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Chelsea Adams - 4/7 - Bruce Clay, Inc. Blog
Chelsea Adams is a long-distance cyclist, aspiring cob house builder, schema/analytics/algorithm obsessor and senior content writer at Bruce Clay, Inc. Chelsea would love to be stuck on an island with Avinash Kaushik, Ben Folds, Geoff Lawton and the world's largest Apples to Apples deck.
Posts by Chelsea Adams
January 23, 2014
Google is Not Currently Considering Social Signals, But Change Could Be On the Horizon
"Are Facebook and Twitter signals part of the ranking algorithm?" According to a Google Webmaster Help video Matt Cutts released yesterday, the answer is a very definitive no (for right now).
Learn what Cutts has to say about social signals and their affect on ranking in 2014, correlation versus causation, and how the future of Web identity could very well change everything.
Read Google is Not Currently Considering Social Signals, But Change Could Be On the Horizon.
January 20, 2014
5 Ways to Leverage the "Always-On Google Zeitgeist" – Google Trends
Google calls Trends an "always-on Google zeitgeist." Usually when a brand uses a grandiose word like zeitgeist to describe itself I can't resist an eye roll. In this case I did something more like an eyebrow roll as it struck me like an epiphany how spot-on the word "zeitgeist" is to describe the Trends tool.
Learn more about why you should consider Google Trends much more than just a state-by-state LeBron James peak interest analyzer in 5 Ways to Leverage the "Always-On Google Zeitgeist" – Google Trends.
January 9, 2014
Why J.D. Salinger Doesn't Need Keyword Research, But You Do
J.D. Salinger didn't care if people read what he wrote; he didn't care if his writing was relevant to his audience's needs, or if it solved their problems; he didn't want you to easily find what he'd written. For all these reasons J.D. Salinger does not need keyword research.
J.D. Salinger could pull ideas from the sky and write about whatever he wanted because he wrote for himself and his safe and the wants and wishes of his reader didn't affect his bottom line.
Now, you on the other hand. If you're reading this blog you probably do care whether people read your content. You understand that creating content no one reads is a drag. And, actually, aside from plain hurting your soul, you understand that content that goes unread is also a huge waste of time and money.
For content creators looking to create relevant content that gets in front of the right audience at the right time the information yielding from keyword research should be considered pure marketing-strategy gold.
Read on for why "Strings Not Things" makes keyword research more important, not less in Why J.D. Salinger Doesn't Need Keyword Research, But You Do.
January 3, 2014
10 Ways to Make Your Content Marketing Strategy Work Harder For You In The New Year [PDF]
SEO isn't dead and content marketing isn't a fad. In fact, today 9 in 10 organizations market with content, and 78% of marketers believe custom branded content will become more important in the next year. With "the next year" being now. 2014. Is your content marketing strategy ready for 2014? Below is a 10-step kick-start list […]
December 18, 2013
How to Find Niche Influencers in Google+, Twitter and the World at Large
In a recent Google+ article I mentioned that it is a good idea to work on engaging your niche influencers in hopes of them, someday, engaging you back or sharing your content with their audience.
In response to this last part, I received an excellent question in the comments section:
"We would love to reach out and engage with our niches Google+ 'thought leaders' but we don't know how to go about finding them. The best we can do is other companies engaged in our business but since they are competitors, they don't quite fit the bill. Do you have any thoughts or advice on how one can accomplish this?"
Talk about putting the cart before the horse, Adams! How can you engage influencers if you don't know who your influencers are?
I love this question. I loved it then, and I love it now.
Here's a spruced up recap of what I told Ken from North Carolina.
Read How to Find Niche Influencers in Google+, Twitter and the World at Large.
December 16, 2013
Christmas Content Marketing Book Giveaway
The countdown to Christmas has begun and co-authors Bruce Clay and Murray Newlands are getting in the spirit by giving away a copy of their new content marketing book Content Marketing Strategies for Professionals every day from December 16 through December 25, 2013.
The giveaway launched Friday 12/13 on the Bruce Clay, Inc. Facebook page and will reward a new Facebook fan with a book every day for 10 consecutive days. There is no purchase necessary to enter.
To enter the book giveaway visit the Holiday Book Giveaway app at Facebook.com/BruceClayInc.
December 10, 2013
3 Client Communication Tactics That Keep Everyone on the Same Page
A couple weeks ago I found myself in a Twitter chat (#SEOChat) discussing amongst my peers SEO mistakes and the lessons we've taken away from our wrong turns.
As it turns out, the SEOs in the chat didn't need a bunch of different solutions to solve a bunch of different problems; they just needed one common solution — improved communication
Here are three communication tactics we implement at Bruce Clay, Inc. that you might find easy to apply and useful in your own work.
Read more of 3 Client Communication Tactics That Keep Everyone on the Same Page.
November 14, 2013
How Ray Ban is Using Music, Architecture and the Human Experience to Sell Sunglasses
I love when I come across a utilitarian brand like Ray Ban who, despite selling a product that doesn't naturally lend itself to content creation (who wants to read dozens of articles about sunglasses?), has a content marketing strategy that is engaging, memorable, and, more or less, killing it.
Ray Ban LogoThe trick? Excellent storytelling that aligns the brand with the target market's deeper interests. Or — in Ray Ban's case — using music, architecture and the human experience to sell sunglasses.
Read on for two takeaways from Ray Ban's content marketing strategy that we can all learn from.
November 8, 2013
2013 SEMPO Salary Survey Results Now Available
After nine months of data collection, the SEMPO and ClickZ 2013 Salary Survey results are in. An annual endeavor, the 20-question survey asked 2,180 in-house and agency digital marketers to discuss their careers including questions on background experience, salary, responsibilities, internal policies, budgets, and compensation perks.
SEMPO Salary Survey Results CoverThe data collected — which is presented in a series of bar graphs, pie charts, and word clusters accompanied by summary text — gives employers and employees a tangible way to answer these two questions: "What's the health and landscape of my industry?" and "how to do I fare against the competition?"
Read more of 2013 SEMPO Salary Survey Results Now Available.
November 7, 2013
6 Reasons You Should Take the SEMPO State of Search Survey
"Would you like to take this survey?"
If you're asking me from outside of Whole Foods: No.
If you're @SEMPOGlobal and it's the annual State of Search survey: Yes!
The State of Search survey is open to anyone who considers themselves a digital marketer (no SEMPO membership required) from now through November 15, 2013. I took it and you should too. To take the survey, head to SEMPO.org to participate in the re-envisioned 2013 State of Search survey.
If you need convincing, here are five reasons why I always participate in the State of Search survey, and why you might consider participating this year.


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Your favorite music genre!
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December 21st, 2012 (2:15 PM).
Sassy Milkshake
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I don't have a favorite genre per se, but there are those that I prefer over others. Pop music and indie music are two that I like. A lot of stuff these days seems like a mix between the two which I like. Rock and most of its sublevels aren't so bad either.
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The Savage & Beautiful Country (ebook)
by Sukey Parnell, SukeyP
Sukey Parnell's highly personal photographic account of her last days with her mother.
Category: Biographies & Memoirs
About the Creator
Sukey Parnell , SukeyP
London, UK
"Working primarily as a portraitist, Parnell turned to photography whilst navigating her entry into 'midlife', which was accompanied by the birth of her son and the death at home of her mother. Her work has sprung out of a desire to reveal the hidden psychic transitions that accompany female middle and older age and the attendant change in relation of the individual to their mortality and the gaze of society. Pete Smith, Senior Lecturer, TVU Private commissions include a library of portrait images for Brit comedian, Bill Bailey and up and coming recording artist, Antigone. Her work has appeared in publications such as the Independent on Sunday, the Radio Times and a recent cover and feature on Dame Joan Bakewell in Saga magazine. She has won various awards including being a finalist twice in the prestigious Photographic Prize at the National Portrait Gallery.


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The Kalamazoo Civic Theatre's production of "Hairspray" has been extended to May 27, 2016.
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Scotty McCreery performs at Kalamazoo State Theatre on Thursday, Jan. 28, 2016 in Kalamazoo, Mich. (Bryan Bennett / MLive.com)
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Zazios remodeling restaurant and reimagining menu
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2016 Gilmore International Keyboard Festival
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"the Mountaintop" is a production of Face Off Theatre Company.
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Organic Gypsy heads to Las Vegas for national spud contest
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Cottage Inn Pizza opens on Sprinkle Road
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Dig In: The Sugar Bear
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Dig In: The Korea Sy House
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Massie's Michigan Books opens in Allegan
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Dig In: Four Roses in Plainwell has desserts galore.
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Holiday activities about in Kalamazoo on Dec. 5 and 6
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Art Hops beer logo finalists
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Dig In: Rhino's Hometown Pub in Plainwell
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Ballet Arts Ensemble presents "The Nutcracker" on Dec. 5 and 6
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Works from "Colour Correction: British and American Screenprints, 1967-1975," which runs Nov. 27-March 27 at the Kalamazoo Institute of Arts.
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Liberty City Warriors
From Grand Theft Wiki
Revision as of 19:20, 16 June 2013 by Kanzler31 (talk | contribs) (the warriors don't play in SF, Oracle is in Oakland)
The Liberty City Warriors are one of Grand Theft Auto IV Liberty City's two pro Basketball teams. Katt Williams, one of the acts who performs at Split Sides, a bar in Algonquin, said that one player on the team did all the work and the others were just running up and down the court. They're possible rivals with the Liberty City Penetrators, the other pro basketball team in GTA IV Era Liberty City. Nothing much else is known about them.
The team name could be a possible reference or ode to the previous Rockstar Games game The Warriors, based on the 1979 film of the same name.
There's a real life basketball team named the Golden State Warriors, who play in Oakland.


