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Rocks Across the Pond
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Perspectives on the journey of a Baseball Parent - From Little League, to the World Series, and everything in-between. From the start in 1989 as parents of then 6 year old Justin Verlander and later his younger brother Ben, and with little background or experience in any type of organised sports ourselves, we had no idea about the turn our lives were about to take when a n ...more
Hardcover, 95 pages
Published May 1st 2012 by Dementi Milestone Publishing
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Aug 06, 2012 Nick rated it really liked it
I got this from the library for my son. He wanted a biography of Justin Verlander and this was all we could find. It was such a gorgeous book I decided to read it even though I'm not much for baseball. The reminiscing parts of this book are touching. The how to raise a child parts I could have done without. Not that there was anything that I necessarily disagreed with, it just didn't seem the place. Without all the great photos this would be a 3. As a side note, the only interest my son had in t ...more
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Local Chinese Language and Culture resources:
University of MN - Offers many resources for those interest in China. A starting point is www.chinacenter.umn.edu. Don't forget their bookstore for Chinese language text books.
Tandem at U of M - Tandem/Tandem Plus, a University of Minnesota program to connect people learning a language with a native speaker who wants to learn your native language. A win win for both Tandem UofM.
Chinese American Association MN (CAAM) - Local organization that among other things runs a Chinese language school that meets on Saturday mornings. The school is mainly for children, but there are adult classes. www.caam.org
Taiwanese American Association Minnesota (TAAMN) - Local organization. www.taamn.org
Minnesota Community Technical College - They just started having Chinese language classes in the fall of 2006. At least some of the classes were in the evening. www.minneapolis.edu
MinHua.com - They offer classes for native and non-native Chinese speakers and both child and adult classes. www.minhua.com
Yinghua Academy - Yinghua Academy is the first Chinese immersion school in the Midwest – and the first Chinese immersion charter public school in the U.S. www.yinghuaacademy.org
Minnesota China Academy - The mission of Minnesota China Academy is to teach Chinese language, culture, arts and other related subjects, with its main focus on students who do not have a Chinese language background at home. www.mnchinaacademy.org
MinnesotaChinese.com - A website for Chinese in Minnesota www.MinnesotaChinese.com
Minneaoplis Institute of Arts - They have a large collection of Chinese art and artifacts. www.artsmia.org
Chinese Language and Culture Resources on the Internet:
www.chinesepod.com - Chinese language lessons with audio. Pod casts are free, but for a small monthly fee you can get text in English, pin yin, and traditional and simplified characters to go along with the pod casts. Lessons are at four different levels of proficiency. Updated daily.
www.china.org.cn - Chinese language lessons with audio.
www.yellowbridge.com - Various Chinese Language resources including a dictionary.
www.pzlabs.com - Online English-to-Chinese or Chinese-to-English dictionary. A little rough, but it works.
www.zgbriefs.com - Sign up for a weekly e-mail newsletter with summaries of news articles about China from various sources.
www.chinasprout.com - Online shopping for Chinese items. Mainly kids stuff, though not all.
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When primary and secondary endpoints in a clinical trial with patients suffering from a chronic disease, statistical models for time-to-event data are commonly used and accepted. This is in contrast to the analysis of data on adverse events where often only a table with observed frequencies and corresponding test statistics is reported. An example is the recently published CLEOPATRA study where a three-drug regimen is compared with a two-drug regimen in patients with HER2-positive first-line metastatic breast cancer. Here, as described earlier, primary and secondary endpoints (progression-free and overall survival) are analysed using time-to-event models, whereas adverse events are summarized in a simple frequency table, although the duration of study treatment differs substantially. In this paper, we demonstrate the application of time-to-event models to first serious adverse events using the data of the CLEOPATRA study. This will cover the broad range between a simple incidence rate approach over survival and competing risks models (with death as a competing event) to multi-state models. We illustrate all approaches by means of graphical displays highlighting the temporal dynamics and compare the obtained results. For the CLEOPATRA study, the resulting hazard ratios are all in the same order of magnitude. But the use of time-to-event models provides valuable and additional information that would potentially be overlooked by only presenting incidence proportions. These models adequately address the temporal dynamics of serious adverse events as well as death of patients. Copyright © 2016 John Wiley & Sons, Ltd.]]>
The goals of phase II clinical trials are to gain important information about the performance of novel treatments and decide whether to conduct a larger phase III trial. This can be complicated in cases when the phase II trial objective is to identify a novel treatment having several factors. Such multifactor treatment scenarios can be explored using fixed sample size trials. However, the alternative design could be response adaptive randomization with interim analyses and additionally, longitudinal modeling whereby more data could be used in the estimation process. This combined approach allows a quicker and more responsive adaptation to early estimates of later endpoints. Such alternative clinical trial designs are potentially more powerful, faster, and smaller than fixed randomized designs. Such designs are particularly challenging, however, because phase II trials tend to be smaller than subsequent confirmatory phase III trials. The phase II trial may need to explore a large number of treatment variations to ensure that the efficacy of optimal clinical conditions is not overlooked. Adaptive trial designs need to be carefully evaluated to understand how they will perform and to take full advantage of their potential benefits. This manuscript discusses a Bayesian response adaptive randomization design with a longitudinal model that uses a multifactor approach for predicting phase III study success via the phase II data. The approach is based on an actual clinical trial design for the hyperbaric oxygen brain injury treatment trial. Specific details of the thought process and the models informing the trial design are provided. Copyright © 2016 John Wiley & Sons, Ltd.]]>
In this paper, we propose a multistage group sequential procedure to design survival trials using historical controls. The formula for the number of events required for historical control trial designs is derived. Furthermore, a transformed information time is proposed for trial monitoring. An example is given to illustrate the application of the proposed methods to survival trial designs using historical controls. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Simple descriptive listings and inference statistics based on 2×2 tables are still the most common way of summarizing and reporting adverse events data from randomized controlled trials, although these methods do not account for differences in observation times between treatment groups. Using standard methods from survival analysis such as the Cox model or Kaplan–Meier estimates would overcome this problem but limit the analysis to the first safety-related event of each subject. As an alternative, we discuss two models for recurrent events data—the Andersen–Gill and Prentice–Williams–Peterson model—regarding their applicability to safety data from randomized controlled trials. We argue that these models can be used to estimate two different quantities: a direct treatment effect on the risk of an event (Prentice–Williams–Peterson) and a total treatment effect as sum of the direct effect and the treatment's indirect effect via the event history (Anderson–Gill). Using simulated data, we illustrate the difference between these treatment effects and analyze the performance of both models in different scenarios. Because both models are limited to the analysis of cause-specific hazards if competing risks are present, we suggest to incorporate estimates of the mean frequency of events in the analysis to additionally allow the comparison of treatment effects on absolute event probabilities. We demonstrate the application of both models and the mean frequency function to safety endpoints with an illustrative analysis of data from a randomized phase-III study. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Conventionally, adaptive phase II/III clinical trials are carried out with a strict two-stage design. Recently, a varying-stage adaptive phase II/III clinical trial design has been developed. In this design, following the first stage, an intermediate stage can be adaptively added to obtain more data, so that a more informative decision can be made. Therefore, the number of further investigational stages is determined based upon data accumulated to the interim analysis. This design considers two plausible study endpoints, with one of them initially designated as the primary endpoint. Based on interim results, another endpoint can be switched as the primary endpoint. However, in many therapeutic areas, the primary study endpoint is well established. Therefore, we modify this design to consider one study endpoint only so that it may be more readily applicable in real clinical trial designs. Our simulations show that, the same as the original design, this modified design controls the Type I error rate, and the design parameters such as the threshold probability for the two-stage setting and the alpha allocation ratio in the two-stage setting versus the three-stage setting have a great impact on the design characteristics. However, this modified design requires a larger sample size for the initial stage, and the probability of futility becomes much higher when the threshold probability for the two-stage setting gets smaller. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Decision theory is applied to the general problem of comparing two treatments in an experiment with subjects assigned to the treatments at random. The inferential agenda covers collection of evidence about superiority, non-inferiority and average bioequivalence of the treatments. The proposed approach requires defining the terms 'small' and 'large' to qualify the magnitude of the treatment effect and specifying the losses (or loss functions) that quantify the consequences of the incorrect conclusions. We argue that any analysis that ignores these two inputs is deficient, and so is any ad hoc way of taking them into account. Sample size calculation for studies intended to be analysed by this approach is also discussed. Copyright © 2016 John Wiley & Sons, Ltd.]]>
