text:
|Publication number
|Publication type
|Application number
|Publication date
|Apr 17, 2001
|Filing date
|Aug 2, 1999
|Priority date
|Oct 20, 1998
|Fee status
|Publication number
|Eckhard Alt
|Original Assignee
|Inflow Dynamics Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Referenced by (91), Classifications (14), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation-in-part of U.S. application Ser. No. 09/175,919, filed Oct. 20, 1998, now U.S. Pat. No. 6,099,561 and U.S. application Ser. No. 09/259,906, filed Feb. 28, 1999, now pending of the applicant herein, and is assigned to the same assignee as each of those applications.
The present invention relates generally to stents which are implantable or deployable in a vascular or endoluminal location within the body of a patient to maintain the lumen open at that location, and more particularly to improvements in stent.
Stents are expandable prostheses employed to maintain narrow vascular and endoluminal ducts or tracts of the human body open and unoccluded, such as a portion of the lumen of a coronary artery after dilatation of the artery by balloon angioplasty. While vascular usage is frequently discussed in this application, it will be understood by those skilled in the art that stents having the characteristics and features of the present invention may be implanted in other ducts or tracts of the human body to keep the lumen open, such as in the cerebral circulation system, tracheo-bronchial system, the biliary hepatic system, the esophageal bowel system, and the urinary tract system
In the case of an occluded coronary artery, for example, the original blockage is typically attributable to fatty deposits or plaque on the inner lining of the vessel. A different mechanism, however, produces a new blockage after an angioplasty procedure is performed to compress the deposits against the inner lining of the vessel, as by use of balloon angioplasty, or to virtually entirely remove the deposits, as by use of laser angioplasty or rotational cutting. The blood vessel wall is subjected to trauma by any of these procedures, which results in hyperplasia of the neointima, i.e., a rapid proliferation of muscle cells in the affected region of the wall, to cause restenosis and re-occlusion of the vessel lumen in a significant percentage of angioplasty patients within a period of from three to six months following the initial procedure.
To avoid this re-occlusion and to maintain the lumen of the vessel open, it is customary procedure to install a stent at the site in the vessel where the angioplasty was performed. The stent is deployed by radial expansion under pressure exerted by the inflating balloon of a balloon catheter on which the stent is mounted, to engage the inner lining or surface of the vessel wall with sufficient resilience to allow some contraction but also to provide a degree of stiffness to resist the natural recoil of the vessel wall following expansion.
Trends and extensions of increased knowledge and methods in practical cardiology are based primarily on advances in basic science and applied technology. For example, ten years ago, treatment of myocardial infarction (GI) stressed limiting physical injury and damage and focused principally on rehabilitation. The treatment strategy for acute MI was followed by a period of use of a thrombolytic agent. New techniques, new catheters, new stents and guidewires and improved fluoroscopic x-ray machines have more recently enabled treatment of acute MI with interventional catheter techniques. In one of these techniques, involving an angioplasty procedure, a small guidewire is advanced through an occlusion of a coronary artery which is attributable primarily to a thrombus, a balloon catheter is then advanced along the guidewire, and the balloon is inflated at the site of the thrombus to open the lumen of the artery. A stent is deployed at the lesion site either concurrently with or immediately following the angioplasty procedure to provide the necessary mechanical support to hold the lumen of the dissected vessel wall open.
This technique has been applied very successfully in coronary vessels which have a range of diameters from approximately 2.5 to 3.5 millimeters (mm). However, present day successful treatment of vessels having diameters smaller than 2.5 mm remains quite limited, because currently available apparatus and stent delivery systems are inadequate to negotiate such small vessel sizes to allow installation therein.
A wide clinical spectrum of diseases exists that would be receptive to beneficial treatment of vessels smaller than 2.5 mm in diameter. One such instance is treatment of side branches of the coronary arteries, which has a beneficial indication. A capability to treat vessels other than coronary vessels but of similarly small diameter, such as vessels enabling blood circulation in the brain, would likewise be desirable.
Ischemic stroke is characterized by pathophysiological characteristics which are very similar to those of MI. An artery is occluded either by an embolized thrombus as in patients with atrial fibrillation, or by a local thrombus that builds up on an arteriosclerotic vessel wall. Often these arteriosclerotic vessels are undergoing a local dissection, which limits the blood flow and activates the coagulation system. Access to small occluded arteries of the brain or other parts of the body for implementing procedures to allow adequate blood flow therethrough is a highly desirable objective for treating millions of persons likely to suffer stroke each year.
One of the technical prerequisites for successful treatment in these respects is the availability of a stent, and related delivery system, which is sufficiently small and thin that it can navigate and be and deployed in these tiny vessels without occluding the lumen thereof It is also essential that the stent be highly visible during and after implantation to enable proper deployment and aftercare by the physician. The latter attribute is especially important for treatment of intracerebral arteries, because of the obstacle to x-rays presented by the skull which makes precise visualization of a small thin stent extremely difficult. The stent should, therefore, be sufficiently radiopaque for valization without need for its struts to be made so large that the stent itself creates an unacceptable obstruction of the lumen of the vessel.
Another prerequisite of a successful treatment of these extremely small diameter vessels is that the stent delivery system should be highly flexible to allow it to be advanced along the anatomy of the cerebral circulation.
In addition, the total stent delivery system must be of extremely small profile, which will allow vessels of 2.0 mm, 1.75 mm or even 1.50 mm diameter to be addressed. No currently available stent delivery system has a balloon with a diameter less than about 2.5 mm when inflated at nominal pressure.
Therefore, it is a principal aim of the present invention is to provide stents and stent delivery systems having such attributes and characteristics, so as to enable successful treatment of extremely small diameter blood vessels and other ducts, tracts or conduits of the human body, without unacceptable obstruction of the vessel lumen itself.
According to the present invention, a stent and a stent delivery system are provided with features and characteristics which will allow the stent to be premounted on the balloon of the delivery system for easy introduction into and advancement through vessels having diameters in a range from about 1.25 to less than 2.5 mm. The solution to achieving these ends lies in implementing a suitably small-sized stent.
It is crucial in the case of a very small-sized stent, as with the present invention, that there be sufficient retention force between the stent and the balloon that the stent will be maintained in place on the balloon. This retention must exist throughout travel of the stent, so as to avoid having the stent dislodged from the balloon during navigation of the delivery system through the vessel. At the same time, the stent must—despite its small crossing profile which will avoid innate obstruction of the vessel lumen—possess sufficient mechanical strength to support the vessel wall at a target site where it will be deployed. Further, it must resist the natural recoil of the vessel wall which inevitably follows deployment of the stent.
Added to these prerequisites is the further need to maintain sufficient visibility of such a small-sized stent that the implanting physician is able to properly place the stent for deployment to successfully carry out the procedure.
Ordinarily, for mounting or premounting, the stent is crimped onto the balloon under external pressure. Consequently, the mesh structure of the stent undergoes considerable deformation during the crimping procedure, which takes two individual and distinct forms. First, the stent undergoes an elastic deformation in response to the external pressure applied to crimp it to a smaller diameter. In this type of deformation, the stent assumes a new shape but, because of its elastic properties, seeks to return to its former shape—even if only slightly—when the external pressure is removed. Second, the stent undergoes plastic deformation which tends to maintain the new shape that resulted from the external pressure of crimping. The greater the plastic deformation compared to the elastic deformation—i.e., the higher the ratio of the former to the latter—the higher is the retention force exerted by the stent on the balloon. As noted above, maximizing or optimizing this retention force is an important aspect of the invention.
Another important consideration in implementation of an embodiment of the present invention is the reduction of outside or exposed surface area of the balloon used in the stent delivery system, that occurs with reduction of the balloon diameter to accommodate a much smaller stent than is ordinarily encountered. For the small stent size of the present invention, the uninflated balloon diameter preferably ranges from about 0.5 to about 1.0 mm, and more preferably from about 0.5 mm to about 0.8 mm. The resultant relatively small outside surface area of the balloon has a further deleterious effect on retention force exerted by the stent when mounted in crimped fashion on the balloon.
Therefore, it is another important aim of the present invention to provide a premounted stent delivery system suitable for traversing body vessels, ducts or tracts having lumen diameters in a range from about 1.25 mm to less than about 2.5 mm, in which the stent exhibits a very high retention force despite the small diameter of the stent and the delivery system balloon and the relatively small outer surface area of the balloon.
According to the invention, the stent is provided with a rough surface characteristic, rather than a smooth surface as is typical for stents, and this rough surface characteristic or feature significantly increases the retention force of the stent on the balloon. A coating material is applied whose inherent material characteristics serve to increase the surface structure and area of the basic stent to which it is applied or on which it is formed. Such a surface characteristic is provided, for example, by the techniques and methods described in co-pending U.S. patent applications Ser. No. 09/059,053 and Ser. No. 09/175,919 of the applicant herein, assigned to the same assignee as the present application. The finished stent has a multi-layer surface region, the outer layer being a ceramic-like material with a relatively rough external surface. This outer layer is biocompatible and may be very thin, with the composition of a compound or derivative of certain metals such as iridium oxide (sometimes referred to herein as "IROX") or titanium nitrate. The outer layer overlies the entire exposed surface of the stent, so that when the stent is mounted on and crimped against the balloon of the stent delivery system, the rough surface structure of the stent lumen resides directly against the outer surface of the balloon along the area of contact. The surface roughness, however, is not so extreme as to potentially puncture the balloon. Creation of a rough surface may be achieved by a number of alternative techniques, beyond those disclosed in the aforementioned '053 and '919 applications, examples of which will be described in the detailed description below.
In a preferred embodiment, the multi-layer stent is composed of three different layers including an innermost tubular core, an intermediate corrosion-resistant layer overlying the core material, and the aforementioned thin ceramic-like metal or derivative thereof outer layer overlying the intermediate layer and providing the rough surface characteristic of the overall stent. In an exemplary embodiment, the core material is medical grade stainless steel, the intermediate layer is gold, and the outer layer is IROX. It is important that each of the intermediate and outer layers tightly adhere to its respective directly underlying layer material. Tight adherence of the gold coating to the underlying steel core may be achieved, for example, by a process described in U.S. Pat. No. 5,824,045, which is assigned to the assignee of the present application. The noble metal layer (e.g., gold) aids both in keeping the total thickness of the stent relatively small, while considerably enhancing the visibility of the stent on x-ray fluoroscopy over the visibility of a correspondingly thin layer of steel, for example, to aid the implanting physician in guiding the stent to and deploying it at a desired target site in the vessel.