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Everything is connected: people, information, events and places, all the more so with the advent of online social media. A practical way of making sense of the tangle of connections is to analyze them as networks. In this course you will learn about the structure and evolution of networks, drawing on knowledge from disciplines as diverse as sociology, mathematics, computer science, economics, and physics. Online interactive demonstrations and hands-on analysis of real-world data sets will focus on a range of tasks: from identifying important nodes in the network, to detecting communities, to tracing information diffusion and opinion formation.
There are no math or programming prerequisites for the class. There will be a few additional assignments for those with a programming background, which will use the R statistical programming language along with NetLogo.
If you'd like to get a head start, download Gephi and explore some of its tutorials. To explore networks interactively, you can visit the NetLogo demonstrations. If you're itching to read, the Easley and Kleinberg free text on Networks, Crowds and Markets is excellent. The chapters pertinent to this class are 1-5, 13-14,19-21.
The class will consist of lecture videos, which are between 8 and 12 minutes in length. These contain 1-2 integrated quiz questions per video. There will also be standalone homeworks that are not part of video lectures, optional programming assignments, and a (not optional) final exam.
We will be using Gephi for visualization and analysis. The interactive demonstrations will be primarily in NetLogo, which you will be able to access through your web browser. If you would like to complete the programming assignments, which will be done in NetLogo and R, NetLogo is freely available here and R is freely available here.
Yes. Students who successfully complete this class will get a certificate signed by the instructor.


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Timberland PRO Men's Direct Attach 6''' Waterproof 200g Soft Toe Work Boots
$129.99 $139.99*
Save $10.00 (7%)
Product Information:
Stay safe and comfortable on any worksite in the rugged and durable Timberland ® PRO ® Direct Attach 6'' waterproof insulated work boot. The nylon shank gives you the support needed to keep you on your feet all day long while 200 grams of insulation ensures lasting warmth and comfort. The open-cell polyurethane footbed is treated with Agion ® to eliminate odor and enhance comfort.
- Waterproof seam-sealed direct-inject construction provides optimal water protection
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- Lightweight blown-thermal plastic midsole
- Open-cell polyurethane footbed with Agion ® antimicrobial cover
- Classic non-marking rubber lug outsole offers traction and oil resistance
Country of Origin: United StatesWeb ID: 12350434
Customer Reviews:
Rated 4.6 out of 5 by 12 reviewers.
Rated 5 out of 5 by Mother Dicks is the only place I could find wide sizes Dicks is the only place I could find wide sizes! The boot fits my son great!! Thanks for carrying wide sizes,, January 26, 2016
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Rated 4 out of 5 by bonniem Great fit and good durability. I have ordered these before and the fit is good. They wear very well too. April 5, 2015


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Contact Information
1207 21st St Sacramento, CA 95811
1207 21st StreetUSCaliforniaSacramento95811
(916) 444-5631boneheadtattoos.com
Tattoo ShopToday 8AM–8PM
Since 1995, Bonehead Tattoos and Piercings has offered unique art and piercings in a clean, professional environment. Currently, Bonehead offers a friendly staff of male and female artists and piercers available for walk-ins and appointments.
We do everything from Traditional to Tribal. We've got Flash on-hand and like most shops, we have the internet at our disposal. Check out some of the tattoo artist pages on boneheadtattoos.com. When you come in, we'll have tattoo artists on hand that can take your ideas and flesh them out, so to speak.
Our shop minimum is currently $60. Anything else is up to the individual artist.
Google+ URL


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Funding via VisionFund Kenya
His business is situated in a very crowded place with both residential and commercial shops.
With the extra profits, he will open another boutique in the capital city of Nairobi. Daniel believes he is hard-working.
About KADET:
The Kenya Agency for the Development of Enterprise and Technology (KADET) is dedicated to economically empowering its clients by providing financial services to improve living conditions of micro-entrepreneurs and their children across Kenya. KADET is the micro-finance subsidiary of World Vision Kenya. Obtain more information on KADET from the website: www.kadet.co.ke
Success!! The loan was 100% repaid


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The Levon Helm Band
Levon Helm once sang and played drums and mandolin for a certain quintet that was so formidable it was simply dubbed the Band. It created rock for the ages, and lo these many ages later, Helm is still creating improbable, incandescent music, last year winning a Grammy for Dirt Farmer, his first solo album in a quarter-century—improbable because he had seemingly forever lost his voice to throat cancer. His Arkansas yowl miraculously restored, Helm is on a roll, and rolls into town with his superb band just ahead of the release of a new album, Electric Dirt. Like its predecessor, this earthy collection taps country, blues, folk, gospel, and good old rock 'n' roll, mixing originals with apt, critical covers, including the Dead's "Tennessee Jed" (a song Helm was seemingly born to sing), Muddy Waters's "You Can't Lose What You Ain't Never Had," Carter Stanley's "White Dove," and the Staple Singers' "Move Along Train." The horns on two songs were arranged by Allen Toussaint, who also did the horns for the Band's "Life Is a Carnival" and live Rock of Ages album. Helm's current band includes several members of Ollabelle (daughter Amy Helm, bassist Byron Isaacs), plus multi-instrumentalist (and former Bob Dylan associate) Larry Campbell, Brian Mitchell on keyboards, and singer Teresa Williams (Campbell's wife).
Wed., June 10, 7:30 p.m., 2009
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These delicious finger sandwiches are easy to eat between turns and fit in wonderfully with the "Game Night" theme. Themed foods add a festive touch to any gathering ... - read more
Read Throw a Game Night Party - Everything you need for a fun night of eating, drinking, and card- and game-playing, including recipes, cocktails, and planning advice - read more
Please vote if the answer you were given helped you or not, thats the best way to improve our algorithm. You can also submit an answer or search documents about game night foods.


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Material: Solid steel frame, vinyl upholstery
Product Color: Red and Black
Comfort Elements: Padded bench; foam roller pads; comfortable foam grips
Targeted Training: Back and abs
Assembly required
This item is usually shipped via . Estimated time to ship is 1-2 days, please allow 7 to 10 business days for delivery.
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|Property type
|Minimum Stay
|7 nights
These two beautiful villas close to the beach just 10 km from Paphos are situated on one big plot but still secluded from each other. CYP003 is a seafront four bedroom and four bathroom villa with a private pool offering panoramic sea and mountain views from its terraces and balconies. CYP004 is a three bedroom house, also with its own private pool. They are both located in a peaceful area just 50 m from St. George beach and a few minutes drive from the center of Coral Bay Village where restaurants, tavernas, cafés and a supermarket can be found. St. George is a small fishing harbor just beyond Coral Bay. It has a small beach and a few seaside tavernas offering specialties. Do not miss a day trip to the temple of Aphrodite, the temple of the kings, the mosaic of Paphos or Aphrodite's rock said to be her place of birth. Enjoy your coffee or drink at Paphos' harbor with view to the castle which is on the UNESCO list of world heritage sites. In the area you will find a lot of good beaches, such as Ladies Mile Beach, Arnica Beach, Pioneer Beach, Paphos beach Pissouri and last but not least Coral Bay.
*Plus compulsory or optional charges based on actual occupancy or consumption. The payment has to be made in the currency offered by the property manager, before use of conversion tool. Payments in other currencies have to be negotiated beforehand with the property manager. The currency conversion tool is provided for your convenience only and is non-binding.


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Madelinetosh Pashmina Yarn is a similar yarn: merino wool, machine wash, sport (24-26 sts/4 in), 100 gram. You may also like Lorna's Laces Sportmate Yarn, which is another similar yarn: merino wool, machine wash, sport (24-26 sts/4 in), 100 gram, and on size 4 US needles.
What about yarn that have the same look and feel? Find more yarn that is ethically sourced, a smooth / uniform texture, and pills.
You may enjoy taking a look at the Fyberspates Scrumptious 4ply/Sport Challow Pullover , Fyberspates Scrumptious 4ply/Sport Kaelyn Cardigan, Holiday Gift Kit- Fyberspates Scrumptious Luxury Baby Gift Bag, and Fyberspates Scrumptious Sport 4-Ply Bakersville Hoodie kits all using Fyberspates Scrumptious Sport 4-Ply Yarn.
Hopefully our suggested project ideas for Fyberspates Scrumptious Sport 4-Ply Yarn can help you come up with your next exciting new project idea!


