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|By Maureen O'Gara
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|February 7, 2013 08:00 AM EST
Samsung Ventures has made an undisclosed strategic investment in Boston-based Cloudant and its NoSQL database managed service joining the CIA through its venture arm In-Q-Tel as another hush-hush backer of the four-year-old start-up.
The move comes within hours of Samsung saying it wants to put a lot more money in early stage companies and fundamental research and announcing a $100 million Samsung Catalyst Fund for components and subsystems start-ups. The company's venture arm already has a billion dollars to play with, with more forthcoming as needed.
Cloudant says the money will be used for R&D "to further improve global data distribution technologies and mobile application data management."
It allows that global data distribution, mobile replication and synchronization, expert monitoring, and scalable performance are key features demanded by government agencies, enterprise customers and SMBs, particularly as mobile devices and data proliferate
Samsung, of course, has a vested interest in smartphones and tablets and is looking to Cloudant to push into the large enterprise.
Hyuk-Jeen Suh, a senior investment manager with Samsung Ventures America, said in a statement that "We felt that this is the right time to strategically invest in Cloudant to support the company's vision to manage the proliferation of data to be created by, for example, mobile devices, machine-to-machine (M2M) technologies, and the 'Internet of things' in the future."
Cloudant, which has also gotten money from Avalon Ventures and Y Combinator, can distribute application data across a global network of highly secure, high-performance data centers providing its customers with non-stop data access at low-latency thanks to the cloud. Disclosed investments amount to a mere $4 million.
The company's Database-as-a-Service (DBaaS) works on Amazon, Rackspace, Joyent, Azure and SoftLayer.
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren't yet translating into a true "cloud" experience within the enterprise. What is stopping the growth of the "private cloud" market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between wh...
Jun. 26, 2016 01:00 PM EDT Reads: 692
The initial debate is over: Any enterprise with a serious commitment to IT is migrating to the cloud. But things are not so simple. There is a complex mix of on-premises, colocated, and public-cloud deployments. In this power panel at 18th Cloud Expo, moderated by Conference Chair Roger Strukhoff, Randy De Meno, Chief Technologist - Windows Products and Microsoft Partnerships at Commvault; Dave Landa, Chief Operating Officer at kintone; William Morrish, General Manager Product Sales at Interou...
Jun. 26, 2016 12:45 PM EDT Reads: 741
"A lot of times people will come to us and have a very diverse set of requirements or very customized need and we'll help them to implement it in a fashion that you can't just buy off of the shelf," explained Nick Rose, CTO of Enzu, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 26, 2016 12:30 PM EDT Reads: 1,000
It is one thing to build single industrial IoT applications, but what will it take to build the Smart Cities and truly society changing applications of the future? The technology won't be the problem, it will be the number of parties that need to work together and be aligned in their motivation to succeed. In his Day 2 Keynote at @ThingsExpo, Henrik Kenani Dahlgren, Portfolio Marketing Manager at Ericsson, discussed how to plan to cooperate, partner, and form lasting all-star teams to change t...
Jun. 26, 2016 12:30 PM EDT Reads: 1,089
More and more companies are looking to microservices as an architectural pattern for breaking apart applications into more manageable pieces so that agile teams can deliver new features quicker and more effectively. What this pattern has done more than anything to date is spark organizational transformations, setting the foundation for future application development. In practice, however, there are a number of considerations to make that go beyond simply "build, ship, and run," which changes ho...
Jun. 26, 2016 12:00 PM EDT Reads: 854
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
Jun. 26, 2016 12:00 PM EDT Reads: 1,256
There is little doubt that Big Data solutions will have an increasing role in the Enterprise IT mainstream over time. Big Data at Cloud Expo - to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA - has announced its Call for Papers is open. Cloud computing is being adopted in one form or another by 94% of enterprises today. Tens of billions of new devices are being connected to The Internet of Things. And Big Data is driving this bus. An exponential increase is...
Jun. 26, 2016 12:00 PM EDT Reads: 1,311
In his general session at 18th Cloud Expo, Lee Atchison, Principal Cloud Architect and Advocate at New Relic, discussed cloud as a 'better data center' and how it adds new capacity (faster) and improves application availability (redundancy). The cloud is a 'Dynamic Tool for Dynamic Apps' and resource allocation is an integral part of your application architecture, so use only the resources you need and allocate /de-allocate resources on the fly.
Jun. 26, 2016 12:00 PM EDT Reads: 1,040
The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, discussed how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He also discussed how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors ...
Jun. 26, 2016 11:00 AM EDT Reads: 771
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
Jun. 26, 2016 11:00 AM EDT Reads: 1,021
Your business relies on your applications and your employees to stay in business. Whether you develop apps or manage business critical apps that help fuel your business, what happens when users experience sluggish performance? You and all technical teams across the organization – application, network, operations, among others, as well as, those outside the organization, like ISPs and third-party providers – are called in to solve the problem.
Jun. 26, 2016 10:00 AM EDT Reads: 609
Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, discussed how research has demonstrated the value of Machine Learning in delivering next generation analytics to imp...
Jun. 26, 2016 09:45 AM EDT Reads: 542
It's easy to assume that your app will run on a fast and reliable network. The reality for your app's users, though, is often a slow, unreliable network with spotty coverage. What happens when the network doesn't work, or when the device is in airplane mode? You get unhappy, frustrated users. An offline-first app is an app that works, without error, when there is no network connection. In his session at 18th Cloud Expo, Bradley Holt, a Developer Advocate with IBM Cloud Data Services, discussed...
Jun. 26, 2016 08:45 AM EDT Reads: 755
There are several IoTs: the Industrial Internet, Consumer Wearables, Wearables and Healthcare, Supply Chains, and the movement toward Smart Grids, Cities, Regions, and Nations. There are competing communications standards every step of the way, a bewildering array of sensors and devices, and an entire world of competing data analytics platforms. To some this appears to be chaos. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, Bradley Holt, Developer Advocate a...
Jun. 26, 2016 08:45 AM EDT Reads: 696
Digital Initiatives create new ways of conducting business, which drive the need for increasingly advanced security and regulatory compliance challenges with exponentially more damaging consequences. In the BMC and Forbes Insights Survey in 2016, 97% of executives said they expect a rise in data breach attempts in the next 12 months. Sixty percent said operations and security teams have only a general understanding of each other's requirements, resulting in a "SecOps gap" leaving organizations u...
Jun. 26, 2016 08:15 AM EDT Reads: 984
SaaS companies can greatly expand revenue potential by pushing beyond their own borders. The challenge is how to do this without degrading service quality. In his session at 18th Cloud Expo, Adam Rogers, Managing Director at Anexia, discussed how IaaS providers with a global presence and both virtual and dedicated infrastructure can help companies expand their service footprint with low "go-to-market" costs.
Jun. 26, 2016 01:00 AM EDT Reads: 792
Cognitive Computing is becoming the foundation for a new generation of solutions that have the potential to transform business. Unlike traditional approaches to building solutions, a cognitive computing approach allows the data to help determine the way applications are designed. This contrasts with conventional software development that begins with defining logic based on the current way a business operates. In her session at 18th Cloud Expo, Judith S. Hurwitz, President and CEO of Hurwitz & ...
Jun. 25, 2016 03:00 PM EDT Reads: 1,555
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
Jun. 25, 2016 01:45 PM EDT Reads: 892
19th Cloud Expo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, will feature technical sessions from a rock star conference faculty and the leading industry players in the world. Cloud computing is now being embraced by a majority of enterprises of all sizes. Yesterday's debate about public vs. private has transformed into the reality of hybrid cloud: a recent survey shows that 74% of enterprises have a hybrid cloud strategy. Meanwhile, 94% of enterpri...
