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Palm Sunday Snow
We'll still be breezy and cool today with highs back around fifty. Easter weekend will be milder with seasonable temperatures by Easter Sunday. We had two to six inches of snow Monday but that storm pales in comparison to the 'Palm Sunday Snow Storm'. On this date in 1942 'The Big Palm Sunday Snow" hit the Metro Area. Ten to eighteen inches fell across our area. That would be a big snow in the dead of winter but imagine late March with all the plows put away for the winter. The snow fell Saturday night the 29th into the early morning hours of the 30th. This is still Downtown's biggest March snow with twelve inches, but a foot and a half fell in the northern and western suburbs. (The blizzard of '93 left six and a half inches at National.) Hagerstown recorded twenty two inches in twenty four hours. Baltimore was also buried under twenty two inches of snow ! After our winter this year a storm like that would make it a real winter. Oh well. It's hard to imagine receiving seventy five percent of our average seasonal snowfall at the end of March but I'd take it.
Records in March range from ninety three degrees to four above. March is famous for big twenty four hour temperature swings. On this date in 1921 the temperature Downtown fell from a summer-like eighty two by noon on the twenty eighth to a winter-like twenty six degrees by the early morning of the twenty ninth.


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West Side story
Special Issue | Beneath the financial frenzy that is Charlotte, urban revitalization remains long,
CHARLOTTE- In a small, yellow building near a pawn shop and a used car lot in west Charlotte, the student artwork outside a third-grade classroom at Brookstone School is revealing. Bright letters on long strips of blue, white, and green paper read: "Drugs are a bad thing to do," "Get high on God," and "Gangs kill people."
These third-graders know the realities firsthand. High concentrations of crime and poverty have plagued the West Side for years. Businesses have moved out and prostitutes have moved in. Single-parent homes dominate and public schools report dismal results: Nearly 60 percent of students in the area's major high school failed state tests last year, and the school battles escalating violence.
But the 106 inner-city kids at Brookstone, a K-6 Christian school that targets at-risk children, quietly defy those bleak statistics. Some 90 percent perform above grade level, and behavioral problems are scarce: Well-mannered children in neat uniforms sit quietly in classrooms and quickly obey teachers.
Down a short hall from Brookstone's seven classrooms, Colin Pinkney sits in his office early on a Monday morning, sorting through a long to-do list. Pinkney is the executive director of Urban Restoration, an inner-city Christian ministry that serves as an umbrella organization for several West Side ministries, including Brookstone School.
The organization's modest building sits in the shadow of Charlotte's expanding skyline, which tells the larger story of the city's dramatic growth over the last decade: a soaring, 60-story skyscraper houses the corporate headquarters of Bank of America, making the largest city in North Carolina the second-largest financial center in the country. Towering cranes dot the horizon in a profusion of development projects, including a series of high-rise condominiums that could nearly double the city's uptown population over the next three years.
But in a handful of depressed areas, a gloomier plot has unfolded, and city officials have grappled for solutions. In recent years, they've concentrated on the West Side, aiming for economic revitalization in an area that serves as a major corridor between the city's airport and uptown. Meanwhile, churches and ministries like Urban Restoration have worked with youth and families on the West Side, aiming for spiritual and social revitalization in one of the most troubled areas in town.
Leaning over a silver laptop in his small office, Pinkney says the best plan is to dovetail those efforts. To that end, Urban Restoration has cultivated relationships with local government that have produced promising results and may serve as a model for revitalization efforts in other inner-city neighborhoods.
Pinkney's savvy in working with government officials shows up in one of the first calls he makes on a Monday morning: A vacant fire station sits directly behind Urban Restoration's cramped building, and Pinkney has convinced the county to allow the ministry to use the space while it remains empty. He's following up with a contact to arrange a walk-through of the facility.
The ministry's need for more space is acute. Besides the 106-student Christian school, the small building houses administrative offices and a broad range of activities during the week: a GED prep class on Monday nights, a food pantry on Tuesday nights, parenting classes on Thursday nights, free income tax preparation for low-income families two nights a week, youth group on Friday, kids clubs on Saturday, church on Sunday, and an after-school program five days a week.
"People ask me, 'Why do you guys do so many things?'" says Pinkney. "I tell them it's because there are just so many needs."
Pinkney says the community's greatest need is stronger families, particularly stronger fathers. The county agrees and has awarded the ministry two grants to conduct family-oriented social services programs. On Thursday nights, parents gather in the center's computer lab for classes that include instruction on parenting, budgeting, and managing a household. The county requires the classes for parents seeking to be reunited with children they have lost to the system due to abuse or neglect.
A county grant also allows the ministry to recruit and provide initial screening for foster parents, and pays for an after-school program for at-risk kids called "Champions for Christ."
The grant money helps Urban Restoration stay afloat, but budgets are still tight. While preparing for a morning meeting, Pinkney breaks to make an appointment for a man who calls about the center's low-income tax preparation service. "I don't have an administrative assistant," he says, smiling, as he hangs up the phone.
At 10 a.m. Pinkney convenes a chapel service for leaders of various ministries at the center. After Bible study and prayer, the group of seven moves into the crowded conference room adjoining Pinkney's office for a lively leadership meeting. Jason Oberman gives an update on his East Side ministry to inner-city youth. "A lot of these kids can't see past the drugs and the crack in their apartment complexes," he says. "They have no hope." Oberman hopes to mentor youth who will eventually mentor other kids in the community.
Johnny Daniels enthusiastically talks about two college graduates who participated in his West Side youth program and now volunteer to help with the youth group every Friday night. "I'll take two, man," says Pinkney.
On an afternoon drive through the West Side, Pinkney points out the public-housing complexes the ministry serves. Some dilapidated units are under renovation. Others are crumbling and will soon be demolished. One whole complex has been condemned, and the families forced out. "We have no idea where these people went," says Pinkney, driving down an empty, trash-strewn street.
Families remain in run-down units, and some homeless people live in condemned houses with boarded-up windows, no electricity, and no running water, according to Pinkney. Every Saturday morning, buses from Urban Restoration roll through the neighborhoods, picking up kids for a Christian-based program at the center.
Not all public housing is in disrepair. The city recently built a new set of mixed-income townhouses, where some families on public assistance live. Repaved roads with bike paths and widened lanes have also improved the neighborhood.
Across the street sits the well-maintained Arbor Glen Recreation Center, a community center built by the county's Parks and Recreation Department. The department maintains the building and grounds but leases the center for free to Urban Restoration in exchange for the ministry's community programs, which it runs at the facility year-round.
Pinkney applauds the local government's efforts at revitalization, including a new shopping center in an intersection that was formerly notorious for drug deals. He says an improved environment is good, but he still cautions: "If you don't change the demographic, how is it going to work?"
There's one demographic Pinkney is particularly concerned about: fathers. As he drives through public-housing complexes, he says they all have one thing in common: "You won't see many men around here."
Pinkney, a father of six, is president of the PTA at his son's West Side public elementary school. He recently started a program at the school to promote the role of fathers, and more than 100 dads now attend. The superintendent of Charlotte's public-school system has asked Pinkney to replicate the program in three more West Side schools.
Pinkney is the seventh of nine children who were abandoned by their father when Pinkney was 9 years old. His father's absence wreaked havoc on his household, and that motivates Pinkney to engage other dads. "We've complicated the role of fathers in some ways," he says, "but one of the most effective things you can do is to make sure you're there."
While he's encouraged about the impact that Urban Restoration's ministry and cooperation with local government could have on the West Side, Pinkney says he constantly reminds his staff that inner-city revitalization is a long-term investment: "It's never politically correct to say that this is going to take longer than you think-but it will."

subset: commoncrawl


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Related Movies
Bedtime Stories
|Release Date: December 25, 2008
|Running Time: 99 mins.
|MPAA Rating: PG
|Box Office: $109,993,847.00
|Genre: Adventure, Comedy, Family, Fantasy
Adam Sandler
Keri Russell
Teresa Palmer
Guy Pearce
All Cast & Crew >>
Summary:Hotel handyman Skeeter Bronson's life is changed forever when the bedtime stories he tells his niece and nephew start to mysteriously come true. When he tries to help his family by telling one outlandish tale after another, it's the kids' unexpected contributions that turn all of their lives upside down.
Event Photos:


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We know there is a wealth gap, but how did it come to be? Is it natural? Inevitable?
No! The wealth gap certainly has a complicated history, but there are specific policies and practices that have contributed to its growth.
We believe the more we know about how we got here, the better we can identify ways to move forward. Based on our research of the wealth gap's history, we are releasing a series of informational sheets highlighting several factors that have increased inequality. Within each paper are the important dates, trends, and data about one instigator of the wealth gap. This information will also later made available on an interactive timeline.
The first of these papers discusses the rise of credit and household debt:
Despite increasing worker productivity, families' incomes have stagnated since the late 1970s. Credit not only masks the bottom 90%'s relative lack of wealth, it also provides a means for bankers to generate huge profits- both of which have enabled and increased the wealth gap.
To learn more, download this educational resource here. [2]
Click here to return to main Blog page [3]
Click here to check out, learn more, and join the Mind the Gap! campaign [4]


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PORTLAND, Maine (AP) - What began as a simple gesture by a wreath maker who shipped excess wreaths to Arlington National Cemetery outside Washington two decades ago continues to grow.
A convoy of trucks departs Sunday from Worcester Wreath Co. in Harrington with wreaths to be delivered to hundreds of locations. Arlington will get the most, roughly 100,000 balsam wreaths with red bows that will adorn headstones this holiday season.
It started when Morrill Worcester found himself with 5,000 wreaths that he couldn't bring to market. With the help of Sen. Olympia Snowe, he had them delivered to Arlington.
It's evolved into a broader effort called Wreaths Across America. The nonprofit says 406,000 wreaths are being shipped to more than 800 locations. A ceremony in Arlington is set for Dec. 15.


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FREDERICK COUNTY, Md. (WUSA) -- The flood warning for the Monocacy River has expired but some Frederick residents are still experiencing the effects of Superstorm Sandy.
Brunswick suffered extensive damage caused by strong winds, resulting in the city's elementary school to remain closed today due to lack of power.
Residents there are also dealing with downed trees throughout the area. 9News Scott Broom has the story.


