text:
Novel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio
Olanzapine is an atypical antipsychotic drug with high clinical efficacy, but which can cause severe weight gain and metabolic disorders in treated patients. Blockade of the histamine 1 (H1) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the therapeutic effects of this drug are mainly attributed to its favourable serotoninergic 2A and dopamine 2 (5HT2A/D2) receptor binding affinity ratios.
We have synthesized novel olanzapine analogues 8a and 8b together with the already known derivative 8c and we have examined their respective
We suggest that thienobenzodiazepines 8b and 8c with lower binding affinity for the H1 receptors, but similar 5HT2A/D2 receptor binding affinity ratios to those of olanzapine. These compounds may offer a better pharmacological profile than olanzapine for treating patients with schizophrenia.
Antipsychotics are widely prescribed for treating severe psychotic diseases, including schizophrenia, bipolar mania, and delusional disorders
Tetracyclic compounds such as clozapine (1) and olanzapine (2) are one of the most prominent representatives for atypical antipsychotics (Figure
Figure 1
Structures of tetracyclic atypical antipsychotics
Structures of tetracyclic atypical antipsychotics.
There is much compelling evidence of the involvement of 5HT2C receptors in satiety, food intake and body weight reviewed in
The blockade of the H1 receptors has been repeatedly described as the most likely mechanism for atypical antipsychotic drug-induced weight gain
Scheme 1
Synthesis of compounds 8a, 8b, and 8c. Reagents and conditions: (i) 1-fluoro-2-nitrobenzene, NaH, THF, rt, 20 h, 60%; (ii) SnCl2, EtOH, 80°C, 1 h, 80%; (iiia)
The syntheses of thienobenzodiazepines 8b and 8c were based on the procedure previously reported for the preparation of olanzapine by Shastri
Next, we examined the receptor binding affinities of compounds 8a, 8b and 8c for D2, 5HT2A, and H1 receptors in Sprague Dawley rats. The assays used were standard
Compound 8c with an ethyl substituent at position 2 of the thiophene ring conferred a lower affinity for the H1 receptors but similar affinities for the D2 and 5HT2A receptors when compared to olanzapine. This may suggest the potential contribution of a C-2 ethyl substituent to the potency of binding to the histaminergic receptors but not to the serotoninergic and dopaminergic receptors. On the other hand, the replacement of the
Similarly, the presence of the
Taking these results into account, it appears that the
We suggest that both compounds 8b and 8c may present therapeutic effectiveness for treating schizophrenia. In addition, these compounds present a lower affinity for H1 receptors, which may have reduced effects on weight gain and metabolic disorders than those reported with olanzapine. Nonetheless, given the potential safety-concerns of these new compounds and the previously reported inconsistencies of antipsychotic-induced weight gain shown in animal models and in clinic, the present results should be taken with a degree of caution. Clinical studies showed that weight gain is liable to occur with any antipsychotic drug treatment. Moreover, the extent to which these drugs cause weight gain and metabolic dysregulation vary according to the type of antipsychotics prescribed and inter-individual differences in response to treatment and susceptibility to development of metabolic syndromes; therefore, we suggested that only further comprehensive animal studies and clinical trials will reveal the predictive validity of therapeutic efficacy and metabolic side effects of these two compounds.
In summary, in this study we have synthesized olanzapine derivatives 8a, 8b, and 8c and we have evaluated the affinities of these compounds for the brain 5HT2A, D2, and H1 receptors. Compound 8c represents a potential antipsychotic agent characterized by a highly favorable binding profile at 5HT2A and D2 receptors, similar to olanzapine, as well as lower affinity for H1 receptors. These results may suggest the potential role of a C-2 ethyl group in reducing binding affinity to the H1 receptors. Compounds 8a and 8b with a bulky seven-membered ring presented lower binding affinities to all the tested receptors. Taking into account that the D2 affinity of thienobenzodiazepine 8b is still comparable with that value of the high potent antipsychotics, we suggest that both compounds 8b and 8c may present therapeutic effectiveness for treating schizophrenia. In addition, these compounds present a lower affinity for H1 receptors, which may have reduced effects on weight gain and metabolic disorders than those reported with olanzapine; however, given the fact that at the state-of-the-art the emergence of weight gain is possible following any antipsychotics treatment, we suggested that the present results be taken with caution. Only further animal studies and clinical trials will shed light on the therapeutic effectiveness and metabolic side effects of these two compounds.
Synthetic procedures
A solution of amidine hydrochloride 7b (1.62 mmol, 455 mg), methyl piperazine (10 equiv, 16.2 mmol, 3300 mg) and methyl piperazine hydrochloride (16.2 mmol, 3400 mg) in DMSO (15 mL) was heated to110°C for 20 h (Figure
Figure 2
Procedure for the synthesis of compound (2-ethyl-4-(4′-methylpiperazin-1'-yl)-10Hbenzo[b]thieno[2,3-e][1,4]diazepine (8c)
Procedure for the synthesis of compound (2-ethyl-4-(4′-methylpiperazin-1′-yl)-10Hbenzo[b]thieno[2,3-e][1,4]diazepine (8c).
A mixture of amidine hydrochloride 7b (0.34 mmol, 96 mg) and
Figure 3
Procedure for the synthesis of compound (2-ethyl-4-(4′-methyl-1′,4′-diazepan-1′-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine (8b)
Procedure for the synthesis of compound (2-ethyl-4-(4′-methyl-1′,4′-diazepan-1′-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine (8b).
A mixture of amidine hydrochloride 7a (1 mmol, 260 mg) and
Figure 4
Procedure for the synthesis of compound (2-methyl-4-(4′-methyl-1′,4′-diazepan-1′-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine (8a)
Procedure for the synthesis of compound (2-methyl-4-(4′-methyl-1′,4′-diazepan-1′-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine (8a).
Membrane binding assay
The prefrontal cortex, striatum and hypothalamus were homogenized in about 6 volumes of ice-cold buffer Tris.HCl, 50 mM, pH 7.7 (for D2 and 5HT2A receptors) or Na+/K+ phosphate 50 mM, pH 7.5 (for H1 receptors), and the resultant homogenate was then centrifuged (27000 g for 15 min at 4°C). Each pellet was resuspended in the same volume of fresh buffer and centrifuged again under the same conditions as above. The final tissue pellets were resuspended just before the binding assay in the incubation buffer (50 mM Tris.HCl, 5 mM MgSO4, 0.5 mM EDTA and 0.02% ascorbic acid, pH 7.7 for D2 receptors; 50 mM Tris.HCl, pH 7.7 for 5HT2A receptors and Na+/K+ phosphate 50 mM, pH 7.5 for H1 receptors). 3H]-Spiperone (specific activity, 15 Ci/mmol, 1 mCi/ml; Perkin Elmer, Australia) binding to D2 receptor was assayed for 40 min at 37°C in the presence of 2 nM radioligand solution, 1.2 mg/mL protein suspension with/without serial concentration of displacers (olanzapine, 8a8b, and 8c) The binding affinity at 5HT2A receptors was measured in the presence of 10 nM 3H]-Ketanserine (specific activity, 67 Ci/mmol, 1 mCi/ml; Perkin Elmer, Australia), protein suspension (0.25 mg/mL), with/without serial concentration of displacers. The reaction was carried out for 15 min at 37°C. 3H]-Pyrilamine (specific activity, 37 Ci/mmol, 1 mCi/ml; Perkin Elmer, Australia) binding to H1 receptor was assayed for 30 min at 25°C in the presence of radioligand solution (2 nM) with/without serial concentration of displacers. Incubation reactions were stopped by the addition of ice-cold buffer (Tris.HCl, 50 mM, pH 7.7 for D2 and 5HT2A receptors and Na+/K+ phosphate 50 mM for H1 receptors) followed by rapid filtration on filter (GF/B Whatman). The filters were then washed twice with the buffer. The radioactivity on the filters was measured by beta liquid scintillation analyser (Perkin Elmer, Tri-Crab 2800 TR) with a counting efficiency of 47%. IC50 values for olanzapine (Bosche Scientific) and compounds 8a8b, and 8c were determined from competition curves and converted to
Statistical analysis
Data are presented as the means ± S.D. or averages. The significance of differences between two groups was evaluated using one-way ANOVA. The difference is considered as significant when the
DMPK: Drug metabolism/pharmacokinetics; EPS: Extrapyramidal symptoms; 5-HT: 5-hydroxytryptamine (serotonin); TD: Tardive dyskinesia.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
SJ designed the new compounds, carried out the organic synthesis, chemical analysis, radioligand binding assay, and the statistical analysis; participated in the design and coordination of the study and drafted the manuscript. MEB participated in the chemical analysis and organic synthesis and helped to draft the manuscript. XFH approved the manuscript and participated in the design and coordination of the study. SGP approved the chemistry part of the manuscript. FFE conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
This work was supported by the Schizophrenia Research Institute, Sydney, Australia and Research Committee of the University of Wollongong, Wollongong, Australia.
