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Lightning Gremlin Gremlins 2 Neca 2012 Toys R Us Exclusive Electric
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Lightning Gremlin Gremlins 2 Neca 2012 Toys R Us Exclusive Electric:
Looney Tunes 1996 Michigan J Frog Plush Stuffed Animal By Ace Toys 13" Tall
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1998 Warner Bros. Studio Store Tweety Bird Bean Bag Toon Of Terror Halloween,nwt
Hallmark Pepe Le Pew Plush Love Talking With Chocolate Covered Strawberry


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Rush Release Another Concert Clip From 1974
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If rock and roll is dead, Tom Petty and Eric Clapton didn't get the memo -- and neither did the 'Guardians of the Galaxy.'
The two iconic artists have respectively claimed the No...

subset: commoncrawl


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Gulledge Family History & Genealogy
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- Aaron Gulledge to Ann Gulledge
- Anna Gulledge to Bernard Gulledge
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- Calla Gulledge to Clayton Gulledge
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- Denver Gulledge to Edna Gulledge
- Edward Gulledge to Ernest Gulledge
- Erwin Gulledge to Francis Gulledge
- Frank Gulledge to Goldie Gulledge
- Grace Gulledge to Herley Gulledge
- Herman Gulledge to Jacqueline Gulledge
- Jady Gulledge to Joe Gulledge
- Joel Gulledge to Keith Gulledge
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There are 32 days until the 2012 elections. I expect it will get ugly, as it inevitably does. Or uglier, I suppose.
Let Mitt Romney attack President Obama for his failures, let Obama bash Romney for his inconsistencies and let it get personal and gossipy and childish and let us act offended and outraged when the mud is flying fastest while we quietly enjoy it. Without the soap opera stuff all we've got is two guys talking about debt ceilings and Simpson-Bowles and who needs that?
But, I wonder, will it be too much for Obama and Romney and Scott Brown and Elizabeth Warren and all the debate moderators and journalists and advisors and campaign managers to keep their hands off of sports for the next month?
Or will they continue to do what politicians have done for years, which is pretend to care (it's called pandering, something politicians work really, really hard at) about the NFL and NBA and MLB and NHL because they think we care if they care, even if they've proved time and time again that they couldn't be more clueless when it comes to all things sports?
There is this desperate need for politicians to seem like they are just folks, as comfortable sitting at a bar talking sports as they would be at a $10,000 a plate fundraiser at the home of some billionaire in Malibu. And this isn't a Democratic or Republican issue, either. It's an insecurity issue.
John Kerry was embarrassed that his wife is worth millions and millions and millions of dollars, so he overcompensated by sometimes trying his "common folks" impression on the campaign trail. Mitt Romney, also embarrassed by his wealth (for reasons unknown to me, if you are running for president based on your business experience I would think it would be better to have been successful than a failure), thinks he can make people forget about his houses in Colorado and La Jolla and Park City and Lake Winnipesaukee by rolling up his sleeves and wearing jeans when he campaigns at places where he thinks he's supposed to be wearing jeans with his sleeves rolled up.
Politicians, of course, are actors. Barack Obama, Mitt Romney, Scott Brown, Elizabeth Warren, all of them (I mean, have you watched the "On The Road" ads with Brown?). And the ones who don't seem like actors are just really good actors. They are playing a character, plain and simple. And the people who are paid a lot of money to develop that character -- think James Carville, Karl Rove and the like -- believe it's essential that the character is, above all, likable. To the advisors, being the guy you'd rather have a beer with might be as important as being the guy you trust most when dealing with Iran (this also explains the blizzard of "When I was in Missouri, I talked to a guy named Ralph" stories we have to suffer through from these guys during stump speeches and debates -- it's all about trying to seem connected to people they have no connection to).
And that's why so many politicians have tried so hard to convince us that they are real sports fans, just like us. The reality? They second they start talking -- and it's usually off script, which is death for these guys -- about anything sports related they are revealed as complete and total phonies.
We know sports frauds, we really do. You go to a party, or talk to another parent at a school function and it doesn't take long. And it doesn't take much, either. Just a simple "The Red Sox should fire all the players," or "You know, I didn't get a chance to watch the Patriots on Sunday," or "I'm a Yankees, Lakers and Packers fan" and you know what the score is.
But that's OK. That's just another person trying to make small talk, there's nothing nefarious going on. But that's not the case with politicians -- they are trying to fool you. If I can act like a sports fan, even though I'm really not, they will like me. And if they like me, they'll vote for me. Also this: They are terrified that their opponent is closer to being that "regular guy" and that can't happen.
So you end up with John Kerry and "Lambert Field" and stories of his favorite Sox player, Eddie Yost (who never played for the Red Sox) and "Manny Ortez," and Joe Biden telling a crowd in San Francisco that the Giants were going to the Super Bowl, confused that there was a Giants team in both New York and San Francisco, Martha Coakley calling out Curt Schilling as a "Yankees fan," Newt Gingrich talking about watching "watching college championship basketball" (again, what real sports fan uses language like that?) in a January debate and Elizabeth Warren not knowing what years the Sox won the World Series and Obama, who the media has breathlessly told us is a die-hard White Sox fan, not able to tell Rob Dibble the name of one White Sox player he admired growing up.
(Obama's defense was that he was an A's fan as a kid and became a White Sox fan when he moved to Chicago, which is a perfect answer for a politician but an indictment if you are an actual sports fan. Who the hell casually changes loyalty like that? People with no investment, of course.)
Which is fine. I don't care if Obama or Romney or Paul Ryan (who compared the NFL replacement officials to the Obama Administration last week, and yes it was as clunky as it sounds) or Biden or Warren or Brown or Menino (beyond parody) watch or care about sports. And I don't know anyone who cares, either. They just want competent, honest people who can fix a disastrous economy, avoid unnecessary wars, make sure we can afford to send our kids to college, maybe keep gas under $4 a gallon.
Worry about that for the next 32 days, OK? When you are asked about Bobby Valentine or a college playoff system or Tim Tebow or the Miami Heat or the World Series or anything else that has anything to do with sports just politely decline to comment. Tell whoever is asking that there is an election a month away, and real issues to discuss. Tell them that there is no reason to insult the intelligence of voters by wasting their time with opinions that would be half-informed at best and tell them that a good voter wouldn't and shouldn't care, just as a good voter wouldn't and shouldn't care which candidate John Elway or Jack Nicklaus or Bob Cousy or any celebrity is endorsing. If you are voting for someone because John Elway -- who is famous for being able to throw a ball -- thinks it would be best it might be time to give up the privilege.
But none of this will happen. I guarantee, over the next 32 days, one of these candidates will say something about sports that will be mocked, that will confirm what we already knew, that will prove what happens when you mix massive insecurity with the desire to be liked plus that inability to admit that you might not know everything.
Just ask Mike McGwire and Sammy Sooser.
Dale, Michael and Jerry dig into the details of this draft for the Patriots with ESPN's Mike Reiss.
Giardi and Price discuss the Tom Brady appeal getting overturned and Roger Goodell's victory tour. The guys can't believe the victory lap and some of his behavior. The more you listen to him, the more frustrating his behavior becomes.
Giardi and Price break down how the teams in the AFC East altered their futures after the NFL Draft weekend.
Danny Ainge joins Glenn and Christian to explain the Celtics draft process; and he also discusses the trade rumors that permeated the night.
Mut is flying solo the last hour, but he's giving reaction and analysis as the Celtics draft a power forward out of France by the name of Guerschon Yabusele and getting some early grades for the Celtics
Mut and Kirk are talking more about the Celtics pick of Jaylen Brown and can't seem to find anyone who thinks it's a good pick or can make a case for why the Celtics took him third overall.
Christian recaps the Red Sox 6-2 loss to the Rangers.
Joe, Tim, and Lou talk with Red Sox shortstop Xander Bogaerts after his walk-off RBI single propelled the Red Sox past the White Sox 8-7.
