text:
|Publication number
|Publication type
|Publication date
|Aug 14, 1956
|Filing date
|Apr 22, 1953
|Priority date
|Dec 10, 1949
|Publication number
|Stevens Donald G
|Original Assignee
|Standard Oil Co
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (4), Referenced by (65), Classifications (19)
|External Links: USPTO, USPTO Assignment, Espacenet
Aug. 14, 1956 D. e. STEVENS MULTIPLE COMPARTMENT TANK Original Filed Dec. 10 19:19
INVENTOR DONALD G. STEVENS BY xwfl w,
- TTORNEYS United States Patent MULTIPLE CUMPARTMENT TANK Donald G'. Stevens, Solon, Ohio, assignor to The Standard- Oil Company, Cleveland, Ohio, a corporation of Ohio Original application December 10, 1949, Serial No. 132,291. Divided and this application April 22, 1953, Serial No. 350,300
'1 Claim. (Cl. 220- 63) This invention relates to a commodity carrier. More particularly it relates to a tank-type carrier adapted to accommodate at different times and Without an intervening tank cleaning operation any number of full loadings of two different liquids without subjecting. either liquid to contamination by residue of the other.
This application is a division of the copend-ing, application Serial No. 132,291, filed December 10, 1949.
The use of a tank wagon to transport a capacity load of an unrefined stock, such as crude oil, from a storage point to a refinery and then to carry a capacity load of a refined stock, such as gasoline, on the return or other ensuing trip has heretofore required thorough cleaning of the tank after unloading the crude stock to remove all remnants thereof in order to prevent contamination of. the refined product. Where effective purging operations cannot be readily or economically performed, it has been necessary to allocate one tank wagon for each product transported, resulting in non-productive return trips with an empty tank.
Two different species of an invention for overcoming the economic disadvantages of conventional tank wagons are disclosed in the said copending application. In one species a flexible single-sheet diaphragm is attached girthwise to the walls of a horizontally disposed cylindrical tank approximately midway between the ends. Suflicient slack is provided to enable the diaphragm to be forced to one end of the tank or the other. With separate sets of inlet and outlet openings provided in the tank on both sides of the diaphragm, the tank may be filled to capacity and emptied at different times with incompatible liquids without cross contamination.
By the use of this arrangement, however, regardless of which way the tank is filled, a portion of the bare walls of the tank as well as one surface of the flexible diaphragm are necessarily engaged by the liquid, making it necessary to limit the use of the tank to fluids which will not harm the walls of the tank, or alternatively to coat the inside walls of the tank with a protective barrier.
Another disadvantage of the aforedescri bed arrangement is that the attachment of a diaphragm girthwise within a cylindrical tank necessitates the use of an elaborate joint construction to effect a liquid-tight, mechanically strong seal. Most existing tanks are not readily adapted to such diaphragm installation in the absence of structural modifications. For example, one means for attaching the diaphragm requires the use of a two-part tank construction, the diaphragm being clamped therebetween. A still further disadvantage resides in the fact that the inherent partitioning nature of the diaphragm requires a more or less symmetrical tank as well as a mounting for the diaphragm which bisects the tank. Moreover there are further limitations imposed on the location of the bisecting diaphragm so as to avoid the creation of undrainable pockets for liquid within the tank.
It is therefore one object of the species of the invention of this application to provide an improved tank construction whereby the same tank may be filled to capacity at 2,758,747 Patentedv Aug. 14, 1956- ice 2 different times through different inlets with no possibility of cross contamination and whereby for at least one mode of filling the inside walls of the tank are completely shielded from the liquid, in the absence of additional protective means.
Another object of the invention is to provide an improved tank construction which may be incorporated in tanlcs of a wide variety ot shapes and which may use inlet and outlet connectors disposed at a wide variety of positions on. the tank. Still another object of the invention is to provide an improved design for affording separate filling'areas within a single tank which may be carried out with minimum structural modifications and which may be readily applied to existing tanks of many designs.
These and other objects and features are attained in accordance with the present invention by fitting a liquidti'ght tank, which may be of any Particular sha e, with two sets of inlet and outlet connectors, preferably at the top and bottom, respectively, of the tank. To one set of connectors is attached a bag-type member having, flexible, liquid-tight walls capable of assuming substantially the same shape as the inside of the tank. These connectors communicate with the inside of the bag-type member. In this fashion the tank may be filled to capacity and then drained by means of the first set of connectors, and then filled to capacity and drained by means of the second set of connectors. In the former case the bag type member will completely line the inside walls of the tank so that liquids may be ac'commodated which are harmful to those walls. In the latter case the inside walls of the tank will be engaged directly by the liquid. However, if bothliquids to be accommodated are harmful to the walls of the tank, additional bagdype members,vv each with its own inlet and outlet, may be provided within the tank. In any case, there will be no surfacescommon to both inlets so that residual liquid accommodatedby the first set of connectors will never contaminate liquid accommodated by the second set When the second set of connectors is used, the bag-type members will collapse.
In order to prevent the bag-type member from blocking. the outlet connector of the second set of connectors, a raised, perforate shield may be disposed 'thereover;
The invention may be better understood by reference to the accompanying drawing in which:
Figure 1 is a side view in cross-section of a portion of a tank assembly formed in accordance with present invention; and
Figure 2 is a view corresponding to Figure 1 showing the arrangement of tank parts when the tank is filled to slightly less than capacity through one of the inlet connectors.
In the illustrated embodiment of the invention there is shown a liquid-tight tank 10 which may, if desired, be formed within a shell common to other and like tanks such as the tank 100, the two tanks otherwise being entirely separated by virtue of a liquid-tight barrier 11. A pair of inlet connectors 12 and 13, which may include suitable valves 12' and 13', respectively, are fitted in the tank in the vicinity of its upper end. A pair of outlet connectors 14 and 15, which may include valves 14 and 15, respectively, are fitted in the tank in the vicinity of its lower end.
Contained Within the tank 10 is an imperforate flexible, bag-like member 16 formed of rubber, plastic, treated fabric, or other suitable material and secured to the inlet connector 12 and the outlet connector 14 in liquid-tight joints 17 and 18 so that liquid may be passed in and out of the flexible member 16. When filled to capacity through the inlet connector 12 the flexible member overlays the inner surfaces of the tank and assumes the contours thereof. This liquid can be withdrawn only through the outlet connector 14 and none will ever engage the unprotected walls of the tank. For this reason a liquid may be accommodated to the full capacity of the tank which is harmful to the material to which the rigid walls are formed. Thus, for example, the tank may be formed of metal and, nevertheless, be utilized to accommodate harmful acids by utilizing a flexible member formed of a material suitbaly impervious to the action of the acids.
The tank may also be filled to capacity through the inlet 13, in which case the flexible member 16 will be caused to collapse thereby occupying very little total volume within the tank. The outlet connector 15 is provided for emptying the products taken on through the inet connector 13 and so that it will not become clogged by the flexible bag member, a suitable barrier in the form of a screen or perforate shield 19 offset from the inner surface of the tank is provided.
Because the flexible member 16 prevents any exposure of the inside walls of the tank to the liquids introduced through the inlet connector 12, there is no possibility of contamination of a liquid product taken in through that inlet by remnants of a liquid taken in through inlet 13. It follows that a liquid introduced through the inlet 13 is not subject to contamination by residual liquid previously introduced through this inlet 12.
The tank may, if desired, be filled partially through each of the inlets, with the flexible bag member preventing intermixing. It should be noted that the overall tank assembly may be divided into a multiplicity of tanks within the purview of the invention as by the rigid inner wall or barrier 11 so that a plurality of separate tanks are provided, each of which may be fitted with a flexible member as described above. Also, within the purview of the invention, at least two flexible bag-type members may be used within each tank, one being collapsed Within the tank at such times as the other is filled, or the two being utilized concurrently to accommodate partial loadings of different liquids simultaneously and independently. Each flexible member will of course have its own inlet connector and in no case will the bare inside walls of the tank be engaged by the liquids.
It will be understood that the flexible inner bag member by its collapsing action tends to prevent exposure of liquids stored therein to excessive amounts of air, and consequently prevents vapor losses from volatile liquids.
