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Coated tissue scaffolds help the body grow new bone to repair injuries or congenital defects.
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue.
This type of coated scaffold could offer a dramatic improvement over the current standard for treating bone injuries, which involves transplanting bone from another part of the patient's body — a painful process that does not always supply enough bone. Patients with severe bone injuries, such as soldiers wounded in battle; people who suffer from congenital bone defects, such as craniomaxillofacial disorders; and patients in need of bone augmentation prior to insertion of dental implants could benefit from the new tissue scaffold, the researchers say.
"It's been a truly challenging medical problem, and we have tried to provide one way to address that problem," says Nisarg Shah, a recent PhD recipient and lead author of the paper, which appears in the Proceedings of the National Academy of Sciences this week.
Paula Hammond, the David H. Koch Professor in Engineering and a member of MIT's Koch Institute for Integrative Cancer Research and Department of Chemical Engineering, is the paper's senior author. Other authors are postdocs M. Nasim Hyder and Mohiuddin Quadir, graduate student Noémie-Manuelle Dorval Courchesne, Howard Seeherman of Restituo, Myron Nevins of the Harvard School of Dental Medicine, and Myron Spector of Brigham and Women's Hospital.
Stimulating bone growth
Two of the most important bone growth factors are platelet-derived growth factor (PDGF) and bone morphogenetic protein 2 (BMP-2). As part of the natural wound-healing cascade, PDGF is one of the first factors released immediately following a bone injury, such as a fracture. After PDGF appears, other factors, including BMP-2, help to create the right environment for bone regeneration by recruiting cells that can produce bone and forming a supportive structure, including blood vessels.
Efforts to treat bone injury with these growth factors have been hindered by the inability to effectively deliver them in a controlled manner. When very large quantities of growth factors are delivered too quickly, they are rapidly cleared from the treatment site — so they have reduced impact on tissue repair, and can also induce unwanted side effects.
"You want the growth factor to be released very slowly and with nanogram or microgram quantities, not milligram quantities," Hammond says. "You want to recruit these native adult stem cells we have in our bone marrow to go to the site of injury and then generate bone around the scaffold, and you want to generate a vascular system to go with it."
This process takes time, so ideally the growth factors would be released slowly over several days or weeks. To achieve this, the MIT team created a very thin, porous scaffold sheet coated with layers of PDGF and BMP. Using a technique called layer-by-layer assembly, they first coated the sheet with about 40 layers of BMP-2; on top of that are another 40 layers of PDGF. This allowed PDGF to be released more quickly, along with a more sustained BMP-2 release, mimicking aspects of natural healing.
"This is a major advantage for tissue engineering for bones because the release of the signaling proteins has to be slow and it has to be scheduled," says Nicholas Kotov, a professor of chemical engineering at the University of Michigan who was not part of the research team.
The scaffold sheet is about 0.1 millimeter thick; once the growth-factor coatings are applied, scaffolds can be cut from the sheet on demand, and in the appropriate size for implantation into a bone injury or defect.
Effective repair
The researchers tested the scaffold in rats with a skull defect large enough — 8 millimeters in diameter — that it could not heal on its own. After the scaffold was implanted, growth factors were released at different rates. PDGF, released during the first few days after implantation, helped initiate the wound-healing cascade and mobilize different precursor cells to the site of the wound. These cells are responsible for forming new tissue, including blood vessels, supportive vascular structures, and bone.
BMP, released more slowly, then induced some of these immature cells to become osteoblasts, which produce bone. When both growth factors were used together, these cells generated a layer of bone, as soon as two weeks after surgery, that was indistinguishable from natural bone in its appearance and mechanical properties, the researchers say.
"Using this combination allows us to not only have accelerated proliferation first, but also facilitates laying down some vascular tissue, which provides a route for both the stem cells and the precursor osteoblasts and other players to get in and do their jobs. You end up with a very uniform healed system," Hammond says.
Another advantage of this approach is that the scaffold is biodegradable and breaks down inside the body within a few weeks. The scaffold material, a polymer called PLGA, is widely used in medical treatment and can be tuned to disintegrate at a specific rate so the researchers can design it to last only as long as needed.
Hammond's team has filed a patent based on this work and now aims to begin testing the system in larger animals in hopes of eventually moving it into clinical trials.
This study was funded by the National Institutes of Health.
Sarah McDonnell | Eurek Alert!
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Belmont Learning Center
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NPR's Robert Smith reports from Los Angeles, where school district officials will decide today whether to continue building the most expensive high school in the country. The L.A. School District has already sunk about 160 million dollars into building the Belmont Learning Center, but the building site is an abandoned oil field and is the source of toxic contaminants.
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Ultimate Fighting Championship (UFC) Welterweight contender Rory MacDonald not only broke his nose in a five-round loss to Stephen Thompson back at UFC Fight Night 89, but the Canadian may have fought his last battle inside of the Octagon. After all, prior to his No. Show More Summary
Carrot Top (aka Scott Thompson) is a perpetual pop-culture target. Whether it's because of his unique look or brand of prop comedy, he takes a lot of crap. But did you know he's also one of the wealthiest comics alive? The Las VegasShow More Summary
In case you missed it because you're not Canadian, VICE Canada published a two-part series last week about the life of Carrot Top (Scott Thompson) onstage at the Luxor resort and casino in Las Vegas where he holds court with his trunks full of props and so much more, and then offstage to see what […]
Scott Coker revealed via ESPN SportsCenter that Kimbo Slice and James Thompson would meet again at Bellator 158 in London, despite Slice currently being suspended in the state of Texas for failing a drug test at Bellator 138. Fresh off Bellator MMA's first ever international card at Bellator 152 "Pitbull vs. Show More Summary
For the first time in eight years, Kimbo Slice and James Thompson will throw down in the Octagon. On Sunday, Bellator President Scott Coker announced on SportsCenter that Slice-Thompson II will take place at Bellator 158 on July 16 at the O2 Arena in London (via MMA Junkie). The two fighters met in 2008, when both were in EliteXC. Show More Summary
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Boeing last week announced a production rate cut for the 747-8, but its future remains in doubt. (AP Photo/Elaine Thompson) By Scott Hamilton Wednesday is Boeing's earnings call for the fourth quarter and full year of 2015. There continues to be three of four prime issues that overhang each earnings call, and nothing [...]