Mut recaps the Red Sox 8-6 loss to the White Sox.
DJ and Pete continue to assess the season that was for the Bruins and look toward the future for the franchise and how they can improve.
DJ and Pete are together for the final Sunday Skate of the season. They get into their overall thoughts on the season, the Bruins keeping Claude Julien on as head coach and the end-of-season press conferences last week. They discuss the rebuild process, what the Bruins need and how they can obtain it. Plenty of callers have their own theories and opinions on all of these topics as well.
Butch is joined by two-thirds of the Sunday Skate show in DJ and Pete. The guys discuss the problems with Bruins including leadership and grit, who should stay and who should go and if Claude is to blame.
Who would you like to see in Dino's chair, Gary or Mut?
The debate heats up as the discussion turns towards O.J. Simpson
On a Friday edition of Headlines, Gary presents us with some thrilling erotica talk.
Danny Ainge joins Glenn and Christian to explain the Celtics draft process; and he also discusses the trade rumors that permeated the night.
Jackie MacMullen talks about Jaylen Brown, the Celtics thought process, and what may happen in Free Agency.
Glenn and Christian discuss last night's underwhelming draft by the Celtics
Dale Holley and Thornton talk NBA draft.
Dale and Holley's Final Drive 06-24-16
Laroy Streat comes back at it again! Talking the Celtics Draft and his take on the Celtics 3rd Draft pick. Catch Laroy every friday with the Dale & Holley Show 5:45- 6PM.
Former Celtics General Manager Jan Volk joins Kirk Minihane for a discussion that any Celtics fan will love. Kirk and Jan talk about the legendary 85/86 Celtics and how the team was constructed and of course the decision to draft Len Bias and his tragic death.
Kirk Minihane sits down with John Tomase to talk about the current political landscape, John's desire to write about social issues, and of course Spygate is discussed.
Kirk Minihane is joined by one of his radio heroes, Artie Lange. They discuss everything from Artie's comedy career, his time with Howard Stern, his issues with drugs and prostitutes, and the comedy show to benefit slain Officer Ronald Tarentino Jr.
Ben, Russ & Alex recap the 4-0 loss the USMNT suffered to Argentina in the COPA America Centenario semifinal. Then they catch up with the EURO's, and recap if their predicted winners are still in the tournament.
Former Celtics General Manager Jan Volk joins Kirk Minihane for a discussion that any Celtics fan will love. Kirk and Jan talk about the legendary 85/86 Celtics and how the team was constructed and of course the decision to draft Len Bias and his tragic death.
This week we look back at the US Open.
Dale Holley and Thornton talk NBA draft.More from this show
Jackie MacMullen talks about Jaylen Brown, the Celtics thought process, and what may happen in Free Agency.More from this show
Danny Ainge joins Glenn and Christian to explain the Celtics draft process; and he also discusses the trade rumors that permeated the night.More from this show
Who would you like to see in Dino's chair, Gary or Mut?More from this show
The moody and opinionated Kirk Minihane stops by the station with Bradford and MLB.com's Ian Browne live in Arlington. Kirk, Rob and Ian discuss anything and everything.More from this show


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Based on the tweets and responses from NFL personnel, LSU's 2014 pro day was another successful event. Zach Mettenberger may be the big winner as many ESPN analysts like Ron Jaworski and Merrill Hoge say the former Tiger signal caller might be the best pro prospect not chosen in the 1st round. Continue reading
LSU Official Page
- Walker to be Inducted into Omaha HOF SundayThree of the greatest players and one of the greatest coaches ever to participate in the College World Series will be inducted into the Omaha College Baseball Hall of Fame July 3 in Omaha, Neb.
- Road To Rio Arrives at Jamaican TrialsBATON ROUGE – The next stop on the Road To Rio for members of the LSU Track & Field program is Kingston, Jamaica, as 10 current and former athletes are set to compete for a spot on Jamaica's Olympic Team at the 2016 Jamaican Senior Championships beginning Thursday and running through Sunday at the National […]
- LSU Athletes' Journey to the Rio de Janeiro OlympicsA list of current and former LSU student-athletes who are competing for a shot at the 2016 Olympic games in Rio de Janeiro, and the trials in which they are competing.
- SEC Announces Spring Academic HonorsBATON ROUGE, La. – On Wednesday, the 2016 Southeastern Conference Spring Honor Roll was released, as LSU had 62 student-athletes were honored for their work in the classroom over the course of the last year.
- Chapman Named to Canada's Olympic Soccer TeamBATON ROUGE – Allysha Chapman made history a season ago as the first LSU Tiger to play at the FIFA Women's World Cup, and she will make history once again in Rio de Janeiro, Brazil, this summer as the program's first Olympian after being named by head coach John Herdman to Canada's 18-player squad for […]
- Walker to be Inducted into Omaha HOF Sunday
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Hello, Staying in Santiago for a few days this November. Upon arrival to the airport i booked a car at the Alamo. One of the days im planing to make a trip to Casablanca Valley to Valparaiso to Vina del Mar. Have a few questions.
How safe is it picking up a car from SCL and going into Santiago?
Will i have any issues making a day trip to Casablanca Valley to Valparaiso to Vina del Mar.
How hard is the road?
Will signs and tolls on the road be an issue along the way for someone who does not speak Spanish?
Any tips?
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Santiago to Casablanca Valley to Valparaiso to Vina del Mar
Hello, Staying in Santiago for a few days this November. Upon arrival to the airport i booked a car at the Alamo. One of the days im planing to make a trip to Casablanca Valley to Valparaiso to Vina del Mar. Have a few questions.
Report Abuse
Firstly, I would change the booking with Alamo if you haven't paid anything yet. It gets far too many complaints. If you are not able to change, then demand a refund if they do not provide the car they promised at the price agreed. Check the car carefully for damage, working lights etc. and take photos if possible.
A car is not necessary in the city of Santiago and may complicate you more than help, unless you are doing excursions outside the city. There is a good metro system and taxis are not expensive.
Your rental car should come equipped with a TAG, an electronic device, which will beep under portals on the urban highways. On the road to the coast you will have tolls. The price is clearly marked by each booth. It is more expensive on weekends. You just hand the girl some money and she will give you your change and a receipt. You don't need to speak Spanish. The road is excellent. On the highway brown signs are informational and will indicate vineyards etc. If you pass something by mistake, look for RETORNO, a place you can double back.
Parking in Valparaíso is a very difficult, and in Viña to a lesser degree. Parking in either in February is a challenge. You may have to leave the car a fair way away. Be prepared to walk and don't leave anything in the car. There are a lot of one way streets, curves and hills in Valparaíso.
If you are staying at least a night in Valparaíso or Viña and want to stop at the vineyards then a car is useful going and returning. But the drink driving laws are much stricter in Chile than the US or Europe, so don't taste and drive.
One possibility is to get a private tour of the Casablanca valley with a drop off in Valparaíso and return on the bus.
Report Abuse
My daughter and I did a version of this trip last year. We did a couple days in Santiago using public transportation and then went back to the airport to pick up our car(AVIS). I did the driving out to Vina del Mar where we stayed while doing a day trip to Valparaiso and around. The roads are great and the expressway is actually cut through some mountains on the way out there.Keep in mind that alot of Valpariso and Vina del Mar are vertical so some roads are quite tricky...just saying!
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Airbus a380
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- DULLES, Va. – Emirates airline showed off its Airbus A380 superjumbo earlier this week at Washington Dulles International Airport.
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Interestingly, a new twist on an alternative revenue generator has emerged: the democratized digital tip jar. Sites like Wikipedia have employed an online tip jar for years in the form of regular requests for donations from its users via PayPal, credit/debit cards, and other payment methods. But now a major player in the digital donations space-Flattr-is partnering with AdBlock Plus to offer Flattr Plus, a browser extension/app that enables users to remove online ads from sites they visit while also contributing a monthly payment in an amount they choose that will be distributed proportionally to publishers of the sites they surf.
