text:
|Publication number
|Publication type
|Application number
|Publication date
|Apr 16, 1996
|Filing date
|Oct 4, 1994
|Priority date
|Dec 19, 1991
|Fee status
|Also published as
|Publication number
|Maurice A. Kildal, Frank A. Richardson, Claude E. Monsees
|Original Assignee
|Johnson & Johnson Clinical Diagnostics, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (15), Referenced by (16), Classifications (26), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a divisional of application Ser. No. 08/037,176, filed Mar. 26, 1993, now U.S. Pat. No. 5,384,947 which is a continuation of application Ser. No. 07/810,229, filed Dec. 19, 1991, now abandoned.
This invention relates to a stack of slide-like test elements used in a diagnostic analyzer, and particularly aspects allowing the stack to be so used, free of any cartridge.
In the field of dry slide diagnostic analysis, it has been most common, particularly in the large analyzers, to package the slide test elements in a cartridge. Such cartridges keep the essentially identical members of a particular lot of an assay together, and allow the analyzer to properly interface with the slide elements. These features are illustrated in, e.g., U.S. Pat. Nos. 4,187,077 and 4,190,420.
Notwithstanding the outstanding success of such packaging, as witnessed by the hundreds of thousands of cartridges that have been sold in the 80's by Eastman Kodak Co. under the trademark "Ektachem", there remains some drawbacks in such use of cartridges. That is, the cartridges are a sizable contribution to the expense of the slide elements, and further require a careful determination of when they are empty, as is explained in the aforesaid '420 patent. Still further, even after determining that they are empty, the empties have to be disposed of--a sizable problem as throughput is increased. Because of these drawbacks, there has been interest in packaging an assembly of slide elements without requiring the use of a cartridge. However, due to the fact that the readily apparent solutions lack a sturdy way of keeping together the identical, lot-specific members of the stack, sans cartridge, there has not been an acceptable way of eliminating the cartridge prior to this invention.
Yet another drawback of cartridge-supplied slide elements has been the manner in which coded information is supplied to identify the assay of the cartridge, e.g., by bar codes. Either the cartridges are printed directly, or printed labels have been used heretofore. Such labels require a separate printing operation and then a correct combining of the printed label with its associated cartridge. It would be more advantageous to inherently provide the coding, e.g., a bar code, simply by the act of assembling together the stack of slide elements.
We have designed an assembly of slide elements that solves the above-noted problems.
More specifically, the invention in one aspect provides an assembly of slide-like test elements suitable for insertion into a diagnostic analyzer, the assembly comprising a plurality of slide-like elements placed one on another to define a stack having at least one side face, each of the test elements comprising a heat-fusible plastic frame and at least one reagent within the frame capable of producing, in response to the presence of an analyte, a detectable signal; each of the frames of the stack being temporarily fused to the next adjacent frames.
In another aspect of the invention, there is provided a stack of slide-like elements assembled together, the stack comprising heat-fusible plastic frames of generally planar configuration, disposed in the stack one above another, the stack having at least one side face, means for temporarily holding the frames together at least a common side edge of the frames, and a bar-code extending along the at least one side face of the stack.
In still another aspect of the invention, there is provided a method of affixing together a group of completed slide-like test elements for use in an analyzer, comprising the steps of:
a) assembling together into a stack, one above the other, a plurality of slide-like test elements each of which comprises a heat-fusible plastic frame and at least one reagent effective to test a patient liquid in an analyzer, to form at least one stack side face,
b) temporarily heat-fusing the elements together as a stack by fusing at least a portion of at least one side edge of the frame of each element to the side edge of the frame of an adjacent element along the at least one side face of the stack, and
c) inserting the stack of temporarily fused test elements into an analyzer.
In yet another aspect of the invention, there is provided a method of encoding in colored and white bars a stack of articles each having at least two side edges, one of which is totally white and the other of which has a portion bearing an exposed colorant, the method comprising
a) assigning some of the elements of the stack the value of the colored part of a colored and white bar code, and
b) assembling in proper sequence the stack so that the assigned some elements have the colored side edge showing and the rest of the stack elements have the white edge showing, in the sequence of the colored and white code.
Still another aspect of the invention features a temporary stack of plastic articles individually releasable from the stack, and bearing bar coded information, the stack comprising
a plurality of individual plastic articles each comprising at least two exposable side edges, one of the edges having an exposed colorant in at least a portion of its surface and the other of the edges being substantially free of colorant,
the articles being temporarily fused to each other so that the one side edges bearing the exposed colorant are placed in the stack with the other, colorless side edges so as to inherently form the bar-coded information by the colored edges alternating with the colorless edges in the sequence of said coded information.
Accordingly, it is an advantageous feature of the invention that an assembly of slide elements is provided for storage and use in an analyzer as an entire stack, without necessitating the added complicating presence of a cartridge.
It is another advantageous feature of the invention that necessary codes can be provided simply by the manner in which the slide elements are assembled in such a stack, avoiding the need for printing and attaching a coded label.
Other advantageous features will become present upon reference to the following Detailed Description, when read in light of the attached drawings.
FIG. 1 is an isometric view of a slide useful in the process, and also of the stack of the invention, the stack being suggested in phantom;
FIG. 2 is an isometric view of the completed stack, as it is shipped and stored in an analyzer;
FIG. 3 is an isometric and slightly schematic, partially fragmented view of a storage and dispense station in an analyzer, using a stack in accordance with the invention;
FIG. 4 is a fragmentary isometric view of a stack showing the process by which the elements thereof are temporarily fused together;
FIG. 5 is a fragmentary elevational view in section illustrating an alternative interface between the storage and dispensing station of an analyzer, and the assembled stack of the invention;
FIG. 6 is an enlarged, fragmentary isometric view of the stack of FIG. 5; and
FIG. 7 is a view similar to that of FIG. 2, but illustrating a preferred mode of providing a coding of information on the stack.
The invention is described in connection with the certain preferred embodiments, in which the slide elements of the stack are primarily those heretofore described in the patent literature and available under the registered trademark "Ektachem" from Eastman Kodak Company. In addition, the invention is useful with any slide element comprising a frame of heat-fusible plastic of any kind, regardless of how it is otherwise constructed, or assembled, and regardless of whether it is conventional or not. That is, the invention is in the stack of slide elements useful in a diagnostic analyzer, and method of constructing and using such a stack, and not in the details or the assembly of the slide element construction per se. Still further, respecting the bar code portion of the invention, that portion is applicable to any plastic article that is bar coded, whether it is a slide element or not.
Thus, as shown in FIG. 1, slide-like test elements particularly useful in the invention can be selected from any of the, e.g., colorimetric slide test elements 10 sold by Eastman Kodak Co. under the "Ektachem" trademark. These comprise, as is conventional, a heat-fusible plastic frame of polystyrene, surrounding and holding within the frame a reaction member of one or more layers 30, containing one or more reagents to provide a detectable change indicative of the amount of analyte present, when patient sample is added, as is well-known. Likewise, the invention is useful if the test element 10 is instead an ion-selective electrode test element (not shown) that also has a heat-fusible plastic frame made from polystyrene. In such an element, the reagent that is used to produce a detectable change includes, e.g., an ionophore that is selective for the analyte of choice, and the detectable change is an electric signal registered by the electrode (not shown). Again, such test elements are well-known under the registered trademark "Ektachem".
In accordance with one aspect of the invention, slide element 10 and all the others 10' shown in phantom, FIG. 1, can be affixed together in a stack which is useful in an analyzer without the need for a cartridge. Each of the elements 10, 10' has opposite major surfaces 12, 14, and side edges 16, 18, 20, 24, there being four such side edges in the preferred rectangular configuration. They are stacked so that the generally planar slide elements 10, 10' have their major surfaces 12, 14 in contact with the corresponding major surfaces 12, 14 of the next adjacent slide element. Most preferably, the stack has the side edges positioned so as to be coplanar, thus forcing an axis of symmetry 28 of the stack, to be generally perpendicular to each slide element.
Optionally, at least one but less than all of the side edges 16-24, for example edge 16, is coated with an exposed colorant, preferably a black colorant, such as a black pigment coated onto the plastic. Such colorant can cover all of the side edge, as shown, or only a portion thereof. The remaining side edges are left colorless or white. Its use is discussed hereinafter. As used herein, "colorant" refers to a color other than white.
As noted above, such slide elements, when ready for use in an analyzer as shown, include in an interior portion thereof, at least one layer 30 containing a reagent that produces a signal in response to an analyte. For colorimetric slide elements as shown, the reagent produces a change in density. A depositing aperture 32 is present in surface 12 of element 10, 10' to allow liquid to be deposited, and a viewing aperture (not shown) is formed in opposite surface 14, generally aligned with aperture 32 but not necessarily of the same size.
In accordance with one aspect of the invention, the stack 8 of FIG. 1 is rendered usable in a diagnostic analyzer by temporarily fusing, FIG. 2, at least one of the common side edges of the elements 10, 10' in the stack, at a stripe 40 which necessarily extends the length of the stack to temporarily join all the elements together. As shown, stripe 40 occurs along each of side edges 18 of the slide elements, that is, each element 10, 10' has been oriented to align side edges 18 together, etc. to form a stack side face 38. Stripe 40 can occupy only a small portion of side edges 18, as shown, or a majority or all of that edge. Most preferably, it extends generally parallel to axis 28, but it will be readily obvious that it can be tilted at any angle, e.g., as shown in phantom, 40'. Only one such stripe is needed, but additional stripes can be used. Optionally, more than one side edge, e.g., side edges 20, can also be striped (not shown).
The striping phenomenon is more specifically described hereinafter. It is however a very slight fusion of the edges of the surface of the side edge so as to create no significant change in the geometry of the side edge. As used herein, "no significant change" means that when individual elements are shucked off the stack, it is difficult for the naked eye to detect any surface alteration where the stripe had been. Thus, the stripe, while holding the stack together temporarily, is not such a strong fusion that each slide element cannot be non-destructively sheared off the stack as described below. The fusion or striping process is that described in U.S. Pat. Nos. 4,662,974 and 4,811,861, to which attention is directed for further details.
Any plastic polymer is useful for the frames of the slide test elements (or whatever article is being stacked), provided it is heat-fusible to allow two test elements stacked together, to be temporarily heat-fused together at a side edge. Useful plastic polymers include thermoplastic polymers such as polyolefins and copolymers of olefins. Highly preferred are polystyrene, polyethylene, polypropylene, and the latter copolymerized with ethylene vinyl acetate.
As shown in FIGS. 2 and 3, "shucking" or shearing off of individual elements is achieved by applying a force 50 against one of the side edges of the element. Most preferably, it is applied to the side edge perpendicular to the side edge having the stripe, e.g., side edge 16, and in a direction generally perpendicular to axis 28. Because adhesion at stripe 40 is minimal, the shear force required is minimal, e.g., about 1 to 3 kg of force applied to a slide element side edge 24 having a surface area of about 15 mm2 for polyethylene elements. Polystyrene elements require a higher force.
FIG. 3, when stack 8 is placed into an analyzer, it is preferably done so without benefit of a cartridge (and hence without the disadvantages of a cartridge). A biasing means, e.g. a spring 60, is used to urge the stack to a slide element dispersing station 70, which comprises means for applying force 50 against the top-most element 10 in the stack, e.g. a pusher blade 72, and a removable holding plate 74 for holding down the stack. (Plate 74 is shown for clarity as not covering completely top element 10, but it can also completely cover it.) Plate 74 is removable to allow stack 8 to be inserted. Additionally, station 70 includes a side support 76 abutting side face 78 of the stack. In this embodiment, stripe 40 is shown as being parallel to force 50 being applied for dispensing, but it can also be opposite to force 50 as shown in FIG. 2.
Stripe 40 is preferably formed, as mentioned above, by the technique of the aforesaid '974 and '861 patents. More specifically, in one useful method as shown in FIG. 4, slide elements 10, 10' are moved through guideways 80 on a surface 82, the guideways being applied with pressure to hold the assembled stack together. Surface 82 can be horizontal, vertical or tilted. The side edges to be striped, e.g. edges 18, are forced upwardly as elements 10 and 10' are faced, arrow 84, to advance between guideways 80. As the stack 8 advances, an air gun 90 projects a jet 92 of very hot air onto side edges 18, and the fusion stripe 40 is formed. The temperature of this jet is adjusted, depending upon the plastic that is being used. For example, if the frames of elements 10, 10' are polyethylene or polystyrene, the temperature is about 200�-215� C. The presence of the jet can be varied, and a useful pressure is about 50 cm of water.
Any number of elements 10, 10' can be so fused together to form stack 8. This is an improvement over analyzers requiring the use of a cartridge, since a cartridge is limited in its capacity.
Optionally (not shown), a blank element can be used as the top-most and the bottom-most element in each stack, which blank element comprises a solid frame without any apertures and without a reaction member within the frame. Such blanks at the ends provide useful protection against light exposure and/or physical damage to the reaction members of the test elements.
It is not necessary that a removable holding plate be used to hold the stack in place for dispensing. Instead, FIGS. 5 and 6, other mechanisms can be used. Parts similar to those previously described bear the same reference numeral to which the distinguishing suffix "A" is appended. Thus, FIG. 5, stack 8A comprises individual slide elements 10A, 10'A temporarily fused together by stripe 40A to allow the stack to be used at a slide element dispensing station 70A without a cartridge as described heretofore. Pusher blade 72A shears off elements 10, 10' and a pusher such as a plunger 60A pushes the stack in the direction of arrow 100. However, unlike the previous embodiment, station 70A is completely open at 102, and plunger 60A is free to be moved away from stack 8A, arrow 104, without causing stack 8A to follow it. Instead, a pair of grippers 110, 112 is used to releasably hold the stack in place. Grippers 110 and 112 each comprise a moment arm 114, a gripping face 116 at one end of the arm, and a hinge pin 118 at the other end of arm 114. A spring such as a torsion spring (not shown), pivots arm 114 outwardly, arrows 120. Gripping face 116 is provided with a surface that specially mates with side edges 20A of stack 8A.
More specifically, FIG. 6, each edge 20A is preferably beveled at 130, to create a gripping lip 132 between the opposite surfaces 12A and 14A. Gripping face 116 is then serrated with grooves that line up with the mating lips 132 of elements 10A and 10'A.
Preferably, the uppermost surface of grippers 110 and 112 is beveled at 132 to provide a camming surface to allow faces 116 to be pushed apart merely by pushing a stack down through opening 102 between grippers 110 and 112.
It is conventional for a bar code to be associated with a stack of slide elements. The code reveals the assay and the lot number, for example. However, this has been done conventionally by imprinting in some way the cartridge surrounding the stack, with such a bar code. In the absence of the cartridge, the question arises as to how to associate the bar code with the stack.
In accordance with the invention, the code is formed on one side face of the stack, e.g., the face comprising side edges 16 of the stack of FIGS. 1 or 2 (edges 16 being hidden in FIG. 2). The code can be imprinted directly via ink jet or laser printing, or it can be printed on a removable label which is temporarily applied to the side face and then removed after the bar code is scanned.
In accordance with another aspect of the invention, the bar code can be inherently formed during the stack formation, as an integral part of the stack. Such an embodiment has the advantage that no additional step of ink jet printing or labeling is needed on the stack side face. It is this embodiment that utilizes the colorant in at least one, but not all, side edges, e.g. side edge 16 as described above. It will be readily appreciated that any combination of colored and white (or colorless) side edges in a stack of side edges will, if properly arranged, inherently produce a bar code, FIG. 7. Parts similar to those previously described bear the same reference numeral, to which the distinguishing suffix "B" is appended. Thus, stack 8B comprise elements 10B and 10'B, stacked up with an axis 28B and a temporary stripe 40B, with side edges 16B being blackened for at least part, and preferably all, of that surface. Remaining side edges, e.g. 18B, etc., are white or colorless, as previously described. By having two black side edges 16B adjacent to each other, adjacent to a single white edge 18B, adjacent to a single black edge 16B, etc., the result is a double black bar 202, a single white "blank" 204, and a single black bar 206, etc., of a total bar code 200. All that is needed to create this code is, to pre-arrange each element 10B, 10'B in the stack so as to face outwardly (towards arrow 200), either side edge 16B or side edge 18B, as needed for the code. The code in turn depends on, e.g., the assay type and lot number for that particular stack, which is information readily storable in computer memory of the machine used to stripe the stack, shown in FIG. 4. That is, such machine simply rotates each element about axis 28B until the proper side edge faces "outwardly", FIG. 7, before the striping process begins.
It will be readily appreciated that for this embodiment of the invention, the articles of the stack have a symmetry such that the stack looks the same, except for the color of the side edges, whether edge 16B or 18B faces outwardly against arrow 200. Rectangular or square major surfaces 12B and 14B are most preferred for such symmetry.
The stack 8B of plastic articles so produced has its bar code 200 inherently produced, to indicate, e.g., the type of slide elements present, e.g., those suitable for testing for blood urea nitrogen (BUN). For other kinds of plastic articles not used in diagnostic analyzers, the code can be used to indicate price, date of manufacture, or the like.
The invention disclosed herein may be practiced in the absence of any element which is not specifically disclosed herein.
The invention has been described in detail with particular reference to certain preferred embodiments thereof, but it will be understood that variations and modifications can be effected within the spirit and scope of the invention.
|Cited Patent
|Filing date
|Publication date
|Mar 23, 1972
|Apr 9, 1974
|Corning Glass Works
|Method of joining
|Jun 5, 1978
|Feb 5, 1980
|Eastman Kodak Company
|Container with article positioning element for dispensing reagent coated slides to an automated analyzer
|Jun 5, 1978
|Feb 26, 1980
|Eastman Kodak Company
|Container for dispensing articles to an automated analyzer
|Jul 16, 1980
|Nov 16, 1982
|U.S. Philips Corporation
|Packing for a stack of rectangular, plate-shaped parts
|Aug 10, 1981
|Mar 29, 1983
|Rca Corporation
|Method of CRT manufacture using machine readable coded markings
|Jul 16, 1981
|Apr 3, 1984
|American Hospital Supply Corporation
|Self-stacking reagent slide
|May 21, 1981
|Nov 13, 1984
|The Secretary Of State For Social Services In Her Britannic Majesty's Government Of The United Kingdom Of Great Gritain And Northern Ireland
|Support means
|Jun 13, 1985
|Nov 11, 1986
|Mobil Oil Corporation
|Fastening apparatus for twist ties
|Mar 29, 1985
|May 5, 1987
|Roberts John T
|Method of dispensing from a cartridge for thermoplastic articles
|Feb 26, 1988
|Feb 21, 1989
|Eastman Kodak Company
|Adaptors for use with various containers bearing bar code labeling
|Apr 29, 1987
|Mar 14, 1989
|Poly Pro, Inc.
|Homogeneously fusion bonded cartridges
|Mar 17, 1987
|Jul 25, 1989
|Humbert Bernard M M
|Blister pack for presentation of an article having opto-electronic information thereon
|Sep 19, 1990
|Jan 14, 1992
|Fuji Photo Film Co., Ltd.
|Analytical method and apparatus using chemical analytical slides
|Mar 26, 1993
|Jan 31, 1995
|Eastman Kodak Company
|Cartridge-free stacks of slide elements
|Title not available
|Citing Patent
|Filing date
|Publication date
|Feb 12, 1999
|May 31, 2005
|Berthold Gmbh & Co. Kg
|Method for labelling sample containers
|Jul 13, 2001
|Dec 25, 2007
|Ortho-Clinical Diagnostics, Inc.
|Tandem incubator for clinical analyzer
|Oct 29, 2003
|Mar 31, 2009
|Roche Diagnostics Operations, Inc.
|Test element analysis system
|Dec 2, 2004
|Sep 15, 2009
|Idexx Laboratories, Inc.
|Retaining clip for reagent test slides
|Dec 15, 2009
|Idexx Laboratories, Inc.
|Retaining clip for reagent test slides
|Jun 29, 2010
|Perkinelmer Singapore Pte. Ltd.
|Method for labeling sample containers
|Sep 11, 2009
|Nov 19, 2013
|Idexx Laboratories, Inc.
|Retaining clip for reagent test slides
|Jul 13, 2001
|Jan 23, 2003
|Jakubowicz Raymond Francis
|Tandem incubator for clinical analyzer
|Oct 29, 2003
|Jul 22, 2004
|Martin Frank
|Test element analysis system
|Dec 2, 2004
|Jun 23, 2005
|Rich Carl R.
|Retaining clip for reagent test slides
|Jan 21, 2005
|Sep 29, 2005
|Ronny Knepple
|Method for labeling sample containers
|Dec 2, 2004
|Oct 27, 2005
|Stanislaw Barski
|Retaining clip for reagent test slides
|Jun 22, 2006
|Nov 9, 2006
|Pneutools, Incorporated
|Method of forming a stacked assembly of roofing caps
|Jan 14, 2010
|Idexx Laboratories, Inc.
|Retaining clip for reagent test slides
|Jun 1, 1999
|Dec 8, 1999
|Ford Motor Company
|Automotive heat exchanger
|Feb 12, 1999
|Aug 19, 1999
|Perkin Elmer Bodenseewerk Zweigniederlassung Der Berthold Gmbh & Co.Kg
|Method for labelling sample containers
|U.S. Classification
|206/459.5, 206/456, 206/526
|International Classification
|Cooperative Classification
|European Classification
|Apr 28, 1995
Owner name: CLINICAL DIAGNOSTIC SYSTEMS, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:EASTMAN KODAK COMPANY;REEL/FRAME:007453/0224
Effective date: 19950118
|Nov 9, 1999
|Maintenance fee reminder mailed
|Apr 16, 2000
|Lapse for failure to pay maintenance fees
|Jun 27, 2000
|Expired due to failure to pay maintenance fee
Effective date: 20000416


