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Find out what crisis Leah is dealing with now. (OK! Magazine) Laura Michelle drops her music video for her song "Chuck Norris." (OK! Magazine) Secrets of… READ ON
Los Angeles singer-songwriter Laura Michelle just released her musical knockout blow, Chuck Norris, a whimsical pop anthem about unleashing the kung-fu master that lies within us all, exclusively with Radar.… READ ON
In a much meme-ed line from 2008's The Dark Knight, Harvey Dent mused that "you either die a hero, or you live long enough to become the villain." It's a bleak observation that's as true in the real world as it is in a Christopher Nolan hellscape. Show More Summary
Even though he is still being held without bail, Troy Ave returns with a new record called "Chuck Norris". Listen below.
In the wake of the Irving Plaza shooting, Troy Ave drops new song, 'Chuck Norris.' Continue reading…
Categories: Friday Rant, Services and Indirect Spend, Services Procurement & Contingent Labor, Services Procurement & Contingent Labor Management, Technology Tags: Incendiary Tidbits, L1 The application programming interface (API) has become an ubiquitous topic in the discussion of procurement and supply chain technology. Show More Summary
(June 1, 2016 01:37 PM, by Emily Skarbek) Irina Nistor has one of the most famous voices in Romania. While working as a translator of censored television programs in Romania under the Communist regime, she secretly dubbed over 3,000 banned movie titles on VHS tapes smuggled in... (0 COMMENTS)
Not a lot of people in today's America understand the Cloward-Piven strategy well enough to be as afraid of it as they should. Luckily, Chuck Norris is here to fill
Soon after martial arts legend and Hollywood film star Chuck Norris, 76, came out as a chemtrail conspiracy theory believer and accused the authorities of secretly spraying chemicals on unsuspecting masses as part of alleged global geoengineering...Show More Summary
Every day, the ProgrammableWeb team is busy, updating its three primary directories for APIs, clients (language-specific libraries or SDKs for consuming or providing APIs), and source code samples.
Actor and activist Chuck Norris may be considered one of the most popular action stars of his time, but people are once again talking about him for his new advocacy. Norris, 76, recently wrote an article at World Net Daily to talk about conspiracies surrounding chemtrails and the U.S. Show More Summary
Chuck Norris gets spiritual. In this interview, he reveals the many struggles he has endured that have brought him closer and made his faith stronger in the big guy upstairs…
It started as a joke about Sen. Mike Lee (R-Utah). "Kids wear Superman Pajamas. Superman wears Chuck Norris Pajamas. And Chuck Norris wears Mike Lee pajamas!" -Ted Cruz — Brady Jugler (@bradyjugler) April 26, 2014 In Iowa, the joke took on a new image. Suddenly, it was Rep. Steve King's picture on the pajamas, a token […]
With A History Of Violence, Tom Breihan picks the most important action movie of every year, starting with the genre's birth and moving right up to whatever Vin Diesel's doing this very minute. The Way Of The Dragon (1972) You couldShow More Summary
I think this is a great idea. I know having pets for myself is terrific therapy. I have no doubt that a military veteran would benefit from having a canine
What can we expect out of a Hillary Clinton presidency? Chuck Norris digs into Hillary's past, and what he finds, you won't like. Most people think that the two most
Director Mike Norris, son of Chuck Norris, Issues Call To Fearful Angry Meatheads To Stay Mad Even Though The Scary Black Man Will Soon Leave The White House Oh, sorry, that's my translation. Here it is in the original American. Director Mike Norris, son of Chuck Norris, Issues Call To Action To Protect America's Freedom […]
Chuck Norris is saving his might for the general election. It appeared that the roundhouse-kicking action star had thrown in with GOP candidate Sen. Ted Cruz of Texas when Norris's name appeared as a star attraction at a March 13 Cruz rally in Concord, N.C. The "Walker, Texas Ranger" actor had been a staunch supporter of Mike […]
Figures. The Cruz Camp lied. Chuck Norris did not endorse Ted Cruz. From the Chuck Norris Facebook page: There's false... The post Figures. Cruz Camp Lied: Chuck Norris Did Not Endorse Ted Cruz, Won't Campaign With Him appeared first on The Gateway Pundit.
On Tuesday, I reported that actor Chuck Norris would be joining Ted Cruz on the campaign trail and would presumably be endorsing the candidate....


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A new generation of innovative capital providers has ushered in a Golden Age of financing for small businesses. Today's entrepreneurs can select a finance provider, choose an application process that meets their needs, and specify a repayment schedule.
Read Whole Story
Dogs can dine at this top Paris restaurant, but bankers? Non!
It doesn't matter how much cash they have to splash, owner Alexandre Callet is not letti...
As the peak of the holiday season approaches, many small businesses will be seeking an injection of capital. This is a busy time for many business owners who need to account for an increase in sales.
This burden has left the U.S. female graduate with over $28,000 in student loan debt, according to The Institute for College Data and Statistics. Moreover, a new report from the Brookings Institution points out that this student debt average is quadruple the amount that it was just 12 years ago.
Many small business owners begin their search for capital by seeking out financing options. However, they might be skipping an important step: knowing their business' credit score.
Let's face it: many alternative small business lenders, funders and brokers have developed a bad reputation. Widely used labels such as "dishonest" and "predatory" are putting the industry at risk.
First, understand that the main reason you're being asked to cosign a loan is because lenders don't think the borrower is a good risk. By cosigning, you're guaranteeing that you'll repay the full loan -- plus any late fees or collection costs -- should the borrower default.
It's been six months since Typhoon Haiyan, one of the most powerful typhoons ever recorded, tore through the Philippines and displaced 4 million people.
We already knew this debt was harming the economy by undercutting young graduates' ability to buy homes and cars, hampering consumer demand in two key sectors of the economy.
Merchants basically get it -- to many of them, Groupon looks less like an innovative advertising mechanism than a loan broker, arranging bundles of small loans from consumers, and taking a substantial cut... Consumers don't often see this side of the equation.
The FHA operates as a mortgage insurance program. It promises to cover lender losses if a loan goes bad. Like any insurance program it collects premiums, keeps reserves and pays out claims.
For the past year there have been worries that the FHA might require taxpayer money to pay off lender claims for loans gone bad. But now it may be that the economy has turned around and the FHA may well do better than anyone thinks.
For months the real estate industry has been complaining about a shortage of homes to sell, an inventory which is too small. Raise down payment requirements and the inventory problem will vanish while home prices will fall. Why? Because there will be fewer buyers in the market looking for homes.
If your company recently applied for business credit and was rejected, it's not alone.
Karen Sposato is one of the lucky homeowners in Breezy Point, N.Y., a community ravaged by Hurricane Sandy and the devastating fires that followed -- ...
If you recently have had a hard time getting a loan, you're not alone.
Since 2007, most banks have become too skittish to lend to people with less-...
When Gerard Massey covers the bill at a local pizza parlor in Tallahassee, Fla., he tells his friends who owe him money straight-up: Debit or credit o...
In this tough economic market everyone wants to save money, especially home sellers. A home seller may want to consider or even actually venture into ...
Where do you go for a $10,000 loan when you have bad credit? Don't try a storefront lender. Some are closing their doors. Folks with spotty credit his...
The only thing stopping banks from putting your Facebook page into your credit file is the law. But even that line is growing blurrier.
One new ba...
Medicaid is vital -- it provides hundreds of millions of children who are poor or have disabilities with comprehensive health coverage enabling them to become productive, taxpaying members of society.
In a destitute country facing famine, natural disasters, and a beleaguered government, Muhammad Yunus saw an opportunity to help people one by one, and built an organization of others helping poor people help themselves
By Michelle Conlin Jan 25 (Reuters) - In July 2009, Roy and Sheila Bowers refinanced the mortgage on their suburban ranch home in Tope...