Nov 02, 2004
iMarkup Solutions, a provider of Web-based document management and collaboration tools, has announced a technology partnership with Stellent, Inc., a provider of content management solutions. The companies are also announcing the integration of the iMarkup Java Annotation SDK with Stellent Universal Content Management.


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24 June 2016 12:59 PM, PDT | Uinterview | See recent Uinterview news »
Luke Evans went with a rugged look on the grounds of the Glastonbury Festival at Worthy Farm, Pilton in England on Friday. Luke Evans' Latest Look Evans has been taking in the concerts at England's Glastonbury festival in style. On Friday, the Welsh actor donned pieces from the Coach Mens 2016 line, including a red […]
The post Luke Evans Wears Coach At Glastonbury appeared first on uInterview. »
- Chelsea Regan
23 June 2016 5:46 PM, PDT | WeAreMovieGeeks.com | See recent WeAreMovieGeeks.com news »
Playing now in theatres, on Demand, on Amazon Video and on iTunes, watch Portishead's music video cover of Abba's 'Sos' as heard in High-rise.
High-rise is the latest film by cult British director Ben Wheatley (Kill List, A Field in England), an ambitious adaptation of the J.G. Ballard novel of the same name.
The film stars Tom Hiddleston, Jeremy Irons, Sienna Miller, Luke Evans and Elisabeth Moss.
High-rise stars Hiddleston as Dr. Robert Laing, the newest resident of a luxurious apartment in a high-tech concrete skyscraper whose lofty location places him amongst the upper class.
Laing quickly settles into high society life and meets the building's eccentric tenants: Charlotte (Miller), his upstairs neighbor and bohemian single mother; Wilder (Evans), a charismatic documentarian who lives with his pregnant wife Helen (Moss); and Mr. Royal (Irons), the enigmatic architect who designed the building.
Life seems like paradise to the solitude-seeking Laing. »
- Michelle McCue
22 June 2016 6:36 PM, PDT | MovieWeb | See recent MovieWeb news »
When Universal Pictures started their Monster Universe a few years ago, there had been talk of several different classic projects getting rebooted. Dracula Untold became the first installment in this franchise, after a post-credit scene featured Luke Evans' title character showed him emerging in present day. The Mummy reboot will be next out of the gate, hitting theaters next June. But we aren't sure which project is moving forward next. Today we have word that the studio wants Dwayne Johnson to star in their modern update of The Wolf Man.
Buried within Deadline's report about Dwayne Johnson setting up another project at Sony entitled Son of Shaolin, the site claims there are "persistent rumors" that Universal wants the actor to portray the title character, although it isn't clear when that project may get off the ground. If it's far enough down the line, it's possible that Dwayne Johnson may »
- MovieWeb
15 June 2016 8:22 PM, PDT | LatinoReview | See recent LatinoReview news »
That's right, the story of the twenty-year battle to remake The Crow hasn't reached its end yet. This is a film that's been a revolving door of talent. On the long list of actors who took up the lead of this film at one point or another are Luke Evans, Tom Hiddleston, Bradley Cooper, and Jack Huston. The movie has also had a good handful of directors enter and exit the project over the course of its failed development.
The latest of these directors was Corin Hardy, who was reportedly fired from the project in March of this year. This led to legal action taken by the film's producer Ed Pressman, who gave Relativity rights to sequels, and by firing Hardy without his consultation, they had supposedly violated their agreement. There's been no real word since March about this legal battle.
Now, in a throwaway line from a recent Deadline report, »
- Joseph Medina
14 June 2016 3:15 PM, PDT | DailyDead | See recent DailyDead news »
Based on J.G. Ballard's brilliant novel of the same name, Ben Wheatley's High-Rise stars Tom Hiddleston as Dr. Robert Laing, who discovers a new way of life after moving into a skyscraper packed with peculiar characters. If you missed High-Rise in theaters, don't despair, because Magnolia Home Entertainment will give the film a Blu-ray / DVD release this summer.
High-Rise is scheduled to come out on Blu-ray and DVD on August 2nd. Special features and official cover art have yet to be revealed, but we'll keep Daily Dead readers updated on further announcements. In case you missed it, check out Heather's review of Ben Wheatley's latest film:
Synopsis: "High-rise stars Tom Hiddleston (The Avengers) as Dr. Robert Laing, the newest resident of a luxurious apartment in a high-tech concrete skyscraper whose lofty location places him amongst the upper class. Laing quickly settles into high society life and meets the building's eccentric tenants: Charlotte (Golden Globe® nominee Sienna Miller, American Sniper), his upstairs neighbor and bohemian single mother; Wilder (Luke Evans, Beauty and the Beast), a charismatic documentarian who lives with his pregnant wife Helen (Golden Globe winner Elisabeth Moss, "Mad Men"); and Mr. Royal (Academy Award® winner Jeremy Irons, Batman v Superman: Dawn of Justice), the enigmatic architect who designed the building. Life seems like paradise to the solitude-seeking Laing. But as power outages become more frequent and building flaws emerge, particularly on the lower floors, the regimented social strata begins to crumble and the building becomes a battlefield in a literal class war."
The post Ben Wheatley's High-rise to be Released on Blu-ray / DVD this August appeared first on Daily Dead. »
- Derek Anderson
9 June 2016 4:00 AM, PDT | E! Online | See recent E! Online news »
We cannot wait to see what Disney does with their new live-action adaptation of Beauty and the Beast. The much buzzed about production, directed by Chicago director Bill Condon, stars Emma Watson as Belle, Downton Abbey's Dan Stevens as Beast, Luke Evans as Gaston and Josh Gad as Le Fou. The star-studded cast also includes Ewan McGregor, Sir Ian McKellan, Emma Thompson, Stanley Tucci and so many more. Gugu Mbatha-Raw plays Plumette. "I do [sing]. It's so exciting," Mbatha-Raw told me while promoting the new Civil War drama Free State of Jones (in theaters on June 23), adding, "A lot of my character is animated so I was only on set a couple of days. But, they were magical days. I mean, we »
27 May 2016 1:01 PM, PDT | Dark Horizons | See recent Dark Horizons news »
He's been rumored for so long now that it won't be truly official until Eon and MGM make an announcement or issue a press release. Even so, more and more evidence is building that Tom Hiddleston is being lined up to take on the role of James Bond.
Birth Movies Death today reports that the actor is in 'advanced negotiations' to play the British super spy, citing "sources close to" the actor himself. Hiddleston has not been shy about actually wanting to play the role, but with comments indicating that there's no preliminary movement on the next film in the franchise planned until the end of the year at the earliest, all this could easily just be what's dubbed "negotiating in the press".
Rumors of Daniel Craig's recasting have hit fever pitch in recent months with Hiddleston seemingly cited every other day while the likes of Idris Elba, Aidan Turner, »
- Garth Franklin
26 May 2016 1:18 PM, PDT | Flickeringmyth | See recent Flickeringmyth news »
It looks like Disney has another sure-fire hit on its hands with Beauty and the Beast, with this week's first teaser trailer for the upcoming live-action adaptation setting a new record for the most views in 24 hours.
Following its debut on Good Morning America, the trailer racked up 91.8 million views in its first day, smashing the previous record of 88 million views set by Star Wars: The Force Awakens and also outpacing Marvel's big offerings Captain America: Civil War (61 million) and Avengers: Age of Ultron (34 million).
It should be noted that the figures only include teaser trailers, and the record for the most viewed trailer still belongs to Star Wars: The Force Awakens, with its October trailer last year generating a whopping 128 million views in 24 hours.
