CLDN1 gene was reported in a Swiss child with NISCH syndrome characteristics (4).
We report here a new family of 4 daughters affected by NISCH syndrome, originating from the same Moroccan region as 3 of the published families. The mutation identified also was the same as the one previously described in these families (3,5). Therefore, a founder effect can be supposed. The children were born full term after uneventful pregnancy and presented with mild ichthyosis from birth, which was initially misinterpreted as simple dry skin. They had neonatal jaundice, of various severities, and developed clinical and biochemical cholestasis within the first few weeks of life. Even though initially not always high, GGT levels were invariably elevated within the first months of life and they were a marker of biliary disease during follow-up. Overall, despite the same homozygous mutation in the CLDN1 gene was found, the liver disease appeared with variable severity among the affected members of the same family, ranging from regression of cholestasis to extremely early liver fibrosis requiring liver transplantation (Table 1) (2–5).
All previously published patients presented with ichthyosis and hypotrichosis. One baby was born with a collodion membrane. Alopecia was usually frontal, parietal, or occipital, with sparse eyelashes and eyebrows. Neonatal jaundice, pruritus, pale stools, and biochemical cholestasis were present in all of the described patients but 1, along with hepatomegaly and portal hypertension in some cases. Cholangiographic features of intrahepatic biliary tree anomalies were found in all 5 patients who underwent imaging studies. At liver biopsy the typical "onion-skin" appearance of periductal fibrosis was never seen, as expected considering the age of the patients (8,9). Additional features included enamel dysplasia, oligodontia, hypodontia, and vacuoled eosinophils. Like the 4 girls described here, these 8 patients showed different degrees of liver disease, ranging from absence of liver involvement or transient neonatal cholestasis to persistent cholestasis with cirrhosis (Table 1) (2–5). The reason for such phenotypic variability is not known.
In NISCH syndrome it is believed that the primary defect of claudin-1 in hepatocytes and cholangiocytes leads to loss of cell polarity and to paracellular leakage of bile constituents (ie, bile acids) that may induce cholestasis by decreasing bile flow and fibrosis, respectively. It is likely that UDCA, a choleretic and cytoprotective bile acid, led to some improvement of cholestasis in treated cases as reported in some patients with isolated neonatal sclerosing cholangitis (10). The use of UDCA was supported by its well-known effects on biochemical values and histological progression of primary sclerosing cholangitis (11). Even though GGT remained high in 3 of the 4 patients described, serum bilirubin normalized under UDCA by the ninth month of life in all of the children except for 1 (patient 1), who started therapy when the disease was far too progressed. Nevertheless, it is difficult to state whether improvement was secondary to UDCA administration or to the natural progression (or regression) of the disease.
Patient 1, who had been mismanaged undergoing corrective biliary surgery, which probably worsened the disease course, received liver transplantation at the age of 1 year. Despite normalization of cholestasis and normal serum bile acids levels, liver transplantation did not lead to significant improvement of ichthyosis, contrary to previous observation (2,3). This may be expected, because claudin-1 is also a key component of tight junctions between keratinocytes. Furuse et al (12) showed that claudin-1 knockout mice presented a severe impairment of epidermal barrier function and died within 24 hours after birth because of dehydration. Ichthyosis found in all of the described patients is secondary to this defect of epidermal barrier. Therefore, it cannot be corrected by liver transplantation, which is only indicated in case of end-stage liver disease and not for the extrahepatic, tissue-bound, manifestations of the syndrome (13,14).
Nagtzaam et al (5) suggested that bile duct paucity could be a primary phenomenon in NISCH syndrome because their patient bile ducts were not replaced by scar tissue. Ductopenia is a well-described feature of histopathological pattern found in sclerosing cholangitis, and it is typically found in stage 3 (according to Ludwig classification) (15,16). In children, it has been described in up to 60% of patients (8,9,17). The absence of interlobular bile duct in patient 1 was found on histopathological examination of the explanted organ after liver transplantation and was accompanied by bridging fibrosis (Fig. 1B). These findings were consistent with a stage 3 sclerosing cholangitis and were not present at the liver biopsy performed at presentation. Fibrosis and minimal bile duct proliferation were associated with ductopenia in 1 of the patients described by Hadj-Rabia et al (patient A3, Table 1) (3). Even though the possibility of a direct role of tight junction disease in bile duct paucity is fascinating and deserves further investigation, portal inflammatory infiltrate, ductular proliferation, portal fibrosis, and periportal inflammation, found by Nagtzaam et al, are compatible with sclerosing cholangitis, and it is difficult to affirm that ductopenia was a primary phenomenon.
One more patient with thickened skin, cholestasis, alopecia, and hypothyroxinemia was recently described by Shah and Bhatnagar (18) and suspected of having NISCH syndrome. The magnetic resonance cholangiopancreatography was unremarkable and he had no signs of sclerosing cholangitis at liver biopsy. No clear signs of ichthyosis were evident and no skin biopsy has been performed. The alopecia was localized and appeared after the resolution of a neonatal ulcer. Because this patient did not undergo genetic testing for CLDN1 mutations and the clinical picture was not typical, no definite diagnosis of NISCH syndrome can be posed, and this case was not included in Table 1.
Claudin-1 has been found to be necessary to hepatitis C virus (HCV) entry in permissive cells. Evans et al (19) have shown that even a moderate downregulation of CLDN1 expression inhibited HCV infection, thus explaining HCV tissue tropism by means of low-level expression of CLDN1 in extrahepatic tissues. Recently, monoclonal anti-claudin-1 antibodies proved to inhibit HCV infection in primary human hepatocytes (20). Claudin-1 is therefore being considered an interesting candidate target for anti-HCV therapy because its blockage could be complementary to HCV protease and polymerase inhibition. NISCH syndrome is the only known human condition involving a deficit of claudin-1. The existent murine model does not live long enough to allow liver disease to develop. For such a reason, NISCH syndrome phenotypic and pathophysiological characterization is of major interest to understand and preview possible adverse effects of a future anti-HCV treatment consisting of claudin-1 inhibition.
These reported cases confirm the existence of NISCH syndrome and its intra- and interfamilial phenotypic variability. Liver disease severity proved to be unpredictable. Early UDCA therapy may be of benefit and may slow disease progression. Liver transplantation does not lead to the resolution of extrahepatic manifestations and should be reserved for progressive liver disease. Finally, even though it is an extremely rare condition, a better definition of NISCH syndrome features could be of general interest as a model of claudin-1 deficiency.
This article has been cited 3 time(s).
Copyright 2011 by ESPGHAN and NASPGHAN
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Colorado received its first snowfall of the season on September 23, 2013. Some places like Loveland Ski Area received 6 inches. This means that the annual snowmaking arms race is about to begin.
Typically, Loveland Ski Area and Arapahoe Basin, both in Colorado, try to duke it out in friendly competition to be the first ski area to open for the 2013-2014 season in North America. This way they can claim marketing bragging rights the entire year! One year Wolf Creek in Southwestern Colorado beat them to the finish line due to a tremendous amount of natural snow. Last year, a mid-western snow storm enabled Minnesota's Wild Mountain to open October 6th, 2012.
How do ski areas make snow? Making snow is both a science and an art at ski areas these days. There is a tremendous amount of technology behind it. Compressed air and water are shot through a gun or a fan and when the mixture hits the ambient air temperature, it crystallizes and falls to the ground as artificial flakes. Low humidity and low temperatures are necessary for making snow. Typically, resorts will make snow when the temperature is 28 degrees Fahrenheit or lower.
Who will win the snowmaking arms race this year and claim the title of first resort open in North America? Stay tuned as temperatures drop and conditions are ripe for making snow.