text:
Political Strategy Notes
The Upshot's Nate Cohn presents compelling evidence from precinct and county data that House Majority Leader Eric Cantor was not defeated by a wave of crossover Democrats.
GOP message guru Frank Luntz has a NYT op-ed, "Why Polling Fails: Republicans Couldn't Predict Eric Cantor's Loss" noting "Even if every scientific approach is applied perfectly, 5 percent of all polls will end up outside the margin of error...a poll is a useful tool for gaining insight and information, but it is only one arrow in the quiver. Without qualitative insight -- talking with voters face to face to judge their mood, emotion, intensity and opinion -- polls can be inconsequential, and occasionally wrong."
In their introduction launching a series on the U.S. elections at The Guardian Paul Lewis and Dan Roberts argue "US midterm elections: Republicans could triumph - but it's not a sure thing," and note that top forecasters Nate Silver, Larry J. Sabato and teams from WaPo and the NYT "essentially agree on the big question about control of the Senate: it is too close to call."
In the first installment of the Guardian series, "Political certainties beginning to fade in black-and-white Georgia As the US gears up for crucial midterm elections," Paul Lewis reports from Georgia, where Republicans are swimming against a changing demographic tide," the author notes: "If Perdue, 64, a gaffe-prone former CEO of Dollar General, secures his party's nomination, Democrats will paint him as a Mitt Romney-style plutocrat with a shady corporate history. It is a characterisation they hope will contrast with Nunn's commitment to public service...If Kingston, 59, who has represented a congressional district incorporating the city of Savannah since 1993, wins the runoff, Nunn's team will seek to characterise him as a Washington insider. Nunn, on the other hand, will claim to be an outsider, untarnished by the political fray."
U.S. District Judge Peter C. Economus has reinstated early voting (three days in advance of elections) for all eligible voters in Ohio.
Crystal Shepeard's Care2 post "Single Women Will Make the Difference in the Midterm Elections" explains "...nearly a third of unmarried women are not registered to vote...unmarried women have had the largest increase in new eligible voters since the 2012 election with more than ten million new voters. Many of them are young and tend to not participate in large numbers in midterm elections. In 2012, if unmarried women voted in the same numbers as married women, the difference would have been an additional 6.5 million more votes cast.
NPR's Maria Liasson has explained "Unmarried women are the single most important demographic this year. But unlike other "it" demographics (remember soccer moms?), single women are not a constituency that's in play: They're extremely reliable Democratic supporters...Single women make up about 25 percent of the electorate, and they're growing fast as marriage rates decline. But while they are reliable supporters for the Democrats -- that is, when they vote -- they are not reliable voters: Between 2008 and 2010, the participation of unmarried women fell by about 20 points. And between 2012 and 2014, single women's participation is expected to drop off by about the same rate...So single women present Democrats with a turnout problem, not a persuasion problem." Liasson goes on to point out that the election of Terry McAuliffe as Governor of Virginia shows that it can be done, and NC is the best proving ground for the strategy ion 2014.
In another NPR post, "Easy On The Ears: GOP Ads Adapt To Reach Women Voters," Liasson shows that Republicans are running scared of single women and softening GOP ad messaging in hopes of neutralizing their strong Democratic tilt.
Oh, Hell yes.

