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Pharmacists at Jena University develop three new drug candidates against inflammation
It is something like the police force of our body: the immune system. It disables intruding pathogens, it dismantles injured tissue and boosts wound healing. In this form of 'self-defense' inflammatory reactions play a decisive role.
But sometimes the body's defense mechanism gets out of control and cells or tissues are affected: "Then excessive reactions can occur and illnesses along with them," Prof. Dr. Oliver Werz of the Friedrich Schiller University Jena says. He gives asthma, rheumatism, arteriosclerosis and cancer as examples: "For many of these diseases there are only few effective therapies without severe side effects."
But the team of researchers working together with the Jena pharmacist has now developed three active agents which may be able to improve the healing of inflammatory illnesses better in future. The scientists present the potential therapeutic agents in renowned scientific journals. The agents are able to suppress a key enzyme in the body's own cascade of inflammation.
"The enzyme called 5-LOX plays a pivotal role in the synthesis of so-called leukotrienes, which are part of numerous immunological and inflammatory processes," Prof. Werz explains. Hence, the effort to prevent the synthesis of leukotrienes has been the focus of international research for inflammatory therapy for a long time. "Thousands of publications on the subject have emerged in the last 30 years," says Werz. But apart from one exception none of these efforts have made it to the stage of an approved medication. Either the efficacy of the substances was poor or they were accompanied by unwanted side effects.
As a reason behind this, the Jena pharmacist sees the insufficient understanding of cellular regulation of the leukotriene biosynthesis and the lack of knowledge of the molecular mechanisms of agent and target molecule. "Instead of testing a number of substances to see if one of them might show any activity, we took a close look at 5-LOX and tried to find where exactly this enzyme is vulnerable and what the agents, which can interact with our target molecule, should look like," Werz describes the basis-orientated approach.
In this way the scientists of the Jena University together with partners from Austria, Italy, Turkey and Greece, were able to identify three possible agents. So for instance, a so-called benzoquinone proved to be an effective inhibitor of the 5-LOX. This is a substance which is derived from the natural product embelin from the "False Black Pepper"-plant (Embelia ribes). The pharmacists were able to show that this substance fits exactly into the active center of the enzyme and thus blocks its function. "This specifically only happens with 5-LOX," Werz says and stresses that benzoquinone may practically show no side effects.
A related substance of the red-violet natural dye indirubin, called 6-BIO, proved to be similarly promising. For this substance, the Jena researchers were able to clarify the mechanism of action as well: the 6-BIO inhibits the enzyme 5-LOX by blocking receptor sites for other molecules which are necessary for it to work properly. "In addition, 6-BIO also intervenes with the synthesis of additional inflammatory factors – the cytokines implying additional synergistic effects." This is why 6-BIO could for instance be of interest for the therapy of Alzheimer's disease, in which cytokines are also playing a role.
The third possible active agent from the Jena University's laboratory does not inhibit the 5-LOX itself, but it deactivates a helper-protein, which the enzyme needs for its effectiveness within the cell. The researchers identified this active agent, a benzimidazole with the short term BRP-7, by a virtual screening in a library consisting of nearly three million substances. "From our point of view all three of the drug candidates are very well suited to a further development as medications," Prof. Werz summarizes. However, for this, the support of the pharmceutical industry is needed.
Original Publications:
Schaible AM et al. Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase. British Journal of Pharmacology 2014 (DOI:10.1111/bph.12592)
Pergola C et al. Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase. Journal of Medical Chemistry 2014 (DOI:10.1021/jm401740w)
Pergola C et al. The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). British Journal of Pharmacology 2014 (DOI:10.1111/bph.12625)
Prof. Dr. Oliver Werz
Institute of Pharmacy
Friedrich Schiller University Jena
Philosophenweg 14, 07743 Jena
Phone: ++49 3641 / 949801
Email: oliver.werz[at]uni-jena.de
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Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt's and Peter Zoller's research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.
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JOE Riley says Oxford United should embrace being dark horses in Sky Bet League Two after Michael Appleton's side were not rated among the favourites for promotion.
Bury, Luton Town and Portsmouth lead the way in the betting markets on the eve of the new season.
United yesterday had a best price of 6-1 to claim promotion this season, ranking them around the middle of the pack.
But Riley, who joined on loan from Bolton Wanderers last month, is aiming to prove the pundits wrong.
He said: "We all hope so, don't we?
"It's not a bad thing to consider ourselves as dark horses and I think everyone in the camp is vying for the play-offs or better and I'm sure the fans are as well, so we all just want to pull in the same direction and do that."
A long-term knee injury means if Riley plays tomorrow, it will be his first competitive action since January 2013.
The right back thinks he is still several weeks from reaching top gear, but is excited to get going.
He said: "Hopefully, I can reach good fitness levels in the next couple of months and you will see the best of me."
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- Simon Eastwood agrees one-year deal to join Oxford United

subset: commoncrawl


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West Country Travel
A look at what's happening on the roads, trains, and planes.
A look at what's happening on the roads, trains, and planes.
There's disruption on First Great Western services between London Paddington and Cardiff Central and between London Paddington and Bristol Temple Meads because of flooding between Swindon and Bristol Parkway.
Delays of up to an hour can be expected and some trains may be diverted, not calling at Bristol Parkway. Diverted trains will call at Patchway with a shuttle bus to Bristol Parkway.
The disruption will last all day.
A fossil expert from the University of Bristol is part of a team that has discovered tiny bird wings encased in amber in Myanmar.
