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Do you love trying to fix computer and network problems? Do you pride yourself on being able to find the solution everyone else is missing? If so, this is a great time to turn your natural talents into opportunities at the International Academy of Design & Technology. Our Bachelor of Science in Information Technology degree program can help you develop the knowledge and skills needed to implement, analyze and manage information systems.
According to the U.S. Department of Labor's Bureau of Labor Statistics, employment of network and computer systems administrators is projected to increase by 28 percent from 2010-2020 – faster than the average for all occupations*. Get ready to take advantage of the growing demand by learning industry-relevant skills such as programming, scripting, security and management. As a graduate of this Bachelor-level program, you could pursue a variety of career opportunities in the field of information technology and networking.
IADT's Information Technology Bachelor's degree program offers a dynamic curriculum that includes instruction in client and server environments, system security, Linux, and scalable directory services. By taking a variety of innovative classes, you can gain comprehensive training in computer and small-network installation and administration.
Below is a sampling of course topics included in IADT's Bachelor of Science in Information Technology degree program. Classes are taught by instructors who specialize in this field – many who are practicing professionals.
Course curriculum is subject to change.
International Academy of Design and Technology cannot guarantee employment or salary. Find disclosures on graduation rates, student financial obligations and more at www.iadt.edu/disclosures
For accreditation and licensure information for this and other IADT programs, please click here.
To request additional information about this program or how to apply for admission, please fill out the short form at the bottom of this page, and an admissions representative will contact you shortly.
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Program details may vary by campus. For more-specific information, please refer to the catalog for the campus that you plan to attend. IADT does not guarantee employment or salary. All trademarks are property of their respective owners. Bureau of Labor Statistics, U.S. Department of Labor, Occupational Outlook Handbook, 2010-11 Edition, Computer Network, Systems, and Database Administrator, on the Internet at http://www.bls.gov/oco/ocos305.htm (visited October 22, 2010). This is a national estimate and conditions in your location may be different.
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UPDATE: (7:35 p.m.) City council voted to keep the $7.50 monthly trash pickup rate for seniors and disabled citizens in Canton. Seniors will not face the proposed nearly 50% rate hike.
CANTON, Ga. -- For years, Canton seniors and the disabled have gotten a big break on what they pay for garbage collection.
Many Canton seniors shell out $7.50 a month while other households pay $16.50.
But even with twenty-one percent of Canton residents getting the discount, the city is still making a nearly $150,000 profit on garbage collection.
But, if a resolution passes at the Canton City Council meeting tonight, that $7.50 senior rate could jump almost 50 percent. It would grow to $11 a month.
Gene Hobgood, Canton's Mayor, doesn't like the idea of hiking the rate and does not want it approved.
"I'm not in favor of it certainly," he said.
"There are some (seniors and disabled homeowners) that really need that help out there. I think the cost of medicines, all of it going up, but incomes do not seem to change that much," Hobgood added.
"We are currently making thousands of dollars on our garbage services. It's not like we are looking to raise the rates on seniors just to make it break even. We are making money now," he said.
Despite the fact that the City of Canton is making a profit, seniors, many on fixed incomes, are up in arms.
"I don't think it should be put on the backs of seniors. We are all on fixed incomes and it is just not fair to us," said Russ Guinn, a Canton senior and homeowner.
"Everything is going up and now its garbage. It is just not right. We base our budget on what we have now and every time something goes up it makes it harder on us," he added.
Seniors are expected to show up at the Council meeting and make it clear they want the $7.50 to stay as it is.

subset: commoncrawl


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Our best Glasgow hotels
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After a day in the lively and exuberant city, relax in absolute opulence. Our award-winning luxury hotels in Glasgow boast lavish restaurants, beautiful locations and heavenly comforts. Unwind with a spa or golf weekend in stunning natural surroundings.
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MINNEAPOLIS – Hennepin County prosecutors announced charges against 20 men and women Friday afternoon in connection with what is being called a one of the most prolific methamphetamine rings in the Upper Midwest.
Local police and federal agents recovered nearly 17 pounds of meth with a street value of over $500,000.
Spokesman Chuck Laszewski says the charges are as a result of an eight month investigation called "Operation High Noon" by the FBI, St. Paul and Minneapolis police.
Authorities say Koua "Jimmy" Yang of Minneapolis and Jose Salgado of St. Paul, both 32 years old, were major distributors in the ring.
Laszewski says Yang and Salgado were supplied by Felix "Short" Lopez-Martinez, 23, of Cottage Grove, and 37-year-old Pedro "Peli" Ayala-Levya of Brooklyn Park.
In February, state troopers pulled over 33-year-old Daniel Samorano of Brooklyn Park. Samorano, who was driving back to Minnesota from California, had more than nine pounds of meth in a hidden compartment in his car.
An informant told the FBI that Lopez-Martinez and Ayala-Levya were associates of the La Familia Michoacana Mexican drug cartel.
Thirteen of the 20 charged are in custody. In addition to those already named, the following are in custody:
• Mario Alberto Castro, 28, Brooklyn Park
• Fong Meng Yang AKA Lucky, 27, Minneapolis
• Victor Alfonso Hernandez AKA Scarface, 25, Maplewood
• Kao Xiong AKA Milk, 27, Minneapolis
• Jerry Vang, 34, Brooklyn Center
• Jonathan Steven Schneider, 27, St. Cloud
• Xue Her AKA Al Bundy, 35, St. Paul
• Kong Meng Vang AKA Shot, 27, Minneapolis
The following were charged but remain at-large:
• Phong Yang AKA Fish, 27, Minneapolis
• Vinai Xiong, 33, Eau Claire, Wis.
• Paul David Vonrueden, 42, Anoka
• Foua Xiong, 26, Eden Prairie
• Elizabeth Catherine Gunderson AKA Mo, 37, Crystal
• Evalyn Lia Bheaanu, 30, St. Paul
• Jacqueline Joy Potts AKA Jeanie, 50, Cedar
Investigators say the drug ring was operating on a national scale. It was centered in the Twin Cities, but also included distribution hubs in Duluth, St. Cloud and Eau Claire, Wis.


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Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation.
Proc Natl Acad Sci U S A
Publication Year:
PubMed link:
Public Summary:
The role of alternative splicing in self-renewal, pluripotency and tissue lineage specification of human embryonic stem cells hESCs) is largely unknown. To better define these regulatory cues, we modified the H9 hESC line to allow selection of pluripotent hESCs by neomycin resistance and cardiac progenitors by puromycin resistance. Exon-level microarray expression data from undifferentiated hESCs and cardiac and neural precursors were used to identify splice isoforms with cardiac-restricted or common cardiac/neural differentiation expression patterns. Splice events for these groups corresponded to the pathways of cytoskeletal remodeling, RNA splicing, muscle specification, and cell cycle checkpoint control as well as genes with serine/threonine kinase and helicase activity. Using a new program named AltAnalyze (http://www.AltAnalyze.org), we identified novel changes in protein domain and microRNA binding site architecture that were predicted to affect protein function and expression. These included an enrichment of splice isoforms that oppose cell-cycle arrest in hESCs and that promote calcium signaling and cardiac development in cardiac precursors. By combining genomewide predictions of alternative splicing with new functional annotations, our data suggest potential mechanisms that may influence lineage commitment and hESC maintenance at the level of specific splice isoforms and microRNA regulation.
Scientific Abstract:
Two major goals of regenerative medicine are to reproducibly transform adult somatic cells into a pluripotent state and to control their differentiation into specific cell fates. Progress toward these goals would be greatly helped by obtaining a complete picture of the RNA isoforms produced by these cells due to alternative splicing (AS) and alternative promoter selection (APS). To investigate the roles of AS and APS, reciprocal exon-exon junctions were interrogated on a genome-wide scale in differentiating mouse embryonic stem (ES) cells with a prototype Affymetrix microarray. Using a recently released open-source software package named AltAnalyze, we identified 144 genes for 170 putative isoform variants, the majority (67%) of which were predicted to alter protein sequence and domain composition. Verified alternative exons were largely associated with pathways of Wnt signaling and cell-cycle control, and most were conserved between mouse and human. To examine the functional impact of AS, we characterized isoforms for two genes. As predicted by AltAnalyze, we found that alternative isoforms of the gene Serca2 were targeted by distinct microRNAs (miRNA-200b, miRNA-214), suggesting a critical role for AS in cardiac development. Analysis of the Wnt transcription factor Tcf3, using selective knockdown of an ES cell-enriched and characterized isoform, revealed several distinct targets for transcriptional repression (Stmn2, Ccnd2, Atf3, Klf4, Nodal, and Jun) as well as distinct differentiation outcomes in ES cells. The findings herein illustrate a critical role for AS in the specification of ES cells with differentiation, and highlight the utility of global functional analyses of AS.
PNAS Lens Free Article Link:


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key x_item TA6573
Triplex - Wayne Dobson
Item Number: TA6573
Three objects; a ball, a die, and a clear rod are shown. You ask the spectator to choose one of the three objects. You then reveal your prediction, which has been hidden behind a playing card and it matches the spectator's choice exactly.
All props are supplied with DVD with full instructions, hints and tips.
Customer Reviews Write a review.
No reviews yet. Do you own this product? Write a review.


