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Energy and Environment Program
Energy and Environment Program
Energy Policy Forum
The 2015 Energy Policy Forum, "Leaning Into the Energy System of the Future," was co-chaired by Sue Tierney, Managing Principal of The Analysis Group and former Assistant Secretary of Energy for Policy, and Clint Vince, Chair of the U.S. Energy Practice at Dentons U.S. LLP. Topics discussed included new global energy pricing realities and the effects on domestic energy; the Clean Power Plan; the electricity source mix of the future; and new business models needed to deal with current markets realities.
Major takeaways from the discussion at the 2015 Energy Policy Forum included the following:
- The extraordinary supply boom in the U.S. from the shale revolution and the decision of OPEC not to cut production combined with flattening consumption in BRIC countries have had profound global implications for energy prices, electricity trends and emissions.
- The energy system of the future will see greater convergence between different parts of the market – between energy policy and environmental policy, energy networks and other systems, electricity and gas, and state-regulated distributed resources and central station wholesale and interstate resources.
- U.S. electricity demand is mostly flat, which means investments in new generation are ultimately about displacement and cannibalization, driven in part by environmental and renewable energy targets and policies.
- Technology and the focus on the user experience are increasingly eroding the incumbent utility business model, raising the question of how fast the core will shrink and whether the model can react with sufficient agility.
- The U.S. is in danger of losing its position of leadership and influence in nuclear energy and has a strategic choice to make: either design new policy tools or cede the market to China and Russia.
For more, Download the 2015 Report.
About the Forum
For 40 years the Aspen Institute Energy and Environment Program has convened a select group of leaders by invitation from business, policy, academia, and non-profit organizations to discuss a range of current and emerging energy policy issues. The format relies heavily on dialogue among experts with varied perspectives and expertise. A few brief discussion-starting presentations begin each session, with the majority of the time reserved for dialogue among the 70 or so participants.
|The 2014 Forum, "Responding to Trends in the U.S. Electricity Sector," was chaired by Sue Tierney, Managing Principal of The Analysis Group and former Assistant Secretary of Energy for Policy. Topics discussed included EPA's recently proposed rules on CO2 emissions from existing power plants, fuel choices, distributed energy sources, and models for providing energy services. Download.
|"The Future of the U.S. Electricity Sector" was the focus of the July 2013 Energy Policy Forum chaired by Bill Dickenson, Energy Practice Leader at Navigant, and Phil Sharp, President of Resources for the Future and former Chair of the House Energy and Power Subcommittee. The group examined visions for the future, potential game changers, lessons from China, and resilience and cybersecurity. Download.
|The 2012 Forum, "Electricity: Seeking Progress amid Uncertainty," was chaired by Ernest J. Moniz, Professor of Physics and Engineering Systems, and Director of the Energy Initiative at MIT. Topics included regulatory issues affecting the financial model of utilities, the obstacles to the moves toward greater energy efficiency, the challenge of meeting energy and water needs simultaneously, factors affecting utility choices between coal and gas, and the challenges of financing new development. Download.
|"Changing Currents: Turbulence for the Electricity Industry?" was the focus of the 35th annual Forum in July 2011. Topics included options to mitigate climate change, aging infrastructure, electric vehicles, renewable energy, the future of nuclear power in the wake of the Fukushima disaster, and lessons from China. Phil Sharp, President of Resources for the Future and former Chair of the House of Representatives energy subcommittee, chaired the Forum. Download.
|The 2010 Forum considered a range of challenges to "Providing Energy Services in a Changing World." The invited industry leaders and experts discussed different visions for the future, obstacles to achieving these visions, examples of transformational change in other industries, the impact of possible climate change legislation, and the challenges and opportunities for various primary energy sources. The Forum was chaired by James E. Rogers, Chairman and CEO of Duke Energy. Download.
The 33rd annual Forum in July 2009 examined the electricity transmission grid in the US, the need for enhancements to improve reliability and allow the use of remote sources of renewable energy, the financial and siting challenges of building new transmission, the question of who pays, the potential and challenges of electric cars, and the opportunities provided to customers and utilities by new "smart grid" technologies. Linda Stuntz, former Deputy Secretary of Energy, and Susan Tomasky, Executive Vice President of American Electric Power, co-chaired the Forum. Download.
With the expectation that a new Administration and Congress in 2009 would actively consider climate change legislation, the 2008 Forum considered "Climate Change and the Electricity Sector." Chaired by Jonathan Lash, President of World Resources Institute, and Jeff Sterba, CEO of PNM Resources, the Forum explored the science of climate change and the economic challenges of mitigation, heard from a panel of utility CEOs, considered several policy choices, and discussed new and evolving carbon markets. Download.
The 2007 Forum, "Energy: Old Challenges, New Opportunities," focused on energy decisions facing the United States, including vulnerabilities caused by increasing oil and gas imports, how to reduce emissions of greenhouse gases, and the move toward greater competition in electricity markets. Under the chairmanship of Walter M. Higgins, CEO of Sierra Pacific Resources, and William W. Hogan, Professor of Public Policy & Administration at Harvard University's Kennedy School of Government, the group also explored solutions including demand reduction, nuclear power, renewable fuels, carbon capture and storage, and improved auto fuel efficiency. Download Contents, Conclusions, Agenda and Participants; Vulnerability and Liquid Fuel Demand; Demand Reduction in Buildings; Reducing Carbon Emissions from Electricity Generation;Governance of Electricity Markets.
"Energy: The New Normal?" was the theme of the 2006 Forum, chaired by Phil Sharp, President of Resources for the Future and former Chair of the U.S. House Energy and Power Subcommittee The Forum explored from various perspectives whether high energy prices, increased fighting in the Mideast, and a growing acceptance of the need to act on global climate change has changed the energy world. The forum specifically examined drivers of policy such as energy supply and demand, climate change, and geopolitics; the R&D and financing challenges of new technologies; and how various fuels are likely to fare as utilities make decisions on new generating capacity. Download.
The 2005 Forum, chaired by Cinergy Corp. Chairman and CEO James E. Rogers, considered who will build needed new power generation and transmission facilities in light of a hybrid regulatory structure, industry reorganization, financing uncertainties, and concerns about fuel availability and regulation of carbon emissions. The Forum report, "Electricity: Who Will Build New Capacity?", is organized around recommendations on market design, energy efficiency, innovation and technology choice, carbon management, and infrastructure security. Download.
|In 2004 the Forum topic was "Fossil Fuels, the Hydrogen Economy, and Policy Choices". Chaired by Red Cavaney and Susan Tomasky, the forum considered variables affecting each of the fossil fuels, domestically and globally, including new technologies and the competition offered by alternatives such as renewables and nuclear. It also examined the problems and potential of hydrogen, including its primary fuel source, and considered recommendations for near-term government energy policy. Download.
|In 2003 the Forum focused on "Electricity Restructuring". Chaired by former Director of Central Intelligence and Undersecretary of Energy John Deutch, participants discussed the advantages and disadvantages of national rules governing transmission, economic and market power issues affecting ownership, whether the markets choice of fuel is in the national interest, whether natural gas supplies are adequate, and how restructuring will affect the future of nuclear power, renewables, efficiency, and distributed generation. A series of Electricity Recommendations were sent to Congressional and Administration leaders following the Forum. Download.
|The 2002 Forum took as its theme "Vulnerability and Resilience," reflecting the concerns about various forms of security following terrorist attacks, anxiety about Mideast oil supplies, worries about the sustainability of energy systems, and uncertainty about the restructuring of the electricity industry. Former Senate Energy Committee Chairman J. Bennett Johnston chaired the Forum. Download.
In 2001, in the wake of a year of energy price volatility, serious electricity supply and price problems in California, and new proposals for energy legislation, the 25th annual Forum examined "Energy Supply and Infrastructure." Former Energy and Defense Secretary James R. Schlesinger chaired the Forum, which included sessions on natural gas supply, the California electricity crisis, the future of electricity restructuring elsewhere, and domestic and world oil markets. Download.
In 2000, the 24th annual Forum, "Market, Technology, and Policy Drivers: The Future Structure of the Electricity Industry," considered external factors that are driving the reconfiguration of electric utilities and the growth of new companies. Co-Chaired by former Presidential Science and Technology Advisor John H. Gibbons and Harvard Public Policy Professor William W. Hogan, the Forum explored e-commerce, generation and transmission technologies, investment and financial considerations, and legislative and regulatory factors. Download.
The 1999 Forum, "Fuel Choice, Supply and Reliability in the 21st Century," was co-chaired by Secretary Schlesinger and Edison International CEO John E. Bryson. Responding to continuing interest in the rapidly restructuring utility industries and to the low prices and merger activities in the oil industry, the Forum examined how these trends might play out in coming years. Download.
The 1998 Forum, "After Kyoto: Are There Rational Pathways to a Sustainable Global Energy System?", was chaired by AES Corporation and World Wildlife Fund Chairman Roger W. Sant. It addressed a number of major energy questions and challenges surrounding the Kyoto Protocol and the broader issue of how to achieve a sustainable global energy system. Although participants disagreed on the adequacy of the scientific basis for strong early actions to reduce greenhouse gases and on the wisdom of the Kyoto Protocol, there was widespread agreement on the need to take a long-term approach, to accelerate research and development in low-carbon and non-carbon fuels and technologies, to remove barriers to technological innovation, and to depoliticize the climate change debate. An open letter from several Forum participants transmitted these and other conclusions to the President and to Congressional leaders.
All past reports are available online and can be downloaded, and are also available in print from the Institute's Publications Office.