Prepare to get wet - the next band of rain is on its way!
Get your umbrellas at the ready the weather's looking generally unsettled with showers predicted.


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WNBA playoffs
WNBA playoffs
Sparks vs. Minnesota
Lynx lead, 1-0
G1: Minnesota, 94-77
Sun.: at Sparks, 12:30 p.m.
*Wed.: at Minn., 5 p.m.
Connecticut vs. Indiana
Today: at Conn., 5 p.m.
Mon.: at Indiana, 5 p.m.
*Oct. 11: at Conn.,
5:30 p.m.
*If necessary
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|By PR Newswire
Article Rating:
|March 28, 2014 08:01 AM EDT
HUNTINGTON, N.Y., March 28, 2014 /PRNewswire/ -- Radgile Design has officially launched its new website at vic2020.com to announce and promote its flagship product - the Radgile Vic 2020 Video Integration Console. The innovative console enables computer users, gamers and people who conduct business from home to enjoy a versatile workstation - complete with their large screen monitor, computing device or game console, projector, keyboard, mouse and power supply - to be used with their optimal seating choice.
The Vic 2020 eliminates the need for a desk while achieving something laptops cannot - an optimal large screen user experience for better productivity and entertainment, elimination of issues regarding placement of a mouse or stylus pad, ability to elect to share your screen via projector and the flexibility to configure and customize the console as desired. For metropolitan home-based businesses that are tight on space, the ability to simply unplug and roll the Vic2020 away without disconnecting the computer set up is noteworthy.
The website at vic2020.com will be the core hub for the company's planned outreach campaign and subsequent crowdfunding project. The website currently contains detailed images, videos, and full descriptions of the company's flagship product, the Radgile Vic 2020. In addition, the website contains convenient share buttons and links to follow the company on Facebook or Twitter, via its e-mail newsletter or RSS newsfeeds. By following the company's planned activities early, each visitor to the Web site can register as a "Radgile Super Friend" and receive direct notification about limited early bird offers.
According to the company founder, Bill Catlan, "The Vic 2020 video integration console is designed to facilitate a better way to work and play. By re-imagining how we might use our favorite computing, gaming, and entertainment devices better, the Radgile Vic 2020 allows more comfortable and more productive use of our large screen monitors and video projectors. The Vic 2020 is easy to setup and can be the perfect addition to enhance many different rooms in the home, a college dorm, or an office setting."
For more information on the Radgile Vic 2020, please visit the product's website at vic2020.com. Radgile Design is an innovative design company focused on bringing its revolutionary Radgile Vic 2020 video integration console to market. Its current activities include finalizing the Vic 2020's design for manufacturing, executing its outreach campaign, and executing its crowdfunding project.
SOURCE Radgile Design
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In addition to all the benefits, IoT is also bringing new kind of customer experience challenges - cars that unlock themselves, thermostats turning houses into saunas and baby video monitors broadcasting over the internet. This list can only increase because while IoT services should be intuitive and simple to use, the delivery ecosystem is a myriad of potential problems as IoT explodes complexity. So finding a performance issue is like finding the proverbial needle in the haystack.
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Digital Initiatives create new ways of conducting business, which drive the need for increasingly advanced security and regulatory compliance challenges with exponentially more damaging consequences. In the BMC and Forbes Insights Survey in 2016, 97% of executives said they expect a rise in data breach attempts in the next 12 months. Sixty percent said operations and security teams have only a general understanding of each other's requirements, resulting in a "SecOps gap" leaving organizations u...
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SYS-CON Events has announced today that Roger Strukhoff has been named conference chair of Cloud Expo and @ThingsExpo 2016 Silicon Valley. The 19th Cloud Expo and 6th @ThingsExpo will take place on November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. "The Internet of Things brings trillions of dollars of opportunity to developers and enterprise IT, no matter how you measure it," stated Roger Strukhoff. "More importantly, it leverages the power of devices and the Interne...
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The Chickasaw City School System is participating in the Summer Food Service Program. Meals will be provided to all children without charge. Acceptance and participation requirements for the program and all activities are the same for all regardless of race, color, national origin, sex, age or disability, and there will be no discrimination in the course of the meal service. Meals will be provided at Chickasaw High School, 50 Chieftain Way, Chickasaw, AL 36611 from June 6, 2016 to July 28, 2016. Serving times are from 11:00 am – 1:00pm Monday through Thursday, daily. ********************************************************** Regular Board Meeting July 14th, 20165:30 PM Pre-Meeting/6:00 PM Board Meeting
City of Chickasaw Board of Education201 North Craft Hwy.Chickasaw, AL 36611
Copyright © 2016 Chickasaw City Schools


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1995 Geo Tracker Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 1995 Geo Tracker
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1995 Geo Tracker ProblemsEngine Oil Leak From Front Crankshaft Seal
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I've changed wheel berings twice now in the last month followed the Chilton book to tee every time still burning up on right side any ideas
It rusted to pieces along with the bar in front of the tank plus so r the shock towers what do i do to fix all this?


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Seattle-Based DNA Response Expands Business With New Clients F...Comments June 28, 2016 - SEATTLE, WA DNA Response, a full-service agency that markets and manages brands on online marketplaces, has acquired nine new clients and is managing their brand presence on sites like Amazon, eBay, Rakuten, Sears and ... AndhraNews.net, 49 minutes ago
954 images for commerce and industry
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3rd National Standards Conclave
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Tsukiji fish market
Credit: Cityism
Creative #: 150131586
License type: Royalty-freeRoyalty-free pricing is based solely on the size of the product you need, not the specific use. You don't have to pay any additional royalties on a use-by-use basis. Once you license a royalty-free product, you may use it multiple times for multiple projects without paying additional fees. (Pornographic, defamatory, libelous or otherwise unlawful use of any image is, of course, prohibited.)