Disney's "Beauty and the Beast" is a live-action re-telling of the studio's animated classic which refashions the classic characters from the »
- Gary Collinson
24 May 2016 5:13 PM, PDT | MovieWeb | See recent MovieWeb news »
Back in April, Disney and LucasFilm unveiled the second teaser for Star Wars: The Force Awakens, during Star Wars Celebration in Anaheim. The online release of this highly-anticipated footage set a new record, with 88 million views within the first 24 hours of release. Some thought that record wouldn't fall until perhaps the first footage from Star Wars: Episode VIII was released, but today we have word that this record has fallen, by another upcoming Disney movie. Yesterday, the first teaser for Beauty and the Beast debuted, which was viewed a record 91.8 million times.
The Hollywood Reporter reveals that the live-action Beauty and the Beast footage broke the record for the most-viewed "teaser" within the first 24 hours. The 91.8 million mark bested the April teaser for Star Wars: The Force Awakens, the first teaser for Captain America: Civil War (61 million views) and Avengers: Age of Ultron (31 million). Still, another trailer record set by »
- MovieWeb
24 May 2016 8:27 AM, PDT | AreYouScreening.com | See recent AreYouScreening news »
So, you're Disney, you have a property that's made you kajillions of dollars already, and the related toy/park merchandise sales aren't exactly dropping off, but you think you can throw out something else that will make you tons more money… might want to jump on that one, right?
The animated Beauty and the Beast was rather a while ago in cinematic terms, and while you can put out a new edition of the Blu-Ray every couple of years, there's nothing like getting things fresh in people's minds again. Plus, you could get a lot of big names involved, and your test run, Into the Woods, did even better than you hoped.
Oh sure, it's probably actually going to be a good movie, and that's even more likely when you know that Bill Condon is directing, but there's just got to be »
- Marc Eastman
23 May 2016 8:17 PM, PDT | WeAreMovieGeeks.com | See recent WeAreMovieGeeks.com news »
Emma Watson is Belle in the lovely trailer for Beauty And The Beast.
Disney's Beauty And The Beast is a live-action re-telling of the studio's animated classic which refashions the classic characters from the tale as old as time for a contemporary audience, staying true to the original music while updating the score with several new songs.
Beauty And The Beast is the fantastic journey of Belle, a bright, beautiful and independent young woman who is taken prisoner by a beast in his castle. Despite her fears, she befriends the castle's enchanted staff and learns to look beyond the Beast's hideous exterior and realize the kind heart and soul of the true Prince within.
The film stars: Emma Watson as Belle; Dan Stevens as the Beast; Luke Evans as Gaston, the handsome, but shallow villager who woos Belle; Oscar winner Kevin Kline as Maurice, Belle's eccentric, »
- Michelle McCue
23 May 2016 3:55 PM, PDT | Hitfix | See recent Hitfix news »
Bill Condon was an inspired choice by Disney for the live-action version of Beauty and the Beast. After all, there are few people I know who have a more exhaustive knowledge of musicals, both onscreen and on the stage, and he takes the form seriously. He isn't afraid to call the sacred cows out when he disagrees, and he cares deeply about how these properties are adapted to the bigscreen. When he was working on Dreamgirls, he was incredibly happy, and there's a joy to that filmmaking as well as a knowledge of the way musicals typically do or don't work onscreen. Disney's committed to turning every animated film they've ever made into a live-action film, although I'm not sure how you define that term anymore. Is Alice Through The Looking Glass a live-action film? Is Pete's Dragon a live-action film? Is Warcraft a live-action film? »
- Drew McWeeny
23 May 2016 2:17 PM, PDT | ShockYa | See recent ShockYa news »
Disney's "Beauty and the Beast" is a live-action re-telling of the studio's animated classic which refashions the classic characters from the tale as old as time for a contemporary audience, staying true to the original music while updating the score with several new songs. "Beauty and the Beast" is the fantastic journey of Belle, a bright, beautiful and independent young woman who is taken prisoner by a beast in his castle. Despite her fears, she befriends the castle's enchanted staff and learns to look beyond the Beast's hideous exterior and realize the kind heart and soul of the true Prince within. The film stars Emma Watson, Dan Stevens, Luke Evans, [ Read More ]
The post Disney's Beauty and the Beast Gets A New Teaser appeared first on Shockya.com. »
- Rudie Obias
23 May 2016 1:00 PM, PDT | Movies.com | See recent Movies.com news »
Due out next March 17, Disney looks to continue their run of wild success when it comes to live-action adaptations of their popular classics by sending out a new version of Beauty and the Beast, starring Emma Watson as Belle and Dan Stevens as the Beast. The first teaser has just hit, and while it doesn't give us a look at the Beast or a few of the story's other colorful and memorable characters (like Lumiere, played by Ewan McGregor, or Gaston, played by Luke Evans), we do get to glimpse Belle as well as hear a tiny bit of that classic music. Check it out. Obviously they're holding back a lot here, including looks at many of the characters. Plus, we're itching to see what the new Beast looks like and, of course, that moment when Belle and Beast are...
Read More
- Erik Davis
23 May 2016 9:42 AM, PDT | firstshowing.net | See recent FirstShowing.net news »
Be our guest! Disney has debuted the first teaser trailer for the new live-action version of the classic story of Beauty and the Beast, starring Emma Watson as Belle. Dan Stevens stars as the Beast, who isn't seen at all in this footage. Is he under make-up or CGI? The cast includes Luke Evans as Gaston, Kevin Kline as Maurice, Josh Gad as Lefou, Ewan McGregor as Lumiere, Stanley Tucci as Maestro Cadenza, Gugu Mbatha-Raw as Plumette, Audra McDonald as Madame Garderobe, Ian McKellen as Cogsworth, and Emma Thompson as Mrs. Potts. The film will include new recordings of the original songs written by Alan Menken and Howard Ashman, as well as several new songs written by Menken and Tim Rice. Have a look. Here's the first teaser trailer for Bill Condon's Beauty and the Beast, from Disney's YouTube: Disney's Beauty and the Beast is a live-action re-telling »
- Alex Billington
23 May 2016 7:41 AM, PDT | Variety - Film News | See recent Variety - Film News news »
Disney has released the first trailer for its live-action "Beauty and the Beast" with just a glimpse of Emma Watson as Belle arriving at the Beast's castle, saying "Hello?" and reaching for a rose.
The teaser was unveiled on "Good Morning America," 10 months ahead of the film's release, with a snippet of dialogue from Ewan McGregor's Lumiere ("Look, it's a girl! …What if she's the one?") and a delicate piano version of the movie's iconic music.
Bill Condon is directing with David Hoberman and Todd Lieberman of Mandeville Films producing. The script was written by Evan Spiliotopoulos and rewritten by Stephen Chbosky.
Alan Menken, who won two Oscars for the 1991 animated version of "Beauty and the Beast," will score the new film, which will include new recordings of the original songs in addition to new songs written by Menken and Tim Rice.
The cast includes Dan Stevens as Beast, »
- Dave McNary
23 May 2016 7:02 AM, PDT | Dark Horizons | See recent Dark Horizons news »
Following its premiere on "Good Morning America," Walt Disney Pictures has revealed the trailer for the Bill Condon-directed new live-action adaptaion of their 1991 animated favorite "Beauty and the Beast" which opens March 17th 2017.
The film includes Emma Watson as Belle, Dan Stevens as Beast, Ian McKellen as Cogsworth, Luke Evans as Gaston, Josh Gad as LeFou, Kevin Kline as Maurice, Emma Thompson as Mrs. Potts, Gugu Mbatha-Raw as Plumette, Ewan McGregor as Lumiere, and Stanley Tucci as Cadenza.
- Garth Franklin
23 May 2016 6:40 AM, PDT | MovieWeb | See recent MovieWeb news »
The first sneak peek at Disney's upcoming live-action re-telling of Beauty and the Beast is here. Giving audiences a glimpse at the highly anticipated film based on the animated classic which refashions the iconic characters and musical numbers from the tale as old as time, the film stars Emma Watson, Dan Stevens, Luke Evans, Kevin Kline, Josh Gad, Ewan McGregor, Stanley Tucci, Ian McKellen and Emma Thompson. Beauty and the Beast opens in U.S. theaters on March 17, 2017.