Jun. 25, 2016 01:15 PM EDT Reads: 1,233
What does it look like when you have access to cloud infrastructure and platform under the same roof? Let's talk about the different layers of Technology as a Service: who cares, what runs where, and how does it all fit together. In his session at 18th Cloud Expo, Phil Jackson, Lead Technology Evangelist at SoftLayer, an IBM company, spoke about the picture being painted by IBM Cloud and how the tools being crafted can help fill the gaps in your IT infrastructure.
Jun. 25, 2016 12:00 PM EDT Reads: 586


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Long and strong.
The Nau Men's Succinct Trench Coat is a traditional trench made coat modernized. In a sleek and sophisticated style, the Succinct features two-layer construction with a waterproof, breathable membrane and fully taped seams to keep water out. Nau lined this coat in breathable mesh and soft taffeta for fall-to-spring comfort.
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During the great California gold rush, early prospectors sifted through rocks and streams in the hopes of finding a fortune. But bigger hauls were often claimed by going below the surface and digging deeply into mines, where a treasure trove of gold lay waiting to be unearthed. The gold rush may be ancient history, but there's still potential treasure to be tapped--and crises that can be prevented too-by companies that are willing to delve deep into their dark data.
Feb 24, 2009
Optenet, a global IT security company and provider of content filtering solutions, announced the availability of HostSecure, a new solution that can analyze, detect, and report inappropriate user-generated material posted on organizations' websites, blogs, and wikis. The solution is backed by multiple proprietary intelligent content filtering techniques and address analysis, in conjunction with a URL databases. HostSecure also provides reports in real-time, giving the administrator a detailed map of the content uploaded to the web by its subscribers.


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Appointments Committee of the Cabinet announces secretary-leve...Ashok Lavasa, Secretary, Ministry of Environment, Forest and Climate Change, has been placed as Secretary, Department of Expenditure, Ministry of Finance. Lavasa, a 1980-batch Haryana cadre Indian Administrative Service (IAS) officer, will succeed Ratan P. Sify, 2 months ago
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Dry run: Bihar bans liquor in rural areas, restricts sale in urban centres
It was a day of rare solidarity in the Bihar Assembly on 30 March. After unanimously passing the Bihar Excise (Amendment) Bill, 2016 banning countrymade liquor, all MLAs vowed to give up alcohol and encourage others to do so. The liquor ban was one of Chief ...catchnews.com, 2 months ago
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NA school board considers an eight-period day
An eight-period school day may become a reality for students at New Albany High School in the 2011-2012 school year.
New Albany High School Principal Lance Evans came before the New Albany School Board Monday night to discuss this issue.
He said, "Since I have been principal at the high school, I have been looking at ways in which we could change things at the school."
Evans said that one of the reasons for this addition of an extra period is to allow students more time to study and get tutoring help. "Our strongest area of need is in Subject Area Testing Program, especially in Biology I and 10th grade English," Evans said.
He conducted a Power Point presentation for the board members, superintendent, assistant superintendent, and various visitors.
Evans listed eight reasons for the advantages of NAHS going to an eight-period school day.
The following are the advantages he posed:
- Two-hour block for English II and Biology I
- Would align Union County and NAHS schedules
- Would align NAMS and NAHS schedules
- Allows for a common departmental planning time
- Allows for more electives to be added (such as an ACT Prep class and/or Reading classes for struggling students)
- More flexibility in student schedules
- Allows for easier scheduling of Career and Tech classes
- Would allow for extra period off for department heads to assist in teacher development
Evans is proposing two schedules. Both schedules have the first bell to class at 7:40 a.m. The first schedule proposes school to end at 3:22 p.m. and the classes are 50 minutes long. The second schedule proposes school to end at 3:12 p.m. and those classes would be 47 minutes long. Currently, NAHS has seven periods and school ends at 2:58 p.m.
"Maybe the solution would be something in the middle to accommodate transportation/bus routes," said Evans. " NAES and NAMS times would not change, but possibly the buses would just pick up NAHS students last."
He said that he has talked to some of the teachers at the high school and they like the idea.
Dr. Jason Dees, school board member, suggested that the board discuss the possibility of pushing the school day forward and students starting school later in the day. He also posed the question of the school considering block scheduling.
The board decided to peruse the information that Evans presented and talk about all of these concerns in further detail at a non-regularly-scheduled meeting that will be held on March 21, 2011 at 5:30 p.m. in the New Albany School District Administration Office.
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insuranceNEWS.com.au | Life+Health insuranceNEWS | insuranceNEWS (the magazine) | insuranceNEWS Jobs
1 July 2016
Adrian Kitchin has been named the new MD of Insurance Advisernet Australia (IAA) and Insurance Advisernet New Zealand (IANZ).
The appointment is effective from July 1. Mr Kitchin is at present Director Operations for IAA and IANZ.
He will also be responsible for new underwriting agency iaAgency and Insurance Advisernet Financial Services business units.
Mr Kitchin has been with the company six years.
The Advisernet Group is expanding into the UK and North America, and Mr Kitchin told insuranceNEWS.com.au he is enthusiastic about replicating the IAA model in the expansion.
He says the Advisernet model "allows brokers the benefits of a national group while operating at a local level".
The group's expansion has spurred other senior promotions.
Drue Castanelli has been promoted to GM, retaining responsibility for the northern region and adding functional responsibility for systems and business, reporting and analysis across the group.
John Burke has been promoted to GM, retaining responsibility for the southern region and adding functional responsibility for strategic recruitment and engagement with the iaAgency division.
Karenne Muston has been promoted to Manager, Compliance and Risk, with responsibility for compliance in Australia and New Zealand.
Catherine Whitaker, the Director Finance and Dale Coombes, the Director Compliance and Risk, will take on global roles in their areas of expertise.
Founding director Fred Allsopp moved to the UK last year to replicate the IAA model there and Paul Baldacchino, Chubb VP Strategic Marketing, will be in charge of international operations in the US when he joins the company in July.
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Hamilton confident of overhauling Nico
Lewis Hamilton is confident that he will have the opportunity of overhauling the 22-point deficit he has to Nico Rosberg in the Drivers' Championship standings. Rosberg had a 25 point lead over his Mercedes rival after the first race of the season in Australia, where he claimed the chequered flag and Hamilton was forced into an early retirement. In the next four races, though, Hamilton outpaced his team-mate consistently and won in Malaysia, Bahrain, China and Spain to claim the championship lead for the first time this season. A second place in Monaco saw Rosberg regain a narrow advantage, but after his second DNF of the season in Canada, Hamilton admitted he needs a run of victories to...
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Khin had been dumped by her first alcoholic husband, and was desperate to leave her alcoholic and abusive second husband, when a neighbour approached her with a job offer. Khin, then 33 years old, had never even completed primary school so her prospects were slim. The allure of decent work as a domestic helper in the Burmese town of Muse seemed to outweigh the inherent risks.
Leaving behind her husband - and hometown of Mandalay - Khin and her young daughter travelled with her neighbour to the eastern city of Muse. The next morning she saw him arrange for a temporary passport - which struck her as strange. They then drove to the border of China where Khin says a Chinese man paid her neighbour 20,000 MMK. (NZ $28). I ask Khin if she believes her neighbour intentionally sold her as a bride. "Yes, but I had no idea at the time," she tells me via a translator over the phone.
According to the International Labour Office, victims of trafficking are often approached with false offers of a job and are then redirected into situations of sexual or labour exploitation. World Vision's expert in human trafficking Melissa Stewart calls this "disorganised crime", saying "it involves a lot of loose affiliations between people to get a person into a position of exploitation. It doesn't operate in the kind of organised crime network or mafia that you might see in other issues, like sex trafficking."