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Tsukiji Fish Market Stock PhotoAuto Post Production Filter,Color Image,Fish,Fish Market,Food and Drink,Freshness,Ice,In A Row,Indoors,Japan,Large Group of Objects,No People,Photography,Raw Food,Retail,Seafood,Square,Taken on Mobile Device,Tokyo - Japan,Transfer Image,Tray,Tsukiji Fish MarketPhotographer CityismCollection: Moment Open © Rik Moran 2012Fresh fish in ice tray at Tsukiji fish market, Tokyo.


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Salmon and noodles.
Credit: Robin MacDougall
Creative #: 98902436
License type: Royalty-freeRoyalty-free pricing is based solely on the size of the product you need, not the specific use. You don't have to pay any additional royalties on a use-by-use basis. Once you license a royalty-free product, you may use it multiple times for multiple projects without paying additional fees. (Pornographic, defamatory, libelous or otherwise unlawful use of any image is, of course, prohibited.)
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Oklahoma coach Bob Stoops dishes on the culture of college football, how Bill O'Brien and Penn State will deal with the NCAA's sanctions, the Big 12's future and more.
Predicting the 2016 season: Week 1
7hBrandon Chatmon
Most indispensable player: Oklahoma Sooners
3dBrandon Chatmon
Big 12 stats and trends: Offensive red-zone efficiency
5dBrandon Chatmon
Take Two: Big 12 game of the year?
6dJake Trotter and Max Olson
Big 12 mailbag: Burgers, baseball, bars
10dJake Trotter
Schedule analysis: Oklahoma Sooners
10dBrandon Chatmon
Odell Beckham Jr. has high hopes for Sterling Shepard
11dBrandon Chatmon
Baylor quarterbacks, Mason Rudolph excel against the blitz
12dBrandon Chatmon
Strong and weak: Oklahoma Sooners
13dJake Trotter
Why FPI is so high on the Sooners this fall
13dSharon Katz


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Associated Press
As I walk every day, I am surrounded by people — bombarded by them. I am in a mass of constant motion and purpose.
We all have the same purpose: to get to class. Occasionally I see some acquaintances of mine and I lift a hand in greeting or call out, "Hello!" But most of the time I walk silently.
As I walk, I try to take in my surroundings. But what bothers me is when I look at people and suddenly our eyes meet, they look down. Why? I am just looking at you. I am not judging you, I am not criticizing you. So why don't you look at me? I want to engage for a moment in meeting another great human being, but you ruin that moment and my gesture of friendship by looking down.
Everyone does it, not just college students — but why are we afraid to look? In a country where individuals boldly stand up and say who they're voting for, why are we afraid of looking at each other? Are we worried people will not accept the real us if our facade is down? Why won't you look at me?
Miquelle Leslie
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|By Marketwired .
Article Rating:
|February 12, 2013 02:36 PM EST
MOUNT LAUREL, NJ -- (Marketwire) -- 02/12/13 -- TelVue® Corporation (PINKSHEETS: TEVE), the innovation leader in television and Internet broadcasting for media companies, cable operators, communities and government, has expanded its cloud-hosted video broadcast solutions for the popular VIZ Media® Neon Alley app, which launched today on the Xbox 360® video game and entertainment system from Microsoft.
VIZ Media® is the largest publisher, distributor and licensor of manga and anime in North America, and Neon Alley is its featured 24/7 Internet channel. VIZ Media's Neon Alley platform offers fans a dynamic mix of action, adventure, sci-fi, supernatural, fantasy, and horror anime, uncut and dubbed into English, and presented in HD (when available) for a low monthly subscription rate of only $6.99. Neon Alley currently features weekly exclusive episodes of "Blue Exorcist," "Inuyasha: The Final Act," "Nura: Rise of the Yokai Clan," and "Tiger & Bunny." Fans can also catch other favorite blockbuster anime series from the beginning, including "Death Note," "Naruto Shippuden," "One Piece," "Vampire Knight" and more. For more information please visit NeonAlley.com.
"Ever since the Neon Alley premiere in October 2012, Xbox fans have been excited for the experience to become available on their gaming network," said VIZ Media Vice President of Animation Brian Ige. "TelVue is now powering Neon Alley on Xbox LIVE®, putting our channel in front of gaming audiences around the world."
The Neon Alley app originates from the TelVue CloudCast service, which delivers live, linear and video-on-demand programming to many devices, including over-the-top boxes, computers, smartphones, tablets, and gaming consoles.
"We are pleased that VIZ Media selected TelVue to power Neon Alley on another gaming console platform," says Paul Andrews, TelVue's SVP for Sales and Marketing. "TelVue CloudCast Internet broadcasting is constantly expanding its technological reach, and we continue to demonstrate the ability to quickly launch broadcast channels on multiple platforms with reliability and great value."
Neon Alley is leveraging TelVue's 100 percent Hosted Broadcast solutions, which can deliver secure, adaptive bit rate, multi-format, multi-resolution virtual video broadcasting services completely from the cloud without investment in hardware to the most popular connected video devices on the Internet today.
