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Hemolytic uremic syndrome (HUS) is a condition that results from the abnormal premature destruction of red blood cells. Once this process begins, the damaged red blood cells start to clog the filtering system in the kidneys, which may eventually cause the life-threatening kidney failure associated with hemolytic uremic syndrome.
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Canadian Art Workshop - 9/25/13 - Noon in Ostermayer Lab 309
The Canadian Art Workshop will be presented by Mary Collins who earned a BFA from Carnegie Mellon University, where she studied under Sam Gilliam. She has taught art at the Carnegie Museum of Art, the Pittsburgh Center for the Arts, and the YMCA of Greater Pittsburgh. She has attended several prestigious art residencies, some of which were at the Yaddo Art Workshop in Hudson Valley, New York and the Triangle Art Workshop in Hudson Valley , New York.

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La Monnaie ¦ MM Extra ¦ Late Night at the Opera ¦ Intro
Late Night at the Opera
PARTY in the Opera!
Your wish is our command. While writing his new opera Au monde, Philippe Boesmans took inspiration from a wide range of music styles. That's why we have invited the electro trio The Subs to the final showing of Au monde to talk about the world creation in the framework of A Night at the Opera. Afterwards, Catclub dj's Lady Jane and Fais Le Beau will whip up some hot rhythms and great beats. La Monnaie's 2014-2015 season centres around the seven deadly sins. High time to discover yours and to make opera your own eighth deadly sin!
Don't miss some great promotion opportunities at that evening:
In the 90s, Lady Jane performed at the well-known Food parties in her hometown of Leuven alongside big names like Kenny Hawkes, Stacey Pullen and Derrick May. It wasn't long before she was whisked away to play on the international circuit in cities like Amsterdam, London, Berlin and Paris along with artists like Kim Ann Foxmann, Nicholas Jaar, Chloe, Planningtorock and Mano Le Though. While her musical preference might have evolved since then, her style still remains unique: melodious, sensual and soulful. Nowadays Lady Jane is the woman behind the famous Catclub parties that are closely linked with the art and fashion world and are always held at special locations in Brussels, for instance in empty art deco buildings and derelict post office sorting centres.
>> https://soundcloud.com/ladyjane
© Lisa Lapierre


text: Hope and A Prayer a.m. Topical Vitamin C Powder, a morning treatment, was originally formulated for the medical market for the treatment of all skin types. It is the first and only 99.8% potency, guaranteed stable, Vitamin C product that can be used alone or mixed with any of your favorite products to instantly convert them into a state-of-the-art Vitamin C formula. Science has demonstrated that the daily application of topical Vitamin C will retard and possibly reverse the aging process by neutralizing the corrosive effects of free radical damage. This product contains 0.25 oz of topical Vitamin C powder.Department: CosmeticsStyle: 500018A


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Best known for its unparalleled shopping, Paramus is also within easy driving distance of New York City, so our guests will never experience a dull moment! The 100% nonsmoking Holiday Inn Express® Paramus hotel also features comfortable, practical amenities, so you can enjoy your stay in Paramus, NJ.
Our hotel's business travelers can always take advantage of the modern business center, which features print and copy services, as
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Our hotel's business travelers can always take advantage of the modern business center, which features print and copy services, as well as computer access. We provide free high-speed, wireless Internet access throughout the hotel, as well as complimentary, wireless remote printing. If you're looking for hotels in Paramus, NJ near area businesses, you'll be glad to know that we are near IBM, as well as Equifax Holy Name Hospital and Englewood Hospital and Medical Center.
While in Paramus, you can easily visit the Westfield Garden State Plaza Mall, Shops at Riverside or Secaucus Outlets. Families enjoy catching a game at Yankee Stadium or visiting the picturesque Bear Mountain State Park. If you prefer to stay indoors, the Izod Center provides awesome entertainment. New York City is also within driving distance of Paramus, NJ.
Our hotel provides free Wi-Fi access throughout our hotel's accommodations. While in Paramus, NJ, start your day with a workout in the fitness center and enjoy the free, hot Express Start Breakfast Bar.


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- Location:
- Dearborn Heights, MI
- Party Albums:
- 1
Vintage Circus Party (14 photos)
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In a house filled (to the brim) with fancy toys that light up, talk, play music, and make you breakfast… my little Essa's favorite toy in the whole world is his old school Jack in the Box. His second favorite thing to play with is balloons…big, small, inflated, deflated, filled with water, he looooooves balloons. When it came time to plan his 2nd birthday party, a Big Top Circus theme was the first thing that came to mind!
I had so much fun planning this party but it was definitely A LOT of work. My husband and I actually designed and built a tabletop canopy structure out of like wood..and nails…and paint… it was really cool! Neither of us really have any experience in this sort of thing, but it was a really fun weekend project. We seriously didn't think it would come out half way decent but when it was done, we were thrilled with the results!!
For lunch, we had circus themed food including hot dogs, corn on the cob, nachos & cheese, french fries and soft pretzels. I put out plastic nacho trays, paper hot dog trays, and paper cups to serve the food so that the kids could run around and play while they ate.


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Miami Dolphins: Now, comes the hard part
The Dolphins can now officially join the party.
Welcome to the world of the Indianapolis Colts, Jacksonville Jaguars, Washington Redskins and Kansas City Chiefs. There was always a tiny, tiny, tiny, tiny (think of this scene from Dumb and Dumber) glimmer of hope the Dolphins could actually run the table and perhaps grab a postseason berth. Not many outside the locker room thought it could actually happen, but the players felt anything was possible.
A sobering loss to the Dallas Cowboys eliminated any chance of that happening.
Now, the Dolphins step into the realm of playing football without a purpose. Let me rephrase that. The Dolphins are officially "spoilers." There is no carrot dangling at the end of the string, other than the dislike of losing. Being out of the playoff picture with five games remaining is the equivalent to a baseball team out of the pennant race by June.
What to do now?
The hardest part is living with the fact that it didn't have to be this way. Thursday's loss dropped to Dolphins to 0-4 in games decided by three points or less.
So close, yet so far away.
If the Dolphins just go .500 during those games, the outlook for the remainder of the season is completely different. At 5-6, there's still a chance for the playoffs. Instead, next season is the primary focus. Now, the remainder of the season is just a formality.
They reached this point because of an inept red-zone offense against the Cowboys. Five trips inside the 20 (counting the time they made the 21-yard line and Shayne Graham missed a 47-yard field goal) should never produce just 12 points. They left too many points on the field.
"When we get in the red zone, we have to score touchdowns instead of field goals," tackle Jake Long said. "We were shooting ourselves in the foot."
Actually, it was more like a shot to the head. There are no twitching body parts on this season.
The fun ride the Dolphins were on the past three weeks is a thing of the past. Reality of a disappointing season is about to set in.
In some ways, 0-7 was probably more enjoyable than 3-8. At least then the Dolphins could think about making that magical run the final nine games.
That's no longer the case.


text: A pampering new sensation for dry skin.Luxurious creme foams into a moisture-rich lather to gently clean, calm and soften skin. Envelops you with a sense of total satisfaction. The Soft Clean collection provides gentle yet effective cleansing for dry skin. These innovative formulas help preserve skin's moisture barrier, as they add hydration and conditioners. A soothing botanical blend calms and softens. Dry skin has never felt so comfortable after cleansing.SOOTHING EXTRACTS:Passion Flower, EdelweissDepartment: CosmeticsStyle: 1Y1J-01


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Science, Technology, Engineering, and Mathematics Talent Expansion Program (STEP) Active Awards
This page shows the geographical distribution of active awards for SES. You can also
view lists of awards made by SES.
Click on a name in the table below to view active
awards in that state, territory or country.
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Since its inception, Ring of Honor has prided itself on presenting the absolute best professional wrestling on the planet with the top athletes not just from the United States but from around the world. In that endeavor, we have been graced with the presence of numerous wrestlers from the world of Japanese Puroresu; from young up & comers to the legends of the squared circle, ROH has been home to them all over the years. Be it Jushin "Thunder" Liger & The Great Muta or Go Shikozaki & Dragon Kid, they have all competed here and enriched the great history of ROH.
This 2-Disc collection brings to you a taste of the tremendous Japanese competitors that have stepped in between our ropes. Featuring behemoths like Takeshi Morishima, Junior Heavyweight stars like Kota Ibushi, Joshi grapplers like Hiroyo Matsumoto & Ayumi Kurihara, and legends like Kenta Kobashi & Mitsuharu Misawa, this 19 match collection is a tribute to all of the Puroresu competitors that have passed through Ring of Honor and the influence they have had. These men and women are truly Japan's Finest...
Disc 1
1. The Amazing Red vs. Ikuto Hidaka...Glory By Honor 10/2/02
2. The Great Muta & Arashi vs. Christopher Daniels & Dan Maff… Final Battle 2003 12/27/03
3. Kenta Kobashi & Homicide vs. Samoa Joe & Low Ki…Unforgettable 10/205
4. AJ Styles & Matt Sydal vs. Dragon Kid & Genki Horiguchi… Dragon Gate Challenge 3/30/06
5. Do Fixer (Dragon Kid, Genki Horiguchi, & Ryo Saito) vs. Blood Generation (CIMA, Naruki Doi, & Masato Yoshino)…Supercard of Honor 3/31/06
6. Colt Cabana vs. Kikutaro…Ring of Homicide 5/13/06
7. Christopher Daniels & Matt Sydal vs. CIMA & Shingo (World Tag Team Title Match)…International Challenge 12/22/06
8. CIMA, Susumu Yokosuka, Dragon Kid & Ryo Saito defeated Austin Aries, Delirious, Claudio Castagnoli & Rocky Romero…All Star Extravaganza III 3/30/07
9. CIMA, Susumu Yokosuka & Shingo defeated Dragon Kid, Ryo Saito & Masaaki Mochizuki… Supercard of Honor II 3/31/07
10. Takeshi Morishima vs. Shingo (ROH World Title Match)…Good Times, Great Memories 4/28/07
Disc 2
11. Naomichi Marufuji & Takeshi Morishima vs. Mitsuharu Misawa & KENTA…Glory By Honor VI Night 1 11/2/07
12. BxB Hulk & Shingo vs. Kevin Steen & El Generico…Supercard of Honor III 3/29/08
13. Muscle Outlaws (Naruki Doi, Masato Yoshino & Genki Horiguchi) vs. Typhoon (CIMA, Dragon Kid, & Ryo Saito)…Supercard of Honor III 3/29/08
14. Jay & Mark Briscoe vs. Austin Aries & Kota Ibushi…Tag Wars 2008 4/18/08
15, Team NOAH (Takeshi Morishima, Naomichi Marufuji, & Go Shiozaki) vs. The No Remorse Corps (Roderick Strong, Davey Richards, & Rocky Romero)…Southern Navigation 5/9/08
16. Kensuke Sasaki & Katsuhiko Nakajima vs. Brent Albright & Roderick Strong…All Star Extravaganza IV 12/26/08
17. Jushin Liger vs. Austin Aries (Non Title Match)...SoCal Showdown 1/29/10
18. Hiroyo Matsumoto & Ayumi Kurihara vs. Sara Del Rey and Serena Deeb...Honor Takes Center Stage Chapter 1 4/1/11
19. Hiroyo Matsumoto & Ayumi Kurihara vs. Daizee Haze & Tomoka Nakagawa...Honor Takes Center Stage Chapter 2 4/2/11