text:
Style #:
Color:color size
Please Select a Color
Details/Features –+
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Does the Aqua Pulse record total work out time average and peak heart rates?
When it announces your heart rate it's simply taking the average of the last three readings. Meaning, if you had selected two-minute mode, it would simply tell you your heart rate over the last few seconds worth, rather than averaging it over the entire two minutes. It does not record data or track time.
I purchased the "original" Aqua Pulse and the bateery has expired. I asked Finis about battery replacement and they said there is none - the product is now worthless. The new model suggests a "free rechargeable Lithium battery". Does anyone know the life of the rechargeable battery? Can it be relaced in the device or it is permanently "fixed" within the device. Has anyone tested the new device? The original was fantastic while the battery lasted. Jim "O"
Never stop to check your heart rate again. With the AquaPulse® Heart Rate Monitor your current heart rate is verbally announced while you swim.
Simply slip the AquaPulse® inside your goggle strap, attach the soft rubber clip to your earlobe, and go swim. Using an infrared sensor to monitor capillary blood flow, your heart beat is detected through your earlobe. The heart rate is then audibly communicated to you in real time, where the information is transmitted directly to your inner ear via Bone Conduction Technology. No ear buds, cumbersome chest straps, or watch devices are needed.
The heart rate announcements are made regularly in 10-second, 20-second, 30-second, 45-second, 1-minute, 2-minute or 5-minute increments. Push the "Instant Heart Rate" button to hear your last recorded reading again. Complete with a lithium-ion rechargeable battery, you can use the AquaPulse® from five to eight hours depending on the interval setting. Simply plug the integrated USB directly into a USB port on your computer to recharge.
Audible Heart Rate in Real Time
Heart rate announced while you move; no need to pause and look at a watch
Bone Conduction Audio Announcement
Verbally conveys your heart rate through your jawbone into your inner ear; no ear buds needed
Infrared Sensor Technology
Picks up heart rate through your earlobe
Announcement Increments
Set the device to announce every 10 secs, 20secs, 30secs, 45secs, 1min, 2mins or 5mins
Instant Heart Rate Button
Repeats last recorded heart rate reading
Rechargeable Lithium-Ion Battery
Charges through USB port and provides 8* hours of use
*Depending on interval settings
USB Charging
To recharge, plug the AquaPulse™ directly into the USB port on a computer or USB wall charger
Made for swimmers by swimmers


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Want a free ringtone? Audiko.net! Just download a free Jamiroquai ringtones for your iPhone or mobile. Go for your favorite slice from your favorite thing - Deeper Underground, Cosmic Girl, Love Foolosophy, or any other track. Then download the prepared Jamiroquai ringtones to your mobile device, and enjoy Funk music by Jamiroquai every time your phone rings. If you prefer Funk or maybe Acid Jazz and Pop music, then you will probably like Moloko, Basement Jaxx, or Los Amigos Invisibles as well. For all who want a free Jamiroquai ringtone, we also recommend listening to Alternative, British, and Rock. Depending on a phone model, you can receive your ringtone both in the MP3 and m4a formats, compatible with both mobile phones and iPhones. Just select a track, and choose free Jamiroquai ringtones download option.
Download Jamiroquai Ringtones
6 Jun 2005
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I'm amazed at how quiet and smooth this engine is! Vibration is amazingly light, it's very responsive and powerful. It shifts as slick as a Honda, Handling is superb, this is a very flickable bike! No problems or niggles at all with it, In my personal experience with bikes, this is the finest 500cc single I've ever thrown a leg over, and I've ridden several variety's of them. RE got it right with this one. I removed the rubber blocks from the fins and couldn't hear anything different, so out they stay and it looks much better. My riding Buddy's have nicknamed it the "Ol' Poop" surely some of you will remember the ol poop from cycletoons magazine back in the day. If you do remember you'll know why the name will stick with it. The UCE Rocks!
Page created in 0.071 seconds with 36 queries.


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Adobe Research's achievements are the direct result of the bright talent and great dedication of our people. Here is an introduction to some of them.
Adobe Research is sponsoring the Berkeley AMP Lab this year.
Adobe Research had 10 papers accepted to SIGGRAPH 2014.
NSF 2014 Workshop, June 4-5, 2014.
CVPR 2014, June 24-27, 2014.
EGSR 2014, June 25-27, 2014.
SIGGRAPH 2014, August 10-14, 2014.
ECCV 2014, September 6-12, 2014.
UIST 2014, October 5, 2014.
ACCV 2014, November 1-5, 2014.
IEEE VIS 2014, November 14, 2014.
Check out our Distinguished Lecture Series >
Adobe Research is currently offering internships and hiring for full-time positions. We are looking for PhD researchers who are excited about pushing the state of the art in audio, graphics, vision, human-computer interaction, machine learning, visualization, analytics, optimization and more. We are currently recruiting, and we would love to hear from you!
Learn more about internships >
Our researchers collaborate with top faculty and PhD students from universities around the world. By proactively engaging with thought leaders, Adobe contributes to and benefits from advances in the broader research community.


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az eq6 can talk with eqmod
Posted 13 December 2012 - 06:38 PM
orange245 (on this board) tested if eqmod could run the mount via the (included) serial cable that goes to hand control and indeed it does.
Also wireless gamepad worked as a charm.
You first have to set handcontrol to "pc direct" mode of course.
I thought this might be of interest.
Posted 13 December 2012 - 06:40 PM
Posted 13 December 2012 - 07:56 PM
I really have to check out this EQMOD thing. I received my SkyWatcher AZ-EQ6, and I have been testing it with the SkyFi unit I had on my other multi-mount at DSRSG and my iPhone/iPAD. It may be hard to give up using the SkyFi.
Posted 13 December 2012 - 11:34 PM
Great news! Did you need any special adapter or did you use the serial cable that connects to the hand controller? (The one that came with the mount) also what did you pick under ascom...eq6? Thanks
Posted 13 December 2012 - 11:46 PM
Posted 14 December 2012 - 10:54 PM
Posted 15 December 2012 - 12:15 AM
Posted 15 December 2012 - 12:17 AM
Posted 15 December 2012 - 04:22 PM
I had no issues with the USB to serial converter. Just go to control panel, system, devices and choose com ports. This will tell you what port the adapter is using. Choose pc direct mode on the hand controller before starting Eqmod, and choose the port the adapter is using and your set to go.
I don't have a "com Ports" option in "system devices". I am using Windows 7. I had to change the com port setting in the EQMOD setup until I found the right one!
Posted 22 December 2012 - 10:05 AM
For example your com port that you want to use have number 23 and just dubble click on that port and then to the tab portsettings, and click on advanced. Change the portnumber to that one that you want to use, if it is a conflict with any other port just leave your usb cable connected to the computer and then restart. That should solve the problem if you have any in the future.


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This topic is archived and can not be replied to any more.
|AS To Get Rid Of Free Meals On Mid-Cons posted Mon Jul 17 2006 06:10:12 by RwSEA
|NW To Get Rid Of Ten A319s? posted Tue Jun 27 2006 17:13:54 by Flying Belgian
|DL To Get Rid Of It's 767-200s And 737-200s? posted Sun Nov 7 2004 18:57:31 by CLT18R
|Biman Wants To Get Rid Of F-28 - Month Old posted Sun Jul 25 2004 18:32:09 by GF-A330
|Gulf Air Future Plans - To Get Rid Of Widebodies posted Sun Mar 24 2002 18:04:12 by GF-A330
|United Planning To Get Rid Of Their 747s? posted Sat Dec 15 2001 02:52:22 by 2cn
|Gulf Air To Get Rid Of A340s And A320s posted Sat Dec 1 2001 01:43:34 by GF-A330
|Brittania To Get Rid Of 'Warrior Queen' posted Wed Aug 29 2001 19:17:33 by Jaspike
|How To Get Rid Of Scope Clouses? posted Thu May 24 2001 15:28:11 by KUGN
|American To Get Rid Of MD-80s? posted Sun Sep 17 2000 23:24:11 by ILUV767


