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Josh Campbell, Ph.D.
Postdoctoral Associate, Spria-Lenburg lab | Meyerson Lab (Broad Inst.)
B.A. Biology, Computer Science, & Math; Anderson University, Anderson, IN, 2007
Ph.D. Bioinformatics, Boston University, Boston, MA, 2012
Contact Information
Email: firstname.lastname@example.com
Office: E636
Research Interests
Identifying drivers of lung cancer. Lung adenocarcinomas and lung squamous cell carcinomas are the most common types of lung cancer and remain major causes of death worldwide despite advances in smoking cessation, early detection, and targeted and immunological therapies. Many patients have lung cancers that do not harbor a known activating mutation and therefore cannot be given targeted therapies. In the lab of Matthew Meyerson, I analyze next-generation sequencing data generated from consortiums such as The Cancer Genome Atlas (TCGA) to identify novel drivers of lung tumorigenesis. Targeting these genes with novel therapies will hopefully lead to a reduction in overall lung cancer mortality.
Lung cancer alterations in tumors from African-Americans. Lung cancer incidence and mortality are both higher for African-Americans, most notably in males. In a collaboration with the lab of Matthew Meyerson and the Center for Cancer Genome Discovery (CCGD) at DFCI, I am exploring profiles of somatic alterations in lung tumors from African-Americans and Caucasians. Understanding differences in mutational frequencies between ethnicities can lead to the reduction of disparities by enabling more precise targeting of patients with appropriate clinical modalities.
Premalignant lesions in lung cancer. Lung squamous cell carcinoma (SqCC) remains a leading cause of cancer mortality in the US, with more than 50,00 death annually, due to late stage diagnosis and lack of effective treatments. In the Spira/Lenburg lab, I am examining premalignant lesions in the airways of high-risk smokers to better understand the genetic alterations that contribute to the progression of squamous cell carcinoma.
Therapeutic development and pathogenesis of COPD. Chronic Obstructive Pulmonary Disease (COPD) is the 4th leading cause of death in the world. Our understanding of the molecular mechanisms responsible for the initiation and progression of this disease are limited. By examining gene and microRNA expression differences between individuals with and without COPD or differences within a person along a gradient of disease, I hope to elucidate the molecular mechanisms behind this disease. Utilizing publicly available resources such as the Connectivity Map, I also hope to use gene expression data to predict novel therapeutics for the treatment of COPD.
Tagne JB, Mohtar OR, Campbell JD, Lakshminarayanan M, Huang J, Hinds AC, Lu J, Ramirez MI. Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb. Respir Res. 2015 Feb 13;16(1):22
Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M6, Geraci M, Quackenbush J, Sciurba F, Schwartz DA, Kaminski N, Johnson WE, Monti S, Spira A, Beane J, Lenburg ME. Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 2015 Feb;21(2):164-71.
Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell JD, Lin L, Huang T, Tu Z, Feronjy R, Spira A, Schadt EE, Charles Powell CA, Zhu J. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan 8;11(1):e1004898.
Lamontagne M, Timens W, Hao K, Bossé Y, Laviolette M, Steiling K, Campbell JD, Couture C, Conti M, Sherwood K, Hogg JC, Brandsma CA, van den Berge M, Sandford A, Lam S, Lenburg ME5, Spira A, Paré PD, Nickle D, Sin DD, Postma DS. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. Thorax. 2014 Sep 2. pii: thoraxjnl-2014-205630.
Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J. MODMatcher: Multi-Omics Data Matcher for Integrative Genomic Analysis. PLoS Comput Biol. 2014 Aug 14;10(8):e1003790.
Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31;511(7511):543-50.
Christenson SA, Brandsma CA, Campbell JD, Knight DA, Pechkovsky DV, Hogg JC, Timens W, Postma DS, Lenburg M, Spira A. miR-638 regulates gene expression networks associated with emphysematous lung destruction. Genome Med. 2013 Dec 31;5(12):114.
Perdomo C, Campbell JD, Gerrein J, Tellez CS, Garrison CB, Walser TC, Drizik E, Si H, Gower AC, Vick J, Anderlind C, Jackson GR, Mankus C, Schembri F, O'Hara C, Gomperts BN, Dubinett SM, Hayden P, Belinsky SA, Lenburg ME, Spira A. miR-4423 is a Primate-Specific Regulator of Airway Epithelial Cell Differentiation and Lung Carcinogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18946-51.
Steiling K, van den Berge M, Hijazi K, Florido R, Campbell JD, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1;187(9):933-42.
Campbell JD, McDonough JE, Zeskind JE, Hackett TL, Pechkovsky DV, Brandsma CA, Suzuki M, Gosselink JV, Liu G, AAlekseyev YO, Xiao J, Zhang X, Shizu Hayashi, Joel D. Cooper, Timens W, Postma DS, Knight DA, Lenburg ME, Hogg JC, Spira A. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 2012 Aug 31;4(8):67.
Piccolo SR, Sun Y, Campbell JD, Lenburg ME, Bild AH, Johnson WE. A single-sample microarray normalization method to facilitate personalized-medicine workflows. Genomics. 2012 Aug 19.
Beane J, Vick J, Schembri F, Anderlind C, Gower A, Campbell JD, Luo L, Zhang XH, Xiao J, Alekseyev YO, Wang S, Levy S, Massion PP, Lenburg M, Spira A. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq. Cancer Prev Res. 2011 Jun;4(6):803-17.


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We learn that Don's marriage is by no means perfect, and his son, the team's star pitcher, has interests outside of baseball that his father cannot abide. Michael is struggling as a single parent. The initial resentment between the two men softens as they learn more about each other.
Rounding Third is certainly an odd couple concept, and Sherman and Schlotterbeck make the most of their characters, helped by Caren Young's appropriate costuming — Don wears jeans, T-shirts and a ball cap, while Michael shows up in a tweed sport coat, white shirt and tie, later in a yellow rain slicker when inclement weather is threatening.
Sherman's Don is loud and impatient. He expects his reputation to make him a guy to be respected and that the kids will snap to his commands. (We never see the kids on the team, but director Bob Brunner has the coaches, especially Sherman's Don, address pep talks and advice to the audience — with appropriate pauses for expected responses.) Michael is a collection of nervous tics and apologetic explanations. There's no question why he was always picked last when sports teams were being chosen when he was in school. But he's more likeable than Don because he's doing this for his son, rather than for his own ego. (In fact, he's doing it despite his own self-confessed ineptitude.)
Each man has something to learn from the other. I'm not going to say these lessons are very profound, but playwright Dresser does provide some moments that are amusing and others that show that people who are fundamentally different can learn from one another. His ear for the ways guys, especially Dan, talk about sports is very accurate, and Michael's challenges to Dan's reasoning make for some good moments that ring true. Sherman and Schlotterbeck do a good job of bringing these wildly different men to life.
Nevertheless, the predictability of this story is barely enough to sustain two acts (just a little more than two hours) of interaction: It's clear from the opening moments that they're going to have a hard time getting along; by the second scene, we begin to get glimpses that they'll each absorb something meaningful from their opposite's point of view.
Richard Dresser, who has had numerous scripts produced at the renowned Humana Festival of New American Plays in Louisville, Ky., is an accomplished dramatist with a flair for everyday characters that speak like real people (and use language and topics that might put off a few audience members). I don't think Rounding Third is Dresser's best work, but this pleasant production entertained the opening night audience on the Showboat, mostly older folks who subscribe and come to see each show of the season whether they've heard of it or not.
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subset: commoncrawl


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Aaron Sorkin and Dave Itzkoff sat down for a discussion of the film "Network" at the Paley Center for Media, providing quite the background on a film almost four decades old.Read More »
"A movie about Facebook? Good luck"—that was the sentiment of many upon first hearing about "The Social Network," but they underestimated the talent involved. Featuring a crackling script by Aaron Sorkin and precise, energetic direction by David Fincher, the film was less about the actual website, a...Read More »
The 2014 Tribeca Film Festival introduces Tribeca Innovation Week (TIW), a project that will focus on closing the gap between the creative and tech worlds.Read More »
The 2014 Tribeca Film Festival is launching its first-ever "Tribeca Innovation Week." Running April 21-26, the Innovation Week will be a place for coders, screenwriters, hackers, futurists, gamers, directors, engineers, venture capitalists, film financiers, techno radicals, the generally curious and...Read More »
Is HBO cleaning house, and perhaps sweeping away dead or underperforming weight? Just one week after the cable network announced the upcoming fifth season of "Boardwalk Empire" would be its last—news which surprised many of its fans—HBO announced that Aaron Sorkin's troubled drama "The Newsroom" wou...Read More »
Was he playing it close to the vest, did slow ratings just catch up with the show, or did creative discussions yield a different approach? I interviewed "Boardwalk Empire" creator/head writer Terence Winter at the end of the fourth season late last year, and when I asked him if there was an end in s...Read More »
HBO knows how to throw a good bash, and their annual Emmy after-party at the Pacific Design Center was a huge improvement on the sad and gloomy death-obsessed 65th Emmy Awards, which nonetheless drew the largest audience in eight years. Who are these mythical TV Academy voters who misled most of th...Read More »
Before diving in, a bit of a disclaimer and/or explanation is in order. Thanks to TIFF taking me away from the television for a couple of weeks, followed by some bungling couriers and concluding in massive fatigue upon returning from Toronto, "The Newsroom" slipped off the immediate radar. And a sho...Read More »
The second season of Aaron Sorkin's HBO drama "The Newsroom," which wrapped last night with an episode entitled "Election Night, Part II," continued to weave in the real news stories the show has used as guideposts along its rerunning of recent history -- the Mitt Romney campaign, the execution of T...Read More »
When the season began, with talk of a lawsuit and of the need to immediately retract a huge story -- a claim that U.S. troops had committed a war crime by using sarin gas on civilians -- it appeared that institutional bias was indeed likely to be a culprit, the slant view of liberal journalists who ...Read More »


