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Forum indexCanon EOS 7D / 10D - 80D TalkChange forum
Canon 7d pictures flat?
Started Mar 27, 2013 | Discussions thread
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(unknown member) • Senior Member • Posts: 2,853
Re: Canon 7d pictures flat?
In reply to BAK • Mar 27, 2013
BAK wrote:
The first shot is so badly exposed that it is hopeless.
If maintaining highlight detail in the flower itself is the point I don't think it is a horrible exposure, although I don't really get the settings used. Drop the ISO and shutter speed?
The second shot "snaps up" nicely with thirty seconds of levels adjustment.
"Snap", "pop", or even "crackle" are a matter of internal settings OR good editing. If these two were shot in the RAW the first one should be pretty easily adjusted within reason and the second one will pop like a firecracker if you want it to.
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How Some Celebs Turn The Oscars Into A Huge Pay Day, While Others Can't
Try as we might to convince ourselves that celebs are just like us (David Beckham tweets! Katie Holmes wears Kohl's!), we all know that nothing is as it seems in Lala Land. And, with the Oscars just days away, the secret lives of the rich and famous are coming to light — and it's not just Jennifer Lawrence who gets special treatment.
In 2011, it seems Tiffany & Co. dropped a whopping $750,000 on Anne Hathaway just so she'd wear the company's gems with her Valentino gown. And get this: That same year, Louis Vuitton shelled out $500,000 when Gwyneth Paltrow wore the brand's jewels on stage. Of course, the news of celebs being paid to parade around in gorgeous get-ups isn't breaking news, but what's somewhat heartbreaking is that the actress with less audience appeal (a.k.a. not so young and thin) won't have the same opportunities as these ideal A-listers, oftentimes giving the dressmaker or jewelry designer they've chosen free publicity. So, as the sample-sized gals get lofty checks at evening's end, most women on that carpet won't be considering Sunday a pay day at all.
It's a sad truth in Tinseltown, but no matter what, good taste conquers all — and that means everyone has a fair shake at the best-dressed list. (Huff Post Style)
Photo: Via Huff Post Style
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Dinamo Moscow suffered their first defeat of the Stanislav Cherchesov era as they were beaten 2-1 at home by Krasnodar.
Cherchesov's reign got off to an ideal start last week as his new side put five past Volga without reply, but his honeymoon period would appear to be over after Dinamo lost further ground on the top three.
Aleksandr Kokorin gave Dinamo the lead at Arena Khimki with a goal just before the half-hour mark.
However, Aleksey Kozlov was then dismissed after the interval and Roman Shirokov and Ricardo Laborde took advantage with goals for Krasnodar, with the former then seeing red late on.
The result represents another blow to Dinamo's slim hopes of qualifying for the UEFA Champions League as the division's leading trio all picked up wins.
Zenit continued their revival under Andre Villas-Boas with a fifth win in a row under the Portuguese.
Goals from Salomon Rondon and Danny were enough to see off rock-bottom Anzhi 2-1.
Lokomotiv Moscow remain a point behind leaders Zenit after edging past Terek Grozny 2-1 thanks to a late brace from Roman Pavlyuchenko.
Third-placed CSKA Moscow were convincing 4-0 winners at 10-man Kuban Krasnodar.
Steven Zuber, Seydou Doumbia, Konstantin Bazelyuk and Zoran Tosic were on target to see off a Kuban side that had Roman Bugaev sent off towards the end of the first half.
Spartak Moscow's hopes of clinching a European place were damaged by a dramatic 2-1 defeat at Rubin Kazan.
Alexander Prudnikov struck in the last minute for mid-table Rubin, meaning Spartak are only one point above Krasnodar, who sit sixth.
At the foot of the table, Anzhi were cut further adrift due to victories for Volga and Tom' Tomsk over Rostov and Krylya Sovetov respectively.
Volga were 2-1 winners, while efforts from Renat Sabitov and Jan Holenda handed Tomsk a 2-0 triumph.
Just six points separate Volga in 15th and Ural in 11th, the latter moving out of the relegation play-off spots thanks to a 2-0 away win at Amkar Perm' in which Edgar Manucharyan and Vladimir Khozin were on target.
A. Kokorin 27'
(assist by A. Kasaev)
1 - 0
1 - 1
73' R. Shirokov
(assist by Joãozinho)
1 - 2
81' R. Laborde
(assist by M. Pereyra)
|V. Gabulov
|C. Samba
|V. Granat
|A. Kozlov
|I. Denisov
|C. Noboa
|A. Kasaev
|A. Yusupov
|K. Kuranyi
|A. Kokorin
|Coach: S. Cherchesov
|A. Sinitsyn
|A. Granqvist
|R. Sigurðsson
|V. Kaleshin
|A. Jędrzejczyk
|R. Shirokov
|73' 90+2'
|Y. Gazinskiy
|S. Petrov
|Coach: O. Kononov
for A. Kasaev 64'
for A. Yusupov 76'
for K. Kuranyi 87'
for Ari 59'
|81' 89'
for S. Petrov 59'
for Y. Gazinskiy 86'
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Relevant offers
Christchurch has the honour of being the world's second-best place to visit in 2014, according to the New York Times.
As part of its "52 places to visit in 2014" the The Times called Christchurch a "city in transformation" that was experiencing a "rebirth with creativity and wit".
Thanks to the ingenuity of its "hardy residents" Christchurch was welcoming tourists back again, the influential news organisation said.
Cape Town in South Africa was top of the list with the north coast of California, the Albanian coast and downtown Los Angeles rounding out the top five of 52 places in the world.
The newspaper praised Christchurch entrepreneurs and volunteers that were finding ways of using empty lots to bring life back to the central city - particularly Gap Filler and the Greening the Rubble campaign.
It also cited the transitional cathedral by Japanese architect Shigeru Ban as an example of the city's slow renaissance.
It said businesses were "trickling" back into the city and one bar encapsulated the spirit of the entire city with its name: Revival.
- The Press
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*Lil Wayne is recovering this morning after an in-flight medical scare on Thursday afternoon that forced the rapper's plane to make an emergency landing in Texas.
After Weezy had suffered from seizure-like symptoms on a private jet, the craft landed in an undisclosed location in Texas, according to TMZ. From there, he was rushed to a local hospital and treated for several hours before being released around 6 p.m. local time.