In 2011, officials in Burma identified 177 victims of trafficking, as reported in the US government's "Trafficking in Persons Report 2012". 69% of these cases were women and girls subject to forced marriage in China. But during a presentation of these numbers a senior official apparently remarked that this data under-represents the true magnitude of the problem. The same report quoted China's Director of the Ministry of Public Security's Anti-Trafficking Task Force as saying that "[t]he number of foreign women trafficked to China is definitely rising".
A one-and-a half hour bus ride later, Khin would find herself in Chinese territory - where precisely she still isn't sure - arriving at a guesthouse where she was resold for 2,000 RMB, (roughly NZ $418). Khin says it was only here, where every evening different men would come to see her, she finally understood what was taking place. "They treated me like an animal," she says. The female broker never let Khin out of her sight, and threatened her life when Khin objected to her captivity.
Eventually Khin was informed she had been traded to another broker based in Shandong province, and before making the seven-day journey must part with her baby. "They said if I brought her it would be impossible to sell me," she says. "So they assured me they would send my daughter back to Mandalay." Faced with little other choice, she carefully wrote down her address, and with a broken heart, left her daughter behind.
In the month following Khin struggled to eat. "I felt crazy, like I'd lost everything," she says. But the broker in Shandong was more successful and after one month a Chinese man, who Khin describes as short with a light complexion, asked if she was willing to marry him. Another Burmese woman in the guesthouse convinced Khin marriage would be a better alternative to their current prison.
Khin's soon-to-be-husband, Jiang Zhigang, was a factory worker in his mid-20s and a typical "customer" of the country's underground market for both local and foreign brides. With a gender imbalance of 108 boys for every 100 girls (an unfortunate side effect of the "One Child Policy"), for many working class men the minimum requirements for marriage (which can include an apartment, car and salaried job) have simply become too high. Yet traditional Chinese values dictate marriage and children as the pinnacles of life.
Khin says the first week in her new home was marked by boredom, compounded by a language barrier. But slowly she began to pick up a few words in Chinese, and Zhigang showed her how to work on the family farm where they grew corn and rice. In the evenings she would eat alone while her husband - unaccustomed to her foreign cooking - would drive over to his parents place.
She says her initial anger towards her husband faded as Zhigang proved to be good-natured, kind and ever accommodating to her needs. Except, of course, the one thing she truly wanted which was to go home. During her six-year stay in China she was neither allowed to call nor visit home out of fear she would run away. Yet escape was never far from her mind.
Nor was Khin entirely cut off from her home country. There were six other Burmese women living in nearby villages and they would meet in the local market or visit one another's home. She says some viewed their situation as preferable to their lives in Burma where they would struggle every day just to survive. Which is why when Khin proposed escaping, only one agreed to go with her.
According to work by NGOs, for the majority of these Burmese women there are only two ways home: escaping by one's self, or arrest and deportation. On the day of her escape Khin had already been living with her husband for several years and had a one-year-old son called Lone Htaw. In the early afternoon while her husband was at work, she pilfered 5,000 RMB (roughly NZ $1050) hidden in the house, took her son and made a run for it.
It would be another arduous seven days crossing the country by train and bus, and then eventually the country border, before she would finally find herself back in her hometown. Khin's sudden appearance shocked her relatives who in her absence had assumed her dead, and even held a memorial service.
With the support of the NGO World Vision, Khin now runs a small business selling textiles and vegetables. According to Melissa Stewart, there is a huge risk for re-trafficking if the fundamental vulnerabilities that led to the victim's original trafficking aren't addressed, so a lot of the work they do is finding these women alternative sources of income.
"Our goal is to ensure people are safe, can make better choices and that they're empowered. And if there's way to do legal redress and work with the cops to get some arrests we will certainly do that as well," says Stewart.
But such arrests are rare. "We used to call this 'the perfect business'," adds Stewart. "Because there's an unending source of vulnerable people who can be exploited and pretty much absolute impunity for offenders." She believes prosecutions of the worst offenders, awareness raising for those at risk and more government-run protective shelters are just some of the vital changes needed. Currently victims in Burmese government facilities receive basic medical care and limited access to psychosocial counsellors, according to the US government trafficking report.
Khin's son Lone Htaw is in now first grade, and I ask his mother if she was ever reunited with her daughter. Talking through tears, the now 45-year-old tells me the traffickers never did as they promised and she last saw her daughter the day they parted in the Chinese guesthouse all those years ago. "I have no idea where my daughter is now," says Khin.
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text:
Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway
The Fat mass and obesity gene (FTO) has been identified through genome wide association studies as an important genetic factor contributing to a higher body mass index (BMI). However, the molecular context in which this effect is mediated has yet to be determined. We investigated the potential molecular network for FTO by analyzing co-expression and protein-protein interaction databases, Coxpresdb and IntAct, as well as the functional coupling predicting multi-source database, FunCoup. Hypothalamic expression of FTO-linked genes defined with this bioinformatics approach was subsequently studied using quantitative real time-PCR in mouse feeding models known to affect FTO expression.
We identified several candidate genes for functional coupling to FTO through database studies and selected nine for further study in animal models. We observed hypothalamic expression of Profilin 2 (Pfn2), cAMP-dependent protein kinase catalytic subunit beta (Prkacb), Brain derived neurotrophic factor (Bdnf), neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2), Signal transducer and activator of transcription 3 (Stat3), and Btbd12 to be co-regulated in concert with Fto. Pfn2 and Prkacb have previously not been linked to feeding regulation.
Gene expression studies validate several candidates generated through database studies of possible FTO-interactors. We speculate about a wider functional role for FTO in the context of current and recent findings, such as in extracellular ligand-induced neuronal plasticity via NTRK2/BDNF, possibly via interaction with the transcription factor CCAAT/enhancer binding protein β (C/EBPβ).
Genome-wide association studies consistently show that fat mass and obesity-related gene (FTO) gene polymorphism is the strongest known genetic factor associated with the development of higher BMI and obesity
Data obtained in studies on Fto knockout and mutant mice (FtoI367A) suggest that FTO is involved in energy homeostasis, metabolism and adipogenesis
In order to determine a molecular mechanistic context for FTO, we utilized information from co-expression-, and protein-protein interaction databases and identified nine candidate genes for functional coupling to FTO. We then performed qRT-PCR expression analysis of murine hypothalami to detect whether the network candidate genes were co-regulated with FTO in a feeding restriction paradigm known to affect FTO expression in a differential manner. We found changes in the expression of Pfn2, Prkacb and Bdnf to parallel FTO mRNA upregulation during food deprivation. We also observed co-regulation of Fto and brain-derived neurotrophic factor (Bdnf) and its receptor TrkB (Ntrk2) in the sated state, and of Fto and Btbd12, Pfn2 and Stat3 in the food-deprived state.
Databases and gene interaction analysis
The FunCoup database (
Mouse feeding models
In the gene expression analysis, we utilized the tissue collected in the experiments described previously
16-hr food deprivation
Chow was removed just before the onset of darkness and mice were sacrificed 16 hours later. Control mice had
Ad libitum chow fed cohort
A larger group of
Generation of cDNA and qRT-PCR
The tissue was kept in RNAlater at room temperature for 2 h and then stored at -80°C until further processing. Tissues were homogenized by sonification (Branson sonifier B 15) and RNA was purified from the samples using the TRIzol (Sigma-Aldrich, Sweden) method
Statistical analysis
D'agostino & Pearson omnibus normality test was used to test normal distribution of gene expression data. Student's t-test was used to test the difference in gene expression between
Database analysis suggests several FTO-interaction candidates
The FTO-interaction networks generated by Coxpresdb and FunCoup are presented in Figure
Figure 1
Network images of FTO and candidates genes
Network images of FTO and candidates genes. Coxpresdb (a) extracts expression data from affymetrix gene-chip arrays (human genome u133 plus 2.0 array and mouse genome 430 2.0 array) run on 3749 human and 2226 mouse samples
Table 1
Candidates genes for FTO-interaction studies based on results from queries in Funcoup, Coxpresdb and IntAct (see Figure 1).