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Use the tools below to refine your search by only displaying reviews with a certain number of star ratings or to only show reviews from a certain time period. Eg click on '1 star' to just display the reviews we have which received a 1 star rating click or 'Within the last month' to display just reviews posted over the last month.
Written on: 08/10/2008 by steve2008beijing (1 review written)
My preferred application and online community to share pictures, videos and more with my friends. I got Nokia, some of my friends use iPhone now, every one can check and share without bothering about phone brands: I like the spirit of the service!… Read Full Review
Written on: 09/09/2008 by simon2008 (1 review written)
Mobicue www.mobicue.com is freeware that allows you to upload pictures and videos from your mobile phone onto a personal homepage on the web. It's nice because I can finally share pictures and videos with my friends without having to pay to send everyone an MMS.
I also have internet access on my mobile, so I can also browse to their website and look at other people's uploaded content.
All in all, a nice program that makes picture and video sharing with a mobile much easier… Read Full Review
As rated by our community of reviewers
" Now a day's Google android is the most popular and best mobile oper... " Read More
Written by SimpsonForte
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" Do not fall for the 1 review that obviously comes from them...do no... " Read More
" Unlocking code for Samsung " Read More
Written by DeeBell


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May 24, 2016
Bay opening district play against undefeated Godby. The Cougars improve to 4-0 with a 21-7 win over the Tornadoes, who drop to 1-3 overall.
Bozeman with their home and district opener against Chipley last night. The Tigers also remain perfect with a 35-13 win over the Bucks; Josh Potter with a 95 yard touchdown run.
The weather was a major factor in Blountstown as the Tigers took on FSU High. Look at the conditions, but needless to say it was a low scoring affair. The Tigers are shutout at home 7-0 and drop to 2-2.
In 1-A District 1, Freeport beat Wewa on the road, 14-6.
Back to Panama City Beach, an intra county matchup between Rutherford and Arnold, a thriller as the Marlins win 18-16. They're 2-2, the Rams drop to 1-3.
And finally a little to the west, an Okaloosa County rivalry, Niceville defeats Choctaw 41-34 in a shootout.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


text:
I use a SWF file that exposes functions and events using ExternalInterface. Here is an example of an exposed function:
ExternalInterface.addCallback("myFunction", ExecuteMyFunction);
If I embed the file in an HTML page, I can access those functions using JavaScript.
Now, I'm embedding that same SWF file dynamically in a Flex app using the mx:SWFLoader component, something like:
<mx:SWFLoader id="myLoader" source="http://localhost/file.swf" autoLoad="true"/>
I'm trying to access those exposed functions and events, but I can't find how to interact with those from the Flex app. I would like to be able to call a function just like from JavaScript, like:
How can I access a function that is exposed by the ExternalInterface within Flex?


text:
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Bellville ISD and First Financial Group of America would like to take this opportunity to present to you the benefit information for the upcoming plan year. This informational website has been created to bring forth a brief overview of your benefit choices as well as offer you a reference guide when questions arise regarding your insurance plans.
Please take the time to look over the information contained on this website to familiarize yourself with the benefits that are provided to you as an employee of Bellville ISD.
Important Information for 2015/2016 Plan Year
Open Enrollment for the New Plan Year for Supplemental Benefits
- The Plan Year for Bellville ISD is September 1 – August 31.
- Open enrollment will be held May 11 – 25, 2015. Representatives will be in the district May 18 – 22, 2015 to review plan options and assist with your supplemental benefits enrollment.
- New Employees have 31 days from their hire date to enroll in benefits for the 2015/16 Plan Year. If you do not elect benefits during this window you will have to wait until the next open enrollment and be subject to all pre-existing condition limitations. New employees will be required to go online and enroll in your benefits.
- Click Here for online enrollment instructions.
Whats New for 2015/2016
- The annual dollar limit on employee contributions to employer-sponsored healthcare flexible spending arrangements (FSA) rises to $2,550, up $50 dollars from the amount for 2014.
- FF Flex Mobile App
- The annual contributions for a 457 plan has increased to $18,000 for 2015. Please see your plan representative for more information.
- The annual contribution for a 403(b) has increased to $18,000 for 2015. Please see your plan representative for more information.


text:
Manual Solutions › Visitor Pass Registry Book › Large Badges
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text:
Windows 7 Professional 750GB Hard drive, no corruption, chkdsk shows now errors.
I installed a new internal 1TB hard drive in the laptop. Plugged in the 750GB drive via USB enclusure.
I copy over files (a folder of jpgs for instance).
If I view them on the USB enclosure, or if I view the copied files, they are corrupted. Chkdsk on the good usb drive shows tons of corruption. But if I put the 750GB drive back in and bot, everything looks OK.
What could the problem possibly be? At a total loss here.


text:
Manchester United Message Board
A Yahoo! User Mar 16, 2008 00:02 Flag
MOTM: The 12th Man
Once again our away fans were superb, none of the players came close to being as good.
Should/could of been 5-0 up within the first 15 minutes, typically, from not finishing our chances the opposition grows in confidence for their cup final - as always we are a victim of our own success, of being United.
The two keepers stood out. Carroll stopped Ronaldo from having two hatricks. Foster made two world class saves that show why he is the only choice for England. How important could those two saves be...
Anyone who wasn't sure how much we rely upon Ferdinand wonder no more. We missed him more than we would have missed any other defender, just for his organizational skills alone.
All in all it was difficult to watch, but thank f*ck we have the 3 points. Over to you Francenal....Sort: Newest | Oldest | Most Replied Expand all replies
As I said in another thread, its the business end of the season now, and all that matters is getting the three points. It doesnt matter how or in what manner we do it, as long as we get all three!
We did that today so job done and one more game out the way.
Good point about Rio, and it's true, both keepers played brilliantly.
I was also glad to see that Saha was only injured for a week this time, and got on the pitch for a bit. If his injury periods keep getting shorter, maybe he'll actually manage to play 3 games back-to-back this season ;-)


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It should come as no surprise that "Mad Men," a drama about a 1960s advertising firm, has designed what it hopes to be an unforgettable send-off campaign.
The pioneering AMC series will launch its seventh and final season on April 5 — culminating in a swan song that probably will generate the kind of frenzied chatter last seen by its sister drama "Breaking Bad" in 2013.
To rally viewers as the end draws near, the network is promoting the final stretch of the drama with a multimillion-dollar marketing campaign. There's even a black-tie ball for its premiere.
"This show changed our network, period," AMC President and General Manager Charlie Collier told The Times. "This show means something as our first, and we wanted the send-off to reflect that."
The drama, created by Matt Weiner and produced by Lionsgate, made its debut in 2007. Despite undersized ratings, it was praised by critics and would go on to ingratiate itself into the zeitgeist — spawning countless analyses and even a reference by President Obama during last year's State of the Union address. It became part of the disruptive basic-cable troop that demonstrated good shows with a lasting effect were not limited to broadcast and premium cable.
And as the first breakthrough drama for AMC, once a repository for classic movie reruns, it helped the network establish itself as a destination for high-quality content, paving the way for such shows as "The Walking Dead," "Breaking Bad" and "Better Call Saul."
In place of a thank-you note for the drama that's been crucial to its rise, AMC is getting creative.
A major component of the goodbye was a 60-second retrospective commercial that aired during the Academy Awards. It was a minute of airtime that didn't come cheap, probably costing the network as much as $3.5 million for the time — slightly more than the average cost to produce one episode of "Mad Men."
It's just a fraction of the send-off that is sizing up to be more elaborate than that of "Breaking Bad."
A smattering of "Mad Men" testimonials — from the likes of Bryan Cranston and, even, Keith Olbermann — have rolled out on the network during commercial breaks for "The Walking Dead" and "Better Call Saul." A drip-drop of promotional images have hit the Internet and will adorn billboards, bus sides and telephone kiosks.
In a nod to its mark on popular culture, it will join the permanent collection at the Smithsonian National Museum of American History next month — with Don Draper's gray suit, fedora and bar cart slated to be on display. Numerous other events at major cultural institutions in New York and Los Angeles will also take place.
There will also be an art installation outside the Time-Life building in Manhattan — the building that served as the fictional home of Sterling Cooper & Partners.
Linda Schupack, executive vice president of marketing for AMC, said the campaign adheres to the idea of it being the end of an era in more ways than one: The characters of "Mad Men" are moving on from the 1960s, while viewers are saying goodbye to a drama that helped usher in the new golden age of TV.
"We have been thinking about this for a very, very long time," she said. "The only way to go pay tribute to a show that is unlike any other is to go out big."
Of course, the cable network — a unit of AMC Networks Inc. — is hoping the big-budget drama goes out big in other ways.
At its peak in Season 5, the drama averaged 4.16 million viewers — about one-fifth of what "NCIS," the top broadcast drama in total viewers that year, garnered. Despite "Mad Men's" modest audience, the network has seen an uptick in advertising revenue thanks in part to the upscale audience the drama attracts with its patient, highbrow storytelling.
AMC's ad revenue for 2014 was $469 million, up 7 percent from the previous year, according to SNL Kagan, an industry consulting firm. To be clear, "Mad Men" isn't responsible for it all, but the show does command higher ad rates than some broadcast network programs with larger audiences.
The last seven episodes of the period drama are expected to nab top-dollar advertising rates for cable television among marketers trying to align themselves with Don Draper and his Madison Avenue cohorts before it ends. Its final beat is likely to produce the highest revenue in the show's run.
A 30-second spot in the final episode is currently commanding $400,000, and is expected to approach $500,000. For perspective, a "big hit" on a broadcast network might fetch around $200,000 to $300,000.
AMC Networks should generate nearly $2.6 billion in revenue, a 17.4 percent increase over 2014 levels, according to the research firm's estimate.
It's the kind of outlook that Don Draper might celebrate over an old fashioned.
For Weiner, the notoriously secretive creator at the helm of "Mad Men," the celebration is in looking back as the network moves forward.
"It was exciting to be at the start of something where there were no rules and where everyone had an optimistic attitude despite limited resources and a seemingly impenetrable marketplace," he said by email. "We're all still processing the fact that it worked out."