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New York International Gift Fair
A few weekends ago in the midst of moving and planning my wedding I took a break to walk the breezy aisles of the Javits Center for the New York International Gift Fair. It was my first time at NYIGF and the amount of booths were overwhelming. I gravitated toward well designed booths and innovative products which I am happy to share below! It was a fun day exploring the immense talent hidden in the booths.
Above: The Bodega Bag. Being a native New Yorker, I think the idea of a hip accessory for a plastic bag (quite often from a bodega) is brilliant. Not only is the chain easily toted along in your purse, but it prompts folks to re-use the plastic bag. Simple, chic and green.
Below: Some of you may have already seen my tweet about Hand in Hand, which is super stylish line of soaps and bath crystals with a mission. For every bar of soap sold a bar is donated to communities that are affected by poor water quality which in term cause disease. Love them, love their mission. Anthropologie agrees.
Above: Another company on a mission, Material Good – whose Little Shirley vases stole my heart before the show, did not disappoint in person. The fact that 10% of their profit goes to organizations which support cancer research, just makes each vase a little piece of perfection.
Below: While I strolled the Handmade Global Design area of the show, Mushmina's accessories struck a cord. Their bags, jewelry, pillows and scarves were beautifully designed and unique. Mushmina notably creates employment opportunities for women and men in developing countries with their product line.
Above: Geografia is making globes hip again with their line of paper globes. Packaged flat they allow the recipient to literally put the world together. Many of the products boast cute 'core' graphics and I especially like the globes you can personalize with white board pens. Genius!
Below: Perhaps it's my love for wine or the fact that my wedding will be in wine country, but whatever the reason I fell in love with Rewined. This Charleston area company re-purposes wine bottles from local restaurants and creates soy based "wine scented" candles. Simply smart on the recycling side and super stylish on the design side with packaging that would make anyone fall in love! I might just need these for my wedding favors!All images (c) Little Maison. Please do not use without permission.


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Shows how enzymes are vital forces of any living things and uses creative and interesting examples help teach the roles of enzymes.
This lesson includes an enzyme lab, link to video, activities and homework.
A list of student-submitted discussion questions for Enzymes.
To activate prior knowledge, make personal connections, reflect on key concepts, encourage critical thinking, and assess student knowledge on the topic prior to reading using a Quickwrite.
To stress understanding of a concept by summarizing the main idea and applying that understanding to create visual aids and generate questions and comments using a Concept Matrix.
How do organisms get energy? This study guide provides an overview of energy-carrying molecules, autotrophs versus heterotrophs, the basics of chemical reactions and activation energy, and enzymes.
These flashcards help you study important terms and vocabulary from Enzymes.


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Martin Bentham began his career as a professional artist painting the subjects that were familiar to him – the landscape and people of the Mendip Hills. An ex-farm labourer, Martin's initial paintings were accurate studies reliant on expert drawing skills and choice of colour. He soon found that nature changes fleetingly when painting outdoors, colours alter according to light and weather and it was difficult to capture these changes. Oil paint, by its very nature, is a tricky medium with which to portray the subtlety of colours and texture inherent within Martin's chosen scenes.
Realising his paintings had become somewhat static led Martin to radically change his method of painting, especially the way in which he applies paint to the canvas surface. Using a palette knife to apply unmixed colours, Martin has discovered a new way to recreate natural textures such as rocks, leaves, and grass in a more expressive and exciting way. These natural characteristics are what inspires Martin to paint and his chosen medium allows him to retain the identity and characteristics of his subjects. Continuing to paint directly in front of his subject allows Martin to capture the true range of natural colours, textures and the unusual shapes that occur – so difficult to create from imagination in the studio.
Martin will be giving an exhibition tour on Saturday 6 October, 2am-3pm, providing a chance to ask questions about his artistic practice. Free with exhibition entry.
Image: Wall and Sky, Oil, 2012


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Both of my grandmothers sewed, and by this I don�t mean they could put in a hem. My paternal grandmother was a professional seamstress and crafted my mother�s wedding dress and all of her bridesmaid�s dresses. She demonstrated sewing machines in a big department store, making beautiful things while customers watched.
My mother�s mom was equally clever with a needle and thread. She made my grandfather�s suits, her family�s coats and even upholstered cars. It�s no surprise that both women came out of the Great Depression and understood the value of stretching a dollar. Back in those days, store bought clothes were expensive, so many women sewed.
And every Easter, my Grandmother Moore would make beautiful, one-of-a-kind dresses for my sister and me. They were organza and dotted Swiss, covered with lace and ruffles, and very fancy. We were the envy of all of the other moms at church.
Mom always paired these showpiece dresses with what we called �stand-out slips.� These slips had stiff skirts that made the dresses we wore over them stand out. Worn with patent leather shoes and lace-trimmed socks, we felt like little princesses on Easter, albeit itchy ones because those petticoats came with a price.
We also had coats that matched our dresses, unless it was a nice, warm spring, and best of all, Easter baskets. Being kids, the baskets full of weird fake grass, jellybeans and a big chocolate bunny were our favorite part of the day. Mom and Dad would stand us in front of our grandparents� house and take a photo of the two of us posing there, grinning, dressed in all of our Easter finery, while holding huge baskets.
But there was one thing in our Easter baskets I never quite understood: Those brightly-colored, hard, tasteless candy eggs made of some kind marshmallow product mixed with something that gave them the texture and durability of cement. Everyone raided those baskets, including our parents. But no one, not Mom, not Dad, not even other kids, wanted those brick-like, brightly colored candy eggs. Usually they were thrown out with the grass, which always made me wonder why the Easter Bunny bothered to bring them in the first place. They tasted like plaster, but as we also discovered, they also made great projectiles during the long dark sister war era.
When my kids were little, I never put those eggs in their baskets. I don�t know that I�ve even seen any since I was growing up. And if they are one of those things thoroughly relegated to the past, then there really is something from my childhood that doesn�t make me wax nostalgic in my old age � those eggs.
And Toni Home Permanents.
Carole Moore welcomes email at email@example.com.
Location, ST | website.com


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June Birthdays
Royals bench coach John Gibbons celebrated his 47th birthday on June 8. Fellow Texan and former First Lady Barbara Bush turned 84 on June 8. Nancy Sinatra, daughter of Ol' Blue Eyes and the voice behind "These Boots Are Made For Walkin'" celebrated her 69th birthday.
Royals Radio Network engineer Don Free will celebrate his birthday in multiple states on Thursday. His birthday starts in Texas as the Royals play an afternoon game in Houston. The Royals will fly to Pittsburgh Thursday evening to begin a series on Friday. Jimmie Walker, who played J.J. on "Good Times," will turn 62. As J.J would say, that's Dy-no-mite!
Shortstop Luis Hernandez will be 25 on June 26. He shares his day with another shortstop, Derek Jeter, who turns 35. Sports legend Babe Didrikson Zaharias was born on this date in 1914.
Veteran reliever Ron Mahay turns 38 on June 28. NFL Hall of Famer and 1979 Royals draft pick John Elway will be 49.
Mitch Maier rounds out the month with his 27th birthday on June 30. Fellow birthdays include Olympic swimmer Michael Phelps (24) and former heavyweight boxer Mike Tyson (43).


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Out of Stock
Item # FRS0199
Don't worry though, we have a lot more 26-inch Suspension Forks in stock than that.View Similar Products
FOX Racing Shox 32 Float 26in 100 CTD Kashima Fork $0.00
There was a time when fork tuning required an in-depth knowledge of the theories behind dampening, and Fox Racing Shox gave you complete control of every possible adjustment. This was a Boone to racers, but it quickly became clear that the general public would prefer riding over getting acquainted with the finer points of compression and rebound dampening. That's why you'll find CTD dampening on forks like this 32 Float 26in 100 CTD Kashima Fork.
Long-time Fox riders will immediately notice Fox's Climb, Trail, Descend damper adjustments. And there's no need to worry, you're still getting the same adjustments to high- and low-speed compression, only its now packaged in a more user-friendly format. Climb mode provides the most damping for a near locked-out feel. Meanwhile, it still provides a bit of cushion for any unexpected hard hits. Click the damper into the Trail mode, and you'll find that there's ample low-speed compression in order to keep the fork riding high in the travel through berms, jumps, and rocks. Better yet, it still provides plenty of compliance in order to smooth out the ride. Trail mode has three sub-settings that allow you to tune exactly how much feedback that you need from your suspension. And, as you may have guessed, Descend mode provides the lightest compression damping for a plush ride.
Depending on your tastes, many riders simply find the trail setting that works best for them, and don't feel the need to make on-the-fly adjustments. However, the CTD lever is easily accessible for those of you whose ride isn't complete until you've flipped your suspension levers a few dozen times. And best of all, those options are presented in a way that makes each adjustment instinctive. This way, you don't need a degree in fluid dynamics in order to correctly tune your suspension.
The 32 Float 100 comes with Kashima coated stanchions. And, in addition to being 100% 'gold-er' than the competition, Kashima coating is harder than standard stanchion coatings. This equates to a longer wear life, as well as smoother suspension action.
The 32 chassis is something of a classic in the Fox lineup, and it's easy to see why. With a massive tapered steerer tube, the chassis fights flex under hard braking. And speaking of stiffness, Fox uses Shimano's 15mm QR axle assembly, which provides both added stiffness and increased security over a traditional 9mm QR skewer.
The Fox Racing Shox 32 Float 26in 100 CTD Fork is available in the color Black and with a 1.5-inch tapered steerer tube. Please note that this fork is only compatible with 15QR thru-axles and 26-inch wheels.
Tech Specs
Reviews & Community
Hi, I am going to order "Fox Racing Shox...
Hi, I am going to order "Fox Racing Shox 32 Float 26in 100 CTD Kashima Fork".
Is it possible to receive the item by 26/Nov?
Shipping address is Greensboro, NC, 27409.
I plan to order on 22/Nov.
Can you recommend a head set for non-tapered...
Can you recommend a head set for non-tapered integrated head tube?
Chris King headsets are generally considered the best but pricey. Cane Creek for a middle-of-the-road and FSA as the low end. The two latter brands have some overlap with respect to quality. I would recommend Can Creek's 110 series for what you need. Make sure you fully understand what type of headset you need to fit your frame.