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Maria von Trapp, the last living sibling of the famous von Trapp family singers has died at 99 of natural causes. Her half-brother, Johannes, issued a statement to CNN News.
Maria was the third child of Capt. Georg von Trapp and Agathe Whitehead and she had six siblings, Rupert, Agathe, Werner, Hedwig, Johanna, and Martina. Maria's parents, Georg and Agathe, were talented musicians, and all the children learned to sing and play instruments. After Agathe's death from scarlet fever, Georg von Trapp married Maria Kutschera five years later. Together, Maria and Georg had three more children; Eleonore, Rosemarie, and Johannes. Maria wrote a book about their life, The Story of the Trapp Family Singers.
It was Maria's book that prompted "The Sound of Music" (1959 Broadway show and 1965 film) and two German movies as well. The 1965 movie starred Julie Andrews as Captain von Trapp's second wife and Christopher Plummer as Baron von Trapp. The movie was a huge hit, winning best picture and four other awards.
After the Trapps escaped from Nazi-occupied Austria in 1938, they moved to the United States, traveled the world, and purchased a family home in Stowe in 1950. The elder Maria von Trapp died in 1987.
In a statement after his half-sister's death, Johannes wrote, "Thank you for your thoughts. Maria had a wonderful lie and while we will miss her, the memories of her will live on."


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Posts tagged "ohio"
Adoption Reform, Right-to-Life Style
Kathryn Joyce reveals what's really going on with the adoption reform bill currently being debated in Ohio.
Sponsored by PETA
Last week, lightning struck the infamous "Touchdown Jesus" outside an Ohio church. (They had no lightning protection, I guess.) This week People for the Ethical Treatment of Animals (PETA) offered to rebuild all 62 feet of the now-crispy "King of Kings" statue in exchange for (of course the publicity) and the right to...
Aryan Jihad and the Elephant in America's Living Room
A holy war is a holy war is a holy war? By Meera Subramanian Here's a riddle for you: How can a small neo-Nazi march, organized to draw attention to the alleged persecution of white people by black people, and a counter-demonstration of approximately 600 blacks, take place in Ohio and not spur a single...


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The University of Arizona athletics department issued the following release at Lute Olson's weekly news conference today (Monday, March 6):
Senior forward Hassan Adams will not accompany the University of Arizona men's basketball team to Los Angeles for its participation in the Pac-10 Tournament, head coach Lute Olson said Monday.
Adams, 21, will not play in any game of UA's appearance in the tournament, due to a violation of a team rules, Olson said.
He will rejoin the team for a potential NCAA Men's Basketball Championships appearance, Olson said. Arizona plays Stanford in the Pac-10 Tournament on Thursday. NCAA competition begins the following week, should UA qualify.
Statement from Hassan Adams:
"I apologize to the team, to the coaches, the university and the fans for my violation of a team rule. I accept the coach's decision to be suspended from the Pac-10 Tournament. I wish the team well and hope for its success. I'm looking forward to participating in the NCAA Tournament if Arizona is invited."


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Epicentre's Comments
(1) comment by Epicentre
Status Update (1)
Currently at 413 pets, more about leveling 30 pets to 25 for the better trap.
Just looked myself up in rankings on my relm Shadowsong EU, it appears I'm no.22 total with no.17 alliance.
And I firmly believe that Scourged Whelplings are a myth. Camped for quite some time, but still nothing :(.
Posted: January 03, 2013 11:21:30 AM
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Want Help Picking Stylish Outfits for Traveling?
The Five Lesbians You Can't Avoid
Never Again Will I Belong To Any One But Myself
One Trip To The Dollar Store Can Organize Your Whole Life
What Cuddling Says About You
Kristen Stewart Opens Up About Her Fluid Sexuality
Never Throw Out Your Leftovers Again
How to Save Money on Heat at Night
Straight Talk: Posture Tips for Working Women
3 Ways to Land a Guy Who Wants to Get Married
5 Ways Our Authentic Self Builds Healthy Relationships
5 Tips for Taking Your Social Presence Offline
15 Self-Affirmations to Keep You Focused and Motivated
Brilliant Money-Saving Travel Hacks
Using This Men's Tool Could Save You Hundreds
Yoga For Beginners: 5 Gentle Yoga Poses for Every Body
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Addicted to Men? Take the Quiz
500+ Men Share What Bothers Them Most About Women
3 Tips for Surviving a Job Loss
Ireland Baldwin Enters Rehab Post-Angel Haze Split
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Never Skip This Home Winterizing Task
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Trust Your Man? 9 Signs That He Is Cheating On You
How to Stop Procrastinating and Why We Do It


