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Bulletin Issues
Current Issue
Past issues of the Bulletin are available here, or through the ASIS&T Digital Library.
Bulletin, February/March 2013
Editor's Desktop
Irene L. Travis, Editor
Bulletin of the American Society for Information Science and Technology
The ASIS&T 2012 Annual Meeting the 75th anniversary meeting of the group in Baltimore is the focus of this issue. Coverage includes an expanded Inside ASIS&T, as well as a special section reporting on many of the meetings pre-conference workshops and seminars, a report on the plenary session and articles by winners of two of the Societys most prestigious awards. Our three regular columns, the Presidents Page, the IA Column and the RDAP Review also appear.
As reported in the last issue, the meeting events and attendance seem not to have taken a big hit from Sandy. As the meeting itself has been shortened in recent years, pre-conference activity has become increasingly important. Many pre-conferences are now established annual events, and some have extensive presentations, awards, associated publications and other activities. This year, the pre-conference on the history of ASIS&T and the field was particularly anticipated as it celebrated the 75th anniversary of the Society. In addition to that event, we report on pre-conferences sponsored by SIG/CR, SIG/SI and SIG/USE. We also cover the ongoing Society task force promoting the recognition of information professionals, whose activities were reported at a session on the emerging information professional.
Inside ASIS&T includes photos, coverage of 2012 award winners and extended reports on the ASIS&T Online Education and the Third ASIS&T Student Design Competition as well as the insights of Naresh Agarwal, winner of the 2012 James M. Cretsos Leadership Award, who shares his views on how new members can get more value from their ASIS&T experience and how ASIS&T might offer more value to members.
This years ASIS&T president, Andrew Dillon reports on the Presidents Page on progress toward implementing the Societys name change and on his attendance at the annual meeting of the Council of Scientific Society Presidents, in which ASIS&T, given many interests in common with other societies, might play a greater role.
Our plenary speaker this year was Edward Chang, who spoke about mobile opportunities, while Michael Buckland reflected on the purpose of information science and librarianship and the role they have played in his life in his acceptance speech for ASIS&Ts highest honor, the ASIST Award of Merit. We also asked this years Research Award honoree, Kalervo Järvelin, to tell us about his research career and findings, which he does in the article A Career in Information Retrieval.
In his IA Column Thom Haller challenges information architects to extend their work with another example of the dangers of poor design and the remedial insights offered by the principles of user affordance, while Katherine Goold Akers, this months RDAP columnist, urges librarians to pay attention to small data, which is often important and which will most likely be preserved only if local institutions undertake that responsibility.
Finally, Id like to thank the many contributors whose reports and reflections have made this issue possible.
Articles in this Issue
Third ASIS&T Student Design Competition: The "Truthiness Challenge"
ASIS&T Online Education Initiatives: Driving the Future
James Cretsos Leadership Award: What ASIS&T Means to Me
SIG/SI 8th Annual Research Symposium a Success!
The 23rd Annual SIG/CR Classification Research Workshop: A Report
The History of ASIS&T and Information Science and Technology
Evolving and Emerging Research Methods: 2012 ASIS&T SIG/USE Symposium
From Vision to Reality: The Emerging Information Professional
Edward Chang: Mobile Opportunities
Award of Merit Acceptance Speech
A Career in Information Retrieval Research
Editor's Desktop
IA: Slip-Sliding Away: Real World Challenges Await Us
RDAP Review: Looking Out For the Little Guy: Small Data Curation


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Monday News, May 14th
Fire Departments Respond to Barn Fire
(Sioux Center) -- Several fires were reported within the area over the weekend. Sioux Center, Hull, and the Maurice fire departments responded to a barn fire on Saturday evening at about 9:17 p.m. The fire was at the east edge of Sioux Center's city limits at 1768 13th Avenue South East. Although the barn was listed as a total loss, eight horses were able to be saved from the barn by residents and their friends at the farm. No report of injuries and at this time, the cause of the fire is undetermined.
Le Mars Fire Department Fights House Fire
(Le Mars) -- The Le Mars Fire Department responded to a house fire Sunday afternoon at about 2:00 p.m. The fire was located at 620 7th Avenue South East. The house is owned and occupied by Efrain Esparza and family. Upon arrival, firefighters found heavy fire on the back exterior side of the double attached garage of the home. The fire had extended into the attic of the garage and the house. Firefighters cooled the outside of the garage and house and then made entry into the attic of the garage and house. The fire was stopped in the attic area of the home and garage. The cause of the fire was determined to be from ashes and remains from a recreational fire pit that were placed in a garbage can that was next to the house. The fire pit debris rekindled and ignited material in the plastic garbage can as well as the can itself. The fire then spread to the structure. Damage is estimated at $50,000. Firefighters were on the scene for three hours.
(Le Mars) -- The Le Mars Fire Department also had to put out a field fire on Saturday evening. At about 11:00 p.m. fire officials were called to 32177 County Road C-16. When they arrived at the scene, a fence line was on fire and had burnt aproximately one-half mile. It was determined the fire started as a result of a controll burn on a tree stump that ignited the surrounding grass.
Bridge Repairs Closes C-38
(Le Mars) -- The Plymouth County Secondary Roads Department is announcing that county road C-38 from Juniper Avenue to Kestrel Avenue will be closed beginning today (Monday) and will remain closed until perhaps late October. Two bridges are being replaced on C-38. Detour will be from Highway 75 and C-38 intersection traveling south on Highway 75 to Merrill, then north from Merrill on K-42 to C-38.
School Board to Consider New Chemistry Textbook
(Le Mars) -- The Le Mars Community School Board is scheduled to meet this evening, and they will hear from Mrs. Anna Chenowith, the high school chemistry teacher. Chenowith will present her research regarding a new chemistry text book. It is expected the board will act upon Chenowith's recommendations. The local school board will act on the resignation of Kellie Bork as the 8th grade girls' assistant basketball coach, and they are expected to approve the contracts for Rachel Harris, as an elementary teacher and assistant girls' basketball coach. Randy Benton is expected to be extended a contract for teaching summer band lessons. The school board will act on the anticipated classification changes for 2012-2013. They will revise board policy and adopt revisions to the elementary student handbook, and they will review the school fees as being proposed for the upcoming 2012-2013 school year.
Life Skills To Hold Annual Meeting
(Le Mars) -- Life Skills Training Center, Incorporated will hold its annual meeting and banquet this evening at the Presbyterian United Church of Christ. Recognition of board members, foundation board members, volunteers, clients, and staff will take place. Don Nore is the executive director for Life Skills. He says tonight's festivities is to share fellowship with the families and clients.
Listen here
The Client Achievement Award will also be presented. Life Skills presently have 73 clients, and Nore says he is concerned that budget cuts may jeopardize some of the programs and services offered by Life Skills.
Listen here
Nore says one of those challenges will be the new regional system that is being proposed. The Life Skills annual meeting is scheduled to begin at 6:30 p.m.
Police Warn Citizens Not to Ride ATV's on Public Streets
(Sioux City) -- The Sioux City Police Department is reminding people that it is unlawful to operate an ATV on public roadways within the city limits. The Police is issuing the reminder following a weekend accident involving an ATV. An adult male, who's name has not been released by police officials, apparently suffered severe injuries when he was traveling eastbound on West 31st street. The operator appears to have been traveling too fast to make the turn where West 31st street turns 90 degrees onto Blair Street. The ATV slid off the roadway into an embankment. The operator was thrown from the ATV and hit a utility pole. He was not wearing a helmet. Police believe alcohol may also be a factor in the crash. The operator of the ATV was transported to a local hospital with severe head injuries.
Soderberg Favors TIF
(Le Mars) -- The use of Tax Increment Financing, or better known simply as TIF came under some scrutiny during this past legislative session. TIF has been used by communities and counties as a way to offer incentives to attract businesses. However, the reason it was under fire from some legislators is what happened in Johnson County. Coralville officials used TIF dollars to lure away businesses that were previously established in Iowa City. Le Mars state Representative Chuck Soderberg wanted to see some reform take place, but he generally favors the use of TIF dollars, saying it has benefitted several rural counties including Plymouth County.
Listen here
As chairman of the House Commerce Committee, Soderberg says the TIF reform bill was the one bill that he devoted the most of his time.
Popular Baby Names of 2011
WASHINGTON (AP) - Sophia is the new most popular baby name for girls, while Jacob is the top name for baby boys for the 13th straight year. Top baby names of 2011 Eds: With BC-US--Baby Names. By The Associated Press The top 20 baby names of 2011. --- Girls 1. Sophia 2. Isabella 3. Emma 4. Olivia 5. Ava 6. Emily 7. Abigail 8. Madison 9. Mia 10. Chloe 11. Elizabeth 12. Ella 13. Addison 14. Natalie 15. Lily 16. Grace 17. Samantha 18. Avery 19. Sofia 20. Aubrey --- Boys 1. Jacob 2. Mason 3. William 4. Jayden 5. Noah 6. Michael 7. Ethan 8. Alexander 9. Aiden 10. Daniel 11. Anthony 12. Matthew 13. Elijah 14. Joshua 15. Liam 16. Andrew 17. James 18. David 19. Benjamin 20. Logan --- Source: Social Security Administration.
The Social Security Administration released the top 1,000 baby
names of 2011 on Monday. Isabella, which had been the top girl name
for two years, dropped to second place. Emma, Olivia and Ava
rounded out the top five.
Mason jumped 10 spots to become the second most popular name for
newborn boys last year, knocking Michael out of the top five for
the first time in 63 years. Rounding out the top five boys' names:
William, Jayden and Noah.
Michael came in sixth, his lowest ranking since 1948.
WASHINGTON (AP) - Sophia is the new most popular baby name for girls, while Jacob is the top name for baby boys for the 13th straight year.
Top baby names of 2011
Eds: With BC-US--Baby Names.
By The Associated Press
The top 20 baby names of 2011.
1. Sophia
2. Isabella
3. Emma
4. Olivia
5. Ava
6. Emily
7. Abigail
8. Madison
9. Mia
10. Chloe
11. Elizabeth
12. Ella
13. Addison
14. Natalie
15. Lily
16. Grace
17. Samantha
18. Avery
19. Sofia
20. Aubrey
1. Jacob
2. Mason
3. William
4. Jayden
5. Noah
6. Michael
7. Ethan
8. Alexander
9. Aiden
10. Daniel
11. Anthony
12. Matthew
13. Elijah
14. Joshua
15. Liam
16. Andrew
17. James
18. David
19. Benjamin
20. Logan
Source: Social Security Administration.
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subset: commoncrawl