About TelVue Corporation
TelVue® Corporation is a broadcast technology innovator and leader that helps video broadcasters automate their channels, expand their audiences across multiple screens, and broaden their ability to monetize their content. TelVue's professional quality broadcast equipment and cloud video services include all-in-one digital broadcast servers, ad servers, live and VOD Internet streaming, multi-user contribution and transcoding, hosted broadcast, broadcast program sharing, and web-based digital signage. TelVue® serves the local origination and leased access needs for 8 of the top 10 Cable and Telco MSOs, powers over 1,500 hyperlocal and PEG channels, powers Over-The-Top and Subscription Internet channels on the most popular OTT boxes and gaming consoles, and delivers local and specialty programming to millions of college students, hundreds of hospitals, and to over 30 Million households. For more information about TelVue®, please visit http://www.TelVue.com
About VIZ Media
Headquartered in San Francisco, California, VIZ Media distributes, markets and licenses the best anime and manga titles direct from Japan. Owned by three of Japan's largest manga and animation companies, Shueisha Inc., Shogakukan Inc., and ShogakukanShueisha Productions, Co., Ltd., VIZ Media has the most extensive library of anime and manga for English speaking audiences in North America, the United Kingdom, Ireland and South Africa. With its popular digital manga anthology WEEKLY SHONEN JUMP magazine and blockbuster properties like NARUTO, BLEACH and INUYASHA, VIZ Media offers cutting-edge action, romance and family friendly properties for anime, manga, science fiction and fantasy fans of all ages. VIZ Media properties are available as graphic novels, DVDs, animated television series, feature films, downloadable and streaming video and a variety of consumer products. Learn more about VIZ Media, anime and manga at www.VIZ.com.
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PR Contact:
Paul Andrews
800-885-8886 x102
Email Contact
TelVue Corporation
16000 Horizon Way, Suite 500
Mt. Laurel, NJ 08054
A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
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Items by Readers
Tell us where we can find you paddling, walking and hunting.
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text:
Talents View in Talent Calculator
- Feline Swiftness
- Ysera's Gift
- Faerie Swarm
- Soul of the Forest
- Mighty Bash
- Dream of Cenarius
- Euphoria
Feline Swiftness
Increases your movement speed by 15%.
Ysera's Gift
Heals you for 4% of your maximum health every 5 sec. If you are at full health, a random nearby injured ally will be healed instead.
Faerie Swarm
35 yd range
Prevents the target from activating stealth or invisibility, and reduces movement speed by 50% for 15 sec. Deals 983 damage when cast from Bear Form. Usable in all shapeshift forms, but incurs a 6 sec cooldown while in Bear Form or Cat Form.
Soul of the Forest
Increases the damage bonus from Lunar and Solar Empowerment by an additional 15%.
Mighty Bash
Melee Range
50 sec cooldown Instant
Invokes the spirit of Ursoc to stun the target for 5 sec. Usable in all shapeshift forms.
Dream of Cenarius
Lunar Peak and Solar Peak also cause your Moonfire and Sunfire to heal an injured ally for 10,337.
You feel a deeper connection to the stars, reducing your Balance Energy cycle time by 50%. Additionally, your Lunar and Solar Empowerments also reduce the cast time of the affected spells by 20%.
Major Glyphs
Glyph of the Shapemender
Balance, RestorationPassiveEach time you activate a shapeshift form, you are healed for 5% of your maximum health.
This effect cannot occur more often than once every 5 sec.
Glyph of Entangling RootsPassiveReduces the cast time of your Entangling Roots by 0.5 sec.
Glyph of Moonwarding
BalancePassiveMoonkin Form no longer grants bonus armor, but instead grants 10% increased maximum health.
Minor Glyphs
Glyph of GracePassiveYou take reduced falling damage even while not in Cat Form.
Glyph of TravelPassiveYou gain an additional 60% movement speed while in the land version of Travel Form. This movement speed bonus will not be granted if Travel Form is activated while in combat.
This effect is disabled in battlegrounds and arenas and cannot be combined with other speed increases.
Glyph of the Flapping Owl
BalancePassiveTeaches you the ability Flap.
You flap your wings, slowing your falling speed.
- Feline Swiftness
- Ysera's Gift
- Typhoon
- Incarnation: Tree of Life
- Ursol's Vortex
- Dream of Cenarius
- Germination
Feline Swiftness
Increases your movement speed by 15%.
Ysera's Gift
Heals you for 4% of your maximum health every 5 sec. If you are at full health, a random nearby injured ally will be healed instead.
30 sec cooldown Instant
Summons a violent Typhoon that strikes targets in front of the caster within 15 yards, knocking them back and dazing them for 6 sec. Usable in all shapeshift forms.
Incarnation: Tree of Life
Talent, Shapeshift
3 min cooldown Instant
Shapeshift into the Tree of Life, increasing healing done by 15%, increasing armor by 120%, and granting immunity to Polymorph. Functionality of Rejuvenation, Wild Growth, Regrowth, and Entangling Roots is enhanced.
You may freely shapeshift in and out of this form for 30 sec, at which point the shapeshift expires.
You may freely shapeshift in and out of this form for 30 sec, at which point the shapeshift expires.
Ursol's Vortex
30 yd range
1 min cooldown Instant
Conjures a vortex of wind for 10 sec at the destination location that reduces the movement speed of all enemies within 8 yards by 50%. The first time an enemy attempts to leave the vortex, winds will pull that enemy back to its center. Usable in all shapeshift forms.
Dream of Cenarius
Increases Wrath damage by 20% and your Wrath spell causes a nearby ally to be healed for 150% of the damage done, including multistrikes.