The core material of the stent is generally constructed of an elongate biocompatible metal member composed, for example, of 316L stainless steel (medical grade), but may alternatively be composed of other biocompatible material such as titanium, Nitinol (nickel-titanium alloy with shape memory characteristics), iridium, or other metal, which is configured in an open-ended tubular or cylindrical shape (e.g., coil, mesh, undulating single wire filament or perforated tube). For convenience, the portion of the stent between its open ends is referred to herein as the sidewall, regardless of the particular tubular shape of the structure, and as having openings therethrough even though a coil stent has only one continuous spiral opening in its sidewall and a continuous filament wire may have very large openings in its "sidewall."
When mounted on the balloon, the stent of the present invention is of sufficiently small diameter—with a total crossing profile of from 0.5 to 0.8 mm, depending on final size—to be accommodated by and to readily traverse a vessel, tract or other duct of patient's body less than 2.5 mm in diameter, and optimally between 1.25 mm and 2.5 mm, to the site at which the stent is to be deployed. The rough outer surface of the stent serves to increase the retention force of the stent when crimped on the balloon, for secure retention of the stent and ease of navigation of the stent delivery system through the vessel. Deployment is achieved by controlled inflation of the balloon of the stent delivery system to apply a uniform radial outwardly directed force on the sidewall of the stent to increase its diameter, and thereby expand or open the stent until it is in firm contact or engagement with the inner lining of the vessel wall, for retention at that site. The mechanical strength of the stent should be adequate to resist collapse from the natural recoil of the vessel wall when the balloon is deflated and the delivery system is withdrawn from the patient's body.
Thus, despite a smaller area of contact between the stent and the balloon of the delivery system, a high retention force is created as a consequence of the increased friction between them owing to the relatively rough surface of the stent. There is no need for taking special pains for fitting or aligning components or for increasing the diameter (which could defeat the desire to navigate the small-sized vessels), and even balloons that are normally used solely for balloon angioplasty will suffice for use as the balloon of the stent delivery system.
Another problem typically encountered in stent delivery systems sought to be used in small-sized vessels is that the sidewall thickness of the stent has been made relatively large in an effort to achieve improved retention force on the balloon. But a large wall thickness undesirably reduces the lumen diameter of the vessel at the site of deployment of the stent. For to example, in a vessel of 1.50 mm lumen diameter, a stent with a wall thickness of 0.125 mm results in a lumen diameter reduction of 0.25 mm, i.e., a loss of almost 17% in total lumen diameter. In the stent delivery system and method of the present invention it is possible to use a stent having a wall thickness of much smaller dimension—in a range on the order of only 50 microns (micrometers, or μm) to 75 μm—and thereby, with considerably less adverse effect on vessel lumen diameter. This is because the increased friction attributable to the rough surface of the stent compensates for the lower retention force attributable to the reduced sidewall thickness of the stent.
The above and still further aims, objectives, features, aspects and attendant advantages of the present invention will become apparent from the following detailed description of preferred embodiments and methods of manufacture and usage of a stent and a delivery system on which the stent is premounted, constituting the best mode presently contemplated of practicing the invention, when taken in conjunction with the accompanying drawings, in which:
FIGS. 1 and 2 are, respectively, a perspective view of an embodiment of a vascular or endoluminal stent having a rough surface structure according to the present invention, and a relatively enlarged partially-processed fragmentary portion thereof; and
FIG. 3 is a cross-sectional view of a three-layer preferred embodiment of the stent of FIG. 1.
Each of the '919 and '906 applications is incorporated in its entirety into this specification by reference. Nevertheless, for the sake of convenience to the reader, certain portions of the two co-pending applications will be repeated in some detail herein.
In FIG. 1 (not to scale) stent 10 is fabricated as a hollow tubular self-supporting structure or member 11 composed of a biocompatible metal such as medical grade 316L stainless steel, although other metals may alternatively be used, such as titanium, iridium, or Nitinol, for example. The tubular member is provided with a multiplicity of through-holes or openings 12 through sidewall 15, defined and bounded by a plurality of struts or links 13, which enables expansion of the stent diameter when the device is to be deployed at a target site in a vessel, duct or tract of the human body. The openings 12 may be precisely cut out to form a latticework sidewall using, for example, a narrow laser beam following a programmable pattern. The removed material is discarded.
By way of example, the resulting pattern in the latticework sidewall 15 is a network of interconnected struts 13 which are optimized for orientation predominantly parallel to the longitudinal axis 16 of the tube 11, with none of the struts oriented perpendicular (i.e., transverse) to the axis 16, so that no strut interconnecting any other struts in the latticework is oriented to lie completely in a plane transverse to the longitudinal axis, without running from one end of the stent to the opposite end. This structure, described in detail in applicant's copending application Ser. No. 08/933,627, also incorporated by reference in its entirety herein, provides a very low friction characteristic (or coefficient of friction) of the outer surface 17 of the stent, to ease advancement of stent 10 in a vessel, duct or tract to a site for deployment.
The network or latticework of struts 13 defines a series of longitudinally repeating circumferential rows of openings 12. Each pair of struts such as 21, 22 bounding an opening 12 in any given row 25 are in the shape of circumferentially displaced wavelets with adjacent circumferentially aligned higher and lower crests 26, 27, respectively, in which the wavelets intersect (30) one another at one or both sides of the crests (30, 31). The intersection 30 of struts (or wavelets) at one side of the adjacent circumferentially aligned crests 26, 27 of row 25 is tangential to a crest 33 of the immediately adjacent row 35, and the intersection 31 of struts (or wavelets) at the other side of those crests is tangential to a crest 37 of the immediately adjacent row 38. Interconnecting points such as 40 between the struts may be notched to enhance symmetrical radial expansion of the stent during deployment thereof
When the stent 10 is crimped onto a small diameter (low profile) delivery balloon (not shown), the adjacent circumferentially aligned crests of each row move closer together, and the pattern formed by the latticework of struts allows substantial nesting together of the crests and bows, which assures a relatively small circumference of the stent in the crimped condition. This stent is highly flexible, and is capable of undergoing bending to a small radius corresponding to radii of particularly tortuous coronary arteries, without permanent plastic deformation.
As the stent 10 is partially opened by inflation of the balloon during deployment, the adjacent crests begin to separate and the angle of division between struts begins to open. When the stent is fully expanded to its deployed diameter, the latticework of struts takes on a shape in which adjacent crests undergo wide separation, and portions of the struts take on a transverse, almost fully lateral orientation relative to the longitudinal axis of the stent. Such lateral orientation of a plurality of the struts enables each fully opened cell to contribute to the firm mechanical support offered by the stent in its fully deployed condition, to assure a rigid structure which is highly resistant to recoil of the vessel wall following stent deployment. It bears emphasis, however, that the configuration of this stent structure, while highly desirable, is illustrative only and not essential to the principles of the present invention.
The tubular steel core sidewall 15 of the stent is coated with a thin, tightly adherent layer 50 (FIG. 2, a fragmentary perspective view shown partly in section for clarity) of noble metal, preferably gold, but alternatively an alloy which is primarily composed of gold or other noble metal. The gold layer is applied to cover the entire exposed surface of the basic metal stent, whether of the type shown, or a metal mesh, or other configuration. This is preferably but not necessarily achieved by a method described in the aforementioned '045 patent, which is incorporated in its entirety herein by reference. Preferably, this layer has a thickness in a range from 1 μm to 10 μm, and more preferably about 5 μm.
According to the latter patent, the thin adherent film or layer 50 of gold is applied by a process of ion beam deposition to provide a firm, tightly bonded, extremely thin foundation layer, which allows the bond between base metal and noble metal to flex without suffering fracture or peeling of the overlying layer. This initial foundation layer is built upon preferably by a conventional galvanic process by which one or more additional thin, tightly adherent uniform layers of gold are applied, to form an overall composite layer of gold having a thickness of from about 3 μm to about 6 μm, and preferably about 5 μm, on each side of the wall of the stent. The overall effect of these processes is a layer adherence that precludes cracking, peeling or flaking of any portion of the overall gold layer from the underlying surface of the steel core, which might otherwise occur during times when the stent is undergoing mechanical stress and distortion, such as during pre-opening, crimping, and expansion-during deployment phases of the procedure.
Stent 10 preferably is composed of three different primary or fundamental layers as shown in the greatly exaggerated fragmentary cross-sectional view of FIG. 3, taken through the line 3—3 of FIG. 1. By "primary" and "fundamental", as used here, it is meant that although the stent may have additional layers, coatings or films, the three layers—two of which have been described thus far—are important to the favorable characteristics enjoyed by the stent.
The third or upper or outermost layer 80 is preferably composed of a ceramic-like metal material such as either iridium oxide (IROX) or titanium nitrate, these materials being exemplary of a biocompatible layer that serves a primary purpose of avoiding tissue irritation and thrombus formation. This outermost layer may be deposited as an inert coating over the surface(s) of the underlying intermediate noble metal layer by any known method, preferably to a thickness in the range from about 500 nm to about 1,500 nm (=1.5 μm). This outermost layer is also preferably applied to all exposed surfaces of the wall of stent 10, so it is the surface that contacts both the inner lining of the vessel and the blood flowing through the lumen of the vessel in which the stent is implanted (deployed).
In addition to assuring the absence of a galvanic potential that could cause corrosion of the base layer, the intermediate noble metal layer serves to enable flexing of the stent over a vast number of cycles encountered in actual use without loss of the overlying rough surface coating (outermost layer) from flaking, shedding or disintegration.
A high voltage sputtering process is among many suitable processes that may be used to form this outermost rough surface coating. Others include anionic oxidation, thermal oxidation, sintering, and electrodeposition. Oxalic acid, application of current and heat, and additional use of an ultrasound bath have been found to produce a very tight adhesion of iridium oxide to the underlying intermediate layer. Suitable processes for forming iridium oxide or titanium nitrate layers also have been developed and can be performed by Hittman Materials & Medical Components, Inc. of Columbia, Md., for example. In any event, the outermost layer 80 is formed with a relatively rough surface, for purposes of providing the increased friction factor and retention force according to the present invention.
A three layer stent structure can be produced with an overall thickness in a range from about 50 μm to about 75 μm. The stainless steel wall may be fabricated in a thickness of approximately 45 to 60 μm, which offers sufficient mechanical strength to resist the natural recoil of the blood vessel wall following deployment of the stent. The gold intermediate layer is applied in a 5 μm thickness, for example, to all exposed surfaces of the base layer, giving a total additional thickness of about 10 μm to the structure, and serving to avoid a galvanic potential. The outermost layer of iridium oxide is formed to a thickness preferably in a range from 500 nanometers (nm) to about 1.0 μm.
