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IFI Members in the News
March 22, 2016
A study led by Montserrat Anguera of Vet has uncovered the first mechanistic evidence for why females are more susceptible than males to certain autoimmune conditions.
Two Studies Strengthen Links Between the Zika Virus and Serious Birth Defects
March 7, 2016
Sara Cherry, PhD, an associate professor of Microbiology, commented in the New York Times about two Zika virus studies on the link between the virus and microcephaly. She noted that noted that cells used in the highlighted preclinical study were infected with a Zika strain "quite distinct" from the one now infecting people in Latin America.
Critical Details
March 7, 2016
Medicine's Gregory Beatty, Kristen Long and Whitney Gladney showed how specific immune cells can be "re-educated" to make pancreatic cancer vulnerable to chemotherapy.
Saving Theresa: The Race to Stop an Elusive Killer
February 29, 2016
Degos, a condition that afflicts perhaps a dozen or so people in the United States each year, causes brittle spots of dead tissue that can perforate at any time, spreading bacteria and infection throughout the body. The Philadelphia Inquirer interviews Peter A. Merkel, MD, MPH, chief of the division of Rheumatology, and an expert on rare diseases, about coordinating a patient's Degos treatment.
Congratulations David Roth!
February 26, 2016
It is with great pleasure to announce the appointment of David B. Roth, MD, PhD, as Director of the new Penn Center for Precision Medicine (PCPM), a greatly expanded effort in this burgeoning field. In his new role, Dr. Roth will work with the many stakeholders invested in this field to accelerate the implementation of precision medicine into clinical care.
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Penn Medicine, Novartis Open Center for Advanced Cellular Therapeutics
February 26, 2016
On Tuesday night, physicians, scientists and leaders from the Perelman School of Medicine and Novartis unveiled the Center for Advanced Cellular Therapeutics (CACT), reports 6ABC and WHYY. The CACT, made up of nearly 24,000 square feet of lab and cell therapy manufacturing space, will serve as an epicenter for research and early development of personalized T cell therapies.
Living a Full Life
February 23, 2016
A piece in the Princeton Packet featured a Penn patient and former mayor of the town, Phyllis Marchand, and her involvement with the Perelman School of Medicine's Longitudinal Experience to Appreciate Patient Perspectives, or LEAPP, program. Marchand's clinician, Alain Rook, MD, a professor of Dermatology, is also mentioned in the story.
A Way In
February 16, 2016
Using powerful microscopy, Vet prof Christopher Hunter and postdoc Christoph Konradt showed how the Toxoplasma parasite breaches the blood-brain barrier.
Advances in Personalized Medicine Must be Balanced with 'Clinical Reality'
February 9, 2016
HemOncToday quoted David Roth, MD, PhD, chair of Pathology and Laboratory Medicine and director of Precision Medicine, in its coverage of a Cancer Action Network-hosted round table on the practicalities and availability of personalized medicine.
Changing Diapers
February 4, 2016
Baby poop may be an important data source to learn how the risk of obesity develops in early life, according to a study by Babette Zemel and Gary Wu of Medicine and CHOP.
Vice President Biden Kicks off "Moonshot" Effort at Abramson Cancer Center (Photos)
January 22, 2016
Days after President Obama announced the "moonshot" to find a cancer cure during his State of the Union, Vice President Biden visited Penn's Abramson Cancer Center to kick off the national effort he said aims to "accelerate the progress already underway" – much of which is happening right here.
Vice President Biden's "Moonshot" Push to Find a Cure for Cancer
January 21, 2016
Carl June, MD, director of Translational Research at the Abramson Cancer Center, was a guest on NPR's "On Point" to discuss the "moonshot" effort put forth by Vice President Biden, who toured and met with researchers at the ACC last Friday. "[The vice president] is looking for how can we take the tool box that we have, which has never been so full….and accelerate the cure of cancer," June said.
(Starts at 30:34)
Vice President Biden Launches "Moonshot" Effort at Penn's Abramson Cancer Center
January 18, 2016
On Friday, Vice President Joseph Biden visited Penn's Abramson Cancer Center to kick off his national "moonshot" effort to find a cancer cure, reports CBS News, the Associated Press, CNN, and many other national and international outlets. Biden toured a first-of-its-kind research hub at Penn that will serve as the epicenter of its personalized T cell therapy program and met with top experts in immunotherapy, cancer prevention, surgery, genomics, and more at the ACC and Perelman School of Medicine.
Too Cautious About Food? That's Dangerous
January 18, 2016
Bloomberg View weighed in on the recent changes in dietary recommendations, highlighting consumption in moderation versus eliminating certain foods entirely, and cautioning that when people are told to avoid one thing they often consumer too much of another. Comments from Daniel J. Rader, MD, chief of the Division of Translational Medicine and Human Genetics, are referenced.
How a Penn Cancer Research Center Caught Joe Biden's Attention
January 15, 2016
Previewing Vice President Biden's visit to Penn's Abramson Cancer Center (ACC), STAT highlighted some of the groundbreaking immunotherapy work to come out of the ACC, described by the VP's office as "cutting edge." The article also featured Chi Van Dang, MD, PhD, director of the ACC, Robert Vonderheide, MD, DPhil, associate director of translational research at the ACC, and Carl June, MD, director of translational research at the ACC.
Vice President Biden to Visit Abramson Cancer Center
January 15, 2016
As part of his national "moonshot" effort on cancer, Vice President Joe Biden will visit Penn's Abramson Cancer Center Friday to speak with physicians and scientists leading the charge in the fight against the disease, reports NBC Nightly News, The New York Times, and other outlets. Robert Vonderheide, MD, DPhil, associate director of translational research at the ACC, was also featured on NBC10.
Two Accolades
January 14, 2016
The Crohn's & Colitis Foundation of America has recognized Med's Gary Lichtenstein and Gary Wu with 2015 Inflammatory Bowel Disease Scientific Achievement Awards.
Camel Vaccine Offers Hope to Stop MERS
January 11, 2016
David Weiner, PhD, a professor of Pathology and Laboratory Medicine, comments in Science about the development of a MERS vaccine to suppress circulation of the virus in camels.
Kudos, Criticisim for New Dietary Guidelines
January 8, 2016
Daniel J. Rader, MD, director of the Preventive Cardiovascular Program, was quoted in a 6ABC story of the newly released USDA dietary recommendations, supporting the call for consumption in moderation.
Diet, Exercise Ease One Aspect of Heart Failure but not All
January 5, 2016
MedPage Today featured the results of a new study which found that lifestyle modifications may improve exercise capacity for obese older patients, but may not improve their quality of life. Mariell Jessup, MD, a professor of Cardiovascular Medicine, is quoted.
HBO Vice Special Report on HIV: Countdown to Zero
December 2, 2015
On World AIDS Day, Pathology and Laboratory Medicine professors Carl June, MD, and Bruce Levine, PhD, were featured in a special HIV report from HBO's Vice. June sat down with host Shane Smith to describe how his team successfully used a zinc finger technology to induce the CCR5 mutation — the same one found in Timothy Brown, the "Berlin patient" — in patients' T cells to lock out the virus. The show also features a tour of Penn's Cell and Vaccine Production Facility, showcasing how the gene editing process works.
Immunotherapies Changing Outlook for Cancer Patients
November 24, 2015
Abramson Cancer Center physicians Lynn Schuchter, MD, chief of Hematology/Oncology and David Porter, MD, a professor of Hematology/Oncology, were guests on WHYY's Radio Times, discussing advances in cancer immunotherapies.
U.S. Heart Groups to Weigh New Data for Hypertension Treatment Guidelines
November 16, 2015
Mariell L. Jessup, MD, a professor of Medicine and the directory of Penn's Heart and Vascular center, provided comment to Reuters on the guideline implications following the announcement of the SPRINT study results, which found that more aggressively lowering blood pressure in high-risk older patients can reduce cardiovascular and mortality risk.
Baby's Leukemia Recedes After Novel Gene Therapy
November 13, 2015
Bruce Levine, PhD, and Carl June, MD, both professors of Pathology and Laboratory Medicine, are quoted in articles detailing the recently announced case of a British baby whose blood cancer was treated with "off the shelf" genetically modified T cells from an unrelated donor.
No Scar
November 13, 2015
A study revealed how mouse ears regenerate without the tissue scarring, which may have implications for human wound healing, according to Thomas Leung of Medicine.
Vericiguat Misses Primary End Point of Lower NT-proBNP in Chronic Heart-Failure Patients
November 10, 2015
Mariell L. Jessup, MD, a professor of Medicine and medical director of Penn's Heart and Vascular Center, commented on the trial results of the heart failure drug vericiguat for the improvement of worsening chronic heart failure, in a Medscape article. Results were presented at the American Heart Association Scientific Sessions 2015.
November 10, 2015
A survey of the skin's viruses has found that 90 percent are viral "dark matter" that have never been described before, according to Elizabeth Grice of Medicine.
Nitrates No Help in Heart Failure
November 9, 2015
In a video interview with MedPage Today, Mariell L. Jessup, MD, a professor of Medicine, medical director of Penn's Heart and Vascular Center and moderator of the first AHA late-breaking clinical trial panel, commented on the results of the Nitrate's Effect on Activity Tolerance in Heart Failure (NEAT-HFpEF) trial and what physicians can learn from the data.
Medical Trials Underway Harnessing Modified HIV Virus for Cancer Treatment
November 5, 2015
PIX11, the CW affiliate in New York City, chronicled progress in the Abramson Cancer Center's trials using genetically modified versions of patients' own T cells to combat leukemia and other blood cancers. Alison Loren, MD, an associate professor of Hematology/Oncology in the Abramson Cancer Center, and Carl June, MD, a professor of Pathology and Laboratory Medicine and director of Translational Research in the Abramson Cancer Center, were featured in the story along with the first patient to participate in this clinical trial, who remains in remission more than five years after receiving the investigational therapy.
Penn Scientist Reveal 90 Percent of Skin-Based Viruses Represent Viral "Dark Matter"
November 3, 2015
Researchers from the Perelman School of Medicine have used state-of-the-art techniques to survey the skin's virus population, or "virome." The study, published in the online journal mBio last month, reveals that most DNA viruses on healthy human skin are viral "dark matter" that have never been described before. Elizabeth A. Grice, PhD, an assistant professor of Dermatology, served as senior author.
Penn Scientist Reveal 90 Percent of Skin-Based Viruses Represent Viral "Dark Matter"
November 2, 2015
Researchers from the Perelman School of Medicine have used state-of-the-art techniques to survey the skin's virus population, or "virome." The study, published in the online journal mBio last month, reveals that most DNA viruses on healthy human skin are viral "dark matter" that have never been described before. Elizabeth A. Grice, PhD, an assistant professor of Dermatology, served as senior author.
Infection Buster
October 30, 2015
A study led by Vet's Bruce Freedman and Ronald Harty blocked the ability of Ebola and other viruses to exit a host cell and spread by targeting a calcium-signaling pathway.
Microbial Frontier
October 29, 2015
In a Q&A with The Philadelphia Inquirer, Vet's Dan Beiting explained the role of bacteria, fungi, viruses and parasites in maintaining health and causing disease.
Celebrating the Health Care Innovator Award winners
October 27, 2015
The Philadelphia Business Journal named its 2015 Health Care Innovators of the Year, which includes Penn Medicine's L. Scott Levin, MD, FACS, a professor of Bone and Joint Surgery and chair of the department of Orthopaedic Surgery, and Carl June, MD, a professor of Pathology and Laboratory Medicine and director of Translational Research in the Abramson Cancer Center.
Nasal Cilia: The 'Long and Short' of Scent-sation
October 22, 2015
Perfumer & Flavorist covered a study by Minghong Ma, PhD, an associate professor of Neuroscience, that identified patterns in cilia length and function within the mouse nasal cavity. "Since primary cilia are present on almost every cell type in our body and brain, defects in cilia formation and function often cause complex symptoms involving brain malformation, obesity, cognitive deficits, cystic kidney disorder and blindness in addition to anosmia," she said.
Epigenetic Pathway
October 22, 2015
A study by Medicine's Xianxin Hua has found that the relationship of a suppressor molecule and an oncogene explains how breast cancer cells become desensitized to drugs.
October 21, 2015
Research by James Lewis, Frederic Bushman and Gary Wu of Medicine showed that different treatments for Crohn's disease affect children's gut microbes in distinct ways.
Blood Disorder
October 20, 2015
By elucidating the protein complex structure at its root, Mark Greene, Zheng Cal and Douglas Cines of Medicine are developing a new treatment for a serious clotting condition.
Academia, Big Pharma Find Collaboration Fruitful
October 19, 2015
Elizabeth Grice, MD, an assistant professor of Dermatology, spoke with the Philadelphia Inquirer on the new ways that academia and drug companies collaborate on research to generate cash for schools and profitable medicines for manufacturers. Also quoted in the article is Laurie Actman, chief operating officer in the Penn Center for Innovation, who works to spur more corporate engagement.
Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug, Providing New Target for Preventing Relapses, Finds Penn Study
October 13, 2015
A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug, found researchers at the Perelman School of Medicine. "We found that an epigenetic pathway is crucial for growth of HER2+ cells and this epigenetic factor reduces sensitivity of the cancer cells to lapatinib, a HER2 inhibitor," said senior author Xianxin Hua, MD, PhD, a professor of Cancer Biology.
Philadelphia's History of Vaccine Research and Development
October 12, 2015
A Philadelphia Inquirer story on the history of vaccines highlighted several leaders from the Perelman School of Medicine, including the late Robert Austrian, but it also looked ahead. Robert Vonderheide, MD, DPhil, vice chief of Research in the division of Hematology/Oncology at the Abramson Cancer Center, and colleagues are working to create a gene therapy vaccine that could prevent malignancies from forming in healthy individuals who are at heightened risk for developing cancer.
Penn Team Shines a Light on Blood Disorder
October 8, 2015
FierceBiotech mentions a study about a potential treatment for a serious clotting condition by elucidating the structure of the protein complex at its root. The study was led by Mark Greene, MD, PhD the John W. Exkman Professor of Medical Science, and Douglas Cines, MD, director of the Coagulation Laboratory and a professor of Pathology and Laboratory Medicine.
Novel Platform
October 8, 2015
A vaccine developed by David Weiner of Medicine has successfully removed precancerous cervical lesions in half of patients, providing an alternative to surgical treatments.
Dual Role
October 7, 2015
George Hajishengallis of Dental Medicine and colleagues have discovered a protein that inhibits bone resorption and can reduce bone loss associated with severe gum disease.
New Approach to Treating Heparin0induced Blood Disorder Revealed in Structure of Protein-Antibody Complex, Penn Study Finds
October 7, 2015
A potential treatment for a serious clotting condition that can strike patients who receive heparin to treat or prevent blood clots may lie within reach by elucidating the structure of the protein complex at its root, according to new research from the Perelman School of Medicine. The team's work was published in Nature Communications. The team is from the lab of Mark Greene, MD, PhD, the John W. Eckman Professor of Medical Science, including Zheng Cai, PhD, senior research investigator, as well as the lab of Douglas Cines, MD, director of the Coagulation Laboratory and a professor of Pathology and Laboratory Medicine.
Our Microbiome and Our Health
October 7, 2015
The trillions of bacteria and fungi in our bodies make up our microbiome. We're just beginning to understand the critical role this plays in our health. Researchers now believe our "body bugs" influence autoimmune diseases, allergies, obesity, mental health and more. Radio Times embarked on an informative discussion with Tracy Bale, PhD, a professor of Neuroscience in the School of Veterinary Medicine and in the department of Psychiatry in the School of Medicine, Gary Wu, MD, a professor of Gastroenterology, and Frederic Bushman, PhD, a professor of Microbiology.
Exploring New Horizons in Hematologic Oncology
October 6, 2015
In continuing coverage, Oncology Central research from the lab of David Roth, MD, PhD, chair of the department of Pathology and Laboratory Medicine, on a DNA-cutting mechanism that sometimes malfunctions, leading normal immune cells to turn into blood cancers.
Cancer Immunotherapy: The Cutting Edge Gets Sharper
October 1, 2015
Scientific American spoke with Carl June, MD, a professor of Pathology and Laboratory Medicine and director of Translational Research in the Ambramson Cancer Center, for an article focusing on the latest advances — and remaining questions — in the field of immunotherapy. "There are 300 kinds of cancer at least and they're each goingt to have different issues." June said. "I think we have enough tools that we can plot a course."
Penn-developed, DNA-based Vaccine Clears Nearly Half of Precancerous Cervical Lesions in Clinical Trial
September 30, 2015
Using a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
September 23, 2015
A study led by Alexander Huang, an Abramson Cancer Center fellow, demonstrates how PD-1 drugs work in melanoma patients, putting a potential biomarker within reach.
CRI Irvington Postdoctoral Fellows: A Passion for Science
September 22, 2015
Postdoctoral fellows are the engine of biomedical research. Hear what it's like to be a Cancer Research Institute (CRI) postdoctoral fellow from those who have devoted their lives to the pursuit of basic research in cancer immunology. Featuring Beth Stadmueller, PhD, Roy Maute, PhD, Matthew Gubin, PhD, Paola Betancur, PhD, Kristen Pauken, PhD, E. John Wherry, PhD, and Ellen Puré, PhD.
Established in 1971, the CRI Irvington Postdoctoral Fellowship Program is the oldest of CRI's grant initiatives. To date, CRI has supported more than 1,300 fellows and invested more than $115 million in their training at laboratories all over the world. CRI is the only nonprofit organization devoted exclusively to funding research in the areas of cancer immunology and immunotherapy, with the goal of developing more effective immune-based treatments for all cancers.
Doctors Take Shot at Keeping Cancer Away
September 21, 2015
Robert Vonderheide, MD, DPhil, vice chief of research in the division of Hematology/Oncology at Penn's Abramson Cancer Center, is quoted in a Houston Chronicle article on the latest studies investigating cancer vaccines. His group recently launched an early-stage, DNA immunotherapy trial trying to prevent recurrence in cancers of the pancreas, lung and breast.
Sense of Smell
September 18, 2015
Sensitivity to odors depends on the length of the sensory cilia and their location in the nasal cavity, according to research by Med's Rosemary Lewis and Minghong Ma.
American College of Rheumatology Educational Tracks
September 17, 2015
The American College of Rheumatology (ACR) Annual Meeting sessions are based on educational tracks based on specialty or area of interest, ACR Daily News reports. In the business administration track, a senior member of Congress will provide perspective on the Patients' Access to Treatments Act, which Sharon L. Kolasinski, MD, a professor of clinical medicine and director of rheumatology at the Penn Musculoskeletal Center, says "will help support change in the tiering of medications."
Lafayette student receives a kidney from a stranger
September 17, 2015
The Allentown Morning Call spoke with Peter Abt, MD, an associate professor of Surgery in the division of Transplant Surgery, and the surgeon who operated on Penn patient Andrea Samson, about her case and some of reasons why people donate. Samson, a 20 year-old college student who had dealt with kidney failure her entire life, received a kidney from an anonymous donor in July. Abt, who performed both of Samson's transplant surgeries - the first was a kidney donation from her father at age 15, which her body ultimately rejected - noted that many individual donors have a history of volunteerism, and choose to donate their organs simply to help others -- even strangers.
Editing Errors
September 15, 2015
A study by David Roth of Medicine shows that blood cancer can develop in animals when enzymes that cut and paste segments of DNA hit an "off-target" spot on a chromosome.
Enzyme Replacement Works in Rare Lipid Disorder
September 11, 2015
In this week's New England Journal of Medicine, researchers report results of a trial showing the efficacy of a new enzyme-replacement therapy for Lysosomal acid lipase deficiency. In an accompanying editorial, Daniel J. Rader, MD, chair of the department of Genetics, noted the great potential of this therapy. Quoted in MedPage Today, Rader says there is still a need for a larger, longer-term study to confirm these results.
Blood Cancers Develop When Immune Cell DNA Editing Enzyme Hits Off-target Spots in the Genome, Penn Animal Study Finds
September 11, 2015
Researchers from the Perelman School of Medicine have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models. David Roth, MD, PhD, chair of the Department of Pathology and Laboratory Medicine, served as senior author of the study which was published online this week in Cell Reports.
Novel Approach
September 10, 2015
A study by Med's David Porter and Carl June shows that personalized cellular therapy for chronic lymphocytic leukemia has resulted in long remissions for some patients.
PCSK9 Inhibitors: Now That We Have Them, What Do We Do?
September 9, 2015
Following the FDA approval of PCSK9 inhibitors for lowering LDL levels, MedPage Today quoted Daniel J. Rader, MD, chair of the department of Genetics in the Perelman School of Medicine, on the preexisting need for this type of medication. Rader noted there is "a big pent up demand for these drugs," particularly for those with coronary artery disease, familial hypercholesterolemia, and those who have trouble tolerating statins.
Penn Reports Long-Term T-Cell Therapy Results
September 8, 2015
In continuing coverage, David Porter, MD, a professor of Hematology-Oncology and director of Blood and Marrow Transplantation in the Abramson Cancer Center, is quoted in a Philadelphia Inquirer story detailing his team's latest results using an investigational personalized cellular therapy to treat chronic lymphocytic leukemia. Bill Ludwig, the first patient to receive the therapy, recently marked five years cancer-free, and is also featured in the article.
Breathing Easy
September 4, 2015
Research led by Vet's Carolina López found a viral product that promotes a strong immune response against respiratory syncytial virus, a threat to infants and the elderly.
Blood Cells, Honed in the Lab to Kill Cancer, Lead to Five-Year Remissions
September 3, 2015
The Abramson Cancer Center team whose work led to the first successful and sustained demonstration in the use of genetically engineered T cells to fight cancer reports this week that two leukemia patients who were among the first to receive this investigational therapy remain in remission five years later. The research, published in Science Translational Medicine this week, is led by David Porter, MD, a professor of Hematology-Oncology and director of Blood and Marrow Transplantation in the Abramson Cancer Center, and Carl June, MD, a professor of Pathology and Laboratory Medicine and director of Translational Research in the Abramson Cancer Center. "The patients in this trial have largely failed all other conventional therapies and really had really, very few treatment options," Porter told WHYY Radio. "Nothing was really working for them."
Results From the SERVE-HF Study
September 2, 2015
At the European Society of Cardiology meeting last week, MedPage Today conducted a video interview with Mariell Jessup, MD, a professor of Medicine, associate chief of Clinical Affairs in the Division of Cardiovascular Medicine, and medical director of the Penn Medicine Heart and Vascular Center. Jessup commented on the SERVE-HF trial and the treatment of sleep-disordered breathing with adaptive servo-ventilation in patients with chronic heart failure.
F.D.A. Approves Repatha, a Second Drug for Cholesterol in a Potent New Class
August 31, 2015
As the F.D.A. approves the second drug designed to lower LDL levels for those whose high cholesterol and heart disease cannot be controlled with statins, the New York Times quoted Dan Rader, MD, associate director, Institute for Translational Medicine and Therapeutics and chief, division of Translational Medicine and Human Genetics, on the benefits of lower LDL levels in lowering the risk of heart attack and stroke.
Carter's Cancer Fight Reflects Change in Treatment of Elderly
August 25, 2015
Lynn Schuchter, MD, chief of Hematology/Oncology at Penn's Abramson Cancer Center, and Robert Lustig, MD, a professor of Radiation Oncology, are quoted in a Philadelphia Inquirer story on the recently announced cancer treatment plan for Jimmy Carter, who will receive radiation plus the immunotherapy pembrolizumab for his metastatic melanoma. "I definitely think it's a reasonable treatment to be pursuing and potentially could really help him," Schuchter told the Inquirer.
High Priority
August 25, 2015
Med's David Weiner and Karuppiah Muthumani have found that a novel synthetic DNA vaccine can induce immunity against Middle East respiratory syndrome in animals.
Internal Clock
August 24, 2015
According to a study by Medicine's Garret Fitzgerald, Frederic Bushman and Xue Liang, circadian rhythms and gender influence the microbiome make-up of mammals.
Synthetic DNA Vaccine Against MERS Induces Immunity in Animal Study, Penn Researchers Find
August 19, 2015
In continuing coverage, WHYY Radio and other outlets ran stories about a synthetic DNA–based vaccine targeting the Middle East respiratory syndrome coronavirus (MERS-CoV). Lead author David Weiner, PhD, a professor of Pathology and Laboratory Medicine was quoted.
Jimmy Carter to Undergo Radiation and Immunotherapy
August 21, 2015
Lynn Schuchter, MD, chief of Hematology/Oncology at Penn's Abramson Cancer Center, and James Metz, MD, chair of Radiation Oncology, were featured on CBS3 for a story on Jimmy Carter's cancer announcement. Carter revealed that he will receive both radiation and a newer immunotherapy drug call pembrolizumab to treat his melanoma, which has spread to his liver and brain. "The idea is that radiation will cause the death of tumor cells, cause an immune response, and with that drug, it will actually make the immune system work better," Metz told CBS3. Schuchter also went live on CBS3 and FOX29 to discuss the diagnosis and treatments.
Delaware Woman Receives Kidney of Father Killed in Car Accident
August 17, 2015
In continuing coverage, ABCNews.com reports on a Delaware woman who needed a kidney transplant for almost two years, and now has her father's kidney after he recently died in a car accident. Penn patient Stacey Knox traveled to HUP earlier this month to receive her father's kidney, her husband said, adding that the transplant was successful, and that she's recovering and being monitored. "It's certainly a bittersweet story, but I think this is one of those opportunities where a parent gets to make a lasting and final gift to their child," Knox's surgeon Peter Abt, MD, surgical director of Kidney Transplantation, said.
T cell Receptor Therapy Achieves Encouraging Clinical Responses in Multiple Myeloma
August 11, 2015
In continuing coverage, the Baltimore Sun covered a recent study investigating a new T cell receptor therapy in multiple melanoma patients from researchers in Penn's Abramson Cancer Center. This time, the team, led by Carl June, MD, a professor in Immunotherapy in the department of Pathology and Laboratory Medicine, and Edward Stadtmauer, MD, a professor of Medicine and section chief of Hematologic Malignancies, modified T cells to attack cancer cells expressing NY-ESO-1. The study was also covered by Oncology Nurse Advisor and the ASCO Post.
Parasite Defense
Agust 5, 2015
After infection with leishmania, T cells reside in the skin to prevent future attacks, Vet's Philip Scott found. The work could inform vaccine development.
Seminar Research
August 5, 2015
In recognition of her influential contributions to the field of hematology, Medicine's Nancy Speck was awarded the 2015 Henry M. Stratton Medal for Basic Science.
Vitamin D for Pancreatic Cancer
July 27, 2015
In continuing coverage, ABC 30 in Fresno, Calif., reported on a clinical trial at the Abramson Cancer Center investigating the use of vitamin D in combination with chemotherapy for pancreatic cancer patients. This first in-human trial is being led by Jeffrey A. Drebin, MD, PhD, chair of Surgery, and Peter O'Dwyer, MD, a professor of Hematology/Oncology, and is funded by the Stand Up to Cancer initiative.
T-Cell Receptor Therapy Shows Promise for Myeloma
July 27, 2015
Results from a clinical trial investigating a new T cell receptor therapy demonstrated a response in 80 percent of multiple myeloma patients after undergoing autologous stem cell transplants, according to a new study from Abramson Cancer Center researchers published in Nature Medicine, reports WHYY Radio and Fiercebiotech. This time, the team, led by Carl June, MD, a professor in Immunotherapy in the department of Pathology and Laboratory Medicine, and Edward Stadtmauer, MD, a professor of Medicine and section chief of Hematologic Malignancies, modified T cells to attack cancer cells expressing NY-ESO-1, an antigen found in nearly 60 percent of multiple myelomas. Genetic Engineering & Biotechnology News, Medical Daily, and BioScience also covered the study.
Man Survives Cancer and Heart Transplant, then Bikes Coast to Coast
July 23, 2015
Penn Medicine heart transplant patient, Derek Fitzgerald, completed the final leg of his cross country bike tour to raise money and awareness for the Leukemia and Lymphoma Society, stopping through Penn yesterday for a ceremony featuring words from Mariell Jessup, MD, an associate chief of clinical affairs in the division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center and Chi Van Dang, MD, PhD, director of the Abramson Cancer Center. Derek and his team finished is his 44-day journey yesterday afternoon in Avalon, NJ. This was covered by CBS3, WIP Sports Radio and NBC10.
Investigational T-cell Receptor Therapy Achieves Encouraging Clinical Responses in Multiple Patients, Penn-led Study Finds
July 21, 2015
Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT). The results of the study were published this week in the journal Nature Medicine from researchers at Penn's Abramson Cancer Center, including senior author Carl H. June, MD, the Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine and director of Translational Research in the ACC, the University of Maryland School of Medicine, and Adaptimmune Therapeutics plc (Adaptimmune).
Clinical Response
July 22, 2015
Research by Carl June and Edward Stadtmauer of Medicine has found that new T-cell receptor therapy is both safe and effective for patients with advanced multiple myeloma.
ECG Metrics May Predict Cardiac Deaths in CKD Patients
July 15, 2015
HealthDay (via Doctors Lounge) reports that certain electrocardiographic measures may improve prediction of cardiovascular death in patients with chronic kidney disease, according to a study led by Rajat Deo, MD, an assistant professor of Medicine, and published in the Journal of the American Society of Nephrology. Medscape and Health Management also covered the study.
FDA Approves Heart Failure Drug that Comes with Survival Benefit
July 13, 2015
In continuing coverage, TCTMD reports on the FDA's recent approval of Entresto for the treatment of heart failure. Mariell Jessup, MD, associate chief of clinical affairs in the division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center, says that among the reasons the approval is important is that "the success of this drug has seemingly opened the floodgates of research into other potential heart failure drug investigation, making it a very exciting next chapter in the heart failure arena."
The Summer of Cardiology Blockbusters
July 9, 2015
Medpage Today reports that the recent FDA approval of heart failure drug Entresto and the pending approval of two PCSK9 inhibitors this summer has reinvigorated the search for further advances in cardiology. "Already there has been a renewed sense of interest and excitement from many pharmaceutical companies taking another look at heart failure therapy," said Mariell Jessup, MD, associate chief of clinical affairs in the division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center.
Novartis "Breakthrough" Heart Failure Drug Wins Speedy Approval
July 8, 2015
The first drug to demonstrate a mortality benefit when compared with enalapril for heart failure -- Entresto, previously known as LCZ696 -- received FDA approval Tuesday, according to Medpage Today. Cardiologists, including Mariell Jessup, MD, associate chief of clinical affairs in the division of Cardiology and medical director of the Penn Medicine Heart and Vascular Center, are calling it a potential game changer because "it represents a new class of drug, which may have a meaningful impact on the trajectory of disease in many patients."
Groundbreaking Specialty Drugs Come with High Costs
July 8, 2015
A Food and Drug Administration advisory group recommended in June that the agency approve a new drug, Praluent, from Sanofi and Regeneron Pharmaceuticals. If approved, it will be the first in a new class of blockbuster medicines that sharply lower levels of cholesterol, the leading cause of heart disease. But groundbreaking specialty drugs often come with a huge price tag. "If these drugs are really given to the number of people who are candidates for them, the cost will be astronomical," Daniel J. Rader, MD, chair of the department of Genetics and director of the Preventive Cardiovascular Program, told U.S. News & World Report.
Stayin Active in the Lab
July 7, 2015
David Weiner, PhD, a professor of Pathology and Laboratory Medicine, comments in The Scientist about continuing research after retirement. Weiner hosted retired clinical dermatologist Henry Maguire as a full-time postdoc in his lab from 1997 to 2011. In retirement, Maguire's expertise was an invaluable asset to the gourp, Weiner says. "He always challenged us: What is the importance of this work? What is the point of doing this? He made things kind of slow down, took you out of the rat race, and gave you time to think about things in an elegant and important way."
Higher CD8 T-cell Dose from Younger Donors Improves Transplant Outcomes
July 7, 2015
HemOnc Today reports on a new study from Abramson Cancer Center researchers that found that older patients undergoing allogeneic stem cell transplants who received stem cells from younger, unrelated donors with higher numbers of so-called killer T cells (CD8 cells) had significantly reduced risk of disease relapse and improved survival. The study, co-authored by David Porter, MD, director of Blood and Marrow Transplantation in the ACC, was published in the Journal of Clinical Oncology.
The Work Towards a Cure
July 7, 2015
James Hoxie, MD, director of the Penn Center for AIDS Research, was featured in a Hellio.com video talking about the advances in HIV, including gene therapy technology that kept the virus at bay in some patients taken off medications. "Those of us in the field, especially those of us who have been in it since the beginning, when HIV was a new disease, feel empowered by what we've accoplished, " Hoxie said. "That can only make us hopeful for what is ahead."
PCSK9 Inhibitors: The Needle, the Cost, the Barriers
July 2, 2015
On June 10, an FDA advisory panel voted 11-4 in favor of approving PCSK9 inhibitor evolocumab (Repatha), with most panelists saying they saw no need to wait for the ongoing cardiovascular outcomes trial data. Daniel Rader, MD, director of preventive cardiology, predicted that rigorous documentation of statin intolerance would be required for insurance coverage in the clinic, he told MedPage Today.


text: Doug Finke State Week In Review: October 18, 2013 By Sean Crawford • Oct 18, 2013 On this edition of State Week in Review, our panel previews the upcoming fall session of the Illinois General Assembly. From pensions to same sex marriage to gun crime sentencing, we discuss what may or may not occur. Also, the impact of the federal shutdown on state government. Our guest this week is Gatehouse Media's Doug Finke. Dollars for Dialing: Should the phone companies win the competitive edge in a new tech era? By Doug Finke • Apr 1, 2001 Daisy Langston Juarez In early February, an organization calling itself Connect Illinois convened a news conference in the state Capitol pressroom to brief reporters on telecommunications issues. The event drew a large crowd of speakers. There were three state lawmakers, two chamber of commerce presidents and members of three community organizations. Oddly, there were no official representatives of telecommunications companies.

subset: commoncrawl


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I was licensed in 1976 as WN4PBW. My dentist (Sandy - WA4PBX) and I were both frustrated CB'rs and at the urging of our "Elmer" Cal Neff (K4JSR) at the Lafayette Radio Store in Buckhead, we took his novice class and started in this hobby.
I own a condominium in northwest Atlanta and my station is somewhat stealthy. My home is on the ground floor and an end unit. My rig is an Icom 765 and an Ameritron AL-811 amplifier with the 10M modification. Hidden up in the woods behind my building is a SteppIR Vertical with radials. In the winter, one can spot the tall straight stick if you look carefully. In the summer with the plant growth, the stick is really difficult to find.The station has been installed since 2006 and so far, no one has complained!
I'm a pilot instructor for Delta Air Lines here in Atlanta and qualified on the Boeing 737-200 and the McDonnell-Douglas MD-88/90. I also trained on the Boeing 777 but moved back to the MD-88/90 program. In addition to my pilot certificate, I have a Certified Flight Instructor certificate with Airplane/Single engine/Multi-Engine/Land and instrument instructor endorsements. As an honoree of the "Chairman's Club" at Delta, I was "given" MD-88 ship 9020 with my name emblazoned next to the door. The photograph above was shot in the cockpit of "my" plane.
While in college, I got my private pilot certificate. During my stint in the United States Air Force, I received more endorsements and let the GI Bill help me out during my enlistment and after my honorable discharge. I also paid for some of my flying lessons with photography and have professionally photographed NHL hockey, NFL football and was a personal photographer for a major US politician. My Nikon D-700 travels with me all the time.
I'm a 99% Mac user having given up on Windoze years ago. I have one PC to electronically run my home automation system and my logging program. The other computers are an iMac Retina, Macbook Pro Retina, iPad Air Retina, and iPhone. The Macs are equipped with Adobe Photoshop C2014 and the iPad with a photo editor app that I can use on the road.
I was one of the first instructors to convert to the iPad for pilot briefings and simulator useage. Gotta love the Mac. Once you buy Mac, you never go back!
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Got a minute?
Got a minute?
Evan Rodd, PayScale
According to PayScale's 2014 Compensation Best Practices Report, hiring and talent retention are hot topics this year for companies of all shapes and sizes. In an effort to balance compensation budgets and navigate the widening skills gap, hiring managers, recruiters and company leaders are starting to reevaluate the criteria many have traditionally relied on.
Crystal Spraggins
PayScale's 2014 Compensation Best Practices Report noted that 50% of companies are having a difficult time filling skilled positions.
The finding was not too surprising given all we've heard about the skills gap in the last few years. However, the difficulty in finding suitable employees can't be attributed solely to job seekers and their qualifications, or lack thereof. I've spoken with enough hiring managers to know that many are woefully under-skilled when it comes to interviewing—not that it's all their fault. The interviewing process is not immune to myths, and some of these can get in the way of a company recognizing talent, even when it's staring the company in the face.
Tess C. Taylor, PHR, The HR Writer
It's a fact. Each year businesses face too late what happens when employee morale drops and the best begin to leave for greener pastures. This most often occurs when the leadership team forgets that there is a fine line between recruiting and retaining high performance candidates. It's a sad state of affairs that is completely preventable, with the right efforts and planning.
Jessica Miller-Merrell, blogging4jobs
One of the hardest things to overcome when you're attempting to hire employees is doing so with no budget. For many small and non-profit organizations, it's a reality that there's no money to dedicate to recruiting. Whether it's because there just isn't enough to go around or because you're only responsible for hiring for a few positions and money is allocated to larger scale hiring, many of us are faced with doing the impossible: hiring employees on a $0 budget.
Evan Rodd, PayScale
If you've ever hired someone, chances are you've been tempted to run a quick Google search, or comb social media for additional information. This can be a good way to evaluate talent, and provide insight into a potential hire's professional demeanor. While helpful, this new era of decreased privacy can be daunting for employees and employers alike – we want to present a professional image, and we want to hire people who present such an image. By the same token, we want to avoid that creepy feeling that comes from excessive snooping, worried that our search for misconduct could become a self-fulfilling prophecy. In an age where almost every aspect of our lives is willingly documented by social media (if not, the potential is there), how do we exercise our right to free speech and self-expression while still maintaining a sense of professionalism?
Crystal Spraggins, SPHR
It's amazing.
The Department of Labor reports a current unemployment rate of 7.3% (and some say the percent is really closer to double digits, once you factor in people who've simply stopped looking for work), but still employers can be heard all day long talking about how they can't fill jobs.
We hear a lot about the various ways social media blunders can cost you a job, but that doesn't mean you should keep your Tweets completely private. On the contrary, many organizations rely on social media to help them find qualified job seekers who may not even be away of available positions. As long as your social media presence is thoughtful and well curated, you could actually increase your chances of landing a job.
There's no denying that the skills gap is a growing concern for employers, but there may be some dispute as to when it begins. Common misconceptions could be that the skills gap occurs during the college years, as students aren't equipped with the necessary experience to enter the workforce qualified to do a job. Some may also think it begins as workers gain more years of experience but fail to maintain their knowledge of current technologies, processes or industry knowledge. However, the skills gap actually begins in high school, far before a worker even declares a major or takes on their first full time job.
Nearly every company in every industry has been challenged by a skills gap in their workplace. Whether it's a significant gap, such as the inability to fill demanding positions, or more minor, such as the need for an employee to become more skilled in creating spreadsheets, the skills gap can be felt nearly anywhere there are employees. Companies use a wide variety of resources to close the skills gap, from external recruiting, to internal training and mentorship programs, but there's another resource that isn't often used but is highly valuable: online education.
The skills gap is reported as being a top concern for employers, but there may be more there than meets the eye. While nearly half of all employers report having a difficult time hiring employees to fill positions, many don't discuss the hidden reasons behind the difficulty of hiring. The skills gap is real and it certainly exists, but there tend to be a lot of myths surrounding it. Here, we break some of those myths down and talk about what the skills gap really is and isn't.
Laleh Hassibi, PayScale
We've been talking about purple squirrels a lot lately at PayScale but what if your organization has a Squirrelcorn – a totally unique job that is the hybrid of two different jobs? How would you price that job? Or what about the situation where some of your jobs are moving faster (or slower) than the general market? Are you able to stay on top of those jobs to ensure you're keeping up with the market and paying employees the right amount? Two new exciting features of PayScale's software can help you with these situations.
For many companies, it's the time of year when recent grads and summer interns turn into full-time employees. Bright and shiny, with the new business card holder they got for graduation, they're now a part of your team. While you've probably seen plenty of new entry-level employees come and go over the years, you could play a part in retaining these new team members.
An entry-level employee may be new to your company, buy they still provide value on a day-to-day basis. In fact, replacing even an entry-level employee can cost anywhere from 30 to 50 percent of their salary and retaining them can help to decrease your company's turnover over time. So how can you increase the commitment level of this group of employees? Take a look at these three tips:
Laleh Hassibi, PayScale
Take the PayScale Challenge! Are you searching for a purple squirrel – you know, that elusive candidate who has all the qualifications and experience your job position requires? Or maybe you just lost a valuable employee to a competitor. If you're like most organizations, you spend between 30% and 50% of revenues – totaling millions of dollars a quarter – on compensation. Getting compensation right not only means having control over the bottom line, but getting and keeping star employees.
Evan Rodd, PayScale
Let's face it – we are living in a mobile world where convenience and speed tend to dictate most of our decision-making. There seems to be an app for, well, almost everything, and that doesn't seem to be changing any time soon. Not only do we have multiple apps for calling car services, or recognizing music, we have a variety of different platforms that allow us to access apps (and the information contained within) at almost any moment.
Jessica Miller-Merrell, blogging4jobs
Last year, companies spent 12 percent more on training employees than in recent years. This can certainly be taken as a good sign, showing that companies are investing in their workforce and that the improving economy is allowing them the funds to do so, but it also speaks to the growing concern of the skills gap in America.
Tess C. Taylor, PHR
Jessica Miller-Merrell, blogging4jobs
In part one of this thee part series, "What Makes a Great Hiring Manager," I talked about all the different hats that a hiring manager needs to wear. Interviewer, recruiter, networker, relationship builder – the list goes on and on. What I didn't mention in part one of What Makes a Good Hiring Manager is that the difficult part about wearing all these hats is that to be truly successfully, you need to wear them all exceptionally well.
There are some moments that just stick with you. For me, one of those moments was when colleagues from other departments at the company I was working were discussing who had the worst job in the company. The overwhelming majority agreed that I took that title. They talked about how difficult it must be to anticipate staffing needs and constantly keep a pipeline of potential employees at the ready.
While each of us has probably interned for free at one point in our lives, we also all know how much it sucks. As an intern, you're not only the low man on the totem pole, you're probably also working your butt off trying to impress your boss and not getting paid to do it. So what gives with the unpaid internship gig?
Laleh Hassibi, PayScale
U.S. First
Lady Michelle
Obama urged companies to hire more veterans last week. The unemployment
rate of those who
served in Iraq and Afghanistan is nearly two points higher than the
national average, at 9.4 percent. While it's admirable to hire veterans for
emotional reasons, there's another really good reason to hire a veteran — their


text:
sf forage
Photos: SF Underground Market
By Joseph Schell on May 23, 2011 8:30 AM
Scenes of the City: Forage SF-Edible Wild Food Walks
By Joseph Schell on March 01, 2011 10:00 AM
For this week's "Scenes of the City," we tagged along on an edible food forage in Golden Gate Park. Instructor Kevin Feinstein of Forage SF guided a small group of students through areas of Golden Gate Park, all the while pointing out edibles and informing the class how to best harvest, prepare and consume the plants. While foraging in Golden Gate Park is illegal, it's not illegal to learn about what we can eat in the city around us.
All copy and photos by Joseph Schell


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The Periodic Table shows nature's variety at its most basic and extraordinary. Each element presents a unique combination with its own distinct properties. Inspired by this rich variety, Foundry Cigars created Compounds, Elements, and Musings as a study in contrasts and complexity. By combining tobaccos chosen from all over the world, now you can discover a range of distinctive blends (all undisclosed) in these VERY AFFORDABLE cigars with some of the coolest bands, too. Order some now!
These are great, I don t know what s in it or what it s made of, but it is a very enjoyable smoke. Sometimes you just need to take the plunge and try something new, and these Vanadiums are a prime example, I m so glad I did. The flavors remind me of Acid cigars, cloves, vanilla, cinnamon and other sweet spices, mild to medium bodied and smooth, tasty from start to finish, hard to put down. I don t know whether or not they are infused like Acid cigars, but they sure do pack some delicious and enjoyable flavors. Don t miss out on trying these.0 1
OK, I am a gimmick kind of guy. I was impressed with the V presentation of the cigar box, and although I have smoked Foundry sticks previously and was not terribly impressed, I purchased the box anyway. After letting the sticks age in my humidor for 18 months, I finally tried two of them. Construction was very good. Flavor was not intense, but different than many of the other Foundry s I ve smoked, it actually had flavor; and for that I give it kudo s.0 0


text:
Our green tea is all hand-sourced from China and Japan, perfected by masters with generations of knowledge in producing nothing but the very best.
Offering vibrant grassy flavours, a sublime natural sweetness and a satisfying silky texture, Green Tea has been a connoisseur drink in the East for centuries. Sadly many have only tried poorer quality think of it as a bitter and dull health-drink.
Spring is an exciting place at JING when we travel to China to find the freshest, most celebrated teas available. Our Dragon Well, Anji Green and Organic Jade Sword are at their very best in spring.
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text:
Big 12 baseball notebook: Teams remember tornado victims
Oklahoma coach Sunny Golloway said the Big 12 tournament pales compared to what residents in Moore are going through. The tournament was delayed for 3 1/2 hours because of early morning rain showers.
"When I woke up about 6:15 (a.m.) and I heard rain hitting the window I was sick to my stomach because I thought to myself, 'How are they going to continue the cleanup?'" Golloway said. "It wasn't about what's going to happen to baseball. Being very candid I could care less what happens to baseball ..."
"Mayor Mick Cornett and his words before the game were a tribute to Oklahoma. But I also thought it was a great learning opportunity for the athletes on the field to hear his words of encouragement and why we're playing ... And he had a pretty good fastball."
Oklahoma players wear special T-shirts
OU players wore sky blue T-shirts to the postgame news conference that they wore under their jerseys. The shirts featured the state of Oklahoma with the word HOME, the O replaced by the logo on the state flag.
"It's kind of a haven for us to be able to come out and play baseball but your mind never gets off it," Golloway said. "The helicopters are going over so we're thinking about our shirts, which make a statement for themselves.
"This is our home. Those are our family, those are our friends. My grandson is a Moore resident with my daughter and son-in-law so it really hit home."
Big 12 baseball underrated?
The theme all week from Big 12 coaches has been just because the conference doesn't have a dominant team, it doesn't mean it's a down year. Baylor coach Steve Smith said because of lower than usual RPIs, a Big 12 team might be seed fourth at a regional.
"That would be somebody's nightmare if they think there's a four seed coming out of this league," Smith said. "I would have even said the same thing about Texas (that didn't qualify for the Big 12 tournament).
"The question I would ask is would Texas have finished last in the SEC, the ACC or Pac-12? I think the answer is 'Absolutely not.' The league is really good. It's really good on the mound. You can't make these (NCAA bids) off a piece of paper. The RPIs do not reflect the quality of play in this league."
Jayhawks end 6-game skid
Kansas (32-24) entered the Big 12 tournament on a six-game losing streak after winning six in a row. The Jayhawks opened pool play Thursday night with a 7-2 win over West Virginia.
"After we won a couple against in-state rival Wichita State and swept Baylor, I thought we played our way into the (NCAA) tournament," said KU coach Ritch Price. "Then we lost two tough ones at Kansas State to put us on the bubble.
"We knew we played our way out with those two devastating losses last week at Utah after finals week. We came here with the goal to play our way back in."


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Techakko|January 30 2013 |Mobile Apps, Fun, Games, Mobile Games
From Cheese is a cool new puzzle game by Spin Vector for Android & iOS devices. Basically you will need to help a mouse in the game to collect cheese. There are 48 mind twisting puzzle levels in the game with cartoon style quality graphics. Game is simple to play but as you go further you will find it hard to get all 3 stars in a level. In each level mouse sits at the starting point of level and the cheese is on the end point. You will need to solve the maze type puzzle and draw a path for the mouse to get the cheese.
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VanMoof's SmartBike brings smarts to a bicycle
Qualcomm's All-Ways Aware hub improves contextual
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HTC 10 vs HTC 10 Lifestyle vs HTC One M9 Plus: wha
Rumour Zone: what to expect from the OnePlus 3


text:
I made a great slideshow using MS photostory 3, output file type 'wmv';
It should normally play on wmplayer.exe on most XP machines.
The following line will run perfectly on my pc from the START, RUN spot:
wmplayer "C:\Documents and Settings\MyPC\My Documents\My
Videos\PhotoStory1_best_trip.wmv" /fullscreen
I want to distribute copies of the CD to people with XP machines and
have an autorun.inf file on the CD to automatically start the 'wmv' slideshow
The autorun.inf I came up with looks like this:
shellexecute="PhotoStory1_best_trip.wmv /fullscreen"
This launches Windows Media Player and the correct file on the CD, but
does not kick in the full screen option.
I have tried different OPEN, SHELLEXECUTE, and even batch file
combinations and cannot get the autorun.inf to function like the RUN
I do not want the end users to have to fumble with or bother with figuring
out how to set the player to fullscreen (while they are also missing the first
minute of the slideshow.)
Any solutions should be for the standard XP SP2 load and should be known
to work for exactly what I am talking about. Thanks :)


text:
Damn that must have been one hell of a wedding!A bride who stole £200,000 from her employers to pay for a lavish wedding has been jailed.
Part-time accounts assistant Kirsty Lane, 30, transferred the funds from Pure AV's bank account into that of her and her future husband, Graham.
The fraud was discovered shortly after the pair's wedding at the Great Hall at Mains, near Blackpool in January 2011.
Lane, of Lewis Close, Adlington, Lancashire was sentenced to 20 months in prison at Preston Crown Court.
She stole about £122,000 from the Leyland company, which installs audio-visual equipment, by putting in fake invoices, marking them as paid and then depositing the money into her own account.
She also diverted about £70,000 through her husband's account, which she told him were savings, salary and bonuses. About £6,000 was transferred into a third account.
Company director Peter Sutton said Lane had cost the firm about £300,000, due to tax and VAT payments, and put the "livelihoods of 20-plus people" in jeopardy.
'Lavish wedding'
Police said Lane began working for Pure AV in May 2007 and started siphoning money into her account in December 2008.
A spokesman said the offences had continued until she left the company for her wedding on 23 January 2011 by which time she had made a total of 122 fraudulent transactions.
The Great Hall at Mains Lane spent a large proportion of the money on a lavish wedding at the Great Hall at Mains
He said a large proportion of the money had been used to fund her "lavish wedding" which included a free bar, musicians, fireworks, a magician and face-painting.
He added that Lane had also used the cash to pay for home improvements and items such as a large television, a Tag Heuer watch, an iPod, compact mirrors and car keys covered in Swarovski crystals and personalised car registration plates.
He said she had "abused her position of trust to steal from her employer and fund a lavish lifestyle".
Speaking in Lane's defence, Amanda Johnson said she was a woman of good character who suffered from low self-esteem and the offending coincided with the time she met her husband.
"She felt that money and the trappings that money could buy would make her a more attractive proposition," she said.
She said Lane thought she could "make herself more attractive to him by having money and being able to spend it on gifts and holidays".
'Cynical exploitation'
Passing sentence, Judge Pamela Badley said the "modest" first amounts of cash Lane stole from the company had escalated and gone on to fund a luxury lifestyle.
Judge Badley said her behaviour had been "fraudulent from the outset" and told her she had taken part in a "cynical exploitation of the small company for which you worked".
Speaking after sentencing, Mr Sutton said Lane had been "a trusted member of the team and she had been in that position for a number of years".
He said she defrauded the company in a complex way and there had been no obvious "digital trail".
"We just wanted it over. It's the end of a traumatic time in our existence and the legal system has prevailed," he said.
Graham Lane was found not guilty to one count of money laundering at Preston Crown Court on an earlier date
i must say though what a nasty and selfish women, as said in the article she's put at risk the futures of many of her former co-workers from her selfish theft of a small companies money and in times like these £200,000 is a lot of money. I hope she gets a lengthy sentance for this one.
Bride steals £200,000 from company to fund her 'lavish wedding'
|Posted on
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Oh dear me!
She just wanted to be a princess for a day, bless her!
Greedy woman. Looking at the size of her, I'm not surprised. Women like her shouldn't be able to feel like a "princess" for a day. She's no princess.
How selfish
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- 2 followers
She stole from her bosses and then invited them to her wedding that they were unknowingly paying for! You have to admit, she has a strong sense of irony.
Selfish and disgraceful
(Original post by Dreamweaver)
She stole from her bosses and then invited them to her wedding that they were unknowingly paying for! You have to admit, she has a strong sense of irony.
Why spend that much on a wedding :/
I'd have decent nice cheap family wedding over that. Well, i have.
The irony that her boss had got her a wedding gift too :') on a serious note, it's absolutely disgusting that people lost their jobs because this greedy cow wanted a big wedding though!
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woman be crayzee!
(Original post by im so academic)
Greedy woman. Looking at the size of her, I'm not surprised. Women like her shouldn't be able to feel like a "princess" for a day. She's no princess.
She stole £200,000 but that doesn't buy her class. Neither does it buy her beauty.
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Is this woman really a threat to the public?
Not that I'm condoning her behaviour, but I don't think putting her in prison really serves all that much good.
Yet she was drinking Tango.
OfflineReputationRep:(Original post by Dreamweaver)
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She stole from her bosses and then invited them to her wedding that they were unknowingly paying for! You have to admit, she has a strong sense of irony.
OfflineReputationRep:(Original post by im so academic)
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Greedy woman. Looking at the size of her, I'm not surprised. Women like her shouldn't be able to feel like a "princess" for a day. She's no princess.
On topic. She's a bloody idiot. That 200K is nothing in the long term
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At least she had the day of her life.
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Looking at the size of her, she must have spent it all on cream cakes.
Oh my god
I don't understand that why most of the women want to spend too much on their weddings. Haven't they heard of savings for rainy days?
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STARmeterSEE RANK
Down 16,470 this week
RJ Konner
RJ KONNER - Actor, Producer & Senior Vice President of WOF Films Entertainment RJ KONNER has appeared in over 60 feature films and TV series. He was most recently featured in "Wall Street 2: Money Never Sleeps," "Extremely Loud and Incredibly Close" and "The Adjustment Bureau" to name a few. Mr. Konner brings to WOF Films Entertainment an extensive... See full bio »
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Chocolatier 2
Average Rating 50 player reviews ( 4.8 out of 5.0 )
Build an all new Chocolate Empire!
Game Description
The delicious world of chocolate is once again turned on its side, this time by deceit and deception in the new chapter of the Chocolatier saga. There is a mole controlling Baumeister Confections, and it is up to you, along with the help of the rebellious and independent granddaughter of Evangeline, to build a new empire from the ground up and take over Baumeister Confections. On this journey you will need to rise up in this industrial age of innovation and seek out secret ingredients to create rich new recipes!
Most Recent Reviews To submit a rating or review, download this game
This is one of my favorite games. It could keep me entertained for hours at a time. I enjoy the sequel better than the first version. See more See less
This game was very entertaining and worth my time and effort. See more See less
They've made improvements from the first one that I didn't even know needed to be improved, like showing how many ingredients are left, or how advanced the machines are at each factory. The new locations are fabulous. Just as good as, if not better than, the first one. See more See less
This game is amazing I didnt sleep at all in the three days I played this game. You should get this game. It was enjoyed by everyone in my family (age range 7-62) See more See less
Chocolatier is a fun active game that all you have to do is go from city to city making choclate what a tasty game.I think everyone should try this! See more See less
NO ERRORS OR FAULTS NOW NONETHELESSLY GOT SOME AND NOW HAVE NULLIFIED THE NUMBER OF THEM See more See less


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Admission: Free
Meeting Place: James A. Gaston Visitor Center
Join photographer Mike Martin for a presentation featuring a variety of images of bald eagles, songbirds, wildlife and landscapes found throughout the Ozark Mountain Region of Arkansas. Following the slideshow, Mike will discuss some of the animals shown in the slideshow along with some of his wildlife photography experiences. He will also cover some the basics of wildlife photography.
Explore Bull Shoals-White River State Park with our helpful maps and brochures! Just click on an icon to view, or right-click on your mouse to save a
copy to your computer.


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Spring Career Fair at George Mason University
George Mason University
11 a.m. to 4 p.m.
Johnson Center, Dewberry Hall
4400 University Drive
Fairfax, VA 22030
Launch your international career with the Peace Corps.
If you'd like to stay informed about Peace Corps news and events in your area, sign up to receive e-updates.
About the Peace Corps: Read more or watch a video about what it's like to be a Volunteer including what Volunteers do, where they go, and the many benefits of Peace Corps service. Or apply now to begin your life-defining experience.
Stay Connected: Sign Up for E-Updates || Facebook || Twitter || YouTube || Flickr || Tumblr || LinkedIn
For questions about this event contact Scott Kumis
If you require a reasonable accommodation when attending a Peace Corps event, please contact the recruiter identified in the "for questions about this event" section of the event listing. Please provide the details of the reasonable accommodation you are requesting.
Last updated Mar 04 2014
Reference #15665


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Oliver Holt in the Daily Mirror: "This England, Steven Gerrard said, is a better team than the one that lost 4-1 to Germany three years ago. He is right about that. The England side that was humiliated in that World Cup second round tie in Bloemfontein was a miserable, dishevelled mess. They had been demoralised and mishandled by Fabio Capello and had stumbled from one shambles to another in South Africa. So, yes, we're better than that now. The problem is, so are the Germans. In fact, the evidence suggests they have improved more than us."
Matt Barlow in the Daily Mail: "Apart from the traffic, the Germans simply adore it in London — and who can blame them? They have taken to travelling around on the Tube and have not lost in the city for nearly four decades. Neither have their reserves. They will be applying for Oyster cards next. Sadly for England there is little consolation in this defeat. They have been humbled again by their old rivals and failed to score a goal in 180 minutes at Wembley. They escaped the sort of embarrassment suffered in Bloemfontein but were beaten by a team which would be flattered to be considered Germany's second string."
Daniel Taylor in The Guardian: "Again, England suffered the ignominy of being booed inside their own stadium. They had lost for the second time in five days and when the shortcomings are this obvious, with the World Cup draw just round the corner, the only possible consolation can be that nobody surely will be foolish enough to heap unrealistic expectations on this team. Germany, like Chile, simply reminded everyone about the standard of opposition in England's qualifying programme. Joachim Löw's team did not even have to play particularly well, with their manager acknowledging afterwards he was not fully satisfied. Yet Germany could lope through the match and still expose some old failings in their opponents."
Matt Dickinson in The Times: "As if we have not tortured ourselves enough about German excellence, and our endless, despairing game of catch-up with the old enemy, this was another occasion to wonder when we will ever close the gap. Steven Gerrard had said on the eve of the game that England had improved since the defensive collapse of Fabio Capello's team at the World Cup finals in South Africa, yet the evidence of last night, and all other available signs, is that any gains made by the Three Lions have been more than matched by the Mannschaft."
Paul Hayward in the Daily Telegraph: "Germany's green shirts were the colour of English envy. Their B-team were too good for England's A-side in this "time-honoured place," as the victorious coach, Joachim Löw, called Wembley, before leaving London annoyed that their win had not been more emphatic. Unfailingly diplomatic in public, the Nationalmannschaft must punch the air in their hotel rooms to see their enemy so envious of the German system, which features triple-strength in every position and the humility to take the Tube to Wembley for training."
Sam Wallace in The Independent: "While Europe came alive with Cristiano Ronaldo's heroics in Stockholm and France's great comeback in Paris, so Wembley muttered and grumbled as a familiar plot-line unfolded involving England and those obdurate chaps they call Die Nationalmannschaft. The Germany squad had shown a laid-back, more easy-going side by taking the tube to Wembley for their training session there on Monday evening. Tonight they were back in character. Well-organised, defensively-sound and capable of scoring the crucial goal, albeit without the spark they have shown in recent years. They had lots of players missing but, well, they got the job done."
Paul Joyce in the Daily Express: For the first time in 36 years Wembley has witnessed successive English defeats though, as Roy Hodgson had argued, it is not the results which have mattered over the past five days. That he could not find too much comfort in this performance, coming so soon after the dispiriting defeat to Chile on Friday, will be far more worrying for the national coach in what was the penultimate friendly before he selects his provisional World Cup squad."
Paul Brown in the Daily Star: "England slumped to a 1-0 defeat against old rivals Germany and in the process lost successive home games at Wembley for the first time in 36 years. The defeat was not as comprehensive as Friday's 2-0 loss to Chile, but it shows just how far the Three Lions have got to progress to make any sort of impact at the World Cup in Brazil next summer."
- Sports & Recreation
- Soccer
- Fabio Capello
- Germany
- Steven Gerrard
- England


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The California ska-rock outfit known as the Aquabats just shot a pilot for a self-titled TV series with the help of comedian Bobcat Goldthwaite.
Bobcat was behind the camera for the pilot, in which the band defends its homeland of Aquabania! from an evil space monster named M. The band hopes that the show, titled "Aquabats!," will soon be picked up by a television network for the fall.
The 'Bats, who are on this summer's Vans Warped tour, co-wrote the pilot with Goldthwaite, who is expected to be named executive producer of the series when it is picked up. Bobcat is a longtime friend of the band, and directed the group's video for "Super Rad!" off of their latest album, "Fury of the Aquabats!"
Of course, the series will also feature music from the band, which re-recorded their "Theme Song!" for use in the show.


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Jewellery Cabinet - 4 Colours!£69.99 instead of £249.99 (from Pepper Tree) for a jewellery cabinet with a full-length mirror - choose from 4 colours and save 72%
Save 72%
Promotion ends on
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The Fine Print
- One per person.
- May buy multiples as gifts.
- Voucher valid until 16th Jul 2014.
- Postage costs an additional £4.99 per item.
- Please allow up to 10 working days for delivery after redeeming.
- Subject to availability.
Full Details
We all have skeletons lurking in our closets. But how about we keep our secrets - along with our favourite trinkets and treasures - stowed away in this stylish cabinet instead?
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I'd swap out the saddle and retape the bars if i bought it. Even if I liked them. Just sayin'.
OK. I am setting myself up for a weekend edition of Shun the n00b, but my curiosity has won out:
Why is this ad funny?
"Total Weight: about 8 lbs. Seriously"
Thank you.
Aye. I get it now. I had just finished taking an Anthro test right before coming here and was still lost in gametes and genetic drifts. So much for evolution.