CBS-owned publisher Simon & Schuster, publisher of Ernest Hemingway, F. Scott Fitzgerald and Hunter S. Thompson, announced Sunday plans to sell a book about Taylor Swift to be crowd-sourced — that is, written and illustrated — by fans of the pop superstar, designated generational spokeswoman and best girlfriend of many. Show More Summary
James McGirt Jr. (24-3-1, 13 KOs) returned to the ring Friday night with a victory over veteran Demetrius Jenkins (8-11-2, 4 KOs). The bout took place on the undercard of Tony Thompson vs. Malik Scott at The Venue at UCF … Continue reading ? The post McGirt Jr. returns with win appeared first on Boxing News.
"He was just too fast," said heavyweight Tony Thompson (40-6, 27 KOs) after dropping a ten round unanimous decision to nine-years-younger Malik Scott (38-2-1, 13 KOs) on Friday night in Orlando, Florida. "If I were younger I would have caught … Continue reading ? The post Thompson: He was just too fast appeared first on Boxing News.
Malik Scott (38-2-1, 13 KOs) remained in the heavyweight discussion with a ten round unanimous decision over WBC #9 Tony Thompson in a crossroads fight on Friday night in Orlando, Florida. "My skill set was good, but this is one … Continue reading ? The post Malik Scott: I have to get more active appeared first on Boxing News.
ORLANDO (October 31, 2015) - Malik "King" Scott (38-2-1, 13 KOs) won a heavyweight showdown with Tony "The Tiger" Thompson (40-6, 27 KOs) on Premier Boxing Champions: The Next Round on Bounce TV Friday [...] More boxing news on BoxingNews24.com
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Malik Scott got past a scare against Tony Thompson, and prospects Gervonta Davis, Sergey Lipinets, and Samuel Figueroa picked up wins tonight on PBC. Malik Scott UD-10 Tony Thompson Thompson, 44, was awful in this fight, looking outShow More Summary
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All Times Eastern Boxing Premier Boxing Champions on Bounce, The Venue at UCF, Orlando, FL Heavyweights Tony Thompson vs. Malik Scott — Bounce TV, 9 p.m. Boxeo Telemundo, Auditorio Blackberry, Mexico City, Mexico WBO Latin Flyweight Title Gánigan López vs. Show More Summary
Photo credit: Andre Courtemanche/Warriors Boxing) By Scott Gilfoid: #9 WBC heavyweight contender Tony Thompson (40-5, 27 KOs) weighed in at 263 pounds on Thursday for his scheduled 10 round fight against [...] More boxing news on BoxingNews24.com
Photos: Andre Courtemanche/Warriors Boxing Tony Thompson 263 vs Malik Scott 235 Haskell Rhodes 138.8 vs Sergey Lipinets 139.8 Javontae Starks 148 vs Samuel Figueroa 149.2 Miguel Cruz 150 vs Anthony Abbruzzese 155.6 James McGirt Jr 162.2 vs Demetrius Walker 164 … Continue reading ? The post Weights from Orlando, Florida appeared first on Boxing News.


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Choreographer Sandip Soparrkar and his wife Jesse Randhawa, who is a model by profession, called it a quit. The couple has taken time off from the relationship to figure out things. On Saturday, the estranged issu
Bollywood twist to the Royal Wedding
The fairy-tale wedding of British royal Prince William and Kate Middleton just got a filmi twist. Sandip Soparrkar and wife Jesse Randhawa will waltz their way into the royal wedding, and this is going to be nothing like Munni or Sheila.
Jesse Randhawa
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"Star Wars Episode VII" plot leaks online: report
July 21, 2014 - 12:06 AMT
PanARMENIAN.Net - The plot of "Star Wars Episode VII", which has been kept under tight wraps, may have leaked. On Sunday, July 20, unofficial details regarding the highly-anticipated film's plot hit the web via Badass Digest, which is a generally reliable source of information, AceShowbiz said.
According to the site's Devin Faraci, the driving element of "Episode VII" is [SPOILER ALERT!] Luke Skywalker's severed hand. "A severed hand, tumbling through space. A severed hand gripping a light saber," Faraci writes.
"That hand falls onto a desert planet, where it is discovered by characters who will be our heroes. One is Daisy Ridley. The other is John Boyega, who is playing someone trying to change his path in life (again, I'm keeping it vague here). They recognize the light saber as a Jedi relic and decide to return it to the proper people," he continued.
Ridley and Boyega's characters then venture into space and later meet Han Solo and Chewbacca, "who aren't flying around in the Millenium Falcon anymore but are piloting." Han and Chewie recognize the light saber belongs to Luke, whom they haven't seen since the events of "Star Wars Episode VI: Return of the Jedi" thirty years earlier.
"So begins a quest to find the missing Jedi Master. Meanwhile, on an ice planet, nefarious forces are building a super weapon, one capable of destroying not planets but entire solar systems," he adds.