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1. Mark E. Neely, Jr. Confederate Bastille. Jefferson Davis and Civil Liberties. 1992.
2. Richard Nelson Current. What Is an American? Abraham Lincoln and "Multiculturalism." 1993.
3. Robert W. Johannsen. The 'Wicked Rebellion' and the Republic: Henry Tuckerman's Civil War. 1994.
4. Gary W. Gallagher. Jubal A. Early, the Lost Cause, and Civil War History: A Persistent Legacy. 1995.
5. John Y. Simon. Grant and Halleck: Contrasts in Command. 1996.
6. Edward L. Ayers. Momentous Events in Small Places: The Coming of the Civil War in Two American Communities. 1997.
7. Phillip Shaw Paludan. War and Home: The Civil War Encounter. 1998.
8. Catherine Clinton. Public Women and the Confederacy. 1999.
9. George Rable. News from Fredericksburg. 2000.
10. David W. Blight. Frederick Douglass and Abraham Lincoln: A Relationship in Language, Politics, and Memory. 2001.


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The Freeling family is a typical middle class family living in the peaceful Cuesta Verde Estates. Steve, his wife Diane, 16-year-old daughter Dana, 8-year-old Robbie, and 5-year-old Carol Ann live in a tract house. Soon strange things begin to happen around the house; the pet canary dies, mysterious storms occur, and Carol Ann is summoned to the TV set, where a strange shaft of green light hits her and causes the room to shake. As the curious events continue, Carol Ann is repeatedly drawn to the television, where she begins to talk to "the TV people." Soon Carol Ann is sucked into a closet, disappearing from this reality plane. Unable to find his daughter, Steve consults Dr. Lesh, a para-psychologist from a nearby college. Lesh finds that the paranormal phenomena is so strong in the Freelong household she is unable to deal with it and sends for clairvoyant and professional exorcist Tangina to examine the house in hopes of finding Carol Ann. Tangina makes a horrifying discovery: Carol Ann is alive and in the house, but is being held on another spectral plane
Call Number:Horror


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After the Easter Bunny hops back into his rabbit hole, thank your friends and family for joining your celebration with the Easter Personalized Thank You Note. Bright and cheerful, this note card features the Easter Bunny and your customized message. Each thank you note is sold with a white envelope.
Hints: Your text will automatically align in the Preview when typing, use the Enter key to create a new line.
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Dear Susan,
Last week was the "Women Tell All" special. I didn't recap it for you because a) the women did not tell all – they mostly spent their time crying, complaining about what someone else said, and accepting apologies – which means that it was also b) BORING. I cannot thing of one thing that I would tell you about it so we'll just move on to last night's 3 hour finale extravaganza.
Despite how boring this season has been, I found myself really into last night's episode. I'll tell you one thing, The Bachelor editors are pretty good at their jobs. They made Becca, the most on-the-fence person to ever be on this show, seem riveting. However, as I go through my notes, I am realizing that once again, this season with Farmer Chris was just incredibly boring. Continue reading


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State troopers have charged the driver of a pickup truck who ran over and killed a Grifton Man Monday night.
59-year-old John Locust was charged Wednesday with death by motor vehicle.
Troopers say Byron Brown of Grifton died in the fiery crash on Highway 11 in Lenoir County. Brown became trapped underneath the pickup truck which then burst into flames.
Wednesday's Update
The name of the person killed in Monday's moped accident has been released.
Highway Patrol Troopers say 49-year-old Byron Brown of Grifton died Monday. Charges are pending against the driver of the truck as troopers are still investigating.
The investigation continues into how the rider got trapped underneath a pickup truck which then burst into flames.
There's not much of left of the moped to make out, except for the handle bars. Troopers say the rider collided with the truck on Highway 11, between Grifton and Kinston.
The bike then burst into flames with the rider trapped underneath. The driver of the truck was able to escape the burning vehicle.
State law doesn't forbid these bikes to be on the highway, but motorcycle safety experts say, since moped can only travel 35 miles per hour or less, it's too dangerous for them be on road with speeds above 45.
The state does not require motorcycle safety courses, license or insurance to ride these types of vehicles the only requirements, that you're over 16 year old and wear a helmet.
Original story:
One person is dead following an accident just north of Kinston on Highway 11.
Law enforcement officials tell WITN a moped and a pickup truck collided around 6:00 p.m. The driver of the moped was killed.
Detours were set up around the accident just south of Grifton. Highway 11 has since re-opened.


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BOLIVIA — It took a moment for Brunswick County Sheriff's Deputy Samantha Lewis-Chavis to compose herself before she described watching 18-year-old Keith Vidal die.
"I watched Mr. Vidal's eyes go from black, just like somebody suffering from a mental illness (has), to a normal color and I watched death come into his eyes," she said, tears streaming down her face. "You could see the innocence in a person, a scared look. I watched his eyes go to death and he fell to the ground."
Leland police are asking for the public's help to identify a woman involved in a vehicle break-in.
Officers received a report of a motor vehicle break-in Jan. 15 at 2013 Olde Regent Way where many items were taken, according to a news release. The next day, the victim learned three unauthorized checks totaling about $2,800 had been cashed from his account.
Anyone with information about the white woman with dark hair and glasses pictured in a surveillance image provided by Leland police is asked to call Detective Felicia Garnes at 332-5005.
By Lindsay Kriz
Staff Writer
BOLIVIA — "It was the frickin' loudest Taser I've ever heard."
This was the first thought Boiling Spring Lakes Police Cpl. John Thomas had upon hearing the gunshot Bryon Vassey fired, killing 18-year-old Keith Vidal more than two years ago.
SHALLOTTE — A woods fire burned 20 undeveloped acres behind New Beginnings Community Church and ATMC offices on Whiteville Road on Wednesday afternoon.
North Carolina Forest Service spokesman Brian Haines reported two bulldozers were able to plow a fire line to keep the fire from spreading.
The fire started west of Ruby Way NW, where Shallotte Fire Department trucks and the Forest Service protected ATMC buildings that extend along Ruby Way as well as several manufactured homes further down the road.
Crews from the Shallotte and Ocean Isle Beach fire departments responded to a fire at 5065 Northside Drive about 5:30 p.m. Tuesday, April 19.
Homeowner Ray Whitley said he and his wife, Tabitha, who lived at the residence for the past three years, were in the house when they heard a series of pops and then more than one smoke alarm went off inside the house.
Ray Whitley suffered a burn on his head when he tried to fight the fire with an extinguisher before he and his wife escaped with their pets.
The cause of the fire has not been determined.
LELAND — Mountain biking enthusiasts are blazing a trail for a racing league for students in northern Brunswick County.
Mike Long, director of the North Carolina Interscholastic Cycling League, part of the National Interscholastic Cycling Association (NICA), hosted the first organizational meeting April 9 at the Leland Port City Community Church (PC3) offices.
Don Brown, PC3 Leland campus pastor, is a member of the North Carolina NICA board.
LELAND — The weather forecast and the North Carolina Department of Transportation schedule for creating the new diverging diamond interchange (DDI) at N.C. 133 at U.S. 17/74/76 finally aligned over the weekend.
To prepare the DDI, which runs under the highway on N.C. 133 between Leland and Belville town limits, NCDOT had to close N.C. 133 — Village Road in Leland, River Road in Belville — between the U.S. 17/74/76 interchange ramps.
LELAND — Leland economic development director Gary Vidmar encourages public input on the first draft of the town's 2020 Master Plan.
The plan, discussed at the Leland Economic Development Committee meeting April 14, addresses the town's population increase, vision for land use, parks and open space, transportation and economic development.
Leland officials brought in PlaceMakers Consulting Team on Nov. 10-13, 2015, to help update the plan. In the 2009 version of it, residents said they wanted compact, walkable and mixed-use development.
BOLIVIA — Brunswick County commissioners voted 4-1 Monday to place the school board's requested $152 million bond referendum for school capital needs on the Nov. 8, 2016 general election ballot.
Commissioner Marty Cooke, who has been critical of the school board's planning and timing of the bond request since a joint meeting with the board on Nov. 23, cast the dissenting vote during commissioners' regular meeting Monday night, April 18. His wife, Catherine Cooke, is a school board member.
LELAND — Ready.
This was the goal for elementary school students at Roger Bacon Academy's Charter Day School in Leland on April 12 during the 12th annual FASTAR event.
FASTAR is an academic competition for students in kindergarten through fifth-grade that revolves around a NASCAR theme. Participating students had been training for the event since January, Roger Bacon Academy (RBA) spokeswoman Sawyer Batten said.
Copyright © 2016
The Brunswick Beacon is your source for local news, sports, events and information in Brunswick County, North Carolina and surrounding areas.