Candidate genes
Profilin 2
Regulates actin polymerization in response to extracellular signals
Neurotrophic tyrosine kinase receptor type 2
Receptor for BDNF
Brain derived neurotrophic factor
involved in neuronal plasticity & differentiation
cAMP dependent protein kinase catalytic subunit beta
Ser/Thr protein kinase, catalytic subunit of AMP-activated protein kinase (AMPK)
Vesicle-associated membrane protein 2. alt. Synaptobrevin-2
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Signal transducer and activator of transcription 3
Transcription factor involved in cell growth and apoptosis. Responds to leptin signalling.
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A
SLX4 structure-specific endonuclease subunit homolog
DNA-repair, endonuclease activity.
Zinc finger and BTB domain-containing protein 20
May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses
Activating transcription factor 7-interacting protein
A regulator of telomerase reverse transcriptase (TERT) expression
STAT3 was included in our analysis due to previous publications suggesting a link between this gene and FTO
Feeding deprivation causes up-regulation of hypothalamic Fto, Pfn2 and Prkacb as well as down-regulation of Bdnf
Fto was significantly upregulated in the hypothalamus of food-deprived mice (p = 0.0012) in good agreement with previously published findings
Figure 2
mRNA expression levels in hypothalamus of 16 hour food deprived vs chow fed mice
mRNA expression levels in hypothalamus of 16 hour food deprived vs chow fed mice. Asterisks denote significance of Student's t-test for difference of means. * = p < 0.05, ** = p < 0.005, *** = p < 0.001, # denotes trend towards significance, p < 0.10.
Figure 3
Analysis of mRNA expression measured with quantitative RT-PCR
Analysis of mRNA expression measured with quantitative RT-PCR. (a) Hypothalamic expression of Ntrk2 and Bdnf correlates with Fto expression in 48 hour
Hypothalamic FTO is co-regulated with Ntrk2 and BDNF in chow fed mice
In the cohort of 48 hour chow fed mice we observed the expression of FTO to show a higher degree of variation compared to chow fed animals in the 16 hour paradigm, which is most likely due to larger individual differences in food consumption. The variation in gene expression was shown to follow a normal distribution. Analysis also showed that Ntrk2-expression correlated positively to expression of Fto (p = 0.0105) while Bdnf correlated negatively (p = 0.0193) (see Figure
Table 2
Correlation data for candidate genes.
95% Confidence Intervals
Goodness of Fit, R square
P value
-0.1531 to 1.286
Chow fed
0.1165 to 0.9898
-0.7881 to -0.1488
-0.3902 to 0.2681
Food deprived
0.2082 to 2.171
-0.54 to 0.73
-52 to 0.64
-1.198 to 1.113
-0.5620 to 1.983
0.01046 to 1.078
-0.4190 to 1.832
0.1775 to 3.198
-0.3582 to 1.664
The expression of genes in bold text are significantly correlated to expression of Fto (p < 0.05). Genes in cursive text were run on chow fed mice in the 16 hour food restriction paradigm. Hypothalamic expression of Ntrk2 and Bdnf correlate to Fto-expression positively and negatively, respectively, in
We identified nine candidate genes for functional coupling and interaction to FTO through database analysis and previous publications. In order to test the validity of this network, expression of network candidate genes was analyzed in a food deprivation model known to induce up-regulation of Fto. We confirmed increased levels of Fto mRNA and observed simultaneous up-regulation of four out of the nine genes in the hypothalamus during food deprivation: Pfn2, Prkacb, TrkB and Stat3; as well as down-regulation of Bdnf. Bdnf, Ntrk2 and Stat3 have been previously implicated in the regulation of energy homeostasis. Bdnf inhibits feeding and increases energy expenditure when injected into the ventromedial hypothalamus (VMH) and paraventricular nucleus of the hypothalamus (PVN)
The expression and co-regulation analysis provides additional evidence for a functional coupling of FTO to the network candidate genes and validates these databases in terms of co-expression
FTO has been shown to exhibit de-methylase activity
Figure 4
In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway
In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway. Ablation of C/EBPs has been shown to reduce the expression of transcription factors Egr1, Egr2 (early growth response protein 1 and 2) and Fos (proto-oncogene c-Fos) following BDNF exposure in cultured neuronal cells
Based on our observations, we speculate that FTO may affect the regulation of ligand-induced neuronal plasticity via BDNF-NTRK2, PRKACB, STAT3 and PFN2. BDNF is involved in neuronal survivability, differentiation and formation of memory
We identified several candidate genes for functional coupling to FTO through database analysis and validated these by expression studies in relevant feeding models via qRT-PCR. Based on these findings, we hypothesized about the molecular context of FTO, discussing a putative involvement in neuronal plasticity by association to transcription factors downstream of ligand activated signaling pathways such as BDNF/NTRK2. These functional results provide new ideas for deducing the mechanisms affected by obesity related FTO-risk alleles.
Authors' contributions
MRA performed the statistical analysis and drafted the manuscript. MSA conceived the study, performed the in silico analysis and participated in the design of the study. HRO and RAC performed the experiments and preliminary analysis. HRO also participated in drafting the manuscript. PKO and JE performed and designed the animal experiments. ASL and RF designed and conceived the study. HBS designed and conceived the study and drafted the manuscript. All authors have read and approved the final verison of the manuscript.
We thank Anica Klockars, Uppsala University for assistance with animal handling. The study was supported by the Swedish Research Council, Brain Research Foundation, Novo Nordisk, Tore Nilsons foundation and Åhlens foundation. R.F. was supported by the Göran Gustafsson foundation.
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Variation in FTO contributes to childhood obesity and severe adult obesity
Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia
Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans
Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations
Fine mapping of the association with obesity at the FTO locus in African-derived populations
FTO genetic variation and association with obesity in West Africans and African Americans
Association of FTO gene variants with adiposity in African-American adolescents
FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study)
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling
Regulation of Fto/Ftm gene expression in mice and humans
The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels
Overexpression of Fto leads to increased food intake and results in obesity
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
The obesity-associated Fto gene is a transcriptional coactivator
Transcriptional and translational control of C/EBPs: the case for "deep" genetics to understand physiological function
The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
Global networks of functional coupling in eukaryotes from comprehensive data integration
COXPRESdb: a database of coexpressed gene networks in mammals
The IntAct molecular interaction database in 2010
Purification of RNA using TRIzol (TRI reagent)
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake
Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus increases energy expenditure by elevating metabolic rate
Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus reduces energy intake
Mechanisms of leptin action and leptin resistance
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
Relating whole-genome expression data with protein-protein interactions
A Bayesian networks approach for predicting protein-protein interactions from genomic data
Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription
BDNF and memory formation and storage
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties
Rapid rewiring of arcuate nucleus feeding circuits by leptin
Trophic action of leptin on hypothalamic neurons that regulate feeding
A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
Brain structure and obesity
Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls
Central leptin receptor action and resistance in obesity
Activation and signaling of the p38 MAP kinase pathway
Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease


text:
There is never much time that goes by between vivid reminders of the human rights record of the mullahs' regime in Iran, or the radical, theocratic ideology that justifies those abuses, writes Mark Williams, a Member of Parliament from the United Kingdom. Under the system of clerical leadership, virtually anything can be criminalized if it is deemed to be out of step with the regime's perspective on what it means to be authentically Muslim or Iranian, he says.
NCRI - On Wednesday, June 15, a group of residents from Sohanak and Morad-Abad, north-east of Tehran, rallied in front of the Iranian regime's Ministry of Roads and Urban Development, protesting against the regime's decision to not allow them to carry out construction.
