text:
Pangburn, Michael, Ph.D.
Contact: firstname.lastname@example.com
B.S., Chemistry, 1969, Univ. of California at Los Angeles
Ph.D., Biochemistry, 1974, Univ. of Washington at Seattle
Research Interest:
My research focuses on the part of the human innate immune system called the complement system. Complement is a system of proteins and enzymes in human blood that form our first line of defense against infections. In most cases microorganisms are attacked and killed by complement within 15 min of first contact with blood. We study the mechanisms of activation, the systems that control activation of complement, mechanisms of target identification and errors of activation that lead to disease and pathology caused by complement proteins.
Complement Technology, Inc.
Complement Technology, Inc. was formed to supply the medical research community with the highest quality reagents for complement research. It was created as a spin-off from the research program of my laboratory at the University of Texas HSC at Tyler and now operates as an independent biotech company located in Tyler, Texas. Complement Technology, Inc. is the world's primary supplier of proteins and enzymes of the human complement system. The owners and operators of Complement Technology, Inc. have a combined experience of more than 70 years in the complement field. The highly specialized reagents produced by Complement Technology, Inc. are used by medical researchers all over the world in the drug development industry, in the biotech industry and in medical research labs at universities and research foundations.
Current Projects:
- Current projects include the analysis of the proteins responsible for recognizing and initiating the attack on bacteria, viruses, parasites and fungi. How the complement system distinguishes between human cells and foreign microorganisms is not yet clear, but knowledge of how this is done is very important.
- A second but related project is the cloning and site-directed mutagenesis of one of the key proteins involved in this recognition step. By picking apart the protein we are beginning to understand why it allows an attack to proceed on microorganisms, but blocks it on our own cells and tissues. Errors by this proteins appear to lead misdirected attacks on human tissues in the diseases of age-related macular degeneration and the inherited form of hemolytic uremic syndrome. These are just a few of the known diseases where complement does not protect us as it normally does, but causes harm instead.
- A third project involves trying to measure the enzymatic properties of the central enzyme of the complement activation process - the C5 convertase. We want to understand its structure and why it is one of the slowest enzymes ever found in a biological system. Finally, we are using a new instrument, the BIAcore X, to study the interactions of each complement protein with other proteins and with enzymes with the goal of understanding how these proteins assemble into the complexes necessary for killing microoganisms.
Lay Summary:
Human blood contains an infection-fighting system of proteins called the complement system. There are over 34 proteins in this system and each performs a specific role in killing and removing bacteria, viruses, parasites and fungi (yeast infections) from our bodies. I have been studying these proteins for 32 years. My work involves purifying each protein from outdated plasma that we get from the local blood bank. Recently we have been getting some of these proteins by cloning DNA. We then mix certain components back together and try to learn which ones work together, how they combine and how they kill infectious organisms. We are also trying to understand why the complement system sometimes attacks our own tissues, such as in autoimmune diseases and after strokes or heart attacks where as much as half of the tissue damage can be caused by complement. We are using the knowledge gained about complement to develop drugs to stop the system when an attack is misdirected at our own tissues.
Research Overview:
Human blood contains many systems for fighting disease. One of the major systems for killing microorganisms such as bacteria, yeasts, viruses and parasites is referred to as the "complement system." This system got its name from the discovery over 90 years ago that antibodies alone could not kill bacteria. These same antibodies, however, mixed with non-immune plasma could kill. Thus it was said that something in the plasma "complemented" the antibodies. We now know that this system is made up of more than 34 different proteins that circulate in plasma or reside on cells. These proteins each have different functions in combating infections and in maintaining a normal immune response to antigens. My research is centered on understanding how each of these proteins performs its disease fighting role and why the destructive power of the complement system occasionally is directed at human tissues. The main focus of the lab is the alternative pathway of complement activation. This pathway of activation provides the host with an innate system of defense against infectious agents because it is capable of neutralizing a variety of potential pathogens on contact, prior to the production of antibodies. To investigate these reactions many of the proteins of the complement system are purified and used to analyze protein-protein interactions, to study mechanisms of activation and to understand how each of these reactions contributes to the overall process leading to killing of infectious organisms. Also in use are techniques of molecular biology to mutagenize and express complement proteins in order to study structural features which perform critical functions. Finally, my laboratory is interested in the development of drugs which would allow physicians to control the complement system. Recently the first drug that controls the complement system was approved for use in humans for the treatment of PNH and it has had dramatic results. Many drugs are currently at various stages of development by many drug companies for either suppressing or enhancing the complement system.
Selected Papers and Abstracts:
- Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 80:165-73, 2011.
- Cortes C, Ferreira VP, Pangburn MK. Native properdin binds to Chlamydia pneumoniae and promotes complement activation. Infect. Immun. 79:724-31,2011.
- Hammond DJ, Singh SK, Thompson JA, Beeler BW, Rusinol AE, Pangburn MK, Potempa LA, Agrawal A. Identification of acidic pH-dependent ligands of pentameric C-reactive protein. J. Biol. Chem. 285:36235-36244, 2010.
- Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A targeted Inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv. Exp. Med. Biol. 703:137-49, 2010.
- Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina, H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J. Immunol. 185:3086-3094, 2010.
- Agarwal S, Ferreira VF, Cortes C, Pangburn MK, Rice PA, Ram S. An evaluation of the role of properdin in alternative pathway activation on Neisseria meningitides and Neisseria gonorrhoeae. J. Immunol. 185:507-516, 2010.