A rep for the Young Money leader had no comment about the incident. At press time, further information about his condition was not released and it's unclear what the rapper was being treated for. However, sources close to the MC tell TMZ that he is now "doing better."
Lil Wayne is currently prepping the release of his 10th solo album "I Am Not a Human Being II," which is set for release in December. He's worked on track with Kanye West, and nearly 100 tracks with legendary rapper, producer and mogul Dr. Dre.
"I've always worked with Dre," Wayne told MTV in Las Vegas last week. "I'm not sure if you guys know how Dre works. Dre always send you a song, so I done probably did like 90 songs for Dre. You just never know which one he gonna put out."
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Baltic States – CIS, Energy, Estonia, Lithuania, Nuclear Power
International Internet Magazine. Baltic States news & analytics
Thursday, 30.06.2016, 06:07
Lithuania urges Belarus to comply with nuclear safety regulations
Espoo Convention Implementation Committee had issued its findings on April 15 and stated that Belarus had violated the Convention, had not submitted nuclear power plant project's environmental impact assessment information to Lithuania. The Committee also determined that Lithuania's questions regarding construction site choice, seismic research and impact on Lithuanian citizens, underground waters and Neris River were justified, reported LETA.
Espoo Convention Implementation Committee urged Belarus to provide answers to all Lithuania's questions, take into consideration Lithuanian experts' observations and implement all other Espoo Convention obligations.
On August 17 in Belarusian town of Astravyets a meeting was organized which was presented as informing Lithuanian public about the nuclear power plant construction.
However, the Lithuanian MFA points out that Lithuania was not provided with environmental impact assessment documentation of Belarusian nuclear power plant which would meet Espoo Convention requirements. Furthermore, by inviting Lithuanian public to Astravyets, Belarus ignored environmental impact assessment introduction stage, said the Ministry of Foreign Affairs.
In addition, the MFA notes that the decision by Belarus to hold an event for Lithuanian public in the territory of Belarus had restricted Lithuanian citizens' rights to access information about the nuclear power plant project.
The United Nations Convention on Environmental Impact Assessment in a Transboundary Context (Espoo Convention) is the primary international document providing the necessity for neighboring countries to cooperate regarding nuclear power plant construction issues.
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The Insider
Jackson's people, by the way, are in final negotiations with HBO for the singer to perform a cable-TV concert, tentatively scheduled for Dec. 10. Sources say the site of the concert—and whether it will be broadcast live—is still to be determined. A spokeswoman for HBO said she was unaware of any arrangement with Jackson....
Will Roseanne's byline appear in the September debut issue of John F. Kennedy Jr.'s new political magazine, George? The television star says editors there asked her to write a 600-word piece to be called "If I Were President." According to Roseanne, she did, but she has yet to see an edited version of her essay. Nonetheless she says she was "flattered" to have been asked and that she "really enjoyed writing it." Spokesmen for George, however, were far less enthusiastic. In fact they went so far as to deny having any dealings with Roseanne....
Composer Andrew Lloyd Webber has supplied original music for a forthcoming British Airways commercial....
The results of recent amniocentesis indicate that talk show host Marilu Henner, 43, and her husband, producer-director Robert Lieberman, are expecting a boy. His name will be Joseph and he's due in November. Henner said that on the set in Toronto, where she is shooting the upcoming NBC movie Fight for Justice: The Nancy Conn Story, about one of the founders of the victims' rights movement, there's a "Joey watch." The phrase, Henner said, refers to the monitoring of her expanding profile throughout production. The character she plays in the film isn't pregnant, so when Henner begins to show, it's time to change camera angles. The Liebermans have another son, Nicholas, 1....
All work and no play isn't a good idea for anyone, even the prosecutors on the O.J. Simpson case. So Christopher Darden accompanied Marcia Clark and her two small sons to the June 24 matinee of the L.A. stage production of Beauty and the Beast. Darden, Clark and the children seemed to enjoy the show, as did my source, who happened to be seated three rows behind them at the Schubert Theater....
Singer-songwriter Bob Dylan came this close to playing a Bible salesman in Feeling Minnesota, a forthcoming dark comedy starring Keanu Reeves and Vincent D'Onofrio as feuding brothers. According to a rep for the film's distributor, Fine Line Features, Dylan fell out of the project over scheduling problems. He is currently on the road, touring in Europe. The film went on without him, and the small role wound up going to another veteran rocker, Levon Helm, the drummer of the Band. Helm is no stranger to acting; his credits include films such as Coal Miner's Daughter (1980) and The Right Stuff (1983).
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Home > News > Intel moves up debut of billion-transistor chip
July 15th, 2004
Intel moves up debut of billion-transistor chip
Not only does Intel Corp., the world's largest chipmaker, believe Moore's Law is alive and well, it is aiming to deliver a billion-transistor chip in 2005, rather than the original target date of 2007. The accelerated introduction of the billion-transistor integrated circuit was discussed by Jai Hakhu, vice president of Intel's Technology Manufacturing Group, during a conference organized by Merrill Lynch at the annual Semicon West exhibition here on Wednesday (July 14).
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List all words ending with colotomy
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WOMEN'S SOCCER: Utah Valley's Nicole Archibald Spencer and Lauren Sack have been honored by the Great West Conference for their performances in a 3-0 week for the Wolverines. Archibald Spencer shared Offensive Player of the Week with South Carolina State's Brooke Ehinger, while Sack was named the Defensive Player of the Week, the conference office announced Monday.
Spencer, a senior from Smithfield, Utah, helped Utah Valley knock off three teams last week — two conference teams — while notching two goals and two assists for six points for the week. The forward scored a goal and an assist in a 3-0 win over North Dakota State then tallied the game-winning goal in a 1-0 win over North Dakota to help the Wolverines clinch the GWC West Division. Spencer leads the team with eight goals in 2010.
Sack earned defensive player of the week with three consecutive shutouts (two solo, one team shutout) last week. The goalkeeper from Reno, Nev., recorded 12 saves total on the week and lowered her goals-against-average to 0.25 in Great West Conference play. The freshman also posted an assist on the game-winning goal against North Dakota.
MEN'S GOLF: After Monday's first two rounds of the Bill Cullum Invitational at Wood Ranch Golf Club on Monday in Simi Valley, Calif., the Utah Valley University men's golf team currently sits in 13th place heading into today's final round.