subset: commoncrawl


text:
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|3807 101st Ave East 34219
ELLENTON/PARRISH SALES: FULL HOME OF FURNISHINGS FOR SALE: Sofa, loveseat, tv stand, kitchen table, two queen beds, single bed with trundle, contemporary barstools, custom made chaise lounges, kitchenware, ping pong, foos ball, air hockey. NO tools.More info Email a friend
|2909 42nd st west bradenton 34205
WEST BRADENTON SALES: Barn Find Cars. Auto Memorabilia, Household Furniture, Dishes, Books, Records, Tools. Fri thru Sun 9AM-5PM. 2909 42nd St W, Brdntn 34205. 952-261-3512 (9AM-5PM)More info Email a friend
NORTH & WEST BRADENTON SALES: YARD SALE Saturday 8am-1pm 8304 43rd Ave W., 34209 Lots of miscellaneous & some antiques.More info Email a friend
PALMETTO SALES: 2 FAMILY Sale, Sat 8-? 3419 100th Ct E, PalmettoMore info Email a friend
|616 Cortez Rd W 34207
WEST BRADENTON SALES: YARD SALE Tools, Furniture, Household, ArtMore info Email a friend
|7417 17th Ave NW 34209
NORTH & WEST BRADENTON SALES: Multi-family garage sale. Various items all in good condition. Woman's clothing size large tops, large dresses, size 8, 10 and 12 skirts and pants. Various household items and children's clothing. Girls size 10 clothes. Boys size 14. Misses size medium...More info Email a friend
|1907 41st St W 34205
WEST BRADENTON SALES: Housewares, crafts, floral, treadmill, furntitureMore info Email a friend
SOUTH MANATEE SALES: MOVING SALE Fri & Sat 9a-2p 1502 54th Ave Dr W (Off 16th Street) 34207 Furniture & misc.More info Email a friend
|5908 55th Dr. E. 34203
MOVING SALES: Neighborhood Yard Sale - Saturday, June 25th 8AM to 12 PM Furniture, carpets, household goods, clothing 5908 55th Dr. East, Bradenton 34203 River LandingsMore info Email a friend
|2221 14th ave west 34205
MOVING SALES: Huge moving sale, come and get it wile it last! House hold items, refrigerator, china cabinet, remote control orthopedic bed, furniture, work out equipment, tools, clothes and much more. We will start at 8am and go until everything is sold! Cheap, Cheap...More info Email a friend
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text:
How do I deal with my mother insisting on adding sugar to my 5 month old's diet?
So i am from the Caribbean where older people tend to be anxious to introduce solids and full family diet to babies. My mother takes care of my 5 month old and she insists on giving her EVERY thing she eats, including sugary foods. I try to get her to stop but she continues to do it behind my back, i do allow fruit and vegetable purees that i make my self. Can i get some suggestions on how to deal with this without being at odds with my mom?
Posted: 08/06/2013 by a BabyCenter Member
Mom Answers
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If your mom is deliberately ignoring your rules, there's no way around it; you're just going to have to "be at odds" with her until she is willing to follow your decisions.posted 08/07/2013 by a BabyCenter Member
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text:
•Johnny's Irish Pub at 1382 Culver Road will host the 5th annual Patriot Week Benefit for the USO on September 13. Mojo Monkeyz kicks things off, playing from 5 to 8 p.m.; and then the Shakin' Bones will take the stage. Even the Buffalo Jills will be there to support the troops! (585-244-0990)
•The second annual Kick Cancer's Ass fundraiser is scheduled for September 13 and 14 at Montage Music Hall, 50 Chestnut Street. Scheduled to perform on Friday are Rock-N-Roll Social Club, The Windshield Bugs, Michele Sesito, The Stonecats, Nuthin' Fancy, Galzu and Free The Python. On Saturday, Steel Kingdom, Final Decline, Aggressive Betty and Order of the Dragon will play. (585-413-1642)
•A benefit concert is scheduled on September 15 at the Diplomat Banquet Center, 1 Diplomat Way. Performing will be Dixson & Garrison, Code 5 and Hoodoo Daddies. Proceeds will benefit the Kiwanis West Central Chapter Foundation Account and the Jared Wright Special Needs Trust to help the financial burden of caring for Jared, a 14-year old with Duchenne Muscular Dystrophy. (585-647-1566)
•On Sunday, September 15, Ferris Godridge American Legion Post, located at 691 Trimmer Road in Spencerport, will host a benefit for Lion Hans Martens. Performing at this one will be Special FX and DJ Rob Linton. (585-544-2316)
Drop Us A Line:
•So, what's your latest? New releases? Special shows? New band members? We'd love to help get your information out there. Mail the details to us at our new location – 1255 University Avenue, Suite 270, Rochester NY 14607; or email to email@example.com.


