text:
Wealthy 'not paying enough'
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Rich people with expensive properties are not paying their fair share for Earthquake Commission land cover, says EQC chairman Michael Wintringham.
There needs to be more "social equity" around the way that land is covered because the existing system favours those with more expensive homes, he adds.
Wintringham, speaking to a grouping of Christchurch business people yesterday said he had pushed for a long time for a review of EQC's cover for land.
Both EQC's cover for residences and contents had been capped at a dollar value. Since the early 1990s EQC has been responsible for the first $100,000 of property damage and the first $20,000 of contents in natural disasters.
However, EQC's cover for land was done on a square metre basis and by value.
This gave a natural advantage to those paying the yearly EQC fee who lived in more expensive homes, because they paid relatively less for the cover, Wintringham said.
"There is not a premium charged for our land cover. The premium is a percentage of the residential property cover, which in effect means that those who are fortunate to have a highly expensive section with a sea view get a greater degree of cover than those who live in more modest properties.
"So there's a social equity issue there, about who is bearing the risk and who is bearing the benefit. There's a fundamental question in there . . . I'm pretty keen that's resolved."
His comments came yesterday while talking about the EQC's role in Canterbury, and a Government-led review of the Earthquake Commission Act 1993 looking at EQC cover and how much it costs.
The Government's "first impressions" of the review are expected to be made public in 2013.
EQC chief executive Ian Simpson said there had been a lot of concern about the larger claims being double-handled by EQC and the insurers, and work had to be done in reviewing the act to avoid that happening again.
"That's [created] a lot of distress and a lot of noise in terms of how that's working and not working. So what practically can we do next time to make sure that's much clearer, much easier, much more practical."
EQC wanted to be able work better with customers, and remove some of the "friction" between different players involved in the quakes.
Wintringham said with the existing system EQC provided the first $100,000 of cover, potentially for multiple events.
But there could be a more collaborative approach, he suggested. "What say we went dollar for dollar with the private insurers, dollar for dollar up to $300,000, we pick up $150,000 they pick up $150,000. There's a complete alignment of incentives."
There could be "a whole lot of other wrinkles" attached to any such a change to the system, he acknowledged.
"[But] we are keen to ensure that the lessons learned from Canterbury which have caused either unnecessary churn or unnecessary delay or unnecessary distress, are picked up and incorporated and arrangements are put in place."
- The Press
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subset: commoncrawl


text:
This page contains DeadLight Unlockables for PC called "Steam Achievements" and has been posted or updated on Oct 29, 2012 by koku.
- Developer: Tequila Works
- Publisher: Microsoft Game Studios
- Genre: Action Platformer
- Release: Oct 25, 2012
- ESRB: Mature
Steam Achievements
To unlock the following, you have to play the game and collect/Earn achievements. You can find those earned achievements in your Game-Main menu or you can view them if you signup at one of the Steam communities.
|How to Unlock:
|Another one bites the dust
|Perform a combo on an enemy
|Come Sail Away
|Make it to the end
|Don't Lose Your Head
|Eliminate an enemy with a single melee attack
|Flirtin with Disaster
|Tackle an enemy
|Forget Me Nots
|Locate every of Randall's memories
|Go back to hell
|Execute an enemy
|Goodbye stranger
|Push a zombie over a railing
|Holding out for a Hero
|Reunite with Stella
|I Ran (So Far Away)
|Escape from the warehouse
|I want it all
|Get 100% of Deadlight
|In the Army Now
|Get to the military control
|Invisible Touch
|Beat the high score in Madness Mansion
|Is there anybody there?
|Finish Randall's dream
|Roll to avoid lethal fall damage
|Knockin' on Heaven's Door
|Tackle a door
|Land Down Under
|Follow the Ratman to his den
|Lay your hands on me
|Survive a close encounter
|Lazing on a Sunday afternoon
|Face someone from Randall's past in the Park
|Let there be rock!
|Beat the high score in Raven Thunder's Rock Legend
|Never Gonna Give You Up
|Locate Parker in the hockey arena
|No Pain, No Gain
|Beat the high score in Sport Daisy
|Pickin' Up Strangers
|Locate every the IDs
|Rust in peace
|Perform a headshot
|Spreading the disease
|Get infected by a friend on the leaderboards
|Tainted love
|Finish Randall's flashback
|Tales Of Glory
|Finish the Nightmare mode
|Under pressure
|Finish Randall's nightmare
|Wanted Dead or Alive
|Reload the revolver really fast
|Welcome to the Jungle
|Get to the junkyard
|What You Need
|Locate the first health expander
|What's on your mind
|Locate a page of Randall's journal
Please Submit a Problem for any incomplete, non-working or fake cheat listed above.
If you know other secrets, hints, glitches or level guides, then please Submit your Cheats and share your insights with other gamers.
Stuck in this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
Lost Grimoires: Shard Of Mystery - Gameplay Video
- Jun 24, 2016, Views: 1
Asemblance - Gameplay Video
- Jun 23, 2016, Views: 1
Breached - Gameplay Video
- Jun 23, 2016, Views: 1
1917: The Alien Invasion - Gameplay Video
- Jun 23, 2016, Views: 2
- The Journey: Bob's Story, (PC)
- Deus Ex: Mankind Divided, (PS4)
- Skylanders Battlecast Cards To Life, (AND)
- LEGO Star Wars: The Force Awakens, (PS4)
- Mafia 3, (PS4)
- Forestry 2017 - The Simulation, (XONE)
- MX Vs. ATV Supercross Encore, (XONE)
- Tayutama 2: You're The Only One, (PC)
- Call Of Duty: Infinite Warfare, (PS4)
- Hyperburner, (iOS)
- Hero Siege: Pocket Edition, (iOS)
- Get 'Em, (iOS)
- Quest To Aztlan, (iOS)
- Paranormal Minis, (iOS)
- Station Manager, (iOS)
- Iron Mission - Classic Arcade Shoot'em Up, (iOS)
- Epic Flail (Noxus Ltd), (iOS)
- 2-bit Cowboy Rides Again, (iOS)
- Dungeons Of Chaos Unity Edition, (iOS)
- Rule With An Iron Fish, (iOS)
- Heroes Of Loot 2, (iOS)


text:
Gay Christian groups "disappointed" at registrar victory
Post your comment
Comments on this article are now closed.
Reader comments
People can hold any superstitious beliefs they want, heck, they can even believe in the sugar plum fairy if they want. But, I just cannot understand why such people expect to be 'respected'. I mean, why. In a modern world, are such people taken seriously? For educated people to believe in mystical men in the sky who are invisible, but know everything people do and say, is beyond stupiditiy.
Nobody forced this religious bigot to work as a registrar, that is what she chose, to conduct secular non -religious weddings and partnerships. Her whinging about her beliefs is like a vegetarian taking a job in an abbattoir, then complaining that they cannot do the job because of their beliefs.
There is a hell of a lot of difference between believing in imaginary invisible people in the sky, and actually being born gay.
Religious people are just nutters, not to be taken seriously.
If she doesn't want to do her job, she should quit or be fired
You're not helping you know. Insenstive, bigoted and dogmatic anti-Christian rants really do nothing to encourage an environment of tolerance, diversity and understanding for all of us. It might be an idea to practice what you preach and set an example rather than simply being just as narrow minded and prejudiced as those you would wish to condemn.
These comments are un-moderated and do not necessarily represent the views of PinkNews. If you believe that a comment is inappropriate or libellous, please contact us.
Most commented this week
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- Director claims Stonewall gay rights riots were a 'white event' 54


text:
Writing your will? Don't forget your online identity
From passwords and logins to profiles and accounts, Rosemary Caruso talks us through managing our online identities after we're gone.