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Since their discovery three decades ago, NK cells have been classified as cells of the innate immune system. NK cells were shown to respond rapidly and non-specifically to infection, and were thought to act as a functional "bridge" to sustain the early innate immune response until the later adaptive immune responses could be mounted. In light of new findings showing how NK cells possess nearly all of the features of adaptive immunity including memory, we propose the placement of NK cells as an "evolutionary bridge" between innate and adaptive immunity.
In all of the immunology textbooks, NK cells are presented in sections describing the innate immune system. Ever since Eva Klein coined the phrase "Natural Killer" in 1975 to describe the ability of a subset of lymphocytes able to spontaneously kill tumor cells without pre-conditioning [1, 2], and Klas Karre proposed the "missing self" hypothesis in 1984 to explain the rules by which these lymphocytes function [3, 4], NK cells have been considered characteristically more "innate" than "adaptive". However, the definitions of "innate" and "adaptive" have been blurred by recent findings showing adaptive immune features in NK cells.
According to the strictest definition of the word "adaptive", what does it really mean that an individual cell or organ system can "adapt"? The Merriam-Webster dictionary defines "adaptation" as a "modification of an organism or its parts that makes it more fit for existence under the conditions of its environment". If an immune cell can "adapt" in its behavior in response to encounter with a pathogen and by doing so becomes more "fit" to respond against repeated pathogen exposure, does this not classify it as "adaptive"? Implicit in this argument is the fact that an immune cell must survive after encountering a pathogen in order to adapt. Immunologists have given a name to the persistence and adaptation of immune cells following infection – memory.
Immunological memory has long been a hallmark of adaptive immunity. The ability of previously activated immune cells to persist for months and even years following initial stimulation through their antigen receptors represents a defining trait of immune memory [5–7]. These long-lived cells must then be able to become re-activated and undergo further clonal expansion following subsequent stimulation. In the context of an infection, the secondary or recall response should be more efficacious (i.e. demonstrate more rapid expansion and/or enhanced effector function) and protect the host against a re-encounter with the pathogen. These characteristics have previously only been demonstrated in T and B cells, and there was little evidence that these traits existed in other cell subsets of the immune system.
In a mouse model of contact hypersensitivity, von Andrian and colleagues first provided evidence that NK cells can retain a "memory" of previous exposure to a specific antigen [8]. Contact-hypersensitivity responses, a form of delayed-type sensitivity thought to be mediated by T and B cells containing antigen-specific receptors recognizing haptenated proteins, could be generated in RAG-deficient mice (which lack T and B cells), but not in RAG and IL-2 receptor common-γ chain double-deficient mice (which lack T, B, and NK cells)[8]. This hapten-specific "memory" could be transferred via liver NK cells from a sensitized donor such that a naïve recipient mouse acquired the ability to mediate contact hypersensitivity independent of T and B cells [8]. The ability to mount recall responses were shown to persist for one month and could only be elicited by haptens previously used to sensitize the host, but not by an unrelated hapten, demonstrating specificity [8]. Together, these findings indicate that NK cells have the ability to mount adaptive and antigen-specific secondary responses.
However, the mechanism responsible for NK cell-mediated contact hypersensitivity, as well as the precise NK cell subsets responsible for the hapten-specific "memory", were not defined in this study. Furthermore, these observations left us to ponder: What are the NK cell receptors recognizing haptens on the surface of target cells and what is the nature of the hapten ligand? Why do NK cells from the liver, but not the spleen, contain the ability to mount recall responses? Why would natural selection evolve mechanisms in NK cells to mediate secondary responses against chemical haptens? Wouldn't NK cells more likely have developed ligand specificity and immune memory against pathogens during the course of evolution?
More recently, in a mouse model of CMV infection, we have demonstrated that NK cells possess nearly all of the hallmark features of the adaptive immune system [9]. Using an adoptive transfer system, where antigen-experienced NK cells can be tracked with a congenic marker, we have observed that Ly49H-bearing NK cells can undergo robust expansion leading to long-lived memory cells persisting in the host for at least months after infection [9]. Furthermore, memory NK cells have the capacity to become re-activated, and produce more IFN-γ and degranulate more robustly than resting NK cells from naive mice [9]. Upon re-encounter with murine CMV (MCMV), memory NK cells can undergo vigorous secondary expansion with comparable kinetics to naive NK cells, but are more protective than resting NK cells following virus challenge [9]. Analogous to previously measured endogenous or TCR-transgenic T-cell responses, NK cells possess the feature of "memory' found in CD8+ and CD4+ T cells that defines them as being adaptive immune cells. Based on transcriptional microarray analyses, T cells have been shown to change their molecular profile as they become activated, undergo expansion and contraction, and become memory cells [10]. Similarly, future studies characterizing the gene transcript expression in resting, activated, and memory NK cells will give us clues into how NK cells become long-lived and persist for many months following virus infection. Together with the von Andrian study [8], these observations prompted us to re-examine, in this mini-review, our current criteria for partitioning the immune system.
Cells of the innate immune system generally respond rapidly and "non-specifically" to "stress" or to conserved structures shared by microbial organisms (PAMP) usually manifested by inflammation following tissue damage and pathogen invasion. Many of these cells (mainly of the myeloid lineage, but including NK cells) are present at the site of injury or are immediately recruited, quickly mediate their effector functions, and are thought to disappear after a few hours or days (Fig. 1).
Meanwhile, cells of the adaptive immune system (from the lymphoid lineage), which have never previously encountered the antigen or pathogen, typically mount a response much later, after the antigen has been delivered by antigen-presenting cells to the draining lymph nodes or spleen where antigens (either whole or processed) are presented to B and T cells (Fig. 1). These cells (possessing somatically rearranged receptors) become activated, proliferate to increase the number of effectors, and traffic to sites of infection, mediating highly specific anti-pathogen responses. Following pathogen clearance, cells of the adaptive immune system reside in lymphoid and non-lymphoid tissues for months and years, ready to quickly respond when the pathogen is re-encountered (Fig. 1). NK cells, previously thought to respond and then disappear after one or two weeks, have now been demonstrated to reside in multiple organs as long-lived memory cells [9], ready to mount robust secondary responses against pathogen invasion (Fig. 1).
What are the attributes that immunologists have formulated to distinguish innate from adaptive immunity (Table 1)? Does the rate of the responding cell dictate whether that particular cell type is considered "innate" or "adaptive"? Or does the specificity with which the cell recognizes pathogens and the location at which these cells are primed determine the nomenclature and categorization? Does the longevity of the cell once it becomes activated as a result of infection or immunization and the ability to become re-activated following subsequent infection define it as a cell of adaptive immunity? Or must a cell contain genetically rearranged receptors for it to be categorized as a part of the adaptive immune system? In the end, the question really becomes how stringent our parameters are by which we define cells of the immune system (Table 1).
NK cells are known to respond rapidly against tumor cells and provide a front-line defense against pathogens. However, the speed at which NK cells respond to infection should not dictate that they are cells of innate immunity. True, innate immune cells do generally respond quickly against pathogen encounter; however, the definition of innate immunity should not be confined to this characteristic alone. Indeed, while NK cells can rapidly secrete effector cytokines such as IFN-γ during inflammation due to high levels of type I-IFN or IL-12 and IL-18 in the environment [11, 12], memory CD8+ T cells possess the same ability to secrete cytokines in the absence of cognate antigen [13–15], and no one would argue that this latter cell type should be classified as "innate". Furthermore, functional parallels exist between NK cells and CD8+ T cells. When an NK cell encounters its cognate ligand on a target cell, it mediates cytotoxicity (typically by directional release of perforin and granzyme) and secretes effector cytokines (such as IFN-γ) in a manner nearly identical to that of effector and memory CD8+ T cells [16–18].
