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text:
|Publication number
|Publication type
|Application number
|Publication date
|Jan 18, 2011
|Filing date
|Jul 26, 2005
|Priority date
|Jul 26, 2004
|Fee status
|Also published as
|Publication number
|Kyung A. Kang
|Original Assignee
|University Of Louisville Research Foundation, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Non-Patent Citations (23), Referenced by (2), Classifications (41), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application claims the benefit of U.S. Provisional Application Ser. No. 60/590,992, filed Jul. 26, 2004, under 35 U.S.C. §19.
A field of the invention is biosensing and bioimaging.
Biomarkers used for disease diagnoses are usually present in bio-samples with a wide variety of other biomolecules, some of which are structurally homologous to the biomarkers themselves. In addition, the levels of the biomarkers in a sample are usually extremely low. Therefore, sensors to detect these biomolecules must be both very sensitive and specific.
Fluorophores have been valuable tools in biosensing/bioimaging for disease screening, diagnosis and monitoring. However, the low quantum yield (QY) of some of these fluorophores caused by non-radiative decay, especially by self-quenching, limits the effectiveness of these fluorophores in biosensing/bioimaging applications. Enhancement of the fluorescence can, therefore, improve the sensitivity of fluorophore-mediated biosensing and bioimaging.
Embodiments of the invention include a device and method for enhancing fluorescence emission in fluorophore-mediated biosensors. An exemplary method includes conducting a fluorophore-mediated sandwich immunoassay and exposing a flurophore-linked sandwich complex to an enhancing agent, such as a nanometal particle surrounded by a layer having a predetermined thickness (e.g., a self-assembled monolayer, surfactant or peptide), an organic, biocompatible solvent, or a combination of the nanometal particle with the self-assembled monolayer and the organic, biocompatible solvent. Another exemplary embodiment of the invention includes a biological sensor having enhanced fluorescence emission that includes an optical fiber having a fluorophore-mediated sandwich immunoassay disposed thereon, a chamber having at least one opening through which said fiber may extend, with an enhancing agent disposed in the chamber. The enhancing agent may be a nanometal particle a layer of predetermined thickness, an organic biocompatible solvent, or a combination of the nanometal particle having the layer of predetermined thickness, and the organic, biocompatible solvent.
Fluorescence of a fluorophore is normally limited by self-quenching of the free electrons in the fluorophore, thereby limiting the sensitivity of biosensors with which they are used. Embodiments of the invention reduce or eliminate this self-quenching, which enhances fluorescence emission of the fluorophore, thereby enhancing the ability to detect the presence of and quantify a target analyte. Fluorescence of some fluorophores and of fluorophore mediated biosensors is also enhanced significantly by biocompatible organic solvents. Devices and methods of the invention include exposing a fluorophore-mediated sandwich immunoassay to an enhancing agent, where the enhancing agent may be a nanometal particle having a layer of predetermined thickness, an organic, biocompatible solvent, or a combination of both a nanometal particle having a layer of predetermined thickness and an organic, biocompatible solvent.
Electrons of fluorophores that are normally involved in self-quenching upon photoexcitation may be coupled to strong surface plasmon polaritron fields of metallic nanoparticles, e.g., gold, silver, platinum and copper nanoparticles. Fluorescence can be maximized when a fluorophore is placed at a particular distance from the nanoparticle, wherein the particular distance may be empirically determined.
Embodiments of the invention exploit the surface plasmon polaritron fields of metallic nanoparticles, such as nanogold particles, nanosilver particles, nanoplatinum particles and nanocopper particles, for example, to enhance fluorescence. When plasmon rich, sharp metal tips or nanometal particles are placed at a particular distance from a fluorophore in accordance with the invention, they enhance the fluorescence by several fold, possibly by removing the cause of static or Foester quenching. This fluorescence enhancing effect can be artificially induced when a fluorophore is placed next to a metal particle treated with, for example, a self-assembled monolayer at a particular thickness. It is anticipated that the metal nanoparticle may be treated with a number of substances to obtain a layer having a predetermined thickness, such as a self-assembled monolayer, a surfactant, or a peptide, to name a few. The self-assembled monolayer will be discussed herein for purposes of illustration.
When placed at an appropriate, predetermined distance from a fluorophore, the metallic nanoparticles can effectively enhance fluorescence by transferring the free electrons of the fluorophore, electrons normally used for self-quenching, to the strong surface plasmon polaritron fields. If the metallic nanoparticle is placed too close to the fluorophore, the metallic nanoparticle extracts all electrons in the excited state from the fluorophore, including the ones for radiative emission. Alternatively, when the metallic nanoparticle is placed too far from the fluorophore, the surface plasmon polaritron fields may not reach the fluorophore, and there will be no effect on the resulting fluorescence intensity. However, when the appropriate predetermined distance is maintained between the metallic nanoparticle and the fluorophore via a predetermined mechanism, the fluorescence may be enhanced as the electrons normally used for self-quenching are transferred.
With application of embodiments of the invention, the sensitivity of the fluorophore mediated biosensor increases by several folds, which enables sensors with much higher sensitivity; increased accuracy diagnoses—fewer false positives or negatives; and minimization of the sensor size and assay time. Embodiments of the invention provide either fluorescence-enhancing nanometal particles, organic, biocompatible solvents, or a combination of both.
In embodiments using nanometal particles only, the invention contemplates using a variety of metallic nanoparticles, such as nanogold particles and nanosilver particles, nanoplatinum particles and nanocopper particles. However, for exemplary purposes, nanogold particles and nanosilver particles will be discussed herein for purposes of illustration. In a first preferred embodiment, a self-assembled monolayer of a predetermined thickness on the nanogold surface ("nanogold particle-self-assembled monolayer") or nanosilver particle surface ("nanosilver particle-self-assembled monolayer") is used to maintain the appropriate predetermined distance between the nanogold particle or nanosilver particle and the fluorophore. The self-assembled monolayer may include one of a plurality of molecules, preferably those water soluble, organic molecules with a thiol or amine terminal group in their structures, that may self-assemble onto the nanoparticles. For example, two such molecules are L-Glutathione and 16 mercaptohexadecanoic acid.
Other embodiments of the invention utilize one or more organic solvents to affect the fluorescence intensity in biosensing applications, even without exposure to nanometal particles having self-assembled monolayers. To maximize the fluorescence, embodiments of the invention include biocompatible organic solvents combined with metallic nanoparticles, such as nanogold particle reagents (NGPRs). Experiments have shown that organic solvents enhance fluorescence intensity. Without limiting the invention in any way, and only as a potential explanation of the mechanism for the enhancement, it is believed that organic solvents, such as ethanol, affect fluorescence intensity by 1) shifting the excitation/emission spectra of the fluorophore, 2) by the isomerization of the fluorophore, 3) by shrinking the fluorophore tagged proteins, or 4) by a combination of the three mechanisms. Preferred solvents include a solution that includes nanometal particles of less than 100 nm having self-assembled monolayers assembled thereon.
Still other embodiments include the use of one or more organic solvents in addition to maintaining a predetermined distance between the nanometal particle and the fluorophore using a self-assembled monolayer, where the effect of solvent on the level of fluorescence enhancement is additive. In one embodiment, use of the combination of nanogold particles having a self-assembled monolayer and a biocompatible solvent increase the signal of a fiber-optic biosensor as much as ten times, and can accurately quantify various cardiac markers at a tens of picomolar level.