Some couples stay together for love, and others stay together for the kids. But today, with unemployment at 9.1% and real estate prices continuing to...
If you are one of those seriously delinquent homeowners, or one who is draining your nest egg or tapping home equity to make the mortgage payments, is there a way to hang on long enough?
Get top stories and blog posts emailed to me each day. Newsletters may offer personalized content or advertisements. Learn more.


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Writer: Robbie Lee
Date:Saturday September 6 2008
Time: 12:32PM
St James Park
Saturday 6 September 2008
Despite heavy rain in the week, Exeter City's League Two clash with Accrington Stanley is certain to go ahead.
City go into the game having lost four games at home this season, and, despite a moderately pleasing return of four points from four games, will be viewing this as a must-win fixture.
Paul Tisdale told the Express & Echo: 'I expect a very good game and it is more about us than them.'
'I haven't seem them play before but I have had a couple of reports.
'We haven't quite found our winning formula yet this season and that is what the focus is on more than worrying about Accrington.
'We will get better and better and we have just got to keep the faith. Passing and creative football comes off the back of confidence and we must make sure we keep that.
'We want to win every game we play and it is very important that we get what we deserve.
'If we had only deserved four points so far then we would have a different attitude, but we deserve more than that.'
With left back George Friend sold to Wolves, Dean Moxey will take his place at left back.
Craig McAllister will be available for the last time before a three match ban courtesy of a sending-off in a reserve game at Plymouth.
The lad's got a big big job to do filling George's boots.
Accrington will be without injured keeper Ian Dunbavin.
And here's why. Over 40,000 people have now watched this link.
Stanley have won four of their five games at City - two in the Conference, one in the Fourth Division and one in the F.A Cup.
However, City have never lost at Accrington Stanley, with three wins and a draw at Lancashire.
The last City player to score against Accrington was Jake Edwards, in a 3-1 defeat live on Sky.
It could be high scoring. We'll say 3-2 to City.
Date:Saturday September 6 2008
Time: 12:32PM
League Cup Draw Wednesday 1pm (Tuesday June 21 2016)
League Two Fixtures For 2016/17 Released Tomorrow (Tuesday June 21 2016)
Exeter Fans To Travel 9,805 Miles In 2016/17 (Friday June 17 2016)
Football League - Fixture Day & 2016/17 Key Dates (Wednesday June 15 2016)
Average League Position In Last 50 Yrs (Monday June 13 2016)
U21 Teams Welcomed To The FL Trophy (Saturday June 11 2016)
Premier League & Championship Free Agents 2016 (Friday June 10 2016)
2016/17 Fixtures Are A Hoax - Football League (Tuesday June 7 2016)
72 FL Stats - Which Is Exeter's For 2015/16 (Friday June 3 2016)
Tisdale In Top Ten Manager List - 2015/16 (Tuesday May 31 2016)
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Basics of Brush Hand Lettering with Spectrum Noir Aqua Markers
Today I am really excited to share a few tips and tricks about brush hand lettering, which is one of my favorite creative outlets. I am not a professional letterer by any stretch of the imagination, but I have spent some time over the past years learning and practicing my techniques. I have really enjoyed my […]
Canvas Art Idea: Watercolor Canvas Magnets
While I love LOVE my craft room, I'm finding that I'm struggling – big time – in the organizational department. I've got notebooks full of ideas, planners listed with lots of different dates, and kids artwork and projects in progress taped up all over the walls. I've finally broken down and began the arduous process […]
Foiled Canvas DIY Beach Bag
I love creating personalized beach bags for myself, my family and friends. This time I decided to hand-letter my own design and convert it into an iron-on for this year's DIY beach bag. I've been looking forever for foiled heat transfer as well, but I have yet to find any inexpensive alternative, so I tried […]
Make Your Own DIY Beach Fairy Garden
There are two things I'm absolutely crazy about right now, fairy gardens and anything related to the beach. I decided to mix the two of them into one awesome DIY beach fairy garden tutorial that's fun for an adult to make but easy enough for kids as well! Supplies needed to make your own DIY […]
Nautical DIY Flag Garland
I am absolutely crazy about all the nautical decor I've been seeing everywhere lately. From driftwood to weathered oars, nothing says "summer" quite like nautical decor! Whether you're planning a Bon Voyage party or looking for decorations for your beach house (I wish!), this nautical DIY flag garland is tons of fun to make! Supplies needed […]
Glass Etching Tutorial: Nautical Etched Votives
I'm loving everything nautical in my home decor and I wanted to create some custom decor accents using etching cream. Have you ever been interested in learning how to custom etch? Etching is quite simple and with the right tools you can create fun custom glass creations like these nautical etched votives. Today I'm going […]
DIY Lighthouse Garden Craft
Learn how to make this garden DIY lighthouse for your outdoor decor. This quick and easy project can be made in any colors that you choose for a fun addition to your flower bed or porch. You can also light up the night with a few of these lighthouses around your sidewalk! Supplies needed to […]
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Fax: (713) 745-1163
Original Article
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma†
Version of Record online: 29 AUG 2008
DOI: 10.1002/cncr.23822
Copyright © 2008 American Cancer Society
Volume 113, Issue 8, pages 2038–2045, 15 October 2008
Additional Information
How to Cite
Overman, M. J., Kopetz, S., Wen, S., Hoff, P. M., Fogelman, D., Morris, J., Abbruzzese, J. L., Ajani, J. A. and Wolff, R. A. (2008), Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. Cancer, 113: 2038–2045. doi: 10.1002/cncr.23822
- †
Presented at the American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium, Orlando, Florida, January 19-21, 2007 [abstract 172]. This article contains original work not previously published.
Publication History
- Issue online: 3 OCT 2008
- Version of Record online: 29 AUG 2008
- Manuscript Accepted: 9 JUN 2008
- Manuscript Revised: 6 JUN 2008
- Manuscript Received: 18 APR 2008
- Abstract
- Article
- References
- Cited By
- small bowel adenocarcinoma;
- chemotherapy;
- platinum;
- fluorouracil;
- metastasis;
- survival
Metastatic small bowel adenocarcinoma (SBA) has a poor prognosis. Because of the rarity of SBA, only a few studies have evaluated the role of chemotherapy in the treatment of metastatic SBA; thus, the benefit, if any, of adding a platinum compound to fluorouracil (5-FU) is unknown. The objective of this retrospective study was to determine whether the addition of a platinum compound to 5-FU provided any benefit in the treatment of patients with metastatic SBA.
The authors identified 80 patients with metastatic SBA who were treated with chemotherapy at the University of Texas M. D. Anderson Cancer Center between 1978 and 2005. Response rates, progression-free survival (PFS), and overall survival (OS) were compared between patients who received 5-FU and a platinum compound and patients who received other chemotherapy combinations.
The median patient age was 53 years. The primary tumor site was the jejunum in 35 patients (43%), duodenum in 30 patients (38%), ileum in 6 patients (8%), and nonspecified small bowel in 9 patients (11%). Of all 80 patients, 29 patients (36%) received 5-FU and a platinum compound, 41 patients (51%) received 5-FU without a platinum compound, and 10 patients (13%) received non-5-FU–based treatment. Compared with other chemotherapy regimens, treatment with 5-FU and a platinum agent resulted in a higher response rate (46% vs 16% with other regimens; P = .01) and longer median PFS (8.7 months vs 3.9 months; P ≤ .01) but not better OS (14.8 months vs 12 months; P = .1). In multivariate analysis, treatment with 5-FU and a platinum compound was a significant predictor of response (odds ratio, 4.5; 95% confidence interval [CI], 1.3-15.8; P = .02) and PFS (hazard ratio. 0.49; 95% CI, 0.29-0.84; P = .01) but only reached borderline significance for OS (hazard ratio, 0.63; 95% CI, 0.37-1.07; P = .08).