What about "specificity" (or lack there of) as a definition of adaptive versus innate immunity? If the cells of adaptive immunity are strictly identified as those containing antigen-specific receptors that have productively rearranged their genes during development or are able to undergo somatic hypermutation, then our definition is clear and simple. T and B cells contain such receptors – every other cell in the immune system does not. By this definition, T and B cells are the only cells that are highly specialized and allow the host to be completely adaptable in its response to potentially every possible infection and antigen, and thus are unambiguously the only cells belonging to the adaptive immune system. However, if "specificity" is defined by the cognate recognition of an immune receptor for a unique ligand encoded by a specific pathogen, which is not shared by other pathogens, then NK cells demonstrate immune specificity as well. The Ly49H receptor expressed on a subset of NK cells appears to be exquisitely specific for the MCMV-encoded m157 glycoprotein [19, 20]. Ly49H has not been found to recognize viral ligands encoded by any virus other than MCMV, and an m157-related protein has not been identified in any other virus, although it is impossible to completely exclude that Ly49H will be found to recognize ligands encoded by pathogens other than MCMV. Crystal structures of the m157 glycoprotein have revealed that it bears many striking similarities to MHC class I proteins, although it does not bind peptides or associate with β-2-microglobulin [21]. The specificity of the Ly49H receptor for m157 has been demonstrated using a mutant strain of MCMV lacking the m157 gene; Ly49H+ NK-cell responses were abrogated in mice infected with an m157-deleted virus [9, 22]. Recently, another activating receptor on mouse NK cells, Ly49P, has been demonstrated to recognize MCMV-infected cells, and this specific interaction is dependent on the viral component m04 [23]. In humans, specific NK cell subsets that preferentially expand during CMV infection have been documented as well [24–27]. Furthermore, analogous to the TCR, which requires ITAM-bearing CD3 subunits to transmit a complete signal in T cells following TCR ligation of peptide-MHC, activating Ly49 receptors require the ITAM-bearing signaling molecule DAP12 to initiate a full activation signal in NK cells [28]. Thus, NK cells, at least with respect to Ly49H+ NK cells, share the adaptive immune criteria of "specificity" with B and T cells (Table 1).
In addition to specificity and immune memory, NK cells undergo developmental and peripheral tolerance mechanisms similar to B and T cells to safeguard against autoimmunity. During development, adaptive immunity relies on the "selection" of immune cells that can distinguish between the host's own cells and unwanted invaders. Whereas T cells undergo selective pressures during development in the thymus (where checkpoints ensure self-tolerance and prevent autoimmunity) [29], NK cells have also been shown to undergo similar "selection" processes during their development. As with T cells, education of NK cells in the bone marrow also ensures that these cells will be tolerant of "self" in the periphery [30, 31]. Immature NK cells have been shown to require interactions between their inhibitory receptors with MHC class I molecules to become fully functional in the periphery; without these interactions, NK cells are rendered hypo-responsive [30, 31]. Furthermore, akin to negative selection of thymocytes and peripheral T-cell anergy, when in experimental models in which developing Ly49H+ NK cells encountered their cognate viral ligand m157 in the bone marrow, tolerance mechanisms were put in place to delete these immature cells or keep them unresponsive in the periphery [32, 33]. Further regulatory mechanisms of self-tolerance controlling peripheral NK cells (as has been demonstrated in regulatory T cells) remain to be defined. Additionally, studies examining the environmental cues for NK-cell activation, proliferation, and homeostasis will give much insight into how these cells are triggered and subsequently regulated as they differentiate into effector and memory cells. Understanding the molecular mechanisms governing the survival and function of NK cells will allow us to harness the protective capacity of this cell subset in vaccination against infectious pathogens. Together, the many developmental, phenotypic, and functional similarities that exist between NK cells and T cells suggest that NK cells are a good candidate to occupy the missing evolutionary link between innate and adaptive immunity.
The innate immune system is widely believed to be evolutionarily more ancient than the adaptive immune system. Whereas innate immunity is found in nearly all organisms (including jawless fish, worms, insects, and even starfish), adaptive immunity is thought to have first arisen in the jawed vertebrates [34–37]. Because reproduction is required for the perpetuation of a complex species and more time is required for vertebrates to reproduce (compared with less complex creatures), the primitive immune system might have evolved the ability to recognize and "remember" specific pathogens in order to mount stronger attacks each time a pathogen is encountered. The ability of adaptive immunity to adapt its defenses against future viral, parasitic, or bacterial challenges ensures that the higher organism will survive long enough to allow for the propagation of its progeny.
Although we may never fully understand how the cells of adaptive immunity evolved from their predecessors, there is evidence of these mechanisms when comparing higher animals to lower organisms – at some point during the evolution of species, T and B cells appeared, having acquired recombinase proteins necessary to rearrange V(D)J genetic elements and diversify antigen-sensing receptors [34, 36, 38, 39]. Even within the study of our own immune system, we can find clues in potential "predecessor cells" such as NK cells, which possess traits of both innate and adaptive immunity. If there is a subset of cells that constitutes an evolutionary "bridge" between innate and adaptive immune cells, this population would presumably contain characteristics of both systems. Indeed, NK cells can mediate both "specific" adaptive-like responses, as well as "non-specific" innate-like responses. In addition to the cognate recognition of m157 and subsequent adaptive immune responses mounted by Ly49H+ NK cells, Ly49H− NK cells that do not encounter cognate antigen can still participate as "bystanders" [40, 41], producing IFN-γ in response to inflammatory cytokines such as IL-12 and IL-18 secreted by activated myeloid cells [11, 12, 42], but not clonally expanding. A recent study suggests that such "bystander" activation of NK cells can result in "memory-like" properties [42]; however, how these in vitro cytokine-stimulated NK cells compare with NK cells following viral infection in vivo needs to be further evaluated. Even macrophages have recently been proposed to possess "adaptive" features in their ability to regulate inflammation [43]. Reciprocally, unique T and B cell subsets (γδ, CD8αα, and NKT cells; and B1 and marginal zone B cells) have been discovered that are limited in their antigen-specific receptor repertoire, function early in the immune response, and thus could be considered "innate"-like [44, 45]. Altogether, these cells form both an evolutionary as well as a functional "bridge" between innate and adaptive immunity.
A fundamental distinction between NK cells versus B cells and T cells is the ability of B cells and T cells to generate an almost infinite repertoire of antigen-specific receptors as a consequence of somatic gene rearrangement. In contrast, NK cells are limited to the receptors that are encoded by genes pre-existing in the genome. Therefore, the receptors expressed by NK cells must be selected for at a population level, rather than the individual level. However, the murine Ly49 genes and the primate KIR genes are polygenic and exhibit extensive allelic polymorphism, thereby providing for considerable diversity within the species. Of note, the activating receptors within the Ly49 and KIR gene families are evolving more rapidly than the inhibitory receptors from which they arose, likely due to selective pressure exerted by pathogens [46]. If NK cells are restricted to receptors encoded by germline genes, this obviously limits their total repertoire potential, and implies that selection of these genes will be driven at the population level. This selective pressure might have resulted in the recognition of host-encoded rather than pathogen-encoded ligands, for example the recognition of the host's stress-induced ligands of NKG2D. The evolution of NK receptors for pathogen-encoded ligands could be either for broadly cross-reactive molecules, such as PAMP (which has not yet been documented for NK-cell receptors), or possibly for selected pathogens that persist in the host and must be controlled throughout the lifetime of the host, such as herpesviruses.
As immunologists, we sometimes too strictly partition cells and cell subsets, often in a binary fashion (e.g. Th1 versus Th2; B1 versus B2, etc.), pigeon-holing or artificially imposing forced-categorization that oversimplify the intricacies of the immune system, and thus hazard overlooking new biological concepts. When placing stringent boundaries on how specific cell subsets can be categorized and named, we become susceptible to continuously arguing semantics. Rather than fretting over how to classify, we should instead celebrate the unexpected observation that furthers our understanding of the natural world, and discover how these new concepts in biology can be translated towards advancing human health and fighting infectious disease.
L.L.L is an American Cancer Society Research Professor and the Irvington Institute Fellowship Program of the Cancer Research Institute supports J.C.S. Supported by NIH grants AI066897, AI068129, CA095137, and AI64520.
Conflict of interest: The authors declare no financial or commercial conflict of interest.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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A:Obama also raised it this year. Lowering the FICA tax meant that people will have a lower income when they eventually collect SS in the future.
A:Thank you Radical Democratic Party for the reversal code --down is up and up is down!
A:The FICA tax just went up under Obama.
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text:
George William Hunter
Position: B
Height: 6-1 Weight: 185 lbs.
Born: November 5, 1942 in Camden, NJ
High School: Delaware Twp.
College: Syracuse (school history) (Hunter college stats)
Weighted Career AV (100-95-...): 0 (15060th overall since 1950)
Other SR Links: College Football at Sports-Reference.com
Output includes all passing, rushing, and receiving plays.See all Billy Hunter Super Bowl plays using the Super Bowl Play Finder