From the foregoing detailed description of preferred embodiments of the invention it will be apparent that modifications may be made, within the spirit of the invention, to provide tanks formed into compartments by internal bag-type members and accordingly the invention should not be limited to the specific embodiments described above but should be determined in scope by the following claim.
I claim:
A tank assembly adapted to accommodate loadings of non-compatible liquids at separate times, comprising, a liquid-tight tank having at least first and second spaced apart inlet connectors disposed in the vicinity of the top of the tank, at least first and second spaced apart outlet connectors disposed substantially in vertical alignment with said first and second inlet connectors respectively and located in the vicinity of the bottom of the tank, a bag-type container having flexible liquid-tight walls and mounted within the tank to define a closed space therein, said flexible bag-type container having a size and shape, when filled, corresponding substantially to the size and shape of the interior of the tank, and means forming an inlet and an outlet respectively in the top and bottom of the bag-type container and joined respectively to the first inlet and first outlet connectors of the tank in fluid-tight unions, said connections forming the sole securing means of said bag-type container within said tank whereby the tank may be filled through said first inlet connector and drained through the corersponding outlet connector, during which the interior walls of the tank will be shielded throughout from the liquid by menas of the bag-type container, and during which residual liquid in the tank from a preceding loading accommodated by the second inlet and outlet connectors will be unable to contaminate the liquid, and whereby the tank may be filled through the second inlet connector and drained through the corresponding outlet connector, during which the flexible bag-type container will be collapsed on itself to bring its opposite internal surfaces into engagement.
References Cited in the file of this patent UNITED STATES PATENTS 2,316,116 Thompson et a1. Apr. 6, 1943 FOREIGN PATENTS 10,419 Great Britain 1844 251,777 Italy Feb. 2, 1927 932,322 France Nov. 24, 1947
|Cited Patent
|Filing date
|Publication date
|Oct 26, 1939
|Apr 6, 1943
|Case Co J I
|Title not available
|Title not available
|Title not available
|Citing Patent
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|May 31, 1955
|Mar 31, 1959
|Exxon Research Engineering Co
|Apparatus for shipping greases
|Apr 18, 1956
|Feb 16, 1960
|Line Dispensers Inc B
|Piercing and tapping device for fluid filled film containers
|Jan 14, 1957
|Oct 18, 1960
|Wilhelm Hermanns
|Container having a built-in emptying device for pulverulent material or the like
|Aug 19, 1957
|May 16, 1961
|Chr Olsson I Falkenberg Ab
|Cistern or tank for the transport and storing of different liquids
|Apr 28, 1958
|Jun 20, 1961
|Daggitt Deloss E
|Storage container with protective liner
|Oct 28, 1958
|Jul 17, 1962
|Dyer Arthur M
|Apparatus for dispensing measured quantities of liquids
|Jan 12, 1959
|Apr 2, 1963
|Welty Frank
|Apparatus for packaging and dispensing beverages or the like
|Nov 25, 1960
|Dec 3, 1963
|Frederick Bryant
|Bulk fluid transport
|Apr 12, 1957
|Jan 14, 1964
|Hoover Co
|Unitary floor scrubbing and drying appliance
|Aug 8, 1960
|Jan 28, 1964
|Dyer Arthur M
|Apparatus for dispensing measured quantities of liquids
|Apr 27, 1964
|Oct 5, 1965
|Westinghouse Electric Corp
|Control for compacting bag in household appliance
|Jan 24, 1967
|Jan 14, 1969
|Dynabulk Corp
|Material discharging device for containers
|Oct 6, 1966
|Jul 22, 1969
|Dynabulk Corp
|Condensation-deterring container
|Oct 25, 1967
|Feb 17, 1970
|Acf Ind Inc
|Railway hopper car with separate compartments between the hoppers
|Mar 20, 1969
|Jun 8, 1971
|Gen Am Transport
|Convertible multiple compartment hopper-tank car
|Jun 29, 1970
|May 16, 1972
|Sims Samuel Francis
|Device for displacing a substance in response to forces generated by a fluid under pressure
|Dec 20, 1971
|Jul 16, 1974
|North American Car Corp
|Bin type freight car
|Oct 27, 1972
|Sep 2, 1975
|Combustion Eng
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|Dec 6, 1973
|Nov 11, 1975
|Tekko Corp
|Convertible compartment container
|Aug 31, 1976
|Aug 22, 1978
|Claudius Peters Ag And Maxpeters Gesellschaft Fuer Verfahrenstechnik Mbh
|Process and equipment for effecting savings in compressed gases during injection of solids by means of pneumatic conveyors
|Aug 10, 1978
|Nov 20, 1979
|Union Tank Car Company
|Methods for loading and unloading liquids from a railroad tank car
|Aug 10, 1978
|Jul 1, 1980
|Union Tank Car Company
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|Jan 26, 1979
|Jul 21, 1981
|Pursell Grant W
|Dispensing of hygienic fluids
|Oct 13, 1981
|Nov 27, 1984
|David George J
|Method and apparatus for transporting potable water and other fluids
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|Jun 9, 1987
|Reuben Krein
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|Sep 7, 1988
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|Bjk Industries, Inc.
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|Mar 12, 1992
|Oct 26, 1993
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|Sep 6, 1994
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|Isk Biosciences Corporation
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|Collapsible sheath fluid reservoirs for flow cytometers
|Aug 4, 1999
|Aug 27, 2002
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|Mar 16, 1999
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|Apparatus and method for use with a container for storing a substance
|Oct 13, 2005
|Aug 25, 2009
|Ford Global Technologies, Llc
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|Jun 14, 2011
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|Honeywell International Inc.
|Ambient pressure-responsive variable volume fuel tank
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|Han-Chin Lai
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|Full Most Co., Ltd.
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|Oct 12, 2011
|Apr 7, 2015
|Elend S. LeBaron
|Dual bladder system and method for treatment and reduction of microbial content in fluids by means of high pressure
|Jul 29, 2013
|Jun 16, 2015
|Albonair Gmbh
|Reducing agent metering system with metering chamber for exact setting of the metered amount
|Oct 31, 2002
|Jul 3, 2003
|Dodd Peter Jeremy
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|Jan 27, 2003
|Jul 29, 2004
|Inbar-Water Distribution Company Ltd
|Flexible vessel
|Dec 1, 2003
|Aug 12, 2004
|Inbar-Water Distribution Company Ltd
|Flexible vessel
|Nov 11, 2004
|May 11, 2006
|Reed Richard J
|Multi compartment collapsible tank
|Oct 13, 2005
|Apr 19, 2007
|Ford Globall Technologies, Llc
|Freeze protection for on-board vehicle emissions treatment system
|Oct 10, 2007
|Apr 17, 2008
|Hilti Aktiengesellschaft
|Mobile fluid feeding apparatus for a power tool
|May 2, 2007
|Nov 6, 2008
|Martucci Norman S
|Fuel bladder apparatus and method
|Jul 14, 2009
|Nov 5, 2009
|Ford Global Technologies, Llc
|Freeze protection for on-board vehicle emissions treatment system
|Jun 19, 2008
|Dec 24, 2009
|Honeywell International Inc.
|Ambient pressure-responsive variable volume fuel tank
|Jan 10, 2007
|Dec 24, 2009
|Erik Jeroen Eenkhoorn
|Inflatable element for internal use in the container of a transport or storage device; method for inflating the element
|Jan 26, 2012
|Lin I-Hsing
|Foam tank structure improvement
|Dec 9, 2011
|Jun 21, 2012
|Han-Chin Lai
|Hydro-pneumatic pressure vessel
|Oct 12, 2011
|Apr 18, 2013
|Elend S. LeBaron
|Dual bladder system and method for treatment and reduction of microbial content in fluids by means of high pressure
|Feb 15, 2013
|Aug 22, 2013
|Full Most Co., Ltd.
