text:
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Date: 1941
Description: Two women in Swiss costume, possibly for the Wilhelm Tell Festival.
Date: 1890 ca.
Description: Exterior view of the First Methodist Episcopal Church, built in 1887.
Date: date unknown
Description: The home farm of Thomas and Adeline Sears.
Date: 1950
Description: The Steinman residence, built in 1902, and owned by Christ Yuassi in 1950.
Date: 1945 ca.
Description: Turner Hall, a Swiss social center in Monroe.
Date: ????-06-13 date unknown
Description: Photographic postcard of the Sugar River. Elevated view of buildings and trees lining the shoreline. Two men can be seen standing next to the dam among a p...
Date: 1963
Description: Railroad freight station and siding, with railroad cars.
Date: 1924
Description: View down road lined with trees and storefronts. A number of automobiles can be seen parked. The Post Office is on the right.
Date: 1961
Description: Homemade decorative star wheel set curbside. The object consists of an assortment of pottery sherds and other discarded bits set in cement within a circula...
Date: 1856
Description: This map of Woodman's Addition in Mineral Point is pen-and-ink on paper.
The map includes certifications signed by John B. Whitelaw (surveyor), Cyrus Wood...
Description: A pedestrian path along a fence and road. There is a house in the distance.
Date: 1870 ca.
Description: West side view of the Courthouse Square with Hassinger & Chandler Dry Goods in the foreground.
Description: Laura Carney, the office bookkeeper of Brodhead Cheese, at her desk.
Description: Group of people in Swiss costume with large wheel of Swiss cheese, alpine horn and other instruments, and a St. Bernard in front of the Chalet of the Golde...
Date: 1950 ca.
Description: Usherettes perform Swiss folk dances for the annual William Tell Festival.
Date: 1960
Date: 1969
Description: A map of the Elroy-Sparta State Trail and the surrounding area, showing the townships, the towns of Cashton, Sparta, in the west, and Union Center and Elro...
Date: 1909
Description: View down Main Street of cars and shops lining both sides of the street. The buildings include: the Grand Central Hotel, an ice cream shop, and an automoti...
Description: View across dirt road of the exterior of the Brodhead High School.
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text:
Baixe o DLL-files Fixer e corrija facilmente os seus erros do registro.
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Data Manager
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datamngr.dll is a part of a software from bandoo media inc. It might technically not be a virus, but it exhibit many malicious traits, such as capabilities to hook deep into the operating system, browser hijacking, and interfering with your daily computer use. The industry generally refers to it as a "PUP".
datamngr.dll has been identified as the following threats;
"Bandoo media inc." is often bundled to freeware or shareware applications.
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Win XP, VISTA, 7:
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Win 8:
Press CTRL+SHIFT+ESC at the same time to bring up the Task Manager. Under the tab "Start-up", uncheck any boxes relating to datamngr.dll.
Should you not find any references here to the datamngr.dll , try the Microsoft program Sysinternals Autoruns. Available for free at: http://technet.microsoft.com/en-US/sysinternals/bb963902.aspx
This stops the error message. You may then proceed with your preferred malware cleaner, antivirus, removal tools, to remove the malicious software.
Also make sure to reset your internet browsers, making sure startpage and default search engine are not changed.
Como faço para instalar o arquivo DLL que eu baixei a partir de DLL-files.com?
Eu não consigo baixar os arquivos dll / eu recebo um "Link expirou", quando tento fazer download dos arquivos.
Como faço para substituir um arquivo em uso?
Quais são os requisitos de sistema para o DLL-Files Fixer?
Your website provided the dll files and easy instructions on where to place the files. The application now runs perfectly. Thank you so very, very much!

subset: commoncrawl


text:
The Portland Rose Festival reaches its apex Saturday with the 100th Grand Floral Parade. This year's parade will include 14 colorful floats incorporating the festival's theme, Rock 'n' Roses. Ninety other parade entries, from marching bands, including Heritage and Battle Ground high school bands, to llamas and vintage automobiles will hit the parade route. The parade will also be televised on Fox 12 from 6 a.m. to noon.
When: 10 a.m. Saturday.
Where: Starts at Veterans Memorial Coliseum, 300 N. Winning St., heads through downtown Portland across the Burnside Bridge, along Southwest Fourth Avenue to Southwest Taylor Street.
Admission: Reserved indoor and outdoor seating is available from $15-$30
Web: http://rosefestival.org.
The Grand Floral Parade is one of many options for getting out and about this weekend. Others include National Get Outdoors Day and a youth festival.
2. Find a gift and benefit museum
The Clark County Historical Museum will stage a unique benefit sale with autographed sports and celebrity memorabilia from the collection of Ron Zollo, with half of the proceeds going to the museum. Zollo, a former assistant general manager of the Tacoma Rainiers Pacific Coast League baseball franchise, has been collecting celebrity autographs for more than 30 years. Also enjoy the museum's current exhibits: "Above & Below the Fold: News Fit to Print" and "Mapping Clark County."
When: 10 a.m. to 4 p.m. Saturday.
Where: 1511 Main St., Vancouver.
Admission: Free.
Telephone: 360-993-5679
Web: http://cchmuseum.org
3. Get outdoors
The fourth-annual National Get Outdoors Day encourages family activities in open space at the Fort Vancouver National Site. Scale a climbing wall and test archery and disc golf skills on courses. Event highlights include Oregon Zoo Live Animals, information booths and photographs with Smokey Bear and friends. Explore Pearson Air Museum, which will celebrate the 100th anniversary of Silas Christofferson's 1912 flight off the roof of a Portland hotel, along with the recreated 1840s fur trapping camp and historic weapons demonstrations at the fort.
When: 9 a.m. to 5 p.m. Saturday
Where: Fort Vancouver National Site, 1501 E. Evergreen Blvd., Vancouver.
Admission: Free; Pearson admission: $7; $5 for seniors, active military members and students 6-17; free for 5 and younger; $22 for families.
Web: http://nps.gov/fova
4. The power of youth
The 11th-annual Camtown Youth Festival, hosted by Camas Parks and Recreation and the Camas School District, will offer children ages 3 to 16 a variety of activities, including carnival games, arts and crafts, face painting, an art show, a petting zoo and a chance to participate in the Kids Flea Market. There is a $4 fee for booth registration.
When: 11 a.m. to 4 p.m. Saturday.
Where: Crown Park, Northeast Everett Street and 17th Avenue, Camas.
Admission: Free.
Telephone: 360-834-5307.
Web: http://ci.camas.wa.us/parks.
5. 'Madagascar 3' a circus of laughs
Alex the Lion (voiced by Ben Stiller), Marty the Zebra (Chris Rock), Gloria the Hippo (Jada Pinkett Smith) and Melman the Giraffe (David Schwimmer) are still fighting to get back to their beloved Central Park Zoo. Their journey takes them to Europe, where they stumble on the perfect cover: a traveling circus that ends up spreading the animal's brand of comedic mayhem across the continent. "Madagascar 3: Europe's Most Wanted" is rated PG.
Where: Battle Ground Cinema, 1700 S.W. Ninth Ave., Battle Ground; Cinetopia, 11700 S.E. Seventh St.; Cintropia Vancouver Mall 23, 8700 N.E. Vancouver Mall Drive; various Regal Cinemas locations.
Admission: Varies by theater.
Telephone: Battle Ground Cinema, 360-666-7200; Cinetopia, 360-213-2800; Cinetopia Vancouver Mall 23, 360-448-4100; Regal Cinemas, 800-326-3264.
Web: http://www.battlegroundcinema.com, http://cinetopia.com or http://www.fandango.com.


text:
The Man Who Gave Us Mike Hammer
Crime writer Mickey Spillane died Monday at age 88. Spillane was most famous for his sex- and violence-drenched Mike Hammer detective novels. His titles include Kiss Me Deadly and I the Jury. While critics rarely praised Spillane, his books were bestsellers. This interview originally aired on Nov. 22, 1989.
Related NPR Stories
Spillane's Mark on Detective Fiction July 21, 2006
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Hi All, I developed some tools deeply based on UnifiesGenotyper Engine long time ago (GATK V1.5). Now I want to update some of my tools to GATK V2. But in Github source code, I can't find these walkers source code anymore... Are these code still public available, and when did they disappear? If they are still "alive" (open source..), could anyone tell me where they are?
In the previous very old version, it was under "org.broadinstitute.sting.gatk.walkers.genotyper.UnifiedGenotyper"
Thanks very much!!
Hi all,
How can I reverse engineer GATK framework? Also, how can I import the source code downloaded from github in eclipse?