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Melbourne, Australia (Sports Network) - Sloane Stephens outlasted an injured
Serena Williams in the Australian Open quarterfinals on Wednesday to set up a
semifinal matchup with World No. 1 and defending champion Victoria Azarenka.
The 29th-seeded Sloane Stephens reached her first career major semifinal with
a 3-6, 7-5, 6-4 victory over her American compatriot, while Azarenka rolled in
the semis with a 7-5, 6-1 victory over two-time Grand Slam champion Svetlana
After Williams rolled through the first set by converting the lone break of
the frame, the players traded breaks in the second set to knot the score at
2-2, and then Stephens broke the third-seeded Williams two more times to jump
ahead 5-3.
Stephens then had a chance to serve for the set, but a double fault led to a
deuce and Williams took advantage to earn the break.
Williams, however, suffered back spasms during the game and went into the
locker room to receive treatment by medical officials.
When she returned to the court, she held serve at love to knot the set at 5-5
despite losing some velocity on her strikes, but Stephens then took advantage
of her hobbled opponent to force a third set.
Neither player could break the other in the third set until Stephens hit a
forehand into the net after a long volley to give Williams a 4-3 advantage.
But Stephens answered with a break on an unforced error by Williams on her
ensuing serve and another shot into the net by Williams put the 19-year-old
ahead, 5-4, with a chance to break for the match.
In the decisive game, Williams again struggled to get her hits over the net as
the five-time Aussie Open titlist's second unforced error of the frame
resulted in Stephens snapping Williams' 20-match win streak.
The first match of the day did not start in Azarenka's favor, as the
Belarusian fell into an early 3-1 hole in the first set after Russia's
Kuznetsova was finally able to take a 10-deuce game with her first break.
But Azarenka returned the favor with a break of her own while also holding
serve on her next two attempts to knot the score at 4-4.
Each player held serve over the next two games until Azarenka earned her
second break of the set and then fought through another tough deuce to take
the 77-minute first set.
The second set started with three straight breaks before Azarenka finally held
serve at love to jump on top 3-1.
Azarenka then closed out her dominant second set with two more breaks to
advance and keep her hopes of a repeat title alive.
The Sports Network


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Election Outlook: Will Americans Vote for Hope and P.F. Chang's?
Just a couple of months ago, DailyFinance introduced you to a new, somewhat off-the-wall, gauge of presidential-electoral success: The "Restaurant Sales" index. At the time, it showed Mitt Romney in better shape the Barack Obama. Here's what it reveals now.


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Charlotte, NC -- A judge sentenced a Charlotte man to 60 years in prison for his role in two rape cases that happened 30 years ago, according to WBTV.
Friday, A jury found Roger Dale Honeycutt, 62, guilty in connection with the 1981 rapes of two women in Charlotte.
Honeycutt was charged with two counts of second-degree rape, two counts of second-degree sex offense, and two counts of first-degree burglary. The jury convicted him of all charges.
The District Attorney's office say, on January 24, 1981, Honeycutt entered the first victim's home, covered her mouth with his hand and then raped her.
On February 21, 1981, Honeycutt came into the second victim's home and raped her while her family slept upstairs. The victim was pregnant at the time of the assault.
Honeycutt told both women he wouldn't hurt them if they didn't scream, officials said.
Charlotte-Mecklenburg Police Department's Sexual Assault Cold Case Unit connected Honeycutt to the crimes decades later when officers found that DNA evidence in the sexual assaults matched Honeycutt's DNA, which had been entered into a national database.
Officials said that because the offenses occurred in 1981, Honeycutt had to be sentenced under the Fair Sentencing Act, which preceded the current sentencing system in North Carolina that was established by the Structured Sentencing Act.
Honeycutt was sentenced to 10 to 20 years each for the second-degree rape and second-degree sex offense charges, and 10 to 30 years each for the first-degree burglary charges.