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Keyser, West Virginia Intellectual Property Lawyers
Michael J Eurice Esq.
Gerrardstown, WV Intellectual Property Attorney.
(304) 702-3977Pennsylvania State University - Dickinson School of Law
Mr. Cecil C. Varney Esq
Williamson, WV Intellectual Property Attorney.
(606) 237-9800Stetson University College of Law
Jeffrey V. Mehalic
Charleston, WV Intellectual Property Attorney.
The LII Lawyer Directory contains lawyers who have claimed their profiles and are actively seeking clients. Find more Keyser, West Virginia Intellectual Property Lawyers in the Justia Legal Services and Lawyers Directory which includes profiles of more than one million lawyers licensed to practice in the United States, in addition to profiles of legal aid, pro bono and legal service organizations.


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Nestled on Brooklyn's southwest coast, Bay Ridge offer some of the borough's most beautiful scenery, with views of the Verrazano Narrows Bridge, the bay and harbor, and Staten Island beyond.
(Fort Hamilton is a residential neighborhood within Bay Ridge. It's also a post of the Army National Guard and the United States Army Reserve, and these provide military support for New York City.learn more about this neighborhood
#69Neighborhood popularity:based on Naked Apartments searches
Building Mix
- 24% Pre War
- 20% Elevator/Laundry Building
- 15% Walk-Up
- 14% Private House
- 6% Condo or Co-Op Building


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We had some problems yesterday - I think we ran out of temp space until it was purged... Is it still an issue? If so -
What OS?
What version of software?
I've tested and everything looks fine to me under:
Ubuntu: Chrome, Firefox 3.x
XP: Chrome, Firefox 3.x, IE 8
Windows 7: Chrome, Firefox 3.x, IE 8
(That's all I've got to test with...)
-Rob A>


text: Ask a Question Contact the Criminal Justice Program Use the form below to submit your question to the program director. Please provide contact information and let us know the way you would prefer to receive the answer. * First Name * Last Name * Email Address Phone Number * Preferred Contact Method Please select Email or telephone Email only Telephone only My Question Enter Letters For Verification * Required Fields


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ORLANDO, Fla. (AP) --The decline in the jobless rate from 8.1 percent to 7.8 percent in September isn't forcing Mitt Romney away from his economic message.
In a fundraising message to supporters, he says the nation is "in the middle of a jobs crisis."
Romney campaigns in Florida later Saturday -- after spending part of the day preparing for his next debate with President Barack Obama.
Meanwhile, President Obama's campaign and Democrats have raised $181 million combined in September, pulling in the most money in one month during his re-election bid.
Mr. Obama's fundraising haul topped the more than $114 million raised by his campaign and Democrats during the month of August. Republican presidential nominee Mitt Romney's campaign and Republicans have not yet reported September fundraising totals.
The president says in a message on Twitter, the online social network, that more than 1.8 million people donated in September, including more than a half-million who had not donated before in 2008 or 2012.
Mr. Obama's campaign ended August with nearly $89 million in the bank. It did not release its current cash on hand.
Associated Press


