text:
The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells
The successful use of human embryonic stem cells (hESCs) as novel regenerative therapies for a spectrum of currently incurable diseases critically depends upon the safety of such cell transfers. hESCs contain roughly 3 million "jumping genes" or mobile genetic retroelements that comprise up to 45% of their genetic material. While many of these retroelements have been permanently silenced during evolution by crippling mutations, many remain active and capable of moving to new chromosomal locations potentially producing disease-causing mutations or cancer. More mature differentiated cells control retroelement movement (retrotransposition) by methylating the DNA comprising these elements. Strikingly, such DNA methylation is largely absent in hESCs because these cells must be able to develop into a wide spectrum of different tissues and organs. Thus, in order to protect the integrity of their genomes, hESCs must deploy an additional defense to limit retroelement retrotransposition. Recent studies of HIV and other exogenous retroviruses have identified the APOBEC3 family of genes (A3A-A3H) as powerful anti-retroviral factors. These APOBEC3s interrupt the conversion of viral RNA into DNA (reverse transcription), a key step also used by retroelements for their successful retrotransposition. We hypothesize that one or more of the APOBECs function as guardians of genome integrity in hESCs. We propose to compare and contrast which APOBEC3s are expressed in one federally approved and nine nonapproved hESC lines and to assess the natural level of retroelement RNA expression occurring in each of these lines. Next we will test whether the knockdown of expression of these APOBEC3s in the hESCS lines by RNA interference leads to a higher frequency of retrolement retrotransposition. Finally, if higher levels of retrotransposition are detected, we will examine whether these cells display an impaired ability to differentiate into specific tissue types corresponding to the three germ cell layers (ectoderm, mesoderm, and endoderm) and whether increased retrotransposition is associated with a higher frequency of malignant transformation within the hESC cultures. These studies promise to provide important new insights into how genomic stability in is maintained in hESCs and could lead to the identification of specific GMP culture conditions that minimize the chances of such unwanted retrotransposition events in cells destined for infusion into patients. These studies are directly responsive to the CIRM request for application. If funded, these studies would allow the entry of my laboratory with extensive APOBEC experience, into the exciting field of stem cell biology.
Harnessing the exciting potential of embryonic stem cells as therapies for a wide range of diseases like diabetes, Alzheimer's disease, myocardial infarction among others first requires ensuring that the infusion of these cells into patients can be performed safely. Of note, human embryonic stem cells contain up to 3 million "jumping genes" or mobile genetic retroelements that can potentially move from location to another in the genome. Great harm could occur if the movement of these retroelements in human embryonic stem cells results in the mutation of key genes or the inactivation of tumor suppressor genes, the latter could facilitate the development of cancer in recipients of these cells. The safety of stem cell therapy thus depends on the rigorous maintenance of genomic integrity and stability within the embryonic stem cell during its manipulation. Strikingly, the major cellular defense against the movement of the retroelements to new genetic locations, DNA methylation, is greatly reduced in human embryonic stem cells. A general state of hypomethylation is likely required to permit these pluripotent cells to differentiate into multiple cell types. With DNA methylation no longer able to constrain the activity of these retroelements, we believe a second natural defense springs into action to protect these stem cells. We proposeto identify and characterize this defensive network. These studies could lead to new approaches for maintaining or even enhancing this defense when embryotic stem cells are manipulated in culture, thereby helping to ensure the safety of embryonic stem cells destined for therapeutic transfer. Thus, the results of these studies will have both scientific and practical value. As such, we believe these studies will benefit the citizens of California certainly at a societal level and potentially at a personal level.
Human embryonic stem cells contain roughly 3 million "jumping genes" or mobile genetic retroelements that comprise up to 45% of human genome. While many of these retroelements have been silenced during evolution by crippling mutations, many remain active and capable of jumping to new chromosomal locations potentially producing disease-causing mutations or cancer. In tissues, mobility of these elements is suppressed by DNA methylation, which inactivates expression of the retroelement RNAs. In sharp contrast, embryonic stem cells exhibit very dynamic changes in DNA methylation, where the methylation patterns are gained and lost at high rates. During periods of low DNA methylation, retroelement RNA expression likely increases. Accordingly, hESCs must deploy other defensive strategies in order to maintain genomic integrity. Recent studies have identified the APOBEC3 family of genes (A3A-A3H) as powerful antiviral factors. These A3s interrupt the conversion of viral RNA into DNA (reverse transcription), a key step also employed by retroelements for their successful retrotransposition. We hypothesized that one or more of the APOBECs function as guardians of genome integrity in hESCs. In the last two years we have found that six out of the seven human A3 genes located in a tandem array on chromosome 22 are expressed in hESCs. A3A, which in prior studies was suggested to exert the greatest anti-retroelement effects, surprisingly is not expressed in hESCs. Further, we find that the A3 proteins decrease when pluripotent cells differentiate into somatic cells suggesting an important function of these A3 proteins in pluripotent hESCs. We established a LINE1 retrotransposition assay in hESCs that allows us to visualize genetic jumping of this class of "marked" retroelements via flow cytometry. Using this assay we have found that LINE1 elements effectively jump in hESCs. To test our central hypothesis, namely that A3 proteins guard the genome in hESCs, we have established experimental conditions for RNAi knock-down of all expressed A3 genes. By combining the knock-down and the retrotransposition assay we demonstrated that the knock-down of one member of the A3 protein family leads to a 3.5-fold increase in LINE1 retrotranspositon. This finding highlights a protective role for the A3 family of cytidine deaminases that helps safeguard the genome integrity of hESCs.
- J Biol Chem (2011) Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells. (PubMed: 21878639)
- Hum Mol Genet (2011) Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. (PubMed: 21989055)


text:
In Abu Nu'aym (Hilyat al-awliya', i, 355). Tawthiq by al-Dhahabi. 1
In his al-Khasa'is, p.95, from Muhammad ibn al-Muthanna (see 104). A leading scholar and traditionist.
In al-Tabarani (al-Mu'jam al-kabir, iii, Nos. 2680, 3052), from him, from Nasr ibn 'Abd al-Rahman al-Washsha' (see 129). The leading traditionist of Basrah during his days. 2
In al-Suyuti (Ihya' al-mayyit, 12), al-Sakhawi (al-Istijlab), al-Samhudi (Jawahir al-'iqdayn), Ahmad ibn al-Fadl ibn Ba Kathir (Wasilat al-ma'al), and al-Badakhshani (Miftah al-naja). A highly respected scholar. 3
In Ibn 'Asakir (Ta'rikh, i, 45), from Abu Bakr Muhammad ibn al-Husayn al-Mazrafi, from Abu al-Husayn Muhammad ibn al-Muhtadi, from Abu al-Hasan 'Ali ibn 'Umar, from him, from Zayd ibn al-Hasan al-Anmati (193). Tawthiq by al-Khatib. 4
In 'Ali al-Muttaqi al-Hindi (Kanz al-'ummal, xv, 19, xvl, 252, 253) from him, from Zayd ibn Arqam, Abu Sa'id al-Khudri and 'Ali (A). He is one of the greatest historians, exegetes and legists.
In his al-Dhurriyyat al-tahirah, 168 (Qumm, 1407) from Ibrahim ibn Marzuq, from Abu 'Amir al-Aqadi, from Kathir ibn Zayd, from Muhammad ibn 'Umar ibn 'Ali, from 'Ali (A). One of the leading traditionists and historians of his era.
In his Sahih, as mentioned by al-Sakhawi, op. cit. One of the imams of hadith.
In Ibn al-Maghazili (al-Manaqib, 234). Tawthiq by al-Khatib. 5
In his book al-Musnad al-sahih, as mentioned by al-Shaykhani al-Qadiri in al-Sirat al-sawi. A leading traditionist of his era. 6
In al-Tahawi (Mushkil al-athar, iv, 368), from him. A leading scholar of Iraq in his time. 7
In al-Tabarani (Mu'jam shuyukhih, i, 135) from him.
In al-Hamawi, Fara'id al-simtayn, ii, 272.
In his Mushkil al-athar, iv, 368, with two chains of transmission from Zayd ibn Arqam. A leading writer and scholar of his era. 8
In his Kitab al-du'afa' (MS. 362 in Dar al-Kutub al-Zahiriyyah, Damascus, F. 104) through three chains from Abu Sa'id and Jabir. A leading scholar of his age. 9
In his al-'Iqd al-farid. He is a well-known scholar of a high standing.
In his al-Masahif, from Zayd ibn Arqam and from Zayd ibn Thabit. An eminent scholar. Tawthiq and tasdiq by Ibn Khallikan and al-Sam'ani. 10
In his Amali, where he regards it as sahih, as mentioned by 'Ali al-Muttaqi in Kanz al-'ummal (xv, 122-123). A great scholar (imam) of Baghdad. 11
In his Kitab al-wilayah, known as Kitab al-muwalat, through 8 chains, as mentioned by al-Sakhawi (op. cit.), al-Samhudi (op. cit), Ibn Ba Kathir (op. cit.) and al-Shaykhani a1-Qadiri (op. cit). An eminent scholar of his era.
In al-Bayhaqi (Sunan, ii, 148) from al-Hakim, from him, from Muhammad ibn 'Abd al-Wahhab al-Farra' al-Abdi. Also in Ibn 'Asakir in Mu'jam shuyukhih (MS. F. 11). Tawthiq by al-Dhahabi. 12
In al-Bayhaqi (Sunan, vii, 30) from him, from Abu Ahmad al-Farra'. Author of a voluminous Musnad. An eminent traditionist from Nishabur.
In Abu Nu'aym (Hilyat al-awliya', ix, 64) from him, from Ahmad ibn Yusuf al-Dabbi. Teacher of Abu Nu'aym, who reports from Abu 'Umar al-Qattan that he saw 'Abd Allah ibn Ja'far in a dream after his death. When asked, "How did God treat you?" he replied, "He forgave me and put me with the prophets in their station." 13
In al-Hakim (al-Mustadrak, iii, 90) from him. Al-Hakim considers him thiqah and considers this narration of his as sahih.
In al-Bayhaqi (Sunan, x, 113) from Abu Muhammad Janah ibn Nadhir, from him, from Ibrahim ibn Ishaq al-Zuhri. Also in al-Hakim (al-Mustadrak, iii, 533) from him, where he, and after him al-Dhahabi in his Talkhis, has regarded it as sahih. The qadi and traditionist of Kufah. 14
In al-Hakim (al-Mustadrak, iii, 109-110) from him, from Zayd ibn Arqam. A leading traditionist and legist of his era and author of al-Musnad al-kabir.
In his book al-Talibiyyin, as mentioned by al-Sakhawi (al-Istijlab) and al-Samhudi (Jawahir al-'iqdayn). A leading scholar.
In his works al-Mu'jam al-saghir, al-Mu'jam al-kabir and al-Mu'jam al-awsat with different chains. One of the imams of hadith.
In al-Hakim (al-Mustadrak, iii, 109) from him, from Zayd ibn Arqam. A famous traditionist. 15
In his compilation of traditions (MS. No. 3637, F. 60, in Dar al-Kutub al-Zahiriyyah, Damascus) from Abu Sa'id. Tawthiq by Abu Nu'aym, Ibn al-Athir, Ibn Mardawayh, Ibn al-'Imad and al-Dhahabi. 16
In his Tahdhib al-lughah under 'itrah, as mentioned in Lisan al-Arab (iv, 538), and also under habl (Lisan al-Arab, xi, 137). A legist and leading philologist and lexicographer (imam fi al-lughah). 17
In al-Hakim (al-Mustadrak, iii, 109) from him, from 'Abd Allah ibn Ahmad. Al-Hakim has considered his narration as sahih. Tawthiq, also, by Abu Bakr al-Barqani. 18
In Abu Nu'aym (Hilyat al-awliya', i, 355) from him, from al-Hasan ibn Sufyan al-Nasawi. Also in al-Khwarazmi (Maqtal al-Husayn, i, 104) from 'Abu al-Ala', from Zahir al-Shahhani, from Abu Sa'id al-Ganjrudi, from him. Grammarian, legist and traditionist.
In Ibn al-Maghazili (al-Manaqib, 236) from Abu Talib Muhammad ibn Ahmad ibn 'Uthman, from him, from Zayd ibn Arqam. Tawthiq by al-Dhahabi, who calls him 'al-imam al-thiqah' and al-Darqutni, al-Safadi, and al-Suyuti. 19
In Ibn 'Asakir, Mu'jam shuyukhih, MS. F. 205.
In Ibn Ba Kathir al-Makki (wasilat al-ma'al, MS.) from him from Umm Salamah. A leading scholar and traditionist (imam) of his era, legist and expert on rijal. 20
In Ibn 'Asakir (Ta'rikh Dimashq, ii, 45). Tawthiq by al-Atiqi and al-Khatib. 21
In al-Hamawi (Fara'id al-simtayn, li, 272) from him, from Abu Sa'id al-Khudri. Tawthiq by al-Sam'ani. 22
In Manaqib Ahlul Bayt, MS.