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Presents science as a group effort and covers how science information is communicated and shared.
Nobel Laureate Sir Paul Nurse discusses the importance of collaboration in the scientific community as well as the best way to implement it.
Reviews the collaborative nature of scientific research and methods of communicating information and results.
To predict the main ideas of the text based on context clues, to generate questions about a given topic and to organize and review the knowledge learned about the topic using the SQ3R strategy.
Find out why hypotheses can only be disproven and not proven.


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WHEELING - After coming up short in big games so far this season, the Shadyside girls' basketball team wanted to make sure that history wouldn't repeat itself when it came into their matchup with Wheeling Park.
Even when the team was down by as many as 15 points in the first half, the Tigers kept fighting and were able to come back and beat the Patriots, 57-45, in Wheeling on Thursday night.
"They're hard-nosed, they're gritty and they'll just keep battling and battling," Shadyside coach Tina Yates said of her team. "This is a big win. We've had a few games where we've been right there and haven't been able to overcome the hump. We started off down and just had to fight back the whole time."
Article Photos
Shadyside's Kristen Fijalkowski dribbles around the guard of Wheeling Park's Danielle Kutrovac during their game on Thursday night.
Haley Robb started the game for Park (5-3) with back-to-back 3-pointers as the Patriots raced out to a 15-2 lead midway through the first period and led 29-14 with 1:15 left in the second before the Tigers (5-5) went on a 6-0 run to close out the half.
"(Kenzie) Fielding had a big putback at the end of the first half that really sparked us going in at halftime," Yates said.
The nine-point halftime deficit gave the visitors hope as Shadyside came out determined to cut into Wheeling Park's lead.
The Tigers then used a 13-4 run to close the gap to within three at 37-34 heading into the final period.
After Fijalkowski started off the fourth with two makes from the free throw line, Hayley Holenka gained control of the ball off of a Wheeling Park turnover, raced down the court and put in a diving layup to give the Tigers their first lead of the game, 38-37.
Robb regained the lead for Park on its next possession, but it was short-lived as Karli Bonar nailed a 3-point bomb to put Shadyside ahead to stay.
"We started off a house of fire, then we lost our spark and went down hill after that," Patriots coach Dee Davis said. "We couldn't buy a basket. I don't know if they beat us or we beat us.
"Emily (Puskarich) had some nice shots that she'd hit nine out of 10 times, but it just wouldn't fall for her tonight. That happens, but there's other people on this team that needed to step up. This is a team sport."
The Robert Morris recruit finished the game with 13 points, but was held to only four in the second half.
"We wanted to know where (Puskarich) was at at all times because she's a heckuva player," Yates said. "They're a real good team and we knew coming in we would have to keep an eye on her at all times."
Robb led Wheeling Park with 16 points behind two 3s.
Holenka paced Shadyside with 22 points while Fielding ended her night with a double-double with 12 points and 11 rebounds.
Bonar and Fijalkowski each finished with 11 points apiece.
"It was a total team effort," Yates said. "They were all boxing out, went after rebounds and knocked their foul shots down. We've been working on foul shots. They get in that mind frame that they're going to go in, and we've been making them. I just hope we keep making them."


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See All Contributors »
What all are we going to hear and see?
Originally Posted by BoxsterCy
Dude, you are Gameday Rulzzz and could probably post about anything.
I am hoping for a wardrobe malfunction.
"Don't look back. Something might be gaining on you."
-Satchel Paige
Just like every year, a terrible show where one performer will do something that gets everyone all fired up and it's all over the news for a few a weeks.
******* beat me to this thread!
i need the credits
Originally Posted by mac4cy
I am hoping for a wardrobe malfunction.
on jay z im guessing?
Originally Posted by TallKidIsTall
******* beat me to this thread!
i need the credits
got to be quicker man. :)
Destiny Child Reunion
Come on Beyonce keep stripping :)
What's with the tranny playing guitar?
Favorite posters: I hate you all
does she plan on singing at all?
or just dancing to the background voices
And least there will be no lip syncing controversy. She's not even pretending to sing.
Kelly Rowland > Beyonce.
Bringing out the rest of Destiny's Child is supposed to make this better?
"That's what I do. I drink, and I know things." - Tyrion Lannister
"Success is just failure that hasn't happened yet." - life advice from Latrell Spreewell
She can't sing live. Just acting like she can.
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LAS CRUCES, N.M. (AP) — Suddenly they seem to be showing up everywhere.
Dapper, carefully-trimmed moustaches on businessmen. Freestyle versions on college students, sometimes punctuated with soul patches.
Elaborately-groomed handlebars on cowpokes and bartenders. More pronounced versions on previously discreetly airbrushed images of Frida Kahlo. Big black moustaches on babies ...
Moustaches are trending so strongly that the hirsute fashion statement is boldly going where it's never gone before. On infants' pacifiers, for instance. And on temporary tattoos. Apply one to your index finger, and with a quick gesture, you can join the ranks of the mustachioed any time.
Richard Parra, owner of Spirit Winds in Las Cruces, says he can't keep the moustache paraphernalia in stock.
"We're sold out of the pacifiers. People think they're really funny. All our moustache accoutrements have been selling fast for more than a year.
Right now, we've got some moustache earrings, corkscrews and bumper stickers," said Parra, who is growing a moustache himself.
"It's actually part of a goatee. I just started. It's part of my new winter look," he quipped.
These days, Matt Bleything, owner of LuLu's in Mesilla, may also be paying more attention to mustaches than an old time barber.
The moustache section of his trendy boutique includes everything from baby binkies and moustache-shaped paper clips to a silver moustache ring and temporary tattoos. Apply one to your index finger (or the double Fingerstache to two fingers) and you can quickly assume your choice of 19 personas: Oilman, Carnies, Neighborino, Gunslinger, Professor, Dandy, Plumber, El Bandito, Crybaby, Prospector, Makeout Bandit, Magnum, Sheriff, Villain, 8th Grade Bully, Swashbuckler, Pushbroom or Rich Uncle.
A six-pack of stick-on famous artists' moustaches ranges from a salt-and-pepper Rembrandt to a fiery red Vincent van Gogh.
In fact, some moustaches are so famous that no images are necessary: a name will suffice to conjure the 'stache style. Consider the list of "Top 10 Most Famous Moustaches" on TopTenz.net: Fu Manchu, Tom Selleck, Adolf Hitler, Groucho Marx, Yosemite Sam, Gene Shalit, Charlie Chaplin, baseball Hall of Famer Rollie Fingers, surrealist artist Salvador Dali, and someone whose moustache is more famous than his name: Badamsinh Juwansinh Gurjarhis, who spent 22 years growing a 12.5-feet-long mustache, in an attempt to set a world record.
What's the attraction? Several mustachioed guys will give you a quick, practical answer: "It beats shaving."
Others may be convinced they're a babe magnet, with some justification.
"I love mustaches. I even liked them as a teenager. My husband Tony has a white moustache and goatee," said Patti Gruessing of Las Cruces. Hal Fore had a long relationship with his.
"I had a moustache for 40 years. I remember I still had it when I took a wonderful trip to Paris. Then, I just decided I wanted to see my face. I shaved it off and people said I looked younger," Fore said.
"I like the way it looks and it's easier with the right trimmers," said Robert Ramirez of Las Cruces, who reports that he's experimented with many kinds of facial hair, including embedded designs, with the help of Robert "Boomer" Burkhartsmeier of Zucos Barbershop.
Moustaches can even be a rallying point for a cause. Each November, the worldwide Movember movement invites men to grow a 'stache to "raise vital awareness and funds for men's health issues, specifically prostate and testicular cancer initiatives."
For information, visit www.movember.com.
If you're considering growing a 'stache of your own, or even if you're just a fan, you're in the right place.
Las Cruces was named the 27th most mustache-friendly city in the U.S. by the American Mustache Institute, which reportedly considered such factors as "large first responders pool (law enforcement, fire and rescue, EMTs); motorcycles, monster trucks and ATVs per capita; and restaurants serving pork rinds and pickled meats per capita."
Aggie mascot Pistol Pete was not mentioned, but may have been a factor in determining our 'stache status.
The American Mustache Institute sponsors everything from charity benefits to the National Beard and Mustache Championships (the 2012 event was held in Las Vegas in October), 'Stache Bashes and the recent Million Mustache March.
Information from: Las Cruces Sun-News, http://www.lcsun-news.com