To the authors' knowledge, the current analysis represents the largest number of patients with metastatic SBA treated with chemotherapy in the literature, and the results suggested that the combination of 5-FU and a platinum compound leads to a higher response rate and PFS compared with other chemotherapy regimes. The authors concluded that prospective investigation of platinum analogues in the treatment of SBA is warranted. Cancer 2008. © 2008 American Cancer Society.
Small bowel adenocarcinoma (SBA) is an aggressive neoplasm with a poor prognosis. Although it is rare, with an estimated annual incidence in the United States of about 2400, SBA is the most common histologic subtype of small intestinal cancer.1–3 Because of the difficulties in diagnosing SBA, the majority of patients with SBA are not treated until the disease has reached an advanced stage. The outlook for patients with advanced SBA is poor: According to the National Cancer Data Base, the 5-year overall survival (OS) rates for patients with stage III or stage IV SBA are 35% and 4%, respectively.4
Because of the rarity of SBA, no randomized trials have evaluated the role of chemotherapy in this disease. Recently, retrospective studies have demonstrated that treating advanced SBA patients with palliative chemotherapy has a survival benefit compared with patients who do not receive palliative chemotherapy.5–7 In a retrospective study conducted by the British Columbia Cancer Agency, patients with locally advanced or metastatic SBA who received 5-fluorouracil (5-FU)-based chemotherapy had a longer median OS (15.6 months) than patients who received no chemotherapy (7.7 months).5 Another retrospective study demonstrated that chemotherapy for patients with inoperable or metastatic SBA resulted in an improved median OS (12 months) compared with no chemotherapy (2 months).6
The choice of chemotherapy has not been studied well for the treatment of SBA. A summary of studies that evaluated various chemotherapy combinations in the treatment of metastatic SBA is provided in Table 1. In 1965, Rochlin et al reported the first retrospective study to evaluate the role of systemic chemotherapy for metastatic SBA. In their study, 11 patients with SBA who had been treated at the University of California-Los Angeles Medical Center had a 36% response rate (RR) to single-agent fluorouracil (5-FU) treatment.8 Other retrospective studies have reported RRs for 5-FU–based treatment ranging from 5% to 18%.5, 9, 10 In 2005, the Eastern Cooperative Group conducted the largest prospective study of chemotherapy for SBA; 38 patients with SBA received 5-FU, doxorubicin, and mitomycin C and demonstrated an 18% RR and a median survival of 8 months.9
|Study Type
|No. of Patients
|OS, mo
|Overman 200822
|Phase 2
|Fishman 20067
|Various agents
|Locher 200514
|5-FU and platinum
|Gibson 20059
|Phase 2
|Enzinger 200523
|Phase 1
|5-FU, cisplatin, irinotecan
|Czaykowski 20045
|5-FU based
|Goetz 200324
|Phase 1
|5-FU, oxaliplatin, irinotecan
|Crawley 199813
|Jigyasu 198410
|Morgan & Busuttil 197725
|Rochlin 19658
The benefit observed from the addition of a platinum chemotherapy agent to 5-FU–based chemotherapy in both colon adenocarcinoma and gastric adenocarcinoma has suggested a possible role for this kind of chemotherapy in the treatment of SBA.11, 12 Researchers at the Royal Marsden Hospital reported a 37% RR and a median OS of 13 months for 8 patients with SBA who were treated with epirubicin, cisplatin, and 5-FU.13 A second retrospective study by Fishman et al from the Princess Margaret Hospital reported an RR of 23% for 11 patients who received platinum-based therapy.7 Another retrospective study reported a 21% RR for 20 patients with advanced SBA who were treated with a combination of 5-FU and a platinum agent.14 In an interim analysis of 21 patients from a phase 2 study of capecitabine plus oxaliplatin in the treatment of adenocarcinoma of the small bowel and the ampulla of Vater, we observed an RR of 52% and a median OS of 16.3 months.15 To clarify the optimal chemotherapy for patients with metastatic SBA, we undertook this retrospective study to determine the benefit, if any, of adding a platinum agent to 5-FU.
Patients and Data Collection
We identified all patients from the M. D. Anderson Tumor Registry who were treated for metastatic SBA at the M. D. Anderson Cancer Center (M. D. Anderson) between 1978 and 2005. In total, 177 patients with metastatic SBA were identified, and 80 patients who met the following criteria were included in this report. Patients were required to have tumor histology that was reviewed at M. D. Anderson and was consistent with SBA. Only patients who were undergoing first-line chemotherapy for metastatic disease and who received ≥1 cycle of chemotherapy were included. Documentation of metastatic disease, either radiographically or at the time of surgery, was required. Patients had to have undergone a radiologic assessment of tumor response after the administration of chemotherapy. Six patients who had documented peritoneal involvement at surgery but did not have radiographically measurable disease were included in the study but were excluded from the univariate and multivariate analyses for treatment response. Chemotherapy treatment in these 6 patients consisted of 5-FU (3 patients), 5-FU and carboplatin (1 patient), 5-FU and cisplatin (1 patient), and 5-FU and oxaliplatin (1 patient). Patients who had tumors that involved the ampulla of Vater were excluded. Patients who were enrolled in an ongoing, prospective, phase 2 study of capecitabine and oxaliplatin for SBA were not included in this study.
Patient medical records were reviewed for information regarding demographic data, tumor characteristics, treatment types, treatment responses, and survival. Because of the long period covered by the study and because not all radiologic images were available for our review, response evaluation was based on the treating physician's response assessment. Tumor stage was determined according to the American Joint Committee on Cancer staging system.16 Histologic grading was determined according to the World Health Organization standard grading system: poorly differentiated, moderately differentiated, well differentiated, or undifferentiated. According to this system, tumors with 2 different degrees of histiologic differentiation are recorded as having the lesser grade. This analysis was approved by the M. D. Anderson Institutional Review Board.
Statistical Analysis
We created descriptive summaries for each demographic and clinical variable. The following variables were examined in univariate and multivariate analyses for RR, progression-free survival (PFS), and OS: age, sex, histologic grade, primary site, stage at presentation, initial site of metastasis, surgery for primary tumor, prior adjuvant chemotherapy, and use of platinum-based or 5-FU–based chemotherapy for metastatic disease.
The Fisher exact test was used to assess the independence between 2 categorical variables. Survival curves were calculated from the start of chemotherapy using the Kaplan-Meier method. The 2-sided log-rank test was used to test the association between variables and OS and PFS. In the multivariate analysis, a Cox proportional hazards model was used to assess the simultaneous effect of ≥2 variables on OS and PFS. To compensate for advances in supportive care, radiation therapy techniques, and surgical techniques over the period studied, we included chronological time as a covariate in all multivariate modeling. To obtain the best subset of variables in the final model, we performed stepwise model selection. P values were derived from 2-sided tests, and the statistical analyses were carried out using S-PLUS 2000 software (MathSoft, Inc., Seattle, Wash).