subset: commoncrawl


text:
Our home decorating blog offers interior design tips and lighting ideas for today's home! Enjoy professional interior design advice, home decor ideas and inspiration.
LAMPS PLUS Blog Policies
The Cree 6" led retrofit module pictured at right converts most standard 6" recessed IC or non-IC housings into an LED light. It's a quick and simple installation and a great way to retrofit older recessed lighting.
The module is a twist-and-lock base, and will convert most standard recessed housings.
For more designs, browse all LED retrofit kits at Lamps Plus or review our entire collection of recessed lighting, including trim, housings, and new construction or remodel fixtures.
The design of bathroom hardware has taken off over the last year. There are a number of playful, contemporary look collections available, such as the Oops-A-Daisy collection. If that's too mod for you, you can turn to a classic chrome metal design or choose a high-end traditional look. Then it's time to update the towels!
Schoolhouse style lighting refers to a specific type of ceiling fixture that re-creates the look of lighting used in public buildings and schoolhouses in the early to mid-20th century. They most commonly refer to lighting with the distinctive "orb" glass.
Designers have been re-discovering these of late, as their styling blends well with both period and contemporary decorating. They look great in kitchen spaces or anywhere you need a clean, streamlined look.
Browse for other styles in our ceiling light collection.
One of the easiest ways to brighten and redecorate a child's room or play area is to add new floor covering. Doing so can instantly give a space a "theme", from sports to castles and princesses, and helps make the room seem fresh and re-decorated.
The new area rug designs for kid's rooms come in fun looks and bright colors, and come in a wide range of price points.
Kid's style area rugs.
The visual look of coral offers a vibrant, organic form for your home decorating.
We love the style on table lamps and table-top accessories, and it looks equally at home under-foot in the form of a bright area rug.
Coral-themed home decor and lighting.
We've noticed an increased commercial interest in LED applications, for example, in exterior lighting. Cities all over the world are exploring new ways of lighting their monuments at night. LEDs offer a highly efficient, colorful new approach. All of the possible applications are still being explored. To see this trend in action, check out the photos from the links below:
Prospect Park; Brooklyn, New York
Entel Tower; Santiago, Chile
You can read more about the considerations and planning that goes into lighting our Washington D.C. monuments here.
Thomas Alva Edison was born today, February 11th, in 1847. The electrical systems that we have today are based on the same functionality that Edison patented and explored throughout his career so it is a special day for those of us in the lighting field. I wonder what he would make of our modern world with all of its gadgets and technical advances...
Browsing through the site today I came upon this Bickett Tobin red mini blossom table lamp. The hand-sewn silk shade reminds me of the colorful lanterns used to celebrate the Chinese New Year.
The red color of the lanterns is believed to lucky. Who doesn't need more luck in the coming year?
Haute couture fashion icon Oscar de la Renta has added a line of elegant table lamp designs to his fashion empire.
The sophisticated looks have a luxurious and urbane sensibility, and are the perfect accents for adding a little style sizzle to your home decorating.
Oscar de la Renta table lamps.
UPDATE 10-1-08: We apologize, but Oscar de la Renta lighting designs are no longer available at this time. We invite you to browse our designer lighting page to find other name brand designs.
Act like a gourmet chef by adding a pot rack chandelier. These specialty chandeliers add handy storage space, plus are a great option for keeping cooking pots close at hand. With their built-in lighting, they're also a great solution for smaller kitchens.


text:
Currently Shopping by:
Shopping Options
You have no items to compare.
Wednesday, May 18, 2016 9:05 AM
I've always been curious about macarons, and recently I got the opportunity to try them for the first time...
Wednesday, May 11, 2016 2:05 PM
You may not realize it, but there are many objects around us ready to be repurposed into something new. If...
Wednesday, May 04, 2016 1:05 PM
One of the first products developed at Poly-Wood was the Classic Adirondack – it's actually our #1 selling...
Poly-Wood, LLC, (hereinafter "Poly-Wood"), warranties to the original purchaser ("Purchaser") that, for a period of twenty (20) years for residential use and one (1) year for commercial use from the date of original invoice, under normal use and service conditions, POLYWOOD® brand high-density polyethylene (HDPE) products shall be free from material defects Learn more »


text:
J.D., University of Virginia School of Law, 1977
B.A., University of Virginia, 1970
University of Virginia alumnus Michael Ross teaches the short course "Ethics & Integrity for Law Firm Lawyers and Business Clients" at the Law School. He taught at the University of California Berkeley School of Law, where he was a member of the Advisory Board of Berkeley's Center for Law, Business and the Economy, from 2001 to 2012. He also teaches a seminar, "Managing Legal Risk in Business," in the LL.M. program at the IE Law School in Madrid. From 2001 to 2012, he served on panels on numerous topics, such as mergers and acquisitions, directors and officers liability insurance, corporate ethics, legal risk management, special investigations and antitrust for Stanford Law School's Directors' College. He is a member of the advisory board of UVA's Institute for Practical Ethics and Public Life. Ross is also a member of the Affiliated Transnational Faculty of Peking University's School of Transnational Law, and an adjunct consultant with Altman Weil, Inc. He has addressed law firms about the relationship between outside counsel and client, and corporate law departments about managing outside counsel. He was a regular columnist for "GC California," an American Law Media publication. His textbook, Ethics, Integrity, and Avoiding "Club Fed," published by LexisNexis in 2011.
Ross was senior vice president, general counsel and secretary of Safeway Inc. Beginning in 1993, he was responsible for Safeway's legal affairs in the United States and Canada, as well as security, risk management and environmental health and safety. Before he retired as an executive officer in May 2000, Ross successfully managed Safeway's acquisitions of The Vons Companies, Inc. (1997), Dominick's Supermarkets, Inc. (1998), Carr-Gottstein Foods, Co. (1999) and Randall's Food Markets, Inc. (1999).
After his retirement as an executive officer, Ross served as senior advisor to Safeway, managing its proposed acquisitions and divestitures, including the successful acquisition of Genuardi's Family Markets, Inc. in 2001. Prior to joining Safeway, Ross was a partner at the law firm Latham & Watkins, where he specialized in corporate mergers and acquisitions. He served on the recruiting committee and as chairman of the finance committee.
Ross graduated from the University of Virginia School of Law l in 1977 and received his bachelor's degree with honors from the University of Virginia in 1970. He served in the U.S. Navy from 1970 to 1974, completing the last two years of service as a lieutenant and the operations officer of the U.S.S. Truckee.