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WASHINGTON -- Former CIA director David Petraeus will testify before the Senate Intelligence Committee on Friday concerning the Sept. 11 attack on the U.S. compound in Benghazi, Libya, news outlets are reporting.
Fox News says the former general is expected to speak off-site to the Senate Intelligence Committee.The House side is still being worked out. Petraeus was initially slated to offer testimony on the Benghazi attack, which left U.S. Ambassador Christopher Stevens and three other Americans dead, at a closed hearing before the Senate committee Thursday.
"Mr. Petraeus has indicated his willingness (to testify)," Senate Intelligence Committee Chairwoman Dianne Feinstein, D-Calif., told Politico.
Petraeus resigned last week over an extramarital affair. The resignation has since expanded to include Gen. John Allen, the top U.S. commander in Afghanistan. Allen reportedly exchanged "possibly inappropriate" e-mails with Jill Kelley, a Florida socialite linked to the Petraeus scandal.
(USA Today)


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Tulsa Wiki is hosted by the Tulsa City-County Library. It will eventually contain everything about Tulsa, Tulsa County, and items related to Green Country that impact Tulsa County. (e.g. Port of Catoosa, Hard Rock Casino, etc.).
If you'd like to contribute and need help getting started, visit http://www.tulsawiki.org/Help for instructions.
Facebook Twitter YouTube Flickr Library Apps Careers @ TCCL
400 Civic Center ~ Tulsa, OK 74103 ~ 918.549.7323


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Our faces have many features that cannot be treated as a single entity. Our skin has different needs around the eyes and lips as compared to our cheeks, forehead, and chin. The eye area tends to be quite delicate and sensitive while the lips often require added moisture to remain soft, smooth, and kissable. For these reasons, adding an eye treatment or a lip product into your skincare routing can often produce dramatic results. The MATIS Yeux product collection contains a number of ingredients that are specifically designed for the eyes (les yeux, in the French language) and a few that also treat the lips.
The MATIS Yeux lineup contains a treatment mask for the eyes and lips, a makeup remover product for the eyes and lips, and also a nourishing contour balm for the eye area. In many cases, MATIS Yeux products also lift the marks of time, leaving you with a more vibrant, younger looking complexion. This skincare collection relies on a number of active ingredients back by science to deliver the results your skin desires. MATIS Yeux eye products are gentle enough even for sensitive skin.
Our eyes are often one of the first features that other people notice about us. Eye contact occurs frequently during conversation and sometimes just as often when no words are spoken at all. Be sure to take great care of the skin around your eyes on a daily basis to ensure you always have a vibrant and beautiful look. The MATIS Yeux products offer many skincare benefits, including anti-aging effects, moisturizing properties, and improved appearance of the skin. This collection is suitable for all skin types, including sensitive skin.
MATIS Reponse Yeux Eyes and Lips Treatment Mask is a special treatment mask that restores radiance and improves the comfort of your skin. Marine elastin included in this skin remedy provides preventive anti-aging effects to help revitalize the skin around your eyes and lips. This skin treatment mask alleviates dehydration lines and wrinkles, softening your skin and delivering nourishing nutrients.
MATIS Reponse Yeux Biphase Eyes and Lips Make-up Remover is a quick and effective makeup remover that is designed especially to clear away makeup and residue from the eyes and lips in one fast step. Even waterproof makeup vanishes without smudging and smears. The ophthalmologist-tested formula soothes and softens the skin without leaving any annoying oils or films on the eyelids. This eye makeup removing solution is well suited for sensitive skin and all other skin types.
MATIS Reponse Yeux Eye Contour Balm helps to firm, nourish, and revitalize the delicate skin around the eye area. This high-performance formula tones the skin and repairs damage around the eye area. The result is a younger-looking appearance and skin that is well hydrated.


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Around the Horn perspective: "You Don't Know Bo"
The newest ESPN "30 for 30" airs tonight (December 8, 8 C.T. on ESPN) after the Heisman Trophy announcement and features a winner of the Heisman – one Bo Jackson. Bo's story is one that always has sports fans saying…what if? What if his football injury had not happened?
While the injury was devastating, the film has a lot of humor as it traces Bo's story from Bessemer, Alabama to the current day. We'll leave most of the details a surprise and just say that this is a MUST SEE for any Royals fan (or sports fan or…anyone, for that matter).
You'll see interview clips with: George Brett, Mark Gubicza, Royals beat writer Dick Kaegel, Royals Hall of Fame Director Curt Nelson and Royals Senior Advisor Art Stewart.
Below are details on my perspective as to how the "30 for 30" unfolded.
In May, I received a call from Kelsey Field, associate producer of "You Don't Know Bo" for Radical Media. I helped her with background information and photos. She wanted to get in contact with people who knew Bo during his time in Kansas City. Jackson signed with the Royals in 1986 and many of the people who knew him have moved on. He was signed by Ken Gonzales, who sadly passed away in 1994. I checked with former scouting director and current senior advisor Art Stewart, who is a great baseball storyteller. He knows Bo well and was more than happy to speak with Kelsey by phone.
Fellow media relations staffer Dina Blevins arranged a time for Hall of Famer George Brett to talk with the production staff by phone (so they could get more information for the eventual on-site interview). Kelsey worked with our media relations boss, Mike Swanson, to arrange a date for production in Kansas City. Radical's staff had several other stops to make – including Jackson's hometown in Alabama, Auburn, L.A., Chicago and Nike's headquarters in Oregon. Radical had to match up their schedule with interviewee availability of George Brett, Art Stewart and Dick Kaegel. And don't forget…we had to work around our own busy schedule with the All-Star Game on July 10!
Radical's team visited Kansas City on July 17 and 18. They took exterior shots of The K on July 17. The next morning, they interviewed George Brett and spent time with him on the field. Members of the staff had a few minutes between interview segments with Art Stewart and Dick Kaegel. I suggested a trip to the Royals Hall of Fame to get b-roll of Bo Jackson items that were in storage. They met with Royals Hall of Fame director Curt Nelson. Film director Michael Bonfiglio was so impressed with Curt that he asked him to interview for the piece!
When you wake up each day, you never know what may happen. Curt knew that the "30 for 30" crew was coming to Kansas City, but he had no idea that he was going to be interviewed. As you watch the story unfold, you'll see Curt's comments were in several parts of the film. Curt hired me in the marketing department nearly seven years ago. He is a good friend and I am happy that he got the opportunity to share his views of Bo's story.
Enjoy the show!
1 Comment
Very interesting…'glad to learn details about the project.
So glad for you and know you love your job. : )


