text:
De Maar takes stage, adds to overall lead at Mt. Hood
- By Neal Rogers
- Published Jun. 4, 2010
- Updated Jun. 5, 2010 at 11:17 AM EDT
- The trees show that life in the Gorge is often windy.
- Smooth roads.
- Last year's TT winner Chris Baldwin suffered a mechanical and lost time.
- Late spring in Oregon.
- The course finished up on a beautiful bike/pedestrian path.
- De Maar proved himself worthy of the jersey. | Photo courtesy UnitedHealthcare-Maxxis
UnitedHealthcare-Maxxis rider Marc de Maar may have inherited the Indie Hops Mt. Hood Cycling Classic race leader's jersey in an undesirable fashion on Thursday's stage 2 road race, but the Dutch rider established himself as the strongest man at the race Friday during a windy 18.5-mile time trial.
After taking the top spot on GC when his teammate Morgan Schmitt was penalized 20 seconds for drafting back from a puncture, de Maar came out swinging Friday morning. Pushing into a mix of cross- and headwinds, De Maar's time of 44:06 was 14 seconds faster than 2009 overall winner Paul Mach (Bissell), who finished second.
"It was a hard time trial," de Maar said. "I never felt really good, I was always suffering. Normally on a flat time trial you can get into a rhythm. But here it was all up or down, and even when it was down there were headwinds. I was suffering a lot."
Riding without team support, Team Type 1's Mike Creed finished third on the stage, 36 seconds off de Maar's time; Creed now sits fourth on GC, 44 seconds down.
"It was a little bit of crosswind, but mostly headwind." Creed said. I think it's the best time trial course in America. It's point-to-point, it has a switchback climb, a valley… a little bit of everything. It's one of the most technical, one of the hardest. It's a sweet TT course."
Hagens Berman rider Sam Johnson finished fourth on the TT, 39 seconds behind de Maar, and now sits third overall, 42 seconds back. Schmitt finished the stage eighth, 1:35 back, and now sits seventh overall.
Last year's overall runner-up Chris Baldwin finished 54th, 4:17 down after a mechanical problem left his rear disc wheel rubbing his frame. It was a major disappointment for the national TT champion, who won this stage one year ago in his first race for OUCH-Maxxis after jumping ship from Rock Racing.
"It sucks, but that's how it goes," Baldwin said. "Anyhow, Marc is riding better than I am right now, so he's our best shot at the GC win."
While de Maar and Mach are poised to battle for the overall win, Creed admitted he had no major goals coming to Mt. Hood without a team. "I really don't have an objective," he said. "It's better than sitting at the house. I'd rather race than just train. I'm just here to race my bike and see what happens."
Asked why he was racing at Mt. Hood while the rest of his Team Type 1 squad was racing the Philadelphia International Championship, Creed said team director Vassili Davidenko or team manager Phil Southerland would better answer that question.
Mach and de Maar started the day tied on GC, meaning Mach will start Saturday's stage 4 road race 14 seconds back, the same difference as on Friday's TT stage.
"There was more crosswind than last year," Mach said of the time trial. "Last year was block headwind, just kind of grind away, today you had to keep your eyes open or one of the crazy gusts could blow you off the road."
Asked about his form compared to in 2009 when he won the overall, Mach said, "I was surprised I am doing so well. After the Tour of California I was beat. But I rested up, and I guess I am doing okay. I'd say my form is pretty similar to last year. I think after the Tour of California it's safe to say de Maar is clearly a good rider. It's no surprise he's doing well here."
Mach's situation is a near mirror-reversal of one year ago, when he held a 13-second lead heading into the Wy'East Road Race, which features a 35-mile grind up 4500 feet of elevation to the Mt. Hood Meadows Ski Resort for the finish. Though it's a long climb, its highway gradient makes it tough to open gaps, particularly if it's windy.
"Last year the situation was a bit reversed with Baldwin sitting 13 seconds down on me, and he was having a hard time (on the climb)," Mach said. "Now the situation is turned around. We'll race and see what happens."
De Maar said he was confident his UnitedHealthcare-Maxxis team is the strongest in the race. "Today we started with three in the top five," he said. "We lost Chris (on the GC) because of some problems with his bike, but we're going to kick ass again tomorrow."
1. Marc Demaar (USA) Unitedhealthcare Presented By Maxxis, 44:20.2
2. Paul Mach (USA) Bissell Pro Cycling at 0:14
3. Michael Creed (USA) Team Type 1 at 0:36
4. Sam Johnson (USA) Hagens Berman Cycling at 0:39
5. Nathaniel English (USA) Echelon Gran Fondo/z-Team at 1:01
6. Jesse Moore (CAN) California Giant Berry Farms/specialized at 1:02
7. Kevin Rowe (USA) Team Exergy at 1:30
8. Morgan Schmitt (USA) Unitedhealthcare Presented By Maxxis at 1:35
9. Adam Switters (USA) Yahoo! Cycling Team at 1:41
10. Robert Britton (USA) Bissell Pro Cycling at 1:46
Top-10, GC
1. Demaar Marc (USA) Unitedhealthcare Presented By Maxxis, 6:43:14
2. Mach Paul (USA) Bissell Pro Cycling at 0:14
3. Johnson Sam (USA) Hagens Berman Cycling at 0:42
4. Creed Michael (USA) Team Type 1 at 0:44
5. English Nathaniel (USA) Echelon Gran Fondo/z-Team at 1:10
6. Moore Jesse (CAN) California Giant Berry Farms/specialized at 1:20
7. Schmitt Morgan (USA) Unitedhealthcare Presented By Maxxis at 1:47
8. Britton Robert (USA) Bissell Pro Cycling at 1:57
9. Switters Adam (USA) Yahoo! Cycling Team at 1:59
10. Hamilton Nic (CAN) Trek Red Truck at 2:03
De Maar on course
De Maar proved himself worthy of the jersey. | Photo courtesy UnitedHealthcare-Maxxis
The course finished up on a beautiful bike/pedestrian path. | Pat Malach Photo
Late spring in Oregon.| Pat Malach Photo
Last year's TT winner Chris Baldwin suffered a mechanical and lost time.| Pat Malach Photo
Smooth roads. | Pat Malach Photo
The trees show that life in the Gorge is often windy. | Pat Malach Photo
FILED UNDER: News / Race Results / Road TAGS: Marc de Maar / Mt. Hood Cycling Classic


text:
Andie's husband wants to adopt her son. Andie tells Philip Boucher Hayes how shocked she was to learn that during this process she would also have to adopt her own son. More callers talk about their experiences of adoption in Ireland.
Una said goodbye to her daughter, son-in-law and 3 grandchildren yesterday as they returned to their home in Dubai. Una is angry and upset that her family has been forced to emigrate for work.
Michelle's 15-year-old son started Transition Year this week. Although her son is young he is very academic and Michelle is concerned that he might lose his focus during the year. Callers debate the merits of Transition Year.
Brian is upset that a boat decorated with flowers in Malahide has been vandalised twice since it was erected 6 weeks ago.

subset: commoncrawl


text:
As hard as outsiders have tried to subdue and "re-create" the country in their own image,
Afghanistan has been able to absorb the blows of superpowers, and
remain essentially the same.
The interesting thing is that the people trying to change it,
change more than the country does even after
Herculean efforts of governments, NGO's, and coalitions.
The road to hell is paved with good intentions.
The problem is that intentions which are based on faulty and naive
assumptions are doomed to failure.
Mujahadeen head toward Kabul as Russians leave
In spite of the failed attempt by the powerful Soviet army
to bring the country under its control,
the "deciders" still had the fantasy that we could do what
hadn't been done before.
Those "deciders" did not have even the basic
understanding of the country, the history, the people,
the terrain, the language, the religion, the culture.
Mujahadeen holds up decapitated head of Afghan Army soldier
Lieut. Col. Daniel Davis, in an analysis of the situation in Afghanistan titled, "Truth, Lies,
and Afghanistan" published in The Armed Forces Journal in February, 2012, wrote,
"I witnessed the absence of success on virtually every level"
in his rebuttal to the military's assertion that the war was going well and that the Coalition
was making progress. He charged the military leadership with misleading
the American public.
Davis reported that he had repeatedly seen top commanders
falsely dress up dismal situations including
General Petreus in testimony to Congress.
During the months I traveled with the Mujahadeen, I witnessed a deep camaraderie
amongst the fighters who were on the greatest mission of their lives.
They weren't looking at the calendar.
They didn't even worry much about casualty numbers.
The harder the fight was, the stronger they became.
Mujahadeen with family members cross into Pakistan
Walking in the snow without boots high up in the Hindu Kush was commonplace.
Those men were as tough as it gets.
Every gun that is made, every warship launched, every rocket fired signifies,
in the final sense, a theft from those who hunger and are not fed, those who are cold and not clothed.
This world in arms is not spending money alone. It is spending the sweat of its laborers,
the genius of its scientists, the hopes of its children.
This is not a way of life at all in any true sense.
Under the cloud of threatening war, it is humanity hanging from a cross of iron.
– Dwight David Eisenhower
Former Soldier in Makeshift Mental Hospital