UVU's Joey Olson fired a first-round, ever-par 72 and followed it up with a 76 in the afternoon round for a 148 total that was good enough for 28th place, while Andrew Carlin, who shot rounds of 75 and 76, is tied for 42nd place at 151.
Nick Tarasiewicz (78-77) and Parker Redding (80-75) are tied for 64th at 155, while Stratton Schulz (79-77) is tied for 69th at 156.
The Wolverines are nine shots out of ninth place and 15 shots out of eighth.
The University of Portland, led by Jake Wagner (70-71), who is tied for second, leads the tournament with a 581, while San Jose State (582) and UC Riverside (584) are second and third, respectively.
CS San Bernardino's Kenny Pigman shot a 5-under 67 in the first round and followed up with an even-par 72 to lead the tournament by two shots at five-under 139.
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|By Marketwired .
Article Rating:
|January 24, 2013 02:58 PM EST
TIMBERVILLE, VA -- (Marketwire) -- 01/24/13 -- F & M Bank Corp. (OTCQB: FMBM), parent company of Farmers & Merchants Bank, announces its financial results for the fourth quarter and year ending December 31, 2012 and its recently declared fourth quarter dividend.
Year to date net income for 2012 totaled $4.901 million, an increase of 4.54% over 2011 earnings which totaled $4.688 million. Net income for the fourth quarter of 2012 totaled $1.244 million, compared to $1.433 million of earnings for the same period in 2011.
Selected Financial Highlights: 2012 YTD 2011 YTD 2012 Q4 2011 Q4 -------- -------- -------- -------- Net Income (000's) $ 4,901 $ 4,688 $ 1,244 $ 1,433 Earnings per share 1.96 1.91 0.49 0.57 Net Interest Margin 3.95% 3.87% 4.03% 3.98% Allowance for loan losses 1.75% 1.54% 1.75% 1.54% Provision for loan losses (000's) $ 4,200 $ 4,000 $ 1,500 $ 900 Non-Performing Loans (000's) $ 13,386 $ 14,776 $ 13,386 $ 14,776 Equity to Assets 8.27% 8.15% 8.27% 8.15% Efficiency Ratio 54.03% 55.43% 50.82% 53.40%
Dean Withers, President and CEO, commented, "This is our third consecutive year of earnings improvement and, for the first time since 2005, we have achieved record earnings on a nominal basis. While we are pleased with these results, this level of earnings does not reflect our pre-recession performance relative to traditional measures of Return on Assets and Return on Equity." Withers continued, "We are cautiously optimistic that 2013 will result in the further, slow progress in reducing non-performing loans. As I stated in our last quarterly earnings announcement, we are seeing signs of modest improvement in both the local housing and commercial real estate markets. However, we still believe at this time that it is important to build our reserves, as there are still some borrowers that are struggling to recover from the lingering effects of the recession."
Withers stated, "Economic activity in our markets appears to be picking up, as we've seen an improvement in recent loan demand. This improved demand crosses multiple business lines, as we are seeing good growth in our Dealer Finance Division, strong interest in our new Fishersville Loan Production Office and improved loan demand in our established markets. On January 17, 2013, our Board of Directors declared a fourth quarter dividend of $0.17 per share. This is an increase of $.01 per share, compared to the prior year and prior quarter. Based on our most recent trade price of $16 per share, this dividend constitutes a 4.25% yield on an annualized basis. The dividend will be paid on February 8, 2013, to shareholders of record as of January 29, 2013." Highlights of the company's financial performance are included below.
F & M Bank Corp. is an independent, locally-owned, community bank holding company, offering a full range of financial services, through its subsidiary, Farmers & Merchants Bank's nine banking offices in Rockingham, Shenandoah and Page Counties, Virginia. The Bank also provides additional services through two loan production offices located in Penn Laird, VA and Fishersville, VA and through its subsidiary, VBS Mortgage located in Harrisonburg, VA. Additional information may be found by contacting us on the internet at www.FMBankVA.com or by calling (540) 896-8941.
This press release may contain "forward-looking statements" as defined by federal securities laws, which may involve significant risks and uncertainties. These statements address issues that involve risks, uncertainties, estimates and assumptions made by management, and actual results could differ materially from the results contemplated by these forward-looking statements. Factors that could have a material adverse effect on our operations and future prospects include, but are not limited to, changes in: interest rates, general economic conditions, legislative and regulatory policies, and a variety of other matters. Other risk factors are detailed from time to time in our Securities and Exchange Commission filings. Readers should consider these risks and uncertainties in evaluating forward-looking statements and should not place undue reliance on such statements. We undertake no obligation to update these statements following the date of this press release.
F & M Bank Corp. Financial Highlights For Twelve Months Ended December 31 ---------------------------------- Unaudited Audited INCOME STATEMENT 2012 2011 ---------------- ---------------- Interest and Dividend Income $ 27,224,539 $ 27,680,179 Interest Expense 6,294,071 7,718,651 ---------------- ---------------- Net Interest Income 20,930,468 19,961,528 Non-Interest Income 3,704,153 3,178,195 Provision for Loan Losses 4,200,000 4,000,000 Other Non-Interest Expenses 13,361,377 12,891,818 ---------------- ---------------- Income Before Income Taxes & Securities Transactions 7,073,244 6,247,905 Securities Gains (Losses) 1,024,539 Provision For Income Taxes 2,026,193 2,522,728 Less Minority Interest 145,967 61,525 ---------------- ---------------- Net Income $ 4,901,084 $ 4,688,191 Average Shares Outstanding 2,496,300 2,449,864 Net Income Per Common Share 1.96 1.91 Dividends Declared .64 .60 Unaudited Audited December 31, December 31, BALANCE SHEET 2012 2011 ---------------- ---------------- Cash and Due From Banks $ 7,960,633 $ 6,813,243 Interest Bearing Bank Deposits 1,283,581 1,187,996 Federal Funds Sold 2,180,601 Loans Held for Sale 77,206,517 60,542,812 Loans Held for Investment 465,819,073 451,570,491 Less Allowance for Loan Losses (8,154,074) (6,936,904) ---------------- ---------------- Net Loans Held for Investment 457,664,999 444,633,587 Securities 18,807,173 22,107,621 Other Assets 33,981,232 29,268,015 ---------------- ---------------- Total Assets $ 596,904,135 $ 566,773,875 Deposits $ 453,795,539 $ 435,946,623 Short Term Debt 34,597,352 18,538,963 Long Term Debt 37,714,286 47,107,143 Subordinated Debt 10,191,000 10,191,000 Other Liabilities 11,221,998 8,770,427 ---------------- ---------------- Total Liabilities 547,520,175 520,554,156 Stockholders' Equity 49,383,960 46,179,719 ---------------- ---------------- Total Liabilities and Stockholders' Equity $ 596,904,135 $ 566,733,875 Book Value Per Common Share $ 19.76 $ 18.53
Neil Hayslett
Farmers & Merchants Bank
[email protected]
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...