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Paid: I expect to pay $100 for the project, via PayPal. I'll negotiate with the artist once we've determined that we're a good fit.
I need 1 map of a fantasy nation that I have created for a theatre play I am writing, directing and producing. The map will be used on the programs, posters and other marketing materials for a June, 2012 production. For more information on the production, please visit www.indiegogo.com/thewallBrooklyn.
It will be a map of a future nation surrounded by water on three sides, with 10 honeycomb reserves (walled-in communities), inside the land. It should be perhaps 50 miles to an inch. About the size of Israel. I'm happy to follow the artist's lead on the proper scale for what I want.
In addition, it would be great to find an artist who could illustrate/design a great looking title/brand logo that could be incorporated into the map.
I think a more illustrated or painterly, archaic style is appropriate, though it doesn't need to be actually hand-drawn or painted. Here are a couple examples of what I am looking for:
Quality & Size
The maps should be professional quality. I'm paying, which would by definition make my expectations "professional."
Will be used for both web viewing and in print. If the style permitted a grayscale version for black and white photocopies, that would be ideal.
Size...suitable for full-size viewing on a typical computer screen, 8 X 12 page, postercards.
Time Constraints
I would like to have a draft of this map by early May and the final version by mid-late May 2012, if at all possible. Somewhat negotiable.
I will have the right to use the image for commercial purposes, the artist will have the right to exhibit the image as part of his portfolio.
Contact Details
Look forward to hearing from you!


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Software radio (or software-defined radio, SDR) is an engineering pursue in wireless communication technology field that one day all wireless signal processing functions, which are typically implemented in hardware today, will be done completely in software. Over the years, researchers and engineers have made remarkable progress and have been constantly pushing the hardware-software boundary. The Microsoft Research Software Radio (Sora) is one such recent success in advancing the state of the art in software radio technology.
Principle and Architecture
The goal of Sora is to develop the most advanced software radio that is capable of implementing the state-of-the-art wireless communication technology easily and efficiently. In late 2000s and early 2010s, the state-of-the-art is Wi-Fi and LTE. The implementation platform must then be able to handle OFDM, 64QAM, MIMO, CSMA, 40MHz channel width, and tens to hundreds Mbps data rate. This is a significant challenge for any software radio.
There are many ways of building high-performance software radios. We choose commodity PC as the underlying platform. PC does have the advantage of a familiar environment with rich programming tools and ecosystem supports, but meeting the astronomical demands of signal processing in PC software and in real-time seems quite "mission impossible" to many people.
> See how we solve this -- the Principle and Architecture of the Sora Approach
Sora has been used to implement and run the-state-the-art wireless standards including Wi-Fi and LTE. For Wi-Fi, Sora is able to do 802.11 a/b/g/n in full data-rate (up to 40MHz channel, up to 64QAM, up to 4x4 MIMO). The actual data rate is limited by the speed of the PC, but we have accomplished 802.11 data-rate up to 300Mbps. Spectrum-wise, Sora supports a wide range of radio front-end options, from standard Wi-Fi (ISM bands) to TV Whitespace (TVWS), in both single antenna setting and in 4x4 MIMO setting (8x8 also possible).
In Sora, you write your entire baseband in C language. A highly optimized implementation of 802.11 a/b/g/n PHY is available in source code (so you can learn about Wi-Fi implementation or learn how to program in Sora). The SDK also comes with a rich set of common signal processing library (from FFT to Viterbi decoding, etc.) so you can reuse. The program model in Sora currently includes a vector computation library called Vector1 and a modular data-flow composition system called brick, both of which can help programmers to write high-performance baseband programs. Further, the SDK includes various tools, like helping users debug their signal processing programs, visualizing Wi-Fi decoding, etc.
Research Scenarios and Showcases
With Sora's ability to run high-speed wireless systems in software, it becomes a powerful yet convenient tool for research and development in the wireless communication technology field. Here is a few examples that showcase Sora's achievements.
Wi-Fi PHY and MAC Research
The PHY and MAC have been an active research areas for many years. New improvements have been frequently proposed on new PHY and MAC algorithms. However, experimental studies are extremely difficult to do at the bottom layers of wireless network. Without open software radio, these layers are all but hidden in the commerical hardware and totally out of reach for ordinary researchers.
Sora is capable of running Wi-Fi at hundreds of Mbps in software and in real-time. The entire Wi-Fi PHY implementation is written in C and is open-source. Researchers can now modify the source code to implement their ideas and validate them in real over-the-air experiments.
> More on other successful wireless network research using Sora
Whitespace Research
TVWS basestationTV Whitespace (TVWS) and dynamic spectrum access (DSA) is a hot research topic in wireless networking. To cover TVWS bands and extend the outdoor range, we have built a 40MHz front-end option that operates in the 500MHz-700MHz band with a 1-4W configurable amplifier. It supports both single antenna and 4x4 MIMO setting, making Sora a very useful TVWS research platform. For example, we have rolled out a cellular-type TVWS research network to cover the Microsoft Redmond campus. Each basestation is just a PC plus four roof-top TVWS antennas. Everything else is software based on Sora.
- Kun Tan, Haichen Shen, Jiansong Zhang, Yongguang Zhang, "Enable Flexible Spectrum Access with Spectrum Virtualization," IEEE DySPAN 2012.
- Project Istanbul: TV Whitespace network for Microsoft Redmond campus.
MIMO Research
12x12 MIMO with SoraMIMO (Multi-Input Multi-Output) is an important new wireless technology to increase data throughput in the wireless channel by adding multiple antennas. In theory, more antennas will lead to higher throughput gain, but in practice we seldom see more than four antennas in consumer products or in commercial uses. In fact, there haven't been many reported studies or trials to build MIMO system with more than 10 antennas.
One reason is the complexity of signal processing in large MIMO system. It will be tremendously difficult to build custom hardware and develop FPGA codes. However, software radio may have the advantage of being scalable and easy to program. Indeed, we put together 3 Sora 4x4 MIMO kits and a dozen server PCs to build a big software radio with 12 antennas -- to achieve close to 7 times throughput gain!
> See how we build large MIMO systems and conduct MIMO research with Sora
The Sora Academic Kit
When Microsoft Research first demonstrated the capability of Sora technology in 2009, there was a lot of excitement in the research community about its potentials. Microsoft Research then decided to share this discovery and the technology with academics, aiming to encourage the use of software radio in wireless networking research. An academic program was created and a team formed in Beijing, China to build and maintain the Sora Academic Kit. Today, Sora has more than 50 institution users and it has driven many wireless research projects around the world.
> More about the Sora Academic Kit and how you may use it for your research
Quick Links
|Sora WiFi Demo (Jan 2011)
History: the Sora Project
The Microsoft Research Software Radio (Sora) project started as a "blue-sky" research project in the Wireless and Networking Group at Microsoft Research Asia (Beijing, China) around 2007. The goal was to advance the state-of-the-art in software radio and build a platform that can achieve wireless performance orders of magnitude better than existing systems.
In 2009, it surprised the world when it first demonstrated the ability to run a full-rate 802.11 entirely in PC software, which was never thought possible before. In 2010, Microsoft Research created an academic program and release the Sora Academic Kit to share this technology with the research community. Today, Sora has facilitated many wireless R&D around the world.
- 2007 Project started.
- 2008 First internal demo of 802.11b.
- 2009 First public demo of 802.11a/b/g, NSDI best paper.
- 2010 Sora Academic Program started.
- 2011 Sora Academic Kit v1 released.
- 2013 Sora Academic Kit v2 (MIMO) released.