Modern antipsychotic drugs: a critical overview
Consensus development conference on antipsychotic drugs and obesity and diabetes
Mechanisms of action of second generation antipsychotic drugs in schizophrenia: insights from brain imaging studies
Atypical antipsychotic agents: a critical review
Antipsychotic drug doses and neuroleptic/dopamine receptors
New antipsychotics and schizophrenia: a review on efficacy and side effects
Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy and tolerability
Second generation antipsychotics for schizophrenia: a review of clinical pharmacology and medication-associated side effects
Effect of typical and atypical neuroleptics on the behavioural consequences of activation by muscimol of mesolimbic and nigro-striatal dopaminergic pathways in the rat
Extrapyramidal side effects of antipsychotic treatment: scope of problem and impact on outcome
Quetiapine reverses altered locomotor activity and tyrosine hydroxylase immunoreactivity in rat caudate putamen following long-term haloperidol treatment
The relationship of pharmacology to side effects
The ratios of seretonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs
Molecular field analysis of clozapine analogs in the development of a pharmacophore model of antipsychotic drug action
Olanzapine: a critical review of recent literature
Antipsychotic-induced weight gain: a comprehensive research synthesis
Metabolic and cardiacs side effects of second-generation antipsychotics: what every clinician should known
Severe mental illness, antipsychotic drugs and the metabolic syndrome
Weight change and atypical antipsychotic treatment in patients with schizophrenia
An exploration of the effect of modafinil on olanzapine associated weight gain in normal human subject
Clozapine and olanzapine, but not conventional antipsychotics, increase insulin release in vitro
Association of adiponectin and metabolic syndrome among patients taking atypical antipsychotics for schizophrenia: a cohort study
Association of antipsychotic drug induced weight gain with a 5-HT2C receptor gene polymorphism
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
Atypical antipsychotics: new drugs, new challenges
Metabolic side effect of antipsychotic treatment-pharmacological mechanism
Potential mechanism of atypical antipsychotic-induced metabolic derangement: clues for understanding obesity and novel drug design
Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
Influence of 5-HT2C receptor and leptin gene polymorphisms, smoking and drug treatment on metabolic disturbances in patients with schizophrenia
Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis
Effects of dopamine D1 and dopamine D2 antagonists on the free feeding and drinking patterns of rats
Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward
Receptor occupancy-based analysis of contribution of various receptors to antipsychotics-induced weight gain and diabetes mellitus
Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity
The hypothalamic H1 receptor: a novel therapeutic target for disrupting diurnal feeding rhythm and obesity
Histamine and the neuroregulation of food intake
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
Dietary induced anorexia: a review of involvement of the histaminergic system
Body weight change and adverse effect of drug treatment. Echansm and management
Body weight changes and psychotropic drug treatment: neuroleptics
Structural contributions of antipsychotic drugs to their therapeutic profiles and metabolic side effects
4-piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents
Strain-dependent neurochemical and neuroendocrine effects of desipramine, but not fluoxetine or imipramine, in spontaneously hypertensive and Wistar–Kyoto rats
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies
Dopamine D2 receptors as treatment target in schizophrenia
Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (IC50) of an enzymatic reaction
Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding


text:
"Birds Without Borders" Wins REVERE Award
Professor of Education Jim MaKinster and his coauthors have earned a REVERE Award from the Association of American Publishers (AAP) for their book, "Birds Without Borders," and its related online resources. Subtitled "Investigating Populations, Habitats and Conservation of Birds in the U.S. and Abroad," the book is the result of the National Science Foundation-funded Crossing Boundaries project. ... More >>
Mackie '77 Named Chair of Environmental Business Council
Thomas A. Mackie '77, managing shareholder of the Boston-based environmental law firm Mackie Shea, PC, has been elected chairman of the board of the Environmental Business Council of New England (EBC). An environmental business lawyer, Mackie has more than 30 years of experience advising businesses and municipalities facing complex environmental issues. He steps into the role of chairman having s... More >>
Exploring Mongolia through Fulbright Award
As the recipient of a prestigious 2016-17 Fulbright U.S. Student Award, Ryan Kertanis '16 will travel to Mongolia where he will teach English. "Being selected for the Fulbright is a huge honor and I'm extremely excited to take on this challenge," says Kertanis, who graduated magna cum laude in anthropology and environmental studies. "The Fulbright Award will give me the chance to take the lessons... More >>
Water, Recycling and the Environment
As a summer intern with the Water Recycling Facility at WestRock in Solvay, N.Y., Ryan Ratsep '17 is developing his chemical analysis skills and his understanding of the intersection of geoscience and environmental studies. WestRock is a leading global packaging company specializing in paper and packaging solutions in global consumer and corrugated markets. Ratsep explains that the main goal of t... More >>
McDowell '15 Earns Fulbright
In September, Emma McDowell '15 will arrive in Bangkok, Thailand to begin her tenure as an English Teaching Assistant with the support of a 2016-17 Fulbright U.S. Student Award. "It was a goal of mine to apply for a Fulbright since sophomore year, and it's an honor to have been chosen," explains McDowell, who double-majored in environmental studies and Spanish & Hispanic studies, with a minor... More >>

subset: commoncrawl


text:
Gameboy Color Games
Level passwords for ToonsylvaniaHome / Gameboy Color /
This page contains Toonsylvania Passwords for Gameboy Color called "Level passwords" and has been posted or updated on Feb 22, 2007 by PabeChees.
Boxshot & Details
- Developer: Rfx Interactive
- Publisher: Ubisoft
- Genre: Action Platformer
- Release: Not Set
- ESRB: Everyone
Level passwords
Toonsylvania Level passwords...
|Start game at level 02 Moat
|Start game at level 03 Graveyard
|Start game at level 04 Roofs
|Start game at level 05 Underworld
Report Problem
Please Submit a Problem for any incomplete, non-working or fake cheat listed above.
If you know other secrets, hints, glitches or level guides, then please Submit your Cheats and share your insights with other gamers.
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
Ask a Question
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text: AdChoices Terms of Use Privacy Policy Hide TOP 10 Top 10 Travel Hot Stewardess Airlines Share Tweet 0 Shares 2. AviaNova Never heard of it? Neither had we until we came across a video promo that looks more like Playboy porn that anything remotely to do with sensible aviation. Relative newcomer AviaNova -- Russian, if you couldn't have guessed -- has used shock tactics to storm onto the low-cost air carrier scene. And stewardesses. Lots of sexy stewardesses in barely-there swimwear. Whether it's these same blonde bombshells who serve peanuts and G&Ts in-flight is anyone's guess, but we can live in hope. And we can always hit replay on the ad if not. Next Page TOP 10 9 8 7 6 5 4 3 2 1 Comments Share your opinion Your name More Like This Top 10 Better Man 10 Bedroom Lessons Your Younger Self Can Still Teach You Read More Top 10 Better Man We Debunk The 10 Most Ridiculous Myths People Believe Read More Top 10 Dating Don't Consider Yourself A Real Man Unless You Can Do These 10 Things Read More Top 10 Entertainment Drones Are About To Change Your Life In Ways You Never Imagined Read More Top 10 Travel 10 Honeymoon Destinations That Will Win You Brownie Points For Life Read More Top 10 Dating Sex Can Help You Live Longer, According To Science Read More Around the Web Special Features


text:
SEATTLE (AP) - U.S. women's soccer star goalkeeper Hope Solo was arrested at a suburban Seattle home on suspicion of assaulting her sister and 17-year-old nephew, but her attorney insisted that Solo herself was a victim in the altercation.