|Gasoline storage device
|Jul 29, 2013
|Feb 6, 2014
|Albonair Gmbh
|Reducing Agent Metering System with Metering Chamber for Exact Setting of the Metered Amount
|May 15, 2012
|Aug 15, 2012
|Garbage sewage tank with built-in flexible water tank
|Mar 14, 1978
|Sep 20, 1979
|Sumitomo Electric Industries
|Oil storage and water tank with dividing membrane - has protective plates mounted across corners to prevent membrane from blocking inlet openings
|May 6, 1985
|Oct 8, 1987
|Wolfram Wittenborn
|Vapour-tight tank for liquids of variable vapour pressure
|Aug 2, 2004
|Mar 16, 2006
|Ducqu�, Ralf
|Fluid e.g. gas, supplying system for use in caravan, has two containers disposed at common movable limiting barrier whose movement leads to reduction of volume of one container and enlargement of volume of another container
|Feb 27, 1998
|Sep 9, 1998
|HET Haller Entwicklungs- und Technologiegesellschaft mbH + Co.
|Fluid container
|Apr 9, 2003
|Oct 15, 2003
|FFG Flensburger Fahrzeugbau Gesellschaft mbH
|Device for the separate receiving and collection of at least two media, in particular for high pressure purge and suction vehicles
|Apr 13, 1981
|Oct 29, 1981
|M Moreau
|Bladder device within tanks
|Apr 11, 1991
|Oct 17, 1991
|Haahjem Eiendom A/S
|A tank arrangement
|Jul 17, 1998
|Jan 28, 1999
|The Regents Of The University Of California
|Collapsible sheath fluid reservoirs for flow cytometers
|Mar 24, 2005
|Oct 6, 2005
|Clers Bertrand Des
|Device for securing the storage, transfer, transport and handling of dangerous, combustible, oxidising, corrosive, toxic and/or contaminant products
|U.S. Classification
|220/530, 222/386.5, 220/62.21, 105/359, 220/723, 105/358, 406/146
|International Classification
|Cooperative Classification
|European Classification


text:
Edenvale News
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The 10 oldest, significant open-source programs
Today, open-source software is everywhere but many peple still think of it as being relatively new. It's not. Open-source software actually goes back decades.
So, with no further adieu, from the most recent to the oldest, here's my list of older significant open-source projects.
1) Linux: August 25, 1991
There were thousands of open-source programs before Linus Torvalds wrote "I'm doing a (free) operating system (just a hobby, won't be big and professional like gnu) for 386(486) AT clones." to the Minix Usenet group and unknowingly started the operating system juggernaut that became Linux. That said, Linux has also become the most successful of open-source programs.
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June, 2005, Vol. 05, Issue 06
An Open Letter to the NCBTMB
By Gregory T. Lawton, DN, DC
The National Certification Board for Therapeutic Massage and Bodywork (NCBTMB) has previously announced its intention to enforce the following criteria in June 2005:
I have attempted to get guidance (as have other school owners) regarding the NCBTMB's position on online (eLearning) supervised classes.Almost every accredited college and university in the United States is providing online classes. This includes medical schools and other health profession training programs; state and professional licensing boards also recognize online training.
Most colleges and universities offer anatomy, physiology, pathology, kinesiology, business, ethics and numerous other courses online, and these classes lead directly to associate's, bachelor's and master's degrees in numerous fields. Generally, the recognized minimum standard for an online class to be considered online, in-class, and supervised, is that 20 percent of the time spent in the online class is with an online teacher.
In Michigan, some massage schools have been pressuring the NCBTMB not to recognize the graduates of certain massage school training programs based on the in-class supervised standard. I expect that come June 2005, there will be a number of complaints directed at the NCBTMB regarding rival schools' curriculum.
I would like to get NCBTMB's (and have been unsuccessful to date) position on exactly what constitutes in-class supervised training. For example, some schools show videos in their classes or may provide a brief lecture followed by one-on-one practice. In a number of examples the instructor does not actually stay in the classroom for the entire class. Is there a percentage of time based on total class time that equals the in-class supervised definition?
My central question is in regard to online classes, which is obviously an important movement in education and will continue to increase in the coming years. Is the NCBTMB position that massage schools, as opposed to every other educational institution in the U.S., cannot provide online education? How does the NCBTMB intend to regulate community colleges and colleges that do and will continue to allow massage students to complete their health science, business, ethics and other lecture courses online, or does the NCBTMB plan on adopting a double standard - one standard for colleges and the other for post-secondary or vocational massage schools?
I have another example that results in confusion regarding the NCBTMB standard. Because my school offers a highly specialized medical massage training program, we attract a large number of medical health professionals, such as physical and occupational therapists and nurses. We provide advanced standing to these graduates of college-based programs, who, in many cases, earned hours in online classes in anatomy, physiology, pathology and other lecture courses. If this is no longer acceptable under the NCBTMB standard it would mean that we would not be able to accept credit hours earned in accredited college-based online programs.
Also on the horizon is the new associate's in occupational studies degree, which will prove to be an exciting new direction for massage schools. Many of the vocational and technical schools that provide access to this new degree program offer online training. Is it the intention of the NCBTMB to dictate to massage schools, colleges and universities, technical and vocational schools, and related governing organizations and associations that they may not include in-class online supervised training to massage students?
If this is the case, I believe that it is time for a pointed dialog between schools, educational and trade associations, and state education and professional licensure departments that have interests in or are involved in providing, overseeing or regulating massage education.
I sincerely invite a response to the questions that I have proposed in this letter regarding online in-class supervised education.
Thank you,
Gregory T. Lawton, DN, DC, Mac
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Video: Pancakes for your face
posted at 8:47 am on January 31, 2008 by Allahpundit
Something for breakfast. Looks more like crepes for your face to me, but we needn't quibble — except perhaps over that first recipe he assembles. Does anyone actually eat pancakes with sugar and … lemon squeezin's? Willingly, I mean?
Breaking on Hot Air
Exercising your right to own firearms now lands you on a federal database in Hawaii
Marilyn Mosby may have an ethical obligation to abandon the rest of the Freddie Gray trials


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About Me
Amy Reynaldo, the author of How to Conquer the New York Times Crossword Puzzle, is a top-10 finisher at the American Crossword Puzzle Tournament. Her first New York Times crossword byline appeared July 5, 2009. She solves at least three crosswords a day and writes about them here.
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The AV Club puzzle this week is a meta contest puzzle by Francis Heaney. It will be reviewed on this site after the contest closes Sunday.
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Woolman Family History & Genealogy
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Events Rundown: March 5-11, 2013
There are lots of folks in town to celebrate the 52nd annual Canadian-American Days Festival, Big South Conference Championships and more. If you're looking for something to do in Myrtle Beach this list will help you get started. Visit our events page for a complete list of things going on.
Big South Conference Championships
Basketball fans can catch plenty of live games in Myrtle Beach during the Big South Conference Championships. Games are scheduled from March 5-10 at the HTC Center. Semi-finals begin at 12 p.m. Saturday, March 9 and the championship game will be played at 12 p.m. Sunday, March 10.
ONE: The New Show
Locals and visitors flock to the Alabama Theatre to see ONE: The New Show year after year. The show offers something for all ages and features new content for 2013. Experience an evening of comedy, song, dance and fun. The costume changes and special effects add an extra flare to each song and dance number. ONE: The New Show will be performed at 7:30 p.m. Monday through Saturday.
Surfside Beach BBQ Festival
The town of Surfside Beach is hosting a BBQ Festival from 10 a.m. to 4 p.m. Saturday, March 9 on Surfside Drive. They'll have free inflatables for the kids, local arts and crafts vendors and of course, lots of yummy food. Sawgrass and the Josh Brannon Band will perform live at the event. Proceeds benefit SAFER.
52nd annual Canadian-American Days Festival
The 52nd annual Canadian-American Days Festival and Celebration will be held from March 9-16. There will be celebrations on the north and south strand, a free concert, expo and more. Click here for a complete list of Can-Am events and celebrations in Myrtle Beach.
Romantic Blockbusters
The Long Bay Symphony presents "Romantic Blockbusters." Sebastian Baverstam will be featured on the cello. Works from Rossini, Saint-Saens and Brahms will be performed. Local composer and CCU faculty member, Donald Sloan, will premiere his brand new commission during the event. The concert will be held at 4 p.m. Sunday, March 10 at the Myrtle Beach High School Music and Arts Center.