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ATLANTA, Ga. -- One person is dead after a shooting at the intersection of Martin Luther King Jr. Drive and Paschal Boulevard in Atlanta.
The shooting happened in close proximity to the Atlanta University Center.
The other victim is in critical condition at Grady Memorial Hospital. The preliminary investigation showed that the shooting occurred in the 400 block of Paines Ave and the victims left the scene in the vehicle.
Anyone with information on the incident is asked to contact Atlanta Police Homicide Detectives at 404-546-4235 or Crime Stoppers at 404-577-8477.


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May 25, 2016
Tallahassee, FL - Amber Colvin is a Tallahassee native and professional race car driver.
"Everyone finds out I'm a female race car driver and says 'oh you want to be like Danica Patrick,' well no I want to be an Amber Colvin I want to be myself," she said.
Colvin's racing days started when she was a kid. Her dad gave her a yard kart at ten.
She's been interested in driving professionally ever since.
"If I'm not at the race track or doing something with racing, I'm not sure what I should be doing," Colvin said.
"She does a great job, she gets out with grown men and does what they do and whoops em," said Wayne Colvin, Amber's dad.
Now 19 years old and living in North Carolina, she's a full time race car driver.
She won first place at the 8th week of the 2012 summer shootout series at the Charlotte Motor Speedway.
"Ultimately, I want to be the first and or the youngest female to win a Nascar event or championship," she said.
Colvin takes pride in the accomplishments in her career, but she said being a woman in a male dominated sport comes with roadblocks in gaining support.
"Definitely the sponsorship hunt is what I do day to day, week to week and my dad helps me out a lot with that," she said.
Colvin plans to start college soon, but will continue on her career in racing.
Colvin is the 2011 Florida State Legend Car Champion. This year, she will race in the Nascar Whelen All American Series.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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The smart way to keep your baby cool in the warmer weather!
*Please note this smart mesh seat comes fully assembled
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*V2 seat frame fits smart V1 buggy


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- MedicalStudent.com's Medical Textbooks
- Medical textbooks and other e-texts on subjects from Anatomy to Wilderness Medicine. Some are collections of articles written specifically as an e-text; others are older editions of standard texts such as the 1917 ed. of Gray's Anatomy.
- Oral Health in America: A Report of the Surgeon General


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It is happening even more frequently that some of our users find that their attachments have been sent with a size of 0 B, then the recipients get an error because the attachment is present but empty.
The sender realizes that the attachment has been sent with a 0 B size only after the mail has been sent, when he looks for the mail into the 'Sent' folder.
I cannot figure out how this happens and I cannot reproduce this behaviour.
Users are all using ZD 1.4 and ZCS is at its latest version.
Can you guess how it can happen?


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Quote BigAl:Tim, I'm sorry but
I do not agree about a 3 - 5 year life for my recording equipment....
Quote tim_obrien:Often its not
just hardware but the drivers aren't updated and won't work on modern OS's. Mac users
have just gone through the switch to Intel chips where old PowerPC programs wont work on
the last two OSs and Windows has been threatening for years to rewrite an upcoming Windows
that'll be completely incompatible with new hardware.
Quote BigAl:I don't need to much
sophistication. Just good quality, reliability and low latency.
Quote BigAl:It's ridiculous to
say that if I buy an 8 channel preamp / sound interface, it's going to be obsolete in 3
Quote:Maybe a line only interface is the way to
Quote BigAl:...and maybe
firewire isn't quite dead yet, especially if the thunderbolt adapters work.
Quote Hugh Robjohns:
It's kinda in your own hands. I still run an XP machine to retain compatibility with
some favoured decade-old hardware that would otherwise now be obsolete...
Quote Hugh Robjohns:I still run
an XP machine to retain compatibility with some favoured decade-old hardware that would
otherwise now be obsolete...
Quote BigAl:2. USB 3.0
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Sound On Sound : Est. 1985


text:
Rank and organization: Landsman, U.S. Navy. Born: 1838, New York. Accredited
to: New York. G.O. No.: 17, 10 July 1863.
Citation: Served on board the
U.S.S. Cincinnati during the attack on the Vicksburg batteries and at the
time of her sinking. Engaging the enemy in a fierce battle, the Cincinnati,
amidst an incessant fire of shot and shell, continued to fire her guns
to the last, though so penetrated by shellfire that her fate was sealed.
Serving bravely during this action, Corcoran was conspicuously cool under
the fire of the enemy, never ceasing to fight until this proud ship went
down, "her colors nailed to the mast."
This data was extracted from the Committee on Veterans' Affairs, U.S. Senate, Medal of Honor Recipients: 1863-1973 (Washington, D.C.: Government Printing Office, 1973)