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20 April 2013
By Chris Bowers
Photo: Ray GiubiloRoberta Vinci (ITA)
PALERMO, ITALY: After two years of being blue and red, the Fed Cup by BNP Paribas may be going blue and white after Italy took a 2-0 lead over Czech Republic on the opening day of the eagerly awaited clash between the competition's champions of the past four years.
On a clay court that proved painfully slow for the Czechs despite the match being played mostly in bright Mediterranean sunshine, Italy showed its greater claycourt prowess with wins for Sara Errani and Roberta Vinci. While Errani's 64 62 win over Lucie Safarova is no surprise given that Errani is ranked No. 7 and Safarova No. 25, Vinci has now beaten Kvitova twice in six days on clay following her win in the final of the Katowice tournament in Poland last Sunday.
Vinci beat Kvitova 64 61 – very similar in score to the 76 61 with which she beat her on Sunday – in a match notable for its breaks of serve. There were nine in the first set, Vinci's service hold in the seventh game playing the role a break normally does. And Kvitova didn't hold serve once in the match, her five games coming exclusively from breaks.
But it was also a match rich in varied tennis, a real connoisseur's contest. Vinci is known for her slice, but hers was an all-court performance.
She made particular use of the drop shot, to the point where even when Kvitova ran the shorter balls down, Vinci was usually there to put the next shot away. Her infectious enthusiasm also worked the crowd to perfection, to the point where it was almost a carnival atmosphere by the time she won in 93 minutes.
As the match wore on, Vinci got more and more into Kvitova's head. While the slight Italian hit five aces, her fifth on match point, the big-hitting Czech threw in eight double faults, many of them at crucial moments. Kvitova was well and truly outpsyched, although she hinted afterwards that she was not 'physically ready' for this match.
Earlier Errani had been the vastly more solid player against a nervous Safarova. The Czech was ballooning most of her volleys over the baseline during the warm-up, and when play started for real, it didn't get much better. Aware that Errani would play like a brick wall, Safarova tried to make things happen – her strategy was to push Errani back with heavy topspin and then flatten out her crosscourt backhand. When it worked it looked very good, but the total of 37 unforced errors testifies how often it didn't work.
The first five games went against serve, but Errani was always ahead, and it was interesting that the first service hold came as some heavy rain drops began to fall. Fortunately they only lasted a few minutes, but by then Errani was into her stride. In her first match on clay she was making very few mistakes, which put the onus on Safarova to go for more winners. And the more she went for, the more errors she made.
In retrospect, the match – and who knows, possibly the whole weekend – was decided in that first set. Once Errani had won it on her fourth set point, she took command of the second set, and the more Safarova pressed, the more the errors flowed from her racket.
All is not lost for the Czechs. If Kvitova can beat Errani in the first reverse singles – and it is seventh against eighth in the rankings, so a real 50:50 – the momentum could swing the Czechs' way.
"I hope I can cancel this match in my mind and have a free mind for tomorrow," Kvitova said on Saturday. "I'm still getting better, and it's obviously tough to be 100% ready to play these girls on clay but we'll see."
Italy's captain Corrado Barrazzutti said there was 'no way' he would replace Vinci from the second singles to keep her fresh for the doubles.
And with the 30-year-old Italian playing some of the best tennis of her life and up to 12th in the rankings, it seems a perfectly logical decision.
Follow this tie as it happens: Live scores or Watch Live
Corrado Barazzutti (ITA) - 20/04/2013
Sara Errani (ITA) - 20/04/2013
Roberta Vinci (ITA) - 20/04/2013
Captain Petr Pala (CZE) - 20/4/13
Lucie Safarova - 20/04/2013
Petra Kvitova (CZE) - 20/4/13
19 Apr 2013
Sara Errani leads Italy out on day one against Czech Republic and will be looking to avenge defeat at the same stage last year
Czech Republic
20 Apr 2013 - 21 Apr 2013
View details
Czech Republic
Sara ERRANI (ITA)
Petra KVITOVA (CZE)
Roberta VINCI (ITA)
Klara KOUKALOVA (CZE)
Francesca SCHIAVONE (ITA)
Lucie SAFAROVA (CZE)
Flavia PENNETTA (ITA)
Lucie HRADECKA (CZE)
Circolo del Tennis Palermo, Palermo, Italy
Full details
Review the 2017 Fed Cup by BNP Paribas draw that took place in
Czech Republic will host Spain and USA will welcome Germany in
Vote for Hsu Ching-Wen (TPE), Angelique Kerber (GER), Garbine
Belgium's Yanina Wickmayer, who won two rubbers away in Serbia
The draw for 2017 Fed Cup by BNP Paribas will be held at the
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Funda��o Brasileira para o Desenvolvimento Sustent�vel
- Date submitted: 1 Nov 2011
- Stakeholder type: Major Group
- Name: Funda��o Brasileira para o Desenvolvimento Sustent�vel
- Submission Document: Download
Full SubmissionGuidelines for a Green Economy
Submission to the United Nations Conference on Sustainable Development
Rio de Janeiro, 4-6 June 2012
The FBDS is a nonprofit organization, founded in 1992 by 24 major business groups whose prime objective is to promote sustainable development. FBDS��s mission is to spread best practices in sustainability and environmental management through knowledge generation, contributions to public policy formulation, and implementation of consulting projects, in order to influence key stakeholders.
In 2011, the FBDS has led a nationwide effort in conjunction with major Brazilian corporations with the purpose of detect barriers and set up guidelines for the transition to a green economy1, based on the report Towards a Green Economy (UNEP). The process involved the academy, corporations, and discussions with major stakeholders and produced a set of recommendations to government and corporations. Those relevant to the Rio+20 context were selected and are now being submitted to the UNCSD2012 to be taken into account for the ��zero draft�� document.
The Conference should encourage countries to adopt the following guidelines in the energy, water resources, transport, solid waste, agriculture, forests, and finance areas when developing their domestic policies:
- To quantify GHG emissions from fossil fuel, and take actions intended to incorporate the externality costs of such energy option for suppliers and consumers, as a form of encouraging a more rational use of those sources of energy, through the regulation and/or market mechanisms.
- To develop a renewable sources market (wind and solar energy, small hydroelectric power stations, biomass) in the mid and long term, making them more competitive and ensuring remuneration for investors, cutting risks and bringing more investors to this area. In addition to specific auctions for renewable energy suppliers, potential options include feed-in tariffs and other tax methods aimed at promoting positive impacts linked to renewable energies.
- Governments and multilateral credit entities should promote the increasing use of biofuels, with programs that encourage offering and enabling the technological changes required by the demand. It is important to use the best practices in the industry without affecting each country��s main ecosystems.
- To develop the research on renewable energy sources to be applied in industrial processes, urban solutions, facilities, etc. Governments should develop a tax system intended to encourage research and corporate investment in training skilled professionals in this area, in addition to offering adequate resources for the realization of these goals.
efficient equipment, and installing of intelligent home meters are actions considered crucial by specialists for promoting energy efficiency. Governments should be more restrictive regarding the commercialization of inefficient equipment.
- Overall access to good quality energy (and renewable energy, whenever possible) is critical for social inclusion. Programs intended to abolish energy exclusion can improve the quality of life of populations with low human development index, while creating higher energy efficiency by reducing the consumption of less efficient energy sources, like firewood.
Water Resources
- To tax water consumption, whenever and wherever possible, respecting the characteristics and limitations of each region, as a way of encouraging efficient actions regarding its use. The permanent measurement of water consumption, in addition to measures to fight its illegal use, is a crucial action to rationalize the employ of water resources.
- Resources obtained from water consumption taxation should be invested in incentives aimed at basin recovery and waters supply protection. Additional incentives worth investment include environmental services aimed at safeguarding watersheds, protecting riparian Forest, and reforesting degraded areas.
- Water resources should be managed in a decentralized and transparent system with the ability to implement management and regulation of economic tools and methodologies intended to survey the various uses of said resources.
- Since irrigation is a key factor when it comes to the use of water resources, with considerably inefficient processes, it is important to use more efficient irrigation techniques which rationalize water consumption and draw on local expertise.
- Sewage collection and treatment systems are critical for protecting water resources and their long-term availability, thus preserving the quality of drinking water. Nations must universalize their sanitation systems through different solutions aligned with local characteristics and needs.
- To develop a governance model in the freight transport sector which better defines the accountabilities and responsibilities of sectorial policy makers on planning and regulation, of executive agents, establishing additional control and incentives so that businesses and individuals may use newer, more efficient vehicles, and the tax system may discourage inefficient corporate logistic decisions.
- To boost investments in transport facilities and adjust them to the domestic needs (especially in developing countries) using more efficient forms of transport whenever possible, focusing mainly on the planning activity (by developing the capability of the various modes and of intermodal transport integration), on the execution (using more sustainable and durable goods, respecting the labor law and offering skilled manpower training), and taking into consideration the need of maintenance and inspection for the adequate use of transport systems.
- Urban mobility should be planned in conjunction with land use occupation, encouraging the supply of public and private services near major intermodal integration stations, and the rational displacement of city inhabitants. The planning should also include incentives for rational use of private vehicles, collective transport quality inspection, and the optimization of the various modes, so as to explore the capabilities of each mode and their complementarities.
- Fare integration, together with system predictability and information available to users (like the time it takes to arrive to bus stops or train stations) �V and the exclusive use of urban facilities in some cases �V should prevail in public transportation, thus encouraging the use of public transportation system instead of private transportation. Solid Waste - To promote the integrated management of urban solid waste, taking into account the solid waste management hierarchy (non generation, reuse, recycling, composting, final disposal), specific characteristics of each location; to plan the integration of the entire chain involved on a long term basis, and to train local management teams. - The solid waste management improvement should take into consideration the activity of low income people who make their living from inadequate waste disposal processes. With the implementation of selective collection, volunteer delivery sites and the entire well-planned recycling chain, these people could be included in the process, thus adding to the enhanced use of recycled material and the upgrading the living conditions of such workers. - It is necessary to invest in the improvement of databases, which should contain reliable information showing the real situation of cities, and enabling the quantification of the goals to be attained, including the amount of required investments. This could facilitate waste management planning in individual countries and the establishment of goals to be met. - All agents (communities and both the private and public sector) involved should be aware of their shared responsibility in waste management. This awareness should not simply refer to information, but rather to a cultural change as well, since some good practices, like food waste reduction and choosing more durable or reusable goods, have not been quite well perceived yet by part of the population. It is important to promote green consumption policies among individuals, corporations and public entities, with consumption goals for products made with recycled material, whenever feasible. - To propose motivational actions to the recycling industry, including the development of industrial clusters for these activities and lower taxes for recycled products. - Setting goals for the acquisition of recycled material goods, especially for major state-owned corporations and governments. This practice would be influential in the public sector by showing the best practices to be adopted by other businesses when purchasing their products. - To take into consideration, whenever feasible, the incineration of nonorganic and nonrecyclable waste associated with steam and/or energy generation, especially in big cities, and invest in composting and biomethanization for the correct use of naturally biodegradable organic waste. Agriculture - To improve actions related to the use of technologies intended for agricultural production sustainability, offering incentives to producers adopting good agronomic practices planned to minimize greenhouse gas emissions, in addition to improving the productive processes and rearranging the energy matrix with the purpose of reducing greenhouse gas emissions. - To increase the industry competitiveness, intensifying technological developments in sustainable production systems, soil-plant system, microbiology and recovery of degraded areas. - To improve the quality of agricultural products: the market requires special products with a low degree of impact on the environment which causes no risks to human health from chemical contamination (pesticide remnants) and biological contamination (presence of pathogenic microorganisms). - To improve the production processes and rearrange energy matrices with the purpose of reducing greenhouse gas emissions. - To offer compensation for environment services provided by small farmers or family farming. Farmers should be rewarded for preserving the environment either with payment in money or with production incentives. - Implementation of studies on Climate Risk Zones as a basis for a public policy focused on an efficient production regionalization. - To establish special lines of credit to benefit the modernization of properties, offering a climate insurance coverage to farmers in investment operations, based on the Climate Risk Zones. Forests - Governments should encourage businesses to adopt decentralized policies for developing the forest base, with the purpose of avoiding extensive monoculture and increasing the participation of farmers in its supply, promoting social inclusion. - To further the consumption of forest chain products as an alternative to the mineral chain. To issue a nationwide campaign showing the environment edges arising from the energetic use of planted forests. - Governments should work together with forest management organizations in order to denounce and prevent degrading work practices or any other questionable social practices. - Deforestation is a major source of GHG emissions, mainly in tropical developing countries. Therefore, it is very important to develop new projects, and consolidate and integrate existing ones, which seek to generate income from the maintenance of forests and protected areas. The main initiative at this moment is the payment for environmental services (particularly REDD), which promotes economic incentives for environmental preservation. - To create strategies that foster sustainable use of natural resources and the development of forestry activities (such as sustainable forest management), associated with social inclusion programs. Governments should also create incentives for the implementation of technologies that improve the productivity of non-wood forest goods, including technical assistance to small-scale producers. - It is essential to plan the expansion of agricultural activity to occur primarily in already modified or degraded areas, thus preventing the clearing of new locations. In order to succeed in this effort, governments should enforce preservation laws, consolidate a network of protected areas and promote the use of more advanced technologies for the management of agriculture and livestock, restoring the productivity of abandoned or underutilized land. Finance - Development of green criteria applied to government fiscal incentives in times of Crisis, so that the actions intended to reduce the impacts of economic slowdown on society do not include environmentally predatory measures. The transition to a green economy requires a high amount of investment, and such anti-Crisis packages are a helpful tool to do it. - Increasing the financial support to infrastructure works in developing countries is a key factor to their sustainable development. However, governments should outfit their control and inspection institutions on a proportional basis (especially in the environmental sector) so that the benefits arising from such works are not overcome by the project's negative impacts. - A tax reform which promotes a clean technological innovation, the preservation of valuable natural resources, and the payment of environmental services, in addition to a social cost price internalization in goods and services, is a key factor for the financial system to allocate - on a optimum and sustainable basis - the resources available for investment and consumption. A system intended to foster sustainable materials and solutions in public purchase bids should also be considered an efficient strategy to encourage the private sector to adopt better practices. - The finance system regulation should search and promote high social-environmental indicators solutions, punishing investments and financial resources applied to predatory solutions with a high social cost. - Governments should encourage financial institutions to expand micro-credit participation in their portfolios, as a form of offering banking system benefits to disadvantaged people, thus promoting the development of entrepreneurial actions within those communities. It is crucial that such expansion comes together with education and information policies regarding the system operation and its risks.


