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Here's what Time wrote me:The MP-470 phase 1 (single agent) trial did not demonstrate consistent PK/PD. This means that as the drug dose when up, the blood levels did not consistently rise. The PK/PD curves have been in our last two MP-470 poster presentations. This may or may not be important to our future development of MP-470 because the 1b study of MP-470 (use in combination) is escalating doses of MP-470 and demonstrating signs of activity at the lowest levels. We have highlighted a few of these patients in our presentations. As a result, we are continuing our phase 1b trial while we develop a new formulation that might be able to deliver consistently higher levels of drug and explore the effects of our drug, on patients, close to a maximally tolerated dose (MTD). Because of this dual track, we are not sure how far this might push out our phase 2. The original milestone was to start a phase2 trial this year. That milestone will go out until at least mid 2009. Timothy L. EnnsSVP Corporate Communication & Business DevelopmentSuperGen(925) 560-2810 Office(925) 551-6491 Fax(925) 719-2143 Mobile
"Because of this dual track, we are not sure how far this might push out our phase 2. The original milestone was to start a phase2 trial this year. That milestone will go out until at least mid 2009."Billy, has Supergen management stated that it will delay the phase 2 in any of its public announcements or investor presentations before you received this from Tim Enns? Do you think that a delay of the MP470 phase 2 is a material development that should be disclosed in a more comprehensive manner?This is the second drug where formulation has become a limiting issue for achievement of milestones. I believe it has also delayed S110 for at least a half a year. The company has not updated any report on progress of S110 formulation. Does the climb algorithim not take drug solubility and potential serum level into account. For MP470 Is this an availability problem or a metabolism problem?
suppergen,No, they have not released this to the public, however they did mention the reformulation, so I guess we're to put the piece's together. Mp-470 was not a Climb drug and neither was S110. I have not heard of any reformulation issue's with S110. We'll have to see how they explain the problem in a few weeks at the next quarters update. Maybe you can get Tim to comment on this issue.
Billy,What is PK/PD? Also, does this mean that MP-470 is not a viable drug as a stand alone compound and needs to be combined with other compounds to move forward?Thanks
Pk/PD is used to measure how much of the drug is in the blood. If you increase the mg, you would expect a increase of the drug in the blood stream. But they're not seeing that as a single agent. It means that the body only absorbs some of the drug. They had one response as a single agent and several in combination. On Oct 21-24, supg will present data at Eortc-Nci cancer conference from the ph1b. Combination seems to be the best direction, mp-470 inhibits several pathways and with the low tox, is a perfect combination drug.


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German Lutherans mourned with their country after Robert Enke, a top goalkeeper for the national soccer team, committed suicide in November. Lutheran Bishop Margot Kaessman, first female head of the nation's Protestants, conducted the funeral service for Enke, who struggled with depression and had lost a 2-year-old daughter to a heart disorder in 2006.
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Streamlined styling and smartly placed features add up to a minimalist footprint. Sized to fit laptops with up to 17 inch displays with practical organization for everything else you need to carry.
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Excellet backpack
This review is from: Case Logic Black 17" Laptop Backpack Model VNB-217
Pros: I've been using this backpack for over a year and consider this the best backpack I have ever used. The padding is great, it is on the sides, front, back, top, AND on the bottom. I wanted something that would hold some extra papers and notebooks, but not something very bulky. I also wanted something discrete (I hate backpacks with bright colors anywhere). This fits the bill perfectly. I bring it everyday on my commute to work and also for all of my business travels.
Cons: This is nit picking, but I would like to have some more pockets in the front compartment. It has three pockets now with some pen holders and business card holders.
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Good basic pack
This review is from: Case Logic Black 17" Laptop Backpack Model VNB-217
Pros: Great basic pack that handles my 17 inch laptop very well.
Cons: None.
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Poor Padding
This review is from: Case Logic Black 17" Laptop Backpack Model VNB-217
Pros: it's a backpack
Cons: Padding has gaps, so your computer falls inbetween the bottom padding
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Great Backpack, Very Reliable
This review is from: Case Logic Black 17" Laptop Backpack Model VNB-217
Pros: Fits everything I need and provides great protection for my laptop. Plenty of room for extra stuff I don't need.
Cons: Not really a con, but it's not extraordinarily comfortable, it does get the job done though.
Other Thoughts: So far, in a day, I've stuff this thing with 3 days worth of clothes, random art supplies, and my laptop. Surprisingly each compartment held together quite well and my machine (in its own compartment) didn't feel crushed at all. To clarify there are 2 large padded compartments where you can place your laptop or tablet, a slightly smaller compartment for books and pens, a really small zip-up pocket in the front, and of course the mesh bottle holster.
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very good for 17 inchers
This review is from: Case Logic Black 17" Laptop Backpack Model VNB-217
Pros: -Very Light.
Cons: not yet.
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Unless you can find the Nikon 1 S2 at a ridiculously low price, we suggest you spend a little more money on stronger mirrorless cameras like Sony's A5000.
Sacrificed at the altar of the J4
Excellent pocket camera - Impressive speed, level of control, and build quality
Sharp lens, Impressive images through ISO 1600
Better JPEG image quality
Great image quality
Lot of shooting options
Very, very good but not 'great'. 24mm-1,000mm lens, Wi-Fi & GPS but no RAW
Video is surprisingly smooth and sharp in the top 1080/30p mode
Flexible LCD screen
Overall a GREAT camera with just a couple minor misses
Sharp OLED display, Built-in Wi-Fi with remote viewfinder support
Waterproofing and shock-proofing
Good photo quality for its class, Responsive performance in most respects
Impressive zoom range for its size and weight
Another great camera from Nikon
Very sharp lens, 22x zoom range, Short shutter lag
Best travel-zoom camera, adding wi-fi connectivity, GPS tracking
30x zoom lens, a high-res 3-inch LCD
Great camera
Ease of use, simplicity
8fps burst and lots of other continuous modes, 180 and 360 degree panoramas
Good camera, could use some updates
Good zoom range, Compact, easy to grip body
Good build, design and handling
Small, lightweight pocket camera
Compact design makes it truly pocketable
Produces sharp enough images
Slim, Good macro mode
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Take a darker approach to occasion dressing in this retro-inspired black brushed lace skater dress. Featuring semi-sheer half sleeves, V neck and fit and flare shape.
The lace on the bottom of this dress looks really nice. I would totally wear this layered with a chunky sweater.
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Seda France White Narcissus Candle: In Greek mythology, the beautiful but vain Narcissus spent his life staring at his own reflection in a shimmering pool of water, and the stunning flowering plant that sprang up in that very spot was his namesake. Seda's White Narcissus is no less stunning or entrancing, with the warm sweetness of cassis accompanying the flower's lusty, spring-like scent along with a delicate arrangement of tuberose, gardenia and rose, and just a pinch of deep musk to round out an exceptional creation.
Packaged in Seda France's wildly popular pagoda box, each hand-poured candle in this collection is so gorgeously packaged, it doesn't even need gift wrapping.
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Ninjas are known for being sneaky, but some are so good that they can wear shiny disguises and still be effective. If you're that good then put on the Silver Mirror Ninja Child Costume and prepare for stealthy combat. The costume includes a top, pants, tunic, wrist cuffs, ankle cuffs, hooded mask, and gloves. The top and pants are solid black, and the silver trimmed v-shaped tunic fits over it. It has wide shoulders, reflective silver plates, and a silver dragon on it. The wrist and ankle cuffs are also reflective silver. The full hood mask covers the entire head and has a visor you can see out of but reflects for anyone looking at you. Black gloves cover your hands. Add your own shoes, not included, and you'll be completely covered from head to toe. The sword is not included, but we have lots of ninja weapons you can get separately, including a cool ninja action blade that pops open and a set of light up color changing nunchucks. Even if you're not really a martial arts expert, you'll look and feel like one when you wear the Silver Mirror Ninja Child Costume.
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Mohegan — In a sign that it's intent on diversifying outside the gaming industry, the Mohegan Tribe announced Friday that it has signed a deal with a Harrisburg, Pa.-based restaurant chain to open at least 15 franchised restaurant locations throughout New England over the next five years.
Under the agreement, the tribe will open the first Arooga's Grill House and Sports Bar on reservation land adjacent to Mohegan Sun, the tribe's flagship casino.
The deal is one of several nongaming initiatives the tribe is pursuing and the only major one to be made public.
In a statement, Kevin Brown, the Mohegan tribal chairman, hailed the partnership with Arooga's, the tribe's first franchising venture.
"We are thrilled to bring this incredible sports bar concept to the New England area," he said. "Arooga's reputation for being the next great restaurant franchise is well earned and we are privileged and pleased to have them as an important part of our organization."
A new tribal-government department that the Mohegan Tribal Council created to investigate opportunities beyond gaming and hospitality pursued the deal, according to Chuck Bunnell, the tribe's chief of staff. Phil Cahill, the tribe's chief operating officer, oversees the department, which is headed by Jeanette Ziegler, Bunnell said.
"They're looking at all kinds of initiatives, from high tech to manufacturing; it runs the gamut," he said.
In 2011, the Mohegan Tribal Gaming Authority, which manages the tribe's gaming operations, including Mohegan Sun and Mohegan Sun at Pocono Downs in Wilkes-Barre, Pa., formed Mohegan Gaming Advisors to pursue management opportunities in the gaming industry. Mohegan Gaming Advisors now manages Resorts Casino Hotel in Atlantic City.
Economic pressures have taken a toll on casinos in recent years, prompting both the Mohegans and the Mashantucket Pequots, who own Foxwoods Resort Casino, to increasingly focus on developing alternative revenue streams. An 80-store outlet mall is under construction at Foxwoods, while Mohegan Sun announced plans last year to add retail, entertainment and dining options to its Uncasville property.
Arooga's — the name is derived from the sound of the Model T car horn — operates eight corporate-owned restaurants in central Pennsylvania, including three in Harrisburg, and plans to open a ninth this summer in Shippensburg. Founded in 2008, the company expects to rapidly expand beyond Pennsylvania, largely through franchising.
Arooga's was named "America's Next Top Restaurant Franchise" in a 2010 competition involving more than 250 entrants from 36 states.
The Arooga's at Mohegan Sun is to be built across from the tribe's public safety building in a parking lot off Sandy Desert Road, which is off Route 32. It will encompass 9,000 square feet of space and include a separate bar area, a large outdoor deck for dining and fire pits for social gatherings. It will feature more than 100 big-screen TVs and offer some 40 domestic and craft beers on tap.
Cincinnati-based FRCH Design Worldwide is designing the restaurant, which is expected to open before the end of the year. Existing Arooga's locations employ from 50 to 100 people, depending on the size of the restaurant.
"We are excited to announce this agreement with the Mohegan Tribe," said Keith Swade, Arooga's director of franchise development. "They are a world class organization and a leader in the hospitality and gaming industry. We could not ask for a better partner to develop the New England market for Arooga's."
Mohegans branching out; tribe diversifies nongaming portfolio
Pawcatuck woman charged with DWI after chasing down school bus, other driver
Four Robinson siblings all part of same Stonington High graduating class
Two former foster children thriving in Old Lyme, Groton now advising state DCF
Rain cancels Noank and Niantic parades, decision on Mystic parade will be made Monday morning
Lillie B. Haynes principal retires after nearly four decades as educator, administrator in East Lyme
UConn wins AAC baseball tourney and earns automatic NCAA bid