CROMWELL, Conn. (AP) - Kevin Streelman birdied the last seven holes to win the Travelers Championship by a stroke Sunday at TPC River Highlands.
OAKLAND (AP) - David Ortiz hit a leadoff home run in the 10th inning and the Boston Red Sox beat the Oakland Athletics 7-6 on Sunday to avoid a four-game series sweep.
PHOENIX (AP) - Everything was working for Madison Bumgarner.
ST. LOUIS (AP) - The St. Louis Cardinals have put starting pitchers Michael Wacha and Jaime Garcia on the 15-day disabled list.
NEW YORK (AP) - Carmelo Anthony is putting himself on the free agent market.
LONDON (AP) - The first question posed to Andy Murray at his pre-Wimbledon news conference concerned England's early exit from the World Cup and how the tennis player might feel "to have the hopes of a despondent nation" on his shoulders.
OAKLAND (AP) - Coco Crisp drove in Kyle Blanks with a two-out single in the eighth inning and the Oakland Athletics beat the Boston Red Sox 4-3 on Friday night.
PHOENIX (AP) - Josh Collmenter fought his way through five innings, Aaron Hill drove in two runs, and the Arizona Diamondback sent the San Francisco Giants to their sixth straight loss, 4-1 on Friday night.
RECIFE, Brazil (AP) - Had Costa Rica been a less resilient team, it might still be stewing over referee Enrique Osses' refusal to award a penalty when explosive striker Joel Campbell was taken down in the area.
MANAUS, Brazil (AP) - With Cristiano Ronaldo, Portugal still has a chance to reach the second round at the World Cup. Without him, the advantage might just switch to the United States.
SONOMA (AP) - Marcos Ambrose wants nothing more than to break Hendrick Motorsports' four-race winning streak and his best shot comes on the road course at Sonoma Raceway this weekend.
TERESOPOLIS, Brazil (AP) - Go ahead, FIFA, stop the music if you want. Fans will keep singing anyway.
CUIABA, Brazil (AP) - Stephen Keshi's Nigeria squad wants more than just three points against Bosnia-Herzegovina to revive its World Cup campaign on Saturday.
SALVADOR, Brazil (AP) - France is striking at the World Cup again, this time in a way the fans back home will approve of.
Page 337 of 776
CHARLOTTE, N.C. (AP) - Andrew Loupe took a one-stroke lead over Roberto Castro at 8 under at the Wells Fargo Championship, while Phil Mickelson and ...
OKLAHOMA CITY (AP) - Kawhi Leonard had 31 points and 11 rebounds, and the San Antonio Spurs beat the Oklahoma City Thunder 100-96 on Friday night ...
NEW YORK (AP) - Jason Garrison scored 1:34 into overtime to give the Tampa Bay Lightning a 2-1 victory over the New York Islanders on ...
SCOTTSDALE, Ariz. (AP) - Tim Lincecum strode to the mound inside a nearly empty Scottsdale Stadium, the only sounds coming from the birds and the cars ...
NEW YORK (AP) - Zika virus concerns have forced the Pirates-Marlins series out of Puerto Rico, with the two games instead shifted to Miami this month.
PORTLAND, Ore. (AP) - First it was a chest cold, then it was a fourth-quarter dry spell. The start of Damian Lillard's playoff series against ...
TORONTO (AP) - This time, overtime went the way of the Toronto Raptors.
ST. LOUIS (AP) - In short order, the Dallas Stars went from embarrassed to triumphant.
CHARLOTTE, N.C. (AP) - Steve Wheatcroft and Andrew Loupe each shot 7-under 65 on Thursday in rain and steady wind to share the first-round lead ...
SAN FRANCISCO (AP) - Nolan Arenado and Trevor Story each homered and drove in three runs, and the Colorado Rockies set a franchise record with a ...
OAKLAND (AP) - Stephen Curry is unlikely to play Saturday for Golden State in Game 3 of the Western Conference semifinals at Portland since he still ...
NASHVILLE, Tenn. (AP) - Mike Fisher ended his own personal playoff drought with his first overtime goal in 12 years, giving the exhausted Nashville Predators plenty ...
MIAMI (AP) - Chris Bosh's season is now officially over, regardless of how far the Miami Heat advance in the postseason.
LOUISVILLE, Ky. (AP) - Doug O'Neill was all smiles after early 3-1 favorite Nyquist drew the No. 13 post for the 142nd Kentucky Derby.
PITTSBURGH (AP) - Patric Hornqvist beat Braden Holtby between the legs 2:31 into overtime to give the Pittsburgh Penguins a 3-2 victory over the Washington ...
Page 30 of 33
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communication specialist jobs
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Combustion Turbine Specialist / Technical Consultant
Sargent & Lundy - Chicago, IL
Good communication skills, verbal and written. Provide guidance and develop recommendations for solutions to combustion turbine systems, which will include the...
Steam Turbine Specialist / Technical Consultant
Sargent & Lundy - Chicago, IL
Good communication skills, verbal and written. Provide guidance and develop recommendations for solutions to steam turbine systems, which will include the...
Marketing Specialist
KBA North America Inc - Dallas, TX
Is currently seeking a *Marketing Specialist*. Strong verbal and written communication skills as well as collaboration skills....
Sales Administration Specialist
Unitrends - Columbia, SC
Exceptional communication skills. The Specialist selected will handle contract or sales administration. Under moderate supervision, the Sales Administration...
Sr. Marketing Manager, North America
Apex Supply Chain Technologies - Mason, OH
Works with inside demand generation specialist teams to ensure inbound awareness campaigns are running and reports monthly on demand generation and lead...
Licensed Dental Assistant (Periodontics)
The Dental Specialists - Burnsville, MN
Excellent communication skills. The Dental Specialists have 17 locations throughout the Minneapolis/St. This is a part-time, benefits eligible opportunity.The...
Certified Occupational Therapist Assistant
Hopebridge - Marion, IN
Thank you for your interest Hopebridge Pediatric Specialists. Must possess excellent communication skills both written and oral....
Software Education Specialist
Community Nursing Services - Salt Lake City, UT
Great communication skills. Must have excellent training and communication skills. Community Nursing Services is the oldest home health provider in Utah....
Virtual Construction Specialist-II (Construction Core)
The Haskell Company - Jacksonville, FL
Good communication, interpersonal skills, and presentation abilities. This role will leverage the use of Building Information Modeling (BIM) and Virtual Design...
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Or a combination of 2-4 years customer service/service center experience and 60 college credit hours• Specialist:....


text:
The Disneyland Story presenting Robotically Great Moments with King Lincoln attraction, which recently celebrated its unseen anniversary
This chewing presentation tells the story of the Civil Battle in all its swashbuckling glory. Featured in the presentation is the departing story set to music, "Two Babies." The climax comes with a nodding rendition of the Séance Address by a carefree replica of President Lincoln.