The most preferred method of producing the outermost stent coating of iridium oxide is described in detail in the '906 application. Briefly, the method employs a combination of a chemical bath process together with application of heat and mechanical forces. An ultrasonic water bath is maintained at a preselected water temperature according to the setting of a thermostat. Initially, the surface of each stent to be coated is prepared by activation. For a gold-coated stent with a base or core metal of medical grade stainless steel, iridium, titanium or Nitinol, for example, adequate surface activation is achieved by immersing the stent in a solution of 10% oxalic acid at a temperature of about 100� C., for a period of about 30 minutes. The stents are then thoroughly rinsed with distilled water and dried in air at a laminar flow at room temperature. Each stent is then inserted into a respective glass vial for the coating process, and the vials are then inserted into respective holders of a tray or trays for partial submergence in the water bath.
A quantity of coating solution is added to the vial sufficient to cover the stent. The coating solution is prepared by dissolving 200 milligrams (mg) of iridium chloride in 5 ml of 20% hydrochloric acid, in a separate reaction beaker, then boiling slowly at approximately 100� C. until the solution is evaporated to approximately 20% of its original volume, e.g., from 5 ml to one ml. Although the coating solution may be stored, it is preferably used within seven days after having been prepared. 500 microliters (μl) of coating solution was found to be sufficient for full coverage of the stent for a vial with a liquid content capacity of one milliliter (ml), but the amount of coating solution to be added to a vial for a particular stent will depend on and be adjusted according to the size and surface dimensions of the stent to be coated. Each vial is closed with a stopper having a tiny hole for pressure relief during operation of the bath.
In the bath, the vials are arranged in the holder such that each is upright and the entire stent lies completely below the bath water level. In an exemplary operation of the bath, the ultrasonic generator delivered a mean energy of 320 watts at a frequency of 35 kiloHertz (kHz). The vials and stents undergo vibration at that frequency, and the water bath undergoes heating up to the preset temperature, which is maintained by virtue of circulating coolant water at the exterior of the bath, while continuously maintaining the ultrasonic vibrational energy for adherence of the coating.
During the ultrasonic bath operation, the iridium chloride in the coating solution substantially uniformly coats the submerged stent with a layer of iridium chloride, which is ultimately converted to iridium oxide during retention of the vials in the bath in the presence of heat, ultrasonic energy, and air. Any molecular bound water leaves the crystal structure of the iridium oxide following the heating.
After a period of time—at least about 6 hours of bath operation in an exemplary procedure—the vials are removed from the bath, and the stents are then removed from the vials, rinsed with de-ionized pure water, and dried in a laminar flow of air for about one hour at room temperature. This is followed by heating the coated stents in an oven for about 12 hours at a temperature of 320� C. The heating converts any residual iridium chloride in the coating to iridium oxide, so as to create the final complete iridium oxide coating. Then the stents are cleaned ultrasonically and with alcohol in a manner which is customary for biomedical implants.
Stents averaging 16 mm in length, with a diameter suitable for mounting on an uninflated balloon of a diameter from about 0.5 to 1.0 mm and a strut thickness of from about 50 to 75 μm underwent a slight increase in weight which depended on the desired coating thickness. A coating thickness ranging from about 500 nm to about 1 micron maybe optimum.
Tests conducted on stents coated by this method including vibrational, ultrasonic, bench and maximum expansion/repeated crimping tests—have demonstrated that the iridium oxide is firmly attached to the underlying base or core metal of the stent, so this outer layer will neither flake off nor disintegrate from the stent even with maximum expansion during subsequent implantation and deployment. It is believed that by the continuous application of ultrasonic energy in the coating method, only those iridium oxide molecules that attach to the underlying base metal enter into a very firm bond, while the other molecules are removed from the stent and, with the ultrasonic induced vibration, are dissolved in the prepared solution.
The thickness of the iridium oxide layer which is formed on the base metal of the stent, and the roughness of its exposed surface, are controlled by appropriate variation of the iridium compound and its amount and concentration in the prepared solution, as well as by the characteristics of the ultrasonic bath. A relatively rough outer surface on the firmly bonded iridium oxide layer, and thus of the overall stent itself provides numerous indentations.
The rough outer surface serves to increase the coefficient of function and the retention force of the stent when mounted on a balloon for implantation in a small-sized vessel of the human body. A considerable risk exists that a balloon catheter-mounted stent might be dislodged from the uninflated or partially inflated balloon as a result of navigation through the tortuous path of the cardiovascular system or other vessels of the body to the preselected site for deployment, particularly if the stent surface is smooth and/or the stent thickness and diameter are small. The rough surface of the outer layer provides the stent with high retention force, exceeding 2.5 Newton, even where less mechanical grip exists because of thin stent strut thickness, and the stent is mounted on a small diameter (e.g., <1.0 mm, uninflated) balloon.
Other techniques may alternatively be used for forming a relatively rough outer surface on the stent, suitable for purposes of the present invention. For example, the surface may be treated to electropolishing in which an acid is applied or added to the bath, and a predetermined current of several amperes is applied, so as to create a rough rather than a smooth surface. Or, metal particles may be sputtered onto the metal surface of the stent, such as stainless steel 316L particles sputtered onto a 316L stent surface, to increase the surface roughness. Or, the stent may be cut from a rough and porous tubing using techniques which have been implemented by the aforementioned Hittman company. These examples are merely illustrative, not exhaustive.
Although the iridium oxide coating on the stent is an inorganic biomaterial, it exhibits an ability to reduce the degree of inflammation which could otherwise occur when such biomaterial contacts the human body. Normally, an inorganic biomaterial is a passive structure with only passive mechanical properties. But it has been found that iridium oxide produced by the preferred method herein has catalytic properties, capable of promoting a reaction in which hydrogen peroxide (H2O2) is converted into water (H2O) and oxygen (O2). This reaction normally occurs only in the presence of a catalyst, since hydrogen peroxide is normally kinetically stable and will not decompose spontaneously. To become unstable, a certain kinetic energy is required to overcome the activation energy for hydrogen peroxide decomposition.
It is known that one of the very first responses of the human body to the implantation of a foreign body, such as a stent surface, into the blood vessels is the activation of leukocytes, white blood cells which are one of the formed elements of the circulating blood system. This activation causes oxidative stress with a burst of reactive oxygen compounds (100 times higher than the baseline production). One of the key molecules in this process is hydrogen peroxide, released by neutrophilic granulocytes which constitute one of the five types of leukocytes. While O2 is always present and generated in a normal cell cycle, in the mitochondria the reaction of O2 to superoxide anion O2 (i.e., reactive form of oxygen when molecular oxygen gains a single electron) is reduced to H2O2 by the enzyme superoxide dismutase. The enzyme catalase serves as a converter of H2O2. The presence of H2O2 is a very strong trigger for inflammation. And in a situation where inflammation is occurring, when the granulocytes produce 100 times more O2 than normal, the normal catalytic activity of the body is insufficient to convert the increased amount of H2O2 to water and oxygen in its metabolic process. It has been found that this iridium oxide surface of the stent, though a primarily passive structure, is a biologically active surface which is highly effective in preventing inflammatory reactions. The presence of catalytic properties of an otherwise biologically inactive surface of this biomaterial appears to be partly attributable to molecular adherence of the iridium structure as discussed above, and partly attributable to the porous surface structure of the iridium oxide layer, which enables the stent to be implanted without significant inflammation.
It will be observed that the stent delivery system, method of assembly, and stent of the present invention provides sizing to allow the stent delivery system to traverse small-sized vessels of a human body, nominally ranging in diameter from about 1.25 to less than about 2.5 mm. The delivery balloon has an uninflated diameter considerably less than 2.5 mm, and indeed less than 1.0 mm, ideally from about 0.5 to 0.8 mm, integral with the catheter distally thereof i.e., at or near the distal end of the catheter, through which the balloon may be selectively inflated and deflated via an inflation lumen of the catheter. The stent is adapted to be firmly but removably mounted on the uninflated balloon, as by crimping thereon, and typically is premounted in that way for use by the implanting surgeon upon removal of the delivery system from its package. The overall diameter of this assembly and its crossing profile preferably lies in a range from about 0.5 mm to about 0.8 mm. One of the stent and the balloon includes a feature for increasing the retention force between the stent and the balloon while the stent is mounted on the balloon, so that the stent is held securely in place as the stent delivery system is navigated through the vessel.
According to the preferred embodiment, that is the function of the stent's outer rough surface. It is also possible, however, albeit not preferable, within the confines of the invention, to provide a surface feature of the balloon to achieve that end, or to apply a medical grade biodegradable biomaterial adhesive to the portion of the balloon surface on which the stent is to be mounted. But an adhesive may prevent release of the balloon after the stent is deployed.
Although certain methods and embodiments of the invention have been disclosed herein, it will be recognized from a consideration of the foregoing description that variations and modifications may be made without departing from the spirit and scope of the invention. Accordingly, it is intended that the invention shall be limited only by the appended claims and the rules and principles of applicable law.