Patient Characteristics
Table 2 shows the clinical characteristics of the 80 patients who met our study's inclusion criteria. The median age was 53 years (range, 23-76 years), and 59 patients (74%) initially presented with stage IV disease. Of the 59 patients who presented with metastatic disease, 34 patients (58%) underwent surgical resection of their primary tumor, 11 patients (19%) underwent a surgical bypass, and 14 patients (23%) underwent a biopsy. The liver and the peritoneum were the most common initial sites of metastatic disease. Elevations in carcinoembryonic antigen (CEA) were not observed commonly, and only 31% of patients had a CEA level >10 mg/dL.
|No. (%) of Patients
|Age, y*
|43 (54)
|37 (46)
|68 (85)
|6 (7)
|6 (7)
|Initial stage
|21 (26)
|59 (74)
|Primary tumor site
|30 (38)
|35 (43)
|6 (8)
|Small bowel NOS
|9 (11)
|Histologic grade
|Well differentiated
|5 (6)
|Moderately differentiated
|46 (58)
|Poorly differentiated
|17 (21)
|Adenocarcinoma NOS
|12 (15)
|Mucinous histology
|12 (15)
|Initial sites of distant metastasis
|37 (46)
|37 (46)
|Distant lymph nodes
|7 (9)
|6 (8)
|6 (8)
|Primary tumor resected
|55 (69)
|Primary resected (stage IV only)
|34 (58)
|Adjuvant chemotherapy
|8 (10)
|CEA >10 mg/dL
|16/52 (31)
The majority of patients had a primary tumor site within the jejunum (n = 35 patients; 44%) or the duodenum (n = 30 patients; 38%). Fifty-one patients (64%) had moderately or well differentiated SBA. Twelve patients (15%) had tumors with mucinous histologic features, and 8 of those patients had well to moderately differentiated tumors.
Of the 21 patients who initially presented with stage I, II, and III disease but subsequently developed metastatic disease, 8 patients received adjuvant chemotherapy, including 3 patients who received single-agent 5-FU therapy, 3 patients who received 5-FU and radiation, 1 patient who received 5-FU and mitomycin C, and 1 patient who received 5-FU and carboplatin. Of the 8 patients who received adjuvant chemotherapy, 7 patients (88%) had lymph node involvement, whereas only 3 of the 13 patients (23%) who did not receive adjuvant chemotherapy had lymph node involvement. The median time from completion of adjuvant therapy to development of metastatic disease was 7 months (range, 3-18 months). The chemotherapy administered to these 8 patients when they developed metastatic disease was irinotecan-based therapy in 2 patients, the combination of 5-FU and a platinum agent in 1 patient, and other 5-FU–based therapies in 5 patients.
First-line Chemotherapy Treatment and Response
Forty-one patients (51%) received 5-FU–based therapy without a platinum agent; 29 patients (36%) received 5-FU–based therapy with a platinum agent; 5 patients (6%) received non-5-FU–containing, platinum-based therapy; and 5 patients (6%) received a nonplatinum, non-5-FU–based therapy (Table 3). 5-FU was delivered intravenously in 53 patients (76%) and as the oral 5-FU prodrug, capecitabine, in 17 patients (24%). Capecitabine was administered either alone (1 patient), combined with cisplatin (9 patients), combined with oxaliplatin (6 patients), or combined with carboplatin and paclitaxel (1 patient). Of the 29 patients who received 5-FU and a platinum agent, 3 patients (10%) also received a third agent (paclitaxel in 1 patient, interferon-alpha in 1 patient, and bevacizumab in 1 patient). Irinotecan combinations were given to 2 patients, and a gemcitabine combination was given to 1 patient with no observed responses.
|No. (%) of Patients
|No. [& Response Rate]
|5-FU and no platinum
|41 (51)
|7 [17]
|5-FU alone
|5-FU and mitomycin-C
|Other 5-FU–based combinations*
|5-FU and platinum
|29 (36)
|12 [41]
|5-FU and cisplatin
|5-FU and carboplatin
|5-FU and oxaliplatin
|Non-5-FU–based treatment
|10 (13)
|1 [13]
|Platinum and no 5-FU†
|No platinum and no 5-FU‡
The overall RR for the 80 patients was 25%, with 19 partial responses and 1 complete response. The single complete response occurred in a patient who had duodenal adenocarcinoma with biopsy-proven peritoneal metastases. The patient had radiographic resolution of her disease after 6 months of capecitabine and cisplatin and was alive without evidence of recurrence 50 months after she completed chemotherapy. None of the 8 patients who had received prior adjuvant chemotherapy responded to chemotherapy for their metastatic disease.
Table 4 compares patients who received a platinum agent and those who did not receive a platinum agent. Platinum-based chemotherapy was given more commonly to patients who had primary tumors in the duodenum, initially presented with stage IV disease, or did not undergo resection of their primary tumor. Of the 74 patients who had metastatic disease that was measurable radiographically at the start of chemotherapy, the 26 patients who received 5-FU and a platinum agent had a higher RR (46%) compared with the 48 patients who received other chemotherapy combinations (16%; P = .01). Treatment with the combination of 5-FU and a platinum agent was the only significant predictor of response in both univariate and multivariate analyses (odds ratio, 4.5; 95% confidence interval, 1.3-15.8; P = .02). Patients who had metastatic duodenal adenocarcinoma had a slightly higher RR (34%) compared with patients who had metastatic disease form other small bowel sites (RR, 22%), but the difference was not significant (P = .29). Among the 26 patients who received 5-FU and a platinum agent, the primary tumor site did not correlate with response (RR: 47% for duodenal primaries, 44% for other small bowel sites).
|No. (%) of Patients
|No Platinum
|Median age, y
|16 (47)
|27 (59)
|18 (53)
|19 (41)
|Initial stage
|4 (12)
|17 (37)
|30 (88)
|29 (63)
|Primary site
|20 (59)
|10 (22)
|11 (32)
|24 (52)
|1 (3)
|5 (11)
|Small bowel NOS
|2 (6)
|7 (15)
|Histologic grade
|Well to moderately differentiated
|26 (76)
|25 (54)
|Poorly differentiated
|5 (15)
|12 (26)
|Adenocarcinoma NOS
|3 (9)
|9 (20)
|Initial sites of distant metastasis
|16 (47)
|21 (46)
|18 (53)
|19 (41)
|Primary tumor resected
|16 (47)
|39 (85)
|Adjuvant chemotherapy
|2 (6)
|6 (13)
Survival After First-line Chemotherapy Treatment
For the 80 patients who were included in this study, the median follow-up was 47 months, the median OS was 13 months (95% confidence interval, 10.4-16.5 months), and the median PFS was 4.6 months (95% confidence interval, 3.9-7 months). Patients who received 5-FU and a platinum agent had a higher median PFS (8.7 months) than patients who received other chemotherapy combinations (3.9 months; P = .003) (Fig. 1B). In the univariate analysis of PFS, treatment with 5-FU (P = .01) and treatment with a platinum agent (P = .02) were the only factors associated with improved PFS.
There was a trend toward a longer median OS in the patients who were treated with 5-FU and a platinum agent (14.8 months) compared with other patients (12 months), but the difference did not reach statistical significance (P = .1) (Table 5, Fig. 1B). In the univariate analysis of OS, both resection of the primary tumor (P = .01) and 5-FU treatment (P = .02) were associated with improved OS. In addition, patients whose grade of adenocarcinoma was not specified had a worse OS (P = .05); however, this subset of patients was small (n = 9). Resection of the primary tumor was also analyzed in the subgroup of patients who initially presented with stage IV disease. Undergoing primary tumor resection in this subgroup was associated with an improved median OS of 14.7 months compared with patients whose primary tumor remained intact (median OS, 10.4 months; P = .048).
|Median Survival, mo
|Age, y
|Histologic grade
|Poorly differentiated
|Well to moderately differentiated
|Adenocarcinoma NOS
|Mucinous histology
|Primary tumor site
|Small bowel NOS
|Adjuvant chemotherapy
|Primary tumor resected
|Peritoneal metastases
|Liver metastases
|5-FU chemotherapy
|Platinum chemotherapy
Table 6 shows the results of the multivariate analyses of potential predictors of PFS and OS. More recent chronological treatment and the lack of prior adjuvant chemotherapy both were predictors of longer PFS and OS. Treatment with 5-FU and a platinum agent was a significant predictor of PFS (P < .01) but did not reach statistical significance for OS (P = .08). Resection of the primary tumor was a significant predictor of OS (P = .019) but not PFS.
|Progression-free survival
|Chronological time
|Primary tumor resected
|Adjuvant chemotherapy
|Treatment with 5-FU and platinum
|Overall survival
|Chronological time
|Primary tumor resected
|Adjuvant chemotherapy
|Treatment with 5-FU and platinum
Second- and Third-line Chemotherapy
Fifty-seven chemotherapy treatments were administered as second- or third-line chemotherapy to 38 patients. Six patients (11%) responded to treatment, including 2 patients who responded to irinotecan-based therapy (n = 16 treated patients), 2 patients who responded to platinum-based therapy (n = 6 treated patients), 1 patient who responded to mitomycin C-based therapy (n = 9 treated patients), and 1 patient who responded to gemcitabine-based therapy (n = 2 treated patients). In general, all responses were of brief duration (<4 months).
