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Publications (11)34.93 Total impact
Article: PL-100, a Novel HIV-1 Protease Inhibitor Displaying a High Genetic Barrier to Resistance: An In Vitro Selection Study[Show abstract] [Hide abstract] ABSTRACT: The development of new HIV inhibitors with distinct resistance profiles is essential in order to combat the development of multi-resistant viral strains. A drug discovery program based on the identification of compounds that are active against drug-resistant viruses has produced PL-100, a novel potent protease inhibitor (PI) that incorporates a lysine-based scaffold. A selection for resistance against PL-100 in cord blood mononuclear cells was performed, using the laboratory-adapted IIIb strain of HIV-1, and it was shown that resistance appears to develop slower against this compound than against amprenavir, which was studied as a control. Four mutations in protease (PR) were selected after 25 weeks: two flap mutations (K45R and M46I) and two novel active site mutations (T80I and P81S). Site-directed mutagenesis revealed that all four mutations were required to develop low-level resistance to PL-100, which is indicative of the high genetic barrier of the compound. Importantly, these mutations did not cause cross-resistance to currently marketed PIs. In contrast, the P81S mutation alone caused hypersensitivity to two other PIs, saquinavir (SQV) and nelfinavir (NFV). Analysis of p55Gag processing showed that a marked defect in protease activity caused by mutation P81S could only be compensated when K45R and M46I were present. These data correlated well with the replication capacity (RC) of the mutant viruses as measured by a standard viral growth assay, since only viruses containing all four mutations approached the RC of wild type virus. X-ray crystallography provided insight on the structural basis of the resistance conferred by the identified mutations.
- [Show abstract] [Hide abstract] ABSTRACT: In vivo evaluation of good manufacturing practice-grade targeted liposomal doxorubicin (TVT-DOX), bound to a CD13 isoform expressed on the vasculature of solid tumors, in human tumor xenografts of neuroblastoma, ovarian cancer, and lung cancer. Mice were implanted with lung, ovarian, or neuroblastoma tumor cells via the pulmonary, peritoneal, or orthotopic (adrenal gland) routes, respectively, and treated, at different days post inoculation, with multiple doses of doxorubicin, administered either free or encapsulated in untargeted liposomes (Caelyx) or in TVT-DOX. The effect of TVT-DOX treatment on tumor cell proliferation, viability, apoptosis, and angiogenesis was studied by immunohistochemical analyses of neoplastic tissues and using the chick embryo chorioallantoic membrane assay. Compared with the three control groups (no doxorubicin, free doxorubicin, or Caelyx), statistically significant improvements in survival was seen in all three animal models following treatment with 5 mg/kg (maximum tolerated dose) of TVT-DOX, with long-term survivors occurring in the neuroblastoma group; increased survival was also seen at a dose of 1.7 mg/kg in mice bearing neuroblastoma or ovarian cancer. Minimal residual disease after surgical removal of neuroblastoma primary mass, and the enhanced response to TVT-DOX, was visualized and quantified by bioluminescence imaging and with magnetic resonance imaging. When treated with TVT-DOX, compared with Caelyx, all three tumor models, as assayed by immunohistochemistry and chorioallantoic membrane, showed statistically significant reductions in cell proliferation, blood vessel density, and microvessel area, showing increased cell apoptosis. TVT-DOX should be evaluated as a novel angiostatic strategy for adjuvant therapy of solid tumors.
Article: Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects[Show abstract] [Hide abstract] ABSTRACT: In an effort to develop new agents and molecular targets for the treatment of cancer, aspargine-glycine-arginine (NGR)-targeted liposomal doxorubicin (TVT-DOX) is being studied. The NGR peptide on the surface of liposomal doxorubicin (DOX) targets an aminopeptidase N (CD13) isoform, specific to the tumor neovasculature, making it a promising strategy. To further understand the molecular mechanisms of action, we investigated cell binding, kinetics of internalization as well as cytotoxicity of TVT-DOX in vitro. We demonstrate the specific binding of TVT-DOX to CD13-expressing endothelial [human umbilical vein endothelial cells (HUVEC) and Kaposi sarcoma-derived endothelial cells (SLK)] and tumor (fibrosarcoma, HT-1080) cells in vitro. Following binding, the drug was shown to internalize through the endosomal pathway, eventually leading to the localization of doxorubicin in cell nuclei. TVT-DOX showed selective toxicity toward CD13-expressing HUVEC, sparing the CD13-negative colon-cancer cells, HT-29. Additionally, the nontargeted counterpart of TVT-DOX, Caelyx, was less cytotoxic to the CD13-positive HUVECs demonstrating the advantages of NGR targeting in vitro. The antitumor activity of TVT-DOX was tested in nude mice bearing human prostate-cancer xenografts (PC3). A significant growth inhibition (up to 60%) of PC3 tumors in vivo was observed. Reduction of tumor vasculature following treatment with TVT-DOX was also apparent. We further compared the efficacies of TVT-DOX and free doxorubicin in the DOX-resistant colon-cancer model, HCT-116, and observed the more pronounced antitumor effects of the TVT-DOX formulation over free DOX. The potential utility of TVT-DOX in a variety of vascularized solid tumors is promising.
Article: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Novel Protease Inhibitor of Human Immunodeficiency Virus Type 1[Show abstract] [Hide abstract] ABSTRACT: Despite the success of highly active antiretroviral therapy, the current emergence and spread of drug-resistant variants of human immunodeficiency virus (HIV) stress the need for new inhibitors with distinct properties. We designed, produced, and screened a library of compounds based on an original l-lysine scaffold for their potentials as HIV type 1 (HIV-1) protease inhibitors (PI). One candidate compound, PL-100, emerged as a specific and noncytotoxic PI that exhibited potent inhibition of HIV-1 protease and viral replication in vitro (Ki, ∼36 pM, and 50% effective concentration [EC50], ∼16 nM, respectively). To confirm that PL-100 possessed a favorable resistance profile, we performed a cross-resistance study using a panel of 63 viral strains from PI-experienced patients selected for the presence of primary PI mutations known to confer resistance to multiple PIs now in clinical use. The results showed that PL-100 retained excellent antiviral activity against almost all of these PI-resistant viruses and that its performance in this regard was superior to those of atazanavir, amprenavir, indinavir, lopinavir, nelfinavir, and saquinavir. In almost every case, the increase in the EC50 for PL-100 observed with viruses containing multiple mutations in protease was far less than that obtained with the other drugs tested. These data underscore the potential for PL-100 to be used in the treatment of drug-resistant HIV disease and argue for its further development.
- [Show abstract] [Hide abstract] ABSTRACT: A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.
Article: Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding[Show abstract] [Hide abstract] ABSTRACT: PCK3145 is an anti-metastatic synthetic peptide with promising therapeutic efficacy against hormone-refractory prostate cancer. The characterization of the PCK3145 peptide cell surface binding/internalization mechanisms and of the receptors involved remained to be explored. [(14)C]PCK3145 cell surface binding assays showed rapid and transient kinetic profile, that was inhibited by RGD peptides, laminin, hyaluronan, and type-I collagen. RGD peptides were however unable to inhibit PCK3145 intracellular uptake. Far-Western ligand binding studies enabled the identification of the 37-kDa laminin receptor precursor (37LRP) as a potential ligand for PCK3145. Overexpression of the recombinant 37LRP indeed led to an increase in PCK3145 binding but unexpectedly not to its uptake. Our data support the implication of laminin receptors in cell surface binding and in transducing PCK3145 anti-metastatic effects, and provide a rational for targeting cancers that express high levels of such laminin receptors.
- [Show abstract] [Hide abstract] ABSTRACT: A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.
Article: Lamy S, Ruiz MT, Wisniewski J, Garde S, Rabbani SA, Panchal C et al.. A prostate secretory protein 94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: implication in tumor angiogenesis. Int J Cancer 118: 2350-2358[Show abstract] [Hide abstract] ABSTRACT: We have previously observed that the synthetic peptide corresponding to amino acids 31-45 (PCK3145) of PSP94 can reduce prostate tumor growth in vivo. Moreover, a recently concluded phase IIa clinical trial with patients with hormone refractory prostate cancer indicated that PCK3145 down-regulates the levels of plasma matrix metalloproteinase (MMP)-9, a MMP involved in metastasis and tumor angiogenesis. The purpose of our study was to investigate the molecular mechanisms of action of PCK3145 and whether this peptide could antagonize tumor neovascularization. We show that, in a syngeneic in vivo model of rat prostate cancer, the expression of endothelial cell (EC) specific CD31, a marker of tumor vessel density, was decreased by 43% in PCK3145-treated animals. In vitro, PCK3145 specifically antagonized in a dose-dependent manner the VEGF-induced ERK phosphorylation as well as the phosphorylation of the VEGFR-2 in cultured EC (HUVEC). These anti-VEGF effects were partly reproduced by pharmacological inhibitors such as PD98059 and PTK787, suggesting that PCK3145 inhibits the tyrosine kinase activity associated to VEGFR-2, which in turn prevents intracellular signalling through the MAPK cascade. Moreover, PCK3145 was also found to inhibit the PDGF-induced phosphorylation of PDGFR in smooth muscle cells. Finally, PCK3145 inhibited in vitro EC tubulogenesis and VEGF-induced MMP-2 secretion suggesting its potential implication as an antiangiogenic agent. Our study demonstrates that PCK3145 interferes with the tyrosine kinase activity associated with VEGF signalling axis in EC. The antiangiogenic properties of this peptide could be highly beneficial and exploited in novel antiangiogenic therapies, for patients with various cancers.
Article: Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling[Show abstract] [Hide abstract] ABSTRACT: PCK3145 is a synthetic peptide corresponding to amino acids 31-45 of prostate secretory protein 94 which can reduce experimental skeletal metastases and prostate tumor growth. These anti-metastatic and anti-tumoral effects of PCK3145 are partially explained by the in-vivo and in-vitro decrease in matrix metalloproteinase (MMP)-9 extracellular levels through as yet unidentified molecular mechanisms of action. Gelatin zymography and immunoblots were used to monitor the levels of secreted MMP-9 from HT-1080 cells. Flow cytometry was used to monitor HT-1080 cell surface binding of FITC-labeled PCK3145 and biotin-labeled laminin. PCK3145-coated cell culture dishes were used to monitor cell adhesion. HT-1080 cell lysates were used for immunoblotting of HuR, extracellular signal-regulated protein kinase (ERK) and phospho-ERK. Total RNA was isolated and RT-PCR used to monitor HuR gene expression. We found that PCK3145 bound to the HT-1080 cell surface and that this binding rapidly triggered ERK phosphorylation that, ultimately, led to a reduction of secreted MMP-9. Laminin inhibited both cell surface binding and ERK phosphorylation by PCK3145. Overexpression of the 67-kDa laminin receptor led to an increased binding of the cells to PCK3145. HuR, a protein that can bind to and stabilize MMP-9 mRNA, was found to be downregulated by PCK3145. The mitogen-activated protein kinase/ERK (MEK) inhibitor PD98059 as well as native laminin and SIKVAV laminin-derived peptide prevented that downregulation. Our data suggest that PCK3145 rapidly triggers intracellular signaling through cell surface laminin receptors. This leads to decreased HuR expression and subsequent destabilization of MMP-9 transcripts. This is the first molecular evidence demonstrating the intracellular signaling and anti-metastatic mechanism of action of PCK3145 that leads to the inhibition of MMP-9 secretion.
Article: Prostate secretory protein of 94 amino acids (PSP-94) and its peptide (PCK3145) as potential therapeutic modalities for prostate cancer[Show abstract] [Hide abstract] ABSTRACT: This review focuses on the promising roles of prostate secretory protein of 94 amino acids (PSP-94) and one of its derived peptides (PCK3145) as potential therapeutic modalities for prostate cancer and its associated complications. Evaluation of these compounds was carried out in vitro and in vivo using syngeneic models of rat prostate cancer. Overproduction of parathyroid hormone-related protein (PTHrP) results in the development of hypercalcemia of malignancy in several malignancies including prostate cancer. In order to evaluate the effect of PSP-94 and PCK3145 on prostate cancer progression, the rat Dunning R3227 MatLyLu cell line transfected with full-length cDNA encoding PTHrP (MatLyLu-PTHrP) was used. As the main pathogenetic factor of hypercalcemia of malignancy, overexpression of PTHrP was aimed at mimicking the hypercalcemic nature seen in patients suffering from late-stage cancer. In vitro studies showed that PSP-94 and PCK3145 can cause a dose-dependent inhibition in the growth of MatLyLu-PTHrP cells. For in vivo studies, male Copenhagen rats were inoculated either s.c. into the right flank or directly into the left ventricle via intracardiac (i.c.) inoculation with MatLyLu-PTHrP cells. In these models, s.c. injection of MatLyLu cells results in the development of primary tumor growth, whereas i.c. inoculation routinely results in the development of experimental skeletal metastases in the lumbar vertebrae causing hind-limb paralysis. Administration of PSP-94 and PCK3145 into tumor-bearing animals resulted in a dose-dependent inhibition of primary tumor growth, and tumoral and plasma PTHrP levels, and in the reduction of plasma calcium levels. Additionally, treatment with PSP-94 or PCK3145 caused an inhibition of skeletal metastases resulting in a significant delay in the development of hind-limb paralysis. Interestingly, equimolar concentrations of PCK3145 were shown to be more effective in delaying the development of experimental skeletal metastases as compared to PSP-94. One of the possible mechanisms of action of these modalities is through the induction of apoptosis which was observed by both in-vitro and in-vivo analyses of MatLyLu-PTHrP cells and tumors. Several intracellular mechanisms can also be involved in inhibiting PTHrP production and anti-tumor effects of PSP-94 and PCK3145. Collectively, these studies warrant the continued clinical development of these agents as therapeutic agents for patients with hormone-refractory prostate cancer.
Article: Annabi B, Bouzeghrane M, Currie JC, Hawkins R, Dulude H, Daigneault L et al.A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis. Clin Exp Metastasis 22:429-439[Show abstract] [Hide abstract] ABSTRACT: PCK3145 is a synthetic peptide corresponding to amino acids 31-45 of prostate secretory protein 94, which can reduce experimental skeletal metastases and prostate tumor growth in vivo. Part of its biological action involves the reduction of circulating plasma matrix metalloproteinase (MMP)-9, a crucial mediator in extracellular matrix (ECM) degradation during tumor metastasis and cancer cell invasion. The antimetastatic mechanism of action of PCK3145 is however, not understood. HT-1080 fibrosarcoma cells were treated with PCK3145, and cell lysates used for immunoblot analysis of small GTPase RhoA and membrane type (MT)1-MMP protein expression. Conditioned media was used to monitor soluble MMP-9 gelatinolytic activity by zymography and protein expression by immunoblotting. RT-PCR was used to assess RhoA, MT1-MMP, MMP-9, RECK, and CD44 gene expression. Flow cytometry was used to monitor cell surface expression of CD44 and of membrane-bound MMP-9. Cell adhesion was performed on different purified ECM proteins, while cell migration was specifically performed on hyaluronic acid (HA). We found that PCK3145 inhibited HT-1080 cell adhesion onto HA, laminin-1, and type-I collagen suggesting the common implication of the cell surface receptor CD44. In fact, PCK3145 triggered the shedding of CD44 from the cell surface into the conditioned media. PCK3145 also inhibited MMP-9 secretion and binding to the cell surface. This effect was correlated to increased RhoA and MT1-MMP gene and protein expression. Our data suggest that PCK3145 may antagonize tumor cell metastatic processes by inhibiting both MMP-9 secretion and its potential binding to its cell surface docking receptor CD44. Such mechanism may involve RhoA signaling and increase in MT1-MMP-mediated CD44 shedding. Together with its beneficial effects in clinical trials, this is the first demonstration of PCK3145 acting as a MMP secretion inhibitor.