text:
by Jeff Spross Dec 31, 2013
Between extensions, subsidies, and the Medicaid expansion, only a minute fraction of Americans will truly lose health insurance coverage in 2013.
by Zack Beauchamp Dec 31, 2013
A new poll finds a big drop in Republican acceptance of evolution, which tells us some very interesting things about the future of the GOP.
Ken Langone and others are worried Francis' remarks will turn off wealthy donors to the Catholic Church.
by Matt Duss Dec 31, 2013
Israeli Prime Minister Benjamin Netanyahu often says Iran's new charm offensive is a ruse. But his military's intelligence agency doesn't think so.
by Lauren C. Williams Dec 31, 2013
Before we ring in the New Year, let's take a look at how your personal data's privacy and security was compromised in 2013.
by Igor Volsky Dec 31, 2013
A low minimum wage prevents families from "interacting with one another" and building relationships within their communities, Iowa state Sen. Jack Hatch, says.
A decade after the military realized they weren't terrorists, these members of a viciously repressed minority are finally being granted their freedom.
"Maybe let your bosses know that those of us who are not married to June Cleaver find this deeply insulting," one passenger tweeted at Air Canada.
by Emily Atkin Dec 30, 2013
It was unclear late Monday whether food that had already been grown on that land would be sought out or recalled.
by Tara Culp-Ressler Dec 30, 2013
Minnesota is preparing to begin randomly drug testing its welfare recipients, a policy that could actually cost taxpayers money.


text:
C/2007 N3 (Lulin) Obs. 12.30.08
Posted 30 December 2008 - 09:44 AM
There's a comet beginning to make an appearance for northern hemisphere observers--it might become a bright one. I made this sketch and observation early this AM and posted it in the Solar System and Planetary Observing forum.
I worked with HB and 2B pencils and a stump on white Artagain sketch paper and inverted things digitally (also applied 5% blur).
It was cold and I can't sketch with gloves usually, so I kept a HotHands chemical warmer in the muff I wear around my midsection and was able to keep my fingers functioning.
Let me know what you think.
Posted 30 December 2008 - 06:57 PM
Very nice sketch of this early morning comet. Your techniques always impress me and work so very well. I know what you mean about sketching in the cold, below 25 degrees F I start having trouble with numb fingers. This comet will be fun to follow.
Posted 31 December 2008 - 08:33 AM
Posted 31 December 2008 - 12:35 PM
Frank, try the handwarmers--it's really nice to have something hot to grab onto when your hands start to chill and it puts the feeling right back into my fingers.
Happy New Year, everyone!
Posted 31 December 2008 - 03:33 PM
An excellent observation of this interesting new comet. I hope that it does brighten for all of us to follow it. Thank you for sharing it with us all.
Happy New Year!
http://ssd.jpl.nasa....=1;sstr=2007 N3
Posted 31 December 2008 - 06:08 PM
Thank you for the compliment and for the very interesting links. Here's to a bright comet for the New Year!
Posted 31 December 2008 - 06:16 PM
Posted 01 January 2009 - 11:00 AM
I took another look at our icy visitor from the outer reaches of the solar system and made this update to my sketch.
Posted 01 January 2009 - 03:15 PM
Thank you for the update on Comet C/2007 N3 (Lulin). I look forward to observing this comet soon.
Posted 03 January 2009 - 09:50 AM
I made a new observation and sketch this morning posted here. Media were the same.
Posted 03 January 2009 - 03:42 PM
Very nice sketch! I just posted to another link with your sketch where Rev Aaron had started the post to alert observers. It looks as if from projected charts that the comet could reach peak brighteness in February as it moves from Virgo toward Leo and close to Saturn.
I noticed that it is difficult to find dates or RA ~ DEC on comet posts in the web as I am always curious to know, where exactly is it in the sky currently? And why no dates in these sites? I would think that astronomers would be the most astute about posting dates especially as comets positions change constantly. The three sites that Carlos listed are useful though; Thanks Carlos!
http://ssd.jpl.nasa....=1;sstr=2007 N3
I found a nice rough and fine charts but again no dates >
Thanks again to all for the heads up; I'll look forward to observing the comet, as weather permits,
Posted 03 January 2009 - 08:35 PM
If you go to this Ephemeris site
http://www.cfa.harva...ets/2007N3.html you will find below the orbital elements a good Ephemeris which includes RA and Dec for selected dates throughout the year. Using a transparent film you can plot these on your favorite star chart for locating on any date by extrapolation. The Heavens above site you copied above gives the coordinates for the date and time you are looking. Look at the data under the first image. I hope this helps.
Posted 03 January 2009 - 08:46 PM
Nice update to the sketch sequence you have started. I may need to wait a few more days to get a clear morning and a look for myself. Keep going if you can.
Posted 03 January 2009 - 11:59 PM
Frank, thanks for the encouragement. I hope you get the weather and opportunity to see Comet Lulin soon. The Moon will shortly become a limiting factor, but after that, Lulin will be higher in the sky and hopefully brighter.
Posted 04 January 2009 - 04:24 PM
Not only is that an excellent sketch, you have given me a new target to look for (providing the clouds go away).
Posted 05 January 2009 - 11:06 PM
Posted 23 January 2009 - 10:17 PM
I posted a new sketch of Comet Lulin done with 2B and HB pencils and a stump and inverted.
The moon is out of the picture now so it's a good time to go comet chasing.
Posted 24 January 2009 - 02:07 AM
Another fine sketch of this morning comet. Tried to catch it the last 3 morning but all three were cloudy. Eventually I'll get a look. Thank you for posting your excellent capture here.
Posted 24 January 2009 - 06:17 AM
Thanks for the Ephemeris on Comet Lulin. It has taken me three weeks to get back to this post to catch up on responses!
I've been lost in space and so many other things lately.
Posted 24 January 2009 - 08:58 AM
Posted 25 January 2009 - 04:14 PM
I hope to observe it soon.
Posted 27 January 2009 - 02:56 PM
Thank you for your excellent observation of Comet Lulin. This is an interesting comet to follow. I hope to be able to observe it soon myself. I look forward to your future observations.
Posted 29 January 2009 - 10:04 PM
Posted 31 January 2009 - 12:52 AM
Posted 01 February 2009 - 09:56 PM
I made a new observation and sketch this morning (Feb. 1st). The sketch is here. This drawing was done indoors with HB and 2B pencils and a stump from observing notes and then inverted digitally.


text:
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Please use the menu to the right to navigate through the services offered to alumni by the CSO.


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text:
We have one user that is experiencing weird behavior when deleting messages. Sometimes when they delete a message, their view changes to a different location. It has been reported that it sometimes moves the view to a different tab (Briefcase, Tasks, etc.) and other times to a different folder within their mail.
They have no filters setup, but move all mail out of their inbox to subfolders. These folders are NOT under the inbox, but are on the same level as the Inbox, Sent, Trash, etc.
The view in mail is set to reading pane OFF, so they have to double click the message to view it. This opens the message in an additional tab within Zimbra, not in a new window.
The following behavior has been observed.
From the mail tab, a message is double-clicked. It opens in another tab. The user clicks reply. After sending the reply, they click the delete button. Most of the time this works as it should - the view is back to the folder where the message was. About every 3rd time, it changes their view to somewhere else.
Once it went to the address book. The reply button is located staggered below the Address Book tab.
The rest of the times it acts strangely, it moves the view to the Briefcase. The delete button is located staggered below the Briefcase tab.
The only browser that I can confirm this on is Firefox 24.
The only things that I can think of are possible browser/ cache issues - maybe it is not remembering the last view correctly - or possibly when clicking the button it is also clicking the tab above it. If you delete the message and it immediately goes to the Briefcase, maybe there was some overlap of the buttons.
Now if you reply and it also clicks the Address Book, maybe it takes care of the reply, then goes to the last folder it was in (Address Book, based on the overlap).