Two Republicans in the United States House of Representatives are expressing concern over Boeing's tentative agreement to sell about 100 commercial planes to the Iranian regime, warning that the deal could have serious national security implications.
House Financial Services Committee Chairman Jeb Hensarling (R-Texas) and Rep. Peter Roskam (R-Ill.), who holds a seat on the Ways and Means Committee, said that U.S. businesses should not take part in "weaponizing" Iran's regime.
High-ranking Syrian opposition delegation meets Mrs. Maryam Rajavi,
President-elect of the Iranian Resistance
NCRI – Agents of the Iranian regime's suppressive state security forces (police) beat a bakery owner with batons earlier this week west of Tehran.
The regime's agents came to close down the bakery, in Beheshti Street in Heidar-Abad on Sunday, June 12, for selling food during Ramadan.
NCRI - The victims of Negin-E-Gharb housing cooperative scam protested in front of the regime's parliament building in Tehran on Tuesday, June 14.
They protested against the fraud committed by the company that have not delivered the apartments of Vardavard in the Iranian capital in the past 16 years.
NCRI - Coal miners from the East Alborz (Alborz-E-Sharghi) Company, in northern Iran, have been protesting for three consecutive days in front of the company office. Their protest against the transfer of ownership into corporate-leased mining complex lots began on Sunday and by Tuesday was continuing, according to local reports.
During the protest, the workers raised the issues of their unpaid and delayed salary payments. The repressive police officers fearing the workers' fury released the three protesters they had detained on the first day of the rally.
NCRI - A group of people in Parsian, in Iran's southern province of Hormozgan, rallied this week in front of the office of the regime's local governor to protest against the entry of certain security assembly members of Lamerd to Kooshkenar County.
As soon as the members of Lamard security assembly came to Akbari village, located in Kooshkenar County, local people started to gather to block their entry to these areas. Finally, the staff were expelled from the village.
NCRI - On Saturday, June 11, truck drivers continued their protest and strike in Bushehr Terminals, southern Iran.
The regime's police officers, at the behest of governmental agents, asked the truck drivers to end the rally. After that, they raided the crowd, beating and arresting about thirty of the drivers.
NCRI - The governor of Borujerd, western Iran, admitted to the closure of factories and the unemployment of thousands of workers in an already critical economic situation.
On Monday June 13, Moslem Pour-Ghasemian, said: "80 [factories both small and large] in Borujerd have lost their capacity in production and performance due to the economic crises."He explained that 50,000 workers have lost their jobs and admitted that this issue has created a "livelihood crisis."
NCRI - The Iranian regime's suppressive state security forces harassed a disabled man who was playing music near the intersection of Valiasr-Taleqani streets in Tehran on Sunday, June 12. This evoked a strong reaction among the shopkeepers and people in the area.
The protest was so strong that many drivers, including a number of taxi drivers, got out of their cars to join the skirmish against the agents and the regime's Mayor of Tehran. Being engulfed by the people, the mercenaries apologized to the old man out of fear of the furious crowd and left very quickly.
NCRI - According to the state-run media, the clerical regime's suppressive forces arrested a number of municipal workers who had gathered in the city of Ahwaz, in southwest Iran.
On Tuesday, June 14, ILNA news agency reported that following a protest gathering a day earlier by a group of district 4 municipality workers in Ahwaz, the repressive security forces arrested at least 24 workers.
NCRI - In an editorial on Monday, June 13, the state-run Resalat newspaper admitted the dire economic situation of the Iranian regime.
Referring to the closure of factories and manufacturing units, the newspaper wrote: "The closure of ARJ factory after 60 years of economic work sounded the alarm bells in the business environment. Every day, dozens of bad news stories are released about the closure of production units. More than 7000 production units in industrial cities have recently been closed. Expensiveness has increased the concerns."


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January 18, 2009
A Pound of Flesh
House Speaker Nancy Pelosi on Fox News Sunday says she's open to the idea of prosecuting Bush administration officials.
"I think you look at each item and see what is a violation of the law and do we even have a right to ignore it," the California Democrat said. "And other things that are maybe time that is spent better looking to the future rather than to the past."
Last week when DrewM. posted something about the awfulest torture-y mistreatment of sociopathic jihadi Mohammed al-Qahtani, I mentioned something along the lines of "more grease for the prosecute Bush for war crimes" skid.
Today Pelosi tentatively put her "high road" endorsement on the nonsensical ravings of jerks like John Conyers, who's been beating this drum for a while now.
She whitewashes the political payback aspect, saying "hey, the law might compel us". Rubbish.
They have all the cards. All. The. Cards. I'm just spitballin here, taking a look at the ol crystal balls, but I'll bet you my next paycheck there will be more recriminations, investigations, and special prosecutors.
And lots of pretense. Obama will float above the fray. Because Hope and Change doesn't sully itself in political revenge.
"I don't believe that anybody is above the law," he [Obama] told ABC News a week ago. "On the other hand, I also have a belief that we need to look forward as opposed to looking backwards."
We simply cannot have this victory. Not when the Democrats staked so much on losing, and lost the bet. They have no intention of losing the argument. Instead they demand the house invalidate the spin of the wheel, and redo with new odds. They weighed "it wasn't worth the cost", realized that was a losing argument, and instead chose the "crimes were committed in the execution of this flawed policy" path. They will do everything they can to make certain the Iraq war is bathed in shame and self-loathing.
It's what they do. And while I hate to say so, they're pretty fucking good at it.
5 WTF. I mean, seriously. What the hell do these fuckers want? They won the election. Will they not be satisfied until they completely trash this man and those who work for him? Posted by: MDH3 at January 18, 2009 06:21 PM (hHSMt)
No. They will not be satisfied until they completely trash Bush, and the war. And conservatism.
Honestly, I don't think even that will satisfy them. It'll keep them sedated for a bit. That's all.
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World Muslim Leaders Apologize for Nick Berg's Beheading
Michael Moore Goes on Lunchtime Manhattan Death-Spree
Milestone: Oliver Willis Posts 400th "Fake News Article" Referencing Britney Spears
Liberal Economists Rue a "New Decade of Greed"
Artificial Insouciance: Maureen Dowd's Word Processor Revolts Against Her Numbing Imbecility
Intelligence Officials Eye Blogs for Tips
They Done Found Us Out, Cletus: Intrepid Internet Detective Figures Out Our Master Plan
Shock: Josh Marshall Almost Mentions Sarin Discovery in Iraq
Leather-Clad Biker Freaks Terrorize Australian Town
When Clinton Was President, Torture Was Cool
What Wonkette Means When She Explains What Tina Brown Means
Wonkette's Stand-Up Act
Wankette HQ Gay-Rumors Du Jour
Here's What's Bugging Me: Goose and Slider
My Own Micah Wright Style Confession of Dishonesty
Outraged "Conservatives" React to the FMA
An On-Line Impression of Dennis Miller Having Sex with a Kodiak Bear
The Story the Rightwing Media Refuses to Report!
Our Lunch with David "Glengarry Glen Ross" Mamet
The House of Love: Paul Krugman
A Michael Moore Mystery (TM)
The Dowd-O-Matic!
Liberal Consistency and Other Myths
Kepler's Laws of Liberal Media Bias
John Kerry-- The Splunge! Candidate
"Divisive" Politics & "Attacks on Patriotism" (very long)
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Editor Mike Bracken has already brought you his opinion of Baldur's Gate: Dark Alliance II in the form of a review earlier this month to gauge the success of Black Isle Studios, but now he also brings you an analysis of Snowblind's adventures with Champions of Norrath. How does this PlayStation 2 release stack up against the heavy competition?