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Gramma2five wrote:I have been very vocal and on record in this forum over the years and others as being against Shaddam. I was and always will be a Schick fan. I was never a fan of Adam and Sharon because I could never get over the fact that Sharon could love the man that kidnapped( yes he really did kidnap, no play on words) her and Nicks baby and keep quiet for months. However, with Justin Hartleys "Adam" and the way these horrible writers are writing for Sharon, I think this may be the only way out for her is to reunite Shaddam. Sharon needs somebody to stand behind her and Nick is going to be furious and Dylan is going to be furious. She will be the town with again... So sick of it.
I am thinking Adam and Sharon can raise baby Sully (Christian) together.
Return to "The Young and the Restless"
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Cancer is a major cause of human death worldwide. The vast majority of cancer patients suffer from solid tumors whose growth destroys vital organs. We propose to develop novel therapeutic drugs that target solid tumors affecting the brain, colon and ovaries. These cancers account for a significant proportion of currently intractable solid malignancies.
Scientists have made great strides in understanding the molecular and cellular changes that cause cancer but the approval of new therapeutics that can specifically kill cancer cells has lagged behind. This disparity suggests that there must be critical bottlenecks impeding the process of turning a basic research discovery into a finished anti-cancer drug. Research over the past decade has given rise to the idea that one of these bottlenecks may be caused by the existence of cancer stem cells. According to the cancer stem cell hypothesis, there is a minor population of cancer stem cells that drives the growth of the entire tumor. However, cancer stem cells are very rare and hard to identify. Technical innovations have recently allowed the identification, isolation and growth of these cells in the laboratory, and it has become clear that they have properties that are distinct from both the bulk of tumor cells and the cancer cell lines usually used to test anticancer drug candidates. Furthermore, in the lab, cancer stem cells are resistant to the chemotherapy and radiation treatments used to kill most tumor cells. In a patient, cancer stem cells may not be killed by standard drugs and may eventually regrow the tumor, causing a cancer to relapse or spread. Thus, a drug that specifically targets cancer stem cells could dramatically improve the chances of treatment success.
Our team is one of the few in the world that can identify cancer stem cells in brain, colon and ovarian tumors. Furthermore, we have developed assays that can accurately test the effectiveness of drug candidates in killing these cells. Our preliminary data suggest that our lead drug candidates can inhibit the growth of cancer stem cells in culture and block tumor initiation in animal models. Importantly, our drug candidates appear to work through mechanisms that are different from those employed by current chemotherapeutics, meaning that our drugs represent a fresh and potentially very effective approach to cancer treatment. Over the next several years, we propose to complete our development and preclinical studies of these drugs so that testing in cancer patients can begin.
Our proposal may benefit the state of California in four important ways. First, solid tumors cause significant morbidity and mortality. We propose to develop 2-3 Investigational New Drugs (INDs) to treat colon, brain and ovarian tumors, which are often difficult to treat with conventional therapies and are associated with poor prognoses. Thus, the proposed INDs should lead to a decreased burden on the California health system.
The second benefit arises from our novel approach to drug development, a route that other researchers may emulate. Most targeted cancer drugs fail in clinical trials, despite our growing knowledge of the molecular and cellular causes of cancer. These failures indicate that there are rate-limiting factors in the way basic research is currently translated to cancer drug discovery and development. One such factor may be related to a major new hypothesis in tumorigenesis, which states that a minor population of cancer initiating cells (CICs) drives bulk tumor growth. These CICs appear to survive existing therapies that kill most tumor cells, and so can go on to initiate relapses and metastases. A second rate-limiting factor may be the heterogeneity that exists both among and within different tumor types. Both of these "bottleneck" factors can be obviated by the molecular characterization and comparison of CICs and bulk tumor cells. Knowing the features that distinguish CICs from bulk tumor cells will facilitate a targeted drug development plan that optimizes chances for clinical success. We have devised such a strategy based on the integration of solutions to these limiting factors into a state-of-the-art drug discovery platform. This strategy may provide a foundation for the rapid extension of our approach to the treatment of other solid tumors.
The third benefit is the linking of CIC identification to clinical outcome. The ability to isolate and propagate CICs from solid tumors is a recent innovation. We will perform a thorough genetic examination of the alterations in these cells that lead to oncogenesis. Because we intend to carry out this work in parallel with the characterization of tumor samples from patients with documented clinical outcomes, we will be able to correlate the nature of particular CICs with similarities/differences among human tumors in a way that identifies features statistically linked to poor outcomes. This information will allow the selection and validation of additional drugs so that a pipeline of ever more refined compounds is established even if initial attempts fail in the clinic.
The fourth benefit falls directly in line with the focus of California's robust biotechnology industry on drugs to address unmet medical needs. Our data and methods will be published and readily available, and so can be applied by existing and emerging biotech companies. Great advances in novel targeted therapeutics to treat solid tumors should be realized, expanding the drug development expertise of the state.
The objective of our collaborative project is the development of therapeutic candidates that will form the basis of IND submissions designed to test a novel class of drugs for the treatment of tumor initiating cells (TICs) in three solid human malignancies where TICs have been implicated in the pathogenesis of disease. The target profile is the TIC population in colon cancer, ovarian cancer and glioblastoma. The therapeutic compounds that have been developed in the course of the collaboration target a pair of serine-threonine kinases that act at the nexus of mitosis, hypoxia, and DNA repair. These enzymes are over-expressed in many forms of cancer and alterations in their expression patterns correlate with dysregulation of a number of genes that are significantly linked to poor patient outcome.
Compounds against the first target have been developed to the point at which a developmental candidate can be selected. The compounds show single digit nanomolar potency in vitro, adequate specificity, appropriate pharmacokinetics to support oral delivery, and the ability to trigger growth inhibition and cell death in a wide panel of tumor cell lines and TICs from the three targeted histologies. Recently completed dose and schedule studies have been used to design and implement tumor model studies. The compound that demonstrates the widest therapeutic index will be selected for IND enabling studies. These IND enabling studies will include synthetic scale-up, toxicity evaluations, combination studies, mechanism of action studies, and a biomarker identification program that will be used to identify a targeted population for optimal clinical trial design.
The medicinal chemistry program against the second target was started approximately 15 months after the initiation of the effort against the first target. Sufficient potency, specificity, and activity against tumor cell lines and TICs have been demonstrated with novel molecules. Current efforts are focused on improving the pharmacokinetic properties of the drug candidates.
A phospho-flow platform to measure mRNA levels, protein levels, and enzymatic activity using a mass spectrometric readout has also been tested. This system enables the simultaneous measurement of up to 35 different biomolecules. A data management system has been developed to facilitate the associated complex data analysis. Proof or principle experiments have demonstrated that this experimental paradigm can be used to reconstruct the developmental lineages of all progeny downstream of hematopoietic stem cells from human and mouse bone marrow. This approach has recently been applied to the analysis of ovarian cancer cells taken directly from patients. The results of these studies suggest that cancer cells are clearly heterogenous, but perhaps most importantly can be organized into developmental lineages that are formally similar to those seen in bone marrow development. Furthermore, this platform can assess the response of individual subcomponents of the oncological lineage to both approved and experimental drugs. We will be using this platform to gain insight into how tumors respond to individual drugs, including our drug candidates, and combination studies. It is reasonable to expect that it will be possible to not only assess the response of the cancer stem cells, but all subtypes of the tumor lineage.
Slamon Mak Cancer Stem Cell Abstract
