text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Date de publication
|2 avr. 1996
|Date de dépôt
|21 oct. 1994
|Date de priorité
|21 oct. 1994
|État de paiement des frais
|Numéro de publication
|Michiel M. Van Oort
|Cessionnaire d'origine
|Glaxo Wellcome Inc.
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Citations de brevets (9), Référencé par (32), Classifications (11), Événements juridiques (4)
|Liens externes: USPTO, Cession USPTO, Espacenet
The present invention relates to a medicament carrier, and more particularly to process for forming a carrier containing a dry powder medicament thereon and which is adapted to be positioned within a dry powder inhalator.
Asthma and other respiratory diseases are typically treated by the inhalation of an appropriate medicament for deposition in the lungs to ease patient breathing and increase air capacity. The most widely used treatments for respiratory diseases have been (1) the inhalation of a medicament from a drug solution or suspension in a metered dose aerosol, pressurized inhalator and (2) the inhalation of a powdered drug (generally admixed with an excipient) from a dry powder inhalator. However, in view of recent evidence of the link between chlorofluorocarbon emissions and the deterioration of the earth's atmospheric ozone layer, use of drugs in pressurized inhalators is less desirable and interest in dry powder inhalation systems has substantially increased.
Applicant is presently aware of several different basic methods in use to provide fine particle powders to the respiratory tract without the use of undesirable chlorofluorocarbon propellants. The first method utilizes hard gelatin capsules which contain both a dose of the active material and, in addition, potential adjuvants. The inhalator used by the asthmatic patient for this method comprises a device for perforating or opening the capsule which is then inserted into the inhalator when needed. An air stream generated by the patient on a mouthpiece of the inhalator serves to remove the powder contained within the opened capsule. The empty capsule is then expelled from the inhalator, which is then ready to receive the next capsule. The air stream which passes through the capsule during inhalation acts to remove the powdered medicament from the broken capsule, but it has been found that the air stream created by the patient using this type of inhalator is generally not sufficient in duration to remove all of the contents from the capsule. Dry powder inhalators using this technology are disclosed in a number of prior art references including U.S. Pat. Nos. 3,906,950; 4,013,075; 3,807,400; and 3,991,761.
Another type of inhalator device is loaded with a package having a number of blisters which are spaced apart from each other. Each blister contains a fixed quantity of powdered medicament for administration to the patient. As each blister is moved into a predetermined position, it is broken by a suitable means so as to release the powder which is in turn inhaled by the patient. However, it has been found that moisture ingress into the blister pack can cause agglomeration of the prepared medicament therein. Consequently, when the prepared medicament is inhaled by the user, the preferred particle size for greatest efficacy in respiratory disease treatment may not necessarily be achieved. Moreover, the operation of the device requires the use of excipients (e.g., lactose) in order to meter and administer the medicament. This type of inhalation device is disclosed in a number of prior art patent publications including EPO Patent Application Publications Nos. EPO 211595; EPO 455463; and EPO 467172 A1.
Yet another type of dry powder inhalator contains a quantity of medicament therein which is sufficient for multiple doses. A representative example of this type of device is the Draco TURBUHALER® which is disclosed in U.S. Pat. Nos. 4,668,218; 4,667,668; and 4,805,811. The inhalator includes a device for withdrawing powdered medicament from the container and for preparing a dose for inhalation. The withdrawal and dose preparation includes a plate having a predetermined thickness and a number of cup-shaped holes therethrough. The plate can be moved by mechanical means from a position where a proportion of the holes are filled with powdered medicament taken from the container to another position in which the holes filled with the medicament are located within a channel. Air flows into the channel as a result of suction provided by the patient on a mouthpiece in fluid communication with the channel so as to remove the powdered medicament from the holes. However, it has been found that when suction is applied to entrain the medicament from one or more holes in the plate, not all of the medicament is entrained in the air flow. Moreover, the TURBUHALER® device is designed to administer large doses and is prone to significant variations in drug delivery.
A fourth dry powder inhalator device is disclosed in German Patent No. 4020571 A1 wherein a velour or velvet-type material loaded with powder is introduced into a jet stream of air. The airstream acts to lift the powder from the velour-like material and to entrain the powder within the airstream which is then in turn inhaled by the patient. One shortcoming of this type of inhalator device is that there is a tendency for the carrier fibers to intermix with the medicament.
A new type of carrier disc for a dry powder inhalator which has recently been proposed is disclosed in U.S. patent application Ser. No. 08/025,964 filed Mar. 3, 1993, now abandoned, which teaches a screen mesh disc which is impregnated at spaced locations or portions along its circumference with a dose of powdered medicament, such as salmeterol hydroxynapthoate, which can be useful in the treatment of asthma. Since the powdered medicament is impregnated into the interstices of the screen portions, the air impinging upon the screen portions and the powdered medicament during inhalation will cause the medicament to break up so as to aerosol or atomize the medicament. Further, the interstitial deposit of the medicament on the screen portions allows turbulent air to surround each medicament dose and entrain it to assist complete dispensing of the medicament dose from the screen portions into the airstream. However, the use of the screen disc in the dry powder inhalator device also suffers certain shortcomings including imprecise metering of the powdered medicament since the screen portion interstices are used to meter the medicament. Other shortcomings of the interstitial deposit of the powdered medicament (or impregnation of the medicament) into the screen portions are limitations of dose size to interstitial volume, and the necessity to deaggregate large clusters of medicament present in interstitial voids.
Applicant's present invention avoids many of the problems associated with prior art dry powder inhalators by providing a novel medicament carrier which allows a predetermined and precise dose of the dry powdered medicament to be supplied through the inhalator device upon demand. Moreover, applicant's invention provides much greater flexibility in medicament dose range with a specific carrier screen portion size since the medicament dose is not dependent on the interstitial void volume of the carrier screen portion.
In accordance with the present invention, a medicament carrier is provided which is adapted for use in a dry powder inhalator device and includes at least one carrier screen portion defining a plurality of interstices therein and loaded with at least one dose of a powdered medicament. The powdered medicament is loaded onto the carrier screen portion surface such that the interstices thereof are at least partially open and free of the powdered medicament.
Also, in accordance with an alternative embodiment of the present invention, a medicament carrier for use in a dry powder inhalator device is provided which comprises two spaced-apart screens wherein each screen defines a plurality of interstices therein. A plurality of substantially spherical substrate elements are positioned between the two screens which are loaded with at least one dose of a powdered medicament such that the powdered medicament is removed from the surface of the spherical substrate elements when an air flow is introduced through the two spaced-apart screens of the medicament carrier.
It is therefore the object of the present invention to provide a medicament carrier for use in a dry powder inhalator which provides for administration of a predetermined precise dosage of the powdered medicament.
It is another object of the present invention to provide a medicament carrier for use in a dry powder inhalator device which provides for the ingested particle size of the powdered medicament dose to be formed for maximum beneficial efficiency.
Some of the objects of the invention being stated, other objects will become evident as the description proceeds, when taken in connection with the accompanying drawings described hereinbelow.
FIG. 1 is a perspective view of a first representative medicament carrier cassette for use in a dry powder inhalator device in accordance with the present invention;
FIG. 2 is a perspective view of a second representative medicament carrier cassette for use in a dry powder inhalator device in accordance with the present invention;
FIG. 3 is a perspective view of a third representative medicament carrier cassette for use in a dry powder inhalator device in accordance with the present invention;
FIG. 4 is a perspective view of an individual medicament carrier such as utilized in the representative cassettes shown in FIGS. 1-3;
FIG. 5 is an exploded perspective view of the medicament carrier shown in FIG. 4;
FIG. 6 is an exploded vertical cross-sectional view of the medicament carrier shown in FIG. 4;
FIG. 7 is a schematic view illustrating application of a suspension solution of a powdered medicament being applied to the medicament carrier screen portion shown in FIGS. 5 and 6;
FIG. 8 is an enlarged, perspective view showing loading of the powdered medicament onto the medicament carrier screen portion surface after evaporation of the suspending agent such that the interstices of the medicament carrier screen portion are at least partially open and free of the powdered medicament;
FIG. 9 illustrates the medicament carrier of the present invention and the effect thereupon when subjected to an inhalation air pulse;
FIGS. 10A and 10B show a plan view and an enlargement of a selected portion thereof, respectively, of a medicament carrier screen portion with an accreted powdered medicament loaded thereon; and
FIG. 11 illustrates a second embodiment of the medicament carrier of the present invention wherein the carrier comprises two spaced-apart screens having a plurality of substantially spherical substrate elements positioned therebetween which are loaded with powdered medicament and the effect thereupon when subjected to an inhalation air pulse.
Referring now to FIGS. 1-11 of the drawings wherein like numerals indicate like elements throughout the several views, three (3) embodiments of medicament carrier cassettes are illustrated in FIGS. 1-3 which each include a number of spaced-apart medicament carriers 10 therein which form the subject of the instant invention. Powdered medicaments which can be used with the medicament carrier of the present invention for inhalation therapy of systemic absorption via the respiratory tract include, but are not limited to, albuterol, terbutaline, isoproterenol, metaprotaranol, pirbuterol, salmeterol hydroxynapthoate, fluticasone propionate, budesonide, beclomethasone dipropionate, and triacetonide. Moreover, it is understood that the powdered medicaments may optionally be admixed with excipients such as lactose and glucose.
Referring more specifically to the drawings, medicament carriers 10 are shown in FIGS. 4-6. Medicament carriers 10, a plurality of which are included in each of representative medicament carrier cassettes of FIGS. 1-3, are formed from carrier screen portions 12 which most suitably are secured or sandwiched between enclosure screens 14 and 16, although screens 14 and 16 would not be required in other embodiments of medicament carriers 10 in accordance with the present invention. It should be appreciated that medicament carrier cassettes of FIGS. 1-3 are configured so as to be insertable into any suitable breath-activated dry powder inhalator (not shown) such as are well known in the art and that novel medicament carriers 10 of the present invention could be incorporated into many other types of sheets, plates, discs and the like in addition to the three depicted representative cassettes.
The carrier screen portion 12 can be a non-woven or woven screen formed from natural or synthetic fibers or stamped from a metal blank or photoacid etched from stainless steel or ceramic or formed in any other suitable fashion, so as to provide a plurality of interstices 12A (see FIG. 8) therein. Applicant's invention provides for depositing a prescribed dose of a dry powdered medicament substantially on the surface of carrier screen portion 12 (see FIG. 8) and not primarily within the interstices 12A thereof. The size of the dose depends upon the drug used. For example, a common drug used for asthmatics is salmeterol hydroxynapthoate which is normally dispensed in single doses of about 50 micrograms (μg). Thus, each medicament dose of such a drug could be deposited on the surface of a selected carrier screen portion 12 which is most suitably formed so as to be about 0.06-0.25 inches in diameter in size and to have interstices therein measuring approximately 0.0005 inches or more in width. As noted hereinbefore, carrier screen portion 12 may be formed in many ways including a non-woven or woven screen formed from natural or synthetic fibers or stamped from a metal blank or photoacid etched from stainless steel or ceramic material.
Carrier screen portion 12 is formed with interstices 12A of approximately 0.0005 inches or more in width and (optionally) is secured or sandwiched between enclosure screens 14 and 16 so as to form medicament carrier 10. It is to be understood that medicament carrier 10 could be formed exclusively from carrier screen portion 12 as a matter of design choice in forming medicament carrier 10. A plurality of medicament carriers 10 are positioned on the perimeter of a medicament carrier cassette such as the rings shown in FIGS. 1 and 2, respectively, or along the length of a medicament carrier cassette tape such as shown in FIG. 3. Optional enclosure screens 14 and 16 each permit access of an external air flow or air pulses through the exposed area of medicament carrier 10 when the carrier is positioned within a suitable dry powder inhalator device (not shown) so that the powdered medicament can be entrained in the air (see FIG. 9) which is then inhaled by the patient through the inhalator mouthpiece (not shown) which communicates with the air flow. By suitable mechanical or electromechanical means, medicament carriers 10 within medicament carrier cassettes such as shown in FIGS. 1-3 are selectively indexed to present a new dose of a powdered medicament to the air flow or air pulse of the inhalator device.
Since the powdered medicament is primarily deposited on the surface of carrier screen portion 12 and spans a significant number of interstices of carrier screen portion 12 (see FIG. 8), the number of particles in physical contact with each other is significantly reduced and therefore the amount of energy required to deaggregate the particles into the respirable particle size range is minimized (as opposed, for example, to strictly interstitial deposit of the powdered medicament). The thickness of the layer of powdered medicament on the surface of the elements forming carrier screen portion 12 can be selected so as to minimize the degree of particle-particle contact and/or the size of particle microclusters. The air pulse directed at the dry powdered medicament will serve to sweep the dose of powdered medicament off of carrier screen portion 12, to suck the dose off of carrier screen portion 12 by virtue of the Bernoulli effect and/or to burst through the dose bridging the interstices.
Applicant has discovered that the high shear forces and turbulence experienced by the deposited powdered medicament will result in removal and/or deaggregation of the particles or microclusters of the particles. Thus, each interstice 12A of carrier screen portion 12 will act as a nozzle or jet if any particles are not directly adhered to the surface of the elements defining carrier screen portion 12 but are accreted thereto (see, for example, FIGS. 10A and 10B).
Screen 14 (which, as previously noted, is optional and not a required element of the medicament carrier of the invention) is utilized so as to further aid in the deaggregation of the drug particles due to impaction and high shear forces resulting from contact of the powdered medicament (removed by the air flow from carrier screen portion 12 and entrained in the air flow therethrough) with screen 14. Also, upstream screen 16 serves to modify the air flow so as to maximize turbulence and shear to facilitate deaggregation of the powdered medicament.
An alternative embodiment of applicant's invention contemplates providing medicament carrier 20 (see FIG. 11). which does not require deposition of dry powder medicament directly onto the surface of the elements defining carrier screen portions 12. Alternative embodiment medicament carrier 20 comprises substantially spherical substrate elements 22 formed from materials such as organic or inorganic materials such as metals, polymers or polysaccharides and upon the surfaces of which the dry powdered medicament is deposited. Spherical substrate elements 22 are carried between two screen elements 24 and 26 so as to position spherical substrate elements 22 in the air flow or air pulse through the exposed area of medicament carrier 20 within the air flow channel of an inhalator so that the dry powder medicament can be entrained in the air or aerosolized for inhalation by a patient. Medicament carrier 20 is positioned with an inhalator device (not shown) so that the interstices of screen elements 24 and 26 serve functionally as air jets in order to facilitate deaggregation and removal of the dry powdered medicament from the surfaces of spherical substrate elements 22.
Applicant's novel medicament carriers 10 and 20 are most suitably formed by metering small quantities of selected medicaments in the form of a suspension on carrier screen portions 12 or carrier spherical substrate elements 22 and then evaporating off the suspending media. The suspending media should be relatively non-toxic, low or non-flammable, and possess a boiling point near or slightly above room temperature in order to be suitable for a production setting. Applicant has found that perfluoropentane, perfluorohexane, perfluoromethylcyclohexane and perfluorocyclohexane serve as good suspending media, although other suspending media are contemplated as being within the scope of the present invention (including fluorinated hydrocarbons and/or hydrocarbons).
The disc, ring or strip or the like that will become a drug cassette (such as shown in FIGS. 1-3) will be passed into a drug filling zone in the manufacturing process. The manufacturing drug filling zone will consist of an arrangement of spray nozzles or needles N (see FIG. 7) that will meter out a predetermined amount of a drug as a suspension or solution S of the drug onto carrier screen portions 12 or onto spherical substrate elements 22. Since it is desirable to remove the suspending medium described hereinabove, a sufficient time will be permitted to pass to allow the suspending medium to evaporate. Optionally, heat and/or a small positive or negative air pressure may be applied to carrier screen portions 12 or substantially spherical substrate elements 22 to facilitate evaporation. Thus, the essence of applicant's manufacturing process is the application of the drug onto the surface elements of carrier screen portions 12 and spherical substrate elements 22 so as to leave the interstices therebetween substantially open and free of all drug.
Applicant utilized an extensive survey to select an appropriate suspending medium for dry powder medicament to be applied to the carrier screen portions of the drug carriers of a medicament carrier cassette (e.g., sheet, plate, disc, tape or the like having a plurality of medicament carrier screen portions therein). The selection criteria can include non-flammability, non-toxicity, a boiling point close to room temperature (for high vapor pressure and low energy input to remove the liquid), and low environmental impact. Applicant found perfluoropentane to be a good suspension medium which has significant advantages over many other liquids, although other suspending medium may be used in the practice of the present invention. Micronized salmeterol dry powder medicament may be easily suspended in perfluoropentane, and at refrigerated temperatures the perfluoropentanesalmeterol suspensions appear to be stable for several days.
Applicant studied a number of screen materials for use as the carrier screen portions of the medicament carrier cassette, etc. Physio-chemical properties of the screen material which are important include moisture content, abrasion/heat/ chemical resistance, dimensional stability, physical properties of the screen (such as percent open area, air permeability), thread diameter and weave type. Screen samples for use as carrier screen portions were studied including nylon, polyester, polypropylene and stainless steel, and applicant presently believes stainless steel and non-hygroscopic polymers are preferred screen materials since moisture is a problem with many dry powder medicament formulations. Thus, the screen material should be relatively non-hygroscopic and hydrophobic, and this fact decreases the likelihood of nylon and polyester being suitable screen materials. Polypropylene, ethylene tetrafluoroethylene (ETFE) and and ethylene chlorotrifluoro ethylene (E-CTFE) are non-hygroscopic and have excellent hydrophobicities and thus should be suitable screen materials for forming the carrier screen portions of the medicament carriers of the invention.
Although other types of screens may be used as discussed in some detail hereinabove, stainless steel-type screens were used in the testing to be described in more detail below.
Applicant's preliminary statistically designed experiments utilized stainless steel carrier screens and investigated the following factors: mesh count (180, 230, 325; same wire diameter, different percentage open area), drug loading (50 μg and 250 μg), dot size (0.1, 0.15, 0.2 inches), air pulse pressure (2.0, 3.5 and 5.0 atmospheres), air pulse volume (0.1, 0.2 and 0.3 milliliters) and screen configuration (air pulse impacts the drug first --DF, the screen first --SF, and twin screens --TS). Dot size is understood to be the carrier screen diameter.
A 2.5% suspension of fluticasone propionate in perfluoropentane was prepared, and the drug was dispensed or filled onto the screens using an EPPENDORF brand electronic pipette. The particle sizing was accomplished by placing the appropriate screen into the test inhalation dispersing apparatus and firing the dose into an API brand AEROSIZER time-of-flight particle size analyzer.
Summarily, the test results reveal that the best results were obtained by applying the dry powdered medicament to the medicament carrier of the invention using a single screen (no enclosure screens 14 and 16) with high air volume, high air pressure, low drug loading and a small dot size. However, on average the highest particle counts were obtained with a small dot, high drug loading and twin screen configuration.
When the three screen configurations were analyzed separately, applicant discovered that a coarse mesh carrier screen portion worked better for single screen (no enclosure screens 14 and 16) configurations, while a fine mesh performed better for the twin screen (including enclosure screen 14) configuration.
Applicant's analysis performed on only the high air volume/high air pressure measurements confirm the fact that a single screen configuration, low drug loading and a small dot size provided the most favorable particle size distributions, while a twin screen with a high drug loading produced the highest particle counts. Additionally, the fine screen mesh tended to provide higher particle counts on the average.
Applicant's test results from which the aforementioned observations were obtained are set forth in Table 1 and Table 2 below.
TABLE 1______________________________________TESTING RESULTSDRUG LOADING = 40 μgAIR PRESSURE = 70 psigAIR VOLUME = 0.3 mLConfig. MMAD (μM) % <6.3 μm Counts______________________________________DF 2.3 98.5 262734SF 2.5 97.2 342523TS 6.7 49.3 752301______________________________________ NOTE: The results were averaged over screen mesh and dot size
TABLE 2______________________________________TESTING RESULTSDRUG LOADING = 175 μgAIR PRESSURE = 70 psigAIR VOLUME = 0.3 mLConfig. MMAD (μm) % <6.3 μm Counts______________________________________DF 4.0 71.2 1090524SF 3.5 76.2 699456TS 11.4 22.6 1704059______________________________________ NOTE: The results were averaged over screen mesh and dot size
It will be understood that various details of the invention may be changed without departing from the scope of the invention. Furthermore, the foregoing description is for the purpose of illustration only, and not for the purpose of limitation--the invention being defined by the claims.
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PHILADELPHIA - Four faculty members at the University of Pennsylvania have been named Fellows of the American Association for the Advancement of Science. Three from Penn's Perelman School of Medicine and one from its School of Arts and Sciences.
• David Boettiger is emeritus professor of microbiology in the Perelman School of Medicine. He was cited for distinguished contributions to tumor virology and to integrin-mediated cell adhesion, particularly for the identification of adhesion signaling and its regulation by mechanical forces.
• Nancy Bonini, professor of biology in the School of Arts and Sciences and an investigator of the Howard Hughes Medical Institute, was selected for distinguished contributions in the fields of basic and translational neuroscience, particularly as applied to understanding neurodegenerative disorders.
• Nigel Fraser, professor of microbiology in Perelman, was selected as a Fellow for outstanding discoveries about the mechanisms of herpes virus biology, particularly in the area of herpes simplex virus latency and reactivation.
• David Weiner, professor of pathology and laboratory medicine in Perelman, was cited for pioneering and enabling discoveries in the area of DNA vaccines and promoting this nascent field of research.
This year 539 members have been awarded this honor by AAAS because of their scientifically or socially distinguished efforts to advance science or its applications. New Fellows will be honored on Feb. 18 at the AAAS Fellows Forum during the 2012 AAAS Annual Meeting in Vancouver, B.C.