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- 60Promote
Stationery Cards
Night timeby Matt Saunders
Set of folded stationery cards printed on bright white, smooth card stock to bring your personal artistic style to everyday correspondence. Each card is blank on the inside and includes a soft white, European fold envelope for mailing.
Love it!
Is there anyway I can see a close up of the people? I want to buy this as a gift for my girlfriend but I'd like to see some more detail first. Thanks!
Hi drop me an email I can sort that out, matt.rabbitportal At google mail dot com
Love this.
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Tuesday, September 15, 2009
Fabulous face painting
Posted by Sharnel at 4:08 AM
2 comments:
Wow. How do they do this. Hope you received the swallows Sharnel. I posted them about 2 weeks ago.ReplyDelete
Thank you so much Simone. I did receive them and they are gorgeous. I've got them sitting in my scullery, waiting for someone to hand them for me. I think i'll have to do it myself!ReplyDelete
Thank you again. x
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I have it: 10 I had it: 1 I want it: 8
Designers » B » Black Phoenix Alchemy Lab Floral Fruity Gourmand « Groups
I have it: 10 I had it: 1 I want it: 8
Bon Vivant by Black Phoenix Alchemy Lab is a Floral Fruity Gourmand fragrance for women. The fragrance features champagne and big strawberry.
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|long lasting
|very long lasting
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I received a sample of this. Bubbly, for sure, but more like ginger ale to me. I kept waiting for strawberries, but never got them! Still, quite delightful. My husband commented favorably on it, but also added, "A little goes a long way." A great scent for a summer party.
Yum! Its bubbly, sweet, and perfectly festive. Its great for special occasions. I thought the imp would be enough, but it got used up fairly quickly. Wants more noms!
A bubbly strawberries and champagne fragrance. I can almost feel the champagne bubbles when wearing this- it really sparkles. The perfect fragrance for celebration.
"An effervescent blend of crystalline champagne notes and sweet strawberry."
Ok, Bon Vivant....................
I'm gonna keep it short and sweet, It does basically smell like strawberries and champagne, but.... the champagne smell is not like a real alchohol smell. It's more likened to Yvresse by YSL. It's basically "that" with a background of strawberries.
Ok that was possibly the lamest review in history but it's the only way I can think to describe it! Sorry hehe!
Become a member of this online perfume community and you will be able to add your own reviews.
This page contains information, reviews, perfume notes, pictures, new ads, vintage posters and videos about Black Phoenix Alchemy Lab Bon Vivant fragrance but we do not warrant the accuracy of information. Trademarks and logos belong to respected companies and manufacturers and are used solely to identify products and companies. If you have more information about Black Phoenix Alchemy Lab Bon Vivant, you can expand it by adding a personal perfume review. Fragrantica has a unique user-driven classification system and you may classify Bon Vivant by Black Phoenix Alchemy Lab. Click on the appropriate options on the fragrance classification form below the perfume picture. Also, you can find links to 3rd party websites/Internet stores, but Fragrantica has no access or control over those websites. We do not make guarantees nor accept responsibility for what you might find as a result of these links, or for any future consequences including but not limited to money loss. User reviews of Bon Vivant by Black Phoenix Alchemy Lab represent the views of the credited authors alone and do not reflect Fragrantica's views.
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I have always been crafty but decided to make it into a career 4 years ago. I completed a 2 year diploma program in Jewellery Art & Design. I am now a stay-at-home-mom to a beautiful daughter. I have a home-studio and am a founding member of the North Columbia Artist's Coop here in beautiful Revelstoke BC.
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Delridge Produce Cooperative is giving away free fruits and vegetables from rotating "mobile markets" along Delridge Way Southwest. The co-op hopes to eventually open a nonprofit produce store in a neighborhood that one local resident calls a "healthy-food desert."
There may be only one thing harder to do along Delridge Way Southwest than finding fresh produce for sale: giving it away for free.
Such was the case Sunday at a temporary produce stand on the main drag of a Southwest Seattle neighborhood so bereft of grocers that one local resident calls it a "health-food desert." Passers-by waved off offers of peaches, apples and homegrown squash with the quizzical air of people surprised to have free organic bounty thrust upon them.
Galena White understands.
White, a former fast-food worker, including at Subway and Roundtable Pizza, is board president of Delridge Produce Cooperative. The co-op — launched this year with a $15,000 grant from the city of Seattle — aims to educate residents about adding green to their diets by seeking out fresh produce. The co-op eventually hopes to become a nonprofit produce purveyor and open a permanent store.
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The co-op began a four-week demonstration Friday by opening a produce stand in front of Watts Electric Service. The next day, it moved down Delridge Way Southwest to Care A Lot Daycare.
Sunday it was at Delridge P-Patch. Today, it will set up shop at Youngstown Cultural Arts Center.
The mobile market will rotate Friday through Monday at the four locations until Sept. 7.
White, 28, lives nearby in the Luna Park section of West Seattle and takes the bus to a Safeway at Jefferson Park. Just 5 feet 2 inches tall, White said she lost 40 pounds last summer by eating only vegetables and other raw foods. She wants to lose 40 more pounds.
But currently unemployed, White said she got off the diet because it was much more expensive than subsisting on fast foods.
A visit to Delridge Neighborhoods Development Association sparked White's interest in bringing produce to residents whose nearest sources of groceries were minimarts selling chicken strips and hot wings.
"People have trouble finding cheap, organic produce," White, 28 said. "But you can get burritos and stuff."
Ranette Iding, a Delridge resident and a former school psychologist, joined White's cause. They raised additional private money, recruited volunteers and solicited donated produce, including apples, plums and cherries from Seattle's Tiny's Organic.
Part of the city's grant pays for teaching youths about healthful eating. Two teens, Davonte Thornton, 17, and Michael Oakley, 18, were getting paid to work at the produce stand.
Thornton, a senior at Cleveland High School who plans to become an obstetrician, said he eats peas, green beans and even squash but was unfamiliar with some of the produce he was peddling.
He and Oakley thought that a slender, tapered daikon was a white carrot (indeed it bore little resemblance to the more common fat tubers sold in Asian markets). They debated whether another vegetable was a squash or a cucumber before Oakley triumphantly called out, "It's a zucchini!"
Iding said no one until now has tapped Delridge residents' desire for healthful food offerings. Iding shops at PCC, the organic food emporium. But many of her neighbors lack transportation or have limited budgets.
The co-op's ultimate goal for Delridge, Iding said, is something any neighborhood should welcome — a nearby store selling organic produce at affordable prices.
Kyung Song: 206-464-2423 or email@example.com


text:
Capitalizing on
Technological Advances
|Iris, aged 59, cares for her 85-year-old mother in a rural community. Although Iris likes the idea of attending educational and support programs for dementia caregivers, she lives an hour away from the nearest caregiver support group. Because Iris finds it difficult to arrange for someone to be with her mother and doesn't like traveling when the weather is bad, she attends caregiver programs only rarely.
|John, 62, is employed and rushes home at lunchtime every day to check on his wife who is in the early stages of Alzheimer's. He knows that he should be learning more about the disease and making plans, but his evenings and weekends involve being with his wife and taking care of basic household tasks. He also feels guilty leaving his wife alone in the evening to attend educational programs, since they spend so much time away from each other during the day. He wishes there were easier ways to access information and support without having to leave his home.
|Wilma, who is 79, cares for her husband who was diagnosed with Alzheimer's disease 5 years ago. Her daughter lives nearby and helps with things like shopping and doctor's visits, but Wilma worries about asking her to help out more because her daughter also works full-time and has her own family. Wilma