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On January 25, the U.S. Court of Appeals for the D.C. Circuit held that appointments to the National Labor Relations Board (NLRB) made by President Obama in January 2012 during a purported Senate recess were unconstitutional, and vacated an order of the NLRB as constituted with those improperly appointed members. Noel Canning v. NLRB, No. 12-1115, slip. op (D.C. Cir. Jan. 25, 2013). The court, making a distinction between recesses generally and "the Recess" as used in the Constitution, held that the President can only make recess appointments during intersession recesses, and not during intrasession recesses. The court explained that the President's NLRB appointments were made during an intrasession recess, as the Senate was operating pursuant to a unanimous consent agreement that provided it would meet in pro forma sessions. Moreover, the court held that the President may only fill vacancies that arise or begin during such intersession recesses, as opposed to vacancies that happen to exist during such recesses. The court determined that the vacancies at issue here existed well before the recess. The court held that the appointments were constitutionally "invalid from their inception" and therefore the NLRB lacked a quorum to issue the NLRB order challenged on appeal. The court vacated the NLRB's order at issue. The President appointed CFPB Director Richard Cordray as a recess appointment on the same day the President appointed the NLRB members. Mr. Cordray's appointment is the subject of a lawsuit currently pending in the U.S. District Court for the District of Columbia.
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'Lion King' is Broadway's all-time box office king
Ginell points out that about 40 percent of "Phantom" tickets are sold to repeat customers, an extremely high number. Plus, 68 percent are women. "`Phantom is kind of a live-action romance novel," he said. "I think that's what's attracting a huge percentage of women to the show."
H. Todd Freeman, vice president of operations at ticket broker Applause Theatre & Entertainment Service, Inc., said the success of "The Lion King" is due to its family draw, big visuals and ticket prices that were double those for "Phantom" when it started.
Both shows now use premium pricing - offering deep-pocketed theatergoers the best seats for a hefty mark up. On Monday, both shows had top premium tickets of about $200. Even so, "The Lion King" still commands a higher average ticket price and shows no signs of softening.
"Will it make 25? I don't know," said Freeman, who admits he never thought rival "Phantom" would last this long. "It holds up pretty well all year long but the times when it is the strongest is the Christmas breaks, the Easter breaks, the Spring breaks and the summertime."
The two share some attributes: Both have musical giants behind them: "Phantom" has songs by Lloyd Webber and is directed by Harold Prince, while "The Lion King" features music by Elton John and lyrics by Tim Rice and the vision of Taymor.
Both have multiple Tony Awards, movie tie-ins, simple-to-understand stories and are spectacles - important for attracting tourists whose command of English might be weak. Both are not dependent on having stars on stage. And both call home in similar-sized theaters, "Phantom" at the 1,605-seat Majestic and "Lion" at the 1,677-seat Minskoff.
The staying power of each is remarkable. Over their first 750 playing weeks - which "The Lion King" has recently reached - they've played to roughly the same number of people: "The Lion King" at 10,092,235 and "Phantom" at 9,241,333.
Most shows that have achieved a ripe old age never appear in the top 10 by this point in their ages, but both "Lion" and "Phantom" are still routinely among the top earners, week in and week out. On the other side of the ledger, over 500 shows have opened and closed on Broadway during lifetime of "The Lion King."
Ginell tips his cap to the new box office king and doesn't see a time soon when it abandons its kingdom. "`Lion King' is the perfect family musical and I think it always will be as long as expenses don't go so far up that they won't be able to afford to put it on anymore."
"The Lion King": http://www.lionking.com
"Phantom of the Opera": http://www.thephantomoftheopera.com
Follow Mark Kennedy on Twitter at http://twitter.com/KennedyTwits
The Associated Press


text:
Months ago, our leadership council started planning a fundraising event for January Mentoring Month. In preparation, I emailed all the local nonprofits to see if others had events going on in January so we didn't pick the same night and compete with them. ...Wed, 12/18/2013 - 6:03pm
Homer Senior Citizen's Inc. wants to thank Coal Point, Gear Shed, The Bagel Shop, The Best Western, Upstairs Boutique, Sen. Mark Begich and Sen. Lisa Murkowski for donating to our 40th Year Anniversary Celebration and Open House. Your donations are greatly appreciated and helped us immensely with ...Wed, 12/18/2013 - 6:02pm
The Kachemak Ski Club would like to send a big thank you to all who came out to our recent Warren Miller fundraiser "Ticket to Ride." We are indebted to the Homer Bookstore for selling tickets and the Homer Theatre for providing us with a wonderful venue and staff. Many thanks to our generous lo...Wed, 12/18/2013 - 6:00pm
Those of us who knew Brother Asaiah (who left his body in 2000) were changed by his love and dedication to everyone who lived in our "Cosmic Hamlet by the Sea." It helps us to remember his love by his words in this season of love. • "Place thy soul before the great cosmic fireplace this Chri...Wed, 12/18/2013 - 5:57pm
For two weeks in November, the halls of Homer Middle School echoed with the rhythms of Latin music as students and teachers in PE classes learned the ins and outs and round-abouts of partner dancing. We'd like to thank our Artist in the Schools instructor, Eddie Wood, for sharing his experti...Wed, 12/11/2013 - 5:13pm
Pratt Museum would like to thank everyone in the community who participated in our holiday events this season. Thank you to all our amazing volunteers who helped make this year's Stocking Stuffer Party at the Pratt Museum a fun-filled day for the entire community. We would especially l...Wed, 12/11/2013 - 5:13pm
Thank you for all the kind words, flowers, cards and hugs at the loss of Brant Edens. He loved this town and the people here, and your outpouring of friendship during this time has meant so much to the family. We have enjoyed hearing your Brant stories and also hearing the stories of how you were wa...Wed, 12/11/2013 - 5:12pm
The students at Homer Flex want to thank all the people who attended the fundraiser for Doctors Without Borders to help the people in the Philippines. We were able to raise more than $500 to help this organization. Personally, I felt so empowered by this experience; our community has pulled to...Wed, 12/11/2013 - 5:10pm
Article 8, section 2 of the Alaska Constitution reads: "The Legislature shall provide for the utilization, development, and conservation of all natural resources belonging to the state, including land and waters, for the maximum benefit of its people." Article 8, section 1 reads: "It is the po...Wed, 12/04/2013 - 5:45pm
House Bill 77 is a corporate giveaway of Alaska's waters. The Alaska State Constitution states that "Wherever occurring in their natural state, fish, wildlife, and waters are reserved to the people for common use" (Article 8, Section 3). ...Wed, 12/04/2013 - 5:44pm
Homer News ©2016. All Rights Reserved.


text: Currently I own a Mac which is running with OS X Lion and Google Chrome version: 14.0.835.15 installed. In the most up-to-date dev edition of Google Chrome 2-finger swipe gesture lastly works for me, other than I by now would like to turn it off. The trouble is that I can't roll whichever content parallel any longer (particularly within developer tools), for the reason that Chrome keeps toggling pages in its place...Would it be achievable to lower compassion of this motion otherwise still better adjust?