- Print page
- Email this
- Permalink
When you're writing your will, it typically involves mentally dividing all the tangible assets you own - like furniture, cars, money and maybe some antique pieces.
But times are changing and there's something else that lawyers are telling us to consider and include in our wills and estates.
Rosemary Caruso from Tindall, Gask and Bentley firm explained further to Mornings.
"It's considering our digital assets or digital presence online, things like photos..."
"For younger people and those of us a bit older and have started using this technology, it's something we need to consider when thinking about what assets we're leaving behind."
Ms Caruso said we also need to ensure the executor of our will is familiar with technology and able to access the online aspects of our wills.
"Do they know the username, do they know the password? As much as we shouldn't write those things down, perhaps they need to be written and stored with our wills.
Aside from our social media profiles, emails and the like, Ms Caruso said we must also consider online banking, e-trading accounts and other financially related aspects that can also link back through our web presence.
"Those things need to be known by the executor and quite often the only knowledge of that is online, through emails and so forth."
"The problem at the moment is what's the solution?"
"We don't want to be writing our passwords down - do we store it with our wills, sealed in an envelope that only gets opened after our death? Maybe that's one solution.
"It's just thinking about these things because even as lawyers, it's not something that we really had thought about but it is becoming something we need to because as younger or older people embracing the technology, we need to be thinking about these things."
Hear Rosemary Caruso discuss what happens to our social media accounts in the event of our death, how executors can coordinate our online presence on our behalf and digital wills.
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Have you ever purchased from PartSelect.com before?
Thank you for helping make our site better.
Below is a list of all parts for the KitchenAid Refrigerator KSCS25FKSS02. To find the repair part you need, you can browse the list below or you can narrow your choices by searching for a part by name or description.
Sold individually.
This compression nut is used with the plastic water line of the icemaker assembly.
This arm is used to eject the ice from the icemaker into the bin.
This part is also known as the cycling thermostat and this bi-metal device controls the activation of the icemaker ejection cycle.
This part supplies water to the icemaker, water dispenser any anywhere else that requires water.
This door trim is located on the inside of the fridge/freezer door. It is held in with two end caps, and is used to store items in the door.
This kit no longer includes the connectors. It is only the tubing/water reservoir.
Note: This tubing requires an adapter coupler (PS369735) to take the tubing from 1/4 inch to 5/16...
All brand logos are trademarks of their respective owners.
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text:
This work was performed at the College of Veterinary Medicine, University of Georgia, Athens, GA, the University of Wisconsin, Madison, WI, and Veterinary Medical Specialists, Concord, CA.
Original Article
Phase I Clinical Trial of Vinorelbine in Tumor-Bearing Cats
Version of Record online: 10 MAY 2013
DOI: 10.1111/jvim.12101
Copyright © 2013 by the American College of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine
Volume 27, Issue 4, pages 943–948, July/August 2013
Additional Information
How to Cite
Pierro, J.A., Mallett, C.L. and Saba, C.F. (2013), Phase I Clinical Trial of Vinorelbine in Tumor-Bearing Cats. Journal of Veterinary Internal Medicine, 27: 943–948. doi: 10.1111/jvim.12101
This study was presented in part, in abstract form, at the Veterinary Cancer Society 35th Annual Meeting, Las Vegas, NV, 2012
Publication History
- Issue online: 15 JUL 2013
- Version of Record online: 10 MAY 2013
- Manuscript Accepted: 2 APR 2013
- Manuscript Revised: 15 FEB 2013
- Manuscript Received: 21 NOV 2012
Funded by
- University of Georgia Clinical Research committee
- Abstract
- Article
- References
- Cited By
- Cancer;
- Chemotherapy;
- Feline;
- Navelbine
Vinorelbine (VRL) has been investigated in dogs, but its use in cats has not been studied.
To determine the maximal tolerated dose (MTD) and dose-limiting toxicity (DLT) of VRL in tumor-bearing cats.
Cats were included in this prospective phase I trial if they had confirmed malignancy, received ≥1 VRL treatment, and had adequate follow-up. Previous treatment was acceptable, but concurrent chemotherapy or radiotherapy was not permitted.
Using a modified phase I design, cats were enrolled in cohorts of 3 at a starting dosage of 9 mg/m2. Cats tolerating the first treatment well were eligible to receive additional VRL treatments at escalating dosages; escalations beyond the perceived MTD were permitted based on individual tolerance. Intended treatment interval was 7 days. Patient histories, physical examinations, and complete blood counts were performed weekly.
Nineteen cats were included. Sixty-one VRL treatments were administered. Median number of treatments was 2 (range, 1–9). Starting dosages were 9–12 mg/m2. Maximal dosage administered was 15.5 mg/m2. The MTD was 11.5 mg/m2. Acute DLTs were neutropenia, vomiting, and nephrotoxicity. Other notable toxicities were weight loss and anemia.
Conclusions and Clinical Importance
Vinorelbine is tolerated in cats at a weekly interval. Recommended starting dosage is 11.5 mg/m2. Neutropenia was transient, lasting <7 days; vomiting was self-limiting in most cases. Although VRL-associated nephrotoxicity has not been reported, potential attribution of this toxicity to VRL must not be discounted. Further investigation of the efficacy of VRL in feline malignancies is warranted.
adverse event
blood urea nitrogen
complete blood count
dose-limiting toxicity
Eastern Cooperative Oncology Group
- FeLV
feline leukemia virus
feline immunodeficiency virus
maximal tolerated dose
red blood cell
Response Evaluation Criteria in Solid Tumors
Veterinary Cooperative Oncology Group Common Terminology Criteria for Adverse Events
Vinorelbine (VRL) is a semisynthetic vinca alkaloid that differs from vinblastine in its modification of the catharanthine ring and its increased lipophilicity.[1, 2] It is an antimitotic drug that has exclusive affinity for mitotic tubulin and tubulin-associated protein. VRL induces its cytotoxic effects by inhibiting microtubule dynamics.[3] Specifically, it destabilizes microtubules and inhibits their polymerization, eventually leading to destruction of the mitotic spindle, mitotic arrest, and ultimately cell death.[1, 4]
In studies in humans, VRL has shown efficacy in a variety of malignancies, including advanced breast cancer, non-small cell lung cancer, Hodgkin's and non-Hodgkin's lymphoma, and ovarian cancer.[5-7] It often is incorporated into multiagent protocols. The dose-limiting toxicity (DLT) is neutropenia, and mild emesis has been noted. As compared with vincristine, VRL is substantially less neurotoxic, likely because of its actions on mitotic microtubules rather than axonal tubules.[8] Increased liver enzyme activities have been reported, but substantial hepatotoxicity appears to be rare.[9] To our knowledge, nephrotoxicity has not been reported.
A phase I clinical trial investigating VRL in dogs with various malignancies demonstrated a relatively mild toxicity profile, with neutropenia as the DLT.[10] Other notable toxicities included inappetence, vomiting, and diarrhea. Hepatic cirrhosis was noted in 1 dog, possibly attributable to VRL treatment. A starting dosage of 15 mg/m2 was recommended, and activity against bronchoalveolar carcinoma was observed.
Subsequently, the efficacy of VRL was evaluated for the treatment of cutaneous mast cell tumors in dogs. All dogs were treated at a dosage of 15 mg/m2, and neutropenia was the most common adverse event. Overall response rate was 13%.[11]
Elucidation of tolerability, toxicities, and a safe starting dosage of VRL in cats is imperative to inclusion of this drug in the chemotherapy arsenal for cats. Furthermore, results of this prospective phase I clinical trial will provide a basis for future efficacy studies. Based on our personal experience, cats treated with VRL at dosages of 8–9 mg/m2 have not experienced toxicity. Using this information to establish a starting point, our primary endpoints were to determine the maximum tolerated dose (MTD) and DLT of VRL in a population of tumor-bearing cats, while maintaining maximal dose intensity in each individual cat.