For this answer and Mike's full review, click the link below.
Darksiders II June 26 • 9:00am PDT/12:00pm EDT
Wild Arms 2 July 3 • 9:00am PDT/12:00pm EDT
Lunar 2: Eternal Blue Continues! Every Monday • 5:00pm PDT/8:00pm EDT
Grandia II Continues! Every Wednesday • 2:00pm PDT/5:00pm EDT


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St. Cloud Remembered on Facebook by local historian John Lund
It's called "St. Cloud Remembered" and it contains a myriad of photos and stories collected through local historical institutions as well as from residents who have found some very interesting artifacts that they'd like to share. In this installment of the Untold Stories of Central Minnesota, Arts and Cultural Heritage Producer Jeff Carmack talks with lifelong St. Cloud resident John Lund about a Facebook project that he's begun documenting the history of our area. Over the first couple of months of its existence, the page has accumulated nearly 5,000 followers, and the online conversation is just beginning. This podcast originally aired on KVSC on April 18, 2013.
Latest News
Fundraisers Are Taking Place This Summer To Support Child Care For SCSU Veterans
Drivers: County Road 1 Reconstruction Begins Wednesday In Stearns County
Metro Bus Trolley Is Taking Community Members On Free Rides During Summertime By George
St. Cloud Police Department Needs Help From Public In Search For Missing Woman
St. Cloud Man Arrested After Allegedly Robbing His Mother's Home Monday
St. Cloud Man Arrested After Allegedly Threatening Three With A Baseball Bat Sunday Night
New License Plate Designs Will Benefit The State's Parks And Trails, Voting Now Open
One Man Was Airlifted To The Hospital After Motorcycle Crash Sunday Afternoon
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Aug. 30, 2013Physicians join CoxHealth in Springfield, Lebanon, MonettJohn Spencer, MD, has joined CoxHealth Springfield Inpatient Physicians, Emily Mebruer, MD, has joined CoxHealth Center Lebanon, Tommy Trent, DO, has joined the emergency medical staff in the Cox Monett ER, and Stacy Harms, MD, has joined Monett Surgical Associates as a general surgeon.
Aug. 29, 2013Specialists join Ferrell-Duncan ClinicTania Papsdorf, MD, has joined Ferrell-Duncan Clinic as a neurologist, and Dennis Ng, MD, has joined Ferrell-Duncan Clinic as a gastroenterologist.
Aug. 27, 2013CoxHealth receives $350,000 grant from Missouri Foundation for HealthCoxHealth has been awarded a $350,000, 12-month grant from the Missouri Foundation for Health to help people throughout the Ozarks enroll in Missouri's health insurance marketplace when it opens on Oct. 1.
Aug. 22, 2013Free class for parents and coaches to cover injury warning signs, preventionCoxHealth is offering a free Sports Safety 101 class with to help parents and coaches learn more about certain injuries and conditions, including concussions and heat-related illnesses.
Aug. 16, 2013CoxHealth nurse elected to help lead state associationCindy Potts, RN, has been elected to serve as secretary of the Missouri Chapter of the American Psychiatric Nurses Association.
Aug. 16, 2013CoxHealth employee receives state awardChristie Drew, paramedic and community outreach coordinator for Cox EMS Christian County, was recently named "Outstanding Paramedic of the Year" by the Missouri Emergency Nurses Association.
Aug. 15, 2013Mercy and CoxHealth team up for Medical Mile walk and dedicationOn Aug. 24, CoxHealth and Mercy will host an event to get everyone familiar with the Medical Mile Trail, which runs along National Avenue and connects Mercy to the north with CoxHealth to the south.
Aug. 14, 2013CoxHealth rated best in Springfield for overall surgical safety by Consumer Reports magazine In its September issue, leading consumer magazine Consumer Reports has rated CoxHealth as the top hospital in Springfield for overall surgical safety.
Aug. 12, 2013Three providers join CoxHealthProviders have joined CoxHealth Diagnostic Clinic, Cox Family Medicine of Monett and CoxHealth Infectious Diseases Specialty Clinic.
Aug. 12, 2013Clinics offer alternative for athletes injured in Friday night play CoxHealth and Ferrell-Duncan Clinic are again offering Friday Night Clinics to all area high school athletes with sports-related injuries, beginning Friday, Aug. 23 at 9 p.m.
Aug. 9, 2013CoxHealth opens Obstetrical Emergency DepartmentCoxHealth recently opened an Obstetrical Emergency Department (OBED) inside the Labor and Delivery unit at Cox South.
Aug. 9, 2013Three providers join CoxHealth Springfield Inpatient PhysiciansTwo hospitalists and a certified physician assistant have joined Springfield Inpatient Physicians.
Aug. 9, 2013Class for kids and parents teaches necessary stay-at-home skillsCoxHealth offers tips for families who are considering leaving their children home alone.
Aug. 8, 2013Physician joins Cox Family Medicine of Monett Deborah Jarrett, DO, has joined Cox Family Medicine of Monett.
Aug. 8, 2013Three physicians join Ferrell-Duncan ClinicThree physicians have joined the pulmonary and critical care medicine, OB/GYN and internal medicine departments at Ferrell-Duncan Clinic.
Aug. 6, 2013CoxHealth announces latest DAISY Award winnersMeet the latest winners of the DAISY Award, which recognizes extraordinary nurses.
CoxHealth, Springfield, Missouri | (417) 269-3000Ranked one of Missouri's Best Hospitals by U.S. News & World Report
Copyright © 2016 CoxHealth. All rights reserved.


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Altisource Portfolio Solutions S.A. is a premier marketplace and transaction solutions provider for the real estate, mortgage and consumer debt industries. AltiMore
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Enterprise_Iteration-NT.1472[01] SEIDXWK-27


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Contour Style- Dive, Complot Magazine, July 1, 2010
Credit: Santiago & Mauricio
Creative #: 132296110
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Contour Style Dive Complot Magazine July 1 2010 Stock PhotoAdult,Adults Only,Arts Culture and Entertainment,Challenge,Cloud - Sky,Color Image,Competition,Copy Space,Danger,Day,Distant,Diving Board,Diving Into Water,Fashion,Fashion Model,Florida - US State,Full Length,Healthy Lifestyle,High Up,Leisure Activity,Low Angle View,Miami,One Man Only,One Person,One Young Man Only,Only Men,Outdoors,Part of a Series,People,Photography,Portrait,Recreational Pursuit,Skill,Sport,Swimming Trunks,USA,Vertical,Vitality,Young AdultPhotographer Santiago & MauricioCollection: Contour Style Model poses at a fashion shoot for Complot Magazine on January 19, 2010 in Miami, Florida. *** Local Caption ***


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Easy Ikea Lack Sofa Table Hack
This is such an easy project and the end
Hi! I'm Tasha from Designer Trapped in a Lawyer's Body. Follow me as I renovate my outdated home one room at a time!
I love transforming spaces that seem hopelessly ugly to B.E.A.U.T.I.F.U.L. I enjoy all aspects of DIY. We have done it all--flooring, tiling, electrical, plumbing, painting galore, etc.


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Riverton, UTUSA
June 11, 2014
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Well...I'm a recruiter. I've been doing this for a long time, but I'm new to technology recruiting. I'm trying to learn more and that's why I'm here.
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June 24, 2016
Currently: 104° — Complete forecast
L.E. Baskow
East Career and Technical Academy students and their culinary instructor David Watkins celebrate their win in the Culinary Collision at the Whole Foods Market in Town Square on Thursday, March 13, 2014.
© Las Vegas Sun, 2016, All Rights Reserved


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Dometic Marine established a new base in the Gulf of Mexico as part of its strategy to target further business in the commercial sector.