Hot Jersey Nights
Hot Jersey Nights is the newest show to hit the Palace Theatre in Myrtle Beach. The show celebrates the music of Frankie Valli and The Four Seasons with performances of "Sherry," "Let's Hang On," "Bye Bye Baby" and many more. The authentic costumes add to the magic of each performance. Hot Jersey Nights will be held at 5:30 p.m. Tuesday through Saturday, 10 a.m. Wednesday and 2 p.m. Tuesday and Thursday.
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|Publication number
|Publication type
|Application number
|Publication date
|Apr 7, 1987
|Filing date
|Jun 12, 1985
|Priority date
|Sep 21, 1979
|Fee status
|Also published as
|Publication number
|Ottorino Fanelli
|Original Assignee
|Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Referenced by (8), Classifications (4), Legal Events (3)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a continuation of co-pending application Ser. No. 558,563, filed on Dec. 5, 1983, which is a continuation of application Ser. No. 187,654, filed on Sept. 16, 1980, both are abandoned.
The present invention concerns a pharmaceutical composition comprising L carnitine for the treatment of cardiac dysfunctions, and likewise concerns a therapeutical method comprising administering such a composition to patients affected by such dysfunctions.
The therapeutical use of carnitine (β-hydroxy-γ-trimethylamino-butyric acid) in the treatment of cardiac arrhythmias and impaired cardiac function associated with congestive heart failure and cardiogenic shock has already been disclosed in U.S. Pat. Nos. 3,830,931 and 3,968,241 issued to De Felice.
It is likewise known the β-hydroxy-γ-trimethyl-amino butyric acid presents an asymmetrical centre and hence occurs in the two stereoisomer forms D and L. In the aforementioned U.S. patents it is taught that ". . . either the racemate or the individual isomers can be employed. While the racemate can be conveniently employed, it appears the L isomer is more active while the D isomer is slightly more toxic". The prior art teaches therefore that, in the treatment of the aforementioned cardiac dysfunctions, the L form and the D form are both active, although a certain preference may be given to the L form versus the D form.
If it is considered that, as is well known, the resolution of a racemate into the respective optical antipodes generally involves complex and expensive processes, as in fact occurs in the case of the separation of L-carnitine from D-carnitine, and that in the aforementioned patents it is affirmed that the racemic form can be suitably employed, it is evident that the prior art as a whole in no way suggests, at least in regard to the aforementioned therapeutical purposes, the separation of the optical antipodes for the employment of L-carnitine alone, but rather to simply use carnitine in its racemic form.
It has now been surprisingly found, and is the presupposition of the present invention, that, conversely to what is taught by the known art, in the treatment of certain cardiac dysfunctions and particularly of those disclosed in the aforementioned patents to De Felice, D-carnitine is not only slightly more toxic than L-carnitine, but even exhibits a true and proper antagonistic effect against the therapeutical properties of L-carnitine. It must be well understood that it has been discovered that the D form is not simply inactive as compared to the L form, that is it does not act as a simple "diluent" of the active L form, but rather it antagonizes, at least partially inhibiting the therapeutically advantageous effect of L-carnitine.
Therefore the object of the present invention is a pharmaceutical composition for the treatment of myocardial anoxia, myocardial ischaemia, arrhythmic syndromes and heart failure, comprising an effective amount of carnitine and characterized by the fact that said carnitine is solely L-carnitine.
For the purpose of the present invention the term "solely L-carnitine" means not only that the component of the composition consisting of carnitine is substantially pure L-carnitine, that is except for eventual impurities or traces of D-carnitine, but also that carnitine, can be "prevailingly" L-carnitine, that is clearly exceeding the quantity of D-carnitine present, for instance by an L:D ratio of 95:5.
It has likewise been found that a pharamecutical composition particularly suitable for the aforementioned therapeutical uses, when in the unit dosage form, comprises from approximately 50 mg to approximately 500 mg of L-carnitine.
Therefore the scope of the present invention also includes a therapeutical method for the treatment of patients affected by myocardial anoxia, myocardial ischaemia, arrhythmic syndromes and heart failure, characterized by the fact of administering to said patients, via the oral or parenteral route, a pharmaceutical composition comprising an effective amount of carnitine present solely in the L form.
Although the daily dose to be administered depends, according to sound professional judgment, upon bodyweight, age, general conditions and the specific affection exhibited by the patient, it has been found that it is generally suitable to administer to said patients from approximately 2 mg/kg to approximately 10 mg/kg of bodyweight per day of L-carnitine.
The antagonistic effect of D-carnitine against L-carnitine has been experimentally demonstrated by means of the following techniques.
Male rabbit hearts weighing 1.6-1.8 kg were isolated as per the method described by O. Fanelli, Life Sciences, 23,2563-2570 (1978).
The hearts were perfused as per the Langendorff method (O.-Langendorff, Pfugers Arch. Ges. Physiol. 61,291-333, (1985) using a Ringer solution (which was not recycled) maintained at 38� C. and at a pressure 54 cm of water bubbled with pure oxygen.
The isometric contractions were recorded by a transducer attached via a pulley to a clip on the apex of the ventricles and regulated in such a manner as to exert a tension force of 4 grammes. By means of another transducer connected to a volume displacement recorder the coronary flow was monitored giving normal values: 22�4 ml/min.
The ECG was monitored using surface electrodes. Only hearts which initially showed a rate of at least 140 beats per minute were used. After a period of acclimatization lasting 25-30 minutes under the aforementioned experimental conditions, the basal values of the hearts to be treated with blank Ringer solution (controls) and standard Ringer solution containing L-carnitine or D-carnitine at the same concentration of 1.105 g/l were recorded for 15 minutes taking care to discard hearts exhibiting some irregularities.
Cardiac stimulation was achieved by injecting 0.5 ml of Ringer solution containing 0.5 mcg of adrenaline using a lateral canula inserted into the aortic bulb. This stimulation was repeated four times at 5-minute intervals.
The stress tolerated by the heart for each injection of adrenaline was calculated by the formula: ##EQU1## where Δg is the increasing tension force (in grammes) and Δf is heart rate (number of beats) during the period of time (in seconds) wherein the increase in tension force occurs.
The values referring to the control hearts were compared to the respective values obtained with the hearts perfused with Ringer solution containing L-carnitine or D-carnitine, using Student's and Cochran-Cox's "t" test.
Cornary flow
The basal values given in Table 1 show that L-carnitine slightly increases coronary flow, whereas D-carnitine does not.
Conversely, when adrenaline is injected D-carnitine increases the coronary-dilator effect of adrenaline, whereas L-carnitine reduces it.
Tension force peak
The data given in Table 2 show that adrenaline-induced tension force peak is decreased by L-carnitine, while D-carnitine practically does not modify it.
Duration of increased tension force induced by adrenaline
The data given in Table 3 show that the duration of increased tension force induced by adrenaline is shortened by L-carnitine, whereas D-carnitine lengthens it.
Heart rate
The data given in Table 4 show that adrenaline-induced tachycardia is reduced by L-carnitine and increased by D-carnitine.
Stress effect
The data given in Table 5 show that the stress effect is decreased by L-carnitine, whereas D-carnitine increases it.
Examination of the stress index (FIG. 1) shows that L-carnitine has an antagonizing effect on adrenaline-induced stress, while D-carnitine enhances it.
From the above experimental results it appears evident that L-carnitine reduces the three effects of stimulation on the heart exerted by adrenaline (see Tables 2,3 and 4), whereas D-carnitine even heightens the adrenaline effect on the duration of tension force and heart rate. Consequently (see Table 5 and FIG. 1) the stress index is low in the presence of L-carnitine and much higher in the presence of D-carnitine.
The antagonistic effect of the two optical isomers of carnitine is also made evident by the fact that L-carnitine reduces the coronary-dilator effect induced by adrenaline, whereas D-carnitine increases it.
The action of L-carnitine and D-carnitine against adriamycin-induced cardiotoxicity was investigated using isolated rat heart perfused as per the Langendorff method, with Tyrode's solution at the rate of 0.1 ml/min.