By examining the outcome trajectories of the dropout patients with different reasons in the schizophrenia trials, we note that although patients are recruited from the same protocol that have compatible baseline characteristics, they may respond differently even to the same treatment. Some patients show consistent improvement while others only have temporary relief. This creates different patient subpopulations characterized by their response and dropout patterns. At the same time, those who continue to improve seem to be more likely to complete the study while those who only experience temporary relief have a higher chance to drop out. Such phenomenon appears to be quite general in schizophrenia clinical trials. This simultaneous inhomogeneity both in patient response as well as dropout patterns creates a scenario of missing not at random and therefore results in biases when we use the statistical methods based on the missing at random assumption to test treatment efficacy. In this paper, we propose to use the latent class growth mixture model, which is a special case of the latent mixture model, to conduct the statistical analyses in such situation. This model allows us to take the inhomogeneity among subpopulations into consideration to make more accurate inferences on the treatment effect at any visit time. Comparing with the conventional statistical methods such as mixed-effects model for repeated measures, we demonstrate through simulations that the proposed latent mixture model approach gives better control on the Type I error rate in testing treatment effect. Published 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.]]>
Multiplicity is common in clinical studies and the current standard is to use the familywise error rate to ensure that the errors are kept at a prespecified level. In this paper, we will show that, in certain situations, familywise error rate control does not account for all errors made. To counteract this problem, we propose the use of the expected number of false claims (EFC). We will show that a (weighted) Bonferroni approach can be used to control the EFC, discuss how a study that uses the EFC can be powered for co-primary, exchangeable, and hierarchical endpoints, and show how the weight for the weighted Bonferroni test can be determined in this manner. ©2016 The Authors. Pharmaceutical Statistics Published by John Wiley & Sons Ltd.]]>
The development of novel therapies in multiple sclerosis (MS) is one area where a range of surrogate outcomes are used in various stages of clinical research. While the aim of treatments in MS is to prevent disability, a clinical trial for evaluating a drugs effect on disability progression would require a large sample of patients with many years of follow-up. The early stage of MS is characterized by relapses. To reduce study size and duration, clinical relapses are accepted as primary endpoints in phase III trials. For phase II studies, the primary outcomes are typically lesion counts based on magnetic resonance imaging (MRI), as these are considerably more sensitive than clinical measures for detecting MS activity. Recently, Sormani and colleagues in 'Surrogate endpoints for EDSS worsening in multiple sclerosis' provided a systematic review and used weighted regression analyses to examine the role of either MRI lesions or relapses as trial level surrogate outcomes for disability. We build on this work by developing a Bayesian three-level model, accommodating the two surrogates and the disability endpoint, and properly taking into account that treatment effects are estimated with errors. Specifically, a combination of treatment effects based on MRI lesion count outcomes and clinical relapse was used to develop a study-level surrogate outcome model for the corresponding treatment effects based on disability progression. While the primary aim for developing this model was to support decision-making in drug development, the proposed model may also be considered for future validation. Copyright © 2016 John Wiley & Sons, Ltd.]]>
ICH E9 Statistical Principles for Clinical Trials was issued in 1998. In October 2014, an addendum to ICH E9 was proposed relating to estimands and sensitivity analyses. In preparation for the release of the addendum, Statisticians in the Pharmaceutical Industry held a 1-day expert group meeting in February 2015. Topics debated included definition, development, implementation, education and communication challenges associated with estimands and sensitivity analyses. The topic of estimands is an important and relatively new one in clinical development. A clear message from the meeting was that estimands bridge the gap between study objectives and statistical methods. When defining estimands, an iterative process linking trial objectives, estimands, trial design, statistical and sensitivity analysis needs to be established. Each objective should have at least one distinct estimand, supported by sensitivity analyses. Because clinical trials are multi-faceted and expensive, it is unrealistic to restrict a study to a single objective and associated estimand. The actual set of estimands and sensitivity analyses for a study will depend on the study objectives, the disease setting and the needs of the various stakeholders. Copyright © 2016 John Wiley & Sons, Ltd.]]>
In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. Such targeted trials require designs that allow for stratification based on the participants' molecular characterisation. A targeted design proposed by Jones and Holmgren (JH) Jones CL, Holmgren E: 'An adaptive Simon two-stage design for phase 2 studies of targeted therapies', Contemporary Clinical Trials 28 (2007) 654-661.determines whether a drug only has activity in a disease sub-population or in the wider disease population. Their adaptive design uses results from a single interim analysis to decide whether to enrich the study population with a subgroup or not; it is based on two parallel Simon two-stage designs. We study the JH design in detail and extend it by providing a few alternative ways to control the familywise error rate, in the weak sense as well as the strong sense. We also introduce a novel optimal design by minimising the expected sample size. Our extended design contributes to the much needed framework for conducting Phase II trials in stratified medicine. © 2016 The Authors Pharmaceutical Statistics Published by JohnWiley & Sons Ltd]]>
The aim of this work is to shed some light on common issues in the statistical analysis of adverse events (AEs) in clinical trials, when the main outcome is a time-to-event endpoint. To begin, we show that AEs are always subject to competing risks. That is, the occurrence of a certain AE may be precluded by occurrence of the main time-to-event outcome or by occurrence of another (fatal) AE. This has raised concerns on 'informative' censoring. We show that, in general, neither simple proportions nor Kaplan–Meier estimates of AE occurrence should be used, but common survival techniques for hazards that censor the competing event are still valid, but incomplete analyses. They must be complemented by an analogous analysis of the competing event for inference on the cumulative AE probability. The commonly used incidence rate (or incidence density) is a valid estimator of the AE hazard assuming it to be time constant. An estimator of the cumulative AE probability can be derived if the incidence rate of AE is combined with an estimator of the competing hazard. We discuss less restrictive analyses using non-parametric and semi-parametric approaches. We first consider time-to-first-AE analyses and then briefly discuss how they can be extended to the analysis of recurrent AEs. We will give a practical presentation with illustration of the methods by a simple example. Copyright © 2016 John Wiley & Sons, Ltd.]]>
The analysis of adverse events plays an important role in the benefit assessment of drugs. Consequently, results on adverse events are an integral part of reimbursement dossiers submitted by pharmaceutical companies to health policy decision-makers. Methods applied in the analysis of adverse events commonly include simple standard methods for contingency tables. However, the results produced may be misleading if observations are censored at the time of discontinuation due to treatment switching or noncompliance, resulting in unequal follow-up periods. In this paper, we present examples to show that the application of inadequate methods for the analysis of adverse events in the reimbursement dossier can lead to a downgrading of the evidence on a drug's benefit in the subsequent assessment, as greater harm from the drug cannot be excluded with sufficient certainty. Legal regulations on the benefit assessment of drugs in Germany are presented, in particular, with regard to the analysis of adverse events. Differences in safety considerations between the drug approval process and the benefit assessment are discussed. We show that the naive application of simple proportions in reimbursement dossiers frequently leads to uninterpretable results if observations are censored and the average follow-up periods differ between treatment groups. Likewise, the application of incidence rates may be misleading in the case of recurrent events and unequal follow-up periods. To allow for an appropriate benefit assessment of drugs, adequate survival time methods accounting for time dependencies and duration of follow-up are required, not only for time-to-event efficacy endpoints but also for adverse events. Copyright © © 2016 The Authors. Pharmaceutical Statistics published by JohnWiley & Sons Ltd.]]>
The conduct of structured benefit–risk assessment (BRA) of pharmaceutical products is a key area of interest for regulatory agencies and the pharmaceutical industry. However, the acceptance of a standardized approach and implementation are slow. Statisticians play major roles in these organizations, and have a great opportunity to be involved and drive the shaping of future BRA.