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How to Trick Your Parents Into Thinking That You're Sleeping
In order to be able to sneak out of the house, with your parent checking in on you and finding out your not there, you are going to need to know how to make it look like you are still there.
This article has been tagged as a stub.
That means it's off to a good start, but still has room to grow into a more helpful resource. Until the article reaches its full potential, it will be hidden from search results. Can you help it flourish? If you think the article offers complete and accurate instructions, feel free to remove this tag.
1Take a pillow and buy a wig to put on it. If you can't get a wig, then take some string about the color of your hair and sew the "hair" onto it.
2Put some pillows in your bed so it looks like you're just relaxed. The best position is with your legs bent slightly and so it looks like you are on your side.
3Leave a small note on the body just in case your parents find out that you did escape, and make sure that you take your cell phone with you so they can call you.
4Put some thick sheets over "your" body and make sure your parents don't see those fake bodies before you are out of the house!
Community Q&A
Ask a Question
- Don't leave your house until it is pitch black outside, that way they can't tell so easily that you aren't the one in the bed.
- If you can get a hold of a tan, or flesh color pillowcase, then make sure you use that, or you can paint it. *If your mom reads the note be sure to tell her you aren't out drinking and not to worry too much.
- Results may vary due to exactly how much your parents trust you.
- Make sure that if you paint you pillow case that your parents don't see it cause they will wonder why there is flesh colored paint on it!
Things You'll Need
- Pillows(about 3-4 per person)
- Yarn or wig
- Paint if needed(cover up works good too since it washes out.
- Covers, blankets
Article Info
Categories: Stub | Making Excuses
Thanks to all authors for creating a page that has been read 16,631 times.
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MMA Forum - UFC Forums - UFC Results - MMA Videos (http://www.mmaforum.com/forumindex.php)
- Previous Sports Wagers (http://www.mmaforum.com/previous-sports-wagers/)
- - NFL: Dallas vs Atlanta (http://www.mmaforum.com/previous-sports-wagers/106494-nfl-dallas-vs-atlanta.html)
NFL: Dallas vs Atlanta
Atlanta stays undefeated IMO. Dallas is very up and down and Atlantas offense is very very good.
They stayed undefeated, 19 to 13.
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Extra Emollient Night Cream is basically Vaseline and mineral oil along with several waxes. Yes, it will make dry skin feel smooth and lubricated, but the inclusion of menthol is a burn.
(based on 8 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Reviewed by 8 customers
Displaying reviews 1-8
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great stuff
By g
from casper wy
About Me Budget Buyer
Comments about Mary Kay Extra Emollient Night Cream:
not usually much of a brand buyer, but this product works on dry chapped feet better than any foot care product or vasoline I've tried
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Horrible smell
By T
from Ft. Wayne, In
This product has an absolutely obnoxious smell!! Very old fashioned floral. Smells like a scented candle! Gross! Needs a fresh clean scent.
Bottom Line No, I would not recommend this to a friend
Cracked feet no more
By Chapped lips and working hands
from Los Angeles
About Me Brand Buyer
My feet used to be really bad. I throw this on before bed and let it soak in at night. My feet are no longer cracked and they stay nice and soft.
(1 of 1 customers found this review helpful)
Great for everything
By Elle
from Arizona
I have had this product around for at least 30 years. It is the best for dry skin and burns and cuts. My grandchildren were just visiting me in Arizona and they had diaper rash that would normally take several days to get better and I put this project on them and it was all better the next day. Their mother and father could not believe it. I've used it on cuts and burns and it is amazing. I used to sell Mary Kay 30 years ago and everyone loved this product. I was told that it was used for for burn victims. I hope they never get rid of it. I believe this was Mary Kay's first project.
(4 of 4 customers found this review helpful)
old faithful
By L S
from undisclosed
I have used this since 1986. It was discontinued briefly, and demand brought it back. I know from the ingredient list it is mostly petroleum and mineral oil but I have yet to find a replacement product that works so well for me. You use very little, it lasts for ages,no added water. It takes about 10 minutes to fully absorb. I use it in the winter months at night face to toe! I use it during the winter days when outside. No chapped skin on face or hands for me. You either love it or hate it.
(5 of 5 customers found this review helpful)
Wonderful products! Review is Hogwash!
By Nic S
Honestly I cannot understand the review of this product and Mary Kay products in general. They're brilliant products - especially if you've got oily and blemish prone skin! I've not had any problems at all in the 7+ years I've used them. No exfoliators? What planet are you on? The 3-in-1 Cleanser, Toner & Exfoliator is fab! No need for 3 products when 1 does the trick. Outdated? Maybe they don't change their products as often as other brands, but that's a good thing at least I know what to buy!
(2 of 2 customers found this review helpful)
In love with this product!!
By lacee m
I would recommend this to everyone!! The very first night I used it I woke up with a smooth flake free face. My wrinkles around my eyes were softened considerably as well. I have combination skin and this product is greasy when u first put it on but it doesn't matter bc you use it at night. It doesn't tingle or burn at all. It makes my feet & hands amazingly soft. I will forever use this product! I remember my mom using it when I was younger too so it has been around awhile.
Extra Emollient Night Cream
By Laurie E
This is a wonderful product!!! It feels greasy when you first put it on but once absorbed it leaves skin feeling wonderfully soft. I love it for my face, neck, hands and feet. It is especially wonderful for hands and feet when used with the satin hands products! Love it!!! Is also a wonderful diaper cream :-)
For extremely dry skin. Helps maintain the natural moisture of the face and replenishes hydration in especially dry areas such as hands, elbows and feet.
Petrolatum, Mineral Oil, Paraffin, Beeswax, Candelilla Wax, Hydrogenated Soy Glyceride, Fragrance, Carnauba Wax, Stearic Acid, Propylparaben, Butylparaben, Menthol, Red 17
Mary Kay At-A-Glance
Strengths: Most of the products are fragrance-free; packaging that keeps light- and air-sensitive ingredients stable during use; a handful of well-formulated moisturizers; very good eye-makeup remover; effective wrinkle filler; excellent cream blush and several other impressive makeup products.
Weaknesses: The overall collection is a mixed bag of exciting and disappointing products; several outdated moisturizers and cleansers; no AHA or acceptable BHA products; the CC Cream doesn't provide good enough UVA protection; some lackluster makeup products.
The last few years haven't been glamorous for one of the world's largest direct sellers of cosmetics. Mary Kay lost a lawsuit filed by TriStrata, the company whose founders hold over 100 patents on the use of AHAs in skin-care products. It was revealed that Mary Kay's former AHA products infringed on three of these patents, and, after some back-and-forths in court, Mary Kay ended up paying royalties of over $40 million (interest included) to TriStrata. Perhaps because they're still licking their wounds after this defeat, the company has not launched any new AHA products, and no longer sells the ones that were in question during the legal battle (Source: www.bizjournals.com/dallas/stories/2006/04/03/daily26.html).
However, the company's spin on the issue of AHAs is that they no longer use them because skin-care technology has advanced. That's an interesting twist, but the fact of the matter is that AHA products, when well-formulated, are still considered advanced and capable of doing far more for skin than the alternatives Mary Kay has devised (including an at-home microdermabrasion scrub and products with vitamin C derivatives).
Although they're not a company for you if you are looking for exfoliants (though you should be looking for a good exfoliant), Mary Kay has recently developed a surprising number of excellent products. With over 1.6 million Mary Kay consultants selling products in 30 countries, this family-owned company (founder Mary Kay Ash passed away in 2001) has slowly been proving that they intend to remain competitive with the best of the best. A refreshing change of pace is the omission of fragrance from almost all of the products. Now that is what we call progress!
Despite its size and capital (wholesale figures were $3 billion in 2012), Mary Kay still has a lot to learn. For instance, although their guiding philosophy of empowering women is admirable, the assortment of products still leaves much to be desired. Yes, things are looking up, but there are several weak spots that keep Mary Kay from being in the same league as Avon, Estee Lauder, Procter & Gamble (Olay), and Johnson & Johnson (Neutrogena, Aveeno, RoC). These include outdated cleansers, toners, and moisturizers, along with letdowns in products designed for oily, blemish-prone skin. The TimeWise product range has expanded considerably, and offers a few state-of-the-art products worthy of its name (although, as with all skin-care products, they're not going to turn back the hands of time and erase all signs of aging).
If improvements like those in Mary Kay's latest products were translated to the entire line, it would be standing much taller, at least as far as what current, substantiated skin-care research indicates is optimum for creating and maintaining healthy skin. As is, this is a line to approach with a keen understanding of what to focus on and what to avoid. One last bit of good news: Mary Kay offers well-packaged samples of selected products, either directly or from your consultant.
Unless mentioned otherwise, all Mary Kay products are fragrance-free.
Note: Mary Kay is categorized as a brand that tests on animals because their products are sold in China. Although Mary Kay does not conduct animal testing for their products sold elsewhere, the Chinese government requires imported cosmetics be tested on animals, so foreign companies retailing there must comply. This requirement is why some brand's state that they don't test on animals "unless required by law". Animal rights organizations consider cosmetic companies retailed in China to be brands that test on animals, and so does the Paula's Choice Research Team.
For more information about Mary Kay, call (800) 627-9529 or visit www.marykay.com.
The new Beautypedia Team proudly and unequivocally maintains the commitment to help you find the best products possible for your skin. We do this by relentlessly pursuing and relying on published scientific research so you will have unbiased information on what works and what doesn't-and the sneaky ways you could be making your skin worse, not better!
The Beautypedia Team reviews all products using the same research, criteria, and objectivity, whether the product being reviewed is from Paula's Choice or another brand.
Thanks for sharing your experience with this product! Approved reviews appear on our site within 3-5 business days.
We reserve the right to reject or modify reviews without notice. All submitted reviews become the property of Paula's Choice, LLC.
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Paula's Choice Auto Delivery is a quick and convenient way to make sure you never run out of your favorite products again. Just select the products you can't live without, choose how often you'd like them delivered and we'll take care of the rest.
*No promo code required; discount automatically applied in cart to original retail value of eligible full-size items. Eligible items include products featured on the AHA & BHA Exfoliants page. Offer cannot be applied to previous purchases or combined with other discounts. Applies to in-stock items only; no rain checks. Offer expires 9pm PT, May 31, 2016. Paula's Choice reserves the right to modify this offer at any time.
**Promotion expires 9pm PT, May 31, 2016. No cash value. Applies to US and Canada only.
***Promotion expires 9pm PT, May 31, 2016. Choose any 3 from 34 available FREE individual sample packettes on orders of $5+.
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(21 reviews)
|product name: SUISSE PROGRAMME PLATINUM
Refining Milk Cleanser (200ml)
|item no.: 100773503001
|brand: SUISSE PROGRAMME
|ative from: 2005-01-23 00:00:00
|product size: 200 ml
|function: Hydrating Anti-wrinkleNourishingOil ControlBrighteningPeelingAnti-oxidizingFirmingDeep Cleansing
|category: Cleansing Milk
A soothing, ultra rich milk cleanser that effectively removes make-up and impurities. It gently exfoliates the skin surface while stimulating cell-restructing.
Morning and evening, moisten the fingertips and apply with small circular movements to face. Tissue off and remove remaining residue with lukewarm water or a cotton pad moistened with Revitalizing Tonic Lotion.
all skin type