text:
first of all i have to admit, that i am a part-time admin ;-) - i'm doing these things because i have done them since 25 years in our company of 15 employees...
we run a zimbra network edition, to preserve independence of web-services - we have a huge mail-traffic with our customers and need the access to mails and attachments every time ...
not to forget the perfect management of tasks and the synchronisation with smartphones ... ;-)
i just upgraded from 7.2 to 8.0.2 and soon to 8.0.3 which were delivered the same day ...
something got wrong in my server, installed fine, configured and ran very bitchy, could not mail internally and other things, maybe the failure was made while installing 7.2 last year - got it running now, but i cannot really trust this f***ing installation ... ;-)
i'm planning a clean install!
it is a standalone server runnnig redhat enterprise 6.4 and only zimbra, i don't want the hassle of dns and records and things - so i use one of our mail-accounts of our service provider as smarthost, mails of our about 20 accounts on this web/mail-server are retrieved by pop3 - this all runs absolutely stable and fast since over 10 years now (we had a linux/squirrelmail-system until mid 2012).
so - for this configuration, i would like to do a clean install, hostname shall be "mailserver" ;-) and our domain name maybe "company.de"
file hosts contains:
file resolv.conf contains:Code:127.0.0.1 localhost.localdomain localhost 192.168.128.34 mailserver.company.de mailserver
install zimbra 8.0.3 calling the server "mailserver.company.de" or just "company.de" or maybe hostname shall be different?Code:search company.de nameserver 192.168.128.253
i had the problems of mailing internally to firstname.lastname@example.com ...
what about the mails and user configuration?
may i get them from the backups?
could someone please check this and save me from the next touchdown? ;-)


text:
that's cool EJ.. 7600 miles... I only have a little over 800 on mine.. but work is only 10 miles away.. and the speed limit is 25 to 45.. unless an SUV tries to pass me then I have these little horns that sprout out of my head... after all the first 5 letters of my last name are devil
Thanks for the reply EJ. Rolling up on 700miles here shortly and its been a dream. Yesterday though it seemed a little louder than what I've become used to. Then I noticed that I didn.t have my helmet on. But with it on, it still seemed a bit louder. Engine wise. I know that we go by "Loud valves save lives" and all, but should I be worried? Also, I did my 1st two "wrenchings" on my bike. I installed my helmet lock and adjusted the play on my front brake lever. HA! It's nothing much I know, but its not my fault my bike has given me no problems. Now having made that last statement, I'm sure that the bike will explode the next time I unlock the forks...You guys rock!
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text:
Hitachi Ultrastar A7K1000 500GB 7.2K Enterprise SATA Hard Drive 0A35770 / HUA721050KLA330 - Brand New
Capacity: 500GB
Spindle Speed: 7,200RPM
Interface Type: SATA
Disk Size: 3.5inx1.0in LFF Hard Drive
Sustained Throughput (MBps): 42-85
Average Seek Time (read/write ms): 8.5
Electrical Interface Speed: SATA 300 - 3.0Gbps
On-Board Cache: 32MB
The Ultrastar A7K1000 features a 3 Gb/s SATA interface supporting key features in the Serial-ATA specification including Native Command Queuing (NCQ), staggered spin-up and hot-swap capability. The Ultrastar A7K1000 allows for configuration scalability and with the same physical connector as Serial Attached SCSI (SAS) drives, it's ideal for use in mixed-drive environments. In multi-drive environments, rotational vibration, which results from the vibration of neighboring drives in a system, can degrade hard drive performance. To aid in maintaining high performance, the Ultrastar A7K1000 incorporates enhanced Rotational Vibration Safeguard (RVS) technology providing up to 50% improvement over the previous generation against performance degradation, leading the industry.
Hitachi p/n: 0A35770
This drive is compatible with any of our SATA drive trays as well as any system that supports SATA hard drives.
Drive specification
Formatted Gbytes (512 bytes/sector)
Bytes per sector
Read/write heads
Data Disks
Spindle speed (RPM)
Internal data transfer rate (Mbits/sec max)
I/O data transfer rate)
Cache buffer
32 Mbytes
Height (max)
26.1 mm
Width (max)
101.6 mm
Length (max)
147 mm
Weight (max) grams
Average seek, read (msec typical)
Startup current (typical) 12V (peak)
2.0 amps
Idle mode (typical) watts
Ambient temperature
5° to 60 °C (op.)
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Dell CC852 Tray and PN939 Interposer Kit
IBM 42R4129 / 42R4131 SATA/SAS Hard Drive Tray
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Hitachi Deskstar E7K1000 1000GB 7.2K SATA Hard Drives 0A38028
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text:
For the first time since a devastating tornado swept through Eastern Carolina on April 16, 2011, middle school students in Greene County get to attend a school building, rather than dozens of modular classrooms.
Teachers said it was difficult to look at the school in ruins following the 2011 storm, but they're very excited to beginning this new year.
The new school was built exactly like the old one, except stronger windows were installed and there were upgrades to the structure that will make it safer for students.
Teachers and faculty at Greene County Middle School are gearing up for a new school year in a brand new building after a tornado destroyed their school two years ago.
Gym teacher James Campbell says, "It displaced us from the building, we were forced into trailers behind our school here. The athletic fields were destroyed, the complete building was a mess."
As students get set to walk into their newer, safer building to start school this Monday, a few can't help but remember what happened back in April of 2011.
Student Conner Herring says, "They say that it should be safer, but anything can happen. Just like 2011 we weren't expecting it. We weren't wanting it to happen. I'm just glad we have a new school where we can go."
Counselors at Greene County Middle School are ready to help with the transition.
School Counselor Latolra Rodgers says, "I'm anticipating that we'll have some students come in on the first day and be a little sad, and there again as counselors we will pull them aside and pep them up, talk to them about, you know, this is going to be a great year. We have new opportunities and we're just going to own our own outcome."
Talking about natural disasters with kids can be tough, but Rodgers says the best thing to do is to prepare students with hurricane and fire drills.
The new school was built exactly like the old one, except stronger windows were installed and there were upgrades to the structure that will make it safer for students.
Classes at Greene County Middle School begin Monday.


text:
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text: Joystick's been bringin' the party since early 2002 when a group of well known, seasoned musicians from various bands got together to play the fun, energetic party songs of the 80's. They perform RETRO 80's Pop, Rock & Dance songs you grew up loving and still want to party to today! With Versatility that many of today's bands are lacking, they have kept fans around for years and years.