- Ferreira VP, Cortes C, Pangburn MK. Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology 215:932-940, 2010.
- Ferreira VP, Pangburn MK, Cortes C. Complement control protein factor H: the good, the bad and the inadequate. Mol. Immunol. 47:2187-2197, 2010.
- Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury. J. Biol. Chem. 284: 16939-47, 2009.
- Ferreira VP, Herbert AP, Cortés C, McKee KA, Blaum BS, Esswein ST, Uhrín D, Barlow PN, Pangburn MK, Kavanagh D. The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J Immunol. 182: 7009-7018, 2009.
- Pangburn MK, Rawal N, Cortes C, Alam MN, Ferreira VP, Atkinson MAL. Polyanion-induced self association of complement factor H. J. Immunol., 182:1061-1068, 2009.
- Pangburn MK, Ferreira VP, Cortes C. Discrimination between host and pathogens by the complement system. Vaccine, 26S:115-121, 2008.
- Fritzinger DC, Hew BE, Thorne M, Pangburn MK, Janssen BJ, Gros P, Vogel CW. Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion. Dev Comp Immunol. 2008 Aug 27. [Epub ahead of print]
- Hocking HG, Herbert AP, Kavanagh D, Soares DC, Ferreira VP, Pangburn, MK, Uhrin D, Barlow PN. Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations. J. Biol. Chem. 283: 9475-9487, 2008.
- Ferreira VP, Pangburn MK. Factor H mediated cell surface protection from complement is critical for the survival of PNH erythrocytes. Blood 110:2190-2, 2007.
- Herbert AP, Deakin JA, Schmidt CQ, Blaum BS, Egan C, Ferreira VP, Pangburn MK, Lyon M, Uhrin D, Barlow PN. Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism. J. Biol. Chem. 282: 18960-8, 2007.
- Rawal N, Pangburn MK. Role of the C3b-binding site on C4b-binding protein in regulating classical pathway C5 convertase. Mol. Immunology 44: 1105-1114, 2007.


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As president of M.Y.T.H. Inc., Skeeve is in charge of a myth-chievous gang that includes a pet dragon and an artistic vampire. However, is it just luck (of the bad variety) or deliberate myth-directions that have Skeeve and his gang sleuthing around some very out-of-the-way (and dangerous) dimensions?
©2006 Robert Lynn Asprin (P)2013 Audible, Inc.
"Loving R. Aspirin"
I especially loved Gleep in this book. It reminded me of how much we love our pets.
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subset: commoncrawl


text:
UMass sophomore Freddie Riley scored 30 points last night as the Springfield Slamm lost in Pro-Am Basketball, 125-118 to the Fairview All-Stars. Riley nailed four 3-pointers including three in a row in the first half. Fellow Minuteman Sampson Carter had 10 points and five rebounds. The Springfield Republican has a small story on the game.
Riley Nets 30 In Summer Pro-Am Game
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"We don't inherit the planet from our parents;
we borrow it from our children."
- proverb
Going green is not just a trend, but a lasting way of thought and action—blue is the new green. Here are the easiest and smartest ways you can make a difference to the health of the planet, including buying fuel-efficient vehicles, choosing energy-saving appliances, exploring the aquatic world, choosing ocean-friendly seafood and actively supporting the Aquarium's conservation efforts.
The way we each live our lives contributes heavily to climate change. We have the ability to make a huge difference in the health of our planet. Transportation accounts for nearly 30 percent of U.S. annual carbon dioxide emissions, and another 30 to 40 percent comes from power plants and the use of electricity. A major portion of the rest comes from the energy used to heat and cool buildings. Therefore, the way we travel and use energy in our homes and offices makes a huge impact. Here are some of the ways you can help reduce your carbon emissions on a daily basis.
Reduce your carbon footprint—live blue™!
The next time you buy a car, choose one that is highly fuel-efficient – or at least more fuel-efficient than the one you had before. Your choice of vehicle is probably your most important decision. For every gallon of gasoline burned, 20 pounds of carbon dioxide go into the atmosphere.
Choose to join a carpool, walk, bike or take public transportation whenever practical. And support local initiatives to make these alternatives more widely available and safe.
Install energy-saving thermostats, light bulbs and appliances in your home. You can tell the appliance is energy saving by looking for the Energy Star designation, awarded by the Environmental Protection Agency. Your furnace and air conditioner are likely to be the biggest carbon emitters in your home. When you replace them, install the most efficient models you can afford. These measures will not only help you cut your carbon emissions, they will save you money too. Most will pay for themselves within just a few years.
Measure your personal carbon emissions by using a carbon calculator and then track how the changes you make reduce your emissions over time. These tools now are available on many websites such as the National Grid's Floe. Once you've set your conservation goals, you can use Energy Star, the American Council for an Energy Efficient Economy and the Union of Concerned Scientists publications to get more energy conservation tips. Share your results and strategies for living blue on New Dream.
Stay informed by signing up for the Seabits newsletter from the Aquarium or the Ocean Project's monthly ocean newsletter on ocean actions. Keep conservation issues on your mind when you vote. You can contact your congressional representative and senators to encourage them to support actions to address global climate change. You can do simple things in your community such as urge local businesses, libraries, churches, and synagogues to install bike racks and promote community carpooling plans and the construction of bike lanes.
