text:
Group Booking Terms and Conditions
Because you are making a Group Booking, there are additional Terms and Conditions that apply. Please read them and click 'I Accept' below to continue with your booking
Hostel Specific Terms & Conditions
The remainder of the amount due will be charged to your credit card 1 week prior to arrival. Should numbers or room selection change, the per person deposit times the number of people who actually travelled will be deducted from the total accommodation charge levvied by the hostel.
The following group types are not accepted by this hostel: Junior / Primary School, Stag/Hen/Bachelor Party If you have misrepresented the type of group you are booking for, your booking may be cancelled by the hostel.
Any cancellations resulting from agreement to these terms and conditions under false pretences will result in loss of deposit.
General Group Booking Terms
By making a group reservation through Hostelworld.com you agree to the following terms and conditions as set by Hostelworld.com and as set by the hostel in question.
- In order to make a group reservation on Hostelworld.com it is necessary to pay a deposit. The balance is due directly to the hostel according to their payment conditions.
- The booking deposit is non-refundable
- Hostelworld.com are not responsible for changes or amendments to your reservation once it has been processed. All correspondence with regard to changes to your booking need to be dealt with directly with the hostel.
- Cancellations for reservations must be made directly with the hostel and must conform with the individual hostels cancellation policy (see below)
- It is your responsibility to pay the balance of your accommodation cost to the hostel in accordance with their payment conditions (see below). Failure to do so may result in your reservation being cancelled by the hostel.
- Individual hostels may have special booking conditions relating to group stays, please read the hostel booking conditions carefully before making your reservation.
Binnenkort uitverkocht
Beschrijving van de Accomodatie Inrichting
Nieuwste recensie
" Location of hostel was great and a very easy walk to the old walled city. Also had great street food on plaza de Trinidad in the evenings. Breakfast was good and different each day. Staff were very helpful too. Unfortunately there just wasn't any atmosphere in the hostel when we stayed as everyone kept to themselves- luckily we met a few nice people though! "- Anoniem
Hostelworld mobiele apps
Boek onderweg met de nieuwe mobiele apps van Hostelworld.


text:
Issaquah could be the next home for Tent City 4. The Community Church of Issaquah has been working over the past several months to bring...
Issaquah could be the next home for Tent City 4.
The Community Church of Issaquah has been working over the past several months to bring the homeless camp to the city from Aug. 11 to Nov. 10, said Elizabeth Maupin, outreach minister.
"We understood the need, and part of being a good Christian is that you care for the vulnerable," Maupin said.
The church submitted an application to the Planning Department, and a draft permit is expected in 10 days, said Sandy Wirth, the city's permit and licensing supervisor.
- Power restored after major, hour-long outage in downtown Seattle
- Trump, Clinton win Washington state primary
- Designed in Seattle, this $1 cup could save millions of babies
- Seattle's vanishing black community
- Boeing plans hundreds of layoffs in local IT unit
Most Read Stories
Tent City, which has about 80 residents, would camp in the church's back parking lot, said Maupin.
The homeless encampment has often sparked community opposition when it sought permission to move to various cities on the Eastside.
But so far, nobody has protested in Issaquah, said council President David Kappler.
"We're really hoping we can avoid that," he said. "Almost everything I've heard so far from the community has been either neutral or positive."
On May 19, Tent City 4 will move from St. Jude Catholic Church in Redmond to the Episcopal Church of the Resurrection in Bellevue.
Earlier this year, St Jude helped tent-city residents set up camp at the church, despite a warning from city officials that the church was operating without a valid permit and would accrue fines starting at $350 per day. The Redmond City Council later reinstated a temporary use permit to St. Jude's.
On Friday, the city voided all fines that the church had accrued.
Sonia Krishnan: 206-515-5546 or firstname.lastname@example.com

subset: commoncrawl


text:
The two internal mics are in the upper right and upper left; the faders don't just control levels, but also write automation. I/O is on the left and right sides.
What: Turnkey guitar/vocal recording package with USB interface,
Mackie-compatible control surface, specialized Guitar
Tracks 4 DAW software with video support, built-in BOSS
COSM hardware multieffects with effects editing program,
tuner, mic input with phantom power, built-in mics, expression
and footswitch inputs. Cross-platform except for Guitar Tracks 4.
Why: Solves many problems for guitarists who want to get into
computer-based recording by offering zero latency, low cost,
ease of use, and reasonable requirements—you can even run it on
a Netbook for a highly portable live performance effects setup.
Installation: Painless. The USB interface is class-compliant,
the software that comes with it is both mature and bullet-proof,
and the control surface is obvious.
It looks like hardware, but this is the software effects editor for the onboard BOSS COSM effects.
Learning curve: Figuring out the basics is surprisingly easy,
particularly because the control surface is tightly integrated with
the software. However, Guitar Tracks 4 (a variant on Sonar Home
Studio) is quite capable for those who want to dig deeper, like
getting into detailed waveform editing—although digging deeper
means a steeper learning curve.
Best bits: Having BOSS hardware effects built-in means zero
latency when recording or monitoring, but you can record a
dry signal too if you're into re-amping. The vocal recording and
processing capabilities are also welcome, given that many
guitarists are singer/songwriters. Cakewalk has been getting
more into the Mac world, so the VS-20 can serve as a front
end/interface for programs like Logic Pro and GarageBand,
while the control aspect works with anything that supports
Mackie control. The built-in mics are a great idea for getting
ideas down in the heat of creativity; and if you find Guitar Tracks
4 too limiting, the VS-20 gives equivalent integration with other
Cakewalk Sonar-family software.
Limitations: The sample rate tops out at 44.1kHz, and the
faders are short—300mm. Of course, at this price they're not
motorized. Guitar Tracks 4 is "limited" to 32 audio tracks and
one MIDI backing track, and the outputs are RCA phono jacks.
Bottom line: At this price point, any additional complaining
would seem petty. No, you're not going to get boutique mic pres,
and if you record at 96kHz, you're out of luck. But I've found few
packages that make it this easy to marry your guitar and computer,
and the zero-latency hardware effects overcome one of
the biggest obstacles to computer-oriented guitar players—
although you can add standard VST and DirectX effects if you
want. This is an extremely well-thought-out package that gives
guitar players what they need to get started with computerbased
setups, while offering enough capability to grow.
Contact: www.cakewalk.com
More from this Guitar Recording Roundup....
Watch Eddie Van Halen and Sammy Hagar Perform Live for the First Time 30 Years Ago | VIDEO
Jaco Pastorius Documentary Coming This Fall from Metallica's Robert Trujillo | TRAILER
The Kinks to Release New 2-CD Best-Of Album, 'Sunny Afternoon' | VIDEO
Watch "Bass Technique and Discussion With Jack Lawrence" Directed by Jack White (VIDEO)
Robert Trujillo's "JACO" Film Sets Release Date
Watch Robbie Shakespeare and Sly Dunbar Lay Down Reggae Grooves (VIDEO)
Cast Album of Tori Amos Musical 'The Light Princess' Set for Release
Composer Jeff Beal Wins Emmy for 'House of Cards'
Artist to Watch: Mike Flanigin
Cream-Era Eric Clapton Explains How His Gibson 'The Fool' SG Works | Video
Dozens of Videos to Accompany Beatles' '1′ Reissue | VIDEO
Gary Richrath's Top 10 Greatest REO Speedwagon Tracks
Fit For An Autopsy Premiere Lyric Video for 'Murder in the First'
Broken Flesh Premiere New Music Video, "Consumed by Death"
Win Tickets to 'Alleluia! The Devil's Carnival' Screening
Eric Clapton Borrows The Beatles' "Day Tripper" Riff in Cover of Ray Charles' "What'd I Say"
Roy Buchanan Performs "When a Guitar Plays the Blues" — Video
Guitar Chalk Sessions: Jamming Arpeggios with the C Major Triad
Copyright ©2016 by NewBay Media, LLC. All Rights Reserved. 28 East 28th Street, 12th floor, New York, NY 10016 T (212) 378-0400 F (212) 378-0470


text:
Le Creuset 5 Piece Signature Set - Cherry - MS1405-67
Build an impressive collection of enameled cast iron quickly and easily with the new 5 Piece Signature Set, which includes the 3˝ qt. Signature Round French Oven with Lid, 1ľ qt. Signature Saucepan with Lid and 9" Signature Iron Handle Skillet.


text:
Sharp Clings to Life After Losses
Consumer electronics giant Sharp, known for its HDTVs and displays, is struggling to stay afloat after reporting huge losses in the first 6 months of this year. The company reported a 16 percent decrease in sales, resulting in a loss of over $4 million.
Related Content


text:
Some might call John McCain's pick of Sarah Palin to be his running mate unexpected -- but it definitely has people talking.
Students in an afternoon East Carolina University political science class had varying opinions when we spoke to them. Some of them said the pick of the 44-year-old governor might bring disgruntled Hillary Clinton voters over to the Republican ticket. Some democratic voters also agreed that the pick was risky, but a good choice. Others expressed concern over experience.
Palin was elected in Alaska in 2006 when she unseated the then Democratic incumbent. She's the first female GOP nominee for vice president.
The Republican National Convention is scheduled to start on Monday.