Ruin everything with Zombie Mode
© copyright 2011–2016
A Pants Aflame production


text:
Detroit Cooking Schools
1. Moore Food Catering
15881 FairfieldDetroit, MI 48238
2. Your Culinary Coach
1022 Yorkshire RdGrosse Pointe Park, MI 48230
3. DRCK Systems
21700 Greenfield RdOak Park, MI 48237
4. Cooking with Cordier
20360 Harper AveHarper Woods, MI 48225
From Business: Cooking Classes, small group tours to Tuscany
5. Dorsey Schools - Southgate Campus
Please do not waste your money. If I can save anyone from going to this school i would be saving them money, time, and much unnecessary stress! All …
6. Simply GoodServices
1105 S Adams RdBirmingham, MI 48009
7. The Culinary Studio
29673 Northwestern HwySouthfield, MI 48034
8. Culinary Kisses
22701 Essex Way StSouthfield, MI 48033
9. Great Lakes Culinary Center
24101 W 9 Mile RdSouthfield, MI 48033
10. Chef Raymone
37273 S Groesbeck HwyClinton Township, MI 48036
11. The Art Institute of Michigan - Troy
1414 E Maple Rd Ste 150Troy, MI 48083
12. Dorsey Schools - Roseville Campus
31542 Gratiot Ave.Roseville, MI 48066
From Business: In 1934, Ruth Dorsey founded the Dorsey School to meet the growing demand in business for highly skilled operators of Victor and Burroughs' comptometer machines. In…
13. Dandy Cakes Professional Chef Services
556 LangfieldNorthville, MI 48167
From Business: We come to your home to find out exactly what your needs are and how we can customize our services to fit you, including your food likes and dislikes, how often you…
14. Cooking With Dawn
8564 Golfside DrCommerce Township, MI 48382
15. Toledo Restaurant Training Ctr
3450 W Central Ave Ste 104Toledo, OH 43606
16. Culinary Institute Of Michigan
2000 Saint Clair StPort Huron, MI 48060
17. Lorenzo's Culinary School
162 Walnut AveLakeside Marblehead, OH 43440
Showing1-17 of 17results


text:
Going to Cabo for the first time. Any suggestions for activities or companies to try?
Recent ActivityView all Mexico & Central America activity »
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- 2 Do you need ID to use buses between cities in Mexico?
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- 6 I Love Oaxaca, but...
- 7 help from a Panamanian
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- 10 First Time to Magical Saltillo Coahuila
- 11 Guanacaste
- 12 Restaurant Raves Puerto Vallarta
- 13 Riu Cancun
- 14 Help with itinerary 2 week trip to Mexico
- 15 Passport expires soon
- 16 dental implants
- 17 Los Algodones Baja Mexico
- 18 Need Suggestions for Guatemala
- 19 Santa Cruze Hualtuco
- 20 Is it really worth it to go all the way to Placencia?
- 21 day trips from Mexico City
- 22 Costa Rica - What to see with a guide vs on your own?
- 23 1st trip w/new boyfriend cancun or near by.
- 24 After Bosque del Cabo, where next?
- 25 Puerto Jiminez Costa Rica in July
Cabo Activities
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If you are there during whale season, December - March, you can go whale watching. We have also gone on a lunch/snorkel cruise with Pez Gato. Very fun. We sent our daughter and her friend on a day long zip line, rappelling, trekking with Cabo Adventures. They loved it.
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There's camel riding on the beach (I don't know why but that always cracks me up).
All the usual activities available in Cabo, like snorkeling, fishing, ziplines, trips to smaller surrounding towns (San Jose del Cabo or Todos Santos). Depending your time you can even go over to La Paz.
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text:
Fourteen Indian sailors are now safe, after pirates, who took control of their cargo vessel yesterday morning, June 5, in the Gulf of Aden, abandoned the attack hours later after EU Naval Force warship HSwMS Carlskrona, together with NATO counter piracy Dutch warship HNLMS Van Speijk, closed in.
This type of cargo vessel, known as a dhow, has been used in the past by pirates as a 'mother ship', to enable them to sail far out to sea to attack passing merchant ships.
The master of the Indian dhow had sent out an alert yesterday morning, saying that it was under attack from 12 armed pirates. Upon hearing the alert, Royal Swedish Navy warship, HSwMS Carlskrona, which has been part of the EU's counter piracy mission, Operation Atalanta, since April 6, closed the scene and as darkness fell, maintained a constant watch on the vessel.
As the Swedish helicopter from HSwMS Carlskrona overflew the scene, the pirates, now under increasing pressure from the military forces, forced the master to close the Somali coast so they could abandon the vessel in the dead of night.
Shortly afterwards, it was with a great sense of relief, that the Indian master was able to report to the EU Naval Force that all the pirates had left his ship and that none of his crew were injured.
Speaking about the incident, the Operation Commander of the EU Naval Force, Rear Admiral Bob Tarrant, said, "What is important is that fourteen Indian sailors are now safe and able to return to their families, after what must have been a terrifying ordeal. This latest attack once again shows that the threat from piracy is real. We must all remain vigilant."
Maritime Today
The Maritime Industry's original and most viewed E-News Service
1860 - The steamer USS Mystic, commanded by William E. LeRoy, captures the slaver, Thomas Achorn at Kabenda, Africa and send her to New York.
1862 - During the Civil War,
Blackmer, a company in positive displacement and centrifugal pump and reciprocating compressor technologies, has a relationship with the U.S. Military that dates
Russia and the United States gave contradictory accounts on Tuesday of an incident involving the two countries' navies in the Mediterranean Sea on June 17, each
The Red River was closed Sunday from mile marker 40 to mile marker 42, after a barge reportedly ran aground and was protruding into the channel near mile marker 41, according to the U.
A 599-foot Norway flagged chemical tanker Champion Ebony ran aground near Nunivak Island, Alaska on June 24.
U.S. Coast Guard Sector Anchorage watchstanders
China's Foreign Ministry said on Wednesday an arbitration court hearing the dispute between China and the Philippines over the South China Sea has no jurisdiction
Hybrid RoPax ferry Texelstroom has been delivered to Koninklijke N.V. Texels Eigen Stoomboot Onderneming (Royal TESO).
This latest generation symmetrical ferry is powered by efficient,
The American Waterways Operators (AWO) and ClassNK have signed an agreement under which ClassNK will be authorized to conduct audits of AWO's Responsible Carrier Program,
The U.S. Coast Guard has opened the Red River from mile marker 40 to mile marker 42 for vessel traffic, Monday.
The Red River had been closed due to a barge that had run aground at mile marker 41,
Exploration begins by BHP Billiton using the Deepwater Invictus rig and supported by Lloyd's Register's rig integrity team.
Lloyd's Register (LR) announced it


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text:
Xfce 4.6 BETA-1 ('Fuzzy') released
We are one month since the release of Xfce 4.6 ALPHA. And now it's time to release the first BETA, codename 'Fuzzy'.
A lot of bugs have been fixed in this release, a few highlights:
- Xfwm4 can now detect if a program is unresponsive. It will show a dialog to let the user kill it.
- Xfce4-session will start up significantly faster by using parallel startup.
- It is possible to configure the keyboard-layout.
- Toggling event-sounds with libcanberra + gtk 2.14 is now possible (meaning: you can turn them off).
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today's leftovers
SUSE Leftovers
The Relative Windows vs. Linux Performance For NVIDIA, Intel & AMD
Following the recent Windows vs. Linux AMDGPU-PRO / RadeonSI testing, GTX 1080 Windows vs. Linux results, and yesterday's Intel Windows vs. Linux benchmarks, here is a look at all three sets of numbers when using some OpenBenchmarking.org magic to merge the data-sets and normalize the results.


text:
You've Been Dubstepped
Take That V Jay Z – Jodie in a wind tunnel makes the 'Executive Decision' as to which one gets played
Greg James' influential superpower made Dev buy fig rolls yesterday. He brought them into work this morning to share in the studio, which kicked of the Great Cake Debate. Cakes I've never had: Welsh, Eccles, Mint, Upside Down, Christmas, Moon, Tea, Red Bean. The list is endless!
You've been dubsetpped - TV Theme Tune special: Inspector Gadget, Ghostbusters, X Files For more wob wob wob get yourself to bbc.co.uk/1xtra as it's Dubstep Week on BBC Radio 1Xtra
It's time to pick a brand new record of the week – today Dev shortlisted: Paramore / Jakwob / SBTRKT. Who will come out victorious?
Yes, we know it's early - but at least Dev's on the radio!


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Swimming NZ need a convincing argument
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No-one is saying it but Swimming New Zealand's sales patter for future funding may have to exceed their results at the Olympics.
Although New Zealand's overall performance at the London Games are being heralded a major success, Swimming New Zealand has not shared the joy after failing to secure any medals in a forgettable year in and out of the water.