text:
Property Information
|Location: tola-coast
|Community: popoyo
|Property Type: Hotel
|Bedrooms: 1
|# of Beds: 3
|Bathrooms: 1
|Sleeps: Up to 5
Regular Season:
Soma (South of Managua) lies in the heart of the best surf breaks Nicaragua has to offer!
Experience Popoyo, Santana, Colorado and Astillero. There are a variety of point and beach breaks for surfers of all ability levels. Custom guided tours are available and can be designed for individuals or small groups.
Soma offers private bungalows and deluxe rooms:
Private Bungalows (sleeps 3-5): $120/night
- Two double beds made from exotic local woods
- One convertible comfortable twin bed
- Walk-in master shower with hand made local stone
- Double vessel twin sinks
- Polished concrete floors
- Air conditioned through-out
- Stainless steel industrial fans/high ceilings
- High quality linens and towels
Deluxe Rooms (sleeps 3): $90/night
-Three superior twin beds with pillow top mattress
-Beds made of local exotic woods
-Walk-in shower with hand made local stone
-Vessel sink
-Polished concrete floors
-Air conditioned through-out
-Stainless steel industrial fans/high ceilings
-High quality linens and towels
Soma Surf Resort is an upscale, but simple and elegant resort set in the hills of Tola, 10 minutes from some of the best surf breaks in the world. And the hosts, Casey and Bill Morton, will make your stay perfection. The on premises restaurant offers some of the best food in the area, and they will even insist you take a ride to the beach with someone from their staff to purchase the daily fish offering freshly caught, a must-do when visiting Soma.
Definitely a great place to visit and chill out, and ladies, if your man is looking to go surfing and you are worried about having nothing to do while he is out in the water, this is the place for you!
Nestled among the greenest mountains in Playa Gussacate is Soma Surf Resort.
Soma is the amazing creation of Casey and Bill Morton, who are truly committed to every need of their guests.
We just returned from 5 fantastic days where my 15 year old son was able to surf all the different famous surf spots, and chase after the waves with his surf guide. I, on the other hand, prefer the 2 feet on land, was able to sightsee and relax by the gorgeous by pool overlooking the exquisite landscape that Soma offers.
I left there feeling terribly spoiled, as every need and whim was met by the local staff, as well as inspired by the amazing talent and dedication of the owners at Soma.
Already planning our next trip back!
Something for every family member!
- High quality bath towels and linens (bring your own beach towels)
- wifi
- On-site restaurant
- Pool
- Private driver upon request
- Board Rentals available by request
There are several transportation options once you arrive in Nicaragua. In the dry season (Nov. - May), you can often get by with a taxi or shuttle to the Tola area. In the rainy season (June - Oct.), a 4wd vehicle is recommended. Nicaragua has all the major rent-a-car companies at MGA International and reservations can be made in advance, online or upon arrival. If you decide to drive on your own, please be aware that Nicaragua has regular police checkpoints. If you prefer not to drive, we can arrange private transportation for you and your group. We operate a fleet of vans and 4wd vehicles which will can accommodate airport transfers and daily trips. Please also note that a private driver is available upon request of you would like to rent a vehicle, but prefer not to do the drive yourself.
Groceries and Restaurants
Although soma is in a rural and somewhat isolated setting, you will be pleasantly surprised by the variety and flavor of the food served at Soma's on-site restaurant. Soma concentrate's on local foods, including fruits, vegetables, fish, beef and chicken, with an emphasis on pairing great tastes with tantalizing recipes for nourishing and satisfying meals.
Soma's full service restaurant serves fresh fare with a distinct flavor using natural ingredients where you will truly savor the "farm to table" experience.
Meal Plan
- Surfing
- Fishing
- Snorkeling
- Horseback riding
- Golf at Hacienda Iguana
- Fun local restaurants
- Yoga
- Visit the Las Salinas Hot Springs
- Beach Combing
- Sunset beach walk
Side trips for:
- Shopping in Masaya
- Visit Granada
- Check out San Juan Del Sur
- The island of Ometepe


text:
Integrate asset-related data, processes, and analytics for effective maintenance operations using our software. Gain visibility and control to minimize downtime and maximize profitability. Shift to a proactive, structured approach to procedures and master data. Enforce service levels and optimize maintenance activities.
Read how this Canadian chemicals company has improved maintenance operations, management, and collaboration – while cutting related costs and sustaining world-class uptime. Nova Chemicals has increased preventative maintenance by 61% and reduced reactive, emergency, and ad- hoc repair efforts by 47%.*
Integrate and automate all maintenance-related data, processes, and reporting with software solutions from SAP and our partners. Gain the visibility and control that you need to minimize downtime, keep assets profitable, enforce service levels, and optimize maintenance operations activities.
If you're in the process manufacturing industry, explore how to run better using business analytics software solutions from SAP. The benefits of improving visibility across maintenance and other operations add clarity for compliance, efficiency, and profitability. Gain insights on planning for success.
Want to learn more about these SAP solutions?
Revitalize resource scheduling and dispatching processes to deliver services faster, at lower costs. Gain real-time insight into resource usage.
Use a risk-based approach to plan, approve, prepare, execute, and complete maintenance operations. Enforce compliance with safety procedures for hazardous work.
Boost reliability, efficiency, maintainability, and safety of linear assets – including roads, rails, pipelines, and electricity transmission lines.
See how effective your project management can become when you can efficiently access the right information – with our powerful project management software.
Mobilize service technicians – so they can manage work orders, notifications, and inventory in the field – with our mobile enterprise asset management software.
*All implementation results are for informational purposes only and the examples provided while based on actual SAP customers' experiences do not represent commitments or guarantees by SAP and/or its partners. Actual pricing, costs, and implementation results may vary, based on customer-specific requirements and needs. The only warranties for SAP products and services are those that are set forth in the express warranty statements accompanying such products and services, if any. Nothing herein should be construed as constituting an additional warranty.


text:
|Eligible for Free Shipping on Orders $39 or More! (see promotion details)
Product Details
Keep yourself prepared for anything with the GERBER® Splice™ black mini scissors keychain tool. Featuring a variety of handy accessories, this miniaturized multi-tool kit includes all the knives, files, screwdrivers, and can openers you need to come to a friend's rescue at any moment.
Get your new GERBER® keychain tool today from Sports Authority.
- Multi-tool mini-scissors
- Keychain compatible
- Stainless steel
- Includes: Bottle opener, file, lanyard ring, serrated knife, fine-edge knife, Phillips screwdriver, and 2 flat screwdrivers
- Lightweight and strong
- Overall Length: 4.00 inches
- Closed Length: 2.40 inches
- Width Open: 3.50 inches
- Width Closed: 1.00 inches
- Blade Length: 1.50 inches
- Weight: 2.50 ounces
- Manufacturer's lifetime limited warranty
Product Recommendations
Product Reviews
Reviewed by 2 customers
Sort by
Best Uses
Comments about Gerber Splice Black Mini Scissors Keychain Tool:
Genuine Metal that is sharp and can cut through many things! Easy to use and very in depth description of all the available tools.
- Comfort vs Style:
- Comfort Driven
Best Uses
Comments about Gerber Splice Black Mini Scissors Keychain Tool:
I ordered by the picture (my mistake) but the description is a different thing. It is showing a SOL knife but the knife that you will get when ordered is a Gerber tool. Customer service told me to keep it and money would be refunded but when I wasn't refunded I called and was told to return it..
- Was this a gift?:
- No


text:
Derivation and characterization of human ES cells from FSHD embryos
Facioscapulohumeral muscular dystrophy (FSHD) is the third most common hereditary muscular dystrophy. It is autosomal dominant, meaning that if one of the parents has the disease, their children have a 50:50 chance of getting it, too. FSHD is characterized by progressive weakness and atrophy of facial, shoulder and upper arm musculature, which can spread to other parts of the body. In some cases, it is accompanied by hearing loss and, in severe cases, mental retardation. There is no cure or treatment of this disease since the gene(s) responsible for this disease has not been identified. One thing that is clear is that the majority of FSHD is linked to a decrease in the number of repeats of a DNA sequence called D4Z4 located at the end of chromosome 4. When shortening of this repeat region occurs in either chromosome 4, the person gets FSHD. However, it is unclear how shortening of this repeat leads to the disease. We found that this D4Z4 repeat cluster contains "heterochromatin" structure, which is associated with gene silencing. This heterochromatin structure includes specific methylation of histone H3 and the recruitment of heterochromatin binding proteins HP1 and cohesin. HP1 is known to be required for gene silencing. Importantly, we found that this heterochromatin structure is uniquely lost in FSHD patient cells. Surprisingly, the minor population of FSHD patients who do not exhibit any repeat shortening also lack this heterochromatin structure in the D4Z4 repeat on chromosome 4. Therefore, FSHD is a "heterochromatin abnormality" disease, in which loss of heterochromatin at D4Z4 repeats leads to disease manifestation. We hypothesize that the normal heterochromatin structure spreads silencing effects on to other genes, but in FSHD this effect is lost and these genes that are normally silent may be abnormally expressed. Since we found that this heterochromatin structure is already established in embryonic stem (ES) cells under normal circumstances, it is of vital importance to examine this process in FSHD ES cells. This would be important to understand how heterochromatin establishment is compromised during development and, as a result, which genes are affected. However, no FSHD ES cells are currently available. Generous and courageous families with FSHD in their history donated in vitro fertilized embryos for research use in the hope of improving the life of FSHD patients in the future. Therefore, our major goal is to establish FSHD ES cell lines not only for our research, but also for use in the FSHD research community. We hope to optimize a protocol to differentiate these cells into skeletal muscle cells for a comparative analysis between normal and FSHD ES cells during development. I believe that the proposed project will make significant contributions to understanding the etiology and pathogenesis of FSHD as well as to possibly develop therapeutic strategies to improve the physical functioning of FSHD patients.
Facioscapulohumeral dystrophy (FSHD) is the third most common hereditary muscular dystrophy in the United States. California is the most represented state in the U.S. in terms of membership in the FSH Society. Almost 250 families in California with an average of 3-4 affected members per family belong to the FSH Society, which would translate to 750 to 1,000 total registered patients. FSHD is reported to have a 1 in 20,000 incidence. However, the Society estimates that the actual incidence is probably considerably higher, with a likely incidence of 1/7,000. This higher estimate is based on clinician expert opinion that FSHD is at least three times more prevalent due to misdiagnosis, which reflects the difficulty associated with recognizing those patients with a mild clinical disease presentation. This is consistent with the opinions of some people who track FSHD cases that improved molecular diagnostic techniques will give a more accurate assessment of the full range of this disease in the population. Since this disease is dominantly inherited, a large family can have a significant number of affected individuals. In one documented case a family of 2,500 people traced to a settler who had FSHD had1600-1700 affected members, many of whom ultimately moved to California. Many families affected by this disease are reluctant to come forward to seek help, and therefore are not included in the membership rolls of the FSH Society. FSHD is not necessarily lethal and many patients must live and cope with progressive disability during their lives without any effective treatment. There is no effective treatment because the disease mechanism is unclear. The fact that the upper limbs are predominantly affected suggests that the abnormality may be initiated during embryonic development. Thus, the proposed project to obtain FSHD ES cells is critical for studying this crucial time point in manifestation of the disease. We plan to make these cells available to scientists in the FSHD field to further facilitate investigation of many different aspects of FSHD pathogenesis. We also hope that these cells become valuable reagents for development of better molecular diagnostics as well as fostering new ideas concerning possible treatment strategies. The primary goal is to offer new insight into improving the lives of the many FSHD patients in California and across the international community.
Facioscapulohumeral muscular dystrophy (FSHD) is the third most common hereditary muscular dystrophy. There is no cure or treatment for this disease since the disease mechanism is not understood. We found evidence that FSHD is a "chromatin abnormality" disease, in which specific histone methylation and factor binding affecting gene silencing is lost at specific genomic regions. We hypothesize that the chromatin structure important for gene regulation is compromised in FSHD. Since we found that this chromatin structure is established in normal human embryonic stem (hES) cells, it is critical to examine how this process goes awry in FSHD during differentiation of hES cells into skeletal muscle cells. Therefore, our major goal is to establish hES cell lines from affected and normal embryos and to optimize a protocol to differentiate hES cells into skeletal muscle cells for comparative analyses. This is not only for our research, but also for use in the FSHD research community, which should help to understand the etiology and pathogenesis of FSHD as well as to possibly develop therapeutic strategies. During the past one year, we continued to optimize skeletal myoblast differentiation from hES cells by using several different protocols. While we were able to detect expression of muscle lineage-specific marker genes (i.e., Pax7 and MyoD) during ES cell differentiation, the expression level remained low and we continue to investigate different protocols for better gene induction and enrichment of the proper cell population by cell sorting. It is essential to attain a sufficiently high density of derived myoblasts in order to allow them to form myotubes, which is the basic fundamental element of skeletal muscle. The very recent publication (i.e., June, 2009) of a detailed protocol for derivation of skeletal muscle cells from hES cells should be of great assistance to us, as it highlights several key factors that are likely to be crucial for success. In addition, we have acquired with proper hSCRO approval the first batch of embryos of seven donated by an FSHD patient donor. Out of seven embryos, we have thawed five embryos initially and followed their growth in culture dishes. However, these embryos were frozen five years ago under suboptimal conditions, and failed to further develop in culture for us to derive any ES cells. We are in the process of thawing the remaining two embryos, although similar problems may persist. Presently, we have identified two additional sources of FSHD embryos. The acquisition process has been considerably prolonged due to recent changes in NIH regulations that necessitated the modification of the consenting form and process. However, with the help of our collaborator from Scripps, Dr. Jeanne Loring, we are in the process of obtaining five additional embryos and we have requested a "no cost" extension of this project in order to complete the derivation of hES cells from these embryos. During the past year, we published our initial characterization of the chromatin structure in FSHD patient cells by comparison with normal cells of different cell types, including hES cells. We detected differences in how one of the histone proteins is chemically modified in certain regions of the genomes in normal versus FSHD cells. This is important since histone proteins not only help to package DNA to form the basic element of chromatin, they also play a huge role in controlling gene expression. Since the effects of FSHD likely result from abnormal regulation of expression of certain genes, our work identified a relevant chromatin "marker" which is potentially useful for diagnostic purposes. In addition, our findings define a way to follow any changes in target gene regulation during the differentiation process (i.e., hES cells to myoblasts and myotubes) in normal and FSHD hES cells. The published manuscript was selected for "Faculty of 1000", and we have already been asked to write a review on this subject. Furthermore, we have obtained NIH R01 funding for further high-throughput analysis of chromatin structure in FSHD. Taken together, with the support of the CIRM SEED grant, we are moving forward to understand the chromatin abnormality during cellular differentiation linked to FSHD pathogenesis.