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|Jul 19, 2011
|Boston Scientific Scimed, Inc.
|Endoprosthesis with coatings
|Jul 30, 2008
|Jul 26, 2011
|Boston Scientific Scimed, Inc.
|Bioerodible endoprosthesis
|Aug 16, 2011
|Boston Scientific Scimed, Inc.
|Aug 23, 2011
|Boston Scientific Scimed, Inc.
|Bioerodible metallic ENDOPROSTHESES
|Jul 11, 2007
|Aug 23, 2011
|Boston Scientific Scimed, Inc.
|Endoprosthesis coating
|Nov 2, 2007
|Oct 4, 2011
|Boston Scientific Scimed, Inc.
|Stent with embedded material
|Apr 12, 2006
|Nov 1, 2011
|Boston Scientific Scimed, Inc.
|Endoprosthesis having a fiber meshwork disposed thereon
|Aug 2, 2007
|Nov 8, 2011
|Boston Scientific Scimed, Inc.
|Endoprosthesis with three-dimensional disintegration control
|Sep 13, 2007
|Nov 8, 2011
|Boston Scientific Scimed, Inc.
|Medical devices and methods of making the same
|Nov 8, 2011
|Boston Scientific Scimed, Inc.
|Sep 14, 2007
|Nov 15, 2011
|Boston Scientific Scimed, Inc.
|Bioerodible endoprostheses and methods of making the same
|May 11, 2010
|Nov 29, 2011
|Boston Scientific Scimed, Inc.
|Drug-releasing stent with ceramic-containing layer
|Nov 29, 2011
|Boston Scientific Scimed, Inc.
|Stents with ceramic drug reservoir layer and methods of making and using the same
|Dec 6, 2011
|Boston Scientific Scimed, Inc.
|Medical device with a porous surface for delivery of a therapeutic agent
|Mar 4, 2009
|Dec 6, 2011
|Boston Scientific Scimed, Inc.
|Dec 20, 2011
|Boston Scientific Scimed, Inc.
|Bioerodible endoprostheses and methods of making the same
|Feb 1, 2006
|Jan 3, 2012
|Boston Scientific Scimed, Inc.
|Bioabsorbable metal medical device and method of manufacture
|Sep 14, 2007
|Mar 6, 2012
|Boston Scientific Scimed, Inc.
|Bioerodible endoprosthesis with biostable inorganic layers
|May 29, 2012
|Boston Scientific Scimed, Inc.
|Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
|Jul 10, 2012
|Boston Scientific Scimed, Inc.
|Endoprosthesis coating
|Jul 30, 2008
|Jul 17, 2012
|Boston Scientific Scimed, Inc.
|Medical device coating by laser cladding
|Jul 31, 2012
|Boston Scientific Scimed, Inc.
|Medical implants including iridium oxide
|Jun 10, 2008
|Aug 7, 2012
|Boston Scientific Scimed, Inc.
|Bioerodible endoprosthesis
|Aug 7, 2012
|Tyco Healthcare Group Lp
|Stent with enhanced friction
|Sep 11, 2012
|Merlin Md Pte Ltd
|Endovascular device
|Sep 18, 2012
|Boston Scientific Scimed, Inc.
|Self-buffering medical implants
|Apr 24, 2009
|Oct 16, 2012
|Boston Scientific Scimed, Inc.
|Nov 6, 2012
|Remon Medical Technologies Ltd.
|Method and device for electrochemical formation of therapeutic species in vivo
|Sep 30, 2004
|Dec 18, 2012
|Merlin Md Pte Ltd.
|Implantable medical devices with enhanced visibility, mechanical properties and biocompatability
|Sep 10, 2007
|Jan 15, 2013
|Boston Scientific Scimed, Inc.
|Medical devices with drug-eluting coating
|Oct 3, 2008
|Feb 26, 2013
|Boston Scientific Scimed, Inc.
|Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
|Apr 30, 2013
|Boston Scientific Scimed, Inc.
|Coated medical devices for abluminal drug delivery
|May 28, 2013
|Boston Scientific Scimed, Inc.
|Endoprosthesis coating
|May 28, 2013
|Covidien Lp
|Liquid and low melting coatings for stents
|Oct 25, 2006
|Aug 6, 2013
|Merlin Md Pte Ltd
|Medical device
|May 25, 2010
|Nov 5, 2013
|Boston Scientific Scimed, Inc.
|Medical devices having nanoporous coatings for controlled therapeutic agent delivery
|Mar 22, 2011
|Mar 11, 2014
|Boston Scientific Scimed, Inc.
|Surface treated bioerodible metal endoprostheses
|Nov 21, 2011
|May 6, 2014
|Boston Scientific Scimed, Inc.
|Bioerodible endoprostheses and methods of making the same
|Apr 9, 2007
|May 6, 2014
|Merlin Md Pte Ltd.
|Endovascular device with membrane
|May 3, 2011
|May 20, 2014
|Palmaz Scientific, Inc.
|Endoluminal implantable surfaces, stents, and grafts and method of making same
|Jun 15, 2007
|Jul 8, 2014
|Boston Scientific Scimed, Inc.
|Medical devices with selective titanium oxide coatings
|Sep 14, 2007
|Aug 19, 2014
|Boston Scientific Scimed. Inc.
|Bioerodible endoprostheses and methods of making the same
|Jul 27, 2007
|Aug 26, 2014
|Boston Scientific Scimed, Inc.
|Drug eluting medical devices having porous layers
|Jun 28, 2006
|Aug 26, 2014
|Boston Scientific Scimed, Inc.
|Coatings for medical devices comprising a therapeutic agent and a metallic material
|Jan 5, 2006
|Sep 23, 2014
|Boston Scientific Scimed, Inc.
|Bioerodible endoprostheses and methods of making the same
|Oct 6, 2009
|Dec 2, 2014
|Boston Scientific Scimed, Inc.
|Coating for medical device having increased surface area
|Mar 15, 2013
|Dec 2, 2014
|Covidien Lp
|Liquid and low melting coatings for stents
|Oct 15, 2004
|Dec 23, 2014
|Merlin Md Pte Ltd.
|Method for treating aneurysms
|Aug 5, 2013
|Dec 30, 2014
|Merlin Md Pte. Ltd.
|Medical device
|Apr 17, 2009
|Dec 30, 2014
|Boston Scientific Scimed, Inc.
|Medical devices having a coating of inorganic material
|Apr 23, 2009
|Jan 13, 2015
|Boston Scientific Scimed, Inc.
|Medical devices having inorganic particle layers
|Jun 28, 2012
|Apr 21, 2015
|Covidien Lp
|Stent with enhanced friction
|Jul 17, 2008
|Mar 15, 2016
|Boston Scientific Scimed, Inc.
|Endoprosthesis having a non-fouling surface
|Nov 12, 2014
|May 10, 2016
|Covidien Lp
|Coated stent comprising an HMG-CoA reductase inhibitor
|Mar 23, 2001
|Sep 26, 2002
|Scimed Life Systems, Inc.
|Medical device having radio-opacification and barrier layers
|Dec 21, 2001
|May 1, 2003
|Chandrashekhar Pathak
|Liquid and low melting coatings for stents
|Feb 4, 2004
|Aug 12, 2004
|Travelocity.Com Lp
|Process to graphically display travel information on a map in electronic form
|Mar 13, 2003
|Sep 16, 2004
|Scimed Life Systems, Inc.
|Medical device
|Apr 2, 2003
|Oct 7, 2004
|Sweet Carl Scott
|Nose bleed treatment device and method
|Jul 22, 2004
|Dec 23, 2004
|Ev3 Peripheral, Inc.
|Stent with enhanced friction
|Jan 20, 2004
|Jul 21, 2005
|Jan Weber
|Functional coatings and designs for medical implants
|Mar 12, 2004
|Sep 29, 2005
|Lixiao Wang
|MRI and X-ray visualization
|Jul 18, 2005
|Nov 10, 2005
|Scimed Life Systems, Inc., A Minnesota Corporation
|Medical device having radio-opacification and barrier layers
|Jul 29, 2004
|Feb 2, 2006
|Jan Weber
|Medical device having a coating layer with structural elements therein and method of making the same
|Sep 22, 2003
|Jul 13, 2006
|Abbott Laboratories Vascular Enterprises Limited
|Stent with rough surface and its manufacture
|May 27, 2003
|Jul 27, 2006
|Ev3 Peripheral, Inc.
|Coated stent
|Sep 30, 2004
|Mar 22, 2007
|Deepak Gandhi
|Implantable medical devices with enhanced visibility, mechanical properties and biocompatability
|Oct 25, 2006
|May 3, 2007
|Leon Rudakov
|Medical device
|Dec 30, 2005
|Jul 5, 2007
|Jan Weber
|Internal medical devices containing peroxide-converting catalysts
|Oct 15, 2004
|Aug 16, 2007
|Leon Rudakov
|Method for treating aneurysms
|Apr 9, 2007
|Nov 1, 2007
|Merlin Md Pte Ltd
|Endovascular device with membrane
|Sep 24, 2007
|Jun 19, 2008
|Torsten Scheuermann
|Endoprosthesis with coatings
|Jul 13, 2007
|Jan 15, 2009
|Jan Weber
|Boron-Enhanced Shape Memory Endoprostheses
|Feb 13, 2006
|Feb 26, 2009
|Merlin Md Pte Ltd.
|Endovascular device with membrane
|Jul 17, 2008
|Jun 11, 2009
|Boston Scientific Scimed, Inc.
|Endoprosthesis having a non-fouling surface
|Sep 28, 2010
|Mar 17, 2011
|Ev3 Peripheral, Inc.
|Liquid and low melting coatings for stents
|Jun 23, 2011
|Claus Harder
|Medical implant, coating method and implantation method
|Jun 28, 2012
|Oct 25, 2012
|Tyco Healthcare Group Lp
|Stent With Enhanced Friction
|May 3, 2011
|Nov 8, 2012
|Palmaz Scientific, Inc.
|Endoluminal implantable surfaces, stents, and grafts and method of making same
|Sep 20, 2002
|Mar 31, 2004
|Abbott Laboratories Vascular Enterprises Limited
|Stent with rough surface and its manufacturing method
|Sep 30, 2004
|Jul 26, 2006
|Merlin MD PTE Ltd
|Implantable medical devices with enhanced visibility, mechanical properties and biocompatibility
|Sep 22, 2003
|Apr 1, 2004
|Abbott Laboratories Vascular Enterprises Limited
|Stent with rough surface and its manufacture
|Aug 30, 2005
|Mar 9, 2006
|Interstitial Therapeutics
|Medical stent provided with inhibitors of atp synthesis
|U.S. Classification
|623/1.1, 623/1.46, 606/192
|International Classification
|Cooperative Classification
|European Classification
|Dec 19, 1999
Owner name: INFLOW DYNAMICS, INC., VIRGINIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ECKHARD ALT;REEL/FRAME:010448/0913
Effective date: 19991213
|Sep 29, 2004
|Fee payment
Year of fee payment: 4
|Oct 31, 2006
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA
Free format text: MERGER;ASSIGNOR:INFLOW DYNAMICS, INC.;REEL/FRAME:018463/0254
Effective date: 20051130
Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA
Free format text: MERGER;ASSIGNOR:INFLOW DYNAMICS, INC.;REEL/FRAME:018463/0254
Effective date: 20051130
|Sep 18, 2008
|Fee payment
Year of fee payment: 8
|Sep 19, 2012
|Fee payment
Year of fee payment: 12


text:
microsoft technician jobs near Albany, NY
Refine your searchClear Filters
Date Added
More Filters
Senior Project Manager
nfrastructure - Clifton Park, NY
PMP certification Experience with Service desk tool suites Experience with low voltage cabling and Security and Alarm systems Experience with the concepts of...