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Sprint to Sell Samsung Tablet for $400
Sprint Nextel Corp. S 1.94 % said it plans to sell Samsung Electronics Co. Ltd.'s Galaxy Tab tablet computer for a third less than Verizon Wireless.
Sprint will sell the device for $399.99 in exchange for a two-year commitment to a data service plan. Sprint will begin selling the Galaxy Tab on Nov. 14, three days after Verizon Wireless.
Verizon Wireless said last week it would sell the device for $599.99, but offered a prepaid data plan without the requirement for a contract. Sprint will also offer the tablet for $599.99 without a contract.
For any mobile product, getting the proper marketing and subsidy support from a carrier is crucial to a successful launch. A subsidized device can dull much of the sticker shock that comes from seeing the actual retail prices. Carriers are willing to offer a discount because they can lock customers into multi-year service agreements.
Verizon Wireless's decision to sell the product without a subsidy had some industry analysts speculating that it wouldn't fare well against the iPad, which the carrier also plans to sell for as little as $629.99.
Consumers who buy the Galaxy Tab from Sprint have to sign up for a monthly $29.99 plan that includes two gigabytes of data, or a higher end $59.99 plan with a limit of five gigabytes of data.
For consumers who don't want to sign up for a contract, Sprint customers can pay $29.99 each month for 2 gigabytes of data. Verizon Wireless, in comparison, offers 1 gigabyte of data a month for $20.
Sprint plans to support the device a marketing campaign to promote the new category of tablets, according to David Owens, who is runs the carrier's marketing for product launches. "It'll be a substantial campaign and an important part of our holiday theme," he said in an interview, but the effort wouldn't be as strong as its marketing for flagship smartphones, such as its Evo 4G.
Samsung's Galaxy Tab is the electronic makers' big push in the mobile business for the holiday season. Having launched its Galaxy S line of phones on all of the major U.S. carriers, it has followed up with the Galaxy Tab. AT&T Inc. T 0.39 % and T-Mobile USA, a unit of Deutsche Telekom AG, are expected to sell the tablet as well but haven't yet announced pricing.
Samsung's entry into the market represents a chance to make up for lost ground. Product executive Hankil Yoon has said he expects the Galaxy Tab to ship 10 million units and take a third of the global tablet market this year.
The Galaxy Tab is the latest product to attempt to tap into the explosive growth of the tablet market, first sparked by Apple Inc. AAPL -0.06 % 's iPad. Many device makers, such as BlackBerry maker Research In Motion Ltd. and Hewlett-Packard Co. HPQ 1.00 % , have recently announced tablets to rival Apple's popular product.
The Galaxy Tab runs on Google Inc.'s Android software. It's smaller than the iPad, which has a 9.7-inch screen. Unlike Apple's device, it supports Adobe Flash, enabling it to show more video found on the Internet. It has a camera on each side and a slot for expandable memory, among other features.
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text: The Dirge: Three of Three wiki last edited by Saren on 07/07/13 01:01AM View full history There's a story not getting told because the media's ground to a halt. The cops are nowhere to be seen. It's a conspiracy. And the only people who can tell it are outlaw journalists Spider Jerusalem and his filthy assistants. But they may not get the chance! "Dirge" Part 3.