The perfusion medium containing adriamycin at the concentration of 0.2 mg/ml was perfused on the heart until heart rate was reduced by 30% compared to the basal value. This reduced heart rate was accompanied by reduced contractile force and coronary flow rate.
Successively, Tyrode's solution containing L-carnitine or D-carnitine at a concentration of 5.08 mM or Tyrode's blank solution (control group) was perfused on the heart for 90-120 min.
The graphs appearing in FIGS. 2, 3 and 4 show that the repairing effect against cardiac damage caused by adriamycin administration is exclusively exerted by L-carnitine, whereas D-carnitine exhibits an opposite effect antagonizing that of L-carnitine. D-carnitine appears incapable of even partially restoring cardiac function.
The technique described by W. Shaper, M. Hofmann, K. D. Muller, K. Genth and M. Carl in Basic Res. Cardiol., 74, 224-229 (1979) was employed, with simultaneous occlusion of two coronary arteries in the same heart, for producing ischaemic areas with equal dimensions in identical haemodynamic conditions.
Successively, one of the ischaemic areas was perfused with a D-carnitine solution and the other with L-carnitine. Both solutions had the same concentration of carnitine (approx. 0.5 millimoles).
It was determined that, while the extension of the ischaemic area perfused with the D-carnitine solution remained unchanged, the extension of the ischaemic area perfused with the L-carnitine solution was reduced by approximately 60% as compared to the pre-infusion value.
TABLE 1__________________________________________________________________________Isolated rabbit heart. Four adrenaline injections (0.5 mcg) with 5-minuteintervalsbetween injections. Changes in coronary flow ml/min.(mean � S.E.)no. of adrenaline 0.5 mcg % valuesGroups hearts basal values 1st injection 2nd injection 3rd injection 4th injection__________________________________________________________________________Controls 9 23.6 � 1.50 -0.76 � 6.65 -5.86 � 5.45 +7.85 � 8.24 +12.74 � 5.06 (a)L-carnitine 9 27.0 � 0.91 -14.6 � 6.43 +5.97 � 5.38 +3.73 � 6.08 +0.21 � 4.051 � 10-5 g/lD-carnitine 11 23.4 � 1.02 -3.09 � 3.01 +6.63 � 6.16 +10.6 � 3.48 +9.83 � 2.621 � 10-5 g/l (b) (c)__________________________________________________________________________ Statistically significant values versus controls (a) 0.05>p>0.02, (b) 0.02>p>0.01, (c) 0.01>p>0.001
TABLE 2______________________________________As in Table 1.Tension force increase peak (grammes) (mean � S.E.) adrenaline 0.5 mcg no. of 2nd 3rd 4thGroups hearts 1st injection injection injection injection______________________________________Controls 9 2.82 � 0.41 2.92 � 3.17 � 3.43 � 0.32 0.35 0.59L-carnitine 9 1.73 � 0.23 2.23 � 2.68 � 3.02 �1 � 10- 5 g/l (a) 0.08 0.23 0.33D-carnitine 11 2.48 � 0.30 3.12 � 3.13 � 3.22 �1 � 10-5 g/l 0.27 0.30 0.29______________________________________ Statistically significant differences versus controls (a) 0.05>p>0.02.
TABLE 3______________________________________As in Table 1. Tension forceduration (seconds) induced by adrenaline (mean � S.E.) adrenaline 0.5 mcg no. of 2nd 3rd 4thGroups hearts 1st injection injection injection injection______________________________________Controls 9 49.2 � 5.15 61.4 � 61.0 � 71.0 � 9.81 6.63 10.1L-carnitine 9 37.8 � 3.66 50.4 � 55.7 � 58.6 �1 � 10-5 g/l 4.48 5.93 5.31D-carnitine 11 73.5 � 8.70 80.0 � 83.5 � 86.2 �1 � 10-5 g/l (a) 11.2 9.05 11.4______________________________________ Statistically significant differences versus controls (a) 0.05>p>0.02.
TABLE 4__________________________________________________________________________As in Table 1. Increase in heart rate, beats/minute (mean � S.E.)no. of adrenaline 0.5 mcgGroups hearts basal values 1st injection 2nd injection 3rd injection 4th injection__________________________________________________________________________Controls 9 184 � 6.5 +22 � 13.5 +29 � 3.5 +29 � 6.8 +26 � 11.8L-carnitine 9 178 � 4.6 +33 � 6.7 +32 � 10.0 +44 � 10.0 +33 � 13.41 � 10-5 g/lD-carnitine 11 177 � 4.4 +53 � 4.1 +46 � 6.1 +53 � 9.8 +46 � 4.71 � 10-5 g/l (*)__________________________________________________________________________ (*)Statistically significant differences versus controls 0.05>p>0.02.
TABLE 5______________________________________As in table 1. Effect of stress [∫Δg.t] � Δr/100 (mean � S.E.) adrenaline 0,5 mcg no. of 2nd 3rd 4thGroups hearts 1st injection injection injection injection______________________________________Controls 9 105.8 � 182 � 203.5 � 294.6 � 16.5 40.8 41.5 89.1L-carnitine 9 48.0 � 9.4 94.4 � 153.0 � 183.3 �1 � 10-5 g/l (c) 14.6 31.2 43.5D-carnitine 11 255.4 � 432.4 � 425.2 � 492.0 �1 � 10-5 g/l 44.2 (b) 95.6 85.4 123.3______________________________________
Two composition examples for the manufacture of tablets are given hereunder
______________________________________Example 1______________________________________L-carnitine 330.0 mgMagnesium stearate 50.0 mgMicrocrystalline cellulose 240.0 mg 620.0 mg______________________________________
______________________________________Example 2______________________________________L-carnitine 330.0 mgStearic acid 35.0 mgMicrocrystalline cellulose 230.0 mg 595.0 mg______________________________________
|Cited Patent
|Filing date
|Publication date
|Apr 28, 1976
|Feb 21, 1978
|Felice Stephen L De
|Method of improving the myocardial function by the administration of carnitine
|Sep 16, 1980
|Feb 16, 1982
|Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
|Pharmaceutical composition comprising L-carnitine for the treatment of hyperlipidaemias and hyperlipoproteinaemias
|Citing Patent
|Filing date
|Publication date
|Apr 29, 1988
|Nov 28, 1989
|Shug Austin L
|Method for preventing diet induced carnitine deficiency in domesticated dogs and cats
|Jun 22, 1992
|Mar 9, 1993
|Lonza Inc.
|Carnitine-supplemented diet for starter pigs
|Jun 22, 1999
|Mar 20, 2001
|The Iams Company
|Process for promoting weight loss in overweight dogs
|Mar 27, 1998
|Jun 12, 2001
|Sigma-Tau Healthscience S.P.A.
|Nutritional supplement for facilitating skeletal muscle adaptation to strenuous exercise and counteracting defatigation in asthenic individuals
|Mar 27, 2001
|Oct 7, 2003
|The Procter & Gamble Company
|Limiting weight gain of cats by feeding carbohydrate source that excludes rice
|Jul 5, 2000
|Feb 21, 2006
|The Iams Company
|Nutritional composition for weight management
|Mar 27, 2001
|Aug 30, 2001
|Sunvold Gregory D.
|Use of carbohydrate source to limit weight gain in cats
|Apr 28, 1989
|Nov 2, 1989
|Shug Austin L
|Method for preventing diet-induced carnitine deficiency in domesticated dogs and cats
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Sep 18, 1990
|Fee payment
Year of fee payment: 4
|Sep 19, 1994
|Fee payment
Year of fee payment: 8
|Oct 1, 1998
|Fee payment
Year of fee payment: 12


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Pierre Thomas signs with New Orleans Saints but still wants more
[URL="http://api.tweetmeme.com/share?url=http://sports.espn.go.com/nfl/news/story?id=5286786&campaign=rss&source=NFLHeadlines&service=tinyurl.com&source=espn"][IMG]http://api.tweetmeme.com/imagebutton.gif?url=http://sports.espn.go.com/nfl/news/story?id=5286786&campaign=rss&source=NFLHeadlines[/IMG][/URL]New Orleans Saints general manager Mickey Loomis says running back Pierre Thomas has signed his restricted free agent tender, but Thomas' agent says he still wants a better deal.