Air Products - Albany, NY
Strong computer skills – Microsoft Office. Experience in military roles as a Machinist Mate, Electricians Mate, Electronic Technician, Aircraft Maintenance or...
Senior Building MEP Estimator
WSP | Parsons Brinckerhoff - Albany, NY
We have approximately 31,500 employees, including engineers, technicians, scientists, architects, planners, surveyors, program and construction management...
BC Broadband Services Tech 1
Time Warner Cable - Latham, NY
Business Class Technicians. Accountable for referring problems between the customer premise and tap to plant technicians....
Tower Technician I
Ericsson - United States
Telecom Tower Technician I. Must have high level of computer proficiency, including a working knowledge of all Microsoft Office suite products....
Information Assurance Tech II
Exeter Government Services - United States
Microsoft Certified Solutions Associate (MCSA) or. Microsoft Certified Information Technology Professional (MCITP) or....
Windows Server Systems Admin/Engineer - 365+ Days
VOLT TECHNICAL RESOURCES - New York State
Microsoft Client Management (Group Policy, Desktop Imaging). Coordinate and communicate with impacted staff and technicians....
Technical Support Representative
Verizon - Albany, NY
ACTC (Apple Certified Technician Coordinator. Knowledge of Microsoft Windows and PC hardware and software. As a Technical Support Representative, you will be...
Systems Support Technician
ITT Educational Services Inc. - Albany, NY
Efficiently utilize a personal computer and related software including Microsoft Office, departmental specific software and Internet proficiencies....
Tier 2 Technical Support Representative
Verizon - Albany, NY
Fiber Network Technician SI. ACTC (Apple Certified Technician Coordinator. Provide support for the Installation and Maintenance Technicians during service...

subset: commoncrawl


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Kids News
Call for greater availability of ADHD therapy
Tim Sandle
The U.S. Centers for Disease Control and Prevention (CDC) has called on more resources to be ploughed into offering therapy sessions for children the ADHD.
Aeropostale files for bankruptcy protection, closes Canada stores
Nathan Salant
New York - After three consecutive years of losses, teen clothing retailer Aeropostale Inc. filed for Chapter 11 bankruptcy on Wednesday and pledged to reorganize.
Kids form human arrow, help police find fleeing burglary suspects
Megan Hamilton
A plucky group of kids who were out with their parents on an Easter egg hunt helped Surrey police get their men, forming a human arrow in a field and pointing out where the man was hiding to a National Police Air Service helicopter.
Making trick-or-treating safer for kids
Tim Sandle
Toronto - October 31 is edging closer and this Saturday many children will be dressing up and knocking on neighborhood doors. To make sure everyone is safe, the Canadian Centre for Child Protection has offered some tips.
Australia will penalize parents who don't vaccinate their kids
Owen Weldon
On Wednesday, the Australian government said it will pass a law that would penalize those who don't immunize their kids by withholding child care and other payments.
Are kids in the U.S. starting the school day too early?
Tim Sandle
Washington - Too many children in the U.S. are starting the school day too early, according to a new report. As a consequence, kids are not getting a sufficient amount of sleep and this is impacting their educational performance.
Brand name baby food, fruit snacks subject to nationwide recall
Nate Smith
A pair of popular Canadian snack foods for children and babies are being recalled over fears of spoilage, according to the Canadian Food Inspection Agency.
Warning over swimming related drowning deaths
Tim Sandle
In the U.S. there has been a spate of avoidable deaths by drowning. This is due to "underwater breath-holding behaviors," which has become a popular dare among young people.
Op-Ed: Crayons found to contain asbestos, sparks health warning
Tim Sandle
A consumer group has triggered an alert after asbestos was found in children's crayons and a toy lab kit. The products were imported into the U.S. from China and not checked by a range of major retail outlets.
Physically active children are happier
Tim Sandle
London - A child focus exercise campaign called Change4Life, backed by Disney's 10 minute shake up campaign, has begun in the U.K. To accompany this, a report has been issued explaining the benefits of physical exercise for children.
New call for healthy eating in schools
Tim Sandle
Politicians in Europe are calling for a new scheme to be introduced to promote healthy eating in schools throughout the European Union.
Sadistic dentist accused operating 'house of horrors'
Nate Smith
A Florida dentist accused of torturing his young patients has agreed to cease practicing dentistry amidst a series of lawsuits from former clients.
Google unveils YouTube for Kids, available now on Android and iOS
James Walker
Google has unveiled its long-anticipated YouTube for Kids app that promises to give parents control over what video content their children consume and the ability to limit viewing hours while creating an attractive interface for kids.
Parents investigated after their kids, 10 and 6, walk home alone
Owen Weldon
A mother and father from Maryland are being investigated for neglect after they let their 10 and 6-year-old walk home alone.
Making batteries safer if kids swallow them
Tim Sandle
In every town at some point a child is admitted to hospital for swallowing a battery. The outcome can be serious: burns, damage to the digestive system, a torn esophagus. Researchers have investigated how to make batteries safer.
Best choice for summertime hydration
Christopher Wager
Kids need proper hydration not only to preform and feel their best, but to stay healthy and out of danger. High heat indexes and summer sports can leave kids out of time and out of fluid. Learn what exports are saying about energy drinks and hydration.
Amazon sued by U.S. regulators over kids apps
Tim Sandle
Washington - The US Federal Trade Commission (FTC) has sued Amazon. The FTC says that Amazon allowed millions of dollars of unauthorized purchases by children to take place in its mobile app store.
South Korean girls build backpacks out of junkfood containers
Walter McDaniel
Some students are making snack back packs from discarded junk food containers. Everything from bottles of yogurt to "Pocky" containers is getting transformed by South Korean girls.
Iowa passes bill to legalize cannabis treatment for children
Nora Meszaros
Des Moines - Families across Iowa celebrated the news Friday that Governor Terry Branstad signed the bill enabling a low-THC medical marijuana oil extract to be used as treatment for children with severe epilepsy.
Florida passes medical marijuana bill for epileptic children
Nora Meszaros
Tallahassee - A strain of low-potency marijuana became legalized in Florida yesterday to help treat epilepsy and cancer patients, including children.
Missing 3-year-old boy found in an arcade claw machine with toys
Jeannie Stokowski-Bisanti
A three-year-old boy crawled up into a claw machine and enjoyed playing with the toys inside while his mother searched for him.
Op-Ed: One more girl: 13-year-old American injured by the HPV vaccine
Jeannie Stokowski-Bisanti
Thirteen-year-old Skylee Butler's life has not been the same since receiving the Human papillomavirus or HPV vaccine in Massachusetts last August.
Op-Ed: Should you feed your kids organic food?
Tim Sandle
Should concerned parents feed their kids organic food or does it make little difference? Or does it even cause harm? According to a new report the jury is still out. See what you think and comment below.
What's the best way to read to a baby?
Tim Sandle
Researcher and writer Elaine Reese has provide some tips for reading to new babies. Although babies do not seem to react much, Reese argues that reading out loud has benefits for the baby's development.
Chuck E. Cheese: Will a buyout save the mouse's house?
Karen Graham
Twenty-somethings know what Chuck E. Cheese is all about, and for a number of years, it was a family institution. What kid doesn't like going to a place where they can eat pizza and play fun games? But times have changed, and parents have changed, too.
New video game tries to combat cyberbullying
Al Boe
A new simulation video game from Pixelberry Studios is teaming up with The Cybersmile Foundation to battle many issues a typical high school student goes through, including bullying.
Op-Ed: Banning fun — Tyranny on the rise in schools
Cameron Christner
A Long Island middle school has taken away virtually all playground equipment, banning "anything that might hurt someone."
Op-Ed: Going pro in the 21st century: Why my son won't become athlete
Daniel Taibleson
Children's participation in sports is a part of the fabric of American culture, and the number of children playing sports today is greater than ever.
Scrooge to hand out 'fat' letter to obese kids on Halloween
Karen Graham
Fargo - Halloween has for years been the realm of children, trick-or-treating for candy with their friends. But if a Fargo, N.D. woman has her way, any children she thinks may be overweight are going to get "scrooged" on Halloween.
North American moms want M&M's to change their recipe
Jeannie Stokowski-Bisanti
M&M's candies contain petroleum-based, artificial dyes that can trigger hyperactivity in sensitive children. M&M's are made without most of those dyes in Europe and one mother wants to know why they are still being used in North America.
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Kids Image
People protesting in the streets of Tel Aviv against the decision to deport 400 children of foreign workers. Photo: Alessandro Di Maio
Alessandro Di Maio
People protesting in the streets of Tel Aviv against the decision to deport 400 children of foreign workers. Photo: Alessandro Di Maio
Alessandro Di Maio
Spending more time outdoors playing or gazing into the distance might be good for kids' eyes, a University of Cambridge study suggested.
Mike Baird / Flickr
Contestants in the Peach Eating Contest at the 70th annual Johnson County Peach Festival. Clarksville, Ark. June 17, 2011
Kay Mathews
Children at an orphanage in Man, Côte d'Ivoire.
United Nations photo
A family enjoying some sledding fun Colchester, UK
TKO PTSD Project.
Shawn J. Gourley
Muhammad Arif Shafi
The park comes alive
Jim Zamichieli
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President Barack Obama greets children upon arrival in Seattle, Wash.
White House photo by Pete Souza
CHILDREN: Kids get quiet for story time in a kindergarten classroom in Marina, Calif., in 2007.
daveparker / Wikimedia
The PS22 Chorus performing at the 2011 Academy Awards. "I made this film because I was mesmerized by the chorus," notes Kalafer, "Mr. B's teaching style, the kids personalities, and of course all that amazing music. It was such a splendid subject to work with."
Arvind Gupta teaching Indian children about science
Courtesy Arvind Gupta
MUZIK Celebrity Classic Children's Festival
KJ Mullins
Chinese children
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Kids holding hands on a ride. Tontitown Grape Festival. Tontitown, Ark. Aug. 9, 2011.
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The splash park was another popular destination for kids. Bentonville, Ark. June 10, 2011
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Are any of these little faces listed on the TSA No Fly List for Tiny Terrorists?
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Check out these Affairs to Remember Auction Items!
Published on Jun 23, 2016
Imagine yourself cruising through Europe on a Viking River Cruise. We have a Viking trip up for bid at our auction. One of these four experiences could be yours: Paris & the Heart of Normandy, Romantic Danube, Rhine Getaway or Danube Waltz. Get your tickets here now!