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Water Grows the Texas Economy
Across the Panhandle and South Plains of Texas, the vast Ogallala Aquifer underlies 36,000 square miles of Texas. The water used for agricultural production brings billions of dollars into the economy every year, creating jobs and income for people in Lubbock, Amarillo and throughout the region.
It is vital that we find ways to conserve this valuable resource without damaging the economy. It can be done. We can conserve water for the future without sacrificing jobs and economic growth today. Watch this video to learn how
Conservation in Action
See how Texas farmers work to conserve water and share advances with one another
RFD-TV's Out on the Land recently covered Texas Alliance for Water Conservation field day near Muncy, Texas. The participants learned about and saw various water saving technologies used by a Texas corn farmer and award-winning water conservationist. Watch the episode HERE.
Latest News
Ogallala Aquifer Initiative Widely Used by Farmers to Improve Water Application
By Quenna Terry
No one has a greater stake in conserving water than those who depend on it for their livelihood, and Texas farmers and ranchers on the Panhandle and South Plains regions are no exception.
Four years ago, in response to declining water levels of the Ogallala Aquifer, the Natural Resources Conservation Service (NRCS) in Texas launched the Ogallala Aquifer Initiative (OAI) program in an effort to assist producers in addressing water quantity and quality concerns. The initiative has helped landowners improve irrigation systems and enhance the economic viability of cropland located above the aquifer. It also can offer opportunities to convert to non-irrigated production.
"The Ogallala Aquifer Initiative provides farmers and ranchers with technical assistance and financial assistance to support water and energy savings through proven conservation programs," said Mark Hall, NRCS Farm Bill program specialist in Lubbock. "More producers in Texas are applying advanced irrigation water management technologies to monitor crop demand and prevent overwatering."
Currently, over 151,000 acres are enrolled in the initiative for more than $23 million. Read more
Study finds High Plains crop production supports 103,000 jobs
An economic analysis conducted by Texas Tech University and Texas A&M AgriLife Extension found crop production supported more than 103,000 jobs and generated more than $12.2 billion in economic activity in 2010 in the Texas High Plains region.
Those findings come from a new, first of its kind economic model that can now be used to measure the economic effects of different policy options such as changes in water regulations, energy costs, and federal farm programs according to one of the leaders of the research, Darren Hudson, Ph.D, the Larry Combest Endowed Chair for Agricultural Competitiveness at Texas Tech.
"We've always known crop production was a huge part of the economy of this region, but now we have a comprehensive model that can measure in dollars and jobs the total amount of economic activity generated by growing, selling and processing crops in the Texas High Plains," Hudson said.
The measures in the study reflect the impact of a wide variety of economic activity including production costs, such as buying seed, fertilizer, fuel, labor and equipment, as well as post-production processing of crops in the area, including livestock and dairy usage, cotton gins, grain elevators and other relevant processing. Read more
What are ag producers doing?
Texas agricultural producers are making a number of strides to conserve our natural resources such as conservation tillage, irrigation conservation tools, and more.
In 2011, we followed a Panhandle corn producer's corn field on drip irrigation, learn more about his success with this conservation method here.
Ogallala Aquifer Initiative Widely Used by Farmers to Improve Water Application
What is Drip Irrigation?
Drought conditions continue in areas of Texas following last year's worst drought on record across the state. Efficient water is paramount in the agricultural industry, as Texas farmers work to grow the crops consumers and livestock rely on. With water being a finite resource, this topic is not one that will be dropping by the wayside any time soon. That is why Texas Corn Producers has teamed with the USDA-Natural Resources Conservation Service in Texas to provide an informational resource for producers on drip irrigation, which it released on the Water Grows Jobs YouTube Channel this month. Learn more about these videos here


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June 26, 2014 | Volume 44, Number 25
After just learning that the Haines Animal Rescue Kennel hired an out-of-town person to fill what was advertised as a part-time animal control officer, I am appalled at this community's refusal to employ its own residents. (I offered to voluntee...
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Tuesday, November 9th ETF Movers: (LD, AXFN, AXID, JFT, UBC, SIL)
November 9th, 2010
In trading on Tuesday, the iPath DJ-UBS Lead TR Sub-Idx ETN (NYSE:LD) is outperforming other ETFs, up about 4.71% on the day. Also up on the day are the iShares MSCI ACWI ex US Financials Index (NYSE:AXFN) up 4.24%, and the iShares MSCI ACWI ex US Industr (NYSE:AXID) up 3.71%.
And underperforming other ETFs today is the KEYnotes First Trust Enh 130/30 LgCp ETN (NYSE:JFT), down about 7.03% in Tuesday afternoon trading. Also down on the day are the UBS E-TRACS CMCI Livestock TR ETN (NYSE:UBC) down 6.62%, and the Global X Silver Miners ETF (NYSE:SIL) down 5.83%.
Have you ever wondered how billionaires continue to get RICHER, while the rest of the world is struggling?
"I study billionaires for a living. To be more specific, I study how these investors generate such huge and consistent profits in the stock markets -- year-in and year-out."
CLICK HERE to get your Free E-Book, "The Little Black Book Of Billionaires Secrets"


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For the more information about natural sounds and night skies in the National Park Service, please visit http://www.nature.nps.gov/sound_night/.
Rate Your Night Sky
The darker the sky, the more stars can be seen. The following simulated images depict how the constellation Orion appears under various sky conditions. Images are courtesy of GLOBE at Night. How good is your sky at home?
Last Updated: April 23, 2012


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Golden Boy Hybrid
Golden Boy is an Indeterminate 80 day tomato. It produces 8 oz Beefsteak type tomatoes. This Hybrid (two heirloom plants open aired cross pollinated) variety is a heavy producer of medium size golden yellow fruit with great taste. It's a large plant. You can stake or cage this variety. If staking space 18" apart. If caging or leaving to sprawl, space 24" apart.