Materials and Methods
Patient Selection
Cats with confirmed malignancy, receiving ≥1 VRL treatment, and undergoing adequate follow-up to assess toxicity, were eligible for inclusion in this prospective phase I clinical trial performed between March 2009 and September 2012. Owners were required to sign informed consent, and the protocol was approved by the Institutional Animal Care and Use Committee at the University of Georgia. Seventeen cats were treated at the University of Georgia, College of Veterinary Medicine, Athens, GA, 1 was treated at the University of Wisconsin, School of Veterinary Medicine, Madison, WI, and 1 was treated at Veterinary Medical Specialists, Concord, CA. Previous treatment was acceptable, but concurrent radiotherapy or chemotherapy was not permitted. Cats historically treated with radiotherapy, chemotherapy, or both were required to undergo a treatment washout period of ≥3 weeks before entering the study. Concurrent prednisone was allowed if indicated by the specific type of cancer, but a 72-hour washout period for nonsteroidal anti-inflammatory drugs was required before trial initiation. Required preliminary staging tests included complete blood count (CBC), serum biochemical profile, urinalysis, and histologic or cytologic confirmation of malignancy. Blood urea nitrogen (BUN) >60 mg/dL, serum creatinine concentration >3.0 mg/dL, total serum bilirubin concentration >0.5 mg/dL, debilitating concomitant disease, expected survival <4 weeks, and a modified Eastern Cooperative Oncology Group (ECOG) performance score >1 were exclusion criteria. Additional diagnostic evaluations such as imaging tests, T4, and FeLV/FIV serology were performed at the discretion of the attending clinician, but were not required as part of the study.
As defined by the study, VRL1 was diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval was 7 days for up to 4 treatments. After receiving 4 weekly doses, cats were eligible to continue VRL treatment every 2 weeks at the owner's expense (Table 1).
|Week 1
|Week 2
|Week 3
|Week 4
|Week 5a
Using a modified conventional 3 + 3 phase I trial design,[12] patients were enrolled in cohorts of 3 per starting VRL dosage. Starting dosage cohort was defined as the cohort to which the cat was assigned at trial enrollment, independent of subsequent dosage escalations or reductions. The first cohort was treated at a starting dosage of 9 mg/m2. Dosage escalations of 1 mg/m2, up to 11 mg/m2, and 0.5 mg/m2 thereafter were permitted in the absence of DLT. If a DLT occurred within a starting dosage cohort, an additional 3 cats were enrolled in that specific cohort. The MTD was defined as the dosage at which <33% of cats experienced DLT, after treating at least 6 cats in the cohort in which toxicity occurred. Cats experiencing DLT were allowed to continue the treatment schedule once toxicity resolved, but future dosages were decreased by approximately 10%. This fixed rate of dosage reduction was 1 modification of the conventional 3 + 3 design.[12] A 2nd modification permitted intrapatient dosage escalation according to the aforementioned schedule in the absence of DLT in that individual and if the owner was willing. Continued dosage escalation in individual cats tolerating VRL beyond the MTD also was allowable as a final modification. The latter 2 modifications were made in an attempt to maximize individual dose intensity.
Cats were eligible to receive VRL every 7 days until disease progression, withdrawal from the study, or 4 weekly doses were given. Once off-study, cats were allowed to continue VRL every 14 days or to undergo other treatments as indicated by their specific cancers.
Toxicity Assessment
Drug tolerability was assessed by patient history, physical examination, and laboratory results (Table 1). Patients were required to have a modified ECOG performance score of <1, a neutrophil count ≥1,500 cells/μL, and a platelet count ≥50,000 cells/μL for treatment. Toxicities were characterized according to the Veterinary Cooperative Oncology Group Common Terminology Criteria for Adverse Events (VCOG-CTCAE),[13] and DLTs were defined as any grade 3 to 5 toxicity. Although grade 4 to 5 generally is considered dose-limiting for myelosuppression, any grade 2 to 4 neutropenia resulted in dose delay, and was thereby considered dose-limiting for this weekly protocol.
Response and Follow-Up
Response was not a primary endpoint, but cats with measurable disease were evaluated for response using Response Evaluation Criteria in Solid Tumors (RECIST) criteria.[14] Tumor measurements and imaging were performed at each visit and every 4–12 weeks, respectively, for the duration of VRL treatment. For patients off-study, follow-up information was obtained by phone communication with the owner or referring veterinarian. For cats dying while on study or within 1 month of going off study, dates and causes of euthanasia were recorded. Postmortem examination was offered, but not required as part of the study.
Nineteen cats were included in this study. Patient characteristics are summarized in Table 2. The number of cats enrolled per starting dosage cohort and total treatments given per dosage are summarized in Tables 3, 4, respectively. Starting VRL dosages were 9–12 mg/m2. Maximal dosage administered was 15.5 mg/m2. The MTD was 11.5 mg/m2. Dosages were de-escalated twice in 2 cats because of recurring episodes of neutropenia and once in 2 cats because of persistent vomiting.
|Median age (years)
|13 (range, 5–18)
|Median body weight at enrollment (kg)
|4.25 (range, 1.92–7.24)
|Female spayed
|Male neutered
|Maine coon
|Mammary CA
|Pulmonary CA
|Malignant cutaneous melanoma
|Intestinal MCT
|Intestinal ACA
|Nasal CA
|Salivary gland CA
|STS (non-ISS)
|Intestinal MCT + dermal HSA
|Starting Dosage Cohort
|Number of Cats Treated
|9 mg/m2
|10 mg/m2
|11 mg/m2
|11.5 mg/m2
|12 mg/m2
|Total Number of Doses Given
|9 mg/m2
|10 mg/m2
|11 mg/m2
|11.5 mg/m2
|12 mg/m2
|12.5 mg/m2
|13 mg/m2
|13.5 mg/m2
|14 mg/m2
|14.5 mg/m2
|15 mg/m2
|15.5 mg/m2
The DLTs included neutropenia, vomiting, and acute renal injury. None of the cats experienced more than 1 DLT. Three cats experienced dose-limiting neutropenia at 12 mg/m2. One developed grade 2 neutropenia at 12 mg/m² and was withdrawn from the study at the owner's request. One developed grade 3 neutropenia after the 1st treatment, resulting in dose delay. This cat's neutrophil count normalized within 7 days, and the cat was de-escalated to 10.8 mg/m2. Interestingly, grade 4 neutropenia was noted 7 days after treatment at the de-escalated dosage, and again resolved. The VRL dosage again was de-escalated by 10% to 9.25 mg/m2. This cat received 2 treatments at this dosage at weekly intervals and only grade 1 neutropenia was noted. The 3rd cat developed fever and grade 4 neutropenia after its 2nd weekly treatment at 12 mg/m2 and was hospitalized. The cat improved with IV fluids and antibiotics and was discharged from the hospital. However, despite normalization of the neutrophil count and resolution of fever, the cat continued to have decreased appetite and activity. Abdominal ultrasound examination was performed, and pancreatitis was diagnosed. In retrospect, it was difficult to determine if the fever was related to the neutropenia caused by the VRL, if the VRL caused the pancreatitis, or if the pancreatitis contributed to the fever and protracted clinical recovery. This cat intermittently had clinical signs associated with pancreatitis before starting VRL, thus the pancreatitis was thought to be unrelated to treatment and the concomitant inflammatory condition presumably played a role in what was perceived to be a septic event. After this event, the cat was withdrawn from the study by the request of the owner.