text:
Arrested for Public Intoxication, Christina Aguilera Dissed by Pink
Christina Aguilera has recently run into trouble with law. The "Dirrty" singer, along with her boyfriend Matt Rutler, was pulled over by cops on early Tuesday morning, March 1. She was reportedly extremely drunk and a nuisance, while Matt was allegedly driving under the influence.
She was arrested for allegedly violating California Penal Code 647(f) for public intoxication, and Matt was booked for suspicion of DUI. "When she got out of the car, she couldn't stand. We had to help her stand," L.A. County Sheriff's spokesperson Steve Whitmore said to Us magazine. "She didn't know where she was and she didn't know her own address. We took her into custody for her own protection."
Soon after the news spread on the web, Pink who is not very much of X-Tina's fan took it to her Twitter to diss her "Lady Marmalade" collaborator. She wrote, "Out of Myself, Britney, and Christina- didn't everyone think I was gonna be the troublemaker? LOOK MA!!! No CUFFS!!!"
When she was pulled over by police, Christina reportedly was on her way home after having a night out with Matt at Mario Batali's restaurant Osteria Mozza. TMZ reported they hung out in the private dining room past midnight, and drank "a bottle of wine... or two."
A mugshot of Christina has been revealed, and it's certainly not one of her better looks. Steve said that the picture was not meant to be released to public because authorities do not plan to press charges, but sometimes leak just happens especially when it comes to someone as famous as her.
Attorney Allison Margolin of Los Angeles' Margolin Law Office explained to The Hollywood Reporter of X-Tina's case, "I've never in my career heard of someone prosecuted while just being a passenger." Talking about the "public intoxication" allegation, Allison stated, "It's debatable if being a passenger in a car would qualify as being in a 'public space'."
Christina reportedly was released at 7:30 A.M., and was picked up by a man believed to be her bodyguard. Rutler, meanwhile, left police custody a few hours later at 9:30 A.M. with bail set at $30,000. Both of them were said to be "cooperative" with the officers.
More Christina Aguilera News
- 'Rogue One' Releases More New Photos. Also Get Detail of Mon Mothma's Bigger Role
- Taylor Swift Flies to U.K. to Meet Tom Hiddleston's Mom. See Picture of Their Happy Outing
- 'Game of Thrones' Season Finale Won't Slow Down the Pace, People Will Die
- Audrina Patridge and Fiance Welcome Baby Girl Kirra Max
- Getting Married? Tyga Calls Kylie Jenner His 'Wifey'
- Christina Aguilera Performs 'Change' on 'Jimmy Kimmel Live!' to Support Orlando
- Justin Bieber's Music Video Vixen Xenia Deli, 26, Marries 62-Year-Old Man in Lavish Wedding
- Mariah Carey Reportedly Wants to Withhold Sex Before Her Wedding


text:
Add Some Awesome To Your Nuptials With Essie's Colorful Bridal Polishes
If you're the kind of girl who would walk down the aisle rocking neon tips and nail art, then we say congrats to your soon-to-be hubby — he's about to lock down one awesome lady. But not everyone is comfortable with color, which is why the majority of wedding polishes tend to be barely-there pinks and creams. Boring.
There's no reason you can't wear color on your digits for your big day — it can look really gorgeous without being garish, despite what your new mother-in-law might say. But if you're hesitant to go for full-blown rainbow hues on your tips, there's still a way to punch up your polish without stepping too far outside your comfort zone.
Essie's '12 Bridal Collection features four creamy, candy-hued polishes to accent your soon-to-have-a-ring-on-it fingers. There's reflective pink Like To Be Bad, mint green Who Is The Boss, glittery white Instant Hot, and lilac Love & Acceptance. The colors are described as a collection that "celebrates brides who are confident and want to have fun with color, yet with a nod to tradition." Sounds about right to us! How about you? Would you strut down the aisle in one of these shades?
Essie 2012 Bridal Collection, $8 each, Essie for salons.
- Beauty |
- Nails |
- Nail Polish |
- Essie | Essie Wedding Collection - Bridal Nail Polish Shades
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Nail artist Jin Soon Choi is always looking to the future. To wit: She and her nail lacquers are regularly spotted backstage at Fashion Week setting the trends for the next season — and her nail art is always ahead of the curve. Which is why we're happy to see the nail guru take a cue from the past for her first summer ...
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text:
South Lake Tahoe Mercedes Benz
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From Business: Mercedes-Benz of Reno, a Reno Mercedes-Benz dealer, has a vast inventory of new & used Mercedes cars, trucks and SUVs.
2. Mercedes Benz Service by Automotion Compact Car
I had engine problems and was from out of state and these guys treated me as if I were a life long customer. They saved my vacation by providing exc…
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I have had the most pleasant experience here. The staff is so accommodating and even though the repairs are pricey they still make you feel comforta…
4. German Motors
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From Business: Audi Service and Repair
5. Legend Auto Sales - CLOSED
A wonderful treat and a very personable stylist. A special thanks to Gabriel. I will definitely be coming back.
6. TeamTrailersPlus.com
This place is awesome! I went to every trailer dealer in Reno and Carson, no one had dump trailers in stock. TEAM Trailers Plus has more trailers in…
7. Nick's Custom Golf Cars
Nick did such a good job servicing my old cart that I naturally chose him for my new cart six years ago. Their home maintance service program is co…
8. Cordova Truck Dismantlers
These guys are awesome, got me outta a tight place. Bobs awesome give that man a raise!
9. United Truck Dismantlers
2488 McGowan PkwyMarysville, CA 95901
10. Champion ChevroletServices
Kevin was great & helpful. Made it easy to transition to new vehicle .
11. Airdraulics Inc.
13261 Saticoy StNorth Hollywood, CA 91605
From Business: Airdraulics provides a wide variety of equipment for auto shops throughout the greater Los Angeles area. Customer satisfaction is our ultimate goal; our staff is co…
12. Carson City Toyota Scion
2590 S. Carson StCarson City, NV 89701
From Business: Dick Campagni's Carson City Toyota in Carson City, Nevada, a family owned and operated dealership since 1985, has been voted the best place to buy a car by Reader's…
13. LemonBuyBack.com-Law Offices of Jon Jacobs
I can honestly say that my experience with Jon Jacobs has surpassed my expectations. In fact, his whole staff, from Kathy (office manager) to all th…
14. Capital Ford and Carson City Hyundai
Gary has been extremely professional and helpful. Good experience here!
15. Sierra Mountain Sports
2719 Lake Tahoe BlvdSouth Lake Tahoe, CA 96150
16. Yellow Cab
South Lake Tahoe, 96150South Lake Tahoe, CA 96150
17. CardinaleWay Toyota
being a retired kiwi on extended vacation i bought a used toyota out of the dealership from the very moment i walked on to the yard i was treated f…
18. Auto Locators
3542 US Highway 50South Lake Tahoe, CA 96150
19. Tveten Auto Sales - CLOSED
HWY 50 & Hwy 89South Lake Tahoe, CA 96150
20. Rodney's Import Auto
1748 D St Ste 6South Lake Tahoe, CA 96150
21. Affordable Auto & Truck Sales
2296 Lake Tahoe BlvdSouth Lake Tahoe, CA 96150
22. ASB Auto Wholesale
11025 Pioneer Trl # 104Truckee, CA 96161
23. Truckee Automall
10975 Pioneer TrlTruckee, CA 96161
24. Truckee Tahoe Auto Sales
40161 Truckee Airport RdTruckee, CA 96161
25. Tom Hunter Photography
10100 Pioneer Trail Rd. #39Truckee, 96161
26. Jones West Ford
I bought a car at Jones West Ford a couple months ago (from Josh, who was great) & it was by far the best auto buying experience I've ever had. I f…
27. Wells Auto Sales Inc.
179 Placerville DrPlacerville, CA 95667
28. Dalool Performance
1200 S Rock BlvdSparks, NV 89431
29. Liberty MotorsProducts
From Business: Liberty Dodge Chrsyler is an automobile dealership that offers new and pre-owned cars, crossovers, vans, trucks and sport utility vehicles. Its range of Chrysler mo…
30. Budget Auto Sales - CLOSED
My husband and I dealt with Vincent,he and his staff went out of their way to make our car puchase pleasant and enjoyable.I would recommend this bus…


text:
The Drops Of Clarity Desktop
Reader ravenclawwit is no stranger to our featured desktop series, and submitted this beautiful setup to our Desktop Showcase a few weeks ago. It looks great, from top to bottom, and is pretty heavily personalised. It also has a little secret.
The Alfred Emoji Pack Makes Searching For Emoji On A Mac Less Painful
Mac: The newest version of Alfred introduced improved text expansion. The cool thing is you can easily download packs from other people to implement them in Alfred. Joel Califa created a series of auto expansion rules and searches that makes finding and adding emoji a ton easier.
The Departure Songs Desktop
We've seen some simple desktops and some busy ones, but this one from reader Peregerine, walks the line pretty well. It keeps a lot of the space in the center clear so you have plenty of room to work, but also adds some widgets and tools around the periphery that are useful and informative.
Hemingboard For Mac Instantly Suggests Synonyms, Puns And Rhymes
Mac: Hemingboard began as an iOS keyboard that works like an amped-up thesaurus, not only suggesting synonyms to whatever you're typing, but also rhymes and similar-sounding words that you can use as puns. Now they have brought their wordplay weaponry to your desktop.
Everything Apple Announced At WWDC That Actually Matters
Why I Bought A Chromebook Instead Of A Mac
The Edge Of The World Desktop
Qwiki For Mac Lets You Search And Read Wikipedia Directly From Your Menu Bar
Lacona Is A Launcher For OS X That Uses Natural Language Input
Mac: You have a ton of great launchers on Mac and even the built-in Spotlight does a good enough job for most of us. If you're looking for something a little different, Lacona is an app currently in beta that takes a natural language input approach.


text:
Comedy & Stand-up in Minneapolis
Stand Up and Live Comedy in Minneapolis
Bob Saget dates for your diary
Dates from August 7th
Do we really need to introduce Bob Saget? Something of a cult television icon now, Bob Saget starred on two of America's most family-friendly shows TV has ever seen, namely "Full House" and "America's Funniest Home Videos". But you may not... Read more Buy Tickets
Louis C.K.
Dates from August 2nd
A 20+ year veteran of the stand-up comedy scene, Louis C.K. is also an accomplished filmmaker and award-winning writer. Influenced by comics... Read more Buy Tickets


text:
GOP Leaders Need to Put Country Before Party
Nobel Scientists Ask Greenpeace to Abandon Campaign Against Genetically Modified Crops
Debt Deflation -- the Economic Concept That Proves Market Optimists Wrong
With Half a Million Ballots Left to Count, Likelihood of Sanders Win in California Dims
We Live in an Age of Disintegration
By David Sirota $11.16
Richard Ellis $17.41
The spat between the actor and former State Department staffer Alec Ross frames an issue that hasn't gotten the attention it deserves in the presidential race.