text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 17, 2009
|Filing date
|Feb 16, 2005
|Priority date
|Feb 16, 2005
|Fee status
|Also published as
|Publication number
|Jan Weber, Brian J. Brown, Richard C. Gunderson, Susan Shoemaker
|Original Assignee
|Boston Scientific Scimed, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (11), Non-Patent Citations (1), Referenced by (12), Classifications (18), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
The present invention relates to medical appliances. More particularly, the present invention relates to drug-eluting external bodies and a method of incorporating a drug-eluting external body in a medical device.
Medical devices may be coated so that the surfaces of such devices have desired properties or effects. For example, it may be useful to coat medical devices to provide for the localized delivery of therapeutic agents to target locations within the body, such as to treat localized disease (e.g., heart disease) or occluded body lumens. Localized drug delivery may avoid some of the problems of systemic drug administration, which may be accompanied by unwanted effects on parts of the body which are not to be treated. Additionally, treatment of the afflicted part of the body may require a high concentration of therapeutic agent that may not be achievable by systemic administration. Localized drug delivery may be achieved, for example, by coating balloon catheters, stents and the like with the therapeutic agent to be locally delivered. The coating on medical devices may provide for controlled release, which may include long-term or sustained release, of a bioactive material.
Aside from facilitating localized drug delivery, medical devices may be coated with materials to provide beneficial surface properties. For example, medical devices are often coated with radiopaque materials to allow for fluoroscopic visualization while placed in the body. It is also useful to coat certain devices to achieve enhanced biocompatibility and to improve surface properties such as lubriciousness.
Coatings have been applied to medical devices by processes such as dipping, spraying, vapor deposition, plasma polymerization, spin-coating and electrodeposition. Although these processes have been used to produce satisfactory coatings, they have numerous, associated potential drawbacks. For example, it may be difficult to achieve coatings of uniform thicknesses, both on individual parts and on batches of parts. Further, many conventional processes require multiple coating steps or stages for the application of a second coating material, or may require drying between coating steps or after the final coating step.
The spray-coating method has been used because of its excellent features, e.g., good efficiency and control over the amount or thickness of coating. However, conventional spray-coating methods, which may be implemented with a device such as an airbrush, have drawbacks. For example, when a medical device has a structure such that a portion of the device obstructs sprayed droplets from reaching another portion of the device, then the coating becomes uneven. Specifically, when a spray-coating is employed to coat a stent having a tube-like structure with openings, such as stents described in U.S. Pat. Nos. 4,655,771 and 4,954,126 to Wallsten, the coating on the inner wall of the tube-like structure may tend to be thinner than that applied to the outer wall of the tube-like structure. Hence, conventional spraying methods may tend to produce coated stents with coatings that are not uniform. Furthermore, conventional spraying methods are inefficient. In particular, generally only 5% of the coating solution that is sprayed to coat the medical device is actually deposited on the surface of the medical device. The majority of the sprayed coating solution may therefore be wasted.
In the spin-dipping process, a medical device is coupled to a spinning device, and then, while rotating about a central axis, the medical device is dipped into a coating solution to achieve the desired coating. This process also suffers from many inefficiencies including the unevenness of the coated layer and a lack of control over the coated layer's thickness.
In addition to the spray coating and spin-dipping methods, the electrostatic deposition method has been suggested for coating medical devices. For example, U.S. Pat. Nos. 5,824,049 and 6,096,070 to Ragheb et al. mention the use of electrostatic deposition to coat a medical device with a bioactive material. In the conventional electrodeposition or electrostatic spraying method, a surface of the medical device is electrically grounded and a gas may be used to atomize the coating solution into droplets. The droplets are then electrically charged using, for example, corona discharge, i.e., the atomized droplets are electrically charged by passing through a corona field. Since the droplets are charged, when they are applied to the surface of the medical device, they will be attracted to the surface since it is grounded.
One disadvantage of conventional electrostatic spraying is that it requires a complicated spraying apparatus. In addition, because conventional electrostatic systems use a gas to move the droplets from a source to a target, controlling the gas pressure is crucial for accurate coating. However, it is not easy to control the gas pressure so that the target surface is evenly and sufficiently coated without losing much of the coating solution.
Another method of coating a device can be achieved with electrohydrodynamic spraying. Using this method, a gas is not needed to disperse the coating. Electrohydrodynamic coating is accomplished by forcing a compatible solution through a nozzle assembly that has been electrically charged. The coating solution passes through the charged nozzle where it is electrically charged. As the solution exits the nozzle, the solution atomizes as the charged particles repel each other. This action forms the spray mist. The charged particles are attracted to the device to be coated when the device is connected to an electrical ground.
Devices may be coated by a gas assisted spraying process. A polymer/drug combination may be dissolved in a solvent mixture. The solution may be sprayed onto the devices and a polymer/drug film may be formed when the solvents evaporate. The ability to apply thin coatings on products may be limited by the capabilities of a gas assisted spraying process. The coating may flow on the medical device prior to drying, thereby creating an uneven concentration of bioactive agent on the surface of the device. A gas assisted spraying process may have a high variability for thin coatings.
Conventional methods of coating stents or devices with a drug-polymer layer, such as spraying or dipping, may require a solution of the drug-polymer to physically wet the surface of the stent. Spraying or dipping may cause uneven and unpredictable wetting, and distribution and evaporation of the solvent molecules may result in a non-uniform coating. The drying of the coating may lead to cracking and/or points of stress in the coating. A non-uniform coating may lead to the unit failing agent release requirements, drug uniformity and coating thickness specifications.
During deployment and loading of self-expanding (SE) stents, there may be significant friction between the stent surface and the sheath. Longer stents may have higher friction forces. These shear forces may be especially damaging in relation to coated SE stents. As the application of drug eluting coatings allows the use of longer stents, the problems resulting from this frictional interaction may increase. Similarly, during deployment of balloon-expandable stents, there may be a significant friction between the unfolding balloon and the stent surface.
Additionally, due to the large weight of a stent in relation to a coating weight (with SIBS\paclitaxel coating weight to stent weight having a ratio of approximately 1 to 1000), it may be difficult to measure the exact amount of drug coating on a stent.
Furthermore, due to the complex shape of a stent, it may be difficult to produce a homogeneous uniform coating on the stent surface. Similarly, the deposition of a drug coating that has a predefined pattern over the stent surface (for example, a 20% increased drug concentration at both ends of the stent in order to anticipate edge effects) may be difficult.
There is, therefore, a need for a cost-effective method of linking drug release coatings to the medical device which is not sensitive to the loading and deployment forces. The method should assure defect-free coatings and uniform drug dose per unit device. The method would provide better control of the agent release profile of the device, including increasing or decreasing the release of the bioactive agent. The method would also improve the quality of the coating of the device by allowing drug concentration variations as well as different drugs on different parts of the device. The method would thus allow for better control of the sensitivity of the bioactive material and would reduce variations in the coating properties. Each of the references cited herein is incorporated by reference herein for background information.
A medical appliance is provided that includes a self-expanding stent; a sheath adapted to enclose the self-expanding stent in an interior space during deployment; and an external body comprising a bioactive agent attached to the self-expanding stent and adapted to lie outside the interior space of the sheath when the self-expanding stent is enclosed in the sheath.
The external body may be attached to a distal end of the self-expanding stent. The external body may be a membrane. The membrane may reside in an annular space in the sheath outside of the interior space when the self-expanding stent is enclosed in the interior space. The annular space in the sheath may be defined by an outer protective tube situated on an exterior of the sheath. Deploying the self-expanding stent may cause the membrane to be extracted from the annular space. The membrane may be impermeable to a fluid. The bioactive agent may include endothelial cells. The membrane may be porous to a fluid.
The external body may be a plurality of wires. Each of the plurality of wires may reside in a respective cylinder in the sheath outside of the interior space when the self-expanding stent is enclosed in the interior space. Deploying the self-expanding stent may cause each of the plurality of wires to be extracted from the respective cylinder. At least one of the plurality of wires may be a shape-memory wire. The shape-memory wire may be adapted to bend away from a central axis of the self-expanding stent. At least two of the plurality of wires may be connected to each other along at least a partial length of the two wires by a membrane.
The medical appliance may be deployed in a lumen of a human body and the external body may release the bioactive agent.
A medical device is provided that includes a tissue scaffold; a sheath adapted to enclose the tissue scaffold in an interior space during deployment; and an external body comprising endothelial cells attached to the tissue scaffold and adapted to lie outside the interior space of the sheath when the tissue scaffold is enclosed in the sheath.
The external body may be attached to a distal end of the tissue scaffold. The external body may be a membrane. The membrane may be non-porous. The external body may include a bioactive agent. The tissue scaffold may be a porous structure.
An exemplary embodiment of the present invention separates the drug coating from the SE stent by creating a system in which the drug is put on an additional element which is located either on the outside of the delivery sheath or inside the wall of the delivery sheath.
For example, a standard, bare SE stent may be loaded into a delivery sheath. A membrane or thin tube may be connected on the distal end of the SE stent and may be positioned on the outside of the delivery sheath. As the stent is unloaded out of the sheath, it will expand in the vessel while also expanding, at the same time, the drug membrane that will be located between the stent and the vessel wall. If the stent is pushed out of the delivery tube it will drag along the drug membrane, since the two are connected on the distal end. The drug membrane may experience no sheer force during this deploying operation and in particular no sheer force from the SE stent or the delivery sheath.
Since the drug membrane may be attached to the distal end of the SE stent after the SE stent has been loaded, there may be no sheer force on the drug membrane during the loading operation. An additional advantage may be that coating the drug membrane avoids the problem of coating a complex stent design.
Since the drug may be provided to the membrane without having the large mass of the stent in place, it may be possible to provide a much more accurate drug dose. For instance, a long polymer membrane may be extruded, coated on the outside with a drug, then cut to a required and/or desired length, and then weighed. If the drug dose exceeds the desired amount, an additional piece of membrane may be removed before attaching the membrane to the stent.
The drug membrane may be made either with or without holes to provide blood flow to side-branches. The membrane may be elastic so that it clamps itself to the sheath on the outside.
The delivery sheath may be modified to provide a chamber for the drug-infused membrane. For instance, in the situation of a very soft material being used for the outside drug membrane, a very thin outer protection tube may be added that is connected proximally to the delivery sheath. As the stent is pushed out of the sheath and is dragged along the drug membrane, it will drag the membrane out of its chamber between the delivery sheath and the outer protective element (the outer sheath).
Alternatively, wires may be used instead of a drug membrane. The wires may be coated in a material including a bioactive agent, weighed, and then attached to the distal end of the SE stent. The wires may rest against the outer surface of the delivery sheath or may be banded to the outside of the delivery sheath by a biodegradable and/or releasable band. Alternatively, channels may be extruded in the delivery sheath in which the drug-coated wires that are connected on the distal part to the SE stent may be inserted. This may result in a situation similar to the one described above, but instead of having a membrane in between the vessel wall and the stent, there will be a number of drug-loaded wires (or alternatively, hollow tubes) positioned between the SE stent and the vessel wall. Drug-coated wires provide complete access to the side-branch.
The wires may be longer than the actual stent, so that the drug eluting section of this employed system may extend beyond the SE stent itself. In a further exemplary embodiment, flat memory strips may be used with a shape memory to bend outward on the proximal end. The shape memory strips may comprise Nitinol. In this alternative exemplary embodiment, an SE stent may be positioned in the beginning of a side-branch vessel and have the drug wires (strips) bending out into the main vessel. Alternatively, an SE stent may be positioned in a main branch in the vicinity of a side-branch vessel and the drug wires (strips) may bend into the side-branch vessel.
An alternative exemplary embodiment combines both systems, membrane and wires, by having a number of polymer membrane rings on the outside of the sheath connected along the axis by wires and connected on the distal part to the stent.
An alternative exemplary embodiment utilizes a bucky paper tube (for instance a carbon nanotube or other variation of buckminsterfullerene) and/or a fiber network (for instance, metal, polymer or ceramic fibers) as the reservoir for the bioactive agent and/or as the external drug-eluting body. A fiber network of IrOx fibers may have a catalytic effect in transforming peroxide into oxide and hydrogen. In an alternative exemplary embodiment wire with a catalytic effect and other wires with a drug load (and possibly other wires made out of a highly radiopaque material) may be combined. Likewise, wire and membrane combinations having various properties in various components of the combination may also be possible.
In an alternative exemplary embodiment, magnetic wires may be utilized in conjunction with encapsulation technologies in which magnetic kernels may be surrounded by drugs in micro-capsules. The micro-capsules may be injected in the chamber in the wall of the delivery sheath or in between the delivery sheath and the protective outer sheath. During unloading of the stent from the delivery sheath, the bio-absorbable particles may be dragged along by magnetic forces. The particles may remain magnetically coupled to the magnetic wires and may release their drug-load over time.
Open (meshed) coverings, wires, or closed coverings may be used. Using open drug covered membranes may avoid blocking the bloodstream to side vessels and/or the blood supply to the vessel wall, and therefore may not need to be released fully before the expanding element is released. There may be only one actuating mechanism in the device, which may be a benefit in regards to space and safety. The open drug-releasing outer elements may allow deploying systems that do not block side-access.