A 4th cat developed grade 3 neutropenia at 15.5 mg/m2. To maximize this cat's dose intensity, dosage escalation was continued beyond the MTD until DLT was noted. This cat was treated weekly up to 13.5 mg/m2 and then every 2 weeks up to 15.5 mg/m2. Its neutrophil count normalized within 7 days of the grade 3 neutropenia event. For the next treatment, the cat was de-escalated to 15 mg/m2, a dosage that had previously been tolerated without myelosuppression. Similar to the cat in the 12 mg/m2 cohort, grade 4 neutropenia was noted 7 days after treatment at this de-escalated dosage.
One cat in the 12 mg/m2 cohort experienced grade 3 vomiting, which started 3 days after the first VRL treatment. The dosage was decreased by 10% for the second treatment, but vomiting continued. Although this cat was being treated for metastatic intestinal mast cell tumor, a disease commonly associated with vomiting, the cat had no clinical signs before starting treatment. In fact, the mast cell tumor was an incidental finding during staging for dermal hemangiosarcoma. This cat received only 2 VRL treatments and was euthanized 15 days after enrollment in the trial. With this exception, vomiting was self-limiting to non-existent.
Finally, 1 cat experienced grade 4 acute renal injury at 12 mg/m². Two days after treatment, the cat was presented for weakness, decreased appetite, and polydipsia. It was clinically dehydrated and hypotensive (50 mmHg). BUN concentration was >100 mg/dL (reference range, 7.5–30 mg/dL) and serum creatinine concentration was 4.3 mg/dL (reference range, 0.6–1.2 mg/dL). These values had been 49 mg/dL and 1.5 mg/dL, respectively, with a urine specific gravity of 1.017 before VRL treatment. This cat was hospitalized and treated with IV fluids and gastroprotectants. Twelve and 36 hours after presentation, serum creatinine concentration was 4.6 mg/dL and 7.3 mg/dL, respectively. Because of the worsening azotemia, the cat was euthanized. At necropsy, widespread severe acute renal tubular necrosis, multifocal mild to moderate chronic tubulointerstitial nephritis and glomerulopathy were noted. This was the cat's 2nd VRL dose, and it tolerated the 1st treatment at 11.5 mg/m² well, experiencing only grade 1 anemia.
Another clinically relevant toxicity was weight loss. One cat in the 11 mg/m2 cohort and 2 in the 12 mg/m2 cohort experienced weight loss of approximately 10–14%. Weight loss generally was progressive over the 1st 3 weeks of treatment, but cats' body weights eventually stabilized. As defined by VCOG-CTCAE criteria[13] for constitutional signs, weight loss of 10–14% is considered a grade 2 AE, and by definition of our protocol was not considered dose-limiting. In contrast, under the heading of anorexia, weight loss ≥10% is considered a grade 3 AE and therefore would be dose-limiting. None of the owners reported anorexia, vomiting, or diarrhea to explain the weight loss, and admittedly 1 cat concurrently was receiving amoxicillin/clavulanic acid2 for a urinary tract infection, which may have contributed to weight loss in this cat. We ultimately deemed this AE as non–dose-limiting. Nevertheless, close monitoring of body weight during VRL therapy is warranted.
Other toxicities including grade 1 neutropenia, grade 1 to 2 vomiting, and grade 1 anorexia were uncommon and self-limiting when observed. Of note, however, was grade 1 to 2 anemia seen in 6 cats. Baseline hematocrit was within the reference range for all cats included in the study, and no particular dosage was correlated with the onset of anemia. Three cats received only 1 dose of VRL. The remaining cats received >1 dose, and anemia was noted after 3, 4, and 6 doses, respectively. Anemia resolved or improved in all cats with VRL delay or discontinuation.
Ten cats received VRL at dosages above the MTD, in part because intrapatient dosage escalation was allowed to maintain individual dose intensity. Five of these 10 cats experienced DLT at 12 mg/m2, and of these, 3 were in the 12 mg/m2 starting dosage cohort. Two cats continued treatment at 12 mg/m2 without further dosage escalation at the owners' request despite the fact that they did not experience DLT. Only 3 were escalated beyond 12 mg/m2. One of these 3 developed grade 4 thrombocytopenia at 13 mg/m2. One was escalated to 12.5 mg/m2, experienced no toxicity, but received no additional VRL treatments because this was the cat's 4th weekly dose. The 3rd cat was treated weekly up to 13.5 mg/m2 and then every 2 weeks up to 15.5 mg/m2. Grade 2 anemia (at dosages of >13.5 mg/m²) and the aforementioned grade 3 and 4 neutropenia (at 15.5 mg/m2 and 15.5 mg/m2, respectively) were the only toxicities this cat experienced.
Although 10 cats received <4 VRL doses, the majority were withdrawn from the trial for reasons other than toxicity. Three cats were withdrawn because of overt disease progression. Three cats were withdrawn to pursue other treatments for their individual cancers. One cat, treated elsewhere, was lost to follow-up 2 weeks after the first VRL treatment. One week after VRL treatment, the cat was examined by the attending oncologist and a CBC was performed. No adverse events were reported. Three cats were withdrawn from the trial because of toxicity, and of these, 2 ultimately were euthanized in part because of toxicity. Although the 3rd cat was withdrawn at the owner's request after experiencing grade 2 neutropenia, no other adverse events were noted. At last follow-up, 5 months after VRL discontinuation, this cat was still alive.
Response was not an endpoint of this study, and not all cats were evaluable for response. However, 1 cat with metastatic intestinal mast cell tumor experienced a durable partial response to VRL. In addition, 1 cat with metastatic pulmonary carcinoma experienced resolution of 2 lung nodules after 4 treatments of VRL.
Results of this prospective phase I trial demonstrate that VRL is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2. Dose-limiting toxicities were transient neutropenia, vomiting, and acute renal injury. Weight loss also was clinically relevant, and mild anemia was noted but not deemed dose-limiting. A small subset of cats tolerated incremental dosage escalations above the MTD. However, 2 cats were euthanized after treatment above the MTD. Although both cats had advanced cancers that may have contributed to their progressive clinical signs, we cannot entirely discount the possible role of VRL in the outcome of these cats. However, we believe its favorable toxicity profile at the MTD makes VRL a reasonable therapeutic option in cats with cancer.
All cases of neutropenia resolved before the next scheduled treatment, but 2 cats experienced worsening grades of neutropenia at de-escalated dosages. One possible explanation was that the neutropenia was a consequence of cumulative dosing and detrimental effects on the bone marrow. However, it was noted after the 1st 2 VRL doses in 1 cat. Alternatively, a double neutrophil nadir may have occurred. A double nadir previously has been reported in cats treated with CCNU,[15] and although not reported in the literature, we have seen the same effect in animals treated with carboplatin. The cause of this repeated neutropenia remains unclear, but it warrants further investigation because it was noted in more than 1 cat.
The acute renal injury was the most concerning AE. It was unclear if the clinical signs of dehydration and hypotension occurred first, possibly because of VRL treatment, and subsequently caused the acute renal injury, if the acute renal injury was a direct result of VRL nephrotoxicity, or if the event was completely unrelated. Unfortunately, necropsy did not answer this question because histologic changes were nonspecific and suggestive of severe acute tubular necrosis. Infiltrative disease, specifically renal metastasis was not noted. Although we were unable to find reports of VRL causing nephrotoxicity in humans or dogs, we could not exclude the possibility of its direct contribution to this AE.