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Moderator or not; free site or not; it's time to stop. It's troubling for people to NOT be able to confront it and then call a spade a spade without people usurping their power as moderator and controlling said confrontation. There is a difference between a free flow of information/conversation about ISU stuff and people being just plain irresponsible about individual's lives. Time for facts about people's indiscretions to take priority over sake of salacious story lines.
I'm using the site feedback forum and I've used no names.
As the site rules state, if you have a problem with a post/member, report the thread. The tools are there for a reason.
What is not acceptable are personal attacks that continue to happen here. Jeremy shut the site down for a short period earlier this week for that very reason. I'm sure he won't shy away from doing it again should he deem it necessary.
He's put in place the framework to check & balance everyone - members and moderators alike. You can either use those tools and have your opinions/views received well or violate the rules of the site and not have them heard.
It's up to you.
I utilized this forum that states it's for site feedback. I think there is plenty of 'feedback' to go around and those options you mentioned do not allow for others to voice their opinion on if they feel this is a need. I named no names in my feedback and kept it generic.
I'm not sure what all the personal accusations have to do with my feedback, as I've made none.
Originally Posted by cyflyer
I utilized this forum that states it's for site feedback. I think there is plenty of 'feedback' to go around and those options you mentioned do not allow for others to voice their opinion on if they feel this is a need. I named no names in my feedback and kept it generic.
I'm not sure what all the personal accusations have to do with my feedback, as I've made none.
You were given a brain that allows you consider or dismiss information as you see fit. The whining about "rumor mongering" is getting tiresome on this site.
I've got to agree with flyer on this. This site doesn't seem to be the same one that started a year ago. I haven't donated a boat load of money to Jeremy, but unless the direction that CF has taken changes I won't be donating anymore.
Ligthen up Frances....
Who seriously gets offended by anything said on an online message board?
All of you need to stop whining and deal with the fact that there are gonna be people who don't take the angle you deem fit.
Are you seriously gonna ban someone or shut down the site because someone doesn't have evidence to back up a claim?
I think everyone needs to stop worrying so much about being civil on an internet message board. This isn't elementary school.
BTW - i haven't seen any of these "personal attacks" that keep being mentioned. It's not an attack on someone's character to post a rumor floating around campus or the city. It should simply be up to you to choose to believe it or not.
The site gets shut down, and people get ****** because of threads like this. The intentions may not have been that way starting off, but doesn't mean it cant get there. We have all seen how threads get off course.
So for this reason, you need to do what ISUFan22 mentioned earlier. Report or PM the appropriate people necessary for your voice to be heard. Until then, this thread is closed!
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I was dx at 10 weeks after a big bleed with a very large tear...i think it was 7.4X7.7. Then, at my next ultrasound, it had grown. So, for 2 months I was on modified bedrest, and got my good news at 20 weeks when the ultrasound tech could not see it at all!!
Now, my concern is my doctor, who literally told me that this was so uncommon and absolutley knew nothing about it (I was informing HER). And who did not even react at my appointment yesterday about my SCH being resolved. I dont even think she studied my ultrasound (which was 2 weeks ago) and if I hadn't broughten it up, I dont think she would have. She is pretty scatter-brained, I have noticed. I really think that she did not even remember that I had an SCH. I also have gestational diabetes, she at least remembered that.
I am 22 weeks now and considering switching practices all together. Anyone do this when they are this far along in the pregnancy?


text: Ohio Department of Natural Resources Flooding Victims and ODNR Before State Supreme Court Over Compensation By Associated Press • Apr 30, 2014 The state is responding to complaints by dozens of landowners near Ohio's largest inland lake who say compensation for flooding losses has been delayed again. Second Body Recovered From Buckeye Lake By Jim Letizia • Apr 1, 2014 Authorities have found the body of a second boater who drowned in Buckeye Lake after a fishing boat capsized last Friday. Ohio Department of Education "Hit List" Claim By Ohio Public Radio • Mar 26, 2014 A month ago, questions were raised about an alleged list of people at the Ohio Department of Natural Resources who were supposed to be treated as enemies. ODNR Shuts Down Drilling Site After Early Morning Earthquakes By Alison Holm & Associated Press • Mar 10, 2014 State regulators ordered a gas drilling company to halt operations today after four minor earthquakes shook an area 20 miles south east of Youngstown. ODNR Investigations Reintroducing Sturgeon To Lake Erie By Alison Holm & Associated Press • Mar 3, 2014 Ohio Department of Natural Resources The Ohio Department of Natural Resources is looking into whether it can reintroduce breeding populations of sturgeon to Lake Erie. State Seeks Public Input On Hunting Proposals By Mike Foley & Associated Press • Feb 24, 2014 State officials are seeking public comment on hunting, trapping and fishing regulations proposed for 2014 through 2015. Lawmakers Targeted In ODNR Communications Plan Respond By Ohio Public Radio • Feb 18, 2014 Two state lawmakers were listed as adversaries in a state agency's plan to promote drilling in state parks. Document Shows Influence Oil And Gas Drillers Have On State Lawmakers, Policy By Jim Letizia & Ohio Public Radio • Feb 18, 2014 An environmental group has discovered a controversial plan by the Ohio Department of Natural Resources to tackle oil and gas drilling issues. More Coyote Sightings In Central Ohio By Jim Letizia • Feb 7, 2014 State wildlife officials say they're getting more calls about coyotes in suburban Columbus. Officials Say Ohio's Bobcat Population Rebounding By Associated Press • Jan 13, 2014 Ohio Department of Natural Resources State wildlife officials are asking to remove the bobcat from Ohio's threatened species list. Drillers Get More Oil And Gas From Ohio By Jim Letizia • Jan 3, 2014 Ohio energy companies extracted more than twice as much oil and gas from the Utica shale during three months last year than all of 2012. Local Deerkeeper Reaches Deal With State By Jim Letizia & Ohio Public Radio • Dec 19, 2013 A Mount Vernon woman who has been fighting for months to keep some injured deer in her enclosed back yard says she has reached an agreement with the Ohio Department of Natural Resources. Shale Drilling Permits For 2013 Surpasses Expectations By Ohio Public Radio • Dec 16, 2013 2013 saw more than twice as many drilling permits issued for the Utica Shale than first expected. Inspector General Cites More Wildlife Officers By Mike Foley & Associated Press • Dec 13, 2013 The state watchdog is referring 18 more Ohio wildlife officers for possible criminal prosecution after a follow-up investigation into illegal hunting while on duty uncovered additional cases. State Trying To Increase Population Of Hellbender Salamanders By Jim Letizia & Ohio Public Radio • Dec 3, 2013 The state is trying to bring back the population of North America's largest amphibian. The hellbender salamander lives in streams hard hit by water pollution in the 1970s. Dredging At Grand Lake St. Marys Exceeds Goals By Associated Press • Nov 22, 2013 Natural resource officials say they have exceeded dredging goals this year for Ohio's largest inland, which has been plagued by toxic algae outbreaks. ODNR Considers Need For More Oil And Gas Well Inspectors By Ohio Public Radio • Nov 18, 2013 Ohio Department of Natural Resources Companies continue to grow their natural gas production from Ohio's shale formations, and state inspectors play a key role in defending communities and the environment. State Considers Storage Lagoons For Fracking Wastewater By Alison Holm • Oct 29, 2013 State officials are considering rules for storage sites containing fracking wastewater. Local Student Injured In Crash By Jim Letizia • Oct 29, 2013 Delaware County Sheriff's deputies say a 17-year-old girl was hospitalized this morning for treatment of injuries sustained in a crash with a state pickup truck. Report Details Environmental Damage From Fracking By Jim Letizia • Oct 8, 2013 A study of government records quantifies the environmental damage caused by fracking. Pages« first ‹ previous 1 2 3 next › last »