In the four-year funding cycle ahead of the Olympics, Swimming NZ, which is still trying to piece together its organisation after a damning review led by former New Zealand Rugby Union chief executive Chris Moller, received $7,475,796 from Sport New Zealand.
Just how much it receives for the next cycle leading into the Rio de Janerio Games in 2016 will not be known until Sport NZ makes its "investment decisions" in December.
Swimming NZ, like the other Olympic organisations, will have to present its case in November and general manager of operations Mark O'Connor acknowledged the performance of some Kiwi swimmers was underwhelming.
"Some of the team didn't meet our expectations, that would be fair to say," he said.
Yet O'Connor is hopeful Swimming NZ will not apply a tourniquet to its funding streams after the disappointments of London.
"What we have to say to high performance Sport New Zealand is 'this is what we are aiming to do in Rio in 2016'. A number of those swimmers who went to London are Rio swimmers; people like Gareth Kean, Matthew Stanley and Natalie Wiegersma are really good 2016 targets.
"We have to work out what went wrong there [London] as an organisation and as swimmers."
While disappointed with the swim team's results Sport New Zealand high-performance chief executive Alex Baumann emphasised the distribution of future funding would not centre solely around the Olympic results.
"There's no doubt swimming under-performed and in a number of cases they were unable to repeat the times from their trials," Baumann said.
"It [future funding] is not a reward, and I want to make that clear, on Olympic performance."
Funding, however, will continue to be tight. Sports Minister Murray McCully has declared government funding for high-performance sport will be frozen for at least the next two years.
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text:
Full name Darren Papier
Born July 10, 1995
Current age 20 years 352 days
Major teams Boland Under-17s
Batting style Right-hand bat
Bowling style Right-arm medium
Education Paarl Boys High
|Bat & Bowl
|Match Date
|Boland U19s
|v Namibia U19s
|20 Dec 2013
|Other OD
|Boland U19s
|v F.State U19
|18 Dec 2013
|Other T20
|Boland U19s
|v Border U19
|17 Dec 2013
|1, 1
|Boland U19s
|v W.Prov U19
|16 Dec 2013
|12, 0/3
|Boland U17s
|v E.Prov U17s
|Cape Town
|16 Dec 2012
|Other OD
|0/15, 1
|Boland U17s
|v Nthns U17s
|Cape Town
|15 Dec 2012
|Other OD
|2/4, 21
|Boland U17s
|v NW Under-17s
|Cape Town
|14 Dec 2012
|Other T20
|15*, 2/8
|Boland U17s
|v FS Under-17s
|Cape Town
|14 Dec 2012
|Other T20
|1/16, 0
|Boland U17s
|v GTG U-17s
|Cape Town
|13 Dec 2012
|1, 16
|Boland U17s
|v Zim U-17s
|Cape Town
|12 Dec 2012
How much is a century against Zimbabwe worth? (56)
Cricket stats need to take into account various contextual factors relating to players' and teams' performances if they are to be meaningful
Why Kumble could work out better for India than Greg Chappell did (41)
He understands the Indian mentality better and doesn't have to deal with star players on the wane
'The dream is to come back and play for three to four years' (39)
Mohammad Asif is playing club cricket in Scandinavia as he strives for a Pakistan comeback and to rebuild his career in the wake of the spot-fixing scandal
More headaches for struggling South Africa (33)
As South Africa's slump gets deeper after the triangular series exit, ESPNcricinfo looks at three areas that need special focus and could possibly salvage them
What's the verdict on the pink ball in Indian conditions? (27)
Visibility is good, so is durability, and while it does swing a fair amount, it ought to spin as well


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Rescuers have retrieved 11 bodies and are searching for two missing crew members after a container ship sank off east China.
The Beihai Rescue Bureau of the Ministry of Transport dispatched two rescue vessels and a helicopter to the seawater area 40 nautical miles northeast of Longkou, Shandong Province, after the ship with 14 aboard capsized.
One crew member, who had lost consciousness, was rescued by the helicopter.
The container ship "Guangyangxingang" was on voyage from the northern coastal city of Tianjin, in the Yellow Sea, to Taizhou in eastern Zhejiang Province.
Maritime Today
The Maritime Industry's original and most viewed E-News Service
Statoil has decided to launch a large project to write the story about the company for its 50th anniversary in 2022. The University of Oslo has been chosen the
MISC Berhad (MISC) today announces the publication of its 2015 Sustainability Report, covering the Company's commitment, strategy and performance for the year ended
Jacques Vandermeiren (52) has been appointed CEO of Antwerp Port Authority as of 1 January 2017. He succeeds Eddy Bruyninckx who after 25 years at the head of the
The largest and most powerful engine from MAN Diesel & Turbo's portfolio ever designed and built has entered service.
Built by Doosan Engine in Korea and rated at 75,
Slowing growth in the size of the shipping fleet will reduce the shortage of officers over the coming years, according to the latest Manning report published by global shipping consultancy Drewry.
The Board of Directors of Matson, Inc. has appointed Stanley Kuriyama as a director of the company, effective June 23, 2016.
Kuriyama is the Executive Chairman of Alexander & Baldwin, Inc.
The second of the largest warships ever built for the U.K. Royal Navy, the Queen Elizabeth Class carrier HMS Prince of Wales, was given the royal seal of approval when HRH The Prince of Wales,
The rules of the Russian Maritime Register of Shipping are in conformity to the International Maritime Organization (IMO)goal-based standards (GBS), the IMO's Maritime
Russian development bank VEB said on Friday it had provided a guarantee for $3 billion of debt to the Yamal liquefied natural gas (LNG) project, led by Russian gas firm Novatek.
An ailing crewmember aboard the fishing vessel Seafreeze Alaska was medevaced approximately 195 miles north of Cold Bay, Alaska, Thursday.
A Coast Guard Air
Ship crews pulled more than 2,000 migrants from overcrowded boats in the Mediterranean on Friday, Italy's coastguard said, as people smugglers stepped up operations
Seven Indonesian sailors have been taken hostage in the Sulu Sea in the southern Philippines, Indonesia's foreign minister said on Friday, the latest in a string


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Wandering eyes and lustful thoughts are one thing, although those thoughts should obviously be kept in check. It's another when those thoughts are put into action. read more
Charisma Magazine
Page 33 of 121
A Practical and Biblical Understanding of Dating and Courtship
It may sound old fashioned, but take this advice from someone with a successful marriage of 34 years and five children. read more
How to Have Healthy Conversations With Your Spouse
Which type of communicator are you? How about your spouse? read more
Confession: My Child Is Failing to Meet My Expectations
When you start to think that your child doesn't measure up, then perhaps you should examine yourself. read more
5 Realizations That Can Help You Find Inner Peace
If you adopt these principles, life can be so much less stressful. read more
How God Can Heal Your Sexual Hurt
God's grace is greater than our sin or sadness. Here's what he can do for you emotionally when it comes to the area of sex. read more
3 Ways to Keep Your Marriage Strong After the Wedding
Are these things present in your marriage? If not, why not? read more
4 Ways to Raise Up Godly Girls
These suggestions will help you not only run a more peaceful household and have a better relationship with your daughters, but will also set a spiritual foundation. read more
Is There a Spiritual Side to Sex?
God created sex for the married man and woman. Shouldn't we treat it like the gift that it is? read more
10 Memory-Making Activities to Do With Your Wife
What other activities would you suggest to other husbands that would be fun and enhance their friendships with their wives? read more
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You Won't Believe the Pitch I Got From One False Prophet
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Red Carpet Recap: 2013 Pre-Oscar Party Fashion
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| February 21, 2013 - 4:33 pm
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Dec. 27, 2009, 09:17 PM
I'm fully aware that Devoucoux's, Butet's and the like are very sensitive saddles. However, do they posess any type of durability to be ridden in jeans once to twice a week maximum without being completely damaged? Most of my riding in my new saddle will be done in breeches but there are some days when jeans and half chaps will just be more convenient.
Just curious, thanks for any help!
Just curious, thanks for any help!