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not able to access drug so is there a substitute
What is a possible substitute for benztropine?
- Posted:
- 18 Aug 2012 by tuff tuff tony
- Topics:
- benztropine
Answers (2)
10 Feb 2013
i started taking benztropine on 2/5/13 i am on .05 since then i have gone
up to .01 starting today. i will try taking .01 tonight, hopefully trying this
will help with some change. so far no change. i am suffering from td for
3 months now. i have involuntary mouth movements. not a day 24/7 for
the last 3 months have i had any relief. my dr. prescribed medication but
from what i have read benztropine does not help with td.. i can only hope that there will be an answer when i get
through to my dr. hopefully tomorrow. sorry i don't have an
answer that can help
you. i will be happy to keep you updated as i continue on this journey.
best wishes.
Further Information
- Benztropine Information for Consumers
- Benztropine Information for Healthcare Professionals (includes dosage details)
- Side Effects of Benztropine (detailed)
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What is the other names they use for Benztropine 832 BM2 2 mg tablets?
1 answer • 9 Feb 2010
My grandson is on benztropine 1 mg 2x daily. He has no medical insurance and the cost is?
... prohibitive. Is there a way of getting this med for a lesser $$ amount?
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Can Benztropine cause you to pass out and not remember that you did?
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Will benztropine show positive on drug test?
my fiance accidently took 2 of my benztropine while half asllep n middle of night instead of his med from pain dr..will my benztropine show up on ...
2 answers • 6 Feb 2012
Can seroquel XR 50 mg. be taken with 1 mg. of benztropine?
I just got put on Seroquel XR for my mood stabilizer. I was on Abilify and Strattera but it gave me acasthesia. So I am wondering if the seroquel and ...
1 answer • 21 Apr 2016


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Police seek vehicle in hit and runAugust 06,2014Police seek SUV
in hit-and-run crash
Vermont State Police are seeking information about a black SUV whose driver allegedly fled after a head-on collision Tuesday at the intersection of the East Pittsford Road and Route 7 in Rutland Town.
No one was hurt, but police said the SUV caused major damage to a Ford F-250 truck driven by Sandra Griffin, 62, of Pittsford.
Witnesses told police that the SUV was traveling south on Route 7 at about 3 p.m. Tuesday when it cut across lanes and collided with the truck. Two other vehicles were narrowly missed, police said.
The SUV drove off the road after the crash, backed up and continued south on the highway toward Rutland with moderate damage to its front end.
Anyone with information about the crash is asked to call state police at 773-9101.MORE IN This Just InMONTPELIER The races might be new, but many of the faces are the same. Full StoryRutland Town officials want to ensure businesses pay the towns 1 percent sales tax. Full StoryThe sole Democrat in the Rutland City delegation is not seeking another term.
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A different thread started by Lucille on her Bike Friday tour of france, folks started chipping in their packing and luggage tips for touring on folding/small wheel bikes. I am hoping we can start a dedicated thread for sharing all small wheel/folding touring experience and knowledge - not just luggage and packing, but any aspect. Who knows, one day it may even be grown up enough to be a sticky
This is cut from Lucille's thread, to start:


text:
About Contact Join Donate
Start here before searching The Newman Guide... - Order the Guide - Recruit Me
Students learn Italian during this first cycle and usually continue toward a Vatican-approved licentiate degree (after about five years) or a doctoral degree (after about eight years and a dissertation). There is also an English-language graduate-level program in ecumenism and interreligious dialogue.
The tuition price for the STB degree is a bargain relative to American colleges: about €2,000 for each year. There are additional fees that may apply. Food and housing are relatively expensive and arranged independently by the student, although the university's student affairs office will make recommendations for housing.


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Literally that is, guess what happens next.
How do they come up with that shit.
Did not work as planned I guess.
Poor people are always the ones paying, pedestrians, bikes, wheelchairs you name it.
I bet that seat smells great now.
WTF mate, she did not eve flinch.
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ATLANTA -- Nothing in life is guaranteed, but Clayton Kershaw with a big early lead is about as bankable as it gets.
The Los Angeles Dodgers' ace has had more efficient outings, but he got stronger as the game progressed in a 6-1 win over the Atlanta Braves in Game 1 of the National League Division Series on Thursday night. The Dodgers scored four runs in the first three innings against Kris Medlen to put Kershaw on high ground, and he had little trouble holding it.
By the end, the strikeout-prone Braves were overmatched. Kershaw struck out nine of the last 11 batters he faced. All told, he had 12 strikeouts over seven innings, giving up only three hits and three walks.
The Dodgers could take a commanding lead in the series with a win here Friday and they'll send the right-handed portion of their two-ace tandem, Zack Greinke, to the mound. Since December, Dodgers fans have fantasized about a Kershaw-Greinke hammer in October.
Kershaw needed 124 pitches, which casts some doubt on his availability to pitch Game 4 on short rest if the Dodgers are considering that plan.
The Dodgers didn't get off to a promising start against Medlen, who had made some confident statements about the Braves' chances during his Wednesday afternoon news conference. Medlen looked as though he would back it up early. He struck out the first three batters he faced, Carl Crawford, Mark Ellis and Hanley Ramirez.
Many people thought Yasiel Puig could be a liability in the playoffs because of the chance he'd make one poor decision at a bad time -- and he still might -- but he sparked the offense Thursday. This time, Puig forced the opponent to make mistakes.
Puig eked a grounder into center field for a hit and, when Juan Uribe singled to center, Puig ran hard for third, apparently taking center fielder Jason Heyward by surprise. Heyward never even attempted a throw.
Puig scored two batters later on Skip Schumaker's sacrifice fly. Heyward made an ill-advised throw to the plate, the ball sailing over the cutoff man, and Uribe took second. He scored on A.J. Ellis' double off the glove of left fielder Evan Gattis, who played the ball like the catcher he is.
Medlen hit Puig with his final pitch of the night in the fifth inning. Puig took a step or two toward the mound, but took his base without incident. Puig seems to get out of his game at times when he gets angry. In his next at-bat, against hard-throwing Jordan Walden, Puig swung and missed at a slider six inches outside and then struck out on a nose-high fastball.
The Dodgers kept adding on, making life easy for Kershaw for once. He had the lowest run support among Dodgers starters. Oh, and the Braves kept making mistakes. In the second, Crawford lined a sharp grounder to second baseman Elliot Johnson, who misplayed it into an infield hit and, after Crawford advanced on Mark Ellis' groundout, Adrian Gonzalez jumped on a first-pitch changeup and sent it sailing over the center-field wall.
It was Gonzalez's first postseason home run, though he's competing in only his second playoff series.