text:
Thanks a ton :) On 1/18/2012 10:35 PM, John Matthews wrote:
----- Original Message -----So ive wanted to sync a CentoS 6.2 repo to a local pulp deployment while i was on Community release 18 and hit this http://osdir.com/ml/pulp-list/2011-11/msg00063.html So I went ahead and upgraded pulp to Community Release 19 [root pulp repos]# rpm -qa | grep pulp python-isodate-0.4.4-4.pulp.el6.noarch pulp-selinux-server-0.0.254-8.el6.noarch mod_wsgi-3.2-6.pulp.el6.x86_64 pulp-consumer-0.0.254-8.el6.noarch m2crypto-0.21.1.pulp-5.el6.x86_64 pulp-admin-0.0.254-8.el6.noarch pulp-common-0.0.254-8.el6.noarch pulp-client-lib-0.0.254-8.el6.noarch pulp-0.0.254-8.el6.noarch python-oauth2-1.5.170-2.pulp.el6.noarch However now pulp fails to build 3/4 file tree's and fails with the below error http://pastebin.com/BdAnWV0M The error on my pulp-client seen is : http://pastebin.com/yPeMq2eb Id appreciate it if someone from pulp team can have a look at this and shed some more light on this -- http://dotud.posterous.com/ _______________________________________________ Pulp-list mailing list Pulp-list redhat com https://www.redhat.com/mailman/listinfo/pulp-listI saw many 403's when trying the feed you had in the pastebin. I believe this is a server side issue and not related to Pulp. I tried to recreate what you are seeing using the below feed: "http://centos.arcticnetwork.ca/6.2/os/x86_64/" pulp-admin repo create --id centos_62_x86_64 --feed http://centos.arcticnetwork.ca/6.2/os/x86_64/ pulp-admin repo sync --id centos_62_x86_64 -F Item Details: Tree Files: 2/4 RPMs: 3808/6294 Warning: 2488 errors occurred 2 Tree_File Error(s): HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64//images/install.img HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64//images/pxeboot/initrd.img 2486 Rpm Error(s): HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64/Packages/subversion-kde-1.6.11-2.el6_1.4.x86_64.rpm HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64/Packages/libselinux-2.0.94-5.2.el6.i686.rpm HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64/Packages/ctan-kerkis-sans-fonts-2.0-23.el6.noarch.rpm HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64/Packages/plotutils-2.5-7.1.el6.i686.rpm HTTP status code of 403 received for http://centos.arcticnetwork.ca/6.2/os/x86_64/Packages/wdaemon-0.17-2.el6.x86_64.rpm ... 2481 more error(s) occured. See server logs for all errors.
-- http://dotud.posterous.com/


text:
INQ Latest
Snoopers' Charter: Theresa May promises review of unpopular bulk data collection plans
Well, that's something
Microsoft axes 1,850 more staff from mobile biz as Windows Phone goes into freefall
Future of firm's smartphone business looks increasingly uncertain
Huawei sues Samsung for LTE patent infringement in Galaxy S7, Note 5 and more
Claims rival has made 'billions' by abusing patented technology
Apple plans to invent Google Home and Amazon Echo first, as usual
It's Siri, but not rearry, cos it's filling my body with rage
Microsoft ups the minimum spec for Windows 10 after Anniversary Update
Two gigs is the new one gig
News continued
Alphabet boss Eric Schmidt admits he uses an iPhone 6S
But it's OK cos he thinks the battery life is crap
Apple rehires security legend Jon Callas for encryption work
Callas to Cupertino
HPE to spin-off services unit, merge it with CSC then dump the lot in a convenient tax-free deal
Cheers, trebles and big bonuses all round
OnePlus 3 release date, price, rumours and specs
Online rep outs handset's release date as 14 June
Citrix unveils Raspberry Pi 3-based desktop thin client
Microcomputer will be able to run virtualised Windows 10 apps
Microsoft bans basic passwords because of that LinkedIn hack
Passwords like '123456' and 'Password' won't be allowed
Pebble 2, Time 2 and Core blow past Kickstarter targets
Firm currently has more than $6m in funding
INQ debate: the aftermath
What's the biggest problem with software licensing? The votes are in
OS X 10.12 features: what to expect
Siri for Mac, Apple Pay in Safari and more
MP reveals fear of imminent Terminator invasion
He's seen the film, so he's already more tech-savvy than the others
Toshiba adds 8TB model to high-end X300 hard drive range
TL;DR: AIO X300 8TB, GmbH, TEG, AF, NVQ, PMR, TMR RLT, SATA, TMI!
- iPhone 7 release date, specs, price and rumours
- Apple's 12.9in iPad Pro can now run Windows 10 apps
- Get out: celebrity WhatsApp Gold for proles is a scam
- Updategate: Microsoft uses technique to lure you to Windows 10 from the 'X' button
- Microsoft ups the minimum spec for Windows 10 after Anniversary Update
- OS X 10.12 features: what to expect
- 18-year-old Brit charged with hack attack on Mumsnet
- Microsoft to increase the price of Minecraft in the UK, but only for PlayStation gamers
- Apple rehires security legend Jon Callas for encryption work
- You too can turn your PS4 into a Linux Steam machine
iPhone 7 release date, specs, price and rumours
35 comments
Updategate: Microsoft uses technique to lure you to Windows 10 from the 'X' button
17 comments
Galaxy Note 6 UK release date, price, rumours and specs
15 comments
Windows Phone claimed just 0.7 per cent of global smartphone sales in Q1
12 comments
Apple's 12.9in iPad Pro can now run Windows 10 apps
7 comments
INQ Depth
As Android Pay hits the UK, the OS is the new language of shopping
But Denmark has gone a different way and is moving towards cashless


text:
Hamish Downer
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text:
The Leading eBooks Store Online
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Manual of CuratorshipTaylor and Francis 2015; US$ 250.00
Based on original contributions by specialists, this manual covers both the theory and the practice required in the management of museums. It is intended for all museum and art gallery profession staff, and includes sections on new technology, marketing, volunteers and museum libraries. more...
Redisplaying Museum CollectionsAshgate Publishing Ltd 2014; US$ 109.95
This is the first book to examine, in depth, the multi-million pound redisplay and reinterpretation process in British museums in the early twenty-first century. Acknowledging the importance of the Heritage Lottery Fund (HLF) as project catalyst, Hannah Paddon explains and explores the complex process, from the initial stages of project conceptualisation... more...
Manual of Museum ExhibitionsRowman & Littlefield Publishers 2014; US$ 82.99
The Manual of Museum Exhibitions is a comprehensive, practical guide to the entire process of planning, designing, producing, and evaluating exhibitions for museums of all kinds. The second edition explores the exhibition development process in greater detail, providing the technical and practical methodologies museum professionals need today.... more...
Wilde Museentranscript 2014; US$ 35.68
In den letzten Jahrzehnten sind im Zuge des Museumsbooms auch zahlreiche von Amateuren betriebene Museen entstanden. Was aber motiviert sie dazu? Was ist so attraktiv am Sammeln und Ausstellen? Inspiriert von Claude L�vi-Strauss' Theorie des �wilden Denkens� hat Angela Jannelli eine Feldforschung in drei Amateurmuseen durchgef�hrt und dort erstmalig... more...
Effective Exhibit Interpretation and DesignAltaMira Press 2013; US$ 42.99
Effective Exhibit Interpretation and Design examines the impact of an integrated approach to exhibit design and development on the effective creation and support of live interpretation of exhibit messages and institutional mission. Bridal argues that the interpreters who bring these exhibitions, an institution?s mission, collections, and stories... more...
Museums and Silent Objects: Designing Effective ExhibitionsAshgate Publishing Ltd 2013; US$ 149.95
In a society where split-second decisions about the value of things are grounded on how they look, museum visitors are often drawn to visually striking or iconic objects. This book investigates the question of the treatment of items on display in museums which are less conspicuous but potentially just as important as the striking objects, arguing... more...
A Practical Guide to Costume MountingTaylor and Francis 2013; US$ 94.00
The effective preparation of garments for display is essential for exhibitions of contemporary and historical dress. Costumes not only need to be visually appealing but also fully supported and historically accurate. This book provides a comprehensive guide to mounting costumes from the eighteenth century to the present day. It includes methods for... more...
Ausstellungen entwerfen / Designing ExhibitionsDe Gruyter 2012; US$ 39.95
Drawing on examples from the authors? own experience as exhibition designers, this book examines every phase of exhibition creation. Topics include concept and design, presentation and staging, communicative forms and media, text and graphics, typography and layout, and the use of lighting. more...
Exhibiting CulturesSmithsonian 2012; US$ 24.95
Debating the practices of museums, galleries, and festivals, Exhibiting Cultures probes the often politically charged relationships among aesthetics, contexts, and implicit assumptions that govern how art and artifacts are displayed and understood. The contributors?museum directors, curators, and scholars in art history, folklore, history, and anthropology?represent... more...
The Thing about MuseumsTaylor and Francis 2011; US$ 54.95
The Things about Museums constitutes a unique, highly diverse collection of essays unprecedented in existing books in either museum and heritage studies or material culture studies. Taking varied perspectives and presenting a range of case studies, the chapters all address objects in the context of museums, galleries and/or the heritage sector more... more...


text:
Carpool Crawfordville 32327,US → Tallahassee (FL) 32317-,US Rideshare Carpool Crawfordville → Tallahassee Find your perfect carpool to work or for any trip. FREE. Start a website for your group!
Tallahassee → Tallahassee sagesure insurance management
♂ Male Smoker
carpool vanpool telecommute take mass transportation
♂ Male Smoker
carpool vanpool telecommute take mass transportation
Tallahassee Levy Park → TallahasseeMoving closer to town Nov Looking for biking partners: Would like a relaxed bike ride to work through Oakland Cemetery, Frenchtown to Madison Street in the mornings: Thinking there would be greater visibility with more than one cyclist. Share a ride to work- I drive a small car but occasionally drive a two passenger small truck
Driver or passenger
♀ Female Non-Smoker
carpool walk cycle take mass transportation
♀ Female Non-Smoker
carpool walk cycle take mass transportation
150,476 Cars off the road
767,734 mt CO2
86,513,987 Gallons
327,491,066 Liters
1,585,114,962 Miles
2,550,995,255 Kilometers
Recent trip destinationssagesure insurance management Tallahassee
Scan trips in your regionGlobal Carpool now! Carpool everywhere! United States Florida Search
Recent trip originsLevy Park Tallahassee