Made for a contemporary audience, this latest Disney fairy tale stays true to the original music while updating the score with several new songs. Beauty and the Beast is the fantastic journey of Belle, a bright, beautiful and independent young woman who is taken prisoner by a beast in his castle. Despite her fears, she befriends the castle's enchanted staff and learns to look beyond the Beast's hideous exterior and realize the »
- MovieWeb
23 May 2016 6:22 AM, PDT | Cinelinx | See recent Cinelinx news »
This morning sees the debut of the Beauty and the Beast live-action teaser trailer, and...well, it's something. Come inside to check it out!
While I'm not the biggest fairy tale movie fan (not even a little bit), I can't deny that Disney's live-action retelling of their classic stories have been impressively handled. As such, I've found myself more interested in the upcoming Beauty and the Beast adaptation than I would have thought. So it's a bummer that this first teaser doesn't give us much to work with:
I'm not saying it's a bad trailer. I can't. The truth is, there doesn't seem to be enough here to judge whether or not it's good or bad as a trailer. The sets look great, and the music is neat, of course, but eager fans see next to nothing. I get why we wouldn't see the Beast just yet. Being that he'll »
- firstname.lastname@example.com (Jordan Maison)
23 May 2016 6:20 AM, PDT | PEOPLE.com | See recent PEOPLE.com news »
A beauty but a funny girl, that Belle! The first Beauty and the Beast teaser trailer is here, finally giving Disney fans a peek at Emma Watson in her role as Belle. While there's no yellow ballgown in sight, Watson does make a brief appearance at the end of the clip, peering at the fairy tale's iconic rose. The teaser shows the Beast's dilapidated mansion, and includes a brief voice-over conversation between Ewan McGregor as Lumiere and Ian McKellen as Cogsworth. "Look, a girl," remarks Lumiere, the candelabra. "Yes, I can see it's a girl you fool," Cogsworth, the clock, »
- Lindsay Kimble, @lekimble
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Following the journey of a dachshund as it is shuffled from owner to owner, Todd Solondz's Wiener-Dog is one of his sharpest visions of futility.
Following the journey of a dachshund as it is shuffled from owner to owner, Todd Solondz's Wiener-Dog is one of his sharpest visions of futility.
It's just dull and hollow—a massive waste of time and money.
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
Ken Loach's "I, Daniel Blake" wins the Palme d'Or at the 69th Cannes Film Festival.
Barbara Scharres on the cats of Cannes 2016.
An article about Roger Ebert's reviews getting republished in the Chicago Sun-Times.
Chaz Ebert remembers the late Paul Cox and shares an article about Cox speaking with students at the 2009 Cannes Film Festival.
A report by FFC Seongyong Cho about Andrew Ahn's "Spa Night," which recently played the Jeonju International Film Festival.
FFC Gerardo Valero returns to "The Shawshank Redemption" to investigate how it remains the #1 film on IMDb.
A book review of "The Art & Making of Independence Day: Resurgence."
An interview with the directors of "Swiss Army Man."
* This filmography is not intended to be a comprehensive list of this artist's work. Instead it reflects the films this person has been involved with that have been reviewed on this site.
Just think: Johnny Depp could have had the career of, say, Richard Grieco. In 1988, they were both break-out stars, young TV cops working undercover as high school students in the fledgling Fox network's first hit show, "21 Jump Street."


text:
- THE BUZZ: Tenement Tenting
- MUSIC BOX: Wyoming Songwriters Highjacked
- GET OUT: Icy Heat
- GUEST OPINION: Build it for Piper
- THE FOODIE FILES: Taste the Wild Side
- FEATURE: Turning Away from the Ledge
- Grizzly End for 399's Cub
- Tapia's Death No Longer Classified Suspicious
- FEATURE: Summer of Jams
- THE BUZZ 2: Priority Pass
Powder Puff is a Bore
The Powder Puff football game sounds like a good idea, but in reality is quite a bore. The game took place on 10/5/11. I dropped in for about 20 minutes to see what was up. I imagine that the girls got a kick out of preparing for the game, planning what socks they were going to wear and how they were going to do their hair. Some of the kids were good athletes. The problem is that football is a complicated game that is difficult to play. Watching people play it who don't understand it or love it is quite drab, and I'm not sure it was a whole lot of fun for the Powder Puffs. I would have much preferred to watch them play a game that they really new how to play. Maybe soccer. Also, the apropos, but still disturbing guys in drag half time show was embarrassing. It seems some guys will take any opportunity to dress in drag. Let's get together as a community and limit those opportunities – Please. This means you, too, Kiwanis.


text:
BRP US Inc. has announced the Evinrude E-TEC "Experience More" Boat Show Sales Event for customers in the United States.
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Maritime Today
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Klüber Lubrication, manufacturer of specialty lubricants, provides high-performance gear oils that are based on high-grade raw materials and advanced additives,
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A 984-foot Chinese container ship was greeted with fireworks and cheers from a crowd that had gathered, when it made an inaugural passage through the newly expanded Panama Canal on Sunday,
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United Nations International Maritime Organization (IMO) Secretary- General Ki Tack Lim pushed for the increased involvement of women in the seafaring industry
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I once asked an old, tired-looking black man to play James P. Johnson's "Snowy Morning Blues" and he obliged after first turning around to take a better look at me. That tune was written in New York in 1920s and recorded a couple of times by Johnson himself and a few others. Its name already sets up a scene in one's imagination. Someone has woken late, drawn open the curtains and found the rooftops and streets covered with snow. It must be a Sunday, because the tune evokes the melancholy and the quiet joy of someone lounging around, reminiscing about the night before. That mixture of emotions is the quality of all the best pop and jazz tunes. If they were only sad, or only happy, they would grow tiresome after a while. Was it Al Capone who expressed the opinion that jazz was better than opera, because it didn't just go around slobbering? –"Reminiscing About the Night Before," by Charles Simic, NYRblog
I spotted a worn copy of The Female Eunuch on my mother's shelf in 1999, and something about the savage cover, showing a hollow female torso with handles hanging from a clothes-rail, seemed to whisper a wealth of dangerous secrets. Like a grimoire in a fairytale, I felt drawn to the book, somehow compelled by it. Leafing through the yellowing pages I realised, with the righteous rage that only a preteen can summon, that I had been lied to. There were other ways of looking at the world. There was more to sex than the sterile, ritualised commercial play my classmates were already rehearsing, more to femininity than the smiling servitude that made my mother and grandmother so unhappy. In later life, I would come to understand this process as consciousness-raising; at the time, it felt like a striplight had been switched on in my mind. –"The Female Eunuch 40 years on," by Laurie Penny, the Guardian
A trove of photos from the creator of Subway Art, Spray Can Art, and Style Wars, The agonies of Ikea shelving and record obsession, and an audiobook of Neil Postman's iconic TV critique Amusing Ourselves to Death
In the papers some have accused me of giving 'hate-speeches', of wanting India to break up. On the contrary, what I say comes from love and pride. It comes from not wanting people to be killed, raped, imprisoned or have their finger-nails pulled out in order to force them to say they are Indians. It comes from wanting to live in a society that is striving to be a just one. Pity the nation that has to silence its writers for speaking their minds. Pity the nation that needs to jail those who ask for justice, while communal killers, mass murderers, corporate scamsters, looters, rapists, and those who prey on the poorest of the poor, roam free. –"I pity the nation that needs to jail those who ask for justice," by Arundhati Roy, The Times of India
More from gabriel:
i. stand with israel
I listen to a lot of conservative talk radio. Confident masculine voices telling me the enemy is everywhere and victory is near — I often find it affirming: there's a reason I don't think that way. Last spring, many right-wing commentators made much of a Bloomberg poll that asked Americans, "Are you more sympathetic to Netanyahu or Obama?" Republicans picked the Israeli prime minister over their own president, 67 to 16 percent. There was a lot of affected shock that things had come to this. Rush Limbaugh said of Netanyahu that he wished "we had this kind of forceful moral, ethical clarity leading our own country"; Mark Levin described him as "the leader of the free world." For a few days there I yelled quite a bit in my car.