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PHOTOS: Florida's rejected license plates aren't always offensive
St. Petersburg, Florida - Shot or mutilated, dead dolphins are turning up along the Texas border and throughout the Florida panhandle. National Oceanic and Atmospheric Administration officials are looking for the person or people responsible, and have also issued a warning for the Florida Gulf Coast.
NOAA officials say no cases of dolphin abuse have turned up along the Tampa Bay coastline or further south, but they are asking for the public's help to report any sightings because each case could hold a clue to solving these cases.
Dovev Weaver of St. Petersburg says when he thinks of a dolphin, he thinks of the friendly 60's show Flipper. Alyssa Weaver says they are not threatening animals. She says, "They're playful creatures who are always nice. They don't try to harm us, why should we try to harm them?"
Yet someone is harming them. Five dolphins have been shot in the last two years. Others are mutilated; one dolphin found near Gulfport had a missing jaw. Another found in Alabama had a missing tail.
In June, a boater took a picture off the Alabama coast of a dolphin with a screwdriver lodged in its back. It was found dead on a Florida beach the next day.
"It's very sad to think someone can do that to any animal... not just dolphins. But that someone could be cruel to animals is always heart breaking," says Erin Fougeres, a Marine Mammal Biologist with NOAA.
She says scientists are not sure if all the man-made injuries caused the dolphins' deaths, but can see how man may be responsible.
Fougeres says, "As animals being fed by the public, they learn to associate people with food so they may come and feed from fishing lines, and that upsets fisherman potentially."
Fougeres says these cases are part of a bigger problem facing the dolphin population in the Gulf coast. She says, "We have seen an unusual mortality rate since February 2010."
More than 700 dolphins have died and biologists with NOAA are trying to determine the cause. Fougeres says, "We are definitely concerned. If these cases occur more frequently, we want to be able to follow up and investigate all of them."
As for these obvious cases of abuse, the hunt is on. Weaver says he's hopes justice is served. "I hope they find the people who've done this. It's definitely uncalled for."
Dolphins are protected under the Marine Mammal Protection Act. The law says any harassment, hunting, capturing killing or feeding of the animals carries up to a $100,000 penalty and up to a year in jail per violation.
NOAA asks anyone who sees a dolphin stranding or case of dolphin abuse to report it to NOAA's Enforcement Hotline at 1-800-853-1964.
Isabel Mascarenas


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A best friend to talk
to, a pillow to sleep on, a blankie to snuggle with...
Your little one will
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mesh laundry bag for ease of care.
Age: 0+
Thanks Mama offers a wide variety of baby toys, cloth diapers, and baby carriers.


text:
Welcome to the Archived, Readonly Zimbra Collaboration forums. Heres the place where we talked about all things related to Zimbra email products. Registrations and postings are disabled here.
Be sure to visit https://www.zimbra.com/forums to start new discussions and to find the latest answers to questions being asked.
How can I use certificates in Zimbra Desktop to encrypt and sign my Emails?
View Tag Cloud
Forum Rules


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After a comfortable night's sleep guests can enjoy a high quality breakfastin the dining room.
The breakfast consists of fresh fruit juice, cereals, toast, .and plenty of tea or coffee. This is then followed by a fully cooked English breakfast comprising sausage, bacon, egg, mushrooms tomatoes baked beans. We serve breakfast between 8.30am and 10.00am.
Children have the same menu with an addition of pancakes.
2 sittings are provided at breakfast ensuring you never have to share a table with strangers or wait for a freshly cooked breakfast.
Evening meal available on request at a cost of £12.00 per person.
Our very own unique 'CYBER SPACE' is a computer room with 5 comfortable stations all having brand new Computer equipment, furniture and fittings. giving you the very best in house technology. Each station has Internet Access which means availability in abundance to the world wide web.
With our 'CYBER SPACE' there is no need to lug around your laptop trying to find a wireless connection. We provide the facility for you
Open Daily for either hot or cold drinks.
You can relax with a drink from our wide selection of beers, wines, spirits and hot drinks. The bar overlooks the children's room so you can sit in peace yet see where they are at all times.
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Situated on the sunny side of St Chads RD Far enough away from the noisy town centre yet within walking distance. Regular buses and trams within a 1 minute walk.
it is only a 5 minute walk to the pleasure beach and a ten minute walk to the town centre with plenty of shops on the way. 1 minute from the sea front
Address: Jesmond Dene Hotel, 20 St Chad's Rd Blackpool, Lancashire FY1 6BP, UK
Phone: 01253 346723
Mobile: 07867 486089
International: +44 1253 346723
Email: firstname.lastname@example.com


text:
Minneapolis, MN (Sports Network) - Rodney Williams Jr. put home 19 points on
8-of-14 shooting to go with six rebounds as No. 13 Minnesota polished off
North Dakota State, 70-57, on Tuesday at Williams Arena.
Trevor Mbakwe hit 5-of-6 from the floor for 14 points and pulled down 18
rebounds, while Andre Hollins buried 3-of-6 from beyond the arc for 11 points
for Minnesota (11-1), which has won seven straight since a loss to Duke on
Nov. 22.
Lawrence Alexander matched Williams' effort with 19 points of his own and six
assists, while Taylor Braun added 15 points on 6-of-12 shooting for North
Dakota State (8-3), which had a three-game winning streak snapped.
Marshall Bjorklund contributed 12 points and six boards in the setback.
The Sports Network


text:
Plus Blog
February 3, 2009
Tuesday, February 03, 2009
What would you like to know about your Universe?
This poll is now closed. The most popular question was "What happened before the Big Bang?". We will publish an article and a podcast with an answer in the middle of March. At the same time we will launch our next Universe poll, so watch this space.
Do you ever look at the night sky and wonder where it all comes from, where it is going and what we are doing right in the middle of it? Do you wonder if there's life out there, or why the sky isn't bright with all the stars that are in it?
If yes, then now's your chance to put your questions to world-leading astronomers and cosmologists, including Astronomer Royal Martin Rees and author and cosmologist John D Barrow. From now until the end of the year Plus will hold regular online polls to find out what your most burning questions are, and do our best to find an answer with the help of experts in the field. You'll be able to read and hear what they have to say in Plus articles and podcasts, and there'll be plenty of room for discussion on our blog.
Our first online poll — one of a total of seven — opens today. It will remain open for a month and we'll publish the answer to the question that proves most popular in the middle of March. This is your chance to get involved with the most fascinating science of them all (except for maths of course), and it's our contribution to the International Year of Astronomy 2009. So get voting now, and if your question isn't on the list above, send it to us in a comment on this blog, and we'll include it in the next poll. Happy voting!
Labels: IYA2009
posted by Plus @ 3:47 PM
23 Comments:
February 3, 2009
Tuesday, February 03, 2009
What can we learn from the British successes at the 2008 Olympics? Over the last few years in the lead-up to the London 2012 Games, there has been a massive influx of money and enthusiasm in the UK into Olympic sports and infrastructure. Other countries have shown similar improvement ahead of hosting the game. So is Britain's triumph an early result of the home advantage? And how will Britain perform in 2012?
Labels: sports
posted by Plus @ 2:38 PM
0 Comments:
January 29, 2009
Thursday, January 29, 2009
You've got two more months to join our maths writing competition, the Plus new writers award 2009.
We are looking for the science writers of the future, who can make mathematical subjects lively and interesting for a general audience. Whatever your age or background, if you've got a favourite bit of maths you think the world should know about, then we want to read about it. If you're a teacher or lecturer, then pass this link on to your students — there are special categories for secondary school students and university students.
Winning entries will be read by an international audience of over a hundred thousand in the June 2009 issue of Plus, and the winners will receive an iPod, subscriptions to the journal Nature, and signed copies of popular maths books by some of the best science writers today.
The closing date is March 31st 2009.
If you think you can share your passion for maths with the general public, visit the competition page and get writing!!
The competition is kindly supported by the Maths, Stats and Operational Research Network, a Subject Centre of the Higher Education Academy.
January 27, 2009
Tuesday, January 27, 2009
2009 is the year of astronomy and Plus will be part of the celebrations!
In May 1609 Galileo Galilei received reports of "a spyglass by means of which visible objects, though very distant from the eye of the observer, were distinctly seen as if nearby." Intrigued, he set about building his own version of this curious device, and he succeeded: by the end of the year he had discovered mountains on the Moon, the moons of Jupiter and the make-up of the Milky Way. His observations revolutionised our understanding of the Universe, and his use of the telescope marked the birth of modern astronomy — which celebrates its 400th anniversary this year.
posted by Plus @ 10:33 AM
1 Comments:
January 23, 2009
Friday, January 23, 2009
Darwin and the web of life
One hundred and fifty years after the publication of On the origin of species, it seems that one of Darwin's most fruitful ideas, that the course of evolution can be represented in the shape of a tree, is in need of updating. Evidence is mounting that what we should be thinking of instead is a web.
Reconstructing relationships between species from genetic information is a mathematical exercise, as well as a biological one. Darwin's tree of life, as a mathematical object, is an example of a graph, a collection of nodes connected by edges, with the special property that there's only one route between any two nodes. There are no circuits in the graph because it was assumed that genes can only be transferred between parents and offspring. But as Plus reported last year, there is evidence that genes can also be transferred between species horizontally, for example through hybridisation or swapping of genetic material between unrelated species. An article in this week's New Scientists brings together many strands of evidence for horizontal gene transfer. According to the article, the evidence doesn't just concern strange unicellular beasts, but also humans and other mammals: it is estimated that "40 to 50 per cent of the human genome consists of DNA imported horizontally by viruses"!
As a result, many scientists now think that a more general form of graph, a network, is what is needed to describe life. Given the potential complexity of networks, genetics may soon be in desperate need of mathematicians.
posted by Plus @ 4:35 PM
1 Comments:
January 23, 2009
Friday, January 23, 2009
Shine a light on dodgy stats
This week both the Daily Telegraph and the Daily Mail ran stories claiming that switching off street lights could significantly increase the number of road deaths. The stories were based on a paper published in the Cochrane Library, which considered three studies into the connection between road accidents and street lighting. However, it seems that the headlines are a typical example of misinterpretation of statistics.
As David Spiegelhalter, Professor for the Public Understanding of Risk at the University of Cambridge, writes on his website Understanding Uncertainty, the studies suffer from three major flaws: poor data, publication bias, and what's known as regression to the mean. Spiegelhalter points out that the three studies underlying the paper were poor and conducted decades ago, with one dating from as far back as 1948 — not a very good basis for drawing conclusions about today's traffic. The term publication bias refers to the fact that studies which show dramatic results are more likely to be published than those that don't. It's quite possible that there were other studies, which found no connection between street lights and accidents, but that no-one bothered to publish such boring results. Regression to the mean is a commonly observed effect, which results from random fluctuations. If street lights were installed on a certain road, then this is most likely because that road recently experienced a spade of accidents. Such a freak period can be purely down to chance, in which case one would expect the accident rate to return to normal after a while. Thus the improved accident rate after the installation of lights may be purely down to chance, rather than the improved lighting.
All this doesn't of course mean that street lights are useless. It simply means that the evidence is nowhere near as sound as the newspaper headlines claim. The Daily Mail, to its credit, did consult an expert, namely Spiegelhalter, but it's probably the headline, rather than his warning, that will stick in readers' minds.
If you're interested in matters of uncertainty and risk, then visit the Understanding Uncertainty website, or read Spiegelhalter's column in Plus.
Labels: Health and medicine
posted by Plus @ 3:15 PM
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I thought that some teams had a great weekend, and other teams not so much. Which teams do u guys think had the best draft?
Cyclone for life!
already a thread on this
"These are my new shoes. They're good shoes. They won't make you rich like me, they won't make you rebound like me, they definitely won't make you handsome like me. They'll only make you have shoes like me. That's it." - Charles Barkley
Originally Posted by Cardinal&Gold11
already a thread on this
ya look how many posts he has
Originally Posted by CycloneErik
And I'm thinking that cycofan just made the air, baby!
Originally Posted by rworkman83
I'll be honest, Cycofan1 sounds much older than what he makes me believe on here.
and the bears
Originally Posted by gocy444
and the bears
Da Bears
Originally Posted by Cycofan1
Da Bears
ha ya i had to go with my favorite team even though they didnt even have a 1st round pick
da bulls?
"I have come back to life!"- Ca-Mun-Rah/ THE DURANTULA"
Da Dolphins
Originally Posted by Cardinal&Gold11
already a thread on this
I love the people who always point out this is allready a thread.......get over it who cares
Originally Posted by CYCRAZY
I love the people who always point out this is allready a thread.......get over it who cares
i think theres a thread about this...........
There are not many crowds or places in the country that have a better impact on the game than at Iowa State. The Cyclone fans are truly a sixth man. The place is so loud and always a fantastic crowd." - Former Kansas and current North Carolina head coach Roy Williams
Originally Posted by whirlybirds
i think theres a thread about this...........
I did not know this....can you tell me more.
Depends on what you say is the best. I think that the Jets only having 3 picks did well. I think that the Bills did ok. The Bengles and Browns also did well I think. Then you had Philly and New England who did ok and the aquired a number of 2010 picks .
Iowa State
L.A. Rams
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I want to create an application platform based on PostGIS data. I read the documentation where I saw the prerequisite to install GEOS, GDAL and Proj4. The main problem is I am using windows platform. Can anybody refer me where I can get a full documentation on it to install PostGIS, GDAL, GEOS, Proj4 on windows with all their library? or is it possible to install all the library on windows?
You don't have to worry about any of those prerequisites when installing PostGIS on Windows. You just need to install the Postgresql installer for your platform. You can then launch the Application Stack Builder to install PostGIS.
You can find more detailed installation instructions at the Boston GIS web site.
I think R.K. answer is all you need, but if helps, I wrote a blog posts about installing and configuring PostGIS Raster on Windows
you can check out Portable GIS V3 which is newly released. the package contains what you need about GIS.
i hope it helps you...