You can apply two Rejuvenations to the same target.
Rejuvenation's duration is also increased by 3 sec.
Rejuvenation's duration is also increased by 3 sec.
Major Glyphs
Glyph of Blooming
RestorationPassiveIncreases the bloom heal of your Lifebloom when it expires by 50%, but its duration is reduced by 5 sec and your Healing Touch and Regrowth abilities no longer refresh the duration.
Glyph of Wild Growth
RestorationPassiveWild Growth can affect 1 additional target, but its cooldown is increased by 2 sec.
Glyph of Rejuvenation
RestorationPassiveWhen you have Rejuvenation active on three or more targets, the cast time of your Healing Touch spell is reduced by 10%.
Minor Glyphs
Glyph of Aquatic FormPassiveIncreases your swim speed by 50% while in Aquatic Form.
Glyph of GracePassiveYou take reduced falling damage even while not in Cat Form.
Glyph of the TreantPassiveTeaches you the ability Treant Form.
Shapeshift into Treant Form.
- Health419460
- Mana160000
- Intellect 5843
- Spell Power 8268
- Mastery 62.11%
- Crit 10.77%
- Haste 14.88%
- Multistrike 17.76%
- Versatility 1.57%
- Intellect 5843
- Spell Power 8268
- Haste 14.88%
- Spirit 783
- Crit 10.77%
- Mastery 62.11%
- Multistrike 17.76%
- Versatility 1.57%
- Strength 639
- Agility 1311
- Intellect 5843
- Stamina 6991
- Damage 1062–1388
- Attack Power 1311
- Speed 1.57
- Spell Power 8268
- Mana Regen 6428
- Armour 1340
- Dodge 3.13%
- Parry 0.00%
- Block 0.00%
- Crit 10.77%
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- Mastery 62.11%
- Spirit 783
- Bonus Armor 0
- Multistrike 17.76%
- Leech 4.47%
- Versatility 1.57%
- Avoidance 0.00%
Recent Activity
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RT @DeptofDefense: Today, after 40 years of service, we honored a very accomplished military leader, @GenMarkWelsh. Enjoy retirement! https…
#LIVE for the departure of the Official Party at the retirement ceremony of Gen....
.@GenMarkWelsh: "One last and recurring thought...#AIRPOWER, because without it, you lose." #CSAF20
#LIVE for the official Pass and Review
.@GenMarkWelsh: We serve to protect something of unimaginable value... something worth dying for. #CSAF20
.@GenMarkWelsh: To the #Airmen of the #AirForce: Thank you for making me proud everyday to stand by you & thank you for your trust. #CSAF20
#LIVE for the retirement orders, a musical tribute and remarks of Gen. Mark A. W...
.@SECAF23: Sowed among our ranks that will bear fruit for as long as the U.S. employs an #AirForce. @GenMarkWelsh #CSAF20
.@SECAF23: Team Welsh, together you have written a story of character, leadership & friendship. @GenMarkWelsh #CSAF20
.@SECAF23: @GenMarkWelsh worked hard to follow in footsteps his father laid out beginning in #WWII. #CSAF20
#LIVE for the presentation of medals and retirement orders of Gen. Mark A. Welsh...
.@SECAF23:4 decades ago @GenMarkWelsh raised his right hand & swore to support & defend our constitution. #CSAF20
#SECDEF: @GenMarkWelsh & @BettyWelsh20, the entire @DeptofDefense family wish you and your family the very best. #CSAF20
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#SECDEF: @GenMarkWelsh explained, you have to see the #AirForce Memorial from it's foundation to see full meaning #CSAF20
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RT @45thSpaceWing: We have liftoff from Cape Canaveral Air Force Station 6/24 at 10:30 am ET! https://t.co/ngjjg2TmOc
#AirForce #CSAF @GenMarkWelsh is retiring after 40 yrs of service. Watch live TODAY @1030 https://t.co/fPAxwVHMrU https://t.co/66EMp4oAMN
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Retired June 01,1983
Brigadier General David M. Hall is the deputy chief of staff, comptroller, Air Force Logistics Command, Wright-Patterson Air Force Base, Ohio.
General Hall was born in 1928, in Gary, Ind., where he graduated from Roosevelt High School in 1946. He graduated from Howard University, Washington, D.C., with a bachelor's degree in business administration in 1951. He earned a master's degree in educational sociology from the Agricultural and Technical State University of North Carolina, Greensboro, in 1966. He is a graduate of Squadron Officer School, Air Command and Staff College and Air War College, all located at Maxwell Air Force Base, Ala., and the Industrial College of the Armed Forces at Fort Lesley J. McNair, Washington, D.C. In 1976 he attended the advanced management program at Massachusetts Institute of Technology.
He enlisted in the Air Force in August 1951 and received his commission as a second lieutenant in June 1953 through the Air Force Officer Candidate School. Early in his career General Hall served in a variety of career fields which included supply, accounting and finance, data processing and as an instructor in the Air Force Reserve Officer Training Corps program.
In 1958 General Hall cross-trained into the data processing career field while stationed at Oxnard Air Force Base, Calif. He was assigned to Clark Air Base, Philippines, in July 1960 as a data processing officer. He became an assistant professor of aerospace science in the Reserve Officer Training Corps program at the Agricultural and Technical State University of North Carolina in June 1962. In August 1966 he returned to the data processing career field concurrent with his assignment to Ubon Royal Thai Air Force Base, Thailand, where he also served as comptroller of the 8th Tactical Fighter Wing.