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New video for Aussie producer Flume who plays Button Factory for the Movements launch party tonight.
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Is $$\int\frac{1+\sin x}{\cos x}dx$$ the same as the integral of $$\sec x+\tan x$$ (since $1/\cos x = \sec x$ and $\sin x/\cos x = \tan x$)?
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The alternate form you suggest is of course correct. But for integrating, we can also profitably work with the expression as given. Multiply "top" and "bottom" by $1-\sin x$. So we want $$\int \frac{\cos x\,dx}{1-\sin x}.$$ Now with or without the substitution $u=1-\sin x$, we arrive at $-\ln(1-\sin x)+C$.
Of course $$\frac{1+\sin x}{\cos x}=\frac{1}{\cos x}+\frac{\sin x}{\cos x}=\sec x+\tan x$$ Now observe that $$\int \frac{1+\sin x}{\cos x}dx=\int \frac{1}{\cos x}dx+\int\frac{\sin x}{\cos x}dx$$ For the first integral $$\int \frac{1}{\cos x}dx=\int \frac{\cos x}{1-\sin^2 x}dx$$ This and the second integral are straighforward


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A Michigan SUV crash on Friday took the life of four people and left five with injuries in this early morning collision between two vehicles. The morning started off most like any other morning with the passengers in both vehicles headed to work, but it took a tragic turn for these nine people. The SUV carrying six women collided with a pickup truck carrying three men, according to 14U News on Feb. 1.
The horrific scene of twisted metal across an icy and snowy road was one of many accidents from the latest bout of winter storms to roll across the country this week. According to Sheriff Dean Roeslerk, the road had some icy spots and the SUV could have hit one, causing the driver to lose control.
Four women died instantly upon impact in this accident. They were identified as Angelica Magana-Ceja (45), Erika Ceja (35), Teresa Alvarez (35), and Jessica Magana (23). Perla Magana, the 26-year-old driver of the SUV and another passenger Leticia Ceja, 39, were rushed to a hospital and reported in stable condition today.
The three men in the pickup truck, who are painters, were treated at the hospital for minor injuries. They are identified as Ross Sterk (35), Eric Werkema (31), Jose Hernandez (28).
The SUV was traveling towards Kent, where the women were going to work, when it slid into the pickup truck. Sheriff Roesler said:
"There are some slippery spots. The scene of the crash is icy but there's also been a lot of traffic that's been through that as well that may have created some of it."
It took police just minutes to respond to the accident in the early hours of Friday morning.


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Fans of "Revenge" know that Emily Thorne will do all that she can to find out what she needs to know. On the next episode, she will take her next step, and it is Pascal that will pay the price. On April 24, Spoiler TV shared a new sneak peek for the episode, "Revenge" episode 3x20 titled "Revolution." The clip features Emily Vancamp, Olivier Martinez, and Barry Sloane.
What happens during this short clip? Aiden will kidnap Pascal, and he brings the man to Emily. She uses a fake identity to pretend she is from Homeland Security, and she questions Pascal. She wants the truth behind the events of the plane. Pascal did play a major role in the events surrounding her father's framing. She wants to know everything. The clip ends before he reveals anything though. Previews for the episode do tease a possible death for Pascal, but fans will need to tune in to find out if that happens or not.
TV Line did share new spoilers for the remaining episodes of this season, and the battle between Victoria and Emily will see a new focus. Jack, Nolan, and Emily will also through a major change in their partnership as well. Everyone involved will do things to make sure they get their voice heard and their point across. Photos for the episode do tease some tense moments between Victoria and Emily.
Fans should expect some big things during the final three episodes of season three. Season four will start a new journey, and fans will Jack's mother reason next season as well. The finale of the third season will see Daniel in danger, Emily and Victoria doing things that will 'blow' fan's minds, and Aiden trying to get revenge for both him and Emily. It has already been teased that the finale will take the series down a new path next season, so it is one to watch. "Revenge" will continue to air on ABC on Sunday nights.
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Summary is an amateur girl. She has dirty blonde hair with nice tits and curvy ass. She has only shot with BangBros.
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This is the second installment of the most beautiful women in the world counted down from 100 to 1. What better way to peruse beautiful women all in one book.
Jim Toun Gordon has been traveling the world all of his life. In 2007 he initiated the Urban Camper group to chronicle his travels throughout his home state of Texas. The purpose of the group was to hone his skills as an organized traveler while learning the history that each town or area provides. The initial plan was to camp prior to exploring the area of his choice. Thus Jim has expanded his travels to include at least one major vacation per year. Jim Toun Gordon was born in Udonthani, Thailand, but grew up in Brazoria, Texas from the time he was 6 months until he was 17. After a stint attending Southwest Texas State University in San Marcos, Texas he moved to Branson, Missouri where he honed his photography skills. He currently resides in Houston, Texas where he works as a photographer.
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Liberty Rings True, Philadelphia 2015 Publicado 22 de noviembre de 2015
Beauty Is Only Skin Deep Publicado 22 de noviembre de 2015
Urban Camper Publicado 30 de julio de 2015
Beauty Is Only Skin Deep 2015 Publicado 07 de diciembre de 2014
Beauty Is Only Skin Deep 2014 Publicado 28 de diciembre de 2013
The Urban Camper Lone Star Bucket List Publicado 09 de octubre de 2013
The Summer Of Friends, Baseball And Presidents Publicado 04 de octubre de 2013
Cockeyed Publicado 04 de octubre de 2013


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Santiago General Cemetery
All but two Presidents of Chile can be found here – most notably Salvador Allende – along with artist Violet Vine and Los Jaivas musician Eduardo Alquinta. A more emotionally-charged memorial, however, is the Memorial del Detenido Desaparecido y del Ejecutado Político, built in 1994 for the victims of Pinochet´s dictatorship who mysteriously and tragically disappeared.
It´s not uncommon to see hundreds of scattered bouquets of flowers that have been placed by the graves here and there throughout the cemetery. Keep an eye out for telltale signs of earthquake damage, such as cracked stones and lopsided angles.


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Magnum presents strong uniform line at SICUR, Spain
Between the 25 and 28 February, the 19th edition of SICUR was held. SICUR is the large international fair of security in Spain which, organised by IFEMA, brought together in the Feria de Madrid exhibition halls, a comprehensive sectoral representation, by arranging a meeting of great dynamism and professional activity. A total of 1,300 participating companies with an innovative offer of products, equipment, services and solutions, and the attendance of 38,963 visitors from 74 countries, makes SICUR the platform par excellence once again where you can keep your finger on the pulse of the market and enter an informative forum on regulations, cutting-edge trends in protection and prevention. he exhibition brought together the offer of 1,300 companies and was visited by 38,963 professionals
The international presence came to 2,885 professionals from 74 countries
A strong interest in Magnum uniform products, occupational as well as safety footwear. Magnum supplies into various government organsiations and the Uniform Line is certfied to the latest EN ISO standards.
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| General Admission
Tickets $15 Online or $18 at the door
($.75 online handling fee applies)
Stuff to keep in mind…
1. No paper tickets are mailed. Your name will be added to the "Will Call" list.
2. Chaplin's is BYOB. There is a $4 per drinker corkage fee, for those who would like to bring beer or wine.
3. Doors open one hour before showtime.
4. Chaplin's does not allow audio or video recording during live performances.
Reserved seating in the main listening room is now sold out for this show. General Admission available


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Jesse Jackson came to Jacksonville on Wednesday, July 17th to protest against the Stand Your Ground Laws. The rally was held at Mt. Olive Church at 6 p.m. and there was standing room only at the event. The issues that was discussed during the rally was the criminal justice system and the Marissa Alexander case.
Jackson went to visit Alexander at the jailhouse. Alexander is an African American woman that was sentenced to 20 years in prison for firing a warning shot into the wall at her home in 2010 to end an violent argument with her abusive husband.
"In one case Mr. Zimmerman kills a young man and walks away, free to kill again," Jackson said. "And Marissa shot no one, hurt no one, and she's in jail for 20 years."
Jackson said the contrast in the Zimmerman and Alexander cases exposed injustices in the justice system. Alexander's case received little attention when she was convicted but that changed after the Trayvon Martin killing cast a new spotlight on Florida's self defense laws.