Nephrotoxicity unique to cats has been noted with other chemotherapeutic agents. Both doxorubicin and liposome-encapsulated doxorubicin have been shown to cause subclinical to clinical nephrotoxicosis with histologic evidence of renal tubular injury in cats.[16, 17] Furthermore, renal injury associated with doxorubicin administration is thought to be a cumulative dosing effect. VRL may have a similar effect on feline kidneys and, if so, may only become clinically apparent in a subset of patients. Nephrotoxicity caused by other vinca alkaloids commonly used in cats has not been reported to our knowledge.
The weight loss noted was difficult to explain and its relationship to VRL was unclear. Associated gastrointestinal signs were not observed by owners, and none of the cats was known to have concomitant disease (eg, hyperthyroidism or clinically relevant renal failure) to explain the weight loss. Cancer cachexia was a consideration, but none of the cats experiencing weight loss had clinically relevant measurable disease. Although body weight eventually stabilized in each cat, none regained lost weight while receiving VRL.
Variations in interpatient drug tolerability were noted, and some cats experienced toxicity in the lower dosage cohorts, whereas others tolerated dosages above the apparent MTD. This was also observed in a phase I trial of VRL in dogs,[10] and it has been reported with other chemotherapeutics used in cats. In a phase I study of carboplatin, Kisseberth et al reported prolonged neutropenia and thrombocytopenia in some cats treated at dosages well-tolerated by other cats.[18] Henry reported substantial variability in the timing of neutrophil nadirs in healthy cats treated with the combination of mitoxantrone and cyclophosphamide.[19] Prolonged neutropenia, inconsistencies in the timing of neutrophil nadirs, and variability in interpatient tolerance all have been reported in cats treated with lomustine.[15, 20, 21] A plausible explanation for this variability in drug tolerance is differences in individual patient organ function and therefore drug metabolism and elimination. VRL is metabolized by the liver and excreted in the bile,[2] and renal insufficiency thus is unlikely to play a role in altered VRL elimination. Furthermore, in this study, no clear correlation between hepatic function and drug variability could be made. Finally, most cats experienced DLTs at 12 mg/m2. Regardless, more cats will need to be treated with VRL to answer this question.
Phase I dosage escalation trials are used to determine MTD, toxicities, and safe starting dosages of novel therapeutics. A traditional 3 + 3 design often employs a modified Fibonacci sequence in which the dosage escalation increment decreases as the total dosage increases and the suspected MTD is approached. This design was developed based on the assumption that toxicity and efficacy increase as the dosage increases, and it therefore preserves patient safety while minimizing the number of patients treated at subtherapeutic dosages.[12] An inevitable consequence of this design is that numerous dosage escalations generally are required before reaching the MTD.[12, 22] As a result, it is likely that a substantial number of patients is treated at subtherapeutic dosages.[12, 23] To overcome this consequence, this study employed several modifications to the traditional 3 + 3 cohort design.
One modification allowed for intrapatient dosage escalation. An advantage of intrapatient escalation is reduction in the number of patients ultimately treated at subtherapeutic dosages. Although some patients may start the trial at subtherapeutic dosages, they eventually escalate to more effective dosages. Another advantage is more rapid data accrual with fewer patients enrolled in the trial. This advantage is especially attractive in veterinary studies, which are often conducted with limited funding. On the other hand, a disadvantage of intrapatient dosage escalation is that it potentially limits the ability to detect certain toxicities and the dosages at which they occur. Furthermore, it becomes difficult to distinguish cumulative toxicities from delayed toxicities.[12]
A 2nd modification allowed for continued dosage escalation in individual cats tolerating VRL beyond the MTD. The approach was employed in attempt to maintain individual dose intensity. We recognized from the outset that some cats would tolerate VRL better than the overall population in general. We made this modification to avoid use of presumably subtherapeutic dosages in these individuals.
A final modification was use of a standard 10% dosage reduction rate for cats experiencing DLT as compared to de-escalation to the dosing cohort immediately below the cohort in which the DLT occurred (as employed in conventional phase I trials).[12] In our lower dosage cohorts (9–11 mg/m2), the 10% reduction approximated the conventional approach, as a cat with DLT at 11 mg/m2 was de-escalated by 10% to 9.9 mg/m2. However, as we approached the anticipated MTD and were escalating cohorts by only 0.5 mg/m2, we were concerned that such a modest dosage reduction would not substantially decrease the risk of repeated DLT. Although it remains unclear if this concern was valid, we observed repeated DLTs at de-escalated dosages in 3 cats (2 with neutropenia and 1 with vomiting) while using the 10% reduction rate.
Drug efficacy was not considered a primary endpoint of the study, but responses were seen in 1 of each of metastatic intestinal mast cell tumor and metastatic pulmonary carcinoma. Responses were based on imaging at baseline compared to imaging after 4 weekly VRL treatments using RECIST criteria.[14] Although these cancers are rare in cats, the data support phase II investigation of VRL for these cancers.
In conclusion, VRL appears well-tolerated in cats with cancer at a weekly interval and an MTD of 11.5 mg/m2. VRL should be considered part of the treatment repertoire for cats with cancer. With careful monitoring of clinical signs and hematologic variables, some cats may tolerate incremental dosage escalations beyond the apparent MTD.
The authors acknowledge Drs Cecilia Robat (University of Wisconsin) and Michael Kiselow (Veterinary Medical Specialists) for case contribution.
Funding for this study was provided by the University of Georgia Clinical Research committee.
Conflict of Interest Declaration: Authors disclose no conflict of interest.
- 1
Navelbine; Sagent Pharmaceuticals, Schaumburg, IL
- 2
Clavamox; Pfizer, New York, NY
- 1Advances in vinca-alkaloids: Navelbine. Nouv Rev Fr Hematol 1989;31:77–84., , , et al.
- 2Antimitotic drugs. In: Chabner B, Longo D, eds. Cancer Chemotherapy and Biotherapy: Principles and Practice. Philadelphia: Lippincott Williams & Wilkins; 2011:216–232..
- 3
- 4Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res 2000;60:5045–5051., , , et al.
- 5Pharmacogenetics in breast cancer therapy. Clin Cancer Res 2008;14:8027–8041., , , et al.
- 6Gemcitabine and vinorelbine combination is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT. Ann Hematol 2011;90:685–691., , , et al.
- 7Vinorelbine in cancer therapy. Curr Drug Targets 2012;13:1065–1071..
- 8Phase II trial of oral vinorelbine for the treatment of metastatic breast cancer in patients > or = 65 years of age: An NCCTG study. Ann Oncol 2006;17:623–629., , , et al.
- 9Gemcitabine in combination with vinorelbine in elderly patients with anthracycline- and taxane-pretreated metastatic breast cancer. Cancer Chemother Pharmacol 2012;69:1315–1322., , , et al.
- 10Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med 2004;18:536–539., , , et al.
- 11A phase II clinical trial of vinorelbine in dogs with cutaneous mast cell tumors. J Vet Intern Med 2008;22:388–393., , , et al.
- 12Dose escalation methods in phase I cancer clinical trials. J Natl Cancer Inst 2009;101:708–720., , .
- 13Veterinary cooperative oncology group – common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1. Vet Comp Oncol 2011;1–30; doi: 10.1111/j.1476-5829.2011.00283.x.
- 14New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228–247., , , et al.
- 15Phase II clinical evaluation of lomustine chemotherapy for feline vaccine-associated sarcoma. Vet Comp Oncol 2012;10:283–291., , .
- 16Hematologic toxicosis associated with doxorubicin administration in cats. J Vet Intern Med 1992;6:276–282., .Direct Link:
- 17Liposome-encapsulated doxorubicin (Doxil) and doxorubicin in the treatment of vaccine-associated sarcoma in cats. J Vet Intern Med 2002;16:726–731., , , et al.