General Hall was assigned to the Air Force Accounting and Finance Center, Denver, in September 1967. He was chief of the Computer Operations Division in the Directorate of Data Automation until 1969 when he joined a software development division as an analyst-programmer.
In March 1971 he was assigned to Scott Air Force Base, Ill., where he became chief of the Computer Operations Division for Military Airlift Command headquarters and in March 1972 he became the assistant for social actions in the Office of the Deputy Chief of Staff for Personnel at Scott. General Hall became the deputy base commander for Scott Air Force Base in May 1974 and base commander in February 1975.
General Hall was assigned to Headquarters, Air Force Logistics Command, Wright-Patterson Air Force Base, in June 1976 as the assistant deputy chief of staff, comptroller (data automation). He assumed his current duties in August 1977.
His military decorations and awards include the Legion of Merit, Meritorious Service Medal with oak leaf cluster and Air Force Commendation Medal with oak leaf cluster.
He was promoted to brigadier general Aug. 1, 1980, with date of rank July 23, 1980.
(Current as of February 1981)
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World Bulletin / News Desk
About 2,000 people occupied the centre of a Tajik border town on Thursday to demand a withdrawal of government troops, a month after a military assault aimed at capturing an ex-warlord killed dozens of people in the former Soviet republic.
The trigger for the latest protest in Khorog was the unsolved killing of another former warlord who fought the government in a 1992-97 civil war and enjoyed support among the population of the Gorno-Badakhshan autonomous region.
Protesters pitched tents on the town square. Several of the participants said by telephone that police, not troops, were watching from a distance. There was no sign of violence.
"We're here to show the authorities that you cannot kill us in our homes during the night," one of the protesters, who gave his first name as Dodikhudo, told Reuters by telephone. "As long as the troops remain in Gorno-Badakhshan, we won't be leaving."
Government forces in Tajikistan, an impoverished Central Asian nation, stormed Khorog on July 24 in pursuit of a former warlord accused of murdering the local head of the State Committee on National Security, successor to the Soviet-era KGB.
Seventeen soldiers, 30 rebels and at least one civilian were killed in the fighting, near the Afghan border about 520 km (325 miles) southeast of the capital Dushanbe.
Some analysts said the military operation, the largest of its kind in almost two years, was a show of force by President Imomali Rakhmon, whose control over parts of the country remains tenuous 15 years after the end of the civil war.
The wanted warlord, Tolib Ayombekov, denied involvement in the murder and avoided capture, but gave himself up voluntarily on Aug. 12. Though this was a condition for troops to withdraw, residents say soldiers remain stationed on the edge of the town.
Residents gathered in protest at the killing of another former warlord, Imomnazar Imomnazarov. Unknown assailants threw a grenade into his home and fired on it early on Wednesday.
The prosecutor-general's office promised to investigate the murder, but in the same statement also accused Imomnazarov of having participated in organised crime, including the smuggling of drugs and precious stones.
Separated from Afghanistan by the Pyanj river, Gorno-Badakhshan is an autonomous region where the authority of central government is fragile. Most of the regional population sided with the opposition during the 1990s civil war.
Situated high in the Pamir mountains, the region covers about half of Tajikistan but its 250,000 people account for less than 4 percent of the country's 7.5 million population. More than 30,000 people live in Khorog alone.
Several local residents, who declined to give their full names, said by telephone that many former warlords in the region earned money through crime. However, many had won the respect of local people by dividing the spoils.
"People in Gorno-Badakhshan are very poor. The commanders have always given some of their riches to their neighbours, helping them to organise weddings, funerals and studies," said one Khorog resident, who gave her first name as Midzhgona.
"People close their eyes to where the money has come from."
Political analyst Jamshed Kadyrov said authorities would risk violence should they fail to engage with local residents.
"Further silence could lead to disorder," he said. "There are many rumours around the killing of Imomnazarov. History has shown that rumours can give birth to uncontrollable violence."
Officials said the strikes began in the last week and were against extremist targets in the southern part of the country.
The poll comes as Australia attempts to rebalance its economy away from a once-in-a-generation mining boom stymied by tumbling commodities prices.
More than 840 others injured after extreme weather conditions battered eastern city of Yangcheng
Driver detained after bus carrying 56 people bursts into flames after crashing into guardrails of highway in central Hunan
Philippine army says 7 sailors abducted earlier this week handed over by kidnap-for-ransom gang to ISIL-linked militants
Blast damages several roadside vending stalls, shatters windows of nearby buildings including a school
Jailed opposition leader says parties must end internal disputes if they are to offer strong alternative to ruling alliance
North Sumatran capital of Medan teaches blind students love of Islamic holy book through braille
The Chinese government has announced it halted a communication channel with Taiwan due to the self-ruled island's refusal to recognise recognise "one China" principle with tensions rising between the two governments.
An increased amount of police has been deployed to majority Buddhist town after mob destroys mosque, religious school and Muslim cemetery
The Shangri La dialogue at the beginning of the month showed a US push towards creating a second Asian flavoured NATO
Mobs of people have burnt down a mosque and looted shops in apparent reprisal for an attack on three Zimbabweans on Tuesday, which left one man dead, while a second man died in hospital on Thursday afternoon.