As Badass Digest notes, this plot sounds familiar because it is an echo of "Star Wars Episode IV: A New Hope". "Instead of R2 coming to Tatooine it's a hand falling from the sky, but the basic sweep of the story is similar, and intentionally so," Faraci explains.
To some fans, the plot is confusing and doesn't make any sense. Director J.J. Abrams hasn't confirmed or denied it either. The film is now in production and is scheduled to hit U.S. theaters on December 18, 2015.
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Today's Devotional
Seasons of GriefAre you going through a season of grief where you are struggling to grieve?
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I Can Only Imagine ~ Mercy Me (symphony version)
RECOMMENDATION: Drop video, turn up the volume, close your eyes and just listen!!! This is THE most powerful version of this song I have heard!!! ~ Song: I Can Only Imagine ~ By: Mercy Me ~ Album: 10 (2009) * Before I started to upload this video, I went by some precious ones to leave a few comments, and almost everyone had songs connected to heaven on their profiles. I see that times are getting darker, that days are getting tougher- but I also see God reaching out to us; MY child- remember what's ahead, remember what awaits you, some day soon you will be home, here with Me for eternity! Keep going strong, I am there with you, I will see you through! ~ I've gotten a scripture 3 days on a row now: *You will keep in perfect peace him whose mind is steadfast, because he trusts in You" (Isa.26.3) Hold on to the one holding you, one day we'll be home - and can you imagine what that will be like? I can't...


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After losing rookie Vladimir Tarasenko for an indefinite period of time, the St. Louis Blues took another hit when Andy McDonald and Alexander Steen suffered injuries during Tuesday's practice. Fortunately, McDonald shouldn't be out too long, and Steen may not miss any game action at all.
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So how do you create value from nothing for both CSC and HP by combining some stuff differently? You don't. Someone is wrong AH here and I expect these numbers to change a bunch. Gluing 2 halves of a broken pencil together does not give you 3 pencils.
MDM is a commodity so it's tough to make much margin in the mobile security business. That said, I think the market cap for this company is too low and the stock is a good buy at these levels.
Unless it's the FED/PPT buying to prop this thing up while smart money gets shorter. That's my guess.
Be careful with that assumption. Last qtr when HOG under performed this board expected PII to pick up the difference and PII missed to. We're in a recession and your customer base has very litte disposable income for the expensive toys HOG and PII make.


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Use our website's state-of-the-art search to uncover members who suit your criteria. Or just look through listings and uncover people that attract you.
Found someone who looks like a good match? Send them a few words or just a wink and take it from there. With a little luck you'll be on your way to finding that special someone for you.
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Jun 21, 2016
TEL AVIV [MENL] -- The regime of President Bashar Assad could launch massivechemical weapons attacks against Sunni rebels in 2016, a report said.
Jun 17, 2016
NICOSIA [MENL] -- Islamic State of Iraq and Levant has been expanding insoutheastern Syria.
Jun 16, 2016
WASHINGTON [MENL] -- The U.S. intelligence community has been investigatinga link between Saudi Arabia and the bloodiest shooting in American historyby Islamic State of Iraq and Levant.
Jun 13, 2016
ABU DHABI [MENL] -- The U.S. intelligence community has absolved SaudiArabia of responsibility for Al Qaida's suicide air strikes in 2001.


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Famous Stowe School Alumni
List Criteria: People on this list must have gone to Stowe School and be of some renown.
List of famous alumni from Stowe School, with photos when available. Prominent graduates from Stowe School include celebrities, politicians, business people, athletes and more. This list of distinguished Stowe School alumni is loosely ordered by relevance, so the most recognizable celebrities who attended Stowe School are at the top of the list. This directory is not just composed of graduates of this school, as some of the famous people on this list didn't necessarily earn a degree from Stowe School.
These graduates, like Henry Cavill and David Niven include images when available.
This list answers the questions "Which famous people went to Stowe School?" and "Which celebrities are Stowe School alumni?"
- 1
Sir Richard Charles Nicholas Branson is an English businessman and investor. He is best known as the founder of Virgin Group, which comprises more than 400 companies. At the age of sixteen his first business venture was a magazine called Student. In 1970, he set up a mail-order record business. In 1972, ...moremore ABOUT
- Profession: Businessperson, Television producer, Investor, Entrepreneur, Film Producer, + more
- Age: 65
- Birthplace: Blackheath, London, London, United Kingdom
- Credits: Casino Royale, Superman Returns, Around the World in 80 Days, Electric Dreams, Fuel, + more
- 2
Henry William Dalgliesh Cavill is a British actor. Cavill began his acting career starring as Albert Mondego in the 2002 film adaptation of The Count of Monte Cristo. He would later star in minor and supporting roles in television shows such as BBC's The Inspector Lynley Mysteries, Midsomer Murders and ...moremore ABOUT
- Profession: Actor
- Age: age 32
- Birthplace: Saint Saviour, Jersey
- Credits: Man of Steel, Stardust, The Count of Monte Cristo, The Tudors, Tristan & Isolde, + more
- 3
James David Graham Niven was an English actor and novelist who was popular in Europe and in the United States. He may be best known for his roles as Squadron Leader Peter Carter in A Matter of Life and Death, as Phileas Fogg in Around the World in 80 Days and as Sir Charles Lytton, a.k.a. "the Phantom", ...moremore ABOUT
- Profession: Television producer, Novelist, Actor
- Age: Died at 73 (1910-1983)
- Birthplace: England, London
- Credits: The Pink Panther, The Guns of Navarone, Around the World in Eighty Days, Stairway to Heaven
- 4
Christopher Robin Milne was the son of author A. A. Milne. As a child, he was the basis of the character Christopher Robin in his father's Winnie-the-Pooh stories and in two books of poems.moremore ABOUT
- Profession: Writer
- Age: Died at 76 (1920-1996)
- Birthplace: Chelsea, London, United Kingdom
- 5
Peter John Coke was an English actor, playwright and artist.moremore ABOUT
- Profession: Sculptor, Actor, Artist, Playwright
- Age: Died at 95 (1913-2008)
- Birthplace: Southsea, England
- Credits: The Blakes Slept Here, A Gentleman's Gentleman, The Nursemaid Who Disappeared, The Return of Carol Deane, The Broken Horseshoe
- 6
Robert Kee, CBE was a British broadcaster, journalist and writer, known for his historical works on World War II and Ireland.moremore ABOUT
- Profession: Journalist, Author, Writer, Presenter
- Age: Died at 94 (1919-2013)
- Birthplace: Kolkata, India
- 7
Chelsy Yvonne Davy is a Zimbabwean national who was the on-off girlfriend of Prince Harry from early 2004 to 2011.moremore ABOUT
- Age: age 30
- Birthplace: Bulawayo, Zimbabwe
- 8
John Fisher Locksley Burns is a British journalist, winner of two Pulitzer Prizes. He was the London bureau chief for The New York Times, where he covered international issues until March 2015. Burns also frequently appears on PBS. He has been called "the dean of American foreign correspondents." On 26 ...moremore ABOUT
- Profession: Journalist
- Age: 71
- Birthplace: Nottingham, United Kingdom
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Abbas declines meeting with Rivlin while both in Brussels
The president of the European Parliament had offered to arrange and mediate the meeting, which the Israeli president said he welcomed.