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Create memories & T-Shirts or dub dub music
This great product in black from our department Men and Tank Top category can be printed just for you in the size and style you like. The design Create memories & T-Shirts dub music was created by TATTOOFONT3D and uploaded to Spreadshirt for you to have printed on a Tank Top. Next to a host of other great designs, you can find this Create memories & T-Shirts dub music design in Spreadshirt's Miscellaneous category. If you are interested in topics like dub music or music, then you'll love Create memories & T-Shirts dub music designs by TATTOOFONT3D. Spreadshirt also offers a huge selection of personalised T-shirts, hoodies and accessories for the category Miscellaneous as well as top musica clothing. TATTOOFONT3D's designs have already impressed many of our customers, so we are sure that we've got right stuff for you! Spreadshirt is your shop for great designs of all kinds – whether it's dub music, music or musica. We are sure that you will find something nice in our shop, there are many amazing personalised Miscellaneous T-shirts, jumpers or accessories for you to find! Tags: Design ID: 13561182
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Printers in North-Wales
Business printing
Do you need commercial printing or would you like to find a North-Wales printer who is prepared to help small businesses or new business start ups in the area?
Do your letterheads, business cards, or leaflets need a re-print. Your choice of printer or printing company can make all the difference. If you run a North-Wales business it makes sense to use a North-Wales printer who wants to help and a list of local firms can be found lower down the page. Alternatively, these businesses are also keen to help you:
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Can You Help New Business Start-Ups?
Your information could be here! If you are able to help local small business owners and new business start-ups, we would be delighted to point them in your direction. We are keen to promote one relevant 'new-business friendly' business or organisation in each area as our recommended local partner on an exclusive basis.
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North-Wales Printers
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Billy Ray Cyrus
Singer-songwriter + Actor + Film Producer
Born Aug 25, 1961 Age 54
Hometown City of Flatwoods... Religion Baptist
Height 6' (183 cm) Nationality American
Alma Mater Georgetown College Other Names William Ray
William "Billy" Ray Cyrus is an American country music singer, songwriter, actor and philanthropist, who has achieved great success worldwide. Having released twelve studio albums and forty-four singles since 1992, he is best known for his number one… Read More
View newly released photos of Billy Ray Cyrus.
News + Updates
Browse recent news and stories about Billy Ray Cyrus.
Billy Ray Cyrus Joins Miley In 'taking A Stand' Against Anti Lgbt LawsHuffington Post - Apr 12, 2016
Miley Cyrus And Liam Hemsworth Reunited In Australia This Weekend Vanity FairGoogle News - Jan 03, 2016
Kendall & Kylie Jenner Hit The Town As Mama Jenner Double Dates With Billy Ray CyrusThe Inquisitor - Apr 24, 2015
Horse Line Dances To "Achy Breaky Heart"CBS News - Apr 16, 2015
Learn about the memorable moments in the evolution of Billy Ray Cyrus.
1961 Birth William Ray Cyrus was born on August 25, 1961 in Flatwoods, Kentucky, to Ron Cyrus, a politician and former steelworker, and his wife, the former Ruth Ann Casto. … Read More
1986 24 Years Old From 1986 to 1991, Cyrus was married to Cindy Smith, with whom he co-wrote the songs "Wher'm I Gonna Live?" and "Some Gave All", both of which were featured on his 1992 debut album Some Gave All. On December 28, 1993, Cyrus married Leticia "Tish" Cyrus (née Finley; born May 13, 1967). … Read More
1990 28 Years Old While trying to get a recording contract in Los Angeles, Cyrus suffered many hardships including living in his neighbor's car. However, in 1990, he was signed to PolyGram/Mercury. … Read More
1998 36 Years Old In 1998, Billy Ray Cyrus released his last album for Mercury Records Shot Full of Love. … Read More
2001 39 Years Old … He also had a small part in David Lynch's 2001 film Mulholland Drive as Gene, a pool cleaner who had been having an affair with the wife of Adam Kesher (Justin Theroux). … Read More
2006 44 Years Old He also sang "The Star Spangled Banner" at Game 5 of the 2006 World Series in St. Louis, Missouri.
2008 46 Years Old 2 More Events
The duet of the song debuted at No. 27 on the Country charts and eventually peaked at No. 4 in 2008, giving Billy Ray his first Top 5 single since "Busy Man" in 1999, as well as Miley's first Top 5 on any Billboard chart. … Read More
2009 47 Years Old 1 More Event
On March 14, 2009, the album's title track debuted at No. 59 on the country singles chart and a month later on April 7, Back to Tennessee was released. … Read More
2010 48 Years Old 4 More Events
… He also stated that their single, "Lately", was available on iTunes and that their debut album would be out on August 10, 2010.
2011 49 Years Old However, on March 18, 2011, Cyrus announced on The View that he had dropped the divorce. On June 13, 2013, Tish filed for divorce from Billy Ray after 19 years of marriage, citing irreconcilable differences. However, it was reported in July 2013 that they had gone to couples therapy and rekindled their relationship. … Read More
Original Authors of this text are noted on http://en.wikipedia.org/wiki/Billy_Ray_Cyrus.
Text is made available under the Creative Commons Attribution-ShareAlike License.
Text is made available under the Creative Commons Attribution-ShareAlike License.