We performed a literature search of recent reviews and initiatives assessing BRA methodologies, and grouped them to assist those new to BRA in learning, understanding, and choosing methodologies. We summarized the key points and discussed the impact of this emerging field on various stakeholders, particularly statisticians in the pharmaceutical industry.
We provide introductory, essential, special interest, and further information and initiatives materials that direct readers to the most relevant materials, which were published between 2000 and 2013. Based on recommendations in these materials we supply a toolkit of advocated BRA methodologies.
Despite initiatives promoting these methodologies, there are still barriers, one of which being the lack of a consensus on the most appropriate methodologies among stakeholders. However, this opens up opportunities, for statisticians in the pharmaceutical industry especially, to champion appropriate BRA methodology use throughout the pharmaceutical product lifecycle.
This article may serve as a starting point for discussions and to reach a mutual consensus for methodology selection in a particular situation. Regulators and pharmaceutical industry should continue to collaborate to develop and take forward BRA methodologies, and by clear communication develop a mutual understanding of the key issues. Copyright © 2015 John Wiley & Sons, Ltd.
No abstract is available for this article.
For clinical trials with time-to-event endpoints, predicting the accrual of the events of interest with precision is critical in determining the timing of interim and final analyses. For example, overall survival (OS) is often chosen as the primary efficacy endpoint in oncology studies, with planned interim and final analyses at a pre-specified number of deaths. Often, correlated surrogate information, such as time-to-progression (TTP) and progression-free survival, are also collected as secondary efficacy endpoints. It would be appealing to borrow strength from the surrogate information to improve the precision of the analysis time prediction. Currently available methods in the literature for predicting analysis timings do not consider utilizing the surrogate information. In this article, using OS and TTP as an example, a general parametric model for OS and TTP is proposed, with the assumption that disease progression could change the course of the overall survival. Progression-free survival, related both to OS and TTP, will be handled separately, as it can be derived from OS and TTP. The authors seek to develop a prediction procedure using a Bayesian method and provide detailed implementation strategies under certain assumptions. Simulations are performed to evaluate the performance of the proposed method. An application to a real study is also provided. Copyright © 2015 John Wiley & Sons, Ltd.]]>
We consider the blinded sample size re-estimation based on the simple one-sample variance estimator at an interim analysis. We characterize the exact distribution of the standard two-sample t-test statistic at the final analysis. We describe a simulation algorithm for the evaluation of the probability of rejecting the null hypothesis at given treatment effect. We compare the blinded sample size re-estimation method with two unblinded methods with respect to the empirical type I error, the empirical power, and the empirical distribution of the standard deviation estimator and final sample size. We characterize the type I error inflation across the range of standardized non-inferiority margin for non-inferiority trials, and derive the adjusted significance level to ensure type I error control for given sample size of the internal pilot study. We show that the adjusted significance level increases as the sample size of the internal pilot study increases. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Over the past years, significant progress has been made in developing statistically rigorous methods to implement clinically interpretable sensitivity analyses for assumptions about the missingness mechanism in clinical trials for continuous and (to a lesser extent) for binary or categorical endpoints. Studies with time-to-event outcomes have received much less attention. However, such studies can be similarly challenged with respect to the robustness and integrity of primary analysis conclusions when a substantial number of subjects withdraw from treatment prematurely prior to experiencing an event of interest. We discuss how the methods that are widely used for primary analyses of time-to-event outcomes could be extended in a clinically meaningful and interpretable way to stress-test the assumption of ignorable censoring. We focus on a 'tipping point' approach, the objective of which is to postulate sensitivity parameters with a clear clinical interpretation and to identify a setting of these parameters unfavorable enough towards the experimental treatment to nullify a conclusion that was favorable to that treatment. Robustness of primary analysis results can then be assessed based on clinical plausibility of the scenario represented by the tipping point. We study several approaches for conducting such analyses based on multiple imputation using parametric, semi-parametric, and non-parametric imputation models and evaluate their operating characteristics via simulation. We argue that these methods are valuable tools for sensitivity analyses of time-to-event data and conclude that the method based on piecewise exponential imputation model of survival has some advantages over other methods studied here. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Statistical meta-analysis is mostly carried out with the help of the random effect normal model, including the case of discrete random variables. We argue that the normal approximation is not always able to adequately capture the underlying uncertainty of the original discrete data. Furthermore, when we examine the influence of the prior distributions considered, in the presence of rare events, the results from this approximation can be very poor. In order to assess the robustness of the quantities of interest in meta-analysis with respect to the choice of priors, this paper proposes an alternative Bayesian model for binomial random variables with several zero responses. Particular attention is paid to the coherence between the prior distributions of the study model parameters and the meta-parameter. Thus, our method introduces a simple way to examine the sensitivity of these quantities to the structure dependence selected for study. For illustrative purposes, an example with real data is analysed, using the proposed Bayesian meta-analysis model for binomial sparse data. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Clinical trials are often designed to compare continuous non-normal outcomes. The conventional statistical method for such a comparison is a non-parametric Mann–Whitney test, which provides a P-value for testing the hypothesis that the distributions of both treatment groups are identical, but does not provide a simple and straightforward estimate of treatment effect. For that, Hodges and Lehmann proposed estimating the shift parameter between two populations and its confidence interval (CI). However, such a shift parameter does not have a straightforward interpretation, and its CI contains zero in some cases when Mann–Whitney test produces a significant result. To overcome the aforementioned problems, we introduce the use of the win ratio for analysing such data. Patients in the new and control treatment are formed into all possible pairs. For each pair, the new treatment patient is labelled a 'winner' or a 'loser' if it is known who had the more favourable outcome. The win ratio is the total number of winners divided by the total numbers of losers. A 95% CI for the win ratio can be obtained using the bootstrap method. Statistical properties of the win ratio statistic are investigated using two real trial data sets and six simulation studies. Results show that the win ratio method has about the same power as the Mann–Whitney method. We recommend the use of the win ratio method for estimating the treatment effect (and CI) and the Mann–Whitney method for calculating the P-value for comparing continuous non-Normal outcomes when the amount of tied pairs is small. Copyright © 2016 John Wiley & Sons, Ltd.]]>
The mean residual life (MRL) function is one of the basic parameters of interest in survival analysis that describes the expected remaining time of an individual after a certain age. The study of changes in the MRL function is practical and interesting because it may help us to identify some factors such as age and gender that may influence the remaining lifetimes of patients after receiving a certain surgery. In this paper, we propose a detection procedure based on the empirical likelihood for the changes in MRL functions with right censored data. Two real examples are also given: Veterans' administration lung cancer study and Stanford heart transplant to illustrate the detecting procedure. Copyright © 2016 John Wiley & Sons, Ltd.]]>