The president of the European Parliament had offered to arrange and mediate the meeting, which the Israeli president said he welcomed.
The European Jewish Congress is demanding action against Martina Anderson, who served part of a life sentence for taking part in an Irish Republican Army terrorist bombing.
"We have historical memory of what happened when Europe labelled Jewish products," Netanyahu said. More ▸
B'nai B'rith Sofia accused the Simon Wiesenthal Center of legitimizing a European Parliament member it says is an ultranationalist, though other Bulgarian Jews say he's kosher. More ▸
The demand by the E.U.'s Israel-relations czar follows a critical report on alleged irregularities in Palestinian spending. More ▸
The E.U. disowned a definition that was controversial because it lists demonization of Israel as anti-Semitism. More ▸
The nonbinding measure says recognition should go hand in hand with the development of peace talks with Israel. More ▸
"The Suppressed Years" features a confined space the size of a cattle wagon of the sort that was used in transporting tens of thousands to concentration camps. More ▸
An Egyptian activist's nomination for a prestigious European honor was withdrawn because he has called for the mass killing of Israelis. More ▸
Despite the arrest last year of its leaders, Greece's Golden Dawn made gains in European elections. Does the Greek government have a strategy for beating the neo-Nazi party? More ▸
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Goalkeeper Guillermo Ochoa made a series of outstanding saves to help Mexico hold Brazil to a thrilling 0-0 draw at the World Cup this morning.
The result leaves both teams with four points each after two games in Group A, but Brazil is ahead on goal difference going into their decisive final matches.
Croatia and Cameroon meet tomorrow for their second games after both opened with defeats.
Ochoa's first remarkable save prevented Neymar from scoring in the 26th minute. The Brazil striker's powerful header looked set to fly just inside the post when the goalkeeper dived to his right to push the ball wide.
Ochoa also made three other difficult saves to keep the hosts from breaking the deadlock - a shot by Paulinho in the 44th, a second-half effort by Neymar from inside the area and a close-range header by Thiago Silva in the 86th minute which produced a remarkable block by the Mexico keeper.
After that, there was still time for a thrilling end to the game in the northeastern city of Fortaleza. The referee dismissed Brazilian claims for a penalty after Marcelo seemed to have been grabbed in the 88th minute. Mexico then had two great chances, first with Andres Guardado's shot over the crossbar in the 90th and then with an effort by Raul Jimenez that was stopped by Brazil goalkeeper Julio Cesar in injury time.
''In the end, the 0-0 mirrors what happened, it was a very hard-fought match,'' Brazil coach Luiz Felipe Scolari said.
''The draw wasn't a good result because a victory would have already allowed us to advance, but we need to be able to respect our opponent, which played very well.''
A win by either team would have guaranteed a spot in the next round if Cameroon and Croatia were to draw in the jungle city of Manaus.
Brazil had won all three previous World Cup matches between the teams without conceding a goal, but the Latin American rivals hadn't met in the sport's showcase tournament since 1962.
It was an evenly balanced game at the Arena Castelao, with Mexico not allowing Brazil to take control. El Tri didn't play defensively and created chances throughout the match, especially with long-range shots by midfielders Hector Herrera and Jose Vazquez.
Brazil, playing without injured strike Hulk, turned up the pressure in the second half, but there was no getting past Ochoa. He denied Paulinho just before halftime, blocking the midfielder's shot after a loose ball inside the area, and then got his body in the way of Neymar's drive from inside the area. In the 86th minute, he was there on cue to block Silva's powerful header from point-blank range.
Fans wearing Brazil's green and yellow colours were the majority as expected, but Mexicans took over large seating sections of the stadium and at times were louder than the local fans. Among those in the crowd of 60,342 was NBA star Kobe Bryant, of the Los Angeles Lakers.
Brazil, the only team to play in all 20 World Cups, has reached the second round every time since 1970. Mexico is seeking to advance for its sixth straight appearance in the last 16, where it has been eliminated in the last five World Cups.
Mexico had won six of the last 10 matches, including in the final of the 2012 London Olympics, keeping the Brazilians from earning their first gold medal in football. In their latest match, Brazil won 2-0 in last year's Confederations Cup, also in Fortaleza and also in the second match of the group stage.