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On 10/18/2012 12:50 PM, Laine Stump wrote: > On 10/17/2012 06:30 PM, Eric Blake wrote: >> Previously, snapshot code did its own permission granting (lock >> manager, cgroup device controller, and security manager labeling) >> inline. But now that we are adding block-commit and block-copy >> which also have to change permissions, it's better to reuse >> common code for the task. While snapshot should fall back to >> no access if read-write access failed, block-commit will want to >> fall back to read-only access. The common code doesn't know >> whether failure to grant read-write access should revert to no >> access (snapshot, block-copy) or read-only access (block-commit). >> This code can also be used to revoke access to unused files after >> block-pull. >> > > ACK, with qualifying remarks from the review of the previous version of > the patch (PATCHv2 17/16) I'm adding this to the commit message: It might be nice to clean things up in a future patch by adding new functions to the lock manager, cgroup manager, and security manager that takes a single file name and applies context of a disk to that file, rather than the current semantics of applying context to the entire chain already associated to a disk. That way, we could avoid the games this patch plays of temporarily swapping out the disk->src and related fields of the disk. But that would involve more code changes, so this patch really is the smallest hack for doing the necessary work; besides, this patch is more or less code motion (the hack was already employed by the snapshot creation code, we are just making it reusable). -- Eric Blake eblake redhat com +1-919-301-3266 Libvirt virtualization library http://libvirt.org
Description: OpenPGP digital signature