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Royals Close a Successful Winter Season
Winter brought several shining moments for the Eastern Mennonite University athletic teams in the 2005-06 season. Men's Basketball Men ...More
1,000 Points Times Four
By Mike Barber, Daily News-Record In a rarity, a quartet of EMU basketball players ...More
A Bruising Presence
Amanda Renalds by Michael Rothstein, Daily News-Record Eastern Mennonite University star Amanda Renalds says she "bruises really easily." The proof is on her arms and legs, where 10 black-and-blue blotches ar ...More
Tough Draw For EMU
They have been underdogs before ...More
Lady Royals Relax In NCAA Round 1
They huddled in a conference room in the Eastern Mennonite University athletic offices Sunday. Snacking on pizza, the newly crowned Old Dominion Athletic Conference women ...More
Lady Royals Reach ODAC Semi-Finals
The Eastern Mennonite University women ...More


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Larry Christopher Jermaine Tripplett
Position: DT
Height: 6-2 Weight: 300 lbs.
Born: January 18, 1979 in Los Angeles, CA
High School: Westchester
College: Washington (school history)
Drafted by the Indianapolis Colts in the 2nd round (42nd overall) of the 2002 NFL Draft.
Weighted Career AV (100-95-...): 26 (3866th overall since 1950)
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More about Metal MilitiaCountry of origin: Fort Lauderdale, FL, USAFounded: 1999Status: ActiveOfficial homepage: Metal Militia
More Band Histories Current Updates Print article Rating explanation
METAL MILITIA a Ft. Lauderdale, FL based Heavy Metal band formed in 1999 have been called the "Next Generation of Metal" by magazines from around the world including Rock Hard (Germany), The Metal Observer (Germany) Metal Integral (France), Heavy Metal Forces (Japan) and US based Metal Edge and Pit magazines. Known for their special blend of European Thrash mixed with American Hardcore sound, METAL MILITIA was catapulted onto the national music scene in 2003 with their Debut CD "Perpetual State Of Aggression" earning the band two Grammy® Considerations in the Best Metal Performance and Best Rock Album categories.
Performances on nationally known festivals including Locobazooka! (www.locobazooka.com) where METAL MILITIA was selected to perform as a "future star" with 15,000 people in attendance playing along side National Recording artists STAIND, SEVEN DUST, ILL NINO, LACUNA COIL, SMILE EMPTY SOUL just to name a few. The band known for its hard work ethic has spent the past two years touring the South East through the Midwest with stops at Milwaukee Metal Fest, March Metal Meltdown V finding themselves as a supporting act for great bands LIKE GOD FORBID, SWORN ENEMY, SPINESHANK, 40 BELOW SUMMER and showcasing their music at the 2003 Atlantis Music Conference in Atlanta, GA. Rounding out the band is Jason Mooney (2002 Drum finalist) for SLAYER, Chris Manning whose speed and amazing skill as lead guitarist elevates the band to a new level of playing followed by George Buritica on rhythm whose back up vocals adds a new dimension to the band sound.
As spring 2004 approaches, the band is gearing up for a busy tour schedule with shows on Sun N Steel Metal Festival, Tampa, FL in March, NJ March Metal Meltdown and Sick As Sin Metal Fest in Lowell, MA. In April the band returns to Florida to begin pre-production on their sophomore album with a special 4 songs EP sampler schedule for release this summer. METAL MILITIA has proven that persistence, focus, drive and endless promotion pays off with an ever growing fan base expanding around the country and throughout Europe and Southeast Asia. National and foreign media and internet radio are tracking this evolving group predicting they are the next generation of Metal and Hardcore music to break through the barriers and bring their intense stage show and music to the masses.
Current Line-Up:Paolo Gregoletto – Vocals & Bass Jason Mooney – DrumsGeorge Buritica – Rhythm Guitar & Back Up VocalsChris Manning – Lead GuitarPrevious members:Chris Reiser – Lead Guitar (on "Perpetual State of Aggression")Nick Phares – Drums (on "Perpetual State of Aggression")Mike Alber – Rhythm Guitar (on "Perpetual State of Aggression")
Paolo Gregoletto – Vocals & BassChris Reiser – Lead GuitarMike Alber – Rhythm GuitarNick Phares - Drums "The Metal Observer" Review "The Metal Observer" Review


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Something bold is emerging from the woods, on the outskirts of The City…..
Silver Dollar City is announcing its Biggest Investment in the Past Decade – a 10 million dollar highly themed attraction!
Travel beyond the safe haven of the 1880s Silver Dollar City to a place where adventure awaits!
This daring new attraction features several "World's Only" elements!
After a year of planning and months of construction… we will finally – SOON, this morning, share all of the details!
From now through opening day follow the progress of this exciting new adventure at www.silverdollarcity2013.com.
What do we know? It's taking…
59,000 wood screws
89,000 bolts
4.4 million pounds of concrete
5.6 miles of welding
800,000 pounds of steel
And half a million board feet of lumber to construct this massive structure!
This construction site covers mountains, valleys, trees, woods, train tracks – spanning over 6 acres of land!
Tough. Audacious. Headstrong. This new attraction is born from legend and full of mystery!
This new attraction was designed to utilize and preserve the natural landscape, with two or more trees planted for every one removed during construction.
Nothing is off limits in the Silver Dollar City frontier but there is one certainty –
The Good Guys Always Win.
The Adventure Begins in 2013 at Silver Dollar City!
For information visit http://www.silverdollarcity2013.com.