- 18Phase I clinical evaluation of carboplatin in tumor-bearing cats: A Veterinary Cooperative Oncology Group study. J Vet Intern Med 2008;22:83–88., , , et al.
- 19Hematological and clinical responses to combined mitoxantrone and cyclophosphamide administration to normal cats: A correction. Can Vet J 1994;35:743..
- 20Phase I evaluation of CCNU (lomustine) in tumor-bearing cats. J Vet Intern Med 2001;15:196–199., , , et al.
- 21Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: Critical assessment of a practical dosing regimen. J Am Anim Hosp Assoc 2002;38:357–363., , , et al.
- 22Phase I trial design: Are new methodologies being put into practice? Ann Oncol 1996;7:561–566., .
- 23Early cancer clinical trials: Safety, numbers, and consent. J Natl Cancer Inst 1993;85:1618–1619..


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Wellness Program
Employee Gym
Spring Term hours are 8am-7pm Monday-Friday
The gym is located in the Anderson first floor former classroom, first door on your right, as you enter. There are treadmills, elliptical machines, a rower and bike, dumbbells and benches, lots of natural light, music and more. Locker rooms and towels too.
In addition, the College has arranged a discounted membership option with the 24 hour gym, Strength Beyond, located directly across Stadium Drive from the campus.
Strength Beyond discounted membership terms:
Prospective members sign up for a 12 month membership at $20 per month with no startup fees. You must contact the manager, Joshua Lillie, to receive this deal. Download the offer letter here. Visit their website here.
All wellness classes and services continue as usual, and while the wellness office is transitioning to Anderson as well.
Thank you for your patience as we evolve.
Click here to see building hours for Anderson and the Natatorium
Wellness Assessment and Coaching
Monthly Seminars and Workshops
Smoking Cessation
- Quitline A telephonic outreach program through the American Cancer Society
- Smokefree Online and telephone coaching resources from the U.S. Department of Health and Human Services
Pilates, Yoga, Circuit Training, Zumba
Family Swim - Academic Year: During the Sun Noon-4pm open swim. Pool toys in bin on deck.
Noon Walk Program - A guided, measured campus area walk for all fitness levels. Monday through Friday at noon, see Ken to begin.
Weight Training 101 - This is not a workout, but an instructional class to learn optimal technique for optimal benefit. Drop in, but limited to 10 people. Mondays 11-12 noon and Tuesdays 1-2 pm.


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Saturday 25th June 2016
Wedding Venue
Seagate Hotel
132 Pigiale Pasa Makenzi
tel:- 0030 24626210
web address:- www.seagatehotel.co.uk
e-mail:- email@example.com
Seagate Hotel :-
Hotel located in Larnaka
Wedding Trivia:BRIDAL SHOWERSBridal showers were meant to strengthen the ties between the bride and her friends, provide her moral support, and help her prepare for her marriage. Gift giving at showers dates from the 1890's.
More Wedding Venues
SWPP & BPPA, 6 Bath St, Rhyl, LL18 3EBTel 01745 356935International code (44)email@example.com © 2006-2012 SWPP. All rights reserved. - 02/02/2016 13:54:29


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Grey Africa produces moments that count for Consol [Campaign]Over the past few years Grey Africa has been an integral part of the team that has helped Consol Glass evolve from being merely a glass manufacturer to an interactive brand with a growing presence on social media and the ability to capture the ... The Marketing Site, 5 days ago
Marcum MicroCap Conference Showcases Technology, Biotech and Health and Wellness Companies
(Before It's News) Point Roberts, WA, June 13, 2016 Investorideas.com, a global news source and investor resource covering actively traded sectors reports on the recent 5th Annual Marcum MicroCap Conference held June 1- June 2, 2016, in New York ...Before It's News, 2 weeks ago
Navelim Villagers in quarters
NAVELIM: Navelim Villagers blanked Cuncolim Union 3-0 to move into the quarter-final of the SWC Zaino Soccer All -Goa football tournament played at Zaino,Velim ground on Wednesday. 19 May, 2016, 05:15AM IST Navelim Villagers started the match ...Goa Herald, 1 month ago
Koeman first target as Everton lose faith in Martinez
Everton will make Southampton's Ronald Koeman their prime target following Roberto Martinez's sacking. Martinez has paid the price for the club's poor Premier League campaign and the process of finding his replacement has -already begun. Koeman ...New Indian Express, 1 month ago
Michael Lee of Madam: are these the ten greatest creative directors ever?
Firstly, let's start with a question; what's the criteria for being a member of this rarified club? Here's my stab at it: The Creative Director was the very heart and soul of the agency. They were the one that every prospective client wanted to ...More About Advertising, 1 month ago
United SC edge past Mandopa SC to enter final
KAKODA: United Sports Club of Palolem got the better of Mandopa Sports Club 7-6 via the tie-breaker to move into the final of the 20th Holy Cross Cup, at Voilem Moll, Kakoda ground, on Tuesday. By Team Herald email@example.com | 04 May, 2016, ...Goa Herald, 1 month ago
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Superheros You'd Want To Rescue You
August 5th, 2011
Now these are the kind of costumed crusaders you would want around to save you from peril. Lets face it, it's a dangerous would out there and you'd need them close 24/7, even when you went to bed. Just to be 100% sure.
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What does NQDL stand for?
NQDL stands for New Queensland Drivers Licence (Australia)
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House speaker: Time running out for action on prison relocation
Jeffrey D. Allred, Deseret News
SALT LAKE CITY — House Speaker Becky Lockhart, R-Provo, said time is running out to deal with a bill creating a board to oversee the possible relocation of the Utah State Prison.
SB72 finally passed the Senate late Tuesday after a number of significant changes, including eliminating a six-month timeline for accepting bids to build a new prison and specific finance options for the project, estimated to cost between $550 million and $600 million.
The bill now gives the Prison Relocation and Development Authority, which has already endorsed moving the prison from Draper, the authority to evaluate bids and make recommendations to the Legislature.
With just over a week left in the session, Lockhart said Wednesday she had some concerns about how long it has taken the bill to get to the House and suggested it might be better left at this point for interim study and possible action in a special session.
"The Senate has had this piece of legislation for quite a while. They've been going over it and over it and over it," the speaker said. "It's a big commitment, and we try our best to have those big issues have as much time and as much input as possible."
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Robert Abbey has been designing and manufacturing fine lighting since 1946. They offer a diverse collection--wall swingers, chandeliers, floor lamps and more--in myriad styles, from tradition to neoclassical to groovy. Collaborating with acclaimed designers Jonathan Adler, Rico Espinet and David Easton, Robert Abbey creates impeccable lighting that is perfect for modern everyday living.
The Urania Crystal Table Lamp is available with the following:
- Flared White Mont Blanc parchment shade with Grosgrain trim
- Lead Crystal base with Silver Plated accents
- Silver finish
- Full range dimmer
- UL Listed
- One 100 Watt 120 Volt Incandescent lamp (not included).
Compare Brightness:
LumensThe amount of light that comes from a bulb, which has commonly been measured in watts. The more lumens, the brighter the bulb.
WattageA measurement of the power delivered to a component of an electric circuit (allowing a one-ampere current to flow through the component under the pressure of 1 volt.)
Bulb ShapeBulb shapes are denoted with a letter, which describes the shape, and a number, which indicates the size. The number indicates the diameter of the light bulb at its widest part in eighths of an inch.
BaseThe part of the bulb that connects to the fixture and its power supply. Bulb bases are denoted with the letter E, and a number which indicates the diameter of the bulb base at its widest part in millimeters.
VoltageIndicates how much voltage a bulb can accept via the fixture it's installed in.