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Endicott News
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Click here to print the obituary below
Clifford C. Bowen(Feb. 8, 1913 - March 31, 2014)
LONDON - Clifford C. Bowen, 101, of Dublin, Ohio, formerly of London, died Monday, March 31, 2014.
Born in Hazard Kentucky on Feb. 8, 1913, he was the son of John and Nellie (Grant) Bowen.
Veteran of
World War II
. Clifford worked as a coal miner in Kentucky and later moved to Detroit to work with Ford,
General Motors
and Bowers Roller Bearing. He was a member and Quartermaster of the former H.V. Christopher
Post No. 1176.
Survivors are his granddaughter, Mandy (Steven) Walsh of Dublin; and great-granddaughter, Jessica Walsh of Dublin.
He was preceded in death by his parents; and wife, Lucille Bowen in 1973.
Friends may call at the EBERLE-FISHER FUNERAL HOME AND CREMATORY, 103 N. Main St., London, from 2-3 p.m. on Friday, April 4, 2014 with services beginning at 3 p.m. Pastor Gaye Gossard will be officiating. Interment will be in Kirkwood Cemetery, London.
Memorials may be made to the West Jefferson VFW Post.
Online condolences may be made to the family at
Funeral Home
Eberle-Fisher Funeral Home
103 North Main Street
London, OH 43140
Published in The Madison Press on Apr. 3, 2014


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Carlos 1 To 1 (Men At Play)
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There are 4 comments on this gallery
okto85January 03, 2008 - 20:56:24 | See all My Comments
damn guys! these r gift from god but not for us
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Is it me or is it getting HOT in here?
CrypticHillMay 01, 2007 - 19:56:51 | See all My Comments
You can't have him... I want him.
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he is soooo fukn hot....i want him sooo bad!!
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Poll results: Which iPod nano will you buy?
The most recent Lounge Poll, "Which iPod nano will you buy?", is now closed.
With over 7,300 votes cast, a majority of responding readers indicated that they preferred black nanos to white ones, with almost twice as many picking black 2GB models (7%) over white 2GB models (4%), and black 4GB models (44%) over white 4GB models (24%). Most interestingly, six times as many people indicated interest in the more expensive 4GB model as for the less expensive 2GB model, with only 11% of respondants opting for 2GB, and 68% opting for 4GB. We were also surprised to see just what fraction of readers said they would buy a nano: 79% said they'd buy one of the four models, while only 21% said they would not.
Complete results are available in Read More below, and at the Lounge Poll archives. Our new poll, "Which feature do you most want Apple to add to iPods?", is now open. You can find it on the left column below Ask iLounge.
Related Stories
- iLounge Weekly coming Monday, sign up now
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- Follow our live coverage of today's Apple event
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- Cool tips for that new iPhone, iPad, Apple Watch, or Apple TV you found under the tree
Yay! The one I have is ... the most popular… um…
Posted by Rex StJames in East Amherst, NY, USA on September 28, 2005 at 2:26 AM (CDT)
What is so surprising about these results? People want the black one, instead of the white one… of course they do, Apple hasn't offered a black ipod before. People want a 4 GB? Yeah of course they do, the minis they had or could have had were bigger than the 2 GB. Why would you downgrade in size if you could stay the same but drop the form factor exponentially? And what is surprising about 4/5 iLoungers buying these? People here buy the newest iPods as soon as they come out, we're diehards.
Posted by spimp31 in East Amherst, NY, USA on September 28, 2005 at 1:30 PM (CDT)
Apple hasn't offered a black ipod before
is the U2 ipod not counted as black?
Posted by iJay in East Amherst, NY, USA on September 28, 2005 at 6:33 PM (CDT)
Nah, I wouldn't count it as black, because you have the U2 part to go along with it. Many people (myself included) who are not the biggest U2 fans didn't want the iPod even though we liked the black. I think the all black nano is more attractive than the U2 black and red model.
Posted by spimp31 in East Amherst, NY, USA on September 28, 2005 at 8:19 PM (CDT)
personally, i like my 6GB mini much much better. just becuz it doesnt have a color display doesnt make it anymore cooler.
Posted by jen in East Amherst, NY, USA on September 28, 2005 at 10:22 PM (CDT)
Yes, because the only difference between the mini and the nano is the color screen…...
Jen, if storage space is all that matters to you why didn't you just buy a 20gb ipod for only 50 bucks more then the mini? The same reason you didn't buy the regular ipod is the same reason people buy a nano over the mini. If I wanted to carry a brick, I would get into contracting. Jealousy is a bitter emotion….
Posted by dan5 in East Amherst, NY, USA on September 29, 2005 at 12:34 AM (CDT)
"Jealousy is a bitter emotion…."
Yes it is, and we can tell you're completely jealous and intimidated by Jen's monstrous schlong ;-)
Sorry, the mini for many users is a much better iPod than the nano. It's sure not jealousy that fuels this feeling - I wouldn't trade my 1G mini for a brand new nano even though it's technically an upgrade. I've ranted enough about what I don't like about the nano in the forums so I'll spare you a repeat, but your attempts at calling people who don't like the nano "jealous" is childish to say the least. Gods forbid someone doesn't like your new materialistic attempt at buying yourself a personality.
Posted by Code Monkey in East Amherst, NY, USA on September 29, 2005 at 8:32 AM (CDT)
What is the next and newest ipod (regular ipod - between 20 and 60GB) to be released and what is it going to be like. What kind of upgrades and when might it be released? I want to buy a 60GB but im afraid at the rate they release new versions, im going to buy one and then something new will come out immediately after. Any suggestions?
Posted by ac7 in East Amherst, NY, USA on September 29, 2005 at 8:38 PM (CDT)
"im going to buy one and then something new will come out immediately after. Any suggestions?"
Sure. Wait until the next model comes out, then buy the old model from one of the clearance sales at Amazon or elsewhere. You get a substantial discount for buying "last year's model", plus you don't have to worry about it being immediately obsolete because it already has been.
Posted by Michael Portuesi in East Amherst, NY, USA on September 30, 2005 at 5:17 PM (CDT)
Recent News
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text:
...and other jazz happenings around San Diego June 28-July 3
Robert Bush noon, June 26
Golden moments and minor disasters at the altar.
Chunks of ice rode the whitecaps as the Nantucket ferry steamed out of the harbor in Woods Hole and into the Atlantic. The March wind had driven Isabel into the warmth of the cabin, while ...
Robert Bush noon, June 26
Judith Moore 11:40 a.m., June 26
Daniel Powell 10:45 a.m., June 26
Julie Stalmer 7:15 p.m., June 25
Ken Harrison 3:35 p.m., June 25
Walter Mencken 2:02 p.m., June 25
Josh Board 12:58 p.m., June 25
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Don't Miss
- Have Preds assembled pieces for long term success?
- Weber thwarted again; loses Norris bid to Duncan Keith
- Preds give Rinne insurance for two years, re-sign Hutton
- Could the Preds trade Shea Weber next summer?
- Weber's teammates endorse him for Norris
- Shea Weber nominated for Norris Trophy
- Barry Trotz has coached his final game for Preds
- Preds hang seven more on Minnesota to close out 13-14 season
- Preds hang seven on Blackhawks
- Shea Weber: "Something's got to change"
All posts tagged "Music City Center"
Cigarran: All-Star Game could come to Nashville "within the next three years"
Predators Chairman Tom Cigarran mentioned to the Skate of the Union crowd that Nashville could host an...
Colin Wilson to appear at this weekend's Music City Sports Festival
The Predators forward will be just one of a handful of athletes holding an autograph session at...
The 303:30 – Ads HC Dean Evason, draft guru Corey Pronman and Willy Daunic on the Music City Sports Festival
This week, we talk NHL Draft with Corey Pronman, recap Milwaukee's season with Dean Evason and get...


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01/25/2013 07:23 PMPosted by DayuvIt's our expectation that Heroic raiders should have no interest in 5.2 Raid Finder gear. If you have item level 509+ gear from 5.0/5.1 Heroics, then the question is, why would you want item level 502 gear from the Raid Finder?