Yet another preferred embodiment includes one or more organic solvents in combination with a SAM of a predetermined thickness to enhance fluorescence.
Embodiments of the invention are contemplated for sensing applications involving a virtually unlimited number of target analyte, especially proteins such as cardiac markers. For example, Cardiac Troponin I (cTnI) and Human B-type natriuretic peptide (BNP) are two cardiac markers that are very important for rapid and accurate heart attack diagnoses and prognosis. Protein C is a plasma anticoagulant and the accurate quantification can diagnose the genetic disorder, Protein C deficiency. The same principals may be used to diagnose various cancers.
Turning to
By way of example only, a Protein C (PC) immuno-biosensor 28 for diagnosing a disease, PC deficiency, will be particularly described using
A preferred embodiment uses nanosilver particles as an enhancer. While different sized nanosilver particles may be used, an approximately 20 nm sized nanosilver particles is illustrated, since it is the smallest commercially available nanosilver particle, though alternatively sized nanosilver particles are contemplated to suit individual applications as smaller particles become commercially available.
Twenty nm nanosilver particles and the nanosilver particle reagent (NSPR) are also contemplated for use with the fluorophore-mediated BNP biosensor, as illustrated in
Other embodiments of the instant invention include biocompatible solvents that enhance the fluorescence signal. Numerous solvents are anticipated, preferably those solvents that are biosensor compatible (i.e., not affecting the antibody affinity) and which do not prevent reusability of the fiber. While numerous organic solvents are contemplated for use with the invention, one preferred solvent is ethanol.
One particularly advantageous solvent is ethanol, which will be discussed for exemplary purposes.
To illustrate with a specific example, the Protein C (PC) sensing system, a fluorophore such as either Cyanine 5 (CY5™) or ALEXA FLUORO™ fluorescent dye 647 (AF647) is conjugated with 2° Mab. The invention should not be construed as being limited to the fluorophores Cyanine 5 (CY5™) and AF647, as additional fluorophores are also contemplated for use with the invention. For example, ATTO 647, BODIPY™ 650/665 dye and DY-636 are additional potential fluorophores that may be used with the invention, to name a few. Cyanine 5 (CY5™) and AF647 were selected because they have very similar maximum excitation wavelengths (647 and 650 nm, respectively), but the quantum yield for AF647 is approximately twice of that for Cyanine 5 (CY5™). Therefore, the enhanced signal intensity for AF647 by nanogold particle-self-assembled monolayers is expected to be lower than that for Cyanine 5 (CY5™).
The intensity of the emission light generated from fluorophore-2° Mab quantifies the amount of PC in the sample. If the emission intensity by fluorophore-2° Mab is enhanced by even a few folds, then the sensor can become much more sensitive by increasing the signal to noise ratio (S/N ratio). Four different test cases are as shown in
According to one embodiment of the invention, 5 nm sized nanogold particles are used. Nanogold particles are linked (treated) with two different lengths, 2 or 3 nm, of a self-assembled monolayer (SAM) and mixed with fluorophores, Cyanine 5 (CY5™) or AF647. Again, these two fluorophores were selected because they have very similar maximum excitation wavelengths.
The fluorescence from the mixture of fluorophore and nanogold particle-self-assembled monolayer was first measured using the tip of an optical fiber, as shown in
Materials and Methods
Nanogold Particles-Self-Assembled Monolayer and NGPR Preparation
Nanogold colloids, which are nanogold particles (2, 5 and 10 nm) coated with tannic acid (surfactant, approximately 3 nm) were obtained. The thickness of a surfactant layer or self-assembled monolayer was theoretically estimated. L-Glutathione (approximately 1 nm) and 16 mercaptohexadecanoic acid (approximately 2 nm) were used as self-assembled monolayers. The self-assembled monolayer of L-glutathione or 16 mercaptohexadecanoic acid was linked on the surface of the nanogold particles by dissolving these molecules in distilled water or dimethyl sulfoxide; transferring them to the nanogold colloids; heating the mixture up to 70° C.; stirring them for 5 h; and purifying the products to eliminate the unreacted self-assembled monolayer molecules and replaced surfactant molecules. The NGPRs were produced by mixing the nanogold particles-self-assembled monolayers and the solvent to be tested.
Biosensor Preparation
Fluorophores, FLUOROLINK™ fluorescent product, Cyanine 5 (CY5™) and ALEXA FLUOR™ fluorescent dye 647 (AF647), were obtained. The Cyanine 5 (CY5™) or AF647 solution was prepared by dissolving the solid fluorophores in distilled water. A fluorometer with a long pass 670 nm filter inside and quartz fibers were used for sensors. Protein C and anti-PC monoclonal antibodies were obtained. Human B-type natriuretic peptide (BNP) and anti-BNP monoclonal antibodies were obtained. Cardiac Troponin I (cTnI) and anti-cTnI monoclonal antibodies were obtained. The PC sensor, PC samples, and fluorophore conjugated second antibody (fluorophore-2° Mab) were prepared.
Assay Protocol
The fluorescence of the free fluorophore in the phosphate buffer solution (PBS; control) or in the mixtures with nanogold particles-self-assembled monolayers or NGPRs was measured using a quartz fiber whose tip was polished at 45°. The fluorescence enhancement was also investigated with a fiber-optic PC sensor, which was developed for PC deficiency diagnosis. The sensor performs a fluorophore-mediated sandwich immunoassay on the sensor surface, and the fluorescence intensity is correlated with the PC concentration in blood plasma. Conventional assay protocol was used as a control: (1) sample injection and convective incubation, 0.5 min; (2) sensor washing and baseline measurement, 1 min.; (3) fluorophore-2° Mab injection and convective incubation, 2 min; (4) sensor washing and fluorescence measurement, 1 min.; (5) sensor regeneration, 1 min, and then the sensor is ready for the next assay. The signal used for the analyte quantification is the fluorescence measured in the step (4) subtracted by the baseline signal measured in the step (2).
For testing nanogold particles-self-assembled monolayers, solvents, or NGPRs, the protocol was modified to: (1′) nanogold particles-self-assembled monolayers, solvents or NGPRs injection and baseline measurement, 0.5 min; (2′) sensor washing, 0.5 min; (3′) sample injection and convective incubation, 0.5 min; (4′) sensor washing, 0.5 min; (5′) fluorophore-2° Mab injection and convective incubation, 2 min; (6′) sensor washing, 0.5 min; (7′) nanogold particles-self-assembled monolayers, solvents or NGPRs injection and fluorescence measurement, 0.5 min.; (8′) sensor washing and regeneration, 1.5 min. The fluorescence used for PC quantification is the value measured in the step (7′) subtracted by that measured in the step (1′).
Results and Discussion
Effects of the distance between a fluorophore and an NGP, and the NGP size on the fluorescence enhancement were studied. Since the concentration of the fluorophore and the NGP in a sample may also determine the distance, their concentrations were first adjusted to place them close enough to interact but not too crowded for quenching. The concentration ranges of the fluorophore and the nanogold particles used for this study were 10−8 to 10−7 and 10−10 to 10−7M, respectively. The fluorescence enhancement is defined as the increase in fluorescence by the enhancer divided by the fluorescence intensity without the enhancer.