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Derivation and Characterization of Myeloproliferative Disorder Stem Cells from Human ES Cells
Cancer is the leading cause of death for people younger than 85. High cancer mortality rates related to resistance to therapy and malignant progression underscore the need for more sensitive diagnostic techniques as well as therapies that selectively target cells responsible for cancer propagation. Compelling studies suggest that human cancer stem cells (CSC) arise from aberrantly self-renewing tissue specific stem or progenitor cells and are responsible for cancer propagation and resistance to therapy. Although the majority of cancer therapies eradicate rapidly dividing cells within the tumor, the rare CSC population may be quiescent and then reactivate resulting in disease progression and relapse. We recently demonstrated that CSC are generated in chronic myeloid leukemia by activation of beta-catenin, a gene that allows cells to reproduce themselves extensively. However, relatively little is known about the sequence of events responsible for leukemic transformation in more common myeloproliferative disorders (MPDs) that express an activating mutation in the JAK2 gene. Because human embryonic stem cells (hESC) have robust self-renewal capacity and can provide a potentially limitless source of tissue specific stem and progenitor cells, they represent an ideal model system for generating and characterizing human MPD stem cells. Thus, hESC cell research harbors tremendous potential for developing life-saving therapy for patients with cancer by providing a platform to rapidly and rationally test new therapies that specifically target CSC. To provide a robust model system for screening novel anti-CSC therapies, we propose to generate and characterize BCR-ABL+ and JAK2+ MPD stem cells from hESC. We will investigate the role of genes that are essential for initiation of these MPDs such as BCR-ABL and JAK2 V617F as well as additional mutations in beta-catenin or GSK3betaï€ implicated in CSC propagation. The efficacy of a selective BCR-ABL and JAK2 inhibitors at blocking BCR-ABL+ and JAK2+ human ES cell self-renewal, survival and proliferation alone and in combination with a potent and specific beta-catenin antagonist will be assessed in robust in vitro and in vivo assays with the ultimate aim of developing highly active anti-MPD stem cell therapy that may halt progression to acute leukemia and obviate therapeutic resistance.
Although much is known about the genetic and epigenetic events involved in CSC production in a Philadelphia chromosome positive MPD like chronic myeloid leukemia (CML), comparatively little is known about the molecular pathogenesis of the five-fold more common Philadelphia chromosome negative (Ph-) MPDs. MPD patients have a moderately increased risk of fatal thrombotic events as well as a striking 36-fold increased risk of death from transformation to acute leukemia. Recently, a point mutation, JAK2 V617F(JAK2+), resulting in constitutive activation of the JAK2 cytokine signaling pathway was discovered in a large proportion of MPD patients. A critical barrier to developing potentially curative therapies for both BCR-ABL+ and JAK2+ MPDs is a comprehensive understanding of relative contribution of BCR-ABL and JAK2 V617F to disease initiation versus transformation to acute leukemia. We recently discovered that JAK2 V617F is expressed at the hematopoietic stem cell level in PV, ET and MF and that JAK2 skewed ifferentiation in PV is normalized with a selective JAK2 inhibitor, TG101348. However, a detailed molecular pathogenetic characterization has been hampered by the paucity of stem and progenitor cells in MPD derived blood and marrow samples. Because hESC have robust self-renewal capacity and can provide a potentially limitless source of tissue specific stem and progenitor cells in vitro, they represent an ideal model system for generating human MPD stem cells. Thus, California hESC research harbors tremendus potential for understanding the MPD initiating events that skew differentiation versus events that promote self-renewal and thus, leukemic transformation. Moreover, a more comprehensive understanding of primitive stem cell fate decisions may yield key insights into methods to expand blood cell production that may have major implications for blood banking. Clinical Benefit Generation of MPD stem cells from hESC would provide an experimentally amenable and relevant platform to expedite the development ofsensitive diagnostic techniques to predict disease progression and to develop potentially curative anti-CSC therapies. Economic Benefit The translational research performed in the context of this grant will not only speed the delivery of innovative MPD targeted therapies for Californians, it will help to train Californiaís future R&D workforce in addition to developing leaders in translational medicine. This grant will provide the personnel working on the project with a clear view of the importance of thir research to cancer therapy and a better perspective on future career opportunities in California as well as directly generate revenue through development and implementation of innovative therapies aimed at eradicating MPD stem cells that may be more broadly applicable to CSC in other malignances.
Summary of Overall Progress
This grant focuses on generation of MPN stem cells from hESC or CB and correlates leukemic potential with MPN patient samples. In the first year of this grant, we have demonstrated that 1) hESC differentiate on AGM stroma to the CD34+ stage, which is associated with increased GATA-1, Flk2, GATA-2 and ADAR1 expression; 2) hESC CD34+ differentiation is enhanced in vitro and in vivo in the presence of a genetically engineered mouse stroma, which produces human stem cell factor, IL-3 and G-CSF; 3) hESC CD34+ cells can be transduced with our novel lentiviral BCR-ABL vector, which, unlike retroviral BCR-ABL, can transduce quiescent stem cells; 4) BCR-ABL expression by CP CML progenitors does not sustain engraftment but rather leukemic transformation is predicated, in part, on bcl-2 overexpression; 5) JAK2V617F expression in hES or CB stem cells is insufficient to induce leukemic transformation; 6) BCR-ABL transduced hESC CD34+ cells have significantly higher BCR-ABL transplantation potential than CP CML progenitors suggesting that they have higher survival capacity; 7) lentiviral -catenin transduction of BCR-ABL hESC CD34+ cells leads to serial transplantation indicative of LSC formation; 8) CML BC LSC persist in vivo despite potent BCR-ABL inhibition with dasatinib therapy and will likely require combined inhibitor therapy to eradicate. Currently, HEEBO arrays and phospho-flow studies are underway to detect bcl-2 family members and self-renewal protein expression in BCR-ABL and JAK2 V617F transduced hESC and CB CD34+ cells compared with MPN patient derived progenitors. This will aid in development of combined MPN stem cell inhibitor strategies in this grant.
This grant focuses on generation of myeloproliferative disorder or neoplasm (MPN) stem cells from pluripotent (hESC) or multipotent (CB) stem cells and seeks to correlate their leukemic potential with that of MPN patient sample-derived stem cells. To provide a platform for testing induction of stem cell differentiation, survival and self-renewal by BCR-ABL versus JAK2, hESC were utilized in the first year and as more patient samples and cord blood became available these were utilized.
In the first year of this grant, we found that hESC undergo hematopoietic differentiation on AGM stroma to the CD34+ stage resulting in increased GATA-1, Flk2, ADAR1 and GATA-2 expression. Moreover, CD34+ differentiation was enhanced on a genetically engineered mouse stroma (SL/M2) secreting human SCF, IL-3 and G-CSF. Lentiviral BCR-ABL transduced hESC-derived CD34+ cells had higher BCR-ABL+ cellular transplantation potential than chronic phase (CP) CML progenitors, indicative of a higher survival capacity. However, they sustained self-renewal only when co-transduced with lentiviral -catenin (Rusert et al, manuscript in preparation) suggesting that blast crisis evolution requires acquisition of both enhanced survival and self-renewal potential. Similarly, lentiviral mouse mutant JAK2 expression in hESC or CB stem cells was insufficient to produce self-renewing MPN stem cells, indicating that the cellular context, nature of the genetic driver and responses to extrinsic cues from the microenvironment play seminal roles in regulating therapeutically resistant MPN stem cell properties such as aberrant survival, differentiation, self-renewal and dormancy.
In the second year of this five year grant, we have focused on human cord blood (CB) stem cells compared with a large number of MPN patient samples propagated on SL/M2 stroma or in RAG2-/-c-/- mice to more adequately recapitulate the human MPN stem cell niche. Also, to more faithfully recapitulate human (rather than the previously published lentiviral mouse JAK2 vectors, Cancer Cell 2008) JAK2 driven MPNs, we cloned human wild-type JAK2 and human JAK2 V617F from MPN patient samples into lentiviral-GFP vectors (Court Recart A*, Geron I* et al, manuscript in preparation). We also incorporated full transcriptome RNA (ABI SOLiD 4.0) sequencing, PCR array and nanofluidic phosphoproteomics technology to better gauge the impact of JAK2 versus BCR-ABL on stem cell fate, survival, self-renewal and dormancy in the context of specific malignant microenvironments and the relative susceptibility of MPN stem cells in these niches to single agent molecularly targeted inhibitors.
This grant focuses on generation of myeloproliferative disorder or neoplasm (MPN) stem cells from pluripotent human embryonic stem cells (hESC) or multipotent cord blood (CB) stem cells, and seeks to correlate their leukemic potential with that of disease progression in MPN patient sample-derived stem cells. In the first and second years of this grant, we found that lentiviral BCR-ABL transduced hESC-derived CD34+ cells had higher leukemic transplantation potential than chronic phase (CP) chronic myeloid leukemia (CML) progenitors. However, they sustained self-renewal only when co-transduced with lentiviral beta-catenin suggesting that blast crisis (BC) evolution requires acquisition of both enhanced survival and self-renewal potential. Similarly, we have shown using lentiviral vectors that mouse and human mutant JAK2 were insufficient to produce self-renewing MPN stem cells. New results in Year 3 demonstrate that BCR-ABL and JAK2 activation drive differentiation of hematopoietic progenitors towards an erthyroid/myeloid lineage bias. We have used full transcriptome RNA-Sequencing (RNA-Seq) technology to evaluate the genetic and epigenetic status of BCR-ABL and JAK2-transduced normal progenitor cells as well as patient-derived MPN progenitors. This has allowed us to probe the mechanisms of aberrant differentiation and self-renewal of MPN progenitors and identify unique gene expression signatures of disease progression.
We previously found that overexpression and splice isoform switching of a key RNA editing enzyme – adenosine deaminase acting on dsRNA (ADAR), and splice isoform changes in pro-survival BCL2 family members, correspond with disease progression in CML. In the current reporting period, RNA-Seq analyses revealed that ADAR1-driven activation of RNA editing contributed to malignant progenitor reprogramming, promoting aberrant differentiation and self-renewal of MPN stem cells. Knocking down ADAR1 using lentiviral shRNA vectors reduced the self-renewal potential of CML progenitors. This work has culminated in a manuscript that has now been submitted to PNAS (Jiang et al.). Recent results also show that ADAR1 is activated in progenitors from patients with JAK2-driven MPNs. Thus, ADAR1 may be an important factor that works in concert with BCR-ABL or JAK2 to facilitate disease progression in MPNs.
Our results show that another self-renewal factor that may drive BCR-ABL or JAK2-mediated propagation of disease from quiescent MPN progenitors is Sonic hedgehog (Shh). We have examined the expression patterns of this pathway in MPN progenitors using qRT-PCR and RNA-Seq, and have tested a pharmacological inhibitor of this pathway in a robust stromal co-culture model of MPN progression to Acute Myeloid Leukemia (AML).
In sum, we have utilized full transcriptome RNA-Seq and qRT-PCR coupled with hematopoietic progenitor assays and in vivo studies to evaluate the impact of JAK2 versus BCR-ABL on stem cell fate, survival, self-renewal and dormancy. These techniques have allowed us to investigate in more detail the role of genetic and epigenetic alterations that drive disease progression in the context of specific malignant microenvironments, and the relative susceptibility of MPN stem cells in these niches to single agent molecularly targeted inhibitors.
The main objectives of this project are generation of myeloproliferative disorder or neoplasm (MPN) stem cells from pluripotent human embryonic stem cells (hESC) or multipotent stem cells, and identification of crucial leukemia stem cell (LSC) survival and self-renewal factors that contribute to the development and progression of BCR-ABL and JAK2-driven hematopoietic disorders. A key finding of our work thus far is that in addition to activation of BCR-ABL or JAK2 oncogenes, generation of self-renewing MPN LSC requires stimulation of other pro-survival and self-renewal factors such as β-catenin, Sonic hedgehog (SHH), BCL2, and in particular the RNA editing enzyme ADAR1, which we identified as a novel regulator of LSC differentiation and self-renewal.
We have now completed comprehensive gene expression analyses from next-generation RNA-sequencing studies performed on normal and leukemic human hematopoietic progenitor cells from primary cord blood samples and adult normal peripheral blood samples, along with normal cord blood transduced with BCR-ABL or JAK2 oncogenes, and primary samples from patients with BCR-ABL+ chronic phase and blast crisis chronic myeloid leukemia (CML). These studies revealed that gene expression patterns in survival and self-renewal pathways (SHH, JAK2, ADAR1) clearly distinguish normal and leukemic progenitor cells as well as MPN disease stages. These data provide a vast resource for identification of LSC-specific biomarkers with diagnostic and prognostic clinical applications, as well as providing new potential therapeutic targets to prevent disease progression.
New results from RNA-sequencing studies reveal high levels of expression of inflammatory mediators in human blast crisis CML progenitors and in BCR-ABL transduced normal cord blood stem cells. Moreover, expression of the inflammation-responsive form of ADAR1 correlated with generation of an abnormally spliced GSK3β gene product that has been previously linked to LSC self-renewal. These results have now been published in the journal PNAS (Jiang et al.). Together, we have demonstrated that ADAR1 drives hematopoietic cell fate by skewing cell differentiation – a trend which occurs during normal bone marrow aging – and promotes LSC self-renewal through alternative splicing of critical survival and self-renewal factors. Notably, inhibition of ADAR1 through genetic knockdown strategies reduced self-renewal capacity of CML LSC, and may have important applications in treatment of other disorders that transform to acute leukemia. Thus, these results suggest that RNA editing (ADAR1) and splicing represent key therapeutic targets for preventing LSC self-renewal – a primary driver of leukemic progression.
Whole transcriptome profiling studies coupled with qRT-PCR, hematopoietic progenitor assays and in vivo studies have shown that combined inhibition of BCR-ABL and JAK2 is another effective method to reduce LSC self-renewal in pre-clinical models. New results show that lentivirus-enforced BCR-ABL or JAK2 expression in normal cord blood stem cells drives generation of distinct splice isoforms of STAT5a. While inhibition of JAK2/STAT5a signaling or BCR-ABL tyrosine kinase activity alone did not eradicate self-renewing LSC, combined JAK2 and BCR-ABL inhibition dramatically impaired LSC survival and self-renewal in the protective bone marrow niche, and increased the lifespan of serial transplant recipients. These effects were associated with reduction in STAT5a isoform expression – which represents a novel molecular marker of response to combined BCR-ABL/JAK2 inhibition – and altered expression of cell cycle genes in human progenitor cells harvested from the bone marrow of transplanted mice. These results are the subject of a new manuscript currently under review (Court et al.). Moreover, this work has led to the development of new experimental tools that will facilitate study of LSC maintenance and cell cycle status in the context of normal versus diseased bone marrow microenvironments. In sum, studies completed thus far have uncovered a role for RNA editing and splicing alterations in leukemic progression, particularly in specific microenvironments. Using specific inhibitors targeting BCR-ABL and JAK2, along with strategies to block RNA editing and aberrant splicing activities, we have been able to establish the relative susceptibility of MPN stem cells to molecular inhibitors with activity against LSC residing in select hematopoietic niches that are difficult to treat with conventional chemotherapeutic agents.
In the final year of this project, we focused on elucidating the mechanisms of leukemia stem cell (LSC) generation in JAK2 compared with BCR-ABL1 initiated myeloproliferative neoplasms (MPN, previously called myeloproliferative disorders). To this end, we investigated the MPN stem cell propagating effects of BCR-ABL1 or JAK2 alone or in combination with activation of the human embryonic stem cell RNA editase, ADAR1. Recently, we discovered that ADAR1, which edits adenosine to inosine bases in the context of primate specific Alu sequences, leads to GSK3β missplicing and β-catenin activation in chronic phase (CP) CML progenitors leading to blast crisis (BC) transformation and LSC generation. In addition, variant isoform expression of a Wnt/β-catenin target gene, CD44, was also characteristic of LSC. In a previous report (Jiang et al., PNAS 2013), identification of ADAR1 as a malignant reprogramming factor represented the first description of RNA editing as a regulator of reprogramming. When lentivirally overexpressed, ADAR1 endows committed CP myeloid progenitors with self-renewal capacity. Further studies revealed that JAK2/STAT5a activates ADAR1 leading to deregulation of cell cycle progression and global down-regulation of microRNA expression thereby uncovering two additional key mechanisms of LSC generation in MPNs. This is consistent with our findings from gene expression profiling studies performed in the previous year, along with functional classification and network analysis using Ingenuity Pathway Analysis (IPA), showing that cell cycle-related genes were significantly altered in human progenitors from xenografted mice treated with combination JAK2 and BCR-ABL inhibitor therapy compared with single agent therapies alone. Together these data suggest that combined BCR-ABL and JAK2 inhibition impairs LSC survival and self-renewal via cell cycle modulation. ADAR1 and other stem cell regulatory pathways such as CD44 represent novel targets to detect and eradicate the self-renewing LSC. We also performed new studies that elucidate the stem cell-intrinsic genetic changes that occur during human bone marrow aging, which may contribute to BCR-ABL or JAK2-dependent functional alterations.
This work has led to discovery of a novel role for embryonic stem cell genes and splice isoforms, including ADAR1 p150 and a transcript variant of CD44, in the maintenance of LSC that promote MPN progression. In addition, through the course of this research we have 1) developed novel lentiviral tools for investigating normal hematopoietic stem and progenitor (HSPC) and malignant LSC survival, differentiation, self-renewal, and cell cycle regulation, and 2) devised innovative LSC diagnostic strategies and 3) tested therapeutic strategies targeting LSC-associated RNA editing and splice isoform generation that selectively inhibit LSC self-renewal.
- Proc Natl Acad Sci U S A (2012) ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. (PubMed: 23275297)
- Cancer Lett (2012) Selective elimination of leukemia stem cells: Hitting a moving target. (PubMed: 22906415)
- Curr Hematol Malig Rep (2012) Chronic myeloid leukemia stem cell biology. (PubMed: 22467334)
- PLoS One (2012) NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. (PubMed: 22768113)
- Cancer Cell (2012) Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. (PubMed: 22897851)
- Leuk Lymphoma (2012) Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. (PubMed: 23121619)
- J Clin Invest (2010) Chronic myeloid leukemia: mechanisms of blastic transformation. (PubMed: 20592475)
- Clin Cancer Res (2010) Cancer stem cells and self-renewal. (PubMed: 20530701)
- Cell (2009) CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. (PubMed: 19632178)
- Cell Stem Cell (2009) The MLLgnant consequences of reverting to an embryonic transcriptional program. (PubMed: 19200795)
- Leukemia (2009) Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues. (PubMed: 19641523)