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Photo GalleryMeet American Idol's Top 20!
The first cuts have been made: Now get to know Melinda Doolittle, Chris Richardson and the rest of the Idol Class of 2007
Credit: FOX
Updated: Friday Feb 23, 2007 | 06:00 AM EST
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Cole improved to 4-1 on the season and tossed his third consecutive complete game in blanking the Spartans 5-0. In five of seven innings he retired the side and allowed just three hits on the day. Last weekend he was on the short end of a tough 1-0 loss at Hawai'i tossing a complete game. The week prior to the UH game he pitched his first complete game in the Silver & Blue as Nevada defeated Fresno State 14-4.
While Cole was keeping SJSU off the scoreboard the Pack offense gave him an early 3-0 lead after one inning of play. With one down second baseman Cullen Mahoney tripled and first baseman Shaun Kort walked. Mahoney scored on a double steal as Kort moved to second base where he scored on left fielder Nick Melino's double. Right fielder Brian Barnett followed with a single moving Melino to third base where he scored on third baseman Garrett Yrigoyen's single up the middle
In the fourth inning catcher Michael Turay led off the inning hitting his first home run of the season and it was 4-0. Center fielder Westley Moss followed with an infield single then stole second and third base. Kort's sacrifice fly plated Moss with Nevada's fifth and final run of the game.
Cole (4-1) did not walk a batter and struck out three to earn the win. Sean Martin (0-2) was tagged with the loss allowing five runs on eight hits in 3.2 innings on the mound.
Melino (2-for-3,R,RBI) had two hits to lead the offense and extended his hit streak to 10 games which is one off his career-high set this season. He had a career-high 11-game hit streak then failed to get a hit and now has a hit in the last 10 games giving him hit in 21 of the last 22 games. Kort, Melino, Turay and Yrigoyen had an RBI each in the game.
Three different SJSU batters collected hit in the game.
The two teams conclude the series with a single game on Sunday at 1:00 p.m.
Burns continues international run in China
Monday, June 29, 2015 - Women's Basketball
Wolf Pack golf alums qualify for the U.S. Open
Monday, June 8, 2015
A letter from Doug Knuth: Much to be proud of for Wolf Pack fans
Thursday, May 28, 2015 - General
Pack women's golf signee Collom wins state tournament
Thursday, May 21, 2015 - Golf
Letter from Doug Knuth: Questions and answers about our 2015 football schedule
Monday, March 9, 2015 - Football
Pack puts on clinic for local children in Puerto Vallarta
Friday, March 6, 2015
Former Nevada coach headlines Boys and Girls Club Dinner
Friday, January 30, 2015 - General
Christenson earns spot in World Cup rifle competition
Wednesday, January 14, 2015 - Rifle
Pack freshman Surin races against her Olympic medalist father
Tuesday, January 6, 2015 - Track and Field
A letter to Wolf Pack fans from Doug Knuth: Successes on the field and in the classroom.
Monday, January 5, 2015 - General
Former Nevada track & field standout Hanson passes away
Tuesday, December 23, 2014 - Track and Field
Tonight's Wolf Pack basketball game will feature "Kindness Minute"
Saturday, December 13, 2014 - General
A letter to Wolf Pack fans from Doug Knuth: Mackay Stadium renovation approved
Friday, December 5, 2014 - Football
Wolf Pack Fans, Reward Yourself and the Team
Monday, November 17, 2014 - Football
Wolf Pack women's basketball hosts free skills clinic
Monday, November 10, 2014 - Women's Basketball


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MARFU Div III Rugby Championships
April 19-20, 2008 Harrisburg, PA
Photography by Tom Wenger and Paul Kruis
A pictorial representation of the 2008 MARFU Div III Rugby Championships that took place in Harrisburg, PA over the April 19-20 weekend.
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10 Steps to Pick the Right Doctor
Whether you need a primary care doctor or a specialist, these 10 steps will ensure you find the right doctor for you. View Slideshow
Dr. Hoey's Experience
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Dr. Hoey does not have any procedures listed. If you are Dr. Hoey and would like to add procedures you perform, please update your free profile.
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- Graduated in 1998
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- English


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Balloon fiesta fills skies over Albuquerque
the Mass Ascension for Balloon Fiesta went off Saturday morning with clear skies.
the Mass Ascension for Balloon Fiesta went off Saturday morning with clear skies.
More rain is on the way for Charleston, SC, where streets are already flooded and surf is well above normal.
Wanted subject believed to be inside the residence
Police closed the intersection of East Princess Anne Road and North Military Highway early Saturday morning, and advise drivers to avoid the…
A gunshot victim walked into Sentara Norfolk General Hospital early Saturday morning.
WAVY Sports Director Bruce Rader presents Friday Night Flights.
Neighbors in the Ocean View section of the city spent Friday night cleaning up after water flowed into several homes.
In this week's episode of the Old Dominion Football Show, coach Wilder looks back at ODU's shutout loss vs. Appalachian State and ahead to i…
Sentara says someone stole two portable hard drives containing patient information from operating rooms at the Heart Hospital.
The N.C. Department of Transportation announced that N.C. 12 on Ocracoke Island has been closed due to sound-side flooding.
Police in Norfolk are investigating a home invasion that occurred early Thursday morning.
Find out what's behind the shush heard around the world.
Put on your masquerade mask and support those suffering with Breast Cancer at the upcoming Breast Cancer Survivors Masquerade Gala
Get a taste of the south and head to Scoot's BBQ in Gloucester Point.
She kicks game winners and throws touchdowns for the Presidents football team.
All over the Peninsula it was the same story: tidal flooding coming into yards and homes.


text:
John's Tropical Chicken Salad
Total Time
1hr 10mins
Prep 10 mins
Cook 1 hr
Roasted Chicken salad great for warm season picnics.
Ingredients Nutrition
6-8 6-8 Sandwiches US
- 4 large chicken breasts (smoked or roasted ahead of time)
- mango
- low-fat mayonnaise
- ground cloves and nutmeg
- fresh basil and gingerroot, chopped
- sliced almonds
- Once the the chicken is cooled, shred it into small pieces.
- Peel and cube the mango in to small pieces.
- Mix all ingredients into a large mixing bowl.
- Serve cool on sandwiches or as a side.


text:
Celebrity Gossip & Entertainment News Leaders ®
Believe it or not, the Texas mother who has gone viral with her Chewbacca mask video scored a spot on "The Late Late Show" alongside host James Corden and another very special guest.
Candace Payne can't stop cracking up as she listens to her Star Wars toy, which turns out to be quite disturbing for Corden, who just wants to get his commute underway. James laments, "I have got to get to work. Is there any way we can leave now?" Payne replies, "I'm such a happy Chewbacca!"
Photo Credit: CBS
She's a certified bada** in her own right, and now Gillian Anderson is getting a push from the Twitterverse to star in an upcoming 007 film.
The "X-Files" babe received a respectable response from the recent #NextBond vote, with a few fans even creating posters to depict Anderson as "Jane Bond."
Photo Credit: Twitter
Adding another animated attraction to the slew of great films on deck, Illumination Entertainment just released the new preview trailer for "Sing."
Slated to hit theaters on December 21st, 2016, the project includes big name stars like Reese Witherspoon, Scarlett Johansson, John C. Reilly, Matthew McConaughey and Seth MacFarlane.
Photo Credit: Universal Pictures
Continuing to raise the ante on streaming services, Netflix just announced they've struck a deal with Disney that takes effect this fall.
In a new blog entry, Netflix content honcho Ted Sarandos declared, "From September onwards, Netflix will become the exclusive US pay TV home of the latest films from Disney, Marvel, Lucasfilm and Pixar."
Photo Credit: Disney
They've been at odds for years, however on Monday afternoon (May 23) Justin Bieber gave a sign that his beef with Taylor Swift may be coming to an end.
The "One Less Lonely Girl" posted an Instagram video of himself singing Swifty's 2006 song "Teardrops On My Guitar," and shortly after uploading the clip, Taylor clicked 'like!'
Photo Credit: Instagram
It's time to catch up with our "Finding Nemo" friends, and it seems Disney Pixar has a brand new preview trailer for their much-anticipated "Finding Dory."
Starring Ellen DeGeneres, Albert Brooks, Ed O'Neill, Kaitlin Olson, Michael Sheen, Eugene Levy, Diane Keaton and Ty Burrell, the animated project is scheduled to dock in theaters on June 17th.
She's been busy promoting her new film "X-Men: Apocalypse," and last night (May 23) Jennifer Lawrence paid a visit to "The Tonight Show Starring Jimmy Fallon."
The "American Hustle" hottie looked gorgeous as she kicked off a round of Fallon's famous game "True Confessions," along with "Last Week Tonight" host John Oliver.
Photo Credit: NBC
Scoring yet another amazing gig, Karlie Kloss is the new face of Swarovski as Miranda Kerr's contract comes to an end.
Swarovski's chief executive officer Robert Buchbauer told Women's Wear Daily, "We wanted to bring our brand to the next level but also the next generation — we thought that Karlie would be a perfect match. She represents a certain openness and a certain mind-set — a new philosophy if you will. She is very fashionable and very beautiful, which is key when you talk about the next generation of consumer — specifically, powerful women who should become our long-term customer. On top of that, we've decided to put more emphasis on the North American market and who would be better than Karlie?"
Photo Credit: Swarovski
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text: Grays Harbor PUD Restores Hoquiam Power Outage November 5, 2009 HOQUIAM, Wash. – The Grays Harbor PUD Reports they have restored a small power outage that affected about 30 customers from L to 5th Street. Liz Anderson tells us "The night is young." GHPUD Tweets Subscribe to RSS headline updates from: Powered by FeedBurner Comments