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Plaka Hotel, Athens
- Free hot/cold buffet breakfast and WiFi
Main amenities
- 67 smoke-free guestrooms
- Restaurant and bar/lounge
- Rooftop terrace
- Spa services
- Airport shuttle
- Childcare
- Terrace
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Free grocery shopping service
What's around
- In Plaka
- Ancient Agora (0.4 mi / 0.6 km)
- Hellenic Parliament (0.5 mi / 0.8 km)
- Acropolis (0.6 mi / 0.9 km)
- Acropolis Museum (0.6 mi / 1 km)
- Panathenaic Stadium (0.9 mi / 1.5 km)
Plaka Hotel, Athens
Hotel Info: 866-539-8117from $97
- Superior Room, Balcony
- Economy Room
- Single Room
- Triple Room
- Triple Room
- Family Room, Connecting Rooms
- Economy
- Single Room
- Deluxe Room (Acropolis View)
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 67 rooms
- This hotel is arranged over 7 floors
- Check-in time 1 PM-9:30 AM
- Check-out time is Noon
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- One child (8 years old and younger) stays free when occupying the parent or guardian's room, using existing bedding
- Babysitting/childcare *
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle (available 24 hours) *
- Train station pickup *
- Cruise terminal shuttle *
- Ferry terminal shuttle *
- No parking
- Discounted offsite parking
- Beach shuttle *
- Shopping center shuttle *
- Theme park shuttle *
Other information
- Smoke-free property
Nearby Three Star Athens hotels
In the hotel
- Free hot/cold buffet breakfast
- Restaurant
- Bar/lounge
- Coffee shop/café
- Room service (during limited hours)
- Coffee/tea in the lobby
- Beach shuttle (surcharge)
- Beach towels
- Pool sun loungers
- Spa services on site
- Playground on site
- Computer station
- 24-hour front desk
- Concierge services
- Tours/ticket assistance
- Dry cleaning/laundry service
- Laundry facilities
- Free grocery shopping service
- Hair salon
- Luggage storage
- Elevator/lift
- ATM/banking
- Safe-deposit box at front desk
- Rooftop terrace
- Terrace
- Television in common areas
In the room
- In-room climate control (air conditioning)
- Air conditioning
- Iron/ironing board (on request)
- Private bathroom
- Free toiletries
- Hair dryer
- Satellite TV channels
- Desk
- Free WiFi
- Refrigerator
- Daily housekeeping
- In-room safe (laptop compatible)
- Connecting/adjoining rooms available
Top Athens hotels
Special features
DiningOnsite venue - restaurant.
Plaka Hotel, Athens's small print
Cash transactions at this property cannot exceed EUR 1500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Noise-free guestrooms cannot be guaranteed.
Only registered guests are allowed in the guestrooms.
For transfers, guests must contact the property 72 hours prior to arrival prior to arrival at the number on the booking confirmation.
Reservations are required for massage services and spa treatments and can be made by contacting the property before arrival at the number on the booking confirmation.
Optional extras
Cribs/Infant beds are available for EUR 5.00 per day
Babysitting/childcare is available for an extra charge
Airport shuttle service is offered for an extra charge of EUR 60 per room (one-way)
Airport shuttle for children between the ages of 0 and 10 costs EUR 41.00 (one-way)
Cruise ship terminal shuttle, ferry terminal shuttle, and train station pick-up service is offered for an extra charge
Beach shuttle, shopping center shuttle, and theme park shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Hotel registry number: 0206K013A0028300
Is the description of this hotel not correct? Tell us


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Depending on my route home, I usually only get onto White Rock Lake's MUP to cross the bridge. Then I'm back on the roadway. Occasionally, I will follow it around and enjoy the lake, before turning off towards the house.
Last night, I stayed on the path and there is a small incline that goes for less than a quarter mile. It's not really steep enough to call it a hill, but it can slow you down a bit.
I was about halfway up this incline, when I herd a voice behind me say, "Don't stop." The sun was just setting behind me so when I looked in my rearview mirror all I could see was the silhouette of a cyclist coming up the little hill.
"Keep going." He says.
I was thinking, "Does it look like I'm having a problem, here? Does he really think that he has to encourage me to stay on my bike?"
His rhythm was a little faster than my cadence, so I picked up the pace to match time with his "coaching." (I was still thinking, "Who is this guy and why does he feel the need to talk me up this little hill?") He was in a higher gear, because even at the same cadence, he was gaining on me.
"Don't stop."
"Keep at it."
I was just topping the slope, when he called out, "On your left!"
Now, I use that shout out so as not to surprise anyone who may be unaware of my presence. If the others already know I'm there, why issue the warning?
I thought, "Well duh! Obviously, I know you're on my left. You just talked me up the hill!"
That's when I looked over and realized he was on a tandem. He wasn't talking to me at all. He was encouraging his stoker.
I suddenly felt rather silly. I gave them both a nod. They are probably still wondering what had me all tickled, as they went by.


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I acquire the following mistake memo when trying to make use of Airdrop. The Apple ID certificate for Richard Fosse is unacceptable. The transfer has been irrecoverable. Both machines iMac and Air has the same ID?
I acquire the following mistake memo when trying to make use of Airdrop. The Apple ID certificate for Richard Fosse is unacceptable. The transfer has been irrecoverable. Both machines iMac and Air has the same ID?
Yes, same trouble for me too. Have had it functioning, nevertheless stopped for no obvious cause, although i had just updated Lion on both Macs to take benefit of the icloud functionality. Friend of mine has suggested relaunching Finder on both machines and even a simple windows style re-boot, but neither worked for me. Really annoying as i use one Mac at home and the other for work, needing to transfer files between the two.
Thought icloud may be the savior in the small term until this difficulty is fixed, nevertheless forcing you to go away through an iOS device when exchanging documents is extreme, particularly docs of significant size, as it takes an iOS device like ipad, an age to process. Why on earth you can't use icloud for docs in a Mac to Mac scenario is beyond me. If Apple saw an opportunity to shift even more i OS devices or iOS software (Pages, Numbers etc) by forcing an iOS device into the equation, then that strikes me as profiteering and short-sighted. I'd have guessed as much of most organizations, but Im disappointed if Apple feel the need for this, given their revenue and unit sales growth.
Is the identical for me, 2 Lions: iMac and Macbook Air.- two dissimilar users logged on the machines : nevertheless the same avatar displayed on the Airdrop windows on the two machines.
- - When I attempt to transmit one file form iMac to Air the system replays: Airdrop certificate.
- - When I attempt to relocate one file from Air to iMac it replays: Transfer refused.
- - No popup panels was displayed in order to ask verification for the transmission
Macbook -> IMAC - When in Macbook pro I attempt to upload a file in air drop it says that Imac declined the transfer. (But I perceptibly I didn't decline nothing. It doesn't ever come into view a confirmation box anymore).
In other posts they said, force quit and prelaunch finder will make it work. But NOT for me. Keeps declining the request. When now I want transfer the IMAC -> Macbook it says the same certificate linked note. And yes. I make use of the similar apple ID on both machines. (Because of the Icloud)
I got the same trouble shooting! Thats really painful and tiring because it worked fine until the last update 10.7.2 with icloud guess all is due to an authentication problem on several machines with the same Apple ID and the certificate.
- Go to System Preferences>System>Users & Groups
- Press "alter" next to the Apple ID
- Enter your password
- Press"-" to remove your apple ID
- Press "Done"
- Press "Set" next to the Apple ID
- Enter you Apple ID and Password and press "OK"
- Remain waited a small number of seconds and then you'll observe the Apple ID on the User & Groups page.
I have tried all these option. I have even been capable to transfer one time. Although never again. The PC do demonstrate up in the airdrop window. Nevertheless when you commence transfer, I acquire the invalid apple id certificate mistake. The merely "attractive" thing I can speak is that I have two Macs nevertheless one apple id.
As far as I know, an Apple ID has nothing to do with it. The two PC communicate with each other and Airdrop creates its individual ad hoc network. So, if yours has only worked once and if you are beneath guarantee, take benefit of it - I'd propose a call to Apple or making an scheduled time at your nearest Genius bar.
Shut both computers down and then restart. Simply closing Finder doesn't appear to accurate this, even though I did not examine this systematically.
Transfer the file as before. HOWEVER, you will have to repeat this complete process every time, including restarting each computer. This actually stinks with any luck Apple will push out a fix today. I plan on visiting an Apple Store today and will request about this matter. Even though, I'm positive they will know much or be able to get the information up the chain.
Works without shutting down, restarting, or opening two Finder windows. Not sure why you need two windows on one machine? save of course you require to go locate the file you want to send - in my case I just put aside it to the desktop and then file it absent later.
That's great! Now it works on my Mac both! Thank you so much! So to fix this trouble, only needs to re-set the iTunes ID on the machines!