The addition of the facility in Slidell, La. to its extensive global network places the HVAC and toilet systems specialist at the heart of the United States' commercial market.
Driven by the current boom in the oil and gas industry, the shipyards are facing a surge in demand for oilfield-related orders including Offshore Support Vessels (OSVs) and Dometic Marine is now perfectly positioned to respond to the needs of Gulf shipyards, according to the company.
As suppliers of durable and robust equipment which is specifically designed for commercial applications, Dometic Marine said its increased presence in a region of such huge importance as a source of oil and natural gas will help to facilitate contract opportunities to supply equipment for OSVs, rigs and platform supply vessels.
Nathan Farr, OEM Account Manager, Dometic Marine, said, "The new office in Slidell has already improved our customer service and response times to our existing clients and we are confident that it will help us to secure new business in sectors such as oil and gas, military, government and other areas in the commercial market."
"The Gulf of Mexico is the center of the commercial market in the U.S., with a concentrated number of shipyards to service the oil and gas industry," he continued. "Our increased presence in this important region will increase our commercial market share and provide a higher level of customer support."
Dometic Marine has a line of air conditioning systems to handle and suit a variety of vessels, from its high-capacity chilled water systems to its smaller self-contained systems, the company said.
The company has 36 sales offices covering 28 countries.
Nathan Farr, OEM Account Manager, Dometic Marine
Maritime Today
The Maritime Industry's original and most viewed E-News Service
United Arab Shipping Company (UASC) said its six shareholding states backed a merger deal with German container shipping line Hapag-Lloyd AG at a meeting on Wednesday.
Following last week's landmark referendum results, VesselsValue has compiled a list of the top five U.K.-based shipowners and their total fleet value in USD billions.
U.S. Federal Maritime Commission (FMC) Commissioner William P. Doyle issued a statement on the upcoming implementation of the SOLAS Convention's verified gross mass (VGM) requirements:
On Friday,
Hybrid RoPax ferry Texelstroom has been delivered to Koninklijke N.V. Texels Eigen Stoomboot Onderneming (Royal TESO).
This latest generation symmetrical ferry is powered by efficient,
Radio Holland Canada has won two major contracts to support the Canadian Coast Guard. Public Works and Government Services Canada, which is responsible for government procurement,
The Polar Research Institute of China has ordered a new 14,300gt polar research vessel. Designed by Aker Arctic Finland, it will be the first vessel of its type to be built in China,
MacGregor, part of Cargotec, has won an order to supply MacGregor offshore cranes and a Triplex handling system for a 14,300gt polar research vessel being built
Blackmer, a company in positive displacement and centrifugal pump and reciprocating compressor technologies, has a relationship with the U.S. Military that dates


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An Elk River man accused of killing his ex-girlfriend in her Kasota apartment last year pleaded guilty in Le Sueur County Court today (FRI). 24-year-old Tyler Andrew Wicklund faces a minimum of 30 years in prison after pleading guilty to 1st-degree murder with intent while committing a felony as well as being a felon in possession of a firearm. He had been charged with premeditated 1st-degree murder and murder while committing a criminal sex act after slitting the throat of 20-year-old Jessica Buboltz on October 29th, 2010. Those charges will be dismissed in exchange for the guilty plea, and rather than life in prison Wicklund will be eligible for parole after 30 years. The plea agreement was reportedly approved by the victim's family. Sentencing will take place November 2nd.
Home » News » Local News » Kasota Murderer Pleads Guilty
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Drake students reunite with Ugandan friends during their visit to campus.
May 27, 2016
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Top Senior
Collaboration, resilience, and compassion: Those are the traits Drake's top senior, Brytani Cavil, says she developed most during her years as a Bulldog.
May 27, 2016
May 27, 2016
Drake branches out
The campus community comes together to observe Arbor Day and maintain the University's standing as a Tree Campus USA.
May 27, 2016
May 27, 2016
Thank you for going All In!
Any way you interpret it, the Drake community gave in record numbers this year.
May 27, 2016
May 27, 2016
Enjoy the Drake Relays from home
Stay connected to the 107th Drake Relays, even if you can't be on campus.
April 20, 2016
April 20, 2016
Road To Rio Starts On the Blue Oval
More than 50 past Olympians and dozens of Olympic hopefuls are set to compete on the Blue Oval as each begins their march towards the XXXI Summer Olympics in Rio De Janeiro.
April 20, 2016
April 20, 2016
History, Tradition, and a Bit of Bling
The inauguration ceremony of Earl F. "Marty" Martin will install a new president and launch a new era—and flaunt the University's traditional jewels.
April 20, 2016
April 20, 2016
The way to a Bulldog's heart? Food.
Drake alumni are making Des Moines delicious and putting its restaurant scene on the map.
March 23, 2016
March 23, 2016
Show highlights 29 students' work
Nearly 100 works entered into the 45th Annual Juried Student Art Exhibition, awards presented to eleven artists.
March 23, 2016
March 23, 2016
Bulldog Super Fan
Alumnus Ron Buel, BN'62, has given substantial gifts of his time and money to Drake University, and attends as many athletics events as he can physically attend.
February 24, 2016
February 24, 2016
ABA head to speak at Drake Law
Paulette Brown, the first African American female president of the American Bar Association (ABA) has focused on diversity and inclusion in the justice system.
February 24, 2016
February 24, 2016
J-Term propels record label
Drake students dive deep into music, media, and money—bringing a live show to the Drake neighborhood while experiencing the workings of the recorded music industry.
February 24, 2016
February 24, 2016
6 things in 2016
It's an eventful year ahead with caucuses, construction, competition, commitment, camaraderie, and courses. Save the date for these six events happening in 2016 at Drake University. There are so many exciting things happening on campus in 2016. Follow us through a year of transformation! 1. Caucuses Drake becomes the caucus capital of Des Moines on […]
January 22, 2016
January 22, 2016
Caucuses as classroom
Students study campaign communication strategies at rallies for Clinton, Carson, and other presidential candidates prior to the Iowa caucuses In a single week, Drake University sophomore Samantha Ohlson spent eight hours at a Hillary Clinton campaign rally in Council Bluffs, four hours at a Putting Families First presidential forum in Des Moines, two hours at […]
January 22, 2016
January 22, 2016
Three alumni lead FBS teams
Only the University of Iowa and the University of Alabama have produced more current FBS head coaches than Drake. Drake University has a long tradition of making what Head Coach Rick Fox likes to call "Impact Men"—men with a burning desire to do something great with their lives. Three of Drake's more recognizable "Impact Men" […]
January 22, 2016
January 22, 2016


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Brandon Lloyd: 'We all knew what we were getting into'
|09.03.12 at 12:47 pm ET
FOXBORO — Brandon Lloyd is a fast learner.
He realized quickly in New England to take nothing for granted, pay attention to every detail and not speak out of line.
He demonstrated all of those traits this week in speaking to the media inside the Patriots locker room.
'It's always exciting to make an NFL roster," said Lloyd, who was the prize addition to the wide receiver corps in the offseason. "There's always a doubt. Nothing's ever for certain. I've prepared and in shape and ready to go. There's always a level of excitement."
He's very aware that he made the team while veteran receivers Deion Branch, Jabar Gaffney and Donte' Stallworth did not.
'Nothing's for certain. It was a competitive camp," Lloyd said. "I haven't been in a camp that was that competitive at the wide receiver position where guys had so much past experience with the starting quarterback, had success in the NFL and then were all battling out for a couple of spots.
'It was definitely competitive. That's the just the way it shook out. We all understood what we were competing for by signing here. It was up to the coaching staff and ultimately how we practiced and played to make the team.'
One receiver that is on the roster is late addition Greg Salas, a former teammate from his days with the Rams. But Lloyd would not reveal much more.