Alternative exemplary methods of attaching an outer ePTFE sheath to one side of a self-expanding stent (for instance, a Sentinol stent) are possible. ePTFE may be fused to ePTFE by applying pressure at high temperatures (for example, 395 degrees Celsius).
It may be possible to attach the external body to the stent by using a procedure entailing outside air pressure applied to an assembly where an outer ePTFE covering is mounted on a stent, mounted on an inner covering, and mounted on a mandrel. A possible disadvantage of this method may be that the drug coating has to be applied to the covering after the covering has been attached to the stent, as a drug coating may be destroyed by the high temperatures. Coating the external body prior to attaching it to the stent may have certain benefits, including the ease of calculating the amount of bioactive agent by weighing due to the high ratio of bioactive agent to inert material in the weighing process.
An alternative exemplary embodiment provides a ring or small patches of ePTFE to the stent prior to loading. A separate external body may be coated with drugs over most or all of its surface, and solder-equipment or an infrared laser may be used to spot-weld the drug-coated external body to the ePTFE. The ePTFE may already be mounted to the stent.
Alternative exemplary embodiments may utilize glue to attach the drug-eluting external body to the stent.
The delivery system may be manufactured, by starting with an existing delivery catheter and grinding or laser ablating away the outer layer on the distal end to create a reduced diameter outer sheath. A second extruded thin tube may then be placed around this distal tip of the catheter and welded or glued to the catheter at the proximal side of the reduced diameter outer sheath area. The second extruded thin tube should have an inner diameter greater than the reduced diameter outer sheath area of the catheter in order to provide a gap.
In case of an aneurism, a robust sheath on the stent may be needed to keep the blood flow through the interior of the stent or other medical appliance. Some devices and grafts utilize Nitinol systems with ePTFE and/or polyester coverings. These devices may be loaded into a polymer delivery tube and pushed out during a procedure to close off the aneurism. An exemplary embodiment of the present invention may be used in conjunction with a conventional system for treating an aneurism by adding a drug-loaded external body (sheath or wires) outside of the conventional device.
In an alternative exemplary embodiment, the sheath material may be an electro-active polymer or combination of polymers.
A method of producing the medical device may include attaching an external body to a stent and coupling the stent to a delivery arrangement. The external body may include a bioactive agent. The external body may include a membrane and the method may include spot welding the membrane to the stent and inverting the membrane after attaching the membrane to the stent. The inverting operation may include moving a portion of the membrane opposite a point of attachment towards the point of attachment and further moving the portion of the membrane opposite the point of attachment to an exterior of the stent and towards a section of the stent distal to the point of attachment.
The stent may include a self-expanding stent and the delivery arrangement may include a delivery sheath for the self-expanding stent. The coupling operation may include inserting the self-expanding stent into the delivery sheath in a contracted state. The coupling operation may include situating the membrane on an exterior of the delivery sheath. The coupling operation may include situating the membrane in an annular space of the delivery sheath. The annular space may be situated in between a central space and an exterior of the delivery sheath.
The external body may include a plurality of wires. The stent may include a self-expanding stent. The delivery arrangement may include a delivery sheath for the self-expanding stent. The coupling operation may include inserting the self-expanding stent into the delivery sheath in a contracted state.
The coupling operation may include situating the plurality of wires on an exterior of the delivery sheath. The coupling operation may include situating each of the plurality of wires in a chamber in the delivery sheath. Each of the chambers may be situated in between a central space and an exterior of the delivery sheath. The plurality of wires may include a plurality of shape-memory wires. The delivery arrangement may include a balloon catheter.
As used herein, the term "therapeutic agent" includes one or more "therapeutic agents" or "drugs". The terms "therapeutic agents", "active substance" and "drugs" are used interchangeably herein and include pharmaceutically active compounds, nucleic acids with and without carrier vectors such as lipids, compacting agents (such as histones), viruses (such as adenovirus, andenoassociated virus, retrovirus, lentivirus and α-virus), polymers, hyaluronic acid, proteins, cells and the like, with or without targeting sequences.
The therapeutic agent may be any pharmaceutically acceptable agent such as a non-genetic therapeutic agent, a biomolecule, a small molecule, or cells.
Exemplary non-genetic therapeutic agents include antithrombogenic agents such heparin, heparin derivatives, prostaglandin (including micellar prostaglandin E1), urokinase, and PPack (dextrophenylalanine proline arginine chloromethyl ketone); antiproliferative agents such as enoxaparin, angiopeptin, sirolimus (rapamycin), tacrolimus, everolimus, monoclonal antibodies capable of blocking smooth muscle cell proliferation, hirudin, and acetylsalicylic acid; anti-inflammatory agents such as dexamethasone, rosiglitazone, prednisolone, corticosterone, budesonide, estrogen, estradiol, sulfasalazine, acetylsalicylic acid, mycophenolic acid, and mesalamine; antineoplastic/antiproliferative/antimitotic agents such as paclitaxel, epothilone, cladribine, 5-fluorouracil, methotrexate, doxorubicin, daunorubicin, cyclosporine, cisplatin, vinblastine, vincristine, endostatin, trapidil, halofuginone, and angiostatin; anticancer agents such as antisense inhibitors of c-myc oncogene; antimicrobial agents such as triclosan, cephalosporins, aminoglycosides, nitrofurantoin, silver ions, compounds, or salts; biofilm synthesis inhibitors such as non-steroidal anti-inflammatory agents and chelating agents such as ethylenediaminetetraacetic acid, O,O′-bis (2-aminoethyl)ethyleneglycol-N,N,N′,N′-tetraacetic acid and mixtures thereof; antibiotics such as gentamicin, rifampin, minocycline, and ciprofloxacin; antibodies including chimeric antibodies and antibody fragments; anesthetic agents such as lidocaine, bupivacaine, and ropivacaine; nitric oxide; nitric oxide (NO) donors such as linsidomine, molsidomine, L-arginine, NO-carbohydrate adducts, polymeric or oligomeric NO adducts; anticoagulants such as D-Phe-Pro-Arg chloromethyl ketone, an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, antithrombin antibodies, antiplatelet receptor antibodies, enoxaparin, hirudin, warfarin sodium, dicumarol, aspirin, prostaglandin inhibitors, platelet aggregation inhibitors such as cilostazol and tick antiplatelet factors; vascular cell growth promoters such as growth factors, transcriptional activators, and translational promoters; vascular cell growth inhibitors such as growth factor inhibitors, growth factor receptor antagonists, transcriptional repressors, translational repressors, replication inhibitors, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, bifunctional molecules consisting of an antibody and a cytotoxin; cholesterol-lowering agents; vasodilating agents; agents which interfere with endogenous vascoactive mechanisms; inhibitors of heat shock proteins such as geldanamycin; and any combinations and prodrugs of the above.
Exemplary biomolecules include peptides, polypeptides and proteins; oligonucleotides; nucleic acids such as double or single stranded DNA (including naked and cDNA), RNA, antisense nucleic acids such as antisense DNA and RNA, small interfering RNA (siRNA), and ribozymes; genes; carbohydrates; angiogenic factors including growth factors; cell cycle inhibitors; and anti-restenosis agents. Nucleic acids may be incorporated into delivery systems such as, for example, vectors (including viral vectors), plasmids or liposomes.
Non-limiting examples of proteins include monocyte chemoattractant proteins ("MCP-1") and bone morphogenic proteins ("BMPs"), such as, for example, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6 (Vgr-1), BMP-7 (OP-1), BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15. Preferred BMPS are any of BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, and BMP-7. These BMPs can be provided as homodimers, heterodimers, or combinations thereof, alone or together with other molecules. Alternatively, or in addition, molecules capable of inducing an upstream or downstream effect of a BMP can be provided. Such molecules include any of the "hedghog" proteins, or the DNA encoding them. Non-limiting examples of genes include survival genes that protect against cell death, such as anti-apoptotic Bcl-2 family factors and Akt kinase and combinations thereof. Non-limiting examples of angiogenic factors include acidic and basic fibroblast growth factors, vascular endothelial growth factor, epidermal growth factor, transforming growth factor α and β, platelet-derived endothelial growth factor, platelet-derived growth factor, tumor necrosis factor α, hepatocyte growth factor, and insulin like growth factor. A non-limiting example of a cell cycle inhibitor is a cathespin D (CD) inhibitor. Non-limiting examples of antirestenosis agents include p15, p16, p18, p19, p21, p27p53, p57Rb, nFkB and E2F decoys, thymidine kinase ("TK") and combinations thereof and other agents useful for interfering with cell proliferation.
Exemplary small molecules include hormones, nucleotides, amino acids, sugars, and lipids and compounds that have a molecular weight of less than 100 kD.
Exemplary cells include stem cells, progenitor cells, endothelial cells, adult cardiomyocytes, and smooth muscle cells. Cells can be of human origin (autologous or allogeneic) or from an animal source (xenogeneic), or genetically engineered. Non-limiting examples of cells include side population (SP) cells, lineage negative (Lin−) cells including Lin−CD34−, Lin−CD34+, Lin−c Kit+, mesenchymal stem cells including mesenchymal stem cells with 5-aza, cord blood cells, cardiac or other tissue derived stem cells, whole bone marrow, bone marrow mononuclear cells, endothelial progenitor cells, skeletal myoblasts or satellite cells, muscle derived cells, GΠ cells endothelial cells, adult cardiomyocytes, fibroblasts, smooth muscle cells, adult cardiac fibroblasts +5-aza, genetically modified cells, tissue engineered grafts, MyoD scar fibroblasts, pacing cells, embryonic stem cell clones, embryonic stem cells, fetal or neonatal cells, immunologically masked cells, and teratoma derived cells.
Any of the therapeutic agents may be combined to the extent such combination is biologically compatible.
Any of the above mentioned therapeutic agents may be incorporated into a polymeric coating on the medical device or applied onto a polymeric coating on a medical device. The polymers of the polymeric coatings may be biodegradable or non-biodegradable. Non-limiting examples of suitable non-biodegradable polymers include polystyrene; polyisobutylene copolymers and styrene-isobutylene-styrene block copolymers such as styrene-isobutylene-styrene tert-block copolymers (SIBS); polyvinylpyrrolidone, including cross-linked polyvinylpyrrolidone; polyvinyl alcohols, copolymers of vinyl monomers such as EVA; polyvinyl ethers; polyvinyl aromatics; polyethylene oxides; polyesters including polyethylene terephthalate; polyamides; polyacrylamides; polyethers including polyether sulfone; polyalkylenes including polypropylene, polyethylene and high molecular weight polyethylene; polyurethanes; polycarbonates, silicones; siloxane polymers; cellulosic polymers such as cellulose acetate; polymer dispersions such as polyurethane dispersions (BAYHYDROL�); squalene emulsions; and mixtures and copolymers of any of the foregoing.
Non-limiting examples of suitable biodegradable polymers include polycarboxylic acid, polyanhydrides including maleic anhydride polymers; polyorthoesters; poly-amino acids; polyethylene oxide; polyphosphazenes; polylactic acid, polyglycolic acid and copolymers and mixtures thereof such as poly(L-lactic acid) (PLLA), poly(D,L,-lactide), poly(lactic acid-co-glycolic acid), 50/50 (DL-lactide-co-glycolide); polydioxanone; polypropylene fumarate; polydepsipeptides; polycaprolactone and copolymers and mixtures thereof such as poly(D,L-lactide-co-caprolactone) and polycaprolactone co-butyl acrylate; polyhydroxybutyrate valerate and blends; polycarbonates such as tyrosine-derived polycarbonates and acrylates, polyiminocarbonates, and polydimethyltrimethylcarbonates; cyanoacrylate; calcium phosphates; polyglycosaminoglycans; macromolecules such as polysaccharides (including hyaluronic acid; cellulose, and hydroxypropylmethyl cellulose; gelatin; starches; dextrans; alginates and derivatives thereof), proteins and polypeptides; and mixtures and copolymers of any of the foregoing. The biodegradable polymer may also be a surface erodable polymer such as polyhydroxybutyrate and its copolymers, polycaprolactone, polyanhydrides (both crystalline and amorphous), maleic anhydride copolymers, and zinc-calcium phosphate.
Such coatings used with the present invention may be formed by any method known to one in the art. For example, an initial polymer/solvent mixture can be formed and then the therapeutic agent added to the polymer/solvent mixture. Alternatively, the polymer, solvent, and therapeutic agent can be added simultaneously to form the mixture. The polymer/solvent mixture may be a dispersion, suspension or a solution. The therapeutic agent may also be mixed with the polymer in the absence of a solvent. The therapeutic agent may be dissolved in the polymer/solvent mixture or in the polymer to be in a true solution with the mixture or polymer, dispersed into fine or micronized particles in the mixture or polymer, suspended in the mixture or polymer based on its solubility profile, or combined with micelle-forming compounds such as surfactants or adsorbed onto small carrier particles to create a suspension in the mixture or polymer. The coating may comprise multiple polymers and/or multiple therapeutic agents.
The coating can be applied to the medical device by any known method in the art including dipping, spraying, rolling, brushing, electrostatic plating or spinning, vapor deposition, air spraying including atomized spray coating, spray coating using an ultrasonic nozzle, and polyelectrolyte coating (layer by layer).
The coating is typically from about 1 to about 50 microns thick. In the case of balloon catheters, the thickness is preferably from about 1 to about 10 microns, and more preferably from about 2 to about 5 microns. Very thin polymer coatings, such as about 0.2-0.3 microns and much thicker coatings, such as more than 10 microns, are also possible. It is also within the scope of the present invention to apply multiple layers of polymer coatings onto the medical device. Such multiple layers may contain the same or different therapeutic agents and/or the same or different polymers. Methods of choosing the type, thickness and other properties of the polymer and/or therapeutic agent to create different release kinetics are well known to one in the art.
The medical device may also contain a radio-opacifying agent within its structure to facilitate viewing the medical device during insertion and at any point while the device is implanted. Non-limiting examples of radio-opacifying agents are bismuth subcarbonate, bismuth oxychloride, bismuth trioxide, barium sulfate, tungsten, and mixtures thereof.
Non-limiting examples of medical devices according to the present invention include catheters, guide wires, balloons, filters (e.g., vena cava filters), stents, stent grafts, vascular grafts, intraluminal paving systems, implants and other devices used in connection with drug-loaded polymer coatings. Such medical devices may be implanted or otherwise utilized in body lumina and organs such as the coronary vasculature, esophagus, trachea, colon, biliary tract, urinary tract, prostate, brain, lung, liver, heart, skeletal muscle, kidney, bladder, intestines, stomach, pancreas, ovary, cartilage, eye, bone, and the like.
While the present invention has been described in connection with the foregoing representative embodiment, it should be readily apparent to those of ordinary skill in the art that the representative embodiment is exemplary in nature and is not to be construed as limiting the scope of protection for the invention as set forth in the appended claims.
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Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WEBER, JAN;BROWN, BRIAN J.;GUNDERSON, RICHARD C.;AND OTHERS;REEL/FRAME:016281/0646;SIGNING DATES FROM 20050117 TO 20050119
|Jul 18, 2012
|Fee payment
Year of fee payment: 4