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Royalty Free Music & Incredible Ways To Customize It
Royalty Free Music — Corporate & Guitar (Acoustic) & Refined
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The off-campus programs are offered at a significant discount compared to traditional undergraduate tuition rates. Additionally, students who have already completed required coursework prior to admission take fewer courses and pay less for the program.
Note that the cost chart below is based on current 2015-2016 academic year tuition rates and fees. Tuition and fees are subject to an increase every July 1st.
Total Program Cost = $27,630
Financial Aid
Financial aid is available for students who qualify. Applicants applying for financial aid must first apply for a PIN at www.pin.ed.gov and then complete the FAFSA (Free Application for Federal Student Aid) at www.fafsa.ed.gov. Enter school code 002140 to send your FAFSA to College of Our Lady of the Elms.
For information regarding financial aid, please call 413-265-2249 or e-mail firstname.lastname@example.com.
We are a Catholic liberal arts college founded by the Sisters of St. Joseph of Springfield, Massachusetts.


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Fight off the winter chill in this Vaquero jacket from Fox. It features a full length zipper, two front and two chest pockets, epaulettes and Fox branding on both sleeves.
- Custom Fox buttons and tags
- Filling: 100% cotton
- Four front pockets, one inner pocket
- Full length zipper
- Imported
- Lining: 100% Polyester fabric
- Rib-knit collar, cuffs & waist
- Shell: 60% wool/25% polyester/15% viscose
- Imported
- Brand: Fox
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
Manufacturer direct items are shipped directly from the manufacturer. These items are not available for international or expedited shipping.
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Brandon Matthew Lloyd (twitter: @mrblloyd)
Position: WR
Height: 6-0 Weight: 192 lbs.
Born: July 5, 1981 in Kansas City, MO
High School: Blue Springs
College: Illinois (school history) (Lloyd college stats)
Drafted by the San Francisco 49ers in the 4th round (124th overall) of the 2003 NFL Draft.
Weighted Career AV (100-95-...): 41 (2177th overall since 1950)
1-time Pro Bowler (fine print)
Other SR Links: College Football at Sports-Reference.com


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Wrestling Team Heads To The Palestra For Annual Keystone Classic
TWITTER: Princeton Wrestling l Princeton Athletics l Keystone Classic
2012-13 Season Preview
Last year, the Keystone Open served as a launching point for the likes of Daniel Kolodzik and Garrett Frey, and head coach Chris Ayres hopes it can do the same for several other Tigers this season.
One year after placing an Ivy-best fourth at the Keystone Open, hosted by Penn at the Palestra, Princeton returns to compete with 14 other programs at the one-day event. A tentative schedule can be found at the bottom of this release.
Six Tigers placed last year, including Frey, who reached the final at 125. Junior co-captain Dan Santoro (174) also placed fourth in the event. Frey reached the finals at 125, where he fell 8-3 to nationally ranked Levi Mele of Northwestern. It's possible that Frey could see Mele once again, as both are likely to compete at 133 this year.
Princeton is coming off a solid start to its season last weekend at the Binghamton Open, where four Tigers placed. Three (Abe Ayala, Scott Gibbons and Judd Ziegler) were freshmen making their collegiate debuts, while the fourth was senior co-captain Zach Bintliff.
Both Ayala and Ziegler compete at 165, and both could see a pair of Top 20 opponents in 14th-ranked Pierce Harger of Northwestern and 20th-ranked Ryan LeBlanc of Indiana. Both Bintliff (149) and Gibbons (184) could see more open fields, as neither weight features a competitor currently ranked inside the Top 20.
Tentative Keystone Schedule
9:00 a.m. - Championship First Round
10:00 a.m. - Championship Second Round
12:00 p.m. - Championship Quarterfinals and Consolation First Round
2:00 p.m. Consolation Second Round
3:00 p.m. - Championship Semifinals and Consolation Third Round
4:30 p.m. - Consolation Fourth Round
5:15 p.m. - Consolation Semifinals
6:00 p.m. Championship Finals, Third and Fifth-Place Matches