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November 14, 2014 4:59 pm
Download audio
Neal Augenstein, wtop.com
LEESBURG, Va. – A determined Loudoun County girl, recently diagnosed with an inoperable tumor on her brain stem, is leading an effort to help other children facing life-threatening illnesses.
Three weeks ago, Gabriella Miller, a fourth-grader at Loudoun County Day School who is "almost 10," had been complaining of headaches and blurry vision.
"It was what no parent wants to hear," says father Mark Miller, sitting with his daughter in his lap in the family's living room. "It's a brain tumor."
"It became a whole new life. That was the day our life started differently," says Miller.
Gabriella is undergoing arduous radiation and chemotherapy at Children's National Medical Center.
"My head's going to be hurting because I've been tired all day," says Gabriella.
When I observed that grueling physical stress didn't seem very fun for a girl who loves dancing and "watching Disney Channel," Gabriella responded with an understated "eh."
The Millers say a social worker at Children's told them Gabriella qualified for the Make-A-Wish Foundation.
Gabriella chose a trip to Paris, and hopes to go after her chemo and radiation ends in January.
"I do want to go see the Eiffel Tower. I want to see the Mona Lisa."
And then Gabriella's focus partially shifted from her recovery efforts to helping other children.
Soon after Thanksgiving, Gabriella's mother Ellyn saw a full-page Macy's store ad.
Holding up the issue of The Washington Post, Ellyn displayed Macy's promise the company would donate $1 million to the Make-A-Wish Foundation if the company received one million letters to Santa Claus before Christmas.
Gabriella set a goal of contributing 10,000 letters.
Her selfless act quickly drew online attention and local support.
American Idol winner Taylor Hicks blogged and tweeted about Gabriella, asking his fans to participate in her effort.
The family along with family friend and marketing professional Christina Croll, set up a Facebook page entitled "Make A Wish with Gabriella."
Emails from strangers around the world are asking what they can do to help.
"I'm really happy about that," says Gabriella. "It's a blessing."
And Loudoun County Day School will host a letter-writing event Saturday morning from 10 a.m. to noon at 20600 Red Cedar Dr., in Leesburg.
A Smashing Time Mark Miller recalls searching for a way to provide a positive outlook for his daughter.
The answer came in the size and shape of a walnut.
"That's about the size of my tumor," says Gabriella.
Father and daughter searched several stores, looking for a package of walnuts in the shell.
"It was just before we started radiation," says Miller. "We went outside on the deck, and said 'we're going to smash these,' to give her a mental boost and to visualize what radiation would do to her tumor."
"This is our life, and we are not spectators," adds Ellyn Miller, who insists Gabriella and her younger brother Jake join the daily "smashing walnuts" routine – with pots, pans, mallets, fists, even shoes – to remind the children they are not powerless.
As she weathers treatment, testing, and probing from her "nine different -ologists," Gabriella gets strength from the promise of her trip to Paris.
"You might have a bad day today but there's always a bright star to look forward to tomorrow," Gabriella says.
Her parents are thankful for the hope Make-A-Wish Foundation is offering their daughter.
"If we can help raise some money so other kids can have that same feeling, I think that's absolutely amazing," says Ellyn Miller.
"It's not about Christmas, it's about what can we do to help kids who don't feel so good to feel better."
Follow @AugensteinWTOP and @WTOP on Twitter.
(Copyright 2012 by WTOP. All Rights Reserved.)
Memorial Day weekend events from around the nation, and the D.C. area, captured in photos.


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If you have not read the Liability Disclaimer for Students Housed in Privately Owned Facilities, please click here.
To browse through other pages of the off-campus housing list, click below for the first letter of the landlord's last name. If you prefer a hard copy of this list, you can select a page and click on the PRINT button of your web browser.


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Recipe submitted by: Geissler Baker, M.Ed.
Angel Hair Pasta with Garden Vegetables
Cook pasta according to package directions. Meanwhile, in large nonstick skillet, sauté the mushrooms, carrots, snow peas, yellow pepper, basil and garlic in oil for 2-3 minutes or until crisp-tender.
In a small bowl, combine the cornstarch, broth and salt until smooth; gradually stir into the vegetable mixture. Bring to a boil. Cook and stir for 1-2 minutes or until vegetables are crisp-tender and sauce is thickened.
Remove from the heat; stir in tomatoes. Drain pasta; divide among four plates. Top with vegetable mixture; sprinkle with cheese. Makes 4 servings.
Per Serving: 333 calories, 11g fat
For more information contact:
Geissler Baker, M.Ed.
Extension Agent, Family & Consumer Sciences
3309 Burlington Rd., Greensboro, NC 27405
Phone: 336-375-5876
Email: email@example.com


text: So, I decided to re-draw it and make it into something I would like. I have been working on it, off and on, for some time and right now I am about 95% done. I made it larger, with (what I think is) a more period feel and a much lighter hand on the colours. I also replaced the generic numbering system on the original map with province and territory names off of another game map I have (called Age of Napoleon). I missed filling in the name for Finland, and I need to change some of the flags, which I have been told are not quite right for the time period. Oh, and I also need to double check the spellings on the provinces. I know for a fact some of them have accents I will have to put in. Once I do that I will see about printing it out.