This paper illustrates an approach to setting the decision framework for a study in early clinical drug development. It shows how the criteria for a go and a stop decision are calculated based on pre-specified target and lower reference values. The framework can lead to a three-outcome approach by including a consider zone; this could enable smaller studies to be performed in early development, with other information either external to or within the study used to reach a go or stop decision. In this way, Phase I/II trials can be geared towards providing actionable decision-making rather than the traditional focus on statistical significance. The example provided illustrates how the decision criteria were calculated for a Phase II study, including an interim analysis, and how the operating characteristics were assessed to ensure the decision criteria were robust. Copyright © 2016 John Wiley & Sons, Ltd.]]>
In current industry practice, it is difficult to assess QT effects at potential therapeutic doses based on Phase I dose-escalation trials in oncology due to data scarcity, particularly in combinations trials. In this paper, we propose to use dose-concentration and concentration-QT models jointly to model the exposures and effects of multiple drugs in combination. The fitted models then can be used to make early predictions for QT prolongation to aid choosing recommended dose combinations for further investigation. The models consider potential correlation between concentrations of test drugs and potential drug–drug interactions at PK and QT levels. In addition, this approach allows for the assessment of the probability of QT prolongation exceeding given thresholds of clinical significance. The performance of this approach was examined via simulation under practical scenarios for dose-escalation trials for a combination of two drugs. The simulation results show that invaluable information of QT effects at therapeutic dose combinations can be gained by the proposed approaches. Early detection of dose combinations with substantial QT prolongation is evaluated effectively through the CIs of the predicted peak QT prolongation at each dose combination. Furthermore, the probability of QT prolongation exceeding a certain threshold is also computed to support early detection of safety signals while accounting for uncertainty associated with data from Phase I studies. While the prediction of QT effects is sensitive to the dose escalation process, the sensitivity and limited sample size should be considered when providing support to the decision-making process for further developing certain dose combinations. Copyright © 2016 John Wiley & Sons, Ltd.]]>
Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repeated in vivo studies where there is a considerable amount of data from historical control groups, which has potential value. This paper describes our experience with introducing Bayesian analysis for such studies using a Bayesian meta-analytic predictive approach. This leads naturally either to an informative prior for a control group as part of a full Bayesian analysis of the next study or using a predictive distribution to replace a control group entirely. We use quality control charts to illustrate study-to-study variation to the scientists and describe informative priors in terms of their approximate effective numbers of animals. We describe two case studies of animal models: the lipopolysaccharide-induced cytokine release model used in inflammation and the novel object recognition model used to screen cognitive enhancers, both of which show the advantage of a Bayesian approach over the standard frequentist analysis. We conclude that using Bayesian methods in stable repeated in vivo studies can result in a more effective use of animals, either by reducing the total number of animals used or by increasing the precision of key treatment differences. This will lead to clearer results and supports the "3Rs initiative" to Refine, Reduce and Replace animals in research. Copyright © 2016 John Wiley & Sons, Ltd.]]>


text:
Cheers to choccy for sending me the original mail that ended up being this web page. I've turned it into a little program that does the random selection for you. No idea who the original author was, sorry!
For the next verse, simply click your browser's "reload" button. Keep singing!
I met her outside Fresno poppin' uppers,
I can still recall that creepy smile she wore.
She was drinkin' Dr. Pepper with a wetback,
and I knew that she would be a crashing bore.
I knew deep down I'd warp her mind forever,
She said to me there was no other guy,
But who'd have thought she'd grovel in her Maytag,
She freaked out on the lawn and screamed goodbye.
This stuff is maintained by
Nick Waterman
Email Me


text:
There I was at CVS trying to find a Hallmark sentiment to convey to my new friends Mary and Larry what an inspiration their ten-year marriage has been to me. Larry and Mary were the quintessential California fairy tale couple -- tanned and toned with stunning good looks, a gorgeous tow-headed two year old, and lots of love evident for each other. But cards celebrating a successful marriage have an awful way of gravitating towards mention of a "happy home." Like this one:
May the love in your hearts mirror the laughter in your home.
Or my favorite:
Marriage is
Vacuuming carpets and hammering nails.
It's balancing checkbooks and paying off bills
it's cleaning the windows and mopping up spills.
I wouldn't have been so sensitive to the nearly ubiquitous overlap between marriage and home except that Larry and Mary are currently homeless.
I met Mary and Larry three months ago when I was researching a story on the hidden homeless living here in Los Angeles.
These are people with middle-class backgrounds and high paying jobs who got sucker punched by the economic downturn and found themselves literally on the streets. In Larry and Mary's case they lost their jobs in construction and real estate respectively. After years of double incomes, flipping houses and acquiring the accouterments of the successful turn of the century power couple, the journey from a house in Santa Barbara with a white picket fence and a BMW to friends' couches to a homeless shelter was surprisingly swift. They never thought it could happen to them.
With a home no longer in the picture, the struggle to maintain a fairy tale marriage becomes its own epic odyssey. Thanks in large part to a unique shelter that allowed them to live together with their child for the next year and offers financial workshops, marriage counseling and the tools necessary to start over, Larry and Mary will make it. Now they appreciate every little thing in their lives and take nothing for granted. Larry is slowly but surely getting more contract jobs and Mary just got a seasonal job at Macy's. But most importantly, they have each other. The fact that they stayed together through it all speaks volumes about the true meaning of "for richer or poorer." It also explains why it was impossible to find something commercially available that would celebrate that.
Homeless families are the fastest growing segment of the homeless population.
See more of Mary and Larry's story:


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I would only risk 1 share of AIb. Anything more and I would fell like some of these idiots smoking pipe dreams of mega$$$$$$. AIB and Ire are dogs.
Nobody give F about what Tony is doing in this world.
You guys are gonna take it on the chin. IRE and AIB are now government owned banks. Powersnow, I loan you some money boy...you are going to be broke.


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This business is not BBB accredited.
Bluemoon Bike Bazaar
Phone: (425) 678-8581 http://www.bluemoonbikebazaar.com! Bluemoon Bike Bazaar is Believed to Be Out of Business !
BBB Business Reviews may not be reproduced for sales or promotional purposes.
This company offers online sales of biking equipment and cycling gear.
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To be accredited by BBB, a business must apply for accreditation and BBB must determine that the business meets BBB accreditation standards, which include a commitment to make a good faith effort to resolve any consumer complaints. BBB Accredited Businesses must pay a fee for accreditation review/monitoring and for support of BBB services to the public.
Reason for Rating
BBB rating is based on 13 factors. Get the details about the factors considered.
Based on BBB files, this business has a BBB Rating of No Rating. The reason is as follows:
- This business has no rating because BBB has information indicating it is out of business.
Customer Complaints Summary
|Complaint Type
|Total Closed Complaints
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Definitions | BBB Complaint Process | File a Complaint against Bluemoon Bike Bazaar
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Additional Information
Type of Entity
Sole Proprietorship
Business ManagementMr. Christian Mangune, Owner
Contact Information
Business Category
Motorcycles - Supplies & Parts Auto Perform, Race & Sport Equipment


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Security Check (SC) Clearance Jobs in the North West
Jobs 1 to 15 of 22
SC Delivery Manager
My client in Cumbria has an opportunity for a Readiness Manager. This senior role sits between Programme & Build Delivery, acting as a catalyst to initiate/drive the change activities including training and communications. You will be responsible for coordinating the Improvement Activity, working with senior stakeholders and the change community...
Cumbria -
LA International
Rate: £600 per dayPosted: 15 hours ago
Senior Developer
To provide a high level of technical knowledge relating to migration of applications to modern platforms, especially understanding the existing legacy systems. To be a 'go to' person for driving forward technical aspects of migration by resolving queries from other members of the team... Experience of using VME Cobol and...