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The current population of Surry County is 72,621 with the median age of 42. Surry County's median household income is $35,578, and the average household net worth is $330,541.
|Surry County
|North Carolina
|United States
|Median Household Income
|Average Household Net Worth
|Median Age
|42 years
|37 years
|37 years
Age distribution represents the distribution of the population in Surry County by age group. In Surry County, the male-to-female ratio is 35,478:37,143, which is 0% higher than the ratio of North Carolina, which is 4,876,222:5,126,188. Age demographic data is sourced from census, 2015.
Crime rate index represents the average crime rate for a local area in comparison to nearby areas and the national average. A crime index of 100 represents the national average. North Carolina, has 21% more property crime than the national average, and has 5% less personal crime than the national average
Marital status represents the percent of residents in Surry County that are single, married, widowed and divorced. In Surry County, 77% of people are married and 23% of people are single. The percent of people married is 4% higher than the ratio of North Carolina, which is 72%. Marital data is sourced from census, 2015.
Household income distribution represents the distribution of Surry County income brackets at the household level. Overall, the median household income for Surry County is $35,578, which is 22% lower than that of North Carolina ($45,785). Income data for Surry County is sourced from census, 2015.
Education data represents the highest level of education attained by residents in Surry County. In Surry County, 36% of residents 18 and over graduated from high school and 16% completed a Bachelor's degree or higher, which is 15% lower than that of North Carolina. Education statistics is sourced from census, 2015.


text:
International Speedway Corporation (ISCA)
Industry: Consumer Services
Community Rating:
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International Speedway (ISCA)
Q1 2011 Earnings Call
April 05, 2011 9:00 am ET
Daniel Houser - Chief Financial Officer, Principal Accounting Officer, Senior Vice President and Treasurer
John Saunders - President
Charles Talbert - Director of Investor & Corporate Communications
Lesa Kennedy - Vice Chairman and Chief Executive Officer
Stephen Altebrando - Sidoti & Company, LLC
Michael Walsh
Edward Williams - BMO Capital Markets U.S.
Brandon Taylor - Raymond James
Alvin Concepcion - Citigroup
Barry Lucas - Gabelli & Company, Inc.
Previous Statements by ISCA
» International Speedway CEO discusses Q4 2010 Results - Earnings Call
» International Speedway Corporation F1Q10 (Qtr End 02/28/10) Earnings Call Transcript
» International Speedway Corp. Q4 2009 Earnings Call Transcript
Charles Talbert
Thank you, operator. Good morning, everyone, and welcome to the International Speedway's conference call. We are here to discuss the company's results for the first quarter ended February 28, 2011.
With us on this morning's call are Lesa France Kennedy, Chief Executive Officer; John Saunders, President; and Dan Houser, Senior Vice President and Chief Financial Officer. After our formal remarks, a question-and-answer period will follow. The operator will instruct you on procedures at that time.
Before we start, I would like to address forward-looking statements that may be addressed on the call. Forward-looking statements involve risks, uncertainties and assumptions. Actual future performance, outcomes and results may differ materially from those expressed in these forward-looking statements. Please refer to the documents filed by International Speedway Corporation with the SEC, specifically the most recent reports on Form 10-K and 10-Q, which identify important risk factors, which could cause actual results to differ from those contained in these forward-looking statements.
So with these formalities out of the way, I'll turn the call over to Lesa Kennedy. Lesa?
Lesa Kennedy
Good morning, and thank you for participating in today's call. While we couldn't have asked for a better start to the motorsport season in 2011, in addition to the excitement normally surrounding the start of any season with the anticipation of racing on a freshly paved surface at Daytona, this facility looked fantastic, and the racing has never been better. It was just absolutely fantastic. Our fans loved it.
The capital that we spent on the paving project gave us additional national prominence, as well as providing our fans with a brand new experience. The success of this project confirms our belief that we need to continue our focus on strategic capital opportunities that will enhance the guest experience which, of course, ultimately drive positive results for the company.
The storyline of Trevor Bayne pulling off one of the sport's bigger success to become the youngest driver ever to win the 500 [Daytona 500] provided additional momentum to the start of our season. Trevor is an up and coming driver. He's been a great ambassador to our sport, and he's been featured on national programs such as Good Morning America and Ellen DeGeneres Show. He's only 20 years old, and we expect that he would generate a strong following amongst his age group, which will surely benefit us and NASCAR.
We successfully navigated through an extended downturn in the economy, and remained in excellent financial position. While still early in the year, we remain hopeful that the growth in the economy will continue and lead to job creation. Through prudent cost containment, we expect to see meaningful improvement in our operating margin this year. And as growth returns to the economy and to our sport, these sustained cost savings will provide further margin improvement.
So with that, I'd now like to turn it over to John Saunders. Thank you.
John Saunders
Thank you, Lesa, and good morning, everyone. We are very pleased with the momentum generated from the start of the motorsports season, beginning with Speedweeks at Daytona and then on Phoenix. We had solid attendance, incredible racing and strong television ratings, which contributed to a positive quarter for ISC. Dan will provide a detailed review of our financial performance later in the call.
We're keeping a very close eye on the consumer and corporate spending trends. The economy is improving, but concerns remain, particularly in employment levels, consumer confidence and more recent world events. As a result of being disciplined with our capital structure and having focused attention on the cost side of the business, we are reiterating our full year guidance of total revenues of between $635 million and $650 million and non-GAAP earnings to range between $1.60 and $1.80 per diluted share. This guidance contemplates a strong increase in EPS and operating margins compared to our 2010 results.
Our attendance-related revenues continued to be our most significant short-term business risk. Advanced ticket sales for our Sprint Cup events remain in the range of approximately 11% and 12% off from last year in units and revenue, respectively. While part of this decline is associated with the timing of our renewals and related programs, fans continue to make their purchase decisions closer to race day. This is demonstrated by the strong increase in sales we have seen during the weeks preceding our event. For the Daytona 500, we sold almost 30,000 tickets during the final three weeks before the event. That equates to approximately 20% of the available grandstand capacity at the Speedway.
We understand the challenges that face ISC and are aggressively addressing them. Regaining a more normalized advanced ticket sales trend is a priority. In this operating environment, we are providing our customers with attractive pricing, particularly entry points for new fans. And as always, we maintain price integrity throughout an event sales cycle.
Read the rest of this transcript for free on seekingalpha.com


text:
Timberland 6" Premium Waterproof Boot (Children's)
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Finish Ordering to Complete Your Exchange Request
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1. Request an Exchange
2. Select a Replacement
3. Review and Finalize
We're sorry — no color of this style is currently available.
Brand: Timberland
Style: 6" Premium Waterproof Boot
To email a friend about the 6" Premium Waterproof Boot, click here
To be notified when the 6" Premium Waterproof Boot is available in your size, click here
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text:
Business Description
R A Myers Construction provides Additions and Remodels services in Muncie, IN. Call them at 765-896-9704 for more details.
Reviews0Write a Review
No reviews yet, be the first to submit a review
Featured Contractors
"Mike, George and his team overhauled my house - replacing the existing siding with hardie-plank lap siding, replaced the roof, installed new cedar tr..." - Justin G
"1. Was the contractor timely during the course of the job? Yes. They worked into the evening since they knew a storm was coming and they wanted to m..." - Peggy L
"Jeff tore out our blocks from under our house and poured new footers. They laid new block It looks good. " - gary w


text:
usedverbuk /juːst/ us /juːst/
More examples
usedadjectiveuk /juːst/ /juːzd/ us /juːst/ /juːzd/
used adjective (FAMILIAR)
More examples
- She's used to dealing with difficult customers.
- After a while you get used to all the noise.
- I'm so used to living alone now, I don't think I would like sharing with anyone again.
- I'm not used to driving an automatic car - I keep trying to change gear!
- Dad was used to being in charge and it was difficult for him to take orders from anyone.
used adjective (NOT NEW)