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Willow Nesting Tables, Set of 2
- Overview
Our nesting tables are ideal for entertaining because they offer quickly expandable serving space. Mirrored tops and curving bases make a striking backdrop for display. Place prized possessions on top to highlight their detail from every angle.
- Small: 19" w x 11" d x 19.5" h
- Large: 24" w x 15" d x 24.5" h
- Forged iron frame and antiqued-mirror tops.
- Hand-applied multistep matte finish in Dark Bronze.
- Assembly required.
- View our Furniture Brochure.
- Dimensions & Care
- Frames are constructed of welded iron.
- Finish is applied in layers, gently distressed and then finished with a moisture-resistant topcoat.
- Adjustable levelers add stability on uneven floors.
Small Table
- Overall: 19" w x 11" d x 19.5" h
- Top: 18.5" w x 10.5" d x 0.5" thick
- Clearance Under Table: 18.5"
- Distance Between Legs: 14.5" side to side; 8.5" front to back
- Weight: 18 lb
Large Table
- Overall: 24" w x 15" d x 24.5" h
- Top: 23.5" w x 14.5" d x 0.5" thick
- Clearance Under Table: 23.5"
- Distance Between Legs: 20" side to side; 12.5" front to back
- Weight: 25 lb
- Shipping & Return Info
View our Shipping Information
Return Policy
At Pottery Barn, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction is our priority. We carefully inspect your order prior to shipment. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement. If, within 7 days for Quick Ship upholstery and 30 days for all other products, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. Mattresses are final sale and may not be returned or exchanged.
We cannot accept returns on monogrammed, personalized, made to order items, or on items damaged through normal wear and tear. We also cannot accept returns of final-sale items which are identified by a price which ends in .99.
For returns of items purchased from your Pottery Barn registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later.
You may return merchandise through the mail for a refund or replacement. For detailed procedures for returning items through the mail, please contact Customer Service at 1.888.779.5176, 7 days a week, 5:00am - 9:00pm (PT).


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To @DrewMTips And @FrankLuntz: #Appeasement Is Not A Creditable #ForeignPolicy Strategy
I thought one of the more brutal lessons learn about WWII was that Appeasement doesn't work with authoritarians, but here they are beating that drum. I guess I was wrong. Up until last night, Frank Luntz has been posting pro-Russian propaganda tweets like this: Vladimir Putin says Russia has "the right to protect Russian-speaking populations" in other countries. http://t.co/fKboTs86FD #Ukraine — Frank Luntz (@FrankLuntz) March 3, | Read More »


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Hello All,
I have a few queries regarding ZPUSH2 and ZIMBRA-8-Opensource Edition
1> Is it possible to setup Z Push2 Properly with Zimbra 8 OE
2> Does outlook 2003,2007,2010 & 2013 Sync Directly without any hacks / tricks
(asking because i have many novice users in my organization)
3> Do all Currently popular Mobile Devices (Android / Win.phn / iOS) sync completely ? or do they need extra apps to sync?
3.1> if they do ! is it possible to sync multiple accounts with them ?
4> if i use Z Push2; will multiple / different Zimbra accounts(diff. domains) be able to sync calendar, tasks, contacts and mail ?
I am really sorry as i think this is the wrong place form these questions but i don't know where exactly to ask them !


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Hi all,
For about a year I am following Zimbra and it is getting better and better. I also looked at competitors but I feel that Zimbra is offering more especially the zimlets and editing documents online.
That being said, I looked at the prices and was wondering, how is it possible that you "only" have to pay around 3 dollars a user per month for such a product? I mean, salesforce can easily charge over 100 dollars per user per month and although directly used to grow your business, anyone should admit that, using Zimbra the way it is supposed to be, can return enormous efficiency gains.
So the questions:
1. Am I correct that you pay a max of 3 dollars/month for the most loaded edition?
2. When I have the above edition I "only" need a server to host the program?
3. For that price I can contact Zimbra in case of malfunction -support-?
4. If the above is true, why then is it so cheap? Do companies fail to understand the benefits of using Zimbra or any other collaboration tool? If so what arguments are they using?
5. Have I mist something?


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Last year, Snoop Dogg shocked listeners when he announced his joining the Rastafari movement and changed his name to Snoop Lion. Now, in a recent report from TMZ, it appears that members of the community are outraged by his highly-publicized religious conversion.
Bunny Wailer, Rasta practitioner and original member of Bob Marley & the Wailers, recently criticized the rapper. After viewing the documentary Reincarnated, which documents Snoop's conversion, Wailer said that Snoop was abusing the tenants of his religion for commercial gain.
"[His conversion is] outright fraudulent use of [the] Rastafari Community's personalities and symbolism. [Snoop has failed to meet the] contractual, moral and verbal commitments [of the Rastafarian religion]," Wailer said.
Bunny Wailer isn't the only member of the Rastafari community outraged by Snoop's new-found adherence to the religion. The Ethio-Africa Diaspora Union Millennium Council recently released a seven-page statement about his conversion, saying that, "smoking weed and loving Bob Marley and reggae music is not what defines the Rastafari Indigenous Culture!"
The Council is threatening to sue Snoop Dogg is he does not cease to use the name "Snoop Lion," make a public apology and pay fees to the group for financial and moral support.
RELATED: Snoop Dogg Launches Mind Gardens Initiative In Jamaica


text: I used the bugz zimlet as a starting point to do an item lookup. I changed the url to my own web page that responds with the required data. However, when I do the mouseover, it just says "fetching data". No tooltip is displayed. What causes this? The web page works if I try it outside of zimbra.


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BALTIMORE, Md. (WUSA9) -- A former employee at the Fort Meade Youth Center appeared in court on Wednesday on charges of sexually abusing a minor.
Anthony Dennis Williams II, 27, of Severn, worked at the Fort Meade Youth Center where he was a Child Youth and School-aged Services (CYSS) employee. Williams also taught a program at CYS called Passport to Manhood (P2M) which was a life course for juvenile males attending CYS, according to an affidavit.
Officials say that in 2010 and 2011 while he was working at CYS, Williams had sexually explicit conversations with the victims on social media and through text messages. They say he sent sexually explicit photos and videos to the minors.
The charges were announced Tuesday by United States Attorney for the District of Maryland Rod J. Rosenstein; Special Agent in Charge Stephen E. Vogt of the Federal Bureau of Investigation; and the U.S. Army Criminal Investigation Command.
"Parents must to be relentless about reading children's text messages and checking their social media accounts," said U.S. Attorney Rod J. Rosenstein. "Keep your children's passwords, read all of their incoming and outgoing messages, and take immediate action if they send or receive inappropriate messages."
The investigation is continuing.
Williams faces a maximum sentence of 15 years in prison for sexual abuse of a minor.


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Extreme Makeover: Home Edition
It all began with a television producer's phone call asking KraftMaid to help a deserving family in need of a fresh start. Seasons later, we are proud to remain the exclusive cabinetry provider of ABC's award-winning program, Extreme Makeover: Home Edition.
Episode 30The Vitale Family
Mom and dad are both SciFi geeks that met and fell in love at a gas station where they both worked. They have 2 sons, 3 and 1½. The 1½ year-old suffers from multiple birth defects, including Arthogryposis, club feet, and skeletal displasia; he is moved around in a wheelchair. He will have a lifelong disability and mobility problems, However he is a bright child with a loving spirit. His family is creative and supportive but, as you have seen, has limited resources and a home which is not adapted to his needs. Although he can't move very well, he loves to paint, so Mom started up Angel Boy Art, an organization that allows children to paint and auction off their work to raise money and awareness to their particular disease. The house that the family lives in was not built on a foundation that supports it, and engineers have said that one day, without warning, it will collapse and possibly kill everyone inside. EMHE will build this loving family a safe home in which they can care for their children and offer the medical therapy needed to improve both the child and parents' quality of life.


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Hey all
We have a new crew member here at Eastmans Scott Reekers.
Scott is going to be running the digital side of Eastmans.com. He will be here on the forum helping promote Eastmans social media including this forum out to the masses. Scott and I are working on getting the voting process ready for the contests and we will be working together to keep this forum the way we have all come to expect it, positive and full of respectful hunters willing to help.
Please welcome. Scott to the forum! He will introduce himself to you all soon and don't hesitate to ask questions to him. He is a great guy and ready to help in any way.
Thanks everyone!
Forum Moderator


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Ikard Wynne & Ratliff Llp, listed under "Attorneys" category, is located at 515 Congress Ave 1320 Austin TX, 78701 and can be reached by 5122757880 phone number. Ikard Wynne & Ratliff Llp has currently 0 reviews.This business profile is not yet claimed, and if you are the owner, claim your business profile for free. If you are not the owner you can invite this business to join by email or by phone.Browse all Attorneys in Austin TX. If you would like to see census data for this geographical location click here.
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This didn't prevent me from being an astute observer from the sidewalks of this interesting city.I'll get right down to it. I completely understand why there is such a massive Critical Mass movement in Budapest. Aside from a few scenic bicycle routes along the Danube and some isolated cycle spots downtown, cycling there is absolutely something for dare devils.
Budapest is completely clogged up with cars, and, to use an understatement, the roads don't exactly leave much room for pedaling. You have to share the road in a way that would make Paris look like Amsterdam. Even that is too much credit, really.
Nonetheless, its people do cycle, just not in droves as you'd hope for or in ways that would encourage others. Riding on sidewalks, even crossing the bridges while cycling close to the ramp, it's just nuts.
Here's what I came home with:
I've posted this video earlier this week, but I guessed it fits this post more, emphasizing what I took away from this vibrant city.