Lytham St. Annes, Lancashire -
Experis Ltd
Rate: £300.00 - £331.00 per annumPosted: 23 hours ago
Java Programmers - Public Sector Consulting opportunities
Leading global IT services and professional services consultancy seeks talented business facing Java programmers! Leveraging your expert technical Java programming skills and UML capabilities this is an opportunity not to be missed. They need people with a good technical understanding and experience in continuous integration... Using the latest tools and...
Manchester, Lancashire -
Informatiq Consulting
Salary: £40000 - £75000 per annumPosted: Yesterday
Application Tower Lead (SC Cleared ideally or eligible to take)
MAIN TASKS INCLUDE: Line Management of the 2nd and 3rd line support staff and associated line management tasks... Responsibility for the portfolio management of multiple clients including their support contracts... Project planning and control... Requirements analysis. Assist with pre-sales effort... SKILLS and experience: SC Cleared ideally or eligible to...
Cumbria -
Capita Defence & Security Resourcing
Salary: BenefitsPosted: 5 days ago
Business Process Analyst (SC Cleared or eligible)
BPMN Process / Business Analysts / Engineers - Cumbria - SC Cleared (ideally or eligible to take - Permanent... Role:- Process Engineering using BPMN v2... Production of Business Process Diagrams in Microsoft Visio 2013 using Business Process Model and Notation (BPMN) and Reference Models... Candidate:- SC cleared (or eligible to take) Certificate in Modelling Business...
Cumbria -
Capita Defence & Security Resourcing
Salary: benefitsPosted: 13 days ago
PCI QSA - Home Based - up to £80k
An award winning Cyber Security Consultancy who provide security and Assurance, Incident Response and Technology services to organisations globally are recruiting for a QSA as they looking to grow their team due to a demand and growth of business... You must be qualified as a QSA in PCI DSS, and/...
Manchester -
Computer Futures
Salary: competitivePosted: 9 days ago
Senior Business Analyst / Senior BA Barrow-in-Furness, Cumbria
Senior Business Analyst / BA / ISEB / BCS / IIBA / Business Analysis / Process Modelling / Requirements Engineering... - Leads working groups with business and technical consultants to explore business process improvement and re-engineering opportunities... The ideal candidate will be qualified to degree level in an IT related subject, or holds a certification in Business...
Barrow-In-Furness, Cumbria -
FT Select
Salary: From £50,000 to £55,000 per annumPosted: 5 days ago
Azure Architect / Azure Technical Consultant
Technologies: Microsoft Azure, Iaas - Paas, Azure AD, Azure AD Premium, System Center, Azure RMS, Storsimple, Azure Site Recovery, Intune, SQL Azure, Private Cloud, Hyper-V, Server 2012... They deliver enterprise class consulting projects across a range of Microsoft platforms including Microsoft Azure and Cloud Infrastructure... Ideally including the following: Microsoft...
Manchester -
Salary: £40k - 70k per year + amazing benefits!Posted: 12 days ago
Principal Test & Integration Engineer
We develop software using an Agile/Scrum methodology and you will be involved fully in the software development lifecycle, working closely with the developers in an integrated team environment... VMWare and Hyper-V) - Requirement verification and validation for software based systems - Test specification development - Test script preparation - Experience of scripting...
Salford, Lancashire -
Posted: 23 hours ago
Principal Cyber Engineer
In depth knowledge of virtualisation (VMWare or Hyper-V) Experience in software development in a military or Government project environment would be an advantage, but is not essential... Experience in Capture the Flag competitions Raytheon Cyber Security... All successful applicants must be eligible & willing to obtain a SC clearance with...
Salford, Lancashire -
Posted: 23 hours ago
Applications Support Lead
Internal and customer stakeholder relationship management... - Extensive knowledge displayed across a range of technical areas; - People Management - ITIL Service Management Processes - Stakeholder relationship management - Continuous Service Improvement - 3rd Party Supplier Management - Certified in ITIL V3 Foundation - Must possess extensive experience in working in different technologies - MS technology, Java, Oracle, SOA,...
Liverpool, Merseyside -
Crosby Perrin Business Solutions Ltd
Salary: From £50,000 to £55,000 per annumPosted: 13 days ago
Principal Systems Engineer
Data Modelling... Information Security Engineering and associated UK government standards... DOORS) Knowledge of Service Management under ITIL principles. Working within an Agile / SCRUM /Devops delivery model... Good time management, organisation and prioritization skills... Security: All successful applicants must be eligible & willing to obtain a SC clearance with the view to...
Salford, Lancashire -
Posted: 23 hours ago
Software Test & Integration Engineer
We develop software using an Agile/Scrum methodology and you will be involved fully in the software development lifecycle, working closely with the developers in an integrated team environment... Create and manage automated test scripts. Create and perform test manual test scripts... Experience of deploying and configuring complex software under...
Salford, Lancashire -
Posted: 23 hours ago
SQL DBA SC Cleared ideally or eligible to take
disaster recovery procedures... Installation, configuration and performance tuning of SQL Server 2000, 2005, SQL Server 2008, SQL Server 2012, SQL Server 2014. Installation, configuration and performance tuning of Oracle RDBMS versions 7-12 is beneficial. Security Clearance. MS SQL Server/Oracle Certification... Candidate:- SC Cleared (or willing to undertake) Multi-...
Cumbria -
Capita Defence & Security Resourcing
Salary: BenefitsPosted: 12 days ago
Opportunity for SIEBEL Developer_TCS
Role: SIEBEL Developer... - Demonstrate hands-on experience in Siebel EAI Technologies HTTP, FTP, XML Transports, Web Services and Integration workflow Processes... - Demonstrate experience in Siebel BI Publisher reports... - Siebel 8.x Certified... - Demonstrate experience with Software development lifecycle methodologies, quality assurance and software testing, business requirement definition, systems analysis and...
Liverpool,United Kingdom -
Tata Consultancy services
Rate: £0 per yearPosted: 19 days ago
SC Cleared Jobs in the North West


text:
Fourth of July Hours: 9AM - 9PM; Closing early for inventory Sunday, July 10: 9AM - 6PM
603 N. Lamar Blvd Austin, TX 78703 512-472-5050 Open 9AM - 11PM The largest independent bookstore in Texas!
Books On Our Site May Not Be Available In-Store
Is This Book In Stock? Be Savvy! Check availability details beneath the blue "Add to Cart" button.
Awardwinner and USA Today bestselling author Rachel Gibson's smart, sassy contemporary romances are making her one of the genre's fastest rising stars.


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Written on: 22/01/2009
Bad Points
General Comments
Just amazing. Have used it for years and gets most stains out with a pre soak. However all my local supermarkets hace stopped supplying it. help i live i woodstock oxford ox20
As rated by our community of reviewers
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Studiocanal Miramax Titles (UK - BD RB)
Studiocanal will soon release some of Miramax's classic features on Blu-ray...
Starring: Various
Released: 19th September 2011
Further Details:
Studiocanal has announced the Blu-ray release of a number of Miramax titles for the 19th of September, priced at around £24.99 apiece. The available titles will include The Aviator, City of God, Emma, The English Patient, The Quiet American and The Talented Mr. Ripley. Details for all titles can be found below, along with the artwork.