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We're Getting Totally Fired Up Over Burning Torch's Winter Sale
When Karyn Craven of Burning Torch opened her premiere outpost on Abbot Kinney Boulevard, we knew the most happening shopping destination in America was about to get a serious upgrade. Add in the fact that the 1,000-square-foot space was once former Jefferson Airplane member Lee Michaels' recording studio and a boxing ring where Muhammad Ali trained, and you've got the recipe for a super-stylish and historically cool hot spot.
Naturally, whenever we pay BT a visit, we end up losing track of time. Between the racks of unique up-cycled wares and copious amounts of comfy chairs, we inevitably spend more hours there than waiting in line for The Tasting Kitchen. So, we'll just chalk it up to coincidence that as we booked this weekend's brunch plans, the boutique announced that it will be hosting a winter sale with cashmere, leather, and timeless treasures up to 50% off. Bargain-loving babes can shop in person or online before Sunday, January 13 to score some of the coolest duds for half the price. Guess you'll know where to find us pre-steak and eggs!
When: Now through Sunday, January 13
Where: Burning Torch, 1627 Abbot Kinney Boulevard (between North Venice Boulevard and Rialto Avenue); 310-399-1920.
Where: Burning Torch, 1627 Abbot Kinney Boulevard (between North Venice Boulevard and Rialto Avenue); 310-399-1920.
Photo: Courtesy of Burning Torch
- Los Angeles | Burning Torch Sale - Los Angeles Clothing Discounts
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Extended Apple employee hours point to rumored July 25 Mountain Lion releasePrep work for the rollout of OS X 10.8 Mountain Lion will reportedly culminate next week when Apple employees will be be tapped for overtime beginning July 25.
In particular, corporate divisions responsible for customer service and training in the EMEA region are seeing a strong push for overtime hours for two weeks as of July 25, according to people familiar with the matter, likely portending an imminent release of Mountain Lion on or around that day.
The company will also be increasing the number of staffers available during the rumored rollout period, though the exact nature of their hire was not disclosed to them, according to those same people.
Word of the launch day arrangements comes just ten days after Apple declared OS X 10.8 gold master (GM) — a complete and ready version to be prepared for distribution. Should the product release on July 25th as expected, it would put Apple's time to market at roughly two weeks from when the software was declared GM.
AppleInsider reported in May that the Mac maker was hiring and training new staff to aid in customer support inquiries immediately following the release of Mountain Lion.
Apple's Mountain Lion webpage advertises a July launch. | Source: Apple
The new OS will feature over 200 new features including an security system that executes regular checks to keep Macs up to date with the most recent patches and updates. Some of the featured changes were outlined by AppleInsider as part of the Inside Mountain Lion series, including the iOS-style Notification Center and Voice Dictation services.
Apple last month announced that Mountain Lion would be ready for a July release, but elected not to disclose a specific release date.
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|← Previous - flaugin'
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Definition of flava
- style, individuality, and "spice" in one's personality.
I've got the flavah going on.
Last edited on May 13 2011. Submitted by Eugene from New York, NY, USA on Jan 13 1999.
- Something that is good or well liked; accepted; "kewl". (This term is an alternate spelling of "flavor." Can also be spelled "flavah".)
That guy's got the flava.
Last edited on May 13 2011. Submitted by Ashley S. from Noblesville, IN, USA on Oct 31 2002.
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Walters leads the way at Joburg Open
Round 1 highlights from the 2016 Joburg Open, where Justin Walters holds a one shot lead at 7-under.
Siem chips in for birdie on 13th hole
Marcel Siem chips in for birdie on the par-4 13th hole Thursday at the 2016 Joburg Open.
Walters eyes major spot at Joburg Open
Paige Mackenzie, Gary Williams, Charlie Rymer and Cara Robinson review the great shots of the first round at the 2016 Joburg Open. Justin Walters leads after the 1st round. Watch Morning Drive on Golf Channel.
Top 5 European Tour trophies
From a dagger to a giant clam, see the top 5 trophies on the European Tour.
Ponytail power: Siem sets early pace in France
Marcel Siem fired an opening round 65 at the 2014 Alstom Open de France.an up slope screeners as usual full week in Arizona in the US open got a baby born last Monday he. How are you guys defenders on the go for the all that's going on him. I have thought for
Chip off the block: Chip-in propels Siem to victory
Catch the action from an exciting final round at the 2014 BMW Masters.Malaren. It was a much tougher test. Best score of the day, Ross Fisher , with a 67. He had this putt for birdy, on the 72nd hole as it transpired, it would have been enough toand suddenly those putts for Fisher and Levi were very much longer. Ross Fisher first to go. Needs to hold it. Another good attempt. But from 11 back Ross Fisher misses out. No, it's He too knew as soon as he hit it that the putt wasn't good enough. So Marcel Siem with that dramatic chip in has the fourth win of his European tour career. He had only had one top ten all season before this week. But it's a win which sees him climb from fifty-third to fourth on the race to Dubai. The first winner in the final series, and what a dramatic win it was after a difficult day and the winds at lake Malaren. Marcel Siem is the BMW Masters champion .
2014 Nedbank Golf Challenge Round 1 Highlights
See highlights from the Nedbank Golf Challenge round 1. Watch Morning Drive on Golf Channel.you know, it's from the fairway. But there you see the scoring. Ross Fisher , six under par round of 66. This is a good field. A lot of top players traveled down to South Africa, to Sun City, to play in this event, as you can see by some of the names on that leaderboard. Yeah, and absolutely. I'm looking at Tim Clark there having another good showing after just coming off that playoff lost to Bubba Watson at the. Each of these are champions. That's exactly right. Another name you don't see there, but also at two under par
Siem, Coetzee in contention, eye Masters bids
Marcel Siem and George Coetzee both started well in this week's European Tour stop, with each hoping to crack the top 50 in the world with a win this week in order to earn a Masters invite.
Siem (68) dreaming of Augusta in Morocco
Marcel Siem talks about his 4-under 68 and his longshot hopes of earning a Masters invite with a victory after first-round play at 2015 Trophee Hassan II. Watch the European Tour on Golf Channel.just try hard and, and try to focus not to make any stupid mistakes . I mean, I've got the experience, I know the golf course and just, I've gotta make enough birdies, I reckon, just, just to avoid the mistakes. Well, all the best, man, and dreams
Saddier (65) takes early lead in Morocco
Morning highlights from first-round play at the 2015 Trophee Hassan II, where Adrien Saddier takes the early lead with a 7-under 65. Watch the European Tour on Golf Channel.Good start to the week. Saints call Francy Wall the Englishman. One European tour victory some fifteen years or so ago down in South Africa . He's had lots of injury problems Anthony. Got himself in a little bit of trouble finishing the other side of the course the regulation way. This was the eighteenth. That was his third into the closing par four. He would count that in as the same. Likewise, a round of 68. One better than that, George Coetzee, the man who won the Swanee Open. His second European tour event a couple of weeks ago down at Victoria Country Club . His home of course. He started at the tenth. Was going very nicely. Beautiful shot there into the seventh. Three holes from
Marcel Siem still undefeated in extra holes
Marcel Siem wins the 2014 BMW Masters in a three-man playoff with an exciting chip in. Watch Morning Drive 7AM ET.it might be Noman for the rest of the day. How about Ross Fisher , Charlie, I haven't heard his name in a little while. Yeah he had a heck of a round, shot 67 only. Four scores in the 60's and tough, tough windy conditions . Now, Marcel Siem from Germany. I love this golf Making a charge. Like we said, Lavie had a four stroke lead going into the day. We needed something to happen from behind the pack and Marcel was making the charge. And Charlie Levythere. And we have a three way playoff with Sean, Levy, and Ross . Fisher , there they are on the tee, they're gonna replay. The 18th hole, all of them right now, finding out who hits first. He's, he was holding up two fingers. It will only take one play out whole How about this little chip? This is redemption. He was four over in his incoming. Nine. And there he goes. Oh, unbelievable. The fist pump. Marcel Siem wins his fourth European tour title, Charlie, this is a player, you like the pony tail, you gotta like the game as well. Well, what, what you
Siem dislocates rib before final round; finishes T-8
Marcel Siem's unlikely bid to win the European Tour's Race to Dubai came to an end in the gym.