text:
- Differential Diagnosis
- Diseases
- Drugs
- More
- Try building your search one term at a time, and be as specific as you can! Search term example: "chronic cough".
- Do not enter multiple findings such as "anemia, chronic cough, weight loss, vomiting" all at the same time.
- After selecting your term from the search results a list of possible diagnoses will be generated. If the list is too long, you will be able to narrow it down by entering additional terms.
- Do not enter values such as "heart rhythm 110" or "sodium 125", instead use "tachycardia" or "hyponatremia".
- Disease Information
- Disease Comparison
Disease Processes ▼
- Auto Immune
- Vascular-Arteriosclerosis
- Biochemical
- Congenital-developmental
- Deficiency
- Degenrative-Necrosis
- Electromagnetic-Physics
- Eponymic
- Functional-Physiologic
- Hereditofamilial
- Iatrogenic
- Idiopathic
- Infected Organ-Abcess
- Infectious agent
- Inflammatory-Granulomatous
- Metabolic-Storage
- Neoplastic
- Poison Agent
- Poisoned Organ
- Radiation-Xray-trauma
- Mental
- Structural-Anatomic-Foreign body
- Surgical Procedure-Complication
- Trauma
- Use-age-Atrophic
- Endocrine-Vegetative
Major Organs-Systems ▼
- Systemic
- Pediatric
- Nervous & Sensory System (Neurology)
- Cardiovascular System
- Respiratory (Pulmonary) System
- Gastro-Intestinal (Digestive) System
- Urinary System
- Dermatologic System
- Endocrine System
- Immune System
- Musculoskeletal System
- Genital Reproductive System
- Hematopoietic System (Hematology)
- Lymphatic System
- Tissue/Cells/Organelles
Disease Information for VLCHAD/Very Long chain OH-CoA dehydrogenase def
Available only to registered users.
- Suggest
- 87 possible findings found
- Clinical Manifestations
- Signs & Symptoms
- Hyperextensable Joints Infant
- Anorexia in Infant
- Failure to Thrive
- Failure to Thrive Child
- Failure to thrive/infant sign
- Fasting intolerant
- Feeding/Apetite Problems Child
- Tongue Protrudes Infant
- Delay Sitting Unsupported Infant
- Hypotonia
- Mouth Hangs Open Infant
- Muscles Soft/Doughy Infant
- Rolling Over Delay Infant
- Babkin infant sign/Abnormal
- Delayed speech/language development
- Delayed walking milestone/child
- Development Motor Skills (Milestones) Delayed
- Developmental milestones delayed
- Galant Infant reflex/Abnormal
- Head Neck Floppy Infant Hypotonia Sign
- Infant Head Support Delay
- Moro reflex Poor/Absent Infant
- Palmar Grasp infant Reflex Abnormal
- Primitive infant reflexes/Abnormal
- Rooting infant sign/Abnormal
- Slow Motor Development
- Swimming infant reflex/Abnormal
- Tonic Neck Infant reflex/Abnormal
- Shallow Breathing Infant
- Episodic symptoms/events
- Near death experience/infant/SIDS survivor
- Spells/Episodes of weakness
- Sudden death of an infant
- Clinical Presentation & Variations
- Presentation/Non diabetic Ketoacidosis Kids infants
- Presentation/Maternal Difficulty Caused by Fetus Metabolism
- Disease Progression
- Course/Chronic disorder
- Course/Chronic only
- Demographics & Risk Factors
- Population Group
- Child
- Infant
- Population/Pediatrics population
- Family History
- Family history/Enzyme defect
- Family history/Metabolic disease
- Sex & Age Groups
- Population/Child
- Population/Child-Infant Only
- Population/Children/all
- Population/Infant
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Cultured fibroblast enzyme assay abnormal (Lab)
- DNATest specific/genetics laboratory/abnormality (Lab)
- Enzyme Assay plasma/tissue/fibroblast abnormal
- Fasting hypoglycemia (Lab)
- Hypoketotic hypoglycemia (Lab)
- Neonatal metabolic screening (mass spec) abnormal
- Newborn screening tests abnormal (extended)
- Abnormal Lab Findings - Decreased
- Glucose, blood (Lab)
- Abnormal Lab Findings - Increased
- pH, arterial blood (Lab)
- Diagnostic Test Results
- Other Tests & Procedures
- Amniocentesis/Chorion villi enzyme assay/abnormal
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Acidosis
- Acidosis, metabolic
- Cardiomyopathy
- Fatty acid oxidation/Metabolic syndromes
- Fatty liver of pregnancy
- Hypoglycemia, infantile
- Neonatal Hypotonia/Floppy Baby Syndrome
- Sudden death/Child
- Disease Synergy - Causes
- Synergy/Fasting/starvation
- Disease Mechanism & Classification
- Class
- CLASS/Pediatric disorders (ex)
- Pathophysiology
- Pathophysiology/Beta oxidation fat defct variant
- Pathophysiology/Fails to metabolize fat/mitochondrial level
- Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
- Pathophysiology/Intractable neonatal hypoglycemia
- Pathophysiology/Long chain 3-Hydroxyacl-CoA dehydrogenase defic
- Pathophysiology/Beta-oxidation cycle defect
- Process
- PROCESS/Autosomal recessive disorder (ex)
- PROCESS/Enzyme defect/Metabolic disorder (ex)
- PROCESS/Fatty acid Oxidation Disorders (FOD)
- PROCESS/Hereditary mitochondrial disorder (ex)
- PROCESS/Hereditofamilial (category)
- PROCESS/INCIDENCE/Esoteric disease (example)
- PROCESS/INCIDENCE/Extremely rare disease
- PROCESS/Metabolic/storage disorder (category)
- PROCESS/Mitochondrial disorders (ex)
- Synonyms
- Synonym
- VLCHAD Very Long chain OH CoA dehydrogenase def, Synonym/Fat beta oxidation mitochodrial defct variant
- Treatment
- Other Treatments
- TX/Diet restriction treatment.
- Other Treatments
- TX/Diet restriction treatment.
- TX/Frequent feedings/Avoid fasting
- TX/High carbohydrate diet
- TX/Medium chain TGA/fatty acid diet
- TX/Restricted long chain fatty acid diet
- Definition
Very long chain hydroxy-CoA dehydrogenase deficiency is essentially like long chain disease but more rare;
Long chain 3-Hydroxacyl-CoA dehydrogenase Deficiency metabolic enzyme defect; Hereditary extremely rare mitochondrial defect in all body cells; Severe fat dietary
restriction is indicated; Presentation often as failure to thrive infants; Family history positive;---------------------------------.Very Long Chain Acyl CoA Dehydrogenase Deficiency (LCAD)
LCAD Deficiency
Long Chain Acyl-CoA Dehydrogenase Deficiency
Nonketotic Hypoglycemia Caused by Deficiency of Acyl-CoA Dehydrogenase
Disorder Subdivisions
General Discussion
Very long-chain acyl-CoA dehydrogenase deficiency (VLCAD) is a rare genetic disorder of fatty acid metabolism that is transmitted as an autosomal recessive trait. It occurs when an enzyme needed to break down certain very long-chain fatty acids is missing or not working properly. VLCAD is one of the metabolic diseases known as fatty acid oxidation (FOD) diseases. In the past, the name long-chain acyl-CoA dehydrogenase deficiency (LCAD) was applied to one such disease, but today it is believed that all cases once thought to be LCAD are actually VLCAD.
The breakdown of fatty acids takes place in the mitochondria found in each cell. The mitochondria are small, well-defined bodies that are found in the cytoplasm of cells and in which the body generates energy from the breakdown of complex substances into simpler ones (mitochondrial oxidation); There appear to be two forms of VLCAD: an early-onset, severe form which, if unrecognized and undiagnosed, may lead to extreme weakness of the heart muscles (cardiomyopathy) and may be life-threatening (VLCAD-C), and a later-onset, milder form, sometimes referred to as VLCAD-H, that is characterized by repeated bouts of low blood sugar (hypoglycemia); Since the advent of expanded newborn screening programs using tandem mass spectrometry technology, more VLCAD infants are being detected earlier in the course of the disorder than in the past;[NORD 2005]
- External Links Related to VLCHAD/Very Long chain OH-CoA dehydrogenase def
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)


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The final three words on Lee Corso's work phone voice mail are "life is good." Actually, it's gooood, Corso's throaty delivery emphasizing that sometimes just waking up in the morning makes it so.
"I believe that. Life is very good," said Corso, the former Indiana University football coach who since 1987 has brought a measure of lightheartedness to college football as the amusing foil on ESPN's hugely popular "College GameDay," which airs from a different campus each week. "I've got my health, I've got my family, and I've got my faith in God.
"That is all I need. That's it."
It can be debated now and long after the 77-year-old Floridian is gone that no one lands on his feet quite like Corso, the unofficial embodiment of glass half-full.
Upon being fired at IU in 1982 after producing far more unforgettable postgame quotes — of Nebraska All-American tight end Junior Miller after the Hoosiers' 69-17 home loss to the Cornhuskers in 1978, "I'd hate to see Senior Miller" — than victories (41), Corso exited the coaching ranks for a year before becoming head coach at Northern Illinois University.
Then it was off to the United States Football League for one largely unproductive season as head coach of the Orlando Renegades. The team and the league folded shortly thereafter, which left Corso, a married father of four, standing at a career crossroads at age 50.
Always the opinionated performer, Corso made his way onto the "College GameDay" set with show host Tim Brando and Beano Cook. Filmed in a studio, those were far more subdued GameDay episodes than what we're now accustomed to.
Changes were on the horizon, when a 27-year-old Chris Fowler took over as host in 1989, and the network gradually moved more and more of the broadcast outdoors to college campuses in 1993, complete with sign-wielding fans and cheerleaders.
Former Ohio State quarterback Kirk Herbstreit joined the set in 1996 as the network's lead analyst for college football, a move that helped birth Corso's tradition of slipping on the helmet or mascot head of the team he believes will win that day's big game.
Legend has it Corso used Herbstreit's connections to retrieve the exaggerated head of Ohio State mascot Brutus Buckeye for his show-closing prediction segment one day in Columbus. Since then, Corso has covered his graying hair with everything from LSU's Tiger to a miniaturized version of Oklahoma's Sooner Schooner to Oregon's Duck, and so much more.
The man who once had a photo taken of the scoreboard after one of his IU teams jumped out to a 7-0 lead on mighty Ohio State (only to lose by a lopsided margin) celebrated his 200th headgear fitting in 2011 at a game at Michigan State.
Predictably, Corso has been cheered wildly and booed lustily. He's been called pretty much everything in the book and comes back the following Saturday as enthusiastic as ever about the college football industry and his role in it. This grandfather of 10 (including 2½-year-old triplet boys) understands the degree of passion fans have for their favorite team and takes it all in stride.
He's not out to offend but entertain. All in the name of a sport and network he loves.
What follows is a question-and-answer interview with Corso, a college roommate of actor Burt Reynolds in their playing days at Florida State University.
What is the most uncomfortable GameDay mascot headwear?
The Florida Gator. I love Florida State, and sometimes I have to put the Gator on, but I still do the Florida State chop, and that drives them crazy. I have to show them that I wear my loyalty on my sleeve.
DJ: Does celebrity ever get old?
LC: No. You're just nice to everybody. It's not hard at all. I got that from my mother and father. They were great people. My father, Alex, came over here from Italy at 15-years-old and worked as a coal miner. He had a second-grade education and my mother (Erma) had a fifth-grade education.
DJ: You and Bob Knight were on the Indiana University campus together a total of 10 years (1973-82). Your thoughts on him and when was the last time you spoke to him?
LC: I enjoyed every minute. He's the greatest teacher of basketball ever to coach. We had him on the (GameDay) set at Texas Tech a few years ago, and he was great. Away from the cameras we talk about our families, how they're doing and how proud we are of them.
DJ: Is there a campus you don't like to visit?
LC: Purdue. You have to remember that for 10 years I was involved in the (Old Oaken) Bucket game. The first time we beat Purdue in West Lafayette (in 1976) I said, "Where's the bucket?" and the guy from Purdue said, "We don't know where it is. You haven't won it here in 14 years." The next day I sent one of our assistant coaches, Phil Dickens, up there to get it. I slept with it that night. I loved it.
DJ: Were you aware one of your Internet biography pages lists you as being born in 1910 and being 103-years old?
LC: (Laughs) No. Maybe that was me in an earlier life.
DJ: Whatever became of the red pants, red sweatshirt combination you would wear during games?
LC: I still have them in a place in my den. I wouldn't get rid of that stuff for nothing. I still have replicas of the four I's from the bucket games and all of the Holiday Bowl stuff.
DJ: Your best IU memory?
LC: At the (1979) Holiday Bowl we were a four- or five-touchdown underdog and were given no chance. (Brigham Young) was undefeated and ranked eighth in the nation. We played unbelievably well, and they played unbelievably well. Their guy missed a field goal. Before he kicked it, I told Father Jim Higgins, "Father, it's you against 8 million Mormons." He missed the field goal, and they carried both of us off the field.
DJ: Did you like the hire of Kevin Wilson at IU?
LC: I don't know Kevin, but I was really disappointed that Bill Lynch wasn't there anymore.
DJ: Use one word to describe your three GameDay cohorts?
LC: Chris Fowler, professional. Kirk Herbstreit, handsome. Desmond Howard, Heisman.
DJ: The worst thing a GameDay spectator ever said to you?
LC: No comment.
DJ: Where was it?
LC: No comment. I cannot repeat them.
DJ: Do you have quiet time? If so, how is it spent?
LC: I fish. I have a lake in my back yard. Lake Corso (laughs). I fish bass with my best friend, Ed Fasula, who taught me how to fish. I catch and release. You don't eat them or you would glow at night. You throw them back in.
DJ: Are you better at this job or as a football coach?
LC: Obviously, I'm better now. Now it all depends on me. Remember, I coached football at Louisville and Indiana, two of the best basketball schools in the country.
DJ: ESPN just extended your contract to include the 2013 and '14 seasons. Would you like to do "College GameDay" beyond that?
LC: Oh, sure. I've got a great job. I want to do it as long as I'm capable. And I'm especially proud that I've been with one network my entire career.