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You couldn't have made it without your friends. Show your gratitude with a Bright Blue Grad Personalized Thank You! Each 5" by 7" white note has a blue border with cap accent and a space for you to hand-write your message. Personalize each one with its intended's name on top! Made to match our Bright Blue Grad invites, these notes come with their own envelopes.
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Be fortified with renewed resolution and release your resourcefulness to surmount any life challenge
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Follow in the seaward trail of that persevering hero of Greek legend, Odysseus! For the man whose ingenuity captured Troy - surmounted life's most formidable obstacles to reach his own heart's dreams. Venture through the land of the lotus-eaters - islanders who welcome newcomers with a mind-altering food. For those who partake of this 'lotus flower' lose all longing for their heart's dreams - satisfied with the everyday routine of bemused comfort and ease... But resolutely focused on your dreams, deeply believed - like the hero Odysseus - you are completely immune to the plant's power. For don't you desire more than the familiar, secure routine? Don't you seek to realize what makes you feel fulfilled! To actualize your true potential!
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We invite you to also join our Facebook community or follow us on Twitter to get the most up to date news on issues affecting women's health and rights. Looking for other ways to be involved?
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09.01.15 - "I was hurting so bad I didn't know what to do with myself," remembers Tiffany,
who was forced to labor for hours in a basement hallway of the public hospital
in Jackson, Mississippi, where she had sought maternity care…
07.08.15 - The audience clusters attentively around her as she
describes a morning two years ago—taping a catheter to the inside of her thigh,
lacing up her pink running shoes, and assembling a binder of emails from
hundreds of women. …
04.09.15 - Join us on Monday, April 20th at 7pm EST for "Human Rights
at Home and Abroad." During this presentation, our speakers will explore the
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03.26.15 - On Monday,
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heavy rain and thundershowers—with dangerous flash flooding predicted in the
string of border communities that stretch along the Rio Grande in the state's
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It was a busy night spent with food, drinks, and lots of furry friends!
The fundraising walk is a full-blown festival this year, with food trucks, live music and more. Bring your pooch and help support the KHS and its good work.
The Kentucky Humane Society made a Facebook post asking animal friendly businesses to welcome their foster ambassadors and animals, do you know any?
We resolve to make sure we support Louisville's no-kill shelter, and all the good they do for homeless cats and dogs.
Partner yoga -- with a four-legged partner -- equals Doga.
You're invited to walk with your four-legged friend at The 11th Annual Bark in the Park and Woof Walk on September 27 for a great cause.
Remembering the pets we've lost with others can help ease the grief. Saint Andrew's has organized a special candlelight vigil.
A little shopping, some photos and a nice long walk, among other activities, will get you involved with Louisville animal rescue efforts.
Adopt, don't shop! Parker has lots of energy and enthusiasm for life and is eager to join a loving family.
Dogs have a wonderful ability to love unconditionally and give second chances. Scout needs you to give her a chance at a happy life.
There isn't a whole lot better than helping an animal in need--and for only four dollars? What's not to love?
Hand-in-Paw Rescue would like you to meet Macey. You'll fall in love with this sweet 10-month-old Brindle Pit Bull pup. Adopt a rescue dog today!
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Catch up on all the Lions news from the past seven days with the Week in Review.
Cornerback Alex Carter is happy to be back on the field with his teammates, taking reps at both outside corner and in the slot.
After playing primarily in a backup role in Buffalo, defensive tackle Stefan Charles is hoping to be more of a difference-maker in Detroit.
Tim Twentyman and Mike O'Hara list their observations from open OTA practice.
WR TJ Jones speaks with the media after OTAs about learning from new guys and his role this season.
WR Marvin Jones talks to the media after OTAs about learning a new offense and what role he has to play.
WR Jay Lee speaks with the media after OTAs about making the move from college to the NFL.
CB Alex Carter talks to the media after OTAs about his return to the field.
Watch highlights from day three of 2016 Detroit Lions OTA practices.