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Interim Primary Headteacher
- Recruiter
- Location
- South East England
- Salary
- £450 - £500 per day
- Posted
- 24 Oct 2013
- Closes
- 21 Nov 2013
- Ref
- Contact
- Jennifer Nash
- Industry
- Schools, Secondary Leadership, Head teacher & Principal
- Job Level
- Management
- Hours
- Full Time
- Contract
- Temp
- Listing Type
- Job vacancy
- Education Level
- Postgraduate degree (Masters or higher)
Interim Headteacher
January 2014
Competitive daily rateThe job… We are currently looking for an inspirational and experienced primary Headteacher for an interim assignment to start in January 2014. From a primary background you will have previous experience as a substantive Headteacher. From a Primary School background, you will have previous substantive experience as a Headteacher. A direct communicator and effective coach, you will have the ability to mentor and performance manage staff to deliver outstanding results.The school, the child…
The primary school is one form entry and is based in a rural location in the South East. It provides a good standard of education for it's pupils and has a range of awards for sport and healthy living. The school is well supported by governors and parents and there has been an upward trend in attainment. The school continues to grow and is also oversubscribed. Behaviour is outstanding and attendance is high, the pupils are commited to their learning.If you possess the skills and experience relevant for this role please apply. In reward for our candidate's hard work and commitment we provide competitive rates of pay with no hidden deductions, a refer a friend scheme, long-term and permanent job opportunities, a dedicated consultant and an honest and trustworthy approach that matches you to the right school.All candidates will be subject to Randstad Education's child safety standards and UK eligibility checks.


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Housing Act
Home Report
Shared Ownership
Homes Fit for the 21st Century sets out the Scottish Government's vision for housing to 2020 and actions and proposals to realise that vision.
With a focus on strategic objectives to promote effective supply, choice and quality, the paper recognises that radical and innovative measures are required to change the way we invest and make use of existing housing, the way we think about housing and the way we support people in their housing choices.
We have produced an update report showing progress against the outcomes referred to in Homes Fit for the 21st Century. We are working with our stakeholders to take forward our housing strategy priorities.
Page updated: Monday, May 09, 2016


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The Art of Growing Old Disgracefully
I want to celebrate my birthday in the manner I've always celebrated by birthdays. Dancing in a nightclub until I can't feel my feet for two days. I know. I'm 'supposed' to have grown out of that aren't I? So that's the rub: Act young and you might get thought tragic. Act older and it's - well - it's boring.


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When Harry Met Sally Live! -- A Staged Reading of the Classic Rom-Com
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for When Harry Met Sally Live! was Saturday March 8, 2014 / 7:30pm.
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Comedian Arj Barker (Flight of the Conchords, The Marijuana-Logues)
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What a fun, lively evening out! The four leads were exceptional, the time flew by! Liked the small intimate setting. Must get on the mailing list for this theater group.
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Very well done!!!
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the venue was sketchy, but the reading was delightful!
About the Ticket Supplier: Local Jewell Productions
Founded in 2010, Local Jewell Productions brings together individuals from different artistic backgrounds to create work that represents the true essence of the art of theatre. At the helm is Christopher Jewell, a dedicated Seattle-based artist who recently made his lifelong dream of opening his own theatre a reality. Local Jewell Productions is dedicated to partnering with the Seattle community to bring powerful, touching, and often hilarious works to the stage, without the "flash in the pan" panache we have grown weary of in many modern productions.