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When Thomason related that a severe storm had buried the entrance to the underground city of gold, Jack and Bill had become certain that the treasure hunters were just spinning some fine Southwestern yarn.
But all that certainty was put on hold because Thomason and White were still grinning from ear-to-ear, despite the apparent bad news.
Thomason belted out, "You've forgotten about the old boat landings on the Death Valley side of the Panamint Mountains! All we have to do is climb up the mountain to the openings where the galleries come out. Do you know the mountains along the west side of Death Valley?"
"I've been down there," said Bill.
Thomason and White figured that the galleries were around forty-five hundred or five thousand feet up from the bottom of Death Valley. Looking out from these ancient windows, they were able to see the green of the ranch below them and Furnace Creek Wash across the valley.
"We'll find those windows in the mountains, all right," said Thomason.
Bill asked, "You going down there now?"
"That's what we came here for," said Thomason.
Tired of the scientists and government officials trying to rob them, Thomason and White were now intent on getting rich, while at the same time, turn the hidden city into some sort of a tourist attraction for all to come and see.
Jack asked them what they wanted him and Bill to do.
"Nothing," said Thomason, "absolutely nothing. You've done a lot for us already. You've been mighty good to us. That's why we told you about this place. You can go down there yourselves, and you're welcome to all you can carry out. There' s plenty to go around. But please don't say anything about it. We don't want the news spread around until we're able to protect our property."
"Sure, " said Bill, "there'd be an awful rush in here if people was to find out about this place. We'll keep it quiet, won't we Jack?"
"Quieter than they've kept it themselves, " said Jack.
When day broke, the treasure hunters made their good-byes and promised to stop by on their way out to show Bill and Jack some treasure.
Ten days had passed before Bourke Lee returned to Emigrant canyon to see Jack and Bill. None of them had seen the treasure hunters since. After another week had passed with no word from the treasure hunters, Bourke and Bill decided to go down to the valley and take a look at the side of the mountains.
Using Bill's field glasses, they scanned the face of the Panamint Range across the valley to the west. They spent forty minutes between them looking for those galleries until their eyes had had enough.
"This is all foolishness," said Bill. "There's no windows in that mountain. I knew it before I come down here. See that big red streak across the mountains? That's an iron stain. Three hundred of the best prospectors in the world have climbed over that face of the mountain. They covered every foot of that range. Are you trying to tell me they wouldn't have found these windows or boat landings or whatever they are?"
"Underground city!" Bill said in disgust.
The men returned disappointed and perplexed as to why the broken-down guests would make up such a story. They told Thomason and the Whites they wanted nothing in return for their hospitality. So, if the guests had more to lose than gain by revealing their secret, then what would be the point if it wasn't true.
In less than a year, the secret found its way out and everyone in the Death Valley region knew about the story of the hidden city of gold. It was even being told as far away as San Francisco and Salt Lake City.
An expedition, headed by a Pacific Coast industry business man, set out to find the hidden underground city but to no avail.
Bill, still haunted by the possible existence of this underground city, convinced his neighbor Tom Wilson, the Paiute whose grandfather had been through the tunnel, to help him search for the tunnel. Their trip ended up uncovering a shaft in a spot that it shouldn't have been in but it didn't lead anywhere.
The following Spring, Bourke Lee and a partner, spent six weeks in the Panamint highlands searching as well but they too were unable to find anything.
Others kept coming, continually hiring Tom Wilson out to be their guide.
But by the time John Thorndike arrived to do some hidden city hunting, Tom Wilson's superstitions about approaching the sacred portals of the shaft, that probably led to an Indian hereafter, suddenly prevented him from being used as guide.
Or so he said. Undeterred, Thorndike set out to find the shaft himself.
Thorndike did indeed locate the infamous shaft but it only appeared to be an old abandoned mine shaft with an unknown history. Frustrated, John told Tom that the tunnel was just an Indian fairy tale and decided to return his camp in Wildrose.
Strangely enough, when Tom arrived back at camp, a multitude of vehicles and people were waiting for him. And even more interesting was the fact that Maxfield, one of Death Valley Scotty's men from the Death Valley Ranch, was sitting down awaiting his arrival as well.
Maxfield said, "Scotty's partner, Johnson, is up on Telescope Peak with the horses. Scotty's camped down the road. We been wondering where you were. Heard you were hunting this lost city."
Thorndike acknowledged he had searched for it but had decided to give up. Thorndike then made his way over to where Scotty was camped at. Oddly, this place just happened to be Scotty's favorite spot. Scotty had said that he was drawn to this spot because it had a nice breeze that blew through while the rest of the area sweltered.
"Scotty pushed his sombrero back on his head and snapped his bright shrewd eyes at John Thorndike. Scotty had to laugh at John and his looking for the golden Panamint caverns. Scotty pulled up his pants and his well-knit body shook with strong inward laughter, some of which escaped."
"Humph!" said Scotty. "So you didn't find it."
"No," said Thorndike. "We didn't find it."
"Humph!" said Scotty. "I can go right to it. Death Valley Scotty knows his country."
Bourke Lee's book, Death Valley Men, ends right there with the region's most intriguing character uttering a most telling statement.
The book appeared from the outset to be just a wonderfully written description of a land carved out by nature along with its colorful characters, based on the author's personal experience. Put in ink perhaps to both inspire and attract the blossoming automobile tourist to a place of unbelievable beauty in the 1930's.
But soon questions concerning one of the region's most famous people, Walter Scott, are asked as to why and how he built his castle out in the middle of an unforgiving desert.
The why can be chalked up to perhaps someone who loves the beauty and serenity of such an isolated region. People are eccentric so if something seems weird to you, it probably seems quite normal to them.
The how he did it is a bit more complicated.
Scotty always said he had a secret mine. That is immediately rejected because those who knew him said he was neither a prospector nor a miner. More of charming conman who had a knack for telling tales and emptying pockets. So when Scotty saddles up with Albert Johnson, the Chicago millionaire, it is assumed that is how Scotty got the money to build the castle.
What doesn't make sense, however, is that just two years earlier, Johnson discovered that Scotty was defrauding him and left the area. But Johnson suddenly returns, helps build the castle and becomes very close friends with Scotty.
Something big had to have happened during that two year period for Johnson to forgive so easily. And for millionaires to forgive easily, money has to be involved.
That "something big" is dropped as a bombshell extra-grande style in Lee's final chapter titled Old Gold: The existence of an ancient underground city of gold in Death Valley, estimated to be worth billions and billions of dollars.
And Scotty found it.


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Other racers had equally inventive ways of cutting weight at the track. "When I was working at David Pearson's shop," McReynolds says, "I was in the parts room one day and found an old helmet lying on the shelf. I thought, What in the world is this old thing doing back here? I picked that thing up and it must have weighed 70 pounds! It was filled with weight, and they would hang it in the car as it went through inspection. Then, all of a sudden, right before the race they would have a radio problem or something and have to get the backup helmet. Well, they went and got a helmet that weighed about 65 pounds less."
These tricks from racing's "good old days" make for great stories, but they also prove the point that NASCAR is tougher than ever on cheating. You don't hear about lead-filled helmets or other such outlandish things these days because they would never get through the tech line. NASCAR's tech officials have improved tremendously since then, and where teams could once get away with breaking the rules by a yard, today's racing teams can't get away with fractions of an inch.
Making It PublicMany of the people we spoke with for this article pointed out a major change in the way both the public and race teams view cheating. That's because of NASCAR's relatively recent policy of announcing which teams are caught cheating and exactly what they did. It's one thing if your indiscretions are kept behind closed doors; it's quite another when it's aired like dirty laundry for all the world to see.
Therefore, with NASCAR's incredible growth and popularity, a lot more people take notice when a team gets caught cheating. "One time [NASCAR] caught me infringing just a little bit with soft tires and a big motor," racing legend Richard Petty says of an infamous incident after a win in the 1983 Miller High Life 500 at Lowe's Motor Speedway. Petty's comments are comically understated; he was caught running softer left-side tires on the right side and with an engine that was 382 cubic inches-24 over the allowable limit. "At that time we were working with STP, and they loved it because it was in the newspaper and they were getting their name out. But that won't work with [current sponsor] Cheerios. They won't tolerate it."
When Petty was caught in 1983, racing news was so limited that anytime a sponsor found itself in the news it was at least considered publicity. But now, as race coverage is commonplace in major print and broadcast media, sponsors are understandably much pickier about how they are presented to race fans. With the money at stake, few are willing to be associated with cheaters-even if the method of cheating was something treated with a mere wink in years past. And teams, which are more dependent on sponsorship money than ever before, are listening to the wishes of corporate sponsors in ways they never listened to the rule makers.


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I setup tmux powerline, and installed all the corresponding fonts. The problem I am running into now is colors not appearing the same when acting as a background in the hardline.
I made sure to set tmux to use 256 color mode
tmux.conf: http://hastebin.com/durehunuge.conf
Any ideas on how to get the colors to match?


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for visitors
St. Mary's Hospital
5801 Bremo Road
Richmond, VA 23226
Map & directions
General visiting hours: 6:00 a.m. - 9:00 p.m.
Between 9:00 p.m. and 6:00 a.m., visitors may enter the hospital through the emergency room.
Intensive Care Unit (ICU) and Critical Care Unit (CCU):
10:00 a.m. - 2:00 p.m.
4:00 p.m. - 7:00 p.m.
8:00 p.m. - 9:30 pm
We encourage visitors not to bring children to critical-care areas of the hospital. Please do not bring plants or flowers to critical patients; these can pose a health risk.
Birthplace: 11:00 a.m. - 9:00 p.m.
Please do not bring children under age 12 unless the child is a sibling of the newborn.
Click here for information about the Evelyn D. Reinhart Guest House.
Send an e-mail to a patient at St. Mary's Hospital


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Review of Matlaw's stuffed scallops and stuffed clams. Ever wonder if the food tastes as good as the photo on the box? One of the best times to try it is when it's on sale or better yet when you fall upon a BOGO or buy one get one free deals. There was a special BOGO deal at a local Central Florida market for $3.99. Any shopper could purchase a choice of six large grill-ready New England style stuffed scallops or clams or the smaller size stuffed clams with 12 pieces. It seemed too good a deal not to buy it so this is a review of one six piece box of large size stuffed scallops and a six piece box of large-size stuffed clams.
The large scallops and clams box is listed as 9 ounces which probably include the shell. You can't tell the difference between the two probably because the main seafood ingredient is somewhere in the middle of the ingredients list with water and bread crumbs being the top two. It was tasty, for bread crumbs but that's about it.
The color and presentation for appetizers are nice, but don't expect much in tasting or finding the scallops or the clams, it's either seasoned with the water from the seafood of just the seasoning. The taste test included three pieces from each box, however, there was only one tiny piece of clam that was felt in one of four pieces, each shell was about an inch and a half round; a good size serving.
For the price it's worth the appearance of something good. The website says it has a mix of "golden breadcrumbs, spices, minced celery (that is noticeable) and green peppers with succulent bay scallops…" that's all true, and in that order it's lost in the mush of breadcrumbs. Should you try this? Sure, why not? But then again if you are craving the taste, texture and expectation of true scallops and clams, the answer would be no; save your $4 and go elsewhere.
If you're looking for a recipe for stuffed scallops or clams or crab or lobster you may want to click here and make it yourself and then you'll know how much seafood is in each piece.


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The institute can be traced back to a production plant for electric equipment established in Moscow in 1941. In 1944 NII-627 (Scientific Research Institute) was established on premises of the plant. In 1946 NII-627 was given engineering responsibility for electric functional equipment for the R-1, the Soviet copy of the V-2. They then developed further such equipment for later Korolev and Yangel missiles. In 1953 NII-627 was renamed the All-Union Scientific Research Institute for Electromechanics (VNIIEM).
On 30 October 1960 development of the Soviet Union's first weather satellite was begun by Yangel's bureau. VNIIEM had developed an innovative electromechanical satellite stabilization system and was a principle subcontractor. Overburdened with higher priority missile and military spacecraft work, Yangel agreed to transfer complete responsibility for the spacecraft to VNIIEM in 1962. VNIIEM thereafter began a sometimes not-too-successful forty year run of building the Soviet Union's meteorological and remote sensing satellites.