text:
I just got done making a one day project of turning a mall map into a medieval harbor town. I might add more to the map like color in rooftops and make a cartoon map of a fictional medieval harbor town. I decided to keep the name of the mall as the name of the town. The map was from Westfield Galleria in Roseville, CA. I have a couple of other mall map villages I plan to finish since it's too hot here to keep my hands draw to work on my paper projects.
The shape of the town suggests that the main street runs along a valley, so I think I'm going to work with that idea. I'm using MS Paint for this project wince it's the only image editor I have. I might redraw this on paper once the weather cools here later in the year, but that won't happen until the end of October.
I guess I will make a history for this town. It came out looking so real too. I think mall maps are going to be a good source of layouts for small medieval towns.
Looking good so far darkseed, nice job on the lighting (did you use bevel and emboss or did you manually shade the roof tops?). One thing that kind of sticks out however is that some of the lines in this map look fairly pixalated. Not too familiar with MS paint so I don't know what to suggest in order to fix it unfortunately.
Yes, that update is looking nice. I am guessing the roof colouring was done manually.
The pixellation is obvious, I agree, but that isn't necessarily a bad thing. You could try and smooth it out or just leave it for that sort of 8-bit or artificial look. It all depends on the style of image desired.
I looked up Westfield Galleria just to compare it to the mall layout. It's pretty faithful! One of the more unique sources of map inspiration I have seen here!
Everything is being done manually. MS Paint is only the most basic drawing program and it comes with the PC. Normally I never do maps using a computer, but I thought I would give it a shot. I am limited in software options because of the age of my computer, so I think I will work with the 8-bit look. I'm not sure what to do with it, but I am thinking of drawing it on paper at a later stage, because I like the shape of the town and its proportions, something about it hit that sweet spot.
I think the food court ended up being the town square. I never actually been to this mall, but the layout really worked for a harbor town. I have other mall maps, but I think this one is going to get the most attention.
I'm going to stop for the night. The more i fill in, the more I like the 8-bit look. It really works for this. It will be cool to have it redrawn with a vectoring software. Wording is going to be the hardest part. I have no idea how I will do that since MS Paint only types right to left. I guess this could be a village anywhere in Europe. I have no facades showing on this map. The bay has a Mediterranean feel to it. Let's say the town is in Italy or France.
I'm thinking of adding trees to the map, but at this time, I'm done with it. I like how it came out. I'm not so sure if the bluffs came out right. I'm thinking strongly of doing a paper version when I complete the Zigoto map I was working on. I really like how the town's buildings look.
If anyone wants to make a better version, feel free to do so. I'm going to make one more update, which will label the important buildings. I still have to decide what my town will do and what industry will be there.
I like how it's turned out. It might be worth altering some of the "plots" to take into account the ridges though.
It would be a lot of work to get it right, since the map was made in two layers. MS Paint allows white areas to be transparent, but at this time, I think I'm done with working on it. Right now I'm trying to find a way to label buildings, so it can be remade for a game or something. The editing tools I have available made very crooked looking text.
I tried labeling with AutoRealm since it's the only thing I can get on this computer. Once I figure out the program I'm going to label the map.