text:
Content count69
Last visited
Community Reputation1 Neutral
About Aitchmack
GDT: Devils vs Penguins, 7PM
Aitchmack replied to Zubie#8's topic in HellMan, I'm loving this team. Don't think Cammalleri gets enough credit for his playmaking or his willingness to defend & block shots.
Once again... Paris is under heavy attack
Aitchmack replied to moustic's topic in Off-TopicMoustic, my thoughts are with you and all Parisians tonight. I'm in the UK and an watching it the horror unfold on T.V. Senseless, pointless terrorism. Stay safe friend.
GDT Canucks at Devils 5pm
Aitchmack replied to Satans Hockey's topic in HellCan someone tell me what was so wrong with Larssons hit? There's no way he was targeting the guys head. It was shoulder to shoulder petty much.
GDT 11/3 Devs msg+2 @ Isles msg+ 7pm
Aitchmack replied to lazer's topic in HellWhy is there a car next to the rink? Bizarre! Let's go Devils!
GDT Halloween Isles msg+ @ Devs msg @1pm
Aitchmack replied to lazer's topic in HellAfter watching the half hearted performances of the last couple of seasons I really wasn't expecting much from this season. But I have to say I'm really enjoying it. Hynes really has to take a lot of credit for organising this team so well & motivating them. Great win today even though the performance wasn't as good as it has been previously. LGD.
GDT: Columbus Blue Jackets Vs New Jersey Devils
Aitchmack replied to Devils01's topic in HellEvening. Let's hope they can cut out the penalties tonight. Get a lead early against a team that's used to losing could be big psychologically. LGD
It's not going to be who can create the most chances wins this game, it'll be who manages to make the least mistakes.
FFS Gelinas what we're you thinking?
I thought Zajac had missed that at first. Way to go Devils!
Who wants to win in regulation? Doing it in OT is so much more exciting. Nicely done by Lars. He's been playing well.
Wow. Didn't see that coming. A lead for the first time this season. Great finish by Zajac.
Let's hope the team can maintain their effort/consistency of the last couple of games. Bit worried about Domi/Duclair. LGD.
That was some performance by Greene in OT. That clearance on the crease was amazing.
Woohoo! First win! Stempniak played well all game (apart from another silly penalty). Nicely set up by Rico.
At least Hynes has the intermission to tell them what to do on the PP. The first one was awful. I know Larsson screwed up for the goal but he's looked much more confident on the puck this season & stronger holding players off.


text:
Poison Cosplay by shprotonWatch
©2013-2016 shproton
Sometimes I wonder what goes through a girl who knows what goes through a guy's mind when she does things like this...
They know what is the men's biggest weakness...
Dang it...can't focus...
They know what is the men's biggest weakness...
Dang it...can't focus...
if only tht top got wet either way epic poison cosplay, best i have seen.
thats it, take it all, baby yum ill bet even the photographer, she was hot for you by the end of the session
Well....that's incredibly sexy....
love it that water dripping down perfectly captured
Nice !
It's a traaaaaaaaaaaaap
Beautiful and sexy shot! Although now I am thirsty.
*cough* -clears throat- "Water please, oh nope all gone... ya kinda spilled it"
Better to dink often to prevent dehydration...
this is... damn hot!!
Wow, this photo is beyond sexy! Your face, the hair, the amazing cleavage.... damn! Well done!!
Christ. What a great composition. Love the lighting and pose too.<3
awesome Model...great Pose and Light
Wow, stunning photograph!
Ever consider doing a Tifa Lockhart Cosplay from FF VII? You'd be great I think.
I never thought about it before, but... Why not? Anyway, this is unlikely to happen this year, we already have planned a lot of characters ;(
Absolutely superb.
very sexy!
I'll tap that trap!
Suddenly I envy WATER!