Heroic Raider =! raider with full best in slot gear.
Admittedly, I'd say the chances someone whose downed heroic sha by 5.2 having a 509 ilvl is quite high due to upgrading. On the other side, the chance they have full 509 gear is quite low so there likely will be some upgrades in LFR. Especially trinkets.
Now tier, if they gate it (as expected in 1/4 at a time starting 1 week after normal), there's a pretty good chance a good number (but not all ofc because of RNG and not that many drop) heroic raiders won't need to farm tier since tier gear is normally at end of the instance so they should have a good 3-4 weeks before tier is available in LFR where it can be farmed in normal/heroic.


text:
An American Shipper poll of shippers and forwarders revealed that nearly 90 percent believe at least some cargo will be delayed by the verified gross mass rule that went into effect globally today.
The U.S. Commerce and Energy departments have started an industry advisory group, along with their counterparts in Mexico, to make recommendations to strengthen cross-border trade and investment in the energy sector.
PARIS Optimal Transport Planning, a technology division of Hutchinson Ports (UK), created Boxreload, a platform allowing trucking companies and third parties in the U.K. to post loads online, which can only be viewed by "pre-selected and trusted partners."
Registration takes less than 1 minute.
Despite the European Union and United States agreeing to ease economic sanctions placed on Iran in 2009, multinational companies must still ensure rigorous compliance with "secondary" U.S.-Iranian sanctions.
SSA Marine's Oakland International Container Terminal will make appointments mandatory for the majority of containerized import pick-ups in order to shorten lines at terminal gates and speed up cargo delivery to customers.
South Korean ocean carrier Hanjin asked Seaspan and others for a reduction in existing charter rates for a period of three and a half years in exchange for securities in a restructured Hanjin.


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"Local budding professional."
"Just move here from Chicago"
"My name is Peju Alawusa and I am a graphic designer and the owner of Bodega Design Lab, a graphic design studio.—I specialize in Print and web design. Currently..."
"Web developer and entrepreneur."
"Hello, I'm Aaron White, President & Creative Director of "Aaron White & Assoc Creative Design," a full-service Advertising, Graphic Design..."
"I'm looking to get into the field of graphic design and have so far been teaching myself. Hoping to connect with others, gain knowledge and skills, and have..."
"Just moved here from NY, was painting and drawing then discovered Illustrator and graphic arts and fell in love with that art form"
"I am a technology teacher. I use the AI and PS in my technology classes. I do web design work on the side. I'm looking to better my knowledge and skills..."
"Hello! I love adobe and would be happy to learn more and gain experience. "
"Hi! I'm David and I love creating compelling illustrations to paint a story!"
"Hello! I am relatively new to Adobe Creative Suite and have been teaching myself InDesign. I would love to meet more experienced designers and expand my skill set."
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Best Street Art Ever
May 23rd, 2012
A collection of some of the most inventive, creative and downright awesome street art that we have ever seen. Social commentary, optical illusions and even guerrilla knitting. It's all here and it's all AWESOME!
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Voomed Macho Video One Humor LiveDump Friday Funnies Celeb Buzzer Viral Videos xDumper College Funnie Girl Videos Real Funny Videos Viral Station Top 50 Funny Sites Cure My Boredom Celebrity Buzzer Interesting Articles Funny Sh#t 911.com Celeb Tweets Abum Reddit Pugorama Heavenly Babes Muppetism


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SparkFun will be closed Monday 7/4 for the holiday. All orders placed after 2pm MT on Friday 7/1 will be shipped out next week.
Track My Order
Frequently Asked Questions
International Shipping Info
Send Email
Mon-Fri, 9am to 12pm and
1pm to 5pm U.S. Mountain Time:
(303) 284-0979
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Member Since:
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Product WIG-08627
about 6 years ago
My LogomaticV2 is not logging data at 115.2kbaud correctly?
Sending it:
0x 00 01 02 03 04 …
Gets recorded as
0x FD FB F9 F7 F5 …
The pattern is consistent. Any ideas what is going on here?
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XPRIZE is an innovation engine. See who we are
Deep space has long captivated our imaginations, but the deep ocean, right here on Earth, remains one of the most underexplored places known to humans.
This week, cartographers and experts meet in Monte Carlo, to discuss their plans to map the ocean floor by 2030. BBC's Roland Pease reports on the ocean-mapping options.
Now in its fifth year, the $10 million Qualcomm Tricorder XPRIZE competition — which aims to create a portable medical device akin to the fictional tricorder of Star Trek fame — is moving toward naming a winner in early 2017.
See more
How will #AI change your world? @IBMWatson & @XPRIZE put up $5M to find out. Now open: https://t.co/sQjHpl7oRp https://t.co/NuuaMukTxZ
This personal delivery drone is set for a test run.
This personal delivery drone is set for a test run. View on Google+
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Posted by Willy Franzen on March 23, 2013. Jobs updated daily.
|Littoral Combat Ship Entry Level Network Engineer
Pittsfield, MA
|Littoral Combat Ship Infrastructure Network Engineer
Pittsfield, MA
|Project Engineer /Littoral Combat Ship Cable Team / Marinette, WS
Marinette, WI
|Automotive Sales Director, BL Industry&Society
Detroit, MI
|Rural Society Argentine Steakhouse Barback
Chicago, IL
|Project Manager - Communications and Society Program
Washington, DC
|Director of Hoover Legacy Society, Hoover Institution
Stanford, CA
|Consultant, Society for Biological Engineering - AIChE
New York, NY
|Head of Tocqueville Society and Leadership Giving
Jacksonville, FL
|Marketing Manager, Community & Society Marketing
Hoboken, NJ
I grew up in a coastal New England town and spent my summers on the beaches of the Atlantic. Now I live in the Midwest, and even though we have beaches and coastal areas, it's just not the same. I miss the smell of salt in the air, the seafood, and the opportunity to go fishing with the hope of catching a true sea monster. If I ever get back out there, I hope that there will be more to enjoy than just the salty air. Our coastal areas are some of our most ecologically important and sensitive places, and that's why the American Littoral Society is working to protect them. Founded in 1961, they're a Highlands, NJ based non-profit organization that "promotes the study and conservation of marine life and habitat, protects the coast from harm, and empowers others to do the same."
I'll admit that I had to look the word "littoral" up before I wrote this post. According to Wikipedia, it means "the part of a sea, lake or river that is close to the shore." There's a lot of littoral zone in the U.S., and that means that the American Littoral Society is always busy. They have some location specific programs focused on places like Barnegat Bay, Jamaica Bay, and Delaware Bay, and their are also broader programs like fish tagging, litigation, and beach grass planting. If it has to do with protecting coastal areas, there's a good chance that the American Littoral Society is working on it. If you love the coast as much as I do, you may want to check out the American Littoral Society's jobs on Idealist. Right now they're looking for a Conservation Coordinator, and the position looks perfect for a new or recent grad.
Links to Help You Begin Your Research
What do you know about the American Littoral Society?