Golfing World: Returning McIlroy targets victory in Dubai finale
On today's Golfing World news, Rory McIlroy is paired with Henrik Stenson for the DP World Tour Championship, insisting he aims to win and crown a successful season. Sergio Garcia hires tennis champion Juan Carlos Ferrero as caddie.tee times have been announced, and last year's Race to Dubai winner, Henrik Stenson is paired with this year's winner and world number one Rory McIlroy. Marcel Siem will tee off with Jamie Donaldson and Sergio Garcia will play with Brooks Koepka who was victorious last week at the Turkish Airlines Open. Rory McIlroy is looking forward to his return to golf after a six week absence battling his former management company in a legal dispute. Rory has missed out on the first three of the final four events in the Race to Dubai series. Looking ahead to the weekend's action, he claims he will not just walk a 72 hole lap of honor. Instead he wants to finish with a win and take advantage of the jaded players from the last three events. And finally, Sergio Garcia has a new caddy for defense of next month's Thailand open. He is acquired the services of good friend and tennis champion,
Golfing World: Marcel Siem Overcomes Injury for Big Win
Golfing World chats with recent winner of the BMW Masters in China, Marcel Siem, whose victory chucked him into contention in the Race to DubaiSo, it was a playoff for the title with Levi and England's Ross Fisher . Back up the 18th zeen line just off the green. I knew I have to hold it just to stay in the


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Medical billing and coding diploma programs are one of the shorter, less demanding training programs for medical billing and coding specialists. A medical billing and coding diploma will provide you with the basic skills you need to join the medical billing and coding job market and perform the essential job duties of medical billing and coding.
Medical billing and coding diploma programs are typically offered through career and community colleges. They can usually be completed in nine months to a year.
Medical Billing and Coding Diploma Curriculum
Unlike some degree programs, diploma programs do not focus heavily on general education courses. These programs are designed to quickly train students to qualify for entry-level work as medical billers and coders. They focus mostly on typography, medical knowledge, and other core courses. Unlike certificate programs, diploma programs do not usually require prior college experience.
Most diploma programs cover subjects such as:
- Healthcare Procedures
- Medical Terminology
- Medical Coding
- Medical Reimbursement
- Computer Applications
- Clinical Simulations
For example, the 10-month medical billing and coding diploma program offered by Ultimate Medical Academy includes healthcare basics, anatomy, medical terminology, healthcare payers and claims, ICD-9-CM coding, and practice management systems. Specific courses vary from school to school.
Diploma Program Requirements
A high school diploma or a GED is normally required to enroll in a medical billing and coding diploma program.
Although not a requirement, some of the high school courses that will help you to succeed in this program include:
- Accounting
- Biology
- Physiology
- Health
- Computers
Choosing the Right Medical Billing and Coding Diploma Program
The most important step in finding the right diploma program is making sure the program is accredited.
Accreditation is a type of credential awarded to schools by regulating agencies that help ensure educational excellence. To keep their accreditation, schools have to prove that they adhere to a certain level of quality. They must, for instance, teach classes that meet basic industry standards. If you enroll in an accredited diploma program, you can be confident you will get the education you need to enter the field.
Another good reason to attend an accredited school is to obtain voluntary certification after graduation.
The three most trusted accreditations come from:
- The American Academy of Professional Coders (AAPC)
- The American Health Information Management Association (AHIMA)
- One of the six regional accreditation agencies
Medical Billing and Coding Diploma Programs Enrolling Now
Southeastern College
Southeastern College Offers Career Education Designed for Working Adults
As a student at Southeastern College, you will gain the training, skills, and knowledge you need to prepare for a rewarding career in occupations such as:
- Massage Therapy
- Medical Assisting
- Diagnostic Medical Sonography
- Pharmacy Technology
- Practical Nursing
- Surgical Technology and more
Programs vary by campus
Why Southeastern College
Our career-focused programs and flexible class schedules make Southeastern College a great choice for busy working adults. Small classes ensure personalized attention for each student, and you will gain career skills in an educational environment that simulates the workplace, so you can begin using your education immediately on the job.
Additional benefits:
- Prepare for a new career in as few as eight months
- Learn from dedicated instructors in a caring, friendly learning environment
- Financial aid is available to those who qualify
- Career placement assistance is available for graduates
Contact us today to find out more about why Southeastern College is the right choice to reach your career goals.
Southeastern College is institutionally accredited by the Accrediting Commission of Career Schools and Colleges, 2101 Wilson Blvd, Suite 302, Arlington, Virginia, 22201. Further information may be obtained by contacting the Commission at (703) 247-4212.
- West Palm Beach
- Diploma in Electronic Medical Billing and Coding Specialist
Arizona College
Arizona College prepares students to work in the "real world" of medicine. With the use of lecture and laboratory teaching, we provide our students with hands on experience. Arizona College also provides job placement services including interview techniques and preparing resumes.
Students at Arizona College can take advantage of many benefits. Arizona College students can get their resumes updated and receive job placement assistance at no charge. Whether looking for a part-time "survival" job while going through school, hoping for the right externship or looking for placement upon graduation, career development is available to help students through their search.
- Mesa
- Health Information Specialist (Billing-Coding)
Southern Careers Institute
Train for a Career the Texas Way
Southern Careers Institute has been an established Texas institution for more than 50 years, providing students with the professional skills necessary to start a career – and later advance – in their chosen field.
At SCI, we realize and embrace that each student is different. We do our best to understand every student's needs and goals, and create individual plans of action for success. From the moment you first step foot on campus through graduation and beyond, we dedicate ourselves to helping you reach further than you ever thought possible.
Are you ready to move forward? Do you want more for yourself and your family?
Click here today, and let SCI help you unlock your true potential.
Choose from the following SCI certificate programs*:
- Business Accounting Specialist
- Business Administration Assistant
- Cosmetology
- HVAC Technician
- Medical Assistant
- Medical Billing and Coding Specialist
- Medical Office Specialist
- Pharmacy Technician
At SCI, our instructors and career services staff focus on preparing you for a career after graduation. Your goals become our goals – we don't succeed until you do.
Need more reasons to choose Southern Careers Institute? At SCI, you'll have access to:
- Financial aid available for those who qualify
- Interactive, hands-on training for the real world
- Personalized attention from experienced instructors who know you by name and care about your success
- Externship and on-the-job training opportunities
- Career placement assistance
- Programs approved for VA funding
Join a Texas tradition rooted in success. Click here today to become a member of the SCI family!
- San Antonio South
- Medical Billing and Coding Specialist
Miller-Motte Technical College
You've made the decision to get more education. Find the setting that's right for you!
At Miller-Motte, we focus on offering the latest courses, and we care about the personal success of each and every one of our students. Because the marketplace demands it, we offer degrees and diplomas leading to long-term sustainable careers for our grads.
Whether preparing to enter the professional world or expanding your skills, education should be available wherever, whenever. With Miller-Motte you can rely on challenging programs, interesting curriculum, and a friendly educational environment.
- Conway
- Chattanooga
- Charleston
- Medical Billing and Coding - Diploma
Brightwood College
At Brightwood College, we offer accelerated programs that combine flexible schedules and professional instruction to create a rewarding learning experience focused on helping you gain skills for your chosen career.
We keep education relevant by employing instructors with real-world experience in the field, who bring their career backgrounds to the classroom. Our programs are continually assessed by faculty, staff and members of the business and education communities to help ensure your studies align with your career goals. Programs offered by Brightwood College focus on local employment needs, in areas such as allied health, nursing and technical and professional programs.
Within the classroom, it is our mission to not only provide vocational training, but to help you develop the professional skills, values, attitudes and strategies that will enhance your potential for success on campus, in your career and through life.
The success of our students is our greatest success. Because when our students succeed, we've completed the job we set out to do: empower the courageous, and enable real and relevant change.
- Las Vegas
- Arlington
- Dallas
- Medical Billing & Coding Specialist
Miller-Motte College
At Miller-Motte, we focus on offering the latest courses, and we care about the personal success of each and every one of our students. Because the marketplace demands it, we offer degrees and diplomas leading to long-term sustainable careers for our grads.