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Jack of all trades master of none. Many projects and this fits almost all of them. Add the rotary tool options with 100% variable speed and even the smallest of projects can be...Read complete review
Jack of all trades master of none. Many projects and this fits almost all of them. Add the rotary tool options with 100% variable speed and even the smallest of projects can be worked. The flex shaft isn't super smooth and the twist or curve of it can affect RPM. I plan to oil it often to make it last. From polishing brass prepping it for solder on the heavy felt/wool left side or using the grinder on the right for bigger projects like sharpening a large machete it works great. I'm not sure it is OSHA recommended but it works as "laptop" polishing or sharpening station. You don't have to go nuts with the 10,000 rpm. In fact I don't think I ever have needed that much speed. That is the beauty of this item is that you can set a safe yet effective speed for your application. Don't expect a 20lb bench grinder. This unit is small enough to grab with one hand, put in a toolbox, and take with you to the job. It can be useful for almost any project. Perhaps it is the perfect match as a tool for all trades and specific to none.
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Bought this for the flex shaft, cos who's going to spend this much on a 3" bench grinder, seriously. After about 20 minutes using the flex shaft with some wire wheels...Read complete review
Bought this for the flex shaft, cos who's going to spend this much on a 3" bench grinder, seriously. After about 20 minutes using the flex shaft with some wire wheels one of the bearings slipped out and spun up to the wire brush. I thought maybe ill just push it back in and it will just be a quirk of a cursor tool. Well, it developed a pretty serious vibration. Hand went numb, bearing slipped out a few more times, grease all over. Painful story short, buy it for the grinder, not for the flex shaft. THROW THE FLEX SHAFT AWAY ! And it will be an excellent tool.
Reviewed by 73 customers
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Love this tool and It's in my Man-Cave
By Brian the lawnmower Man
from Fort Wayne, IN
About Me Casual Do-It-Yourselfer
Comments about Central-Machinery Bench Grinder with Flex Shaft:
This Tool is great on sharping Tools and then Buffing the Sharp Edge so there is no Nicks to have the Wife.And it's good for sharping the Grass Blades on a Mower.
Bottom Line Yes, I would recommend this to a friend
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Surprisingly good considering the price
By Picky
from Round Rock, TX
I just love this tiny grinder. The stone is on the soft side but that allows for very easy dressing. You can make it perfectly true in a matter of seconds. Once you get the stone straight, the tool becomes almost vibration free.The stone removes material at a decent pace, just do not apply too much force or you will stop the grinder due to its low power motor; that said, if you apply light pressure it works great. The best part is the stropping wheel. It is basically a dense scrub-pad wheel. I use without any honing compound and it leaves the cutting edges shinny and razor sharp in seconds. It is also very effective for polishing sharp edges and removing rust from small metal parts (or old tools). Again, the trick with this tool is "light pressure."The flex-cable is almost OK but it does work. I've had one for many years and the threaded plastic that holds the speed control in place broke. I tried to repair it but in the process I killed the variable speed control board. I immediately got another grinder. Cannot live without it.
Great little grinder/polisher
By The Flyer
from Arkansas
About Me Avid Do-It-Yourselfer
See all my reviews
I use it all the time, very smooth for small work.
exactly what i was looking for
By ike
from EL PASO, TX
hobby, lapidry, wood working, fits well in my shop
Great tool has a small problem
By carldirt
from Tucson, Az.
About Me Professional
This little bench grinder is a good tool to have for small jobs. There is only one problem with it that I have found and I have had four of them. The flexible shaft keeps breaking. This is the reason that I buy the warranty every time. Believe me it will break but, if you buy the warranty there are no questions asked and they will give you another one. That is why I rate it a five. At one point they came out with a different type of tip. It was better but, it also broke. It broke at the shaft wire. Too bad that this product isn't available any more.
Great tool
By WWJ
from Newark, DE
About Me Beginner
Just what I needed for sharpening carving tools. Excellent value with superb utility for a low power grinder.
Great for the price
By On the bench
from Columbia, SC
This is not a heavy duty grinder and not intended to be one. I have several old beat up chisels that were beyond honing by hand, but this little grinder got them into shape fast and I was able to hone them nice and sharp within minutes. Don't use the wheel for grinding wood and plastic unless you want to load it up and make it useless. For small grinding of steel it's perfect and having a variable speed is a real nice touch. It keeps from overheating tool steel. Just use light pressure and take your time. If you bare down you'll stall it so use this grinder for its intended purpose. I haven't used the flex shaft a whole lot, but what I did use it for it worked just fine with plenty of power and then some. By the way HF, I'm way past 13 years old. You don't need to ask anymore. )
Excellent even for professional knife making.
By KnifeMaker2000
from San Francisco CA
Got it for an excellent price with 20% off coupon and was able to fashion a flat stock of 1095 carbon steel into a knife. Although this does lack some power unless you plan to press against it really hard it will work just fine. This grinder is also quite small so is good for traveling. I have been making knives for decades and I was not put down by this.
Images shared by KnifeMaker2000
Sandwich there to show I didn't take from Google.
excellent value for the money
By none
from SEATTLE WA
good for very small jobs, I use mine to sharpen tungstens for my tig welder. The flex shaft has a million uses. Great price
love this thing
By Franny
from Mantua N.J
I used this to cleanup the small nuts and bolts, handles, etc. on my hot rod.it's nice and small for handling those things.worksout great for me.
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An effective internet advertising is the basis of successful sales!
Choosing one's advertising space, finding the keywords, writing competent ads &mdash this is far from everything needed for the advertisement to work. Any campaign can be made to work more effectively: spend less money but at the same time bring in more customers and deals.
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Nixon was speaking at Disney World when he famously declared, "I am not a crook."
Ecosystems and humans alike rely on vultures, and not only because otherwise we'd be knee-deep in carcasses.
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Erik Sass is covering the events of the war exactly 100 years after they happened. This is the 236th installment in the series.
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Make sure to pack lightly.
Blue is not one of those colors.
Give that old kitchen utensil something new to do.
The new law protects an employee's "right to disconnect."


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Key things you need to know aboutDr. Sami:
Dr. Sami's Experience
Research training, expertise and qualifications
Dr. Sami's Specialties
- Adult Medicine
- View all 2 Specialties and 1 board certification
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Patients' risk of dying during a hospital stay for heart bypass surgery could be 87.4% lower, on average, at a hospital rated 5 stars compared to a hospital rated 1 star for that procedure. Choosing the right hospital is critical to your health. View Slideshow
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If Angelina Jolie gets pregnant again, Jack Black says he is keeping his lips sealed. 0 1
Brad Pitt and Angelina Jolie's twins Vivienne Marcheline and Knox Leon made headlines yesterday when they graced the covers of People and Hello magazine. 0 1
You know who's celebrating his 7th birthday today? 0 1
Dustin Hoffman admits he didn't think Angelina Jolie would go far. 0 1
Angelina Jolie is leaving Cannes abuzz with talk of Oscar possibilities and her coming twins. 0 1
Last night Hollyscoop caught up with Jon Voight at the 'Forgetting Sarah Marshall' Los Angeles movie premiere where we talked to him about his estranged daughter Angelina Jolie and her pregnancy. 0 1
The Brangelina Bunch is going to have another heartbreaker on their hands. 0 1
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How do you think Angelina Jolie and Brad Pitt spent their Christmas day? 0 1
Lists! Lists! Lists! That's all we've been seeing for the past week and it's gonna continue till the end of the year. 0 1
Congratulations to Angelina Jolie for SAG nomination! 0 1