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Why is ivy leaf so beneficial for your immune system*?
Ivy leaf is a traditional ingredient used for centuries to support bronchial health.*
Why use Bronchial Soothe®?
It supports lung and bronchial passageway health.*
It's for your entire family.*
Unlike alcohol-based syrups, the ingredients in Bronchial Soothe® provide support for the whole family. This non-drowsy formula is well-tolerated in children, too!
Take as follows, two to six times per day, as needed.
Adults: 2 tsp (10 mL).
Children 6 years of age and older: 1-1/2 tsp (7.5 mL).
Children 2 to 5 years of age: 1 tsp (5 mL).
If pregnant, nursing, or taking any medications, consult a healthcare professional before use.
† Based on 2000 calorie diet.
purified water, vegetable glycerol, fructose, natural orange flavor with other natural flavors, sucrose laurate, potassium sorbate (to protect flavor), citric acid, licorice flavoring, peppermint oil
†† For homeopathic products: these indications are based solely on traditional homeopathic use. They have not been evaluated by the Food & Drug Administration.
* For dietary supplements: this statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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Legislative Teacher Resources
Find Legislative educational ideas and activities
Showing 141 - 160 of 965 resources
Our System of Checks and Balances
Pupils study the governmental system of checks and balances between the individual branches. The balances are reviewed and the goal of the lesson is to develop and answer the question, "What are some ways the three branches of our...
8th - 12th Social Studies & History
War Making: Executive and Legislative Powers
Young scholars examine executive and legislative powers. For this federal powers lesson, students determine who has the power to wage war in the U.S. government. Young scholars analyze the Constitution and research historical precedents...
5th - 12th Social Studies & History
The President's Cabinet: Choosing the Right Person for the Job
Students examine the Federal Confirmation Process for filling cabinet members by completing a confirmation process flow chart. They research the process, and participate in a mock Confirmation Process.
8th - 11th Social Studies & History
Marsh v. Chambers & the Establishment Clause
1983 Supreme Court case Marsh v. Chambers, which centers on the question of whether or not opening a legislative session with a prayer violates the Establishment Clause in the First Amendment to the US Constitution, is the focus of a...
9th - 12th Social Studies & History CCSS: Adaptable
War Powers Act and the Constitution
The strength of this plan, which focuses on the War Powers Act, is in the included supplementary materials. Class members read several provided documents, take notes, and discuss their opinions and then deliberate within small groups or...
9th - 12th English Language Arts CCSS: Designed
Congressional Committees and the Legislative Process
Students consider the importance and influence of congressional committees. They research congressional committee assignments, jurisdictions and responsibilities as illustrations of the basic principles of American federalism.
9th - 12th Social Studies & History
US Government: The Checks and Balances System of the US Constitution
Students examine the responsibilities of the 3 branches of U.S. government. In this checks and balances lesson, students identify the powers of the legislative, executive, and judicial branches of government. Students share examples of...
6th - 8th Social Studies & History
The Importance of Representative Democracy
Students examine the general concept of representative democracy, and compare/contrast the American representative democracy to the monarchical system. They research the role of legislative bodies in serving the government, particularly...
9th - 12th Social Studies & History


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Beyond3D has posted a preview of ATI's upcoming Radeon 9100 IGP with Dual Channel DDR-400, AGP 8x and Hyper Threading support but only 533MHz FSB support for the Pentium 4 line.
Much of the configurations of RS300 follows that of Intel's own Springdale chipset, with a Dual DDR 333/400MHz memory bus. At present ATI do not have an 800MHz FSB chipset license, meaning that although 400MHz DDR RAM can be used the CPU FSB will still be limited to 533MHz. Sources indicate that the chipset is fully capable of supporting and 800MHz FSB but its just a question of timing with the license - in other words, watch this space.More information @ Beyond3D


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Maggie Sottero
Visit Village Bridal Boutique in Babylon Village, NY to choose your bridal gown (address below).
Your gown should reflect your personality, taste and style. Every part of your wedding works in harmony, and your wedding gown is no exception. Whether planning an elaborate church wedding or a simple intimate affair stay in harmony with the rest of the elements of your wedding. Here are the different styles of wedding dresses:
The A-line dress features a shape that is fitted around the bodice and flows out to the ground, resembling the outline of an uppercase A. The dress flows from the bust to the hem with an unbroken line. There are some classic, traditional styles that never loose there appeal, the A-Line dress is one of these styles. This style would be appropriate for any style wedding.
The versatile shape can accommodate many different elements. Modifications to necklines, waistlines, or fabrics can accentuate your best features and hide those you don't care too much about.
You can choose a more elaborate design with a fuller skirt for a formal wedding and a simple elegant design for a garden wedding. The A-line is also the most flattering for most body types. For the full-figured woman, the A-line style lengthens the whole body without drawing attention to your waistline. Choosing a V-necks or scoop necks flatter look best on full-figured women. If you are a pear shape (bottom heavy) an A-line would also be very flattering and helpful in bringing balance.
For its elongating effects it would also be appropriated for petite brides. However, the petite bride should avoid fuller skirts which will make you look 'bottom heavy'. You want to keep your wedding dress proportionate to your body.
Added embellishments can also affect the look of the A-line dress. Lace overlays or bead work can make a simple A-line dress appear more formal, while a ribbon or bow can make a stylish statement.
The empire style gown is a high waistline (right under the bust) from which the rest of the dress flows down to the hem. This style also suits various degrees of formality.
Various options in necklines and sleeve styles can change the style of the dress to reflect the style of your wedding. The skirt style is also an important style element on the empire cut. Depending on the silhouette you want, you can allow it to flow freely or contour to your body.
The flow of lighter fabrics like chiffon or organza on the empire design. It brings movement and flow from the waistline. I love the romantic movement that lighter fabrics bring. These lighter fabrics are usually layered over a base fabric like satin.
The empire dress fits most body types. Brides with a smaller bust will benefit from this style since it draws attention to the neckline and creates definition. Inversely, because of its traditionally square neckline it can conceal a large bust by minimizing the size of your breasts. Brides with a long torsos, short legs or pear-shapes can benefit from this style.
The column or sheath dress has a narrow shape that flows straight down from the neckline to the hem. This style to hug the body and show any and all of your curves. The column/sheath style lends itself to all types of weddings, especially causal occasions on the beach, or intimate evening events at home or at a banquet hall.
The sheath/column style is fairly simple. You can change the appearance with different elements, various necklines, sleeves, and lengths. For a beach or garden wedding you might opt for a strapless sheath dress.
Usually the column barely grazes the floor. However, for an intimate afternoon garden or home wedding you can try a knee length skirt. For a more traditional church wedding add a bustle and train. The length of your dress can add character and formality to your gown.
Different fabrics can change the statement the column dress makes. Soft flowing fabrics can be appropriate for a slip dress. Heavier fabrics like brocade or damask, which maintain their shape are appropriate for more formal gowns.
This style is best worn by lean figures, both short and tall. This is not a very forgiving style and does little to hide problem areas, like bottom heavy shapes. Petite brides will benefit from the elongating effects of this style
Comfort can also play apart in your dress selection, this style might minimize your ability to move, sitting and dancing comfortably might be an issue. Pleats or gathering on the back will alleviate these issues.
Ball Gowns
The ball gown style is perfect for brides dreaming of a Cinderella moment in time for their wedding. This style pairs a fitted bodice with a full skirt that can either be one piece or separates. This is most appropriate for traditional weddings where you want to maintain a certain level of formality.
You can select various necklines and sleeves for this dress. Once again creating various combinations will result in various looks.
As mentioned before fabrics make a difference in the overall effects, you could have satin or a chiffon overlay for a romantic and traditional look. A bodice with elaborate beading or lace work paired with a simple satin skirt will draw attention to the upper body. Light layers on the skirt will help to create a floating effect. The ball gown may require a petticoat or crinoline to support its structure. Layering fabric, such as organza, taffeta, or tulle, can also create this same effect.
This style can suit most body types, however the ball gown is ideal for slender or pear-shaped figures since the full skirt helps to accentuate the waist and hide the lower body. This may not work well for petite brides, the fullness of the skirt can overwhelm the bride who may not have the height needed to balance the size of the skirt. If your heart is set on the ball gown look, you can try an A-line dress with a slightly fuller skirt and you can get the desired look.
This style is fitted through the bodice, hips, and thighs, swelling out into a skirt-shaped "bell" around the knees.
You can have a variety of necklines and sleeve lengths with this style. You can go strapless or carry long sleeves, it is all up to you. The design of this dress stands on its own, so the variations are endless.
The skirt part of this dress is its primary influence. The skirt can flare out above the knee, at the knee, or below the knee for slightly different silhouettes. You can also modify the shape and hem of the skirt to change the look of the dress.
Fabric plays a part on how formal this dress will look. Light-weight silks and satin are perfect for a slip style dress. Heavier fabrics will be great for more formal styles. The mermaid style fits can be worn casual beach wedding, or a formal evening affair.
The mermaid cut is not for everyone. It is one of the designs that takes a lot of confidence to pull off. This design is best for slender figures, both short and tall. This is definitely an unforgiving style as it accentuates every curve. This style does not work well for brides with full figures. However, confidence is the key to this dress and if you feel that your curves are all in the right place and you want to flaunt them, it is your day, wear it with confidence. If you lack confidence your perfect figure will not carry this dress and evoke the elegant, sexy look this style calls for.
Choose your undergarments well when selecting this style, embarrassing underwear lines are the last thing that you want on your big day. Not to mention it might take away from the elegance of your overall look.
Visit Village Bridal Boutique in Babylon Village, NY to meet with a bridal expert that will help you choose your dream dress. They have the right bridal gown waiting for you Village Bridal Boutique, 10 john Street, Babylon Village, NY 11702 631-587-2800