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This article was published online by LoveMoney.com on June 24, 2016
Link to article here
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Full series of CEP Brexit Analyses can be seen here
This article was published online by CNBC (USA) on June 24, 2016
Link to article here
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The New York Times
Turbulence and Uncertainty for the Market After 'Brexit'
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John Van Reenen webpage
Growth Programme webpage
The new London Mayor Sadiq Khan was elected in May on a platform of fairness, with commitments to a more equal London, the creation of a new economic fairness unit within the GLA and tackling low pay. In this latest blog we look at disparities in key economic outcomes (unemployment, youth unemployment, low pay, income and wealth) in London by ethnic group.
The findings are drawn from our comprehensive report on inequality and disadvantage in London published last year, The Changing Anatomy of Economic Inequality in London (2007-2013). The report provided a detailed picture of what happened to different population groups in London in the wake of the crisis and downturn. In a series of blogs we are expanding that analysis by drilling down into different aspects of inequality in London.
Other blogs in this series:
Inequalities and disadvantage in London focus on Disability
The World Bank published a blog on the work lead by STICERD director Professor Oriana Bandiera in collaboration with the IGC, UCL and BRAC, on the subject of reducing extreme poverty.
Markus Goldstein, who is lead economist in the Office of Chief Economist in the Africa Region at the World Bank, highlights the most important contributions that the recently revised paper "Labor Markets and Poverty in Village Economies" makes to the question of lifting the ultra poor.
The research, which looks at BRAC's Targeting the Ultra-Poor program implemented in Bangladesh, shows that: (i) the poor are able to take on the work activities of the non-poor but face barriers to doing so, and, (ii) one-off interventions that remove these barriers lead to sustainable poverty reduction.
In his blog, Goldsteing concludes that Professor Bandiera and her colleagues "indicate a sustainable (and cost effective see the paper for the numbers) way to break poverty traps and map a clear and sustainable trajectory out of poverty".


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In a month of pride, life after Orlando
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Summer is for swimming, at least that's what Captain Fussybuckets and Baby D think! They were so excited to review the 5' x 15" Float To Fill Ring Pool from Backyard Ocean!
This pool was easy for Daddy to fill up. All you have to do is fill the top ring with air and then fill the pool with water and it rises as it fills! It's the perfect size for Captain Fussybuckets! Baby D is still a little young, so we put him in a lifejacket, just in case. Daddy, the Captain, and Baby D all fit in the pool!
The Float To Fill Ring pool came with two inflatable beach balls, too, which was a nice suprise! It can contain 200 gallons of water and is made of three layers of vinyl for extra durability. The Float To Fill Ring Pool can be purchased currently for the sale price of $29.99 (regularly $59.99).
Check out all the pools, equipment, accessories, inflatable pools and more that Backyard Ocean has at their website!
Backyard Ocean just began a Pinterest contest called "My Sizzling Summer With Backyard Ocean!" Check out the official rules and head over to Pinterest to join the contest! You could win one of five gift certificates to Backyard Ocean!
Latest posts by Gena (see all)
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The Tale of Despereaux (original 2003; edition 2003)
by Kate Dicamillo, Timothy B Ering (Illustrator)
Work details
The Tale of Despereaux: Being the Story of a Mouse, a Princess, Some Soup and a Spool of Thread by Kate DiCamillo (2003)
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Beautiful, sad, funny, and ultimately wise, Kate DiCamillo's The Tale of Despereaux is destined, I believe, to become a childhood classic. It certainly deserved the Newbery Medal which it won! Opening with the story of the eponymous Despereaux Tilling, a tiny mouse who offends his murine community by falling in love with a human princess, thereby earning banishment to the castle dungeons, there to die at the hands of the terrible rats, the story ties together four main narrative strands. There is the aforementioned Despereaux; there is the light-addled rat Chiaroscuro - Roscuro for short - who also transgresses against the rules of his kind, and who thirsts for vengeance when he discovers how hated his kind are, out in the world of light; there is the much neglected and abused young serving girl, Miggery Sow, whose vision of hope involves becoming a princess; and then there is the Princess Pea herself, mourning for her dead mother. The fates of these four characters converge in a moving tale of longing, love and light...
Immediately engrossing as a story, this book is also a moving and thought-provoking exploration of a number of important themes. I was struck by the wisdom of the author's many asides, in which she addresses the reader directly, asking them to consider the nature of everything from love to despair, forgiveness to vengeance. I know that this style of directly addressing the reader has put some off, but I found it charming. I also thought it revealed a great respect for the child reader on the author's part, a determination to draw them into a wider world of reflection and critical thought. I found so many passages in The Tale of Despereaux moving, but I will quote just three, to give a sampling:
"Reader, you may ask this question; in fact, you must ask this question: Is it ridiculous for a very small, sickly, big-eared mouse to fall in love with a beautiful human princess named Pea?
The answer is... yes. Of course, it's ridiculous.
Love is ridiculous.
But love is also wonderful. And powerful."
"Forgiveness, reader, is, I think, something very much like hope and love, a powerful, wonderful thing.
And a ridiculous thing, too.
Isn't it ridiculous, after all, to think that a son could forgive his father for beating the drum that sent him to his death? Isn't it ridiculous to think that a mouse could ever forgive anyone for such perfidy?
But still, here are the words Despereaux Tilling spoke to his father. He said, "I forgive you, Pa."
And he said those words because he sensed that it was the only way to save his own heart, to stop it from breaking in two. Despereaux, reader, spoke those words to save himself."