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What You Should Know About Your Drugs
Pharmacy Author:
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Jay W. Marks, MD
Jay W. Marks, MD
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Medical and Pharmacy Editor:
William C. Shiel Jr., MD, FACP, FACR
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Whether synthetic or natural (herbal), drugs are intended to act on the body. There always is a chance that they will produce effects that we do not want. Also, if two or more drugs are taken at the same time, there is a chance that one drug will interact with another drug in either a positive or negative way. This does not imply that the drugs are bad, but rather that they should be used carefully in order to reap the greatest benefit while minimizing unwanted side effects. Indeed, when used properly, most drugs approved by the Food and Drug Administration do more good than harm. Below are ten questions that apply to most drugs and are worth discussing with your healthcare provider. Most of these issues are addressed by the information that is provided with the drug.
Medically Reviewed by a Doctor on 11/10/2014
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
Back to Medications Index


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by Larry Marion / Director of the Not Fade Away Gallery
Click here for a photo gallery featuring rare images of the Beatles and the Rolling Stones, from the Bob Bonis Archive. The Lost Beatles Photographs: The Bob Bonis Archive 1964-1966 and The Lost Rolling Stones Photographs: The Bob Bonis Archive 1964-1966 are available at the Museum store and for viewing at the Library and Archives.
Bob Bonis may have been the luckiest person in the world. From 1964 through 1966, he served as both the Beatles' and Rolling Stones' U.S. tour manager. For the Beatles, that included all three of their U.S. tours and it covered the Stones' first five US tours.
In addition to being a great tour manager, Bonis was also an amateur photographer of extraordinary talent. He brought his camera on the tours and captured historic and iconic images of what would become two of the most important bands in the history of rock and roll. [Pictured above: The Beatles relax poolside and play with a balloon. Bel Air, California, August 1964. / Photograph by Bob Bonis © NFAgallery.com]
The Beatles and Stones are among the most photographed groups in history, but virtually all of the images we've come to know and love were posed or staged photographs, taken by either a photojournalist or a photographer hired to do a photo shoot for an album or magazine or for publicity or concert shots. Candid, unguarded and intimate photos, especially from this time period, are extremely rare. But Bonis was an insider. He was their tour manager and their friend and guardian. He had unqualed access.
As a trusted member of their entourages, Bonis was allowed to capture images of the groups not only onstage, but also backstage preparing for concerts and talking with other stars, traveling from city to city, relaxing in those rare moments of personal downtime and just being themselves. In the case of the Stones, he also extensively photographed them recording at both Chess Studios in Chicago and RCA Studios in Hollywood, California, and rehearsing for television and film appearances. [Pictured left: A revealing photograph of Mick Jagger at the Fort Harrison Hotel in Clearwater, Florida, in May 1965. / Photograph by Bob Bonis © NFAgallery.com]
Bonis spent his earlier career as an agent and manager with a variety of jazz artists who often performed in the mostly mob-run clubs in New York. Standing more than six feet tall and weighing around 200 pounds, Bonis cut an imposing figure and was the kind of no-nonsense guy that didn't stand for any shenanigans.
When the Rolling Stones were set to come to America, their U.S. agent knew he had to get someone that could handle the band that had earned a reputation as the bad boys of rock and roll. He thought of his old friend Bob Bonis and convinced him to take the job, even though Bonis was not a rock and roll fan or anxious to go on the road with a bunch of troublemakers. When he met them in June of 1964, he quickly found that they were not a bunch of hooligans, but rather a group of kids in their early twenties who were being positioned by their manager, Andrew Loog Oldham, as a counterpoint to the Beatles clean and wholesome image. Bonis and the band clicked.
A few months later, when the Beatles were ready to embark on their first full U.S. tour, they asked the Rolling Stones' management for advice, and Bonis was recommended and soon thereafter hired. Bonis was so good at his job that the Beatles retained him for all three of their American tours. In that time, he took almost 900 photos of George Harrison, John Lennon, Paul McCartney and Ringo Starr. He stayed on as the Rolling Stones' American tour manager through 1966, when the band took a break from touring. While traveling with the Stones, Bonis captured almost 2,700 images of them. After his time with the Beatles and Stones, Bonis went on to work with artists, including Simon and Garfunkel, the Lovin' Spoonful, Chicago and Frank Sinatra.
During his lifetime, Bonis only ever allowed a small handful of his photographs to be published in a teen magazine. He felt it was a privilege and honor to have worked with these great stars and that it would be inappropriate to try and capitalize on that relationship and good fortune. Instead, Bonis kept the negatives and photographs for his own personal enjoyment. He always refused offers to publish them or tell stories from on the road with the Beatles and the Stones. [Pictured above: John Lennon in a somber moment on a plane en route to St. Louis, Missouri, August 21, 1966. Only five shows before their last ever U.S. concert. / Photograph by Bob Bonis © NFAgallery.com]
Bonis passed away in 1992, and the negatives, slides and few prints he made remained "lost" or hidden from the public until 2008, when I met Bonis' son Alex. I convinced him that we should honor his father's legacy and unveil these unique and remarkable photographs that his father had taken during a turning point in the careers of the Beatles and the Rolling Stones, coming to and poised to conquer America.
We formed a company and embarked on a journey to let fans and collectors see and have access to these never-before-seen shots of John Lennon, Paul McCartney, George Harrison, Ringo Starr, Mick Jagger, Keith Richards, Brian Jones, Bill Wyman, Charlie Watts, Ian Stewart and their managers, friends, fellow musicians, engineers and fans.
This adventure led to the publication of two books: The Lost Beatles Photographs: The Bob Bonis Archive 1964-1966 and The Lost Rolling Stones Photographs: The Bob Bonis Archive 1964-1966. Rock and Roll Hall of Fame and Museum curatorial director Howard Kramer noted: "The Bob Bonis collection is an unmatched view into the inner circle of the most iconic groups of all time. It's illuminating, humanizing and intimate."
Keith Richards used several of Bonis' photos in his autobiography, LIFE, published last year, and several others are going to be featured in other books coming out this coming year to celebrate the 50th anniversary of the Rolling Stones.
[All photos courtesy of Larry Marion/Photographs by Bob Bonis © NFAgallery.com]
About Larry Marion:
Larry Marion is recognized as one of the world's leading authorities on rock and music memorabilia, especially concert posters. He has worked with many of the leading auction houses, set several world-record prices for Beatles memorabilia, and written and designed 16 catalogs of music-related memorabilia. Larry is one of the owners, founders and directors of NotFadeAwayGallery.com, which exclusively represents the photography of Bob Bonis. He lives in Brooklyn, New York, collects memorabilia related to stand-up comedy, music and the 60s, and can be contacted at email@example.com.


text: Why Sex MattersHere's an anti-aging treatment that's more fun than Botox: sex! Some healthy recreation between the sheets can actually help you look and feel younger. It's good for your heart; it aids sleep; it can even ease menopause symptoms. Well, that's great, you say — but what if you can't get no satisfaction? Hormonal changes, relationship difficulties, and the constant specter of stress can make good sex more elusive in midlife than ever before. Here, five top experts on women's health talk candidly about the bedroom issues we most often face and what you can do to heat up your sex life.The expert: Marianne Brandon, PhD, sex therapist and coauthor of Reclaiming Desire: 4 Keys to Finding Your Lost LibidoWhy is it important to maintain a healthy sex life? Brandon: It's about much more than the physical experience of sex; it's about living fully. When we allow ourselves to completely experience pleasure, it helps us feel awake and alive. So sex is an incredibly important anti-aging technique.If a woman feels that she's not as sexual as she used to be, what's the first thing she should do?Brandon: Use it as an opportunity to further her own sexual evolution. Women develop a certain understanding of who they are sexually when they're in their 20s and then go wrong by believing they have to be just like that throughout life. It's so not true! We don't expect ourselves to like the same types of food or music at 45 that we did at 25, and it's the same with sex. Ask yourself questions such as, "I used to like being touched this way, but how do I like to be touched now?"How can a woman learn to feel more sensual?Brandon: Most of us operate solely on intellect these days, but the more you think, the less you're feeling in your body, which is essential for sensuality. I give clients mini workshops in which they explore the five senses, to pull themselves out of their brains and into their bodies. For one week, focus on one sense fully throughout each day. During the taste week, really examine the texture and taste of food. During the scent week, light incense or candles and wear perfume. Another idea is to think of a woman who manifests sensuality — like Ellen Barkin. Imagine what it feels like to be her, and then practice at it. You can practice while you're washing the dishes or getting dressed for work, and the more you do it, the more natural it will feel. Remember, sensuality doesn't just happen; you have to cultivate it, just like intelligence, athleticism, or any other aspect of yourself.How do you access your sensual side if you have a houseful of kids or you're working overtime to run a business?Brandon: You can do it in a way that your kids or your employees will never pick up on. Buy a cashmere blanket and curl up in it while you watch television. Buy yourself wonderful chocolates and eat a piece slowly for dessert. Pay attention to your body every day by exercising: dance, yoga, even just stretching helps you get more in tune with your physical self. Sensuality should be a general part of life, not something you save for Friday night.What's a good way to spice up a stale sexual relationship?Brandon: Try slowing everything down. Think of enjoying it like a meal during which you notice every aspect of the experience. Or do what I call taking your partner to sex school. Make love to your partner exactly the way you want him to make love to you — approach him, look at him, and touch him the way you want him to approach, look at, and touch you. If that's outside your comfort zone, find a sex scene in a movie where the woman is treated a certain way and ask your partner to watch it with you. He'll get the point.Why a Woman's Sex Drive Is ComplicatedThe expert: Joann Pinkerton, MD, president-elect of the North American Menopause Society and director of the Midlife Health Center at the University of Virginia in CharlottesvilleWhat is it about being over 40 that can make sex go less smoothly?Pinkerton: Perimenopause causes a host of hormonal fluctuations that can contribute to libido problems. This time of life is sometimes worse than menopause because hormone levels can be all over the place: Your levels of estrogen and progesterone can fluctuate widely — sometimes going much higher or lower than before perimenopause. Testosterone, largely responsible for your sex drive, tends to decline in your 40s, around the same time that perimenopause begins. Then, in menopause, your estrogen level usually falls steadily, which, along with a lower level of testosterone, lessens desire further. That said, hormones aren't the whole story. This may be a significantly stressful time in our lives. Our careers may be at their busy and time-consuming peaks. We may have concerns about our children. Our own parents may be failing and need more care. Any of these things can extinguish the libido's pilot light.The upside is that simple lifestyle changes can help. Just getting regular exercise can relieve stress and hormonal mood swings and give you energy for the things that are important to you, like sex.Why is it that women seem to experience the lion's share of libido problems?Pinkerton: Women are complex — much more so than men in this arena. When patients ask "What can you do to fix my libido?" my response is that it's complicated. We have to look at hormonal status, general health, relationship status and stress, to find out what's going on.Is it common not to seek out sex the way you used to?Pinkerton: Very. As women age, they often find that they stop having the kind of everyday sexual urges they used to have. It doesn't have to be a problem; you can redefine what successful sex is to fit your own and your partner's wants now. In your 20s, such sex may have meant simply getting aroused and having an orgasm. Now it might be more intimate: giving massages or stimulating each other with or without an orgasm. What's important to think about if you're dating? Pinkerton: STDs. You have to use a condom, which surprises a lot of my patients. Women at this age are more at risk for herpes and HPV than younger women are. You also have to think about pregnancy prevention. The next-highest unintended pregnancy rate after teenagers' is actually that of women in their 40s.What if you have kids at home? Finding time to be intimate can be difficult.Pinkerton: Morning is a great time. The house is quiet, and your sex drive is high because testosterone levels are at their peak in the morning. If you have a teenager who goes out until his midnight curfew, maybe make love at seven in the evening. Or try for later in the weekend if you're too exhausted on Friday night.Low Libido? Blame AgingThe expert: Mary Jane Minkin, MD, clinical professor of ob-gyn at Yale and author of a Woman's Guide to Menopause & PerimenopauseWhich symptoms indicate that hormone changes are causing a low libido?Minkin: Vaginal dryness or pain during intercourse. Before I do any fancy workups on a patient who's experiencing these problems, I prescribe a vaginal estrogen cream, which you apply directly to the labia. That solves it for many women. Just about anyone — even breast cancer patients — can use estrogen cream.Now, let's say we fix the dryness or pain, but the woman still has no interest and she knows it isn't a lifestyle or a relationship issue. We'll test her hormone levels, and then we might try systemic estrogen in pill form or testosterone. Unfortunately, in the United States we don't have an FDA-approved testosterone for women, so I'll do an off-label prescription of a very small dose of the type approved for men or try a testosterone cream that can be applied to the thigh or labia. This increases blood flow to the genitals, aiding arousal. There are a few adverse side effects with testosterone — like increased facial hair and acne — but with a small dose, it's not a big deal. I had one patient call me years ago to tell me that she was noticing a few stray facial hairs after starting testosterone. I said, "Okay, we'll just lower the dose." I'll never forget the tone of her voice when she said, "No, no, we won't!" The effects were worth the slight downside. With any of these treatments, I tell patients to try them for three months. If they don't work, we reevaluate.What other age-related health issues cause libido problems?Minkin: As we get older, we take more meds, and our partners do too. Some drugs do a very dirty job on sex drive. The classic is SSRI antidepressants, such as Prozac. Cymbalta — a newer antidepressant, called an SNRI — may have less of an effect, which is the case with Wellbutrin, also not an SSRI. If you really like your SSRI but don't like the sexual side effects, some docs add a prescription for a small dose of Wellbutrin to solve the problem. Drugs for high blood pressure are notorious for decreasing erectile performance, and they can also block orgasmic response in women. Your doctor can switch your medication. Hypothyroidism, which is a huge problem for women in this age group, is subtle and is associated with decreased sexual response. Ask your doctor for a TSH [thyroid-stimulating hormone] screening test, which we now recommend for all women over 50. It can be performed in her office.Okay, so let's say the problem isn't health-related but has to do with getting used to the idea of aging.Minkin: What you think of yourself is crucial. As my good friend Dr. Ruth says, "The most important organ in the body for sexuality is between the ears, not between the legs." Many 40-plus women feel they're not as attractive as they once were, but if you ask me, it's bullshit. The young, immature starlets on their third trip to rehab are not so alluring, really. The interesting thing is that when we research societies where age is valued, women have fewer menopausal symptoms, like hot flashes, so there's something to be said for appreciating your age.We so often talk about over-40 sex being problematic, but aren't some women having the best sex of their lives during this time?Minkin: Absolutely. Menopause can be liberating, because you no longer have to worry about getting pregnant or deal with painful conditions like endometriosis and fibroids. For a lot of people, menopause turns out to be a blessing for all its sexual benefits. Is Sex Better at 25 or 45?The expert: Laura Berman, PhD, author of The Passion Prescription: Ten Weeks to Your Best Sex — Ever!Why is sex so healthy for us? Berman: There are several reasons. It boosts the immune system and combats depression, and, because it's exercise, it promotes cardiovascular blood flow. You burn up to 50 calories during 30 minutes of sex, as compared to about 35 calories sitting and reading for 30 minutes. It also increases your genital blood flow, which helps keep your sexual response healthy. It's the "use it or lose it" phenomenon: Physiologically and clinically, we've found that the more often you have sex, the more you'll respond sexually and the more "in the mood" you'll be.Why is sex essential for a good relationship?Berman: The more sexual you are as a couple, the better off you'll be. We've found in our national research that the number-one predictor for emotional connectedness in a relationship is the level of sexual satisfaction of the couple. You acquire a sense of closeness with your partner by having sex. It creates an intimate, romantic world for just the two of you. Can sex help relieve menopause symptoms? Berman: Yes. The endorphins sex and orgasms release can help with moodiness and sleeplessness.Is sex better at 25 or 45?Berman: Here's the thing: A woman in her 20s may be physically in her prime, but that's just one small part of her sexual response and experience. From what I've seen, older women are more confident and empowered, and they feel more comfortable being uninhibited — all of which gives them a huge sexual advantage over the twenty-somethings. It's good news all around: A doctor can often fix the physiological issues that women over 40 may be dealing with, and the emotional characteristics that older women possess are really the essential ingredient for a great sex life.What if your partner has erectile dysfunction, or ED? Berman: Men who have ED typically shut down sexually. They won't hold hands or be romantic because they associate those things with the lead-up to sex and they don't want to face potential failure. So do make an effort to talk about it as a problem you can tackle together, which may lessen his anxiety. Offer to go to the doctor's appointment with him, even if you just sit in the waiting room. Once he's been treated, you'll likely have an increase in your sex drive too. We know that the partners of successfully treated men also get a lift, because men who are more sexually confident reach out to their partners more, engage in more foreplay and have less anxiety, which lessens their partners' anxiety as well.What's crucial is to approach treatment as a team. Your partner needs to understand that just because he took his pill before dinner and he has an erection by the end of the meal, it doesn't mean you're ready to jump into bed. In other words, you don't need to "use" the erection as soon as it happens. Viagra, in particular, has a 12-hour half-life, so he can get the erection, it can soften during foreplay, and then he'll get the erection back.What are some ways to achieve a better orgasm?Berman: Decreased vaginal blood flow, which can often be helped by hormone therapy, is one reason midlife women experience less genital sensation or have less intense orgasms. Vibrators can help, and I actually prescribe them to my patients to help them reach different goals. For example, with a mini massager, you can learn to stimulate orgasm by varying the pressure on different areas of your genitals, or you can learn how to achieve orgasm more easily by placing it on your clitoral area, between you and your partner, while you're having intercourse. Weakening of the pelvic floor muscles causes less intense orgasms too. Childbirth is the most common culprit; women who've had several vaginal births have the most trouble, but even women who've had cesarean births can experience it. Regular Kegel exercises, in which you contract your vaginal muscles as if you're stopping the flow of urine, can help.How to Feel SexierThe expert: Christiane Northrup, MD, ob-gyn in Yarmouth, Maine, and author of The Wisdom of MenopauseWhy do so many over-40 women simply find sex less appealing? Northrup: What's really happening with women's libidos after 40 is that there's this hormonal shift that allows unresolved anger, if you have it, to show itself. You're mad at yourself for allowing your family to put you last, you're irritable at work, and none of these sentiments help you feel sexy. The good news is that these changes, in my opinion, are actually designed for women to clean up their pasts and give birth to their best selves.Is this a universal problem? Do all women feel less sexual as they age?Northrup: No, which is why we can't say that the menopausal transition is solely responsible for decreased sex drive. Boredom in relationships is a real issue: We know from research that the number-one predictor of a really good sex life at midlife is a new partner. With somebody new, you don't have all that history together. How can we learn to feel sexier?Northrup: Women at midlife need to be able to see themselves as the ideal sexual woman no matter whether they're single, married, gay, or straight. Find out what turns you on by making pleasure a priority in your life. Let me get completely graphic: Set aside several times a week for self-pleasuring. Act as if a rock star (or whoever does it for you) is coming to your home and you are going to seduce him or her. Put fresh flowers in the bedroom, make the sheets all sexy flesh tones or red silk — whatever you like. Turn your bedroom into a boudoir and practice. The exercise will help you fall in love with yourself.It's important to learn to communicate what we want from our partners, isn't it? Northrup: It's essential. We are taught backward: Men feel they should know what to do during sex, but it's actually a woman's job to decide what she wants and tell her mate how to provide it. That's why it's so good that we're seeing the interest in classes like belly dancing and pole dancing — things that help you find your inner erotic creature, which is not at all about being sexy for a man. Women are finding that their ability to be seductive and experience pleasure is unlimited. It's very exciting!More from Your Over-40 Health Guide Originally published in MORE magazine, May 2008.


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Best Sellers
Our most popular gear based on what customers are buying.
A classic full zip for outdoor enthusiasts to wear on or off the trail, the Logo Full Zip incorporates athletic-inspired ribbing along the cuffs and hem. Zip-in to this comfortable hoodie for cool weather treks and stay warm beneath its soft interior.


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Courtesy: Spencer Farrin (Moscow, Idaho)
|Kiser 5th at NCAA meet
FAYETTEVILLE, Ark- University of Idaho junior Hannah Kiser finished 5th in the women's 3000m in her second-consecutive NCAA Indoor Track and Field Championships on Saturday.
Kiser posted a time of 9:07.76, just behind Iowa State's, Betsy Saina who finished the race with a time of 9:07.34. Dartmouth junior Abbey D'Agostino won the race with a time of 9:01.08.
After having set the Western Athletic Conference and Idaho school records in the 3000m, Kiser was also able to capture the WAC and school records in the mile this season.
With the indoor season at an end, Idaho now shifts their focus to the outdoor track and field season. Competition starts in two weeks with the Whitworth Buc Scoring meet on Saturday, Mar. 22 at Spokane, Wash.


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Woodruff Memorial Library Programming and Outreach Coordinator Kimberly Gallegos reports that Arifa and Naseem Bibi from the International Relations Organization at Otero Junior College presented an informative and entertaining program for the After School PLAY (Promoting Literacy & Art for Youth) on March 13. Their program was about life in their native Pakistan.
The meeting started with the usual refreshments, popcorn and a drink, said Gallegos. Since the day was nice, they enjoyed the new patio area.
After the presentation, the children had the opportunity to see and hold Pakistani currency, handmade purses, wallets and hats. The children were excited to hear what life is like in another country. They asked a lot of questions, such as "Do you have McDonald's?" and "Do you have cars?" They were also shocked to learn that 1,000 Pakistani Rupees is only equivalent to $10 in U.S. currency.
Gallegos said they all had a great time and laughed about some of the questions. The children in this program are kindergarten through sixth grade.
Location, ST | website.com


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|Honors continue to come Iupati's way
University of Idaho senior guard Mike Iupati is a Walter Camp All-American after a stellar season with the Vandals. The announcement was made at the Home Depot ESPNU College Football Awards Show. Iupati was one of three finalists for the Outland Trophy to honor college football's top interior lineman - a number that totals more than 1,000 offensive and defensive players. Multi-honored Nebraska defensive tackle Ndamukong Suh was the Outland winner. The other finalist was Oklahoma State's Russell Okung. This year's Walter Camp Team is the 120th. The annual awards banquet is at Yale University at New Haven, Conn., in January.


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Hindi Zahra – "Beautiful Tango" (unplugged) from Wedge Mgmt on Vimeo.
Not long ago we introduced you to Hindi Zahra, a truly charming Parisian vocalist mixing jazz, blues, and folk. Today, we're excited to share a few goodies from one of our favorite newer acts.
Yesterday Hindi Zahra premiered her newest single, "Fascination," on Filter with a free download. The song is warm, folky, and perfect for an afternoon hum on our ranch (assuming we had a ranch). Find it below!
Interview Magazine has dropped an insightful feature on Hindi, covering everything from her role models and her view on some flattering comparisons (Billie Holiday, Janis Joplin, Patti Smith) to the influence of film on her music.
The feature also touches on Zahra's songwriting process, which is particularly intriguing. Ignoring pressures of peers to record, she took her time to start an album when she was "ready" – that time ended up being at age 28. Now 32, the graceful artist exhibits a peaceful patience in her approach to her music:
When I write, I write step-by-step. I just write a few words, and then I come back to the words. I have a lot of songs that have just four words. It starts like this, and I came back one or two years after. I work on it when I have a feeling to do it. I never force myself to do something. I think that I have to respect the inspiration. I just understood that you have to leave things, feel things, travel, meet people, get alone—and after, the music and lyrics come.
And if you haven't already taken a peek, above you'll find a video from an enchanting acoustic performance of "Beautiful Tango," the song we shared with you earlier this month.
Look out for the digital release of Handmade on September 26th. Also be sure to check for Hindi on tour beginning September 30th.
Hindi Zahra – "Fascination" [MP3]


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Late Comeback Effort Not Enough, Baseball Drops 8-6 Decision to Rider
Box Score
Despite taking a 2-0 lead in the first, miscues by the Tigers during the middle innings allowed Rider to respond and hold off a ninth inning rally to defeat the Princeton baseball team 8-6 Wednesday afternoon at Clarke Field.
Turning Point of the Game: Princeton looked to be in control over the opening frames, holding a 2-0 advantage and only allowing one Bronc base runner off a walk. Things broke down in the top of the third as Rider scored three runs off a Jerry Mulderig triple. The Broncs' one-run lead quickly expanded to 6-2, as they capitalized on four hits and two Princeton errors over the fourth and fifth frames.
Player of the Game: Freshman Danny Hoy went 4-for-5 with three RBI and a pair of runs to lead offense. The team's leader in doubles, the second baseman hit his 13th and 14th in the first and ninth innings, respectively. Hoy also stole a pair of bases, improving him to 12-for-13 on the year for a team-best.
Batter of the Game: Alec Keller went 3-for-4 with three runs and a walk in the leadoff spot for Princeton, improving his season batting average to .378. The outfielder also had a double and a stolen base Wednesday.
Pitcher of the Game: Reliever Danny Thomson tossed 1.1 scoreless innings over the final two frames. In five batters faced, the sophomore had a strikeout and gave up only one hit.
Nearly a Ninth Inning Comeback: Down 8-4 entering the ninth, Princeton began to put together a last chance comeback effort. With one out and a runner on first, Danny Hoy opened up the scoring with an RBI double to left field. Following an out with runners on the corners Alex Flink sent an RBI single to left field, but the Tigers were unable to keep their chances alive before conceding the final out.
On Deck: Princeton (12-26, 9-7 Ivy) concludes the regular season this weekend with a home-away four-game series versus Cornell. The Big Red head to Clarke Field on Friday, Apr. 26 for a doubleheader beginning at 12 noon. The series concludes two days later in Ithaca, N.Y.


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New Jersey laws dictate the public hearing process for both the Planning Board and the Zoning Board of Adjustment.
A printed Agenda shows the order in which items are heard or discussed. The Chair may change the order. There is a "curfew" indicated at the top of the Agenda. The Board may opt to hear new items after the curfew. If the Board opts to observe the curfew, a continuation date is announced for any uncompleted applications. Generally, this announcement satisfies the Public Notice requirement. To confirm a rescheduling, please call the office (973-331-3319). Agendas can also be found at the following links for the Planning Board and the Zoning Board of Adjustment.
The Planning Board and Zoning Board of Adjustment are quasi-judicial bodies meaning each operate similar to, but not as strictly as a court of law. Thus, a hearing is similar to a court proceeding. The Chair runs the proceedings as a judge might and the Board acts like a jury that vote on a final decision to approve or deny. The applicant provides testimony and will also have expert witnesses testify and introduce evidence in support of the case.
The Board, its staff, and the public, have the right to cross-examine these witnesses and finally, at the appropriate time, comment on the application. Applicant, their professionals and others having legal rights also have the right to cross-examination. Thus, statements should be supportable and factual. The Board is legally required to act on an application based upon the findings of fact and the proofs according to law that are presented to them. Although the Board may take public input into account, it cannot and does not act solely based on public support or opposition. The Board cannot make decisions based upon financial considerations such as "ratables" or" tax" revenues.
Anyone wishing to speak or testify at a hearing must appear in person to allow all parties the opportunity to cross-examination.
Petitions are NOT admissible into evidence and cannot be read at a hearing. Letters are only admissible if you are present to be cross-examined.
A verbatim (word-by-word) record of the proceeding is kept by electronic media format and/or by a court reporter. Therefore, speakers are directed to first provide name and address and then to speak clearly and loudly. Speakers may come forward only after being called forward by the Chair.
Public Questions and Comments
When you follow the above procedures, your contributions will have maximum impact on the Board's deliberations as they deliberate a land use application. Remember though that the Chair has the right to close the public portion of a hearing if the audience becomes unruly, and the Chair may also limit repetitive comments or irrelevant testimony. The Chair may also limit the time or number of questions or comments from one citizen in order to allow adequate time for other members of the public to comment.
These procedures are generally strictly adhered to during hearings on large or complex applications. For small or simple applications, the Chair may open the hearing for both questions and comments at the same time.
If you are not satisfied with a board's final decision, you have the right to appeal this decision within 45 days from adoption of the Board's resolution in Superior Court.
We hope that this evening and your participation in it will prove to be a rewarding experience for you, and we thank you for coming out to participate in this vital democratic process.
If you have any other questions about the Board process, feel free to call the Land Use Offices at (973) 331-3319 or email the following staff members.