text:
A Hamilton County budget shortfall could force officials to cut more than 300 county jobs, according to Hamilton County Administrator Christian Sigman. If the county doesn't fix its problems, it could fall into "fiscal emergency." Officials are worried some cuts could jeopardize functions required by state law. A recent study found that the national unemployment rate would be at 7.1 percent if it wasn't for government job cuts.More than $85 million has been awarded to local transportation projects by the Ohio-Kentucky-Indiana Regional Council of Governments. The funding will go to Metro buses, roads, traffic signals and more.
City Councilmember Charlie Winburn, the lone Republican on City Council, is thinking about running for mayor in 2013. Mayor Mark Mallory is currently serving his last term, so he will not be able to run again.
Ohio Secretary of State Jon Husted said he is considering establishing uniform early voting hours statewide. Recently, Democrats have been accusing Republicans of a statewide conspiracy to extend voting hours in Democratic counties and shrink voting hours in Republican counties.
Ohio was the 13th fattest state in 2011, according to a new report from the Center of Disease Control. Fortunately, Ohio managed to stay under a 30 percent obesity rate, unlike the 12 fattest states.In the future, Ohio will be the ninth worst state to live in, according to a new Gallup analysis. Ohio still beat Kentucky, which ranked third worst. Not so fortunately, Utah topped the ranks. I've been to Utah, and I prefer Ohio. I don't trust your math, Gallup!
Ohio Treasurer Josh Mandel, a Republican who is also running against Democratic Sen. Sherrod Brown for U.S. Senate, is scheduled to appear with presidential candidate Mitt Romney today. Mandel is also famous for earning the "Pants on Fire" crown from Cleveland's The Plain Dealer for his excessive lying in campaign ads.
The Medicaid expansion does not have to be permanent, according to federal officials. States can expand then scale back, although it will cost federal funds. Medicaid expansions have been proven to save lives and boost health, but Gov. John Kasich is still undecided about the expansion.
The Cincinnati Museum Center earned top accreditation.
Unmanned drones could soon be flying in domestic skies.
Anybody who's familiar with the Internet knows that it's a great place for looking at pictures of people without their clothes.
Apparently a lot of people want to do that to vice presidential candidates as well.
According to Google Politics & Elections, the No. 2 most-searched term connected to Wisconsin Rep. Paul Ryan's name is "shirtless."
Ryan is known for a proposed budget that would offer massive tax cuts to the rich while attempting to reduce the deficit by gutting Medicare.
If one is to believe TMZ's absclusive titled "Paul Ryan: He's Hiding A Six Pack," then one could see why.
An intrepid CityBeat intern spent most of Monday morning searching for pictures of said abs, but was only able to turn up the vice presidential candidate waving ironically from his yacht.
According to TMZ's unnamed Hill source, Ryan hits the gym every morning at 6 a.m., and his routine is "fierce." The source, who talks like a stereotype, says Ryan is kind of on the skinny side, but "totally ripped and has a six pack."
Ryan's press camp responded to the news by challenging Joe Biden to a sit-up contest in lieu of a vice presidential debate.
Google's top four related search terms for Paul Ryan:
Presidential candidate Mitt Romney announced his running mate Saturday: U.S. Rep. Paul Ryan. Ryan is currently the chairman of the U.S. House of Representatives Budget Committee. He is known by many Republicans as an "intellectual" in the party. He is known by everyone else as the guy who tried to dismantle Medicare. Ryan is also a Miami University graduate, and he was once a staffer for now-Gov. John Kasich when Kasich was still a congressman.
State Rep. Connie Pillich, a Democratic House member for suburban Cincinnati, is facing a tough campaign for re-election against Republican Mike Wilson. One of the reasons the campaign is more difficult for Pillich this time is the redistricting process was used to redraw her district to favor Republicans.
Hamilton County is going to be holding eight budget forums. The forums give the public an opportunity to discuss what they think should be prioritized and slashed in the next Hamilton County budget.A new report found the 2020 Cincinnati jobs market will be dominated by health care and computer jobs as the city continues its strong growth. The report also found a surprising amount of top jobs will only require a high school diploma or an equivalent to a high school diploma.
The Coalition Opposed to Additional Spending and Taxes (COAST) is continuing its dishonest campaign to block the Blue Ash Airport deal, but Cincinnati and Blue Ash lawmakers don't seem too worried. At least COAST admits it's largely interested in blocking the streetcar "boondoggle," not just the legitimacy or details of Blue Ash rescinding the original deal. CityBeat previously covered the Blue Ash Airport issue here.
The number of Ohio homeowners late on mortgage payments rose in the second quarter, according to a new report. The rise reverses a trend of dropping mortgage delinquencies seen earlier in the year.
The Complete Ohio College task force will be meeting for the first time today. The group is meant to increase the amount of college degree holders in Ohio.
The Brookings Institute released a study that shows unemployment would be at 7.1 percent without cuts to government job.
Romney has called for a truce on his business record and tax history. Apparently, Romney wants to focus on issues, even though he's the one that has repeatedly brought up his business record time and time again. Seriously, is this real life?
Speaking of Romney, he will be in Ohio Tuesday.
President Barack Obama takes the old saying "an apple a day keeps the doctor away" really seriously.
Here is a turtle with a mohawk.
Ohio Secretary of State Jon Husted announced today that there is a new way for registered voters to change their voting address: the Internet.
If the state had done this in 2008, about 130,000 provisional ballots could have been cast as regular ballots, according to Husted. Provisional ballots are ballots used to record a vote when there are questions surrounding a voter's eligibility. Provisional ballots are sometimes discounted if a person fails to prove his/her eligibility to vote.
"This added convenience for voters is also a powerful tool against voter fraud as current and accurate voter rolls leave less room for abuse," Husted said in a press release.
Husted said the new system will also save tax dollars. For each registration done online instead of by mail or in-person, the state saves money.
The website requires four identification keys: a last name, an Ohio driver's license number, the last four digits of a Social Security number and a date of birth. Registered voters that supply this information will be able to submit an application for an address change.
Applications will be reviewed by county election boards. If the address change is accepted, the election board will send an acceptance letter by mail to the new address.
The state is working heavily with the Ohio Bureau of Motor Vehicles to share voter data. At this time, more than 6 million of Ohio's registered voters will be able to change their addresses online.
To change an address online, voters can visit the Ohio Secretary of State page at MyOhioVote.com. Anyone who registers between now and October will also be put in a line to receive an application to vote by mail for the November elections.
Faced with the choice of raising property taxes or funding senior and mental health services at their current levels, the Hamilton County Board of County Commissioners voted on Wednesday to approve a ballot measure that would effectively cut tens of millions of dollars from those services if passed by voters.
"It seems wrongheaded for us to ask citizens to pay more in taxes when their homes are worth less, when costs have gone up in their households and when in many cases their paychecks are down," said Board President Greg Hartmann. "So we need to hold the line on those property taxes."
The tax rate would be held at the levels passed by voters in 2008, which would be an effective reduction due to declining property values. If Hamilton County voters approve the levies in November, senior services would see a $7 million reduction in funding over the next five years — down to $97 million from $104 million — while funding for mental health services would fall $17 million from $187 million to $170 million, Hartmann said.
The money funds services such as meals on wheels, in-home care for seniors, counseling and drug and alcohol addiction and treatment services.
The board's sole Democrat — Commissioner Todd Portune — made the symbolic gesture of submitting an alternate proposal which would have funded services at the levels providers had requested, but it failed without support from either of the board's two Republican members.
Portune's resolution would have increased property taxes by $5 for every $100,000 the property was worth. He said voters should be given the option to shoulder the additional tax burden. He later voted in favor of Hartmann's resolution, saying the worst thing that could happen would be for voters to approve no levy.
Commissioners also approved a resolution to formally review all healthcare services provided by the county in hopes of saving money by eliminating any that were duplicated at the federal level under the healthcare overhaul.
Hartmann said he didn't come to the decision to keep the levies at the current rate lightly and pledged to work with the recipients to manage the reduction.
Many of those providers appeared at three public hearings held in the last month and with near unanimity asked commissioners to approve the increased rates — which would have kept funding even by countering the money lost from decreased property values.
Patrick Tribbe, president and CEO of the Hamilton County Mental Health and Recovery Services Board, didn't outline specific cuts the agency would undertake, but told reporters after the commissioners' vote that he would spend the next six months planning for the start of the next fiscal year, when the cuts would take effect.
The Tax Levy Review Committee had recommended that the property tax rate remain flat instead of increasing. It suggested that service providers reduce their administrative costs and find areas to increase efficiency.
Many of the providers who spoke at the public hearings said they had already cut administrative costs about as deeply as they could and had very little room for to cut further.
Touts Mandel's Ability To Consistently Repeat Previously Debunked Lies: "Us Serial Liars Need To Stick Together"COLUMBUS, OHIO – The Boy Who Cried Wolf announced his endorsement of Josh Mandel today, ending speculation about who the world renowned liar would support in the Ohio senate race this November. "Josh Mandel shares my ideals, my values and most importantly my less-than-casual relationship with the truth," said the Boy Who Cried Wolf. "Us serial liars need to stick together, and now that Josh Mandel's officially been crowned King of Ohio's Liars, the choice for me is simple. I'm honored to support Josh and I look forward to joining him and his special interest friends on the campaign trail as they lie about Sherrod and distort his record on the issues from now through November." The Boy Who Cried Wolf rose to fame for repeatedly proclaiming that his sheep were being attacked by a wolf, when in fact, no wolf had attacked his sheep. Much like the Boy Who Cried Wolf, Josh Mandel's star has risen largely because of his penchant for repeating previously debunked lies. This week Josh Mandel earned the "Pants on Fire crown" from Politifact Ohio, an award reserved for the worst liar among all Ohio politicians. ### Paid for by the Ohio Democratic Party, Chris Redfern, Chairman
The new College Hill office will be the source of phone calls and canvassers to the Mount Healthy, Northside, North College Hill and College Hill neighborhoods. The Obama campaign already has field offices in East Walnut Hills, Cheviot and Forest Park.
Obama's Republican rival Mitt Romney's campaign has three offices: in Kenwood, Westwood and Colerain. Staff contact Kelsey Romanchik said she didn't know if there were plans to open more.
More than 150 people braved the sweltering Cincinnati humidity for the opening of the Obama College Hill field office. They were greeted by a drum line outside of the office, as well as inside a mainstay of any such campaign event — snacks.
Keynote speaker City Councilman Cecil Thomas sounded off many of the Obama campaign's talking points, attacking Romney's tenure at Bain Capital, his refusal to release further tax returns and Romney's tax plan, which a recent study by the Tax Policy Center says will raise taxes on the middle class by eliminating popular tax credits.
"Why in the world would I vote for someone like that?" asked Thomas.
Cincinnati voters will decide in November whether to double the length of their council members' terms.
City Council voted 6-3 on Wednesday to put the ballot initiative before voters. The measure would have all nine members run at the same time, instead of a competing ballot initiative that would have staggered their terms.
"We are the only major city in Ohio that still has two-year terms for its leaders, and the cities that we compete with are also moving to four-year terms, including Louisville and as far as St. Louis, Minneapolis, Denver and Atlanta," said Councilwoman Laure Quinlivan, who spearheaded the effort.
If approved by voters, the change wouldn't affect council members serving currently and would go into effect in 2013.
Not every council member was thrilled with the idea.
"I think accountability is paramount, and I don't see going from two-year terms to four-year terms as increasing the accountability citizens want," said Councilman P.G. Sittenfeld, who was one of three new faces to join council in last year's election, which saw four Republican incumbents booted from City Hall.
"I'm sure it's not lost on my colleagues that last November the electorate was craving change and wanted change, and if we had been in the middle of a four-year cycle they wouldn't have had the opportunity to make that change and a substantial portion of this council … wouldn't be sitting up here today."
Sittenfeld equated an election to a job evaluation. He, along with councilmembers Chris Smitherman and Charles Winburn, voted against the ordinance.
Quinlivan has said her rationale for pushing four-year terms would be to eliminate the cycle that currently has sitting council members spending half of their terms campaigning.
Councilman Cecil Thomas said four-year terms would allow council members to focus on longer-term projects as well.
"Four years gives us plenty of time to gel together, to work together," Thomas said.
Councilman Chris Seelbach attended all four public hearings council held throughout the city and called the number of people who support four-year terms "unbelievable." Seelbach said he himself was "semi-conflicted" over the proposed changes, but was not conflicted over whether voters should have that choice: He voted in favor.
Mayor Mark Mallory was sure to remind councilmembers before their vote that they are forbidden from using city resources to campaign for a ballot initiative.


text:
Truck Day: Spring Training is around the corner!
The overnight low in K.C. was two below, however, we are thinking spring! Staff from ballpark operations, the grounds crew and clubhouse operations braved the cold to load the spring training truck this morning. The truck is headed to Surprise, Arizona, where pitchers and catchers officially report in five days!


text:
WASHINGTON, DC (WUSA) -- Tracy O'Carroll says her daughter, Sarah, was reading a text message while driving. In an instant, the unthinkable happened.
"She died instantly. She swerved on the other side of the curve. The truck driver did everything he could to keep from hitting her," Tracy says.
Texting while driving is frighteningly common among younger drivers, according to a Consumer Reports National Research Center Survey.
Rik Paul says, "In our survey, nearly one in three drivers under 30 admitted that they'd recently been texting behind the wheel."
Consumer Reports checked out several new phone apps designed to limit texting and other distractions in the car. Some, like DriveSafe.LYPro reads text messages to you. It sends your message back as a text. That keeps your hands on the wheel and your eyes on the road. But, it isn't perfect.
"We found that it doesn't always recognize what you're saying the first time, and repeating your commands can be annoying," Paul says.
Another app called txtBlocker goes even further. Parents can install it on a teen's phone for $7 a month.
When the phone is in a moving car, txtBlocker blocks any incoming messages and disables the keypad.
"For a concerned parent, txtBlocker is the most effective system we've tried. But, for all drivers, the best and least expensive way to stay safe is to simply turn off your phone behind the wheel," Paul says.
It's a message Tracy O'Carrol hopes will save lives.
Before you buy an app or hands-free system, check the product's website to be sure all of the features are compatible with your smartphone.
If you have T-Mobile, the carrier has its own service that blocks texting while driving. It cost about $5 a month.
MORE: Guide To Distracted Driving And Teen Safety
The Department of Transportation just announced it will partner with Consumer Reports to fight distracted driving.
Click Distracted Driving Shatters Lives for free guide.


text:
Vote: New Entries for Monday 5.6.13
Small Cool Contest
Who has the smallest coolest home? It's up to you to decide. Click through to check out today's entries and then vote for your favorites.
- Tiny: Danl's New Life in a Studio
- Little: Hadley's Cozy Condo in Boston
- Small: Chris & Julia's Top Floor Abode
- International: Sharona's Artistic & Colorful Home
- International: Lee's Only Meaningful Possessions


text:
Just Add Water
|Release Date: March 28, 2008
|Running Time: 95 mins.
|MPAA Rating: R
|Genre: Comedy, Drama, Romantic Comedy
Danny DeVito
Dylan Walsh
Katey Sagal
Jonah Hill
All Cast & Crew >>
Summary:Ray Tuckby has stayed in the once idyllic, now decrepit and barren town of Trona in order to remain near the unrequited love of his youth. The town is run by a teenage drug and real estate kingpin, and when a stranger comes to Trona with dreams of turning the town around, Ray and his friends team up to defeat the young thugs and return Trona to its original splendor.