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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30414
Harder, Y; Amon, M; Schramm, R; Contaldo, C; Metzkow, E; Matzen, A; Rücker, M; Vollmar, B; Menger, M D (2009). Erythropoietin reduces necrosis in critically ischemic myocutaneous tissue by protecting nutritive perfusion in a dose-dependent manner. Surgery, 145(4):372-383.
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BACKGROUND: Erythropoietin (Epo), the primary regulator of erythropoiesis, has recently been shown to exert antiinflammatory and antiapoptotic properties in neuronal and myocardial tissue. We herein studied whether Epo pretreatment can reduce cell death and ischemic necrosis in a chronic in vivo model. METHODS: C57BL/6 mice were treated daily for 3 consecutive days with either 500 IU EPO/kg body weight (bw) (group Epo 500, n = 8) or 5000 IU EPO/kg bw (group Epo 5000, n = 8) administered intraperitoneally 24 hours before surgery. Thereafter, a random pattern myocutaneous flap subjected to acute persistent ischemia was elevated and fixed into a dorsal skinfold chamber. Flap elevation in animals receiving the water-soluble vitamin E analog Trolox (6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid) served as a nonspecific antiinflammatory agent control group (Tro); untreated control animals (Con) received saline only. Capillary perfusion, leukocyte-endothelial cell interaction, apoptotic cell death, and tissue necrosis were determined over a 10-day observation period using intravital multifluorescence microscopy. RESULTS: Epo 5000 (44 +/- 26 cm/cm(2)) but, more noticeably, Epo 500 (116 +/- 32 cm/cm(2)) improved capillary perfusion compared with the two control groups, particularly the Con group (9 +/- 7 cm/cm(2); P < .05). The ischemia-associated leukocytic inflammation was found drastically attenuated in both Epo-pretreatment groups. Epo 500 further decreased apoptotic cell death and was effective in significantly reducing tissue necrosis (16% +/- 4% vs Tro: 48% +/- 7% and Con: 52% +/- 4%; P < .001). No angiogenic blood vessel formation could be observed in either of the Epo groups. Of interest, Epo 5000-but not Epo 500-increased systemic hematocrit. CONCLUSION: Despite the lack of neovascularization, Epo pretreatment was capable of reducing ischemic tissue necrosis by protecting capillary perfusion, ie, nutrition of the tissue. Low-dose pretreatment was more effective, a result that was most likely due to the better perfusion conditions without an increase of the hematocrit values. Thus, low-dose Epo pretreatment might represent a promising strategy to protect critically perfused ischemic tissue.
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|04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
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|12 Feb 2010 08:10
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Yesterday we brewed our second batch of Positive Contact. Our Cider-Beer hybrid that has a bit of farro, cayenne, and cilantro as well. I brewed the first batch with Ben a few weeks ago and that one will go on tap at our reho pub on Monday. I cooked up the recipe with a friend in the music-biz. Jesse and Ben are doing this second batch.
Ben Pressin' (oops, it is sideways)
We did a bunch of tests and really dig the first batch but decided for the second one to bump the ratio of fermentables from organic fuji apples up even higher and we decided to add the whole dried cayenne peppers later in the process for less heat and more earthy aromatics. We are stoked for this beer and looking forward to feedback from folks who come to the pub on which batch is best liked. We don't do focus groups or market research. We just rely on the kindness of beer folk. We will also be taking a few kegs of this beer to the Extreme Beer Fest in Boston.


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It's no secret that politicians tend to be hypocrites and part of the do-as-I-say-not-as-I-do elite. A good example of this comes from a new report published by the Employment Policies Institute (EPI) that found that a very small number of lawmakers endorsing the Fair Minimum Wage Act pay their interns.
According to the report, only four percent out of the 210 legislators supporting a minimum wage hike from $7.25 to $10.10 per hour pay their interns. That means 96 percent of House and Senate representatives do not pay their interns a single dime. Thirty-five Senate offices pay their interns.
In fact, this even includes authors of the bill: California Democratic Congressman George Miller and Iowa Democratic Senator Tom Harkin. House Minority leader Nancy Pelosi, who has come out in strong support of the bill, doesn't pay her interns, which was duly noted by Jan Helfeld in an interview he conducted during the 1990s.
"To cavalierly call for a $10.10 minimum wage while the vast majority do not pay their interns, shows that they are talking out of both sides of their mouth and are not living up to the same standards they expect of others," said Michael Saltsman, EPI's research director, in an interview with the Daily Caller.
"If you created a situation where you all of sudden had to pay for interns, there would be fewer intern positions available. A lot of folks up in Congress don't seem to realize that the same dynamic applies in the private sector. If you raise the cost of hiring employees, there are going to be fewer opportunities available for workers."
The issue of raising the minimum wage has been talked about greatly since President Barack Obama got re-elected. During his presidential campaign, he called for increasing the minimum wage to $9, but has since confirmed that he supports efforts to raise it to around $10.
The Washington Post reports that the U.S. president might even consider using executive action to raise the minimum wage. This past summer, the president stated: "Whatever executive authority I have to help the middle class, I'll use it." This month, Obama added: "I've got a pen and I've got a phone."
Vermont Independent Senator Bernie Sanders told the news outlet that President Obama is taking the matter very seriously and is "weighing" the benefits and disadvantages behind such a move.
"I am very pleased that the president and members of his administration indicated they're giving very serious consideration to this proposal," Sanders said. "The president is weighing the pros and cons in terms of the impact on the overall debate."
There are numerous arguments and unintended consequences when it comes to raising the minimum wage, but here a few of them to consider:
- Businesses increase their qualification expectations
- It hurts the unskilled, the uneducated, immigrants and youth from attaining jobs
- Why stop at $10, $15 or $50? If minimum wage helps then increase it to $250
- Higher minimum wage leads to job losses, cutting hours and a lack of hiring efforts
- Companies increase prices to offset the costs of raising the minimum wage
- Corporations support higher minimum wages to hurt their smaller competitors
- Unions endorse minimum wages because they are in direct competition with the unskilled
Instead of talking about increasing minimum wages perhaps there should be a discussion on abolishing it, returning to sound money and reducing the size and scope of government. That, or politicians should put their money where their mouth is and start paying their interns hefty salaries.


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Christ's resurrected body was a prototype of the body that all believers in Christ will receive, according to Pastor Robert Jeffress, First Baptist Church of Dallas, in an article published today, Sunday, April 20 in the Christian Post. Jeffress further said, "The belief in the resurrection of Jesus Christ from the dead is essential to the entire Gospel message."
Jeffress, who is currently pastor of the 11,000 member Baptist church in Dallas, previously was pastor for several years of First Baptist Church of Wichita Falls, Texas.
Jeffress brought a message on that theme today during his Easter service in Dallas because, "Easter Sunday is a marvelous opportunity to share the Gospel with those who don't know Christ. I realize that, in our congregation, we'll have a high number of unbelievers there who are coming as guests or simply there because of the holiday. I use my Easter message for two purposes; No. 1 to reach unbelievers with the Gospel of Christ and give them an opportunity to respond to the Gospel; and secondly, to equip Christians with the answers that they can share with peple about why the Gospel is important and what the essence of the Gospel is."
Jeffress further told CP today that, "Romans 1:4 says that it is His resurrection from death that is proof that He is the son of God. Jesus received a brand new body, the Bible says, and John the apostle says that he touched Him and he handled Him in His resurrection form."
Jeffress preached his Easter message on the death and resurrection of Jesus Christ in a sermon titled, "Jesus: The Passion and the Promise."
He disclosed he was interviewed by Alan Colmes on his Fox News radio program earlier this week. Colmes asked him, "Which is more important to you? The death of Jesus or the resurrection of Jesus?"
The Southern Baptist preacher responded, "They are of equal importance."
Scriptures to which Jeffress referred in his Easter sermon today included 1 Corinthians 15: 3-4; John 10:17-18; Acts 2:23: 1 Peter 2:221, 23; Nahum 1:3; 1 John 2:2; Colossians 1:13-14 as well as several others.
He said it is in Colossians and Corinthians that Paul teaches that Christ's resurrected body was a prototype of the body that all believers will receive.
Pastor Bear Morton of Twin Falls, Idaho Bible Church agreed, saying, "John 11:25 tells us, 'I am the resurrection and the life; he who believes in me will live even if he dies."
Anyone interested in receiving free updates of future Western Religions articles may click on the subscribe link adjacent to this article.