The one conservative radio show I do find myself enjoying is hosted by Dennis Prager. At the Thanksgiving dinner of American radio personalities (Limbaugh is your jittery brother-in-law, Michael Savage is your racist uncle, Hugh Hewitt is Hugh Hewitt) Dennis Prager is the turkey-carving patriarch trying to keep the conversation moderately high-minded. While Prager obviously doesn't like liberals — "The gaps between the left and right on almost every issue that matters are in fact unbridgeable," he has said — he often invites them onto his show for debate, which is rare among right-wing hosts. Yet his gently exasperated take on the Obama–Netanyahu matchup was among the least charitable: "Those who do not confront evil resent those who do."
Average number of Americans who are injured by chain saws each year:
National Safety Council (Chicago)
A farmer in Kenya bit a python who tried to eat him.
A former prison in Philadelphia that has served as a horror-movie set was being prepared as a detention center for protesters arrested at the upcoming Democratic National Convention, and presumptive Republican presidential nominee Donald Trump fired his campaign manager.
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"Matt was happy enough to sustain himself on the detritus of a world he saw as careening toward self-destruction, and equally happy to scam a government he despised. 'I'm glad everyone's so wasteful,' he told me. 'It supports my lifestyle.'"


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Brit Marling joins Oscar-nommed Hailee Steinfeld in dramatic thriller
April 25, 2013 - 16:45 AMT
PanARMENIAN.Net -
Brit Marling is in final negotiations to star in an untitled dramatic thriller formerly known as "The Keeping Room" that Daniel Barber is directing from a script by up-and-coming screenwriter Julia Hart, TheWrap said.
Wind Dancer Films, Gilbert Films and Anonymous Content are producing the film, which will co-star Hailee Steinfeld ("True Grit") and Nicole Beharie ("Shame").
Olivia Wilde was originally attached to star but she is no longer involved with the project.
Hart's script, which appeared on the 2012 Black List of Hollywood's best unproduced screenplays, follows three Southern women -- two sisters and one African American slave -- who are forced to defend their home from a band of civil war soldiers who have broken off from the fast approaching Union Army.
Jordan Horowitz of Gilbert Films will produce with Judd Payne, Matt Williams, David McFadzean and Dete Meserve of Wind Dancer Films. Gary Gilbert will executive produce with Michael Sugar of Anonymous Content, whose Nicole Romano and Trevor Adley will co-produce.
Marling can currently be seen in Robert Redford's political thriller "The Company You Keep," and she next stars in Fox Searchlight's thriller "The East," which reunites her with "Sound of Your Voice" director Zal Batmanglij. Marling's other credits include "Another Earth" and "Arbitrage."
Top stories
The film will add to awareness as it looks at eyewitness testimonies recorded in the 1980s to help understand the severity of the tragedy.
Already included in the List of the Intangible Cultural Heritage of Humanity are the Duduk, Armenian khachkar, lavash,"David of Sassoun."
She joins an impressive group of fashion moguls on the list that includes Spanx founder Sara Blakely and bridal tycoon Vera Wang.
It's only the second movie of 2016 to cross the 10-figure threshold, the other being fellow Disney title "Captain America: Civil War."
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"Now You See Me 2" conjures record-smashing opening in China The cast includes Jesse Eisenberg, Mark Ruffalo, Woody Harrelson and Dave Franco and Daniel Radcliffe, among others.
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text:
Shades of Grey
An amnesiac man finds himself fighting to bring color to a B&W world.
Bad Guys
Hey! Bad guys coming!
Robots in Ancient Greece
What would happen if robots went back in time to ancient Greece?
Don't mind me, just revisiting some history.
Like the others, this is funny, beautiful, and overall great. Awesome job, dude!
Dude, I've been looking at all the episodes since I was a kid and you do a very awesome job animating. It's like you have a very wonderful imagination. I wish you can make more episodes because it's very beautiful and probably inspires me to animate stuff. Keep up the great work.
Very nicely animated.


text:
Nike Women's Air Zoom Fly 2 Running Shoe Reviews
Rated 4.7 out of 5 by 96reviewers.
Rated 5 out of 5 by GreenLady LOVE THESE SHOES !! Great shoes. LOVE the colors and the fit ! Wear them for Zumba and/or walking since I'm not a runner. Fit is perfect and the shoes feel so comfortable. June 18, 2016
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|Publication number
|Publication type
|Application number
|Publication date
|Jul 5, 1994
|Filing date
|Jan 10, 1991
|Priority date
|Jan 12, 1990
|Fee status
|Also published as
|Publication number
|Annouk Rozier
|Original Assignee
|Merck Sharp & Dohme-Chibret
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (1), Non-Patent Citations (2), Referenced by (17), Classifications (23), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to a fluid ophthalmic composition.
Many ophthalmic compositions are currently available in liquid or solid form, but none of them is, in fact, completely satisfactory.
In effect, liquid ophthalmic compositions, although easy to use, have some drawbacks; in particular, it is difficult to obtain a sustained or delayed action of the active principle which they contain.
Similarly solid or semi-solid ophthalmic compositions which, for their part, permit a longer-lasting action of the active principle, are not liked by the users on account of their method of application. In effect, they are presented in the form of a solid insert or an ointment to be introduced into the conjunctival cul-de-sac.
The present invention relates to a fluid ophthalmic composition which is easy to use, enabling the availability of the active principle to be improved, especially as a result of high intraocular levels.
The present invention proposes a fluid ophthalmic composition, characterized in that it comprises a suspension, in a fluid dispersant medium, of lipid microparticles containing at least one pharmaceutically active principle.
In the fluid ophthalmic compositions according to the present invention, the lipid microparticles preferably consist of a lipid phase capable of melting at the temperature of the conjunctival cul-de-sac between 30� and 40� C., in order to release the active principle.
Nevertheless, it is possible to contrive microparticles which do not actually melt but which can be removed by simple disintegration, as well as pasty particles which can line the conjunctival cul-de-sac.
By way of example, the microparticles may be prepared from a lipid base or from a mixture of fatty acids melting at 32�-38� C. The bases usable for the preparation of suppositories are, for example, very suitable.
Thus, preliminary trials were performed with semi-synthetic glycerides, in particular the base Suppocire (marketed by the company Gatefosse).
The fluid dispersant medium preferably consists of an aqueous solution of hydrophilic polymer, for example of polyvinyl alcohols, hydroxylated celluloses, polyvinylpyrrolidone or poloxamers, as well as of derivatives of these compounds or alternatively of polysaccharides or natural or synthetic polysaccharide derivatives, for example phase-transition polymers.
It has, in effect, been demonstrated that polysaccharide solutions obtained by fermentation of a microorganism, which are aqueous polysaccharide solutions of a type undergoing phase transition through the effect of an increase in ionic strength, are especially suitable according to the invention.
Thus, according to the invention, an extracellular anionic heteropolysaccharide produced by the bacterium Pseudomonas elodea, known under the name gellan gum, is preferably used. The compound known by the brand name Gelrite, which is a grade of clarified and only slightly acetylated gellan gum (marketed by the company Kelco), is preferably used.
By choosing the surface tensions of the components of the composition, it will be sought to obtain products which can be dispensed dropwise, in particular with the usual droppers.
Moreover, these fluid ophthalmic compositions can be modified so as to postpone the release of the active principle by increasing, for example, the melting point of the lipid phase.