text:
Currently Shopping by
We offer assembly of most invitations that are layered or that have embellishments (for example the Versailles or Victoria Damask invitations). Assembly means that we will adhere each layer of the invitation together or tie any bows or ribbons. If you order a Pocket or Bloom, all of your layers will be mounted directly onto the Pocket or Bloom, unless otherwise specified. If you order an invitation with ribbon, your ribbon will be cut and attached to your invitation. Assembly does not include inserting your invitation and accessory cards directly into your envelopes.
We do not assemble any accessories such as seals, etc. If you are assembling yourself, we recommend a strong, thin double sided adhesive to attach the different layers of the invitations. Please DO NOT use any type of "wet" glue, since you don't want the cardstocks getting damp or wet which can lead to wrinkling and/or buckling, and in some cases we have found with rubber-cement glue, the actual letters falling off your invitation!
Wedding Planning Timeline
American Wedding Wisdom
Guide to Wedding Stationery
About Us
Contact Us
Customer Service
Shopping Basket
Privacy Policy
Shipping Info
Terms & Conditions
Download Order Form
Type Style Options
Ink Color Options
Design Options
Invitation Guide
Wedding Invitations Wording


text:
Providing Creative Solutions to Complex Legal and Business Problems
Nelson Mullins Riley & Scarborough LLP
Washington, District of Columbia 20001
(202) 712-2800 or(800) 237-2000
(202) 742-2860
Law Firm Overview
Nelson Mullins is committed to providing creative solutions to complex legal and business problems and to adding value to their clients. With more than 35 diversified practice areas and more than 350 attorneys, the firm has grown to meet the expanding needs of existing clients and to accommodate the concerns of new ones. Having nine offices in Georgia, North Carolina, South Carolina, and Washington, D.C. allows the firm to serve clients throughout the Southeast and maintain national presence.
Many of Nelson Mullins' clients, from individuals to worldwide organizations, look to the firm for full legal services. Start-up assistance for entrepreneurial endeavors, complex multi-action litigation defense, and representation of underwriters and investment bankers are only a few of the services that are provided by firm attorneys.
The firm is large enough to ensure promptness of service, yet personal enough to maintain their established reputation for individual client attention. Nelson Mullins is committed to providing the highest level of service to clients, while continuing to develop new areas of talent and knowledge.
Nelson Mullins Riley & Scarborough LLP - Providing services in the following areas of law:
- Administrative Law
- Alternative Dispute Resolution
- Antitrust and Trade Regulation
- Appellate Practice
- Aviation Law
- Banking and Finance
- Banking Law
- Bankruptcy
- Business and Industry
- Business Litigation
- Class Actions
- Commercial Litigation
- Constitutional Law
- Construction Accidents
- Construction Law
- Consumer Law
- Contracts
- Copyright
- Corporate Law
- Corporate Litigation
- Criminal Law
- Debtor and Creditor
- Employee Benefits
- Employment
- Energy
- Environmental and Natural Resources
- Environmental Law
- Estate and Trust
- Estate Planning
- Ethics
- Family Law
- Finance
- Financial Litigation
- Financial Services Law
- Franchising
- General Practice
- Government
- Government Contracts
- Green Cards
- Health Care
- Immigration
- Insurance
- Intellectual Property
- International Law
- Internet Law
- Investment Law
- Licensing Law
- Litigation
- Malpractice
- Mergers and Acquisitions
- Municipal and State Law
- Natural Resources
- Naturalization and Citizenship
- Outsourcing
- Patents
- Personal Injury
- Pharmaceutical Law
- Premises Liability
- Product Liability
- Professional Liability
- Professional Malpractice
- Public Finance
- Real Estate
- Science and Technology
- Securities
- Sports and Recreation
- Tax
- Telecommunications Law
- Toxic Torts
- Trademark
- Transportation
- Utilities
- Visa
- White Collar Crime
- Workers Compensation


text:
Fat Head J/24 Mainsail
1,2,3 2014 Worlds
DX-7TT Twaron/Technora J/24 Genoa
#1 2014 J/24 Worlds!
SD/TH J/24 Twaron/Technora Genoa
#1 2014 J/24 North Americans!
3rd at the 2014 Worlds!
Super Rocket Blade + J/24 Jib
1,2,3 2014 J/24 Worlds!
FR-2 J/24 Spinnaker
2,3 J/24 Worlds!
#1 2014 J/24 North Americans!
Spinnaker standard features:
Newport Slant Nose+ J/24 Spinnaker
With regards to the backstay we thought having it off to
measure the forestay would make it easier to get a method where all boats could
be tuned the same. You are right that just hooking it up and even trimming the
main effects how much the forestay will sag...
that in mind we suggest (this is in the tuning guide) that the tension on the
backstay bridle always be adjusted so the blocks sit about 8" below the triangle that joins everything together.. So
each time you tighten or loosen the shrouds for a change in wind velocity you
will need to do the same for the backstay bridle.
It is really important to sail at max weight 882 lbs. In anything
above 10 kts, that extra weight is noticeable in terms of upwind
performance. At the top of the fleet, we try really hard to make sure
we are max crew weight.
Changing gears in the J24 is huge! The skipper has a lot on
his plate. The top guys make the skipper responsible for the backstay,
traveler, mainsheet, Genoa trim and steering the boat. Let me try to
explain how this works. A nice steady breeze makes it a lot easier
obviously. In the steady breeze you can kind of get things set up and
just rumble. In a puffy breeze, there is a constant adjustment of the
Puff hits…crew eases genoa, skipper eases traveler.
Puff begins to ease up,skipper pulls traveler back up, cleats it. Then moves quickly to the winch handle and cranks in the genoa.
Repeat the above sequence with each new puff.
There are different variations of this depending on-strength of the puffs. If the puffs are very strong…vang sheeting-becomes a little more effective. A super tight vang and using the process above, but instead of easing traveler down, you're easing mainsheet.
The backstay should be set as close to a happy-medium as possible, but every now and then it should be adjusted based on the overall trend of the breeze. I like to have it eased in the light spots as much as possible, as long as you can get enough back on before the next big puff hits.
It would be nice to have three hands. Trust me it is not easy…it takes a lot of practice.
You want to start by getting your boom at centerline. You
accomplish this with mainsheet tension and traveler. The mainsheet
tension controls the amount of twist in the sail and leech tension. In
light air or light spots, you want twist (and the top leech tell tale
flying)…so softer mainsheet tension and a higher traveler to keep boom
at centerline. A twisty main is also good for accelerating or for bow
down modes. You want nice twist in your main after a tack to help the
boat get back up to speed quickly. In medium breeze, you want a tighter
mainsheet to close the leech a little for better pointing. You have to
ease traveler down to keep boom at centerline if you pull on mainsheet
tension. The only time you let the boom go below centerline and go
traveler down is when you really need to de-power and keep the boat flat.
Even before a lot of traveler down, I am usually putting on some
backstay to de-power.
The backstay has a few rules of thumb. Take some off for
more power and pull some on to de-power. If your main starts to invert
and flog, you should ease some backstay to get flow over the sails going
again. Backstay is more of a macro adjustment unless it is really
puffy, then you are constantly easing it off in the light spots. Also,
if you are ever overstood in breeze and need to crack off, put lots of
backstay on. If you need to point higher in a short distance like if
you understood the windward mark, take backstay off.
The Genoa trimming by the skipper is key. Basically the
skipper sits right next to the winch that has a winch handle in place.
In a puff the trimmer, who is hiking out all the way, will ease the
genoa in anticipation of the puff, not letting the boat heal over (we're
talking like a foot or more of ease at times), and then the skipper
winds the winch handle to crank the sail back in before the boat heals
to windward. This takes some practice, but once you get it, it's huge.
Never let the boat heal to leeward. Anytime the boat is healing it is
sliding sideways a lot faster than you think. When a 30 knot puff
hits, you actually have better VMG if your boat stops dead in the water
and remains flat, than if you heal over, go forward but slide sideways.
The boat that stopped dead in the water will actually be closer to the
windward mark after the exchange.
How often do we get new sails? The Genoa obviously takes the
biggest beating. After only a couple heavy air regattas you will be
able to notice a performance difference between a new and used sail.
It's not only the beating the sail takes against the mast in tacks, but
also the crew stuffing it up on the bow during downwind sailing. You
might not like to hear this but we make sure we have a new Genoa for
every big event.
Quantum is pushing a material called AirX. What is you opinion and what type of material is the North Spinnaker made out of.
We make our sail out of a material called Superkote. Both, the Superkote
and the AIRX 650 which Quantum uses weight very close to the minimum
allowed weight of 42 grams per square meter. I have used AIRX on a
number of
J/24 spinnakers. My conclusion is that it makes a good sail but one
that is best in flat water and a good breeze. The Superkote is actually a
little softer which makes the sail more forgiving in any of waves and
lighter winds. Superkote also seems to last a little longer as it relies
more on the weave of the cloth for strength rather than a surface
coating. / Answer by Chris Snow
I've been told J24s roll tack easy enough. Using techniques I adapted from dingy racing and a basic knowledge of hydrodynamics, I tested this theory and couldn't get it to roll over. Is there a better technique for fixed keels that i don't know about?
Roll facing out and push down on the windward
life line. Start from the middle of the boat and do it all together.
With four people rolling you should be able to get the windward rail all
the way down to the water, once it is flatten the boat slowly and you
will get a nice squirt forward.
What is your feeling about Newport vs San Diego cut. I sail in the Inland NW.
Sailing on a lake where the wind is shifty I would choose the San Diego designs. This sail is fuller in general especially in the middle which
makes it more forgiving to trim in variable and shifty conditions.
sail can take quite a curl before it becomes unstable. The Newport
better in open water straight line sailing.
What is your opinion about having multi color sails. I read somewhere that it was better to have one color due to the stretch in the panels over time. Is this a big issue?
We highly suggest having the head and clews of the sail each a
solid color. Also I would try to have these areas lighter colored if
possible. This way the top and bottom of the sail is made from the
lot of cloth and it will stretch relatively evenly over the life of
sail. Also making the sail with lighter cloth in the top and bottom
insure that you are getting a sail made with Grade A woven cloth. With
darker colors flaws can be hidden and even though all the cloth is
tested by the maker and us this generally seems a safer bet.
The tuning guides tell me about which ring to fly the pole from but as the wind builds I find that the floating tack sometimes wants to fly quite high. The question is once you have got the pole to horizontal, do you keep raising the pole to keep the kite level or do you use the barber hauler (twinning lines) to keep the floating tack down to the pole tack. Does water conditions affect your thinking on this?
Generally the J/24 likes the pole on the low side so while
we try to keep the clews level we also work on keeping the pole end
little lower than the free flying end. We generally twing the pole
down enough that the pole will sit right up at the tack of the spinnaker
at all times.
What's the difference between the San Diego and Newport sails?
The mainsails ARE very similar. I know the San Diego sails well and
have helped to develop these sails. About two years ago we made the
main significantly flatter. The reason was that the J/24 likes the main
trimmed really hard and for sure a flatter main can be trimmed harder
before it stalls. Both mains are quite forgiving.
The San Diego genoa is touch flatter than the Newport genoa (The Newport
main is flatter than the San Diego so needs a fuller genoa to go with
it). We have found that the sail is really fast in the upper end conditions
with the genoa where sailing the boat and keeping it flat is harder. In fact
the sail was so good in a big breeze that we just made the top of the
sail a little fuller to make it easier to keep the boat going in lighter
There is no real reason to have to change
the mast butt position once you find the proper location. Here we use
a Loos Model B tension gauge and with the lowers on 21 and the uppers
on 24 we measure the headstay tension with the backstay completely disconnected.
The headstay will be loose and the tip of the gauge should be about
30 mm from the headstay if you have everything set up right. You will
also have about 3 to 4 cm of prebend at this point. The only time I
have seen adjsuting the butt while racing work is when it is really
blowing hard (25 knots plus) and then moving it forward just a bit MIGHT
How to ease and trim the main and jib together smoothly? Well..easing isn't hard but since I grind the winch for the jib/genoa and pull in the main they don't come in together, it's always one or the other first. Both together is obviously better but I'm not sure how to do it. Do you have the cockpit guy grind in the jib himself and only worry about the main when both are eased or do I just try to do both myself. How do you do it?
You are talking about when you are cross
sheeting the genoa and jib. Basically I think the best thing to do is
if you just ease the jib a inch or two, you need to grind the sail back
in a keep the cockpit guy hiking out.
Yes the sail will not be trimmed in exactly
the same but I think this is less disruptive. If you have the ease the
jib a lot (like when ducking) have the cockpit guy turn around and grind
and tail the sheet him/herself. This way you can concentrate on the
The balance between the two sails on
a boat like a J with the a small keel is important. Keep playing the
sails in concert with one another.
How can I get my J24 to point higher?
Generally the reason a J/24 does not point (or sail as
close to the wind as the boats around it is because the boat is not
developing enough weather helm. The boat needs a small amount of weather
helm to be able to always sail as close to the wind as possible.
The first thing to do is to recheck your boat against
the tuning guide to make sure you have followed everything correctly.
If this is so then I like to go out sailing with the rig tuned properly
for the wind and take a close look at the mainsail set up. Usually what
you will find in these cases is that the lower part of the main to too
flat relative to the top of the sail. In general the sail should have
a nice smooth shape from top to bottom, often in cases where the boat
is not pointing well the bottom of the main will be very flat right
off of the mast indicating that we need to move the mast butt forward.
Start by moving it ¼" and see if that makes a difference,
it should make the lower part of the mast a lot straighter and give
you more helm and height!
My J/24 sails nice and high but I can't get it to go as fast as the other boats through the water. What can I do?
You basically have the opposite problem of the folks in
the question above. There are times in race where tactically you want
to " put the bow down" and just go fast regardless of height.
If your boat won't do this you are handicapped a bit. The problem is
that your lower mast is too straight which makes the main too full and
causes you too develop an excess amount of weather helm. Every time
you try to sail the boat low and fast the boat heels too much and develops
more weather helm. Move the mast butt back ¼" to put in
more lower bend, recheck your shroud tensions and you should be all
Should I use the upper or lower ring on the mast for the spinnaker pole?
With the Newport spinnaker we use the lower ring until
about 15 knots of wind. For the San Diego spinnaker use the lower ring
until about 10 knots.
When I sail in heavy air with the jib I can't get the jib halyard tight enough to remove all the wrinkles in the luff of the sail?
Above 20 knots you want the luff of the class jib smooth
with no wrinkles. To get the halyard tight enough sail downwind before
the start with the backstay off and have two crew pull up the halyard.
This should get it tight enough. Be sure to get the jib up BEFORE you
tighten the backstay at the leeward mark.
How important is the J/24 spreader angle adjustment? This seems to be hard to get right.
The spreader angle is hard to get right but it is worth
the effort. The spreader angle affects how "stiff" the mast
will be in the boat. Angle the spreaders forward and the mast gets stiffer,
sweep back and the mast gets more flexible. This is important because
as we tighten the backstay we need a certain amount of stiffness in
the mast so the headstay will get tighter and flatten the genoa as the
breeze builds.
Have a Question?Please contact the J24 Experts or your local North Loft or Agent for additional information and questions about our products.