text:
May 15, 2016From Seller: ClieOS
Good transaction.
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Fantastic person to deal with, didn't make any fuss and was prompt with payment. You can be sure dealing with him would be a pleasure.
Item: Flare Audio R2A
Dec 19, 2014From Buyer: sherry1218
Seller is a very nice person. The dita is excellent.
Jun 9, 2014From Buyer: swervinmonks
Good communication. Item came as described. Would do business with again.
May 14, 2014From Buyer: AL3X
Great seller. Very fast shipping and honest communication. Spent the time to give me a well thought out description of the sound signature of the DBA-02 MKii's compared with another headphone we've both owned. Highly recommended!
May 10, 2014From Buyer: CosaNostra
Great Seller. Item came in perfect condition as promised.
May 2, 2014From Buyer: ebrian
Awesome guy, very friendly and reasonable.
Apr 25, 2014From Buyer: Allanmarcus
great communication.
Apr 25, 2014From Buyer: HiFlight
I purchased a FitEar F111 from this seller. In all respects, this was a flawless transaction. He promptly answered all my pre-purchase questions and shipping was fast. The phones were well packed and arrived safely in absolute mint condition! AAA+++
Jan 29, 2014From Buyer: Twinster
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Jan 4, 2014From Buyer: manatworks
item is in pristine condition, lovely gift that my dad will love it for sure. also taking his time to answer all of my question and very fast shipping. Awesome Awesome Awesome
Nov 28, 2013From Buyer: infinity650
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Sep 7, 2013From Buyer: darthian123
The seller is really patient and helpful. The item was sent promptly, even included a little gift along with the brilliant earphones:) A very, very smooth deal:)
Aug 1, 2013From Buyer: bobfoc
Fast and efficient. Item as described. Many thanks
Jul 27, 2013From Buyer: Nulliverse
Very efficient and professional seller - excellent communication and a credit to the community.
Jun 18, 2013From Buyer: Tamirci
Great package and great seller there. Recommended.
Item: FS: Budget-Fi IEMs
Apr 23, 2013From Buyer: tsm28
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Item: FS: Budget-Fi IEMs
Apr 3, 2013From Buyer: Greed
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Item: FS: Heir Audio 4.A -SOLD
Nov 19, 2012From Trader: Vlooienuker
23t23dS is a great person to deal with! Easy and fast trade, highly recommended!
Nov 1, 2012From Buyer: f3d0r4
The amp is as described Quick postage & reasonable postage fee. Will not hesitate to buy from him again :) Thanks!


text:
Your location is outside the National Library of Australia. Resources you can access:
|Show by title
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Royal Society Publishing: The Royal Society is the world's oldest scientific publisher and its archive is the most comprehensive in science. Its journal archive, comprising more than 69,000 articles and dating back to 1665 is available online and all articles more than 70 years old are permanently free to access. Titles covered include the following: Biographical Memoirs, Biology Letters, Interface, Interface Focus, Notes and Records, Open Biology, Proceedings, Proceedings A, Proceedings B, Philosophical Transactions, Philosophical Transactions A, Philosophical Transactions B.
European Commission: The Archives Portal Europe provides access to information on archival material from different European countries as well as information on archival institutions throughout the continent.
eScholarship Research Centre, University of Melbourne: Digital copies of maps relating to Australia found in John Arrowsmith's London Atlas, which through successive editions, had a life of 24 years, from 1834 until 1858. Also includes references to the appearance of these maps in publications other than the atlas and as part of Arrowsmith's map stock available for individual purchase.
: An extensive collection of both imagery and scholarship, this gateway covers art history from the prehistoric to the 20th century. It also has links to research resources, art departments, museums and galleries.
AsianLII provides for searching and browsing databases of legislation, case-law, law reform reports, law journals and other legal information, where available, from all 27 countries and territories in Asia . Over 140,000 cases from at least 15 countries, and over 15,000 pieces of legislation from at least 18 countries are searchable. For every country, AsianLII contains an extensive Catalog of law-related websites for that country, and a Law on Google facility assisting users to search Google only for legal materials from that country.
A global collaborative project which provides access in bibliographic and in hypertext terms to networked scholarly documents, resources and information systems concerned with or relevant to Asian Studies.
: The Atlas is a national collaboration between the CSIRO, Australian museums, herbaria and other biological collections and the Australian Government. It has been developed to provide more comprehensive and accessible information on Australia's biodiversity. It aims to enable anyone to locate, access and combine information on all aspects of Australian biodiversity, online. The information provided includes reference lists of species in different groups, databases of information on specimens held in natural history collections, databases of field observations from ecologists, naturalists and others, images and other multimedia, published literature, molecular data sets, identification keys and a wide range of other databases and web sites.
NSW Land and Property Information: Interactive atlas of New South Wales. Allows users to navigate around a digital map of NSW and explore maps of the Census 2006, Population, Heritage Sites, Agriculture, Elections, Crime and History.
IP Australia: Searchable database of Australian patents dating back to 1904. The full text of patent applications is available via the AusPat database, managed by IP Australia, the Australian Government agency that administers intellectual property (IP) rights and legislation relating to patents, trade marks, designs and plant breeder's right
: AusStage records information on live performance in Australia. It includes information on the name or title of the event, venue, date, production company and primary genre. It also contains biographical information on Australian theatrical performers.