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e-Learning Success Worldwide
Intel® Education in classrooms around the world
Since Intel announced the Intel® classmate PC reference design in 2007, more than 10 million Intel classmate PCs have shipped globally. Intel® Education help schools worldwide with technology, digital educational content, professional teacher training, and infrastructure for ongoing support.
See how Intel® Education is benefiting students and teachers around the world.
Listen to education leaders discuss the benefits of implementing technology in classrooms to realize 21st century skills for students in their countries or read highlights here.
Argentina: Conectar Igualdad
Education Impact Research
Dr. Jason Beech, Dean of the School of Education - Universidad de San Andrés in Argentina, talks about the importance of closing the digital divide and social inclusion. He shares how change affects teachers and how to steer high school students toward academic use of the netbooks.
Education Impact Research
Olga Samardzic, formerly from the Primary Education Project in Macedonia and current consultant to the Macedonian Minister of Education, portrays the importance of teacher training and buy-in. She discusses how Macedonia has integrated technology to develop 21st century skills, particularly in rural schools.
Turkey: Kocaeli
Education Impact Research
Dr. Cengiz Hakan Aydin from Anadolu University in Turkey shares how government policies evolve based on constituents' needs and the use of netbooks at home and sometimes at school.
For more information
- Project RED conducts the first national research and advocacy plan to investigate how technology can help re-engineer education systems.
- Download the free guide: Transforming Education for the Next Generation
- Watch the education transformation video.
Education transformation
See result highlights from schools around the world >
Nigeria (2014) >
Nigeria >
Uganda >
- Read More
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Case Studies
Nigeria is bridging the digital divide to increase jobs, education, and economic opportunities.
Built for heavy usage, durable Intel® classmate PCs survived harsh desert conditions during marathon.
PRC: Shanghai
A primary school in Shanghai deployed a 1:1 learning pilot in partnership with Intel.
1:1 e-learning in Turkey improves education for school children with Intel® classmate PCs.


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We need your help in continuing the great afterschool program at the school, which is up for renewal. This program will continue to be FREE and will operate three hours after school as well as at other convenient times throughout the year. Please take a few minutes to tell us what activities the afterschool program should offer. The program will include food and snacks.
We value your opinion and feedback as we prepare the proposal. Thanks for your help.
Are you interested in continuing the free afterschool program at the school next year?
What types of activities would you like to see or continue to see in the program? (Please check up to five, or type in your suggestions below.)
How many days of the week would you want to participate in the afterschool program? Please check the days you can attend.
How safe do you feel when you are in school? Please check the answer that best fits your opinion.
Would bus transportation at the end of the afterschool program each day be helpful?
How safe do you feel in the after school hours from 3:00 to 6:00 pm? Please check the answer that best fits your opinion.
How safe do your friends feel after school from 3:00 to 6:00 pm?
Thanks for completing! After you click Finish, it will return to the beginning of the survey for the next person.


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Role of Mitochondria in Self-Renewal Versus Differentiation of Human Embryonic Stem Cells
Human embryonic stem cells (hESCs) hold great potential for treating multiple human dread diseases, including but not limited to cancer, diabetes, obesity, Alzheimer disease, and certain types of heart failure. However, a growing appreciation exists for the notion that not all hESCs have identical capabilities in correcting or ameliorating disease and not all hESCs will be valuable as potential therapeutic cell sources. Because hESCs contain genetic information like all human cells, some hESCs will have genetic mutations or alterations that will make them more or less desirable for therapy. The heritable information contained with hESCs comes from DNA in the cell nucleus and also from DNA within maternally inherited mitochondria. In fact, it is the functional capabilities of mitochondria in hESCs that this proposal addresses because over 400 mutations in mitochondrial DNA result in disease and many more disorders associated with mitochondrial dysfunction, often unidentified at the molecular level, arise from mutations in nuclear DNA.
It is potentially dangerous that so little is known about the functional capabilities and role for mitochondria in hESCs and in the major decisions that hESCs make, such as whether to self-renew and make more stem cells or to differentiate into any one of the known human lineages, including muscle, skin, brain, and other cell types. We anticipate the day when stem cell therapies to combat disease or provide replacements for worn out components will be a main part of individualized medical treatment. We believe it is therefore critical to choose the best stem cell starting materials for such therapeutic applications. This view, combined with a desire to understand how mitochondria, as the main source for a cell's energy and building block generation, functions in stem cell decisions, propels us to provide 3 integrated areas of specific investigation into stem cell mitochondria and their role(s) in decision making. Our studies will evaluate basic mitochondrial functions and structures in a variety of hESCs to gain an appreciation for variability in distinct hESCs (Aim 1). We will alter mitochondrial function in hESCs with genetic and environmental insults to gain an appreciation for the global effects on hESC function and as a way to help select appropriate stem cells for future therapeutic applications (Aim 2). We will force hESCs with normal or altered mitochondria to differentiate into germ cells, blood cells, skin cells, or brain cells with expert collaborators in each lineage type to evaluate how the state of mitochondrial function will dictate the ability for hESCs to provide multiple, distinct replacement lineages for use (Aim 3).
In sum, we expect our studies will reveal the critical role for mitochondria In stem cell biology and this new knowledge and our analytical approach will help provide essential information for choosing optimum stem cells for future therapeutic applications.
Our proposal will benefit California by adding new knowledge on the functional capabilities of human embryonic stem cells (hESCs) and their lineage differentiated derivatives, which will support the California peoples' and taxpayers' commitments to individualized medical treatments of the near future. It will help us select the best possible stem cells for study and therapy development in our major academic centers and will provide information to many of California's biotechnology and pharmaceutical companies in the burgeoning stem cell industry, whose success will propel hiring and increased economic prosperity for the state. Our work will provide additional information to patient advocates, ethicists, and even (eventually) medical geneticists to help select the optimal course for developing and modifying stem cell usage policies and infrastructure within California. This proposal will provide information for patients and their physicians, that may, at some future time, impact the selection of particular stem cell attributes for specific types of therapeutic applications. In sum, the added knowledge provided by a detailed analysis of mitochondrial capabilities in hESCs will have tangible health and economic impact on California, its academic institutions and biotechnology/pharmaceutical companies, and the rest of the nation as California and its people move forward with personalized medicine during the 21st century.
Stem cell quality and safety for regenerative medicine therapies is of utmost importance. Poor outcomes include inadequate functionality, exhaustion, immune rejection, cancer development, and others. Recent studies strongly support our core hypothesis that mitochondrial function determines stem cell quality and safety. Dysfunctional mitochondria foster cancer, diabetes, obesity, neurodegeneration, immunodeficiency, and cardiomyopathy. Unlike whole genome approaches, methodological hurdles for evaluating mitochondria in human embryonic stem cells (hESCs) and in reprogrammed human induced pluripotent stem cells (hIPSCs) are significant and techniques developed or adapted for stem cells are almost non-existent. With this 2-year CIRM Seed Grant, we developed new approaches for analyzing respiration (oxygen consumption that drives energy production) in hESCs and hIPSCs in a series of 4 invited publications for the stem cell scientific community (www.JoVE.com; 2008). We showed that mitochondria are capable of respiring and utilizing oxygen for energy generation but do this at a very limited level compared to mature tissue cells of an adult. We speculate that this is because the cells from which hESC are derived exist physiologically in a low oxygen environment and require a switch to be turned on to facilitate oxygen consumption during development. We are working hard on understanding this switch and believe we have one of the components identified. We showed that mitochondria in reprogrammed hIPSCs are not completely reset to the embryonic state seen in hESCs, which may have implications for the use of hIPSCs in regenerative medicine. A manuscript describing the function of hESC and hIPSC mitochondria in low oxygen tension (hypoxia), in normoxia (room air), and during differentiation is being prepared for manuscript submission. We also collaboratively developed small molecule inhibitors of specific mitochondrial functions, thereby providing new essential tools to the scientific community for interrogating the function of stem cell mitochondria- this work is being continued under a new funding mechanism from CIRM. Unlike current inhibitors of mitochondrial function, with are generally non-specific, irreversible, and toxic over time, our novel inhibitors are reversible, non-lethal, and target a range of specific mitochondrial functions. These inhibitors are undergoing continuous molecular refinement and validation studies for use in basic studies and can potentially lead to insights for clinical application in common diseases, such as diabetes and cancer. They may also find utility in interrogating hESC and hIPSC mitochondria function to pick the best stem cell lines for developing future cellular therapies.
- Stem Cell Reports (2014) Defining the role of oxygen tension in human neural progenitor fate. (PubMed: 25418722)
- Nat Methods (2014) Live-cell mass profiling: an emerging approach in quantitative biophysics. (PubMed: 25423019)
- Methods Enzymol (2014) Techniques to monitor glycolysis. (PubMed: 24862262)
- Dev Cell (2013) A small molecule inhibitor of redox-regulated protein translocation into mitochondria. (PubMed: 23597483)
- Biophys J (2013) Quantification of biomass and cell motion in human pluripotent stem cell colonies. (PubMed: 23931307)
- Proc Natl Acad Sci U S A (2012) Correcting human mitochondrial mutations with targeted RNA import. (PubMed: 22411789)
- Nat Protoc (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. (PubMed: 22576106)
- Cell Stem Cell (2012) Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal. (PubMed: 23122286)
- Stem Cells (2011) Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. (PubMed: 21425411)
- EMBO J (2011) UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. (PubMed: 22085932)
- Lab Chip (2010) Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. (PubMed: 20390128)
- Cell (2010) PNPASE regulates RNA import into mitochondria. (PubMed: 20691904)
- Stem Cells (2009) Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells. (PubMed: 19350678)
- Stem Cells (2009) A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. (PubMed: 19224508)
- Cell Stem Cell (2009) Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. (PubMed: 19570518)
- J Vis Exp (2008) From MEFs to Matrigel 2: splitting hESCs from MEFs onto Matrigel. (PubMed: 19066543)
- Nature Reports Stem Cells (2008) How to Assess a Stem Cell Genome
- J Vis Exp (2008) From MEFs to matrigel I: passaging hESCs in the presence of MEFs. (PubMed: 19066554)
- J Vis Exp (2008) From MEFs to Matrigel 3: passaging hESCs from Matrigel onto Matrigel. (PubMed: 19066542)
- Stem Cells (2008) Copy number variant analysis of human embryonic stem cells. (PubMed: 18369100)
- J Vis Exp (2008) Probing for mitochondrial complex activity in human embryonic stem cells. (PubMed: 19066553)
- Cancer Cell (2007) Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. (PubMed: 18068633)