Use your consumer power—learn about the environmental practices of the companies you buy from. For example, encourage your electricity provider to provide clean, renewable energy sources such as solar and wind. Look for labels on the products you buy that indicate whether the company producing them has taken its carbon footprint into consideration. And inspire your friends to take action.
10 things you can do to make a difference
It's easy to make a difference for the oceans by making small changes in your daily life. Here are some of the things you can do to help our environment. We hope this list inspires you, your family and friends to take action, because our combined efforts can—and do—make a difference.
Support the Aquarium's conservation efforts
With your help, we rescue marine animals across New England, conserve endangered species and work to preserve and restore marine habitats around the world. Together, we are a force for change. Help us save the oceans today. For example, support our efforts to help coral reefs cope with climate change, right whales to survive, and membership efforts and exhibits that support a sustainable planet.
Read blue
Become an Aquarium member to receive a free subscription to blue, our quarterly members' magazine. Enjoy feature articles on how to live blue™, exciting recaps of Aquarium expeditions, fun and educational activities for kids and more.
Explore the aquatic world
The more you know about the aquatic world, the better prepared you will be to help protect it. Visit the Aquarium to meet the animals and explore their exhibits. Take advantage of family activities at the Aquarium. Attend a free evening lecture to learn more about marine biology and current conservation issues, or enroll your child in an Aquarium Family Program or Harbor Discoveries Summer Camp. You can also live blue™ at your dinner table with ocean-friendly seafood recipes from the Aquarium's Celebrate Seafood Dinner Series.
Eat ocean-friendly seafood
Your seafood choices matter. Explore our list of sustainable seafood options, try a new recipe at home or join us for a casual seafood lunch or three-course dinner. Learn more from the Aquarium's Celebrate Seafood Program.
Events Calendar
Come see what's happening


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Now that they're six, they're as clever as clever. And that means they need great toys that challenge, entertain, and teach [all at the same time]. Amazing activities, art kits, and all kinds of construction sets will have them learning more than they'll even know.
Meet Princess Elisa. She is wearing a pretty, pink and purple dress with beautiful details and lots of ruffles. Princess Elisa has brown hair, dark eyes, and a kind face. She will make the perfect addition to your Papo collection – have her attend a ball and meet other Papo figures (they will adore her dress), or maybe she will save her beloved knight from a scary dragon! The ending is up to you!
Papo toys lead the way to worlds full of wonder with beautifully crafted, hand-painted figurines. There's something for everyone!
Measures approximately 3.5" tall x 3" long x 1.5" wide.
This ferocious dragon breathes icy fire to defend against its enemies! This fantastic creature can only be defeated by the bravest of your Papo knights (sold separately )
Measures approximately 7" long.
Ride into battle on this sturdy war horse! The horse is dressed to impress with white and gold trappings. Add his matching rider, White King Richard Figure (sold separately) to complete the fearsome set.
Measures approximately 6" long.
Knight figure sold separately.
King Richard defends the realm dressed in white and gold. The lions on his shield and jerkin represent his courage in battle; this Papo figure is one you'll want to lead your army when the fighting starts!
Measures approximately 3.5" tall.
This fearsome Winged warrior is ready for battle! Perched atop his brave steed, he terrifies opponents with his red armour and giant wings! This duo is an awesome addition to your Papo Fantasy collection!
Measures approximately 5.5" long.
This Papo knight is an impressive figure with golden armour covering him from head to toe. The brave warrior wields a notched sword, carries a golden shield, and wears a bright red plume on his helmet. This is one knight you definitely want to have on your side going into battle.
Measures approximately 4" tall x 3.5" long x 2" wide.
Just like Diana, the Roman goddess of the hunt and the moon, our Huntress lives in harmony with nature. The woodlands and the mountains are her kingdom. Armed with a bow and arrow, she hunts for food wearing a green dress with a purple underdress.
Papo figures are made of high-quality materials and feature beautiful details to encourage creative and imaginative play in children. Add the Huntress figure to your Papo collection!
Measures approximately 2.5" long x 4.5" tall x 2.5" wide.
Ride into battle on this sturdy war horse! The horse is dressed to impress with black and gold trappings. Add his matching rider, the Black Horseman with Axe (sold separately) to complete the fearsome set. Papo figures are extremely detailed, and inspire creativity and imaginative play. Add the Horse of the Black Horseman to your Papo collection today!
Knight sold separately.
This impressive knight wields a terrible axe when he goes into battle. His name, The Black Horseman, comes from the armour he wears which is black with golden accents. He can fight on his own, and also from the back of his trusty steed (sold separately). Papo figures are extremely detailed, and inspire creativity and imaginative play. Add the Black Horseman to your Papo collection today!
Horse sold separately.
The Safari Limited Dragon Good Luck Mini figure is the perfect size to tuck into pocket or wallet, for fun on the go! This miniature features incredibly fine detail, from his twisted, scaly tail to his shining gold-painted tongue and eyes! This tiny figurine is expertly crafted and painted to look just like a storybook dragon!
Safari Limited has earned a reputation for creating the most realistic, to-scale plastic models available today. Their sculptors work closely with zoos and museums to create incredibly detailed, lifelike molds from which each small plastic model is made. Safari Limited products also conform to the highest safety standards, and the plastics and paints used on each model are tested regularly to ensure that they are not hazardous or toxic to children. Experience the excellence that Safari Limited has to offer with this beautiful, fun-to-play-with plastic model!
Measures approximately 1.5" long.
Drawing is awesome!