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Hartford Hospital invites you to a free educational seminar to learn about kidney transplantation.
End stage renal disease affects thousands of Americans and is on the rise. Treatment options include dialysis and for some individuals, kidney transplantation. Learn about kidney transplant and if it may be right for you from Hartford Hospital experts Dr. Anne Lally, Coleen Smart, RN, and Paul Persaud. Together they will provide education about the kidney transplant evaluation process, surgery, living kidney donation and financial considerations.
Learning Objectives:
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L.A. Dodger Adrian Gonzalez Outfits Home with Savant and iPad Controls
Update: Baseball star Adrian Gonzalez was recently traded from the Boston Red Sox to the Los Angeles Dodgers, as part of a nine-man blockbuster deal. But the new Dodger can still peek in on his Boston-area home, thanks to a Savant control system and iPad/iPhone apps. Electronic House visited with Gonzalez and his family in their newly completed suburban Boston home that sports a game room, several surround-sound systems and an iPad-operated home control system that mirrors the interface of their residence in San Diego. Will the Gonzalezes need yet another home control system for a home in Los Angeles? That remains to be seen—but a lucky buyer in the Boston area may soon get a super-high-tech home with a very cool home control system.
It's a long way from San Diego to Boston. But when Major League Baseball star Adrian Gonzalez was traded from the San Diego Padres to the Boston Red Sox in late 2010, he knew he and his family would have to make a second home nearly 3,000 miles away.
That became a reality this April when Gonzalez, his wife Betsy and 6-month-old daughter Brianna moved into their Cape Cod-style retreat in a leafy suburb of Boston. The comfortable new digs make up for the coast-to-coast move, though, thanks in part to an Apple-based Savant control system that forms a high-tech tether to their home across the continent.
The control system in Gonzalez' Boston-area home features the same Savant system he and his family used in their San Diego home, with the same interface they've become accustomed to since 2010, when that system was first installed. "They're very familiar with it, so the learning curve is the same," says Otto Benson, president of La Jolla Home Theater & Automation in La Jolla, Calif., which equipped both of the family's bi-coastal homes with the technology.
Perhaps even better, Gonzalez and his family can use the Savant system to check in on either home remotely. "When I'm on the road I can check on the home from my iPhone and check the system and the San Diego house," he says.
iPad, iPods and iPhones
You won't find a single in-wall touchpad in Gonzelez' 9,600-square-foot East Coast residence. Nine iPads, several iPod touches and the couple's iPhones operate a host of audio/video components, as well as thermostats, the lights and security cameras.
The soft-spoken and unassuming Gonzalez leads us downstairs to the lounge, a space equipped with a 5.1-channel surround-sound system and a 55-inch Samsung HDTV flush-mounted into a stone fireplace. Paradigm speakers—the front speakers with drivers tilted 30 degrees so that the sound is aimed at the couch— are tucked into the ceiling. Gonzalez instinctively plucks an iPad from the wall. (Several of them throughout the house are mounted to Savant's in-wall docks, while others in the more media-intensive spaces are attached magnetically to the induction-charging iPort LaunchPort).
With a tap on the iPad's touchscreen, Gonzalez is quickly in the Savant app and the controls for the lounge area. He manipulates sliders to dim the lights in the room. "One of the things my wife likes is the scenes," he says, "like ALL ON and ALL OFF and PANIC!!!," where all the exterior lights flash, all house lights turn on, an alarm sounds and the police are notified.
He shows how he can swipe four fingers across the iPad's touchscreen to get from another app to the Savant app, without having to navigate to the home screen first.
Icons indicate the room lights and audio/video sources like a Squeezebox music streamer, Apple TV and Marantz Blu-ray player. He quickly calls up camera feeds from around and outside the house—a total of 14 camera views can be accessed via the iPad and other iDevices. This is one of Adrian and Betsy's favorite features.
Next, we peek into the exercise room, where instead of an iPad dock there's just a simple iPhone/iPod dock. Gonzalez can plug in his iPhone to call up his favorite country, Mexican or Christian music from the phone or via Pandora through the Logitech Squeezebox unit. His choice is delivered through the in-ceiling speakers.
Onto the game room, which features a pool table, Samsung 55-inch and 65-inch TVs, 7.1-channel surround sound with in-wall Focal speakers and a massive cherry-wood bar that is bigger than what you'd see in some barrooms.
The Focal speakers, says La Jolla Home Theater & Automation's Benson, provide good, pure audio with high fidelity, internal bass and very clear sounds. "That's something that Adrian wanted in his house," he says. The Focal speakers are used throughout for the home's 13-zone distributed audio system.
The game room, lounge and playroom upstairs run off of three Anthem 120-watt-per-channel MRX-700 A/V processors, which are stored in an equipment rack in the basement.
In his New England home, Gonzalez opted for a multiuse theater space rather than the more traditional theater he has in San Diego, which features four built-in iPad consoles in the back for multiplayer gaming. Here it's a pool table and a bar and some arcade games for kickback fun with family and friends.
Relaxing Retreat
Upstairs, the home has a comfortable and easy Cape Cod cottage feel, with hardwood floors, light-colored carpeting and soft-hued furnishings selected by interior designer Trisha Roberts, whose husband Dave Roberts also played for both the Padres and the Red Sox. It's a place most conducive to kicking back and relaxing and getting away from the outside world.
When Gonzalez gets home from a night game or a long road trip, he and Betsy usually hang out in the kitchen—equipped with Focal speakers and a 22-inch white-painted LG TV monitor that regularly displays feeds from the security cameras. They'll also plop down in the adjacent family room, with its comfortable couches, 65-inch Samsung TV and McIntosh in-ceiling speakers.
Gonzalez grabs an iPad from the iPort LaunchPort dock and quickly navigates to TV choices and the 1,400-plus movie library accessed from hard drives through a Mac mini. He likes action movies; Betsy likes chick flicks like The Notebook and Rachel McAdams films. They both like Denzel Washington and on TV they go for Animal Planet.
Benson explains that the McIntosh speakers and McIntosh MC8207 multichannel amplifier were used in the family room to provide the home's most used media space with very powerful, clear and yet warm and consuming sounds. The MC8207 sends 200 watts per channel to the five in-ceiling speakers, while Paradigm's X-300 amp delivers 300 watts to an in-wall Paradigm subwoofer.
Even 6-month-old Brianna has her own media system in a playroom upstairs, which is equipped with a 65-inch TV, 5.1-channel surround-sound system, on-wall Paradigm speakers, and a cleverly hidden Focal subwoofer. It's a room that is sure to get a lot more use as Brianna gets older. In the meantime, the family can use iPads, iPod touches and their iPhones thoughout the house to call up lullabies from Pandora to play over the Savant whole-house music system. And Brianna's bedroom has a networked camera so the family can peek in on her remotely.
Audio and video can also follow the Gonzalezes into their master suite, whether they're relaxing in the bedroom or master bath with its standalone tub and 32-inch LG TV, or reading in the sitting area that looks down to a two-story office/library, complete with its own 47-inch TV and stereo Focal speakers.
The Gonzalezes purchased the home while it was under construction, giving La Jolla Home Theater & Automation time to consult with the builder and have the house wired for audio, video and more. Dual runs of Category 6 Ethernet cabling distribute HDMI (High Definition Multimedia Interface) signals through WyreStorm HDMI baluns at either end. The house had already been wired for speakers but not for lighting. A Lutron RadioRA 2 wireless lighting control system was utilized with four RF extenders to cover the 9,500-square-foot home. It is controlled by simple wall switches—no touchpads, remember—and through the Savant app on the iDevices.
Another reason for the RadioRA 2 system: It is also used in the family's San Diego home. Familiarity here breeds confidence.
Control by Savant
Gonzalez' house may be operated exclusively by iPads, iPod touches and iPhones running Savant's control app, but behind those easy swipes of a touchscreen resides a powerful system that makes the Apple-based control seamless and instantaneous. Several Savant components reside in a basement equipment rack, giving the home the brains and the brawn to simplify the operation of a slew of audio/video equipment, lights, thermostats and security cameras.
At the core of this system:
• A Savant HST-3001 host processor and a redundant host containing the software and custom-tailored programs that run the house.
• Three SmartControl 25 units that support IR and RS-232 control, as well as triggers, relays and IP control.
• Savant System 12 modular switcher with audio and video modules to distribute audio to 13 zones and video to 11 zones.
• Two Savant AMP-1640 16-channel class D amplifiers to ensure the audio reaches its intended speakers without any degradation.
The Savant components are complemented by an Apple TV receiver, and a Mac mini hard drive. In addition, the home uses four Apple AirPort Extreme routers.
McIntosh Media Room:
In the family room, McIntosh's MC8207 amplifier delivers 200 watts to each of five McIntosh 8-inch CS100 in-ceiling speakers. Each combines an 8-inch cone woofer with a rotating baffle of a 3.5-inch midrange and 1-inch tweeter so sound is aimed directly at the listener. The A/V is tied to a McIntosh's MX121 preamp, which contains Apple AirPlay for wireless iTunes streaming.
Home Control: Savant
A/V Distribution: Savant
Lighting Control: Lutron
Video Displays: Samsung, LG
TV Mounts: Sanus
Speakers: Focal, Paradigm, McIntosh Labs
Subwoofers: Paradigm
A/V Processing: McIntosh Labs, Anthem
Amplification: McIntosh, Paradigm
Source Components: Logitech, Apple, Marantz
Security Cameras: IC Realtime
Equipment Racks: Middle Atlantic
Power Management: Monster Power
La Jolla Home Theater & Automation
La Jolla, Calif.
Trisha Roberts Design
La Jolla, Calif.
An Organized Nest
San Francisco, Calif.
Vintage Properties
Weston, Mass.
[email protected]
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When you're creating the perfect cosmetic look, every little detail matters. Lip glosses are versatile tools in any makeup collection because they are perfect for adding tiny, finishing details for both day and night. Clear formulations worn alone look clean and natural, giving you a wet, dewy look throughout your day. When slicked over a bold, bright lip color, gloss adds an extra dimension of shine to make your lips look absolutely kissable. The lightweight, long-lasting formulations found in the Stila Cosmetics Lip Gloss collection are perfect for enhancing your favorite cosmetic looks.
The Stila Cosmetics Lip Gloss line features numerous, beautiful shades from neutrals to berries to corals, allowing you to find the perfect color to suit any look. All of the products in the Stila Cosmetics Lip Gloss collection have a great taste and smooth formulations that are never sticky or difficult to apply. Many of the items in the Stila Cosmetics Lip Gloss lineup are available in mini-kits, which are great ways to get an array of complementing colors to mix and match and ideal for gift-giving.
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Morning Marketplace
This FOX Richmond Morning Marketplace segment spotlights Pool Safety with The Richmond Fire Department.
Wednesday, September 18 2013, 10:51 AM CDT
Who's on the show?
Video List
Morning Marketplace Bio
Watch Morning Marketplace weekday mornings after FOX Richmond Morning News.. Get expert advise from the area`s top businesses and organizations and find out what`s happening in and around RVA. That`s Morning Marketplace, weekday mornings right here on FOX Richmond..