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Kansas City police are investigating after a man was found shot to death in the driveway of a home near 77th Street and Brooklyn Avenue early Friday morning.
Police said they were called to the 1800 block of East 77th Street just after midnight on reported shots fired.
When officers arrived, they found a man in his 30s dead in the driveway.
No arrests have been made.
Anyone with information on the shooting is asked to call the TIPS Hotline at 816-474-8477.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Tim Gane
The personal site of Tim Gane, a web developer, communications professional, Brazilian Jiu Jitsu Practitioner
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In Search of New England's Classic Cocktail
Also, the Ward 8 commits the sin of not being very local. You might as well insist that Boston's official bean dish is "black beans with mango." When was the last time you spent an afternoon at a lemon or orange grove in New England? All of the Ward 8's ingredients are imported. Does that reflect a proud New England spirit? It does not.
History may provide limited guidance on the quintessential New England cocktail, but it's like trying to track down Moby Dick based on a 150-year-old book. If I were going to find this white whale, I'd have to track down my own ingredients, and assemble a quintessential New England cocktail myself.
Today, anything that claims to represent a region must consist wholly of ingredients from that region. A classic cocktail typically includes a base spirit, plus a modifier, a sweetener, and maybe a dash or two of something extra. All would have to be local.
I asked Jackson Cannon (whose name suddenly sounded like something out of Melville to me) what spirit he would choose for a contemporary New England classic. He drummed his fingers a bit on the bar and said, "Well, we've become disconnected from our rum roots." But then he ordered up for me a "Red Maple," made with an old-fashioned navy-proof rum called Smith & Cross ("like a Medford overproof") and maple syrup, plus grapefruit juice and bitters. It was a sturdy, delicious cocktail, with the taste of wood and sap. Rum it would be.
Then Cannon showed me a simple, apothecary-style rum bottle with a yellow label featuring a silhouette of a horse. I looked more closely. "Handmade in Boston," it said.
Will Willis, the tall, young, tousled- and sandy-haired co-owner of Bully Boy Distillers in Boston, was in the middle of a sentence when he held up his finger in the international "Hold that thought" gesture. He then dashed into an adjacent room housing his burbling still. Curious, I followed. A clear, aromatic fluid spewed erratically out of a pipe attached to a tall column, overshooting a glass jar set atop an upended spackle bucket and pooling on the concrete floor. Willis repositioned the jar so as to catch the newly unleashed freshet, then resumed his thought.
There's an essentially steampunkish feel to a distillery: gauges, small portholes through which something murky and frothy is violently agitated, the friendly and burnished-brown feel of the copper, the sudden smell of something solvent-like. A distillery remains a remarkable thing: a heady mix of past and present.
Willis and his brother Dave, his partner in the distillery, are the first to make rum in Boston in about five decades. (They've recently been joined by GrandTen in Southie, and at least one other aspiring distiller is looking to revive the Boston rum trade.) They're not the first modern rum makers in New England, though. Triple Eight has been making rum on Nantucket for about 10 years, and a number of entrepreneurs have jumped in since then: Ryan & Wood (Folly Cove) in Gloucester, Berkshire Mountain (Ragged Mountain) in Great Barrington, Privateer Rum in Ipswich, Newport Distilling (Thomas Tew) in Rhode Island, and several others.
This is as it should be. New England had well over a hundred rum distilleries on the eve of the American Revolution. Clever colonists understood that West Indian molasses could be had cheaply and in limitless quantity; it arrived as part of a complicated web of transactions that sometimes included slaves. But New England could eat only so much gingerbread and baked beans. So enterprising sorts set up distilleries along these chilly shores to turn a treacly, dark byproduct of sugar processing into liquid gold. The rum industry thrived until Prohibition, and then had trouble regaining its footing after Repeal. By the middle of the last century, rum was more associated with Caribbean Island vacations than with wintry New England.
"I've been fascinated by rum since I was 15," Willis said, adding that his fascination might have resulted from sneaking sips of his parents' rum-and-tonics. After college he went into real-estate development for a while, but in long discussions with his brother, a lawyer, they decided they wanted to make something tangible. Also, they were in their thirties and figured that if it failed, they'd still have time to pick up the pieces and move on to something else.
After some experiments with stovetop distilling, they leased an old storage building on an industrial edge of Boston, went through the year-long process of getting the proper permits and licenses, bought a lovely new Ulrich Kothe still, and came up with a name. ("Bully Boy" was their great-grandfather's horse. "He was a big Teddy Roosevelt fan," Willis noted.) In addition to rum, they also make vodka and whiskey and are experimenting with liqueurs.
Part of the distillery is cluttered with blue plastic totes the size of Jacuzzis, filled with molasses shipped from Louisiana; it will soon be fermented and run through the still. Some of what emerges will be put away in used wine casks to age for a couple of years; the rest is marketed as their ethereal dry white rum, touched with transcendent notes of molasses and caramel–a product that goes more or less directly into bottles without a detour through a barrel. "It's a mixing spirit," Willis added.
It also happens to be quite delicious. I put a bottle in the back seat.
I sampled another memorable New England rum a week later and five hours up the coast, at Spirits of Maine Distillery in the small coastal town of Gouldsboro. Bob Bartlett, who got his start making award-winning blueberry and apple wines three decades ago (at his Bartlett Maine Estate Winery), ordered a state-of-the-art still in 2007 and started messing around with fermented fruits and more. His rum is made from molasses imported from the islands, which is then aged in new French oak barrels, the sort more commonly used for wine. (Most rum makers age their product in used bourbon barrels, which Bartlett considers "flavoring" the spirit. "To me it's a sin," he said.)
At the time of my visit, Bartlett hadn't started bottling his rum yet, but it had been aging close to two years, so he popped open the bung and stuck in his "thief"–a narrow glass tube designed for barrel sampling. I sipped. It was a light, delicate rum, dry yet edged with the robust flavor of molasses.


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I've got a Maxtor Shared Storage II (RAID1 mode) which has developed some hardware failure, apparently: it fails to boot properly and is unreachable via network.
When powering it on, it keeps making clunking/chirping disk noise and then sort of resets itself (with a flash of orange light in the usually-green LEDs); it then repeats this as if stuck in a loop. In fact, even the power button does nothing now – the only way I can affect the device at all is to plug in or pull out the power cord!
(To be clear, I've come to regard this piece of garbage (which cost about 460 €) as my worst tech purchase ever. Even before this failure I had encountered many annoyances about the drive: 1) the software to manage it is rather crappy; 2) it is way noisier that what this type of device should be; 3) when your Mac comes out of sleep, Maxtor's "EasyManage" cannot re-mount the drive automatically.)
Anyway, the question at hand is how to get my data out of it? As a very concrete first step, is there a way to open this thing without breaking the plastic casing into pieces? It is far from obvious to me how to get beyond this stage:
It opens a little from one end but not from the other:
If I somehow got the disks out, I could try mounting the disk(s) on one of the Macs or Linux boxes I have available (although I don't know yet if I'd need some adapters for that).
(NB: for the purposes of this question, never mind any warranty or replacement issues – that's secondary to recovering the data.)