text:
Are you Ryan Jankord?Claim your profile
Publications (23)89.27 Total impact
- [Show abstract] [Hide abstract] ABSTRACT: Investigations into the use of transcranial direct current stimulation (tDCS) in relieving symptoms of neurological disorders and enhancing cognitive or motor performance have exhibited promising results. However, the mechanisms by which tDCS effects brain function remain under scrutiny. We have demonstrated that in vivo tDCS in rats produced a lasting effect on hippocampal synaptic plasticity, as measured using extracellular recordings. Ex vivo preparations of hippocampal slices from rats that have been subjected to tDCS of 0.10 or 0.25 mA for 30 min followed by 30 min of recovery time displayed a robust twofold enhancement in long-term potentiation (LTP) induction accompanied by a 30% increase in paired-pulse facilitation (PPF). The magnitude of the LTP effect was greater with 0.25 mA compared with 0.10 mA stimulations, suggesting a dose-dependent relationship between tDCS intensity and its effect on synaptic plasticity. To test the persistence of these observed effects, animals were stimulated in vivo for 30 min at 0.25 mA and then allowed to return to theirhomecage for 24 h. Observation of the enhanced LTP induction, but not the enhanced PPF, continued 24 h after completion of 0.25 mA of tDCS. Addition of the NMDA blocker AP-5 abolished LTP in both control and stimulated rats but maintained the PPF enhancement in stimulated rats. The observation of enhanced LTP and PPF after tDCS demonstrates that non-invasive electrical stimulation is capable of modifying synaptic plasticity.
- [Show abstract] [Hide abstract] ABSTRACT: The effects of chronic stress on learning are highly variable across individuals. This variability stems from gene-environment interactions. However, the mechanisms by which stress affects genetic predictors of learning are unclear. Thus, we aim to determine whether the genetic pathways that predict spatial memory performance are altered by previous exposure to chronic stress. Sixty-two BXD recombinant inbred strains of mice, as well as parent strains C57BL/6J and DBA/2J, were randomly assigned as behavioral control or to a chronic variable stress paradigm and then underwent behavioral testing to assess spatial memory and learning performance using the Morris water maze. Quantitative trait loci (QTL) mapping was completed for average escape latency times for both control and stress animals. Loci on chromosomes 5 and 10 were found in both control and stress environmental populations; eight additional loci were found to be unique to either the control or stress environment. In sum, results indicate that certain genetic loci predict spatial memory performance regardless of prior stress exposure, while exposure to stress also reveals unique genetic predictors of training during the memory task. Thus, we find that genetic predictors contributing to spatial learning and memory are susceptible to the presence of chronic stress. Copyright © 2015. Published by Elsevier Inc.
Article: Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice[Show abstract] [Hide abstract] ABSTRACT: Glucocorticoids act rapidly at the paraventricular nucleus (PVN) to inhibit stress-excitatory neurons and limit excessive glucocorticoid secretion. The signaling mechanism underlying rapid feedback inhibition remains to be determined The present study was designed to test the hypothesis that the canonical glucocorticoid receptors (GR) is required for appropriate hypothalamic-pituitary-adrenal (HPA) axis regulation. Local PVN GR knockdown was achieved by breeding homozygous floxed GR mice with Sim1-cre recombinase transgenic mice. This genetic approach created mice with a knockdown of GR primarily confined to hypothalamic cell groups including the PVN, sparing GR expression in other HPA axis limbic regulatory regions and the pituitary. There were no differences in circadian nadir and peak corticosterone concentrations between male PVN GR KD mice and male littermate controls. However, reduction of PVN GR increased ACTH and corticosterone responses to acute, but not chronic stress, indicating that PVN GR is critical for limiting neuroendocrine responses to acute stress in males. Loss of PVN GR induced an opposite neuroendocrine phenotype in females, characterized by increased circadian nadir corticosterone levels and suppressed ACTH responses to acute restraint stress, without a concomitant change in corticosterone responses under acute or chronic stress conditions. PVN GR deletion had no effect on depression-like behavior in either sex in the forced swim test. Overall, these findings reveal pronounced sex differences in the PVN GR dependence of acute stress feedback regulation of HPA axis function. In addition, these data further indicate that glucocorticoid control of HPA axis responses following chronic stress operates via a PVN-independent mechanism.
Article: Unique genetic loci identified for emotional behavior in control and chronic stress conditions[Show abstract] [Hide abstract] ABSTRACT: An individual's genetic background affects their emotional behavior and response to stress. Although studies have been conducted to identify genetic predictors for emotional behavior or stress response, it remains unknown how prior stress history alters the interaction between an individual's genome and their emotional behavior. Therefore, the purpose of this study is to identify chromosomal regions that affect emotional behavior and are sensitive to stress exposure. We utilized the BXD behavioral genetics mouse model to identify chromosomal regions that predict fear learning and emotional behavior following exposure to a control or chronic stress environment. 62 BXD recombinant inbred strains and C57BL/6 and DBA/2 parental strains underwent behavioral testing including a classical fear conditioning paradigm and the elevated plus maze. Distinct quantitative trait loci (QTLs) were identified for emotional learning, anxiety and locomotion in control and chronic stress populations. Candidate genes, including those with already known functions in learning and stress were found to reside within the identified QTLs. Our data suggest that chronic stress history reveals novel genetic predictors of emotional behavior.
Article: Identification of chronic stress-activated regions reveals a potential recruited circuit in rat brain[Show abstract] [Hide abstract] ABSTRACT: Chronic stress induces presynaptic and postsynaptic modifications in the paraventricular nucleus of the hypothalamus that are consistent with enhanced excitatory hypothalamo-pituitary-adrenocortical (HPA) axis drive. The brain regions mediating these molecular modifications are not known. We hypothesized that chronic variable stress (CVS) tonically activates stress-excitatory regions that interact with the paraventricular nucleus of the hypothalamus, culminating in stress facilitation. In order to identify chronically activated brain regions, ΔFosB, a documented marker of tonic neuronal activation, was assessed in known stress regulatory limbic and brainstem sites. Four experimental groups were included: CVS, repeated restraint (RR) (control for HPA habituation), animals weight-matched (WM) to CVS animals (control for changes in circulating metabolic factors due to reduced weight gain), and non-handled controls. CVS, (but not RR or WM) induced adrenal hypertrophy, indicating that sustained HPA axis drive only occurred in the CVS group. CVS (but not RR or WM) selectively increased the number of FosB/ΔFosB nuclei in the nucleus of the solitary tract, posterior hypothalamic nucleus, and both the infralimbic and prelimbic divisions of the medial prefrontal cortex, indicating an involvement of these regions in chronic drive of the HPA axis. Increases in FosB/ΔFosB-immunoreactive cells were observed following both RR and CVS in the other regions (e.g. the dorsomedial hypothalamus), suggesting activation by both habituating and non-habituating stress conditions. The data suggest that unpredictable stress uniquely activates interconnected cortical, hypothalamic, and brainstem nuclei, potentially revealing the existence of a recruited circuitry mediating chronic drive of brain stress effector systems.
Article: Opposing effects of chronic stress and weight restriction on cardiovascular, neuroendocrine and metabolic function[Show abstract] [Hide abstract] ABSTRACT: Chronic stress is associated with dysregulation of energy homeostasis, but the link between the two is largely unknown. For most rodents, periods of chronic stress reduce weight gain. We hypothesized that these reductions in weight are an additional homeostatic challenge, contributing to the chronic stress syndrome. Experiment #1 examined cardiovascular responsivity following exposure to prolonged intermittent stress. We used radio-telemetry to monitor mean arterial pressure and heart rate in freely moving, conscious rats. Three groups of animals were tested: chronic variable stress (CVS), weight-matched (WM), and controls. Using this design, we can distinguish between effects due to stress and effects due to the changing body weight. WM, but not CVS, markedly reduced basal heart rate. Although an acute stress challenge elicited similar peak heart rate, WM expedited the recovery to baseline heart rate. The data suggest that CVS prevents the weight-induced attenuation of cardiovascular stress reactivity. Experiment #2 investigated hypothalamic-pituitary-adrenal axis and metabolic hormone reactivity to novel psychogenic stress. WM increased corticosterone area under the curve. CVS blunted plasma glucose, leptin, and insulin levels in response to restraint. Experiment #3 tested the effects of WM and CVS on PVN oxytocin and corticotrophin-releasing hormone mRNA expression. CVS increased, while WM reduced PVN CRH mRNA expression, whereas both CVS and WM reduced dorsal parvocellular PVN oxytocin mRNA. Overall, the data suggest that weight loss is unlikely to account for the deleterious effects of chronic stress on the organism, but in fact produces beneficial effects that are effectively absent or indeed, reversed in the face of chronic stress exposure.
- [Show abstract] [Hide abstract] ABSTRACT: Adolescent development is proposed to represent a time of increased susceptibility to stress. During adolescence, the brain demonstrates a high level of plasticity and can be positively or negatively affected by the environment. This study tests the hypothesis that adolescent development is a stage of enhanced vulnerability to chronic stress. Male Sprague-Dawley rats were exposed to our 14-d chronic variable stress (CVS) paradigm at three developmental stages: 1) early adolescence (35 d; age at initiation of CVS); 2) late adolescence (50 d); or 3) adulthood (80 d). We examined the effects of CVS on the following: 1) depression-like behavior; 2) somatic indices; 3) hypothalamic-pituitary-adrenal (HPA) axis activity; and 4) neuropeptide expression in the hypothalamus. Results show, regardless of age, CVS exposure: 1) decreased body weight; 2) increased adrenal size; 3) decreased fat weight; and 4) increased HPA response to stress. The somatic effects of CVS were exaggerated in late adolescent animals, and late adolescent animals were the only group where CVS decreased oxytocin expression and increased basal corticosterone. In response to CVS, adult animals increased immobility during the forced-swim test while early and late adolescent animals were resistant to the effects of chronic stress on depression-like behavior. Results show that adolescent animals were protected from the effect of chronic stress on depression-like behavior while late adolescent animals were more susceptible to the somatic, HPA axis, and neuropeptide effects of chronic stress. Thus, adolescent development is a unique window of vulnerabilities and protections to the effects of chronic stress.
- [Show abstract] [Hide abstract] ABSTRACT: The nucleus of the solitary tract (NTS) is a critical integrative site for coordination of autonomic and endocrine stress responses. Stress-excitatory signals from the NTS are communicated by both catecholaminergic [norepinephrine (NE), epinephrine (E)] and noncatecholaminergic [e.g., glucagon-like peptide-1 (GLP-1)] neurons. Recent studies suggest that outputs of the NE/E and GLP-1 neurons of the NTS are selectively engaged during acute stress. This study was designed to test mechanisms of chronic stress integration in the paraventricular nucleus, focusing on the role of glucocorticoids. Our data indicate that chronic variable stress (CVS) causes downregulation of preproglucagon (GLP-1 precursor) mRNA in the NTS and reduction of GLP-1 innervation to the paraventricular nucleus of the hypothalamus. Glucocorticoids were necessary for preproglucagon (PPG) reduction in CVS animals and were sufficient to lower PPG mRNA in otherwise unstressed animals. The data are consistent with a glucocorticoid-mediated withdrawal of GLP-1 in key stress circuits. In contrast, expression of tyrosine hydroxylase mRNA, the rate-limiting enzyme in catecholamine synthesis, was increased by stress in a glucocorticoid-independent manner. These suggest differential roles of ascending catecholamine and GLP-1 systems in chronic stress, with withdrawal of GLP-1 involved in stress adaptation and enhanced NE/E capacity responsible for facilitation of responses to novel stress experiences.
- [Show abstract] [Hide abstract] ABSTRACT: Stress preferentially increases the consumption of high fat foods in women, suggesting the interaction of these two factors may disproportionately predispose women toward excess weight gain. In the present study, female rats were exposed to a chronic high fat or chow diet and were exposed to 4weeks of chronic variable stress (CVS) or served as home cage controls. Control females exposed to a high fat diet displayed many symptoms of the metabolic syndrome including increased body weight gain, total and visceral adiposity and insulin and leptin concentrations relative to all groups. However, CVS-high fat, CVS chow and control chow groups had similar body weight gain and caloric efficiency. This finding suggests that CVS increases energy expenditure much more in females exposed to a high fat diet relative to those fed a standard chow diet. The CVS-high fat group had increased adiposity and increased circulating leptin and insulin concentrations, despite the fact that their body weight did not differ from the controls. These results underscore the importance of assessing the degree of adiposity, rather than body weight alone, as an index of overall metabolic health. Overall, the data indicate that in female rats, chronic stress prevents high fat diet related increases in body weight, but does not prevent high fat diet induced increases in adiposity when compared to chow-fed females.
Article: Lack of vasopressin does not prevent the behavioral and endocrine changes induced by chronic unpredictable stress[Show abstract] [Hide abstract] ABSTRACT: Vasopressin (VP) plays an important role in hypothalamo-pituitary-adrenal (HPA) axis regulation and in stress-related disorders. Our previous studies confirmed the role of VP in acute situations, where VP-deficient Brattleboro rats had less depression-like behaviour compared to animals that express VP. In this study, we test the hypothesis that VP-deficient rats are more resistant to the development of chronic HPA axis hyperactivity and depression-like symptoms after chronic unpredictable stress (CUS). Male VP-deficient Brattleboro rats were compared to their heterozygous littermates (controls). CUS consisted of different mild stimuli for 5 weeks. Elevated plus maze and forced swim test were used for behavioural characterization, while organs and blood for HPA axis parameters were collected at the end of the experiment. In controls, CUS resulted in the development of chronic stress state characterized by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary). Floating time in the forced swim test was enhanced together with reduced open arm entries on elevated plus maze and a reduction in daily food intake. Unexpectedly, the lack of VP did not alter the effect of CUS on the somatic and behavioural measures, but only prevented CUS-induced corticosterone changes. In conclusion, lifelong VP-deficiency has a positive effect on corticosterone elevation following CUS but does not affect the behavioural consequences of CUS. It is likely that the interplay of several related factors, rather than an alteration in a single neuropeptide, modulates behaviour and disease pathogenesis.
- [Show abstract] [Hide abstract] ABSTRACT: An emerging literature attests to the ability of psychological stress to alter the inflammatory cytokine environment of the body. While the ability of stress to cause cytokine release is well established, the neural pathways involved in this control have yet to be identified. This study tests the hypothesis that IL-6 neurons of the hypothalamo-neurohypophyseal system (HNS), a neural pathway proposed to secrete IL-6 into the circulation, are activated in response to psychological stress. Colocalization studies confirm robust expression of IL-6 in cell bodies and fibers of vasopressin (but not oxytocin) neurons of the paraventricular (PVN) and supraoptic nucleus (SON) of the rat hypothalamus. In response to restraint, there was a greater increase in c-Fos expression in SON IL-6-positive (IL-6+) neurons. In addition, both psychogenic (restraint) or systemic stress (hypoxia) lead to phosphorylated ERK induction only in IL-6+ magnocellular neurons, indicating selective activation of the MAPK signaling pathway in the IL-6 subset of magnocellular neurons. Finally, restraint upregulated IL-6 mRNA expression in both the PVN and SON, which was accompanied by a four-fold increase in circulating IL-6. The data indicate that noninflammatory stressors selectively activate IL-6 magnocellular neurons, upregulate IL-6 gene expression in the PVN and SON, and increase plasma IL-6. In summary, results show that IL-6 neurons of the HNS are a recruited component of the response to psychological stress.
Article: The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. J Endocrinol 202, 263-278[Show abstract] [Hide abstract] ABSTRACT: Adaptation to a constantly changing environment is fundamental to every living organism. The hypothalamic-pituitary-adrenocortical (HPA) axis is a key component of the adaptation process. The present study tests the hypothesis that vasopressin (AVP) is required for the HPA response to acute stimuli. To accomplish this, naturally AVP-deficient Brattleboro rats were exposed to a wide range of stimuli and their HPA response was compared with heterozygous littermates. The circadian rhythmicity of plasma ACTH and corticosterone was not different between the two genotypes. The ACTH and corticosterone response to volume load, restraint or aggressive attack were decreased in AVP-deficient rats. The stress-induced increase in ACTH, but not corticosterone, was significantly impaired in AVP-deficient animals after novelty, elevated plus-maze, forced swim, hypoglycaemia, ulcerogenic cold immobilisation, lipopolysaccharide, hypertonic saline and egg white injection. The HPA response to social avoidance, ether inhalation and footshock was not different between the genotypes. In vitro, the hypophysis of AVP-deficient animals showed a reduction in stimulated ACTH production and their adrenal glands were hyporeactive to ACTH. A dissociation between the ACTH and corticosterone response was observed in several experiments and could not be explained by an earlier ACTH peak or enhanced adrenal sensitivity, suggesting the existence of paraadenohypophyseal neuroendocrine regulators. Loss of AVP affected the HPA response to a wide variety of stressors. Interestingly, the contribution of AVP to the HPA response was not specific for, nor limited to, a known stressor category. Thus, there is a context-specific requirement for AVP in stress-induced activation of the HPA axis.
- [Show abstract] [Hide abstract] ABSTRACT: Exercise can activate the hypothalamo-pituitary-adrenocortical (HPA) axis, and regular exercise training can impact how the HPA axis responds to stress. The mechanism by which acute exercise induces HPA activity is unclear. Therefore, the purpose of this study was to test the hypothesis that nitric oxide modulates the neuroendocrine component of the HPA axis during exercise. Female Yucatan miniature swine were treated with N-nitro-l-arginine methyl ester (l-NAME) to test the effect of chronic nitric oxide synthase (NOS) inhibition on the ACTH response to exercise. In addition, we tested the effect of NOS inhibition on blood flow to tissues of the HPA axis and report the effects of handling and treadmill exercise on the plasma concentrations of ACTH and cortisol. Chronic NOS inhibition decreased plasma NO(x) levels by 44%, increased mean arterial blood pressure by 46%, and increased expression of neuronal NOS in carotid arteries. Vascular conductance was decreased in the frontal cortex, the hypothalamus, and the adrenal gland. Chronic NOS inhibition exaggerated the ACTH response to exercise. In contrast, chronic NOS inhibition decreased the ACTH response to restraint, suggesting that the role of NO in modulating HPA activity is stressor dependent. These results demonstrate that NOS activity modulates the response of the neuroendocrine component of the HPA axis during exercise stress.
Article: Limbic Regulation of Hypothalamo-Pituitary-Adrenocortical Function during Acute and Chronic Stress[Show abstract] [Hide abstract] ABSTRACT: The hypothalamo-pituitary-adrenocortical (HPA) axis is responsible for initiation of glucocorticoid stress responses in all vertebrate animals. Activation of the axis is regulated by diverse afferent input to the hypothalamic paraventricular nucleus (PVN). This review discusses brain mechanisms subserving generation and inhibition of stress responses focusing on the contribution of the limbic system and highlighting recent conceptual advances regarding organization of stress response pathways in the brain. First, control of HPA axis responses to psychogenic stimuli is exerted by a complex neurocircuitry that involves oligosynaptic networks between limbic forebrain structures and the PVN. Second, individual stress-modulatory structures can have a heterogeneous impact on HPA axis responses, based on anatomical micro-organization and/or stimulus properties. Finally, HPA axis hyperactivity pursuant to chronic stress involves a substantial functional and perhaps anatomical reorganization of central stress-integrative circuits. Overall, the data suggest that individual brain regions do not merely function as monolithic activators or inhibitors of the HPA axis and that network approaches need be taken to fully understand the nature of the neuroendocrine stress response.
- [Show abstract] [Hide abstract] ABSTRACT: Eating and physical activity behaviors influence neuroendocrine output. The purpose of this study was to test, in an animal model of diet-induced cardiovascular disease, the effects of high-fat feeding and exercise training on hypothalamo-pituitary-adrenocortical (HPA) axis activity. We hypothesized that a high-fat diet would increase circulating free fatty acids (FFAs) and decrease the adrenocorticotropic hormone (ACTH) and cortisol response to an acute stressor. We also hypothesized that exercise training would reverse the high-fat diet-induced changes in FFAs and thereby restore the ACTH and cortisol response. Pigs were placed in 1 of 4 groups (normal diet, sedentary; normal diet, exercise training; high-fat diet, sedentary; high-fat diet, exercise training; n = 8/group). Animals were placed on their respective dietary and activity treatments for 16-20 weeks. After completion of the treatments animals were anesthetized and underwent surgical intubation. Blood samples were collected after surgery and the ACTH and cortisol response to surgery was determined and the circulating concentrations of FFAs, glucose, cholesterol, insulin, and IGF-1 were measured. Consistent with our hypothesis, high-fat feeding increased FFAs by 200% and decreased the ACTH stress response by 40%. In exercise-trained animals, the high-fat diet also increased FFA; however, the increase in FFA in exercise-trained pigs was accompanied by a 60% increase in the ACTH response. The divergent effect of high-fat feeding on ACTH response was not expected, as exercise training alone had no effect on the ACTH response. Results demonstrate a significant interaction between diet and exercise and their effect on the ACTH response. The divergent effects of high-fat diet could not be explained by changes in weight gain, blood glucose, insulin, or IGF-1, as these were altered by high-fat feeding, but unaffected by exercise training. Thus, the increase in FFA with high-fat feeding may explain the blunted ACTH response to an acute stressor in sedentary animals, but cannot explain the exaggerated response in exercise trained animals.
- [Show abstract] [Hide abstract] ABSTRACT: Proper integration and execution of the physiological stress response is essential for maintaining homoeostasis. Stress responses are controlled in large part by the paraventricular nucleus (PVN) of the hypothalamus, which contains three functionally distinct neural populations that modulate multiple stress effectors: (1) hypophysiotrophic PVN neurons that directly control the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis; (2) magnocellular neurons and their secreted neurohypophysial peptides; and (3) brainstem and spinal cord projecting neurons that regulate autonomic function. Evidence for activation of PVN neurons during acute stress exposure demonstrates extensive involvement of all three effector systems. In addition, all PVN regions appear to participate in chronic stress responses. Within the hypophysiotrophic neurons, chronic stress leads to enhanced expression of secreted products, reduced expression of glucocorticoid receptor and GABA receptor subunits and enhanced glutamate receptor expression. In addition, there is evidence for chronic stress-induced morphological plasticity in these neurons, with chronic drive causing changes in cell size and altered GABAergic and glutamatergic innervation. The response of the magnocellular system varies with different chronic exposure paradigms, with changes in neurohypophysial peptide gene expression, peptide secretion and morphology seen primarily after intense stress exposure. The preautonomic cell groups are less well studied, but are likely to be associated with chronic stress-induced changes in cardiovascular function. Overall, the PVN is uniquely situated to coordinate responses of multiple stress effector systems in the face of prolonged stimulation, and likely plays a role in both adaptation and pathology associated with chronic stress.
- [Show abstract] [Hide abstract] ABSTRACT: Inflammation contributes to disease development, and the neuroimmunoendocrine interface is a potential site of action for inflammatory products like IL-6 to affect health. Although plasma IL-6 can stimulate the activity of the hypothalamo-pituitary-adrenocortical (HPA) axis, the precise role, if any, for IL-6 in the HPA response to nonimmunological stressors is unclear. The purpose of this study was to test the hypothesis that IL-6 in the stalk median eminence (SME) can be directly involved in stimulating ACTH secretion in response to acute stress in female swine. This study was undertaken as a result of finding IL-6 localized to the external zone of the SME next to the hypophyseal portal vessels. Results indicate that content of IL-6 in the SME decreases in response to acute stress along with an increase in nuclear phosphorylated signal transducer and activator of transcription-3 (pSTAT-3) in pituitary corticotrophs and a simultaneous increase in plasma concentrations of IL-6 and ACTH. Furthermore, we show that females concomitantly display greater SME content of IL-6 and greater HPA responsiveness to stress, thereby suggesting that IL-6 release from the SME is an integral factor contributing to enhanced stress responsiveness in females. Our results provide evidence for a direct link between IL-6 and ACTH release and reveal a sex difference in this relationship.
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University of CincinnatiCincinnati, Ohio, United States
University of Missouri
Columbia, Missouri, United States
- Department of Biomedical Sciences