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In the spirit of community collaboration and teamwork taught through youth sports, EL-MOR Chevrolet Inc. is supporting Twin Valley Soccer Club through the Chevrolet Youth Soccer Program. This sponsorship will include both monetary and equipment donations during the Fall 2012 youth soccer season.
Chevrolet Youth Soccer is a grassroots initiative that establishes a positive relationship between local dealers and the communities they serve. EL-MOR is sponsoring Twin Valley Soccer Club as a part of Chevrolet�s nation-wide commitment to support youth sports, one community at a time. Over the course of the season, EL-MOR will donate equipment to the organization which may include: soccer balls, ball bags, ball pumps, field cones, coach�s kits, corner flags, scrimmage vests, mini pop-up goals and first aid kits.
In addition, each sponsored organization will take part in the �Chevrolet Youth Soccer Breakaway Giveaway� which is a fundraiser in which each organization can raise $10,000. The �Chevrolet Youth Soccer Breakaway Giveaway� features a Grand Prize of the new 2013 Chevy Malibu, along with other great prizes such as HD Televisions, courtesy of El-MOR.
Also, thanks to EL-MOR and other participating area Chevrolet dealers, youth soccer participants will have a chance to attend a youth clinic with local professional soccer coaches.
�We are looking forward to a great season with Twin Valley Soccer Club that will be filled with exciting games and an enhanced experience for the teams through the equipment and cash donations� said EL-MOR�s Ed Skiles. �Chevrolet Youth Soccer is just one example of how committed our dealership is to supporting the youth and families in our community.�
The 2012 program will provide assistance to an impressive 314 organizations in the Northeastern region and Chevrolet dealers will contribute over $500,000 in monetary and equipment donations.
About Chevrolet- Founded in 1911 in Detroit, Chevrolet is now one of the world�s largest car brands, doing business in more than 140 countries and selling more than 4 million cars and trucks a year. Chevrolet provides customers with fuel-efficient vehicles that feature spirited performance, expressive design, and high quality. More information on Chevrolet models can be found at www.chevrolet.com.


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May 25, 2016
Associated Press Release
ST. PETERSBURG, Fla. (AP) -- A deadly algae bloom is causing a record number of manatee deaths in Florida.
That's according to a Tampa Bay Times report (http://bit.ly/VTxu36 ) that says red tide has been killing ten or more manatees a day. On Friday the number reached 149 so far this year. By the end of the weekend, that number could pass the record set in 1996 at 151 deaths.
Biologists say it's unclear if the algae bloom will let up any time soon.
Nearly a dozen manatees have been rescued and are being treated at the Lowry Park Zoo in Tampa.
Red tide turns the water into a rust color, releasing large amounts of toxins. The current bloom affects 70 miles of the southwest Florida coast, from Sarasota through the middle of Lee County.
Click Here to access the online Public Inspection File
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May 31, 2016
An upcoming murder mystery dinner theatre presentation will benefit the Meridian arts community.
"Wheel of Murder" is being presented Thursday through Saturday at 7 p.m. at the Temple Theatre ballroom, by the cast of the theatre group, Stage 2.
The whodunit centers around a game show, and the actors will interact with the audience.
"It's going to be a great show. The kids have put so much effort into this, said Kate Cherry, executive director of the Meridian Museum of Art. "They have done a great job rehearsing and they are directed by Bob Cook. He's new to the Temple Theatre and he has put on a professional presentation for the community."
Tickets are $50 each. Call the museum at 601-693-1501 for tickets.
"Wheel of Murder" is being presented through a joint partnership of the museum, Temple Theatre, Company of Angels and Stage 2.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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BEGIN:VCALENDAR VERSION:1.0 BEGIN:VEVENT DTSTART:20121204T000000 DTEND:20121204T010000 LOCATION;ENCODING=QUOTED-PRINTABLE:Thunder-Sky Inc. (4573 Hamilton Ave., Cincinnati, Ohio) DESCRIPTION;ENCODING=QUOTED-PRINTABLE:
From the 70's on into the 2000's, unconventional artist Thunder-Sky took a lot of Polaroid pictures of demolition/construction sites both here in Cincinnati and in Chicago. Thunder-Sky inc. will be showing a number of these Polaroids. A New York Times and Washington Post photo-journalist whose work often focuses on Native American issues, Pember, will be building a "wigwam" inside Thunder-Sky Inc. that will house two screens displaying photos of her mother and photos capturing the lives and struggles of contemporary Native Americans.SUMMARY;ENCODING=QUOTED-PRINTABLE:FotoFocus: Camera Shy PRIORITY:3END:VEVENT END:VCALENDAR


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George Soros Funds Free Press Thuggery (And Other Good News) [Updated]
Sorry for the goof up, folks. When I transferred this one into the browser I lost my links. The dangers of posting before bed. I've re-added them now. That's a pretty good way to describe recent actions from George Soros-paid front groups like Free Press and their band of modern day Bolsheviks. The Obama Administration's effort to expand federal "neutrality" regulation over the Internet really | Read More »


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For such a big subject, it is receiving studiously little public attention. No matter how much pharma executives eulogize the heady prospects for personalized medicine or the protean potential of pharmacogenomics, and no matter how often health authorities intone mantras about access to medicines and equality of care, everything all comes down, at the end of the day, to money. So when the European Union opens up the Pandora's box of its rules on pricing and reimbursement of drugs—the so-called "transparency directive"—you might expect a tidal wave of high-profile comment.
Yet no major debate has exploded across Europe, despite the consultation that the EU launched in March on how those rules might be tweaked to fit the 21st century. Of course, the specialized press, with its keen interest in pharma affairs, revels in exploring how the EU is going to update its 1989 requirements that member states come clean on how they make decisions on pricing and reimbursement. And of course the corridors of Brussels (and most European capital cities with a significant pharma industry presence) are hearing constant mutterings. But for all the importance of pricing and reimbursement, this remains a discreet discussion, away from the glare of TV lights and front-page headlines in the mass-circulation media. Even the usual suspects that journalists routinely turn to for a comment on new developments in European pharma policy have remained oddly silent this time around.
Why is this?Drumroll Please
One reason may well be battle fatigue. The drug industry depicts itself as (and often, these days, is) at the vortex of malevolent European forces. Certainly it has taken a battering in terms of recent pricing and reimbursement decisions in nearly every country across the continent. And the announcement of a lengthy bureaucratic consultation process on EU rules does not amount to a promise of instant salvation—particularly since the transparency directive has, it must be admitted, only a marginal on-the-ground influence on the fate of most products.
This, of course, is an obvious second reason for the apparent indifference. The ambition of the transparency directive is limited. Its essential purpose is not to guarantee that drug firms get decent prices. It was designed merely to oblige the member states to provide clarity on their national procedures and criteria, and to observe time limits for reaching decisions. So even if the directive was working well—and for the last 20 years it certainly hasn't— it would not be a determinant influence on the health of the industry. And since most of the EU's 27 member countries (nearly twice the number of members in 1989, when the legislation was adopted) frequently ignore its requirements, the chances are slim of nirvana resulting from a review of its functionality.
Another possible reason for the low-key response is that the initiative springs from the much-criticized European commissioner responsible for industry, Italy's Antonio Tajani. This man is widely perceived as overpromoted and underachieving, and many in the pharmaceutical industry are hesitant about engaging too closely in any of his projects. Those who, for good or ill, are obliged to study these things will recall that Tajani was robbed of responsibility for pharmaceuticals in the last big reshuffle of the European Commission. Ever since then he has tried to recoup some of those losses (the pharma sector is, after all, one of the jewels in the crown of European industry).
But some of his interventions have proved difficult to comprehend, even for those with years of weary experience of reading the Brussels runes. He has, for instance, embarked on a curious venture into pharmaceutical industry territory that claims simultaneously to combine corporate social responsibility with access to medicines in Europe and medical assistance to the third world. All worthy goals, no doubt, but it is no surprise that European pharmaceutical executives are keeping a cautious distance from the initiative at present. That sentiment may well be conditioning industry's response to his consultation on the transparency directive.