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Recovery of the virus from the cerebrospinal fluid of patients with encephalitis has rarely been reported. There are only 2 reports of this in the medical literature.1
During the epidemic of western equine encephalitis in Manitoba in July and August 1941, positive results were obtained with the spinal fluid from a 6 weeks old baby admitted to the hospital on August 19 with fever and convulsions which had become apparent the previous day. Lumbar puncture was done on admission. The fluid was slightly cloudy and contained 998 cells per cubic millimeter, 80 per cent of which were polymorphonuclears. There was a decided increase in globulin content. Organisms were not found on smear or culture.
On August 20, guinea pigs 1 and 2, each weighing approximately 300 Gm., were each injected intracerebrally with 0.2 cc. of spinal fluid from this patient. Guinea pig 2 remained well. On August 26 the
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text: tag:blogger.com,1999:blog-55182742016-05-04T17:28:32.734+01:00SchizopanicHi, I'm a person living in the North East of England who has schizophrenia. I have been in and out of hospital between 2001 and 2004. This blog will be notes about my experiences as a patient (aka client) both in hospital and in the community. I can be contacted via email to <b>email@example.com</b>. What is schizopanic? Its the panic that flashes through someone's eyes when you tell them you've got schizophrenia.Ianhttp://email@example.com:blogger.com,1999:blog-5518274.post-36222414774332719662016-05-04T17:28:00.001+01:002016-05-04T17:28:32.747+01:00An episodeSome time earlier this year, I started becoming unwell. In fact, I was paranoid about a certain thing so I hid the episode from people. Looking back it was probably a psychotic episode. After coming through the episode with no-one hurt I was ecstatic. Next time I might not be lucky.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-31916699154402175262015-07-30T18:31:00.000+01:002015-07-30T18:31:19.397+01:00Getting in touchI don't know how to edit the top of this blog. For the moment, if you need to contact me, don't e-mail firstname.lastname@example.com, please email email@example.com Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-28360550177777216862015-01-24T18:10:00.000+00:002015-01-24T18:11:06.776+00:00A bit more codeAnd here is the brains behind my stufftar backup (Bash) script... # perform_backup # $1 - stub of .tar.gz filename # $2 - name of log file e.g. "scripts/stufftarlog.txt" # $3 - directory to do the tarring in # $4 onwards - files/directories to put in .tar.gz file relative to $3 function perform_backup() { if [ $# -lt 4 ] then echo "Error perform_backup() insufficient no of parameters";Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-49612150983616700282014-11-12T19:19:00.001+00:002014-11-12T19:19:39.190+00:00A friend asked me today: what is your star sign? After a moment of thought, I replied: "a radio telescope".Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-37662391770218072102014-11-11T18:01:00.002+00:002014-11-11T18:01:28.240+00:00Done my first function in bash.Been doing a lot of Linux system's administration studies recently. Finished reading "Linux Pocket Guide (2e)" from cover to cover for the first time ever. Am returning to "Learning PHP, MySQL, JavaScript, CSS & HTML5". In the meantime, here is a function newly written for my stufftar backup shell script... function echo_and_log(){ if [ $STUFFTAR_VERBOSE -gt 0 ] then echo echo_and_log : Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-78091446637777409902014-08-03T17:49:00.001+01:002014-08-03T17:51:01.340+01:00Improved script file "synclamp"Initially synclamp (described elsewhere) tried to create its destination directory if it did not exist. I decided to check for its existence and exit synclamp with an error message. Here is the old code:- echo Ensuring destination directory $FILES_STICK exists mkdir -p $FILES_STICK Here is the updated code: # August 2014. If memory stick not found then exit with error message if [ ! -d $Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-27939556910390687912014-07-25T16:27:00.003+01:002014-07-25T16:27:36.364+01:00Done a little bit of (shell) programmingHere it is... #!/bin/bash# Script file to synchronise LAMP files. Ian Bruntlett July 2014FILES_LAMP=/var/www/htmlFILES_STICK=/media/$LOGNAME/DARWIN/lamp/htmlFILES_CP_OPTS="-irvua"echo Running $0ls -lh $0echo Ensuring destination directory $FILES_STICK existsmkdir -p $FILES_STICKecho Copy files from live LAMP directory to memory stickcp $FILES_CP_OPTS $FILES_LAMP/* --target-directory=$Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-44417665647846601072014-07-07T13:19:00.001+01:002014-07-07T13:25:18.027+01:00Business as usualHad a routine blood test today - just one bottle. Am trying to lose weight. I might not be eating properly because if I skip breakfast (porridge, skimmed milk and honey) I get dizzy spells. So instead of eating sandwich, salad and toast all the time, I'll also be eating other things - tinned food - that can go in the microwave.Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-89860945606530593292014-07-06T20:41:00.002+01:002014-07-06T20:41:48.227+01:00Operating SystemsAs most people know, Windows XP and Office 2003, both produced by Microsoft, both used by many people around the world, are no longer supported. This means bugs won't be fixed, support for new types of hardware won't be provided and security problems will go unaddressed. There are a number of options here. One is to buy a new/replacement PC with a new license of Microsoft Office. Another is to Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-71349442059279299162014-04-21T19:08:00.000+01:002014-04-21T19:08:11.879+01:00Paula's cat, Alice, had to be put down. Rest in peace. She is survived by Geraldine.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-27573429262919214442014-03-05T17:31:00.001+00:002014-03-05T17:31:18.704+00:00CookingFor the first time in over a decade I've cooked some stir-fry. It was lovely :)Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-44665412766860556292014-02-27T17:25:00.000+00:002014-02-27T17:25:31.110+00:00Linux VoiceA new Linux magazine has arrived - Linux Voice. Looks very interesting. They are going to re-license their content within 9 months of it being published. Very nice :)Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-20436608841671773262013-12-22T19:12:00.001+00:002013-12-22T19:12:56.200+00:00Been to a Christmas Carol service, thinking of you Dad.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-91759675333930073112013-11-23T14:58:00.000+00:002013-11-23T14:58:09.659+00:00Money saving tip - memory cards etcI was recently given some memory sticks by a friend (EH) for fixing her laptop (thankyou, EH). So I started looking on Amazon UK for dedicated USB memory stick pouches but all the suitable pouches were £16+. So I had a think. And I remembered I had some spare transparent pencil cases (which I previously used to hold unit cards when I was playing the Babylon 5 : A Call to Arms wargame). It turns Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-69060590666131056352013-11-18T14:05:00.003+00:002013-11-18T14:05:51.152+00:00To coin a phrase - abandonment anxiety...... is what people with mental health problems often have regarding their care in the community.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-20628792855091624042013-11-11T12:58:00.000+00:002013-11-11T12:58:09.369+00:00MiniaturesFor the first time in years I have started to paint miniatures for RPGs. This time it is the Judge Dredd figures by Mongoose Publishing.Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-29597172472354293202013-11-10T18:43:00.003+00:002013-11-10T18:43:40.449+00:00RelaxationHave taken this weekend off from doing C++ stuff. Yesterday was all 3 Jurassic Park films. Been listening to BBC Radio 1's Live Lounge 2013 today. Luxury :)Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-80030036449169051992013-10-24T19:05:00.001+01:002013-10-24T19:05:39.732+01:00When I was a teenage coder, for English Literature I was told to read the classics... so I spent 5 weeks worth of pocket money on "The C Programming Language" by K&R.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-552208507581779512013-10-24T16:39:00.001+01:002013-10-24T16:39:31.214+01:00Experience is a harsh mistressThis month's lesson is... Act in haste, repent at leisure.Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-86552094306860013582013-10-21T16:38:00.000+01:002013-10-21T16:38:46.050+01:00Reality Poisoning.Since I was a teenager. I suffered from Reality Poisoning which I escaped by playing Dungeons & Dragons (and, later on, Mongoose Traveller). I was having a Reality Poisoning spell over the weekend when I realised it was similar to what other people call Depression.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-51134228074588597482013-10-03T19:28:00.002+01:002013-10-03T19:28:54.452+01:00Neurocomic by Dr M. Farinella and Dr H. RosThis is a graphic novel about the mind and the brain. It's something that I've been studying on Wikipedia for some time. It's brief and easy to read. It may take concerted effort to remember the key parts - however, I think the effort involved is worth it.Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-21484811913502801952013-09-29T13:50:00.004+01:002013-09-29T13:50:56.628+01:00Cinema and Mental HealthI went to see Blue Jasmine recently. It was a good film with a real life kind of ending. Cate Blanchett was excellent as Jasmine. We get to see the side effects of a mental health problem but it's not mentioned in the film's dialogue - but Jasmine does take a lot of pills.Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-36186546848656080312013-09-21T16:56:00.000+01:002013-09-21T16:56:32.540+01:00 H1 { margin-bottom: 0.21cm; text-align: center; text-decoration: underline; }H1.western { font-family: "Tempus Sans ITC",sans-serif; font-size: 16pt; }H1.cjk { font-family: "WenQuanYi Micro Hei"; font-size: 16pt; }H1.ctl { font-family: "Lohit Hindi"; font-size: 16pt; }P { margin-bottom: 0.21cm; }P.western { font-family: "Tempus Sans ITC",sans-serif; }P.cjk { font-size: 10pt; } Ian Bruntletthttps://email@example.com:blogger.com,1999:blog-5518274.post-89470572097218345992013-09-04T18:57:00.001+01:002013-09-04T18:57:26.592+01:00 P { margin-bottom: 0.21cm; } LGBT friendly. P { margin-bottom: 0.21cm; } It seems that prejudice against the LGBT people is still all too common. From my own limited experience of hate crime – as a schizophrenic – I have decided to delare myself as LGBT friendly. Ian Bruntletthttps://firstname.lastname@example.com:blogger.com,1999:blog-5518274.post-1985122552450279762013-08-28T18:21:00.000+01:002013-08-28T18:21:26.147+01:00Been neglecting my C++ studies doing householder stuff and basic systems administration. Almost ran out of space on my main memory stick (16GB) so I ordered a 32GB stick from Amazon UK for just over £13. In the late 1980's, a Miracle Systems 40MB hard disc for the Sinclair QL costed £450. According to my calculations, my new memory stick was equivalent to just under 820 Miracle System's hard Ian Bruntletthttps://email@example.com