It is also possible to produce a stepwise-release ophthalmic composition with an active principle present in the fluid dispersant medium, which principle will be immediately available, and an identical or different active principle in the lipid phase, which will be available only after a latent period or for a longer period.
The value of this ophthalmic composition hence lies in the fact of combining some of the properties of ophthalmic ointments and the possibility of solubilizing water-insoluble active principles with the ease of administration of liquid formulae.
In the compositions according to the invention, it is possible to use a wide diversity of active principles. The latter may be chosen, in particular, from the following pharmaceutical compounds:
antibacterial substances such as beta-lactam antibiotics, for example cefoxitin, n-formamidoylthienamycin and other thienamycin derivatives, tetracyclines, chloramphenicol, neomycin, carbenicillin, colistin, penicillin G, polymyxin B, vancomycin, cefazolin, cefaloridine, chibrorifamycin, gramicidin, bacitracin and sulphonamides; aminoglycoside antibiotics such as gentamicin, kanamycin, amikacin, sisomicin and tobramycin; nalidixic acid and its analogues such as norfloxacin and the antimicrobial combination of fluoroalanine/pentizidone, nitrofurazones and their analogues;
antihistaminics and decongestants such as pyrilamine, chlorpheniramine, tetrahydrazoline, antazoline and their analogues;
anti-inflammatories such as cortisone hydrocortisone, hydrocortisone acetate, betamethasone, dexamethasone, dexamethasone sodium phosphate, prednisone, methylprednisolone sodium phosphate, triamcinolone, indomethacin, sulindac, its salts and corresponding sulphides, and their analogues;
miotics and anticholinergics such as echothiopate, pilocarpine, physostigmine salicylate, diisopropyl fluorophosphate, epinephrine, dipivalylepinephrine, neostigmine, echothiopate iodide, demecarium bromide, carbamoylcholine chloride, methacholine, bethanechol and their analogues;
mydriatics such as stropine, homatropine, scopolamine, hydroxyamphetamine, ephedrine, cocaine, tropicamide, phenylephrine, cyclopentolate, oxyphenonium, eucatropine and their analogues.
Other drugs used in the treatment of eye conditions and lesions, such as:
antiglaucoma drugs, for example timolol and R-timolol and a combination of timolol or R-timolol with pilocarpine, and also many other adrenergic agonists and/or antagonists; epinephrines and a complex of epinephrine or prodrugs, and dipivefrin derivatives and hyperosmotic agents such as glycerol, mannitol and urea;
antiparasitic compounds and/or antiprotozoal compounds such as ivermectin; pyrimethamine, trisulphapyrimidine, clindamycin and corticosteroid preparations;
compounds having antiviral activity such as acyclovir, 5-iodo-2'-deoxyuridine (IDU), adenosine arabinoside (Ara-A), trifluorothymidine, and interferon and interferon-inducing agents such as polyI.polyC, carbonic anhydrase inhibitors such as acetazolamide, dichlorphenamide, 2-(P-hydroxyphenyl)thio-5-thiophenesulphonamide, 6-hydroxy-2-benzothiazolesulphonamide, 6-pivaloyloxy-2-benzothiazolesulphonamide, MK 927 and MK 417;
antifungal agents such as amphotericin B, nystatin, flucytosine, natamycin and miconazole;
anaesthetic agents such as etidocaine, cocaine, benoxinate, dibucaine hydrochloride, dyclonine hydrochloride, naepaine, phenacaine hydrochloride, piperocaine, proparacaine hydrochloride, tetracaine hydrochloride, hexylcaine, bupivacaine, lidocaine, mepivacaine and prilocaine;
Ophthalmic diagnostic agents such as:
a) those which are used for examining the retina, such as fluorescein sodium;
b) those which are used for examining the conjunctiva, cornea and lachrymal apparatus, such as fluroescein and rose bengal; and
c) those which are used for examining abnormal responses of the pupil, such as methacholine, cocaine, adrenaline, atropine, hydroxyamphetamine and pilocarpine;
Ophthalmic agents used as surgical aids, such as alphachymotrypsin and hyaluronidase;
Chelating agents such as ethylenediaminetetraacetic acid (ETDA) and deferoxamine;
Immunosuppressants and antimetabolites such as methotrexate, cyclophosphamide, 6-mercaptopurine and azathioprine; and antibiotic/anti-inflammatory combinations such as the combination neomycin sulphate/dexamethasone sodium phosphate, and combinations concomitantly treating glaucoma, for example a timolol maleate/aceclidine combination.
The ophthahic composition according to the invention must naturally fulfil the criteria for use in this field, in particular it should preferably be isotonic and have a pH lying between 5.0 and 8.0. Thus, it may incorporate other components such as tonicity regulators, preservatives and buffer systems.
The present invention also relates to a process for preparing this ophthahic composition, characterized in that:
the active principle is dissolved in the lipid base at the melting point of the latter;
the fluid dispersant medium and, optionally, the other components are dissolved in water at a temperature close to the above melting point,
the aqueous mixture obtained is added with vigorous stirring to the lipid phase,
this new mixture is cooled abruptly so as to cause solidification of the lipid droplets to microparticles.
The example below will enable other features and advantages of the present invention to be demonstrated.
A fluid ophthahic composition of the following formulation is produced according to the process described above:
______________________________________Timolol base 0.25 gSuppocie AP 4.00 gMannitol 4.50 gTromethamine 0.091 gHydrochloric acid, N qs pH 8.0-85Gelrite (L-679, 139000K) 0.60 gBenzalkonium chloride 0.01 g______________________________________
Mannitol is used as a tonicity regulator, benzalkonium chloride is used as a preservative and the combination tromethamine/hydrochloric acid constitutes the buffer system which is effective at the pH in question.
The timolol is dissolved in Suppocire melted beforehand at 40� C. The mannitol, tromethamine, N hydrochloric acid and Gelrite are, for their part, dissolved in water, heated to 40� C. and added with vigorous stirring to the lipid phase. The mixture thereby obtained is then cooled abruptly in order to obtain solidification of the lipid droplets.
A variant of this process may be carried out by performing, in the first place, in the presence of surfactants, emulsification in an aqueous phase of the organic phase comprising the organic solvent, the active principle and the lipid excipient.
Evaporation of the organic solvent is then carried out under vacuum.
The ophthalmic composition thus prepared was compared with a reference ophthalmic composition simply comprising timolol in Gelrite. The results obtained are presented in Tables 1, 2 and 3 below. The intraocular levels obtained after instillation of the ophthalmic composition according to the invention demonstrated a greater activity of the latter.
TABLE 1__________________________________________________________________________CONCENTRATIONS IN THE AQUEOUS HUMOUR AFTER INSTILLATION OFPREPARATIONS CONTAINING 0.25% OF TIMOLOL IN ALBINO RABBITSTime subsequent μg of TIMOLOL/mlto administration 10 min 0.5 h 1 h 2 h 4 h__________________________________________________________________________Composition according to 4.15 � 1.56 7.46 � 2.96 4.43 � 0.88 1.95 � 0.50 0.24 � 0.08the invention(microparticles in GELRITE)Control composition 0.98 � 0.34 3.17 � 1.29 3.67 � 1.26 1.72 � 0.91 0.24 � 0.04(GELRITE)__________________________________________________________________________ These results correspond to the mean for 12 eyes � standard deviation.
TABLE 2__________________________________________________________________________CONCENTRATIONS IN THE CORNEA AFTER INSTILLATION OF PREPARATIONSCONTAINING 0.25% OF TIMOLOL IN ALBINO RABBITSTime subsequent μg of TIMOLOL/mlto administration 10 min 0.5 h 1 h 2 h 4 h__________________________________________________________________________Composition according to 89.86 � 26.44 60.56 � 18.35 36.51 � 8.17 19.73 � 5.02 5.68 � 2.09the invention(microparticles in GELRITE)Control composition 44.1 � 8.6 46.1 � 17.1 35.7 � 11.0 16.3 � 10.3 3.3 � 1.0(GELRITE)__________________________________________________________________________ These results correspond to the mean for 12 eyes � standard deviation.