text:
Changes related to "Self-Actualization FM"
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold.
2 May 2016
- (diff | his) . . Radio Del Mundo; 15:53 . . (+202) . . Christophee (talk | contribs) (Taken from the credits at the end of the game)


text:
Joel Ruml, chair of the Czech Ecumenical Council, welcomed a draft settlement that allows churches in the Czech Republic to reclaim buildings and land seized under communist rule.
Ownership of those church properties, seized in the 1940s and 1950s, has been disputed since the 1989 Velvet Revolution ended communist rule.
Ruml said official legislation is expected to come early next year, with restitution beginning as soon as January 2013.
The settlement agreement also means churches would have to give up subsidies in a country where the state has paid clergy salaries since the 18th century.
© 2016 Augsburg Fortress, Publishers


text:
Have you checked everything off your Oscar to-do list? With the Academy Awards rolling out the red carpet on Sunday, if you're caught up, this weekend is a good time to catch a grab bag of films ranging from the tiniest of indies to an escapist actioner. The must-to-avoid is Fox's hack Christ Movie, which looks like it's made from outtakes from TV's "The Bible"--it's from the same producing team. If you want to see what smart filmmakers can do with the Jesus story, watch Mel Gibson's "The Passion of the Christ" or Martin Scorsese's "The Last Temptation of Christ" instead.
Trailers below.
Ritesh Batra's feature debut, the unprepossessing indie "The Lunchbox," has heart. Set in and around Mumbai's grand-scale lunchbox delivery system, the warm, well-observed romantic drama was snapped up by Sony Pictures Classics out of Cannes, where it won the viewer's choice award at Critics' Week. India unaccountably overlooked the indie word-of-mouth hit of Telluride and Toronto as its Oscar submission.
From the directors of "A Town Called Panic," the animated "Ernest and Celestine" is a delightfully weird and gentle mix of comedy and tenderness in its story of the unlikely friendship between a mouse and a bear. Oscar-nominated for Best Animated Feature -- though it doesn't hold a candle to "Frozen" in terms of awards chances -- the French animated farce has now been revamped with a star English-language voice cast featuring Forest Whitaker, Megan Mullally, Nick Offerman and Paul Giamatti.
Liam Neeson once again proves his fortitude as one of our biggest action stars in "Non-Stop," an airborne paranoid thriller costarring Julianne Moore and "House of Cards"' Corey Stoll. Critics have reacted favorably to this film, as they have done to the "Taken" films and 2011's under-appreciated "The Grey." Neeson tends to be a box office draw, so "Non-Stop" should play well this weekend--especially for those of us in need of respite from all this Oscar season ballyhoo, hitting its apogee this Sunday evening.
The Lunchbox Dir. Ritesh Batra, India | Sony Pictures Classics | Cast: Irrfan Khan, Nimrat Kaur, Nawazuddin Siddiqui, Lillete Dubey | 94% Fresh | NYT: "The comedy is more wry than uproarious, the melodrama gently poignant rather than operatic, and the sentimentality just sweet enough to be satisfying rather than bothersome." Our review and roundup
Ernest & Celestine Dirs. Stephane Aubier, Vincent Patar & Benjamin Renner, France | GKIDS | Voice cast: Forest Whitaker, Mackenzie Foy, Lauren Bacall, Paul Giamatti, William H. Macy, Megan Mullally, Nick Offerman, Jeffrey Wright | 100% Fresh | LA Weekly: "The film's gorgeous, hand-drawn animation is as lovingly detailed as the drawings a girl mouse named Celestine is secretly making about an imaginary mouse and bear friendship." | Our review
Non-Stop Dir. Jaume Collet-Serra, USA | Universal Pictures | Cast: Liam Neeson, Julianne Moore, Scoot McNairy, Nate Parker, Corey Stoll | 57% Fresh | Washington Post: "It's the propulsive pace of the film and the nice sense of suspense it builds that help most in glossing over its failings."
Son of God Dir. Christopher Spencer, USA | 20th Century Fox | Cast: Diogo Morgado, Roma Downey, Greg Hicks, Adrian Schiller, Darwin Shaw, Sebastian Knapp | 27% Fresh | Film.com: "Considering just how popular Jesus is, you'd think he'd get better treatment." | Our interview with Morgado


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FaithWeaver Friends Elementary Service to Jesus Key (pkg. 5)Group
For completion of a service project. These exciting, collectable tokens are a "key" component of a successful FaithWeaver Friends program. These unique "keys" serve as unforgettable celebrations and reminders of spiritual growth, service and participation...for both students... Read More
More From: Group
- Store Only: Yes
- Product type: Curriculum
- Format: Keys (Pack of 5)
- Release Date: Jul 18, 2005
- Height: 0
- Width: 0
- Length: 0


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I am building a new house which is very contemporary in look. in the bedrooms we are putting in baseboard heating but all of the units are bigger and uglier than i want. does anyone know a manufacturer of more modern sleek design units?
- Forum >
- Miscellaneous >
- low profile baseboard heating
I have actually never seen a "Lo Profile baseboard". The size that you see accomendates the copper pipe as well as the brackets to hold it in place......I think you may be asking for something that does not exist.....
[This message has been edited by HOLLYWOOD (edited July 21, 2000).]
Waite for other reply's, maybe someone else can help...
[This message has been edited by HOLLYWOOD (edited July 21, 2000).]
- 15 Old House Features We Shouldn't Abandon
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Honors senior Madelynn Archer's original fashion designs were accepted this month for the juried... Read More
Assistant Professor of Fashion Merchandising and Design Eunyoung Yang earned first place in a juried... Read More
Students participating in Meredith College's 2013 study abroad program in Paris have all been... Read More
Meredith College has made the 2015 list of top fashion merchandising programs at private schools in... Read More
Cori Spade, '13, a recent graduate of Meredith's fashion program, has been selected... Read More
Meredith College student Alanna Ryder was able to make connections in the fashion industry as... Read More
Cori Spade, '13, a recent graduate of Meredith's fashion program, brought her designs... Read More
Alumna Amanda Schardt, '05, returned to Meredith College to talk about her work in the... Read More
A strong student has a plan. For Jennifer Coples, '16, her plan has included taking advantage of every opportunity that came her way –...more
Honors student. Undergraduate researcher. Member of various clubs and organizations. These are just a few roles Avonee Simmons, '17, has played during her three years...more
Meredith College was the right fit Rachel Didier, '15, from the beginning.
One of the fashion merchandising major's favorite memories is...more
Fashion major Melissa de Leon knows her Meredith education will never go out of style.
"Meredith has taught me how to be independent, self-motivated,...more
201 Martin Hall
(919) 760-8395