text:
I have a system that contains below configurationss:
- CPU:Intel Core i5-2500K
- Motherboard:Asus s1155 P8Z68-V PRO/GEN3
- RAM:Corsair Vengeance 8GB Dual Channel DDR3
- HDD:Western Digital 500GB SATAIII
- PSU:FSP Aurum Gold 600W
- Sony Optiarc AD-7280S DVD+/-RW.
NOw i catch problem on this well worked system when i attach MSI N560GTX-Ti Hawk grpahics card. Whenever i connect this card and reboot my windows 7, it shows blue screen. I never expect such kind of things on my system. I tried to start it in safe mode, reconnection, driver installtion but not worked. Hence, here i am expecting that few good reply comes so that i can connect it to my system. Thanks for any such help.


text:
Stream it now
Magic City 2012
Centers on Miami mobsters and other characters from Miami Beach in the late 1950s...
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- Ed Bianchi, Simon Cellan Jones, David Petrarca, Carl Franklin, Nick Gomez, Clark Johnson, Terrence O'Hara ...
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Ike and Ben's future hangs in the balance as the casino gambling bill comes to a final vote. Ike makes Klein a tempting offer, and Sy makes a final decision about Ben. Victor recognizes a
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July 26, 2013 Episode 6 Sitting on Top of the World 7 links
July 19, 2013 Episode 5 World in Changes 5 links
July 12, 2013 Episode 4 Crossroads 4 links
June 28, 2013 Episode 3 Adapt or Die 4 links
June 21, 2013 Episode 2 Angels of Death 4 links
June 14, 2013 Episode 1 Crime and Punishment 8 links
Season 1
June 1, 2012 Episode 8 Time and Tide 5 links
May 18, 2012 Episode 7 Who's the Horse and Who's the Rider? 5 links
May 11, 2012 Episode 6 The Harder They Fall 4 links
May 4, 2012 Episode 5 Suicide Blonde 5 links
April 20, 2012 Episode 3 Castles Made of Sand 2 links
April 13, 2012 Episode 2 Feeding Frenzy 2 links
March 30, 2012 Episode 1 The Year of the Fin 4 links
September 1, 2012 Episode 0 Starz Studios Presents Magic City 0 links You have a link?
Flicker2013 L over 2 years ago reply report
Magic City (2012)
Release Date: (March 30, 2012 (US))
Schedule: (Friday, 10:00 PM on Starz)
Genre: (Drama, Mystery, Crime)
Stars: Jeffrey Dean Morgan, Olga Kurylenko, Steven Strait, Jessica Marais, Christian Cooke, Elena Satine, Dominik Garcia-Lorido, Taylor Blackwell, and Danny Huston.
Centers on Miami mobsters and other characters from Miami Beach in the late 1950s. As Ike Evans rings in the New Year at his luxurious Miramar Playa Hotel, Havana falls to Fidel Castro. He is forced to make an ill-fated deal with Miami mob boss Ben Diamond to ensure the success of his glitzy establishment.
El_Fantastico over 3 years ago reply report
wheres episode 9 and 10 ??