text:
|Número de publicación
|Tipo de publicación
|Número de solicitud
|Fecha de publicación
|16 Sep 1986
|Fecha de presentación
|13 Jun 1983
|Fecha de prioridad
|13 Jun 1983
|Número de publicación
|Ronald B. Luther, Pradip V. Choksi
|Cesionario original
|Luther Ronald B, Choksi Pradip V
|Exportar cita
|BiBTeX, EndNote, RefMan
|Citas de patentes (5), Citada por (27), Clasificaciones (6), Eventos legales (4)
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet
This invention relates to a new and improved blood oxygenator having an improved, reuseable heat exchanger and a dual sparger system for increasing oxygenation efficiency and CO2 removal.
Blood oxygenators are usually designed with the intent of using components that are premanently secured in the device, the principal one being the heat exchanger. This item constitutes one of the major expenses in a blood oxygenator; however, after use, the heat exchanger is usually discarded along with the body of the oxygenator. If the heat exchanger could be readily detached from the blood oxygenator and reused, the cost of the equipment would be reduced considerably. Also, since fewer heat exchangers would be required overall in a particular facility, they could be manufactured to a much higher quality than if they were mass produced. This in turn would reduce the possibility of producing a defective component, and also would reduce quality control costs. A replaceable heat exchanger should be capable of quick and easy removal from the oxygenator and connecting water lines. Also, the movement of cooling water through the heat exchanger should be simple and efficient, and preferably with little opportunity for scale build up.
In the case of a finned heat exchanger, the transfer efficiencies of oxygen will depend on the amount of finned surface available for contact between the blood and the oxygen bubbles. Hence, a heat exchanger configuration having spirally wound fins should increase the residence time for the blood and improve oxygen transfer efficiencies compared to a finned heat exchanger having parallel fins. Similarly, a spirally wound finned heat exchanger is preferred for efficiency of heat exchange.
In U.S. Pat. No. 4,254,081, the inventor herein described an elliptically shaped heat exchanger for a blood oxygenator having spirally wound fins. However, it is not practical to manufacture such a device (as opposed to a heat exchanger having parallel fins) because of severe fin distortion along the major axis of the ellipse.
Blood oxygenators require an efficient oxygen uptake into the blood, and an equally efficient CO2 removal. However, the most effective mean sparger pore size for oxygen uptake is about 1μ, and the most effective mean sparger pore size for CO2 removal is about 40μ, with a wide mean variation. Heretofore, this disparity in pore sizes made it difficult to simultaneously achieve both effects in a single sparger because a gas will move along the lines of least resistance, namely along the paths adjacent the largest pores.
According to the invention, a blood oxygenator having the option of a replaceable heat exchanger is provided. The heat exchanger is of circular cross section and is produced as a hollow, integrally formed aluminum extrusion having external, spirally wound fins which are uniform and undistorted. The heat exchanger is enclosed in a container that functions as a blood reservoir and oxygenation portion in conjunction with the heat exchanger. The container is attached to a blood processing unit that removes CO2 and acts as a defoamer and blood collector. The heat exchanger is removeably mounted such as with a snap-on lock and/or threaded connection to cooling and/or heating water supply outlets. Upon completion of a surgical procedure, the heat exchanger container can be easily removed from the oxygenator container and disconnected from the water supply. It is then cleaned, sterilized and reused.
A dual sparger is provided to supply both O2 and CO2 plus O2 to the blood as it enters the spaces between the spiral fins, causing different sizes of bubbles to form, depending on the pore sizes of the two spargers. This pore size differential enables an efficient oxygen uptake and CO2 removal.
FIG. 1 is an external perspective view of the oxygenator of this invention;
FIG. 2 is an external view, partly in perspective, of the heat exchanger of this invention and associated container;
FIG. 3 is a cross section view in plan of the sparger of this invention, taken along the lines 3--3 of FIG. 2;
FIG. 4 is an exploded, external perspective view of the sparger components; and,
FIG. 5 is an end view of the heat exchanger of this invention taken along the lines 5--5 of FIG. 2.
The blood oxygenator 10 of this invention is shown in FIGS. 1 and 2, and comprises a heat exchange container 11 into which is fitted a heat exchanger 12, the container and heat exchanger being sealed by a removeable plug 13. The container 11 is adhesively bonded to a blood processing unit 14, and is in fluid communication therewith. Oxygenation and heat exchanger takes place within the container 11 and between the fins of the heat exchanger, and the temperature controlled blood passes in a foam condition to the blood processing unit 14, where it is defoamed, degassed and is collected as liquid, oxygenated blood in a single phase.
Both the oxygenation and heat exchanger 11 and the blood processing unit 14 may be manufactured from a suitable transparent plastic such as General Electric's "LEXAN" polycarbonate resin, or a semi-transparent plastic. A water supply connection 16, that will be described, infra, is attached into the heat exchanger.
The bottom portion 17 of the container 11 is provided with a sparger 20 including a manifold 21 fed by inlets 22, 23 and 24 for O2, CO2 plus O2, and venous blood respectively. The O2 inlet 22 feeds into an inner circular outlet 25 in the manifold, while the CO2 plus O2 inlet 23 feeds into an outer circular outlet 26. The venous blood inlet 24 feeds tangentially into a central outlet 27; this improves gas mixing and reduces injury of blood cells due to head-on impact with the manifold walls.
As shown in FIG. 4, porous, sintered rings 30, 31 of high density polyethylene, teflon, ceramic, glass beads, and the like are mounted within the outlets 25, 26 and are secured by a retainer 32 that is bolted to threaded bosses 33, 34. As indicated, the pore sizes of the rings 30, 31 are manufactured, preferably, at about 1μ and 40μ respectively, to produce O2 and CO2 plus O2 bubbles, that are of the desired size. Of course, these pore sizes are preferred, not mandatory. The rings 30, 31 also enable suitable gas pressures to be developed at the outlets 25 and 26. Flow rates for the O2 and CO2 plus O2 are about 1-6 liters/min.; the CO2 content in the gas stream may vary up to 100%.
Oxygenated blood having a controlled concentration of both O2 and CO2 is passed along the heat exchanger and out of the container 11 as a foam through an exit port 35 (about 180° from the sparger inlets) and into the blood processing unit 14 through an entry port 35A. The blood is then defoamed, degassed and collected as whole, oxygenated blood.
The heat exchanger 12 is manufactured as an integrally formed, round aluminum extrusion having external, spirally wound fins 41. The interior of the heat exchanger defines a hollow, centrally and axially aligned chamber 42 having spirally formed fluted walls 43. A portion of the fins are machined off at the open upper end 44 to form a round, cylindrical neck 45 defining a machined, inwardly curved, locking arm engaging portion 46; the neck 45 has a length of about 4-6 inches. The bottom closed end 47 of the heat exchanger is machined flat.
Cooling or heating water is passed through the hollow chamber 42 and is directed in a spiral fashion by the fluted walls 43 to reduce turbulence. Typically, a total of about 15-24 external fins are used, each fin has an end width of about 0.045 inches, an interior width of about 0.9 inches, and is about 0.5 inches in depth. The fins have a spiral wind of about 20°-35°, and the heat exchanger length measured along the fin portion is about 11-14 inches. The overall diameter of the heat exchanger (fin-to-fin) varies from about 2 inches to 2.5 inches, the unobstructed internal diameter of the fluted, hollow chamber 42 is about 0.5-1.0 inches, and the wall thickness is about 0.15 inches. For pediatric work, the fin dimensions and overall size of the heat exchanger will, of course, be smaller. Preferably, the fins make a close fit with the interior side wall of the container. This prevents movement of blood out of an adjacent pair of fins and results in good heat exchange and oxygen transfer.
The water supply system 16 for temperature control of the heat exchanger comprises a water inlet line 50 that is threaded or otherwise attached to an open ended coupling 51 having an inlet 52, a bell shaped interior 53, and locking arms 54. An extension pipe is attached to the inlet line 50 and extends through the coupling 51. An annular space 56 is defined between the inlet 52 and the extension pipe, and the annular space feeds to an outlet pipe 57. As shown in FIG. 2, the extension pipe 55 is inserted into the heat exchanger chamber 42, and the cylindrical neck 45 of the heat exchanger is inserted into the bell-shaped interior 53 of the coupling 51. The arm engaging portion 46 of the neck coincides with the locking arms 54. Hence, when the arms are closed, as shown, the water delivery system 16 will be water tight, and will also form a strong mechanical connection with the heat exchanger. Movement of cooling water through the system is shown by the arrows. It will be appreciated that cooling (or heating ) water is passed along the pipe 55 downwardly, and coaxially and centrally along the heat exchanger chamber 42 countercurrent to the flow of blood. This arrangement makes for a more efficient and uniform heat transfer. At the conclusion of a surgical procedure such as a coronary by-pass, the heat exchanger can be readily disconnected from the water supply system.
The blood processing unit 14 for oxygenated blood is shown in FIG. 1 connected (e.g. by glue bonding) to the container 11. The unit 14 is molded in two corresponding halves 14A and 14B that are edge sealed by solvent sealing or heat sealing. The unit 14 may be manufactured from a transparent plastic such as "LEXAN" polycarbonate resin or a similar material, as in the case of the container 11. The processing unit 14 has an overall oblong shape, and a central, inwardly curved portion 58 that fits with the round container 11. The capacity of the processing unit 14 is about 3-4 liters. An entry port 35A connects with the exit port 35 of the container. The upper front portion of the processing unit 14 forms an outwardly configured reservoir portion 61 where defoaming and degassing occur. Defoaming takes place by passing the blood foam through a coarse, open-cell polyurethane foam 59 and a nylon mesh (150-225 mesh) 62 that has been coated with a defoaming agent. Polyester and steel mesh also may be employed. The nylon or steel mesh is secured between the edges during sealing to accurately position the mesh and to prevent foam from leaking around the edges. If steel mesh is used, it can be heated by induction to assist in the edge sealing.
Lower reservoirs 63, 64 are provided for collecting whole blood, and these are integrally molded to the front of the blood processing unit 14. An inlet port 65 may be provided for connecting to a cardiotomy reservoir (not shown) and a CO2 vent 66 is located upwardly of the degassing reservoir 61. An optional sample port 67 is located on the lower side of the reservoir 63, and outlet ports 68, 69 for oxygenated blood are positioned on the lower side of reservoir 64. For convenience, either one of the outlet ports 68, 69 may be used, depending on the orientation of the blood oxygenator relative to the patient.
During use, venous blood is fed through inlet 24 of the sparger 20 into the manifold 21, and through the central outlet 27 into the bottom of the container 11. The venous blood then moves upwardly through the container and between the spirally wound fins 21 of the heat exchanger 12. Simultaneously, water is passed through the hollow chamber 42 of the heat exchanger in the direction shown by the arrows for controlling the blood temperature, depending on the patient's condition. O2 and CO2 plus O2 are fed through their respective inlets 22, 23 and outlets 25, 26 and rings 30, 31 to the bottom 17 of the container 11. The gases form bubbles that are absorbed by the blood as it passes upwardly between the fins and the container wall. The spiral winding of the fins enables a longer contact time to be made between the heat exchanger and blood, and also increases the oxygenation time of the blood as compared to a finned heat exchanger having only parallel fins.
As the blood reaches the upper end of the container 11, it becomes saturated with these gases, and turns foamy. This blood foam is then passed through the exit port 35 and into the blood processing unit 14 through the entry port 35A. The blood foam is broken down by the polyurethane foam 59 and mesh 62, and this causes CO2 and miscellaneous gases such as O2, anesthetic gases, etc., to be vented through the CO2 vent 66. The defoamed, oxygenated blood 70 is collected in the reservoirs 63, 64 and returned to the patient through one of the outlets 68, 69.
At the conclusion of the operation, the heat exchanger 12 is removed from the container 11 and is disconnected from the water supply system 16. The heat exchanger is then cleaned and sterilized, after which it is ready for reuse. It will be appreciated that reassembly of the heat exchanger into a new container 11 will take place usually at the hospital, or in the operating room. Hence, production costs at the manufacturing end will be reduced. Also, since fewer heat exchangers are required, quality control can be improved with little corresponding cost increases. Furthermore, because the same few heat exchangers will be used in a facility, their individual characteristics become better known to the perfusionist.
|Patente citada
|Fecha de presentación
|Fecha de publicación
|19 Oct 1977
|10 Jul 1979
|Heat exchanger-blood oxygenator combination
|16 Oct 1978
|1 Ene 1980
|Texas Medical Products, Inc.
|Blood oxygenator assembly method
|21 Sep 1979
|3 Mar 1981
|Research Partners Limited
|Blood oxygenator
|3 Abr 1980
|15 Feb 1983
|Gambro Heart-Lung Products Ab
|Apparatus for the transfer of one or more substances between a gas and a liquid
|22 Jul 1981
|4 Oct 1983
|Wilkinson William R
|Blood oxygenator
|Patente citante
|Fecha de presentación
|Fecha de publicación
|7 Jul 1988
|17 Oct 1989
|Baxter International Inc.
|O2 /CO2 control in blood oxygenators
|12 Dic 1990
|28 Abr 1992
|Houston Advanced Research Center
|Intravenous fluid temperature regulation method and apparatus
|20 Oct 1988
|9 Jun 1992
|Baxter International Inc.
|Integrated membrane blood oxygenator/heat exchanger
|10 Feb 1992
|23 Mar 1993
|Houston Advanced Research Center
|Intravenous fluid temperature regulation method and apparatus
|10 Mar 1992
|6 Jul 1993
|Baxter International Inc.
|Integrated membrane blood oxygenator/heat exchanger
|20 Jul 1995
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|Medisystems Technology Corporation
|Reusable blood lines
|18 Feb 1997
|12 Ene 1999
|Dideco S.P.A.
|Container for blood
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|Dsu Medical Corporation
|Reusable blood lines
|18 Sep 2000
|16 Sep 2003
|Dsu Medical Corporation
|Reusable blood lines
|6 Dic 2002
|23 Dic 2003
|Dsu Medical Corporation
|Method of using reusable blood lines
|7 Dic 2010
|Lifebridge Medizintechnik Ag
|Apparatus for making extracorporeal blood circulation available
|30 Oct 2006
|29 May 2012
|Lifebridge Medizintechnik Ag
|Apparatus for making extracorporeal blood circulation available
|7 Dic 2010
|10 Sep 2013
|Zoll Lifebridge Gmbh
|Apparatus for making extracorporeal blood circulation available
|8 May 2012
|29 Oct 2013
|Zoll Lifebridge Gmbh
|Apparatus for making extracorporeal blood circulation available
|7 Dic 2010
|13 May 2014
|Zoll Lifebridge Gmbh
|Cardiopulmonary apparatus and methods for use during PCI and CABG
|7 Dic 2010
|16 Sep 2014
|Zoll Lifebridge Gmbh
|Cardiopulmonary apparatus and methods for preserving organ viability
|7 Dic 2010
|11 Nov 2014
|Zoll Lifebridge Gmbh
|Cardiopulmonary apparatus and methods for preserving life
|28 Oct 2013
|10 Feb 2015
|Zoll Lifebridge Gmbh
|Apparatus for making extracorporeal blood circulation available
|22 Nov 2005
|8 Jun 2006
|Lifebridge Medizintechnik Gmbh
|Apparatus for making extracorporeal blood circulation available
|30 Oct 2006
|17 Jul 2008
|Lifebridge Medizintechnik Ag
|Apparatus for making extracorporeal blood circulation available
|15 Abr 2008
|14 Ago 2008
|Timi 3 Systems, Inc.
|Systems and methods for applying ultrasonic energy to the thoracic cavity
|11 Abr 2008
|28 Ago 2008
|Timi 3 Systems, Inc.
|Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue
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|Gerhard Brieske
|Apparatus For Making Extracorporeal Blood Circulation Available
|7 Dic 2010
|25 Ago 2011
|Lifebridge Medizintechnik Ag
|Cardiopulmonary Apparatus And Methods For Preserving Life
|25 Ago 2011
|Lifebridge Medizintechnik Ag
|Cardiopulmonary Apparatus And Methods For Use During PCI And CABG
|24 Abr 1997
|11 Jul 2000
|Baxter Healthcare Corporation
|Cylindrical blood heater/oxygenator
|5 Sep 1995
|6 Mar 1997
|Helmdach Anke Dipl Produktdesi
|Medizinische Anlage
|Clasificación de EE.UU.
|Clasificación internacional
|Clasificación cooperativa
|Clasificación europea
|27 Nov 1989
|Fee payment
Year of fee payment: 4
|26 Abr 1994
|Maintenance fee reminder mailed
|18 Sep 1994
|Lapse for failure to pay maintenance fees
|29 Nov 1994
|Expired due to failure to pay maintenance fee
Effective date: 19940921