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My new laptop toy.......not as easy as it sounds.....
Sunday, February 03, 2013
I am playing with my new laptop.....it is very different than the old one.....the start screen looks a lot like my smart phone screen......I am having a little problem with doing what I want to do.......I keep putting myself back to the start screen......I think I have a handle on it somewhat, but then it jumps back to the start screen.....LOL
After Hubby's work shift today, we went to the fitness center and did some water walking.....the resistance is still cranked up like it was the other day....Hubby and DD noticed it right away........I guess I did not tell them it was cranked up, just anyone who read my blog......
They both agreed it was a bigger challenge.....guess they thought they were wimps like I did the other day......We went for supper after the workout and I ate a great big salad before anything else, so I curbed my hunger a little that way........still had a little off the buffet, but not nearly what I would have taken several months ago....I even took the skin off of my broasted chicken thigh....yes I took dark meat, but the breast was way too much for me to eat after my salad. I skipped the soup, as it is usually very salty
I did have a little soft serve with a small dessert pizza slice.........I should have skipped the dessert pizza too, but it was peach, a weakness of mine......I will pretend there is some good nutrition in the peach part, but I doubt it.
Getting back to the new laptop.....I very much like the fact that it has a number keypad, as most older ones do not....however, the keyboard is shifted a little to the left, so I keep putting my fingers in the wrong spot...
I know I was going to weigh in at my doctor's appointment on Wednesday, but I did a sneak peek at the fitness center and I liked the numbers.....now to see if they hold out for me.
Well it looks as though the Super Bowl is turning out closer than it first appeared, before the lights went out in New Orleans.......isn't there a song like that? I know it is Georgia not New Orleans, but so what.......
One of the things I have to do yet is to figure out how to change the clock on the laptop and how to turn it off.......could not figure that out earlier today.....
That may be rocket science....who knows.
I guess I will sign off for now and see if I can solve the world of my laptop's problems.....Good night, Lynel
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Happy to see you are enjoying your new laptop! I can't wait to get mine....I hope it comes before this one crashes. I walked away from it yesterday only to return to a screen that looked incredibly weird....everything was all jumbled together, couldn't read anything nor make out what was supposed to be on the screen to begin with. I shut it off and rebooted it and it has been okay since....just a little slow. I guess it's becoming a
too LOL Oh well, at least it's in good company :)
1210 days ago
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Malcolm and Lily try to start their lives as they watch Malcolm's grandparents' fall apart.
149 backers pledged $21,314 to help bring this project to life.
Fully cast! Shooting starts tomorrow!
Hi Everyone!
We have some exciting announcements to make about Lake City.
First of all, the film is now fully cast. Dominic Chianese and Joanna Merlin will be joining Jonathan... Read more
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When we decided to set our Kickstarter goal at $20,000, we thought of it as a stretch. Only 40% of film-related Kickstarters reach their funding goals, and the... Read more
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Women's Tennis Photos
Action photos of our women's tennis! www.mchenry.edu/athletics/wtennis/roster.aspPosted by McHenry County College on Tuesday, September 29, 2015
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I'm so sorry your mom is feeling so badly. I agree with Lainy. Seems like this doctor has already given up. My mom had two internal stents and one external stent via ERCP. Lainy is right, these stents are placed in to relieve the blockage. Once inserted in the blocked area, flow should resume. The problems my mom had with the stents were the numerous infections. These stents, especially the small, plastic stents block very easily and result in infections. My mom also had the jaundice, the clay colored stools, all due to the blocked stents/infections.
I totally agree with Lainy that if you can, get a second opinion.
1 Mon, 03 Nov 2014 22:11:49
Re: ERCP recovery (16 replies, posted in General Discussion)
2 Fri, 13 Jun 2014 21:34:24
Re: Feeling sad (14 replies, posted in Grief Management)
It's been 13 months exactly since my mom passed away. I still have those days... I miss her everyday.
One of the things I miss the most is saying the word MOM. I never knew how precious the word MOM is until my mom was gone and I had no one on earth to call Mom. I know she is no longer suffering, no more pain, but it doesn't take the pain of missing her.
3 Thu, 20 Mar 2014 20:04:32
Re: Another Angel (5 replies, posted in In Remembrance)
I've been following his mother's posts on FB. I cannot imagine. It is horrible losing my mom last year, but losing a son, so young. I am at a loss for words.
4 Sat, 08 Feb 2014 21:44:18
Re: Good blood work (9 replies, posted in Good News / What's Working)
So great to hear things are well!
5 Mon, 13 Jan 2014 23:06:24
Re: 43 yr old male diagnosed last month (8 replies, posted in Introductions!)
Have you tried applying for medicaid? I know it's not a fast process, but just as Kris v recommended, speak to the social worker and they may be able to give you information. Let them know of your situation and hopefully, they can assist you in the right direction.
6 Sun, 12 Jan 2014 20:30:38
Re: Cholangiocarcinoma (21 replies, posted in Supportive, Palliative & Hospice Care)
Kris V.
I couldn't have said it better myself. I also am a home care nurse and agree that home care services are not utilized enough. I think if doctors were better educated on the variety of services available for patients at home after discharge from hospitals, it would help patients and families...
Also, if anyone is a veteran, I do believe the that government will pay for private duty assistance in the home that medicare and private insurances do not cover.
Also, speak to a social worker at the hospital or if you already have home care services at home, most home care agencies have social workers available, they may be able to assist you finding volunteer organizations may offer respite care.
7 Sun, 12 Jan 2014 18:54:56
Topic: Beautiful Poem (9 replies, posted in Grief Management)
My dad read the book " Proof of Heaven" and in it was a poem by David Romano "When Tomorrow Starts Without Me"...
When tomorrow starts without me,
And I'm not there to see,
If the sun should rise and find your eyes,
All filled with tears for me,
I wish so much you wouldn't cry
They way you did today,
While thinking of the many things,
We didn't get to say.
I know how much you love me,
As much as I love you
And each time you think of me,
I know you'll miss me too
But when tomorrow starts without me,
Please try to understand,
That an angel came and called my name,
And took me by the hand,
And said my place was ready,
In heaven far above
And that I'd have to leave behind
All those I dearly love.
But as I turned to walk away,
A tear fell from my eye
For all my life, I'd always thought,
I didn't want to die.
I had so much to live for,
So much left yet to do.
It seemed almost impossible
That I was leaving you.
I thought of all the yesterdays,
The good ones and the bad,
The thought of all the love we shared,
And all the fun we had.
If i could relive yesterday,
Just even for a while,
I'd say good bye and kiss you
and maybe see you smile
But then I fully realized
That this could never be,
For emptiness and memories,
Would take the place for me.
And when I thought of worldly things
I might miss come tomorrow
I thought of you and when i did
My heart was filled with sorrow
But when I walked through heaven's gates
I felt so much as home
When God looked down and smiled at me,
From His great golden throne,
He said, "this is eternity
And all I've promised you,
Today your life on earth is past
But here it starts anew
I promise no tomorrow
But today will always last
And since each day's the same way
There's no longing for the past
You have been so faithful
So trusting and so true
Though there were times
You did somethings
You knew you shouldn't do
But you have been forgiven
And now at last you're free
So won't you come and take my hand
And share my life with me?
So when tomorrow starts without me
Don't think we're far apart
For every time you think of me
I'm right here in you heart.
8 Fri, 10 Jan 2014 19:10:20
Re: Desperately seeking support (18 replies, posted in Introductions!)
Thank you Laney for your kind words.
9 Fri, 10 Jan 2014 19:08:17
Re: Not an official member yet (20 replies, posted in Introductions!)
My mom was diagnosed with renal call carcinoma approx 12 years ago. Partial nephrectomy took care of that, but unfortunately, she was diagnosed with this 12 years later.
10 Tue, 07 Jan 2014 22:52:43
Re: GEM/CIS, now imrt, then what? (15 replies, posted in General Discussion)
My mom received IMRT and chemotherapy at the same time. Chemo: gemzar only. IMRT 28 sessions. Gemzar for 7 months. My mom decided to stop gemzar after 7 months because she was feeling so ill. Initially, she received clear scans(CT and PET scan) after treatments, but then became ill only one month later because of occluded bile ducts. She then required stents. Her tumor was also in the caudate lobe. No surgery due to involvement of portal vein.
Everyone responds differently. Unfortunately, mom initially received great news after treatment was done, but then only one month later, complications started.
11 Tue, 07 Jan 2014 22:45:18
Re: Not an official member yet (20 replies, posted in Introductions!)
Hello fntn,
My mother's needle biopsy came back negative for cancer, but PET scan showed concern. They obtained sample via ERCP which came back at positive for the cancer.
I pray that you will receive good results!
12 Tue, 07 Jan 2014 22:36:09
Re: Desperately seeking support (18 replies, posted in Introductions!)
Hi Michelle,
I am sorry, I took so long to respond to you. First of all, I hope your mom is doing well and she enjoyed her trip!
My mom received radiation and chemotherapy at the same time. She received total of 28 sessions of radiation and chemotherapy once a week for 3 weeks, with one week off for approx 7 months. She was supposed to go 8 months, but she decided she had enough. She tolerated both treatments fairly well for about 2 or 3 months, but then complications one right after another. My poor mom was hospitalized approx 10 times in 18 months, most of the time because of the side effects of the chemotherapy. She went thru hell. She then finally decided she had enough and requested to stop chemotherapy. She got about one month off, then repeat PET scan and CT scan. The oncologist was actually surprised that the liver had improved significantly and that the tumor appeared to have shrunk and was not seen on the scans. He wanted to see her again in 3 months for repeat scans. Then about one month later, I noticed she was jaundiced, called oncologist, they scheduled another CT scan and they found that her bile ducts were occluded. She then was scheduled for ERCP, resulting in 2 plastic stents. They could not insert metal stents because the ducts were too narrow. We could not believe in just one month, how she can go from a clear scan to occluded bile ducts requiring stents. From then on, she became sicker and more hospitalizations due to infections from the stents.
Michelle, the stents, especially plastic (because they are smaller in diameter) are prone to infections. My mom became septic, ICU for almost a week, then it was down hill from then on. I think she was just so sick of being sick and spending majority of the time in the hospital.
As I stated, before she was diagnosed, she was her normal self, active, no pain. She was completely symptom free. But, in her case, it was after she received the treatments that she became so ill.
So, in hind sight, I think, if we could go back in time, I think my mom would have chosen not to receive treatment, given the difficulty she experienced from the radiation and chemotherapy. But, when you are told that you have cancer, you initially want every treatment that is available.
Everyone is different Michelle. My mom just did not do well with the treatments given to her. Especially after the stents were placed. But every person has different experiences. What we learned from our experience is that quality of life is so much more important than quantity. We, especially myself was so not ready to give up and did not want to lose my mom and encouraged her to go through the treatments. But, I saw my mom suffer so much that I wish I can go back in time and knowing what I know now, realize early on that quality of life is more important. Sometimes I feel so guilty, but I know that will not bring my mom back. I miss her everyday, but I know that she is with God and is not suffering anymore.
I hope your mother stays well. Don't be afraid to ask questions. You are your mom's best advocate. But, if you feel like crying, cry. It is a tough journey.
Stay well.
13 Tue, 31 Dec 2013 00:18:28
Re: Desperately seeking support (18 replies, posted in Introductions!)
Hi Michelle,
So very sorry. I must say that your post almost mirrors my mom's journey. At first, I too spent every chance I got on the internet looking for more information about this cancer. But, this site is such a good resource. Wonderful people here with great advice and support.
Unfortunately, my mother passed away over 7 months ago. It was a very difficult journey.
My mother's tumor was centrally located, did not qualify for surgery either. Tumor was about the same size as your mother's. She went thru chemo and radiation, which was hell. When she was diagnosed, she was completely asymptomatic. They actually found the cancer by accident. But probably about one month into the radiation and chemo, she became ill, in pain. Everyone is different. Some tolerate treatment well. But in my mother's case, she did not, but she completed chemo for about 8 months. Then a month after her treatments ended, she became jaundice and required stents. One thing about plastic stents that my mom experienced was that fat that the clot off easily. Watch your mom for fever, chills, nausea, vomitting, abd pain. If symptoms occur, please call MD immediately. My mom actually became septic and required a week in the ICU because of the infection.
It's a tough road, but with you by her side, she will be stronger knowing that you are there for her, by her side, every step.
I often felt so helpless, seeing my mom suffer as she did. This is a terrible disease and I hope they can find more effective treatment.
I hope your mom has fun in Vegas, hopefully bring back from $$$.
14 Tue, 29 Oct 2013 22:41:47
Re: Signs from our Loved ones. (2 replies, posted in Members' Cafe)
I just love your posts. I miss my mom so much. It's been almost 6 months since she passed away and reading your posts.. very comforting. Thank you!
15 Tue, 29 Oct 2013 22:38:48
Re: Reality Stranger than Fiction! (10 replies, posted in Members' Cafe)
wow, that's beautiful
16 Mon, 14 Oct 2013 22:54:53
Re: Options for clogged stents (33 replies, posted in General Discussion)
Hi Peggy,
I am truly sorry that your brother is going through this. My mother had plastic stents. We were given option for metal vs plastic. We were told that the metal stents had decreased chance of clogging only because they were larger in diameter. But the bad thing about the metal stents we were told were that once they placed them, it would be very difficult to remove because of the tissue that grows over them and the stents become imbedded. MD stated that if the metal stents become occluded, they could either try to clean it out or place a plastic stent within the metal stent. But because the occlusions were too narrow, metal stents were too large and was not an option for my mom. So, she ended up with 2 plastic stents and one external/internal stent. The problem is the infection that occurs. I truly believe, it was the multiple infections that followed the stent placements that caused my mother's condition to worsen so quickly. She was admitted with sepsis, spent several days in the ICU and after that her condition quickly worsened. We were told that infection following stent placement was a given. That it would be very difficult to prevent infection. She was on numerous IV antibiotics at home.
The external/internal stent we flushed twice a day, so it decreased the potential for occlusions, but my mom went through much pain with each change.
First, Cipro was the choice for treating the infections, but later stopped working. She was on zosyn and another IV antibiotic at home.
Her stents were changed every 6 to 8 weeks due to blockage and infection.
I hope they can find a solution for your brother.
17 Wed, 04 Sep 2013 20:34:44
Re: high infection (7 replies, posted in Introductions!)
Hi Linamize,
My mother had 2 internal stents and one external stent. She also had numerous infections and was in the ICU one time with sepsis. After the sepsis, that's when her condition worsened. The infections took a toll on her. increased weakness, loss of appetite, muscle mass,etc... I think the infections ultimately lead to her passing rather than the cancer itself. She could not have the metal stents because of the narrow passage. The internal plastic stents continued to clot off due to sludge, resulting in infections. It was awful. She too was on IV ATB at home. We were torn because without the stents, the bili levels, ammonia levels would increase, but with the stents, infection... it's a tough situation.
18 Wed, 04 Sep 2013 20:22:15
Re: Learning to live after Cholangiocarcinoma (10 replies, posted in Introductions!)
My mom left us almost 4 months ago. I miss her everyday. I still have the sweat shirt she wore the last. I have it hanging on my stairwell. I keep it covered so I don't lose her scent. Work keeps me busy. My dad is trying hard to keep it together, but he has his moments. He dreams about her a lot. He says in his latest dreams, my mom keeps leaving and he chases after her. He says she is probably trying to give him a message to let her go and live his life. He is now living by himself and everything in the house reminds him of mom. It is hard, but take it day by day.
19 Sat, 10 Aug 2013 01:54:53
Re: Symptoms from biliary stents ? (4 replies, posted in Adverse Reactions & Side Effects)
Hi Dan,
So very sorry your loved one is going through this. My mom had 2 internal plastic stents and one external/internal stent. She suffered so much from the stents. They caused infections after infections, pain, hospitalizations, sepsis. The external stents are very uncomfortable/painful. The internal stents, unless they are metal, they clot off, get infected and cause so much suffering. Abdominal pain was chronic after the stents were placed.
I truly hope your loved one can get some relieve.
20 Sat, 10 Aug 2013 01:48:16
Re: Visiting the Cemetry (6 replies, posted in Grief Management)
I visit my dear mother's grave at least 2 times a week. ( it is very close to my home) I feel peaceful when I'm there. I know her spirit is not there, but I still go.
21 Fri, 24 May 2013 21:29:31
Re: My Mom (9 replies, posted in In Remembrance)
Thank you Carrie. My heart goes out to everyone diagnosed with this terrible cancer and their loved ones.
22 Fri, 24 May 2013 21:11:16
Re: Update on Lauren (167 replies, posted in General Discussion)
I've been reading the updates on FB that Lisa C. has been posting on Lauren's surgery. Been praying for her recovery. With you by her side, I'm sure she will be fine.
23 Fri, 24 May 2013 21:04:45
Re: New Member - Dad not getting any treatment (13 replies, posted in Introductions!)
I totally respect your dad's decision not to accept treatment. If I can be honest, in my mom's case, the treatments that she received (chemo/radiation/stents) caused more problems, hospitalizations and suffering that I feel she could have avoided if she did not receive treatments. Although reality is that if one does not receive treatment, the cancer may progress faster, but at least I feel my mom's quality of life would have been better. She was completely asymptomatic when she was diagnosed. Actually she was diagnosed by accident. She was eating well, active and feeling fine. She did started having complications once chemo/radiation started. At the time that your physician tells you that you have cancer, you are in a daze, in denial. Then you get to the stage where you want to try anything that may help. But in my mom's case, those treatments made her feel so ill, so many complications. Each treatment she received, cause a complication. She could not get a break. We were actually told that after her chemo and radiation, the PET scan came back clean, but then ONE MONTH later, she became jaundice, then all hell broke loose.
So, respect your father's choice, I now realize that QUALITY OF LIFE IS FAR MORE IMPORTANT THAN QUANTITY OF LIFE. We learned it the hard way.
24 Fri, 24 May 2013 20:54:17
Re: Hello I'm new here! (15 replies, posted in Introductions!)
Hi Terri
Very sorry what you and your family is going through.... at times I wanted to scream because I was at my wits end seeing my mom suffering so much. She endured radiation, chemotherapy, one external stent, 2 internal stents, infections, IV antibiotics, sepsis, numerous ER visits, hospitalizations. To be honest I don't know how she endured all of this for 1 and 1/2 years, because I certainly could not have. My mom left us 12 days ago, although I know she is no longer suffering, we miss her terribly.
It is ok to feel frustrated, overwhelmed, angry. This cancer robs us of our loved ones. If you feel like talking, feel free to contact me.
25 Fri, 24 May 2013 20:27:22
Topic: My Mom (9 replies, posted in In Remembrance)
My beautiful mom and best friend went home to heaven May 13, 2013. It was the day of mom and dad's 50th wedding anniversary. She left us with a smile on her face to let us know that she is in a better place. I miss her greatly. I was blessed to call her "omma" (korean for mom) for 44 years. She was the most sweetest and selfless person I know and God is lucky to have her in heaven. I cherish everyday that I got to spend with her! I love you mom!
God bless everyone who has been diagnosed with this thief of a cancer and their loved ones.