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Still Black Still Proud: The African Tribute to James Brown
The Godfather of Soul was not only a hugely influential icon in the U.S. and Europe, he was perhaps even more revered in Africa, where enthusiastic throngs turned out for his concerts in the late '60s and early '70s (including one preceding Zaire's Muhammad Ali-George Foreman "Rumble in the Jungle"). The roots of Brown's funk were African, of course, but he also had a profound effect on a generation of African musicians, such as Afrobeat instigator Fela Kuti. What goes around has come around yet again with this phenomenal tribute to Brown from some of his key collaborators and luminaries of contemporary African music. The band will be led by saxophonist and former Brown musical director Pee Wee Ellis. He'll be joined by his fellow JB Horn mate trombonist Fred Wesley Jr., a funk icon himself, plus singers Martha High (who sang with Brown for 30 years), and Fred Ross (who has toured with Ellis and Wesley). The African contingent will include guitarist and singer Vieux Farka Touré (who has picked up the style and genius of his late, renowned father Ali Farka Touré), Senegalese singer/guitarist Cheikh Lô (a protégé of Youssou N'Dour who taps myriad pan-African and world music influences), and Senegalese master percussionist Papa Assane M'Baye. Among notables in the supporting band is veteran soul/R&B guitarist Reggie Ward. This show earned rave reviews in Europe before coming stateside. The Dakota date is sandwiched between stops at Lincoln Center and the Chicago Jazz Festival, and promises to be utterly unique and unforgettable. $60 at 7 p.m.; $45 at 9:30 p.m.
Sun., Aug. 24, 2008
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Little, old House near Zurich: Maur au Lac
Size45 m²
Floor No.
- Family/child friendly
- Kitchen
- Parking available
- Pets allowed
- Internet/WiFi
- Lockable room
- Towels
|Kehlhofstrasse, 8124 Maur, Switzerland
|Property type
|Chalet or cabin
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
|3 weeks ago
In Maur near Zürich we have a small old house with two rooms. This house needs to be rebuilt very soon. This 120 year old house is very basic and please note that it is worn out. On the ground floor it has a small kitchen and upstairs there is a toilet and a shower.
Before booking we would like if you could introduce yourself quickley, so that we can imagine to what kind of persons we are going to rent this little house, Please do only write words, If you write numbers, mailadresses, websites, then Wimdu will not deliver the message, or shorten it.
No smoking inside. Because we never smoke, we prefer guest who do not even know what tobacco is. Some people went for a walk well away from the house whenever they had to smoke, and that was ok for us.
Some people have said that the house is smelling and that is is not healthy to live there. So the time is really coming that the house has to be rebuilt. But other people did not have this impression.
Since all the cats in the neighbouhood do only have psychologic tasks it can happen that we meet a mouse in the kitchen.
The house is heated with electric heaters and if it is very cold outside then it will not be very warm inside. Therefore it may be advisable not to book to early in winter and watch the weather conditions first.
The house is not everybodys style, but many artists and creative people have stayed here and felt quite well.
We think this little hous is ok until max 4 persons. A dog we count like an extra person.
Our guest often do not find the forks and knives. They are in the drawer of the table in the room.
Maur is still a farming village, 35 minutes by tram and bus from the main train station of Zurich (12km east, at a lake opposite of Uster)
Local attractions
- pretty village with 4 restaurants and small castle of XII century
- 5 minute walk through the fields to the lake, or 4 hours around it
- free Internet access at PC in room and open wireless (if it works)
- bicycles have to be repaired first
Do only come if you have made a reservation!
Do not come with an expensive car. It does not suit with the house.
How to get there by public transport:
- a ticket (enter 8124 at machine) costs Fr.8.20 (valid 2 hours),
or an pass for 24 hours (Zones 10, 21,30) costs Fr.16.40
(Train rides to the airport are included in those tickets. If you buy a card with 6 tickets on it, you can buy half fare if you are not over 25 years old. A monthly all zones pass valid after 9am, personal or transferable, costs about SFr.120.-.)
- tram number 3 to Klusplatz (allow 20 minutes to get there)
- then bus 747, leaves at about 19 and 49 past every hour, last bus at 36 minutes past midnight, 20 min. ride via Witikon, Binz, Ebmatingen to Maur Dorf (at the foot of the hill).
From the Airport Tram 12 to Stettbach and then bus 743 to Maur Dorf. This works until about 8pm. Later Stettbach to Fällanden then bus to Pfaffhausen then bus 747 to Maur Dorf. Or right away but more expensive from the Airport train to Zurich main station, tram 3 to Klusplatz (final stop), bus 747 to Maur Dorf.
- Do not smoke in the house.
- Pets by arrangement.
You will find clean towels and sheets, but they are not ironed.
- The fee of CHF 30 for fresh linnen you have to pay separately at the end of your stay. If you leave the house very clean then we will not insist on this payment.
Please do not feed the cats and do also not give them any milk! They get enough to eat in their homes and our neighbours are very sad when their cats do not come home anymore.
|Weekly rate for up to 2 guests
|Price for > 2 guests
|$ 13 US per guest/night extra
|Maximum nights
|2 weeks
|Check-in after
|On arrangement
|Check-in before
|On arrangement
|Check-out before
|On arrangement
|Cancellation Policy
The attic is really very simple, but brilliant to the position. Immediately on the subway, on the sea, the Gothic Quarter, what more could you want. In Calle Ferran, you get everything, even bread on Sunday morning. And the view from the roof terrace (to the Sagrada Familia, Tibidabo, Montjuic and sea) is fantastic. Especially when you can sit outside, it is gorgeous. Since we had at Easter a little fresh air, 4 chairs inside would not have been bad. But the plastic chairs outside of it did then and for this one time
Die Dachwohnung ist wirklich sehr einfach, aber von der Lage her brilliant. Sofort an der U-Bahn, am Meer, im Barrio Gotico, was will man mehr. In der Calle Ferran bekommt man alles, auch Brötchen am Sonntag Morgen. Und der Blick von der Dachterrasse (bis zur Sagrada Familia, Tibidabo, Montjuic und Meer) ist fantastisch. Vor allem, wenn man draußen sitzen kann, ist es traumhaft. Da wir an Ostern ein wenig frischen Wind hatten, wären 4 Stühle im Innern nicht schlecht gewesen. Aber die Plastikstühle von draußen taten es dann auch für dieses eine Mal.
The apartment is great and the roof terrace was a dream! Perfect for two people if you do not have high standards of luxury, there is everything you need for a great holiday, and the transfer went smoothly with the neighbor!
Die Wohnung ist super und die Dachterrasse ein Traum! Perfekt für zwei Personen, wenn man keine hohen Ansprüche an Luxus hat, es gibt alles was man für einen tollen Urlaub braucht, und auch die Übergabe mit der Nachbarin verlief reibungslos!
The flat-beschrieben.Gutes just how much value for money. Great roof terrace, great location, right in the center. Keys has also worked for eight mid-Thank you perfectly. The bed was not as comfortable.
Die Wohnung sehr einfach-wie beschrieben.Gutes Preis-Leistungsverhältnis. Tolle Dachterasse, super Lage-mitten im Zentrum .Schlüsselübergabe hat auch nach Mittenacht perfekt geklappt-Danke.
Das Bett war nicht so bequem.
All perfecto.Gracias for their hospitality
Todo perfecto.Gracias por su hospitalidad
Everything is pretty well described in the offer and then the information received: a small apartment without comfort or maintenance surperflu but with a nice terrace (shared with other residents of the building, not private) and a very quiet room so that it is in the center (of as much as our neighbors were quiet too) We were frankly pleased with the value for money :-)
Tout est plutot bien décrit dans l offre et puis dans les informations reçues: un petit appartement sans confort ni entretien surperflu mais avec une belle terrasse (partagée avec les autres habitants de l immeuble, donc pas privée) et une chambre très calme alors qu'il est en plein centre ( d autant que nos voisines étaient calmes aussi) Nous étions franchement contents du rapport qualité-prix :-)
Very old farmhouse however the atmosphere was very comforting and a great place to spend a peaceful few nights.
Really great and lovely hosts. A really nice old farmhouse like the description. That was certainly not my last time I was here. Five out of five stars. Great!
Wirklich tolle und nette Gastgeber. Ein richtig schönes altes Bauernhaus, wie auf der Beschreibung. Das war sicher nicht mein letztes Mal, dass ich hier war. Fünf von fünf Sternen. Toll!
Very nice apartment with a terrace overlooking a magnificent view of Barcelona. It would be foolish to refuse to rent because many steps!
Très bel appartement avec une terrasse donnant sur une vue magnifique de Barcelone. Il faudrait être fou de refuser de louer à cause des marches nombreuses !
Pleasant, perched on the terraces in the center of Barcelona.
Séjour agréable, perché sur les terrasses du centre de Barcelone.
This place is really in the middel of everything. Surprisingly quiet considering the location.
Very basic but sufficiently.
Beatuiful afternoon sun on the terrace, perfect for a cold beer at 5 pm. If you open the window in the bathroom while showering you can shower in the sun :-)
You have to like climbing stairs.
- Quality assured accommodation
- Every host is verified by telephone
- Secure payment via SSL encryption


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Any suggestions for faster and safer cornering for road (asphalt)? Although, with an increase in speed, of course, the safety factor declines. Also, would tire pressure affect cornering as well? For example, would one be able to corner faster and safer at 100psi instead of 120psi? Particularly, would the lower pressure allow the tire to flex more, and therefore stick more of its tread on the pavement?
The psychological factor is an obstacle for me as well, because few years ago, when I just started getting back into cycling after a 20-year hiatus, I fractured my left elbow into three pieces and broke my left hip, which were not from cornering; however, the fall has affected my confidence in the techniques for riding faster. Intellectually, I know the cornering techniques. 20 years ago I was even able to push the bike more to the ground, put massive pressure on the opposite pedal and keep my upper body more upright (or leaning less than the bike). I seem to have lost my edge due to age and I hope to race again, but of course this will not happen unless I get some decent bike handling skills back.


text: My PC became suddenly very slow, and then I thought of checking Task Manager. Sure enough, I found REALPLAY.EXE using lots of CPU power and yet no real player app. open. I then searched for that .EXE file on my drive C and Windows could not find it. Is this a hoax? It always scares me when I see a background program taking a third of my CPU for no apparent reason. According to me, if it were a legitimate background program looking to see if there is an upgrade; it would take 2% of the CPU, not 35%.