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Celebrate The Man, The Music, The Movement: Fela! on Broadway
"There has never been anything on Broadway like this production!"
– The New York Times
Giant Step is giving away tickets to FELA! on Broadway, the highly acclaimed Afrobeat musical directed and choreographed by Tony® Award winner Bill T. Jones. Enter to win a pair of tickets below. Two lucky winners will be notified via email.*
The online contest is now closed. Get discount tickets to FELA! here
*Email address must be verified. By entering, you will be added to the Giant Step mailing list. Show dates for tickets in March/April TBA.
NO PURCHASE OR PAYMENT OF ANY KIND IS NECESSARY TO ENTER OR WIN A GIANT STEP CONTEST. EACH CONTEST IS LIMITED TO ONE ENTRY PER PERSON. By entering into a contest ("Contest") posted on the Giant Step Web site (the "Site"), you agree that you have fully understood and agree to be bound by these Contest Rules (the "Rules") and any other limitation that may be applicable to that contest. Please refer to the content page of the Site located above for additional information on any particular Contest.
1. PROMOTION PERIOD Each Contest promotion period shall begin at time that Contest is posted and shall end on the end date ("End Date") specified on the Contest Page.
2. ELIGIBILITY Entrant must be 13 years of age or older and a legal resident of the United States residing in the fifty (50) states or District of Columbia to be eligible to win a prize(s). Contests are void in Puerto Rico and where otherwise prohibited or restricted by law. Employees of Giant Step, co-sponsors of a Contest and, their respective parents, subsidiaries, divisions, affiliates, distributors, suppliers, advertising, promotional or any other persons or entities directly associated with a Contest (collectively, "Giant Step and Promotion Parties") and members of their respective immediate families and/or persons living in the same household as such persons, are not eligible to enter any Contest that they are associated with.
3. HOW TO ENTER: Anytime during the Contest Period, go to [http://www.giantstep.net/contest/], choose the contest you wish to enter and click on the link. Then answer the question posed and click on the "CONTINUE" button. If you are a Giant Step member provide your password and email address and click on the "SUBMIT" button. If you are not as yet a Giant Step member complete the information requested on the Membership Form and then transmit the Membership Form by clicking on the "SUBMIT" button. Information requested on the Membership Form consists of your birth date, name, address (including zip code), phone number, valid email address, screen name and password. Alternatively, you can mail the answer on a 3″x 5″ card/paper, including the name of the Contest, your name, email address, address to: Giant Step Contest 62 White St., Suite 3R New York, NY 1001. Please mark the envelope or card clearly with the name of the Contest that you wish to enter.
4. PRIZES: The prize(s) for each Contest will be listed next to the Contest's description on the Contest Page together with their estimated retail value. No substitution, transfer, or cash equivalent of prizes is permitted; provided, however that Giant Step, at its sole discretion, may substitute a prize of equal or greater value.
5. DRAWING AND NOTIFICATION: Winner(s) of Contests will be selected at random within 14 days of the End Date for that Contest from all eligible entries received by the judge(s) (the "Judges"). The Judges' decisions are final and binding in all respects. Odds of winning depend on the number of eligible entries received. Winners will be notified by mail, email and/or phone. If a potential winner is found to be ineligible, fails to respond to notification within ten (10) days, or is otherwise not in compliance with these Rules, an alternate winner will be randomly selected. For a list of winners, send a self-addressed, stamped envelope, to: Giant Step 62 White St., Suite 3R New York, NY 1001 stating the particular Contest you are interested in or consult the list of winners to be posted at [http://www.giantstep.net/winners/] 21 days of the End Date for that Contest.
6. GENERAL CONDITIONS: Winners are responsible for all applicable federal, state, and local taxes, if any, on the prize. All entrants agree to be bound by the Rules and decisions of the Judges. All entries become the property of Giant Step and will not be acknowledged or returned. Except where prohibited by law ,entry into a Contest or acceptance of prize constitutes consent, without further compensation, to use your name and likeness for editorial, advertising and publicity purposes worldwide and in perpetuity, in any and all forms of media, now known and hereafter devised. Winners may be required to execute an affidavit of eligibility, a liability release, and a publicity release ("Affidavit and Release") which must be returned to and received by Giant Step within ten (10) days from winner's receipt thereof. Failure to comply may result in disqualification and an alternate winner may be chosen. If, for reasons beyond Giant Step's control, the Contest is not capable of completion as originally planned, Giant Step at its sole discretion, reserves the right to suspend, cancel or modify the Contests, without liability. ALL ISSUES AND QUESTIONS CONCERNING ANY CONTEST OR THE CONSTRUCTION, VALIDITY, INTERPRETATION AND ENFORCEABILITY OF THESE RULES SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH ENTRANT HEREBY SUBMITS TO THE JURISDICTION OF THOSE COURTS.
7. CONDUCT OF PARTICIPATION: Giant Step, at its sole discretion, reserves the right to disqualify any person suspected of tampering with any Contest or the operation of the Site. Non-compliance with these Rules will result in entrant's disqualification. ANY ATTEMPT BY AN ENTRANT OR ANY OTHER THIRD PARTY TO DELIBERATELY DAMAGE THE SITE OR UNDERMINE THE LEGITIMATE OPERATION OF ANY CONTEST IS A VIOLATION OF LAW AND SHOULD SUCH ANY SUCH ATTEMPT BE MADE, GIANT STEP RESERVES THE RIGHT TO SEEK DAMAGES FROM ANY SUCH PERSON TO THE FULLEST EXTENT PERMITTED BY LAW.
8. DISCLAIMERS: Entrant agrees that Giant Step and the Promotion Parties shall not be liable for losses or injuries of any kind resulting from acceptance or possession and or use of prize(s), participation in any Contest, or any malfunctions (technical or otherwise) of the telephone network, servers, computer equipment, hardware, software, or any combination thereof, or any entries that are late, tampered with, incomplete, misdirected, lost, mutilated, delayed, corrupted, mechanically duplicated, illegible or otherwise not in compliance with these Rules. Entrant also agrees that Giant Step and the Promotion Parties are not responsible or liable for any injury or damage to an entrant's or any third party's computer related to or resulting from any Contest and its prize(s) or for damage to a user's computer system or his/her data in any way due to an entrant's participation in any Contest. Neither Giant Step nor any Promotion Party makes any representation or warranty of any kind, whether express or implied, concerning the appearance, safety or performance of any prize(s).
7. SPONSOR. Each Contest is sponsored by Giant Step and the co-sponsor(s) listed on the Contest Page in connection with such Contest.