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He will look dashing in this boy's husky two-piece herringbone suit from Dockers. Classic tailored styling makes this boy's suit perfect for any important occasion. The subtle herringbone pattern, notched lapel and two-button front add a polished look. Fully-lined pleated pants, belt loops and trouser pockets complete this tailored ensemble.
- Husky sizes available
- Set: Jacket and pants
- Jacket: Notched collar, single welt chest pocket,two front faux flap pockets, interior single welt pocket
- Pants: Hook and zip close, pleated, front trouser pockets;two rear button pockets
- Jacket and pants: 100% polyester
- Care: Dry clean only
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Officials: Walk-ins are breaking law
BARRE State officials say they disagree with a Vermont State Police station commander over whether a stranger walking into someones house commits a crime.
State police Lt. Paul White said Wednesday for a Times Argus article that an incident Dec. 1 in East Montpelier, in which a man walked into a home without knocking, was not criminal. He said the state police would have to show that the man intended to steal from the home for it to be a crime.
However, Washington County States Attorney Tom Kelly said Thursday that if he were presented with that situation, he would prosecute for unlawful trespass.
According to state statute, a person cannot enter a dwelling house, whether or not a person is actually present, knowing that he or she is not licensed or privileged to do so.
That kind of unlawful trespass is a felony with a maximum sentence of three years in prison.
Montpelier Rep. Warren Kitzmiller, a Democrat, said he had been contacted by constituents Thursday morning concerned about the article. He said one constituent asked whether people had to put No trespassing signs around their property to keep people out.
Kitzmiller said he contacted some members of legislative committees handling criminal law and they agreed that such conduct would be unlawful trespass.
White could not immediately be reached for comment Thursday.MORE IN This Just InWESTMINSTER Vermont State Police say a passenger has died in an off-road vehicle crash in... Full StoryPOMFRET More than 1,000 trees and shrubs have been planted along three rivers in New Hampshire... Full StoryWATERBURY Vermont State Police are investigating a weekend burglary at the Snowfire Auto... Full Story
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Freedom Of Speech? Not Important To 40% Of This Group
At this point, climate change won't bring about the demise of our civilization, but Millennials and their feelings might. The majority of the M Generation bases everything on the emotions of the moment, not facts. But you already know this because you've observed what is happening at Mizzou, Amherst, and other institutions of "higher learning" across the nation. College kids, who stomp their feet at | Read More »


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(WJLA) - A Prince George's County Police officer is seriously injured after a minivan crashed into him during a traffic stop in Forestville this morning. Two other officers barely escaped injury, but then turned around to help lift a vehicle off their injured colleague.
The injured officer has been identified as 26-year-old Bashua Olaseha. Police say he remains in serious condition at Prince George's Hospital Center after he was trapped under a minivan for several minutes before he was finally freed.
Hundreds of officers later came out to show their support for one of their own.
"We want to thank the community for all their thoughts and prayers," said Chief Mark Magaw with PGPD.
Police say the driver seen being loaded into an ambulance was behind the wheel of this minivan when he plowed into three patrol cars parked on the shoulder of the road. Two officers managed to jump out of the way, while the third dove into a ditch - where the minivan landed on top of him.
"The ground was wetyou can see the indentation of his body, the ground gave enough to where there wasn't a critical accident or fatal accident," explained Chief Magaw. He adds that the woman who was initially pulled over near Pennsylvania Avenue and Walters Lane even jumped out to try to help.
"It's been a harrowing morning for us, but this officer is going to survive this incident," he said.
The Police Chief and the President of the Fraternal Order of Police both say they've had a tremendous amount of support from the community and from people all across the country. It's an issue that hits close to the heart for many at the police department, since two officers have died in the line of duty in the last four years.
"This is a very sensitive issue for us, and by grace of God we didn't have to repeat that today," said Chief Magaw.
It is still unclear exactly why the driver veered off the road, but police say charges have not been filed at this point while they continue their investigation. Police say Olaseha is an Iraqi war veteran who has been with the department for about a year-and-a-half.


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Muskego police are looking for a suspect in an attempted strong-arm robbery in the parking lot of Sauced Restaurant, W16355 Woods Road, that happened at about 6:45 p.m. Saturday.
A woman reported to police that a man knocked her down and attempted to steal her vehicle. The suspect could not find her vehicle keys in her purse and ran off. She described him as about 5 feet 10 inches tall, weighing 160 pounds and wearing a black hooded sweatshirt and blue jeans.
Officers searched the area using the Waukesha County canine unit, but the suspect was not located.
Anyone with information is asked to call police at (262) 679-4130.
More from News and Features
- Energy savings almost pay for new gym floor at Muskego High School (1)
- Parkland Mall redevelopment ready to go ahead after getting sixth vote (1)
- Muskego Plan Commission recommends controversial Parkland apartments
- Former West Bend administrator waives right to hearing in Muskego case
- Former Green Bay Packer LeRoy Butler to be part of Muskego Jammin' on Janesville
- Former Packer LeRoy Butler to be part of Muskego Jammin' on Janesville
- Muskego Plan Commission to hold special meeting on Parkland Mall plan
- Video: Summer fun in suburban Milwaukee
- Muskego aldermen declare positions on controversial Parkland Mall plan (3)
- Muskego Police Blotter: May 19, 2016


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The 1940 Clark County Courthouse has retained its brass-trimmed entry doors and fixtures, but they've long since lost their luster.
A $33,000 grant from the state Department of Archaeology and Historic Preservation will pay for a professional restoration of the brass-trimmed doors, brass elevator doors and brass railings, lights and mullions in the large window above the front entrance.
The grant requires the county to provide matching funds, so commissioners are expected to vote this month whether to accept the grant, said Mark McCauley, the county director of general services.
McCauley applied for the grant knowing he has the $33,000 matching dollars in his facilities budget.
"The appearance of all that brass has really gone south over the years," McCauley said. "We are trying to return it to its former glory."
Work could include tearing up the carpet in the hallway on the south side of the first floor — where the jury assembly room, snack bar and law library are located — and restoring the original terrazzo floors to match the central lobby, McCauley said.
The courthouse, which has five floors and a basement, was designed by architect Day W. Hilborn (1897-1971), whose work includes Kiggins Bowl (described by the Department of Archeology & Historic Preservation as "an engineering masterpiece at the time"), Kiggins Theater and projects not named for the late Vancouver Mayor John P. Kiggins, such as smaller theaters in Oregon and the Klickitat County Courthouse.
When the courthouse opened at 1200 Franklin Street, there was one courtroom, and the top floor
housed the jail. The Clark County Prosecutor's Office was once in the courthouse, as were non-court-related county offices such as the auditor, treasurer and the assessor.
The courthouse's major remodels include a $8 million remodel in 1987, which doubled the number of Superior Court courtrooms from three to six, and a $5.4 million remodel in 2003 that added two courtrooms on the third floor, as well as two ground-floor courtrooms and a jury assembly room.
Through all of the renovations, the courthouse has retained the brass work.
"We don't have a lot of historic buildings around here, so maintaining what we have is always nice," McCauley said. "We're looking forward to getting it done."
If commissioners approve the grant, the work would be put out for bid. Some of the work is particularly time-consuming, such as the ridged doors on one of the elevators, McCauley said. The pieces have to be stripped, shined and covered with a sealant to prevent the brass from oxidizing and darkening.
The state money would come out of the Historic County Courthouse Rehabilitation Grant program, established in 2005 after a study concluded that 32 of the state's 39 counties have courthouses with "historic and architectural merit," according to the Department of Archaeology and Historic Preservation. The Legislature allocated $5 million in both the 2005-07 and 2007-09 state capital budget, along with $2 million in 2009-11 for courthouse rehabilitation projects.
For 2011-13 budget, $750,000 has been earmarked for rehabilitation projects such as Clark County's.
Stephanie Rice: http://www.facebook.com/reporterrice; http://twitter.com/col_clarkgov; email@example.com.


text: Hey I have Netgear DGN3500 wireless router which I am buying from one of hardware shop. I am trying to connect it to my computer but while connecting I am facing some connection problem. I have done this several time but still I am facing the same problem. I think I am doing something wrong with my Netgear DGN3500 connection sp please give me your opinion so that I can get out of this problem.


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Custom luggage tags with a logo on one side and ID pocket on the other (holds the size of a standard business card).
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This flexible custom book light clips onto books to make reading in airplanes or at night easy.
Whether you love hitting the gym or a frequent flyer or both this promotional duffle bag.
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Made with a naturally soft litchi fabric this Lamis promotional laptop shoulder bag has the high end look and feel your clients will appreciate.
Reduced price promotional products on sale at ePromos. Save money on your next marketing campaign or event with these cheap promotional items.