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The American Way Of War HIST5021
- Academic Session: 2015-16
- School: School of Humanities
- Credits: 20
- Level: Level 5 (SCQF level 11)
- Typically Offered: Semester 2
- Available to Visiting Students: No
Short Description
This course examines changing American notions of war over time, to both educate the students about the how the power of America has developed, the role it played in many international wars, and how it has accumulated the military that it has today. The course is divided into ten sessions, each dealing with a different aspects and developments of the American military power.
10 x 2 hours
Requirements of Entry
Standard entry to Masters at College level
Excluded Courses
1 seminar presentation, to be accompanied by a 1,250 word seminar paper
1 essay of 3,000 words
Main Assessment In: April/May
Course Aims
This course aims to:
■ expose the student to different notions of American war and warfare from the Revolution to the War on Terror.
■ develop students' methodological and chronological grasp of how American ideas have changed over this time period.
■ provide skills and knowledge that would prepare the student for further graduate work of an advanced kind.
Intended Learning Outcomes of Course
By the end of this course, students will be able to:
■ Demonstrate knowledge of War Studies as a discipline, and the nature of American notions of warfare during the period from the Revolution to today.
■ Identify and evaluate how the scholarly profession has discussed American notions of war and warfare
■ Demonstrate a high degree of proficiency in the use of sources from different disciplines in seminar discussions and written work.


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James L. GoodwinFebruary 21,2013James L. Goodwin Rites
The funeral service for James L. Goodwin, 87, of Rutland, who died Feb. 15, 2013, was held Tuesday, Feb. 19, at Christ the King Church in Rutland.
Officiating was the Rev. Justin Baker, pastor.
Burial will be at a later date in Calvary Cemetery.
William Gower Johnson was the organist. Brytani Munukka was the vocalist.
The eulogy was offered by Kevin Goodwin.
Honorary bearers were Robert Carroll, Charles McGinnis, Dominic Ferraro and Floyd Van Guilder.
Bearers were Sean, Kevin and James Goodwin, and James McFarlane.
Military honors were provided by American Legion Post 31. Richard White made the flag presentation.
Prayer services were held Monday afternoon at the Clifford Funeral Home.
Memorial contributions may be made to Mount St. Joseph Academy.MORE IN ObituariesMichael Sawtell
A celebration of life for Michael Sawtell will be held at 10 a.m. Full StoryFederic D. Hoth
BENNINGTON Frederic D. Hoth, 94, of Bennington, died Sunday, Jan. Full StoryFrederick C. Rieben III
ARLINGTON Frederick C. Full Story
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Pro ASP.NET MVC 5Apress 2014; US$ 59.99
The ASP.NET MVC 5 Framework is the latest evolution of Microsoft's ASP.NET web platform. It provides a high-productivity programming model that promotes cleaner code architecture, test-driven development, and powerful extensibility, combined with all the benefits of ASP.NET. ASP.NET MVC 5 contains a number of advances over previous versions,... more...
WebRTC BlueprintsPackt Publishing 2014; US$ 25.99
This book is a step-by-step project-based guide that aims to teach you how to develop your own web applications and services with WebRTC in a concise, practical manner.If you are a WebRTC developer and want to build complex WebRTC applications and projects, or if you want to gain practical experience in developing web applications, advanced WebRTC... more...
Take Control of iCloudTidBITS 2015; US$ 15.00
Understand its features and limitations, get set up, and enjoy iCloud! iCloud is a simple idea -- all your data on all your devices, via the cloud -- that becomes complex in the real world when you want everything to work efficiently so you can spend your time enjoying your media or doing actual work, instead of just fiddling with your computer.... more...
PythonPearson Education 2013; US$ 27.99
Python is a remarkably powerful dynamic programming language used in a wide variety of situations such as Web, database access, desktop GUIs, game and software development, and network programming. Fans of Python use the phrase "batteries included" to describe the standard library, which covers everything from asynchronous processing to zip files.... more...
No B.S. Guide to Direct Response Social Media MarketingEntrepreneur Press 2015; US$ 17.99
To avoid grabbing every business owner he meets by the shoulders and shaking them, millionaire maker Dan S. Kennedy has joined with marketing strategist Kim Walsh-Phillips to help business owners, private practice professionals, and professional marketers start making dollars and cents of their social media marketing. Daring readers to stop accepting... more...
Powerful Executive CoachingAMACOM 2012; US$ 0.99
Leaders can make or break a company?which is why coaches are so crucial. Effective coaching can ensure that executives reach their peak potential and drive organizational results. Powerful Executive Coaching delivers a concise, but powerful look to how to coach current leaders and high potentials. It goes straight to the core components of successful... more...
Confluence, Tech Comm, ChocolateXML Press 2013; US$ 24.95
Web and Tech Comm guru Sarah Maddox takes you inside the Confluence wiki for an in-depth guide to developing and publishing technical documentation on a wiki. She looks at life on a wiki from the points of view of both technical writers and readers. Confluence, Tech Comm, Chocolate shows you how to make your wiki fly. While it focuses on Confluence,... more...
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Forums add a powerful component to any website. This is the only guide that shows how to run a fun, informative, and harmonious online forum. more...
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Complete summary of Dan Kennedy's book: "The Ultimate Marketing Plan: Find Your Most Promotable Competitive Edge, Turn It Into A Powerful Marketing Message And Deliver It To The Right Prospects". This summary of the ideas from Dan Kennedy's book "The Ultimate Competitive Advantage" shows that the true essence of marketing is simple: getting the... more...