text:
Oklahoma State football: Clint Chelf ready if called
Clint Chelf stands at the ready, just in case he's called into this 2012 season.
Hoping to be called into this 2012 season.
Nothing against fellow quarterbacks Wes Lunt or J.W. Walsh, or their continued good health. But Chelf came to Oklahoma State to play.
And frankly, time is running out.
Once considered a potential heir apparent to Brandon Weeden, Chelf entered a three-man spring race for Oklahoma State's quarterback job and essentially finished third.
Yet Chelf, a redshirt junior set to graduate in December, will not surrender.
"I've just had to kind of stay strong and keep working hard and build off the mindset that you'll get the opportunity someday," Chelf said. "And that's what I've done."
Not that it's always been easy.
The months since true freshman Lunt was tabbed the starter have presented some challenges.
"They've been pretty difficult," Chelf admitted.
Still, after receiving the bad news from offensive coordinator Todd Monken in April, Chelf went to work, enlisting anyone who could help.
Even his mom, Donna.
"It's crazy, not too many families are like this, but my mom would come out and snap to me," Chelf said.
In the heat on Enid High's new artificial turf.
"Most people say that mom is the No. 1 fan," Chelf said. "Well, if there's a Super No. 1 fan for someone, it's my mom for me. She'll do anything for me — sweat, snap balls, whatever. I really love her for that. And I love my whole family."
Brother Colton, who finished his Cowboys career last fall, joined some of Clint's closest friends back home in Enid, catching "hundreds of balls a day." Clint's dad Randy, who played at OSU and serves as his son's unofficial quarterback coach, made observations and adjustments.
"Coach Monken told me it was a close competition," Chelf said. "One thing he said was that I wasn't confident throwing the ball some places. So for three months in the summer, especially when I went home in May, I worked.
"And I think I came a long way with that. Now I think I can throw any ball that needs to be thrown. I think I've definitely gotten a lot better."
But will he ever get a chance to show it?
Third-team quarterbacks receive limited practice reps, working with third-team personnel, so the opportunities to make a point — or a case — are few. And as a still-developing rookie, Lunt needs all the work he can get.
That means every snap and every pass Chelf makes needs to be perfect.
"I'm a perfectionist anyway," Chelf said. "I definitely feel like I went out there and did well (Saturday in the scrimmage). We moved the ball. I made the right reads, made the right plays. We scored two touchdowns in two drives. I think I did really well."
The rugged truth remains that Lunt is No. 1. And coaches are trying to build a package that utilizes Walsh's running skills.
And Chelf is No. 3, even though if Lunt were to struggle, or worse, get injured, Chelf appears to be the next-best option to run this offense.
Chelf said he'll continue to work and prepare and hope for his opportunity.
Monken signs off on that approach.
"And you never know," Monken said. "You lose your quarterback, now I'm the backup. And then maybe I'm the guy."
Chelf could find himself at another crossroad come December. With a degree in business management and a triple minor (finance, sports management and marketing), he'd be eligible to go to grad school somewhere else and be immediately eligible.
That's a thought for later, however.
"I'm extremely happy with where I'm at," Chelf said. "I love OSU and I'm glad to be here. I'll graduate in December. I've never been a quitter. I'll get my degree from here; I always wanted to do that. And then we'll see where that takes me.
"We'll just have to see."
So Chelf stands at the ready, just in case he's called into this 2012 season.
At some point, he wants to play.
"I'm not going to give up on that," he said, "until there's absolutely zero chance."