Jun. 29, 2016 07:00 PM EDT Reads: 389
The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren't yet translating into a true "cloud" experience within the enterprise. What is stopping the growth of the "private cloud" market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between wh...
Jun. 29, 2016 05:30 PM EDT Reads: 1,029
SYS-CON Events has announced today that Roger Strukhoff has been named conference chair of Cloud Expo and @ThingsExpo 2016 Silicon Valley. The 19th Cloud Expo and 6th @ThingsExpo will take place on November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. "The Internet of Things brings trillions of dollars of opportunity to developers and enterprise IT, no matter how you measure it," stated Roger Strukhoff. "More importantly, it leverages the power of devices and the Interne...
Jun. 29, 2016 04:15 PM EDT Reads: 411
"We work in the area of Big Data analytics and Big Data analytics is a very crowded space - you have Hadoop, ETL, warehousing, visualization and there's a lot of effort trying to get these tools to talk to each other," explained Mukund Deshpande, head of the Analytics practice at Accelerite, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 29, 2016 04:15 PM EDT Reads: 394
The idea of comparing data in motion (at the sensor level) to data at rest (in a Big Data server warehouse) with predictive analytics in the cloud is very appealing to the industrial IoT sector. The problem Big Data vendors have, however, is access to that data in motion at the sensor location. In his session at @ThingsExpo, Scott Allen, CMO of FreeWave, discussed how as IoT is increasingly adopted by industrial markets, there is going to be an increased demand for sensor data from the outermos...
Jun. 29, 2016 04:00 PM EDT Reads: 348
UAS, drones or unmanned aircraft, no matter what you call them — this was their week. Our news stream was flooded with updates on the newly announced rules and regulations for commercial UAS from the FAA. So, naturally we have dedicated this week's top news round up to highlight some of our favorite UAS stories.
Jun. 29, 2016 03:02 PM EDT Reads: 264
Internet of @ThingsExpo has announced today that Chris Matthieu has been named tech chair of Internet of @ThingsExpo 2016 Silicon Valley. The 6thInternet of @ThingsExpo will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
Jun. 29, 2016 03:00 PM EDT Reads: 348
Basho Technologies has announced the latest release of Basho Riak TS, version 1.3. Riak TS is an enterprise-grade NoSQL database optimized for Internet of Things (IoT). The open source version enables developers to download the software for free and use it in production as well as make contributions to the code and develop applications around Riak TS. Enhancements to Riak TS make it quick, easy and cost-effective to spin up an instance to test new ideas and build IoT applications. In addition to...
Jun. 29, 2016 02:00 PM EDT Reads: 643
CenturyLink has announced that application server solutions from GENBAND are now available as part of CenturyLink's Networx contracts. The General Services Administration (GSA)'s Networx program includes the largest telecommunications contract vehicles ever awarded by the federal government. CenturyLink recently secured an extension through spring 2020 of its offerings available to federal government agencies via GSA's Networx Universal and Enterprise contracts. GENBAND's EXPERiUS™ Application...
Jun. 29, 2016 02:00 PM EDT Reads: 377
In addition to all the benefits, IoT is also bringing new kind of customer experience challenges - cars that unlock themselves, thermostats turning houses into saunas and baby video monitors broadcasting over the internet. This list can only increase because while IoT services should be intuitive and simple to use, the delivery ecosystem is a myriad of potential problems as IoT explodes complexity. So finding a performance issue is like finding the proverbial needle in the haystack.
Jun. 29, 2016 01:15 PM EDT Reads: 339
When people aren't talking about VMs and containers, they're talking about serverless architecture. Serverless is about no maintenance. It means you are not worried about low-level infrastructural and operational details. An event-driven serverless platform is a great use case for IoT. In his session at @ThingsExpo, Animesh Singh, an STSM and Lead for IBM Cloud Platform and Infrastructure, will detail how to build a distributed serverless, polyglot, microservices framework using open source tec...
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Apixio Inc. has raised $19.3 million in Series D venture capital funding led by SSM Partners with participation from First Analysis, Bain Capital Ventures and Apixio's largest angel investor. Apixio will dedicate the proceeds toward advancing and scaling products powered by its cognitive computing platform, further enabling insights for optimal patient care. The Series D funding comes as Apixio experiences strong momentum and increasing demand for its HCC Profiler solution, which mines unstruc...
Jun. 29, 2016 11:00 AM EDT Reads: 513
The IoT is changing the way enterprises conduct business. In his session at @ThingsExpo, Eric Hoffman, Vice President at EastBanc Technologies, discussed how businesses can gain an edge over competitors by empowering consumers to take control through IoT. He cited examples such as a Washington, D.C.-based sports club that leveraged IoT and the cloud to develop a comprehensive booking system. He also highlighted how IoT can revitalize and restore outdated business models, making them profitable ...
Jun. 29, 2016 11:00 AM EDT Reads: 471
Presidio has received the 2015 EMC Partner Services Quality Award from EMC Corporation for achieving outstanding service excellence and customer satisfaction as measured by the EMC Partner Services Quality (PSQ) program. Presidio was also honored as the 2015 EMC Americas Marketing Excellence Partner of the Year and 2015 Mid-Market East Partner of the Year. The EMC PSQ program is a project-specific survey program designed for partners with Service Partner designations to solicit customer feedbac...
Jun. 29, 2016 11:00 AM EDT Reads: 583
IoT offers a value of almost $4 trillion to the manufacturing industry through platforms that can improve margins, optimize operations & drive high performance work teams. By using IoT technologies as a foundation, manufacturing customers are integrating worker safety with manufacturing systems, driving deep collaboration and utilizing analytics to exponentially increased per-unit margins. However, as Benoit Lheureux, the VP for Research at Gartner points out, "IoT project implementers often ...