text:
Category: The Agile Mind
Never Put Off Till Tomorrow What Can Be Done the Day After
A fundamental truth in life is that there'll always be more to do than we'll have time or money to do.
And although projects are (arguably) a part of life, some Project Managers/Customers/Clients still believe they can defy this fundamental truth by introducing Agile – and then using it as an excuse to make unrealistic demands from delivery teams/suppliers.
However, the goal of Agile is not to deliver everything that the customer wants…
…the goal of Agile is to deliver the most important things that'll give the customer the greatest value and earliest return-on-investment. In so doing, Agile aligns with Pareto's 80/20 Principal i.e 20% of the things we do will give us 80% of our results.
So with that in mind, the next time you're faced with a set of requirements that do not fit within your projects times and/or budget constraints, prioritise the important ones for delivery now; and defer the least important ones until a later date.
A Good Plan Is Better Than a Perfect One
In an ideal world, things would always go to plan – but since we don't live in an ideal world, they don't; hence why the best-laid plans of project managers often go awry.
More often than not, detailed plans laid out on neat charts projecting months (even years) into the future, tend to describe a fictional reality; and perfect plans tend to describe fictional realities perfectly. Because no matter how much time, effort and care goes into planning a project, sooner or later, something's likely to deviate from the plan.
That's not to say we shouldn't plan – we should.
But instead of trying to create a 'perfect plan' in detail upfront, it's better to start with a plausible plan and refine that plan throughout the lifetime of the project; because when you refine your plans to reflect reality (rather than trying to get reality to reflect your plans), you're more likely to achieve your project objectives.
The 'Dysfunctional Agile' Trap
The growth of Agile in the public and private sectors has led to many cases of dysfunctional Agile – where organisations are mechanically going through the motions, but are failing to realise the benefits Agile has to offer.
At best, those companies that fall foul of the dysfunctional Agile trap are finding it frustratingly hard and costly to transition to Agile; at worst they're losing significant market share.
And when this happens, 'Agile' gets the blame.
The Problem With Agile…
A common problem I constantly encounter with people and organisations struggling to get Agile to work for them is this…
They're focusing on the wrong things – whilst ignoring the key fundamentals that make Agile work.
Now, if your goal is just to slap a few 'Agile' labels on what you've always been doing, and you have no desire to reap the Agile benefits of higher profits, lower costs, improved quality and quicker time to market, then I wish you well…
…Just remember that Einstein defines madness as "doing the same thing over and over again and expecting different results."
But if you recognise that in today's fast paced, highly competitive business world, agility is not only essential for retaining market share and business survival, done properly, it can also give your company a significant competitive advantage, lower risk exposure and earlier return on investment, then watch this video…
Proof Agile Doesn't Work
Whilst recently attending a networking event, I was asked what I do, to which I replied I'm an Agile & Lean consultant.
Being this was not a software development related event, my response was met by blank faces; until one of the group I was speaking to (who I'll call 'John' for the purpose of this post) commented that "agile is a project management methodology used in software development."
Feeling this was not the time to be pedantic, I agreed that agiles' roots can be traced back to software development – adding that agility has since become a strategic approach for cutting costs, getting an earlier return on investment and gaining a competitive advantage, widely used across many industries.
John then asked if we could catch up later to talk 'agile' as his organisation was considering adopting it.
"Sure" I said, "Let's do that."


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Oklahoma football: The Oklahoman's OU-Iowa State picks
Here is a look at how our crew picked Saturday's game:
BERRY TRAMEL, Columnist
* OU 31, Iowa State 15: Dom Whaley returns from the Federal Witness Protection program.
JENNI CARLSON, Columnist
* OU 31, Iowa State 17: This would be a trap game if not for OU's less-than-stellar performance last week. The Sooners will be motivated.
JASON KERSEY, OU beat writer
* OU 35, Iowa State 17: Oklahoma finds itself in a close struggle with the Cyclones at halftime, but pulls away in the second half to win relatively comfortably.
STEPHANIE KUZYDYM, OU beat writer
* OU 35, Iowa State 17: Trey Millard gets the touches and Jalen Saunders gets the catches to lead Oklahoma both on the ground and in the air.
RYAN ABER, OU recruiting
* OU 35, Iowa State 21: The emergence of Jalen Saunders continues as he finds the end zone for the first time in a Sooners win.
MIKE BALDWIN, Beat Baldwin
* OU 31, Iowa State 21: Cyclones defense is good but not good enough to pull off patented upset in Ames.


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- Differential Diagnosis
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Differential Diagnosis For Ultrasound/Liver multiple solid tumors, Family history/Bulging eyes/proptosis
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- Adenocarcinoma, colon
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- Carcinoma, bronchogenic
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Since Alex Brink's first start as a redshirt freshman in 2004 at Reser Stadium, something about the Oregon State defense has given the Cougars...
PULLMAN — Since Alex Brink's first start as a redshirt freshman in 2004 at Reser Stadium, something about the Oregon State defense has given the Cougars quarterback nightmares.
In the senior quarterback's final start at Martin Stadium on Saturday, Oregon State made it an ending to forget for WSU's all-time leading passer, who will leave without playing in a bowl game.
Brink was forced into six interceptions, tying a WSU record, in what was probably the worst game he has played in a 52-17 loss.
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"This is a bad feeling right now," Brink said. "We had such a great opportunity coming into these final two games."
The Cougars, who fell to 4-7, end their season Saturday at Husky Stadium in the Apple Cup.
"I have so much respect for that guy," Oregon State coach Mike Riley said. "He's had a tremendous career, and I'm very proud of what he's done. I'm just glad he didn't do it tonight."
Oregon State linebacker Derrick Doggett felt for Brink.
"You hate to see him end his season like that," he said. "He's been so great."
The Beavers have always haunted Brink. Thirteen of his 43 career interceptions have come against Oregon State. In 2004, Brink was 15 of 41 for 201 yards and two interceptions in a 38-19 loss. That game dropped the Cougars to 3-4, which gave WSU its first losing record since 2000.
In 2005, Brink threw for a school record 531 yards against the Beavers, but four second-half interceptions helped turn a 30-13 WSU lead into a 44-33 loss.
The 2004 and 2005 losses hurt WSU's bowl hopes. This one put an end to them, and any chance Brink had to punctuate his place in the team record book.
It appeared WSU was catching OSU's defense at the right time. The Beavers were without three defensive backs — starters Brandon Hughes and Bryan Payton and backup James Dockery — in the first half after they were ejected in the second half of last week's 29-23 win over Washington.
But it didn't matter because the OSU front seven generated a lot of pressure on Brink, forcing him into quick throws and bad decisions.
"We forced him to throw those picks," said Cougars right guard Dan Rowlands. "He was getting hit from all over the place. Their defensive ends were a lot quicker than we thought. It's our fault that we weren't blocking good. He had to switch to a three-step drop instead of a five-step drop."
Said receiver Brandon Gibson: "When he doesn't have time, it's hard to connect on anything. Alex didn't have enough time to even think back there."
Brink knew what to expect.
"We certainly knew they were going to do that — we felt like we could counter," he said. "The pressure definitely got to us."
Brink admitted the fierce pass rush, the heavy rain and the empty bleachers Saturday night may have been the most fitting ending to his home era at WSU.
"I think today kind of signifies it for me," he said. "It's been a place of ups and downs for me. … I'd certainly love to go out on a better note than this, no doubt about that. But Martin Stadium is a place I'll never forget."