text:
May 25, 2016
By Alex Yoder
March 24, 2013
A severe thunderstorm watch was issued for most of the WCTV viewing area Saturday afternoon and evening.
The majority of the severe weather produced was hail. Another round of severe weather is expected with the passing of a cold front Sunday morning.
For a complete listing of severe weather reports from the National Weather Service on Saturday, click here.
By Alex Yoder
March 23, 2013
Parts of the Big Bend already got some severe weather action Saturday morning, and more is on the way.
The first round of severe weather is expected to move through the area Saturday afternoon. The main threat will be from gusty winds and hail. An isolated tornado can not be ruled out.
We'll see a break in the thunderstorm activity Saturday night. A cold front will then move through Sunday morning providing a second chance of seeing some strong to severe thunderstorms.
Keep those weather radios on and stay tuned to WCTV for the latest throughout the day. We'll always have the latest on Facebook and Twitter.
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Chemical Genetic Approach to Production of hESC-derived Cardiomyocytes
Adult heart muscle cells retain negligible proliferative capacity and this underlies the inability of the heart to replace muscle cells that are lost to injury, such as infarct, and underlies progression to heart failure. To date, no stem cell therapiy has produced significant cardiomyocyte replacement. Instead, transplanted cells, if they persist at all, produce endothelial cells or fibroblasts and the ameliorating effects on heart function that have been reported have been achieved by improving contractility, perfusion or other processes that are impaired in the failing heart. This proposal is to develop specific reagents and ultimately drugs to stimulate regeneration. Our approach integrates advances in stem cell biology, high-throughput (HT) biology, informatics and proteomics to identify small molecules, proteins and signal transduction pathways that control heart muscle formation from human embryonic stem cells (hESCs). High throughput assays will be developed and implemented to identify genes, signaling proteins, and small molecules that that control important steps in the differentiation, proliferation, and maturation of cardiac cells. Computer modeling and informatics will be used to identify and validate the signaling pathways that direct these critical processes. The discovery of small molecules and pathways will lead to protocols for 1) efficient directed differentiation of cardiomyogenic precursors from hESCs for research into transplantation and toxicology, 2) biotech reagents to stimulate cardiomyocyte renewal through directed differentiation of hESCs, and 3) cellular targets or lead compounds to develop drugs that stimulate regeneration from endogenous cells.
This proposal is a multidisciplinary collaboration among stem cell biologists, chemists, and engineers to address a critical problem that limits the widespread use of hESC for cardiology applications. Developing the multidisciplinary technology and overcoming the hurdles to application of hESCs to biotech and clinic will benefit California in many ways, including:
Research to discover novel tools to stimulate heart muscle regeneration from hESCs is clinically important. Cardiovascular disease is the single largest cause of death in the U.S. and the assays we will develop and the reagents themselves will be useful tools to direct cardiomyocyte regeneration. This will speed the translation of hESCs to the clinic, specifically by stimulating production of cardiomyocytes and potentially by enhancing their integration and function after engraftment.
Heart regeneration from hESCs probably uses similar cellular proteins and signaling pathways as regeneration of cardiomyocytes from other sources, thus, this research might be broadly applicable to heart muscle repair. Regeneration from endogenous cells remains controversial but these tools should be useful reagents to study and hopefully stimulate endogenous repair.
Bringing the diverse people together (chemists, cell biologists, and engineers) to address a stem cell problem forges new links in the academic community that should be capable of opening new areas of research. These new areas of research will be a important legacy of the stem cell initiative and promises to invigorate academic research.
The technology that we are developing applies the new discipline of chemical biology to stem cell biology, and the merger promises to spin off new areas of investigation and biotech products with the potential to benefit the practice of medicine and the local economy.
Lastly, supporting the leading edge technology and the collaboration will build the California infrastructure of high throughput chemical library screening so that it can be focused on other areas of biomedical research, both stem cell and non-stem cell.
The goal of this project is to identify small molecules that stimulate cardiomyocyte differentiation from stem cells. The strategy is to use embryonic stem ESC)-derived progenitors to screen for compounds and then optimize their chemical properties to generate molecules that can be used as reagents and potentially as lead compounds to develop drugs to stimulate regeneration in patient hearts. During year 2, progress is reported in: 1) optimizing the biological and pharmaceutical properties of 4 chemically diverse compounds discovered in year 1; 2) patent application filed on these compounds; 3) identification of targets and biological mechanism of action of 2 of the 4 compounds; 4) 1 compound has been validated in hESCs; 5) pilot screening completed of a new stem cell screen to discover molecules that act on late stage progenitors similar to cells thought to exist in the adult heart; 5) new assays developed and screened for discovering modulators of the Wnt pathway that enhance cardiomyocyte production. Thus, there are a total of 8 chemically distinct compounds under study and additional assays have been developed that should bring additional compounds into the pipeline during year 3.
This progress report covers FY3 of the project to identify and characterize novel small molecule probes of cardiomyocyte differentiation from stem cells. During FY3, we characterized 11 novel chemical entities that promote cardiomyocyte differentiation. The small, drug-like molecules affect distinct steps in cardiomyocyte differentiation – 5 compounds promote formation of uncommitted cardiac progenitors, 2 stimulated committed cardiac precursors, while 2 compounds act later to stimulate differentiation into cardiomyocytes. Thus, these compounds are novel probes of stem cell differentiation. Some of the compounds are characterized to act upon particular cellular target proteins while the targets of other compounds are unknown. Of the latter class, candidate targets have been characterized by biochemical studies; one of which has been confirmed by RNA interference, yielding a new pathway in cardiac cell formation from stem cells. Three of the chemical series have been described in a patent application. Additional primary hits are being characterized.
For FY4, we will continue characterization of a novel compounds. Particular focus will be on 4 chemical entities that promote later stages of human stem cell cardiomyocyte differentiation and on characterizing and discovering additional candidates that act on late-stage differentiation. In addition, we will develop a new pathway screen for a cellular target involved in specifying cardiomyocyte progenitors that have recently been shown to form new myocytes in vivo. Our new compounds are valuable probes of the underlying mechanism(s) responsible for making cardiac cells from stem cells. Moreover, recent data has shown that endogenous stem cells that reside in the adult heart resemble progenitors in the hESC cultures, so certain of our compounds can be considered as targeting cellular proteins and signaling pathways that might be beneficial to stimulate endogenous regeneration. Towards this goal, we will optimize the drug-like properties of the compounds in anticipation of in vivo testing for regenerative potential.
This research led to the discovery of small molecules that promote the formation of heart muscle cells from human pluripotent stem cells. The project used high throughput screening technology and medicinal chemistry, similar to that used in pharmaceutical companies, to discover and optimize the molecules. The cellular processes targeted by the compounds were also investigated, and in several cases this research uncovered novel roles for key cellular proteins and signaling pathways, such as Wnt and TGFb signaling, in stem cell differentiation. The compounds will be useful as reagents for cardiomyocyte preparation from stem cells, and patent applications have been filed.
- Nature (2014) Inhibition of miR-25 improves cardiac contractility in the failing heart. (PubMed: 24670661)
- Curr Protoc Stem Cell Biol (2012) Serum-free generation of multipotent mesoderm (kdr(+)) progenitor cells in mouse embryonic stem cells for functional genomics screening. (PubMed: 23154934)
- J Med Chem (2012) Wnt Inhibition Correlates with Human Embryonic Stem Cell Cardiomyogenesis: A Structure-Activity Relationship Study Based on Inhibitors for the Wnt Response. (PubMed: 22191557)
- Cell Stem Cell (2012) Small Molecule-Mediated TGF-beta Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells. (PubMed: 22862949)
- J Med Chem (2012) Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFbeta Signaling. (PubMed: 23130626)
- Genes Dev (2012) Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. (PubMed: 23152446)
- J Cardiovasc Transl Res (2011) A chemical biology approach to myocardial regeneration. (PubMed: 21424858)
- Circ Res (2011) Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell-Derived Mesoderm. (PubMed: 21737789)
- Mol Cell (2011) Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. (PubMed: 22099302)
- Ann N Y Acad Sci (2010) Cardiac myocyte force development during differentiation and maturation. (PubMed: 20201894)
- Proc Natl Acad Sci U S A (2010) Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. (PubMed: 20498046)
- Stem Cells Dev (2010) Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation. (PubMed: 20001453)
- PLoS One (2009) Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. (PubMed: 19352491)
- Pediatr Cardiol (2009) Natural and synthetic regulators of embryonic stem cell cardiogenesis. (PubMed: 19319460)
- PLoS Comput Biol (2009) Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors. (PubMed: 19893621)
- Circulation (2009) Electrophysiological challenges of cell-based myocardial repair. (PubMed: 20008740)
- PLoS One (2008) Contrasting expression of keratins in mouse and human embryonic stem cells. (PubMed: 18941637)
- Dev Biol (2008) A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition. (PubMed: 18840423)
- Assay Drug Dev Technol (2008) A comparative analysis of standard microtiter plate reading versus imaging in cellular assays. (PubMed: 18795873)


text: Seeking intel on oryx. My wife and I hit the lottery this year. After years of applying we have an off range hunt in June and a badge hunt in Nov. I have some experiance off-range but none on base. I am not looking for someones honey hole, just seeking any additional info anyone might be willing to share on these two hunts. Seeking any advice anyone might be willing to give. No such thing as too much intel.


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|Birds of prey set for SCORE camp
|Written by Holyoke Enterprise
|Wednesday, 20 March 2013 14:06
The public, as well as elementary students, will be host to HawkQuest and its raptors at SCORE (Science Camps Offer Rewarding Experiences) camp in Imperial, Neb. this June.
HawkQuest is a Colorado nonprofit organization that educates the public about, while interacting with, its eagles, owls, falcons and hawks at close range.
"Our message concerning the importance of biodiversity, of the finality of extinction and of man's need to nurture his world is interwoven with discussions of the raptors' place in our ecosystem," HawkQuest states.
Master falconer and long-time environmental educator Kin Quitugua founded HawkQuest in 1986. He will be bringing his program to the SCORE summer camp.
"Birds of Prey" will be offered as an outreach program, free and open to the public, Wednesday, June 12 at 5 p.m. at Chase County Schools in Imperial.
The one-hour program includes a Bald or a Golden eagle, an owl, a falcon and features a free-flying hawk.
The audience will learn about the importance of different raptor species, their specially-adapted tools and their role in our ecosystems.
"HOOT," or Hands On Owl Teaching, will be presented Thursday, June 13 to students in grades 3-4 at the Champion, Neb. Community Center.
The program brings three live owls to the students, allowing them to study the birds up close.
HOOT enables young people to understand the necessary role of the owl as predator in its natural habitat.
SCORE brochures have been distributed to each student in Chase, Dundy and Perkins counties in Nebraska. Brochures may also be picked up at area businesses or downloaded from the SCORE website at www.scorecamp.com.
Parents may also register their child online. Camps tend to fill up quickly, so early registration is suggested to secure a spot in camp.
A list of camp times and other outreach programs is found in the brochure or online.
Holyoke Enterprise March 21, 2013


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Zimbra source code was made available again as a GIT repository recently. :)
After many fixes to the current official documentation :( I have finally managed to build Zimbra OSE 8.0.6 and Zimbra OSE 8.0.7 in an Ubuntu 12.04 64 bit system :cool:. The original instructions are in Spanish but the commands speak for themselves. Just make sure you use a new minimal installation so that you don't loose any important contents.
Feel free to adapt it to a Zimbra Wiki page so that it helps more people.
Feedback is welcome.
Compilar Zimbra OSE 8.0.6
Compilar Zimbra OSE Ironmaiden (8.0.7)


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ARLINGTON, Va. (WUSA) -- Authorities are investigating what utility crews believe to be a pipe bomb, the Arlington County Police Spokesperson said.
Arlington County Police and the county's bomb squad got a call on Wednesday at about 4:30 p.m. about the suspicious find. The crew found what they describe as eight PVC pipes labeled with the word "ammunition," while digging at Carlin Springs Road and N. Kensington Street, the spokesperson said.
The spokesperson added that bomb squad is investigating the contents of the pipes.