Light Color TemperatureThe relative color from a light source, measured on the Kelvin temperature scale. Warm light is lower in color temperature (2700-3000 K) and cool, blue light is higher (5000 K).
Average Rated LifeThe average amount time that a bulb is expected to last.
CRICRI = color rendering index. This number, which can go from 0 to 100, measures the ability of a light or bulb accurately renders colors. The higher the number, the better, with most quality bulbs these days measuring at least in the 80s.
- Base Diameter 6":
- Fixture Height 33":
- Shade Height 9.5", Upper Diameter 6", Lower Diameter 10":
Manufacturer IDs: view
Need help with some of our terminology? Check out Lumens' Lighting & Design Glossary.
Related Searches and Products
The Robert Abbey Artemis Crystal Table Lamp blends form and fashion superbly into a glamorously modern lighting fixture. Smooth contours meet crisp edging on the lamp's body surface. The bold, clean lines of a Dupioni Empire Silk shade complement the ...
The dazzling style and luminous sensation of the Bling Buffet Table Lamp by Robert Abbey lives up to its name. The circular frame, ornamented with crystal Clear droplets, includes an adjustable switch. Bling's radiant halo is balanced with a resilient ...
The Addison Wide Table Lamp by Robert Abbey features beautiful vintage brass or patina nickel detailing with Opaque Parchment. An elegant rectangular fabric shade completes Addison's classic style, available in Taupe Dupioni,Pearl Dupioni or Painted Opaque black.
Lumens Recommends
72W 120V A19 E26 Clear Halogen Bulb (2-PACK)By Satco Lighting$6.99FREE VINTAGE STRING LIGHT KIT(1){boxId:"compareuu518423", id:"uu518423"} See Comparison


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The King of Queens 1998 | TV Show Watchlist
Season 2, Episode 17 Meet By-Product
First Aired: February 15, 2000
Doug and Carrie recall how they first met when he was a bouncer at a club and she was Richie's date. Donny Osmond appears as himself in a cameo. Lynn: Kara Zediker. Nicky: Laura Otis. Richie: Larry Romano. Doug: Kevin James. Carrie: Leah Remini.
Guest Cast
Donny Osmond Himself
Laura Otis Laura Otis Nicky
Jason Packham Jason Packham Patron
Kara Zediker Kara Zediker Lynn
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Wed Jun 29 11:00pm
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|By PR Newswire
Article Rating:
|January 11, 2013 11:27 AM EST
CHICAGO, Jan. 11, 2013 /PRNewswire/ -- Acquity Group (NYSE AMEX: AQ), a leading global Brand eCommerce® and digital marketing company, announced today it has appointed Andy Peebler as Executive Vice President, Global Sales. In his new position, Peebler will lead business development in North American and international markets as the company extends its offerings in strategic, creative and technical services groups.
With more than 15 years of experience in digital strategy development and over a decade at Acquity Group, Peebler's exceptional knowledge and experience helping global companies execute large-scale, omni-channel initiatives continues to play a vital role in some of the company's most profound growth in North America. As EVP of Global Sales, Peebler will oversee a growing team, currently comprised of more than 60 professionals, as the company strategically expands into new geographies.
"As we continue to build our business and make our mark in the digital services industry, we are formalizing a leadership structure that will enable us to effectively drive growth and evolve our offerings," said Chris Dalton, CEO of Acquity Group. "Andy's leadership and global focus will allow us to pursue worthwhile opportunities internationally and maximize customer, shareholder and employee value."
Previously EVP of North American Sales and Business Development at Acquity Group, Peebler was responsible for Acquity Group's first new market expansion in Phoenix, and subsequent launches on the West Coast, opening and growing five additional offices in Irvine, Los Angeles, San Francisco, Boise and Seattle. Throughout his tenure, Peebler built a national team that grew Acquity Group's business, including landing many major B2B and B2C client wins including HTC, American Express, Adobe Systems Incorporated and Shimano.
Over the last two years, Acquity Group has expanded into several new markets to meet increased demand for its unique Brand eCommerce® solution, which blends strategy, creative design, digital marketing and technology. Demand for Acquity Group's expertise is especially high among B2B companies pursuing digital initiatives that rival consumer experiences, a major growth area for the company.
About Acquity Group
Acquity Group is a leading global Brand eCommerce® and digital marketing company, creating award-winning digital experiences for global brands. Our multi-disciplinary approach brings together strategy, design, and technology to create unique brand experiences that build firm customer relationships. Acquity Group works with leading brands like Adobe, AT&T, General Motors, Motorola, and Saks Fifth Avenue through offices in North America and Asia. To define a unique perspective for your business, contact Acquity Group at www.acquitygroup.com.
Emily Johnson
Walker Sands Communications
(312) 267 2939
[email protected]
SOURCE Acquity Group LLC
When it comes to cloud computing, the ability to turn massive amounts of compute cores on and off on demand sounds attractive to IT staff, who need to manage peaks and valleys in user activity. With cloud bursting, the majority of the data can stay on premises while tapping into compute from public cloud providers, reducing risk and minimizing need to move large files. In his session at 18th Cloud Expo, Scott Jeschonek, Director of Product Management at Avere Systems, discussed the IT and busin...
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The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform and how we integrate our thinking to solve complicated problems. In his session at 19th Cloud Expo, Craig Sproule, CEO of Metavine, will demonstrate how to move beyond today's coding paradigm ...
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"My role is working with customers, helping them go through this digital transformation. I spend a lot of time talking to banks, big industries, manufacturers working through how they are integrating and transforming their IT platforms and moving them forward," explained William Morrish, General Manager Product Sales at Interoute, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
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The cloud market growth today is largely in public clouds. While there is a lot of spend in IT departments in virtualization, these aren't yet translating into a true "cloud" experience within the enterprise. What is stopping the growth of the "private cloud" market? In his general session at 18th Cloud Expo, Nara Rajagopalan, CEO of Accelerite, explored the challenges in deploying, managing, and getting adoption for a private cloud within an enterprise. What are the key differences between wh...
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The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, discussed how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He also discussed how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors ...
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"We work in the area of Big Data analytics and Big Data analytics is a very crowded space - you have Hadoop, ETL, warehousing, visualization and there's a lot of effort trying to get these tools to talk to each other," explained Mukund Deshpande, head of the Analytics practice at Accelerite, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jun. 29, 2016 04:15 PM EDT Reads: 361
SYS-CON Events has announced today that Roger Strukhoff has been named conference chair of Cloud Expo and @ThingsExpo 2016 Silicon Valley. The 19th Cloud Expo and 6th @ThingsExpo will take place on November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. "The Internet of Things brings trillions of dollars of opportunity to developers and enterprise IT, no matter how you measure it," stated Roger Strukhoff. "More importantly, it leverages the power of devices and the Interne...
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The idea of comparing data in motion (at the sensor level) to data at rest (in a Big Data server warehouse) with predictive analytics in the cloud is very appealing to the industrial IoT sector. The problem Big Data vendors have, however, is access to that data in motion at the sensor location. In his session at @ThingsExpo, Scott Allen, CMO of FreeWave, discussed how as IoT is increasingly adopted by industrial markets, there is going to be an increased demand for sensor data from the outermos...
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The initial debate is over: Any enterprise with a serious commitment to IT is migrating to the cloud. But things are not so simple. There is a complex mix of on-premises, colocated, and public-cloud deployments. In this power panel at 18th Cloud Expo, moderated by Conference Chair Roger Strukhoff, Randy De Meno, Chief Technologist - Windows Products and Microsoft Partnerships at Commvault; Dave Landa, Chief Operating Officer at kintone; William Morrish, General Manager Product Sales at Interou...