Jun. 29, 2016 10:45 AM EDT Reads: 558
"delaPlex is a software development company. We do team-based outsourcing development," explained Mark Rivers, COO and Co-founder of delaPlex Software, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
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In his general session at 18th Cloud Expo, Lee Atchison, Principal Cloud Architect and Advocate at New Relic, discussed cloud as a 'better data center' and how it adds new capacity (faster) and improves application availability (redundancy). The cloud is a 'Dynamic Tool for Dynamic Apps' and resource allocation is an integral part of your application architecture, so use only the resources you need and allocate /de-allocate resources on the fly.
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Connected devices and the industrial internet are growing exponentially every year with Cisco expecting 50 billion devices to be in operation by 2020. In this period of growth, location-based insights are becoming invaluable to many businesses as they adopt new connected technologies. Knowing when and where these devices connect from is critical for a number of scenarios in supply chain management, disaster management, emergency response, M2M, location marketing and more. In his session at @Th...
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Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, discussed how research has demonstrated the value of Machine Learning in delivering next generation analytics to imp...
Jun. 29, 2016 09:45 AM EDT Reads: 943
In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
Jun. 29, 2016 09:15 AM EDT Reads: 1,459


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Smallest toploader bag for Sony A99 + 24-70
phdstp wrote:
Thanks a lot for all the informations, for the accurate measurements and for the UK website.
I actually could not find a UK distributor, as I did not notice the distributor link on the website (it was small)...
I am ordering one from the website you mentioned, thanks again and have a nice day!
You are very welcome - I've been using the M-Rock system for a few years now and was very impressed when I had a dimension question a few years ago and sent them an email and the owner, Michael Rockwell (M-Rock) responded, and we've stayed in contact since. I have a set of three different bags from his new models, plus couple of his old ones. I have lens bags so I can easily add one to the holster bag, and I have one of the modular belts for when I go hiking with my two dogs. M-Rock used to make insulated water bottle pouches that attach to one of the bags or the modular belt and I have a couple of them which I attach to the belt, along with a small lens bag for the dog's treats, etc and the holster bag so I have someplace safe to easily put the camera in when I have to tend to the dogs.
Good luck and I hope it works out for you.
Gary C.
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Rep. Peter King (R-NY) became the first Republican to throw his hat in the ring for the 2016 presidential election. King announced his 'long-shot' candidacy Friday in New Hampshire, CBS News reports. He may be one of the longest serving congressmen, but that doesn't mean he will be elected the next POTUS. You will recall Peter King has called for the racial profiling of Muslims and wants President Obama to invade Syria.
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Central Districts will face their nemesis yet again this season when they square up to Wellington in a Twenty20 match at the Basin Reserve today.
Flogged by his bat earlier in the season, Central's bowlers will be hoping for a belated Christmas gift from Jesse Ryder in the form of a quick dismissal.
Central have yet to get their HRV Cup campaign properly under way.They fielded a couple of modest sides in their previous losses to Northern Districts and Wellington, but are not far off full strength today.
Jacob Oram will turn out for the first time this season and around him, the usual regulars of Jamie How and Mathew Sinclair will be on deck, while Adam Milne and Zimbabwean Kyle Jarvis should provide some penetration with the new ball.
Central's quick bowlers were appalling last time out against Wellington and surely won't be that bad again.
If fit to play, the returning Tarun Nethula and Kieran Noema-Barnett would add some welcome balance to the Stags' attack.
On paper, Wellington possess a balanced and talented side. But, if Ryder doesn't go big, then they don't tend to fire.
The Firebirds have a two win, two loss record so far, in which time they've also shown that their trait Ryder doesn't go big, then they don't tend to fire.
The Firebirds have a two win, two loss record so far, in which time they've also shown that their trait of shying away from the big moments hasn't changed.
Ryder, with 90 off 75 and 75 from 26, in their victories over Canterbury and Central Districts, took all the pressure off his team-mates.
Likewise, having Australian fast bowler Shaun Tait for that Canterbury game enabled the bowlers to quietly go about their work, safe in the knowledge that Tait was able to carry the attack on his broad shoulders.
The Firebirds flogged the Stags in this summer's previous meeting, winning by 55 runs in a one-sided encounter at McLean Park.
But they are coming off a poor effort against Otago – beaten by 82 runs on Sunday.
Wellington have decent imports in Tamim Iqbal and Chris Woakes, and, it appears, a Black Cap in the making in New Zealand-born Aussie wicketkeeper-batsman Luke Ronchi.
Scott Kuggeleijn is emerging as a late-middle order batsman of some prowess but his runs should be regarded as bonus ones at this stage of his career.
Elsewhere, Auckland host Northern at Eden Park, while Otago travel up to Timaru to meet Canterbury.
The Wizards have signed Aussie quick bowler Mitchell Claydon for the rest of their campaign, after the deal they had with West Indian Dwayne Smith fell through.
Claydon is a left-handed batsman and a right-arm medium pacer.
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From the classic corner….
Album Review: Something Worth Saving (McKameys)
We certainly live in troubled times, and the future often seems murky at best. In times like these, we need somewhere dependable to turn, a place tried and true. Thankfully, for the Christian, we have that perfect refuge in Jesus Christ. I believe that need applies to all areas of life, even music. I find it …View full post
Album Review: The Light (Barry Rowland & Deliverance)
This is my fourth review of a Barry Rowland & Deliverance recording in five years, and it's always a recording I look forward to. With The Light, Barry, his wife Tammy, and Shawn Rupert return with another collection of (mostly) Kyla Rowland compositions showcasing their signature Appalachian gusto. If anyone out there still isn't familiar with …View full post
Album Review: Pray for Me (Inspirations)
Did the year 2015 seem different to you, but you couldn't put your finger on why? I figured it out for you: best I can tell, it was the first calendar year in over two decades that the Inspirations did not release a new recording of exactly 10 songs. Never fear…the boys from Bryson City …View full post
2015 Year in Review: Top Albums
It seems impossible that it was a year ago that I was debating whether to name the Mark Trammell Quartet or Kingsmen CD as my favorite album of the year. But here we are again, looking back at all that 2015 offered us in the gospel music world. I'm obviously not a professional "critic" or …View full post
2015 Year in Review: Top Songs
I have not been able to write as much this year on the blog as in years past, due to church and job obligations occupying more of my time than ever. I hope in 2016 to be able to return to the frequency of posting as in years past. But I still listened to gospel …View full post
Feb 24
ebay gem .::. 2/24/10
Great opportunity to pick up some classic Kingdom Heirs material…
Feb 22
Mark Trammell Quartet "How Big Is God"
Great look at Pat Barker as the Trammell Trio reconfigures into a quartet.? Thanks to Diana at wwwSGConcerts.com for great videos, as always!!!