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1 Piece Suits
Leather Motorbike Race Suits
Fabulous suit but watch that knee armour
With a fairly limited range of decent race suits for women riders, the Ayana Ladies one piece is a very welcome addition to the market by Held. The two best aspects of this product for me are the quality of the materials used (the leather is soft, stretchy and a fabulous deep black colour) and the design of the suit - it's tailored to a very high standard and looks fabulous on. The only downside (and why I gave the suit a rating of 4) is that the rigid knee protectors (not the knee sliders but the triangular knee armour pieces) have a fairly sharp inside edge to them which produced some surface scratches on the side of the tank of my brand new GSXR 750....As you can imagine I wasn't right happy... I've emailed Held about it and sent some pictures and they have been really co-operative and are looking into it but my advice, if you haven't got knee grips/tank pad protection on your bike is to either be very careful about how tightly you grip your tank with your knees (on sports bikes this is almost unavoidable though) or perhaps cover the edges with a soft material (I've put a small bit of masking tape over them for now). Size wise I normally take a 10 and I found the UK 12 to be a comfortable fit. On the whole a great suit and one of the best I've seen and worn for a while notwithstanding the issue with the knee armour!Nikki, North Yorkshire - Camblesforth
Great comfort on the bike
Snug fit to begin with but definitely moulding itself after a couple of uses, breathes well in warm conditions and isn't too cold either! Great comfort on the bike not so great for off the bike, good zips and Velcro! I put off buying this for ages but glad I went for it well worth it!Oliver Whyte - Dunkeld
Great product, excellent purchase
The suit fits exactly how is given in the size chart of Alpinestars. The suit is amazing, precise work on the suit, the materials used are top quality. It is very good for new riders who want to gain new experience in riding a motorcycle, and riders on the track. It looks very aggressive and good, it feels very comfortable and nice, the movement in it is very good, the position on the bike with the suit feels great. Alpinestars products are just great and top level, also Sportsbikeshop are incredibly fast with sending and changing products. Really good job!Ivo - Leeds


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Disconnected battery lights went off. Drove car a a couple of kms and heard noise underneath, then solid metal sound and lights came back on. Please note that this is a 2008 Montero Sport assembled in Japan 6V 3000cc 24V, not an Eclipse.
by wild12 in Ensenada, PR on March 29, 2013


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[Video] Added Korean drama 'Cruel Palace - War of Flowers' final episodes 49 and 50
Collusion wracks the royal court when the ambitious concubine Soyong Jo (Kim Hyeon-joo) plots to make her son, Prince Bongrim (Kim Joo-yeong), the crown king. The only problem is that there is already someone else in line: Crown Prince So Hyun (Jeong Seong-woon) - not to mention all those that stand in the way of Soyong Jo's diabolical plans. They say a mother will do anything for her child, but to what end?


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A new TV station backed by Venezuela's government began transmitting yesterday in various countries across Latin America, carrying praise...
CARACAS, Venezuela — A new TV station backed by Venezuela's government began transmitting yesterday in various countries across Latin America, carrying praise by Venezuelan President Hugo Chávez, the U.S. actor Danny Glover and others.
The Telesur network, which organizers call a Latin alternative to large media outlets like CNN, was being seen in Argentina, Uruguay, Bolivia, Brazil and Cuba as well as Venezuela, Chávez said.
"This is part of an awakening of our peoples," Chávez said by phone to a televised inaugural ceremony in Caracas. Chávez, a close ally of Cuban leader Fidel Castro, called the channel a key step toward regional integration.
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The station, financed by Venezuela and also backed by Argentina, Uruguay and Cuba, has drawn concern in the U.S. Congress, where House members last week approved a measure to transmit radio and television broadcasts to Venezuela to ensure citizens receive "accurate news."
Chávez has ridiculed the U.S. plan and has said Venezuela is prepared to jam the broadcasts. He also said Venezuela would prevent any signals from interfering with Telesur's programs.
The president likened the satellite channel to the cooperative oil projects Petrosur and Petrocaribe, aimed at sharing Venezuela's fuel with neighboring countries under preferential terms.
He said U.S. leaders, through seeking conflict with his government, want "to assure themselves" Venezuelan oil.
"We want to keep supporting the American people to the point that we can, supplying them energy, but not only to large U.S. companies, or the established power in Washington," said Chávez, whose country remains a major supplier to the United States.
Some critics call Telesur a way to spread anti-American propaganda in South America — an accusation strongly denied by Venezuelan Information Minister Andres Izarra, the station's president.
"It's an initiative against imperialism," Izarra said. "That shouldn't be interpreted, however, as an initiative against the American people."
The station, headquartered in Caracas, is to offer news programs, opinion shows, documentaries and Latin American films. It is to be on the air four hours a day at first, and eventually 24 hours a day. Test transmissions began two months ago.
Some in Colombia already have expressed concern about promotional footage that used a protest scene in which Colombian rebel leader Manuel Marulanda briefly appeared.
But director Aram Aharonian of Uruguay has brushed aside such criticism, saying the channel will support independent journalism.
Glover, a station board member and strong supporter of Chávez, said the station has a key role acting as a counterbalance to the "giant to the north."
Other advisory-board members include the Nobel Peace Prize winner Adolfo Perez Esquivel and the Uruguayan writer Eduardo Galeano.


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This panel was recorded April 6, 2011, as part of the China and International Law Symposium sponsored by the Confucius Institute and the University of Chicago Law School.
Joe Alesia is an Executive Counsel, Global Investigations at GE where he conducts and manages internal investigations across all of GE's businesses, including matters related to the Foreign Corrupt Practices Act ("FCPA"). Prior to his time with GE, Joe was a Managing Director at Stroz Friedberg LLC, a cybersecurity, digital risk management, and investigations firm.
When James Cole, '95, was growing up in a neighborhood not far from the Law School, his family was often strapped for cash. "We were on welfare more than we were off of it," he recalls. "I remember having big blocks of government cheese delivered to our house." As a youngster he sold candies at his church, and he liked the feeling of making a contribution to his family's well-being.
Michael D. Friedman was formerly Managing Director at Ocean Tomo, LLC, an intellectual property focused merchant bank, where he headed its Asset Management business, served as Chief Investment Officer, and headed Investment Banking. Prior to joining Ocean Tomo, Mr.
This moderated panel will feature three Chicago-area public interest law attorneys, each at different stages of their careers. Come hear these practitioners discuss their career tracks, highlight issues related to transitioning between firms and public interest, and answer questions.
Douglas Wilber, '10, Staff Attorney, Chicago Legal Clinic
The Law School recently announced a redesign of its Loan Repayment Assistance Program (LRAP). This new program and its predecessor program are intended to alleviate the debt burden of our graduates who work in public interest. Have questions about it? Wonder which program – the new or former LRAP -- is right for you?
The Public Interest Law Society and the Office of Career Services are pleased to announce the 2011 PILS Awards. Come and honor the winners of the 2011 PILS Awards ($500 prize): one member each of the 2L and 3L classes will be chosen by a panel of public-interest alumni judges.
Also: UCLaw Pro Bono Pledge Sign Up Table
As a kick-off to Public Interest Law Week, the Public Interest Law Society (PILS) invites you to hear a distinguished panel of attorneys discuss their pro bono matters. Come learn how these lawyers structure public interest practices within their law firms:
Holly Snow, '09, Associate, Paul Hastings
Kelly Huggins, Staff Attorney, Sidley Austin
Prof. Maria Woltjen of the Law School's Immigrant Child Advocacy Clinic and several of her students discuss their experiences over the past year, including work on a field report on human trafficking in China.
Prof. Charlotte Walker, head of the Human Rights Department at the University of Chicago, considers the impact of migration and criminal laws on sex trafficking—and vice versa—using in particular data and information from the EU, Turkey, and the Near East.
University of Chicago Law School 1111 East 60th Street, Chicago, Illinois 60637 773.702.9494 ContactDirections & Accessibility


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Helping You Navigate Law School
The University of Dayton School of Law is committed to helping you navigate law school. At the start of your first year, you will be assigned a faculty advisor who can provide guidance on course selection, exam preparation and career opportunities. Each full-time faculty member serves as the official advisor to a small number of students throughout those students' years at the Law School.
Many faculty members also serve as informal advisors to students who are not specifically assigned to them. You are encouraged to also seek out faculty members who teach in the areas that interest you for guidance and advice. All professors have set office hours each week when they are available for drop-in visits; students may also call or email professors to arrange for an appointment.
In addition, every incoming first-year student will be assigned to a Learning Community comprised of 8-10 first-year students and led by a Dean's Fellow. Dean's Fellows are high-performing, upper-level students who are committed to modeling and supporting the development of the professional qualities of excellence that the Law School cultivates and expects for incoming students. Dean's Fellows meet with their Learning Community members first during orientation and then weekly throughout the first semester of law school. Dean's Fellows supplement the advising offered by faculty and often help students to address academic adjustment and social issues.
The Law School also hosts a number of informational sessions for students during the school year. In the past, these sessions have included discussions about courses, career paths, and clerkships.