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What we do
At Monitise, we're creating new ways for your customers to connect, interact and transact. And we're doing it by combining the latest technology with the best in intuitive design. Our products, platforms and ideas lead to smarter, better experiences, ones that help you forge closer relationships with customers.
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You can build your own products, using FINkit, our toolkit designed especially for financial services. Or use ready made products that are easy to brand and quick to roll out. Not sure, or prefer to create together? Work directly with our strategists, creatives and developers to transform your business through digital.
Whichever you choose, it's all made possible by the Monitise platform - your way to innovate quickly in a secure environment.
Monitise Content
A great way to get customers' attention on digital? Serve them with great content, whatever device they're on. We source the best offers from over 7,000 brands, including M&S, John Lewis, and Pizza Express, to keep your customers coming back for more. And we provide the analytics that keep your offers timely and relevant.


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Would you like to get away from the hustle and bustle of city life and spend a quiet day away? Well, you can and Tiburon may be the place for you.
Tiburon is a nice little town north of San Francisco, California. To get there you can simply drive your car or truck north on the Golden Gate Bridge. For directions, simply plan your trip by using GPS or printable directions to the destination of Tiburon, CA 94920.
You can also take a ferry to Tiburon from San Francisco. Check out blueandgoldfleet.com for tips on taking the ferry. Sometimes riding the ferry across the San Francisco Bay can be the most memorable part of any day trip.
How about some general information about Tiburon? Well, start your research at the website of townoftiburon.org. Next, make sure to visit and browse the websites of baycityguide.com and tripadvisor.com.
Now you don't have to spend a lot of money during your little day trip from the Bay Area to Tiburon. You can have a nice family outing, take a ferry ride, and relax the day away in Tiburon.
Make sure you take some photos of your fun in Tiburon so that everyone else can experience the joy and pleasure of your little day trip.