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Original Research Article
Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction
Version of Record online: 24 OCT 2011
DOI: 10.1002/jcp.22738
Copyright © 2011 Wiley Periodicals, Inc.
Journal of Cellular Physiology
Volume 227, Issue 1, pages 313–327, January 2012
Additional Information
How to Cite
Giri, S., Acikgöz, A., Pathak, P., Gutschker, S., Kürsten, A., Nieber, K. and Bader, A. (2012), Three dimensional cultures of rat liver cells using a natural self-assembling nanoscaffold in a clinically relevant bioreactor for bioartificial liver construction. J. Cell. Physiol., 227: 313–327. doi: 10.1002/jcp.22738
Publication History
- Issue online: 24 OCT 2011
- Version of Record online: 24 OCT 2011
- Accepted manuscript online: 24 MAR 2011 09:56AM EST
- Manuscript Accepted: 14 MAR 2011
- Manuscript Received: 30 DEC 2010
Funded by
- Medicine Faculty of University of Leipzig
- Abstract
- Article
- References
- Cited By
Till date, no bioartificial liver (BAL) procedure has obtained FDA approval or widespread clinical acceptance, mainly because of multifactorial limitations such as the use of microscale or undefined biomaterials, indirect and lower oxygenation levels in liver cells, short-term undesirable functions, and a lack of 3D interaction of growth factor/cytokine signaling in liver cells. To overcome preclinical limitations, primary rat liver cells were cultured on a naturally self-assembling peptide nanoscaffold (SAPN) in a clinically relevant bioreactor for up to 35 days, under 3D interaction with suitable growth factors and cytokine signaling agents, alone or combination (e.g., Group I: EPO, Group II: Activin A, Group III: IL-6, Group IV: BMP-4, Group V: BMP4 + EPO, Group VI: EPO + IL-6, Group VII: BMP4 + IL-6, Group VIII: Activin A + EPO, Group IX: IL-6 + Activin A, Group X: Activin A + BMP4, Group XI: EPO + Activin A + BMP-4 + IL-6 + HGF, and Group XII: Control). Major liver specific functions such as albumin secretion, urea metabolism, ammonia detoxification, phase contrast microscopy, immunofluorescence of liver specific markers (Albumin and CYP3A1), mitochondrial status, glutamic oxaloacetic transaminase (GOT) activity, glutamic pyruvic transaminase (GPT) activity, and cell membrane stability by the lactate dehydrogenase (LDH) test were also examined and compared with the control over time. In addition, we examined the drug biotransformation potential of a diazepam drug in a two-compartment model (cell matrix phase and supernatant), which is clinically important. This present study demonstrates an optimized 3D signaling/scaffolding in a preclinical BAL model, as well as preclinical drug screening for better drug development. J. Cell. Physiol. 227: 313–327, 2012. © 2011 Wiley Periodicals, Inc.


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Things to see and do - Loches
Leaving for France
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1 Donjon de Loches
Architecture, castles and historic districts
7 mail du Donjon F - 37600 Loches
The keep was built in the 11C by Fulk Nerra to defend the fortified town from the vulnerable south side. It is a solid square construction with two towers, the Ronde and the Martelet. Inside the keep, the floors of the three storeys have vanished, bu..
2 Loches Royal City
Architecture, castles and historic districts
F - 37600 Loches
The natural defensive site of Loches has been exploited since at least the 6C. The counts of Anjou and Henry II of England strengthened its defences, prior to King Louis IX transforming it into a royal residence in 1249. A number of imposing medieval..


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Welcome to Peter May
Peter May is a small innovative Ashburton company specialising in the custom design & manufacture of high quality Canvas, PVC & protective products for customers & commercial clients throughout the South Island. Our highly skilled forward thinking team, are passionate about every new and existing project they undertake.
Whether it's a stylish sail shade or shade structure, agricultural cover, protective seat cover or marine & automotive cover & repairs, call Peter & Toni May today. A prompt complimentary meeting & design is all part of our service.
If you're planning a party, marquee wedding or are attending a trade event, Peter May Marquee & Event Hire's stunning dedicated showroom at 151 Alford Forest Road is a must see. From stunning marquees with silk linings and timber dance floor to cutlery, glasses and even luxury restrooms, call in & see Toni today.
Latest News
What a big weekend! We had so much fun with it all, getting to show all of our new products and some of our future products too. Seeing all the brides there that are so excited about their big day we can't help but get excited too. It was great to show people the palate seating that we only bought in last season. View More PhotosRead more...


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Changing The Election: Social Media Voting
So what would happen if we could not only vote for our favorite candidate, but vote the ones we don't like down? That notion hit me on the way to work. I Uttered. Interested in your take.[tags]social media, election, 2008 election, presidential election, vote[/tags]


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: Ruby hack:
[Hack of the Year 2012] POKéMON LIGHT PLATINUM
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October 25th, 2012 (4:52 PM).
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Okay I ran into a problem. I'm underwater where you are suppose to dive to get to the ELITE 4 and everything looks all foggy with clouds and I can't see anything. I have no idea where I'm going. Any solutions?
Oh. There is a non-translated part. If you don't have dive and you try to dive, it will say something in Portuguese.
*Pokemon Rising Phoenix*
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"Dawn of the Planet of the Apes"
Twentieth Century Fox
2 hours, 10 minutes
"Earth to Echo"
Relativity Media
1 hour, 29 minutes
I am currently writing from the mountains of rural Vermont, and all the power has suddenly gone out, the result of yet another wild summer storm. How it can be 85 degrees out and be raining cats and dogs is beyond me, but I guess that's the East Coast for you. We're on an extended trip to the Green Mountain State while my wife goes back to graduate school, and we're all learning the ins and outs of a new place.
Aldamisa Entertainment
1 hour, 54 minutes
One of the incongruous facts about Hollywood is that more money does not necessarily mean higher quality. In fact, much of the time it seems as though big budget blockbuster directors, such as this week's Jon Favreau, often find the most success, at least in an aesthetic sense, when they are constrained by a small budget and a necessarily more intimate story to tell.
"22 Jump Street"
Columbia Pictures
1 hour, 52 minutes
Comic actor Nick Offerman sums up the concept of "22 Jump Street" perfectly in one of the first scenes of the film: "When the 'Jump Street' reboot was first proposed, everyone, myself included, expected it to be a huge failure. Much to the surprise of all, it was a hit, and now the department wants to do it again, just with much more money."
"How to Train Your Dragon 2"
DreamWorks Animation
1 hour, 42 minutes
"The Fault in Our Stars"
Temple Hill Entertainment
2 hours, 6 minutes
"Edge of Tomorrow"
Warner Bros.
1 hour, 53 minutes
As much as I enjoy Tom Cruise's movies, I've been a little dubious of his latest, "Edge of Tomorrow," for several reasons.
One, the initial trailer, though later versions have improved, wasn't much to write home about. The bulky, robotic suit/weapon worn by the soldiers in their terrifying battle with aliens just looked too cumbersome to be interesting and, aside from a creepy cool pop song, just didn't grab me.
June 3, 2014
97 minutes
Walt Disney Pictures
"X-Men: Days of Future Past."
20th Century Fox
1 hour, 44 minutes
2 hours, 3 minutes
Godzilla, as a character, has been around a long time. The original Japanese film, "Gojira" was first released in 1954 and since then there have been more than 60 different iterations.
Universal Pictures
1 hour, 36 minutes
There's a passage in the Bible that, and I'm paraphrasing here, that tells us to put away childish things about the time we grow up.
Peninsula Clarion ©2016. All Rights Reserved.