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text:
AN EMAIL FROM ANDREWS MOTHER (5 months later)
Andrew is thriving. We have seen and continue to see major improvements. He has matured beyond anything I can explain (I have had to rapidly adjust my parenting as I now have a much older & more sophisticated child), his comprehension (perhaps better to say his ability to express and act upon his comprehension) is now age appropriate. Though chronologically 8, we started stem cell therapy with a three year old (developmentally speaking – language at 1yr) and now have an interactive 5 or 6 year old (expressive language at 2 or 3 yrs) Since stem cell therapy Andrew can answer questions, identifies everything he sees verbally & can tell you what sound each animal makes when asked, reads aloud (albeit a bit reluctantly because speech is still a challenge, though he is able to articulate his needs and wants better than ever before). He now follows complex instructions without thought "go feed your rabbit" (involves going into the kitchen, getting lettuce out of the refrigerator closing the fridge, going outside to the rabbit pen & feeding the rabbit, closing the pen and returning inside.) Andrew helps scoop leaves out of the pool, he learned to play WII (he got a bit obsessive about it so it is limited to an hour a week), does worksheets independently, can spell virtually everything, is now using utensils to eat, asking for specific food & drink and trying many new foods. We see very little "stimming" & I have found that mimicking the "stim" draws forth a giggle which usually implies that it was being used simply out of habit & stops the behavior.
He started enjoying music and is singing and dancing since the therapy. If you stick your tongue out at him he will do it back to you and laugh – he has developed a great appreciation for little-kid slapstick humor that is definitely age appropriate (his favorite new word is "stinky" he remembered it from a "teach to Talk" video he watched when he was 5). He has started to talk on the phone and enjoys video skype a great deal. He remains completely ambidextrous but that is not uncommon in my family.
The only thing that we still have difficulty with is the television – he enjoys what we watch then at the end gets very stressed and behaves in a manner that can only be described as autistic (easily remedied – we simply don't watch the blasted thing). He will watch a show every 3-4 weeks just to see if it has changed (he still does request & enjoy tv). I can only describe it as an some sort of inappropriate neurological response to the multisensory stimuli the television offers. Do let me know if you have ever heard of children with ASD having problems with TV – most that I know use it to tune out and watch it to the exclusion of all other activities in true OCD fashion.
Interestingly, in his learning of some basic Spanish we discovered that his Spanish pronunciation is nearly perfect – far better than his English has ever been and that after using Spanish when he speaks in English his pronunciation is improved. Though there are many bilingual schools here, because we are seeing such drastic improvement I have chosen to homeschooled for the present. Here he is simply a gringo kid who doesn't speak Spanish and is perhaps a bit quirky. I feel he has a real opportunity to redefine himself and leave the autism behind if given the chance to catch up a bit before being placed in a classroom setting.
We are still seeing regular (and astounding) gains – only 3 weeks ago Andrew learned to type (motivated by his desire to query utube for discovery channel animal videos & my fingers having suddenly become too tired to type) This week he amused himself with the text to talk app on his Ipad (that he ignored for 3 years)– typing in words, saying them aloud then having the computer say them aloud as well. He is rapidly gaining the skills that will allow him to live a semi or fully independent adult life.
I must confess myself surprised to see the continued effect of the therapy five months later but one cannot deny that Andrew is still experiencing regular and significant neurodevelopmental gains. Our present course is to see where we stand next spring and with your help determine if an additional course of SCT is in order.
Phone: 1-800-234-1693
Email: firstname.lastname@example.com
Website: www.worldstemcells.com
Autism Page: http://worldstemcells.com/stem-cell-therapy-autism.html