The Effect of the Distance Between an NGP and a Fluorophore
Turning to
The Effect of the Nanogold Particle Size
The effect of the nanogold particle size (2, 5 or 10 nm) was investigated at a constant SAM thickness of 3 nm (
Among the nanogold particle-self-assembled monolayers test (nanogold particle size of 2, 5 and 10 nm and self-assembled monolayer thickness of 1, 2 and 3 nm), 5 nm nanogold particles linked with 2 nm self-assembled monolayers (5 nm NGP-SAM 2 nm) were found to be the best enhancer.
The Effect of the Quantum Yield of a Fluorophore
Because it has been theorized that the fluorescence enhancement by nanogold particles is by retrieving the fluorescence that is normally self-quenched, it was expected that the amount of the enhanced fluorescence would depend upon the quantum yield (QY) of a fluorophore. To verify the theory, two fluorophores with the similar excitation/emission wavelengths, but with different QYs, were tested. Cyanine 5 (CY5™) (excitation/emission wavelengths: 649/670 nm) used in previous studies has a QY of 0.28. AF647 has excitation and emission wavelengths (649/666 nm) very similar to those of Cyanine 5's (CY5™), but has a QY of two times greater than that of Cyanine 5 (CY5™). The fluorescence enhancement of free AF647 by 5 nm nanogold particle-self-assembled monolayer 3 nm were studied and the results were compared with those of Cyanine 5's (CY5™). Free AF647 exhibited a significantly less enhancement (3±3%) than that of free Cy5 (30±5%). Also, in the AF647 mediated biosensing, as expected, there was very little enhancement. These results confirmed the hypothesis that the level of fluorescence enhancement by nanogold particles-self-assembled monolayers depends on the QY of the fluorophore.
The Solvent Effect
Various physical/chemical properties of organic solvents, such as viscosity, polarity, etc., may also affect the fluorescence. Three solvents which were considered to be not too harsh to biomolecules were ethanol, methanol and THF. These solvents were tested. When free Cyanine 5 (CY5™) was dissolved in ethanol, 92±4% enhancement was obtained, while signal reduction was exhibited in methanol and THF. This may be caused by the different solvent polarity and the behavior of hydrogen-bonds. However, 318±19, 166±21, and 434±32% of enhancements were achieved in PC sensing by ethanol, methanol and THF, respectively, implying the presence of other enhancing mechanisms for immobilized, protein-linked fluorophores. Although THF showed the highest enhancement in PC sensing, it affected the biosensor reusability (reduced from 7 to 4 times), possibly by permanently denaturing of 1° Mab molecules on the sensor surface. Ethanol appeared to be a desired enhancer because it did not affect the reusability. n-Butanol was found to be an even better enhancer. It also worked very well with AF647 both in the free form (90±4% enhancement) and the PC sensing (>100%), while the fluorescence of this fluorophore was not enhanced by nanogold particles-self-assembled monolayers (
The Enhancement by NGPR
To maximize the enhancement effect, the two enhancers, the nanogold particles-self-assembled monolayers and the solvent, were mixed (NGPRs) and tested for their enhancement capacity. For 5 nm nanogold particles-self-assembled monolayers 3 nm mixed with ethanol, a 126±12% enhancement was demonstrated for free Cyanine 5 (CY5™), which appeared to be additively contributed from the enhancement by 5 nm nanogold particles-self-assembled monolayer 3 nm (30±5%) and by ethanol (94±9%) (
The Cardiac Marker Biosensing with NGPR
Fiber-optic biosensors are currently being developed to quantify cTnI and BNP in plasma, in their clinically significant ranges (31-310 and 26-260 pM), respectively. Because of their low target concentrations, without enhancers, the sensing performances of these two sensors were studied with 12 cm sensors and 10 min/10 min incubations. These markers were also measured with an NGPR (5 nm nanogold particles-self-assembled monolayers 2 nm in ethanol) by a 6 cm sensor with 5 min/5 min incubations (
Thus, fluorescence can be enhanced by well-designed nanogold particles-self-assembled monolayers, possibly by reducing self-quenching of fluorescence via the strong surface plasmon polaritron fields on the surface of a nanogold particle. This enhancement appears to be dependent on the nanogold particle size, the distance between a fluorophore and a nanogold particle, and the QY of a fluorophore. Some organic solvents also enhance the fluorescence significantly. Some biocompatible solvents, e.g. ethanol, are proven to be an optimal, fluorescence enhancer without affecting the reusability of biosensors. To maximize the enhancement effects NGPRs were developed by combining the nanogold particle-self assembled monolayer and the solvent. Among the NGPRs tested, the 5 nm nanogold particles-self-assembled monolayers at a thickness of 2 nm in ethanol was found to be the best enhancer. The mixture demonstrated an enhancement additive by the nanogold particle-self assembled monolayer and by the solvent. By utilizing NGPRs, accurate quantifications of cardiac markers at tens of picomolar level were achieved, enabling real-time heart attack diagnosis.
While specific embodiments of the present invention have been shown and described, it should be understood that other modifications, substitutions and alternatives are apparent to one of ordinary skill in the art. Such modifications, substitutions and alternatives can be made without departing from the spirit and scope of the invention.
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|Citing Patent
|Filing date
|Publication date
|Jun 21, 2013
|Oct 2, 2013
|Fluorescence type glucose capillary biosensor
|Jun 21, 2013
|Feb 10, 2016
|U.S. Classification
|422/82.08, 436/172, 422/403, 977/777, 977/773, 435/7.1, 422/82.07, 436/525, 422/82.05, 422/82.06, 435/287.2, 435/288.7, 977/904, 422/68.1
|International Classification
|Cooperative Classification
|European Classification
|Oct 21, 2005
Owner name: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
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Matthew McConaughey and his wife Camila Alves looked incredible as they arrived to the 2014 Emmy Awards at the Nokia Theatre L.A. Live in Los Angeles on Aug. 25. The "True Detective" star looked dapper in a blue and black Dolce&Gabbana suit, while Alves wowed in a see-through, white embellished gown by Zuhair Murad.
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Mentioned Characters
Category page
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A category for characters who have not appeared on screen but have been mentioned in the series or by the production staff in relation to the series.
Pages in category "Mentioned Characters"
" Volarik is an unseen character mentioned in the episode "The Mountain and the Viper". He was the...
" Lorimer is a character mentioned in the fifth season episode "High Sparrow". He was a knight for...
" Allana Tyrell is an unseen character in the third season. She is the cousin of Margaery Tyrell...
Allana Tyrell
" Jasper Arryn is an unseen character in Game of Thrones. He is deceased when the events of the...
Jasper Arryn
" Ser Willem Frey is an unseen character mentioned in second and third season. He is a member of...
Willem Frey


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Mashup: Music Favmap
A map of the favorite music of Last.fm listeners. Circles to the right of the map have more plays per listener. The Y axis shows chronology, with the oldest tracks at the top of the chart. The larger the circle, the more plays the artist has received.
Mashups using the same API (830)
A youtube clone with added ability to download the video source from server to PC.
Search Last.fm users and see their location on a map.
A quick and easy way to find movies, watch trailers and share with friends!