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Thursday, September 05, 2013
14 Comments | Copyright: IANS
One hot villain, and uber stylish bikes have been synonymous with Bollywood's popular "Dhoom" franchise -- and if the teaser of "Dhoom 3" is anything to go by, Aamir Khan, who plays the baddie, will take the series forward with full speed.
Aamir showcases his chiselled body in full glory, and he vrooms away on the bike, performing daredevil stunts with what seems like the ease of a professional biker.
Unlike the previous two movies, which starred John Abraham and Hrithik Roshan as the bad guys, "Dhoom 3" has gone international with a larger plot.
If the buzz for the third instalment of the Yash Raj Films' project was not enough already, the teaser, which was released online Wednesday, managed to build up more anticipation in the audiences' mind.
The teaser got uploaded on YouTube Sep 4 and has since then got over 150,000 views.
In response to the teaser on YouTube, messages like "Aamir is back" and "Aamir power rules" poured in.
One viewer posted, "Awesome movie! I will be watching this movie on first show", while a certain Rahul Bhardwaj posted: "This biker will beat the 'Express'."
We will have to wait until Dec 20 to see whether "Dhoom 3" manages to surpass the success of Shah Rukh Khan's "Chennai Express".
The teaser opens with the sound of a bike's vrooming, and the camera then zooms in to show Aamir's muscle power. He gives a poignant voiceover, and then begins the chase.
Abhishek Bachchan as supercop Jai Dixit is seen at his adventurous best suspended from a helicopter, while Uday Chopra as his right hand Ali, zips and zooms on his hi-tech bikes as usual.
Katrina Kaif adds the girl and glamour power -- and, boy, she looks athletic!
Overall, the stunts in the Vijay Krishna Acharya-directed movie look well executed -- especially that one shot where Aamir carefully skids his bike under a truck. A great escape indeed.
The past instalments have bagged hit status at the box office. Let's hope this one creates as much 'dhoom'.
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Designer Safety Knob, LLC
|Designer Safety Knob, LLC Patent applications
|Patent application number
|KNOB WITH LOCK MECHANISM - A control knob has a body and a lock mechanism. The lock mechanism acts as a safety mechanism or safeguard by biasing the knob in a locked position, thereby preventing the knob from engaging a control stem or other structure on, for example, an appliance. This prevents the knob from inadvertent rotation which may power-on an appliance, or cause a change in a current setting of an appliance which, in certain instances, may have dangerous repercussions.


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Captain America, Falcon team up in Essential Captain America vol. 3
Four different writers take the helm during the run represented in "Essential Captain America, Volume 3." The book reprints "Captain America" issues #127-56, originally published from 1970 to 1972.
Captain America is teamed up with the Falcon for most of this run, which was symbolically significant for the time. The Falcon, created by Stan Lee and Gene Colan, had first appeared in issue #117 of Captain America in 1969, and was Marvel's first African-American superhero.
The last of Stan Lee's run on Captain America features SHIELD, Modok, AIM and the Red Skull. Lee is followed by Gary Friedrich, who wrote many Marvel comics in the 1970s. Friedrich sets up Captain America as a beat cop in his secret identity of Steve Rogers, while the Falcon gets more involved in Harlem, fighting slumlords and getting a girlfriend, Leila.
Friedrich wraps up his run in #148, as Cap and the Falcon face the Red Skull and the Fifth Sleeper.
Gerry Conway writes issues 149-153, before Steve Englehart takes over with #154. In the final arc of the storyline, Captain America and the Falcon face off against … Captain America and Bucky. Englehart's run starts off with an interesting tale that also cleans up a bit of continuity; it leads to the next volume, where Englehart gets to more fully explore his take on Cap.
Artists during this run include Gene Colan, Gil Kane, John Romita and Sal Buscema.
- Matt Price
Comics read in 2011: 713 Still to go: 1298


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Letter: A Duty to Wales
Byline: J TREFOR WILLIAMS
SIR - May I comment on the letter from Beryl Roberts, Caerffili (the correct Welsh spelling of this place name)?
Learning Welsh is a patriotic and Christian duty to the people of Wales.
Jean Piaget (1896-1980) the great Swiss psychologist, has shown us that we cannot love our neighbours unless we can understand them; impossible, unless we can speak and understand their own language.
One of the human rights of the United Nations Charter is education through the medium of the mother tongue.
English people in Wales enjoy this as a legal right but Welsh people in England neither enjoy this legal right nor as a human right.
I can assure Beryl Roberts that learning Welsh is not a waste of time or money, nor is it taught by compulsion, any more than English, French or mathematics are taught by compulsion.
In my experience, as a qualified graduate teacher of English as well as Welsh, I have had pupils learning Welsh as a second language showing more enthusiasm for the subject than they have done for English or French. …


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"A Meteoric Rise to Excellence!" Review Thread
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May 16th, 2010 (3:49 AM).
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Ooh, I'm a week late XD Liked the animation and the facial expressions this episode ~
- Gible is doing the same as Turtwig did...
- Hmm...animatiom looks good this episode. Dawn looks pretty and James looks good
- Crazy Kanto running theme :D
- 10 year olds climbing up the side of a cliff...
- Haha, gotta laugh when that Draco Meteor explodes on Piplup...even though I hate this running gag because it gives Piplup more screentime
- "Date Rape Town" o.O
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Editors' Note: The download button opens the iTunes App Store, where you may continue the download process. You must have iTunes installed with an active iTunes account in order to download and install the software. This download may not be available in some countries.
Publisher's Description+
What's new in this version:
- Fixed the bug preventing offers from loading for some iOS 7 guests.Plus enhancements included in 1.7.2:- Multiple improvements to sign-in, including clarified sign-in options and an enhancement to Target sign-in that fixes the annoyance of having to re-enter your email and password every 30 days! Yay!- Piles and piles of bug fixes and performance optimizations.


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"Adventure and Relaxation in the Fiery Arenal" Top 5 Page for this destination Arenal by lashr1999
Arenal Travel Guide: 140 reviews and 397 photos
Our main reason for out 3 hour road trip from San Jose to the Arenal/Fortuna area was to see the Arenal volcano. However, there are many other things to see and do in this area.
For those who love nature, the Arenal area will not disappoint you. There are many hiking trails to provide you with spectacular views of the forests, lake, volcano, waterfalls, birds and other wildlife. The volcano national park has an excellent view of the volcano. In addition, here you can see a wide variety of flora and fauna. The hanging bridges provide different paths and brides where you can see the volcano and the surrounding forest. We saw a variety of birds and lizards during our walk through. There are many other animals which we were not able to see.
For those into adventure try an activity like we did such as zip lining through the forest. Repelling down waterfall is another activity I may consider for a future visit. Other activities such as horseback riding, rafting and ATVing are also offered in this area or close to this area.
When you become tired of all the adventure there are places too relax and take a break from it all. There are resorts, spas and hot springs to rejuvenate you. Why not relax under a hot spring as the natural hot spring water massages your back. The town of Fortuna has ATM's, a few restaurants, shops and internet cafes.
Last but not least the volcano itself will not disappoint you. During the day if you are close by you can hear various rumbling. On a clear night you may see some orange fireworks erupt from the conical dome. Remember not every night is clear and you may only be able to see the show 50% of the time because of the clouds, so plan on staying here a few nights just in case.
- Pros:Relaxation, nature and adventure all in one place.
- Cons:The potholes but they can be fun when AtV'ing
- In a nutshell:Get a rental 4X4 to experience the true Aernall area
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The hanging bridges are located close to the Arenal volcano and the town of Fortuna. They are a series of metallic... more travel advice
This garden is in an out of the way region in the Arenal area. To get to it you have to pass a small town with dirt... more travel advice
Perhaps the best value for an exciting tour is the canopy tour by www.canopy.co.cr It offers you a choice of horseback... more travel advice
Tabacon offers several ways for you to enjoy their hot springs. You can try just their hot springs for $25 or you can... more travel advice
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text: Sam Zuniss 2016-05-29T13:45:36-04:00 Sam Zuniss http://www.huffingtonpost.com/author/index.php?author=sam-zuniss Copyright 2008, HuffingtonPost.com, Inc. HuffingtonPost Blogger Feed for Sam Zuniss Good old fashioned elbow grease. Five Tips for Staying Sane on the Road to I Do tag:www.huffingtonpost.com,2011:/theblog//3.983761 2011-10-10T12:45:00-04:00 2011-12-10T05:12:02-05:00 Sam Zuniss http://www.huffingtonpost.com/sam-zuniss/ Or this. Within any given day, you experience some or all of the following: breathless excitement, fury, crying jags, clutching anxiety, confusion. You are not a bridezilla. You have not been planning this wedding since you were three and Barbie and Ken were your role models for love. You want a simple, meaningful, shenanigan-free wedding and you have somehow ended up a crazy person. If you have wise people in your circle-of-trust, they will tell you this is normal. They will suggest you read books like Sheryl Paul's The Conscious Bride and counsel you on the complexity of times of transition. These people are your rocks; hold on to them with all your might! You may have noticed some of your nearest and dearest are under the impression that your wedding day is about them and must include x, y and z. Weddings are a tricky business; they often stir up as much emotion for families as they do for the couple getting married and the result can lead the most grounded bride or groom-to-be to a state of complete overwhelm. So, how do you stay sane and joyful amidst the chaos of planning and the expectations of others? Five tips: 1. "Discipline" Yourself: Remember being sent to your time out corner? Send yourself (and your partner) there and declare "no wedding talk" zones. Set a weekly movie date, take long walks with the dog together, turn off your ringer and play Scrabble; whatever you two do that brings you back to you. 2. Delegate: If you haven't yet mastered the art of handing off projects, now's your moment. Even (especially!) if you're a Type A/I'll-do-it-myself kinda gal (or fellow) look over your "to do" list and find things that don't require your input and ask for/accept offers of help. Not only will this reduce your workload, it has the added benefit of letting people who love you be a bigger part of your event. 3. Self-Reflect: Take time to reflect on what getting married means to you. What made you want to spend the rest of your life with your fiancé? Create a "mission statement" that captures the bigger purpose of your wedding, and when your great-aunt Mildred demands to meet (again) to discuss the table centerpieces, say it to yourself like a mantra. 4. Set Boundaries: Get clear on which aspects of the wedding are most sacred to you and your betrothed and tactfully let any overbearing friends or relatives know that while these elements are not up for discussion, you would welcome their input in other areas of planning. Setting boundaries might not make you popular with the more challenging people in your life, but it will give you peace of mind to know you are being true to yourself and preserving what matters most. 5. Challenge "Perfect": The words "perfect" and "wedding" don't belong in the same sentence, but they've become culturally interlocked, with pressure especially sky high for brides. What achievable word best captures how you want your wedding to feel? Romantic? Sacred? Fun? Let that be your beacon (and your screen saver!) and take "perfect" out of your planning vocabulary. Try these tips and cultivate your own. Ask married friends what helped them cope through the more trying times. Remember, any and all feelings that come up are normal. Be good to yourself and allow yourself as much room as possible to feel your feelings without judgment. It's a time like no other, for better and for worse, and it is for something wonderful. Just as pregnancy and labor lead to a precious baby, you're "birthing" a beautiful marriage that's yours and yours alone. ]]>