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State expert finds clues to save lives
An Oklahoma Medical Research Foundation scientist's work may explain why lupus occurs more in women. Dr. Amr Sawalha discovered a gene on the X chromosome that likely plays a role in the autoimmune disorder. Women carry two X chromosomes but men carry only one. Women develop lupus nine times more than men. Chromosomes are long pieces of DNA found in cells. Humans have 23 pairs. "This is the first gene to be related to adult (onset) lupus on the X chromosome," Sawalha said, adding that he hopes the finding helps researchers understand why lupus is more common in women. The gene Sawalha studied, , plays a role in controlling many other genes, and a mutation in it likely predisposes a person to lupus. If the gene is unable to do its job, as in lupus patients, immune system T cells become overactive, resulting in the immune system turning on the body. "Basically, it makes the T cells abnormally active — hyperactive," Sawalha said. Sawalha's findings appeared last month in the journal Plos One. The gene's discovery could lead to new therapies for lupus. Some 2 million Americans and 15 million people worldwide have the disease. Sawalha also is an assistant professor of medicine at the University of Oklahoma Health Sciences Center and a staff physician with the Veteran's Administration Hospital in Oklahoma City. Lupus can affect multiple organs, joints and skin. It can be life-threatening and has no cure. Patients are treated with drugs that suppress their immune systems. Researchers long have suspected the X chromosome played an important role in lupus, according to the report. Men who have Klinefelter's syndrome, in which they have an extra X chromosome, have a lupus risk similar to women's. Because lupus' causes are unknown, Sawalha and others are focusing on identifying genes that are more often seen in lupus patients than in those who don't have the disease.
More steps aheadHe said lupus likely is "polygenic," meaning it is caused by two or more genes, and has environmental triggers as well. The next step, he said, will be to study the mutated gene's chemical sequence to potentially treat or diagnose lupus. "We want to know exactly where it is and what it will do," he said. Fellow OMRF lupus researcher Dr. John Harley and an international consortium in January identified 13 genes they think contribute to lupus. OMRF is home to the Lupus Family Registry and Repository, a collection of blood samples from lupus patients and family members without lupus. By studying the differences among closely related donors, researchers seek to determine which genes predispose a person to developing lupus. Samples from the repository were used in Sawalha's study. OMRF President Dr. Stephen Prescottcommended the foundation that Sawalha's work lays. "Sometimes understanding the basics of a disease is the key to finding more effective treatments," Prescott said of the recent findings.
Lupus discoveryDr. Amr Sawalha has found a gene on the X chromosome that likely plays a role in lupus. Lupus causes the immune system to fight the body. Researchers don't know what causes lupus, but it occurs far more in women. Sawalha's findings coupled with the fact that women have two X chromosomes may explain why women are more likely to suffer from the disease.
About lupusNo cure or definitive test exists. Lupus symptoms can range from mild to life threatening, and include: •Aching joints, arthritis •Anemia •Sensitivity to light •Hair loss •Painless ulcers in the nose or mouth •Atypical blood clotting •Facial rashes •Frequent fevers higher than 100 degrees Source: Lupus Foundation


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We want to help you get it right the first time! Enjoy the convenience of ordering online or by phone from our huge selection of over 5,000 container products. We'll work hard for your continuing satisfaction. If you have questions, you can do live chat on our website with our highly trained Customer Service Experts or call them at 1.800.776.3786.
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Beekeeping is buzzing in Utah
Honeybees are among the most fascinating creatures in the world. On a typical summer day, each will travel over three miles... read full article.


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Carpenters construct and repair building frameworks and structuressuch as stairways, doorframes, partitions, and raftersmade from wood and other materials. They also may install kitchen cabinets, siding, and drywall. Show Details
Carpenters typically do the following:
Carpenters are one of the most versatile construction occupations, with workers usually doing a variety of tasks. For example, some carpenters insulate office buildings; others install drywall or kitchen cabinets in homes. Those who help construct large buildings or bridges often make the wooden concrete forms for cement footings or pillars. Some carpenters build braces and scaffolding for buildings.
Carpenters use many different hand and power tools to cut and shape wood, plastic, fiberglass, or drywall. They commonly use handtools, including squares, levels, and chisels, as well as many power tools, such as sanders, circular saws, and nail guns. Carpenters put materials together with nails, screws, staples, and adhesives, and do a final check of their work to ensure accuracy. They use a tape measure on every project because proper measuring increases productivity, reduces waste, and ensures that the pieces being cut are the proper size.
The following are types of carpenters:
Residential carpenters typically specialize in new-home, townhome, and condominium building and remodeling. As part of a single job, they might build and set forms for footings, walls and slabs, and frame and finish exterior walls, roofs, and decks. They frame interior walls, build stairs, and install drywall, crown molding, doors, and kitchen cabinets. Highly-skilled carpenters may also tile floors and lay wood floors and carpet. Fully-trained construction carpenters are easily able to switch from new-home building to remodeling.
Commercial carpenters typically remodel and help build commercial office buildings, hospitals, hotels, schools, and shopping malls. Some specialize in working with light gauge and load-bearing steel framing for interior partitions, exterior framing, and curtain wall construction. Others specialize in working with concrete forming systems and finishing interior and exterior walls, partitions, and ceilings. Highly skilled carpenters can usually do many of the same tasks as residential carpenters.
Industrial carpenters typically work in civil and industrial settings where they put up scaffolding and build and set forms for pouring concrete. Some industrial carpenters build tunnel bracing or partitions in underground passageways and mines to control the circulation of air to worksites. Others build concrete forms for tunnels, bridges, dams, power plants, or sewer construction projects.
Farmers, ranchers, and other agricultural managers run establishments that produce crops, livestock, and dairy products. Show Details
Farmers, ranchers, and other agricultural managers typically do the following:
American farmers, ranchers, and other agricultural managers produce enough food and fiber to meet the needs of the United States and for export. However, farm output and income are strongly influenced by weather, disease, fluctuations in prices, and federal farm programs.
Farmers, ranchers, and other agricultural managers monitor the constantly changing prices for their product. They use different strategies to protect themselves from unpredictable changes in the markets.
Many farmers carefully plan the combination of crops that they grow, so if the price of one crop drops, they will have enough income from another crop to make up the loss. When farmers and ranchers plan ahead, they may be able to store their crops or keep their livestock to take advantage of higher prices later in the year.
Most farm output goes to food-processing companies. However, some farmers now choose to sell their goods directly to consumers through farmer's markets or use cooperatives to reduce their financial risk and gain a larger share of the final price of their goods. In community-supported agriculture, cooperatives sell shares of a harvest to consumers before the planting season to ensure a market for the farm's produce.
Farmers, ranchers, and other agricultural managers also negotiate with banks and other credit lenders to get financing because they must buy seed, livestock, and equipment before they have products to sell.
Farmers and ranchers own and operate mainly family-owned farms. They also may lease land from a landowner and operate it as a working farm.
The size of the farm or range determines which tasks farmers and ranchers handle. Those who operate small farms or ranges usually do all tasks. In addition to growing crops and raising animals, they keep records, service machinery, and maintain buildings.
Those who operate large farms, however, have employeesincluding agricultural workers who help with physical work. Some employees of large farms are in nonfarm occupations, working as truck drivers, sales representatives, bookkeepers, and IT specialists.
Both farmers and ranchers operate machinery and maintain their equipment and facilities. They track technological improvements in animal breeding and seeds, choosing new products that might improve output.
Agricultural managers take care of the day-to-day operation of one or more farms, ranches, nurseries, timber tracts, greenhouses, or other agricultural establishments for corporations, farmers, or owners who do not live and work on their farm or ranch.
Agricultural managers usually do not do production activities themselves. Instead, they hire and supervise farm and livestock workers to do most daily production tasks.
Managers may determine budgets. They may decide how to store and transport the crops. They oversee proper maintenance of equipment and property.
The following are some types of farmers, ranchers, and other agricultural managers:
Crop farmers and managersthose who grow grain, fruits and vegetables, and other cropsare responsible for all steps of plant growth. After a harvest, they make sure that the crops are properly packaged and stored.
Livestock, dairy, and poultry farmers, ranchers, and managers feed and care for animals. They keep livestock in barns, pens, and other well-maintained farm buildings. These workers also oversee breeding and marketing.
Horticultural specialty farmers and managers oversee the production of fruits, vegetables, flowers, and plants (including turf) used for landscaping. They also grow grapes, berries, and nuts used in making wine.
Aquaculture farmers and managers raise fish and shellfish in ponds, floating net pens, raceways, or recirculating systems. They stock, feed, protect, and maintain aquatic life used for food and for recreational fishing.


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Movie theaters are back in Berkeley high-rise plans
By Emilie Raguso BERKELEYSIDE: Six state-of-the-art movie theaters have replaced a public plaza in new designs for 2211 Harold Way, Berkeley's first proposed high-rise to be developed in decades. In …
On the night of reopening, Alice Waters reaffirms Berkeley as the best place for Chez Panisse
By Tracey Taylor BERKELEYSIDE: Alice Waters admits there have been times — many times in fact — when she and the Chez Panisse team have considered relocating the world renowned restaurant. "We have …