Feb 22
New Music Playlist (finally!)
I just finished uploading new music to our player at the bottom of the site.? Hope you enjoy it!
Song List:
- Hallelujah Side (Crossway)
- I Want My Stage To Be An Altar (The Akins)
- It's Hard To Stumble On Your Knees (Primitive Quartet)
- Treasures Unseen Medley (Message Trio)
- What's Waiting On The Other Side (Cumberland Quartet)
Feb 11
ebay gem .::. 2/11/10
As if the Cathedrals Live In Atlanta wasn't enough…this auction is packed with Southern Gospel goodies.
Feb 05
Gold City "When He Blessed My Soul" & "Where Is God?"
After a month or so of singing together, the new Gold City is sounding awesome.? Josh Cobb may even make a fan out of me yet :-)!? This rendition of "When He Blessed My Soul" is spectacular.
Thanks to Diana (www.SGConcerts.com) for posting her awesome videos!!!
Here's another video of a classic Kyla Rowland song, "Where Is God?".


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Posts Tagged 'Roadburn'
The Unexpected Hightlights of Roadburn 2016 Pt.1: Oranssi Pazuzu
Posted on Friday, April 22nd, 2016
Our first unexpected highlight was not an entirely unexpected one, if we're honest. We were anticipating great things from Oranssi Pazuzu, but what was so overwhelming about the performance was how many other people got caught swept up in the positivity and the incredible vibe of the show.
That feeling resonated for a long time afterwards, there was quite a buzz throughout the festival!
"The line to see Oranssi Pazuzu inside Het Patronaat was massive even by Roadburn terms, so it was pure luck that landed me inside close to the stage as Finland's finest (and only) purveyors of psychedelic black metal sent the rest of the faithful packed inside the church walls into an ecstatic trance. Sweat, strobe lights and pounding rhythms dominated, scales were mangled and transformed, bodies hurled themselves across the stage, and Oranssi Pazuzu proved yet again that they're one of the most compelling live acts in the world. It's hard to describe what it's like to see them play—fan-shot video gives you a slight idea of the chaotic aspect, but really, you just need to see them for yourself" – Kim Kelly / editor at Noisey.
Tags: Kim Kelly, Noisey, Oranssi Pazuzu, Roadburn, Roadburn 2016, Roadburn Festival, Roadburn Festival 2016
Posted in 2016, Roadburn Recommended, Videos | No Comments »
Roadburn Festival 2016: Daily Video Reports
Posted on Tuesday, April 19th, 2016
Over the course of the festival, Mark208 worked around the clock to film, edit and put up daily videos. His awesome videos have captured the vibe of the festival perfectly. Relive the memories below, and stay on planet Roadburn for just a bit longer.
Roadburn Festival 2016: The Emotional Connection Has Never Been Stronger
Posted on Monday, April 18th, 2016
Roadburn 2016 was the first edition to take place in the new and improved 013 venue. We were overwhelmed by how well the line up came together, how many of you were supportive and bought tickets – we knew it was going to be a great edition before it started […]
A-Z of Roadburn 2016: Everything You Need To Know!
Posted on Wednesday, April 6th, 2016
We've gathered together all of the essential information to ensure that your Roadburn experience goes without a hitch this year. A – Access! First thing's first! You will need to swap your ticket for a wristband before you can access the festival stages. Because we have Cult of Luna playing […]
Roadburn Festival 2016: Costin Chioreanu's Offical Poster Art
Posted on Wednesday, April 6th, 2016
In keeping with tradition, Costin Chioreanu has set the visual tone for some bands playing Roadburn Festival 2016. Costin has cast his creative spell over some of his favourite artists on the Roadburn bill, and once again he has more than delivered. We are proud to unveil his official posters […]
Roadburn 2016 Official Exhibition: The World of Becky Cloonan
Posted on Wednesday, March 30th, 2016
It's no secret that Roadburn has a strong leaning towards art and creativity, and we're proud to announce that a new chapter in our ever-evolving love affair with music and art comes to fruition at this year's festival. For 2016, Becky Cloonan has created our incredible artwork, and with her […]
Roadburn Festival To Release Burning Up With… The Heads, Live at Roadburn 2015
Posted on Thursday, March 24th, 2016
Over the years, it's become a well-loved tradition that there will be a vinyl release, sold exclusively at the festival. This year is no exception, as once again we have a very special release for you. Last year as artist in residence The Heads played two sets, one in Het […]
Song Premiere: Sinistro – Relíquia; Band To Play Roadburn 2016
Posted on Friday, January 29th, 2016
This afternoon, we're pleased to bring you the premiere of a brand new Sinistro track. Taken from their forthcoming album, Semente, due out via Season of Mist on April 8th, 'Relíquia' is the first track to be unveiled. Sinistro: "Relíquia is about an old lady revisiting past memories and daydreaming about […]
Jurgen van den Brand Parts Ways With Roadburn Festival To Focus On Other Ventures
Posted on Thursday, January 28th, 2016
The start of 2016 comes with a notable change for Roadburn Festival. After many years of working together, Jurgen van den Brand will no longer be involved with the festival nor the Roadburn website. From now on he will be focusing on his record-labels; Roadburn Records, Burning World, and his […]
Roadburn 2016: Day Posters By Becky Cloonan Revealed
Posted on Tuesday, December 22nd, 2015
As well as creating our overall festival poster, renowned comic book artist, Becky Cloonan, has also created individual posters for each day of Roadburn. Below are the four posters that Becky has made for us (and laid out by Costin Chioreanu). She comments: "As an illustrator and cartoonist I love […]


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It's a tee. It's a dress. It's the new Graphic T-shirt Dress.
Just having fun with my programs. On the other hand it might show what actually goes on inside my head…. ha ha :-)
chess fantasy glass hour piece strange wacky weird world
hahaha – that you are wacked out? =) This is very interesting……….. and I can tell it was fun!