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Serene wrote:With respect, I think you are making a judgement without full possession of the facts.
Serene wrote:My point, re: totalitarianism, is not to put dictionary definitions in the way, but to point out that even if we were to agree the US restricts its citizens, the gulf between this and totalitarianism is really quite large. The fact that people like Alex Jones continue to run anti-government messages without being silenced is - to me - quite a clear example of how the US is not totalitarian.
you have the right to protest. you have the right to protest effectively, get media coverage, get popular support...as long as you're on the right, or at least not too harsh on the right. if you're not, and you start being effective, we'll do everything in our power to stop you, right down to entertaining the possibility of assassinating people.
someone please explain to me how this is not totalitarianism in effect. because from my perspective this is yet another occurrence of the US government and its supporting interests actively suppressing popular leftist movements. and only leftist movements. no one has said fucking anything about sniping gun-toting teabaggers, the worst that happened to them was -gasp- the IRS actually enforced 501(c)(4) properly on them.
Hedonismbot wrote:Ok, yes, people who are saying this: We do not have guaranteed definite information that whoever was plotting was a government entity. Yes, there's doubt there. Yes, it might have been Joe the Plumber writing in his journal. That's possible.
However, while there is no absolute proof, there's plenty that looks a lot like pretty good evidence. That's the strongest logical assertion. It looks, very much, like one branch of the government was allowing another branch of the government to plan to assassinate innocent civilians for their political views. That is very bad, whether you actually want to call it specifically totalitarian or not. Feel free to put forth a term that you'd prefer, but it'd be nice if you'd discuss the actual topic, too.
ceepolk wrote:No idea Setar, but while i haven't been posting, I have been reading, and I don't really understand what about your post is a conspiracy theory. I don't think you're saying anything outlandish at all. it's fair to say that the U.S. Government has engaged in covert operations - from illegal surveillance and constitutional violations to assassinations against its own citizens for decades (see Martin Luther King for the assassination example,) and you'd have to be pretty young to not realize how far down the totalitarian drain drain the 21st century US has slid, and Canada following along after.
Hedonismbot wrote:No, I'm pretty sure I didn't assert anything blatantly ridiculous that would count as a "conspiracy theory" as most here would understand it. A theory about a conspiracy? Sure. But it is not unevidenced or held in contradiction to better evidence. It also has the weight of history: as Setar said, the US government has an unfortunate history of doing exactly this sort of thing. All of the language used seems to indicate that an official organization or someone affiliated with an official organization was behind the plot. There's plenty of reason to suspect a government plot here. No one's saying that the Moon Landing was actually filmed using tiny models on the back of a shaved horse. We're saying that there is an FBI document that looks very much like it details a plan by law enforcement to do something shitty that law enforcement has been known to do.
I'm not going to flip out about it until I have better evidence, but this certainly reads like a "Holy shit, that sounds bad! We should try to get it properly investigated!" situation.
Setar wrote:-comes back and reads thread-
Why do I get the feeling that there's a concerted effort to derail this conversation away from concepts like inverted totalitarianism or totalitarian democracy; in other words, that the US has all the trappings of a "free and democratic society" but in reality is not that at all?
Zeitgueist wrote:The FBI is the secret police of the USA. What confuses people is that it doesn't refer to itself as secret police, and secret police is something that happens "over there, in those countries".
qmartindale wrote:Zeitgueist wrote:The FBI is the secret police of the USA. What confuses people is that it doesn't refer to itself as secret police, and secret police is something that happens "over there, in those countries".
The FBI, as a matter of policy, refuses to record interrogations. That's all that needs to be said.
eirefrance wrote:qmartindale wrote:Zeitgueist wrote:The FBI is the secret police of the USA. What confuses people is that it doesn't refer to itself as secret police, and secret police is something that happens "over there, in those countries".
The FBI, as a matter of policy, refuses to record interrogations. That's all that needs to be said.
As cynical as I am (though less cynical than many), this really surprises me. It seems I have to continuously roll back my expectations for accountability from the US govt.
Wowbagger@LousyCanuck: Here's a novel thought: try contemplating the idea that there are people who aren't you. No, really. Take your time. Once you've managed that and pondered the implications, maybe you'll be able to grasp what's going on here.
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Services, National Institutes of Health
|Services, National Institutes of Health Patent applications
|Patent application number
|DIRECT IMPACT IONIZATION (DII) MASS SPECTROMETRY - Disclosed is a mass spectrometer for analyzing a sample that has or is suspected of having microorganisms. The disclosed mass spectrometer has been uniquely configured to include a sample platform which functions as a counter electrode or discharge electrode and a surface to provide the sample to be analyzed. The mass spectrometer also includes an ion source positioned adjacent to the sample platform for ionizing and volatizing molecules within the sample, wherein the sample platform and the ion source are positioned such that during operation of the mass spectrometer an electrical discharge takes place between the ion source and the sample platform. Also disclosed are methods for generating a mass spectrum profile/fingerprint of a sample. The methods include positioning a sample platform having a sample adjacent to an ion source.
|TRANSCATHETER CORONARY SINUS MITRAL VALVE ANNULOPLASTY PROCEDURE AND CORONARY ARTERY AND MYOCARDIAL PROTECTION DEVICE - A protective device or bridge comprising a central arch is suitable to be placed between an annuplasty device placed in the coronary sinus and an underlying coronary artery to inhibit transmission of compressive force on the coronary artery by the annuplasty device.
|PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE - This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
|PHOTOSENSITIZING ANTIBODY-FLUOROPHORE CONJUGATES - The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm
Patent applications by Services, National Institutes of Health