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The FBI has released a public service announcement regarding extortion attempts via email. From the PSA: The recipients are told that personal information, such as their name, phone number, address, credit... Read More
How to Move Files Between Your Macintosh and Your bama Account
If you are using a PC instead of a Macintosh, you need the document "How to Move Files Between Your PC and Your bama Account".
Download and Install Fetch
Fetch is a program used to copy files and directories between a PC and a remote machine. For most people on campus, this remote machine will be bama.ua.edu. You may use this to store files or publish a web site, among other things.
Skip to the next section if you find one of these icons: or
Use your Find command (command+F) to look for "Fetch". If you find it, go to the next section.
Go to the Start button, click Find, then choose Files or Folders. Search for "WS_FTP95.exe" (without the quotes). If you find it, go to the next section.
Use the Software Library to download Fetch and get its serial number. Install it, then come back to this page.
Set up Your bama Account for FTP Access
You must use a computer on the University network to do this step.This includes computers in University offices or labs and those on ResNet. This does not include home computers connected to the Internet through AOL, or another outside service provider; computers on DSL lines; or computers using cable modem connections.
As a security measures, bama accounts are not automatically given FTP access. This is to prevent outside people "hacking" into unused accounts. However, you can easily give your own account FTP access.
Go to the "Change bama Shell" Web helper. Fill in the same user name and password you use on the myBama web site, then make sure that either ftp-only or one of the "interactive" shells (ksh ,sh ,bash ,csh , or tcsh) is chosen. Most people will want ftp-only; for more information see Your Account Shell. After you have filled out the form, click the Change Shell button.
Make sure you read the message that is returned. It will tell you whether or not your shell change was successful. Some people may need to change their passwords before they are allowed to change their shells. (If you receive this message, it is probably because your account has been unused for a significant period of time. If you have a question about this policy, please call the IT Service Desk at (205) 348-5555.)
Connect to bama
When you start Fetch, the connection window below should open. (If it doesn't, go to the File menu and choose New Connection).
Fill in the fields as follows:
- Host: bama.ua.edu
- User ID: The same user name you use on the myBama web site
- Password: The same password you use on the myBama web site
Check "Add to Keychain" if you want Fetch to remember your password.
When you have finished this, you are ready to connect. Simply click OK.
NOTE: If you get a message stating that you had an invalid login and are unable to connect to your bama account, you probably either typed in your password incorrectly or did not set up FTP access on your account. Go back to the previous step, or come to the IT Service Desk in A-203 Gordon Palmer for assistance.
Transfer Your Files
First, navigate to the directories on both sides that you need to put files into or copy files from. To go down a directory level, double-click the directory name. To go up one level, double-click the green arrow at the top of the file and folder list. If you are publishing a web site, navigate to your bama account's public_html folder.
The next window is what you will use to transfer files to and from bama.
Use the folder icons to navigate to the folder on bama that you want to either put files into or copy files from. If you are publishing a web site, you should go to your public_html folder. ( More information about Web publishing.)
To copy a file or files from your Macintosh to bama:
- Use your Finder to navigate to the file(s) or folder(s) you want to copy.
- Drag the icon(s) into the Fetch window.
To copy a file or files from bama to your Macintosh:
- Highlight the file(s) in the Fetch window that you want to copy
- Drag the file(s) to the desktop (or any other folder)
When you are finished, select Quit from the File menu, or press Command+Q.
Known Issues
The Known Issues Page is a checkpoint for our IT partners across campus. The page lists software compatibility issues and known fixes.


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Merchandise > USA > WA > Seattle Area
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This book is many things: it is as much a personal thread through my days as a cancer survivor as it is a book on underwater photography – and this no fish story! This is a collection of over 100 of my favorite underwater images taken over the past 25 years. This has also turned out to be a documentary of sorts: it was sobering to realize that more species than I realized are now considered endangered.
Some of the portraits are international award winners, taken back when I entered such competitions – all before my diagnosis and recurrences of breast cancer. Other images are personal favorites or just plain interesting.
Diving and underwater photography have been longtime passions of mine, and this book is a tribute to those days when I was uncertain I'd ever get to see the ocean again. I used to lie there and mentally compose slide shows of my photography as a diversion from my treatments. It was the medicine for my soul. For those people who are battling a life-threatening illness, this book is a salute to you.
Ms. Saibara has always been an active photographer. For some 25 years, she shot underwater images, some of which won international awards, in seas around the world and are featured in her 2007 Blurb book, Forever Fish. These days, she's ditched the wetsuit in favor of land-based photography and authored 2 other photo books, Goofballs and Spain: the Costa del Sol Report. She is an advanced breast cancer survivor whose personal mantra is to live life on her terms. She earned her B.A. at Texas A&M and her Master's degree at the University of Houston. She lives in Houston, Texas. She can be reached at email@example.com
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43 Years as a Texas Aggie Football Fan Published January 12, 2010
The Costa del Sol Report Published April 02, 2008


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Jan. 17, 2013
Lakes Tennis Academy
Stonebridge Country Club
DALLAS (SMU) - The SMU Mustangs will play two matches in the Dallas-Fort Worth area this weekend against No. 26 Texas A&M and Nicholls State. The Mustangs will play the Aggies at the Lakes Tennis Academy in Frisco on Saturday, and will play Nicholls State at Stonebridge Country Club in McKinney on Sunday.
The Mustangs will look to bounce back after falling to No. 23 Texas last weekend, 5-2. The Mustangs did take the doubles portion of the match with two convincing victories over ranked pairs. Head Coach Carl Neufeld is looking forward to the opportunity to play quality opponents at high-caliber facilities this weekend.
"We're excited that two of the best country clubs in the Dallas area have decided to host our matches," Neufeld said. "We're excited about the turnout and the interest."


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Great Deals on Time Warner Cable in Fairfield
Find great deals on high speed Internet, HD TV and Phone in Ohio when you check out Time Warner Cable. Find the best Time Warner deals in OH, but hurry, they won't last! TimeWarner Cable delivers high speed Internet, no fee HD and more to Fairfield. It's never been a better time to protect your wallet with Time Warner Cable in OH.


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The ABCs are so fun to sing, read, learn and to make up words with. They can help build a child's imagination in every way.
My 4 year old helped me complete this ABC book for her and her little brother. Together, we came up with something fun and hopefully a little different then the normal ABC books.
We hope you will enjoy it!
I am a mother of two wonderfully creative children who are full of fun, games, and adventure. I am so proud to dedicate my books to them because without them I wouldn't have stories.
Comentario publicado.
Your_DaddyO dice I am so proud of you! Love. dad!
publicado a las 20 de nov. a las 15:55 PST
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The Toad in the Road Publicado 08 de octubre de 2012


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We decided to use a Christmas gift card at Carrabba's Italian Grill last weekend. Even though there are only 3 of these restaurants in Indiana, the one we visited on Southport is right off of I-65, resulting in easy access from all around Indianapolis.
The complimentary bread they served is just what you hope for when you visit any good Italian restaurant. It was a small loaf of deliciously warm, crusty Italian bread served with herbed dipping oil.
I asked the server to recommend a salad and he suggested either the Fiorucci or Johnny Rocco. I chose the latter and let me tell you, this salad is no wimpy rabbit food.
Insalata Johnny Rocco Grilled shrimp and scallops, roasted red peppers, olives and ricotta salata in vinaigrette
With the dressing on the side, this hearty and sophisticated dish was not only healthy and low in fat, but delicious and satisfying. The scallops and shrimp were still warm when placed on the bed of greens. The kalamata olives and ricotta cheese added salty and rich flavors.
On Carrabba's website, they offer several of their classic recipes for you to try, including homemade stocks, bread, tomato sauce, pesto etc. Click here to view all.
Thanks for looking and please SUBSCRIBE SPAM-FREE to my articles by clicking on the SUBSCRIBE button at the top of this page.