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TC TO ALEXANDER CARLYLE ; 13 August 1857; DOI: 10.1215/lt-18570813-TC-AC-01; CL 33: 23-26
Chelsea, 13 Augt, 1857–
My dear Brother,—I had a pleasant and kind Letter from you not very long ago; awakening manifold affectionate remembrances, and echoes of old times and things, in my mind: I have ever since been thinking from time to time that I wd send an Answer "soon";—yet, such is the pressure of my affairs, and such my own hurried weak condition, no answer comes till now; and indeed, of late weeks, I have been looking forward to this as the real time for it,—namely, the day's holiday I was to give myself on finishing a certain Section of my sad Book; whh feat has now been brought about at last. The day before yesterday I got a very welcome good little Letter from Tom (thank him for me); but this wd have come on its own score, had there been no new reason.
Ever since I wrote last year from Scotsbrig,1 I have been working like a slave; day and night involved in confusions, of the most unmanageable nature;—the only limit, not to break myself down altogether, in which case there wd be no hope of the job. Never in my life had I a thing so difficult to do; and I am fallen old, and feckless in comparison; hope much dead in me, especially: not fit to handle such huge mountains of rubbish;—yet dreadfully unwilling to be beaten by them, too! Being withal in the most evident state of special ill-health, worse than even naturally belongs to me at this age, I decided on getting a Horse again;2 have had a Horse since November last; and go riding daily as the Sun; whh does (I sometimes think) begin to tell on me at last, or at least prevents me getting still worse:—and so I fight along; and hope fairly to finish this frightful job too; after which I contemplate taking a rest for the remainder of my life, or mainly "a rest." This is a fine brisk Horse I have got (now into my third thousand of miles, riding upon him "after health"): how often did I think of my poor true Alick who used to buy me horses, and do all things for me, in old days! The poor Cutlugs3 whh you bought for £2"10 at Mainhill4 (do you remember it?), I often think, almost like to cry, of that poor Snaffle;5 & would not give the memory of it for the price of the best Horse now alive! My dear Brother, I know that your affection for me lasts and has lasted, faithful to the end: you need not doubt that mine towards you is, was, and will be the like. That is a mournful but blessed possession for us both, wherever we be in this world.— But the best news of myself I must give too; namely that I am fairly printing that unspeakable New Book; 150 pages of it off my hands forevermore; and if I can hold out wisely I shall verily do it, and get rid of it, one day, in a not discreditable manner! For years back, I have had hardly any other wish left. About this time twelvemonth, if I can go on neither too fast nor too slow, I expect to be rid of Three Volumes;—there will remain then, after such pause as I like, other Two Volumes,6 and not the tenth part of the difficulty in them. Steady, therefore; "steady!" as the drill serjeants say.
My poor Jane took a cold last year, two or three weeks after returning home with me; and could not get out of it again,—ill and weak in a high degree, often confined to bed (never out of doors at all), dreadfully off for want of sleep especially,—all winter thro'. In my hurries this was (to her, still more than to myself perhaps) a great aggravation. Not till the end of May could she get out again; and still she continued far below par in strength,—and I fear, continues so in some sensible degree. There appeared to me to be nothing specifically wrong with her; merely the crisis or summing up of a long tract of sickly sleeplessness &c &c which was come to a head: perhaps she might be a thought better even, could she once gather strength again. Above a month ago, being pressingly invited by the old Misses Donaldson (whom perhaps you remember), she went to Haddington; thence over into Fife (to her cousin Walter of Liverpool, who is a clergyman there,—poor kind "Uncle John" of Liverpool is dead several years ago): she is, this very day I think, coming over to Edinburgh to her Aunts (Grace &c, who live there, in fine suburban air "Craigen Villa", and are grown very good old Dames, of a strongly religious turn); after a week with her Aunts she goes back to Haddington,—thence home to me; I shd fancy, about the beginning of Septr. She does not appear to have gained much in strength, poor little soul; but we hope she will find herself really profited (as has sometimes been my own case) on getting into her old place, and summing the whole up, as then happens. I used to liken myself to an old garron whose harness, collar &c, had worn it into "raws":7 going 300 miles off, you get into new harness; which likewise hurts you: but on resuming the old harness, the "raws" are found somewhat mended nevertheless!—
John has not been here, or away from Scotsbrig, since soon after Newyearsday last. He came up hither about that time; to dispose of some troublesome tho' occasionally profitable shares in a Ship,8 which had been bequeathed to him: this he successfully da very wise act), and soon after returned to Scotsbrig. There he seems not to be doing much,—selling off old bequeathed Libraries (at Chester9 this, by Letter sent from Scotsbrig); corresponding with or about his "four wards" (rather indifferent subjects than otherwise I shd judge), occasionally having some of them with him there, &c &c;—he does not speak of setting up a House of his own, tho' now abundantly wealthy for that; seems to keep much at home about Scotsbrig; and to be healthy and contented there. He is a placid sanguine creature; looking always at the "sunny side of his cloud" (as our dear old Mother used to say);—and has a much more satisfied life than some others of us.
Dumfriesshire and all places are what they call "prospering" at present: many circumstances perhaps (the California gold, I privately reckon, most of all)10 have given such an explosive impulse to "trade," all corners of this Country are testifying [to] it.11 To me it is by no means exclusively beautiful, this enormous effulgence of wealth, and with it of luxury and gaudery and folly, on the part not of the wise men of the community (for it is not they that the "wealth" mainly falls on):—it is on the contrary inexpressibly ugly to me when I reflect on it; and I perceive that the Devil is in it, he in fact and no Saint! However, that is the course at present; all things rising in price; all manner of gamblers getting "fortunes" &c &c: and by and by there will be a very burbly account to settle indeed!12 I often think, for myself and you, we are better not concerned in it: I just above the fear of poverty and nothing more; you ditto, with your own bit of the Earth's surface secured for a field of honest industry to your children and you. There are more secrets in Heaven's ways of doing "kindness" to men, than men are always aware of.— At The Gill, at Scotsbrig they are in health, I think; Jamie a very good farmer (I perceive) and respectable honest man; things going the right road, with more money-profit than formerly, at The Gill too. Of Jean at Dumfries, a sim[ilar]13 account is to be given:—"all well" was the word two days ago.
Poor old Graham at Burnswark continues bodily in excellent health his Sister extremely frail; but both of them, he especially, much sunk in mind from what they were. In Miss Graham, I thought, it was mostly depression and darkness from ill health: but with him, memory is quite gone for practical purposes,—and this too is about the sum of the matter, for his "intellect," by itself, seemed much the same as ever when I saw him last year. John goes up from time to time; but finds it a very sad monotony I think, and has never the least change to report.
Tom's Letter yesterday gave me a sad glimpse into that Emigrant Steamer that took fire in your River! I had read the thing in the Newspapers with a very miserable feeling, for it seemed to be mere neglect and want of sense: but I did not know there was anybody we were specially concerned in there. Poor Jenny & her Household may well think with a strange shock of that poor Annandale Sister & her Goodman:14 Horrible indeed!— Give my affectionate regards to Jenny the first opportunity you have: if I were once a little more my own master, she shall hear from me again. Also to your own Jane, "Jane the Second";15—I can never think of her except as of a little child good at reading; and she has got a long way out of that!—
There was an account from Tom (I think to the Dr in winter last) about an adventure in Maple Sugar with his Brother-in-law;16 whh I read with much interest. The two rugged sons of Nature reading Homer in the Bush, while their pans boiled, made an admirable picture to me,—full of health, and rugged honest life and worth. I once thot to have written to Tom specially a word under this Cover: but on the whole, it will not now do; and you can tell him all I specifically had to say. Two other Volumes are ready for him here (one comes generally monthly17); I think I shall wait till there is a third then off with them. There are to be about 15 in all.18 Also you can tell him, our Harvest here (all but the hay whh was average) is said to be excellent. Certainly there has not been so hot a year in my experience here. I am writing now (as I am often obliged to do) in the open air,—under an "Awning" in the speck of garden; whh I whh I19 find a very useful invention. May was mostly winter's self: but in june & since we almost defied the W. Indies now & then. Scotland is far cooler, I hear.— Adieu, dear Alick: blessings be on you & what belongs to you. A Letter when you can.
Your affecte Brother / T. Carlyle


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Apple's latest was unveiled and then sold out within hours online. Then freshly patent stung Samsung launches its "Doesn't Take A Genius" campaign to showcase its rocketing Galaxy S3 (while directly challenging Apple and the iPhone5). So Patrick's identified "Clash of The Titans" is at full tilt again and showcased in the latest iPhone5 Special Edition on PatrickTV…shot at the San Francisco Apple Launch event.
This PatrickTV episode gives you two bits of insight that may influence your future innovation and business directions:
1. The iPhone5: The Full Scoop by Innovation & Mobile Expert Patrick
- The Good News & The Bad News (even if so limited)
- The feature review across the iPhone5 and into other Apple products
2. The Bigger Story: The "Clash Of The Titans"
- The Core 4 Who Really Matter
- The Strategic Direction For Each
- The Implications: Consumer, Marketer, Innovator & Any Business Professional
The iPhone5 ships this week and the battle between the new device, Samsung Galaxy S3 and Google, Amazon.com is going "thermonuclear" (a Steve Jobs term used about Google) towards Holiday 2012. Check out this PatrickTV to get the full scoop.
image credit: Apple. All rights reserved.
Don't miss an article (4,700+) – Subscribe to our RSS feed or Innovation Excellence Weekly newsletter (sample).
Patrick Meyer is the Global Correspondent for Innovation Excellence, and an Innovation and Business 3.0 Expert, Author and Keynote Speaker. He is the founder of PatrickTV and The CEO Futurist – Delivering The Future Now.


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Orange Chicken
4 medium (1 1/4 pounds) skinless, boneless chicken breast halves
Kosher salt and pepper
1 tablespoon olive oil
2 medium leeks, cleaned and thinly sliced
2 oranges
1 tablespoon orange marmalade
1/2 cup chicken broth
3/4 teaspoon chopped fresh rosemary
Chopped fresh parsley
Place chicken breast halves between 2 sheets of plastic wrap; pound to 1/2 inch thick. Sprinkle both sides with salt and pepper.
In a 12-inch nonstick skillet, heat oil over medium-high heat until hot. Add breasts and cook 6 to 7 minutes or until browned on both sides and chicken loses its pink color throughout, turning over once. Transfer breasts to platter; tent with foil while making sauce.
Add leeks to skillet, cover and cook over medium-low heat 2 to 3 minutes or until softened. In the meantime, zest 1 orange and squeeze juice from it for 1/2 cup. Halve and thinly slice a second orange.
Add orange juice, marmalade, chicken broth and rosemary to leeks in skillet. Turn heat to medium-high and cook 3 minutes to reduce sauce slightly, stirring occasionally. Stir in reserved orange slices and zest. Taste and add salt and pepper if needed. Pour orange sauce over chicken breasts; sprinkle parsley on top and serve.
-- Adapted from www.goodhousekeeping.com


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May 19, 2000
ANN ARBOR, Mich. -- Following a disappointing 8-0 loss to DePaul in the first round, Michigan rebounded with a hard-fought 5-4 win over top-seed Stanford on Friday (May 19) in the NCAA Regional 8 Championship. Michigan scored five runs in the first three innings to break a 21-inning NCAA Regional scoreless drought and then held on as freshman pitcher Marissa Young retired the last 11 batters she faced en route to her 17th win of the season (17-3).
Michigan got on the board first with a run in the top half of the first on a Pam Kosanke RBI groundout. The run was set up by a one-out walk to centerfielder Melissa Taylor, who advanced to third on a double by Stephanie Volpe. Volpe advanced to third on Kosanke's groundout, but was stranded there after Young popped out to first to end the inning.
The Wolverines appeared ready to turn the game into a rout with four runs in the top of the third, spurred by three hits and aggressive baserunning. Michigan leadoff hitter Kelsey Kollen drew a one-out walk to start the rally and was pushed to second after Taylor punched a single through the hole between short and third. Volpe followed with her second double of the game, this one down the leftfield line, to score Kollen and put runners on second and third with one out. Kosanke then collected her second RBI of the game when she laid down a bunt single to score Taylor from third, prompting Stanford to make a pitching change and bring ace Dena Sorensen out of the bullpen.
Still with one out, Kosanke and Volpe executed a perfect double steal, with Volpe scoring on a close play at the plate thanks to a textbook slide. Following a walk to Young, Michigan kept the pressure on the Cardinal as Kosanke took off for third on a steal attempt and ended up scoring on a throwing error by Stanford's catcher. Sorensen retired the next two Wolverines to strand Young on second base, but the damage had been done and the Maize and Blue held a 5-0 lead.
However, Stanford would not go away and quickly answered with a four-run third of its own, paced by a three-run homer off the bat of Pac-10 Player of the Year Jessica Mendoza. A bunt single by Stanford leadoff hitter Ramona Shelburne and a line-drive single to left-center by Robin Walker, who was 3-4 for the game, set the stage for Mendoza's shot deep over the rightfield fence.
Following Mendoza's home run, Young plunked Cardinal cleanup hitter Sarah Beeson, putting her on first, with still nobody out. Following a forceout at second and one of Taylor's nine strikeouts on the game, Stanford third baseman Jenni Shideler drew a two-out walk to put runners on first and second. Cassi Brangham proceeded to bang a double into left-center to score Kellie Wiginton and cut Michigan's lead to one run at 5-4. With runners on second and third, Jaime Forman-Lau came off the bench to pinch hit for Stanford, but was sent down swinging by Young to end the inning.
Young used the momentum from that inning-ending strikeout to settle down as she allowed just one baserunner the remainder of the contest. Cardinal shortstop Walker collected a one-out single in the fourth and stole second, but was stranded there after Beeson lined out to first base. Young then proceeded to set down the Cardinal 1-2-3 in each of the final three innings. She logged four strikeouts, including one of Mendoza in the seventh, to secure the win.
Michigan will continue its tournament run with a contest tomorrow (Saturday, May 20) at 12:30 p.m. against a foe still to be determined, while Stanford ends its season with a 45-18 overall record.