text:
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text:
Which Countries Are the East's Most...
RNAi Is Working on Tactics to...
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To Know Where Biosimilars Are Going,...
The European Commission approved Roche and Plexxikon's melanoma drug Zelboraf (vemurafenib) for the treatment of BRAF V600-mutation positive unresectable or metastatic disease. Roche's cobas 4800 BRAF V600 mutation test, which is used to identify patients suitable for Zelboraf therapy, has already been granted a CE mark in the EU. Zelboraf and the companion cobas test were approved in the U.S. in 2011, and approvals have been granted or filed in other territories globally.
Zelboraf is an oral small molecule kinase inhibitor. Approval of the drug in the EU was based on data from the 675-patient Phase III BRIM3 trial, which demonstrated that in comparison with standard first-line dacarbazine chemotherapy, use of Zelboraf to treat BRAF V600 mutation-positive metastatic melanoma reduced the risk of death by 63%. A subsequent post hoc analysis after longer follow-up also showed that the kinase inhibitor boosted overall survival from 9.6 months to 13.2 months. The cobas 4800 BRAF V600 mutation test was validated through the BRIM3 trial and open-label Phase II BRIM2 study.
Zelboraf is being developed under 2006 license and collaboration agreement between Roche and Plexxikon, which is part of Daiichi Sankyo. The drug is being co-promoted in the U.S. by Daiichi Sankyo and Genentech. Roche and Genentech are progressing a broad development program for the drug as monotherapy and combination therapy in a number of tumor types.
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The Super Starter Pokémon Club!
View Single Post
September 16th, 2012 (8:21 AM).
I am still bathing in a summer's afterglow
Silver Tier
Join Date: Aug 2010
Location: Skyloft
Gender: Male
Nature: Quiet
Posts: 2,605
Would you have preferred a versatile starter, like Eevee (which is not), in a game?
Well, there aren't really many versatile Pokemon in the game apart from Eevee, though that's also why Eevee would be the ideal starter. With all its evolutions, you're free to choose whichever element you want your starter to be, granted that you come across the stones relatively early in the game compared to the first generation, where you only get a few, mainly moonstones, before Celadon. Same with the third generation, where most stones are to be bought from the man at Mossdeep, otherwise it won't really work out. There's a lot of variation in how powerful the evolutions are though, so the main evolutions to be chosen would probably be strong ones, like Vaporeon, so while there is diversity, I don't think it'd be put to much use by the players.
All in all, I guess I'd have to say no. If all Eevee's evolutions were just close to being equally powerful, maybe it'd be worth considering, but with the huge differences, it just wouldn't work out, and it'd just end up being straightforward anyways.
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The pretend tears that are elicited by telling a pretend story about a pretend bear that eats a pretend family at the request of a real three-and-a-half year old, last just as long, and are just as loud as the real tears that might have ensued after sharing a nonfiction story with the same plot.
Tag Archives: crying
January 15, 2013 · 4:13 pm
Parenting Tip of the Day:
Filed under parenting tips of the day
Tagged as advice, bear, crying, fiction, parenting, parenting tip, story, storytelling, three year old, tip
July 10, 2011 · 2:42 pm
Parenting Tip of the Day:
When your toddler points at your face and says, "this is a monkey butt," try not to cry. Monkey butts don't cry.
Filed under Uncategorized
Tagged as advice, crying, Parenting advice
June 10, 2011 · 1:16 pm
Parenting Tip of the Day:
Turning up the radio in the front seat makes any crying in the backseat less audible.
Filed under Uncategorized


text:
More New and Used
from Private Sellers
Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
Biological Inquiry A Workbook of Investigative Case Studies
ISBN13:by Campbell, Neil A.; Reece, Jane B.; Waterman, Margaret B.; Stanley, Ethel
Questions About This Book?
What version or edition is this?
This is the 2nd edition with a publication date of 12/11/2007.
What is included with this book?
- The Used copy of this book is not guaranteed to include any supplemental materials. Typically, only the book itself is included.
Related Products
This workbook offers an investigative case study for each unit of the book. Each case study requires students to synthesize information from one unit of the text and apply that knowledge to a real-world scenario as they evaluate new information, analyze evidence, plot data, or seek explanations. This workbook includes two new case studies: one on avian influenza, and one onhedgehogdevelopmental pathways.


text:
December 04,2012RUDOLPH, Ohio Volunteers in the northwest Ohio village of Rudolph have come together to save the most famous postmark of all. Thousands of letters flood the village post office every December so they can be stamped with a Rudolph the Red-Nosed Reindeer postmark. But the tradition was in danger of ending when the post office staff was cut down to one and the work became too much to handle. Thats when volunteers in the community decided to take over the job. When word spread, pleadings from local politicians and townsfolk persuaded the U.S. Postal Service to allow volunteers to stamp the special Reindeer Station postmark on the 80,000 letters and cards that come in from across the country. Close to 75 people, including a few retired postal workers, have signed up to work daily shifts.
The Associated PressMORE IN Wire NewsHONOLULU Hawaii could become the first state in the United States to enter gun owners into an... Full StoryLOS ANGELES Democratic presidential candidate Bernie Sanders says the Democratic National... Full StoryDETROIT Hillary Clinton said Monday that Donald Trumps economic policies would lead to lower... Full Story
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Whipping up a morning smoothie seems like a foolproof way to start your day. It's easy to watch your portions, chock-full of nutrients, and better for you than sugar-laden cereal—right? Not always. Blitzing a bunch of fruit together can spike your blood sugar faster than a Ferrari and kick your cravings into high gear, warns Christine Avanti, RD, author of Skinny Chicks Eat Real Food.
But smoothies don't have to mean hunger pangs and an emergency pit stop at Dunkin' Donuts. The key is adding ingredients that help but the brakes on cravings. "Fiber and protein are key in helping keep you fuller for longer—and because fats don't increase blood sugar levels, they don't trigger cravings for more carbs," says Katherine Brooking, MS, RD, coauthor of The Real Skinny. Whip up one of these five healthy and hearty smoothies that'll satisfy you all morning long.
Bonus download: Click here to download 10 filling smoothies—including five exclusive recipes!


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Profile Fields:
Does Paid Memberships Pro have its own Custom Profile Fields, or does it use WordPress profile fields? Can custom profile fields be added via wp-admin or only via code?
Custom Post Types:
Can it control access to custom post types, type by type, like 'gold' members can access the 'bestever' post type?
Thank you.