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Lot 151: Ivon Hitchens , British 1893 - 1979 FLOWERS IN A BLUE JUG Oil on canvas
Important Australian Art
by Sotheby's
August 24, 2009
Melbourne, Australia
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Description: Signed Ivon (lower left) ; bears artist's name and title on gallery label on reverse; bears artist's name and title on label on reverse Oil on canvas
Waddington Galleries, London
Dr and Mrs N. Hawkins, Sydney; purchased from the above
Dimensions: 75 by 50cm
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Jay Z and Beyonce kicked off their On The Run Tour yesterday (June 25) in Miami, Florida.
The couple performed solo songs and duets throughout the evening, according to reports. Their set featured 42 songs, according to Radio.
The night also featured Beyonce filling in for Justin Timberlake on "Holy Grail" and Jay Z doing a remix of "Partition." Beyonce reportedly covered Lauryn Hill's "Ex-Factor" and paid tribute to Michael Jackson with a performance of "Love On Top."
"It was over two hours of tightly choreographed showmanship that was timed to the second," Billboard says of the show's opening night, "alternating between the pair's solo history, their collaborative hits and by duet versions of hits both have originally recorded with others."
The tour is reportedly on pace to being the second-most successful tour ever in terms of gross revenue per show.
Photographs and Instagram clips of the event are below, followed by the opening night's reported set list.
Photographs via Huffington Post.
Setlist, According To Billboard
"'03 Bonnie & Clyde"
"Show Me What You Got"
"Upgrade U"
"Crazy in Love"
"Show Me What You Got"
"Diamonds are Forever"
"N***as" in Paris"
"Tom Ford"
"Run the World"
"Jigga That N***a"
"Dirt Off Your Shoulder"
"Big Pimpin'"
"Ring the Alarm"
"On to the Next One"
"Baby Boy"
"U Don't Know"
"No Church in the Wild"
"Drunk in Love"
"Public Service Announcement"
"Why Don't You Love Me"
"Holy Grail"
"Beach Is Better"
"99 Problems"
"If I Were a Boy"
"Ex Factor" (Lauryn Hill cover)
"Song Cry"
"Love on Top"
"Izzo (H.O.V.A.)
"I Just Wanna Love U (Give it 2 Me)"
"Single Ladies"
"Hard Knock Life"
"Pretty Hurts"
"Part II (On the Run)"
"Forever Young"
"Lift Off"
For a chance to win Jay Z & Beyonce On The Run tour tickets, click here.
RELATED: Jay Z & Beyonce Preview "Run," Trailer Says It's "Coming Never"


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2 Parks near Ruffs Dale, Pennsylvania
New Stanton, Pennsylvania 5.05 miles NE
Connellsville, Pennsylvania 10 miles SE
Donegal, Pennsylvania 13.97 miles SE
Charleroi, Pennsylvania 15.63 miles SW
Mill Run, Pennsylvania 16.09 miles SE
Ruffs Dale, Pennsylvania
Sites: 60 | Latest Rate: $30.00 | 1 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2007 - $30.00
The bathhouse was closed for renovation until further notice when we camped here. Some sites are creekside (no sewer) and other full hookups were up steep, winding curves, between close trees. A little hard to navigate with a large camper but the scenery was beautiful. Owner is very friendly and the campground is gated for camper security. Owner emptied tanks on electric / water only sites twice a week at no extra charge. This campground is off the beaten path; yet close to village of New Stanton and the Westinghouse energy site. We would recommend this campground to anyone! - lapo99
Ruffs Dale, Pennsylvania (map) | (724) 722-4444
Sites: 117 | Latest Rate: $45.00 | 55 Reviews
|Clean Restrooms:
|Clean Showers:
Aug 2015 - $45.00
Sites are not level, not even close. After bending my rear jack and tripping the hydraulic breaker I moved to another site. Managed to get almost level and found the dump connection a foot up a hill from my dump outlet, would not drain. Poor cable. Shade is good and park is scenic but needs some site work. Worth about $12, not $45. - Marathon dan
Aug 2015 - $50.00
Very nice KOA. Playground, jumping pillow, fishing lake, etc. The campground is a bit hilly. The site was not level side to side, so I had to use the leveling blocks. But it was otherwise very nice. Spacious. Good picnic table and fire pit. The bath house was close by and it was clean. It was a bit rustic, but it was very suitable. We stayed there for one night on the way back from a two week trip, but we would stay here longer if we came through this way again. Its a very nice campground. The staff was incredible friendly. They had a pirates weekend, so the staff was all in costume. They had an ice cream social the night we were there, which was very nice. Good place to stay. - Brad K
Jul 2015 - $55.00
This was an overnight stay as we traveled from Ohio to Virginia. There are not many RV parks in this part of Pennsylvania, and there was no alternative based on our route. It was a little tricky to maneuver in a 40' motorhome, as the roads are quite narrow and hilly. We did not use the facilities, so I can't comment on them. The rate quoted is the KOA rate without discount. With the KOA discount it was $49.50, which still makes it overpriced. - SheilaB104


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Nolan McConnell scored a goal with three minutes left in the game against LMU to secure the win.
Sept. 16, 2012
Stanford, Calif. - Long Beach State swept a pair of games on Sunday beating UC Davis 10-9 and Loyola Marymount 9-7 to wrap up the NorCal Tournament. The 49ers finished the tournament in ninth place with a 3-1 record.
Game 1: #9 Long Beach State 10, #12 UC Davis 9
The 49ers (9-1) survived a late rally by the Aggies (5-4) in the fourth quarter to hang on for the 10-9 win. UC Davis scored four goals in the final three minutes, but could never get closer than one goal.
Dan Matulis led the 49ers with four goals and Carter Taylor chipped in two.
Balint Meszaros collected eight saves in the win.
Game 2: #9 Long Beach State 9, #10 Loyola Marymount 7
Matulis and Nolan McConnell both scored in a 30 seconds stretch to break a tie with three minutes to play and give the 49ers the win over the Lions in Sunday's late game.
Brian Schiefer, McConnell, Taylor, and Matulis each scored two for LBSU with Milos Vrzic adding one.
After the Lions (3-3) tied the score at seven, Matulis hit a straightaway shot at the 3:30 mark on a pass from Vrzic. McConnell found the back of the net with a drop shot to the left side to give the 49ers a two-goal lead.
Meszros recorded eight saves, with two coming on penalty shots in the second quarter. Meszaros finished the four-game tournament with 38 saves.
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Coach Arroyo Named 2014 MPSF Coach Of The Year11/25/2014 - M. Water Polo
Men's Water Polo ninth-year Coach Gavin Arroyo was named the 2014 MPSF Coach of the Year. This is...
Beach Men's Water Polo Finishes Second In The...11/23/2014 - M. Water Polo
Long Beach, Calif. - No.4 LBSU Men's Water Polo finished the MPSF Championship Tournament in...
No. 4 Men's Water Polo Upsets No. 1 UCLA In The...11/22/2014 - M. Water Polo
Beach Men's Water Polo took control over the Ken Lindgren Aquatics Center Saturday afternoon with...
No. 4 Men's Water Polo Opens The MPSF...11/21/2014 - M. Water Polo
Men's Water Polo came out strong in their first match of the MPSF Tournament. No. 4 Long Beach...
Men's Water Polo Hosts MPSF Tournament As...11/20/2014 - M. Water Polo
9 teams will enter but only the No. 1 winning team will grab the NCAA's automatic qualifier in...
No. 4 Men's Water Polo Loses To MPSF No.1 UCLA11/15/2014 - M. Water Polo
LBSU traveled to Westwood in their final MPSF Conference match before the playoffs, but...