text:
THE HELLENIC PERIOD (from 650 to 300 B.C.)
THE beginnings of this period are marked by an intimate mingling of scientific, cosmogonical and philosophical considerations. If Hegel is to be believed, these considerations would have manifested themselves in the form of a thesis, anti- thesis and synthesis on the problem of existence. But the historic reality does not correspond to this brilliant conception. In fact, from its first appearance, Greek philosophical thought betrayed diverse tendencies more or less opposed, which often ignored one another. It was not with one single problem that it was occupied, but rather with a number of questions more or less disconnected, concerning the origin and the purpose of the Universe. From the first there can be clearly perceived three tendencies, which persisted through the centuries unto our own times. The school called Ionian applied itself to external phenomena, and endeavoured to find in them the final explanation of reality. At almost the same period, the Pythagorean school, in the south of Italy, sought, on the contrary, this explanation in number, an abstract principle which is not directly provided by the senses. Heraclitus, indeed, considered that the unstable "becoming" was the very substance of reality, and that, in order to know it, recourse must be had, not to intelligence, but to intuition.
In spite of these divergences, there is, however,


text:
Stay Close to Me (GN)
Title: Stay Close to Me
Volume: GN
Pages: 200
Distributor: Digital Manga Publishing
Release date: 2010-10-06
Suggested retail price: $12.95
Age rating: 18+
Yuzu and Icchan are childhood friends, and as long as Yuzu can remember, handsome Icchan has always there for him and would come and rescue him like a prince in a shiny armor. But time has changed both of them; now Yuzu has grown taller than Icchan, and together, they look like a huge princess and an ultra-popular, handsome Prince. They aren't asking for trouble, but they always seem to get themselves into it anyway! A guy from the Karate club tries to start a fight... A beautiful girl tries to hit on Yuzu... Don't they know Yuzu and Icchan just want to be left alone?!
Story and art by Yaya Sakuragi.
(added on 2010-06-18, modified on 2011-10-08)
- Encyclopedia information about Stay Close to Me (manga)


text:
tellverbuk /tel/ us /tel/ told, told
tell verb (SPEAK)
tell verb (KNOW)
More examples
- I could tell from her expression that something serious had happened.
- You can tell it's autumn because the leaves have started to fall.
- Who can tell what the future holds?
- Can you tell the the difference between poisonous mushrooms and edible varieties?
- I could tell he was really upset, though he tried not to show it.
You can also find related words, phrases, and synonyms in the topics:
tell verb (HAVE AN EFFECT)


text:
Obama picks fight with "extreme" Tea Party
Paul Bedard:
The Tea Party's been out of the news for months, but President Obama's reelection team must sense that they're up to something because in promoting his small dinner with low-dollar donors the campaign is highlighting a former Republican scared off by the Tea Party.
In a new fundraising letter, Julianna Smoot, deputy campaign manager, said one of the winners in the dinner raffle who will be sitting next to President Obama is from Ohio, "one of all too many states where Tea Party extremism has completely seized the Republican Party."
It gets worse for the poor Ohioan identified simply as Jim: "When the Tea Party agenda — the same one that Mitt Romney and Rick Santorum have been fighting to take to the White House — personally affected Jim, it shook him into action."
Now he's a Democrat organizing for Obama. Read the letter below:
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Cross clobbers St. John's 52-16
The Stags came up short against Hanahan on Friday, falling 35-18.
Berkeley homecoming photo gallery
The Kennedy Center Located in Moncks Corner and Goose Creek had their 25th annual Red Ribbon Picnic in the Park Family Fest on Oct. 18, 2015. It is …
The Town of Bonneau enjoyed their annual Peanut Festival October 16 and 17. (Photos by Ann Mack)
(Photos by Ann Mack) Taylor's on Main is a new business in town catering to Ladies and Children's Fashions. They are located in the old River's …
Berkeley defeated Timberland on Friday. (Photos by Debbie Merlo)
Photos by Ann Mack
Pictures from Summerville's win over Berkeley Sept. 4. Joe Call notched his first victory as the interim coach for the Green Wave.
Timberland defeated Cross 37-0 on Friday at THS. (Photos by Rob Gantt)
The August Berkeley County Business Mixer was hosted by Pruitt Health located in Moncks Corner. (Photos by Ann Mack)
The Joshua Milligan Police Summer Camp was held in St. Stephen. (Photos by Ann Mack)
Photos of Berkeley, Stratford, Goose Creek and Hanahan from the Stratford 7 on 7 passing tournament on Wednesday. (Photos by Rob Gantt)
Moncks Carolina defeated Carolina on Thursday in the Dixie Youth Majors tournament in Moncks Corner. (Photos by Dan Brown)
The Moncks Corner all-stars defeated Hanahan 13-3 during the Dixie Youth 9-10 tournament at Wescott Park on Thursday. (Photos by Rob Gantt)
Photos by Dan Brown
Pictures from opening day of the South Carolina Dixie Youth Baseball AAA District 7 All-star Tournament being held this week at Wescott Park. Teams …
Moncks Corner defeated Pepper Hill National on Tuesday to stay alive in the Dixie Youth Machine Pitch all-stars tournament in Hanahan. (Photos by Rob …
Photos by Ann Mack
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Oh thank goodness. After 77,000 backers, $4 million raised and nearly three years in development, Obsidian's Pillars Of Eternity [official site] is here, and it's just stunning.
This is the RPG I've been craving since Planescape: Torment, the first to win my absolute love since Dragon Age: Origin. It's a vast, deep and wonderfully written game, malleable to how you want to approach the genre, replete with companions, side-quests, an enormously involved combat system, and lasts a solid 60 hours. Here's wot I think:


text: I do not know whether it is a problem or not but when I boot on the login screen I cannot see the cursor for typing. I am using tab to enter the log screen and able to type password. But the mouse is simply not visible. I changed the mouse port also. But still the problem remain intact. I am not able to understand what issue lies here. The mouse works well on the desktop once logged in.


text:
Commotion in the Ocean
Giles Andreae
Illustrated by David Wojtowycz
- Fun collection of poems that are great to read aloud and share with preschoolers
- Bright bold illustrations of fish and life under the sea
- Children will enjoy repeating the rhymes
Publisher: Orchard
'My son likes to hear me read the poems...'
I loved this book! My son is a little young for it at the moment but he likes to hear me read out the poems. A good one to take to the beach in summer!
About the author
What families say
it was fun
It is fun reading this book
Great colourful pictures nice rhyming story too.
This was one of the first books we read with my daughter, we love the rhymes and it got us hooked on Giles Andreae as an author with our favourite being Giraffes can't dance.
My daughter and I love this book. I love the rhyme that runs through the book, very enjoyable to read as a parent and my daughter especially likes looking for the starfish on each page as well as learning about all the different animals. Educational and fun at the same time.


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Artist: The Isaacs
Album: Miscellaneous
Genre: Country
I heard about these kids walkin' on a train track
Forty tons of steel bearin' down on them
And they just turned their backs
Channel 5 asked the one who survived
"Son, why'd you do such a thing?"
No reply but his eyes cried
Peace, I just need some peace
If I have to, I'll do anything
Don't need your love or your sympathy
But I cannot go on living without peace
I know a man who sits and stares at kitchen cabinet door
He hides a whiskey bottle he hasn't touched since
Well, this is day four
He told his wife, this time he would try
She was just about to leave
No reply but her eyes cried
Peace, I just need some peace
If I have to, I'll do anything
Don't need your love or your sympathy
But I cannot go on living without peace
I have a friend who's looking for God
A few good self-help books is as far as she's gotten
Say a prayer tonight for that desperate child
Say a prayer tonight for that man and his wife
Say a prayer for the hurtin' searchin' for the one thing we all need
If you don't know what to say
Look up to Heaven's face
And pray peace
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text:
Last Friday evening I was transprted 70 miles south of my home to a hosipital because my membranes had ruptured!! Rewind three weeks and I had my first gush of fluid. I would have sworn my water had broken then. I went to the birthing center and it tested negative but I was contracting. They did a fetal fibronectin test and it came out positve!! So, everyother day I was in the hospital due to leaking of fluids. Negavive everytime and I felt like I was going crazy cause I knew someting wasn't right. Finally last Friday the 3rd it came back positive for amniotic fluid. So, in a nutshell I was leaking for two weeks before it actually tested positive. I am lucky I didn't develop an infection. I am stable and haven't developed an infection yet and baby is looking great...measuring 4lbs 12 oz, which I am told is a good size. I have been given steroids but now we just wait till I either go into labor on my own or we decide if we want to be induced at 34 or 35 weeks. I am 33 weeks as of yesterday. The waiting is the hardest part and I am so far from home.
day 7 of bedrest in the hospital
Comments (4)
The good news is you've made it very far, and your baby is a great size. I know it's hard to be away from home, but I wish you the best of luck!
Survived 9 weeks of bedrest
Zachary Thomas born 3/30/09 at 31 weeks 6 days
Hang in there. God so glad you don't have an infection. I'm also away from my home in the hospital (6hours). I't a long commute for my DH. The infection thing is very scarey . Yesterday I was stressed out when they had to do a amnio to rule out infection. No infection, thank god. 33 weeks and 4lbs 12 oz is great, in my opinion so are the steroids at this point.
I can really relate to being away fro home, but you are almost there. I was commenting on the FFN test, look at my thread. Not that I'm some expert. But curious about the use of it.
Hang tight , wishing you the best
45 days in hospital 31 weeks on MOnday!!!
Hang in there...my first baby was a preemie at 30 wks 6 days because of premature rupture of the membranes. With him, it was a huge gush of fluids and there was no way of stopping labor later. He was born 19 hours after they gave me the steroid shot, was 4 lbs 3 oz and stayed 5 weeks and a half in NICU. He is now 3 yo and doing great:)..you are in a better shape because 33 weeks is huge and 4 lbs 12 oz is a very good size. You are in good hands in the hospital, but it is hard being away from home...I remember counting the hours with my first son and regretting every drop of fluid leaking with every contraction, but things turned out fine at the end...so be patient, good luck:)
Mom to 3 yo Gabriel born at 30wks 6days, now expecting Michael due 05/14/09. bedrest for short cervix.
wow, i'm impressed how you knew. funny how that sometimes works. i'm at same 33 weeks and in hosp on bed rest. have been here for 9 weeks and around 32 weeks the drs finally all sighed with relief knowing if the lil guy decides to come out now he'll likely be ok. its good for you to be at the hosp with the nicu tho, even being so far from home. its hard i know. surround yourself in the knowledge of all who love and care for you and it won't be as hard all the time. take care and good luck!