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Sound Social with AudioBoo
AudioBoo brings the familiar tape-recorder type interface to the web with all the fixings. Take your audio recording, add a picture, a location, put it in a social context, throw in popularity ratings and you have AudioBoo. The simplicity and social aspects of this service make a great platform for podcasters while providing another avenue of media discovery for users. But it's new and still changing. If you're feeling like an adventurous explorer, ready for twists, turns and surprises, jump on in to the AudioBoo API.
OneMusicAPI Simplifies Music Metadata Collection
Elsten software, digital music organizer, has announced OneMusicAPI. Proclaimed to be "OneMusicAPI to rule them all," the API acts as a music metadata aggregator that pulls from multiple sources across the web through a single interface. Elsten founder and OneMusicAPI creator, Dan Gravell, found keeping pace with constant changes from individual sources became too tedious a process to adequately organize music.
How to Create a Web Application that Visualizes Twitter Updates Over Time API University
As companies, organizations and professionals become more and more interconnected via social networks such as Twitter, LinkedIn and Facebook, a new trend is beginning to emerge—social network data visualization. This article shows you how to make a data visualization of your own.
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|humm is a London based music and video streaming platform with focus on personalization. This service has access to tens of millions of tracks, is advertisement-free, and dedicated to the LATAM...
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Pathfinder Society Scenario #4–16: The Fabric of Reality (PFRPG) PDF
Pathfinder Society Scenario #5–13: Weapon in the Rift (PFRPG) PDF
GM's Miscellany: 20 Things, Volume I (PFRPG) PDF
Pathfinder Module: The Dragon's Demand (PFRPG)
TerraClips: Buildings of Malifaux
Wyrd Miniatures
TerraClips is a 3D, modular terrain system which allows gamers to create expansive, multi-level layouts on-the-fly. Simply punch out the durable components, clip them together using our patent pending TerraClips system, and play! Exquisitely detailed textures created by award winning artists at WorldWorksGames combine to make this one of the most eye catching, easy to use, and flexible terrain system on the market. It is an ideal setting for games of all types and is compatible with all TerraClips products. Mix & match components, stack sewers below, road networks and buildings above.
TerraClips are sold separately, available here.
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Ancient Lands, Eldritch Secrets, and Vast Riches Await in Pathfinder Adventure Card Game: Mummy's Mask,


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This Week in Music History
Take a stroll down memory lane and see what happened this week in music history, June 4th - June 10th.
Take a stroll down memory lane and see what happened this week in music history, June 4th - June 10th.
March 19th, 1974 – Jefferson Airplane re-named the group and became Jefferson Starship. The new line-up included Paul Kantner, Grace Slick, drummer Johnny Barbata, David Freiberg, Peter Kaukonen, Cragi Chaquico and Papa John Creach.
July 18th,1992 - Whitney Houston marries Bobby Brown at her estate right here in New Jersey. Those in attendance included Stevie Wonder, Gloria Estefan, and Patti LaBelle.
August 30th, 1995 – James Taylor and Carly Simon perform together for the first time in over 20 years. They each played their solo set for 10,000 fans before combining acts in Martha's Vineyard, Massachusetts. It was all for a good cause, raising money for a local agricultural society.
July 19th 1975 - Bruce Springsteen and the E Street Band has a marathon rehearsal session the day before kicking off their Born To Run tour. They practiced for a full 19 hours at The Record Plant in New York City to get ready.
May 31st, 1968 - Working on what will become The White album, Yoko Ono attends her first session with The Beatles. Adding overdubs of bass and vocals on 'Revolution', and the final six minutes of the song evolving into chaotic jamming with John Lennon repeatedly shouting "alright" and Yoko speaking random phrases.
March 15th, 1967 - George Harrison records his first session for his new song 'Within You Without You' at Abbey Road. George played the swarmandal and tamboura on this track, and was the only one from the band to perform on this song, which at the time of recording was just called 'Untitled'.
September 1st, 1980 - Fleetwood Mac plays a show at the Hollywood Bowl to end an 18-month world tour promoting 'Tusk', stating on stage that "this is our last show for a long time...
July 19th, 1975 - Bruce Springsteen and the E Street Band has a marathon rehearsal session the day before kicking off their Born To Run tour...
September 22nd
1958 - Elvis Presley gives one last press conference in Brooklyn at the Military Ocean Terminal, with special permission from the Army. He then joined the rest of the 3rd Armored Division on the USS General Randall for a voyage to Bremerhaven, Germany.


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With the growth in the number of smartphones in the market, mobile phone insurance services are expected to take off at an elevated speed. Insurance makes for a major chunk of the mobile ecosystem. It is proj…
This new report provides marketing strategies of global flavor and fragrance companies. The analysis presents:
- Sales force in the U.S. and other international markets.
- Major sale office locations.
- Distribution strategies.
- Major promotional tactics.
The companies analyzed in the report: Firmenich, Givaudan, T. Hasegawa, IFF, Mane, Quest, Robertet, Sensient, Symrise, and Takasago.


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Pile of strawberries, close-up
Credit: Justin Lightley
Creative #: sb10065694ai-001
License type: Royalty-freeRoyalty-free pricing is based solely on the size of the product you need, not the specific use. You don't have to pay any additional royalties on a use-by-use basis. Once you license a royalty-free product, you may use it multiple times for multiple projects without paying additional fees. (Pornographic, defamatory, libelous or otherwise unlawful use of any image is, of course, prohibited.)
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|By PR Newswire
Article Rating:
|February 14, 2013 11:00 AM EST
SOUTH SAN FRANCISCO, Calif., Feb. 14, 2013 /PRNewswire/ -- SuccessFactors, an SAP AG (NYSE: SAP) company and leader in cloud-based business execution software, today announced several key updates to its leading HR portfolio, SuccessFactors' Business Execution (BizX) Suite. With these updates, SuccessFactors and SAP are creating an unmatched comprehensive human capital management (HCM) solution by leveraging the cloud and talent management DNA of SuccessFactors to drive global HR efficiency and empower employees to manage their careers.
(Logo: http://photos.prnewswire.com/prnh/20120216/SF54674LOGO)
The Latest Updates
- New Capabilities for SuccessFactors Employee Central
- SuccessFactors Employee Central continues to expand its global capabilities in 12 new countries, with Cloud Payroll available for 20 countries. With these new features, SuccessFactors Employee Central strengthens its position as one of the most "glocalized" cloud core HR solutions for today's businesses, providing an intuitive user experience and global efficiency fine-tuned to help meet local needs.
- Additionally, for SAP customers, an add-on for integration of SuccessFactors Employee Central integration to SAP® Business Suite software for employee mini-master data integration, including Cloud Payroll, is generally available. This package integrates employee, job, work contract and payroll data between SuccessFactors Employee Central and the enterprise resource planning (ERP) application SAP® ERP.
- SAP® Jam Social Software Platform Adds Expert Mentoring, Forums and Improved Content Creation Capabilities
- Expert mentoring provides support and guidance to help shorten learning curves, expand subject matter expertise quickly and develop future leaders. Employees can invite a broad group of mentees to a single group while creating private folders for each mentee to deliver one-on-one coaching, post documents and create or share videos.
- New forum capabilities capture the collective wisdom of the group and turn ideas into results. This feature helps foster employee and partner innovation, drive interactions and feedback on new HR programs or benefits and highlight subject matter experts who can deliver key insight to the organization. Additionally, internal and external participants can post questions and answers, as well as share, discuss and rank ideas.