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Explore the City of Monterey, California
Attractions and things to do in Monterey
Monterey, the first capital of California, is recognized for its mesmerizing coastal beauty and its rich storied past. Among the city's fascinating anecdotes are tales of the coming and going of well-known author John Steinbeck, who drew inspiration from the area for many of his classic novels. Monterey is home to a diverse selection of dining experiences, unique shops and must-see attractions. There are enough things to do on land and on water to keep you busy from dusk until dawn.
Top Attractions in Monterey
Discover the difference between a sea lion and a sea otter during a scuba-diving expedition. Take a peek into the city's past along The Path of History. Explore the Monterey Bay Coastal Recreational Trail, which stretches 18 miles from Pacific Grove to Castroville. Satisfy your craving for the finest seafood, and your curiousity about anything related to fishing, at The Fisherman's Wharf. Whatever you're looking for, Monterey offers an incredible amount of things to do that will win over even the most particular traveler.
Cannery Row
Cannery Row was once known as "Ocean View Avenue." In January 1958, the popular tourist destination was renamed in honor of John Steinbeck and his well-known novel inspired by Monterey during its sardine canning heydays. Today, "the Row" offers a variety of restaurants, art galleries, world-class attractions and fun activities for the entire family. To help plan your trip to Cannery Row, visit www.canneryrow.com.
- Golf
Our Courses
Pebble Beach Golf Links
Ranked #1 among America's 100 Greatest Public Courses by Golf Digest.
Spyglass Hill Golf Course
Rated one of the toughest courses in the world from the Championship tees.
The Links at Spanish Bay
A true Scottish-style links course and one of the most ecologically sensitive courses in the world.
Del Monte Golf Course
The oldest golf course in continuous operation west of the Mississippi.
Peter Hay Golf Course
The only 9-hole par-3 golf course open to the public on the Monterey Peninsula.
Golf Instruction & Services
- Golf Academy & Practice Facility
- Become a Better Golfer
- Caddie Services
- Club Program for Golf Pros
- Live Golf Cams in HD
We Are Honored
- Quotes from Pros, Writers & Guests
- Accommodations
- Packages
- Spa
- Dining
The Lodge at Pebble Beach
- Stillwater Bar & Grill
Contemporary Seafood Bar
- The Tap Room
Classic American Tavern
- The Bench
Wood-roasted Specialties
- Gallery Cafe
Home-style Meals
- The Terrace Lounge
Full Cocktail Bar
The Inn at Spanish Bay
- Pèppoli at Pebble Beach
Northern Italian Flavors
- Roy's at Pebble Beach
Hawaiian-fusion Cuisine
- Sticks
Fore Sports, Food & Fun
- Traps
Bar Menu
- The Lobby Lounge
Full Cocktail Bar & Bar Menu
Also at Pebble Beach
- The Beach Club Dining Room
Creative California Cuisine
- Spyglass Hill Grill
Casual Dining
- Del Monte Bar & Grill
Clubhouse Fare
- Pebble Beach Market
Gourmet Deli and Wine Shop
- Stave Wine Cellar
An Intimate Wine Lounge and Cellar
- Shop
Shopping at Pebble Beach Resorts
- The Shops at The Lodge at Pebble Beach
- The Shops at The Inn at Spanish Bay
- Events
- Meetings & Weddings
Event Facilities
The Lodge at Pebble Beach
Meeting facilities include nine principal rooms with occupancy of up to 400.
The Inn at Spanish Bay
Flexible meeting spaces include six rooms and a ballroom with occupancy of up to 800.
Casa Palmero
Setting exquisite standards for executive groups from 2 to 85 people.
- Activities
Fitness & Tennis Clubs
The Beach & Tennis Club
Located near The Lodge at Pebble Beach. Learn more about our premier private social and recreational club.
The Spanish Bay Club
Located near The Inn at Spanish Bay. Learn more about the fitness, tennis and spa facilities.
Explore the Monterey Peninsula
Visitor Guide
The Monterey Peninsula attracts year-round visitors from across the country and around the world.
Family Vacations at Pebble Beach
Pebble Beach Explorers
See why Pebble Beach is a true family destination for both the young and the young-at-heart!


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Foodie Tout, Inc. announced today that Ron Lawson, age 58, was appointed to the Company's Board of Directors for a two-year term. Mr. Lawson's appointment to the board brings a wealth of agricultural knowledge to the Sonoma based Food company accelerator.
Chairman of the Board, Karen Foley, commented, "Ron has enjoyed a distinguished business career in the global agricultural sector and his appointment further strengthens our functional expertise and experience on the Board. I am confident that he will continue to make significant contributions to our company."
Following fifteen years as Vice President and Resident Manager of Merrill Lynch Futures, Mr. Lawson, became Managing Director of Lawson/O'Neill Global Institutional Commodity Advisors. The firm produces research on global Commodity Markets for Banks, Hedge Funds, Commodity Companies and Large Speculative Traders.
As a Foodie Tout, Inc. Board Member, Mr. Lawson brings a wealth of diverse agricultural knowledge to the company. Aside from being the leading authority on Cotton production, Mr. Lawson owns and operates Field of Greens Egg Ranch in Sonoma. Currently supplying eggs to some of the best restaurants and grocery stores in the Northern California market, Mr. Lawson is developing a "free will" chicken habitat program for his birds.
"As an expert and advocate of all things "farm to table" Mr. Lawson's knowledge and expertise are an added value not only to the company, but to our clients who need agricultural advise, " Foley said, adding, "It is an honor to have him on our board."
About Foodie Tout, Inc. Foodie Tout is the consumate food industry advisory company located in the heart of the Epicurean epicenter of the United States, Sonoma, CA. The company fouses on bridging the divide between brick, mortar and the Internet pertaining to food related businesses. Foodie Tout incubates, accelerates, and elevates food related businesses.
From crowd funding to social media management and promotion, to creating new branding and marketing channels, Foodie Tout is the go to firm for food manufacturers, artisan purveyors, restaurateurs and producers of high end culinary products. In short, we are the foodie company.
For more information on Foodie Tout, Inc. and its family of Internet sites, foodiecowdfunding.com, foodiedaily.com, and foodi5star.com, please contact firstname.lastname@example.com,


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I mentioned meeting Paul Wrenn in a previous article.
I did get the opportunity to ask him for some training advice, and he recommended a routine. Here it is:
1. Take a weight you can do 5 sets of 3 repetitions with (this does not include your warmup sets).
2. Build up to 5 sets of 5 repetitions with said weight.
3. Once you can successfuly do 5×5, ad 10-20 lbs and go back to 5×3 (five sets, three repetitions).
4. Work your way up to 5×5 again, and repeat.
So the first week you'll do 5×3. The next week you'll try to ad some repetitions. You may not do the same number of reps every set–you may get 3-4 reps per set instead of just 3.
But you keep using the same weight until you can successfully do 5×5, then ad weight and go back to 5×3. This is kind of a variation of a 5×5 workout.
I'm using this program now, and I really love it. It's simple but effective, and the incremental strength gains keep me motivated.
After I've done these five sets on bench or squat (depending on what bodyparts I'm working that session), I'll follow up with some lighter weight and higher rep exercises.
So my squat day looks something like this:
Squat 5×3
Romanian Deadlift 4×7 (4 sets, 7 repetitions)
Calf Work (calf raises, seated calf raise, etc).
This is usually about all I can handle for one workout. Squats take a lot out of me, and I'm lifting in a tropical climate with no air conditioning.
Note: I'd highly recommend Minimalist Training if you want to find some simple but brutally effective routines.


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While you are rushing around and enjoying the summer sunshine, take a break and prepare this heady, soul-satisfying pork roast. Known to us from the ad world as "the other white meat," a pork loin roast is lean and delicious on it's own, but even better spiced with a dry rub full of black pepper, garlic, rosemary and smoked paprika.
The double flavor-whammy in this recipe is that you are studding the roast with fresh garlic and rosemary before coating it with the dry spices. The inside herbs echo the flavor of the rub so they will be infused through the whole roast. The rub will caramelize on the outside and form a crust and the garlic and rosemary will get soft and scent the juicy meat. Besides, the slices look extra cool with little bits of rosemary and garlic buried into the meat. I love this pork roast served with Sweet Potato Chipolte Puree for dinner but make enough for leftovers, it makes a killer Cuban Sandwich the next day!
Rosemary and Garlic Rubbed and Studded Pork Roast
Grilling Method: Indirect/Medium Heat
1 tablespoon black peppercorns
1 tablespoon granulated garlic
2 tablespoons dried rosemary
2 tablespoons kosher salt
2 tablespoons sweet paprika
2 tablespoons smoked paprika
1 3-4 pound pork loin roast
1 small head garlic, peeled and cut into slivers
6-8 sprigs fresh rosemary, divided and soaked in water
Olive oil
Combine first five ingredients and grind in a spice grinder or mortar; set aside. Using a paring knife, cut a series of slits at least 2 inches apart into the roast. Insert garlic into half the holes and part of a sprig rosemary into the others. Coat the roast with a thin coating of olive oil and sprinkle generously with the spice rub. Place the roast (fat side up) in center of cooking grate on a bed of the remaining rosemary. Grill for one hour or until an instant-read meat thermometer reaches 155°F. Remove pork from roasting pan. Let meat rest for 10 minutes. Cut pork into thin slices and serve with Mashed Sweet Potatoes.
Serves 6-8
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