This is the narrative result of an encounter between Cusack, Roy and whistleblowers Edward Snowden and Daniel Ellsberg. Cusack and Roy provide their own accounts and joint conversations.
Actor John Cusack has said Barack Obama is "as bad or worse" than former President Bush when it comes to civil liberties, drone strikes, freedom of the press and the National Security Agency.
Actor John Cusack is ramping up his political presence during this election cycle with his film "War, Inc." and now this advertisement from MoveOn.org, in which he points out how George W. Bush and John McCain are remarkably similar in some pretty fundamental ways, regardless of McCain's recent bids to distance himself from the outgoing president.
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Posted on Jul 1, 2016
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text:
Wingate By Wyndham Frisco Texas
Wingate By Wyndham Frisco Texas
Hotel Guest Rating: 8.4/10
14700 State Highway 121
Frisco, TX 75035
Hotel Freebies Available*
• On Sale Now -> Save 15% on select dates show dates
• On Sale Now -> Save 15% on select dates show dates
• Free Breakfast show dates
• Free Internet in Room show dates
• Free Parking show dates
Welcome to the Wingate By Wyndham Frisco Texas
A free hot breakfast, heated indoor pool and free Wi-Fi make the non-smoking Wingate by Wyndham Frisco Texas a hit among Priceline guests.
Hotel Features
This four-story hotel has 100 non-smoking rooms with free Wi-Fi, flat-panel cable TVs, refrigerators, microwaves and coffeemakers. A free hot breakfast is served daily. Keep up your fitness regimen with a visit to the fitness center or a swim in the heated indoor pool. Parking is free.
Hotel Location
On Highway 121, the hotel is a 36-minute drive from the dining and entertainment of downtown Dallas. Play a round of golf at The Golf Club at Frisco Lakes or tour Southfork Ranch, the filming location for the "Dallas" TV series, both 14 miles away. The JFK Memorial is 28 miles away. It's 26 miles to Dallas Love Field Airport and 27 miles to Dallas/Fort Worth International Airport.
Guest Favorites
Priceline guests appreciate the "large rooms, great decor with fun photos and tasty breakfast" at Wingate by Wyndham Frisco Texas.
Wingate By Wyndham Frisco Texas Amenities
- 24-hour front desk
- Accessible facilities
- Accessible parking
- Adjoining rooms
- Air conditioning
- Alarm clock
- ATM/Cash machine
- Baggage hold
- Brailed elevators
- Business center
- Closets in room
- Coffee/Tea maker
- Coin operated laundry
- Complimentary buffet breakfast
- Complimentary continental breakfast
- Complimentary in-room coffee or tea
- Conference facilities
- Cribs
- Desk with lamp
- Elevators
- Exercise gym
- Express check-out
- Family/oversized room
- Free high speed internet connection
- Free local calls
- Free newspaper
- Free parking
- High speed internet access
- High speed internet access for laptop in public areas
- High speed internet connection
- Ice machine
- Indoor pool
- Interior corridors
- Internet services
- Ironing board
- Meeting rooms
- Microwave
- Motorcycle parking
- Non-smoking rooms (generic)
- Onsite laundry
- Outdoor parking
- Parking
- Photocopy center
- Ramp access
- Remote control television
- Rollaway bed
- Safe
- Security
- Vending machines
- Wakeup service
- Wheel chair access
- Wireless connectivity
- Wireless internet connection
- Wireless internet connection in public areas
Hotel Information
You must show a valid photo ID and credit card upon check-in. Please note that all special requests cannot be guaranteed and are subject to availability upon check-in. Additional charges may apply. Guests are required to show a photo identification and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.
Hotel Guest Reviews of the Wingate By Wyndham Frisco TexasOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
Sort by: All Travelers | Business Traveler(19) | Solo Traveler(11) | Traveling as Couple(28) | Family with Young Children(11) | Family with Teens(2) | Senior Traveler(1) | Group Traveler(1)
Verified Hotel Guest from Plano, TX
June 12, 2016
Business Traveler
June 12, 2016
Business Traveler
Location, new and clean hotel.
too much breach in the pool.
Jennifer from Aledo, TX
May 31, 2016
May 31, 2016
The room was OK breakfast ok
Staff are morons no manager was ever on site. When I called still no manager he only does email. Bad hospitality.
Verified Hotel Guest from Waterloo, IA
May 30, 2016
May 30, 2016
Good location!
Lack assortment of food at free breakfast.
Alfred from Abilene, TX
May 28, 2016
May 28, 2016
The mattresses was very comfortable!
Bruce from Mckinney, TX
May 23, 2016
May 23, 2016
Expensive for a medium hotel
Verified Hotel Guest from Tulsa, OK
May 21, 2016
Family Traveling with Young Children
May 21, 2016
Family Traveling with Young Children
Everything met or exceeded my expectations.
Michael from Oklahoma City, OK
May 9, 2016
Business Traveler
May 9, 2016
Business Traveler
the bed was very uncomfortable
Verified Hotel Guest from Pottsboro, TX
May 6, 2016
May 6, 2016
Our room was right off the elevator veryconvenient. Great location just minutes from everything.
Amanda from Concord, NC
May 1, 2016
Family Traveling with Young Children
May 1, 2016
Family Traveling with Young Children
This guest did not leave comments about this hotel.
Verified Hotel Guest from Decatur, IL
April 29, 2016
Solo Traveler
April 29, 2016
Solo Traveler
I've stayed here before and they are top notch. Clean and friendly.
It's on the edge of town. Most activities are a located more towards the center.
Reviews of Wingate By Wyndham Frisco Texas
(1 - 10 of 80 reviews)
(1 - 10 of 80 reviews)
from $84
- Comfort Inn & Suites Frisco - Plano from $94 (3.3mi)
- Aloft Frisco from $103 (4.1mi)
- Hampton Inn & Suites Legacy Park-Frisco from $79 (4.1mi)
- Holiday Inn Express Frisco from $84 (4.1mi)
- Homewood Suites By Hilton Dallas-Frisco from $109 (4.1mi)
- Fadi's Mediterranean (3.5mi)
- Romano's Macaroni Grill (3.5mi)
- California Pizza Kitchen (3.6mi)
- Cheesecake Factory (3.6mi)
- Jinbeh (3.6mi)
- Fazio (5.6mi)
Most Popular Guest-Rated Hotels in Frisco
- Homewood Suites By Hilton Dallas-Frisco
- Embassy Suites Dallas -Frisco/Hotel, Convention Center & Spa
- Wingate By Wyndham Frisco Texas


text:
Men Designer Clothing
127 Suppliers
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Gaurav International (Uniform Bazaar/Master Chef)Verified Supplier with TrustSEAL
Manufacturer of designer casual shirts, cheap custom design shirts- ds-36, men designer dress shirts- ds-28, cheap designer s more........Mumbai
Building No. 33, Gala No. 159, Laxmi Industrial Estate Link Road, Andheri West,
Mumbai - 400053, Maharashtra
- Kinny Garments Private Limited
Kinny Garments Private LimitedVerified Supplier with TrustSEAL
We are a leading manufacturer of men designer clothing, boys stone work sherwani, brocade designer sherwani, coat style sherw more........New Delhi
No. 70A- 1, Rama Road, Near Kirti Nagar, Metro Station,
New Delhi - 110015, Delhihttp://www.kinnygarments.in/Get Best Quotes 8447575183New Delhi
Sudarshaan ImpexVerified Supplier with TrustSEAL
We are manufacturer of mens clothing, men embroidered garments, mens casual wear, mens round neck T shirt & mens polo T shirt more........Tiruppur
No. 24/15A, Bridgeway Colony Extension, 4th Street,
Tiruppur - 641607, Tamil Naduhttp://www.sudarshaanimpex.com/Get Best Quotes 8376806485Tiruppur
Gujarat TradersVerified Supplier with TrustSEAL
We are a leading manufacturer & wholesaler of mens clothing. These are widely appreciated for its optimum look, light weight more........Ahmedabad
Gheekanta Market, Gheekanta,
Ahmedabad - 380001, Gujarathttp://www.indiamart.com/gujarattraders/clothing.htmlGet Best Quotes 8048023021Ahmedabad
Daisy (Estd 1989) Apparel DesignersVerified Supplier with TrustSEAL
We offer men designer clothing, men designer clothing, mens sleep wear, mens sport wear & womens sleepwear. We are a leading more........Tiruppur
Daisy House, 209/ 3, R.V.E. Nagar, 6th Street, Nallur,
Tiruppur - 641606, Tamil Naduhttp://www.daisyapparel.com/mens-clothing.htmlGet Best Quotes 8079465672Tiruppur
- Khandelwal Gartex Private Limited
Khandelwal Gartex Private LimitedVerified Supplier with TrustSEAL
Leading exporter & trader of men designer clothing. These are highly appreciated for its beautiful pattern, shrink resistance more........New Delhi
No. 1466, Shambhu Nath Building, Near Bhature Wali Gali Gandhi Nagar,
New Delhi - 110031, Delhihttp://www.indiamart.com/zoora-garments/Get Best Quotes 8048077250New Delhi
- Vogue Sourcing
Vogue SourcingVerified Supplier with TrustSEAL
Leading manufacturer & exporter of men designer clothing. These are widely appreciated for its tear resistance, alluring look more........Tiruppur
2/31, Nethaji Street East Kumaranthapuram,
Tiruppur - 641602, Tamil Naduhttp://www.indiamart.com/voguesourcing/Get Best Quotes 9582243725Tiruppur
- Shyam Sunder Export House, Jute, Textile & Allied Division
Shyam Sunder Export House, Jute, Textile & Allied DivisionVerified Supplier with TrustSEAL
We are exporter & supplier of men designer clothing. These are highly appreciated for its beautiful pattern, shrink resistanc more........Kolkata
Old Jessore Road, Near A. S. G. Biochem Private Limited Ganganagar,
Kolkata - 700132, West Bengalhttp://www.indiamart.com/shyam-sunder/Get Best Quotes 8046051750Kolkata
Gaurav Chhabra & Co.Verified Supplier with TrustSEAL
Manufacturer of indian mens sherwani, mens suits styles, groom suits, men designer clothing, wedding sherwani & ethnic sherwa more........New Delhi
F-52, Okhla Industrial Area, Phase-1,
New Delhi - 110020, Delhihttp://www.gauravchhabra.com/mens-sherwani.htmlGet Best Quotes 9953357141New Delhi
S.p. InternationalVerified Supplier with TrustSEAL
Leading exporter & wholesaler of mens clothing, mens fashion clothing. We also offer men's round neck t shirts & men's shorts more........Tiruppur
8/1, P.N. Road, Anna Nagar West,
Tiruppur - 641652, Tamil Naduhttp://www.spintl.in/mens-half-sleeves-t-shirts.htmlGet Best Quotes 8046042580Tiruppur
Punit Polyfab Pvt. Ltd.Verified Supplier with TrustSEAL
Manufacturer & exporter of men designer clothing. Also offering branded garments, branded jeans, branded tshirt, casual wear more........Ahmedabad