In the current study, we observed that using 5-FU and a platinum agent to treat SBA resulted in a significantly improved RR (46% vs 16%), and PFS (8.7 months vs 3.9 months) compared with other chemotherapy combinations. Treatment with 5-FU and a platinum agent remained a significant predictor of response and PFS in our multivariate analyses. With regard to OS, the use of 5-FU and a platinum agent was not a significant predictor, although the value (P = .08) was suggestive of a possible relation. It is our opinion that the results of this study support the use of combination chemotherapy with 5-FU and platinum analogue for the treatment of metastatic SBA.
The factors associated with an improved OS in multivariate analysis were more recent chronological treatment, absence of prior adjuvant chemotherapy, and resection of the primary tumor. Of the 8 patients who received adjuvant 5-FU–based therapy, none responded to chemotherapy treatment for metastatic disease. Of those 8 patients, 5 patients were retreated with 5-FU-based nonplatinum and nonirinotecan therapy. It is also possible that the patients with localized disease who received adjuvant therapy had more aggressive tumor characteristics. Whether the lower OS observed in patients who previously received adjuvant 5-FU–based therapy was because of prior exposure to 5-FU or because of a selection bias is not known. Resection of the primary tumor was significant not only for the entire 80-patient cohort but also for the subset of patients who initially presented with stage IV disease. In this subgroup, patients who underwent resection of their primary tumor had an OS of 14.7 months compared with 10.4 months for patients who did not undergo surgical removal of the primary tumor. However, this result may be confounded by the presence of a greater burden of disease in those patients who did not undergo resection.
Previous studies conducted primarily in patients with localized SBA have suggested a worse outcome for patients with adenocarcinoma of the duodenum compared with to adenocarcinoma of the ileum or jejeunm.4, 6 In the current study, we observed no correlation between the primary tumor site and survival in patients with metastatic SBA. Although more patients with duodenal tumors were treated with a platinum agent, duodenal tumors did not respond better than nonduodenal small bowel tumors to platinum-based therapy.
The histologic grade of the tumor did not correlate with RR or PFS. Tumors that were classified as adenocarcinoma not otherwise specified demonstrated a worse OS than tumors with well, moderate, or poor differentiation. Only 9 patients had adenocarcinoma not otherwise specified, and those patients tended to be patients who had been treated in the earlier decades of this study. This result contrasts with other studies, in which poorly differentiated histology has been associated with a worse survival.7, 17, 18 The most common sites of metastases were the peritoneum and the liver, similar to prior reports.19, 20 Although peritoneal disease has been associated with worse outcomes for other gastrointestinal malignancies, we observed no difference in median OS between patients with and without peritoneal disease (15 months and 12.7 months, respectively).21
There is little information in the literature on the use of second- and third-line chemotherapy for SBA. Locher et al observed no radiographic responses to primarily irinotecan-based, second-line chemotherapy administered to 13 patients with SBA.14 Fishman et al observed responses to second-line chemotherapy in 4 of 18 patients, and 3 of their patients responded to gemcitabine-based therapy.7 In our study, a total of 57 chemotherapy treatments were given as either second-line or third-line therapy, and only 6 radiographic responses were observed (RR, 11%).
We acknowledge that our report has several limitations and that our findings are hypothesis-generating. Important limitations are 1) the retrospective nature of the report; 2) despite having a large denominator, interpretation of variables is limited by the many small subgroups of patients; and 3) heterogeneous therapy over a long time (partially compensated by incorporating chronological time as a covariate in our multivariate model). In addition, the young age of our patient population suggests a possible referral bias.
The infrequency of SBA has made it difficult to study. It is extremely unlikely that a randomized trial comparing 2 chemotherapy regimens will be conducted. However, a prospective phase 2 trial conducted within a cooperative group or outside a cooperative group (but in a multicenter setting) should be encouraged.
In the current study, we observed that treatment with 5-FU and a platinum agent was highly effective, producing an RR of 41% and a median PFS of 8.7 months. Patients who receive this combination may also gain an OS benefit. The combination of 5-FU and a platinum agent appears to be superior to other chemotherapy treatments, and this combination is recommended for the frontline treatment of patients with metastatic SBA.
- 1A population-based study of the incidence of malignant small bowel tumors: SEER, 1973-1990. Int J Epidemiol. 1996; 25: 722–728., , , .
- 2Incidence of histologic types of cancer of the small intestine. J Natl Cancer Inst. 1987; 78: 653–656., .
- 3Cancer statistics, 2006. CA Cancer J Clin. 2006; 56: 106–130., , , et al.
- 4The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the small bowel: review of the National Cancer Data Base, 1985-1995. Cancer. 1999; 86: 2693–2706., , , .
- 5Chemotherapy for small bowel adenocarcinoma (SBA): experience over a 10-year period at the BC Cancer Agency [abstract]. Presented at the American Society of Clinical Oncology 2004 Gastrointestinal Cancers Symposium, San Francisco, California, January 22-24, 2004. Abstract 109..
- 6Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer. 2004; 101: 518–526., , , , .
- 7Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases. Am J Clin Oncol. 2006; 29: 225–231., , , et al.
- 8Chemotherapy of malignancies of the gastrointestinal tract. Am J Surg. 1965; 109: 43–46., , .
- 9Phase II study of 5-fluorouracil, doxorubicin, and mitomycin C for metastatic small bowel adenocarcinoma. Oncologist. 2005; 10: 132–137., , , .
- 10Chemotherapy for primary adenocarcinoma of the small bowel. Cancer. 1984; 53: 23–25., , .
- 11Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000; 18: 2938–2947., , , et al.
- 12Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol. 1997; 15: 261–267., , , et al.
- 13The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil. Br J Cancer. 1998; 78: 508–510., , , , .
- 14Combination chemotherapy in advanced small bowel adenocarcinoma. Oncology. 2005; 69: 290–294., , , et al.
- 15A phase II study of capecitabine and oxaliplatin (CAPOX) in metastatic adenocarcinoma of the small bowel or ampulla of Vater [abstract]. Presented at the American Society of Clinical Oncology 2007 Gastrointestinal Cancers Symposium, Orlando, Florida, January 19-21, 2007. Abstract 139., , , et al.
- 16GreeneFL,PageDL,FlemingID, et al, eds. AJCC Cancer Staging Manual,6th ed. New York, NY: Springer-Verlag; 2002.
- 17Adenocarcinoma of the small bowel: a study of 37 cases with emphasis on histologic prognostic factors. Dis Colon Rectum. 2002; 45: 1496–1502., , , , .