- Enhanced document management capabilities increase the velocity of content creation and compliance for HR strategy development, new program planning and communications and building cross-division summary reports for management, with built-in editing, folder URLs and controls for content monitoring and usage.
- Extended Features for BizX Suite
- Updates to SuccessFactors Learning eases learning planning and administration with a new training and budgeting planner while adding flexibility with e-commerce subscriptions that allow customers to offer its users learning bundles at a fixed price for a given period of time. Better support for learning on-the-go is now included with exams enabled for iPad.
- Updates to SuccessFactors Succession increases visibility into existing talent pools and identifies potential gaps with new out-of-the-box Succession Dashboards, which include the customizable ad hoc report builder. An expanded position management framework adds custom fields for staffing requirements, effective-dated historical views for future planning and more precise permission controls for outlining employee responsibilities.
- New features to the SuccessFactors Compensation solution simplify the process by enabling customers to optimize budgets and add flexibility to administration with the new ability to bulk print compensation statements and tailor printing for certain geographies or to run as separate files.
- Now available for all customers, SuccessFactors Workforce Analytics helps improve decision-making with SuccessFactors Headlines, a tool that pushes custom workforce insights to non-technical HR and business managers, providing real-time insight into the performance of their workforce.
For more information on this product release update, visit SuccessFactors.com.
It's Time to Love Work Again.
Follow us: http://twitter.com/SuccessFactors
Like SuccessFactors on Facebook: http://facebook.com/SuccessFactors
Media Contacts:
Rachel Leamon, +1 (617) 912-5411, [email protected], EST
Bri Vorse, +1 (650) 425-0278, [email protected], PST
SOURCE SuccessFactors, Inc.
"We work in the area of Big Data analytics and Big Data analytics is a very crowded space - you have Hadoop, ETL, warehousing, visualization and there's a lot of effort trying to get these tools to talk to each other," explained Mukund Deshpande, head of the Analytics practice at Accelerite, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
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Cloud Expo, Inc. has announced today that Andi Mann returns to 'DevOps at Cloud Expo 2016' as Conference Chair The @DevOpsSummit at Cloud Expo will take place on November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. "DevOps is set to be one of the most profound disruptions to hit IT in decades," said Andi Mann. "It is a natural extension of cloud computing, and I have seen both firsthand and in independent research the fantastic results DevOps delivers. So I am excited t...
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IoT offers a value of almost $4 trillion to the manufacturing industry through platforms that can improve margins, optimize operations & drive high performance work teams. By using IoT technologies as a foundation, manufacturing customers are integrating worker safety with manufacturing systems, driving deep collaboration and utilizing analytics to exponentially increased per-unit margins. However, as Benoit Lheureux, the VP for Research at Gartner points out, "IoT project implementers often ...
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Unless your company can spend a lot of money on new technology, re-engineering your environment and hiring a comprehensive cybersecurity team, you will most likely move to the cloud or seek external service partnerships. In his session at 18th Cloud Expo, Darren Guccione, CEO of Keeper Security, revealed what you need to know when it comes to encryption in the cloud.
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Edge Hosting has announced a partnership with and the availability of CloudFlare, a web application firewall, CDN and DDoS mitigation service. "This partnership enhances Edge Hosting's world class, perimeter layer, application (layer 7) defensive mechanism," said Mark Houpt, Edge Hosting CISO. "The goal was to enable a new layer of customer controlled defense and compliance through the application of DDoS filters and mitigations, the web application firewall (WAF) feature and the added benefit ...
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"SpeedyCloud's specialty lies in providing cloud services - we provide IaaS for Internet and enterprises companies," explained Hao Yu, CEO and co-founder of SpeedyCloud, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
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[session] Redis Functions and Data Structures By @DaveNielsen | @CloudExpo #Cloud #Redis #Containers
Redis is not only the fastest database, but it is the most popular among the new wave of databases running in containers. Redis speeds up just about every data interaction between your users or operational systems. In his session at 19th Cloud Expo, Dave Nielsen, Developer Advocate, Redis Labs, will share the functions and data structures used to solve everyday use cases that are driving Redis' popularity.
Jun. 30, 2016 06:15 PM EDT Reads: 420
Your business relies on your applications and your employees to stay in business. Whether you develop apps or manage business critical apps that help fuel your business, what happens when users experience sluggish performance? You and all technical teams across the organization – application, network, operations, among others, as well as, those outside the organization, like ISPs and third-party providers – are called in to solve the problem.
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Creating replica copies to tolerate a certain number of failures is easy, but very expensive at cloud-scale. Conventional RAID has lower overhead, but it is limited in the number of failures it can tolerate. And the management is like herding cats (overseeing capacity, rebuilds, migrations, and degraded performance). Download Slide Deck: ▸ Here In his general session at 18th Cloud Expo, Scott Cleland, Senior Director of Product Marketing for the HGST Cloud Infrastructure Business Unit, discusse...
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Machine Learning helps make complex systems more efficient. By applying advanced Machine Learning techniques such as Cognitive Fingerprinting, wind project operators can utilize these tools to learn from collected data, detect regular patterns, and optimize their own operations. In his session at 18th Cloud Expo, Stuart Gillen, Director of Business Development at SparkCognition, discussed how research has demonstrated the value of Machine Learning in delivering next generation analytics to imp...
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It's easy to assume that your app will run on a fast and reliable network. The reality for your app's users, though, is often a slow, unreliable network with spotty coverage. What happens when the network doesn't work, or when the device is in airplane mode? You get unhappy, frustrated users. An offline-first app is an app that works, without error, when there is no network connection. In his session at 18th Cloud Expo, Bradley Holt, a Developer Advocate with IBM Cloud Data Services, discussed...
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The cloud promises new levels of agility and cost-savings for Big Data, data warehousing and analytics. But it's challenging to understand all the options – from IaaS and PaaS to newer services like HaaS (Hadoop as a Service) and BDaaS (Big Data as a Service). In her session at @BigDataExpo at @ThingsExpo, Hannah Smalltree, a director at Cazena, provided an educational overview of emerging "as-a-service" options for Big Data in the cloud. This is critical background for IT and data profession...
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"Tintri was started in 2008 with the express purpose of building a storage appliance that is ideal for virtualized environments. We support a lot of different hypervisor platforms from VMware to OpenStack to Hyper-V," explained Dan Florea, Director of Product Management at Tintri, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
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In the world of DevOps there are 'known good practices' – aka 'patterns' – and 'known bad practices' – aka 'anti-patterns.' Many of these patterns and anti-patterns have been developed from real world experience, especially by the early adopters of DevOps theory; but many are more feasible in theory than in practice, especially for more recent entrants to the DevOps scene. In this power panel at @DevOpsSummit at 18th Cloud Expo, moderated by DevOps Conference Chair Andi Mann, panelists discusse...
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A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
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Connected devices and the industrial internet are growing exponentially every year with Cisco expecting 50 billion devices to be in operation by 2020. In this period of growth, location-based insights are becoming invaluable to many businesses as they adopt new connected technologies. Knowing when and where these devices connect from is critical for a number of scenarios in supply chain management, disaster management, emergency response, M2M, location marketing and more. In his session at @Th...