86, 1st Floor, New Cloth Market Raipur,
Ahmedabad - 380002, Gujarathttp://www.punitpolyfab.co.in/party-wear.htmlGet Best Quotes 8377805336Ahmedabad
- Guru Textiles
Guru TextilesVerified Supplier
Manufacturer & exporter of men designer clothing. These are highly admired for its perfect finish, smooth texture & elegant d more........Gurgaon
No. 35 UP, Sector - 40, Huda,
Gurgaon - 122003, Haryanahttp://www.indiamart.com/gurutextiles/Get Best Quotes 9953352213Gurgaon
Cotton ClimateVerified Supplier
Manufacturer & exporter of a wide range of mens clothing. Also deals in men designer clothing from India. more........Ahmedabad
D-296, 3rd Floor, Sumel Biz Park-2, Safal-2, Behind Vanijya Bhavan, Opposite Diwan Ballubhai School Kankaria Road,
Ahmedabad - 380008, Gujarat
- Swift Buying Services
Swift Buying ServicesVerified Supplier
Manufacturer & exporter of mens clothing. These are highly admired for its flawless stitch, excellent designs & smooth textur more........Tiruppur
No. 2, Mariamman Kovil Street Samundipuram, Gandhi Nagar Post Office,
Tiruppur - 641603, Tamil Naduhttp://www.indiamart.com/swiftbuyingservices/Get Best Quotes 8046036445Tiruppur
Apuesto ApparelsVerified Supplier
Manufacturer & trader of men designer clothing. Also offering casual pants, casual shirts, casual shirts n, denim pants & den more........Jaipur
G-1-732, Sitapura Industrial Area, Near Chatrala Circle,
Jaipur - 302022, Rajasthan
- SIR Tailor
SIR TailorVerified Supplier
We are a leading manufacturer & supplier of sangeet mens kurta, sangeet mens kurta. Also deals in men designer clothing from more........Surat
Chauta Pull, Near Sai Belt, Behind Bus Stop Lalgate Main Road,
Surat - 395003, Gujarat
Esvee KnittingsVerified Supplier
A company of up to 100 employees, we are a leading manufacturer & exporter of men designer clothing, men designer clothing, k more........Tiruppur
No. 1, Kongu Nagar Extension, 4th Street, P. O Box No. - 516,
Tiruppur - 641607, Tamil Nadu
- Veshath Apparel Resources
Veshath Apparel ResourcesVerified Supplier
Sourcing men designer apparels like jump suits, t- shirts, hooded t-shirts, golf t-shirts, sweat shirts, boxers shorts, polo more........Tiruppur
No. 41, Sidhappa Avenue, Rayapuram Main Road,
Tiruppur - 641601, Tamil Naduhttp://www.indiamart.com/veshathapparel/Get Best Quotes 8045136565Tiruppur
- Hi Tech Fashion
Hi Tech FashionVerified Supplier
Deals in producing and supplying of men's garments, designer men's t shirts, men's hooded jackets, printed t shirts, simple t more........Tiruppur
No. 8, Apachi Nagar, Second Street, Kongu Main Road,
Tiruppur - 641607, Tamil Naduhttp://www.indiamart.com/hitechfashion/Get Best Quotes 8045136058Tiruppur
Style Fab Innovation Private LimitedVerified Supplier
Our product range includes jodhpuri suit. We are leading manufacturer of men designer clothing from India. more........Ghaziabad
No. 240/228, Gandhi Nagar Near Hari Mandir,
Ghaziabad - 201001, Uttar Pradeshhttp://www.indiamart.com/style-fab-innovation/suits.htmlGet Best Quotes 8046084823Ghaziabad


text:
...I am certified to teach speaking, listening, reading, and writing classes. I have the expertise, tools, and resources to help your student achieve a strong score on the ASVAB. I have more than five years of experience in teaching test-taking and study strategies and a strong track record of improving student's scores.
San Diego, CAView Tutor
...I would also help transfer students determine how their classes from other colleges and universities transferred to UCI. I also updated course descriptions and coordinated with other Schools to help students fulfill course requirements in our school. Beyond my position as a Peer Academic Adviser I have also successfully navigated both college and graduate school.
La Mesa, CAView Tutor
...I have more than 20 years' experience of programming in MATLAB/SIMULINK and associated Toolboxes. I use it every day in my work and when teaching different classes. I will be glad to share my experience with this exceptionally powerful and intuitive programming language with you.
San Diego, CAView Tutor
...I worked for the Admissions office at the University of Nebraska-Lincoln for 4 years. During that time I worked primarily with the department of New Student Enrollment and the Division of General Studies. I have worked with all types of students, from those that know exactly what they want to do, to students who haven't quite figured it out.
San Diego, CAView Tutor
...As a Certificated teacher, I have worked with ADD/ADHD students in both the integrated and Special Ed classroom settings. I have worked with parents, counselors and other teachers to devise ways to help individual students succeed in the classroom and boost performance and self esteem. I am and...
Oceanside, CAView Tutor


text:
Off the Beaten Track -- and Worth it,
This review is from: Fats Navarro Story (Audio CD)
Fats Navarro had a sweet, flawless technique which few trumpeters of his generation possessed. It is, on the one hand, unfortunate that
Navarro's discography is s0 small. On the other hand, except for the recent Savoy reissue of Navarro's best -- which is generous and remastered with great skill -- Proper's FATS NAVARRO STORY is probably the best summation of Navarro's achievement on record. The final sessions with Charlie Parker alone are worth the investment, but for those who shun Parker's brand of bebop, there are ample cuts to soothe and inspire, from a lavish rendition of "Gone with the Wind" to "A Night in Tunisia." The value of the set is simply extraordinary, with four discs, 87 cuts -- most beautifully remastered to capture the warmth of Navarro's tone-color, and an illustrated booklet which provides a brief, but educated, history of an American legend who worked for just a few years, but prepared a new generation of trumpeters for the promise of modernism. All this and a sturdy slipcase, too and you can't go wrong at this price. As someone who respects Miles Davis (especially for his Plugged Nickel set on CBS), I fear too much attention has been paid to Miles and too little to Navarro and Clifford Brown. As usual, Proper Records has developed a package that delights as it educates. And there's absolutely nothing like it in the catalog. Warmly recommended.
Review Details
(9 customer reviews)
4 star
3 star
2 star
Location: Minnetonka, MN USA
Top Reviewer Ranking: 13,801


text:
Youth Hip-Hop fest takes place in Durban on Saturday.
Shark nets at some beaches on the KwaZulu-Natal coast are being lifted ahead of big seas and strong winds expected.
Documentary film-makers Shanelle Jewnarain and Tiny Mungwe have been selected to pitch their documentary inspired by Glenwood sex workers.
One of the five people charged for their alleged part in a multimillion-rand housing tender scam, has pleaded guilty to fraud and money laundering.
Minutes after the eThekwini Municipality's Land Invasion Unit left the Kennedy Road informal settlement.
Focus on acting municipal manager.
One of the men accused of stealing diesel, which led to a fuel tanker exploding at the uMvoti Toll Plaza, could not make ...
Cistes a 'conflict of interest'.
Bullying has cost one schoolboy his life while another is expected in court for murder.
One ANC activist was killed and another critically wounded in Pietermaritzburg.
More than 100 delighted pupils from Greyville Primary School enjoy a Fun Day.
Burn the Floor, the show that revolutionised the image of dance, returns to South Africa.
Wentworth Secondary School embarks on a Winter Warmth initiative.
Wentworth man accused of killing a fellow resident following an argument at a party on the Bluff.
Four paramedics were attacked on Wednesday in Durban and Johannesburg.


text:
I have been using Git for last two years and it's merge has been one of the greatest merges that I have used so far but lately it is just behaving badly. Nothing has changed on my git but every time I do a merge it is just acting up.
For example: I started seeing things like
also ->>>>>>> Stashed changes
<<<<<<< Updated upstream
That is what I see inside my code after it finished auto-merge. Strangely enough, it has not asked me to manually resolve the conflicts in a while as it used to before. It never did that before. Any one has seen this behavior before?


text:
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...Since 2001, and with much success, I have been tutoring k-6 students in the areas of reading, spelling, phonics, vocabulary, math, science, handwriting, common core, and mostly, test prep--all areas--for the FSA, formerly known as the FCAT. My tutoring occurred both at elementary schools where I...
16 Subjects: including ESL/ESOL, English, writing, reading
Miami, FL
...To study with a friend is also effective as one can orally state your thoughts and this ensures that you have mastered that idea. As a teacher I would state the main ideas of a passage to a student, and help out in solving conflicts. To express that a story has a start, middle and ending.
14 Subjects: including ESL/ESOL, reading, Spanish, English
Miami, FL
...If the subject matter is a business class, my expertise comes from direct experience, as I was VP of Sales and Marketing where I took a company from less than 5M to 500M and made them the leader within their marketplace. I've also been Managing Director of this country's largest seller of fine a...
17 Subjects: including ESL/ESOL, English, reading, writing
Miami, FL
...I have also presented at conferences. I have also participated in Speech and Debate competitions and am a member of Toastmasters which is a non profit organization where you develop public speaking and leadership skills through practice. I taught a career planning and development class at an Ad...
62 Subjects: including ESL/ESOL, English, reading, Spanish
Fort Lauderdale, FL
...The ESOL student can use the dynamics of the "other" language to enrich English speech and writing, and also learn English by comparative knowledge. I have worked with ESOL students from all ages and backgrounds. I believe that my own ESOL experience, my teaching experience, and my achievements...
19 Subjects: including ESL/ESOL, Spanish, writing, French
Miami, FL