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Dame Edna: Michael L. Walters' Tribute to Australian "Gigastar"
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for Michael L. Walters as Dame Edna was Sunday April 27, 2014 / 5:00pm.
Currently at Cabaret Theater at CAMP Bar
Booze-Fueled Comedy in Bye Bye Liver: The Twin Cities Drinking Play
- Full Price:
- $24.50
- Our Price:
- $12.25
Drunken friends, overserved basket cases, pushy bouncers and all the other hallmarks of bar culture… More
Venue Details
Reviews & Ratings
Featured review from Mary Jo Halverson
view more less of this review
My husband and I attended after a wonderful dinner next door at Sawadee. We weren't sure what to expect of Dame Edna, but had heard about him for many years so decided to take a chance.
It was wonderful! He's very funny, engages audience members,
and also sings during the performance. It was a fun evening. Camp is always a fun place, small, with a bar right in the room, and every time we have been there the audience has been lots of fun.
star this review starred report as inappropriate
We had good seats in this venue, so it was warm and friendly. He had an absolutely wonderful voice. Several octaves. My husband really enjoyed it. He was kind to everyone he picked on!
star this review starred report as inappropriate
Wish I had bought tickets to see the first and second show not just the first. Too funny. Singing voice was over the top. You go girl.
About the Ticket Supplier: Actors Theater of Minnesota
Actors Theater of Minnesota is a professional theater company located in the heart of Downtown Saint Paul's charming Theater District.
The Creative Institute at Actors Theater of Minnesota is committed to provide a creative educational experience in an environment of collaboration and openness.


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- El SalvadorAgricultureFunding via Apoyo Integral
Fensi GroupTanzaniaFoodFunding via Tujijenge Tanzania Ltd
Luz StellaColombiaServicesFunding via Interactuar
Ccori - Chuspa Group
Marina is a member who is 34 years old. She lives with a partner and has 4 children. She completed her studies only through secondary (high) school. She has a dressmaking workshop in her home. She set up a small space in her home where she has her sewing machine and a display cabinet showing the garments that she has made. Her partner buys and sells wood. She requests a loan to buy material for her dressmaking business such as thread and fabric. The other members are engaged in retail trade, handicrafts, taxi service, teaching, masonry, groceries and the purchase and sale of small animals.
The members appreciate and value the support provided through these means, and are committed to making their payments according to the established schedule.
Nuestra socia es la Sra. MARINA; ella tiene 34 años, la socia es conviviente, ella estudió solo en el colegio primaria y secundaria, tiene 4 hijos, Nuestra socia tiene un taller de costura en su casa, ella acondicionó un pequeño espacio para poner su máquina de coser y un exhibidor de prendas que ella misma elaboró, su conyugué compra y vende madera, La socia solicita el préstamo para comprar material de trabajo para su costurería, como hilos y telas. Nuestros otros socios comparten sus actividades con el comercio minorista, la artesanía, servicio de moto taxis, docencia, albañilería, abarrotes y compra y venta de animales menores.
Los socios agradecen y valoran el apoyo brindado mediante este medio y se comprometen a cumplir con el pago de sus deudas en el plazo establecido.
Additional Information
Important InformationAbout Asociación Arariwa
Asociación Arariwa is a large non-governmental organization that started offering microcredit in 1994 to improve the quality of life, skills and equity of the population in the rural Cusco region of Peru. Arariwa serves the southern Andean provinces of Peru, and is distinguished by its efforts to reach the very poor, who often live in isolated rural areas. Arariwa fosters village banking, supports savings accounts, promotes access to education, and empowers women entrepreneurs (who make up 78% of its borrowers).
This is a Group Loan
In a group loan, each member of the group receives an individual loan but is part of a larger group of individuals. The group is there to provide support to the members and to provide a system of peer pressure, but groups may or may not be formally bound by a group guarantee. In cases where there is a group guarantee, members of the group are responsible for paying back the loans of their fellow group members in the case of delinquency or default.
Kiva's Field Partners typically feature one borrower from a group. The loan description, sector, and other attributes for a group loan profile are determined by the featured borrower's loan. The other members of the group are not required to use their loans for the same purpose.
About Peru
45View loans »
Success!! The loan was 100% repaid
- Repayment Term
- 8 months (Additional Information)
- Repayment Schedule
- Monthly
- Pre-Disbursed:
- May 11, 2010
- Listed
- Jun 4, 2010
- Currency Exchange Loss:
- Covered
- Ended:
- Dec 15, 2010


text: Whenever I am trying to play any race in multiplayer mode online in Ridge Racer Unbounded, I find that number of people trying to join the race is very low. Sometimes I find only one or two people even after having quick search enabled. Has the interest of people who want to play this game decreased? Also many times I have noticed that people who join the race suddenly quit the race in between to leave me alone in the map. I can complete the online challenges without any problem but I cannot play with multiple players. Does anybody else too experience similar problem?


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Carrying your laptop, tablet, power chargers, smartphone and other accessories shouldn't be a burden. Our laptop carrying cases are designed to fit your laptop and everything that goes with it. Even more important, they're designed to fit you, for comfort whether you're simply heading into the office or flying off on a business trip.
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Appointments & Offices
Check insurance plans, locations and make an appointment
Is Dr. Verrette accepting new patients?
If you are a new patient, please check with Dr. Verrette before scheduling an appointment.
What insurance does she accept?*Less
Office Locations
- Pasadena Childrens Medical Grp
- 1145 E Green St
- Pasadena, CA 91106
- (626) 796-9913 (Office)


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At Dillard's, we implemented a security program to ensure that a human is trying to enter our site and not a computer. If you have any questions, please contact firstname.lastname@example.com.
If you want to pay your bill, please visit Dillards.com/payonline.
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Peek-a-Boo Sock Monkey really Socked it to 'em!!!
By Youthful Grandma
from Foley, Al
See all my reviews
Comments about Baby Starters Sock Monkey Peek-a-Boo Toy:
Purchased for a baby shower & used it as the topper on the diaper cake I made! It was a smash hit! None of the guests, nor the parents-to-be, could resist squeezing his foot whenever they passed by! I also purchased the sock monkey sock/booties and used them on the three tiers of the diaper cake! I was thrilled with this purchase! It was very reasonably priced and I'm sure will bring many smiles & lots of giggles to the new baby as well as Mommy & Daddy!
Bottom Line Yes, I would recommend this to a friend
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Recent Meetups
Nov 6, 2014 · 7:00 PMLocal SEO for Businesses (+ networking)
Join us for an exciting presentation by Chris Vendilli from ProFromGo Internet Marketing. He will discuss Local SEO: How to Increase Online Visibility in Local Markets -... Learn more
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Startups, nonprofits, and businesses of all sizes are squarely focused on mobile and social strategies as a way to attract and engage with their target audiences. But... Learn more
Jul 18, 2013 · 6:00 PMSocial Media and Shark Bait (Plus: Networking & Yummy Food!)
Mike Kane from cellhelmet will discuss what he's learned about using social media for promotion and the importance of developing relationships online. He'll also talk... Learn more
May 16, 2013 · 6:00 PMInternet Marketing Meetup & Happy Hour
Drink beer. Eat pizza. Get together with your favorite Internet marketers to discuss everything you love (and hate) about SEO, PPC, and Social Media.
Dec 13, 2012 · 6:00 PMAnalytics and SEO with LunaMetrics!!
Hey y'all!! LunaMetrics has offered to host our SEO meetup group on the 13th of December! Jim Gianoglio will be presenting on how to effectively measure SEO efficacy... Learn more
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These majestically designed gold coins contain an ounce of fine gold. Designer Philip Nathan has outdone himself depicting a lovely windblown personification of Britannia. NGC has certified this coin as a Proof-69 issue, with the further designation of Ultra Cameo.
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We provide all of our customers with a refund, return and / or exchange on everything we sell including all bullion and certified coins. If for any reason, you have a problem, please feel free to call us. We will always do our best to accommodate you.