The Aviator
- 2.35:1 Widescreen Transfer (1080p AVC)
- DTS-HD Master Audio 5.1
- Filmmaker Commentary
- Deleted Scene: Howard Tells Ava About His CarAccident
- A Life Without Limits: The Making Of The Aviator
- The Role of Howard Hughes, A History Channel Documentary
- The Affliction of Howard Hughes: Obsessive Compulsive Disorder
- OCD Panel Discussion With Leonardo DiCaprio, Martin Scorsese and Howard Hughes' Widow, Terry Moore
- Constructing The Aviator: The Work of Dante Ferretti
- Costuming The Aviator: The Work of Sandy Powell
- The Age of Glamour: The Hair and Makeup Of The Aviator
- Scoring The Aviator: The Work of Howard Shore
- The Wainwright Family – Loudon, Rufus and Martha
City of God
- 1.85:1 Widescreen Transfer (1080p AVC)
- DTS-HD Master Audio 5.1
- News from a Personal War
- A Conversation with Fernando Meirelles
- 1.85:1 Widescreen Transfer (1080p AVC)
- LPCM 2.0 Audio
- Trailer
The English Patient
- 2.35:1 Widescreen Transfer (1080p AVC)
- DTS-HD Master Audio 5.1
- Commentary with Director
- Commentary with Director, Producer, Author
- About Michael Ondaatje
- From Novel to Screenplay
- The Formidable Saul Zaentz
- Historical Look at the Real Count Almasy
- A Conversation with Anthony Minghella
- A Conversation with Saul Zaentz
- A Conversation with Michael Ondaatje
- A Conversation with Walter Murch
The Quiet American
- 2.35:1 Widescreen Transfer (1080p AVC)
- DTS-HD Master Audio 5.1
- Anatomy of a Scene
- Feature Commentary
- Original Featurette
- Interviews
- B-Rolls
The Talented Mr. Ripley
- 1.85:1 Widescreen Transfer (1080p AVC)
- DTS-HD Master Audio 5.1
- Audio Commentary with Director Anthony Minghella
- Teaser Trailer
- Full Length Trailer
- Cast and Crew Interviews
- Inside The Talented Mr. Ripley
- Making of the Soundtrack
News by Chris Gould
Follow our updates
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24: Season One AU - DVD R4 Max Payne UK - DVD R2 Who Dares Wins UK - BD RB Lisa and the Devil UK - BD RB Predestination US - BD RA
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By Brian Perry
When constructing a portfolio, the primary consideration is to build the portfolio that is most likely to help an investor achieve his or her financial goals. This optimal portfolio can vary greatly depending on an investor's unique return objectives and risk tolerance. This chapter will discuss how an emphasis on safety and income can be integrated into the portfolio process to help an investor build an optimal portfolio.
Return Objectives
When building an investment portfolio, an investor must determine what it is that they are trying to accomplish. For an individual, this can be any one of many things. An individual may be investing to build a retirement portfolio, to purchase a new home or to build a rainy day fund. These objectives will carry with them different time horizons, which means that the optimal portfolio in each instance is quite different. When the time horizon is very long, such as for some retirement investment programs, a portfolio can be invested in a more aggressive manner. When the time horizon is short or the funds are intended to serve as an emergency backstop, an emphasis on safety becomes more important.
In addition to capital appreciation, a goal of an investment program may be to generate income to meet expenses. This is particularly true for individuals who are retired or who depend on their portfolios for ongoing income. For these individuals, income becomes an important consideration when structuring a portfolio.
Risk Tolerance
Perhaps the most important question an individual needs to ask when constructing an investment portfolio is: "what is my risk tolerance?" The combination of return objectives and risk tolerance will then determine the optimal portfolio and the optimal asset allocation. Again, time horizon plays an important role in determining risk tolerance. The longer the time horizon, the more risk an investor is able to take. The shorter the time horizon, the more cautious an individual should be in his or her investment approach.
The above discussion focuses on the ability to take risk, but there is another important consideration in determining risk tolerance. In addition to ability to take risk, investors should also carefully consider their willingness to take risk. These two factors are not always in alignment. For instance, an investor with a long-term goal may have the ability to take on additional portfolio risk, but if the thought of losing money keeps them awake at night they might not have the willingness to take much risk.
Safety, Income and Growth
Safety, income and growth are the three main objectives within an investment portfolio. The degree of emphasis placed on each of these goals will differ depending on an individual investor's return objectives and risk tolerance. Cautious investors will emphasize safety, while aggressive investors will emphasize growth. Likewise, investors who require cash flows from the portfolio will emphasize income while with no need for income will emphasize growth.
While the degree of emphasis on these three objectives will vary, under most circumstances investors should not exclude one. For instance, even in the most cautious of investment programs, attention should be paid to growing the portfolio enough to keep pace with the rate of inflation. Likewise, even aggressive investors with long-term time horizons should pay strict attention to risk management, as large losses in a portfolio can be difficult to overcome even over long time periods. Finally, regardless of whether an individual intends to withdraw cash from the account, income is responsible for a large portion of total return in investment portfolios over time; therefore, investors that ignore this crucial component do so to their own detriment.
In general, younger investors will have a reduced emphasis on safety and income while older investors will focus more closely on these goals. Likewise, individuals with short-term time horizons will primarily focus on safety while those with longer-term objectives will be interested in growing the portfolio. Importantly though, investors should seek to balance both safety and growth within the portfolio management process; the precise emphasis will vary depending on unique circumstances, but neither should be ignored. Finally, regardless of whether withdrawals are intended from the portfolio, income can help to produce superior total return in a portfolio over time.
Managing Wealth
Achieving Optimal Asset AllocationMinimizing risk while maximizing return is any investor's prime goal. The right mix of securities is the key to achieving your optimal asset allocation.
Financial Advisor
Risk Tolerance Only Tells Half The StoryJust because you're willing to accept a risk, doesn't mean you always should.
Managing Wealth
The Workings Of Equity Portfolio ManagementAchieve analytical efficiency by applying your evaluation to a key set of stocks.
Matching Investing Risk Tolerance To PersonalityUnderstanding risk tolerance is crucial to the advisor/client relationship and any good investment policy statement.
How To Create An Effective Retirement Income StrategyWe will design a portfolio that should balance the requirements of liberal income with sufficient liquidity to withstand down markets.
What Does an Ideal Retirement Portfolio Look Like?The "ideal" portfolio can differ from one investor to another depending on many factors, but some themes hold true no matter what.
5 Popular Portfolio TypesLearning how to build these portfolios will increase your investing confidence and give you financial control.
What Is Your Risk Tolerance?Forget the cliches and uncover how much volatility you can really stand.
Managing Wealth
Understanding Portfolio InvestmentPortfolio investment involves buying securities with the expectation of earning a return on them.
Financial Advisor
How to Help Clients See Value of DiversificationOne of an advisor's most important jobs is getting clients to understand the value of diversification. Here are some tips that will help.


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bisous ciao
235 Bleecker St.,
New York, NY 10014
Official Website
Mon-Thu, 8:30am-10pm; Fri-Sat, 8:30am-11pm; Sun, 10am-10pm
Nearby Subway Stops
A, B, C, D, E, F, M at W. 4th St.-Washington Sq.; 1 at Christopher St.-Sheridan Sq.
Payment Methods
American Express, Discover, MasterCard, Visa
While Tanya Ngangan was studying fashion design in Paris, she developed a taste for more than Chloé and Chanelshe also fell in love with authentic Parisian pastries. Back in New York, she worked for Gordon Ramsay before opening this authentic French macaroon boutique with her partner, French businessman Alex Warzee. Tanya had a specific vision: The store would be a sophisticated showcase for her traditional baked-from-scratch almond and egg white morsels. The sleek black-and-white space doesn't have chairs or tables, but there is plenty of space for loitering (much like a French grab-and-go patisserie). The absence of clutter means that nothing competes with her delicately decorated, brightly hued creations. Echoing the chef's background in fashion, the collection is composed of Classics and a rotating range of seasonal offerings. The Fleur, collection, for example, includes violet, rose, poppy, jasmine, and green tea cookies, while Fall/Winter heralds options like chestnut and salted peanut butter and jelly. Base ingredients are locally sourced, but specialty additions are culled from across the globe: fresh vanilla from Tahiti, rosewater from Iran, ground pistachios from Italy, sea salt from Brittany, and of course French dark chocolate.