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Bartenders across Old North State aim to elevate mixed-drink legacy
Published: Monday, May 13, 2013 at 9:47 a.m.
Last Modified: Monday, May 13, 2013 at 9:47 a.m.
It's no great secret that superlative suds flow freely in the Old North State. With Asheville recently attempting to defend her title as Beer City USA, North Carolina bartenders aren't far behind in planting a flag for the mixed drink as a symbol of stately pride.
Manna bartender Ian Murray likes to prepare herb-infused simple syrups with a higher sugar concentration to avoid watering down drinks. He starts with a two-to-one sugar to water ratio and boils the solution for two minutes. Fresh herbs are then added and boiled for another minute. The syrup is then removed from the heat, allowed to cool and passed through a fine strainer before bottling and refrigerating. The bitters Murray uses are often homemade concoctions, but a wide range of products are commercially available.
Photo Galleries
And like the tech-savvy contemporary chefs who have embraced a hyper-local approach to running their kitchens, today's drink slinger has an ever-expanding selection of homegrown hooch to choose from.
Many of the area's ABC stores now sport sections dedicated to the state's domestic spirits, ranging from a variety of rums, gins and, naturally, several varieties of white dog (aka moonshine).
With at least a dozen distilleries producing creative libations across North Carolina, it seems a new cocktail celebrating the state debuts routinely.
Drinking local
Minus the hint of tattoo peeking out from a rolled-up shirtsleeve, Ian Murray looks every bit the vintage dandy from a century past. In a smart plaid waistcoat and spotted necktie, shaking a drink behind the stick at Manna in downtown Wilmington, the barman is on the vanguard of a wave tasked with establishing a cocktail culture celebrating the state's native spirits.
When the bashing thrum of ice against herb subsides, Murray pours his latest creation into a speakeasy-era coupe detailed with gold foil. An unforgettable air of citrus oil married to freshly muddled mint, released as he strains ice away, is every bit as intoxicating as the alcohol.
The Smoky Mountain Smash celebrates Tar Heel tradition with Covington Gourmet Sweet Potato Vodka from Snow Hill representing the state's eastern end and a strawberry-infused version of the Lenoir-based Carriage House Apple Brandy from out west. The drink is rounded out with syrup made from area-grown herbs and cinnamon nutmeg bitters Murray whips up from scratch.
"People like to hear that they're drinking something local," he said. "They can relate to the cocktail, and they get into more obscure spirits by that."
Efforts like these are earning the young mixologist accolades from peers and public alike. Murray was recently declared the victor in a cocktail competition at the Beaufort Wine & Food Weekend with a drink he dubbed the Aperteavo. Livened up with Aperol (an Italian liqueur) and cranberry bitters, the backbone of the drink is Cardinal Gin, a product out of Kings Mountain infused with Earl Gray tea. Murray has a soft spot for the gin, a spirit he holds in high regard.
"Cardinal is definitely the heaviest hitter out of all the spirits from North Carolina for me," he said. "You can sell martinis with it."
At 24, the Philadelphia transplant has dedicated himself to the bartending craft, and has found quick rapport with another of Manna's celebrated bartenders, Joel Finsel, himself a former resident of the City of Brotherly Love.
"People see how passionately we take our job. This is my career, this isn't to get me through college or something. I'll be doing this for the rest of my life," Murray said. "When you go to a bar and see somebody with passion and you can tell it's their job and they're not just cracking beers on the weekend to get by, I think that really helps. It's all about taking pride in it. People see that and they can taste it too."
That passion is fueling a creative output that's seeing the best of what North Carolina has to offer continuously redefined, and Murray is eager to put a drink in the hands of anyone curious to see for themselves.
"I'd really like for people to start opening their minds to different spirits other than Grey Goose and Dewar's and Jack Daniel's," he said. "We have such good products here and you're supporting the small guy. Why wouldn't you want to support the people like you instead of some big corporation?"
Smoky Mountains Smash
Fresh mint sprigs
2 ounces Covington Vodka
1 ounce Carriage House Strawberry-infused Apple Brandy
½ ounce lavender-and-pineapple mint syrup
½ ounce fresh lemon juice
Dash of homemade cinnamon and nutmeg bitters
In a mixing tin, add a sprig or two of mint, the syrup and lemon juice. Muddle.
Add remaining ingredients and ice. Shake for 20 seconds and strain into a coupe.
Garnish with mint and an orange peel twist.
2 ounces Trey Herring's Carolina Bourbon
1 ounce Carriage House Apple Brandy
½ ounce grade B maple syrup
½ ounce lemon juice
Dash of homemade cinnamon and nutmeg bitters
Shake ingredients in a mixing tin with ice for 20 seconds, and strain. Murray says "it tastes like Christmas in a glass."
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


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Photos: Even on game days, the work continues
The Royals and Dodgers start at 2:05 Central today. Members of the Royals were out early this morning, putting an extra emphasis on fundamentals.
Dave Owen was spotted hitting ground balls to Yuniesky Betancourt and Alberto Callaspo.
Players also spent time practicing their bunts. Here you see Rick Ankiel and Wilson Betemit getting their reps.


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Washington, DC (Sports Network) - Otto Porter Jr. scored 21 points and Markel
Starks added 16 as No. 15 Georgetown downed 18th-ranked Marquette, 63-55, at
Verizon Center.
Nate Lubick added 10 points and helped limit Marquette's two leading scorers,
Vander Blue and Davante Gardner, to nine total points.
The Hoyas (18-4, 8-3 Big East) have rattled off six consecutive wins to pull
even with Marquette for second place in the conference, a half-game behind
The Golden Eagles (17-6, 8-3) received 13 points from Jamil Wilson and 11 from
Chris Otule, but committed 19 turnovers as their two-game win streak came to
an end.
The Sports Network


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Dear friends, My Telegraph blog often used by us for sharing our personel views on politic or our own society problems and this is too normal.
But some time we shouldn't forget our globe's problems which are common problems for all of us, and we can't ignore these problems wherever we live… Of course, most of us can't be an activist in the problem zones but we can support the activists due to internet wherever we are.
And one of them is the Serengeti Highway project!..It's the greatest threat in the Serengeti's history — the government of Tanzania has approved a major commercial highway across the Serengeti National Park, in the direct path of ancient wildlife migration routes. Such a highway would be devastating.
I would like to share Dutch activist and nuture photographer, Andre Gilden's letter with you on this.
IF THE SERENGETI IS LOST – THERE WILL… Read more


text: Hi, I am trying to help out a friend using zimbra for her work email. She only works 3 days a week and would like to set up an out of office reply on the two days that she does not work which would repeat each week automatically. Does anyone know if this is possible in Zimbra? Thanks.


text: Easy storage and connection to your PC!Access your 3.5-inch Serial ATA hard drives while it's stored with this MUKii ZIPO Plus 3.5-inch SATA to SuperSpeed USB 3.0 Cable Adapter with 3.5-inch hard drive protector case! The cable adapter fits 3.5-inch Serial ATA hard drives and includes a power pass-through bracket to and connect to your PC using the SuperSpeed USB 3.0 interface for data transfers of up to 5 Gbps!The case features a secure buckle fastener and offers protection from dust, water, electrostatic discharge, and light shock. It also features a label sticker so you can keep your data organized. Get yours today!Order now!


text:
|Release Date: July 01, 2005
|Running Time: 100 mins.
|MPAA Rating: R
|Box Office: $30,291.00
|Genre: Foreign, Horror
Felicity Mason
Mungo McKay
Rob Jenkins
Lisa Cunningham
All Cast & Crew >>
Summary:Peaceful, rustic Berkeley is a charming fishing community where life is sweet and the people friendly. All that is about to change. After losing her childhood farm to the bank, local beauty Rene decides to leave town and head for the big city. Suddenly, an avalanche of meteorites races through the sky, bombarding the town and bringing an otherworldly infection. Departing is going to be much more difficult than she had planned. The living dead are reawakened and Rene is now caught in a nightmare of zombies hungry for human flesh. She manages to find salvation in a small isolated farm house owned by the town loony, Marion. There she is met with four other desperate survivors. Together they bat... Full Summary >>


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FastFloors.com is ready to lend you a hand! Our Flooring article library is your source for reliable and informative advice on selecting, purchasing, installing and caring for your floor.
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Meal Type
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food&family Magazine
32 servings or 2 loaves, 16 servings each
Read MoreRead Less
Tap or click steps to mark as complete
Bake bread as directed; cool completely. Wrap securely in plastic wrap. Freeze up to 1 month. Thaw, wrapped, at room temperature for 12 hours.
* Nutrition information is estimated based on the ingredients and cooking instructions as described in each recipe and is intended to be used for informational purposes only. Please note that nutrition details may vary based on methods of preparation, origin and freshness of ingredients used.
Loved the final product. You need your biggest mixing bowl and then go buy something bigger. the batter/dough was huge! I used three smaller store bought throw away tins to make the loaves. Very tasty and oh so moist. Hubby and I heated it up and added ice cream along with hot spiked apple cider.
Great Recipe. It came out very moist and it was even more moist after freezing and thawing a week later.
I would love it to have had more flavor though. I am going to make it again and perhaps tweak a few things.
Comes out very moist. Bread to eat now and the other to share or freeze. I sprinkled cinnamon/sugar with pecan pieces on top. And I let my batter sit for about 15 mins before I bake, (I do this as my oven may get a bit too hot when preheating, so I adjust the temp a bit lower by 25 degrees) and I believe the sitting helps in the baking where the bread comes out even and doesn't open/crack so much on top.
K:198 v0:53606