"Pea was suddenly aware of how fragile her heart was, how much darkness was inside it, fighting, always, with the light. She did not like the rat. She would never like the rat, but she knew what she must do to save her own heart."
This book was so much better than The Miraculous Journey of Edward Tulane! I enjoyed it so much more!
It took me a while to get used to the narrative style of this book. I almost gave up, but Graeme Malcolm was the narrator and I love his voice, so I stuck it out. There were a lot of unnecessary asides to the reader from the narrator, and I really didn't like the portrayal of Miggery Sow. However, I really liked Despereaux as a character and ended up enjoying his portion of the story. In the end, that was enough for me.
A wonderful, sad story.
Summary: The Tale of Despereaux is divided into four sections. The first section is about a mouse named Despereaux who is born in the walls of the Kingdom of Dor. Despereaux is born with his eyes open and large ears, because of his abnormality the other mice question whether he will live or not due to his size. Despereaux learns very quickly that he is not like the other mice, he loves to explore the castle, music, reading, and a princess named Pea. The second section of tale is about the story of a rat called Roscuro, he lives in the darkness and covets a world filled with light. The third part of the tale is the story of Miggery Sow, a slow-witted serving girl who harbors a simple, impossible wish. These three characters are about to begin a journey that will lead them down into a horrible dungeon, up into a glamorous castle, and, into each other's lives.
Personal Reaction: This was one of my favorite books when I was in elementary school! The texture of the book itself was cool, the outside had jagged edges like you see in the movies. The edges were crinkled like a piece of parchment. This book is the type of book where you have to keep reading and you can't put it down until you find out what happens!
Classroom Extension Ideas: 1.) Pinpoint scenes from the book and have them explain their version of what they would do if that was them.
2. Have the class decorate the classroom as a scene from the book and explain what happened in the scene and why they chose that particular one.
This funny, original story brings four different strands into a narrative whole, with well-developed fairytale characters. There's Despereaux, the heroic young mouse who would rather read books than gnaw them; Chiaroscuro, a rat living in a dark dungeon, who aspires to a life filled with light; Miggery Sow, a serving girl who longs to be a princess; and, of course, the princess herself, who looks and acts just like the princesses in Despereaux's beloved book of fairytales.
Is contained in
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References to this work on external resources.
Wikipedia in English (2)
Amazon.com Amazon.com Review (ISBN 0763625299, Paperback)Kate DiCamillo, author of the Newbery Honor book Because of Winn-Dixie, spins a tidy tale of mice and men where she explores the "powerful, wonderful, and ridiculous" nature of love, hope, and forgiveness. Her old-fashioned, somewhat dark story, narrated "Dear Reader"-style, begins "within the walls of a castle, with the birth of a mouse." Despereaux Tilling, the new baby mouse, is different from all other mice. Sadly, the romantic, unmouselike spirit that leads the unusually tiny, large-eared mouse to the foot of the human king and the beautiful Princess Pea ultimately causes him to be banished by his own father to the foul, rat-filled dungeon.
The first book of four tells Despereaux's sad story, where he falls deeply in love with Princess Pea and meets his cruel fate. The second book introduces another creature who differs from his peers--Chiaroscuro, a rat who instead of loving the darkness of his home in the dungeon, loves the light so much he ends up in the castle& in the queen's soup. The third book describes young Miggery Sow, a girl who has been "clouted" so many times that she has cauliflower ears. Still, all the slow-witted, hard-of-hearing Mig dreams of is wearing the crown of Princess Pea. The fourth book returns to the dungeon-bound Despereaux and connects the lives of mouse, rat, girl, and princess in a dramatic denouement.
Children whose hopes and dreams burn secretly within their hearts will relate to this cast of outsiders who desire what is said to be out of their reach and dare to break "never-to-be-broken rules of conduct." Timothy Basil Ering's pencil illustrations are stunning, reflecting DiCamillo's extensive light and darkness imagery as well as the sweet, fragile nature of the tiny mouse hero who lives happily ever after. (Ages 9 and older) --Karin Snelson
(retrieved from Amazon Thu, 12 Mar 2015 17:57:50 -0400)
The adventures of Desperaux Tilling, a small mouse of unusual talents, the princess that he loves, the servant girl who longs to be a princess, and a devious rat determined to bring them all to ruin.
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4 editions of this book were published by Candlewick Press.
Editions: 0763625299, 0763617229, 0763629286, 0763640778
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13 of 13 people found the following review helpful
The story of Layton Meets Luke. More excellent puzzles.,
= Fun:
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This review is from: Professor Layton and the Last Specter - Nintendo DS (Video Game)
The story starts "in medias res" (in the middle of things), with a cut scene featuring the Spectre. Luke is acting oddly, for those familiar with the previous Layton games: Curious Village, Diabolical Box, and Unwound Future.
Turns out, this is a prequel, and Layton eventually meets Luke for the first time (since he was a baby), and soon after the scene at the beginning repeats again. Layton starts out to investigate, but a terrified Luke hugs him and stops him. Layton does stop, and addresses Luke gently. "Luke, I know you're scared, and so am I. But I need you to think calmly and rationally. Can you do that for me?" I thought this was a powerful moment. Lots of good voice acting throughout, along with the quirky art that often as hidden puzzles and hint coins (tap mailboxes, lamps, and chimneys).
The puzzles again are excellent and fresh. As a puzzle collector that has run a site called mathpuzzle for 13 years, I know fresh puzzles. The Big Book of Brainteasers is a recently released book with similar freshness. Most puzzle books are stale, with old puzzles that are fine for someone new to puzzles, but not that interesting to a puzzle fan. The Layton Series is excellent for puzzle fans due to the freshness. The puzzles are also approachable for anyone, young or old. In addition, many are interactive, and the hint system is excellent.