- Amnesty International Says Mexican Authorities Are Using Physical and Sexual Torture to Force Confessions from Women
- Leah Remini Is Apparently Filming Footage for a Show About How Scientology Tears Families Apart
- Lil' Kim Has a Lot of Love for Brooklyn and That Means She Has a Lot of Love for Desiigner
- On Game of Thrones, Crop Tops Are the Ultimate Sign of Freedom


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Insect eggs? Fungus?
What is on my hickory leaves?
Resin Northumberland, United Kingdom(Zone 9a) Jun 26, 2013
The round yellow things are galls; the folded-over and browned leaf edge might be woolly aphids (unroll it and see if there's bits of white waxy fluff and really tiny insects inside)
passiflora_pink Central, AL(Zone 8a) Jun 27, 2013
Thanks Resin! Again!
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I'm building a simple menu and came up with a doubt: the user is gonna have some defined commands, for example, an entry would be "compact image < filename >.jpeg". How can I get the filename and extension from the middle of the string?
If that is an actual example of the string that you need to get the file name from you can:
Use strstr to find instances of "needle" in "haystack" - it will return an index to the ".", for example, and you can construct new strings containing the file-name and extension using this index.
Hope this helps!


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Fort Bend County shooting that left three dead started with...
61 arrests made in biggest-ever sex trafficking bust for...
Downtown deli Delivery Market closes
Red Cross apologizes for, stops production of 'super racist'...
Airman who killed self in Target parking lot was 39
Ex-student gets life term for killing baby at sorority house
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UTSA loses its third recruit in a week; Neph to Oklahoma State
SAN ANTONIO — UTSA's football signing class has taken the third hit in a week with the defection of receiver John Cole Neph from Owasso, Okla. Owasso head coach Bill Patterson said in a telephone …
Galena Park cornerback to sign with Fresno State
SAN ANTONIO — Galena Park's Anthoula Kelly switched his commitment from UTSA to Fresno State over the weekend, Galena Park coach Dave Handal said Monday. Kelly, a speedster who had played multiple …
UTEP men win fourth straight with 81-62 victory over UTSA
Allegations of gambling rocked the UTEP men's basketball team a few weeks ago, leading to the suspension of three players, including the Miners' leading scorer. If the Miners have been distracted by …
UTSA loses Longview defensive back to Big 12's TCU
SAN ANTONIO — Longview safety and punt return specialist Travin Howard has committed to TCU, Longview coach John King said Friday afternoon. Howard had been committed to UTSA since mid-December. King …
Gresham says he is 'extremely intrigued' about UTSA opportunity
Fort Worth-based running back Daniel Gresham says he is "extremely intrigued" about the possibility of playing for the UTSA Roadrunners. Recruited by some of the top programs in the nation out of Fort Worth All Saints Episcopal, Gresham will be in San Antonio on his official visit to UTSA through Friday. …
Coveted running back 'having a good time' on UTSA visit
SAN ANTONIO — A running back who once held offers from Alabama, Texas, Ole Miss and Florida State — one who recently dropped off the recruiting board at Louisville — made an official visit to UTSA …
Middle Tennessee downs UTSA 60-41 in women's basketball
Forward Ebony Rowe produced 26 points and 16 rebounds Wednesday night as the Middle Tennessee Blue Raiders downed the UTSA Roadrunners 60-41 in Conference USA women's basketball. In the game played at …
After meeting with Coker, Anzaldua remains committed to UTSA
Edinburg North offensive tackle David Anzaldua met with UTSA coach Larry Coker Tuesday night in Edinburg. Anzaldua said he intends to sign with the Roadrunners on Feb. 5. …
UTSA women are winning again in cross country, distance events
The UTSA women's cross country team won a Conference USA title last fall. Now, Alyssa Diaz and her friends on the women's track team seem poised to reclaim some of the program's pride in the distance running events. …
Former UTSA quarterback enrolls at Stephen F. Austin
UTSA has reeled in its 11th commitment in the 2014 football recruiting class. Florida-based linebacker Justin Todd will sign with UTSA, the player's high school coach confirmed. Todd is UTSA's third commitment from out of state. …


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Henderson Jobs
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Henderson, MI Job Openings
CRST ExpeditedHenderson, MI, 48841
Henderson, MI
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this registered thoroughbred mare is 12 years old and 15 hands tall. very sweet, has been my daughters horse (she is now 9) for the past 3 years.very gentle…SOLD
By an Awesome Again stud--Everyday Heroes o/o a Kissin Kris mare. Flashy, good conformation.SOLD
5 year old mare by Avenue of Flags. Ride, Race or Breed this beautiful dark bay mare. She could be a polo, barrel, dressage, race, trail or companion…SOLD
5 year old thoroughbred gelding by Avenue of Flags. He is strikingly beautiful and has an enormous stride. He is ready to hit the New Mexico Racetrack…SOLD
Open Mare by Bertrando out of a Fappiano Dam. This girl is big and correct in every way. She has 3 to race with 3 winners and a yearling by Weather Warning…SOLD
PRICE REDUCED!! Cuvex is out of Cuvee and Exbourne Free. He has been started on barrels, but could go any direction. He is an alpha horse but loves his…SOLD
Beautiful NM Bred Thoroughbred for sale. He is a big, athletic horse that will make a good dressage, hunter jumper,polo or barrel prospect. He is very…SOLD
Razzi Flag.. 3 year old filly that showed tremendous speed and athleticism. Sire is Avenue of Flags and broodmare sire is Bertrando. Will make a tremendous…SOLD


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Product Positions1Close Date9/30/2016LocationNew York City Outbrain is the world's leading content discovery platform, empowering marketers to distribute their content on the web's largest and most respected media properties, such as CNN, People and ESPN. We?re hiring a5/9/2016 New York, NY Save This Job
Job Description As Product Manager, you will work with a team that is charged with increasing the success of the companys main product. In this role, you will champion all activities related to the definition, development and lifecycle of Silvons Stratum product line. This5/9/2016 Chicago, IL Save This Job
Sunnyvale, CA Labcyte Inc. is the leader in low-volume liquid handling for the life sciences. We use acoustic droplet ejection technologies to provide highly accurate, fully automated, non-contact dispensing down to 2.5 nanoliters. This green technology provides significantly5/7/2016 Sunnyvale, CA Save This Job
Full-Time ? San Francisco Slack is looking for an experienced Product Manager to guide the design, development, and support of features to allow teams to discover and make use of integrations on Slack. Do you get excited about working on Platforms and want to help users find5/7/2016 San Francisco, CA Save This Job
Sunnyvale, CA Labcyte Inc. is the leader in low-volume liquid handling for the life sciences. We use acoustic droplet ejection technologies to provide highly accurate, fully automated, non-contact dispensing down to 2.5 nanoliters. This green technology provides significantly5/7/2016 Sunnyvale, CA Save This Job
Location: Burlington, MA Product Manager Intern - Fall 2016 (September - December) The Product Manager Intern will work closely with Product Managers in product planning and execution throughout the product lifecycle, including: gathering and prioritizing product and customer5/3/2016 Burlington, MA Save This Job
Engineering San Mateo, CA We are looking for an experienced product manager with a technical background to own parts of our enterprise SaaS platform. You will be working closely with an all star team of product managers, engineers, data scientists and designers to implement5/3/2016 San Mateo, CA Save This Job