Former deputy premier and ex-state chief had shared opposition stage to condemn PM and government
Says her new government 'understands we have to create an environment where our people want to return'
Sam Rainsy in self-imposed exile in US after warrant for his arrest issued stemming from years-old defamation case
US President Barack Obama said Mansour was targeted because he was an obstacle to the peace process


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St. Mary Sheriff's Needs Your Help To Find Hailey Saucier
Authorities in St. Mary Parish are asking the public for assistance in locating a missing teenager.
Authorities in St. Mary Parish are asking the public for assistance in locating a missing teenager.
Fifty-two years ago, the surgeon general issued a report linking tobacco use to cancer. More than 42% of Americans were smokers at the time. That figure is now at just over 18%, according to a report from USA Today. Louisiana's smoking rate is among the highest in the country...
We've all heard how important it is to stay hydrated this time of year, but just how much water are you supposed to drink each day?
Finding Dory has made history with the biggest opening - day for an animated movie in cinema history.
If you've ever wondered what the Cajun version of the Slap Chop would be like, allow us to introduce the 'Pie-Yow, Comme Ça!'
There is another arrest in the fraud and theft scheme involving employees of Cypress Bayou Casino. Chitimacha Tribal Chairman O'Neal Darden, Jr...
Summer Has officially arrived. Folks will be taking to the road, hitting the beach, or the pool, and going fishing. It's very important to to protect yourself from the UV rays of the sun...
$175 to 200 million worth of work will be done on Interstate 10 soon, and Acadiana residents - as well as those who pass through that area - should be very happy once it is done.
Since there's no law against doing both, I recommend buying some Doritos to snack on while you're making your DIY Doritos.
'This is the coolest announcement for me as an artist,' Clarkson said before diving into a soulful rendition of an Otis Redding classic.
A video made by folks who believe they've found either the mythical Kraken, some unknown species of sea creature, or the fictional Cthulu has gone viral.
Summer's here! That means vacations, boating, swimming and FISHING! Avid fishermen will descend on Intracoastal City this weekend for "Fishing For Memories." It's a fishing rodeo to benefit the Alzheimer's Association.


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It is a mistake to assume that content development is an assumed talent, or that it can be an afterthought in the digital marketing realm. Content strategy is more than writing for the web. There is a science and strategy behind developing quality content for web pages, blogs, advertisements and social media. And although every successful copywriter must have a foundation of basics writing skills, such as subject matter expertise, an engaging style and tone, and basic grammar usage, there is much more to being a content king.
Oct 06, 2009
Hoover's, Inc. has announced the launch of the new Hoover's Jobseeker Report, which aims to give job candidates a competitive advantage by helping them develop unique insight into targeted companies and industries as they conduct employment searches and prepare for interviews.
The reports provide interview preparation questions and an overview of business challenges and opportunities from First Research industry profiles and also include company contact information and description, top competitors, recent company news and announcements, stock performance and key financials.


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157 years of Northwestern Mutual
We trumpet Harley-Davison's anniversaries, as we should. But, Northwestern Mutual has a track record that goes back 157 years in Milwaukee. Today the company is a worldwide brand and this week it opens its annual "Meeting of the Association of Agents."
That's right 157 years in business, and 134 years of annual meetings. Indeed, Northwestern Mutual will hold its 134th Annual Meeting of the Association of Network Representatives in Milwaukee on July 19-23. The company's annual meeting will have an estimated economic impact of approximately $12.9 million for the local economy and will occupy about 13,819 hotel room nights.
"We are thrilled to welcome Northwestern Mutual back to Milwaukee once again," said Paul Upchurch, president and CEO of VISIT Milwaukee. "Northwestern Mutual represents the largest convention of our year and has a tremendous impact on our area's economy. We look forward to welcoming the thousands of attendees to Milwaukee and creating great experiences for them while they're here."
Agents and their families flock to Milwaukee every year, and each year I love the buzz that's created by adding nearly 11,000 temporary residents to Downtown Milwaukee.
As part of the annual meeting, some agent offices are raising funds for childhood cancer research and Alex's Lemonade Stand Foundation and running in a 5K.
For Northwestern Mutual, it's an opportunity for the company's employees and financial professionals to reflect on another strong year and to showcase what's coming here in Milwaukee. The company expects to distribute dividends exceeding $5 billion (the largest in its 157-year history) to participating policyowners and maintains the highest financial strength ratings awarded to any life insurer by all four of the major credit rating agencies.
Northwestern Mutual will conduct events and seminars for its financial representatives at the Wisconsin Center, the BMO Harris Bradley Center and at hotels including the Hilton Milwaukee City Center, the Hyatt Regency Milwaukee, the InterContinental Hotel & Resort and The Pfister Hotel. In addition, the company is sponsoring activities for the financial representatives' families at such venues as the Milwaukee Art Museum, Discovery World, the Gift of Wings Kite Shop, Milwaukee County Zoo, Betty Brinn Children's Museum and the Milwaukee Public Museum and Daniel M. Soref National Geographic Dome Theater.
And then there's the private big name show. Each year Northwestern Mutual brings a major entertainer in, too. Maroon Five, Kenny Chesney, Tim McGraw and others have headlined shows for the company and its families. Who will it be this year?
When you see you an agent (easy to spot with lanyard name tags) this week, say hello and be sure to welcome them to Milwaukee. You might want to say happy 134th, too!
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Recent Articles & Blogs by Jeff Sherman
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Published June 21, 2016
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Four vacant spaces in Downtown that need to be filled now
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There's growth everywhere in Downtown Milwaukee, but still opportunities and eyesores. For me, these four spaces have been vacant for too long. I see them all nearly everyday. Let's all chime in and help the owners or leasing agents find the right new tenant.