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It's a wonderful co-incidence and one worth sharing:
As video clips of last year's Manchester "Big Tent for Israel" advocacy conference become available (http://www.youtube.com/playlist?list=PL5828274701A64CEA) comes another containing an extraordinary admission from US-Jewish anti-Israel academic, Norman Finklestein.
While he continues to spout his customary anti-Israad rhetoric ad nauseum, Finklestein also admits that he is sick of Boycott, Divestments and Sanctions measures which he describes as 'dishonest' and a 'cult'. The original clip was more than 30 minutes in length and has been shortened by the editors of the Huffington Post Monitor. The revised transcript below was published by Adam Levick at CFI Watch:
"I've earned my right to speak my mind, and I'm not going to tolerate what I think is silliness, childishness, and a lot of leftist posturing.
"I mean we have to be honest, and I loathe the disingenuous. They don't want Israel. They… Read more


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Vacation Bible School July 15-19 at Island Alliance church
Friday, 19 July, 2013|
Vacation Bible School July 15-19 from 5:45-8:30 pm at Island Alliance Church 510 Thompson Creek Road, Stevensville (Kent Island) MD. All are welcome who have completed Pre-K through grade 6. Register at www.islandalliancechurch.com or call 410-643-5683. Free and open to the public.
Island Alliance church
510 Thompson Creek Road
Stevensville, MD 21666
Stevensville, MD 21666
Event ContactSue Klakring
Phone: 410-643-5683
Website: Click to Visit


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Take steps today to lower your risk of heart disease and heart attack. Heart disease is the leading cause of death for both men and women in the United States.
To help prevent heart disease, you can:
You are at higher risk for heart disease if:
As you get older, your risk for heart disease and heart attack increases. But the good news is that heart disease can be prevented.
When people talk about heart disease, they are usually talking about coronary heart disease (CHD). It's also called coronary artery disease (CAD). This is the most common type of heart disease.
When someone has CHD, the coronary arteries (tubes) that take blood to the heart are narrow or blocked. This happens when cholesterol and fatty material, called plaque ("plak"), build up inside the arteries.
Plaque is caused by:
When plaque blocks an artery, it's hard for blood to flow to the heart. A blocked artery can cause chest pain or a heart attack. Learn more about CHD.
A heart attack happens when blood flow to the heart is suddenly blocked. Part of the heart may die if the person doesn't get help quickly.
Common signs of a heart attack include:
Not everyone who has a heart attack will have all the signs. Learn more about the signs of a heart attack.
Signs of a heart attack often come on suddenly. But sometimes, they develop slowly – hours, days, or even weeks before a heart attack happens.
Talk to your doctor if you feel tired for several days, or if other health problems (like pain or trouble breathing) bother you more than usual.
Don't ignore any signs or feel embarrassed to call for help. Acting fast can save a life. Call 911 even if you aren't sure it's a heart attack.
An ambulance is the best and safest way to get to the hospital. In an ambulance, EMTs (emergency medical technicians) can keep track of how you are doing and start life-saving treatments right away.
People who call an ambulance often get treated faster at the hospital. And, if you call 911, the operator can tell you what to do until the ambulance gets there.
Take steps today to lower your risk for heart disease.
High blood pressure and high cholesterol can cause heart disease and heart attack. If your blood pressure or cholesterol numbers are high, you can take steps to lower them.
Men need to get their cholesterol checked at least once every 5 years. Women at risk for heart disease need to get their cholesterol checked once every 5 years. Talk with your doctor about getting your cholesterol checked.
Starting at age 18, get your blood pressure checked regularly. High blood pressure has no signs or symptoms.
Use the myhealthfinder tool to get more screening recommendations based on your age and sex.
Your family history affects your risk for heart disease. Use this family health history tool to keep track of your family's health. Share the information with your doctor or nurse.
If you are worried about a family member's risk for heart disease, use these tips to start a conversation about heart health.
Daily aspirin can reduce your risk of heart attack or stroke by preventing blood clots. A blood clot can cause a heart attack or stroke if it blocks the flow of blood to your heart or brain.
Aspirin is not recommended for everyone. Talk with your doctor to find out if taking aspirin is the right choice for you.
Eating healthy can help lower your risk of heart disease. A heart-healthy diet includes foods that are low in saturated and trans fats, added sugars, and sodium (salt).
Heart-healthy items include high-fiber foods (whole grains, fruits, and vegetables) and certain fats (like the fats in olive oil and fish). Use this shopping list to find heart-healthy foods.
Check out these heart-healthy recipe collections:
Get heart-healthy tips for dining out [PDF - 3 MB]. For example, ask for a side salad instead of chips or french fries.
If you choose to drink alcohol, limit your drinking to no more than 1 drink a day for women and no more than 2 drinks a day for men. Drinking too much can increase your risk of heart disease.
Getting active can help prevent heart disease. Adults need at least 2 hours and 30 minutes of moderate aerobic activity each week. This includes walking fast, dancing, and biking.
If you are just getting started, try walking for 10 minutes a day, a few days each week. Then add more activity over time.
Extra weight can lead to high cholesterol, high blood pressure, and type 2 diabetes. If you are overweight or obese, losing just 10 pounds can lower your risk of heart disease. Find out how to control your weight.
If you don't know if you are at a healthy weight, use this BMI calculator to figure out your BMI (body mass index).
Quitting smoking helps lower your risk of having a heart attack. Call 1-800-QUIT-NOW (1-800-784-8669) for free support and to set up your plan for quitting.
Managing stress can help prevent serious health problems like heart disease, depression, and high blood pressure. Deep breathing and meditation are good ways to relax and manage stress.
When you have diabetes, there is too much glucose (sugar) in your blood. Over time, if it's not controlled, diabetes can cause serious health problems, including heart disease.
Taking steps to prevent type 2 diabetes – like eating healthy and getting active – can help keep your heart healthy.
Content last updated on: March 29, 2016
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Explore the Entrepreneurship.org Resource Center to find resources. Designed with entrepreneurs in mind, our resource center allows you to find materials to grow great ideas.
Part 2 of 2: Thom Ruhe speaks on entrepreneur/CPA/lawyer/author Lou Hutt's popular XM Radio show discussing various matters related to entrepreneurship, the Kauffman Foundation, the E=R Campaign and our current business/economic climate.
Numenta's Jeff Hawkins, a frequent company founder, inventor, and product designer for Palm and Handspring, highlights lessons learned during his tenure in technology. He also confesses that these accomplishments were mere way stations in his 30-year passionate pursuit of neuroscience.
In academia and the private sector, innovation is the most elusive element. And, adds Stanford University President John Hennessy, it's also needed to solve crucial local and global issues. In this address that launches the University's prestigious Entrepreneurship Week event, Hennessy discusses the evolving interplay between higher learning and commercial progress.
Beth Seidenberg, partner at venture firm Kleiner Perkins Caufield & Byers, speaks at length about KPCB's current areas of interest, and its litmus test for projects worth supporting. Seidenberg also offers a case study of a life sciences firm moving from research lab toward market.
David Rothkopf, CEO of Garten Rothkopf and author of Superclass: The Global Power Elite and the World They are Making, mulls over the research in his latest social macroeconomic tome. He iterates a wealth of trends and statistics on the ever-broadening gap between rich and poor, and how true global influence is the product of a shockingly small handful of global players.
Larry Bawden is a co-founder of Jadoo Power, an innovative supplier of fuel cells, and Q1 Nanosytems, a next-generation photo-voltaics provider. Bawden addresses the new landscape in technology and energy and notes the pivotal role of newer technologies in the global economy. He talks about the four fundamental planetary crises - Global Warming, Peak Oil, Population Peak and Resource Depletion that are driving changes in world. Bawden also acknowledges the rise of third generation technology and the fundamental shifts in business that it has created. He believes that these changes have created a favorable environment to launch new ventures.
Prominent industry leaders team up with Stanford Faculty to discuss entrepreneurial solutions to problems in the areas of international affairs, human health and the environment. They tackle world issues from a global and technical perspective beyond the usual bureaucratic approach with a special focus on developing nations.
Steve Burrill, CEO of Burrill & Co., provides an overview of the life sciences industry, reflecting on insights he has gained throughout his career. Along the way, he shares his laws of survival and anecdotes that relate the keys to his success in the areas of biotechnology, venture capital and merchant banking.
Kathy Eisenhardt, co-director of Stanford Technology Ventures Program and professor in Management Science and Engineering, shares results from her research regarding successful ventures, addressing fundamental issues such as team building, market creation and financing.
Want to get connected? Sign up to receive regular news, polls and updates from The Kauffman Foundation.
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Agency FB
ATF Agency Gothic was designed by Morris Fuller Benton in 1932 as a lone titling. In 1990, David Berlow saw potential in the squared forms of the narrow, monotone capitals. He designed a lowercase and added a bold to produce Font Bureau Agency, an immediately popular hit. Sensing strengths that surpassed those of a useful condensed, Font Bureau developed Agency into a major series offering five weights in five widths; FB 1990–95
Among other uses, Agency FB is recommended for Magazine, Book, Web and Corporate use.
Similar Fonts· Interstate
Related People· David Berlow
Related Galleries· Road & Track