text:
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text:
2009: Named third-team All-MPSF despite struggling with injuries for most of the season ... Finished 13th in the country in blocks per game (1.36/game), while also ranking 14th in the country in hitting percentage (.402) and 35th in aces per game (0.34/game) ... Finished sixth in the MPSF in blocks and ninth in service aces ... Led Long Beach State in block assists (123), blocks (130) and blocks per game, while also finishing with 205 kills, 2.16 kills per game and 30 service aces ... Finished with double-digit blocks twice, including a career-high 14 (the sixth most in school history) against UCLA ... The 14 were all block assists tying a school record ... Had a double-double (10 kills/10 blocks) in a win over Penn State ... Recorded double-digit kills 13 times, including a career-high 18 at Stanford ... Finished with a season-high .714 (10-0-14) hitting percentage in the season opening win over eventual national champion UC Irvine ... Named MPSF co-Player of the Week on April 13 after helping LBSU to wins over UC Santa Barbara, with 10 kills (.588) and six blocks, and Cal State Northridge, with 10 kills (.467) and six blocks ... Tied a LBSU postseason record with three service aces in MPSF quarterfinal match at Pepperdine, while putting up the third best hitting percentage (.700) in LBSU postseason history.
2008: Earned American Volleyball Coaches Association All-America first-team honors ... A first-team All-MPSF selection ... Played in 103 games, averaging 2.65 kills and a team-high 1.48 blocks per game while hitting .503 ... Finished second in the country in hitting percentage and fourth in blocking ... 273 total kills were third-most on the squad ... Third on the team with 31 service aces ... First on the team with 152 total blocks and 148 block assists ... Hit double-figures in kills 13 times and in blocking three times ... Had a career-high 18 kills and hit .818 against Ohio State on Feb. 22 ... Had 10 block assists on Jan. 30 against Pepperdine, on Feb. 8 against UC San Diego, and on Feb. 29 against Cal State Northridge ... Recorded two double-doubles in kills and blocks on Feb. 8 vs. San Diego and on Jan. 30 vs. Pepperdine ... Led the squad in blocking in 20 matches.
2007: Appeared in 71 games ... Averaged 2.01 kills and 1.23 blocks per game while hitting .375 ... Finished third on the team with 16 service aces ... 87 total blocks were fourth on the squad ... Finished 10th in the MPSF in blocking at 1.25 blocks per game ... Moved into the starting lineup mid-way through the year ... Hit .769 (11-1-13) against Cal Baptist on Feb. 9 and hit .706 (14-2-17) against Penn State ... Was named to the Active Ankle/Long Beach Guesthouse Classic All-Tournament Team ... Hit .500 and averaged 2.00 kills and 1.30 blocks per game as the 49ers defeated IPFW and Penn State ... Had 17 kills against Pepperdine on March 24 ... Career-best 12 blocks (12 BA) on April 6 vs. Hawaii ... Led the squad in blocking in six matches ... Tallied nine blocks on March 29 at BYU and eight at Stanford and at home against Penn State, both victories.
2006: Redshirted for the 49ers.
High School: Selected second-team All-American in 2005 by Mizuno/Volleyball Magazine ... Prepped at Arcadia High School where he lettered three years in both volleyball and basketball ... Was voted Arcadia High School's Athlete of the Year ... Selected first-team All-CIF in volleyball as well as All-Pacific League ... Helped lead Arcadia to three consecutive Pacific League championships ... In basketball, helped lead the Apaches to a second-place league finish and once scored 45 points in a game.
Quick Facts: Named to the Principal's Recognition Roll as a prep athlete ... Competed for the Riptides club team for two years out of Redondo Beach ... Team won the 2005 Junior Olympics and Alexander was named to the All-Tournament team ... A Volleyball Magazine "Feb 50" recruit ... Named a 49er Academic All-Star in Fall 2006.
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The 11th-ranked Long Beach State men's volleyball team made its fifth-straight MPSF Tournament...
Long Beach State Falls at No. 3 Hawai'i in MPSF...04/25/2015 - M. Volleyball
The 11th-ranked Long Beach State men's volleyball team dropped a tough three-set decision to No. ...
Two 49ers Named to All-MPSF Men's Volleyball Team04/23/2015 - M. Volleyball
Juniors Taylor Gregory (Saugus, Calif.) and John La Rusch (Long Beach, Calif.) have been named to...
LBSU Men's Volleyball Begins MPSF...04/22/2015 - M. Volleyball
The seventh-seeded Long Beach State men's volleyball team will make its way to Honolulu this...
Beach Defeats CSUN in Five Sets on Senior Night04/18/2015 - M. Volleyball
The 11th-ranked Long Beach State men's volleyball team closed out the regular season in dramatic ...


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- 193Promote
Tote Bag
Prelude to Duskby Olivia Joy StClaire
Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
beach, light, dunes, sea...
Love it, the tones, the light, magical
Lovely!! Gorgeous bokeh!! ♥♥♥
Wow, sooo beautiful Joy!! Very pretty bokeh!
Love it!
very elegant and beautiful, Olivia!
Beautiful picture!
Gorgeous image!!!
gorgeous feeling gives me :))
Bokeh Beauty! :)
Thanks so much for your kind comment lovely peeps!
Thanks so much for your kind comment lovely peeps!
beautiful and dreamy!
woohoo!! Thanks for letting me know Lyle! xoxoox
Sooo sooo sooo gorgeous, as always!
xo Thanks Sandra & Josie!
Beyond gorgeous!
Thanks Marte! :)
Beautiful !!
The bokeh is great...
Fantastic piece of art, as always :)
The bokeh is great...
Fantastic piece of art, as always :)
Thanks for the sweet comment Thomas!
Wonderful colours .... !
♥ Thanks Moni!
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