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David Navara
nejlepší český šachista
Robert Cvek
šachový velmistr
Mistrovství České republiky z pohledu trenéra
Vlastimil Chládek
ředitel Dopravních staveb Brno
Vlastík je zpátky
Vlado Hrtko
Manažer se smyslem pro černý humor
Matrix alebo božie mlyny?
Pavel Matocha
předseda Pražské šachové společnosti
Simultánky s Garrim
Michal Špaček
Amatérský šachista, profesionální ekonom
A znovu ve vlaku - z Vídně do Prahy
Otakar Válek
ředitel strojírenské firmy
Slavík, Jolanta a Kalousek
Štěpán Žilka
šachový mezinárodní mistr
Nabízím remis
Luděk Sedlák
skladatel studií a vydavatel Šemíka
Kouzelná úloha mistra Josefa Maršálka
Ján Markoš
nejlepší slovenský šachista a teolog
Šedá zóna
David Kaňovský
šachový mezinárodní mistr
Mistrovství světa v Agricole aneb od šachovnice k ovečk...
Martin Habina
Igor Němec
předseda Úřadu na ochranu osobních údajů
Šachy s prezidentským kandidátem
Václav Klaus
Ředitel gymnázia
Nejhorší na světě je prohrát šachovou partii
Jan Hofírek
otec a trenér
Napoleon Bonaparte a šachy...
Vítězslav Houška
spisovatel a publicista
Slet šachových celebrit na Kampě
Soňa Pertlová
šachová mezinárodní mistryně
The most beautiful studies and problems of Mario Matouš, the best Czech chess composer of the 20th century, and bizarre chess stories of Pavel Houser connected by illustrations of Kristina Peřichová into one splendid book.
The book was published also in limited numbered edition (100 copies), bound in imitation leather with an embossed diagram, paper cover and sewn ribbon bookmark.
On 240 pages you will found 45 studies and problems, 22 stories and 36 illustrations. The book is supplemented by biographies of both of the authors and several yet non-published photos. The book was published by Prague chess society in 2014.
(limited edition in imitation leather - 999 CZK + postage)
333,- Kč (+ postage)
The book can be ordered at an e-mail address email@example.com. Please give your full name, address and phone number.
[25.04.2016] - The chess match between the World Junior Champion Richard Rapport and the best Czech chess player David Navara will be the main event of this year's CEZ CHESS TROPHY 2016, which will be held in Prague from the 3rd until the 8th of June in the usual premises: the Michna Palace on the Kampa Island.
The grandmasters will be competing in a match of 4 standard games in the classic tempo (counted to ELO) and the match will be commentated on by an experienced GM Robert Cvek in the commentator hall. The duel will be accompanied by a rich chess programme, as it's customary during CEZ CHESS TRO... [all]
[22.04.2016] - Chess is not just a sport, but also art and a social event. The Chess Train emphasises this cultural side by choosing the authors of its posters from the ranks of famous Czech artists.
The painting for the Chess Train 2016 poster was created by the painter Martin Velíšek and you can take a look at all three of his paintings with the motif of chess and trains here. Velíšek's playful, cheerful, maybe even punk style goes hand in hand with the view of the Prague Chess Society that chess should not be taken too seriously. That despite the seriousness and difficulty of this game, it should... [all]
[04.03.2016] - This year's Chess Train is ready and if you would like to be on board, you can register now. From Friday 7 October until Tuesday 11 October you can visit the beautiful cities of Regensburg, Innsbruck, Salzburg, and Cesky Krumlov and play in a chess tournament during the train ride.
The railway cars are converted into tournament halls which will seat 120 chess players from all over the world. Last year, the tournament saw players from 19 countries, from beginners through experienced club players to international grandmasters. The winner of the Chess Train 2015 was the Swedish GM Lars K... [all]
[12.11.2015] - Chess players love post mortem analyses in which they try to convince their opponent they were actually winning all the time; if only they had found the final winning move. Because there were a couple of prizes left in the Chess Train 2015 prize fund, we announced a post mortem competition for the best photo from the Chess Train.
To this day, we have received 41 photos and the two judges Pavel and Anička have chosen 7 winning ones. Although we agreed immediately on the absolute winner – Luboš Kejzlar and his photo Farewell – we debated long and hard about the other ones, consulted wit... [all]
[15.10.2015] - A group of Swedish chess players dominated the Chess Train 2015. The cold weather that accompanied this year's chess playing on the railways of Central Europe apparently suited the Scandinavians more than other participants. The winner of the tournament was the Swedish GM Lars Karlsson, the Swedish chess player Kare Gillstring achieved the best performance over his rating, and the Swedish team along with one American also won the team competition. The Philippine GM Julio Sadorra came second in the individual competition; the German GM Raj Tischbierek came third. The best Czech chess player w... [all]
[12.10.2015] - Experienced Swedish grandmaster Lars Karlsson is on the 1st place with 7,5 points out of the 8 games. After 4 days he has the margin of the full point out of the next two players - GM Julio Sadorra and GM Raj Tischbierek.
The best from the Czech chess players is Jaroslav Satranský (6 points), who in the 8th round defeated Jan Klaus (5 points). The 1st among the women is WIM Martina Kořenová (5 points).
In the team competition the Sweden@USA is leading. One point behind is the Team 50 Moves (the winner of the last year) and on the 3rd place is the Club GROP.
The Chess Train ... [all]
[11.10.2015] - Chairman of the board of Czech Railways Pavel Krtek played one chess game in the lounge car of the Chess Train 2015, wished good luck to all the participants and announced, that chess will be part of the on-board games portal on Pendolino and Railjet trains.
The Chess Train 2015 started on Friday October 9th. The 1st part of its ride went to Dresden, the 2nd to Wroclav next day. Grandmasters Julio Sadorra (Philippines), Lars Karlsson (Sweden) and Raj Tischbierek (Germany) won their games in the first 4 rounds.
The festive opening of the Chess Train 2015. From the left: ch... [all]


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text: I have had the iPhone 4 and before that I have used the iPhone 3G for over a year. Now the N8 seems to be an excellent phone. When it was first released the price was very high. Now it is very descent. The camera and look is the best thing I have seen in this. But still there are some major things annoying with N8 like battery life, Flash, Widgets and application universal support. Other than this everything seems to me fine. Still overall I am slight worried. I dont know whether it is a better option for me to switching from iphone to N8. What do you say?


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Top 10 Most Downloaded Softwares for Free Download of this month 2013
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Joe Raedle/Getty ImagesThe accounting of the financial cost of the nearly decade-long Iraq War will go on for years, but a recent analysis has shed light on the companies that made money off the war by providing support services as the privatization of what were former U.S. military operations rose to unprecedented levels.
Read the original article on International Business Times. Copyright 2013. Follow International Business Times on Twitter.