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Internet of @ThingsExpo has announced today that Chris Matthieu has been named tech chair of Internet of @ThingsExpo 2016 Silicon Valley. The 6thInternet of @ThingsExpo will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA.
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As organizations shift towards IT-as-a-service models, the need for managing and protecting data residing across physical, virtual, and now cloud environments grows with it. Commvault can ensure protection, access and E-Discovery of your data – whether in a private cloud, a Service Provider delivered public cloud, or a hybrid cloud environment – across the heterogeneous enterprise. In his general session at 18th Cloud Expo, Randy De Meno, Chief Technologist - Windows Products and Microsoft Part...
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Dialogic has announced that ZVRS chose Dialogic® PowerMedia™ XMS software media server as part of its latest video relay and translation service offering. ZVRS uses Dialogic's PowerMedia XMS technology to provide a robust solution that supports a broad range of legacy devices and any-to-any video capabilities with its flagship Z70 videophone. ZVRS selected Dialogic's solution to facilitate a release of Z70 that met its stringent requirements for legacy device support (H.263 and H.264) with high...
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Basho Technologies has announced the latest release of Basho Riak TS, version 1.3. Riak TS is an enterprise-grade NoSQL database optimized for Internet of Things (IoT). The open source version enables developers to download the software for free and use it in production as well as make contributions to the code and develop applications around Riak TS. Enhancements to Riak TS make it quick, easy and cost-effective to spin up an instance to test new ideas and build IoT applications. In addition to...
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In addition to all the benefits, IoT is also bringing new kind of customer experience challenges - cars that unlock themselves, thermostats turning houses into saunas and baby video monitors broadcasting over the internet. This list can only increase because while IoT services should be intuitive and simple to use, the delivery ecosystem is a myriad of potential problems as IoT explodes complexity. So finding a performance issue is like finding the proverbial needle in the haystack.
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You are moving to the Cloud. The question is not if, it's when. Now that your competitors are in the cloud and lapping you, your "when" better hurry up and get here. But saying and doing are two different things. In his session at @DevOpsSummit at 18th Cloud Expo, Robert Reeves, CTO of Datical, explained how DevOps can be your onramp to the cloud. By adopting simple, platform independent DevOps strategies, you can accelerate your move to the cloud. Spoiler Alert: He also makes sure you don't...
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Off the Hook : Fishing2
Rockyou Inc.
- April 4, 2012
( 946)
Top Developer
Enter the wildest fishing competition yet! Compete against the world's best for the biggest catch in up to 3 tournaments with 27 challenges! Cast your line in the Great Barrier Reef, Amazon, Loch Ness & more to reel in up to 28 kinds of fish, including Barracuda, Sharks & lots more! Brave a variety of tough weather and upgrade your bait & tackle to improve your luck in a quest to land the big one!
Compete in the wildest fishing competition yet!
Enter up to 3 tournaments with 27 challenges to fish against the best from up to 16 different countries
Cast your line in the world's best waters, like:
The Great Coral Reef, Amazon, Loch Ness and more!
Reel in up to 28 different types of fish, including:
Barracuda, Sharks, Triggerfish and much more!
Improve your bait, line and rod to catch more fish!
Use your skills to keep on fishing through tough conditions like rain, wind, nightfall & more!
What's up I put this game on my 5" screen and its fine. Now I put it on my new 5.5" phone and everything is so tiny I almost can't see the line. What's up with that
I'll give u 5 star if If the game more improvement rather than OTH java game version.im still play the game but different phone.on my asus zen5 the game look terrible bcoz its android version.2 yrs before,im play on sony elm and im really2 enjoy.i hope u can fixed this.
Hopelessly Poor! Digital Chocolate is a big name... It's dissapointing to see they r having a hard time figuring out how to fit the screen resolutions. Tis the first time I am noticing such a problem in any app. Now I know that even droid apps experience such problem, thanks for enlightening me... LOL... No change in the games from their java versions except the hopeless resolution bug ofcourse... Have they appointed lab monkeys as devs, coz 1st year interns would do much better... Digitals 'D' is for DISAPPOINTMENT...
GREAT GAME Very amazing game but can you add new updates and get rid of opponents getting big fishes and we can't its very annoying thanks
Resolution issue on my Nexus 6 Why is everything SO tiny? FIX IT! Gonna delete this if not.
Off the hook fishing Best and easiest fishing game I've ever played. I love it...Please make another one:-) Please with lots of sugar on it lol. I know I'm reading. If only my arms were a little bit longer
What's New
Bug fixes and general optimizations.
Cute animals, new missions and your own farm! What else do you need? Play now!


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InfoJobs.net Selects Red Hat and JBoss Solutions For Critical Business Platform
Red Hat today announced that InfoJobs.net, one of the leading employment websites in Spain, has migrated its critical web business platform to Red Hat Enterprise Linux and JBoss Enterprise Application Platform with the help of Essi Projects, a Red Hat Premier Business Partner.
Infojobs.net now fully leverages JBoss Application Platform 4.2.0 and Red Hat Enterprise Linux for its application servers, indexing subsystem and database servers. Established ten years ago, InfoJobs.net runs a high-traffic web portal and has experienced significant growth. More than 5,500 users register their curriculum vitae through the InfoJobs.net web portal each day. With over 100,000 employment vacancies listed, Infojobs.net must meet the high-volume demand required by its users. Because of Red Hat's significant value and fast run-times the IT department at InfoJobs.net migrated to Red Hat Enterprise Linux for all its environments and JBoss Enterprise Application Platform for its web and satellite servers.
"Red Hat and their partner, Essi Projects, provide the greatest value for our business model. They provide superior on-demand support which is exactly what we need," said Gabriel Prat, IT manager, InfoJobs.net.
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July 2016 issue of The PCLinuxOS Magazine releasedThe PCLinuxOS Magazine staff is pleased to announce the release of the July 2016 issue. With the exception of a brief period in 2009, The PCLinuxOS Magazine has been published on a monthly basis since September, 2006. The PCLinuxOS Magazine is a product of the PCLinuxOS community, published by volunteers from the community. The magazine is lead by Paul Arnote, Chief Editor, and Assistant Editor Meemaw. The PCLinuxOS Magazine is released under the Creative Commons Attribution- NonCommercial-Share-Alike 3.0 Unported license, and some rights are reserved. In the July 2016 issue: * Seven Years Later: A Look Back * Installing A Seeburg 1000 On PCLinuxOS * ms_meme's Nook: Anytime * PCLinuxOS Family Member Spotlight: tuxlink * GIMP Tutorial: Engraved Text * Game Zone: Funklift * PCLinuxOS Recipe Corner * Tip Top Tips: A Simple HTTP Server * PCLinuxOS Puzzled Partitions * And much more inside! This month's magazine cover image was designed by Meemaw. Download the PDF (8.3 MB) http://pclosmag.com/download.php?f=2016-07.pdf Download the EPUB Version (6.6 MB) http://pclosmag.com/download.php?f=201607epub.epub Download the MOBI Version (7.6 MB) http://pclosmag.com/download.php?f=201607mobi.mobi Visit the HTML Version http://pclosmag.com/html/enter.html
4MLinux 18.0 Distro Released with Support for LibreOffice 5.2, Thunderbird 45.1
4MLinux developer Zbigniew Konojacki has just informed Softpedia today, July 1, 2016, about the immediate availability for download of the final release of the 4MLinux 18.0 operating system.
GNU/Linux Leftovers
Leftovers: Ubuntu and Debian


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About سكسي اجنبي ليلة دخلة
سكسي اجنبي ليلة دخلة سكسي افلام كامله Then add the same thing on the vendors end -- optimizing their offers and creatives to the various publishers -- and the affiliate industry could be a major force for profits on the Web again. Reality sucks.
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