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As a new user, I'm not allowed to post more than two hyperlinks here. So I have added a space after every http (ignore them and read as full URLs).
System: Debian Etch, Apache 2.2
I have a WordPress instance with multiple blogs. I would like to redirect some of the folders based on the year and month, while leaving other folders go to the actual locations.
Example: I have archives for a few years, like 2010, 2011 and 2012:
http ://mydomain.com/wordpress/myblog/2010/02
http ://mydomain.com/wordpress/myblog/2011/01
http ://mydomain.com/wordpress/myblog/2012/01
I would like to redirect all 2010 and 2011 posts to another blog with the same folder structure:
http ://mydomain.com/wordpress/myotherblog/2010/02
http ://mydomain.com/wordpress/myotherblog/2011/01
and so on.
I would like to have 2012 and beyond to go to the actual site (http ://mydomain.com/wordpress/myblog/2012/01).
I tried mod_rewrite with the following, one rule at a time to test redirection for just one year (and to expand later for other years), and none of them worked!
* RewriteEngine is already on since there are some default WordPress rewrites.
* RewriteBase is set to http://mydomain.com/wordpress/ .
* I put my rule before all the other default WordPress rules are processed.
Didn't work solution #1
RedirectMatch 301 /myblog/2010/(.*) /myotherblog/2010/$1
Didn't work solution #2
RewriteRule /myblog/2010/(.*) http ://mydomain.com/myotherblog/2010/$1 [R=301]
Didn't work solution #3
RedirectPermanent /myblog/2010/(.*) http ://mydomain.com/myotherblog/2010/$1
I've also tried the above rules with and without a fully qualified URL for the new location.
The rewrite log, with log level set to 9, did not provide any useful information. It shows that it looks at the pattern specified against the URL (as mentioned in the rule), but finally what happens is a passthrough to http ://mydomain.com/myblog/ for all URLs or a 500 Internal Server Error.
Any ideas on where I could be going wrong or any alternative solutions?