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As of today, a month before the November election, I'd bet Mike McGinn is going to be the next mayor of Seattle. And Susan Hutchison is going to be the next King County executive.
As of today, a month before the November election, I'd bet Mike McGinn is going to be the next mayor of Seattle.
And Susan Hutchison is going to be the next King County executive.
Why that odd couple?
Because it feels like a Tim Eyman kind of year.
- Seattle-area home prices set record; 2nd-fastest rising in nation
- Students seeking sugar daddies for tuition, rent
- Florida man runs over couple on motorcycle during road-rage incident
- The best deli in Seattle that you've probably never heard of
- South Florida officers find 2 alligators eating human body
Most Read Stories
Say what? Before you go pointing out the ways McGinn (a greenie liberal lawyer) and Hutchison (a sort-of-Republican former newscaster) have absolutely nothing in common with one another, let alone with Eyman (an anti-tax initiative mercenary), there is one key way their stars are aligning this year.
They are the anti-establishment. At a time when the old-guard power structure is about as popular as a swine-flu sneeze (see Nickels, Greg).
You can see the surly mood in a new poll on Eyman's latest: His government-limiting Initiative 1033 is ahead by a whopping 30 points, 61 to 31 percent.
My hunch isn't that voters think Eyman has stumbled on a brilliant idea (think the blind squirrel finding an acorn). It's that Eyman's longtime foil — government — seems tone-deaf right now to people across the political spectrum.
Enter McGinn.
"If you want a mayor who's going to go along with the same big businesses and unions that have set the agenda in Seattle for a long time, then I'm not your man," McGinn told me.
I watched McGinn as he went before The Seattle Times editorial board last week and proceeded to disagree with the establishment position about most everything.
He's not easily pigeonholed. Is he a liberal? Well, yes. But when he's indicting the shaky financing of the $4.2 billion waterfront-tunnel project you could be listening to … Tim Eyman!
"The tunnel's going to be the largest tax increase in Seattle history," he says, "and that's before the cost overruns. Shouldn't they let us at least vote on that?"
So both the business and labor establishments are rallying around McGinn's opponent, Joe Mallahan. The outsider status Mallahan once had now is blurred in a blizzard of checks from the insiders.
McGinn says he's no obstructionist. Except when government tries to foist stuff on people they don't want.
Such as the tunnel. Or that big roads and transit package in 2007. McGinn led the campaign to defeat that, then helped put just the transit portion back on the ballot. It won overwhelmingly.
"That isn't a record of obstruction, that is listening to what the public wants and then making it happen," McGinn argues.
McGinn is on to something. I'm opposed to a tunnel vote myself, as Seattle already seems bogged down in too much talking and not enough doing. But cynicism about government right now is epic. People see it as catering to narrow special interests.
So McGinn is offering a kind of lefty version of Eyman's populist pact. Go around the old power structure. Go straight to the public with your ideas. Or go the way of Greg Nickels.
Now over in the King County executive's race, there's no official Democrat vs. Republican anymore. But there is outsider vs. insider — a theme that's killing the insider, King County Councilmember Dow Constantine.
He's far more experienced and knowledgeable about the county's problems than Hutchison. Which she uses as a cudgel, asking: Well, then why haven't you solved them?
It's a good question he hasn't answered. Often his campaign changes the subject like this: Yeah, so. But you're a pro-lifer!
I don't think that's going to work. Hutchison probably is anti-abortion — she won't say, which is lame — but she's no right-winger. She supports domestic partnerships for gays and lesbians, Referendum 71. She backs putting a levy on the ballot for social services (which actually puts her to the left of Constantine).
And she opposes Eyman's initiative, saying it would be "a disaster."
Everyone's against Eyman, as usual. But it sure seems like his spirit is dominating the debate.
Danny Westneat's column appears Wednesday and Sunday. Reach him at 206-464-2086 or firstname.lastname@example.com.


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The Dahlonega Literary Festival is an annual celebration of books that takes place in March. Situated in Historic Downtown Dahlonega, the festival continues to grow and become more delightful as the years go on. Ours is an intimate festival about books and authors with a mission to promote interaction between readers and writers in a relaxed, informal environment. Visitors have an opportunity to meet and interact with the authors. In addition to attending speaking events and book signings, attendees can have lunch with their favorite authors at a local restaurant.
Past featured authors include: Frances Mayes, Diana Gabaldon, Terry Kay, Deanna Raybourn, Joshilyn Jackson, and many more. Where else can you see, have conversations with, and even dine with bestselling authors while surrounded by the beautiful North Georgia Mountains.
We promise that it will interest anyone who is a lover of books and reading. All festival events are free and open to the public unless otherwise noted.
Dahlonega Literary Festival operates under the 501c3 umbrella of the Lumpkin County Literacy Coalition. Please visit our Sponsorship page if you are interested in donating to our festival.
* * *
2016 Festival Steering Committee
Chair: Arienne Wallace
Regional Writers Committee Chair: Ken Smoke
Financial Committee Chair: David Rumsch
Bookkeeper: Sue Neil
Author Selection Committee Chair: Carol Malcolm
Publicity Co-Chairs: Julie Smith (News Releases & Media Requests) and April Loebick (Website & Social Media)
Scheduling Committee Chair: Carol Malcolm
Facilities/Events Committee Chair: OPEN
Sponsorships/Fundraising Committee Chair: Jeremy Logan


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honda activa parts catalogue
Honda Activa-i
Honda Activa-i is powered by an engine with a displacement of 109.2 CC. Its maximum power is 8.1PS. The dimensions of the motorcycle are 1795 x 705 x 1115 mm (length X width X height). The bike's seat height or the ground clearance is 165. ... read more
Honda Activa 125
Honda Activa 125's engine displacement is 124.9 CC. Its engine generates a maximum power of 8.7PS. The exterior dimensions of the bike are 1814 x 704 x 1151 mm (length X width X height) while its ground clearance is 155. ... read more
Did you mean?
New Cars
Honda Brio
The Brio was launched in September 2011. It is a radical looking small car that brings good looks to the masses! The front has a slightly cab forward design and the bonnet is pretty small. It wears the family logo rather proudly in a heavily chromed horizontal grille. There is a strong crease runnin ... read more
Honda City
The 4th generation Honda City has taken the game up a notch over its popular predecessor and for the segment as a whole. While the length and width of the car remain the same as the third generation model the new City is 40mm taller and the wheelbase has gone up by 50mm compared to the outgoing mode ... read more
Used Cars
Honda City ZX GXi (2004)
new paint, new parts, alloy wheels,, ... read more
|Registration no: wb02r
|Colour: Gold
|City: Kolkata
|Asking Price: 3,00,000
Toyota Corolla H3 1.8G (2006)
Excellent car condition with all the parts working in excellent condition, ... read more
|Registration no: AP 11 AA 8484
|Colour: White
|City: Hyderabad
|Asking Price: 2,80,000
Upcoming Cars
Honda BR-V
The Honda BR-V is a seven-seater compact-SUV that will be launched in India sometime in 2016 ... read more
Honda Vezel
At first glance, it has to be said that the new Honda Vezel compact SUV is quite the looker with its bold design cues that mimic the front end of its ... read more
User Reviews
Maruti Ritz 2008-2012 Reviews
Guys, I received my RITZ VXI Baker's chocolate recently after waiting of almost 2 months. Its owesome car. Its very spacious with good head room. Enough room for three persons in the back seat, which I didnot find in any other car in this segment except Indica. I dont like white,silver and Blue coloread more
Skoda Laura Reviews
I bought this car around 3 months back. During the first week, I really loved this car. But then suddenly after the very first week, the cooling dropped to zero. So I went to the skoda service centre. It took them 2 days to figure out whats wrong with the car. After that they gave me a shocking newsread more
Honda Motorcycle & Scooter India Pvt. Ltd. (HMSI) at the Auto Expo 2014 launched its first 125cc scooter, the Activa 125 and now the manufacturer Read more detail
The automatic scooter segment in Indian two-wheeler market is growing rapidly. The companies, such as Yamaha has recently launched its male oriented Read more detail
Expert Reviews
Honda Discover Amazing India : Rann of Kutch drive
Honda has been running its Discover Amazing India drive initiative for a while now. Under this banner, Honda hosts drives in different parts of the read more
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��What car is that? Haven't seen it in these parts before. Petrol or diesel? How much does it cost?" The questions came one after the other in quick su read more
Honda Activa 125 Unveil
2014 Auto Expo: Honda unveiled the 125 cc Activa ...view video
Honda Activa - i Launch : Turbo 44
Honda launched the new Activa-i compact scooter for the young professional and targeting the female buyer. Same as the Activa technically, the Activa ...view video
Forum Discussions
octroi charges in mumbai
how much is the octroi charges and the related registration charges for honda activa being shifted from indore to mumbai
honda activa
I want the latest honda activa in white colour. can you please send me the details of finance about this activa because i cannot pay the full payment asap I want to buy this by tomorrow
New Car Dealers
Lally Motors Ltd. ( Honda)
G.T Road, Sultanwind, Sultanwind
Phone: 0183-3067777
Aditya Car Automotive Pvt. Ltd. ( Honda)
N.H.5 Rudrapur - 752101 , Rudrapur
Phone: 0674 - 2463597
Phone: 0674 - 3091128
Used Car Dealers
Shree Jay Ambe Auto Point
1 Urja Complex, Opp Mahadev Temple, Nr Visat Petrol Pump, Sabarmati, Ahmedabad - 380005Ahmedabad, Sabarmati
Phone: 079-32525889
Mobile: 0-9898690836
Dakshin Honda(Elite automobiles Pvt. Ltd.)
97/1A, Singhasandra Village, Hosur Road, Bangalore-560068Bangalore, Hosur Road