Highly recommended.
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Renegade Knight says:
I think your comment about puzzle freshness is an excellent & salient point to bring up. Nice job.
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This page contains Cheats for Machinarium organized by sections for iPad. This game has "Adventure" as genre, made by Amanita Design, released on Sep 8, 2011. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer: Amanita Design
- Publisher: Amanita Design
- Genre: Adventure
- Release: Sep 8, 2011
- ESRB: Not Set
If you know cheats, secrets, hints, glitches or other level guides for this game that can help others leveling up, then please Submit your Cheats and share your insights and experience with other gamers.
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
Once I enter the lobby from the elevator, the power for the switch isn't on. The light isn't on, the robot isn't on, and the lever isn't working. What do I do... Did I do...
Posted on: 06-13-2015
I was up at the fan on the lift but went back down and now I can't get back up to the fan. Am I stuck there?...
Posted on: 08-19-2014
How can I get the magnet out of inventory to aid robot to get his arm?...
Posted on: 11-30-2013
How do you get the dog with plunger gun?...
Posted on: 11-21-2012
Having trouble putting stuff in robots mouth...
Posted on: 11-12-2012
Well when u get into where can see the three cell rooms and the code to the last one is 4:45, when you get in how do u do that puzzle?...
Posted on: 10-04-2012
The System - Gameplay Video
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Star Tracks: Monday, May 16, 2016 42 years, 2,191 covers and 55,436 stories from PEOPLE magazine's history for you to enjoy
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- 4 Kids Stabbed to Death in Memphis, Police Take Mother Into Custody
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- June 09, 1980
- Vol. 13
- No. 23
For David Bergmann, Super Saucers Turned Out to Be a Close Encounter of the Lucrative Kind
Indeed, the wondrous Saucer—a foot-long, helium-filled floating pillow—hovers between floor and ceiling, bobs and weaves with air currents, follows bodies and survives up to four weeks, barring an attack from the family cat. Small wonder that its designer, David Bergmann, 29, of St. Paul, has sold 30,000 (at $2.88, plus shipping) since introducing them at the Minnesota State Fair last summer.
A self-styled "kid who never grew up," Bergmann dropped out of the local Concordia College and sold encyclopedias and shoes before going into business for himself in 1973. The firm, called Survive All and co-managed by his wife, Mary Jo, 27, sold food processors, water distillers and juicers while David tinkered, trying to develop a novelty item. When he saw son Jacy, 8, and daughter Becky, 7, go nuts over a silver Mylar helium balloon, Dad set about devising a variation that wouldn't rise to the ceiling and get stuck or run out of gas in two days. Experimenting with beads, wire and even antacid tablets taped to the sphere's bottom, he eventually brought the flotation under control with an adjustable weight system. By substituting a metallized nylon skin for the Mylar, and heat-sealing it in the same manner as packages of dehydrated food, Bergmann also extended the life of the gimmick.
An improved Super Saucer that will remain buoyant up to three months is in the works in his St. Paul storefront HQ (assembly work is farmed out to handicapped employees). But Bergmann doesn't have an immediate answer to his summer mailing woes—above 85°, inflated Saucers swell and later go limp. That, however, may prove a minor headache compared to what can happen in the heat of the night. One owner, startled out of a sound sleep, mistook his Super Saucer for an intruder and shot it. Repentant the following morning, he bought two new ones.
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The accomplishments of the University of South Carolina's (Columbia, SC) Gamecocks' coaching and players are being documented with Panasonic AJ-HPX2700 P2 HD VariCam camcorders.
The cameras are being used to shoot the coaches' show that airs on Sundays on Regional Sports Network FOX Sports South.
Gamecock Productions' two P2 HD VariCams also will be used to shoot coaches' shows for men's and women's basketball and baseball, which also will be broadcast on FOX Sports South. In a complete overhaul of production from tape-based SD to tapeless HD, Gamecock Productions — the production arm of the university's athletic department — also acquired three AG-HPX170 P2 HD handheld camcorders and an AJ-HPM200 six-slot P2 Mobile recorder.
In addition, Gamecocks' football also is using four AG-HPX370 P2 HD shoulder-mounts for coaching analysis. Gamecocks Productions tried out the HPX370s in the months leading up to its purchase of Panasonic equipment last spring.
The HPX170s are used for diverse coverage of the university's Olympics sports and to support Web streaming of a growing number of sports, including men's and women's soccer, volleyball and softball. The HPX2700s are being deployed for marketing campaigns, intro videos for stadium and arena boards, and overall specialty and stylized shooting, as well as for the coaches' shows. The P2 Mobile will be used to record games from network TV trucks at home and away and also as an ingest station.
Gamecock Productions is shooting with the HPX2700 in AVC-Intra 100 and making extensive use of the camcorder's variable frame rates.
"We can simply adjust the P2 VariCam to get the outcome we want, whether it's raw game action, epic slow motion, generic or so on," said Justin Stoll, associate director of Gamecock Productions.
Redstone Wanted To Limit Daughter's Authority
AT&T: FCC Appears Driving to Pre-Ordained BDS Destination
Moody's Says TV Biz Must Unite Vs. OTT
Correspondent Jessica Williams Departs 'The Daily Show'
Moody's: To Beat OTT, Nets Must Abandon Linear Model
AT&T Takes Issue With FCC's Biz Data Economics Report
TVBEurope and Akamai partner for multi-lingual webinar
Sky launches contract-free triple-play bundle
New small crosspoint switcher from Lawo
Rob Burnett Makes a Laugh-Out-Loud Dramedy with 'The Fundamentals of Caring'
New Lifetime Docuseries Focuses on Families of Olympic Hopefuls
FAA's New Drone Rule Gets Mixed Responses


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lifeguard jobs near Denver, CO
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Mount Vernon Country Club - Golden, CO
Communicate with other lifeguards and supervisors. Licenses / Certifications / Registrations· Lifeguard and First Aid certified· CPR/AED certification required....