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That is all. That man needs someone to shove a sock in his mouth. Why does anyone give that nut airtime?
That is all. That man needs someone to shove a sock in his mouth. Why does anyone give that nut airtime?
Hihope Hiland Heathen of Perth CD, RE, CGC, TDI. (RIP)
Megyn Kelly set him up perfectly,the lawyer in her knew that asking him certain questions would get him into some other tangent and it came to bite him in the butt when she asked if the will of the people were against health care then why that was passed...JJ is a self anointed wanna be who no longer has any political clout or voice...his lack of credibility was exposed long ago...Now that BHO is in the WH he is struggling to stay relevant
God Bless PFC Jamie Harkness. The US Army's newest PFC, but still our neighbor's little girl!
Do not bring them down to his level, I never met a racist cabbage patch doll or DeLorean. And they both have way more credibility than him, millions of dolls sold, and the other was at least famous for traveling time...
My Father,My Friend,My teacher,and now My Angel~ 04/21/1956-03/21/2011 You will always be missed. I hope to learn half of the stuff you knew.
~Blessed are those who mourn for they shall be comforted~
His son is no better. JJ Jr. was going on and on about how the 3rd airport in IL, being built in his district, would bring so many jobs to his financially challenged district etc. until someone quietly pointed out to him that the airport is not IN his district.....
Barb Gibson
CH Rosewood Little Giant VCD2 UDX VER RA MHU SH MXP MJP MFP T2BP TD DJ VCX WCX CCA CGC FFX-OG
also UCH HR UH UUD UJJ URO1 UHIT
(golden retriever) born 3-10-07
a.k.a. "Tito", "The Tito Monster"


text:
5.8 GHz FHSS GigaRange® Supreme Handset
This item is currently not available.
Panasonic 5.8 GHz FHSS GigaRange® Supreme Expandable Digital Handset with Hearing Aid Compatibility (HAC)
- Featured
- Headsets
SpecificationsExpand All
More Details
- ***Please Note*** This model can only be used with the KX-TG5200 Series Telephone Systems
- Color Metallic Grey
- Frequency 5.8GHz
- Technology FHSS (Frequency Hopping Digital Spread Spectrum)
- Channels 89
- Skype compatible No
- ADT® Security System Compatability No
- Palmlink Communication No
- Voice Scramble Yes
- Call Waiting Caller ID Yes
- Caller ID Memory and Dialer 50
Talking Caller IDYes, if the base unit is compatible
- Caller IQ Yes, if the base unit is Caller IQ comaptible
- Phone Directory/Dialer Stations/Phonebook Memory 50
- LCD 3-Line
- Ringer Volume Control Yes
- Hold/Soft Key/Mute Yes
- Flash/Redial buttons Yes
- Talk Volume Control Yes
- Speakerphone/Spkr Volume Yes
- Intercom Yes
- Join in/Privacy/Barge in Yes
- Built-In Clock with Alarm No
- Battery Type NiMH
- Headset Jack Yes
- Answering System Yes, with compatible base unit
- AM/FM Radio with Alarm Clock on Charging Base No
- Extra Charging Cradle Yes
- Number of Phone Lines 1
- Voice Mail Message-Waiting Indicator Yes, with compatible base unit
- Navigator Key Yes
- Handset Locator Yes
- Wall Mountable Yes
- Selectable Ringtones Up to 3
- Melody Ringer Yes, 4 melodies
Ringer DownloadYes, up to 2, with compatible base unit
- Lighted Handset Keypad Yes
- Out of Range Indicator Yes
- Low Battery Indicator Yes
- Dimensions (H x W x D) 5.4'' x 3.1'' x 10.6''
- Weight 1.7 lbs
Owner's Manuals
FAQsFrequently asked questions about your product
Where can I find more support or ask questions about my product?
Click Here to visit the Panasonic Community to search for specific FAQs or tutorials for your product or ask questions directly to Panasonic or other customers.
What should I do if my product needs service?
If you have a TV, Microwave, Vacuum, or Massage Chair Click Here to locate an Authorized Servicer in your area.
For repairs and exchanges of all other products:
Ship your product to:
Panasonic Factory Service Center
4900 George McVay Drive
Suite B; Door-12
McAllen, TX 78503
Please include your name, address, telephone number, email address, copy of your purchase receipt (for warranty service), and a description of what is wrong with the unit. Freight collect shipments will not be accepted.
Panasonic is not responsible for damage that occurs in transit. All contents should be packaged for safe travel to the service center. Customer should use a reputable small package shipping company that is able to provide a package tracking number and insurance (if customer should so desire to insure their package).
Units that are abused, damaged, infested with insects, have corrosion, etc. will be placed out-of-warranty.
Once your unit arrives at the facility, you may contact us for status at:
Email: firstname.lastname@example.com
Please reference your Service Job number when contacting. You will be contacted if there is any cost you are responsible for.
How do I program or troubleshoot my telephone handset?
For proper procedures, please use you Base Unit model number as part of your search or filter as your handset is compatible to numerous models.


text:
New Orleans, LA (Sports Network) - Josh Smith stuffed the stat sheet on Tuesday, posting 23 points and 13 rebounds to go with seven assists, four blocks and three steals as the Atlanta Hawks knocked off the New Orleans Hornets, 95-86, at New Orleans Arena.
Al Horford posted 20 points on 10-of-17 shooting and Kyle Korver drained four three-pointers en route to 14 points for the Hawks, who have won five of their last six. Zaza Pachulia added 12 points and 10 boards in the victory.
Ryan Anderson hit 5-of-10 from beyond the arc and finished with a team-high 23 points, while Greivis Vasquez netted 17 points and handed out 10 assists for New Orleans, which has lost 13 of its last 15 games.
Anthony Davis ripped down 13 rebounds to go with nine points and Eric Gordon contributed 11 points in the loss.
The Sports Network


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|New irrigation techniques aid in increasing corn production
|Written by Holyoke Enterprise
The featured photo in the Enterprise 125th Anniversary calendar for the month of September is of workers in a corn field 10 miles southeast of Holyoke.
Taken in the fall of 1938, crews worked on a developing irrigation project. This particular piece of land belonged to W.E. Heginbotham, but many other landowners were also putting in systems to use flood irrigation in fields.
Contour lines were run through the fields to create ditches, followed by concrete drops and laterals. It was estimated that irrigated land would yield 60 bushels of corn per acre, compared to the average dryland yield of about 8 bushels per acre.
To read more, subscribe to our e-Edition. Call 970-854-2811.


text: classic twin If the spare parts you need are not available in Canada, you can shop within the United States region. To change your region, select United States from the drop down menu in the upper right hand corner of the screen. Please be aware that an international shipping fee will be incurred. For more information regarding shipping rates and time frames click here . 12" inner tube set includes 2 inner tubes CAD$ 19.99 12" tire set includes 2x tires CAD$ 29.99 rear wheel axle set includes 2x axles CAD$ 17.99 12" front wheel for s3, red classic, classic twin, sport strollers CAD$ 59.99 12" rear wheel CAD$ 39.99 wheel bearing set includes 6 bearings CAD$ 11.99


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BLACK FRIDAY ends tonight! Save $25 off $200* Use code: TLBF15
Buy Lorde tickets now to experience this breakout star in person! From dropping her frist EP on Sound Cloud to scoring a Grammy-nominated hit with "Royals" and a song on the Hunger Games soundtrack, Lorde is poised for super stardom. See her now before she blows up with Lorde concert tickets from Ticket Liquidator!
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Lorde released a digital album, "The Love Club EP" in March 2013 featuring five songs, including the top hit "Royals". This electro-pop track debuted at number one on New Zealand's Top 40 and remained there for three weeks. Upon its release in the United States in June 2013, over 85,000 copies were sold within one week. Other hits include "The Love Club EP" and "Tennis Court EP" which also landed a number one spot on New Zealand's Top 40 singles chart in June 2013. By the end of September 2013, her first debut album Pure Heroine was released.
Ella took on the stage name "Lorde" based on her interests in aristocracy, and attracted by the mystery of a hidden identity. Some of her musical inspiration comes from singer Etta James, rap artist Kanye West, and singer Lana Del Rey, and she is also a fan of Nicki Minaj. She has performed at the 2013 Splendour in the Grass Festival, and had a concert in her hometown of Auckland in September 2013. Check out her music with Lorde tickets, she may be near you!
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What Is Cyclone Fan Fest?
Cyclone Fan Fest is a free, interactive sports festival held in Hilton Coliseum
Save the Date!
- Aug. 23rd, 2015 from Noon to 2 p.m.
Outdoor Map
Indoor Map
Frequently Asked Questions
Where can I park?
- Parking will be in lots C3-C6 and is FREE
How much does Fan Fest cost?
- Fan Fest is a totally free event!
Is Hilton Coliseum handicap accessible?
- Yes, the handicap accessible entrances are located at the lower west doors. There is an elevator located just inside the doors, which will take you to ground level and concourse level.
How many autographs and pictures can I take with the coaches and players?
One autograph or photo allowed per person.


text:
Hey guys, really nice job with Zimbra, I can't wait to nuke my Exchange 2K3 boxes!
The only thing stopping me is my addiction to my MS Smartphone's capabilities when synching mail, contacts, calendar, etc. over the web. Activesyc is a nice little thing they got going on, especially with the current RIM patent nonsense.
Any chance Zimbra could sync over ActiveSync? Or what about Motorola's MotoSync?


text:
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You limited your search to:
Partner: UNT Libraries Government Documents Department
Serial/Series Title: 48th Legislature of Texas
Collection: Texas Senate Journals
Journal of the Senate of the State of Texas, Regular Session of the Forty-Eighth Legislature
Date: 1943
Creator: Texas. Legislature. Senate.
Description: The Journal contains the proceedings of the Senate of Texas including legislation, reports, discussions, votes, and points-of-order. Some volumes also contain supplementary materials. The index begins on page 1247.
Contributing Partner: UNT Libraries Government Documents Department


text:
[Return to Directory Listing]
Associate Professor, Mathematics
Phone: (239) 590-1262
E-Mail: email@example.com: WH 205
My primary research focus is in the field of nonparametric density estimation with application in the areas of classification & discrimination, bump hunting, and change-point analysis. I have also experience and interests in the analysis of survey data, experimental design, multivariate analysis, regression modeling, and data mining.
Florida Gulf Coast University
10501 FGCU Blvd, South
Fort Myers, FL 33965-6565
(239) 590-1000 or (800) 590-3428