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Morning Marketplace
This FOX Richmond Morning Marketplace segment spotlights the Richmond YMCA and their active adult programs.
Monday, October 7 2013, 02:08 PM CDT
Who's on the show?
Video List
Morning Marketplace Bio
Watch Morning Marketplace weekday mornings after FOX Richmond Morning News.. Get expert advise from the area`s top businesses and organizations and find out what`s happening in and around RVA. That`s Morning Marketplace, weekday mornings right here on FOX Richmond..


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Red Star Rising: Is U.S. Losing the Space Race?
On Sept. 29, 2011, the first module of a new space station blasted into orbit, initiating an era of space exploration different in one key respect: We didn't launch this station; China did. And while China's ascendance to space superpower confirms changes in the global economy, you shouldn't count the U.S. out of space just yet.


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Secondhand smoke isn't so bad when it's delivered by your waiter. Experimental chefs and mixologists all over the District are infusing meals and cocktails with pleasing vapors that transport patrons beyond the dining room. "Smoke makes you feel like you're outside," says Bibiana's executive chef, Nicholas Stefanelli. "It always reminds me of cooking on the grill." Whether reminiscent of the great outdoors or not, these smoky creations are a breath of fresh air.
2020 P St. NW; 202-466-4441. (Dupont Circle)
Once a month, this palace of pork hosts a bacon-centric brunch to showcase six to 10 homemade bacons, ($6 each, $14 for a flight of three, above), each made from a different pig. Chef Daniel Singhofen first rubs the hog bellies with a mixture of brown sugar, kosher salt, water and curing mix, and cold-smokes them with a combination of applewood and cherrywood for 12 hours. After taking them out and chilling them, he seals them in bags of lard before sous vide cooking them for another half day. "That's how we achieve that melt-in-your-mouth texture," Singhofen says. Finally, the bacon is sliced and fried to order.
Read about my other four smoky spots on the Express website now.


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1956 Ford F-100 - Real-World Classic TruckingWritten by on February 1, 2011 A Tribute To Our Readers And Their Rides
Tom Shaughnessy's
Tom Shaughnessy thought we'd enjoy seeing a few pics of his recently finished '56 Ford F-100. There's quite a bit of history between Tom and his F-100. He first purchased the truck in stock form years ago (1977) at the ripe old age of 14. It was powered by an inline-six backed by a three-speed trans. By '79 Tom had massaged it into road-ready condition and even treated it to a new blue paintjob. Soon after he managed to get his driver's license and both he and the pickup were ready to go. Tom drove the F-100 all through high school, but near the end finally sold it to help finance a college education. A few years later he ran across the truck and was lucky enough to buy it back. By that time it'd been modified and was equipped with a Camaro front stub and a small-block Chevy. Tom, again, drove the pickup regularly, and for the next 20 years it was his hot rod F-100. About three years ago Tom decided it was about time to go through the ol' pickup and finally upgrade it to his taste. He ended up tearing the truck down to a bare frame and proceeded to replace or rebuild everything and anything that needed it. After he was finished (he'd done it all in his home shop) he was ready for the final stage-fresh new paint and a spruced-up interior. Tom enlisted a bit of help in these respects and his fresh, new, Absolutely Red '56 hit the road again in April '10.