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Posts from Pillows & Throws
Shine On: Sequin Decor
How To Wash a Pillow by Hand or Washing Machine
Apartment Therapy Tutorials
Can you remember the last time you washed your pillow? It's generally a good idea to do it at least once each year to keep them fresh, clean, and free of dust mites. Whether you wash by hand or machine, this simple task will put your mind at ease and literally help you sleep at night.
5 Decadent Blankets I'm Dying to Cozy Up With
My weather preferences were primed in my hometown of San Francisco, where hoodies are worn year-round, seasons are the stuff of storybooks, and the couple weeks of blue skies and temperatures in the 70s mean that everyone playing hooky can be found on Ocean Beach. Now we're in Tallahassee, Florida, and when temps plummet to 70, my kids beg for their jackets with whines of "I'm freeeezing!!" Acclimation is a real thing. But that's fine with me: It means I can turn on the fire and snuggle up in blankets like these.
Chunky Wool Blankets to Buy or DIY
At the top of my wish list for this fall is a giant chunky knit wool blanket. I keep seeing them on Scandinavian design blogs, and every time I do I take a minute and imagine how wonderful it would feel to be snuggled up underneath a blanket that feels like a giant wool sweater for your entire body. So I've hunted down a few sources for these enormous lovelies, and also a few DIYs for those of you brave (and talented!) enough to make your own.
In a DIY mood? Try this easy and beautiful jar painting project:
Can a Pillow Keep You Wrinkle Free?
Short answer: who knows? But come along anyway as I delve into the engrossing and somewhat terrifying world of specialty sleep pillows.
Currently Coveting: HYM Salvage Mud Cloth Collection
If you are a fan of both mud cloth and modern furniture, you might want to check out the recent collaboration between Philadelphia based design company HYM Salvage and Urban Outfitters. Helena Young-Meyer of HYM Salvage updated vintage furniture with vintage mud cloth to make new one-of-a-kind pieces. Currently there is a small collection of furniture available, as well as a few pillows and poofs.
Pure Beauty: Undyed Wool in the Contemporary Home
I just purchased a new rug for our hallway and am pleased as punch with it. It's a runner from Colonial Mills' Shear Natural collection. The entire collection is woven of undyed wool fibers, meaning that every colorway happens to be the colorway of a sheep! From creamy whites to warm brownish grays to black, there's beautiful variety in undyed wool.
IKEA Hack: How to Make a Moroccan Style Pillow from $2 Dishtowels
Apartment Therapy Reader Project Tutorial
Gah! Summer sent over this oh-so-simple IKEA hack that's a perfect quick project. I had a slap-myself-on-the-forehead kind of moment, because why didn't I think to do that? Summer also added a kind-of-genius twist at the end, utilizing those fabric loops on the dishtowels, originally used for hanging in the kitchen. Check it out.
Summer Decor: 5 Sweet Popsicle Pieces
These looks are especially sweet if you're decorating for kids, but they're also fun and quirky if you're just decorating for yourself.
Pillows for a Summer Look
So you know that advice that you should stick to neutrals when it comes to the big investment pieces and have fun with accessories? It's great advice — just make sure you don't end up with a big beige filled room. This post is all about the 'have fun' part. Your couch is probably one of the bigger furniture investments you're going to make, so definitely stick with a neutral if that makes you comfortable, but you can easily change up the pillows with the seasons. Here's a roundup of some great themes and pillows to bring a little summer into your living room.


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nuisancenoun [C or U]uk /ˈnjuː.səns/ us /ˈnuː.səns/
B2 something or someone that annoys you or causes trouble for you: I've forgotten my umbrella - what a nuisance! [+ -ing verb] It's such a nuisance having to rewrite those letters. I hate to be a nuisance, but could you help me? Local residents claimed that the noise was causing a public nuisance.make a nuisance of yourself
More examples
- It's a cursed nuisance, having to work late every evening!
- "Was he a nuisance?" "No, not at all."
- Far from being a nuisance, she was a positive joy to have around.
- Peaceful demonstrations that do not cause a public nuisance are a fundamental right in any truly democratic country.
- She's a terrible nuisance.
synonyms and related words:
You can also find related words, phrases, and synonyms in the topics:


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Charles Hice
Dead Poet Two Thousand Fourteen - Poem by Charles Hice
Dead Poet Two Thousand Fourteen
Dead Poet Two Thousand Fourteen
solyant green the 666 is money the dollar sign the number on the bill the id card the birth date and now the phone number all these are important but not the end of time will come after time has wound down look at the sun it is a yellow sun not red it gets red science will tell you when it ages
when the moon turns to blood the light of the moon is only the reflected light of the sun as it burns in the form of the gaseous ball of fire we see a yellow sun this gives people light health and strength when it starts to turn red it might dwarf or grow into a giant the color is the key to the end when it is red it is almost over the time will be shorter the days length only a third of the day will we see anything people will be suffering more they will be animals again the mind will be gone the hive mind will be gone only monkeys intent on survival and fighters will advance up to the tower of Babel and preach new ways of murder uniform living one size fits all with the mark of the beast on the visible mind and hand me no money will no longer be needed only an access point me to the door way let me inside to those material goods pudding and soap clothing and food out the door way too home is a spot on the walk no more hope chasing the poor with no mark dragging mee upp the stairs steppes to the scaffolding holding upp the killers guillotine blade will take my worthless head off and send my soul to Jesus to be remade. God grant me the strength to be ready to die to refuse the mark of the beast let me become truley free a child of the living Jesus set me free let me be free the price of life is set too high no heart no love no life only the asking price of murder in the long cold night of sky turning red for more then a few hours obscuring the clouds unseen the fire coming mingled with ice the misery of EgYpt the frog spirits of the dead mentioned in the Book Of Revelations eye paid 30 pieces of SIlver to JUdas to be hangged he might be the ABomination of DEsolation mentioned will be coming to the Temple area someone has to be the AntiCHrist when it will happen perhaps the SUn will be dying before that day ever comes not one day but about 3500 of them this has been a fact filled missive but you must understand what do eye mean eye do not quote facts and figures when eye write it is from a dead poet vision Dead Poet Two Thousand Fourteen
Topic(s) of this poem: art
Poet's Notes about The Poem
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Thunder-Lakers: The Lakers played Game 2 the way they wanted, until it all came undone
The Los Angeles Lakers got what they wanted in Game 2 against the Thunder on Wednesday night.
Keep the game in the 90s or lower – nothing in triple-digits – implored Lakers forward Pau Gasol after getting shellacked 119-90 in Game 1 on Monday.
"Foul them a couple more times (and hope) the refs won't call it," Kobe Bryant suggested on Tuesday, evidently not kidding.
Slow down the tempo and throw in some missed open jumpers from the home team and, presto, the series would be tied at 1-1.
Instead, the game went presto-chango.
With two minutes left in the game, the Thunder had scored just 68 points and the Lakers led by seven.
In the final two minutes, OKC outscored the Lakers 9-0 and won 77-75 in front of a frenzied sellout crowd of 18,203 at Chesapeake Energy Arena.
The 77 points were the fewest the Thunder has scored in a victory since arriving in Oklahoma City from Seattle in July 2008.
An ugly game could have been a picture-perfect victory for the Lakers.
Instead, they trail 2-0 going into Game 3 at 9:30 p.m. Friday at Staples Center.
"We're pretty disappointed because we played a really good game to get that lead," Lakers guard Steve Blake said afterward. "They took it from us, but we gave it away at the same time. We've got to be more solid down the stretch."
In typically perplexing fashion, Lakers forward Metta World Peace said: "We'll be all right. We had a lot of good things happen tonight. I don't want to say exactly what happened."
The somewhat inexplicable happened:
- The Thunder scored just 18 points in the first 22 minutes of the second half. In Game 1, OKC scored 39 points in the third quarter alone.
- In Game 1, the Thunder had four turnovers total. In Game 2, guard James Harden (five) and forward Kevin Durant (four) had at least four each.
- The Thunder shot 50 percent in the first half (18 for 36) and 33 percent (11 for 33) in the second half on Wednesday, and still won thanks to the Lakers shooting 38.5 percent for the game and 13.3 percent (2 for 15) from 3-point range.
Despite crumbling in the final two minutes, the Lakers still had one final shot to tie or win.
With 5.7 seconds remaining, the Lakers ran a flare play for a pass to go to Bryant on the far side of the court.
Bryant appeared to be well-covered by Thabo Sefolosha with Serge Ibaka helping off a pick. However, LA coach Mike Brown later described Bryant as "wide-open on the back side."
Bryant said: "I don't know what Metta saw."
Meanwhile, Blake stood alone in the right corner just 15 feet away from where World Peace inbounded the ball.
Thunder defender Russell Westbrook inexplicably had his backed turned to Blake and quickly turned to contest the shot.
"I was there to be an outlet for them, and my man kind of ran away from me," Blake explained. "I'm going to take that shot. It was a good look. I just happened to miss it this time.
"Once I let it go, I kind of knew it was to the right a little bit."