text:
Developmental Plan for Merging RBPG and RLTPG
In the past couple of months, the Board members of the RBPG and RLTPG have established a Planning Committee to develop plans for a potential merger of our two professional groups. Our purpose would be to establish a Society for Embryologists and Technologists which strives to support the continuing education, growth and development of laboratory specialists working in all disciplines of reproductive biology, and to promote standards of excellence in laboratory applications and research. This society would encourage the active participation of all members in order to provide a unified foundation for laboratory personnel to make positive contributions to the ASRM. The goals of membership activities would encompass:
All members of ASRM, independent of degree qualifications, would be eligible to join and participate as members. All members of the society would be eligible to participate in all scientific program activities, interactive web-based information resources, surveys and patient education programs. A two-tiered membership has been proposed to keep annual dues to a minimum for associate members, while active members would be eligible to participate in all nomination/election activities, and therefore would be eligible to serve on the Executive Board and its Committees, as an appointed or elected official. It is anticipated that senior level-scientists, Ph.D. and non-Ph.D., would join as active members. This system will make it easier for us to attain our projected budgetary goals: a start-up budget of $11,000 in Year 1, and a stable working budget of $20,000 by Year 3.
The specific structure and bylaws of the proposed society will be developed with membership input once initial approval is granted by the membership to proceed, as determined by an upcoming survey of the membership. In general, we anticipate implementing a Board of Directors, which includes a rotational election of Ph.D. and non-Ph.D. lab scientists (as per the RLTPG bylaws) to the position of President-elect (Vice-Program Chair), Program Chair, President and Past President; and to a Nomination Committee (as per the RBPG bylaws). Other positions appointed by the Executive Board would include a Secretary, Treasurer, and Information Director, as well as other committees to be determined. Two members of the Executive Board would meet bi-annually with the ASRM Board. Overall, we would try to integrate the bylaws of the two PGs, as much as possible.
In terms of our conference and program activities at the annual ASRM meeting, we would strive to maintain the current established standards: Four scientific sessions aimed at Human Studies I, Animal & Experimental Studies I, and Lab Technologies I & II; 10 Roundtables; an Interactive Session with a SIG/PG; and a two-day postgraduate course with optional 1- or 2-day attendance in a basic science/lab tech-based PGC. It would be up to us to justify our scientific needs and make our formation contingent on this plan.
Beyond this, the sky is the limit for a Society for Embryologists and Technologists. The development and growth of this society would be up to the active participation and input of its members.
Why Merge and form an Affiliated Society Now?
Over the past two decades, we have contributed significantly to the scientific integrity and technological advancement the IVF Industry and our society, the ASRM. We have matured as professionals within the ranks of the ASRM and are ready to maintain a leadership role within ASRM, on behalf of lab scientists. Our petition to be an affiliated society is justified, as we constitute more than 1/8th of the total ASRM membership with more than 1,450 combined members, exceeding that of any of the existing societies. However, membership may decline, and possible ASRM participation, as new lab-specific organizations form and continue developing. Yet, even if only 60% of our current members decided to join and pay annual dues as associate or active members, our membership would be equal to the most populated group, the SREI. We do not have to become an incorporated entity, which would keep our operating expenses low and, in turn, membership dues low, similar to the SMRU. We can continue to operate under the organizational infrastructure of the ASRM, with improved website capabilities and internet communications, as a society. Furthermore, as an affiliate society we would have direct representation and one vote on the ASRM Board of Directors and representation on major ASRM committees. The ASRM bylaws allow up to six affiliated societies to have voting representation on the ASRM Board, currently there are four such groups. As an affiliated society, we would not have to lose anything, in terms of the scientific program. It would be up to us to justify our annual scientific needs based on membership participation. The RBPG and RLTPG executive boards believe the time has come for us to make a cohesive team effort to become the fifth Society affiliate and strengthen our members' link to the ASRM Board. If you have any questions and concerns you wish to discuss, feel free to contact Mitch Schiewe at 949-642-5954 (email@example.com) or any other Board member.
-- MC Schiewe, Planning Committee Chair
Thousands of doctors, nurses, and other professionals in the field of reproductive medicine are advancing their careers with the latest news, continuing education, discounts, and networking opportunities. Here are 15 reasons you should consider joining ASRM:News and Education
•Access to the Society's journals, Fertility and Sterility and the Journal of Assisted Reproduction and Genetics •CME/CE credits in-person and online through ASRM eLearn® •Updates on the latest reproductive health policy news from our D.C. office •Access to printable Practice Guidelines and Ethics Statements
Professional Development and Recognition •Networking opportunities including online listservs and small group meetings •Input into shaping policies and protocols through member groups •Eligibility to receive ASRM research grants and awards •Listing of providers in the patient "Find a Healthcare Professional" directory
Specials and Discounts•Free CME, CE and PEER credits through ASRM eLearn® (Excludes certificate courses) •Discounts on ASRM Scientific Congress & Expo registration fees •Members-only rates on ASRM products and services
•Access to an online member login account •Full access to the ASRM Membership Directory •Member discounts on job postings on the ASRM Career Center •Answers to CPT coding questions at the Coding Corner
Click here to learn more about how ASRM membership would benefit you.Member Services Department(205) firstname.lastname@example.com
Members are allowed to have direct input in shaping policies and protocols in their area of expertise through ASRM affiliated societies, professional groups, and special interest groups.
Affiliates: SART | SMRU | SREI | SRBT | SRS
Professional Groups: ARM | LPG | MHPG | NPG
Special Interest Groups: AESIG | CAMSIG | ChSIG | CSIG | EndoSIG | EPSIG | ERSIG | FPSIG | FSIG | HDSIG | GCSIG | IRMSIG | MSIG | NutriSIG | PAGSIG | PGDSIG | PSSIG | RISIG | RMSCBSIG | TSIG | WC
©1996 - 2016 ASRM, American Society for Reproductive Medicine. All Rights Reserved.


text:
Hotel Details Local Guide
- This hotel is in a suburban location
- Closest City: LAFAYETTE
- Local Time Zone : GMT-5
Indianapolis International Airport (IND)
Chicago Midway Intl. (MDW)
Chicago O Hare Intl. (ORD)
Nearest Train Station
Nearby Businesses
Subaru of Indiana Automotive
Wabash National Corporation
Alcoa Lafayette
What's New
It's always a good idea to check and see what's currently happening at Purdue University. The hotel's location is just 6.5 miles from the university. Get tickets to a basketball game at Mackey Arena or see what productions are onstage at the theatre.
If you're here for an extended stay in Lafayette, take some time to explore the golf courses in the area. The city has a scenic municipal course, which is open year-round, and there are several other courses to choose from close to our location off I-65.
Don't Go Home Without
Don't leave Lafayette until you've sampled the arts with the Lafayette Symphony Orchestra, located right across the Wabash from Purdue University. The hotel's location is four miles from the home of the Symphony, the Long Center in historic downtown.
Must See
An extended stay in Lafayette should be complemented with a walk through historic downtown. Visit the Red Crown Gas Station, a mini-museum on the corner of 6th and South that is a restored 1930s Standard Oil filling station featuring old-time artifacts.
Must Do
You'll love spending a day at Columbian Park in downtown Lafayette. There are plenty of beautiful open spaces in which to enjoy a picnic and there's even a lazy river and a stunning collection of more than 190 species of animals at the Columbian Park Zoo.
Theme Park
Indiana Beach Amusement Resort
Distance from hotel: 33 MI/ 53.11 KM North East
Race Tracks
Indianapolis Motor Speedway
Distance from hotel: 60 MI/ 96.56 KM South
Sports Venue
Ross-Ade Stadium (home of Purdue)
Distance from hotel: 10 MI/ 16.09 KM West
Lucas Oil Stadium (home of the Colts)
Distance from hotel: 61 MI/ 98.17 KM South
Museum or Gallery
Distance from hotel: 60 MI/ 96.56 KM South
Park Details
Columbian Park


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Mr. and Mrs. David Louis Goodwin of Concord and Mr. and Mrs. Donald Elwood Edwards of Norwood, announce the engagement of their daughter, Dacie Elaine Edwards, to Jess Lee Edwards of Kinston, son of Janet Carroll Edwards of Salter Path and Mr. and Mrs. Millard Carl Edwards of Morehead City. An April 2014 wedding is being planned in Kinston.
Location, ST | website.com


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.- According to Aid to the Church in Need's 2005 report on religious freedom, persecution of Christians in Asia is on the rise, with thousands suffering torture, prison or death at the hands of political and religious leaders in Asian countries.
The Spanish daily La Razon published excerpts from the report, noting that the Asian continent-including the Middle East-is where the greatest number of abuses of religious freedom takes place. "In certain regions, for example, speaking in public about any religion other than the official State religion is prohibited. In others, Christian worship is a sufficient reason to end up in jail. The case of China, where Catholics can only profess their faith 'by joining' a national organization that controls their movements (the Patriotic Catholic Association), is one of the most criticized cases in the report," the newspaper indicated.
The report also noted the case of India, "where growing Hindu nationalism and recent 'anti-conversion' laws have resulted in attacks against Christians," including several deaths that have yet to be investigated.
In Asia and the Middle East, the countries with the greatest incidences of persecution include Iraq, the Palestinian Authority, China, Saudi Arabia, Iran, India, Sri Lanka, Laos, Vietnam and North Korea.
The report also notes the religious persecution taking place on other continents. In Africa, there has been a decrease in Morocco and Tunisia, but the situation has worsened in Algeria, Kenya, Nigeria, Eritrea, Libya, Rwanda, Mauritania and Egypt. Europe does not escape criticism either. Aid to the Church in Need notes an increase in radical secularism affecting the Church in Russia, Georgia, Serbia and Bosnia.