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Rihm & Maurice
Ren and Stimpy fans rejoice, this series takes it up a notch!
Destructo Box
Destructo Box!
Flash Fables
These aren't your little kid's bed time stories! If they are, seek help!
My ribs are in my eyes!!!!!! Their in my eyes!!!!!
Absolutely hilarious voice-overs! Great game-play, good physics, good collisions. You should really make this longer!
Hehe... I like it!
Short, simple, challenging, and fun. Well, not too challenging. Thanks for the checkpoints!
Hell yeah!
Music from the top gear game from snes, always a win!
The Voice Acting Sells it
Short and fun game, but what keeps it memorable for me is the voice acting. The over-the-top cheesiness and script made me giggle. I also liked that I-smel could've been a dick and had far fewer checkpoints, but I think he realized this game is not meant to be challenging, just fun. Good little timekiller.
Badass game! I played thr9ough it twicce. That is freaking funny as hell! >:D


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Free Pappa Jaldi Aa Jana MP4 Video Download
Papa Jaldi Aa Jana - Taqdeer (1967)
Film was a re-make of the Konkani film "Nirmon" which also means fate starring same actress Shalini Mardolkar. Music by Lakshmikant Pyarelal is the soul of the ...
Papa Jaldi Aa Jana By Nairoz - Happy Father's Day!
"Papa jaldi aa jana" from the 1967 Hindi film "Taqdeer" sung by Nairoz. This song was composed by Laxmikant Pyarelal. The lyrics were written by Anand ...
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Song : Saat samundar paar ke...gudiyon ke baazaar se..papa jaldi aa jana.. Singer: Lata Mangeshkar, Sulakhshana Pandit, Meena Patki and Ila Desai, ...
Pappa Jaldi Aajana - Beena Chechi, Manasa, Chippi & Shreya
Pappa jaldi aajana - Beena chechi, Manasa, Chippi & Shreya.
Saat Samundar Paar Se - Best Classic Children's Lullaby Song - Shalini - Taqdeer
Enjoy listening to this melodious classic lullaby children's song, 'Saat Samundar Paar Se' from the super hit Hindi movie, 'Taqdeer' (1967) sung by Lata ...
Manasvi sings "sat samandar par se" from hindi movie "Taqdeer"
Saat Samundar Paar Se (papa Jaldi Aa Jaana) - Amitabh Singh
One song to be presented in our upcoming show... on a special request! It's very close to my heart as my niece sings it to me, "chhote Papa jaldi aa jaana.
Indian Idol Jr 2013, Sugandha, Sings Papa Jaldi Aa
Hindi Rhymes For Children - पापा जल्दी आ जाना (papa Jaldi Aa Jaana) - Hindi Balgeet
Pappa Jaldi Aa Jaana *************************************************************** Lyrics: Saat Samundar Paar Se, Gudiyo Ke Bazaar Se, Gudiya Ek Chhoti ...
Papa Jaldi Aa Jana With Lyrics - Taqdeer (1967)
Very sad song from movie Taqdeer. The song is on Father. Pappa Jaldi Aa Jana.
This video was uploaded from an Android phone.
Papa Jaldi Aa Jana Taqdeer 1967
saat samundar paar ke gudiyo ke baazaar se achhi si gudiya laana gudiya chaahe na laana pappa jaldi aa jaana tum pardes gaye jab se bas ye haal hua tab ...
Pappa Jaldi Aajana - (taqdeer1967)- Happy Father's Day To All Fathers (info) 21st June
this song i am singing for the second time , love and cherish this number very much . brings me good old memories of my childhood with my late loving father ...
12 Papa Jaldi Aajana By Rajesh Singhpuriya(varun Music Video)
L'il Champs 2009 September 12, 2009 Prateeksha Srivastava
Watch latest "Sa Re Ga Ma Pa L'il Champs 2009" webisodes on http://www.zeetv.com.
cute play by students of ayushman Convent School Garampani, Nainital at Anubhav 2014-the Annual function.
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We miss you papa, love you and InshaAllah will meet very soon and will live together forever.
Saat Samundar Paar Se Gudiyo Ke Bazaar Se - Lata Mangeshkar Songs - Laxmikant Pyarelal Hit Songs
Song: Saat Samundar Paar Se Gudiyo Ke Bazaar Se (Papa Jaldi Aa Jana) Movie: Taqdeer Singer: Lata Mangeshkar, Sulakshana Pandit Music: Laxmikant ...


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It is a mistake to assume that content development is an assumed talent, or that it can be an afterthought in the digital marketing realm. Content strategy is more than writing for the web. There is a science and strategy behind developing quality content for web pages, blogs, advertisements and social media. And although every successful copywriter must have a foundation of basics writing skills, such as subject matter expertise, an engaging style and tone, and basic grammar usage, there is much more to being a content king.
Mar 09, 2004
Percussion Software has introduced version 2 of Lyrix, its Lotus Domino content integration product. Lyrix 2 is designed to enable direct, out-of-the-box reuse of Domino content throughout the enterprise. Based on a Web services architecture, Lyrix 2 converts Domino content into formats accepted by J2EE and .NET applications. It is designed to play a key role in any organization's Domino content strategy, regardless of their current
use or future plans for their Domino applications. Version 2 will be available next
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Today's Devotional
Always ThereDo you believe that the Lord is always with you?
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