What do you want to draw today? A truck? A flower? A tree? If you can draw squiggles and simple shapes, then you can draw anything you want. It's easy … and fun! How about a volcano, a ladybug, a medieval castle, or a T-Rex? Why not a wizard, a pirate, or a princess? This book shows you how. Contains 47 pages.
Defend the kingdom with the Secret Dragon Fort! With two blue dragons, this fort is well protected against any enemies. The fortified gate makes it almost impossible to break in while the turreted crossbow with flaming arrows tilts and rotates for the perfect aim! The precious dragon fire illuminates blue!
Includes two figures, helmets, shields and assorted battle gear, torches, flags and other accessories.
Figures measure approximately 2.95" tall.
Requires 1 AAA battery (sold separately).
Scare away enemies with the Giant Battle Dragon with LED Fire! This huge black, red and orange dragon towers over his opponents! Enemies will shy away from this dragon when they see him breathe fire, which lights up orange!
Includes battle dragon, one figure, helmet and other accessories.
Figure measures approximately 2.95" tall.
Requires 1 CR 2032 3V button cell battery (included).
Ward off attacks with the fierce Flame Dragon! This large orange dragon features bright red wings, flaming red tongue and horns and is ready to defend against enemies!
Includes flame dragon, one figure, bow and arrow, shield and other accessories.
Be prepared and win the next battle with the Shield Dragon! Kids will enjoy fending off enemies with the bright blue dragon and functioning crossbow! All enemies of the Shield Dragon are sure to surrender once they see this ferocious beast breathing fire!
Includes Shield Dragon, one figure, flag, helmet, sword, torch and other accessories.
This four-piece hand-puppet set includes a royal collection of characters! Designed to help children and caregivers role-play together in a sweet and simple way, the prince, princess, knight, and dragon are sure to inspire countless creative stories and amazing imaginary adventures. The simple glove puppets fit children and adults and are easy to use, so even the littlest puppeteers can see exciting movement with very little skill - terrific for self-confidence, and also an invaluable booster for motor skills, hand-eye coordination, communication skills, parent-child bonding, and so much more! Made with brightly patterned, washable fabrics and built to last, these soft and sweet hand puppets are sure to be go-to toys for years to come.
Includes 4 puppets.
We are excited to announce that our annual sale of top-quality toys and books at great discount prices will be happening at the International Centre in Mississauga, Wednesday July 13 to Sunday July 17, 2016!
We're hiring! For over 30 years Mastermind Toys has been focused on offering the very best in quality toys and books for children in a shopping environment that is engaging, inspiring and fun. Send resumes to firstname.lastname@example.com
Mastermind Toys in the Terra Losa Shopping Centre is now open.
Details Here


text:
up in the air by dannielle-leeWatch
©2013-2016 dannielle-lee
Features; 30 Seconds to Mars Inverted Triad
Graphic type; desktop wallpack
Date made; May 25, 2013
Made using; Paint Shop Pro X5
Read; Terms and Conditions
Image(s); thirtysecondstomars
Brushes, png sets and/or textures are in my favorites, my gallery or in my favorites at brusheezydotcom.
Notes; This one is pretty old. Man I'm such a slacker.
+ If you download, please it. Thank you and enjoy.


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Local anglers have been dodging rain showers and getting in some decent fishing.
Temperatures have remained steady enough that real fall fishing hasn't kicked into gear yet, although the speckled trout don't seem to know to wait and have been hitting well. Red drum and flounder are making up the bulk of the other inshore catches as folks wait for the spot to start running.
On Saturday, Sept. 26, fishermen will gather to support one of their own at the third annual Bay Creek Classic Flounder Tournament.
We've had our first showing of spot on the piers, and anglers are poised for the big fall spot run.
Last year was a disappointment, but there seems to be good signs this season will be better. Fall pier fishing remains a simple and rewarding fishing experience that brings out the kid in all of us.
The recent dip into autumn-like temperatures had anglers hoping fish would start gearing up for the fall runs. That didn't exactly happen, but we are still seeing good fishing with quite a few big flounder, redfish and trout now out there around their usual inshore haunts.
If fishing is this good now, it is possible this fall season will make up for last year's disappointments.
When Mother Nature flipped the switch, she did not hold back. It has gone from summer to fall in a hurry, and I am not complaining.
The mullet have been running the beach and the menhaden schools are lined up along the beachfront from Ocean Isle Beach to the Cape Fear. All the pieces are in place for one of the best fall king mackerel bites we've seen in years.
Flounder fishing really picked up in late August, and the tasty flatfish are the hottest bite out there right now. There are plenty of stocky redfish biting, and Spanish mackerel are hitting along the shore in the early mornings, but it is the flounder that have local anglers the most excited. Fishing for flounder should continue to be strong right through the fall.
I have dusted off my blue jeans and unboxed my sweatshirts. I have my reels spooled and hooks sharp. The time is near for fall fishing to begin.
The last couple of weeks the offshore fishing has not been incredible. We have been catching plenty of Spanish mackerel, amberjack and barracuda, but when it comes to the king mackerel and grouper, the fishing has just been plain tough. Much of this due to an anomaly known as a thermocline that formed about three weeks ago.
Fishing is turning out to be a bit better than I expected. Anglers haven't been waiting for the fall but are filling up coolers with some nice fish despite the bad reputation of the late summer season. Flounder, redfish and black drum have all being biting for local fishermen.
One reason may be the influence of Hurricane Bill, which roared by from a distance last week but caused some significant waves and pounded on the beaches. This wouldn't be the first time the original storm of the hurricane season put the fish in a biting mood.
Local saltwater fishing is still stuck in a summertime pattern, as the game fish are not plentiful but are nice-sized and most of the action is in the morning or at night. Something not in short supply are the baitfish and shrimp, which are swarming through our waters right now.
August is not considered one of the better months to fish from this area. The summer's heat builds to a peak, which raises water temperatures above 80 degrees and typically sends the majority of fish either packing north or offshore. However, this August is showing if food is readily available, the predator fish will endure a bit of discomfort for a guaranteed meal.
I hate to harp on it, but the pogies are absolutely thick all along the beaches, and it is helping our fishing exponentially.
Copyright © 2016
The Brunswick Beacon is your source for local news, sports, events and information in Brunswick County, North Carolina and surrounding areas.


text:
Per his Twitter. https://twitter.com/AllenLazard
Printable View
Per his Twitter. https://twitter.com/AllenLazard
atta boi. makin a pimp decision!
seriously CPR doing some work with recruiting the last few weeks.
WOW.. What a week for ISU football recruiting.
This is a HUGE get.
HE's 6'5"!!!!
4 star on rivals....
i heard he's soft though:jimlad:
I take a minute to find a picture and I go from the second post to the 10th! HA! GO CYCLONES!
I wonder if that's why Shane Burnham tweeted this earlier today:
Coach Shane Burnham @ShaneBurnham52
HUGE DAY!!!!!!! Can't begin to describe how excited I am about what's happening here at Iowa State.#cyclONEnation#NotYourFathersIowaState
Usually he does after a huge commitment.
Our last two commits?
4 stars.
And as Andy Fales has said - the tide hasn't completely turned, but times are a changin'. We are winning the in-state recruits.


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The U.S. Dollar and the Japanese Yen benefitted from risk aversion in the free Forex which occurred as the U.S. Congressional super-committee failed to agree on deficit cuts.
Meanwhile, the Euro slipped as Spain became the fifth European nation to replace their socialist party due to the debt crisis. Mariano Rajoy, leader of the People's Party, beat the candidate for the socialist party, Alfredo Perez Rubalcaba. Traders are said to be paying record highs for the right to sell the 17-nation currency; according to analysts, this may be a sign that the Euro will continue to decline amidst worries that the Euro region will not be able to contain the debt crisis. The shared currency dipped further as Moody's Rating Agency warned France it may lose its AAA credit rating given the hike in borrowing costs.
Other FX news showed that the Pound Sterling slipped to a one-month low against the greenback after metrics revealed that U.K. home prices declined the most in one year on concerns that the economy in the country is deteriorating. The British currency slumped versus the Yen after Prime Minister David Cameron stated that Great Britain is "well behind" where it ought to be in regards to economic growth.
The Canadian Dollar also declined as the U.S. failed to produce an agreement to reduce the deficit. Lastly, the New Zealand Dollar dipped the most in one month as the budget impasse dampened demand for risk in the currency market.
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On-demand computing models support Web application scalability
By Jason Tee
The on-demand nature of cloud computing has put scalable Web applications within easy reach for businesses of all sizes. There's little to no barrier to entry for even the smallest companies to access the kind of computing power and data storage that was once only available to enterprise customers. It's not just cheaper than ever to get all the server space you want – it's also easier. The cloud has made ordering up more resources as simple as ordering a fast food meal at a drive through.
However, just because a business can now "supersize" its infrastructure in the cloud doesn't mean IT should just keep hitting the button to order more resources. Low-cost isn't no-cost. Many businesses find out the hard way that simply making the switch to a cloud-based infrastructure doesn't save them nearly as much as they anticipated.
"On-demand" billing that is usage-based may seem fair and easy to understand. But this approach still requires careful planning about how and why to use resources. Otherwise, a business can get stuck in a cycle of using far more resources than necessary without even realizing it. Scaling up our out isn't the answer to every system slowdown or failure caused by a heavy workload. Most bottlenecks in performance can be addressed in other ways.
Questions to ask before scaling with the cloud
- Do you really need more cloud server space to achieve greater computing power, or do you really need to streamline your existing server use with appropriate load balancing?
- Do you need a larger or different platform, or just ways to make better use of your existing databases?
- Do you need to deploy more instances of your application, or should you redesign your app to use fewer resources?
The 'cloudy' financial mindset
One of the pitfalls of cloud computing is the ease with which decision makers get in the habit of using extra resources when they are billed as a service. Compared to the cost of building out more on-site infrastructure, those monthly charges look tiny – and each incremental increase seems so reasonable and affordable. This kind of recurring business expense becomes more and more palatable over time, even when it's bleeding the budget dry.
It may seem more difficult to justify the up-front expense of a full analysis and revamp of how existing resources are employed. But this approach can actually lead to immediate and ongoing savings. For example, if you find ways to increase the effectiveness of your existing resources by 20%, that's not just 20% fewer cloud resources you'll need to add to your monthly IaaS or PaaS bill right now. When you do scale up to add more cloud resources, you could be using those added resources at 20% greater efficiency as well.
In contrast, consider what happens when applications and databases are not designed to scale up well. The amount of computing resources required to maintain acceptable performance may rise much faster than expected when scaling to meet a substantial increase in demand. That's fine with the cloud providers. It's just more money in their pocket when applications eat up more resources than necessary. It's up to the in-house developers to take control of the efficiency of business applications by fixing code and optimizing database queries before deployment in the cloud.
Let's talk about scaling back
On-demand scalability theoretically implies the ability to cut back usage of cloud resources during times of low demand. Sadly, this doesn't always happen. Load balancing is designed to spread workload among many different nodes in the most efficient manner possible. But during low traffic times there will be some servers (or instances) that don't need to be used at all.
The drop in traffic should trigger the process of "bleeding off" connections so that no additional requests are distributed to these servers/instances. The load balancer would simply allow current users to finish up any activity and then automatically de-provision the servers or instances that are no longer required.
This is an important topic to discuss with potential cloud providers. Is the de-provisioning process manual or automated? Can the de-provisioning protocol be configured to meet custom requirements – or is there just one out-of-the-box solution for automation? The more control over how and when resources are automatically scaled back stays in-house, the better.
With either automatic or manual scaling, there can still be costly surprises if an organization does not monitor cloud usage daily. For example, IT staff might provision additional resources for a particular high volume event and then forget to de-provision afterward. Or, a DDoS attack could spike cloud costs by ramping up usage very suddenly. It may be worth considering automated cloud usage tracking software to help control spending and keep cloud service charges from spiraling out of control.
It's definitely possible to save money in the cloud , but doing so requires careful planning and thorough research.
10 May 2012
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Phone: (852) 2358-7680
Fax: (852) 2358-1749
Email: firstname.lastname@example.com
Mailing Address:
Kalok Chan
Hong Kong Univ. of Science and Tech.
Department of Finance
Clear Water Bay - Kowloon
Hong Kong
Official Home Page
Personal Home Page
Primary Area of Interest: Microstructure
Has done key work on microstructure implications due to informational asymmetry


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|This page needs to be cleaned up to meet the standards of Grand Theft Wiki.
Patrick (far left), Derrick (left), Maureen (centre) and Kate McReary (far right) with Niko Bellic (centre right) at the funeral of Francis McReary.
|Patrick McReary
|I'll Take Her
|Unlocked by
|Blood Brothers
Undertaker is a mission in Grand Theft Auto IV, triggered by a phone call from Patrick "Packie" McReary; it is one of several missions in the game that commits Niko without player choice. After the Mission Blood Brothers, Packie calls Niko about the death of one of his brothers (either Francis or Derrick depending on who the player chose) and asks him to attend the funeral at the unnamed church in Suffolk. Niko decides to go.
Packie tells Niko to dress in a suit (can be found at Perseus if Niko doesn't already own one at a safehouse) and Kate will call you a few minutes later asking if Niko is attending the funeral (if Niko is already wearing a suit he won't be able to head to the church until Kate calls). Before heading to the marker the player should head to gun shop to stock up on ammo and armor to make the mission easier. As the group are leaving the church they'll come under fire by three waves of four Albanians hoods coming in cars from the sides and from the middle alley. The player must kill them all before they destroy the hearse carrying one of the McReary Brothers. After killing all of them the player will have to drive to the cemetery (varies on who you killed; Colony Island for Francis and Steinway for Derrick; Steinway being generally the easier of the two destinations to reach due to the convoluted access roads onto Colony Island) with a final car of Albanian hoods in pursuit and a two-star wanted level. They'll again have to protect the hearse and if the back door pops open or is open the player will have to watch their speed so the casket doesn't fall out.
At some point after the mission ends, Niko receives a phone call from Gerald McReary unlocking the I'll Take Her mission, and a call from Packie which comes with an approval rating boost. Francis, meanwhile, will send a hypocritical e-mail to Niko later on "mourning" his brother, and also providing Niko with a link to the LCPD's criminal database website (although the player will have likely already found it).
- This is the only chance to get a Romero in the game. Immediately after completion of the mission, the Romero can be seen driven away followed by a black Washington. Snipe the Romero driver, and the Romero is free to take. Another way to obtain it is this following: immediate after the cut scene by the graveside is finished, you will be standing facing the Romero, which is about to drive off. If you run after it at this point you should have enough time to get by the passenger side of the vehicle and carjack it. Upon driving it to one of your safehouses, more Romeros will begin to spawn in traffic, making it possible to get more than one Romero if one spawns in traffic near your safehouse. Note that the player must kill the Romero driver or else the Romero won't save properly at a safehouse. Also, strangely, if you killed Playboy X and befriended Dwayne Forge during The Holland Play, and chase down, shoot and kill the Romero driver at the end of the mission, Dwayne's "like" percentage will go down.
- If the coffin is damaged enough in the Romero, you can see the body in it.
- The coffin variant of the Romero is not available after this mission.
- If you kill Francis, there will be cops at his funeral, however they disappear when the Albanians show up. If you kill Derrick they will all be random peds in nice clothing.
- The gravestone that is created at the end of the mission is not solid - the player can walk or drive through it.
- If you destroy any of the vehicles leaving the scene after the mission is completed, a gangster/ the driver in the Washington may pull up and start fighting.
- During the initial gunfight, if one or both of the vehicles parked behind the Romero survive, Packie will be seen ordering drivers to get out of there. If the vehicles are destroyed Packie just asks Niko to drive the Romero.
- Defeating the gangsters outside the church is fairly easy with a rocket launcher though care must be taken not to destroy the Romero or kill Packie with splash damage.