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Rated 5 out of 5 by 2 reviewers.
Rated 5 out of 5 by savvy shopper Delighted with my purchase I was impressed by the quality and design of this screen for the price. It has nicely filled in a previously empty corner of my living room, making the space more inviting. The architectural elements also added much needed style to my room. I am happy with this purchase. June 18, 2012
Rated 5 out of 5 by PT Double Duty Beaut This screen proved to be a beautiful and easy-to-use replacement for the queen-size headboard in our master bedroom. Comes fully assembled in a box. Just take it out and it's ready to go. The 25% discount made it an even better deal. November 9, 2011
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May 31, 2016
The Lauderdale County Sheriff's Department says it is investigating a stabbing at a prison this weekend.
Investigators say an inmate at the East Mississippi Correctional Facility in Lost Gap was stabbed sometime on Saturday evening. The victim did not sustain any life-threatening injuries.
Authorities say one or more suspects are in custody. A motive is unknown at this time.
Investigators say they are in the process of gathering facts about the incident.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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Candy experts and historians agree that there are some candy bars that have had a bigger impact on the chocolate bar industry than others. Take a look at the most influential candy bars of all time, compiled by Time.com.
12. Wonka Bar
After the success of the iconic1964 Roald Dahl novel, the Quaker Oats Company decided to make the Wonka Bar a reality. This marked the first time a fictional candy bar had come to life.
11. Milky Way
This was the first to take inspiration from an actual dessert: the milky way malted milkshake. Decades later, that same gimmick would spawn products like PowerBar's Dulce de Leche-flavored snack and Kit Kat's Strawberry Cheesecake bar in Japan.
10. Baby Ruth
Launched in 1921, its makers claimed it was named after President Grover Cleveland's daughter Ruth (who had died 17 years earlier at the age of 12). But at that time, the more obvious association was with new Yankees star Babe Ruth, making this the first candy bar to profit from the success of a public figure.
9. Nestle Crunch
Prior to this bar's introduction in 1937, candy-bar fillings were somewhat rich: nuts, caramel, etc. By using dirt-cheap puffed rice, however, Nestle helped mainstream the notion that candy could be almost anything you put into chocolate.
8. Cadbury Milk Chocolate
The Cadbury family's legendary factory village in Birmingham, England—where these bars were created in 1897—helped inspire Milton S. Hershey's own facility in Pennsylvania.
7. Scharffen Berger
The world's first widely distributed "artisanal" chocolate bar was acquired by Hershey in 2005 and set the stage for the artisanal chocolate bar movement.
6. Grenada Chocolate
Grenada Chocolate, founded in 1999, is unique because its cocoa beans are grown and processed into bars entirely within its home country, helping boost the economy and providing employment for locals.
5. Chicken Dinner
Making it's debut in 1923, Chicken Dinner was the first chocolate bar to be marketed as nutritious; advertisements touted the nut-packed treats as "candy made good." Its success helped pave the way for the power bar industry.
4. Snickers
More than 80 years after its launch in 1930, this Mars bar is world's best-selling international candy bar. Its star-studded ad campaign "You're Not You When You're Hungry" helped sales hit around $3.5 billion in 2012, outpacing M&Ms, Reeses and Kit Kat.
3. Toblerone
The iconic triangular prism of chocolate, nougat, almonds and honey, which debuted in 1908, was the first flagship bar to debut with a filling, upending the traditional model.
2. Hershey's Milk Chocolate
Nestlé may have invented milk chocolate, but Hershey's made it mainstream.
1. Kit Kat
The first candy bar to be marketed around sharing, which helped turn chocolate into a social snack, Kit Kat was also the first to gain a global following. The wafer-filled Kit Kats launched in both Europe and the U.S. before entering Australia, Asia and Africa—paving the way for other blockbuster bars like Snickers and Butterfinger.
To read more about the most influential candy bars, click here.
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Powerwinch 712 / 912 Trailer Winch
Key Features
Power in/freewheel out operation
Smooth pulling action
Resists snarls and cable wear
Includes quick-mount kit
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Product DescriptionRemote power-in/freewheel-out operation. Positive lock when not winding. Easily operated with Tri-Matic Roll-n-Gage control. Efficient gear train system for smoother pulling action and less amperage draw. Level wind system prevents snarls and cable wear. Aircraft quality cable fitted with safety hook and ABS weather-resistant housing. Comes with simple to install wiring harness. Hooks to any 12V auto or truck battery in minutes. Optional ball hitch adapter plate allows unit to mount to any vehicle ball for portable winch.


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Coffee drinkers who worry about the jolt of java it takes to get them going in the morning might just as well relax and pour another cup.
That's according to the largest-ever analysis of the link between coffee consumption and mortality, which suggests that latte lovers had a lower risk of death during the study period.
"I would say it offers some reassurance to coffee drinkers," said Neal Freedman, a nutritional epidemiology researcher at the National Cancer Institute. "Other studies have suggested a higher risk of mortality with coffee drinking and we didn't see that in our study."
In fact, men who drank at least six cups of coffee a day had a 10 percent lower chance of dying during the 14-year study period than those who drank none. For women, the risk was 15 percent lower, according to Freedman's work, published in the latest issue of the New England Journal of Medicine.
Reassuring, indeed, for hard-core coffee drinkers like Spencer Turer, who guzzles four to six cups of coffee every day for personal consumption -- and sips between 75 and 300 cups more as part of his job as a professional coffee taster.
"It's good news for all coffee drinkers because we can feel really good about the decisions we're making," said Turer, director of coffee operations for the firm Coffee Analysts, which provides unbiased scientific review of coffee products. "People concerned about the health effects may choose to drink more coffee."
Overall, in the U.S. about 64 percent of adults drink coffee daily, according to Joe DeRupo, spokesman for the National Coffee Association. At 3.2 cups a piece, that amounts to some 479 million cups a day, agency figures indicate.
Those coffee fans can take the new results seriously. The mortality reduction is modest but solid, said Freedman, whose study offered the size and power to document associations other researchers had only suspected.
He and his team in NIC's Division of Cancer Epidemiology and Genetics reviewed the coffee habits of more than 402,000 people followed between 1995 and 2008, including more than 52,000 who died.
They included some 229,000 men and more than 173,000 women ages 50 to 71 who agreed to take part in the NIH-AARP Diet and Health Study, which tracked comprehensive lifestyle questionnaires filled out by people in six states and two metropolitan areas.
Freedman's analysis centered on healthy people; those with cancer, heart disease and stroke were excluded from the review.
"We didn't know what to expect," recalled Freedman. "There have been a lot of studies and the results have been mixed."
Previous studies suggested that coffee might contribute to heart disease; others found similar results to Freedman's, that coffee actually cut the risk of death. Initially, even Freedman's study indicated a higher risk of death among coffee drinkers, but only because so many of them smoked cigarettes, too.
"It was only after we took into account people's smoking that the association, the inverse association, revealed itself," he said. "Smoking has a really strong association with death."
Drinking six or more cups of coffee a day cut mortality risk the most, but not by much. People who drank between two and five cups of coffee daily also appeared to have lower risk, the study showed. Whether the coffee contained caffeine or not didn't seem to matter.
It's not clear whether -- or where -- the mortality effect tops out, but Freedman wasn't advising anyone to gulp 12 cups a day to test the theory.
The link to lower mortality held up whether researchers considered total deaths or deaths from specific diseases and other causes – except for cancer. When it came to cancer, deaths were slightly higher among male coffee drinkers.
Why? "We don't know," Freedman said.