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As organizations shift towards IT-as-a-service models, the need for managing and protecting data residing across physical, virtual, and now cloud environments grows with it. Commvault can ensure protection, access and E-Discovery of your data – whether in a private cloud, a Service Provider delivered public cloud, or a hybrid cloud environment – across the heterogeneous enterprise. In his general session at 18th Cloud Expo, Randy De Meno, Chief Technologist - Windows Products and Microsoft Part...
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What does it look like when you have access to cloud infrastructure and platform under the same roof? Let's talk about the different layers of Technology as a Service: who cares, what runs where, and how does it all fit together. In his session at 18th Cloud Expo, Phil Jackson, Lead Technology Evangelist at SoftLayer, an IBM company, spoke about the picture being painted by IBM Cloud and how the tools being crafted can help fill the gaps in your IT infrastructure.
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In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, provided an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life sett...
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University of Colorado Athletics has selected FORTRUST, Colorado's only Tier III Gold certified data center, as their official data center and colocation services provider, FORTRUST announced today. A nationally recognized and prominent collegiate athletics program, CU provides a high quality and comprehensive student-athlete experience. The program sponsors 17 varsity teams and in their history, the Colorado Buffaloes have collected an impressive 28 national championships. Maintaining uptime...
Jun. 30, 2016 11:45 AM EDT Reads: 851


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Digital Devil Saga: Avatar Tuner 2 is due out in Japan early next year, while the first game is currently on track for a November 16th release locally.
Darksiders II June 26 • 9:00am PDT/12:00pm EDT
Wild Arms 2 July 3 • 9:00am PDT/12:00pm EDT
Lunar 2: Eternal Blue Continues! Every Monday • 5:00pm PDT/8:00pm EDT
Grandia II Continues! Every Wednesday • 2:00pm PDT/5:00pm EDT


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Obama to replace coin robber took from 94-year-old park ranger
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Official: Trooper who slammed suspect acted appropriately
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The NRA's top 11 reimagined classic children's stories
The world of make-believe can be a scary place, but never fear: Thanks to a series of reimagined fairy tales published online by the National Rifle Association, classic characters like Hansel and …
Campus (DILDO) Carry: Texas phallic symbol showdown
LinHad I a million dollars enough, and time, I would, right now, be donating a whole lot of sex toys to college students in Texas. Were I the CEO of an adult toy company – or even one of the Bay …
What color is your domestic violence?
Say what you will about the Salvation Army and its imperfect reputation (anti-gay, conservative, reputed to have not exactly the most sound business practices) but they do know one thing: how to …
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You and your wretched cartoon god
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Scared white guys spur Black Friday gun sales to record high
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Basel head coach Murat Yakin has played down the likelihood of starting an attacking quartet against Schalke on Tuesday.
Yakin surprisingly selected Marco Streller up front alongside Giovanni Sio with goalscoring wingers Mohamed Salah and Valentin Stocker out wide in Basel's 2-1 win away to Chelsea on the opening matchday of the UEFA Champions League.
But despite his team's success at Stamford Bridge, Yakin has not started the same front four in Basel's three league games since the win over Chelsea and the 39-year-old coach remained non-committal about the prospect when asked on Monday.
"It was maybe a surprise that we played with four attackers against Chelsea," Yakin said.
"We will have to see if this is possible tomorrow as some of them have minor knocks, nothing serious, but we will decide tomorrow if the same line-up is possible or if we have to change.
"The players have to be at their best, week after week and that has its effects on their physical condition."
Both Stocker and Salah scored in Basel's 2-2 draw at home against Sion on Saturday.
It was the third straight game that Stocker had scored with the 24-year-old left winger having scored four goals and produced six assists in 13 matches for Basel this season.
Yakin added young defender Fabian Schar will be tested the morning of their match against Schalke.
Schar injured his knee against Sion but trained on Monday.
"He (Schar) will be tested tomorrow morning and we will decide if he can play," Yakin said.
|Y. Sommer
|B. Safari
|K. Voser
|I. Ivanov
|F. Schär
|V. Stocker
|M. Díaz
|F. Frei
|T. Xhaka
|Mohamed Salah
|M. Streller
|Coach: M. Yakin
|T. Hildebrand
|A. Uchida
|B. Höwedes
|Felipe Santana
|R. Neustädter
|D. Aogo
|M. Höger
|J. Draxler
|M. Meyer
|K. Boateng
|J. Farfán
|Coach: J. Keller
for T. Xhaka 62'
for F. Frei 84'
for B. Safari 84'
for J. Farfán 45'
for D. Aogo 78'
for M. Meyer 85'
|Skrtel pins blame on friend after Klopp ´d***´ slur
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|Mascherano set for Barca stay
|Carragher suggests Klinsmann as England boss, dismisses Shearer
|Glik confirms Monaco move
|Australia to face Japan in Melbourne
|Galliani: Montella gives Milan a fresh start
|We must take care of Messi - Argentina president
|England players ´babies´ and soft - Carragher
|Higuain unlikely to renew Napoli contract - agent
|Hart: Tough job for next England boss
|Nani to join Valencia, confirms Fener president
|Glenn: Man, woman or caretaker for England
|Skrtel´s Fenerbahce move ´almost done´
|Al Ahly 1 ASEC Mimosas 2: Jol´s men beaten again
|Hodgson a familiar, sad sight after England collapse in a Heep
|Euro 2016 Diary: Big, bad Barzagli´s bath and Iceland Twitter chills are multiplying
|AC Milan appoint Montella
|St Patrick´s triumph as Europa League kicks off
|TNS claim narrow Champions League qualifying advantage
|Rooney denies players lost faith in Hodgson
|Valdano: Messi retirement no surprise
|Hodgson rejects claims England is impossible job
|Roma´s Doumbia joins Basel on loan
|Glenn seeks cure for ´brittle´ England
|Dembele signing kicks off Rodgers´ Celtic recruitment
|Martial scout departs Monaco
|President: Pato could return to Corinthians
|Elia agrees extended Feyenoord stay
|Inter president: We believe in Mancini
|Hodgson farewell: I don´t know why I´m here
|PSG gamble on Emery in Champions League quest
|PSG confirm Emery will replace Blanc
|Genoa appoint Juric as coach
|England were a racehorse without a jockey under Hodgson - Hill
|Martino to stay on for Argentina´s Olympic campaign
|Inter want Berardi, Candreva and Gabriel Jesus - Thohir
|Ronaldo to best Lewandowski, Italy curse to strike again: The Euro 2016 quarter-finals predicted
|Villarreal hand contract extensions to Rukavina, Bonera
|Wilmots: Hazard will recover in time for Wales
|Sampaoli looking forward to leading passionate Sevilla
|Manchester United improve Mkhitaryan offer
|Poland v Portugal: Nani refutes Greece comparisons
|Alves: Messi must ignore critics after Copa loss
|Sevilla lose Emery, but gain an identity with Sampaoli
|Candreva has preferred club in mind - agent
|Liverpool complete Mane signing
|Italy are better than in 2012 - Low
|Maradona the poster boy but Gerland, Genesio sacred in Lyon
|Alves would be ´honoured´ if Mascherano joined Juventus
|Argentina cannot let Messi retire - Ruggeri
|Stoichkov makes Messi plea
|Alves aiming to bring Champions League to Juventus
|Redknapp has no faith in FA to appoint Hodgson successor
|Sampaoli is a born winner - Sevilla president
|Iceland loss one of England´s darkest days - Hill
|Iceland loss one of England´s darkest days - Hill
|´Scandalous´ that Busquets is never considered for Ballon d´Or - Xavi
|´Scandalous´ that Busquets is never considered for Ballon d´Or - Xavi
|Emery bids farewell to Sevilla
|Messi will pick himself up from Argentina woe - Pique
|Vrsaljko´s Atletico move set to be confirmed
|Berardi wants game time - Di Francesco
|Giaccherini hails Conte: We prepared for tiniest details
|Shearer puts his hand up for England job
|Juventus ´hard to beat´ because of finances - Napoli president
|Nainggolan ´very happy´ at Roma amid Chelsea links
|Maradona calls on Messi to continue with Argentina
|Europe ´vastly underrated´ Italy - Buffon
|Iniesta: Spain were too focused on Italy
|Spain not up to required level - Pique
|Hallgrimsson: Quick equaliser rocked England
|Rooney intends to continue with England
|Apologetic Hart ´devastated´ by Iceland defeat
|Hodgson had to go after humiliating England exit
|´It is embarrassing to go out´ - Rooney
|England pathetic and disgraceful - the world reacts to Hodgson departure
|Lagerback lauds Hodgson after Iceland stun England
|Roy Hodgson´s England career in numbers
|Hodgson resigns: Five contenders to replace him as England boss
|Chiellini delighted to end Italy´s Spain pain
|Alderweireld wary of Wales and Bale


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Analyst lowers capital spending forecast for '05
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A slight pause in the semiconductor industry prompted a research firm to increase its capital spending forecast for 2004 while lowering its outlook for 2005.