- 18Smoking, alcohol use, dietary factors and risk of small intestinal adenocarcinoma. Int J Cancer. 1997; 70: 512–517., , .
- 19Adenocarcinoma of the small intestine: 21-year review of diagnosis, treatment, and prognosis. Ann Surg Oncol. 1994; 1: 183–188., , , , .
- 20Small bowel cancer: a 30-year review. Ann Surg Oncol. 1994; 1: 290–295., , .
- 21Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000; 88: 358–363., , , et al.
- 22Final response data of a phase II study of capecitabine and oxaliplatin (CAPOX) in advanced adenocarcinoma of the small bowel or ampulla of Vater [abstract]. J Clin Oncol. 2008; 26S. Abstract 4538., , , et al.
- 23Phase I dose-finding and pharmacologic study of cisplatin, irinotecan, and either capecitabine or infusional 5-FU in patients with advanced gastrointestinal malignancies [abstract]. Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium, Hollywood, Florida, January 27-29, 2005. Abstract 28., , , et al.
- 24Phase I and pharmacokinetic study of 2 different schedules of oxaliplatin, irinotecan, fluorouracil, and leucovorin in patients with solid tumors. J Clin Oncol. 2003; 21: 3761–3769., , , et al.
- 25Primary adenocarcinoma of the small intestine. Am J Surg. 1977; 134: 331–333., .


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|By Marketwired .
Article Rating:
|June 11, 2014 10:03 AM EDT
DALLAS, TX -- (Marketwired) -- 06/11/14 -- Masergy Communications Inc., a global leader in managed networking and cloud services, today announced its Intelligent Service Control (ISC) with global on-demand bandwidth and pre-scheduled calendaring options has been named as a finalist in the Light Reading 2014 Leading Lights awards program in the Most Innovative Enterprise Service category. The Leading Lights awards are the telecom industry's most prestigious awards program and focus on next-generation communications technologies, applications, services, and strategies.
Masergy's Intelligent Service Control (ISC) allows enterprise organizations to make real-time changes to their network service or pre-schedule bandwidth modifications to support high-data usage scenarios such as backup or replication, large multi-point high definition video conferencing calls, software updates and cloud computing resource allocations. Masergy ISC is available as a desktop application or a mobile app on iOS and Android platforms.
"Masergy was the first company to offer enterprises the ability to dynamically control their network services in real time through our award-winning Intelligent Service Control (ISC) application," said Tim Naramore, Masergy's Chief Technology Officer. "Driven by customer requests, we recently added the calendaring function, enabling customers to pre-define network modifications to closely align IT with their specific business needs. We are constantly adding new enhancements to our service and are proud that our innovation has been recognized by Light Reading."
Light Reading Editor-in-Chief Ray Le Maistre said, "The quality of the entries across all the categories was extremely high, resulting in a very compelling group of finalists. They also reflect the ongoing innovation we're all witnessing in the communications services and technology sectors."
Judging was conducted by Light Reading's editors and the analyst team from Heavy Reading (http://www.heavyreading.com).
The Leading Lights Awards winners will be announced at an awards dinner in Chicago on Tuesday, June 17, to coincide with the Big Telecom Event (http://www.bigtelecomevent.com/chicago/).
About Masergy
Masergy owns and operates the largest independent global cloud networking platform for enterprises. Our managed solutions with fully integrated real-time analytics, global unified communications as a service (UCaaS), security as a service and software defined network control help businesses compete in the global marketplace. Masergy's patented technology, customizable solutions and unmatched customer experience are why a growing number of global enterprises rely on Masergy to deliver performance beyond expectations. For more information about Masergy visit www.masergy.com or follow us on [email protected], Blog, LinkedIn and Facebook.
About Light Reading
Light Reading (www.lightreading.com) combines its research-led online communities and targeted events portfolio to help those in the global communications industry make informed decisions. Lightreading.com is the ultimate source for telecom analysis for more than 350,000 subscribers each month, leading the media sector in terms of traffic, content, and reputation. Light Reading produces targeted communications events and focused one-day conferences each year for cable, mobile, and wireline executives across five continents.
Media Contacts:
Betsey Rogers
Public Relations
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Tel: 603-886-7087
[email protected]
Light Reading
Meryl Franzman
Beyond Words Communications Inc.
[email protected]
Tel: 617-739-1769
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Mayor of London Boris Johnson won't be attending Pride Parade
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Cultural Commentary
The heroes who signed the Declaration of Independence
Category: Cultural Commentary Written by Jim Denison
Not everyone who signed the Declaration enjoyed such a storybook ending to his life.
Dr. Lyman Hall was accused by the British of high treason; his plantation and home were destroyed, and he and his family fled to Philadelphia until the war's end. George Walton was captured in battle and became a British prisoner of war. William Hooper was disowned by his father for supporting the revolutionary cause; when the British destroyed his estate, he became a fugitive until the war's end. Thomas Heyward was injured and captured by the British during the Battle of Charleston, spending a year in a prison camp. Arthur Middleton lost his plantation and spent nearly a year in a prison camp.
Thomas Nelson, Jr. was a very wealthy planter and merchant from Yorktown, Virginia. When British General Cornwallis made the Nelson family mansion his headquarters, Nelson encouraged General Washington to destroy it. Carter Braxton lost most of his considerable wealth during the war, including his ships and landholdings. George Clymer's family hid in the woods while the British ransacked their house.
William Floyd and Philip Livingston lost their Long Island estates to the British army. Francis Lewis lost his Long Island estate as well; British troops also captured his wife and held her in such deplorable conditions that she never recovered her health. Lewis Morris' estate was destroyed by the British, as were the homes of Josiah Bartlett and William Ellery.
British troops captured and imprisoned Richard Stockton. John Witherspoon, president of Presbyterian College of New Jersey (now Princeton University) lost his son in the war. John Hart lost his farm and mills to the British; he and his wife died soon thereafter. And Abraham Clark's two sons were captured by the British and held on the notorious prison ship Jersey, where hundreds of Americans perished.
None of these men knew the sacrifice they would make when they chose to "mutually pledge to each other our Lives, our Fortunes and our sacred Honor." They did so "with a firm reliance on the protection of divine Providence." As we honor their courage today, let us seek that same divine protection for the nation their heroism birthed. God's word is clear: "No king [or nation] is saved by the size of his army; no warrior escapes by his great strength." Rather, "the eyes of the Lord are on those who fear him, on those whose hope is in his unfailing love" (Psalm 33:16, 18).
Does America fear God today? Would you pray for our nation to place our hope in his unfailing love?