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Below is a list of the most popular customer scuba gear reviews for Communication, Underwater Communication Accessories. Click the product name to view more reviews and details about that product. For longer reviews, click the View Full Review link next to a review to read the whole review.
You can see the most helpful scuba gear reviews for communication below. Scuba.com offers gear reviews from the following manufacturers: Ocean Reef, Ocean Technology, Trident and more...
Reviewer: Aodhan O.Love it! - I wasnt sure the price was going to be worth it, but it is! I love my Ocean Reef full face mask and the only problem was coming out of the water and having it hang by my side. Then trying to rinse it. I purchased the quick disconnect hose and it gives me two important features. One I just feel comfortable having the additional length of the hose. Second the quick connect allows me to assemble just when I am ready to don the mask. Also after a dive I remove without fear of it being bashed around. I can rinse it quickly, let it dry and place it safely away. No more staying attached to my second stage.
Reviewer: Edward S.BEST UNDER WATER SIGNAL DEVICE I HAVE TRIED!!! - WE HAVE TRIED EVERY UNDERWATER SIGNAL DEVICE THAT COMES OUT! I CAN NOT HEAR ANY OF THEM. THIS IS THE FIRST DEVICE I COULD ACTUALLY HEAR!!!! FANTASTIC.
Reviewer: diana j.Ocean Reef SAV - this is a must have for the ocean reef mastconserves precious tank contents while on the surface without having to remove your ffm.
Reviewer: Pim De Rhoodescommunication - Very nice professional service for a great product.
View all Scuba Gear Reviews View all Communication - Underwater Communication Accessories


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Mandolin by kpmycoskieWatch
©2004-2016 kpmycoskie
I see you in my music.
rad man!
Great concept, and great work. Its simply beautiful.
The caption really epitomizes the meaning of the photo for me.
This is a captivating work of art.
This is a captivating work of art.
What I like about this picture is that the image of the human figure is inverted, exactly the way it would be if I were looking into a spoon.
It makes it look as though the mandolin had a concave, reflective face, like the spoon. Good work.
It makes it look as though the mandolin had a concave, reflective face, like the spoon. Good work.
That's beautiful!
Hey! In the comment above you mentioned having somethinglike a series of shots with this idea...I was just wondering if you were going to release any more because it's an absolutely beautiful shot and amazing idea!
beautiful work here.. i love the fact that she's upside-down..
Thanks, I appreciate it. It was actually a part of a series I did with silouettes in instruments...maybe Ill post more later. Thanks.
nice ideaaaaaaaaaaaaa yeah great job!


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PSO : Analysis & Opinions
10 Stocks to Watch Due to a Weaker Euro (JAZZ, FLTX)March 9, 2016Learn about factors that impact the performance of the euro in 2016 and the top 10 European stocks that will see the greatest ...
Top 4 Stocks Listed on the London Stock Exchange for 2016 (PSO)February 16, 2016Discover why the London Stock Exchange provides many good investment opportunities in 2016, and learn about the top British ...
Pearson Sells Out of Its Stake in The Economist (PSO)August 14, 2015The ownership structure of the business and current affairs magazine The Economist has changed drastically. On Thursday, ...
Pearson in Talks to Sell 50% of The Economist (PSO)July 30, 2015Pearson (NYSE: PSO) has disclosed that it is in talks to sell its 50% stake in the current affairs and business weekly magazine ...
Financial Times Sold to Japanese Media Group (PSO)July 24, 2015Capping months, if not years, of speculation about its fate, the Financial Times has been sold to a new owner. The newspaper's ...
How Obama Gave 2 Stocks A Huge Potential CatalystJanuary 26, 2015Despite strong resistance from the Republican party, President Obama has been surprisingly adroit in moving his agenda through ...
Archipelago Learning In Detention, But Still On Course To GraduateFebruary 29, 2012Archipelago has seen growth pause, but the long-term picture is appealing.
McGraw-Hill Plans To SplitSeptember 16, 2011McGraw-Hill will split into two public companies after pressure from shareholders.
The Glass Is Half-Full At Thomson ReutersJune 10, 2011There are many Thomson Reuters detractors in the investor relations industry, but you could say the glass is half-full for ...
Greenblatt's Little Book Loves McGraw-HillApril 1, 2011In Gotham Asset Management's latest 13F, McGraw-Hill is its third-largest holding. We'll look at why.
Scholastic Embraces Digital EducationMarch 30, 2011Scholastic had a rougher than usual third quarter, due in part to uncertainty in school funding by states.
Archipelago Learning - Not All 'For Profit' Education Is The ...November 15, 2010Archipelago may be involved in education and profits, but it is a totally different type of company.
Scholastic Goes Back To SchoolSeptember 29, 2010The children's educational publisher posted larger than usual losses for its traditionally slow summer quarter.
Slowing U.K. Growth Could Hit ADRsAugust 7, 2008Learn which ADRs could be hurt by the IMF's gloomy GDP forecast for the United Kingdom.
Trading Center


text:
Wilsonville's Latest News
Ask a cop
Eagle Scout wins national award
Clackamas County set to consider budget
Wilsonville police log
Armed robbery reported at French Prairie Rest Area
News in Brief
State business tax plan would raise billions, but could 'dampen' employment, growth
Charbonneau Clubhouse packed for fashion show
New Columbia Gorge Express bus service launches May 27
Wilsonville police log
A world of art at the Wilsonville Public Library
WL-WV announces superintendent finalist
Another successful W.E.R.K. Day for City
Smith, Humberston appear headed for runoff in Clackamas County
Schrader wins race for Position 3 on Clackamas County commission
Infrastructure looms large in City budget
Oregon schools lack enough nurses for student population, needs
Climbing the ladder
Congressional bill would benefit Wilsonville business
Details are set for road design at Wilsonvile Road terminus
Position 4: A matter of both style and substance
Technology, nature intersect at Graham Oaks
Local news in brief
Missing Beaverton girl found in Wilsonville
Candidates, parties shake off 'bland' politics to attract young voters
Clackamas Community College bares its 'Art & Soul'
Future park gets amphitheater
Wilsonville police log
Race for position No. 3 heating up
Thinking about naming your new daughter Emma? Think again
Schrader talks compromise at Rotary meeting
Cemetery season in Wilsonville
County commission chair contest echoes four-way race of 2012
Schrader predicted to keep 5th district seat
Terry Porter delivers inspiration to Portland area's 'Amazing Kids'
A pragmatic approach to politics
Firefighters 'Fill the Boot' for Muscular Dystrophy Association
Fall runoff likely for county commission chair spot


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... testing by GDH-PQQ testing methods. Is the dose of WinRho given during pregnancy or postpartum high enough to cause an error in blood glucose testing using GDH-PQQ method? Or is a higher dose (like that given for ITP) required?
Rh-Isoimmunization - WinRho is one of the medications listed as interfering with blood glucose?
- Posted:
- 8 Sep 2009 by vogel
- Topics:
- winrho sdf, rh-isoimmunization
Responses (1)
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Which One Do You Like? Macro Bee 1, 2, or #
Started May 30, 2012 | Discussions thread
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bittybong • New Member • Posts: 5
Re: Which One Do You Like? Macro Bee 1, 2, or #
Hi, I think number one, as the bee is more obviously a bee with the legs showing hanging on. Nice!
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Liverpool captain Steven Gerrard is in line to return for tomorrow's clash with Hull City at Anfield.
Gerrard has been sidelined with a hamstring injury picked up in the 4-1 victory over West Ham on December 7 and was expected to be out for six weeks.
However when asked if Gerrard might be fit enough to face the Tigers on Wednesday, Liverpool manager Brendan Rodgers said: "We will assess that over the next 24 hours.
"Steven has rejoined training so we'll see how he is for Hull."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball


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- BoliviaServicesFunding via CIDRE
Alejandra D...BoliviaTransportationFunding via CIDRE
Erika JennyBoliviaServicesFunding via Emprender
9 De Noviembre Group
This loan will benefit small micro-entrepreneurs, such as Sra. Carmen who is one of the members. She says that she joined Pro Mujer eight years ago after receiving an invitation from an aunt who also participates in a Communal Bank. At the moment, Carmen operates a metal shop. She learned this trade years ago from one of her relatives.
The loan she is receiving now will increase her capital for purchasing iron. She acquires her supplies from hardware shops and then makes the products that she sells from her retail space. Working in this manner enables her to generate the income she needs to support her family financially. Carmen is married and has two children.
When asked what she likes about Pro Mujer, Carmen said that she enjoys the seminars given by the consultants and the health classes.
El crédito que sacaran beneficiara a pequeñas microempresarias donde la señora Carmen es integrante, ella indica que hace ocho años que integra Pro Mujer, ingresando por ingresando por invitación de una tía que participa en una banca comunal. En la actualidad ella tiene un negocio de cerrajería (soldado de metal); cuenta que este negocio lo emprendió desde hace años atrás aprendiendo este oficio de uno de sus familiares.
El crédito que ahora sacará es para el aumento de capital (compra de compra de fierro) que adquirirá de las ferreterías posteriormente a la elaboración lo comercializa en su espacio de venta. Esta forma de trabajo le permite generar recursos para apoyarse económicamente a su familia pues ella es casada y tiene dos hijos.
Cuando se le consulta qué le gusta de Pro Mujer, ella responde que le gusta las capacitaciones de las asesoras y del área de salud.
Additional Information
This is a Group Loan
In a group loan, each member of the group receives an individual loan but is part of a larger group of individuals. The group is there to provide support to the members and to provide a system of peer pressure, but groups may or may not be formally bound by a group guarantee. In cases where there is a group guarantee, members of the group are responsible for paying back the loans of their fellow group members in the case of delinquency or default.
Kiva's Field Partners typically feature one borrower from a group. The loan description, sector, and other attributes for a group loan profile are determined by the featured borrower's loan. The other members of the group are not required to use their loans for the same purpose.
About Bolivia
123View loans »
Success!! The loan was 100% repaid
- Repayment Term
- 8 months (Additional Information)
- Repayment Schedule
- Monthly
- Pre-Disbursed:
- Oct 31, 2012
- Listed
- Nov 10, 2012
- Currency Exchange Loss:
- Covered
- Ended:
- May 17, 2013


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Zip into head-turning style with this alluring knee-length bandage skirt. Pair it with a lightweight sleeveless blouse and patent pumps for effortless elegance.
• High-waisted bandage skirt. Hits below the knee.
• Full-length two-way zipper closure at center back
• Measures approximately 26" from waist to hem
• 85% Rayon, 14% Nylon, 1% Spandex
• Hand wash
Measurement taken from a size small
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With the Russian presidential election coming up next Sunday, I have been paying more than usual attention to Johnson's Russia List (JRL), which arrives nearly every morning at my desk via email, with the complete texts of yet another thirty or forty news stories about what is happening in Russia, mostly from the English- and Russian-language press, but with plenty of European and Israeli dispatches thrown in. I groan a little each time I call up a new packet.
JRL is the one-stop kiosk for anyone interested in what is happening in
David Johnson, sixty-ish, workaholic, resumes the work of the previous evening each morning when his teacher wife leaves for school. A similar service, in a somewhat more edited format, for people interested in the
I skim down Johnson's story list, pick out the two or three articles that attract me, and read them. He has access to various sources that translate Russian and other foreign-language media, several
A birthright Quaker (his father was for many years an official of the American Friends Service Committee in
Western economists, you'll remember, split broadly into two camps in the 1980s, gradualists and those who counseled one form or another of "shock therapy." The latter, "market Bolsheviks," in Peter Reddaway's description, quickly gained the upper hand in the feverish atmosphere of the 1990s, as Boris Yeltsin, following a centuries-old pattern of government-led development (Ivan the Terrible, Peter the Great, Nikolai Lenin, Josef Stalin), sought to create a new privileged class of committed supporters – in this case, a relative handful of vastly wealthy robber-barons. Books like The Oligarchs: Wealth and Power in the New Russia, by David Hoffman, of the Washington Post, and Sale of the Century: Russia's Wild Ride from Communism to Capitalism, by Chrystia Freeland, of the Financial Times, chronicled the market reformers' stories, but have otherwise failed to keep up with the times.
The original parties to the controversy today are somewhat fatigued, their accounts of their battles inevitably tinged by self-pleading. (An exception is the indefatigable Marshall Goldman, of Wellesley College and Harvard University's Davis Center for Russian Studies, about to publish his sixth book of narrative since 1983, Petrostate: Putin, Power, and the New Russia.) We must wait for a new generation of scholars to come of age, steeped in archival sources on all sides, Bush and Clinton, Gorbachev and Yeltsin, in order to form firmer opinions.
Meanwhile, we will make do with what we've had all along: a carefully-chosen and well-seasoned press corps, whose veterans advance regularly into the senior editorial ranks of The New York Times, The Washington Post, The Wall Street Journal, the Financial Times, The Economist and The New Yorker, where they continue to refine their opinions of what is happening in
Indeed, the expected outcome of the Russian election is useful not just in terms of thinking about
Here's how The Economist framed the issue:
Look a bit further ahead, and two broad scenarios seem possible in
. The first is one in which the Communist Party oversees the introduction of capitalism while retaining political control—in the mould of China, Vietnam or, closer to home, Mexico in the heyday of the Institutional Revolutionary Party. That seems to be the route favored by senior figures in the regime, few of whom show any signs of being closet democrats. The other scenario is the one long dreamed of in Cuba Miamiand in , of the regime's sudden collapse and, it is assumed with a confidence many Iraqis may find worryingly familiar, a swift move to liberal democracy. Washington
Note, however, that in all likelihood, that "dream in Washington" is about to change, decisively (and the dream in Miami is no longer what it was even a decade ago, when Cuban expatriates formed a single intense generational bloc).
Here's how
I do think it is important, precisely because the Bush administration has done so much damage to American foreign relations, that the president take a more active role in diplomacy than might have been true 20 or 30 years ago. Because the problem… is if we think that meeting with the president is a privilege that has to be earned, I think that reinforces the sense that we stand above the rest of the world at this point in time, and I think that it's important for us, in undoing the damage that has been done over the last seven years, for the president to be willing to take that extra step. That's the kind of step that I would like to take as president of the
. United States
So many things change when the political rudder is thrown over, as seems likely soon to be the case. Then the van of history itself comes about, and sails off on a different tack. I'll admit to being nervous about Obama. But let's see what he can achieve.
Throw the tiller over! Come about!
As expected, James Poterba, of the Massachusetts Institute of Technology, last week was named president and chief operating officer of the National Bureau of Economic Research. EP already has said much of what there is to say. But the general excellence of the choice cannot be affirmed too frequently.
Poterba's own research over the years in public economics has been interesting enough. His editorship of the Journal of Public Economics was exemplary. But he also has been a superlative teacher. Among the better-known economists he advised as graduate students are Jeffrey Brown, of the University of Illinois (nominated to be a public trustee of Social Security & Medicare); David Cutler, of Harvard University (health care outcomes research); Amy Finkelstein, of MIT (health care demand and social insurance); Austan Goolsbee, of the Graduate School of Business of the University of Chicago (chief economic adviser to Obama); Steven Levitt, of the University of Chicago (Freakonomics); Brigitte Madrian, of Harvard University's Kennedy School of Government (author of a seminal paper in behavioral economics, "The Power of Suggestion," about opt-in vs. opt-out); Mark McClellan, of the Brookings Institution (former commissioner of the Food and Drug Administration); Emmanuel Saez, of the University of California at Berkeley (expert on evolving US income distribution); and Luigi Zingales, of the GSB of the University of Chicago (Saving Capitalism from the Capitalists).
One of the things that made Martin Feldstein so successful during his thirty years as NBER president is that, with his economist wife, Kathleen, he lived, breathed and served economics at the dinner-table. So, too, do Poterba and his economist wife, Nancy Rose, also of MIT. Like the Feldsteins, they are a familiar presence in suburban
Peter S. Albin, a deep thinker and a lively man, died last week after a long, gallant struggle with an injury to his brain. He was professor emeritus at the City University of New York; had been a visiting scholar at Cambridge University, the University of California at Berkley, the University of Paris and Oxford University; and was on the verge of accepting a distinguished professorship at Bard College and its Levy Institute when, in 1991, a stroke robbed him of his strength.
Albin was the author of three books — The Analysis of Complex Socioeconomic Systems (1975); Progress without Poverty: Socially Responsible Economic Growth (1978); and Barriers and Bounds to Rationality: Essays on Economic Complexity and Dynamics in Interactive Systems (1998). He was the central figure in my own The Idea of Economic Complexity (1984). He was a shrewd proponent of indicative planning, but even then, I didn't find it easy to explain what I thought he did. I came to think of him as the Jane Jacobs of mathematical sociology.
He had a loving family and many friends, among them Hyman Minsky, Janos Kornai and Eileen Applebaum. No colleague served him better, though, than Duncan K. Foley, of the


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