Product, New York, Full-time Do you want to revolutionize the way people learn online? Codecademy is looking for a top notch Product Manager to drive vision and execution for our online learning platform. The ideal candidate thrives on balancing product strategy and execution,5/2/2016 New York, NY Save This Job
Product Management San Francisco, CA Job Description Want to join a company on the cutting edge of technology and travel? Want to be part of a fantastic and fun company that?s revolutionizing the online travel advertising space? Sojern is travel's leading data-driven5/2/2016 San Francisco, CA Save This Job
Location: Seattle, WA Product Manager: (Seattle, WA) Responsible for utilizing metrics-driven decision making to plan and oversee a mobile application game, taking it through the entire product lifecycle from conception to live operations for play. Duties include the4/27/2016 Seattle, WA Save This Job
at Weebly San Francisco Weebly enables entrepreneurs to create a site, blog, or online store they are proud to share. We have a nimble, efficient team that is focused on building a surprisingly easy product experience to meet the needs of millions around the world. As a4/26/2016 San Francisco, CA Save This Job
Danaher Company Description Arbor Networks is a leading provider of network security and monitoring solutions for global networks. Its customers include 90 percent of the world?s ISPs and large enterprises. Arbor solutions deliver best-in-class network security and visibility,4/20/2016 Ann Arbor, MI Save This Job
Product Management Seattle, Washington Apply Description Do you have a passion for building easy-to-use, innovative products for engineering teams? Do you thrive in an environment where you wear many hats, do what it takes, work hard and smart, collaborate, innovate, and6/29/2016 Seattle, WA Save This Job
We are looking for a talented Senior Product Manager (Learning) who is excited about working in a rapidly growing technology company and who will thrive in a fun and challenging environment. The right person will be responsible for managing our learning product throughout the6/27/2016 San Francisco, CA Save This Job
Job Tracking ID: 512170-535781 Job Location: Fremont, CA Job Level: Mid Career (2+ years) Level of Education: BA/BS Job Type: Full-Time/Regular Date Updated: May 26, 2016 Years of Experience: 5 - 7 Years Starting Date: ASAP Job Type: Exempt Invite a friend facebook LinkedIn6/20/2016 Fremont, CA Save This Job
Product Marketing and Management Redwood City, CA, United StatesApply Now Send Jobvite Application Security ? Senior Product Manager - Redwood Shores, CA?? Our Company?Imperva (NYSE: IMPV), is a leading provider of cyber security solutions that protect business-critical data6/15/2016 Redwood City, CA Save This Job
Product ManagerTechnologyColumbia, MDType: Full TimeMin. Experience: Mid Level Lotame provides comprehensive data management capabilities helping digital Publishers, Marketers and Advertisers collect, organize and activate their audience data. Lotame?s Product and Technology6/9/2016 Columbia, MD Save This Job
Reporting to the Product Director, the (Sr.) Product Manager must be a passionate, proven product leader who understands the importance of collaboration and can distill highly complex issues into easy to understand requirements. This person will be responsible for the planning5/31/2016 Menlo Park, CA Save This Job
A Little About Crowdtap: Crowdtap is a fast-growing, profitable, VC-backed startup that has been named one of America's 100 Most Promising Companies in Forbes in 2013 & 2014. Our platform makes it easy for Fortune 500 brands to inspire consumers to create authentic content,5/29/2016 New York, NY Save This Job
Madison, WIFull-time Company Description We develop and manufacture fully functioning human cells in industrial quantities to precise specifications. Our proprietary iCell Operating System (iCell O/S) includes true human cells in multiple cell types (iCell products), human5/25/2016 Madison, WI Save This Job


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Five-Vegetable Curry
From EatingWell: March 1998, March/April 1995
Eggplant, potatoes, sweet potatoes, tomatoes and green beans flavored with rich Indian spices yields a substantial dish. Make it a meal: Top with plain nonfat yogurt and serve with brown basmati rice.
Makes: 4 servings
Active Time:
Total Time:
Nutrition Profile
Diabetes appropriate | Low calorie | Low cholesterol | Low saturated fat | Heart healthy | Healthy weight | High fiber | High potassium | Gluten free |View Our Nutrition Guidelines »
- 1 tablespoon canola oil
- 3 cloves garlic, finely chopped (1 tablespoon)
- 1 tablespoon grated fresh ginger
- 1 jalapeño pepper, seeded and finely chopped
- 1 teaspoon ground cumin
- 1/4 teaspoon ground turmeric
- 2 teaspoons sugar
- 1 teaspoon salt
- 1 cup water
- 1 1-pound eggplant, unpeeled, cut into 1-inch cubes
- 12 ounces potatoes, preferably Yukon Gold, peeled and cut into 1-inch cubes (3-4 potatoes)
- 12 ounces sweet potatoes, peeled and cut into 1-inch cubes (2-3 sweet potatoes)
- 8 ounces tomatoes, preferably plum tomatoes, seeded and coarsely chopped
- 4 ounces green beans, cut into 2-inch pieces
- 1-2 tablespoons chopped blanched almonds, ground to a coarse powder
- 2 teaspoons garam masala, or curry powder (see Note)
- Heat oil in a large high-sided skillet or Dutch oven over medium heat until very hot. Add garlic and ginger and cook until golden, about 1 minute. Add jalapeño, cumin and turmeric and stir to distribute evenly.
- Add sugar, salt and water. Increase heat to high and bring to a boil. Add eggplant, potatoes, sweet potatoes and tomatoes. Reduce heat and simmer, covered, stirring occasionally, 15 to 20 minutes. Add green beans and simmer, covered, until the vegetables are tender, 15 to 18 minutes more.
- Mash a few of the potatoes and sweet potatoes with the back of a spoon and mix into the sauce. Stir in almonds and garam masala (or curry powder). Remove from the heat. Let stand 10 minutes before serving to allow flavors to develop.
Tips & Notes
- Note: Garam masala is a blend of spices used in Indian cooking, usually including cardamom, black pepper, cloves, nutmeg, fennel, cumin and coriander. Garam masala is available in the spice section of most supermarkets.
Per serving: 230 calories; 5 g fat (0 g sat, 3 g mono); 0 mg cholesterol; 43 g carbohydrates; 5 g protein; 9 g fiber; 638 mg sodium; 1014 mg potassium.
Nutrition Bonus: Vitamin A (89% daily value), Vitamin C (56% dv), Potassium (29% dv).
Carbohydrate Servings: 2
Exchanges: 2 starch, 1 vegetable, 1 fat
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Recipe Categories
- Type of Dish
- Main dish, vegetarian
- Health & Diet Considerations
- Diabetes appropriate
- Low calorie
- Low cholesterol
- Low saturated fat
- Heart healthy
- Healthy weight
- High fiber
- High potassium
- Gluten free
- Ease of Preparation
- Easy
- Total Time
- 1 hour or less
- Servings
- 4
- Preparation/ Technique
- Braise/Stew
- Saute
- Meal/Course
- Dinner
- Style/Theme
- Everyday favorites
- Vegan
- Vegetarian
- Publication
- March/April 1995
- March 1998


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Mullet Haul
Date & Time
Saturday, March 10, 2012 (All day)
Mullet Hall Equestrian Center
Event Details
Sport a real or artificial "business in the front, party in the back" hairstyle for this annual competition. Runners choose either a five- or 10-mile course through the trails of Mullet Hall. Afterward, watch the awards ceremony and enjoy live music at the post-race party. Mullet Hall Equestrian Center, 2662 Mullet Hall Rd., John's Island. Saturday, 10am-2pm. Five mile: $34; $28 Charleston County resident; 10-mile: $44; $36 Charleston County resident. (843)795-4386, www.ccprc.com
Upcoming Events
Thursday, July 14, 2016 - 6:00pm
Saturday, July 16, 2016 - 10:00am
Monday, July 4, 2016 -
5:30pm to 9:30pm