text:
Area designation is based on reported zip code:
Mt Baker/Rainier Valley: 98108,98118,98144,98178
West Seattle: 98106,98116,98126,98136,98146
Capitol Hill/Madrona: 98102,98112,98122
Queen Anne/Magnolia: 98109,98119,98199
U-District/Green Lake: 98103,98105
Ballard/NW Seattle: 98107,98117,98133,98177
View Ridge/Lake City: 98115,98125
Downtown/Bell Town: 98101,98104,98111,98121,98134
Where a zip code has residents inside and outside the Seattle City Limits the contribution is coded appropriately, i.e. either a neighborhood or "outside seattle".
"Area unknown" is largely comprised of unitemized contributions of $25 or less. It also includes: 1) anonymous contributions, 2) PO Box addresses in zip codes that are split between city and non-city residents, and 3) contributions where an address or zip code has not yet been reported.
Includes data from all reports electronically filed with the City Clerk on or before 12/11/13.
Contributionsby Area($ amount)
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See All Contributors »
Playoff Preview – NLDS Los Angeles Dodgers vs. Chicago Cubs
Wednesday 10/1 at Chicago
LA - Lowe Chi - Dempster
Thursday 10/2 at Chicago
LA- Billingsly Chi - Zambrano
Saturday 10/4 at Los Angeles
LA- Kuroda Chi - Harden
Sunday 10/5 at Los Angeles (If Necessary)
LA-Maddux or Lowe Chi - Lilly
Tuesday 10/7 at Chicago (If Necessary)
LA-Billingsly or Lowe Chi – Dempster
Results This Season
At Chicago
5/1 Cubs 3 Dodgers 1
WP Dempster LP Billingsly
SV Wood
5/2 Cubs 3 Dodgers 1
WP Gallagher LP Kuroda
SV Wood
5/3 Cubs 2 Dodgers 1 (10 innings)
WP Howry LP Park
At Los Angeles
6/5 Cubs 5 Dodgers 4
WP Howry LP Saito
SV Wood
6/6 Dodgers 3 Cubs 0
WP Kuroda LP Gallagher
6/7 Dodgers 7 Cubs 3
WP Lowe LP Zambrano
6/8 Cubs 3 Dodgers 1
WP Marquis LP Penny
About the Dodgers
The Cubs were 5-2 against the Dodgers this year, but this certainly isn't the same Dodger team they faced in May and June. Since those games the Dodgers have added Angel Berroa, Casey Blake, Greg Maddux, and a certain slugger by the name of Manny Ramirez. Joe Torre has certainly had his hands full in his first season as Dodger Manager. Not only does he have to get used to the LA lifestyle and freeway gridlock, but he has had to deal with a slew of injuries, without his top two pitchers for most of the year and had to deal with Jeff Kent's chronically red arse… The Dodgers made a hefty investment in Andruw Jones, a move that makes owner Frank McCourt wish he had thrown that $36 million towards Bear Stearns. Jones isn't even one of the top 5 outfielders on the club right now and will be lucky to make the post season roster. Two stars that have made the playoff roster despite injuries are Rafael Furcal and Jeff Kent. As of today, Torre has not ruled out starting either one. Furcal would be a huge addition at short and taking his usual leadoff spot in the lineup.
The Dodgers are rolling into the postseason on the hot bats of Manny Ramirez (.418 and a freakish .1370 OPS) and Andre Ethier (.418 and .1168 OPS) over the last 30 days. The key could be how well the young bats respond to playoff pressure. Matt Kemp (.290 35sb .799ops), James Loney (.289 90rbi .772ops), Russell Martin (280 18sb .781ops), and Blake DeWitt (.264 .728ops) are products of what has long been one of the best farm systems in baseball and along with Ethier, all 26 years old or younger. The Dodgers sport a .264 team BA; have 137 HR's, 126sb.
Perhaps more impressive is the Dodgers pitching, ranked #2 in MLB in overall pitching for the year despite missing their top 2 (by contract) pitchers for most of the year. Over the last 30 days the staff has been led by Derek Lowe, only giving up 2 runs TOTAL over his last 6 starts. Lowe carries that 0.50 era over the last 30 days along with his clutch postseason reputation to the hill in game one at Wrigley. Ideally the Dodgers would follow up with Brad Penny and Jason Schmidt, but it looks like the Blue will follow Lowe with star in the making, Chad Billingsly (4-0 3.09 last 30 days) and Hiroki Kuroda (2-1 3.62 last 30 days). If a fourth starter is needed the Dodgers will look to former Cub Greg Maddux or bring back Lowe on short rest. Rookie Phenom Clayton Kershaw will make the move to the bullpen, adding a third left handed arm to a very strong unit.
The Bullpen is anchored by Takashi Saito, perhaps one of the most underrated closers in the game. Setting up Saito are hard throwing youngsters Hong-Chi Kuo and Jonathan Broxton, who both feature fastballs in the upper 90's. Lefty specialist Joe Beimel has been very effective this year, but doesn't figure to get a whole lot of work against the predominately right handed hitting cubs.
About the Cubs
The Cubs come into the series with the best record in the National league (97-64). While the Dodgers were scrapping for their playoff lives, Chicago was able to cruise into the playoffs, resting some regulars and getting good looks at some younger players. The Cubs made a big splash trading for oft-injured Rich Harden but passed on some other possible moves, comfortable with what they had. The mostly right handed hitting lineup will be facing three right handed starters right out of the gate, so the early season pickup of Jim Edmonds could play a major part in the series. The Cubs picked Edmonds up off the scrap heap, after being discarded by last place San Diego, but Edmonds may have found the fountain of youth in Chicago. Since joining the Cubs, Edmonds has hit .256 with 19 home runs. After a stellar September in 2007, Geovany Soto has emerged as the steadying force for the Cubs. The MVP candidate and shoe in Rookie of the Year hit .285 with 23 HRs and has been amazing behind the plate.
The hottest hitter for the Cubs over the last month has been Mike Fontenot (.366 .909ops). Fontenot, who hasn't been an every day starter, could play a big part against the right handed pitching of the Dodgers, especially if Mark DeRosa's let calf is still acting up. DeRosa, perhaps one of the most underrated players in the game, injured the calf last week and has been sitting out since the 24th. For the Cubs to make a deep postseason run they are going to need production from the heart of the lineup. Aramis Ramirez has hit .342 over the last 30 days, but only hit 3 home runs in that same time frame. Derek Lee, who has had an overall disappointing season by his standards, is hitting just .273 with 2 home runs over the last 30 days. Probably most disappointing towards the end of the season, Alfonso Soriano is hitting just .243 over the last month, with 21 strikeouts in 82 at bats.
The Cubs pitching will probably be the biggest wild card in this series. When healthy, their staff would set up great for the post season. Unfortunately, Zambrano and Harden have had some nagging arm issues, forcing them to miss a few starts down the stretch. Zambrano followed up a no hitter on September 14 with two terrible starts, giving up 13 runs over 6 1/3 innings. Harden says he feels fine, but hasn't been showing his normal mid 90's fastball over the last few weeks, instead sitting around 88-89. Harden also has 16 walks over his last 4 starts (22 innings) and when you get into post season, where every run counts, that could come back to bite you. The Cubs have already decided on a four man rotation for the first series. They will start with Ryan Dempster (17-6, 2.99 ERA) who has been solid all year in his first year back as a starter after spending the last few years in the bullpen. Game two and three will go to Zambrano and Harden, and Ted Lilly (17-9 4.09ERA) will follow in game four if necessary.
The Cubs bullpen will likely play a huge role in the series. Pinella is going to carry 11 pitchers for the postseason, likely meaning the end of the year for Bob Howry. Kerry Wood (34-40Sv 3.26ERA) and Carlos Marmol (82app 2.68ERA 114K's) have been nothing short of solid at the end of games. Fifth starter Jason Marquis will likely get the spot as the long man out of the pen. Pinella has already stated that rookie Jeff Samardzija has earned a spot on the postseason roster, despite a few late season struggles. Lefties Sean Marshall and Neil Cotts will likely make the first round roster and the last spot will come down to Bob Howry and Chad Gaudin. If Gaudin is healthy enough to go then he should get the spot.
Key Players and Pitchers
Chicago Cubs
Key Player – Jim Edmonds - One of few left handed bats against mostly right handed pitching. The Cubs have had a power outage lately and will need Edmonds to get hot and stay hot.
Key Pitcher – Jeff Samardzija - With the iffy status of Zambrano and Harden the bullpen will be VERY important this week, especially in the middle innings. The Cubs will need some big innings from Samardzija in tight games.
Los Angeles Dodgers
Key Player – Andre Ethier – Everyone knows that Manny Ramirez has been on fire since joining the Blue, especially Pinella. The Cubs will do everything they can to make sure ManRam doesn't beat him, making Ethier's performance even more important.
Key Pitcher – Derek Lowe – The Dodgers need Lowe to be the playoff pitcher he was for the Red Sox. They will need him to come out and dominate hitters at Wrigley and take a lead in the series and may need him to throw the deciding game, something he should be used to by now.
Game Preview and Predictions
Game One - Lowe vs. Dempster in Chicago 5:30 PM
Derek Lowe is a postseason stud and I think he will continue his postseason dominance here in game one. The Dodgers will come out playing small ball against Dempster and the Cubs, knowing it won't take many runs to get the win. Lowe goes 8 and gets the win, but knocking him out of consideration for game 4. Dodgers win 3-1.
Game Two – Billingsly vs. Zambrano in Chicago 8:30 PM
This game has a ton of wild cards in it. How healthy is Zambrano? How will the young Billingsly respond to a postseason road game? Pinella won't stick with Zambrano long if he gets a bad vibe for Big Z's command. I think the pressure of the big game game will get to Billingsly a bit, as well as the Cubs bats. Cubs win 6-4.
Game Three – Harden vs. Kuroda in Los Angeles 9:00 PM
Kuroda threw a great game when the Dodgers shut out the Cubs in June and I believe he will pick up right where he left off. The Dodgers get to Harden early by being patient, drawing walks, and feasting on mistakes made in the zone. Dodgers win 5-2.
Game Four – Lilly vs. Maddux in Los Angeles TBD
One of the many curses bestowed upon the Cubs is former Cubs coming back to bite them. Unfortunately for Cubs fans, this one continues that trend. Both teams go to the bullpen early and the Dodgers win a wild one, 7-5.
Last edited by cybsball20; 09-29-2008 at 10:56 AM.
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I'll be posting my other previews as I finish them up... Brewers - Phillies later today and AL tomorrow.
I like the way this one turns out.
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Nice write up. The more I study at this series, the more formidable the Dodgers look. After the additions of Manny and Blake, they have a few more guys with a proven track record of post season success.
I don't like the prediction, but it seems like it could be very accurate.
Originally Posted by carvers4math
I need someone to rep Linden for me from another thread, he's a boss.
Originally Posted by CycloneRulzzz
Nice close in the troll thread Linden. You are the Mariano Rivera of CF. We just hit Enter Sandman and Linden comes in takes care of business.
I'm gonna get me a Dodger dog and wait for the next round. This looks over to me.
Pitching is going to be a big key in this series. I actually think coming in Lilly has been the best in the rotation recently and Dempster is tough at home so starting him game 1 makes sense. Dodger stadium is also a pitcher's ballpark so hopefully that helps the pen out in game 3 and 4 if necessary. I really hope Howry is left off, I'd even take Wuertz or Guzman over him right now but I have a feeling Lou is going with him for his veteran expirience but will only use him in non-critical spots.
Go Cubs Go!
And don't forget, the competition that the Dodgers have faced recently have been less then stellar. They have played 3 games with a team with a winning record in September, a far cry from who the Cubs had to face. And despite the fact that Harden's velocity may be down, he has still been very effective. Cubs in 4.
cysball20-That's a lot of work and a great analysis (I also like the outcome). I believe the Dodgers just decided to leave Kuo off the roster, though he hasn't pitched much lately anyway and Kershaw should fill that role. This should be a great series and game one will be huge. The Dodgers with Lowe need to take away the home field advantage from the Cubs. It will put a lot of pressure on Bills in game 2 if they don't.
Originally Posted by travman23
Pitching is going to be a big key in this series. I actually think coming in Lilly has been the best in the rotation recently and Dempster is tough at home so starting him game 1 makes sense. Dodger stadium is also a pitcher's ballpark so hopefully that helps the pen out in game 3 and 4 if necessary. I really hope Howry is left off, I'd even take Wuertz or Guzman over him right now but I have a feeling Lou is going with him for his veteran expirience but will only use him in non-critical spots.
Just heard now from a good source that it might be Cotts as the odd man out with Howry and Gaudin in...
Originally Posted by CYKOFAN
cysball20-That's a lot of work and a great analysis (I also like the outcome). I believe the Dodgers just decided to leave Kuo off the roster, though he hasn't pitched much lately anyway and Kershaw should fill that role. This should be a great series and game one will be huge. The Dodgers with Lowe need to take away the home field advantage from the Cubs. It will put a lot of pressure on Bills in game 2 if they don't.
That would make sense, especially in round 1 with the right handed heavy lineup the Cubs bring. IF they were to face the Phils in the NLCS you would probably see him back.
The Cubs played in a playoff type atmoshpere yesterday at Milwaukee. Let's hope the 3 and out last year still stings a little.
I just bought two tickets to game two on Ebay!!!
I'm so pumped for this. My fourth time at Wrigley this year and my first Playoff game ever!!!
I removed it.
Originally Posted by rworkman83
I just bought two tickets to game two on Ebay!!!
I'm so pumped for this. My fourth time at Wrigley this year and my first Playoff game ever!!!
I will be at game 2. I was lucky enough to win the opportunity to buy facevalue tickets on cubs.com. Having a game at 8:30 at Wrigley is going to be a great atmosphere!
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Widespread Adoption of Biomarkers Has Been...
Peptide Drugs Are Not Only Diverse...
Scientific Misconduct Is Jeopardizing the Quality...
Constant Innovation and Translation of Scientific...
An international team of scientists today reports that they have successfully short-circuited immune responses that attack pancreatic insulin-producing cells, presenting a novel approach to treating type 1 diabetes (T1D). Their "reverse vaccine," a plasmid engineered to turn off gene sequences that stimulate the immune system and switch on gene sequences that suppress it, could help T1D patients preserve these cells and help treat this autoimmune disease, the scientists suggest today in Science Translational Medicine.
T1D is an autoimmune disease in which the immune system attacks insulin-producing pancreatic beta cells and requires lifelong treatment with multiple daily insulin injections. This autoimmune response is in part mediated by CD8+ T cells against various islet cell antigens including preproinsulin (PPI), the molecular precursor to insulin and islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). These cells have been detected in the blood and in the pancreatic islets of individuals with T1D.
Lead author Bart O. Roep, M.D., Ph.D., of the University of Leiden along with his colleagues elsewhere noted that therapy for T1D that targets the specific autoimmune response in this disease while leaving the remainder of the immune system intact, has long been a goal of diabetes researchers.
For this study, the investigators said they attempted to modulate, in an antigen-specific manner, the adaptive immune response to proinsulin with an engineered DNA vaccine encoding proinsulin. The vaccine was engineered to reduce the immunogenicity of the encoded proinsulin by substituting CpG hexameric motifs, which stimulate the innate immune response, with GpG hexameric nucleotide sequences, known to modulate innate immunity.
The investigators tested the effects of the vaccine in 80 subjects over 18 years of age who had been diagnosed with T1D within the past five years. Patients were randomized to receive intramuscular injections of BHT-3021 or BHT-placebo weekly for 12 weeks, and then monitored for safety and immune responses in a blinded fashion.
Results of the study demonstrated that an engineered plasmid that expresses proinsulin could preserve B cell function in T1D patients. In patients, C-peptide, a marker of b cell function, rose, and as the peptide increased, a deletion of CD8+T cells reactive to proinsulin, with no effect on other antigen-specific T cell responses, also occurred. No serious side effects among patients treated with the DNA vaccine were observed, the researchers report.
The findings indicate that by targeting the root cause of T1D, reverse vaccination could potentially change the course of events that lead to severe disease, and that the approach may also be helpful for treating other autoimmune diseases.
"This is the first demonstration of a DNA vaccine targeting type 1 diabetes in humans," said Richard Insel, M.D., chief scientific officer of JDRF, formerly known as the Juvenile Diabetes Research Foundation.
"Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8+ T cells in type 1 diabetes" was published online in Science Translational Medicine June 26.
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Rated 5 out of 5 by 4 reviewers.
Rated 5 out of 5 by Debl07 Great Red Wine I have tried 14 Hands Merlot and Cabs and saw this at World Market. Bought on sale (a steal) for an outdoor dinner with friends. Everyone enjoyed it and it is as good as their Merlot and Cab. Smooth with subtle tannin, berry background. Little sips with a swirl in the mouth yields a long lasting appreciation without having to overdo it. July 11, 2013
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