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Why Does the Stock Market Drop When the Fed Raises Rates?
When it costs more for businesses to expand, these businesses likely become less valuable to investors. What should you do when the stock market drops?
When it costs more for businesses to expand, these businesses likely become less valuable to investors. What should you do when the stock market drops?
Your bank account may not reflect it, but the total net worth of American households reached a new high in the second quarter of 2015.
The S&P 500 index showed nine new 52-week highs and eight new lows, while the Nasdaq recorded 31 new highs and 75 new lows.
This week's back-to-back equities sell-off might have been a chance to ride a U.S. stocks rally towards the end of the year.
When searching for solid dividend stocks, look for ones that are growing income because it's likely they'll use those increased earnings to boost dividends.
Job growth increased solidly in November in a show of the economy's resilience, most likely paving the way for the Fed to raise interest rates this month.
Private companies added jobs at a solid pace in November, providing a positive sign for the Federal Reserve as it prepares to raise interest rates.
The economy grew at a healthy clip in the third quarter, which could help give the Federal Reserve confidence to raise interest rates next month.
U.S. stock indexes closed slightly lower in quiet trading Monday after a week of strong gains, while a big health care deal failed to impress investors.
Consumer prices rose in October after two straight months of drops as the cost of gasoline and a range of other goods rose.
The S&P 500 index ended little changed Friday, as Wall Street took a strong U.S. jobs report as a sign the Federal Reserve will soon raise interest rates.
Job growth surged in October after two straight months of tepid gains, with the unemployment rate hitting a near 8-year low in a show of domestic strength.
U.S. productivity slowed in the summer, while labor costs rebounded yet stayed at a level suggesting only modest inflation pressures.
Stocks registered their strongest monthly performance in four years Friday, even as they finished lower on the day amid a mixed bag of earnings reports.
Stocks slipped Thursday as the market weighed a possible interest rate hike, disappointing tech earnings and a possible massive pharmaceutical merger.
Economic growth braked sharply in the third quarter, but solid domestic demand could encourage the Federal Reserve to raise interest rates in December.
Stocks on Wall Street slipped Tuesday on uncertainty over the U.S. rate outlook and disappointing results from Ford and other companies.
U.S. stocks jumped Thursday with the S&P 500 index hitting a two-month high on stronger-than-expected corporate results from companies including McDonald's.
Consumer prices recorded their biggest drop in eight months in September as the cost of gasoline fell.
Stock investors don't necessarily need to fear rising interest rates, but they should keep in mind that some sectors could fare better than others.
U.S. import prices barely declined in September, with oil prices rebounding and the drag on prices from a weak global economy appearing to moderate.
Stocks rose in a volatile session Wednesday, led by a rebound in biotechnology companies that pushed the S&P 500 to its highest level in three weeks.
Profits have soared since the global financial crisis at the five biggest U.S. banks with market-making dealing operations, a report finds.
Exports took a hit from an ailing global economy in August and imports from China surged, fueling the largest expansion of the trade deficit in five months.
The stock market is a leading indicator for the economy. So given recent volatility, should investors be worried about the economy slipping into recession?
Stock indexes jumped more than 1 percent Friday after worries about the economy gave way to a robust rally in beaten-down energy and materials stocks.
U.S. employers slammed the brakes on hiring over the last two months and wages fell in September, raising new doubts about the strength of the economy.
The pace of factory growth slowed in September while new jobless claims pointed to a tightening labor market, giving mixed messages on the economy's health.
U.S. stocks closed sharply higher Wednesday as investors looked for bargains among beaten-down shares and the biotechnology index bounced back.
The Dow and S&P 500 rose Tuesday after a volatile session, though concerns about the health of the global economy kept investors enthusiasm in check.


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Hey all, I'm looking for recommendations for a good outdoors shop in Seattle, specifically near Seattle University.
My sister lives there, and I'm looking at getting her a gift certificate to a good local shop. She's into hiking, backpacking, and ultimate frisbee. She has a bike, but I'm pretty sure it's mostly for transportation, so a bike-specific shop may not be the best option. Sorry!
I'd like to avoid the yuppie shops who sell %95 outdoor fashion (ie: NorthFace), but instead find a shop that sells useful outdoor gear, at somewhat reasonable prices. Also, I definitely want to go local, so no Dicks, MC, REI or EMS.
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Denigrating the Status of the Holy Prophet
Blessed and purified will the Prophet remain from the slanders inflicted upon him by so-called Muslims. Despite attempts from several interests to take away from the character of the champion of humanity, he remains the Seal of Messengers and the revolutionary figure that set mankind free with the message he brought. It is unfortunate that today there are those in the Muslim world who claim celebrating his birthday is an innovation and must be prohibited. Their actual purpose is to prevent us from believing there is reason to celebrate the Prophet's life, yet if there is ever a personality in all of history to celebrate and revere, it is none other than Prophet Muhammad.
From the cradle of time to its end, the Earth will never be graced with another man whose merits include being a social reformer, humanitarian, teacher, religious guide, diplomat, philanthropist, the last messenger and the savior of humanity, amongst a list that will forever remain limitless when attempting to define the Prophet Muhammad (peace be upon him and his progeny). In The 100: A Ranking of the Most Influential Persons in History, Prophet Muhammad is named the most influential figure in history, and rightfully so. From historians to poets, the personality of God's last messenger has captured the world. In a prose by Rumi, he illustrates the magnanimity of the Prophet's legacy: "The infant Muhammad became lost and his nurse Halima, dissolved in tears, was consoled with the words: 'Do not grieve, he will not become lost to thee; nay but the whole world will become lost in him!'"
"And thou (standest) on an exalted standard of character." (68:4)
From the first prophet, Prophet Adam (peace be upon him) to the Seal of Prophets and Messengers, the goal has been universal and one: invite mankind towards the One Creator. Muslims accept the scripture of the Holy Qur'an as pure truth and it is evident by the divine sentences found within that none other than Prophet Muhammad has destroyed the idols and liberated mankind from submission to man-made fallacies of religion, leading us towards the greatest freedom – worshiping God, the Most High. Indeed, the Holy Qur'an states regarding the seal of Prophethood: "We have not sent you except as a mercy to mankind." (21:107)
It is not only us laymen who praise Prophet Muhammad; the Lord of the Universe says in the Qur'an: "Verily Allah sends blessings upon the Prophet, and his angels ask Allah to bless him. O you who believe, ask Allah to send blessings upon him and greet him with peace." (33:56)
The Troubling Denigration of his Status
While differences remain embedded among Muslims, we take great offense at comments made in publications disparaging the impeccable perfection that is the Prophet's character. We have threatened to boycott complete nations over cartoon drawings and rioted over films and books that have portrayed the best of mankind in a negative light. However, this movement, which seeks to deliberately – and on occasion, covertly – insult and reduce the character of Prophet Muhammad is not an invention made by the "enemies of Islam".
In fact, even in Salman Rushdie's infamous Satantic Verses, many of the narrations and stories are not figments of his imagination but rather can be found in the so-called "authentic" books of Hadith. While there was a rush to condemn the blatant falsehood and slander of the Holy Prophet in the book, few Muslims have considered what fueled the fire. Satantic Verses was substantiated in the eyes of its supporters because despite being erroneous and self-contradictory, it was backed up with fabricated events and narrations reported by a number of questionable characters whom the overwhelming majority of the Muslim world accepts as respectable "companions". Although the accusations made by Rushdie in his book are incorrect, many others have taken the initiative and continued to use inconsistent Hadiths and traditions to paint an increasingly negative and false portrait of our Prophet. This is due in large part to the Muslim world's failure in distancing itself and condemning the many Hadiths found in these books that question or even contradict the high status of Prophet Muhammad, which is clearly proven in the Holy Qur'an itself. It is indeed unfortunate that the Muslim world gives infallible status to certain collections of Hadith which actually contain several extremely ridiculous and obviously false narrations about the Prophet.
From Messenger to Mailman
Prophet Muhammad's esteemed personality had ushered in an era of perfection and leadership unbeknown to a thoroughly ignorant society. His values, virtues, characteristics, and achievements in spreading Islam are in agreement with his status as a pure infallible. Yet, a very different perception of the Prophet exists among certain segments of the Muslim world. Instead of being seen as a God-appointed beacon of morality who led a previously blinded society to understanding and knowledge, Prophet Muhammad is viewed by these groups as a mere layman with many faults, whose sole purpose was to deliver the message of Islam.
Primarily led by Wahhabis and so-called "Muslim" scholars who ignore the Holy Qur'an, these Muslim detractors claim the Prophet, while relaying the message to the people of Arabia, continued to listen to music, questioned his own sanity, and at various points believed was capable of sinning too. Such traditions have been accepted as gospel by the ignorant and malicious propagandists of these incorrect sentiments. There are countless hadiths of this nature; in the interest of brevity, we will focus upon a few:
Doubting the Prophethood
Hammad ibn Salama said that the Prophet said, "I hear a voice and see a light and fear that there is some madness in me." (Al-Shifa, p. 284) This tradition, along with those found in al-Tabaqat Ibn Sa'd (Vol. 1, p. 225) and al-Tabari, indicate that Prophet Muhammad had serious doubts about his own divinely appointed prophethood. It is a recurring theme in many texts, including Sahih Bukhari Hadiths 6.478, 6.444 and 6.448 – portraying different versions of an event where the Prophet received a revelation from the Angel Jibrail and subsequently returned to his wife, Lady Khadijah, "scared". While such false hadiths have been refuted by several scholars, they remain prominent and insultingly enough are believed by some Muslims and used against the Prophet by non-believers.
Questioning his Infallibility
Sunni scholars approach the notion of sinless messengers and Prophets in one of two manners: either they contend that the Prophet became an infallible only after delivering the message of God, or they remain flawed human beings despite being Prophets. Shia scholars on the other hand believe that all prophets and messengers are infallible from day one of their lives and remain so until their death. Historically speaking, the Shia viewpoint in this regard has far more merit. However, the Sunni view is based on the idea that Prophet Muhammad listened to music and would sometimes forget prayer times and Qur'anic verses. (Sahih Bukhari p. 29; Vol. 4, p. 68 and p. 29; Vol. 4, p. 68)
These claims are in direct contradiction with the Holy Qur'an itself (verses 53: 1-4), and Shias believe that any Hadith which conflicts with the Holy Qur'an must be disregarded. What is the purpose of portraying the Holy Prophet as a "sinner" (God-forbid) if not to promote the malice and evilness of the Ummayads? By claiming the Prophet had sinned and was merely relaying the message and not implementing it, the scholars who purport such falsehood have lowered the standard for who should lead the Muslim world, thereby allowing incompetent and morally corrupt politicians to appear acceptable.
A Movement to Celebrate
Blessed and purified will the Prophet remain from the slanders inflicted upon him by so-called Muslims. Despite attempts from several interests to take away from the character of the champion of humanity, he remains the Seal of Messengers and the revolutionary figure that set mankind free with the message he brought. It is unfortunate that today there are those in the Muslim world who claim celebrating his birthday is an innovation and must be prohibited. Their actual purpose is to prevent us from believing there is reason to celebrate the Prophet's life, yet if there is ever a personality in all of history to celebrate and revere, it is none other than Prophet Muhammad. Our search for honor and virtue must begin and end by observing the shining principles of the life of the Seal of Prophethood. There is a profound fear among the enemies of God and His Messenger that if Muslims and non-Muslims were to discover the true essence of the Holy Prophet's traits and attributes, they too would become empowered to implement true Islam and humanity into their lives.
Islamic Insights
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6 Comments
Sister Huda,
Your article is very insightful and informative! You did a really good job showing the truth through your examples and wise words. :lol:
MashaAllah! I loved this article. So beautifully put. May Allah all guide us to the Truth and allow us to see the true essence of the Prophet (sawws) and his Ahlul Bayt (as). Ameen!
"Blessed and purified will the Prophet remain from the slanders inflicted upon him by so-called Muslims"