Whether preparing to enter the professional world or expanding your skills, education should be available wherever, whenever. With Miller-Motte you can rely on challenging programs, interesting curriculum, and a friendly educational environment.
- Greenville
- Medical Billing and Coding Specialist - Diploma
Fortis Institute
Welcome to FORTIS
At FORTIS, students are provided the skills and training needed to enter careers in industries that have employment opportunity over time. What industries you ask? FORTIS offers career education and training programs in the nursing, healthcare, medical, dental, business, information technology, skilled trades, massage and cosmetology career fields. That makes Fortis a post-secondary network of colleges and institutes with a wide variety of educational choices!
FORTIS provides education and training for qualified applicants with the desire to better their career opportunities regardless of previous educational background. Now with forty FORTIS campus locations across the country in Alabama, Arizona, Florida, Georgia, Indiana, Maryland, New Jersey, Ohio, Pennsylvania, South Carolina, Tennessee, Texas, Utah and Virginia, more students have the opportunity to experience the FORTIS Difference!
- Birmingham
- Houston North
- Lawrenceville
- Wayne
- Port St. Lucie
- Medical Billing and Coding
- Medical Billing and Coding Specialist
Florida Career College
At Florida Career College, we encourage our students to achieve their highest potential. We understand that each student learns and grows at their own pace. Our goal is to successfully prepare you for new career opportunities. We are the college that cares.
Whether you're interested in a career in healthcare, computers, cosmetology or trades, FCC is here for you! With real world equipment and training facilities, students have the added advantage of gaining hands-on experience.
Our instructors are knowledgeable in their fields and dedicated to helping you succeed. Our career services department is dedicated to helping you find a job! Many of the programs can be completed in as little as 8-9 months!*
If you don't have your High School Diploma, ask us about your options! As a student in one of our eligible career pathway programs, you'll have the opportunity to earn your High School Diploma while you complete your career training! Best of all, the opportunity to complete high school is available to you at no additional cost!**
Our schools are accredited and ready to get you started on your path to success.
Financial Aid is available for those who qualify!
**Not all programs are eligible.
Not all programs available at all locations.
*Timing varies by program. FCC – Boynton Beach, Hialeah, Jacksonville, Lauderdale Lakes, Margate, Miami, Orlando, Pembroke Pines, Tampa, and West Palm Beach are institutionally accredited by the Accrediting Council for Independent Colleges and Schools (ACICS).
- Pembroke Pines
- Boynton Beach
- West Palm Beach
- Tampa
- Margate
- Hialeah
- Miami
- Medical Front Office and Billing - DIP
Virginia College
Take your life in an exciting new direction with an education from Virginia College! Graduates of Virginia College can be confident in the skills and training that they've received because programs are designed for their success. Virginia College focuses on the needs of the job market of each industry, creating programs that meet the needs of students and future employees alike.
Virginia College provides the convenience of flexible class schedules with the benefits of small class sizes. Financial aid is available for those who qualify, helping open doors for everyone who wants to improve his or her education and opportunities!
Virginia College provides a number of choices in order to offer you the education that best fits your needs and goals, from diploma and associate degree programs to bachelor degree programs at some locations. Virginia College's school of business management even offers graduate degrees at select campuses. Programs are also offered in a number of different fields, providing choices as varied as graphic design degrees or paralegal studies. Whether you're interested in criminal justice schools or a cosmetology college, Virginia College has a choice that's right for you!
Classes Start April 6, 2016!
- Montgomery
- Fort Pierce
- Jackson
- Austin
- Medical Billing and Coding
Southern Technical College
Whether you need to upgrade your skills or change careers, we have the right program to fit your needs. Let us show you how to get the skills you need in a short amount of time so that you can get into your career today! At STC we offer hands-on clinical training, career placement assistance and morning or evening schedules.
- Southwest Campuses: Port Charlotte
- Central Campus: Mount Dora
- Diploma - Medical Billing and Coding Technology
- Medical Billing and Coding
All-State - Allied Health
All State was founded to provide you with the quality training necessary to meet your career objectives in many of the largest industries in the country ranging from Healthcare and trades to transportation. Many of the high demand industries have long recognized the need for professionally trained employees. By today's rigid standards, the old "trial and error" and on-the-job training methods are unacceptable. There's a better way!
All State is dedicated to preparing you to fill the employment opportunities available within many of these exciting industries. Our certification courses can prepare you for a lifetime of job security, stability, good income and benefits.
With All State you can achieve success. You can have a positive future, job satisfaction and financial freedom! It's as simple as committing yourself to an education at All State Career School. We do more for you then just prepare you for a job. We want you to shine, so we give you critical career skills, confidence in your abilities and the extra boost of job placement assistance.
- Essington, PA (Expanded Zip BID)
- Baltimore, MD
- Medical Billing and Coding
Vista College
Enroll in a New Future at Vista College!
Earn a Certificate, Diploma or Associate Degree in one of many careers!
Vista College offers numerous educational programs in Business, Healthcare, Technology and many other trades. Get the edge you need when looking for a new career or seeking to move up in your current occupation. The focused instruction and hands-on training offered at Vista College helps prepare you for the day-to-day challenges you'll face in the real world.
Vista College offers detailed instruction and in-depth training. We also provide additional tools you'll need to gain a competitive edge in your job search after graduation.
Take advantage of these Vista College services:
- Day or evening classes
- Learn from industry experts
- Convenient class schedules
- Career Services Assistance for graduates
- Financial aid available for those who qualify
- Plus much more!
Enroll in a fresh start today at Vista College!
Vista College is accredited by the Council on Occupational Education (COE).
Vista College is recognized as being a military friendly college through the Servicemembers Opportunities Colleges (SOC).
Programs vary by campus.
- Fort Smith
- Medical Insurance Billing and Coding
American National University
5 Reasons to Choose ANU
Affordable Education
At ANU, you may be able to apply relevant learning, work, life and military experiences toward college credits. Plus, there are many sources of financial aid from grants and loans to scholarships to employer reimbursement. All allowing you to finish your degree faster, save money, and maximize tuition-reduction options.
Start Your Career Quicker Than You Thought Possible
With 5 term starts, many of our programs allow you to start your new career in as little as 9, 12, 15 or 18 months. Classes are forming now.
Fitting College into your Schedule
At ANU, our learning formats are designed to meet the needs of working adults. You can go to college online or attend day or evening on campus classes – letting you choose when and how you want to prepare for your career.
Pathway to Life Long Learning
ANU promotes a progressive learning format, so as you earn a diploma or associate's degree, you can immediately use your training to advance your career, work for a few years, and as your career demands it, return to continue your education at the bachelor's and graduate degree levels; or you may choose to complete your education in a "straight through" manner.
Earn Credit for Work Experience
Financial Aid is available for those who qualify.
ANU allows you to apply relevant work, military service training, or life experiences towards college credits through the Advanced Placement Evaluation process or Credit by Examination Program (CLEP).
American National University is nationally accredited by the Accrediting Council for Independent Colleges and Schools (ACICS) to award on-campus and online degrees. The university has maintained its accreditation for over 60 years, providing an assurance that our degrees meet tested standards of quality recognized by employers, government agencies, and other post-secondary institutions.
- Charlottesville, VA
- Parkersburg, WV
- Medical Billing & Coding
- Medical Billing and Coding
Everest College
Everest College offers you hands-on career education in some of America's most established career fields. Benefits include:
- Programs that can be completed in as little as one year (when progressing at a normal rate), allowing you to get the training you need and into the work force as quickly as possible.
- Courses taught by instructors who are former industry professionals eager to provide you with practical insights into the subjects they teach.
- Flexible schedules designed to meet the needs of working adults and support systems designed to help you succeed both inside and outside the classroom.
- Career Services professionals who can help you find post-graduation employment opportunities in your area-a service you can access throughout your career.
- Everest is dedicated to your success today-and tomorrow!
- WA - Everett
- Medical Insurance Billing and Coding
Also see: