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BlackBerry Bold dated, priced for every carrier
Posted by Peter Ha
Next Story
Orange to sell iPhone in over 10 new Markets
High res available here.
While everyone else in the free world is geeking over the iPhone 2, I'm giddy for the BlackBerry Bold. Everyone I've spoken to that currently uses a BlackBerry is psyched for this device and 90 percent scoff at the Thunder because we all know how much touchscreen phones SUCK (this goes for all of them not just the iPhone). I'm bummed I have to wait till September, though. *sad clown*
- Founded 2015
- Founders Ben South Lee, David Byttow
- Website http://bold.io
- Full profile for Bold
Verizon Communications
- Founded 1983
- Overview Verizon Communications is a broadband and telecommunications company operating 4G LTE network, 3G network, and information and entertainment services. It is a Dow 30 company that employs a diverse workforce of more than 180,000 dedicated employees around the world. It serves mass market, business, government, and wholesale customers by delivering broadband and other wireline and wireless communication …
- Location New York, NY
- Categories Mobile, Information Technology, Communications Infrastructure
- Website http://www.verizon.com/
- Full profile for Verizon Communications
Sprint Nextel
- Founded 1999
- Overview Sprint Nextel offers a comprehensive range of wireless and wireline communications services bringing the freedom of mobility to consumers, businesses and government users. Sprint Nextel is widely recognized for developing, engineering and deploying innovative technologies, including two wireless networks serving almost 49 million customers at the end of the second quarter of 2009; industry-leading …
- Location Overland Park, Kansas
- Categories Wireless, Mobile
- Website http://sprint.com
- Full profile for Sprint Nextel
- Founded 1984
- Overview BlackBerry provides wireless devices and solutions for the worldwide mobile communications market. It is widely known for the development of the Blackberry smartphone. It offers the BlackBerry wireless communications platform solution, which includes the commpression and security infrastructure services enabling BlackBerry hand-held wireless devices to send and receive wireless messages and data. …
- Location Waterloo, ON
- Categories Telecommunications, Mobile, Wireless, Software, Hardware
- Founders Douglas Fregin
- Website http://us.blackberry.com
- Full profile for BlackBerry


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Mon Tulfo shows dance moves in Gandang Gabi Vice
Posted at 05/28/2012 12:04 PM
Controversial veteran columnist Mon Tulfo shared his funny side on "Gandang Gabi Vice!" on Sunday night. Mon, eldest of the Tulfo brothers, gamely answered funny questions from Ganda. He also shared his dancing prowess as he danced the Wondergirls' hit "Nobody." Gandang Gabi Vice, May 27, 2012

subset: commoncrawl


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Heroes and Castles 2 Has its Own Standalone Free Version
Heroes and Castles 2 is a third-person castle defense game from the same team behind Block Fortress and Bug Heroes. It's cool, it's fun, and now it has its very own free version.
Heroes and Castles 2 is a third-person castle defense game from the same team behind Block Fortress and Bug Heroes. It's cool, it's fun, and now it has its very own free version.
Block Fortress is a survival-style game that's as fun as it is blocky. It's also just gotten a rather sizeable update that adds a lot more cool stuff.
Foursaken Media has released a new trailer for their upcoming game, Heroes & Castles 2.
It's an action, strategy, castle defense game somewhat similar in play style to the classic Dynasty Warriors, and Heroes & Castles 2 will have you wading into the thick of it as you fight waves of enemies. The graphics look like they have gotten a signifigant upgrade since the first game, and we can't wait to see what else has changed.
While there is no official release date as of yet, you can sate your Heroes & Castles 2 lust momentarily with the trailer.
Phantom Rift, the mystical RPG from Foursaken Media, has gone on sale. As such, it takes $2 off its regular price of $2.99, bringing it down to $0.99.
We had an opportunity to check out Phantom Rift last year, and found it quite enjoyable. We also have all the tips and tricks one might need to master the game.
As noted, Phantom Rift is currently available for $0.99 on the App Store.
Puzzle to the Center of the Earth is a surprisingly deep and challenging puzzle platformer. Here are a few tips for players looking to stay alive while down in the depths.
Phantom Rift from Foursaken Media is a deep adventure/role-playing game that centers around intense battles with enemy monsters. It plays a good deal like Capcom's Mega Man Battle Network, which thrived on the Game Boy Advance, and veterans of that series should be able to sink right into Foursaken's title.
But that doesn't mean surviving the Rift is easy. Here are some tips that will help keep you alive in this strange, dark world.
Phantom Rift by Foursaken Media, is an adventure/RPG where players control a powerful wizard who has become lost in the Phantom Rift: a dark place full of man-eating monsters. Wizards will be tasked with side quests as they explore the world and meet NPCs.
A player's wizard is fully customizable with a full array of equipment. The five levels of rarity with passive abilities and different stats mean plenty of different combinations for collectors.
The innovation of Phantom Rift is its battle system. Similar to a card-based battle, players have a spell pouch that can hold up to 30 of the 120 unique spells that can be found in the game. Players can equip their wizard with different spells to form different strategies, focusing on things like elemental magic or summoning.
The game also has multiplayer integration. Wizards can fight in PvP battles and win spells from their enemies' pouch as trophies.
Foursaken Media is shooting for a September release for Phantom Rift.
Everyone's favorite (or not, because of free will and all that) bug-themed action defense game has received a sizable new update from the "Man Gods."
In addition to the various tweaks and balancing changes (listed below), an entirely new game mode with over 20 missions has been introduced. Turret Defense places a much heavier emphasis on building turrets and making use of pathways in an effort to stop waves of enemies from noshing on your food supplies. It also includes a new hero (the Garden Beetle), new power-ups, and makes use of the newly-introduced Laser turret.
Assuming you haven't already (why the heck not??), you can grab Bug Heroes 2 off the App Store for $1.99.
• Added a new turret: Laser!
• Many higher star missions made easier
• Balanced turret upgrade prices
• Balanced stun scroll effect on high rate of fire heroes
• Fly Bandito and Army Ant Cavalry abilities have unit caps
• Sniper Turret bullets move much faster, but they no longer target heroes in versus mode
• Revamped mission system to allow many more mission choices and options at once
• Fixed an issue with versus local multiplayer
• Miscellaneous bug fixes
Bug Heroes 2 has been approved and is now set to launch on February 20. The sequel to the game that blended tactical action and defense elements is set to offer players 25 unique heroes that include a Waterbug pirate, Bumblebee boxer, and a grenade-launching worm. Players will also be searching for food and material, fortifying their base, building turrets, leveling up their heroes, and more, all while playing alone, in 2 players co-op, or 2v2 competitive multiplayer battles.
Block Fortress War is coming soon, bringing a redesigned spin-off of the original Block Fortress. In a forum post on Touch Arcade, Foursaken Media said that it blends MOBA, RTS, and block-building gameplay together in both single and multiplayer modes. It features four different races that each have their own traits and abilities, and each race has three unique heroes to choose from.
Once players get themselves in combat, they'll send their squads out to build key resources on the map and fortify them with blocks and turrets. Whoever gains control of the map is more likely to gather all the resources to use in destroying the enemy's base.
Block Fortress War is set for a tentative release in December of this year.


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Observing the International Longshore and Warehouse Union drama at the Port of Vancouver, I have the following remedies and suggestions to offer those ILWU members locked out from United Grain:
The jobs from which you've been locked out don't belong to you. They belong to the owner of the facility no matter what your minders tell you.
Clearly these jobs can be performed successfully by others not in your union.
If you signed the contract offered by the employer, you would be employed at wages that far outstrip your educational level.
You were locked out for good reason. See point No. 1.
John Newton


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[Pounds Sterling]2,000 Bill for Single Gaelic Holyrood Tour
Byline: Mark Howarth
THE Scottish parliament splashed out more than [pounds sterling]2,000 on a Gaelic translation of an audio guide for visitors - which has been used by only one person.
Non-English speakers who take the official tour of Holyrood can listen to hi-tech headsets giving information about the [pounds sterling]414million building in their native tongue.
But while the French, Spanish and German versions have all proved popular since their launch last year, the Gaelic gadgetry has been used only once.
Critics last night claimed that Scotland's public sector had become 'obsessed' with the minority language.
TaxPayers' Alliance spokesman Fiona McEvoy said: 'There were probably good intent ions behind this but the desire to be politically correct seems to have overtaken common sense.
'In these straitened times all spending has to be justifiable. This is the perfect example of just how important it is to establish demand before splashing taxpayers' money around.' The lack of interest in the Gaelic language tour was revealed in the Scottish Parliament Corporate Body's Annual Equalities Report which covered the period up to last April.
It states: 'Tours of the parliament using hand-held audiovisual guides were introduced in this reporting year and are available in 14 different languages: Arabic, Bengali, Cantonese, French, German, Italian, Mandarin, Polish, Punjabi, Russian, Spanish, Urdu, Gaelic and BSL [British Sign Language]. …


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Reading the coverage…
Houston Texans
After clinching their first playoff spot, the Texans celebrated and talked of feeling like a team of destiny, says John McClain of the Houston Chronicle. Andre Johnson got a game ball without even playing in a nice gesture by Gary Kubiak.
"When T.J. Yates and Kevin Walter finally connected for the game-winning score with two seconds remaining to silence the small crowd at Paul Brown Stadium, this never-say-die team from a so-often-dead organization had delivered a victory for the ages," writes Jerome Solomon of the Chronicle.
Johnathan Joseph's return to Cincinnati was largely uneventful and he allowed A.J. Green to make some plays, says Jeffrey Martin of the Chronicle.
The final drive brought out the best in Yates and the Texans, says Martin.
Defensive adjustments by Wade Phillips and his staff played a big part in things, says McClain.
Dale Robertson of the Chronicle ranks it the second-biggest NFL win in Houston history.
Owner Bob McNair thinks Kubiak should be a prime coach of the year candidate, writes McClain.
Yates' parent has bad seats, says Shutdown Corner.
Indianapolis Colts
The Colts got nowhere against the Ravens vaunted defense, says Phil Richards of the Indianapolis Star.
Two sacks mean Dwight Freeney is just the 26th player in NFL history to top 100 in his career, say Mike Chappell and Richards of the Star.
Phillip B. Wilson of the Star saw the same old, same old.
The terrible Colts are one of the worst teams in NFL history so they didn't tell the Ravens much about themselves, says Mike Preston of the Baltimore Sun.
If the Colts have talent beyond Peyton Manning, why are they so terrible? Nate Dunlevy of 18to88 examines the question. I particularly like point three about the coaches being arrogant and uncreative.
It's getting awkward in Indy, says Jason Gay of the Wall Street Journal.
Jacksonville Jaguars
The Jaguars absolutely rolled Tampa Bay, says Tania Ganguli of the Times-Union.
On a monster day, Maurice Jones-Drew broke his mentors Fred Taylor's franchise record for touchdowns, says Vito Stellino of the T-U.
This was no monumental breakthrough, but the Jaguars will take the glimpse of sunshine, says Gene Frenette of the T-U.
Blaine Gabbert delivered a better effort, says Ganguli.
An unlikely pair -- tight end Colin Cloherty and defensive end Nate Collins -- found the end zone for the Jaguars, says Vito Stellino.
Tennessee Titans
The Titans hope this loss isn't one that ultimately kills their playoff chances, says Jim Wyatt of The Tennessean.
The Titans now have no margin for error in their playoff bid, says David Climer of The Tennessean.
Injuries to key players piled up, says John Glennon of The Tennessean.
A third-down discrepancy meant the Saints were able to control the ball, says Glennon.
Jake Locker showed the Titans a big glimpse of the future, says Wyatt.
Don't grade the Saints on aesthetics, this is the sort of gritty win they needed, says Don Banks of SI.com.


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Tallahassee Community College boosts affordability, access in math courses using open educational resources
In 2015 there were roughly 20 million students in the United States. Why is this significant? According to this release from Lumen Learning, which is similar to others I've seen, the use of open educational resources - specifically, open textbooks - saved 4,825 students some $535,000 in that same year. That's more than $1,000 per student, which means that this program alone, if applied nationally in the U.S. would save students $20 billion - with a B. Now this number is probably high - the average student spends only $900 on textbooks, and the entire market size is only $14 billion, so we're not going to hit $20 billion. But no matter what, the numbers are staggering. Which begs the question: why is this not happening?
Today: 239 Total: 239 Press Release, Lumen Learning, 2016/05/27 [Direct Link]
"Transforming" Public Schools: Enough already with an Overhyped Word!
At a certain point of overuse a word loses its meaning. "Transform" is one such word, according to Larry Cuban. "When it comes to school reform, as the quotes above indicate, the word 'transform' hits the jackpot of overhyped words in reformers' vocabulary.... Yes, I have gotten allergic to the word 'transform' when it is applied to schooling. That allergy has prompted me to ask any policymaker, researcher, practitioner, high-tech entrepreneur, venture capitalist, or parent using the word, certain questions about what he or she means." What follows is a lost of questions that should be asked of people promoting transformation. What does it mean? What problems are being solved? What exactly is transformed? What does it become? How fast? Why is it better? But, of course, these questions could be asked against any of our buzzwords today - analytics, reform, open, online, whatever. And they should be asked. Slogans aren't plans.
Today: 209 Total: 209 Larry Cuban, Larry Cuban on School Reform, Classroom Practice, 2016/05/27 [Direct Link]
MediaSmarts launches comprehensive digital literacy framework for secondary schools
MediaSmarts (which once upon a time had a much better name, the Media Awareness Network) has released the final installment of Use, Understand & Create: A Digital Literacy Framework for Canadian Schools. The framework "includes over 50 lessons and interactive games, organized by grade level from kindergarten to grade 12, that are aligned with seven aspects of digital literacy: finding and verifying; ethics and empathy; privacy and security; digital health; consumer awareness; community engagement; and making and remixing." View the framework here. For the theoretical background, see this "mapping of the features and focal points of digital literacy and digital citizenship from across the country": 75 page PDF.
Today: 257 Total: 257 Press Release, MediaSmarts, 2016/05/27 [Direct Link]
Key Tensions in the Field of Learning Analytics
This is an interesting and useful post. Bodong Chen first distinguishes between learning analytics and academic analytics (the former being directly concerned with teaching and learning) and educational data mining (the latter being more focused on the exploration of data from academic settings). He then outlines some areas of interest: first, the emphasis on big data in learning analytics, and second the need for it to consider the more nuanced aspects of learning itself. This leads to a discssion of the 'tensions': first, divisions based on different accounts of learning; second, the tension between learning and algorithms; third, agency and control; and fourth, the ethics of learning analytics. It's also worth viewing his Learning Analytics course.
Today: 202 Total: 746 Bodong Chen, 2016/05/26 [Direct Link]
Communities Need Tools to Protect Themselves From Scale
Best takedown of the day: "The state of knowledge among people who have actually run large online communities is so far advanced beyond the research community that most research in this area is more amusing than helpful." The line comes from Michael Caulfield and he cites Clay Shirky on a pre-2011 truism about online community: "You have to find some way to protect your own users from scale... you can't try to make the system large by taking individual conversations and blowing them up like a balloon." This of course is what we were also trying to do when we shifted our MOOC users away from the centralized Moodle platform and into their own blogs and communities. And as Caulfield says, "This is discovered repeatedly throughout history, and you could write a taxonomy of different techniques we use to protect users from scale." Image: Waltman and van Eck, community detection (worth a read in its own right).
Today: 148 Total: 872 Michael Caulfield, Hapgood, 2016/05/25 [Direct Link]
The Limits of Competition
I have a story I often tell. Suppose, I say, two people want to travel from Edmonton to Calgary. What's the best way to do this? Should they each get a separate car and race? Should they bid against each other for the one remaining car, with only the winner traveling? No, competition won't get these drivers to Calgary faster nor more efficiently. The rational thing to do is to share a ride. John Warner writes, "Competition works really well when the goal is to determine who is a winner and who is a loser and the winners benefit, receiving their tributes and rewards. When the rewards are outsized, or the punishment severe, truly terrible behaviors can result." He's right.
Today: 86 Total: 590 John Warner, Inside Higher Ed, 2016/05/25 [Direct Link]
Sponsored this month by: Rory McGreal


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Posted October 22, 2013 and updated on May 27, 2016
The Internship
The most recent home video release of this movie is October 22, 2013. Here are some details…
Home Video Notes: The Internship
Release Date: 22 October 2013
The Internship releases to home video (Blu-ray/DVD Combo Pack) with the following extras:
- Any Given Monday
- Theatrical and Unrated Audio Commentary with Shawn Levy
- Sneak Peeks
- Deleted Scenes
Related home video titles:
Age and experience are also underappreciated when a young up-start is made manager over older employees in the movie In Good Company. A job layoff causes a whole new life direction for a dutiful worker named Larry Crowne. And Owen Wilson plays another character that begins to reinvents himself when he has an unexpected encounter with some of his idols in Midnight In Paris.


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beverage container Companies in Mozambique
Beverage Industry Environmental Roundtable (BIER)
based in MINNESOTA (USA)
BIER is a partnership of leading global beverage companies working together to advance the standing of the beverage industry in the realm of environmental stewardship. The partnership was formed in 2006 and is facilitated through member-hosted Roundtable meetings and working groups on key issues.
Shred-Tech Corp.
based in Cambridge, ONTARIO (CANADA)
Shred-Tech is globally recognized for designing and manufacturing first-class reduction systems and shredding machinery to cost-effectively meet your waste reduction and recycling needs.Shred-Tech® is a world leader in information destruction and reduction solutions. Shred-Tech designs and manufactures reduction systems and shredding machinery to cost-effectively solve ...
Wissenschaftlich-Technische Werkstätten (WTW) GmbH - a xylem brand
based in Weilheim, GERMANY
WTW offers robust analysis products for the measurement of pH, dissolved oxygen, conductivity, total dissolved solids and specific ions in lab, field and on-line applications serving the environmental, water and wastewater, food and beverage, educational, pharmaceutical, clinical, research and chemical/petrochemical industries. WTW has provided outstanding leadership in ...
Verderflex Peristaltic Pumps - part of the Verder Group
based in Castleford, UNITED KINGDOM
Verderflex Peristaltic tube and hose pumps from Verder have gained worldwide prominence particularly in dosing applications involving abrasive, highly corrosive, viscous, high density and shear sensitive products within industries such as water and waste water, food & beverage, chemical, biofuel, print & packaging and ceramics. Verderflex peristaltic pumps have a ...
Q-Lab Corporation
based in Westlake, OHIO (USA)
Q-Lab Corporation is a global provider of material durability testing products since 1956. We design and manufacture standard test substrates as well as weathering, light stability, and corrosion testers. In addition, contract test services which include accelerated laboratory testing and outdoor exposure testing for weathering, lightfastness and corrosion are available ...
Glass Packaging Institute (GPI)
based in Alexandria, VIRGINIA (USA)
Glass Packaging Institute (GPI) is the trade association representing the North American glass container industry. Through GPI, glass container manufacturers speak with one voice to advocate industry standards, promote sound environmental policies and educate packaging professionals. GPI member companies manufacture glass containers for food, beverage, cosmetic and many ...
Tomra Systems ASA
based in Asker, NORWAY
TOMRA Reverse Vending is focused on providing efficient and convenient systems for collecting and processing used beverage packaging. TOMRA is a leading player, exceeding 67,000 installations in more than 30 markets worldwide.
CO2 Meter, Inc.
based in Ormond Beach, FLORIDA (USA)
CO2Meter.com manufacturers and distributes carbon dioxide meters and other gas meters, sensors and indoor air quality monitors used in the HVAC, scientific, horticultural, food & beverage and many other industries.
RWL Water LLC
based in Minneapolis, MINNESOTA (USA)
RWL Water provides desalination, water, wastewater, waste-to-energy, recovery & reuse, and food & beverage processing solutions to municipalities and industries. The Company's internationally experienced and highly responsive team is dedicated to delivering leading edge solutions globally.
Continental Disc Corporation - Groth Corporation
based in Liberty, MISSOURI (USA)
Continental Disc Corporation is a leading manufacturer of rupture disc devices for a variety of process industries, including chemical, petrochemical, petroleum refining, pharmaceutical, beverage, food and dairy, aerospace, gases, electronics, and other markets worldwide.


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S2K Commerce - Products DropdownActions
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Our Curriculum
Recognizes the Bible, God's truth, to be the foundation of wisdom and education.
Utilizes hands-on, unit studies with daily lesson plans that are easy-to-teach.
Enables families and multi-age groups to learn together. Many of our programs may be taught to a range of ages simultaneously.
Combines the best of Charlotte Mason's ideas and classical education with a Biblical worldview, an international focus, and our own observations of how children learn.
Provides easy-to-teach, integrated curriculum that is enjoyable, academically strong, and focused on character development.
Is committed to the Lord of All, who tenderly searches for people from every tribe and language. A portion of our profits helps support missions work overseas, especially Bible translation projects. Our heart's desire is that someday soon all people would be able to read of God's love in their own language.
My Father's World Statement of Faith
We believe that this world and all of its inhabitants were created by our loving God for eternal fellowship with Him. Man, by his sin, has become separated from God, and only through personally accepting the gift of reconciliation purchased by Jesus at the cross can he regain his fellowship with God. We believe that Jesus is the way, the truth, and the light, and only through Him may people find peace with God.
We believe that the Bible is the truly inspired word of God, that it is fully accurate, and that it contains the wisdom of God that we need for our lives. As we read the Bible, the Holy Spirit instructs our hearts and minds to understand God's eternal truth and shows us how to apply that truth to our lives today.
We rejoice that God has adopted us as his children. We know that when we die we will be with Him in heaven forever. We look forward to worshipping Him with the multitudes from every tribe and nation. We believe that He has given us the task here on earth to enable others to hear (in their native language) the Good News that their Creator longs for them with an immeasurable love, and that He has made a way for them to be reconciled to Himself.


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Second American Congress on Obstetrics and Gynecology.—The Second American Congress on Obstetrics and Gynecology will be held in St. Louis, April 6 to 10, 1942. All of the meetings and the commercial and educational and scientific exhibits will be held in the public auditorium.The following committees, with their chairmen, have been appointed: executive, Dr. Fred L. Adair, Chicago; program, Dr. E. D. Plass, Iowa City; motion picture, Dr. Robert D. Mussey, Rochester, Minn.; educational and scientific exhibits, Dr. H. Close Hesseltine, Chicago; commercial exhibits, Dr. Philip F. Williams, Philadelphia; lay publicity, Dr. Joseph L. Baer, Chicago; professional publicity, Dr. George W. Kosmak, New York; publications, Dr. Goodrich C. Schauffler, Portland, Ore.; evening meetings, Dr. Robert L. De Normandie, Boston; membership, Dr. Buford G. Hamilton, Kansas City, Mo., and budget and finance, Dr. William C. Danforth, Evanston, Ill.The general plan for the program will be much
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Pets Ready for Adoption
All dogs and cats available for adoption are healthy to the best of our knowledge and have been treated for all injuries and/or conditions with which they came to the Humane Society. They are all spayed/neutered, current on shots (including rabies, if old enough), heartworm-tested (and if heartworm-positive, they are treated by HSMSC), on heartworm prevention treatment, and have been micro-chipped. Once adopted, any subsequent veterinary charges will be the responsibility of the owner.


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Pétain's exiles and De Gaulle's deportees
Nowhere was the repatriation more central to the post-war political challenges than in France. Unlike Belgium and the Netherlands, where pre-war governments prepared for their return to power after the liberation, the French National Liberation Committee had to struggle for legitimacy with Vichy, the constitutionally legitimate heir of the prewar Third Republic.
The Vichy regime (and Pétain personally) had turned the exile of 1,500,000 French soldiers into a cornerstone of its ideology of atonement and resurrection, and, more unfortunately still, into a touchstone of the effectiveness of its policy of collaboration.1 The fate of the French army after its collapse in May and June 1940 had been a major argument for Marshal Pétain, commander-in-chief, to assume the political responsibility of the armistice and the subsequent 'French State', much in the way that the Belgian King Leopold had legitimised his surrender and his refusal to leave the country after the defeat. Philippe Pétain, the soldierhero of the Great War, acted as the father of his troops, the saviour and protector from further useless bloodshed. One of the immediate consequences of national collaboration with the victors had been that Vichy took responsibility for the protection of its PoWs under the terms of the Geneva convention, instead of reverting to diplomatic representation by a neutral nation, as all other defeated countries had done. As the next chapter will discuss, the regime engaged in lengthy and wearisome transactions to liberate PoWs by promoting the voluntary departure of three civil workers in return for each liberated PoW, the so-called relève or relief. It suggested the 'transformation' of PoWs into civil workers, thereby voluntarily abandoning the protection of the Geneva convention. Later, it even defended and enforced the deportation of French workers to Germany. The results of this policy were catastrophic for Vichy's popularity, and for the French PoWs. Whereas Dutch and Flemish PoWs were mostly liberated during the first year of war by____________________


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I've heard a few people say that clipless pedals are the way to go with recumbent. Which ones would you recommend? I've used a pair of cheap ones on my DF mountain bike and, as much as I like them, getting clipped in is sometimes a struggle. I would imagine that it could be even more difficult on a recumbent with certain brands. Thoughts?
- Jeremy


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The Americans with Disabilities Act (ADA) has been in place for more than 20 years, with major revisions enacted in 2009. Since its release in September of 2010, the language outlined in the 2010 Standards for Accessible Design (SAD) has not changed. However, as of March 2011, the ADA gained teeth -- compliance is now required and enforceable on the federal level.
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South Africa opener Alviro Petersen does not believe the Proteas need to win in Australia to justify their position at the top of the world Test rankings.
The tourists won on their last visit Down Under - 2-1 in 2008/09 - and went on to become the only team to be ranked number one in all three formats of the game. Despite slipping to second and fifth in the one-day international and Twenty20 rankings respectively, South Africa remain the top Test team while Australia sit third.
Asked whether South Africa had to reaffirm their Test credentials with another series win against a reinvigorated and new-look Australia side, Petersen said: "We did it last time...I don't know how many times we have to do it."
He added: "Last time we beat them here in Australia we weren't the number one Test team in the world and we were chasing (the ranking), this time we are holding on to it.
"The basics remain the same though, we want to win Tests and it's important that we do that in the next couple of games. We've played good cricket under pressure and we've played good cricket home and away...that's why we are the number one Test team in the world and that will count for a lot.
"We have come together as a unit - it's like a collective force - and from that point of view we are very comfortable with ourselves as a team. We will try and do exactly the same as what we've done in the last couple of years to bring us to that number one status."
Petersen also welcomed any further sledging the Australian bowlers intended to throw their way.
Victoria fast bowler Peter Siddle told Channel Nine News earlier this week he felt the Proteas' top-order were "distracted" by the verbal onslaught he and fellow paceman James Pattinson engaged in.
And he predicted more of the same when the second Test got under way at the Adelaide Oval on Thursday.
Petersen replied: "If that's their strategy then so be it, but I don't know about being distracted because I didn't see any of our batsmen distracted."
- Sports & Recreation
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HANOVER: The township Little League 9/10 year old softball team recently finished second in the state championship tournament held at Middletown's Bodman Park from Thursday to Monday. Hanover qualified for the states tournament by defeating Morristown National Little League in the District 1 final. Hanover then beat Lakeland Little League 11-0 and Pequannock Little League by scores of 5-1 and 14-0 to capture the Section 1 championship and advance to the New Jersey Little League State Tournament.
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Since the early days when the Peterson Bay Field Station opened in 1983, visitors to the Center for Alaskan Coastal Studies environmental education center started their trip off with a little exercise. After arriving by boat from Homer, visitors got off at a floating dock and then onto a raft. Hauli...Wed, 07/16/2014 - 4:35pm
In three separate incidents last week, vehicle crashes killed a Wasilla woman and injured two Homer women. Police and troopers said all three incidents involved alcohol. The most serious incident happened about 6:20 p.m. July 4 when a Wasilla woman flipped her all-terrain vehicle while crossing Star...Wed, 07/09/2014 - 3:58pm
Throw a monkeyfist-knotted rope in the Homer Harbor, and odds are you'll hit a Tolman skiff. From its versions as open skiffs to stout cabin cruisers, the classic Kachemak Bay boats can be seen not only in Homer, but up and down the Alaska and Pacific coasts and even as far away as Norway an...Wed, 07/09/2014 - 3:52pm
If it's late summer, that means it's Concert on the Lawn time. But wait — it's not late summer and only the second weekend in July. A long-time summer tradition, except when it was a fall tradition, KBBI Public Radio's annual Concert on the Lawn is held two weeks earlier this year. The two...Wed, 07/09/2014 - 2:31pm
Forty-five years ago humans first walked on the moon. By 1979, it's hard to believe that with advances in science and technology, including satellite broadcasts, Homer didn't have a radio station. A live broadcast on Aug. 4, 1979, changed all that when Beverly Munro, one of the founding members ...Wed, 07/09/2014 - 1:14pm
With three Republican Party candidates fighting to oppose him in the general election, Sen. Mark Begich, D-Alaska, visited Homer and Seldovia last weekend as part of a grassroots campaign laying the groundwork for the November election. The Alaska Democratic Party soon plans to open a Homer of...Wed, 07/02/2014 - 4:01pm
A Nikolaevsk man died from injuries in a single-car crash on the North Fork Road last Friday. Ivola Usoltseff, 59, was pronounced dead at South Peninsula Hospital after being treated and transported there by Anchor Point Emergency Services medics. According to an Alaska State Trooper press rel...Wed, 07/02/2014 - 3:44pm
An East End Road man arrested for second-degree terroristic threatening has had the felony charge dismissed and was released on June 20. Homer Judge Margaret Murphy ordered the charge against Joe Kuzmin, 38, dismissed because there was not a preliminary hearing held for him within 10 days of h...Wed, 07/02/2014 - 3:42pm
The State Medical Examiner positively identified Paul Baylink, 46, as the person killed in a Rainbow Court house fire on June 13, Homer Police announced in a press release Tuesday afternoon. An autopsy was done on June 17, but police have not received the report and do not know the cause of death, s...Wed, 07/02/2014 - 3:41pm
With First Friday in July falling on Independence Day, some Homer galleries have chosen to hold art openings on Saturday so as not to conflict with the Pioneer Avenue parade, making it a First Weekend full of art. Art lovers can split their weekend. Bunnell Street Arts Center in Old Town and the Hom...Wed, 07/02/2014 - 3:12pm
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hello Casey, I got to agree with revwizard on the mid vent it is a great all around kite. If you can make it to the wsikf august 19-25 there is a good chance you would be able to fly a bunch of different rev types, or at least the ones you had questions about. hope to see you there.
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Capacity and
German and Japanese compliance with the American agenda has been far from complete, though both countries have participated in international control agreements from the Shanghai Commission in 1909 to the UN Convention of 1988. The United States has taken it as a basic premise that this pattern of partial compliance is directly related to the domestic capacity of each country's policy makers. Clearly, however, this explanation, applied for the past ninety or so years to bilateral and multilateral relations, has failed to read German and Japanese responses accurately. This final chapter briefly summarizes the findings of the preceding analysis before turning to their implications for the future of U.S. drug control.
Prominent scholarship suggests that weak state capacity, stemming from preconditions such as limited territorial integrity and financial resources or from dynamics generated by state and societal structure, can lead to involuntary or voluntary defection from agreements. The United States has taken this hypothesis as its basic premise in attempting to account for noncompliance with the


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Are you Gilles Pomier Layrargues?Claim your profile
Publications (20)105.86 Total impact
Article: Differential effects of ammonia on the benzodiazepine modulatory site on the GABAA receptor of human brain. Neurochem Int[Show abstract] [Hide abstract] ABSTRACT: Ammonia is a key factor in the pathogenesis of encephalopathies associated with liver failure. A direct effect of ammonia on GABAergic neurotransmission was proposed as a mechanism that may explain its neurotoxic effect on the basis of electrophysiological and biochemical studies performed in animal models of liver failure. In the present study, we investigated using a radiometric assay the effect of ammonia on the binding of GABA-A receptor ligands to membranes from normal human brains. Ammonium tartrate significantly decreased the maximal binding of [3H]flunitrazepam to well-washed frontal cortical membranes (366+/-63 fmol/mg protein in absence of ammonia versus 294.1+/-51 fmol/mg protein in presence of 2 mM ammonia; p<0.05). The efficacy of the effects of ammonia was within the millimolar range (IC50=4.8 mM). This effect was not seen in cerebellum or hippocampus. Ammonia exposure decreased the maximal binding of [3H]flumazenil (284.9+/-24.2 fmol/mg protein in absence of ammonia versus 146.4+/-15.6 fmol/mg protein in presence of 2 mM ammonia; p<0.01). This effect was seen with a greater potency (Imax=32.4%) and a lower IC50 (0.1 mM). Inhibition of [3H]flumazenil binding was significant in all brain regions. The apparent ammonia-induced decrease of [3H]flunitrazepam and [3H]flumazenil binding was due to a decrease in the binding affinities of these ligands for the benzodiazepine site. In contrast, ammonium tartrate exposure did not cause significant changes to the binding of [3H]muscimol in any brain region. These findings demonstrate that ammonia interacts negatively with components of the benzodiazepine-associated site at the GABA-A receptor complex in human brain in contrast to previous reports in the rat, and thus, does not support the notion that ammonia directly activates the GABA-A receptor complex resulting in increased GABAergic neurotransmission in human hepatic encephalopathy. These findings also suggest that positron emission tomography studies in cirrhotic patients using [11C]flumazenil may be underestimating GABA-A receptor sites depending upon the degree of hyperammonemia of the patient.
Article: Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy
- [Show abstract] [Hide abstract] ABSTRACT: Hepatic encephalopathy is characterized by a variety of neurological symptoms. The occurrence of movement disorders is exceptional and is usually part of a clinical syndrome called acquired hepatocerebral degeneration, which is a subtype of chronic recurrent hepatic encephalopathy. The clinical picture is usually progressive and pathologic findings include regional astroglial and neuronal abnormalities found predominantly in cortex and basal ganglia. As for hepatic encephalopathy in general, the pathophysiology of this disorder is unknown but hyperammonemia and/or brain manganese overload may play a role. Medical treatment is often disappointing but in selected cases liver transplantation may be curative.
- [Show abstract] [Hide abstract] ABSTRACT: Amongst the potential neurotoxins implicated in the pathogenesis of hepatic encephalopathy, manganese emerges as a new candidate. In patients with chronic liver diseases, manganese accumulates in blood and brain leading to pallidal signal hyperintensity on T1-weighted Magnetic Resonance (MR) Imaging. Direct measurements in globus pallidus obtained at autopsy from cirrhotic patients who died in hepatic coma reveal 2 to 7-fold increases of manganese concentration. The intensity of pallidal MR images correlates with blood manganese and with the presence of extrapyramidal symptoms occurring in a majority of cirrhotic patients. Liver transplantation results in normalization of pallidal MR signals and disappearance of extrapyramidal symptoms whereas transjugular intrahepatic portosystemic shunting induces an increase in pallidal hyperintensity with a concomitant deterioration of neurological dysfunction. These findings suggest that the toxic effects of manganese contribute to extrapyramidal symptoms in patients with chronic liver disease. The mechanisms of manganese neurotoxicity are still speculative, but there is evidence to suggest that manganese deposition in the pallidum may lead to dopaminergic dysfunction. Future studies should be aimed at evaluating the effects of manganese chelation and/or of treatment of the dopaminergic deficit on neurological symptomatology in these patients.
- [Show abstract] [Hide abstract] ABSTRACT: Patients with chronic liver disease manifest a high incidence (> 75%) of pallidal signal hyperintensity on T1-weighted Magnetic Resonance Imaging (MRI), the intensity of which correlates with blood manganese levels and the presence of extrapyramidal symptoms. A major cause of pallidal hyperintensity on T1-weighted MRI is manganese deposition; chronic manganese intoxication in the absence of liver disease results in pallidal MR signal hyperintensity, in extrapyramidal symptoms and in selective effects on the dopaminergic neurotransmitter system in basal ganglia. Direct measurements in globus pallidus obtained at autopsy from patients with chronic liver disease who died in hepatic coma reveal 2 to 7-fold increases of pallidal manganese and a concomitant loss of dopamine D2 binding sites. Liver transplantation results in normalization of pallidal MR signals and of blood manganese levels. These findings suggest that (1) pallidal MR signal hyperintensity in patients with chronic liver disease is the result of manganese deposition and (2) alterations of dopaminergic function due to the toxic effects of manganese may contribute to the extrapyramidal symptoms in these patients.
- [Show abstract] [Hide abstract] ABSTRACT: Concentrations of zinc, copper and manganese were measured by atomic absorption spectrometry in samples of globus pallidus obtained at autopsy from 9 patients with chronic liver disease and an equal number of age-matched controls. Manganese concentrations were significantly increased several fold (p < 0.01) in globus pallidus of liver disease patients accompanied by smaller but significant 2-fold increases of copper. Zinc concentrations, on the other hand, were within normal limits. Increased pallidal manganese offers a cogent explanation for the observed T1-weighted MRI signal hyperintensity in pallidum of cirrhotic patients. Increased copper content in brain suggests the existence of common pathophysiologic mechanisms in inherited (Wilson Disease) and acquired hepatocerebral disorders.
Article: Increased manganese (Mn 2+) in blood and in pallidum of cirrhotic patients with hepatic encephalopathy: Factor responsible for magnetic resonance (MR) Signal hyperintensity?
Article: Region‐Selective Decreases in Densities of [3H]Tryptamine Binding Sites in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy[Show abstract] [Hide abstract] ABSTRACT: The distribution of [3H]tryptamine binding sites, in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy (HE) and an equal number of age-matched control subjects free from hepatic, neurological, or psychiatric disorder, was investigated. Scatchard analysis demonstrated a heterogeneous distribution for this binding site, with the highest density being observed in hippocampus > frontal cortex = caudate nucleus > temporal cortex = cerebellum. When comparing [3H]tryptamine binding site densities in control brain tissue with that in brain tissue from patients with HE, significant decreases in densities were observed in the frontal cortex (by 56%, p < 0.001), hippocampus (by 43%, p < 0.001), and caudate nucleus (by 41%, p < 0.01) of the HE group. Binding site affinities were within normal limits. The findings of decreased densities of [3H]tryptamine binding sites taken in conjunction with previous reports of increased CSF and brain tryptamine concentrations in HE suggest a pathogenic role for this neuroactive amine in HE resulting from chronic liver failure.
- [Show abstract] [Hide abstract] ABSTRACT: The binding parameters of [3H]SCH 23390 and [3H]spiperone (radioligands for dopamine D1 and D2 receptors, respectively) were investigated in autopsied frontal cortex, caudate nucleus and globus pallidus/putamen of cirrhotic patients who died in hepatic coma as well as in age- and sex-matched controls. Specific [3H]SCH 23390 binding site densities were unchanged in all regions; in contrast, specific [3H]spiperone binding site density was decreased (by 44%, P < 0.001) in the globus pallidus/putamen of patients with HE. Decreased densities of pallidal D2 binding sites could relate to the motor dysfunctions commonly encountered in human HE.
Article: Increased activities of MAO- A and MAO-B in autopsied brain tissue from cirrhotic patient with hepatic encephalopathy[Show abstract] [Hide abstract] ABSTRACT: Using radioenzymatic assays, activities of MAOA and MAOB were measured in autopsied brain tissue from cirrhotic patients who died in hepatic coma and in material from an equal number of age-matched subjects who were free from hepatic, neurological or psychiatric disorders. Activities of both MAOA and MAOB were significantly increased in frontal cortex and caudate nucleus, two brain regions shown previously to be the site of functional and morphological alterations of astrocytes and increased concentrations of the acid metabolites of dopamine and serotonin. These findings suggest that increased monoamine metabolism and subsequent modifications of monoaminergic synaptic function could contribute to the pathogenesis of hepatic encephalopathy.
Article: Increased densities of peripheral-type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy[Show abstract] [Hide abstract] ABSTRACT: Peripheral-type benzodiazepine receptors were evaluated using the specific ligand [3H]-PK 11195 in brain homogenates from nine cirrhotic patients who died in hepatic coma and from an equal number of age-matched control subjects. Histopathological studies showed evidence of severe Alzheimer type II astrocytosis in the brains of all cirrhotic patients. Saturation-binding assays revealed a single saturable binding site for [3H]-PK 11195 in brain, with affinities in the 2- to 3-nmol/L range. Diazepam was found to be a relatively potent inhibitor of 3H-PK 11195 binding (IC50 = 253 nmol/L), whereas the central benzodiazepine antagonist Ro 15-1788 displaced 3H-PK 11195 binding with low affinity (IC50 greater than 40 mumols/L). Densities of [3H]-PK 11195 binding sites were found to be increased by 48% (p less than 0.01) and 25% (p less than 0.05) in frontal cortex and caudate nuclei, respectively, from cirrhotic patients. Densities of [3H]-PK 11195 binding sites in frontal cortex from two nonencephalopathic cirrhotic patients were not significantly different from control values. No concomitant changes of affinities of these binding sites were observed. Because it has been suggested that peripheral-type benzodiazepine receptors may be localized on mitochondrial membranes and may therefore be involved in cerebral oxidative metabolism, the alterations observed in this study could be of pathophysiological significance in hepatic encephalopathy.
Article: Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. Neurochem. Res. 14:853-859[Show abstract] [Hide abstract] ABSTRACT: Alterations in the metabolism of monoamine neurotransmitters have been proposed to be involved in the development of the hepatic encephalopathy (HE) associated with experimental and human liver failure. In order to evaluate this hypothesis, the monoamines and some of their metabolites were measured in homogenates of caudate nucleus (CAU), prefrontal (PFCo) and frontal cortex (FCo) dissected from brains obtained at autopsy from nine cirrhotic patients who had died in hepatic coma and an equal number of control subjects, free from neurological, psychiatric and hepatic disorders, matched for age and time interval from death to freezing of autopsied brain samples. Monoamine measurements were performed by high-performance liquid chromatography with ion-pairing and electrochemical detection after a simple extraction procedure. In all three regions investigated, concentrations of dopamine (DA) were unchanged in cirrhotic patients vs controls while its metabolites, 3-methoxytyramine (3-MT) and homovanillic acid (HVA) were selectively affected i.e. 3-MT was found to be increased in CAU, while HVA levels were increased in FCo and CAU. DOPAC was also found to be unchanged in CAU. Noradrenaline (NA) levels were greatly increased in PFCo and FCo of cirrhotic patients but remained unchanged in CAU. No significant differences in the concentrations of either serotonin (5-HT) or of its precursor 5-hydroxytryptophan (5-HTP) were found in any of the three regions studied. However, 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, was increased in PFCo and CAU of cirrhotic patients. These findings show that selective alterations of catecholamine and 5-HT systems are involved in human HE and therefore, they may play an important role in the pathogenesis of certain neurological symptoms associated with this encephalopathy.
Article: Aromatic and branched-chain amino acids in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy[Show abstract] [Hide abstract] ABSTRACT: Concentrations of the branched-chain amino acids (BCAAs) valine, leucine, and isoleucine and the aromatic amino acids (AAAs) phenylalanine and tyrosine were measured in three areas of dissected brain tissue obtained at autopsy from nine cirrhotic patients who died in hepatic encephalopathy. The controls were an equal number of subjects free from neurological, psychiatric or hepatic diseases, matched for age and time interval from death to freezing of autopsied brain samples. Amino acids were measured using high-performance liquid chromatography with fluorimetric detection. In brain tissue of cirrhotic patients, no changes in BCAA concentrations were observed compared with controls. On the other hand, phenylalanine levels were found to be increased 141% in prefrontal cortex, 86% in frontal cortex and 26% in caudate nucleus, and tyrosine content was increased by 71% in prefrontal cortex and 28% in frontal cortex with no significant increase in caudate nucleus. Alterations in the concentration of AAAs may lead to disturbances of monoamine neurotransmitters in brain. Such changes could play a role in the pathogenesis of hepatic encephalopathy resulting from chronic liver disease in man.
Article: Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.Metab. Brain Dis. 2:283-290[Show abstract] [Hide abstract] ABSTRACT: Activities of the -aminobutyric acid (GABA) and cholinergic nerve-terminal marker enzymes glutamic acid decarboxylase (GAD) and choline acetyltransferase (CAT) as well as the astrocytic enzyme glutamine synthetase (GS) were measured in homogenates of dissected brain tissue obtained at autopsy from nine cirrhotic patients dying in hepatic encephalopathy and an equal number of control subjects matched for age, agonal status, and time interval from death to freezing of autopsied material. GAD activities varied as a function of agonal status in control samples, confirming a previous report, but were unchanged in brain tissue from cirrhotic patients, suggesting no loss of integrity of presynaptic GABA nerve terminals in this disease. On the other hand, GS activities were selectively decreased by 25% (P < 0.01)="" in="" caudate="" nuclei="" of="" cirrhotic="" patients,="" reflecting,="" no="" doubt,="" the="" severe="" astrocytosis="" consistently="" observed="" in="" this="" brain="" structure.="" cat="" activities,="" expressed="" per="" milligram="" of="" protein,="" were="" found="" to="" be="" increased="" by="" 30%="">P < 0.01)="" in="" the="" prefrontal="" cortex="" of="" cirrhotic="" patients.="" whether="" such="" changes="" result="" from="" a="" relative="" increase="" in="" cat="" as="" a="" consequence="" of="" losses="" of="" astrocytic="" protein="" or="" reflect="" altered="" cholinergic="" function="" in="" hepatic="" encephalopathy="" associated="" with="" chronic="" liver="" disease="" awaits="" further="">
Article: Amino Acid Changes in Autopsied Brain Tissue from Cirrhotic Patients with Hepatic Encephalopathy[Show abstract] [Hide abstract] ABSTRACT: Brain tissue was obtained at autopsy from nine cirrhotic patients dying in hepatic coma and from an equal number of controls, free from neurological, psychiatric, or hepatic diseases, matched for age and time interval from death to freezing of dissected brain samples. Glutamine, glutamate, aspartate, and gamma-aminobutyric acid (GABA) levels were measured in homogenates of cerebral cortex (prefrontal and frontal), caudate nuclei, hypothalamus, cerebellum (cortex and vermis), and medulla oblongata as their o-phthalaldehyde derivatives by HPLC using fluorescence detection. Glutamine concentrations were found to be elevated two- to fourfold in all brain structures, the largest increases being observed in prefrontal cortex and medulla oblongata. Glutamate levels were selectively decreased in prefrontal cortex (by 20%), caudate nuclei (by 27%), and cerebellar vermis (by 17%) from cirrhotic patients. On the other hand, GABA content of autopsied brain tissue from these patients was found to be within normal limits in all brain structures. It is suggested that such region-selective reductions of glutamate may reflect loss of the amino acid from the releasable (neurotransmitter) pool. These findings may be of significance in the pathogenesis of hepatic encephalopathy resulting from chronic liver disease.
- [Show abstract] [Hide abstract] ABSTRACT: Measurement of amino acids in brain tissue obtained at autopsy from cirrhotic patients dying in hepatic coma revealed a threefold increase in glutamine and a concomitant decrease in brain glutamate. The GABA levels were found to be unaltered. Studies using an animal model of portal-systemic encephalopathy gave similar results. Glutamic acid decarboxylase (GAD) activities were within normal limits, both in the brains of cirrhotic patients and portocaval-shunted rats. A previous study reported normal [3H]GABA binding to synaptic membrane preparations from cerebral cortex in these animals. Taken together, these findings suggest that cerebral GABA function is not impaired in hepatic encephalopathy associated with chronic liver disease and portal-systemic shunting. On the other hand, there is evidence to suggest that the releasable pool ofglutamate may be depleted in brain in hepatic encephalopathy. Data consistent with this hypothesis include: (i) Reduction in the evoked release of endogenous glutamate by superfusion of hippocampal slices with pathophysiological levels of ammonia; (ii) ammonia-induced reduction of glutamatergic neurotransmission; and (iii) an increase in the number of [3H]glutamate binding sites in synaptic membrane preparations from hyperammonemia rats and from rats with portocaval shunts. Such neurochemical changes may be of pathophysiological significance in hepatic encephalopathy.
Article: Ammonia: Key factor in the pathogenesis of hepatic encephalopathy.Neurochem. Pathol. 6: 1-12[Show abstract] [Hide abstract] ABSTRACT: There is substantial clinical and experimental evidence to suggest that ammonia toxicity is a major factor in the pathogenesis of hepatic encephalopathy associated with subacute and chronic liver disease. Ammonia levels in patients with severe liver disease are frequently found to be elevated both in blood and cerebrospinal fluid (csf). Hepatic encephalopathy results in neuropathological damage of a similar nature (Alzheimer type II astrocytosis) to that found in patients with congenital hyperammonemia resulting from inherited defects of urea cycle enzymes. Following portocaval anastomosis in the rat, blood ammonia concentration is increased 2-fold, and brain ammonia is found to be increased 2–3-fold. Administration of ammonia salts or resins to rats with a portocaval anastomosis results in coma and in Alzheimer type II astrocytosis. Since the CNS is devoid of effective urea cycle activity, ammonia removal by brain relies on glutamine formation. Cerebrospinal fluid and brain glutamine are found to be significantly elevated in cirrhotic patients with encephalopathy and in rats following portocaval anastomosis. In both cases, glutamine is found to be elevated in a region-dependent manner. Several mechanisms have been proposed to explain the neurotoxic action of ammonia. Such mechanisms include: (i) Modification of blood-brain barrier transport; (ii) alterations of cerebral energy metabolism; (iii) direct actions on the neuronal membrane; and (iv) decreased synthesis of releasable glutamate, resulting in impaired glutamatergic neurotransmission.
Top Journals
- Metabolic Brain Disease (6)
- Journal of Neurochemistry (2)
- Hepatology (2)
- Neurochemical Pathology (2)
- Hepatology (2)


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School of Material
Dean of School
School of Material pursues innovation and development through thinking and
practice that models future needs and their solutions, adapting from the known
and creating new possibilities. Key strategies include stretching the use of
traditional techniques and materials to and beyond their limits; the scientific
exploration of new materials; the cross-fertilisation of existing and new
technologies; and the generation of new forms. We believe it is a challenging
and exciting time to be working with material, as students, researchers and
Research Leader
Research across the School of Material is supported by a shared ethos of experimentation and innovation in design, studio practice and technology. Each programme in the School has a distinct identity, informed in part by the inherent differences between the specific materials they focus on. The common thread is in the importance of the qualities of materials in all the objects being created.
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Fishing and hunting report for March 13, 2011
Henshaw: Crappie starting to bite, with anglers fishing the 150-foot Fishing Float catching them off that. Lyle Daniels, Santa Ysabel, 35 crappie, averaging 1-pound each. John McDonald, Long Beach, 8 crappie averaging a half-pound each. Very good hiking nearby in the Palomar Mountain Range and foothills. Lake shoreline is good to walk on the west and northern sides. Open daily.
Hodges: The 184 anglers checked reported 82 bass released (none kept), 6 bluegill and 4 crappie. Open Wednesday, Saturday and Sunday. Network of trails includes the San Dieguito River Park and a pedestrian bridge connecting the south and north shores in the eastern part of the lake.
Jennings: Bass fishermen finding bedding fish all around the lake. Trout bite has been good for anglers on the Fishing Float. Best bait is an orange Power Worm with half of a night crawler. Trollers slow-trolling that combination also scoring. Another 1,000 pounds of Sierra 'Bows will be added this week. Great hiking opportunities on perimeter road and on trails. Camping available at the campground on the west side of the lake. Good camping weather ahead. Open Friday, Saturday and Sunday. Check www.lakejennings.com. Great hiking opportunities on perimeter road and on trails. Open Friday, Saturday and Sunday. But the lake will be open every day between Christmas and Jan. 2. Check www.lakejennings.org for more information.
Lindo Lake: Lakeside fishery has mostly channel catfish and carp, but some bass and bluegill. Gets stocked in the winter by the DFG. Getting stocked this week by the DFG.
Loveland: Open daily to hike-in fishing only on a limited area of shoreline. No permits required. Fishing license is required. There's a 140-foot fishing pier on the west side of the fishing cove.
Miramar: Lake received its last plant of rainbows this week from the Chalk Mound Trout Ranch in Nebraska. Very big trout biting here. The 86 anglers reported 10 bass kept (16 bass released), 72 trout, with the largest a 12.76-pounder caught by Mike Gilbert. He used a small plastic worm. Vehicles may be driven to the north shore of the lake Saturdays through Tuesdays. Perimeter road is paved and used by walkers, runners, rollerbladers and bicyclists. Very crowded on weekends. Picnic area on the southeast side of the lake and a few spots on the northwest shore. Pay fees at iron ranger or electronic pay station near the concession building. No boat rentals. Launch ramp for private boats is open.
Morena: Really good fishing this week, according to lake ranger Beryl Buchanan. Anglers landing Mt. Lassen and DFG trout. Bruce Chadwell, Campo, 11-4 trout, Power Bait, Paradise Cove. Brian Scott, Campo, 9-2 trout, crankbait, trolling in the middle of the lake. Chadwell's daughter, Shannon, caught a 9-pounder. Michael McCarthy, Ramona, 7-8 trout, Rapala, Dam area. Marc Rice, San Diego, 7-4 trout, Paradise Cove, green Power Bait. Jaden Kellogg, limit of trout, including a 5-pound, 6-ouncer, Horseshoe Cove. Bass anglers report fair bite on bass. They're hitting Texas-rigged plastic worms worked very, very slowly. Catfish are being landed, also, by anglers going for trout with Power Bait and night crawlers. The DFG stocks trout this week, so fishing should stay very good here. Boat launching is open for private boats. The speed limit is 10 mph. Before launch all boats are subject to quagga inspection. If you do not pass inspection you will not be able to launch. The launch fee is $6 for motorboats, kayaks, canoes, and sailboards. No licenses available here. You need to buy your fishing license prior to traveling to Morena. Good hiking around the lake. Also, the Pacific Crest Trail, which starts south of Campo at the U.S. Mexican border, cuts through the eastern side of the park. Great campground.


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Black Bean Quesadillas
From EatingWell: July/August 2010
In a hurry? These satisfying quesadillas take just 15 minutes to make. We like them with black beans, but pinto beans work well too. If you like a little heat, be sure to use pepper Jack cheese in the filling. Serve with: A little sour cream and a mixed green salad.
Makes: 4 servings
Active Time:
Total Time:
Nutrition Profile
Low cholesterol | High calcium | High fiber | High potassium |View Our Nutrition Guidelines »
- 1 15-ounce can black beans, rinsed
- 1/2 cup shredded Monterey Jack cheese, preferably pepper Jack
- 1/2 cup prepared fresh salsa (see Tip), divided
- 4 8-inch whole-wheat tortillas
- 2 teaspoons canola oil, divided
- 1 ripe avocado, diced
- Combine beans, cheese and 1/4 cup salsa in a medium bowl. Place tortillas on a work surface. Spread 1/2 cup filling on half of each tortilla. Fold tortillas in half, pressing gently to flatten.
- Heat 1 teaspoon oil in a large nonstick skillet over medium heat. Add 2 quesadillas and cook, turning once, until golden on both sides, 2 to 4 minutes total. Transfer to a cutting board and tent with foil to keep warm. Repeat with the remaining 1 teaspoon oil and quesadillas. Serve the quesadillas with avocado and the remaining salsa.
Tips & Notes
- Look for prepared fresh salsa in the supermarket refrigerator section near other dips and spreads.
Per serving: 377 calories; 16 g fat (5 g sat, 8 g mono); 13 mg cholesterol; 46 g carbohydrates; 0 g added sugars; 13 g protein; 10 g fiber; 679 mg sodium; 581 mg potassium.
Nutrition Bonus: Calcium (25% daily value), Folate (23% dv), Iron (19% dv), Potassium (17% dv).
Carbohydrate Servings: 2 1/2
Exchanges: 2 1/2 starch, 1 1/2 lean meat, 2 fat
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Recipe Categories
- Health & Diet Considerations
- High calcium
- High fiber
- High potassium
- Low cholesterol
- Total Time
- 15 minutes or less
- Servings
- 4
- Main Ingredient
- Beans/Legumes
- Meal/Course
- Snack
- Appetizers
- Dinner
- Preparation/ Technique
- Saute
- Type of Dish
- Appetizer
- Main dish, vegetarian
- Ease of Preparation
- Easy
- Publication
- July/August 2010


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Rated 5 out of 5 by Accountant Good Hot Sauce Tasty, good value and timely shipping. One bottle broken during shipping, but quickly replaced. July 11, 2013
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They'll think you're hot stuff, until they get close, that is. The Wanna Nookie Adult Costume is a fun and ridiculous costume for any party, but especially a luau or beach themed one. The costume features an oversized stuffed tunic that looks like a bikini and grass skirt on a woman's ample figure. Turn yourself into a hula dancer or beach girl. The suit is skin colored, so you'll just look large and shapely. The colorful Hawaiian print bikini covers the large chest and hips and the long grass skirt covers the front of the body. Pick up luau accessories separately, like leis, flip flops, and a ukelele. To really make the look, get a wig and maybe some makeup, also sold separately. Then, to make the look even more silly, make sure you don't shave. You'll have all the guys hitting on you.
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Corn emergence problems on side-hill seeps
By Roger Elmore and Mahdi Al-Kaisi
Iowa State University
Iowa's wet spring and cool temperatures not only slowed planting progress but also slowed Growing Degree Day accumulations. These factors contributed to yellow corn plants across the state as well as within-row variability in plant to plant growth and development. Seedling diseases reduced stands.
We might expect all of those problems to surface considering the conditions the crop has experienced to date. We expect stand losses in low areas of fields in wet years due to prolonged standing water on planted or emerged corn (see link). However, one rarely-seen problem has developed: corn stand losses on side hills.
Saturated soils on sloped areas with corn planted in the 2nd or 3rd week in May resulted in poor germination and damping off and in some cases dramatically reduced stands. Soil temperatures at and soon after planting were conducive for rapid germination and emergence. So, we can rule out temperature as a causal agent. In some cases the seed swelled (imbibed water) but neither the radical nor mesocotyl emerged. In cases where the radical and/or mesocotyl did emerge, they died before much growth occurred (colleagues at the Plant and Insect Diagnostic Clinic are examining seedlings for pathogens as we write).
One of the possible reasons for stand losses on side slopes is water seepage leading to continuously saturated conditions and thus a lack of oxygen supply for seedling to develop. Areas with water seepage like this are called 'side-hill seeps.'
Field with reduced stands on side hills due to saturated soils (foreground and just below the crest of the hill in the background). The field slopes down in the foreground to the lowest area – which ponded and has no surviving plants – and then back up the other side. Boone County, 11 June 2013.
One of the main reasons for side-hill seeping is an impermeable layer or clay-pan layer that restricts vertical water movement into the soil profile. This impermeable layer probably lies just below the area where the emergence failure occurred. This causes lateral water movement towards the back slope and creates saturated surface soil conditions.
Extensive spring 2013 precipitation fostered ideal conditions for side-hill seeps. Soil profiles were saturated and excess water moved laterally due to vertical flow restriction. This soil saturation occurred during critical stages of germination and early stages of growth. These conditions deprived seedlings oxygen necessary for growth and/or slowed growth to the point where pathogens were able to overcome the struggling seedlings. Corn stands were compromised.
Two seeds…no seedlings likely due to saturated soils in a side-hill seep area. Boone County, 11 June 2013.


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gladys_ortiz86's Mom Answers Activity
gladys_ortiz86 is a star in these topics:
Pregnancy > Giving Birth (3 helpful answers)
Is this normal? 39 weeks, haven't dropped, no dilation, baby over 7 lbs!?
Most recent answer (04/03/2015):
im 38 weeks i havve dropped but my cervix hasn't gotten thinner or dilated . ive heard that sex helps with thinning it out because of...posted by isune1


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Majority Backs PM's Unilateral Disengagement Plan
A clear majority of Israelis favors Prime Minister Ariel Sharon's "unilateral disengagement" outline for separation from the Palestinians, but doubts that Sharon truly intends to carry it out, according to an opinion poll released Thursday.
Sharon, announcing the plan in a speech a week ago, said he would begin implementing it in a few months if it became evident the Palestinian Authority was not undertaking its commitments in the road map and that some elements in the plan - which he dubbed a security, not a political, measure - could begin even sooner.
He said the plan includes redeployment of the IDF along a "security line" in the territories, and evacuation of isolated settlements that Sharon said would in any case not be included in Israeli territory in any future settlement. At the same time, Israel will strengthen its control over "those parts of the Land of Israel that will be an inseparable part of the state of Israel in any future settlement."
The poll, commissioned by Israel Radio, showed that 59 percent of respondents said they supported the plan. Among voters of Sharon's Likud, however, backers barely outnumbered opponents, 41 to 38 percent.
Many of those who backed the plan were skeptical whether Sharon would or could carry it out, the radio said.
Asked if they supported the evacuation of Migron, an illegal but strongly established outpost near the West Bank city of Ramallah, 54 percent of recipients said they did.
Among Likud voters, a majority was opposed to taking down the outpost. Fully 91 percent of voters of the rightist National Religious Party and the National Union faction opposed the move, but a majority believed that the rightist parties would remain in the coalition even if Migron were evacuated.
The poll also showed a strong 60 to 70 majority opposing soldiers' refusal to obey orders, whether ordered to serve in the territories or to evacuate settlements.
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Summer Youth Bus Pass Only $15
- Unlimited rides for 3 months
- For youth ages 5–18
- Valid from May 23–Aug. 31
StarTran, the City of Lincoln's bus system, is offering youth fun activities and unlimited transportation all summer with the StarPass. The StarPass is for youth ages 5-18, valid from May 23–August 31. This pass offers unlimited rides on StarTran buses and special discounts from participating sponsors all summer long.
Passes are now available at the StarTran Office, 710 "J" Street, and pass outlet locations. Call StarTran at 402-476-1234 for more information.
402-476-1234 startran.lincoln.ne.gov
lostinfun.com 25% off any one pass (Save up to $2.50) One offer per card. Not valid with parties or other promotions.
|10% off purchase of a helmet or tuneup 720 N. 27th St.
|FREE pie with any purchase at all Lincoln restaurants.
|402-464-7766 $1.00 off any cup
|10% discount off total purchase. Not valid with other offers. Lincoln locations only.
|FREE 6" sub with purchase of any size fountain drink. Cannot be combined with other offers and valid only at Lincoln locations.
|FREE 1/4 lb. hamburger with the purchase of medium fries and medium drink
|Joyo Theater
402-464-JOYO Buy one admission, get one admission FREE!
|15th & Cornhusker
402-434-7066 Buy one activity and get FREE game of Water Wars or Free Fall (2 buckets or 2 rides)
|KFCFREE Chicken Little.
|FREE mini 1-topping pizza with purchase of a soft drink at regular price. (Lincoln dine-in or carry-out only) Code 4909
|601 "R" Street, Suite 13015% off any purchase.
1420 "P" Street
402-477-4000 $1.00 off one child admission. Must be accompanied by a paid adult. Not valid with other discounts.
All Lincoln locations 50 cents off a 24 oz smoothie.
|www.sunvalleylanes.com Buy one game, get one FREE. Shoes not included and may not be combined with any other discount.
|FREE piece of fish or chicken.
|50¢ off a daily youth fee at any public pool. Not valid with other coupons or group admissions.
|Ager Golf Course
402-441-8963 Two golfers for the price of one, club/ball rental included.
www.lincolnlasertag.com Buy one laser tag session and get one FREE!
14th and Vine Streets $1.00 off one child admission. Must be accompanied by a paid adult. Not valid with any other offers.
|402-475-1111 FREE 20 oz. pop with the purchase of a mini pizza. Dine in or pick up only.
|amigoskings.com FREE cheesy burrito with purchase of a cheesy burrito.
|FREE value french fry with any sandwich purchase.
www.lincolnzoo.org Buy one regular priced admission, get second admission of equal or lesser value for $2.00 off. Excludes special events. No other discounts apply.
2016 StarPass Outlet Locations
- HyVee
- 50th & "O"
- 84th & Holdrege
- 27th & Superior
- 40th & Old Cheney
- Russ's
- 17th & Washington
- 66th & "O"
- Havelock
- 33rd & Hwy. 2
- Coddington & West "A"
- Carol Yoakum Family Resource Center
- Center for People in Need
- F Street Rec Center
- Good Neighbor Center
- Indian Center
- People City Mission


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If you take healthy steps, how far will you go? My Weight Loss Coach for Nintendo DS is a game for every adult, male and female, who considers reaching and maintaining their target weight a challenge. A program that fits your own objectives and respects your daily life constraints, My Weight Loss Coach supports you and tracks your progress and achievements by improving your energy balance. Developed in conjunction with a nutritionist, it helps you take control of your weight efficiently and feel better. Your motivation will increase with coaching sessions, daily challenges, mini-games and quizzes. Play for only 10 to 15 minutes per day and you will feel the difference! Game only, Pedometer not included.
This game was Pre-Owned. Any offers, bonus content and online play may not be available with the purchase of this product or may require additional fees.
Video Game Condition: Pre-Owned;
- Genre: Family
- Publisher: Ubisoft
other Info.
- Online Item #: 14525848
- Store Item Number (DPCI): 207-35-0192
- Imported


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News and Updates
Mettler-Toledo Calibration Week
Mettler-Toledo's next quarterly Calibration Week will take place August 1-5, 2016. To register, complete the Calibration Request Form by July 28.
If your lab has balances, scales, or pH meters, they can be maintained through Mettler-Toledo's calibration program. Mettler-Toledo can service a variety of models, including:
- Mettler-Toledo
- Acculab
- American Scientific Products
- Cahn
- Cardinal
- Denver
- Decto
- Digi
- Doran
- Fairbanks
- Fisher
- Ohaus
- Omnimark
- Pelouze
- Pennsylvania
- Perkin-Elmer
- Precisa
- Sartorius
- Sauter
- Sensor
- Setra
- Uline
- Uwe
Preventative maintenance includes cleaning, calibration, adjustments and minor repairs. Service is billed to your department/school chart string at $75 per unit.
To register for Calibration Week, complete the Calibration Request Form.
Download and print our May 2016 Calibration Week flyer to distribute and post in your department: Color | B&W
For more information on Mettler-Toledo, visit the Calibration Services page.


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Vermont gas prices downStaff Report | March 04,2013The price at the pump in Vermont fell 1.7 cents a gallon in the last week, averaging $3.83 a gallon, according to the latest GasBuddy.com survey of 626 gas outlets in the state.
The national average fell 2.8 cents a gallon to $3.70 gallon.
Gas prices in Vermont over the last week were 1.7 cents a gallon higher than the same day a year ago and are 10.8
cents a gallon higher than a month ago.
The national average increased 21.6 cents per gallon during the last month and stands 0.7 cents a gallon lower than a year ago.
GasBuddy.com senior petroleum analyst Patrick DeHaan said the current national average prices are now under year ago levels.
"And perhaps the best news is that the national average will likely continue to decline in most areas east of the Rockies in the week ahead as wholesale gasoline prices have given up ground," DeHaan said.
GasBuddy operates VermontGasPrices.com and more than 250 similar websites that track gasoline prices at more than 140,000 stations in the United States and Canada.MORE IN This Just InAnti-refugee activists are hosting a speaker at the Rutland Free Library tonight. Full StoryA Clarendon man pleaded innocent to his fourth DUI charge and a related charge in Rutland... Full StoryMan denies
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A Rutland man who was arrested Saturday night after... Full Story
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WWE 2005: Raising the Bar.
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Getting ignored by SCOTT STEINER
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Re: WWE 2005: Raising the Bar.
WWE Monday Night Raw Preview- 9/5/05- Little Rock, Arkansas, Alltel Arena
We are live from Little Rock, Arkansas this Monday night in what is sure to be a wild night for all the superstars of Monday Night Raw.
Last week saw the 2005 draft lottery and a lot of big moves occurred as Raw gained five new faces. The Big Show returned to Monday nights along with Doug and Danny Basham, Mark Jindrak and Charlie Haas. What kind of impact will these five make, if any, on their first night on Raw?
Also, last week, general manager Eric Bischoff announced a HUGE main event for tonights Raw. We will see the Game, the King of Kings, Triple H go one on one with Y2J, Chris Jericho with the winner going onto Vengeance to face Batista for the World Heavyweight championship. At Backlash, Jericho was cost the title by Mr.Money in the Bank, Edge. Will Jericho get another shot by beating The Game in Little Rock? Or will the 10 time World champion move one step closer to making it number 11?
Furthermore, tonight we are expecting to hear from Shawn Michaels after what went down during last weeks draft show. Michaels was praying that the draft see him and Kurt Angle on the same show but ultimately Michaels wish wasnt met and it now seems as though HBK wont be getting his shot at revenge on the Wrestling Machine. What will Michaels next move be and what will he have to say regarding the Angle situation?
We found out exactly who Muhammad Hassans new chronies were last week on Raw and they have certainly made a big impact since arriving on Monday nights. The Great Khali and Sonjay Dutt have joined forces with Hassan and Daivari to form the Arabian Entity. Last week the Entity got the upper hand yet again on Hassans rival, Shelton Benjamin. Benjamin however now has an ally, his former tag team partner, Charlie Haas was drafted last week and tonight on Raw The Worlds Greatest Tag Team will reunite and take on Daivari and Sonjay Dutt in tag team action. Will the Entity have the answers for the reuniting Haas and Benjamin this week?
Christian has had a big couple of weeks and with just one week now until Ric Flair returns to Raw, we are fully expecting Christian to address that situation here tonight. Captain Charisma has called Flair to answer his challenge and to face him one on one in order to pass the torch in Christians words. Christian has told Flair that one way or another he will get his hands on him, what will Christian threaten this week?
Confirmed for tonights Raw:
1 contenders match for the World title
Triple H vs. Chris Jericho
The Worlds Greatest Tag Team;
Shelton Benjamin and Charlie Haas
vs. The Arabian Entity;
Sonjay Dutt and Daivari w/Muhammad Hassan and The Great Khali
The show will be in recap as will all of Raw up until the Smackdown PPV, Judgment Day, Smackdown will be in full up til then. After Judgment Day itll be vice versa.
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Introduction to Image Stabilization and Techniques to Avoid Blur
Amateur photographers usually struggle with image stabilization and avoiding camera blur. But thanks to image stabilization technology, which generally comes built in the lenses or camera body of many DSLR cameras today,
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Q: I am really into my wildlife photography but cannot afford a super zoom lens, I have a 300mm and am considering a teleconvertor. Has anybody had a experience with these and would you recommend them?
A: Do you know?