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Hotel Bh Bicentenario, Bogota
- Free buffet breakfast, free WiFi, and free parking
Main amenities
- 64 guestrooms
- Restaurant and bar/lounge
- Fitness center
- Business center
- Airport shuttle
- 24-hour front desk
- Daily housekeeping
- Self-serve laundry
- Meeting rooms
- Multilingual staff
- Luggage storage
- Tour/ticket assistance
What's around
- In Old Town La Candelaria
- Plaza de Bolivar (0.6 mi / 1 km)
- Torre Colpatria (0.9 mi / 1.5 km)
- Gold Museum (0.2 mi / 0.3 km)
- Iglesia de la Tercera Orden (0.2 mi / 0.4 km)
- Rosario Square (0.3 mi / 0.4 km)
For families
- Private bathroom
- Daily housekeeping
- Laundry facilities
- Hair dryer
- Coffee/tea maker
- Minibar
Hotel Bh Bicentenario, Bogota
Hotel Info: 866-539-8117from $52
- Standard Single Room
- Standard Double Room
- Standard Twin Room
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 64 rooms
- This hotel is arranged over 6 floors
- Check-in time starts at 3 PM
- Check-out time is noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Children (10 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Parents must have child's birth certificate and photo ID *
- No pets or service animals allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle (available on request) *
- Free self parking
Nearby Three Star Bogota hotels
In the hotel
- Free buffet breakfast daily
- Restaurant
- Bar/lounge
- Room service (during limited hours)
- Fitness facilities
- Business center
- Number of meeting rooms - 3
- Meeting rooms
- 24-hour front desk
- Tours/ticket assistance
- Laundry facilities
- Luggage storage
- Multilingual staff
- Porter/bellhop
In the room
- Minibar
- Coffee/tea maker
- Premium bedding
- Private bathroom
- Hair dryer
- Cable TV channels
- IPod docking station
- Desk
- Free WiFi
- Phone
- Daily housekeeping
- In-room safe
Top Bogota hotels
Recently reviewed hotels in Bogota
- Hotel Embassy ParkFrom
"I had a great time. We arrived early morning and they gave us the room right away. The staff is very friendly, ready to help. Breakfast in the morning was great. Beds are really…"Jun 14, 2016
- Hampton by Hilton Bogotá - UsaquénFrom
"it was fantastic ... i went for business and my family had to come for emergency and they acomodate everything to help me change to a bigger room and picked them up at the airport…"Jun 13, 2016
- Hotel Bogota RegencyFrom
"The hotel is clean, people are friendly and rooms are spacious and comfy. The location is great for meetings as it's central to the northern part of the city."Jun 13, 2016
- Hotel Suite ChicóFrom
"First time a this hotel. I picked it for low price, good location and the reviews from other guests. The location is very convenient, you are in a quite neighborhood but very…"Jun 12, 2016
Nearby hotels
Special features
DiningCrepes and Waffles - This restaurant serves breakfast, lunch, and dinner.
Hotel Bh Bicentenario, Bogota's small print
Also known as
- Bh Bicentenario
- Bh Bicentenario Bogota
- Hotel Bh Bicentenario
- Hotel Bh Bicentenario Bogota
If you are traveling with a child your hotel may require you to present the following documents: Parents traveling into Colombia with a child under 18 may be required to present the child's birth certificate and photo ID (passport for foreign visitors) upon check-in. If a relative or legal guardian is traveling into Colombia with the child, that relative or legal guardian may be required to present a notarized consent of travel signed by both parents and a copy of both parents' ID. If only one parent is traveling into Colombia with the child, that parent may be required to present a notarized consent of travel signed by the other parent. Visitors who plan to travel with children should consult with a Colombian consulate office prior to travel for further guidance.
Only registered guests are allowed in the guestrooms.
For transfers, guests must contact the property 24 hours prior to arrival at the number on the booking confirmation.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- A 16 percent city/local tax will be charged
- The national sales tax (16%) is charged upon check-out to citizens of Colombia regardless of length of stay and to foreigners staying 60 consecutive days or more. Foreigners on a tourist visa are exempt from this tax. Furthermore, the tax may apply per room when the room is shared by a taxable and a nontaxable guest.
- Resort fee: COP 9500.00 per person, per night
Optional extras
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Excellent 4.3 /5 from 134 reviews
Great, convenient location. Bright and airy space.
Not a place to be out after dark, but for a tourist visiting, the location is pretty great. Breakfast and room were good. Hotel security was very diligent. For a tourist, I would stay here before giving in and staying way up in the northern (nicer) neighborhoods.
Great Service! I love this hotel.
We couldn't believe our luck with this hotel. Not only was it modern, clean and quiet it was also next to the park where the famous graffiti tour starts and close to where the walking and biking tours begin. The free breakfast was good and some of the staff spoke English. We spent three days exploring Bogota doing all the tours mentioned and couldn't have been happier with this hotel.
great hotel with great hotel service and nice and clean comfortable rooms and all the staff spoke english. Good breakfast and conveniently located.
Is the description of this hotel not correct? Tell us


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Written on: 18/02/2014
Site is easy to navigate. Lots of offers such as free chocolates and discounts. Colour photographic displays accompanied by accurate, detailed descriptions.
Vast ideas for different flower combinations to suit every occasion.
Service to track progress of delivery to ensure peace of mind.
Particularly appealing website.
As rated by our community of reviewers
" Perfect " Read More
Written by owentyers
" AWful " Read More
" Nailed it " Read More
" Great Service " Read More
" Amazed me " Read More
Written by tanuseth


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Cheryl Renee Carver 1963 - 2006 Perry
Mass of Christian Burial for Cheryl Renee Carver, 42, Ozawkie, will be at 10 a.m. Friday at St. Theresa Church in Perry. Burial will be in St. Aloysius Cemetery in Meriden.Mrs. Carver died Monday, July 10, 2006, at a Topeka hospital.She was born Dec. 17, 1963, in Winchester, the daughter of Rex C. and Maxine Ann Heston Buttram. She graduated from Oskaloosa High School in 1982 and received an associate's degree in social work from Allen County Community College. She attended Kansas State University and Washburn University.Mrs. Carver worked as an office assistant for the Dennis Hawver attorney's office in Ozawkie. She was a member of St. Theresa's Church and Fairview Fire Department Ladies Auxiliary in Ozawkie. She was an active volunteer with the American Cancer Society Relay for Life and Heartland Shares program. She was a 4-H leader with the Fairview 4-H Club and served as a coach for youth softball and basketball leagues.She married Jerry Allen Carver Jr. on Sept. 3, 1988, in Perry. He survives, of the home.Other survivors include her parents, Oskaloosa; three daughters, Renee Carver, Natasha Carver and Charley Carver, all of the home; a brother, Brian Buttram Sr., Alabama; two sisters, Lynn McQuillan, Wathena, and Debra Ussery, Lecompton.The family will receive friends from 7 p.m. to 8:30 p.m. today at Barnett-Chapel Oaks Funeral Home in Oskaloosa, where a rosary service will be at 6:30 p.m. today.The family suggests memorials to the Cheryl Carver Memorial Fund, sent in care of Barnett-Chapel Oaks Funeral Home, P.O. Box 416, Oskaloosa 66066.
Gentle Care Animal Hospital 785-841-1919
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Domizil, Vienna
- Free hot/cold buffet breakfast and free WiFi in lobby
Main amenities
- 40 guestrooms
- Valet parking
- 24-hour front desk
- Daily housekeeping
- Multilingual staff
- Luggage storage
What's around
- In Vienna City Centre
- Vienna State Opera (0.6 mi / 1 km)
- St. Stephen's Cathedral (0.1 mi / 0.2 km)
- Viennese City Park (0.4 mi / 0.7 km)
- Spanish Riding School (0.5 mi / 0.8 km)
- Albertina (0.6 mi / 1 km)
Feel at home
- Private bathroom
- Television
- Free toiletries
- Daily housekeeping
- Hair dryer
- Coffee/tea maker
Domizil, Vienna
Hotel Info: 866-539-8117from $96
- Single Room
- Double Room
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 40 rooms
- This hotel is arranged over 4 floors
- Check-in time starts at 2 PM
- Check-out time is 11:30 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Children (6 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- No cribs (infant beds)
- No pets or service animals allowed
- Free WiFi in public areas
- Valet parking *
Nearby Four Star Vienna hotels
In the hotel
- Free hot/cold buffet breakfast daily
- 24-hour front desk
- Luggage storage
- Multilingual staff
- Number of buildings/towers - 1
- Elevator/lift
In the room
- Ceiling fan
- Minibar
- Coffee/tea maker
- Premium bedding
- Private bathroom
- Bathtub or shower
- Free toiletries
- Hair dryer
- Cable TV channels
- Desk
- Phone
- Daily housekeeping
- In-room safe
Top Vienna hotels
Recently reviewed hotels in Vienna
- Grand Hotel WienFrom
"This is an excellent hotel at Old Town Vienna. Major subway line is only one block away. Staff were professional, attentive and friendly. They provided a wonderful upgraded…"Jun 17, 2016
- Leonardo Hotel ViennaFrom
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"The hotel is very nice but the room was odd: shower open to room with no privacy and very small room"Jun 16, 2016
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"Loved outside courtyard for fabulous breakfast. Beautifully prepared with fresh produce. Met many repeat guests and so friendly. Location on Praterstrasse was ideal, we walked…"Jun 16, 2016
Nearby hotels
Domizil, Vienna's small print
Also known as
- Domizil Motel
- Domizil Motel Vienna
- Domizil Vienna
- Domizil Hotel Vienna
- Pension Domizil Hotel Vienna
Optional extras
Valet parking costs EUR 33 per day
Parking is available nearby and costs EUR 32 per 24 hours
Rollaway beds are available for EUR 40 per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Recent reviews
Excellent 4.3 /5 from 255 reviews
Amazing location
Wonderful hotel steps from St. Stephens cathedral. Extremely friendly staff. Reliable wifi. Would stay again and would recommend to friends and family.