Milwaukee bars left off new Esquire "Best Bars in America" list
Published May 25, 2016
The "Best Bars in America" feature has been around since 2006. And - of course - a lot has changed on the drinking scene here and in every city in America. One change, no Milwaukee bars appear on this year's list.
Sprecher brews BoDeans Original Ginger Beer to celebrate band's anniversary
Published May 23, 2016
To help celebrate 30 years of "Love & Hope & Sex & Dreams," the T-Bone Burnett-produced debut by Milwaukee's own BoDeans, Milwaukee-based Sprecher Brewing is releasing BoDeans Original Ginger Brew.
Newly retired NBA ref legend will miss Milwaukee and Calderone Club the most
Published May 20, 2016
This warms my Milwaukee heart. Not only am I a Bucks and NBA fan, easily one of my favorite restaurants in the area in the Calderone Club. Both got some national love this week.
A few local, natural tips for you and your lawn
Published May 14, 2016
If you are tackling your lawn on your own this spring and summer, it's always good to consult an expert first. I've done just that here.
Must watch: 1995 Wisconsin Sports Hall of Fame ceremony
Published May 12, 2016
A few weeks ago, Donald Driver and Bo Ryan were inducted into the Wisconsin Athletic Hall of Fame. I recently found the 1995 induction ceremony featuring emcee Bob Costas and an amazing list of inductees including Al McGuire, Robin Yount and The Big O.
Downtown Milwaukee needs which type of restaurant next?
Published May 4, 2016
As we look at the growth in greater Downtown, I think a place like City Winery could do well. It's unique, large and creates an experience that's missing in our market. But, what do I know? What do you think?


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You missed it This great deal for Polpettina Market is over. But don't despair, we've got more great deals every day.
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Polpettina Market
$20 to Spend in Gourmet Market and Coffee Shop
There are certain elements that make up the quintessential Italian family: vibrant conversation, an over-affectionate grandmother, and of course, a secret meatball recipe. With today's deal from the gourmet market at Polpettina Homestyle Pizza Kitchen -- which The New York Times calls "otherworldly good" -- secure the necessary ingredients to come up with your own recipe. Pay $10 for $20 to spend on gourmet groceries, organic ground-to-order coffee, or freshly baked pastries and bread at this award-winning Eastchester eatery. This gorgeously decorated spot features cozy seating and floor-to-ceiling shelves, which are made from reclaimed wood and are brimming with high-quality, artisanal products. You can pick up homemade sauces, pickles, olive oil, and more; or, if you want to stay for a light bite, work your way through thoughtfully plated tapas. Whatever you opt for, you'll partake in a truly authentic experience -- minus the excessive cheek kisses from Grandma.
Want more? Check out Polpettina Homestyle Pizza Kitchen on Facebook.
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- //Home
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- //Carmen Consoli | Patti Smith
Patti Smith joined the Sicilian singer-songwriter Carmen Consoli to perform Consoli's "Mio Zio"(My Uncle) in Turin, Italy. The song, from Consoli's latest album, Elettra, is a first-person narrative of a young woman who, at her uncle's funeral, recalls the sexual abuse he inflicted on her when she was a child. Consoli's narrator remembers how her uncle called the abuse blind man's bluff and riding a carousel. Patti picks up on Carmen's imagery and riffs on it brilliantly. She knows what Italy's known for years and the rest of the world is finding out—Carmen Consoli is one of the most distinctive artists on the international scene.
Topics: carmen consoli | patti smith
//Mixed media
Machinedrum "Dos Puertas" ft. Kevin Hussein (Singles Going Steady) // Music
Alex Cameron "Take Care of Business" (Singles Going Steady) // Music
Lucky Chops "Buyo" (video) (premiere) // Music
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// Short Ends and Leader
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This paper describes a paradigm for implementing software in which 1) a database is used to maintain virtually all recorded information about the application and 2) the executable product is generated directly from the formal specifications. A specific environment, TEDIUM®, defined for a specific application class, the interactive information system, is presented as a proof of concept. The benefits of this paradigm are evaluated briefly, and the characteristics associated with its in productivity improvement are identified.
A not-for-profit organization, IEEE is the world's largest technical professional organization dedicated to advancing technology for the benefit of humanity.© Copyright 2016 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.


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Darwin Ramos 34 P
Kingsport Mets
- Rookie | Appalachian League
- MLB Parent Club: New York Mets
- Status: Active
- Full Name: Darwin Jose Ramos
- Age: 20 (November 23, 1995)
- Birthplace: Valencia, Venezuela
- Bats/Throws: R/R Ht: 6' 2" Wt: 195
Darwin Ramos Stats Summary
Darwin Ramos Career Stats
MiLB.com News
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MiLB.com Video
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|October 22, 2015
|Navegantes del Magallanes placed RHP Darwin Ramos on the reserve list.
|October 7, 2015
|RHP Darwin Ramos assigned to Navegantes del Magallanes.
|June 21, 2015
|RHP Darwin Ramos assigned to Kingsport Mets from GCL Mets.
|June 19, 2014
|RHP Darwin Ramos assigned to GCL Mets.
|June 1, 2013
|RHP Darwin Ramos assigned to DSL Mets2 from DSL Mets1.


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Review Etowah Valley Country Club & Golf Lodge - North/West Course
The Fine Print:
Golfable Golf Quote of the Day:
" Actually, the only time I ever took out a one-iron was to kill a tarantula. And it took a seven to do that. -- Jim Murray "
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