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Search results for 'Germany'
Nyl-Glo Germany Flag-Assorted Sizes
Starting at: $11.20100% Heavyweight SolarMax ® Nylon. Features strong duck heading and two large brass grommets. Durable and fast drying. Made to official United Nations specifications. Learn More
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Ross (et al) Null testing parabolas
Posted 07 January 2013 - 09:03 PM
So this has me thinking of building a null tester (again) and finish up work on my 20" f/4 (well, the hard part - figuring - has yet to begin).
I've read the rather long and interesting thread on Ed Jones' modified conjugate null test and just don't think that is going to work as I don't want to build the telescope 1st. So that leads me back to a Ross null tester.
Before I do, I have one nagging thing I want to make sure I understand (well, many things really :-). I had this discussion in a thread several years ago but.....
So much concern is made for very accurately measuring the "object" to lens and lens to mirror spacing. Measuring the object to lens distance very, very accurately is a piece of cake.... as you can get within several thousandths easily. So this is of no concern....
My question is why must the lens to mirror spacing be measured at all? Other than of course having a rough idea where to place your tester?
If you build a Ross Null tester that has a "stage" where by the source to lens spacing is measured and fixed; couldn't you just move that entire stage back and forth from the mirror until you get the best possible null (the object -lens spacing would NOT change)?
e.g. I would use the nifty "Ross Null Finder" software, plug in my lens data, mirror info etc... get my object to lens spacing, set that on my movable stage (as described above) and then just use a tape measure to measure my lens to mirror distance within 1/2". Then I would look across the KE or ronchi, and then precisely move the "fixed stage" back and forth until I get the best possible null. If I don't and see a raised zone etc... I would go back rework that area, then repeat.
As I understand it (which may be wrong), given a conic constant (-1 in this case) and using the object to lens spacing calculated by the software; there is only ONE conic I will null at and I can only get there when I have a parabola at the distance the software calculates.
To look at this the opposite way. For my understanding to be wrong, given that I set the object to lens distance the program tells me for a -1 conic, I can possibly achieve "false" nulls at other conics (hyperbolas etc...) by moving the "fixed" object/lens stage back and forth.... and thus end up with horrible under/over correction even though I see a perfect null through the Ross Null tester.
To make it more formulaic.... Object to lens distance (X) + Lens to mirror distance (Y) = -1 (Parabola).
If X is constant (as determined by the software), there is no Y value that will give me a null conic other than -1.
...and of course, I would be using my trusty Foucault tester as well and not rely solely on this.
Thoughts? Am I totally off base here?
Posted 08 January 2013 - 01:25 AM
Posted 08 January 2013 - 02:15 AM
You will also need some sort of leveling meachanism for the sled. My sled (above) rides on another sled which has 3 leveling screws. Both sleds use t-slots for anchoring.
As for the test itself, you must set both distances (light source-to-lens and lens-to-mirror) correctly, then (1) lock the sled, and (2) unlock the light source in order to be able to pull back and forth a little (in and out of focus) in order to observe the fringes/shadows, since the calculated distances are for the exact focal position. If you have a true paraboloid, you's see a null. Otherwise you will see bowed Ronchi bands or and k-e "doughnut" shadows.
The idea that you can just slide the sled back and forth until you see a null, and then check if the lens to mirror distance is correct is not how it works.
If things worked the way you describe it, there would indeed be no reason to measure the lens-to-mirror distance. The only way you can be certain you have a true paraboloid is if both distances are correct (within the tolerance. chosen).
One more thing: I checked the spacings necessary for a 22 inch f/4 mirror, and 1/16 wave tolerance on the mirror (1/8 on the wavefront), and for that precision both of your distances must not vary by more than ±1.2 mm (0.047 inches), which is less than 1/20". You will need a rigid radius bar and a good measuring tape (preferably in mm) for the lens to mirror separation as well.
Also, since the Ross lens has trenmendous amount of chromatic ebrration, the test must be done either with lasers or by narrow band filters. Care must be taken to interpret the final data correctly in terms of the wavelength closest to the sensitivity of the eye close to 550 nm.
In the initial stages of figuring, this may not be as crucial as it is the final stage. Thus an optical null in the red (say 632.8 nm) will not be an optical null in the green (547 nm)., as can be seen in this quality Rohr example
Posted 08 January 2013 - 06:18 AM
The colour problems are down to the wavelength the set up is designed for. I suppose it could be ray traced for blue really but red was used because dispersion of optical crown is low in that area.
I followed Texereau to the letter to start off with but found the shadows in the mask hard to read. His idea for testing a sphere for turned edge are really good. It's just a case of slit size and where the knife goes.
The Dall test had many curious artefacts in the view but eventually everything looked ok. I then went on to use a version of the Hartman test using a wire and 1in dia holes in the mask to get an accurate idea of what I had. I used a 10x loupe instead of an eyepiece. Hard to make an x-y set up at the time but with the availability of cheap Chinese lathe compound slides (top slides in the USA?) very easy to set up now.
Also tried Ronchi. Bits not available in the UK so made one by carefully winding 2 strands of fine wire and round a metal plate with a hole in it and then removing one strand. Made me wonder why people use it.
Given the quality of some of the Chines lathe parts I might use the same from Taig or Peatol in the UK. Depends on how much movement is needed.
Posted 08 January 2013 - 10:25 AM
Over at least the last five years, one or more mirrors made at our class has won an award at Stellafane in the optical judging. I'm not bragging just saying that this is an independent verification of the test methods and proceduces we use and we have many years of experience in using this test to make quality optics.
You don't need to worry about the lens to object distance, what is critical is the lens to mirror distance. When this is set you do the test just like a Foucault or Ronchi test and move the knife edge or grating inside or outside of the exact focus position to examine the figure on the mirror. I recommend using a Ronchi screen with 100 to 133 LPI. Also if you use the Ross Null program it will give you the tolerance that you need to set the this distance for mirror to lens spacing.
Don't get hung up on the tolerance of setting the spacing. What your going to find is that it is MUCH more difficult to achieve a figure that shows a perfect null then being sure that the spacing is good to a few thousands of inch. A simple radius rod made from some pine works very well. You also need to know the radii on the lens and radii of the mirror to far degree of accuracy and you need to test in monochrome light of a known wavelength. Your tester needs to have the knife edge/grating coplanar with the light source.
Once you achieve a clean null, you can double check the results using other test methods and I HIGHLY recommend that you do use other methods to check the results. What your going to find is that each method has some uncertainty associated with it, but each test method should agree with the others to within the error tolerance of the test. If they don't, you need to determine why before you can having confidence in the results.
What a null test is going to show you is exactly how difficult it is going to be to polish a true 1/8 wave wavefront on a mirror of this size and F-ratio. As I said achieving anything close to a null is were the work is going to be and not having the spacing set exactly.
All the Best,
- Dave
Posted 08 January 2013 - 10:26 AM
If things worked the way you describe it, there would indeed be no reason to measure the lens-to-mirror distance. The only way you can be certain you have a true paraboloid is if both distances are correct (within the tolerance. chosen).
One more thing: I checked the spacings necessary for a 22 inch f/4 mirror, and 1/16 wave tolerance on the mirror (1/8 on the wavefront), and for that precision both of your distances must not vary by more than ±1.2 mm (0.047 inches), which is less than 1/20". You will need a rigid radius bar and a good measuring tape (preferably in mm) for the lens to mirror separation as well.
If the object to lens distance remains fixed, can you get a "incorrect" null if you don't have the tester within the lens to mirror spacing the Ross Null program puts out?
Given a particular lens, and a particular spacing (as calculated by the Ross Null software), I thought there is only one condition where you will get a null.... 1) the surface is a parabola and 2) the spacing lens to mirror is exactly as calculated by the ross null software.
It is a 20" f/4 and as you have surmised, the lens to mirror spacing is quite tight....which is why I am concerned about it :-).
I guess what I am getting to is I am wondering what the consequences would be if I had my object to lens distance perfect but had my lens to mirror spacing off by, say, 10mm, then figured the mirror to a perfect null (if possible).
Also, BTW, I was planning to use a green LED for the source.
Posted 08 January 2013 - 10:38 AM
Steve Swayze uses the rossnull to final figure the mirror. you'll see it first hand and get experience with it.
He uses red led's.
Attached Files
Posted 08 January 2013 - 10:40 AM
I guess what I am getting to is I am wondering what the consequences would be if I had my object to lens distance perfect but had my lens to mirror spacing off by, say, 10mm, then figured the mirror to a perfect null (if possible).
Also, BTW, I was planning to use a green LED for the source. [/quote]
You don't want to set the lens to knife edge or ronchi distance. You need to be able to move the knife edge or Ronchi screen just like you do when your doing a typical Foucault test so you can see what the figure is. You set the lens to mirror distance and just do the test like your testing a spherical mirror.
If you use a green LED then your going to need to look thru a narrow band interference filter that has band pass of 10nm or less. This will define the wavelenth that your testing at and determine the spacing for that wavelength. You don't need the filter until you get close to a null, but once you get close you'll need to is sharpen up the Ronchi lines and/or improve the contrast of any faint zones you see with a knife edge.
I just use a Ronchi screen and position it so there are three lines showing and fairly quickly move it from inside to outside of focus and back again while looking for any slight bowing of the lines. When you can not detect any departure from dead straight, you have a good null.
- Dave
Posted 08 January 2013 - 11:31 AM
As you described, the lens to mirror distance is fixed precisely. This has the effect of introducing aberration such that it allows a perfect parabola to focus at a single point. Then you vary the *KE (or ronchi) to lens spacing* to see the traditional shadow movements that you see with a standard foucault test. You move the knife edge back and forth through focus and make corrections as needed to the mirror surface to achive a null. So in effect, you really don't care about the KE to lens spacing. The "corrected" focus is where it is and you must move the KE to it.
What I am wondering is, why can't we fix the KE to lens distance and vary the lens to mirror spacing (by moving this stage back and forth)? Won't this have the same effect as above?
Posted 08 January 2013 - 12:52 PM
The sled is useful for keeping everything lined up when you move the light source. Move the sled to the correct lens-to-mirror distance, then lock it in place. Then unlock the light source carriage and move where needed.
For lens-to-mirror distance use stiff radius bars with adjustable nylon tipped ends (a 1/4-20 screw is good enough). Tweak the ends to the exact distance needed and support the bar to avoid any sagging. Measure the length of the radius bar with a tape measure to the nearest mm.
Using autocllimation to check your Ross results is a good approach, but limited. At 22 inches, your mirror has pretty much exhausted that option unless you have access to a 24-inch flat. Foucault test is highly unreliable at f/4 and the Ronchi is not much more than "eyeing" the parabola - useless as far as determining the exact figure.
Your only other option is an interferometer, but again unless you have one that has a null lens built into it, such as the Zygo, you will have to depend on the Ross lens as your nulling lens, and therefore the correct lens-to-mirror distance, again, is the key factor. So, tailor your Ross test setup to meet the lens-to-mirror distance and the object-to-lens distance requirements to the "t".
Posted 08 January 2013 - 01:15 PM
You should be able to, provided you use an eyepiece which is focused on the plane of the light source, set at the correct source-to-lens distance. Then, by sliding the sled until the image of the source is in sharp focus, the lens-to mirror distance should correspond to the theoretical value within the margins of error allowed.
What I am wondering is, why can't we fix the KE to lens distance and vary the lens to mirror spacing (by moving this stage back and forth)? Won't this have the same effect as above?
Attached Files
Posted 08 January 2013 - 01:55 PM
The yahoo atm_free group is heavily into bath interferometers. They are common path and do not need expensive parts and the analysis software is free. These use a none polarising cubic beam splitter, a small mirror and a lens plus a red laser diode run below the lasing point to obtain a small source.
Making an xy stage may be expensive or a pain so I have put a microscope xy stage to one side.
This is the groups wiki
They are a friendly lot on the yahoo group but following too many questions they will say best to build one and try it. There are plenty of reports by people who have used them on the group and for what you are doing it's likely to be a sensible way to go. Me too if I finish an F2.5 mirror.
Posted 08 January 2013 - 02:06 PM
This test is not difficult to do. One huge advantage is that you see how the whole mirror is departing from the parabola you want, just like one sees how a mirror is departing from a sphere. So a hole is a hole and a hill is hill and turned edge is turned edge but instead of sphere as the reference surface they are departing from it is a parabola. Even if the spacing isn't dead perfect and you achieve a null, the result is a slightly over or undercorrected mirror but that is smooth. That is much better then a mirror that is "zoney".
As I said, you'll discover that actually getting a mirror to show a clean null is going to be the real challenge. Once you get to that point you can start to worry about getting the spacing dead on and tweeking the figure. You'll also discover that the differences from a perfect null at very slight differences of lens spacing is not easy to detect. So it is going to take some practice to detect these small differences. Again I recommend using a Ronchi screen over a knife edge and by moving the screen from inside of focus to the outside and back again fairly quickly, you can detect very small chances in the straightness of the bands.
When you think you have a perfect null, move the lens spacing by 1/8" and do the test again and see if you can detect the slight bowing of the lines. When you have trained yourself to be able to detect the difference, then you can worry about getting the exact lens to mirror spacing.
All the Best,
- Dave
Posted 08 January 2013 - 02:14 PM
You should be able to, provided you use an eyepiece which is focused on the plane of the light source, set at the correct source-to-lens distance. Then, by sliding the sled until the image of the source is in sharp focus, the lens-to mirror distance should correspond to the theoretical value within the margins of error allowed.
Why is the eyepiece needed? Guess I am missing something.... The source and the KE would be the same (slitless).
I am thinking that the same "effect" of looking across the KE with the the lens to mirror distance precisely fixed and varying the KE to lens difference would be exactly the same as fixing the source/KE to lens difference and varying the lens to mirror difference.
Guessing this is not the case? (obviously my understanding of lenses/optics is pretty limited :-) )
Posted 08 January 2013 - 06:52 PM
John, when I do the Ross test I set both distances. This way I know I am starting from the theoretical focus. To see the Ronchi bands, you have to move the source carriage a small distance until you see the bands. David G was only saying that for a Ronchi method you don't need a fixed object-lens distance, and he's right - because the Ronchi test doesn't work at the focus, but slightly in or out of the focal range.
If a knife edge can produce a null with the ross test it must be possible to set a lens to knife edge distance and then move the lot as a unit...The yahoo atm_free group is heavily into bath interferometers.... There are plenty of reports by people who have used them on the group and for what you are doing it's likely to be a sensible way to go. Me too if I finish an F2.5 mirror.
Rather than using k-e at the focus,it's much simpler to use an eyepiece at the fixed source-to-lens distance. If the eyepiece shows a sharp image (a diffraction disc) of the object, but the lens-to-mirror distance is off, then your conic is off too. When both distances are correct and the image is in sharp focus, then the conic constant is correct within the tolerance limits.
For interferometry, you need to be in focus, so the source-to-lens distance needs to be fixed in addition to the lens-to-mirror distance.
Bath interferometers are very useful and easy to construct. I use them all the time. However, a Bath will not be of much use for an f/2.5 mirror. You're better of using an autocllimator or some other null test (such as conjugate null) with such short radius of curvature.
Attached Files
Posted 08 January 2013 - 06:59 PM
For the Ronchi, test you must be inside or outside of focus. That's why you should be able to move your object source in and out of the focal position. You will immediately see if you are overcorrected, undercorrected or just right.
You can then apply the k-e and see if you get a null. If you don't have a null, the k-e test is of little value here because the TA is different than at ROC to determine how much you're off.
Posted 08 January 2013 - 07:32 PM
On the other hand if the lens is less accurately known and the mirror is known to high precision then it might make sense to do the opposite but then why would you be testing with a less qualified lens?
Posted 08 January 2013 - 09:37 PM
That's a good observation. Industrial lens standard is not that high, so are you saying that most, if not all, amateur Ross tests are done with lenses of inferior quality compared to the mirrors?
On the other hand if the lens is less accurately known and the mirror is known to high precision then it might make sense to do the opposite but then why would you be testing with a less qualified lens?
Posted 08 January 2013 - 11:07 PM
Posted 09 January 2013 - 01:49 AM
One to two percent focal length tolerance in a typical PCX lens (although it doesn't have to be PCX) used in the Ross is negligible. Try raytracing it and adjusting the bfl.
Well they have a focal length tolerane of 1 or 2 percent. Off-the-shelf lenses may not be good enough and need to be checked.
What's more important is the surface quality, but since you're typically using only the inner 30-40% of the CA, or even less in some cases, chances are your lens meets the 1/4 to 1/8 PV wave WFE, which, as DAVIDG observed, is not so easy to achieve, contrary to popular opinion, especially for big mirrors.
Perhaps if you're shooting for 1/16 wave WFE you may find yourself having to either make a better lens, or buy one for a hefty price, but surplus precision lenses, with documented data are not too expensive, and come in more than sufficient size needed for a Ross. For example SS lens PL1031 is 75 mm in diameter, fl = 185 mm, BK7, optimized at 546.1 nm (so it should be used with a correspodning NB filter), unused, and costs $8! Its data sheet number LPX 263 is from Melles Griot from which you can see the tolerances and precision, as well as other pertinenet data.
I am using a 115 mm diameter, precision positive meniscus from SS, and only its inner 35% central diameter is used.
Chances are such lenses meet the 1/4-1/16 WFE requirement within those parameters.
Posted 09 January 2013 - 02:17 AM
Dave I don't know if you replied to me (my post is referenced in your reply), but I just wanted to say you're right. The only time the lens moves is to set the lens-to-mirror distance. From there on you can do a fixed object-to-lens distance "at focus test" (k-e looking for a null, or an eypeiece test looking for a sharp image of the pinhole), or you unlock the light source stage and move the light source and the Ronchi grating in an out to assess the correction, as you said.
If the lens was moving along with the knife edge/grating, it would be varying the amount of spherical aberration and you again could find a position were it nulls but the conic is not what you want
The latter is absolutely the easiest Ross null method. With it, one can immediately see if the mirror is overcorrected or undercorrected, or "just right" (straight "jail bars").
A Ronchi null assures that the WFE is ~ 1/5 to 1/6 wave p-v, especially if using a single Ronchi bar and slowly panning it across. This by itself assures you that the mirror is good to 1/10-1/12 waves, and, in the absence of too many scratches, pits, hills, etc., a smooth mirror surface testing as an optical Null in a Ross will have an even more impressive RMS rating.
Posted 09 January 2013 - 08:14 AM
Posted 09 January 2013 - 08:45 AM
Just curious, how do you test a lens for that quality? Aren't lens requirements less stringent than for mirrors?
Most of the off-the-shelf lenses I've seen do not meet the 1/10 wave regularity requirement. Finding a good lens is one of the problems with the Ross test.
Most lenses may indeed not meet the required quality, but precision lenses, especially if large, and used only in the 1/3 inner diameter, are usually deemed adequate.
Posted 09 January 2013 - 09:20 AM
Certainly hope this is the case... the ross null tester I am about to build is using about 1/2 the lens diameter.
Just curious, how do you test a lens for that quality? Aren't lens requirements less stringent than for mirrors?
Most lenses may indeed not meet the required quality, but precision lenses, especially if large, and used only in the 1/3 inner diameter, are usually deemed adequate.
Posted 09 January 2013 - 09:34 AM
It seems to me the KE/source to lens distance is really irrelevant. The focus is where the focus is, you move the KE to it. That is, it behaves just like testing a sphere at its RoC. Now, theoretically if you have the lens to mirror spacing exactly right and you have a perfect null; then the KE to lens spacing should be what has been calculated.
Is this about right (I hope :-))?