We've identified American Littoral Society as having career opportunities in the following categories:
|Customer Service Specialist - Bluefield
Dish Network Springfield, VA
|Contact Center: Become a Customer Service Rep - Bluefield
Dish Network Springfield, VA
|Customer Service Representative - Bluefield
Dish Network Springfield, VA
|Call Center: Become a Customer Service Rep - Bluefield
Dish Network Springfield, VA
|Waiter: Become a Customer Service Rep - Bluefield
Dish Network Springfield, VA


text:
Le Carré d'Aix, Savoie (department)
- Free WiFi
Main amenities
- 19 guestrooms
- Breakfast available
- Self-serve laundry
- Limited hour front desk
- Tour/ticket assistance
For families
- Cribs/infant beds (surcharge)
- Refrigerator
- Television
- Laundry facilities
- DVD player
- Elevator/lift
What's around
- In Aix-les-Bains City Center
- Grand Cercle Casino (0.1 mi / 0.2 km)
- Faure Museum (0.3 mi / 0.5 km)
- Thermes Chevalley (0.4 mi / 0.6 km)
- Congress Centre (0.4 mi / 0.7 km)
- Chateau de la Roche du Roi (0.9 mi / 1.4 km)
Le Carré d'Aix, Savoie (department)
Hotel Info: 866-539-8117from $39
- Economy Single Room
- Economy Double Room
- Standard Single Room
- Comfort Single Room
- Comfort Double Room
- Standard Room
- Economy Room
- Single Room (Loft)
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 19 rooms
- This hotel is arranged over 5 floors
- Check-in time 2 PM-8 PM
- Check-out time is 11 AM
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets allowed (dogs only) *
- 1 per room
- Free WiFi in rooms
Nearby Two Star Savoie (department) hotels
In the hotel
- Breakfast (surcharge)
- Front desk (limited hours)
- Tours/ticket assistance
- Laundry facilities
- Number of buildings/towers - 1
- Year Built 1850
- Elevator/lift
In the room
- Ceiling fan
- Soundproofed rooms
- Balcony
- Hair dryer (on request)
- DVD player
- Desk
- Free WiFi
- Phone
- Refrigerator
Top Savoie (department) hotels
Recently reviewed hotels in Savoie (department)
- ibis Styles Annecy Gare CentreFrom
"Great place. Will consider it again."Jun 11, 2016
- Best Western Hotel InternationalFrom
"We managed to get a room here on a busy Saturday evening and found it very convenient to visit the lake and old part of Annecy (about a 15 minute walk). The car parking in the…"May 23, 2016
- Hôtel Le Saint VincentFrom
"When we arrived,Samuel, the proprietor greeted us and checked us in. Our room was so cute, with a view of a vineyard. We wanted to stay another night, but sadly, they were fully…"May 23, 2016
- Chateau des Comtes de ChallesFrom
"Good comfort, great location off a beaten path, picturesque setting; rooms are quite spacious, superb restaurant, this is my go to place"May 17, 2016
Le Carré d'Aix, Savoie (department)'s small print
Also known as
- Carré d'Aix
- Carré d'Aix Aix-les-Bains
- Carré d'Aix Hotel
- Carré d'Aix Hotel Aix-les-Bains
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
- Tourism fee: EUR 0.95 per person, per night
Optional extras
Breakfast is offered for an extra charge of EUR 8 per person (approximately)
Cribs/Infant beds are available for EUR 10 per night
Pets are allowed for an extra charge of EUR 5 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
The Honolulu-based liner carrier will launch its South Pacific Express service in August, which will transport U.S. West Coast cargo transshipped at Honolulu to Samoa, American Samoa, Tonga and Fiji.
The French ocean carrier said it intends to have Singapore's Neptune Orient Lines delisted from the Main Board of the Singapore Exchange as it pushes forward to acquire all of the shipping company's shares.
A new port navigation system consisting of 12 off-shore buoys and two land-based range markers, will allow for night time operations at the Liberian port for the first time in three decades, APM Terminals said in a statement.
Registration takes less than 1 minute.
The U.S. Department of Transportation is looking into how delays at ports and other loading and unloading facilities may be affecting driver compliance with hours-of-service rules designed to increase safety.
Ship owners on Wednesday broke off rate negotiations with struggling South Korean shipping conglomerate Hyundai Merchant Marine without reaching an agreement, according to multiple reports from Korean media outlets.
As part of its ongoing expansion in North America, Mainfreight has recently added two new warehouses at Newark, N.J. and Dallas.


text:
Home > All Cities > Millsboro, DE Real Estate Listings > Pines At Long Neck Subdivision
Properties for sale in the Pines At Long Neck Subdivision, Millsboro, DE
Properties 1 to 4 of 4
54 White Pine, Millsboro, DEList Price: $172,900 | Bed:3 | Bath:2.00
Wow! Remodeled baths and kitchen in 2016. This three bed room two bath home is in move in condition and has a fantastic yard with a huge screen gazebo, deck, shed and a rear drywall tiki room for summer entertainment with electric and cable. New Amenities: hardwood floors in living room, kitchen and rear Florida room. New carpets thru out, Washer and Dryer are 18 months old. Also new in 2016 gas stove, side by side refrigerator with ice maker, dishwasher and microwave. The kitchen has been remodeled with composite counters and the breakfast bar seats 2. All the ceiling fans, faucets, sinks, shut off valves have been replaced. Front porch is three months old with vinyl rails and trek flooring. Tile floors in both baths and more. Upgrades are too numerous to mention so stop by or call today. New roof on rear Florida roof. Class C Cable TV Prewired, Ceiling Fan(s), MBED-Full Bath, Storm Door(s), Walk-In Closets Gazebo, Storage Shed/Outbuilding Dishwasher, Dryer-Electric, Fridge with Ice Maker, Microwave, Oven/Range Gas, Washer, Water Heater Electric Gas - Propane Central A/C Cleared, Partially Wooded
Listing Office: GOLDEN COASTAL REALTY | MLS ID#: 708231
123 White Pine Dr, Millsboro, DEList Price: $159,000 | Bed:3 | Bath:2.00
Spacious and Bright Pondview home featuring open floor plan with three bed rooms, two bathrooms, huge living room, family room, eat in kitchen, three season room, and wheel chair rampinto side entrance. Home is located on a in a quiet community with no ground rent and a pond view. The home is close to boating, golf, shopping, restaurants and amp; the beaches too. Bedroom-Entry Level, Cable TV Prewired, Ceiling Fan(s), Fireplace-Wood, Insulated Window(s), MBED-Full Bath, Skylight(s), Walk-In Closets Storage Shed/Outbuilding Water Heater Electric Gas - Propane Central A/C
Listing Office: MAGGIO SHIELDS REAL ESTATE BROKERAGE | MLS ID#: 710339
212 Long Neck, Millsboro, DEList Price: $152,900 | Bed:3 | Bath:2.00
Only minutes to the water, boardwalk, outlets, golfing and outdoor activities. This Class C home is ready for a new owner who loves easy living at the beach. This three bed room two bath home has tilt removal windows, rear Florida room, irrigation system, double seater shower, open kitchen to dining room, cathedral ceiling in living room, breakfast bar, lots of closets, huge driveway and a rear shed. If you are looking to be close to the beach and at an affordable price then this home is for you. Only 18 minutes to the Rehoboth Boardwalk or Lewes beaches. If you like to fish its only a shorter drive to Masseys Landing to put your boat in or fish on the pier. Call today for more details. Ceiling Fan(s), Insulated Door(s), Insulated Window(s), MBED-Full Bath Storage Shed/Outbuilding Dishwasher, Fridge with Ice Maker, Microwave, Oven/Range Gas, Washer, Water Heater Electric Forced Air, Gas - Propane Central A/C 56x133x71x126 Cleared
Listing Office: GOLDEN COASTAL REALTY | MLS ID#: 702882
42 White Pine Dr, Millsboro, DEList Price: $113,000 | Bed:3 | Bath:2.00
This one is a Short Sale! The bank just updated the approved price at 113,000 At this time we will only consider full price offer with buyer to pay 3% negotiator fee. ( the list price can be reduced by the 3% for cash buyers or as seller assist for conventional loans. Home backs to pond! Nice home in nice community close to boating, beaches and major shopping. Great Location! Rear deck and shed, fantastic room has pond views. No lot rent-Fee simple Ceiling Fan(s), Fireplace-Gas, Insulated Door(s), Insulated Window(s), Tub-Soaking/Whirlpool Dryer-Electric, Fridge with Ice Maker, Microwave, Oven/Range Gas, Range Hood, Washer, Water Heater Gas Forced Air, Gas - Propane Central A/C 60x125
Listing Office: DELMARVA RESORTS REALTY | MLS ID#: 605399


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text: I'm trying to have an empty TextMorph with a default font size of 12 points, where the original default is 9pts. If I bring up the halo and change the font size to 12pts, the empty TextMorph will still default to 9pts when text is entered into it. I can sort of get around this by putting a space in the TextMorph, then changing the font via the halo to be 12pts. However, this seems rather clunky, and as such was wondering if there might be another way to accomplish this?