TABLE 3__________________________________________________________________________CONCENTRATIONS IN THE IRIS + CILIARY BODY AFTER INSTILLATIONOF PREPARATIONS CONTAINING 0.25% OF TIMOLOL IN ALBINO RABBITSTime subsequent μg of TIMOLOL/mlto administration 10 min 0.5 h 1 h 2 h 4 h__________________________________________________________________________Composition according to 6.90 + 1.89 8.95 + 2.59 4.57 + 0.95 4.08 + 1.67 1.27 + 1.00the invention(microparticles in GELRITE)Control composition 5.16 � 2.93 6.21 � 3.05 5.22 � 2.12 2.48 � 0.94 1.64 � 0.96(GELRITE)__________________________________________________________________________ These results correspond to the mean for 12 eyes � standard deviation.
|Cited Patent
|Filing date
|Publication date
|Oct 2, 1986
|Mar 4, 1992
|Pharmaceutical composition of the type which undergoes liquid-gel phase transition
|Remington s Pharmaceutical Sciences, Fifteenth Edition 1975, pp. 716 and 1249 1252.
|Remington's Pharmaceutical Sciences, Fifteenth Edition 1975, pp. 716 and 1249-1252.
|Citing Patent
|Filing date
|Publication date
|Nov 22, 1995
|Feb 2, 1999
|Advanced Corneal Systems, Inc.
|Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
|Aug 24, 1998
|Mar 21, 2000
|Advanced Corneal Systems
|Method for accelerating clearance of hemorrhagic blood from the vitreous body with hyaluronidase
|Apr 2, 1998
|Mar 21, 2000
|Point Biomedical Corporation
|Intravesical drug delivery system
|Mar 14, 2000
|Mar 27, 2001
|Thomas B. Ottoboni
|Intravesical drug delivery
|Mar 27, 2001
|Feb 25, 2003
|Point Biomedical Corporation
|Intravesical drug delivery system
|Dec 2, 1999
|Apr 22, 2003
|Ista Pharmaceuticals, Inc.
|Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vireous body of the eye
|Nov 19, 1999
|Aug 26, 2003
|Ista Pharmaceuticals, Inc.
|Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
|Feb 21, 2003
|Mar 8, 2005
|Advanced Corneal Systems
|Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
|Feb 14, 2003
|Sep 6, 2005
|Ista Pharmaceuticals, Inc.
|Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
|May 7, 2013
|Lux Biosciences, Inc.
|Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
|Aug 19, 2011
|Sep 17, 2013
|Lux Biosciences, Inc.
|Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
|May 5, 2010
|Apr 28, 2015
|Aurinia Pharmaceuticals Inc.
|Topical drug delivery systems for ophthalmic use
|Feb 14, 2003
|Jul 10, 2003
|Karageozian Hampar L.
|Hyaluronidase preparation for ophtalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
|Nov 12, 2004
|Mar 31, 2005
|Hampar Karageozian
|Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
|Aug 15, 2005
|Feb 16, 2006
|Karageozian Hampar L
|Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye
|Oct 8, 2008
|Apr 9, 2009
|Lux Biosciences, Inc.
|OPHTHALMIC COMPOSITIONS COMPRISING CALCINEURIN INHIBITORS OR mTOR INHIBITORS
|Oct 31, 2003
|Mar 24, 2010
|Pharmaceutical compositions suitable for the treatment of ophthalmic diseases
|U.S. Classification
|514/235.8, 514/54, 514/912
|International Classification
|Cooperative Classification
|European Classification
|Apr 8, 1994
Owner name: MERCK SHARP & DOHME-CHIBRET, FRANCE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROZIER, ANNOUK;REEL/FRAME:006933/0693
Effective date: 19901004
|Sep 2, 1997
Owner name: LABORATOIRES MERCK SHARP & DOHME CHIBRET, SNC, FRA
Free format text: CHANGE OF NAME;ASSIGNOR:LABORATOIRES MERCK SHARP & DOHME CHIBRET SA;REEL/FRAME:008695/0020
Effective date: 19961003
Owner name: LABORATORIES MERCK SHARP & DOHME CHIBRET, SNC, FRA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LABORATORIES MERCK SHARP & DOHME CHIBRET SA;REEL/FRAME:008680/0651
Effective date: 19961003
|Dec 16, 1997
|Fee payment
Year of fee payment: 4
|Dec 20, 2001
|Fee payment
Year of fee payment: 8
|Jan 18, 2006
|Maintenance fee reminder mailed
|Jul 5, 2006
|Lapse for failure to pay maintenance fees
|Aug 29, 2006
|Expired due to failure to pay maintenance fee
Effective date: 20060705


text:
Results 121 to 130 of 130
July 2nd, 2007 #121
Nice gestures and studies! Keep working on head proportions, one thing that helps when you're doing portraits is to look at the shadows shapes and simplify values down - the key to getting the likeness is all in the shadow shapes. Also, when you do your oils, *do not* start on a plain white canvas. Tone it a nice neutral color (burnt umber with a little black in it is good, you can experiment with different tones - just slop a little paint on with some turps, spread it all messy style so it covers the canvas, and give it a day or two to dry - I tone a few boards and canvases all at once so they're just ready to paint on). That way you can go both lighter and darker than the color of your canvas. Starting on white will make everything look darker than it really is when you're putting the paint on, resulting in washed-out looking paintings. The most important thing when painting is value - then temperature - trying to get the right color is dead last, just keep everything relative and it won't have to be exactly the color you see to be convincing.
And yeah, bigger brushes! Hog bristle! They force you to be more quick and confident.
Hide this ad by registering as a memberSeptember 22nd, 2007 #122
Thanks for the awesome advice nonie!
some stuff from figure class
oh and I'm lovin Ringling by the way
October 28th, 2007 #123
November 12th, 2007 #124Registered User
- Join Date
- Nov 2007
- Location
- Florida
- Posts
- 2
- Thanks
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- Thanked 3 Times in 1 Post
I think you are in my figure class...
November 16th, 2007 #125
haha ok, whats your name?
January 19th, 2008 #126
w.i.p drawing with my brand spankin new intuos tablet.
March 8th, 2008 #127
hey, i like your sketch book, i am a want to be animator to so i guess we are similar in that aspect even though am probably going to study design and do animation on my own time. Anyway i think you should try to do some more extensive life drawings ( what i mean is that you should do more life drawings with more detail more shading and ect it helps a lot) anyway thats just me but if you could check my sketchbook it would be great_________________________________________
Want to help a "artist" in need, visit my sketchbook
My Sketchbook
March 30th, 2008 #128
trying to keep this thing alive
September 13th, 2008 #129
Nice updates. This one looks great: http://img233.imageshack.us/img233/2...aitbodyex5.jpg The face is rendered nicely and in a way that keeps the focus on the face which has the most detail. That's awesome that you got a wacom tablet, stay away from filters and excessive soft brushes and you should be alright. Anyway, just wanted to say thanks for stoppin by my sketchbook. Cheers'"I must not fear. Fear is the mind-killer. Fear is the little-death that brings total obliteration. I will face my fear. I will permit it to pass over me and through me. And when it has gone past I will turn the inner eye to see its path. Where the fear has gone there will be nothing. Only I will remain."
--- Frank Herbert, Dune - Bene Gesserit Litany Against Fear
Check out my Sketchbook! Critique and Criticism welcomed.
or my Artstation
Or my stream on Twitch! http://www.twitch.tv/wwsketch
November 22nd, 2009 #130
hmm can't believe I haven't responded yet ArtZealot...well thanks for the comments and tips!
Here's a painting I did for one of my classes. One of my first Digi paintings in while...makes me sad I can't find the time to do more.
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