Programmability an increasingly viable option for analog
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Observers of Programmable Analog as a business option may take heart in the announcement this week by Anadigm, Inc. that a Canadian recreational boat company, Teleflex, is using Anadigm's parts for steering controls. Steve Ohr filed this report.
Corrigan says chip industry in 'wait-and-see' mode
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The semiconductor industry has adopted a "wait-and-see" attitude marked by vast uncertainties over the direction of oil prices, instability in Iraq and the presidential election, LSI Logic Chairman and Chief Executive Wilfred Corrigan said. Brian Fuller did this interview.
Epson first to sample mobile video interface bridge chip
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Intel seen at lower end of Q3 guidance, says report
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Faced with excess inventories and slow notebook PC sales in the market, Intel Corp. is expected to be at the lower end of its previous guidance for the third quarter of 2004, according to a report from SG Cowen Securities Corp.
At Your Own Trace
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Training sessions combine conference calls with hands on labs and instructionals.
The Rocket Has Left The Building
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Industry's first FPGAs with production-quality transceivers at speeds above 3.7 Gbps.
At The 90 Yard Line, Pass or Punt
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Many go into production with FPGAs on board. But, many look for a lower cost high volume solution. Here's one.
The Right Tools for the Right Jobs
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New Suite of Tools is Setting Standards Everyone Wants to Be a Part of.
Flagship Tool Suite for Electrical Systems Design Is Focus of FPGA Makers
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When industry leaders make significant announcements, everyone wants to get on the bandwagon.
In Silicon We Trust
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For the most part, we all trust in the reliability of our semiconductor devices. This book addresses the soft error issues that can corrupt systems that otherwise function perfectly.
Servered The Way You Like It
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New standards are addressing the server memory issues which presently may be bottlenecking your attainable performance.
On The Cusp
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One thing you can bet on with a reasonable level of confidence. That is that communications will not go away. Our societies and planet are 'wired', physically, or wirelessly.
NOR Shall We Flash
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Are the days numbered for NOR Flash architectures? I think they will always be around, but, NAND Flash is making inroads at eliminating NOR altogether in som applications.
Soft Error Issues Become Sources of Increased Concern
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It is wise to know the enemy. Soft errors are that special class of enemy that can cause perfectly functioning devices to go astray.
NAND Flash Begins Chipping Awaw at NOR Flash Foothold
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NAND Flash has distinct advantages over NOR, but, also carries with it some issues.
Precision voltage reference helps applications eliminate effects of initial accuracy change
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Intersil announces the 1.25 V and 2.5 V power precision voltage references. The design can operate continuously biased so battery powered data acquisition circuits that normally disable the reference between conversions, can now provide high accuracy.
DSP-based fiber optic gyro comes in two configurations
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KVH Industries, Inc.'s new DSP-4000 series fiber optic gyro (FOG) comes in both single- and dual-axis configurations. They are specifically designed to provide the military with a high-performance, low-cost successor to mechanical gyros, according to KVH.
Memec to distribute PLX's PCI, PCI-X products
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PLX Technology Inc. (Sunnyvale, Calif.) and Memec Unique, a division of the Memec Group (San Diego) have announced a distribution agreement for PLX's lines of advanced PCI and PCI-X bridging silicon.
Op amp with unity-gain stability and low noise zips along at 1GHz
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The Analog Devices AD8045 operational amplifier combines a voltage-feedback architecture, unity-gain stability, and a pin-out optimized for high-performance systems. Not bad, but there's more. It provides 1-GHz speed, low noise, and low distortion as well. It makes the op amp a good fit for medical instrumentation, ATE, and data-acquisition systems.
High availability systems save power, space with this diode-OR controller
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The Linear Technology LTC4354 -48V diode-OR controller supports high availability systems and dramatically improves efficiency and eliminates bulky heat sinks with its design that controls external N-channel MOSFETs for the redundant supply paths instead of traditional ORing diodes.
Clock generator is dead-on for xDSL equipment needing low-jitter outputs
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Maxim Integrated Products introduces the MAX9486 clock generator with an 8kHz reference-clock input. The 9486 is a timing solution for ADSL/VDSL central-office line cards and telecom network systems.
Fast POLs meet VRM10 specs
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Artesyn Technology's new VRM10 series of point-of-load (POL) DC/DC converters, for meeting the core requirements of latest-generation processors and fast switching logic, offer up to 85 amps at 1.4 volts and a raw transient response of up to 930 amps/microsecond. The open-frame, single-board series includes the VRM10-80-12-P, with a maximum continuous current rating of 80 amps, and a load-line impedance of 1.24 milliohms (maintaining load regulation to 1.24 mV/A) for Pentium 4 processors. The VR
Cisco invests in chip maker Equator Technologies
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Equator Technologies Inc. said that Cisco Systems Inc. has invested in the supplier of multimedia processors.
Intel tips new strained silicon in 65-nm process technology
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Intel Corp. on Monday (August 30) disclosed more details about its 65-nm process, including an enhancement to its strained-silicon technology.
Ultrasound innards determine IC choices
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There are major trade-offs to be considered when designing ultrasound front-end ICs, writes an Analog Devices engineer. Performance parameters in the ICs affect diagnostic performance and, conversely, system configuration and objectives affect the choice of components. It is essential for designers to understand these trade-offs, he says.
Wireless tech allies with low-power gear
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Ultralow-power radio-frequency technologies are spurring the development of innovative medical tools, from "camera capsules" that can be swallowed to implanted devices that wirelessly transmit patient data. A Zarlink engineer gives details.
New DSPs aid noninvasive diagnostics
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Innovative DSP architectures are fostering the development of advanced medical diagnostic and monitoring equipment that simply was not possible even a few years ago.