Beautiful work Annika, you have an amazing imagination… ;-)
You are scaring me, Annika….
clever one!! Beautiful work, fantastic imagery and colours, beautifully done
MG, what are you thinking smiles…..
Wacky & wonderful! Great w.o.a.!
Thank you so much everyone! :-)
wonderful art, so much to see
Thank you Henk! :-)
thats really cool love it
Thank you so much igo! :-)
this has a hint of Salvador Dali about it.. realy good :)
Thank you Carrie! :-)
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Glenwood Jobs
Looking for jobs in Glenwood? Snagajob has great opportunities with the area's leading companies. And applying for Glenwood jobs has never been easier. Look at the job listings below, click on a job title that interests you and hit the "apply now" button. Part-time jobs, teen jobs, student jobs and summer jobs are now just a click away. Start your job search now.
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Salman, Katrina starrer `Ek Tha Tiger` to release Aug 15
Last Updated: Wednesday, June 27, 2012 - 08:38
Mumbai: Romantic-thriller `Ek Tha Tiger` starring Salman Khan and Katrina Kaif will hit theatres on Independence Day, Aug 15, while its trailers will be unveiled Wednesday.
The new trailer will be released online and can be seen on YouTube after 12 noon and in theatres Friday.
Directed by Kabir Khan and produced by Aditya Chopra, the film will see Salman-Katrina pair on silver screen after four years. Their last film together was 2008 release `Yuvvraaj`.
First Published: Wednesday, June 27, 2012 - 08:38
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During the great California gold rush, early prospectors sifted through rocks and streams in the hopes of finding a fortune. But bigger hauls were often claimed by going below the surface and digging deeply into mines, where a treasure trove of gold lay waiting to be unearthed. The gold rush may be ancient history, but there's still potential treasure to be tapped--and crises that can be prevented too-by companies that are willing to delve deep into their dark data.
Oct 23, 2007
EBSCO A-to-Z customers who also subscribe to EBSCOhost Electronic Journal Service (EJS) can now view their EJS holdings within their A-to-Z title listing service. This is intended to allow end-users to browse tables of content and view article-level details for many of their e-journals, all while remaining within the A-to-Z interface.


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Bollywood Brunch- Special Scene For Sanjay In Zanjeer, Aaradhya To Walk For Cannes And More
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Brazilian Journal of Medical and Biological Research
[SJR: 0.431] [H-I: 62] [0 followers] Follow
Open Access journal
ISSN (Print) 0100-879X - ISSN (Online) 1414-431X
Published by SciELO [727 journals]
- Brain caspase-3 and intestinal FABP responses in preterm and term rats
submitted to birth asphyxia
Abstract: Neonatal asphyxia can cause irreversible injury of multiple organs resulting in hypoxic-ischemic encephalopathy and necrotizing enterocolitis (NEC). This injury is dependent on time, severity, and gestational age, once the preterm babies need ventilator support. Our aim was to assess the different brain and intestinal effects of ischemia and reperfusion in neonate rats after birth anoxia and mechanical ventilation. Preterm and term neonates were divided into 8 subgroups (n=12/group): 1) preterm control (PTC), 2) preterm ventilated (PTV), 3) preterm asphyxiated (PTA), 4) preterm asphyxiated and ventilated (PTAV), 5) term control (TC), 6) term ventilated (TV), 7) term asphyxiated (TA), and 8) term asphyxiated and ventilated (TAV). We measured body, brain, and intestine weights and respective ratios [(BW), (BrW), (IW), (BrW/BW) and (IW/BW)]. Histology analysis and damage grading were performed in the brain (cortex/hippocampus) and intestine (jejunum/ileum) tissues, as well as immunohistochemistry analysis for caspase-3 and intestinal fatty acid-binding protein (I-FABP). IW was lower in the TA than in the other terms (P<0.05), and the IW/BW ratio was lower in the TA than in the TAV (P<0.005). PTA, PTAV and TA presented high levels of brain damage. In histological intestinal analysis, PTAV and TAV had higher scores than the other groups. Caspase-3 was higher in PTAV (cortex) and TA (cortex/hippocampus) (P<0.005). I-FABP was higher in PTAV (P<0.005) and TA (ileum) (P<0.05). I-FABP expression was increased in PTAV subgroup (P<0.0001). Brain and intestinal responses in neonatal rats caused by neonatal asphyxia, with or without mechanical ventilation, varied with gestational age, with increased expression of caspase-3 and I-FABP biomarkers.
- Predictors of early treatment discontinuation and severe anemia in a
Brazilian cohort of hepatitis C patients treated with first-generation
protease inhibitors
Abstract: The aim of this study was to determine risk factors for adverse events (AE)-related treatment discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor (PI)-based therapy. We included all patients who initiated treatment with PI-based therapy at a Brazilian university hospital between November 2013 and December 2014. We prospectively collected data from medical records using standardized questionnaires and used Epi Info 6.0 for analysis. Severe anemia was defined as hemoglobin ≤8.5 mg/dL. We included 203 patients: 132 treated with telaprevir (TVR) and 71 treated with boceprevir (BOC). AE-related treatment discontinuation rate was 19.2% and anemia was the main reason (38.5%). Risk factors for treatment discontinuation were higher comorbidity index (OR=1.85, CI=1.05-3.25) for BOC, and higher bilirubin count (OR=1.02, CI=1.01-1.04) and lower BMI (OR=0.98, CI=0.96-0.99) for TVR. Severe anemia occurred in 35 (17.2%) patients. Risk factors for this outcome were lower estimated glomerular filtration rate (eGFR; OR=0.95, CI=0.91-0.98) for patients treated with TVR, and higher comorbidity index (OR=2.21, CI=1.04-4.67) and ribavirin dosage (OR=0.84, CI=0.72-0.99) for those treated with BOC. Fifty-five (57.3%) patients treated with TVR and 15 (27.3%) patients treated with BOC achieved sustained virological response (SVR). Among patients who received TVR and interrupted treatment due to AE (n=19), only 26.3% (n=5) achieved SVR (P=0.003). Higher number of comorbidities, lower eGFR and advanced liver disease are associated with severe anemia and early treatment cessation, which may compromise SVR achievement.