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Playground Of The CarsWritten by on June 21, 2005 Contributors: Tim Bernsau Rods And Customs From Del MAr
Back in the days when Hollywood was all about elegance and style, the Del Mar Fairgrounds was the "playground of the stars." Famous celebrities like Bing Crosby, Betty Grable, Clark Gable, and Ava Gardner would head to this San Diego hot spot to socialize, watch the ponies run, drink martinis, and do whatever else famous celebrities did.
Today, the Del Mar Fairgrounds is still a pretty hot location, especially on the first weekend of April, when Goodguys books the place for the Del Mar Nationals and thousands of participants flood the fairgrounds with hot rods, customs, street rods, show rods, musclecars, street machines, and classic cars.
It may not be a glamorous Hollywood scene, but if you want to see style, all you have to do is hike up and down the rows of rods parked all around the grandstand and inside a few of the fairground buildings. This is Southern California's first big outdoor rod event of the season and in addition to the local iron that shows up every year, plenty of top-level rods fresh from the Grand National Roadster Show or the Detroit Autorama usually show up. Of course, Goodguys recognizes the average-joe hot rodder just as much as the big-name builder, and low-buck, homebuilt rides are just as welcome as high-end trophy cars. We saw every part of the spectrum this year, picked 10 for our R&C Top Ten awards, and photographed as many as we could. Here are a few of the rods and customs that made our cameras click (more can be found online at www.rodandcustommagazine.com).
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Would you let your daughter date a guy who drove a hot rod as tough as this flat-black, chopped, and channeled coupe? Dave Iversen owns the goose bump-giving '34, which was awarded the Memory Lane prize. The red pinstriping and those red wires are fantastic finishing touches. Have her home by midnight.Mercury only produced 2,700 S55 model Montereys in 1962 and Tom Ulrich's is still out there. He has owned it for three years, but just finished it in September, after dropping in a Lincoln 4.6L DOHC motor, reworking the entire body, and adding Air Ride 'bags and Intro wheels.Jim Austin was cruising his all-steel full-fendered '32 five-window so much we had to chase him down when traffic slowed to find out that it has a 2-inch haircut and sits on an early TCI chassis. Power comes from a ZZ4 small-block (with a single four-barrel) hooked to a TH350.PPG Mack Green and birdseye maple look perfect on Steven Early's '39 Ford DeLuxe woodie. Inside it's throwing its own beach party, with a surround-sound stereo and DVD system. A Ramjet 350 and 700-R4 get the woodie running. Chassis components include a Mustang II frontend, four-wheel disc brakes, and POSIES leafs.John Mearns has owned this Polo Green '38 Chevy for six years and transformed it from a lowrider to a custom. A Heidt's IFS was added to the original 'rails. The ZZ4 crate engine is dressed up with Moon finned valve covers and an air cleaner. The dash is filled with restored '35 Chevy truck gauges.The sweetest '40 Ford in Carpinteria is Jack Barnard's DeLuxe hardtop, built by Sam Foose. The suicide doors were stretched 7 inches and the top was chopped just right. The rear window is from a '46-'48 Ford. Check out the custom side trim, the frenched '39 headlights, and wheels painted and chromed to look like rings--an old trick.Rich Guasco's steel '32 five-window is just the right mixture of old and new. Motivation is provided by a '94 LT1 350 with factory EFI backed with an auto overdrive and Halibrand quick-change rearend. Buick drums hide behind the American Racing Slat Flat wheels. A '40 dash and wheel complement the Santana interior.
Creature comforts and high style are two things not normally associated with a Henry J, but Paul Garrett has added some of both to his '51. A Fatman IFS and Alston four-link give it a smooth ride while a Ford EFI-equipped 302 gets it rolling. The interior has been enhanced with a pair of reworked Toyota Corolla buckets and wrapped in leather.Jim Kipp's '32 roadster may look like it just rolled out of 1951, but a majority of the pieces are new. The Brookville body rests on a SO-CAL chassis that has been accessorized with some original suspension pieces. Art Chrisman built the 276ci Flathead and capped it with Edelbrock heads and an original Sling Shot intake.We're not sure if Terry Hegman's goal was to build the perfect '51 Mercury, but we do know he succeeded. The most obvious body mods are the 3-inch chop, slanted B-pillars, and smoothed nose and deck. The rest of them would take more space then we have here. Squeeg's Kustoms was responsible for the flawless deep blue finish.Choosing a theme and color for a new project isn't always easy. Being a collector of Gilmore items made the decision simple for Gary Bland when it came time for his Zipper-bodied modified. Bland built the frame and incorporated a Halibrand quick-change, Magnum 4-inch dropped I-beam, and original wide-five drums to complete the early look. A Chevy 4.3L V-6 fits nicely under the custom hood.Gold scallops and some impressive striping are part of the overall appeal of Tom Pagano's '57 Ford custom. The paint, Lancer caps, hand-fabbed grille bars, side pipes, and perfect posture all add up to a knockout ride. A '57 Thunderbird 312 resides under the hood.Man, do we like Condren Hampton's stunning '50 Merc! From the shaved sheetmetal and louvered hood, to the whitewalls, side pipes, and wicked chop (4 inches in front, 5 1/2 in back) this small-block-powered beauty is the dictionary definition of classic sledness.Richard Reed likes his tradition with a dash of luxury. He mixed marques with a Lexus engine and six-speed combo applied to his bare-metal Deuce five-window. The rest of the package--wide whites, red steelies, E&J headlights, and coolant overflow whiskey bottle--is the stuff we're used to.That sign in the windshield of Willie Dorsey's tough old gasser is a Period Perfect award announcement from Goodguys. The San Diego-based '55 Chevy, nicknamed Orange Krate, really is perfect, from the straight front axle to the rear slicks.This ground-scouring '51 Ford has been stripped of virtually all exterior trim to emphasize the body's billboard-sized slabs of sheetmetal, broken up by the louvered hood. Builder Jay Dean got a lot of attention with the metal-flaked Ford, running a 327 and 700-R4 drivetrain. Inside, it's been modified with a '59 Impala dash.
John Denich has owned this cinnamon pearl '51 Chevy for 17 years. It was flat black with a stock interior when he drove it to high school way back when, but it has looked like this since he and his dad, Jack, built it up in 1999. Engine and trans are a 350 Chevy and 700 automatic.Kevin Grani drives this red and silver on-the-ground '60 Ford Starliner, built by Andre Carey of Andre's Customs and Rods. It's powered by a Ford 352 and rolls on Billet Specialties five-spokes. Like most of Andre's customs, it manages to blend contemporary and traditional custom styles.We recognized Sammy V's '29 A from the Ranch Run. Now the well-patina'd roadster is owned by the entire Missfits car club, Angela Aglio and Lindsey Halvorson. In the month they've owned the A, they've driven it many hundreds of miles, and want to influence more women to get into hot rodding.Tim Wilson, from Long Beach, nailed the look on this much-louvered jet-black highboy, adding radial meats for roadworthiness, along with a 350 and TH350 engine and transmission combination.These old race cars were pure style. The wire wheels with lugs and knockoffs are a piece of art by themselves. CD Hall owns this '22 Deusenberg, running an all-Deusenberg drivetrain: straight 8 and three-speed. The 'rails are Nash Hudson. This car was actually raced and wrecked at Indy, ended up in Argentina, and was brought back to the U.S. eight or ten years ago.Another take on a '36 Ford is this candy burnt orange coupe, designed by father and son team Sam and Chip Foose, and owned by Ralph Weaver of Huntington Beach. The car, which features an LS1 and 4L60E, is absolutely gorgeous and was a runner-up for the Goodguys Street Rod d'Elegance award.Larry Watson's '58 T-bird is one of the most amazing recovery stories in the custom hobby. Bill Hines and Bill DeCarr at the Barris shop helped build the car when it was new, and Watson shot the world's first panel paint job. The car was torn apart in a body shop for 15 years before being rebuilt by Watson and Gary Niemie. We'll never get tired of seeing it.