x100000. Brilliant article
I absolutely love this article and the timing for it was excellent asmany "muslims" still say its biddah to celebrate the Prophets birthday!
 :-)
I thought of bringing something to your notice before I begin reading your article:
The image representative of this article doesn't indicate the full salutation on the Prophet of Allah (SAWW). I had been accusing many other Muslims of making this mistake and since I am an avid fan of Islamic Insights and am really particular about what is posted here, I thought of correcting you too.

It has been narrated from the Holy Prophet himself that we should not send tailless salutation on him. I came across the following Sunni reference as I was surfing the web for a quick justification of my claim:

"The Messenger of Allah (SalAllaho Alahi WaAlehi Wasalam) said, "Do not salute for me in short!" The companions asked, "What is saluting in short?" The Prophet (SalAllaho Alahi WaAlehi Wasalam) replied, "Saying that Blessing of Allah be upon Muhammad." They asked, "what should we say?" the Prophet (SalAllaho Alahi WaAlehi Wasalam) answered, "Say: Blessing of Allah be upon Muhammad and his Ahlul-Bayt." In another wordings the Prophet (SalAllaho Alahi WaAlehi Wasalam) replied: "Say: O Allah bless Muhammad and his household the same way as you blessed Abraham and his household. Verily you are worthy of all praise full of all glory!".

Sunni reference: al-Sawa'iq al-Muhriqah, by Ibn Hajar, Ch. 11, section 1, p225

So please try to include "(SalAllaho Alahi WaAlehi Wasalam)" in all future references to the name of the exalted Prophet of Allah.

Thanks
love the article... thanks for such hidden info... may Allah bless u..
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Get the most out of your Droid's Android Daydream and Touchless Control features.
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Motorola and the stylized M logo, Maxx, M4DE MOTOROLA, and the Stylized M4DE MOTOROLA logo are registered trademarks of Motorola Trademark Holdings, LLC.
Android is a registered trademark of Google Inc. Droid is a trademark of Lucasfilm, Ltd. and its related companies. Used under license.
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This review is from: Griffin PowerDock Docking Station for Motorola Droid Mini, Droid Ultra, and Droid Maxx Desk Mode charging and syncing for Motorola
Pros: Weighty plastic construction feels nice out of the package. Packaging makes you think you've got something special.
Cons: Poor design, clumsy to use. Very disappointing product.
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It's okay
This review is from: Griffin PowerDock Docking Station for Motorola Droid Mini, Droid Ultra, and Droid Maxx Desk Mode charging and syncing for Motorola
Pros: Simple. Does what it purports to do.
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Posted: Sunday 27th April 2014
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Janine And The Mixtape – Hold Me x Pusha T [Official Audio + Video]
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Limestone College's Community Garden Celebration scheduled for April 15
Published: Wednesday, April 9, 2014 at 5:03 p.m.
Last Modified: Wednesday, April 9, 2014 at 5:03 p.m.
Even those without green thumbs can learn how to plant vegetables during Limestone College's Community Garden Celebration next week.
Hundreds of residents are expected to visit the campus starting at 5:30 p.m. April 15 to learn more about gardening and other green activities at the Community Garden, located off Griffith Street behind the Montgomery Hall, according to a written statement from the college. The event is free and open to the public.
"Not only is this event very educational, but it's also a whole lot of fun," Limestone's Felicia Cavallini, a physical education professor, said in the statement. "There will be music playing in the background, fun activities for the kids and learning opportunities for everyone."
Organized by Limestone's Physical Education Department, as many as 13 learning stations will be on display with various topics, including landscaping, pruning and gardening. There will also be a demonstration in the Community Garden, which currently contains cabbage, broccoli, onions, peppers, tomatoes and zucchini. Arborists Ernie Ramsey and Chad Phillips will host a "Hometown Arborists" station, and children may get their faces painted and learn how to plant seeds.
The Community Garden Celebration started in 2010 as a one-year project as part of a supplemental grant Limestone received from the S.C. Department of Health and Environmental Control. The inaugural year was so successful that Limestone officials opted to continue hosting the event, although scheduling conflicts prevented the event from taking place this past spring.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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All Comments for
Son Wants Mom Ch. 02byrictam©
- All
Comments (14)
- by Anonymous04/21/12by billyjim5504/21/12by peebudy04/21/12by digdaddyrich04/22/12by Eric_Shift04/24/12by LongTongue4205/01/12
Son Wants Mom This was even better than Pt1. Brendan getting to eat &
fuck mom like that,every son dream. LOVED mom sucking him clean after than awesome fuck,I hope he gets to fuck her ass too. What could ever top him cumming in her mouth,pussy & ass,it just doesn't get any better than that.YES I want him tongue fucking her more,rimming her ass getting it ready for his big cock. Let every readers fantasy about his mom come true.Let my fantasies come true. LTby LAROC11/13/12by Sex4lf5706/22/14by Anonymous12/08/14
short but sweet
Brendan's a very lucky boy. His mother Tammy opens her legs wide and teaches her son how to feast on the hole between her legs, the same hole he came out of as a little baby. But his mom's lucky too. At his age her boy's a nonstop semen producing machine. His young balls never quit. So in the space of about two hours, Brendan gives his mother three hot incestuous fucks, blowing his young balls and flooding his mother's cunt with his creamy semen. Now they know the truth of the wise old saying, "up his own mother's twat is where a boy's sperm belongs."by Anonymous09/17/15
Bedtime Reading
Im 39, and get real pleasure reading story's on this site, At moment I'm sitting on sette reading it out aloud to mother who is greedily sucking on my cock, she's 61 and I've been cocking her for years, we love your story keep up the good work, and now it's time to empty my balls, it's cunt o clock lol xby ledfoot196405/02/16
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Friday, July 19, 2013
1 Comments | Copyright: IANS
Pakistani actress Veena Malik says she has worn so many bikinis in her upcoming film "Supermodel" that she doesn't want to wear the two-piece garment ever again.
"The number of bikinis that I have worn in this film, I have never worn as many before. I don't even intend to wear a bikini again," the 29-year-old said here at the launch of the first look of the film.
"Probably this is going to be the only Bollywood film in which you will see me in a lot of bikinis. From now onwards, I have decided not to wear bikinis," she added.
Directed by Navin Batra, the film, shot in Fiji, also features Ashmit Patel as a photographer.
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