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El Greco (Domenikos Theotokopoulos)
El Greco (painter)
Greek, 1541 - 1614
Saint Ildefonso, c. 1603/1614
oil on canvas
overall: 112 x 65.8 cm (44 1/8 x 25 7/8 in.) framed: 135.4 x 89.9 x 6.7 cm (53 5/16 x 35 3/8 x 2 5/8 in.)
Andrew W. Mellon Collection
On View
Object 6 of 8
Probably in the artist's possession at the time of his death in 1614;[1] his son, Jorge Manuel Theotocópuli, Toledo, by 1621.[2] Presented 1698 to Carlos II [1661-1700] by Don Juan Varela Colima, the King's secretary and tax collector for the city and province of Toledo.[3] Condesa de Quinto, Paris; (sale, Paris, 1862, no. 64, as Un saint Évêque écrivant, les regards tournés vers l'image de la Sainte Vierge);[4] Alphonse Oudry; (his sale, Hôtel Drouot, Paris, 16-17 April 1869, no. 139, as Prélat écrivant l'histoire de la Vierge, for 500 francs);[5] Jean-François Millet [1814-1875], Paris; his widow, Catherine Lemaîre Millet; (her estate sale, Hôtel Drouot, Paris, 24-25 April 1894, no. 261, as L'Évêque, for 2000 francs);[6] Hilaire-Germain-Edgar Degas [1834-1917], Paris; (his atelier sale, Galerie Georges Petit, Paris, 26-27 March 1918, 2nd day, no. 2, as Saint Ildefonso écrivant sous la dictée de la Vierge);[7] (M. Knoedler & Co., London and New York);[8] sold 7 February 1922 to Andrew W. Mellon, Pittsburgh and Washington, D.C.;[9] deeded December 1934 to The A.W. Mellon Educational and Charitable Trust, Pittsburgh;[10] gift 1937 to NGA.
[1] The inventory of El Greco's estate made in 1614 includes the following item: "Un S. ilefonso escribiendo" ("A Saint Ildefonso writing"); see Francisco de Borja de San Román y Fernández, El Greco en Toledo, Madrid, 1910: 193.
[2] The painting is listed in the inventory of 1621 as follows: "Un san Ylefonso bestido de cardenal escribiendo, de bara y terzia de alto y casi un bara de ancho, con quadro dorado" ("A Saint Ildefonso dressed as a Cardinal writing, a vara and a third in height and almost a vara in width, with a gilded frame"); see Francisco de Borja de San Román y Fernández, "De la vida del Greco," Archivo Español de Arte y Arqueologia 3 (1927): 70, n. 15. A vara, a traditional Spanish measurement, equals about 84 cm. Thus, the painting was said to be 112 cm tall and almost 84 cm wide.
[3] Relación del magestuoso recibimiento y entretenido cortejo de una fiesta de toros celebrada en honor de Carlos II y su esposa en Burguillos en una casa de recreación de D. Juan Varela Colima, secretario de S. M. y recaudador de los servicios de millones de Toledo y su partido...3 de junio de 1698, Madrid, 1698. The relevant passage is transcribed in Francisco J. Sánchez Cantón, Fuentes para la historia del arte español, 5 vols., Seville and Madrid, 1923-1941: 5:509-510. The presentation is described as follows: "A la Reina se ofrecieron doce albanicas de láminas primorísimas y al Rey una pintura de vara y media de alto, original del célebre Dominico Greco, que representaba a San Ildefonso con nuestra Señora, objectos predeilectísimos de la devoción de Carlos II..." ("To the Queen were presented twelve fans with exquisitely decorated blades and to the King a painting a vara and one-half in height [i.e., about 126 cm tall], an original by the celebrated Dominico Greco, which depicts San Ildefonso with Our Lady, favored objects of devotion of Carlos II..."). The NGA painting is the only work by El Greco or his workshop which corresponds to this description.
The painting is listed in the inventory of the collection at the Palacio Real, Madrid, made between 1701 and 1703, as follows: "Ytten otro lienzo de Vara y Quartta de altto y bara de Ancho poco mas de Un San Yldefonso escribiendo delantte de Una Ymagen de nuestra Señora y Un Retratto en el mismo lienzo del Griego todo tasado en treinto Doblones" ("And another painting one vara and a quarter in height [i.e. c. 105 cm] and a little more than one vara wide [i.e., c. 84 cm] of a Saint Ildefonso writing in front of an image of Our Lady and a portrait in the same painting [frame?] by Greco all valued at 30 doblones"); see Inventarios reales: Testamentario del Rey Carlos II, ed. by Gloria Fernández Bayton, 6 vols., Madrid, 1975-: 1(1701-1703):31, no. 130.
This entry seems to refer to two separate paintings which had been enframed together. Double enframing was not common, but it was sometimes utilized in the collection of paintings at the Palacio Real in Madrid. Among the 1,067 entries in the 1701-1703 inventory of the Madrid palace, there are five additional references to other small works enframed together.
It is impossible to know what portrait was enframed with Ildefonso; the portrait might be a now-lost work. Nevertheless it is tempting to posit that the Ildefonso was displayed with Greco's portrait of a Dominican or Trinitarian monk (now in the Prado). This is one of the few portraits by El Greco or his school that could be combined with the Ildefonso without significantly exceeding the measurements given in the 1701-1703 inventory. Because the subject of this portrait is a monk, the combination of this painting with the Ildefonso would accord with the practice otherwise followed in the royal collection of jointly enframing thematically related works.
[4] Manuel B. Cossío, El Greco, Madrid, 1908: 598-599, no. 299; and August L. Mayer, Domenico Theotocopuli, El Greco, Munich, 1926: 46, no. 287, maintained that Zacharie Astruc purchased the painting in Madrid and imported it to France. This is not possible if the painting was in the Condesa de Quinto's sale because Astruc made his first trip to Spain in 1864. See Sharon Fletcher, Zacharie Astruc: Critic, Artist and Japoniste, Ph.D. dissertation, Columbia University, New York, 1977 (published in the series, Outstanding Dissertations in the Fine Arts, New York, 1978): 305.
[5] The price is annotated in both the Frick Art Reference Library and the NGA copies of the sale catalogue.
[6] The price is annotated in the Frick Art Reference Library copy of the sale catalogue.
[7] In the 1990 NGA systematic catalogue (Jonathan Brown and Richard G. Mann, Spanish Paintings of the Fifteenth through Nineteenth Centuries, The Collections of the National Gallery of Art Systematic Catalogue, Washington, 1990: 44), the painting was incorrectly identified as lot number 3 in this sale, which was Saint Dominique, now owned by the Museum of Fine Arts, Boston, accession number 23.272 and identified as Saint Dominic in Prayer. Diana Kostyrko, e-mail of 18 March 2015, in NGA curatorial files, kindly pointed out the error.
[8] For an interesting account of Knoedler's purchase of this painting, see Sir Charles J. Holmes, Self & Partners (Mostly Self), London, 1936: 335-340.
[9] The date of purchase is noted in David Finley's notebook of Mellon acquisitions; original in NGA Gallery Archives, and copy in NGA curatorial files.
[10] Mellon collection records in NGA curatorial files.
Associated Names
- Carlos II, King of Spain
- Varela Colima, Juan Don
- Degas, Edgar
- Drouot, Hôtel
- El Greco
- Galerie Georges Petit
- Knoedler & Company, M.
- Mellon, Andrew W.
- Mellon Educational and Charitable Trust, The A.W.
- Millet, Catherine Lemaîre
- Millet, Jean-François
- Oudry, Alphonse
- Quinto, Condesa de
- Sale, Paris
- Theotocópuli, Jorge Manuel
|back to gallery
|continue tour


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Admission: Free
Meeting Place: Pioneer Cabin
Meet Park Interpreter BT at the to investigate the wildflowers that grow here. This program involves only a small amount of walking.
Explore Petit Jean State Park with our helpful maps and brochures! Just click on an icon to view, or right-click on your mouse to save a
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I am planning on purchasing a home from a US Home community...provided it passes inspection. Is there anything that US Home won't tell me, something that they don't have to mention or disclose, but should? This could either be regarding a potential problem with the community or the area; or this could pertain to a perk or something to write into the contract that would add to my value. What do you think?
- Forum >
- Buying & Selling Homes >
- Buying Home
I am not sure about the US Home Community, but my only advice is to get a good REALESTATE attorny. Check around they are worth the fee. I paid $350 when I recently closed. It takes a lot of stress out of signing all those documents.
My suggestion is to hire a home inspector who is NOT a building contractor (conflict of interest). Ask him what type of tests he does on the plumbing, electrical and gas in the home you are interested in purchasing. Do not hire the home inspector who just drives up takes a looksee and says everything is fine.
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Import Pre-Coded Bank Data (2:21)
3 Comments
David Bowles
November 17, 2011 at 1:49 pm
Pre-coding really is a fantastic feature – I use it all the time.
The inability to pre-code transfers to other banks of same currency is disappointing and a significant frustration at this point.
Please consider adding this functionality.
David Bowles
November 17, 2011 at 3:55 pm
Well guess what?
You CAN pre-code transfers between banks in SAME currency.
Excellent! I LOVE you Xero
xxx OOO xxx
David Bowles
November 17, 2011 at 4:06 pm
I got a little ahead of myself – we can't pre-code for transfers between banks… yet?
Xero still 'rocks'