- Peripheral brain-derived neurotrophic factor is related to cardiovascular
risk factors in active and inactive elderly men
Abstract: Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min Åstrand-Rhyming bike test, the subjects were classified into active and inactive groups. The young and elderly active men had a significantly better lipoprotein profile and antioxidant status, as well as reduced oxidative damage and inflammatory state. The active young and elderly men had significantly higher plasma BDNF levels compared to their inactive peers. BDNF was correlated with VO2max (r=0.765, P<0.001). In addition, we observed a significant inverse correlation of BDNF with atherogenic index (TC/HDL), hsCRP and oxLDL. The findings demonstrate that a high level of cardiorespiratory fitness reflected in VO2max was associated with a higher level of circulating BDNF, which in turn was related to common CVD risk factors and oxidative damage markers in young and elderly men.
- Effects of lung cancer cell-associated B7-H1 on T-cell proliferation
in vitro and in vivo
Abstract: B7 homolog 1 (B7-H1) is the most potent immunoinhibitory molecule in the B7 family. In this study, we examined the effects of tumor-associated B7-H1 on T-cell proliferation in lung cancer. The expression of B7-H1 in human adenocarcinoma A549 and mouse Lewis lung carcinoma (LLC) cells were examined by flow cytometry. To assess the in vitro effect of tumor-associated B7-H1 on T-cell proliferation, we isolated T cells from peripheral blood mononuclear cells (PBMCs) of healthy individuals, labeled them with carboxyfluorescein succinimidyl ester, and co-cultured them with A549 cells in the absence or presence of anti-B7-H1 antibody. For in vivo analysis, LLC cells were subcutaneously injected into mice treated or not with anti-B7-H1 antibody. T-cell proliferation in both in vitro and in vivo assays was analyzed by flow cytometry. In vitro, co-culturing T cells with A549 cells significantly inhibited the proliferation of the former compared with the proliferation of T cells alone (P<0.01), and the addition of B7-H1 blocking antibody dramatically reversed the inhibition of T-cell proliferation by A549 cells. Similarly, in mice bearing LLC-derived xenograft tumors, in vivo administration of anti-B7-H1 antibody significantly increased the total number of spleen and tumor T cells compared to levels in control mice that did not receive anti-B7-H1 antibody. Functionally, in vivo administration of anti-B7-H1 antibody markedly reduced tumor growth. Tumor-associated B7-H1 may facilitate immune evasion by inhibiting T-cell proliferation. Targeting of this mechanism offers a promising therapy for cancer immunotherapy.
- Association of terpinolene and diclofenac presents antinociceptive and
anti-inflammatory synergistic effects in a model of chronic inflammation
Abstract: Pharmacological treatment of inflammatory pain is usually done by administration of non-steroidal anti-inflammatory drugs (NSAIDs). These drugs present high efficacy, although side effects are common, especially gastrointestinal lesions. One of the pharmacological strategies to minimize such effects is the combination of drugs and natural products with synergistic analgesic effect. The monoterpene terpinolene (TPL) is a chemical constituent of essential oils present in many plant species, which have pharmacological activities, such as analgesic and anti-inflammatory. The association of ineffective doses of TPL and diclofenac (DCF) (3.125 and 1.25 mg/kg po, respectively) presented antinociceptive and anti-inflammatory effects in the acute (0, 1, 2, 3, 4, 5 and 6 h, after treatment) and chronic (10 days) inflammatory hyperalgesia induced by Freund's complete adjuvant (CFA) in the right hind paw of female Wistar rats (170-230 g, n=6-8). The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds. The development of edema was quantified by measuring the volume of the hind paw by plethismography. The TPL/DCF association reduced neutrophils, macrophages and lymphocytes in the histological analysis of the paw, following a standard staining protocol with hematoxylin and eosin and the counts were performed with the aid of optical microscopy after chronic oral administration of these drugs. Moreover, the TPL/DCF association did not induce macroscopic gastric lesions. A possible mechanism of action of the analgesic effect is the involvement of 5-HT2A serotonin receptors, because ketanserin completely reversed the antinociceptive effect of the TPL/DCF association. These results suggest that the TPL/DCF association had a synergistic anti-inflammatory and analgesic effect without causing apparent gastric injury, and that the serotonergic system may be involved in the antinociceptive effect of this association.
- Effect of exercise training on ventilatory efficiency in patients with
heart disease: a review
Abstract: The analysis of ventilatory efficiency in cardiopulmonary exercise testing has proven useful for assessing the presence and severity of cardiorespiratory diseases. During exercise, efficient pulmonary gas exchange is characterized by uniform matching of lung ventilation with perfusion. By contrast, mismatching is marked by inefficient pulmonary gas exchange, requiring increased ventilation for a given CO2 production. The etiology of increased and inefficient ventilatory response to exercise in heart disease is multifactorial, involving both peripheral and central mechanisms. Exercise training has been recommended as non-pharmacological treatment for patients with different chronic cardiopulmonary diseases. In this respect, previous studies have reported improvements in ventilatory efficiency after aerobic exercise training in patients with heart disease. Against this background, the primary objective of the present review was to discuss the pathophysiological mechanisms involved in abnormal ventilatory response to exercise, with an emphasis on both patients with heart failure syndrome and coronary artery disease. Secondly, special focus was dedicated to the role of aerobic exercise training in improving indices of ventilatory efficiency among these patients, as well as to the underlying mechanisms involved.
- Fluorescent membrane markers elucidate the association of Borrelia
burgdorferi with tick cell lines
Abstract: This study aimed to describe the association of Borrelia burgdorferi s.s. with ixodid tick cell lines by flow cytometry and fluorescence and confocal microscopy. Spirochetes were stained with a fluorescent membrane marker (PKH67 or PKH26), inoculated into 8 different tick cell lines and incubated at 30°C for 24 h. PKH efficiently stained B. burgdorferi without affecting bacterial viability or motility. Among the tick cell lines tested, the Rhipicephalus appendiculatus cell line RA243 achieved the highest percentage of association/internalization, with both high (90%) and low (10%) concentrations of BSK-H medium in tick cell culture medium. Treatment with cytochalasin D dramatically reduced the average percentage of cells with internalized spirochetes, which passed through a dramatic morphological change during their internalization by the host cell as observed in time-lapse photography. Almost all of the fluorescent bacteria were seen to be inside the tick cells. PKH labeling of borreliae proved to be a reliable and valuable tool to analyze the association of spirochetes with host cells by flow cytometry, confocal and fluorescence microscopy.