text:
Rockers KISS have confirmed plans to play a residency in Las Vegas.
The group, led by Paul Stanley and Gene Simmons, will play a nine-show run at The Joint at Hard Rock Hotel & Casino in November.
Tickets for the shows, which begin on Nov. 5, will go on sale on Friday.
The Joint has previously hosted residencies by Motley Crue, Guns N' Roses and Def Leppard.
The new KISS residency begins the day after the end of KISS Kruise IV to the Bahamas.


text:
Images: 25th CAB loads helicopters on planes [Image 20 of 20]
Photo by Sgt. Daniel Schroeder
Soldiers from 209th Aviation Support Battalion, 25th Combat Aviation Brigade, tow a UH-60 Black Hawk medevac helicopter from Company C, 2nd Battalion, 211th Aviation Regiment of the Minnesota National Guard, towards a C-17 Globemaster III to be transported to Forward Operating Base Shindad, Afghanistan, on Kandahar Airfield, Sept. 24.
This work, 25th CAB loads helicopters on planes [Image 1 of 20], by SGT Daniel Schroeder, identified by DVIDS, is free of known copyright restrictions under U.S. copyright law.
Date Taken:09.24.2012
Date Posted:10.08.2012 04:54
Photo ID:677977
Size:3.47 MB
Location:KANDAHAR AIRFIELD, AF
Hometown:HONOLULU, HI, US
Hometown:TAMPA, FL, US
Hometown:WHEELER ARMY AIRFIELD, HI, US
Gallery Images
Associated News
25th CAB loads helicopters on planes


text:
"It's not the years...it's the mileage."
Though the novelty of The Expendables' all-star cast of '80s and '90s action heroes wore off somewhat by the time The Expendables 2 hit theaters, the resurgence of aging tough-guy actors continues with the success of Liam Neeson's Taken 2, which beat down the competition this past weekend. And there's more to come. Ah-nuld's getting back in the game with The Last Stand and Bruce Willis is dusting off John McClane for a fifth go-round in A Good Day to Die Hard. But, not all aging actors can continue to pull off the kind of tough-guy roles they played in their youth. Tell us which over-50 actors still have what it takes to beat up the bad guys and come back for more.
Rate the Top 10 Tough-Guy Actors Over 50 Still Making Movies >>


text:
Wall, Wizards Go 3-1 as Washington Slowly Returns to Respectability
With Wall back in the mix, the Washington Wizards have been mixing it up with even the NBA's best teams. After posting a 3-1 record this week, Washington hasn't been the pushover they've been in years past. Wall made his first start after coming off the bench as he recovered from his knee injury.
Now with a healthy Wall and Nene, the team's talent is evident as Washington runs into the second half of the season. The AFRO recaps a week that went well.
Jan. 21—Washington 98, Portland 95: This game was all about "the shot" or "The Dagger!!!" as Wizards announcer Steve Buckhantz eloquently put it, as Jordan Crawford's buzzer-beating three-pointer rained from the rafters into the bottom of the net at the always hostile Portland Rose Garden arena. Washington hung close throughout the game before Crawford's 30-footer swished in as the buzzer went off. "Dagger!!!" Buckhantz screamed following the feat. Nene led the Wizards with 24 points, nine rebounds, five assists and four steals, and tied Martell Webster with four three pointers each.
Jan. 23—Utah 92, Washington 88: Washington erased a 22-point deficit to pull within two points late in the fourth quarter against Utah. But on the last game of their five-game road trip, Washington just didn't have enough gas to finish. Utah led most of the night, but extended the lead to 22 points early in the third quarter. Six players from the Jazz scored in double figures while Webster led the team with 15 points. Wall came off the bench to score 14 points and record eight assists. Emeka Okafor hauled in 17 rebounds.
Jan. 25—Washington 114, Minnesota 101: The Wizards made a much-needed return home to the Verizon Center and blitzed the Timberwolves from the start, scoring 60 points in the first half for the first time this season. Six players scored in double figures for Washington, with Crawford leading the team with 19 points. Washington shot 8-of-17 from long range and Wall made his first start of the season, recording 14 points and five assists. Rookie guard Bradley Beal recorded 16 points and four blocks.
Jan. 26—Washington 86, Chicago 73: In a sold out Verizon Center, Washington stunned the 26-17 Bulls with a slugfest. Washington held Chicago to just 40 percent shooting from the field and 26 percent from three-point range. Wall was again efficient, recording 15 points and seven assists. Emeka Okafor hauled in 15 points and 16 rebounds. Chicago appeared a bit weary after playing the night before, but Washington didn't care and used a 50-31 run over the second and third quarters to put the game out of reach. It was an impressive display for the home fans at the Verizon Center, who gave a standing ovation as the clock ticked away to celebrate a healthy Wizards team.
With Wall and Nene healthy, Washington is rounding into form. Their starters are back and the depth on the team is apparent. With their starters out at the beginning of the season, a lot of players recorded significant time which has paid off. At 11-31, the season isn't over, and Washington is making a push in the standings.
530 total views, 1 views today