Chips analyze the human body
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The application of fundamental semiconductor technologies to medicine, whether in the form of microarrays, microfluidics or neuro chips, is yielding tangible products, writes Junko Yoshida in an introductioh to an EE Times article package on medical electronics. She cites a report that says, as with automotive, semiconductor electronics are seen as the magic which saves the increasingly pressured health care industry.
Ericsson pulls plug on Bluetooth team
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SMIC launches high-voltage process for LCD drivers
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More insights: Analyst still says hold
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Doug Freedman of American Technology Research listened carefully to Semtech, a player in the market for Pentium VRM components. He saw a 53 percent revenue growth over the past year, but worries that the shrinking book-to-bill ratio is a sign for the coming quarter. He still has some favorites in the analog camp.
-48 V diode-OR controller saves power
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Linear Technology's LTC4354 is a -48 volt diode-OR controller chip for high availability systems. It meets the requirements of the AdvancedTCA telecom spec. With the LTC4354, users control two external N-channel MOSFETs in the redundant supply paths instead of traditional OR-ing diodes (which have a higher voltage drop) to dramatically improve efficiency and eliminate bulky heat sinks. The IC is available in a 2-by-3 mm DFN package.
IBM adds immersion lithography to IC roadmap
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Preparing for the next wave of devices, IBM Corp. has quietly added immersion lithography to its chip-manufacturing roadmap.
Hynix moving ahead with chip spin-off despite dissent
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Hynix Semiconductor Inc. is moving ahead with the sale of its non-memory unit "despite the government's rejection to slash stock buyback prices for its dissenting shareholders," according to a report from the
Korea Times.
The Week in Review: August 22 to 28
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Gathered below are the top five stories for the week beginning Sunday August 22, 2004, as ranked by
Silicon Strategies'
readers, up to and including Thursday August 26. The ranking is based on the number of reader "views" or "hits" on a particular article.
Will the real offset voltage please stand up
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Input offsets are composed of a lot more than the initial offset specified on the data sheet. There's also a drift with temperature, a drift with supply voltage, and more. How seriously should you take them? It depends on whether you are building toys or airplanes, says Bill Klein.
Samsung exec sees spot DRAM shortages
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Seasonal PC and cell-phone demand is expected to cause spot DRAM shortages in the second half of 2004, according to an executive from Samsung Electronics Co. Ltd.
ASML, Novellus see chip slowdown, order pushouts
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Front-end equipment vendors are beginning to see new and dreaded order delays in the marketplace amid a lull in capital spending.
Freescale reportedly to increase Taiwan outsourcing
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151 Freescale Semiconductor Inc. (Austin, Tx.) said Friday it would sub-contract more manufacturing to Taiwan companies and maintain its capital spending ratio, according to a
High availability systems save power, space with this diode-OR controller
Product News
Post a comment
The Linear Technology LTC4354 -48V diode-OR controller supports high availability systems and dramatically improves efficiency and eliminates bulky heat sinks with its design that controls external N-channel MOSFETs for the redundant supply paths instead of traditional ORing diodes.
Op amp with unity-gain stability and low noise zips along at 1GHz
Product News
Post a comment
The Analog Devices AD8045 operational amplifier combines a voltage-feedback architecture, unity-gain stability, and a pin-out optimized for high-performance systems. Not bad, but there's more. It provides 1-GHz speed, low noise, and low distortion as well. It makes the op amp a good fit for medical instrumentation, ATE, and data-acquisition systems.
Laser driver optimized for blue common-cathode laser diodes
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The laser driver IC-WKM from IC-Haus is optimized for M-type laser diodes (common cathode) and permits safe continuous wave operation, particularly with blue laser diodes, from a single supply with the laser diode case grounded. It features current capacity up to 350 mA and a supply voltage range up to 15 V.
Intel rolls out trimode version of Centrino
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Intel Corp. rolled out its new and long-awaited Centrino mobile microprocessor, equipped with a tri-mode, Wi-Fi capability.
DRAM Bulletin: spot-market price rally to be short lived
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Despite a rise in prices on the U.S. spot memory market this week and several positive developments regarding DRAM demand, the present rally is doomed to be short lived, iSuppli Corp. believes.
Analog ASSP chip market to grow 27% in 2004
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The market is ripe for application specific analog devices, according to a report from research house Databeans Inc.
China's consumer electronic industry to hit $94 billion
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China's consumer electronics sector is projected to reach $49.6 billion in sales this year, growing by more than 20 percent annually to reach $94 billion in 2007 according to a report.
Gartner modifie légèrement ses prévisions 2004 pour le marché des circuits intégrés
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En dépit dune correction des stocks sur le marché des semi-conducteurs, Gartner Inc. modifie légèrement ses prévisions 2004 concernant le marché des circuits intégrés.
IBM, ASML investigate immersion litho at Albany NanoTech
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Research organization Albany NanoTech on Thursday (August 25) said that it has begun processing 300-mm wafers using the world's first 193-nm "pre-production" immersion lithography system from ASML Holding NV of the Netherlands.
Precision voltage reference helps applications eliminate effects of initial accuracy change
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Intersil announces the 1.25 V and 2.5 V power precision voltage references. The design can operate continuously biased so battery powered data acquisition circuits that normally disable the reference between conversions, can now provide high accuracy.
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I'm thinking Max & the other people who grew up in the British Isles need a "Wankers Corners" T shirt. Bill
I'm thinking Max & the other people who grew up in the British Isles need a "Wankers Corners" T shirt. Bill
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Ariana Grande's 'One Last Time' Gets the 1985 TreatmentThis remix of can hang with Belinda Carlisle and Taylor Dane any time.
Demi Lovato Went on a Mariah Carey Rant Last NightLovato was defending Ariana Grande, the subject of an unflattering comparison to Carey.
Ariana Grande Celebrates Marilyn Monroe's 90th BirthdayThe singer post two clips of the actress on her Instagram account this afternoon.
Ariana Grande Drops Sexy 'Into You' VideoThe new clip was directed by Hannah Lux Davis who also directed Grande's video for "Focus."
Ariana Grande Teases Horror Movie Spoof 'Dogface Filter'The star debuted a trailer for a side project you probably haven't heard of: the upcoming "Snapchat movie," Dogface Filter.
Ariana Grande's 'Dangerous Woman' Gets Rapturous ReactionFollowing a long, slow rollout, Ariana Grande's new album 'Dangerous Woman' is finally here, and fans can't get enough.
Impact: Ariana Grande Turns Into a 'Dangerous Woman' with Third AlbumThe Florida singer burst on the scene in 2013 with her debut studio album Yours Truly and hasn't stopped wowing audiences since.
Preview Ariana Grande's 'Dangerous Woman'The project doesn't drop until Friday, but there's plenty of music to listen to.
Watch Ariana Grande Video 'Let Me Love You' Featuring Lil Wayne"Let Me Love You" is the latest song Grande has released from her new album.
Ariana Grande Features Future 'Everyday' on New 'Dangerous Woman' CutIn an unusual, but very effective play, the disney alum turned pop superstar has released five singles from her not-yet released album.
Preview Ariana Grande's New Track 'Greedy'Grande continues to tease new music from her forthcoming album Dangerous Woman.
Ariana Grande Drops New 'Dangerous Woman' Track: 'Into You'The radio-friendly dance track combines pulsating electro beats with Grande's iridescent vocals.