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Greatest songs of the 1980s
Published On: Jun 06 2011 01:06:47 PM CDT Updated On: Feb 26 2015 01:00:00 AM CST
Here are our choices for the 50 greatest songs of the 1980s.
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Found on Smashing magazine:
Found on Smashing magazine:
great find, thanks for posting!
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I'll be checking this out, thanks for the link.
When its over and you look in the mirror, did you do the best that you were capable of? If so, the score does not matter. But if you find that you did your best you were capable of, you will find it to your liking. -John Wooden
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Am new to this forum and even to the product(Zimbra). I have zimbra opensource edition got installed and running on my Linux machine. Am going through the code to understand it and the task before me is to add chat application upon zimbra. Will be so thankful for your help & suggestions to me regarding
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I've hunted Elk in Montana a couple times but the areas I'm familiar with have been impacted by wolves pretty hard over the last 2-3 years so I'm looking and pulling info together to do a hunt in Colorado. I'm needing some input or recommendations any of you may have on a pack in service. I don't want a guided hunt but would like to get packed in and packed out of an area at a pre-determined date. This would be for a early archery hunt.
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May 25, 2016
By: Kara Duffy
February 21, 2013
Thomasville, GA- Dozens of friends and family members of 36-year-old Amy Bush-Mashburn stopped by the Morningside United Methodist Church in Thomasville Thursday evening to pick up their "Fight For Amy" t-shirts.
Friends say Mashburn, a Thomasville native, has been fighting for her life since a freak allergic reaction to a medication on Feb. 6.
She has since been transported to Emory Hospital in Atlanta.
All of the proceeds raised from t-shirt sales will help pay for Mashburn's family to travel to her.
"We just came together and decided this is what we need to do," said Fran Hood, Mashburn's friend. "We need to pull together and the whole thing has been for Amy to fight. We need the prayers and we need Amy to fight so we can bring her home."
Mashburn's friends have started a "Prayers For Amy" Facebook group.
They say over the next few weeks, they're going to continue doing special events in Amy's honor until she can finally come home,
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Mary completed the Westport Triathlon. She did the 750m sea swim, 20km cycle and a 5km run. This is the second triathlon she ever did. It was important because she turns 50 next Monday. Even though she completed all the events she was shocked to discover she had been disqualified for a wardrobe malfunction. According to appendix K rule 33 of the International Triathlon Union…..you can be disqualified for nudity or indecent exposure. Her towel slipped before she could get her bra on and she got a red card from the race steward.
Sarah logged onto the National Council for Special Education at 1130 today. This is a website that You can log onto this website to see how many SNA's are allocated to a particular school. So today, in the classroom she logged on and found out that her schools SNA allocation had been reduced from 4 to 3. She knew instantly, to her horror, that it was her job that was gone. Its last in first out. Bernard Harbour, Head of Communications at IMPACT says the panel has only just been agreed. The confusion seems to be arising from the fact that SNAs have not been given much information as yet about the situation. The impact trade union represents 6,000 SNAs.
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8 Fad-Free Basics of Weight Loss from the Experts
By Janis Jibrin, M.S., RD, Best Life lead nutritionist
Here's a secret from a nutrition insider: Even experts find weight loss fraught and confusing. A recent paper by The Obesity Society, a scientific organization devoted to researching causes and treatments for obesity, says as much. In an attempt to provide clarity, the organization published core guidelines. Not earth-shattering by any stretch, they provide an un-faddist view of the basics of weight control.
BMI is just a screening tool, not a diagnosis of 25 to 29.9 is considered "overweight" and 30-plus is "obese." If you're at 25-plus, you don't necessarily need to lose weight. But if you also have a waist circumference greater than 35 inches for women or greater than 40 inches for men, you likely do need to shed pounds.
Focus on percent of weight loss, not ideal BMI. Not everyone needs to drop below a BMI of 25 to be healthy, and some just cannot. Instead, if you have too much body fat, focus on losing at least three to five percent of your starting weight—it can significantly improve blood pressure and other aspects of your health. Losing more, like 10 percent, can be even more helpful.
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