- If Francis is alive, his "remove wanted level" service is disabled during this mission.
Niko Bellic fighting off the Albanian attackers.
Niko Bellic fighting off more Albanian attackers.
Niko Bellic driving the hearse to the cemetery.
Niko Bellic driving the hearse away from the pursuing Albanian attackers.
Niko Bellic driving the hearse away from the pursuing Albanian attackers and the police.
The body of Derrick or Francis McReary being buried.
Niko Bellic talking to Kate McReary at the cemetery.


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Bon Jovi drummer Tico Torres has undergone emergency surgery for the second time in a fortnight, according to reports.
08:51, UK, Tuesday 24 September 2013
Tico Torres, the 59-year-old drummer with Bon Jovi, has been rushed into hospital for the second critical operation in two weeks.
The musician had his gallbladder removed after suffering severe pain in his abdomen.
The week before last, Torres had his appendix taken out in Mexico City, causing the band to postpone gigs.
They will now go ahead with their scheduled tour dates with replacement drummer Rich Scannella.
Torres expressed disappointment that he would not be performing in the near future, but promised in a statement that he would "be there in spirit and back on stage soon".
"I would like to say a quick 'Thank You' to all of you who have kept me in your thoughts thus far," he wrote.
Bon Jovi said in a statement: "Tico Torres has been the heart and soul of our band since we started 30 years ago.
"He's also one tough SOB and we look forward to him again pounding away brilliantly at the drums on (the) remainder of this and future tours."
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Paso Robles is known as wine country yet there is much more.
The historic Salinan Indians were the first to discover the benefits of the thermal mineral-laden springs in Paso Robles. They called it "Heaven's Spot" because of its health benefits.
The benefits of soaking in hot springs stem from combining the hot water temperature and its mineral content. This helps the body get rid of toxins, increase circulation, relax muscles, act as a calming influence and more.
Before California became a state, mission records showed the Spanish missionaries traveled to Paso Robles every year to bathe in the hot springs.
Throughout the years John Wayne, Clark Gable, Judy Garland, Herbert Hoover and many others from around the world stayed at the Paso Robles Inn to indulge in the hot springs.
The mineral spa tradition has continued.
Today you can relax in a thermal mineral-laden spring's bath and gain the health benefits without leaving your hotel room.
The sulfur, filled with a high mineral content, is naturally heated deep under the earth and brought up to the rooms. Most hot springs boast of their healthy benefits for the body.
The Paso Robles Inn is unique because they have private mineral hot springs therapy spas inside several of the guestrooms.
On the first floor, the spa is inside the rooms and those on the ground floor have enclosed spa patios.
You can take any of the paths that wind around the gardens, over the bridges and to the Koi-Filled pond.
Their swimming pool and Jacuzzi are near the large oak and olive trees which were planted in the 1800's.
The lobby is designed with wooden beams across the high ceiling to have the "feeling" and "look" of the past. Just above the front desk, you can see a mural of the original building in the 1800's.
Several other historical pictures adorn the walls around the main building.
Since the Paso Robles Inn is in wine country, the owners arranged to have 18 winery-themed rooms decorated by different wineries. When entering any of these colorful rooms, the guests are surprised to receive a wrapped bottle of wine and glass as a gift from that winery. There is also a card for a complimentary glass of wine when dining in the Paso Robles Inn's Steakhouse Restaurant or Cattlemen's Lounge.
The Paso Robles Inn offers a choice of traditional guestrooms, garden fireplace rooms, deluxe mineral spa rooms, deluxe mineral spa garden rooms and suites.
Anyone wishing to learn about the history of the Paso Robles Inn can arrange a tour. The Paso Robles Inn is in downtown Paso Robles, in wine country, halfway between Los Angeles and San Francisco on California's Central Coast.


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About Civil
Founded in 2000, Civil Construction, LLC ("Civil") has been a leader in the Washington, DC metropolitan area in large construction projects involving roadway, sidewalk, parking lot, and bridge paving and repair.
Civil also enjoys a strong reputation for its work on underground utilities, storm drainage systems, streetscapes, roadway electrical, traffic signal and signage, and excavation projects.
Priority #1: Safety
Whether the project is big or small, safety is always Civil's top priority. Civil is committed to maintaining the highest safety standards on its jobs to ensure the well being of its employees, contractors, and members of the community.
Featured Projects
Conn. Ave. Underpass at Dupont Circle
Concrete Paving in Tunnel, Granite Curb, Underground Utilities, Traffic Signalization, Asphalt Paving
Watts Branch Trail b/t Minn. Ave. & 63rd St. NE
Asphalt Walking Trail, 2 Pedestrian Bridges, Road Crosswalks, Lighting, Tree Excavation
F Street NW from 17th to 23rd Street
Roadway Replacement, Underground Utilities, Granite Curb, Brick Gutter, Brick Paver Sidewalks
Thomas Circle, Northwest, Washington, DC
Concrete Sidewalk Replacement, Brick Pavers, Granite Curb, Brick Gutter, Underground Utilities, Asphalt Paving
Perimeter Site Security (World Bank)
Installation of Bollards, Concrete Pavers, Granite Curb, Arm Barriers
Columbia Heights Streetscape
Asphalt Paving, Underground Utilities, Granite Curb, Concrete Gutter, Electrical, Brick and Granite Pavers, Granite Benches, Concrete Sidewalks and Driveway Entrances, Fountain Tile Work, Landscaping


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Oven Fried Zucchini Chips
Total Time
Prep 15 mins
Cook 10 mins
These are so tasty. Points 1.