'I can identify him," said Lloyd with a healthy, booming laugh.
Lloyd acknowledged that playing for the Patriots is a different experience than playing for the Redskins, Bears, Broncos and Rams.
'We all knew what we were getting into by coming to training camp here in New England and I think we all did our best to make the team and be productive members of the roster," Lloyd said. 'I think it's just the attention to details. Everybody is really focused on doing the small things right and that's from the coaching staff down to the players. So, I think that's what separates them.'
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- What Could Ninkovich's Position Change Mean for Patriots Defense?
- Who Were Patriots Minicamp Stars


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Real Milan helped Donald McCain and Jason Maguire boost what are already three-figure seasonal totals for the trainer and jockey in the Download BetVictor Spincast App Now Novices' Chase at Ayr.
Maguire was the first to reach a century of winners late last month as he vies with Richard Johnson for second place in the jockey standings, while Cheshire-based McCain is the most successful trainer in the country in terms of numbers.
Real Milan has now only been beaten twice in seven starts and has a perfect record from two starts over fences as he supplemented a ready victory at Carlisle by pulling away from Netminder.
While not flattered by his margin of four lengths, the 1-2 favourite still needed to be scrubbed along by Maguire to keep track of the leader and only asserted properly approaching the last.
The jockey said: "The ground is drying up, so it's very tacky out there, but I was very pleased with his jumping. He might be helped by going in a more competitive race, but he is two from two and has done nothing wrong. He jumped the ditch well, and by then the race was sort of over."
Peter Buchanan, who steered home two of Lucinda Russell's treble on the first day of the meeting, helped continue their momentum in the Follow Us On Twitter At BetVictorRacing Maiden Hurdle. It was a flawless hurdling debut from 5-4 favourite No Deal, who had also won a bumper and a point-to-point.
On a day of family combinations, Emma Sayer enjoyed a memorable first victory over fences aboard her mother Dianne's Sergeant Pink (3-1) in the BetVictor Exclusive Antepost Offer Cheltenham 2013 Handicap Chase.
The cheekpieced gelding looked reluctant during the course of the race but suddenly revived his interest in the home straight and cut down the 5-4 favourite Gleann Na Ndochais, who looked booked for victory up until the final fence.
If Sayer requires a role model, she would be advised to choose Lucy Alexander, who excelled once again in the BetVictor Cheltenham Festival Antepost Pioneers Conditional Jockeys' Handicap Chase on the game grey mare Tipsy Dara (11-4), trained by her father Nick.
Callum Whillans was another to be bold from the front on his father Donald's King Kalium (13-2) in the BetVictor Non Runner Free Bet At Cheltenham Handicap Hurdle and they had enough gas left in the tank to hold 10-11 favourite Rowan Road by two and three-quarter lengths.
14 June 2016John Gosden's Swiss Range remains in French Oaks reckoning
Japanese star A Shin Hikari bids for Royal Ascot first in Prince of Wales's
Godolphin team unconcerned by mile trip for Usherette at Royal Ascot
Wesley Ward expecting Lady Aurelia to fly in Queen Mary at Ascot
Order Of St George faces 17 rivals in Gold run at Royal Ascot
July Cup remains on Danzeno agenda despite Salisbury defeat
Michael Bell to swerve Gold Cup at Royal Ascot with Big Orange
Ventura Storm set to drop in class following French Derby defeat
Thirsk gets go-ahead following morning inspection
Hugo Palmer gives Royal Ascot go-ahead to Architecture
Ground rules out Goldream's King's Stand defence
Jet Setting stays in training with Adrian Keatley
Richard Hannon says Mehmas has 'excellent chance' in Coventry Stakes
Thirsk abandoned due to unsafe racing conditions
Injured Danny Tudhope suffers more Royal Ascot woe
Michael Dods anticipating bold show from Mecca's Angel in King's Stand at Ascot
Kevin Prendergast has Awtaad 'better and fitter' for Royal Ascot raid
Tepin team shrug off going concerns ahead of Queen Anne outing at Ascot
Ground concerns scupper Time Test's Royal Ascot date
13 June 2016Jet Setting goes for a song at Goffs London Sale
John Quinn has great expectations for Carlisle scorer Al Shahaniya
Branch Line excels at Roscommon for Andrew Slattery
Royal runner Dartmouth in Hardwicke hat for Sir Michael Stoute
Undrafted leads 18 confirmations for Diamond Jubilee at Royal Ascot
Setback sidelines Roger Varian's Dawn Of Hope
Michael Dods anticipating bold show from Mecca's Angel in King's Stand at Ascot
Ground concerns raise Buratino Commonwealth Cup doubts
Charlie Appleby mulling Newmarket outing with Nasimi
Marco Botti sets sights on European Group One glory with Euro Charline
Ken Condon eyeing autumn campaign with Success Days
Andrew Balding eyeing York Stakes outing with Tullius
Johnny Murtagh expecting more progression from Derby hero Harzand
Cam Hardie journeys north to spark new life into his career
Ascot ground the question mark for Aidan O'Brien big guns
Ptit Zig roars to French Champion Hurdle glory for Paul Nicholls
Don't Touch tees up July Cup option with Cathedral Stakes triumph
Pretty produces stylish performance to claim Munster Oaks
Royal Ascot rain a pain for Wesley Ward
Irish Oaks winner Covert Love retired after suffering strained ligament
Robert Cowell to make late decision on Goldream King's Stand defence
Henry Candy rates Limato a '50-50' chance to contest Diamond Jubilee heat
Classic trio primed for St James's Palace Stakes clash at Royal Ascot
12 June 2016William Haggas resigned to rain woe for Ajaya
Hoofalong team have full faith in Nathan Evans for Stewards' Cup mission
Jim Crowley left wishing for free Sundays
Spirit Quartz back in business at Cork for Robert Cowell
Red Cardinal best in eventful Salisbury victory
James Eustace resigned to missing out on Hunt Cup with Ice Slice
Chris Stickels expecting Ascot ground to remain on easy side for Royal meeting
Massaat ruled out of Irish Derby date
Goldream takes on 20 in King's Stand Stakes defence at Royal Ascot
Tepin faces 13 rivals as she takes Queen Anne test at Royal Ascot
Exaggerator is well beaten as Creator takes the Belmont Stakes
Mr Lupton in Wokingham frame after Charity Sprint strike
Mick Easterby 'in shock' as Hoofalong lifts Sprint Cup
Easton Angel heaven-sent for Michael Dods in Scurry Stakes
Mutakayyef strikes Ganton glory at York
Ryan Moore gets Mutamakkin home at Sandown
Emily Easterby has champagne sparkle with famous success at York
Destroyer floors Sandown rivals
Ballydoyle headlines Coronation Stakes possibles
Air Force Blue enters Commonwealth Cup picture
11 June 2016Scoop6 carried forward to Royal Ascot after Hoofalong victory scuppers punters
Mr Lupton powers to Charity Sprint success at York
Meadway makes all for Tartan Trophy glory at Musselburgh
Emily Easterby has champagne sparkle with famous success at York
Willie Mullins makes French connection with Un De Sceaux
Mark Johnston to swerve Royal Ascot with Lumiere
Thumbs-up at Leicester after inspection
Hayley Turner awarded OBE in Queen's Birthday Honours list
Acapulco all set for King's Stand at Royal Ascot
Ryan Moore hits Sandown treble
Hawkbill primed to take Tercentenary test at Royal Ascot
Oaks runner-up Architecture still possible for Ribblesdale
Order Of St George tops 21 still in the mix for Gold Cup glory
Charlie Appleby hoping Charming Thought challenge bears fruit at Salisbury
Long-absent Muwaary bids to stamp class on York's Ganton Stakes
Easton Angel aiming to star in Scurry date at Sandown