text:
Memorial Day in the Valley
Western Reserve vs. Cuyahoga Heights
Photos: Milton Twp. fire
Abandoned Geauga Lake Park
GM Lordstown open house
May arrests
Report It
Photos: Wheelchair Van Crashes
US & World
Navy pilots at hospital following crash
Disney ticket redeemed 22 years later
Timeline: EgyptAir Flight 804 crash
EgyptAir Flight 804 crash
8 shot dead at 4 locations in rural Ohio
Columbine High School massacre
Photos: Bernie Sanders visits Purdue
Bernie Sanders rally at UMass Amherst
New Hampshire: Behind-the-Scenes
The Road to Nomination
Taking Your Questions to the White House
Dem. 2016 Debate - Manchester, NH
8 Iconic TV moms from ABC hit shows
Remembering Prince (1958 - 2016)
SXSW Film 2016 : Part II
SXSW Film 2016
Rory and Joey Feek throughout the years
Oscars 2016: Winners
Photos: Easter Seals Fashion Show
McDonald's through the years
Photos: Lordstown Plant Renderings
10 Delish Drinks: Margaritas
Man hands out love notes to honor wife
Lafayette's The Grand Theater Reopening
Photos: Youngstown holiday parade
1960s Youngstown holiday parade
2015 Turkey Trot
Photos: Memorial Day celebrations
Barbecue Across the U.S.
Easter Sunday around the world
Snakes found in North Carolina
Baby animals on display in Greenville
Woman reportedly attacked by 3 dogs
Pets enjoy February flakes
Houston Zoo residents feel the love
Animals rescued from 2 Tennessee homes
2016 NFL Draft 1st Round Picks
AP Photos: 120th Boston Marathon
Photos: Kennedy Catholic Basketball
Photos: McDonald 67, Wellsville 48
South Range 62, United 53
Photos: Columbiana 50, South Range 32
May Weather Images
Photos: Winter Snowstorm April 9, 2016
April Weather Images
Rainbows after storms in Tennessee
March Weather Images
East Coast battered by storms, tornadoes
September 11
Last living Ground Zero rescue dog
9/11 Ceremonies across Valley
Wayne CC 9/11 tribute event
The White House reacts to 9/11
New photos from 9/11
Photos: Valley commemorates 9/11
Animal Welfare League
Trumbull County Animal Welfare League held an open house today to show off its new facility on Route 193 (Belmong Ave.) in Vienna.
1 of 11
Animal Welfare League open house
Trumbull County Animal Welfare League held an open house on June 6, 2014.
1 of 11
All content © Copyright 2000 – 2016 LIN Television Corporation. All Rights Reserved.


text:
THORLO Kids' Snow Moderate Cushion Over-Calf Socks
|Eligible for Free Shipping on Orders $39 or More! (see promotion details)
Product Details
From sledding to building snowmen, these THORLO® Snow moderate cushion, over-calf socks will keep kids comfortable during their wintery adventures. Cushioning at the shin, ball and heel provides superior warmth and protection, while THOR-WICK® moisture-wicking fabric keeps young ones' feet nice and dry.
Get your new THORLO® socks today from Sports Authority.
What makes this product "Green"?
It's made from recycled PETE, a repurposed plastic material primarily used in packaging materials and synthetic fibers.
- 82% THOR-WICK® polyester, 16% nylon, 2% spandex
- 1 pair of over-calf socks
- Moderate cushioning at the shin, ball and heel for warmth and protection
- THOR-WICK® moisture-wicking fabric keeps feet comfortably dry
- Made in USA


text:
Blog Categories
- BPA Free Bottles (3)
- Contaminated Water (1)
- Flouride in Water (2)
- Glass Bottles (1)
- Global Cooling (1)
- Global Warming (6)
- Monsanto (1)
- Nuclear Runoff Spilling (1)
- Water Filter Bottles (5)
- Water Purification Systems (78)
Recent Posts
- Britain now facing worst winter in SIXTY YEARS warn forecasters
- UN's massive new climate report adds little explanation for 'pause' in warming
- And now it's global Cooling! Return of Arctic ice cap as it grows by 29% in a year
- Top MIT scientist: Newest UN climate report is 'hilariously' flawed
- Climate Expert Warns of Impending Global Cooling Crisis
- EarthLust's Safe Bottles New Zealand
- World's temperature hasn't risen for the last 15 years
- 'Days of eating Pacific Ocean fish are over'
- Nuclear crisis: Japan desperate attempt to stop Fukushima leaks
- BPA Free Bottles, Stainless Steel New Zealand
Recent Comments
EnvironmentANSI Australia BENEFITS BIOSAFE Black Berkey BPA camping Canada Chemicals Dissolved Solids Drink Bottles ELEGANT emergencies EPA FEATURES Filter Bottle filtered water Filter Replacement HEALTHY HISTORY IPCC Klean Kanteen Klean Kanteen Classic Metallic Blue Metallic Red New Zealand NSF POWERFUL PROVEN purifier Read Full Article Red Cross Seychelle Stainless Steel Sport Berkey stainless steel stainless steel bottles Storage Capacity Tap Water UN United States US USA Water Water Filter Bottle Water Purifier
Tag Archives: BILLION
On average, bottle water costs 2000 times more than tap water. (The Story of Bottled Water) People in the U.S. buy more than half a BILLION bottles of water every week! Enough to circle the globe twice. (The Story of … Continue reading
Posted in Water Purification Systems Tagged Aquafina Pepsi Co, BILLION, Dasani Coca Cola, Fast Company, Klean Kanteen, Plastic Pollution, Surfrider Foundation, United States, Water Comments Off


text:
Deliver better service levels while reducing costs with SAP service parts planning and procurement software. Our software provides capabilities for parts demand forecasting, inventory planning, and distribution modeling. Designed to the demanding needs of your business, it supports planned inventory across a distribution network.
To meet customer expectations, companies must be able to coordinate and collaborate in real-time across all service parts processes, including planning, procurement, transportation, warehousing and fulfillment – globally, across the entire service supply network. See how SAP can help.
When Ford Motor Company decided to overhaul its service parts management systems, the auto giant teamed with SAP to develop a world-class service parts planning solution. Ford was able to enhance the quality of its customer service, while improving planning capabilities and supply chain visibility.
Learn how Cat Logistics has developed best-in-class demand planning processes for service parts management. The company is now able to proactively address customer demands and drive profitable growth.
Want to learn more about this SAP solution?
*All implementation results are for informational purposes only and the examples provided while based on actual SAP customers' experiences do not represent commitments or guarantees by SAP and/or its partners. Actual pricing, costs, and implementation results may vary, based on customer-specific requirements and needs. The only warranties for SAP products and services are those that are set forth in the express warranty statements accompanying such products and services, if any. Nothing herein should be construed as constituting an additional warranty.


text:
Need training at your business?
LBCC offers a wide array of services through its Business and Employer programs. See what we have to offer.
Kids and Families
Who doesn't need a little help? Check out Family Connections and Parenting Education.
Program spotlight
Parenting Education offers classes to support childrens' development, build parents' insights and skills, and allow everyone to make friends.


text:
Topic: Login Fail/ Server down
We have been using iRedmail-Pro LDAP for about one year. But today morning we are facing a great problem that log in fail. Sometimes IMAP error message occours when we are going to log in. When I am going to Log in to iRedadmin then it says "Server is down, Please contact webmaster to solve it". Can you please help me?
- Urgent issue? Pay iRedMail developer to solve it remotely at $39.


text:
Community Engagement
Expanding Your Worldview through Study Abroad
Summer Study Tour of Africa participants in front of the South Africa Parliament building. (Photo, courtesy of Elizabeth Morrisey)
Study abroad experiences can have profound effects on a student's global perspective. Such is the case for UAlbany senior Casie Addison who discovered, during her study abroad experience, the great inequities that persist in post-apartheid South Africa.
"I recall driving along a highway in South Africa from the airport. To my left were the formal houses or neighborhoods for the white Africans, and to my right were the townships and shanty houses where black Africans lived," said Addison, of College Point, N.Y. "It's still a vivid image, because I've never seen a poverty contrast like that in my life."
Addison, who is African-American, said the trip, which also included Ghana, gave her a deeper understanding of her ancestry and made her more familiar with African culture.
The Summer Study Tour of Africa is organized by the U.S.-Africa Partnership for Building Stronger Communities Project, which was founded 13 years ago by School of Social Welfare Distinguished Professor Shirley Jones. Led by Associate Professor Robert L. Miller, Jr., Ph.D., the tour is part of a three-credit course that exposes students to the policies that govern social service provision in Africa.
"When you see people who, by our Western standards, are living with what seems to be nothing and yet are still genuine good people, it makes you reconsider the things you value and our purpose in life," said Addison.
The group visited Robben Island, the prison that once held former President Nelson Mandela; toured The Vortrekker Museum and Freedom Park; experienced post-apartheid South Africa; and visited the Ghana AIDS Commission.
"Year after year, our students find that this study tour transforms their lives," said School of Social Welfare Dean Katharine Briar-Lawson. "Its high-impact effects are personally life changing and career enhancing. We remain indebted to the numerous donors who invest in our students to ensure that they have this deeply meaningful learning experience."
Among the group were second-year M.S.W. student Elizabeth Morrisey and UAlbany senior Hikaru Inuzuka.
Morrisey believed the experience helped her learn how social and economic problems are addressed in African countries. The Albion, N.Y., native wants to work to combat human trafficking, ideally for the State Department. Japanese native Inuzuka, studying political science and performance music, who also travelled to Africa with the group, felt it would serve as a great foundation for future work with an international organization like the United Nations.
As students move beyond this experience, they reflect on the profound impact it has on what they do today.
Jamie Dughi, an alum who earned her M.S.W. in May 2012 and is now a student at Albany Law School, said, "A year later, the life altering impact of traveling to South Africa with the illustrious Dr. Shirley Jones has only become more profound. A day has not passed that I do not think of the relationships formed, apply the many lessons learned, or reflect on the dedicated will of a country to stand in the face of oppression and change the course of history."
Dughi said she feels fortunate to have studied at the School of Social Welfare, where global learning and understanding are not just a classroom focus, but a tangible reality.
For more news, subscribe to UAlbany's RSS headline feeds
Educationally and culturally, the University at Albany-SUNY puts "The World Within Reach" for its 18,000 students. An internationally recognized research university with 58 undergraduate majors and 128 graduate degree programs, UAlbany is a leader among all New York State colleges and universities in such diverse fields as public policy, nanotechnology and criminal justice. With a curriculum enhanced by 300 study-abroad opportunities, UAlbany launches great careers. For more information about this globally ranked University, visit http://www.albany.edu/. For UAlbany's extensive roster of faculty experts, visit www.albany.edu/news/experts.shtml.