Ingredients Nutrition
- 3 medium zucchini
- 1⁄4 cup frozen egg substitute, thawed
- 2 tablespoons commercial reduced-calorie Italian dressing
- 1⁄2 cup fine dry breadcrumb
- 2 tablespoons grated parmesan cheese
- 1⁄8 teaspoon fresh ground pepper
- vegetable oil cooking spray
- Cut zucchini into 1/4 inch thick slices; set aside.
- Combine egg substitute and Italian dressing in a small bowl, stir well.
- Combine bread crumbs,
- Parmesan cheese and pepper in a small bowl; stir well.
- Dip zucchini in egg mixture, dredge in bread crumb mixture.
- Place zucchini on a baking sheet coated with cooking spray.
- Bake at 475 degrees for 5 minutes, turn and bake an additional 5 minutes or until golden.
- Serve immediately.
Most Helpful
I'd give these more stars if I could. We love them and make them regularly. They take a bit of time to prepare, but well worth the effort!
Yummy! Summer is here and the gardens are overflowing. Wanted something different from my usual steam or saute without using a lot of points. This was perfect. I used an egg white in lieu of the egg substitute and it worked just fine. Nice crispy coating, good flavor and tender squash. Served mine with a 0-point fresh tomato-basil bruschetta topping. Thanks.
Yummy! We dipped these in ranch dressing and they were delicious! The only thing I did differently was use egg whites instead of the egg substitute. These would work well as an appetizer (with the ranch dressing as dip), or as a side dish. Thanks Dancer!


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Operation and Controls
The Panasonic Lumix DMC-GX1 offers a unique handling and operational experience, not out of sheer innovation, but in large part due to its combination of internal specs and external design found in the G3 and GF1 models respectively. The AF system is fast and reliable; among the best we've seen from any G-series model. The abundance of external control points along with a responsive and intuitive touchscreen interface make the GX1 a very pleasant camera to use, whether you are changing exposure settings between shots or tweaking menu options to tailor the camera's behavior to your liking. Users of any current G-series camera will feel right at home navigating the camera's menu structure which is laid out in a sensible, if not particularly efficient tab-based multiple page interface. Yet, with so may options that can be accessed either through the Q.Menu or one of four Fn buttons, trips to the menu system can be relatively infrequent.
Top of camera controls
Along the GX1's top plate lay the mode dial and power switch, in an arrangement identical to that found on the G3. Both controls offer resistance stiff enough to minimize inadvertent actuation when handling the camera. The shutter button provides positive feedback upon a half-press and the movie record button, while positioned very near to the shutter release is recessed into the camera plate to avoid accidental operation. The i(intelligent)Auto button toggles between the shooting mode currently set on the camera dial and either standard iAuto or iAuto Plus, depending on how its menu option has been configured.
Rear of camera controls
The rear of the camera offers a multitude of control points surrounding a familiar 3.0 inch 460,000 dot LCD, with the thumb wheel, AF/AE lock and playback controls most easily accessible with your hand in the shooting position. The thumb wheel copies the smaller diameter design found on the G3, and thus requires slightly more rotations when navigating through page-heavy menu screens. This is by no means a huge issue, but around the dpreview office, those used to larger thumb dials felt a noticeable difference.
The 4-way controller continues with recent Panasonic tradition (with the notable exception of the GF3 and its integrated dial) with ISO, WB, drive mode and AF mode controls surrounding the menu button. The AF/MF focus mode button makes a return, having been shelved after the GF1 was replaced.
The metal buttons and 4-way controller mimic those in Panasonic's premium compact models, like the Lumix DMC-LX5, right down to the silver-on-silver button labelling which is impossible to read in low light. We are thankful the GX1's buttons have not also been subjected to the same degree of miniaturization. Nevertheless, users migrating from the GF1 will find noticeably smaller control points on the GX1. In addition, its Fn1, Disp., Q.Menu and AF/MF buttons all sit flush with the camera plate. While this obviously helps to minimize accidental operation, some may find it that much more difficult to purposely engage them, particularly when wearing even the thinnest of gloves.
The Q.Menu button resides near the bottom of the rear plate, perhaps not the most convenient location for what we've long found to be a frequently used control point. All but the most dextrous of users will have to shift their hand from the shooting position to comfortably reach it. It would seem reasonable enough to switch its position with the Disp. button, as we'd guess that most users will access that button less frequently.
Minor quibbles aside, it's hard to find much fault with such an extensive set of external controls. What is perhaps most interesting is that the evolution of Panasonic's touchscreen interface, including a new Touch Tab feature, has made nearly all of the functionality of external controls available via the LCD screen. The GX1 provides an equivalent operational experience for those who prefer a touchscreen as well as those who would rather press external buttons.
Discuss in the forums
|Panasonic DMC-GX8KBODY LUMIX GX8 4K Interchangeable Lens Camera Body Black Bundle
|Panasonic DMC-GX8SBODY LUMIX GX8 4K Interchangeable Lens Camera Body Silver Bundle


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Dec 20, 2012 10:30 AM
Fact: you can never have too many cardigans. You should see how many we've got packed into our closets, and we're still going to be picking ourselves up this Red Open Knit Stud Embellished Cardigan ($49). If we run out of room, we'll just build a special cardigan-holding wardrobe out of old pallets.
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