Everything about our stay in this hotel was awesome. We were able to book it at the last minute. It was close to everything we wanted to see in Vienna. The breakfast was excellent and very complete. The hosts were friendly and helpful. We will definitely choose this hotel again if we are ever back in Vienna.
Perfect little Pension in a fabulous location.
You really can't beat the location of this hotel. It's literally about a minute walk from St. Stephens Cathedral and in between 2 very close subway stations. I thought the breakfast buffet was pretty good too. My only complaint was that my room on the 4th floor didn't have A/C. However, my friend's room on the 2nd floor did have A/C, so if that's a concern for you pay attention. Maybe there was an option for A/C or not and I missed it.
Is the description of this hotel not correct? Tell us


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Judge sanctions Jehovah's Witnesses
Imposes $4000-a-day penalty for not producing documents in sex-abuse case
Dorian Hargrove 4:30 p.m., June 24
Trying to get a sports writing career off the ground. I figured this would be the best place as any to start. I will put out what I can, when I can. Hoping to gain a cult (not in the sense of overdosing to land on a comet) following. Just kidding, but it would be nice.
Dorian Hargrove 4:30 p.m., June 24
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Juliette Jobs
Looking for jobs in Juliette? Snagajob has great opportunities with the area's leading companies. And applying for Juliette jobs has never been easier. Look at the job listings below, click on a job title that interests you and hit the "apply now" button. Part-time jobs, teen jobs, student jobs and summer jobs are now just a click away. Start your job search now.
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Stockton Williams, Executive Director
Stockton Williams is Executive Director of the ULI Terwilliger Center for Housing. Mr. Williams leads the strategic direction of the Center and the design and implementation of its initiatives, which span a broad range of housing issues, including affordable/workforce, senior, and market-rate housing. He is most recently the author of the ULI publication Preserving Multifamily Workforce and Affordable Housing: New Approaches for Investing in a Vital National Asset.
Mr. Williams has more than 20 years' experience in housing and economic policy, research, advocacy, and development and has held senior leadership positions in the public, private, and nonprofit sectors. Before joining ULI in January 2015, he was Managing Principal of the Washington, D.C., office of HR&A Advisors, which advises cities across the U.S. on complex real estate and economic development projects. Prior to joining HR&A, Mr. Williams served as Senior Advisor in two Federal Cabinet agencies: the U.S. Department of Housing and Urban Development and the U.S. Department of Energy.
He has also been Senior Vice President and Chief Strategy Officer at Enterprise Community Partners; a Senior Advisor at Living Cities; a Senior Legislative and Policy Associate at the National Council of State Housing Agencies; and a developer of affordable housing. He is Chairman of the Board of Groundswell, an innovator in harnessing community economic power for the common good. He holds an M.S. from Columbia University and a B.A. from Princeton University.
Maya Brennan, Vice President, Housing
Maya Brennan is Vice President, Housing, of the ULI Terwilliger Center for Housing. Ms. Brennan joined ULI in 2014 and leads the center's research efforts, including the dissemination of interdisciplinary research through the How Housing Matters portal.
Ms. Brennan joined ULI from the National Housing Conference's Center for Housing Policy, where for seven years she wrote and spoke extensively about affordable housing issues, including how developers and policymakers can use housing to improve outcomes in education, health, aging, and economic self-sufficiency. Maya has authored or co-authored numerous publications, including Veterans Permanent Supportive Housing: Policy and Practice; Comparing the Costs of New Construction and Acquisition-Rehab in Affordable Multifamily Rental Housing; The Impacts of Affordable Housing on Education; and Strengthening Economic Self-Sufficiency Programs: How Housing Authorities Can Use Behavioral and Cognitive Science to Improve Programs.
Ms. Brennan holds a master's of science in urban policy analysis and management from the Milano Graduate School at the New School in New York. She earned a bachelor of arts degree in liberal arts from St. John's College in Santa Fe, New Mexico.


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God has a message for each and everyone of us. as a member I have attend Mount Olive for 3 yrs. I leave with a feeling of joy, god has blessed us with a pastor who is a man of God, who deliver the word. Pastor White brings the word to us we learn and we have fun with it. some churches that I have attended I felt that they were to serious our pastor makes you feel at home so I invite you to come and worship with us your going to want to keep coming back
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From Business: The Crossing Church features various ministries that assist and encourage people of all ages to grow in faith and relationship with Jesus Christ. It has an arts tea…
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6161 E Fowler AveTemple Terrace, FL 33617
106. First Baptist Church of Port Tampa
8306 Interbay BlvdTampa, FL 33616
107. University Baptist Church
2121 E 131st AveTampa, FL 33612
108. Town N Country Baptist Church
7601 Jackson Springs RdTampa, FL 33615
109. Progress Village Christian Academy
8616 Progress BlvdTampa, FL 33619
110. El Bethel Primitive Baptist
11605 N 51st StTampa, FL 33617
111. Rev Ron Satterwhite Reverend
8306 Interbay BlvdTampa, FL 33616
112. Great Comm Baptist Church Inc
8242 Vassar CirTampa, FL 33634
113. Fowler Ave Baptist Church
6161 E Fowler AveTampa, FL 33617
114. Light Of Hope Baptist Church
6013 Laketree Ln Apt GTemple Terrace, FL 33617
115. First Baptist Church
8722 Progress BlvdTampa, FL 33619
116. First Baptist Church Of Gibsonton
9912 Indiana StGibsonton, FL 33534
117. Riverdale Baptist Church
8302 Temple Terrace HwyTemple Terrace, FL 33637
118. St Mark Baptist Church
7221 S Sherrill StTampa, FL 33616
119. Rocky Creek Baptist Church
6403 Theresa RdTampa, FL 33615
120. First Baptist Church of Temple Terrace
10002 N 56th StTemple Terrace, FL 33617
This is a great church family who really believes that they are here to follow Jesus. Very welcoming and loving! I recommend this church to anyone who is looking for more than just a religious service to attend. You will be loved and challenged to live more like Jesus.
If your looking for a place to love for how you are this is the place for you small but big at heart love all of you love tiffany c


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List all words starting with calve, by length
3 words found.
List all words starting with calve, in alphabetical order
Some random words: veil ikat aceldama ovibos lyard tap vocable
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39 products for
39 products
Divine Grey Dot
Black Dot
Porcelain Stripe
Divine Grey Stripe
White Dot
Soft Taupe Dot
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Black Pt De Espirt
Soft Taupe Stripe
Apricot Squeeze Do
Think In Pink
Soft Taupe Pde
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