Drug discovery programs against two different mitotic kinases are being pursued. Both programs follow the same general process flow in which lead optimization experiments culminate in the selection of a single small molecule candidate for advancement to preclinical development. The development candidate then proceeds through a standard series of evaluations to establish its suitability for an IND submission and use in subsequent clinical trials.
CFI-003 was selected as a clinical development candidate and is progressing through investigational new drug application (IND)-enabling studies. Chemistry activity in the past year has included the selection of the fumarate salt as the final salt form, and production of two kilogram-scale clinical batches, the first of which is scheduled to be released at the end of April. The compound is stable when stored under typical storage conditions, and has an impurity profile that is safe for clinical dosing. In cancer models, CFI-003 was shown to be particularly effective against tumors deficient for the tumor suppressor gene PTEN; this is important given that deficiencies in this gene are generally considered to be an indicator of poor prognosis in the clinic. Experiments are ongoing to determine biomarkers of response to CFI-003 for application in the clinic. Other work includes selection and management of contract research organizations (CROs) for critical IND-enabling studies. For example, Pharmatek has been engaged to assist in the development of a drug formulation that enhances the stability of CFI-003, and maximizes bioavailability of the compound when dosed orally. Other CRO work that is ongoing involves in vitro pharmacology experiments geared toward understanding how CFI-003 might interact with co-administered drugs, and performing key toxicology experiments for determination of a safe and effective clinical dose of the compound. An important milestone was reached in the previous reporting period in that the patent application covering CFI-003 was allowed by the US patent office. The CFI-003 IND development team will continue to move the project forward planning for a successful IND submission toward the end of Q1 2013.
The drug discovery efforts in the second program have been focused on improving the pharmacokinetic properties of the lead series molecules while maintaining excellent in vitro activity. Approximately 400 new chemical entities have been synthesized during the last reporting period. Progress to date has been measured by an increase in potency in the biochemical assay and improved anti-proliferative potency in cancer cell growth assays. Activity toward Aurora B has simultaneously been attenuated, and current compounds demonstrate improved selectivity against a diverse panel of kinases. Progress was aided by the acquisition of multiple co-complex x-ray structures which allowed for further refinement of binding models to the target's active site. Compounds to be qualified for further study must continue to induce an aneuploidy phenotype at least an order of magnitude above the HCT116 (colon adenocarcinoma cell line) GI50, and importantly must also demonstrate adequate plasma levels upon oral dosing. A lead series compound has been shown to have oral efficacy in a cancer model. To follow up this result, additional compounds have been scaled up for testing. Experiments to determine the tolerability have been completed for the latest candidates and further efficacy studies have been initiated. Results from these efficacy studies will aid in the identification of a development candidate for subsequent IND enabling studies.
Drug discovery programs against two different mitotic kinases are being pursued. Both programs follow the same general process flow in which lead optimization experiments culminate in the selection of a single small molecule candidate for advancement to preclinical development. The development candidate then proceeds through a standard series of evaluations to establish its suitability for an IND submission and use in subsequent clinical trials.
CFI-400945 was selected as a clinical development candidate. The IND-enabling studies included the selection of the fumarate salt as the final salt form, and the production of two kilogram-scale clinical batches, which have been released during the past year. The compound is stable when stored under typical storage conditions, and has an impurity profile that is safe for clinical dosing. In cancer models in mice, CFI-400945 was shown to be particularly effective against specific subsets of tumor cell lines in both tumor cells grown in soft agar and in xenograft models. Experiments are ongoing to determine biomarkers of response to CFI-400945 for application in the clinic. Pharmatek was engaged to assist in the development of a drug formulation that enhanced the stability of CFI-400945, and maximized the bioavailability of the compound when dosed orally. Other CRO work that was completed included in vitro pharmacology experiments geared toward understanding how CFI-400945 might interact with co-administered drugs, and performing key toxicology experiments in animals for determination of a safe and effective clinical dose of the compound. This work culminated in an IND submission in the second quarter of 2013.
The drug discovery efforts in the second program has focused on improving the pharmacokinetic properties of the lead series molecules while maintaining excellent in vitro activity. Approximately 400 new chemical entities were synthesized and tested using a battery of biochemical and cell-based assays. Off target activity towards Aurora B has simultaneously been attenuated, and current compounds demonstrate improved selectivity against a diverse panel of kinases. Progress was aided by the acquisition of multiple co-complex x-ray structures which allowed for further refinement of binding models to the target's active site. Compounds were qualified for in vivo study based on the induction of an aneuploid phenotype at an order of magnitude above the HCT116 (colon adenocarcinoma cell line) GI50, and importantly the demonstration high mouse plasma levels upon oral dosing. Mouse xenograft studies based on a number of tumor cell lines were used to select a short list of compounds. The aggregate data was then used to select a developmental candidate CFI-1870. IND enabling studies have been launched. In parallel, detailed dose and schedule studies are underway along with approaches to identify susceptible tumor subpopulations and associated biomarkers that will eventually support a targeted clinical trial.
The Slamon/Mak cancer stem cell drug discovery program funded by CIRM/CSCC has achieved two important milestones in the past year. Our first therapeutic candidate was approved by the FDA and first-in-human dosing of CFI-400945 has taken place as part of the Phase I clinical trial. In our second program we have selected a development candidate that is now in the midst of IND ennabling studies
The clinical trial is being carried out at Princess Margaret Cancer Centre (Principal Investigator, Dr Philippe Bedard) and UCLA (Principal Investigator, Dr Zev Wainberg). This clinical trial was initiated after a number of milestones were successfully met following the submission of the IND and CTA in 2013. These have included making improvements to the formulation of the CFI-400945 tablets resulting in the successful reduction of the appearance of a degradant that was slowly accumulating in the initial formulation. This enabled the manufacturing of the cGMP tablets for use in the clinic in September 2013. These formulation changes and the Certificates of Analysis of these tablets were submitted to the FDA and permission was granted to begin clinical evaluation. In December 2013, we were awarded the CIRM Disease Team III funding to continue the CFI-400945 program which enabled the planning and initiation of this Phase I clinical evaluation and additional non-clinical studies.
In our second program, Pyrazolo-pyrimidines have emerged as the most promising class of 3rd series TTK inhibitors. TTKis with potent in vitro activity, excellent oral exposure in rats and in vivo efficacy were identified. A short list of 5 pyrazolo-pyrimidines was identified as potential third series development candidates. After further characterization it was determined that 4 or 5 compounds met the preponderance of the selection criteria, 2 of which had outstanding PK properties. The TTK inhibitor CFI-402257 had the best balance of efficacy, PK and off-target activities and was selected as the development candidate. IND enabling studies with 402257 have been initiated, and will continue during the no cost extension period of the grant.
CFI-402257 was selected as the IND-development candidate for the TTK inhibitor program. During the past year this molecule has progressed through IND-enabling studies. ADME studies and in vitro mechanism of action characterization have been completed. The synthesis of the compound has been scaled up and batches of material have been produced for both formulation development and the toxicology program. A formulation suitable for dosing rats and dogs in the toxicology program was identified and all in-life activity in the toxicology program has been completed, with the study reports now being generated. Development of the clinical formulation (formulated powder-in-capsule) is well advanced and the GLP synthesis of the drug substance for use in the clinic is nearing completion.
In addition, we have performed in vivo combination studies with CFI-402257 and the PLK4-inhibitor CFI-400945. We designed a combination MTD for CFI-402257 and CFI-400945 to identify tolerable combination doses in non-tumor bearing mice. These data were used to inform the design of a combination efficacy study using the HCT116 colon cell line xenograft model. Significantly increased tumor growth inhibition was observed in the combination arm relative to either inhibitor alone. Even at single agent MTD, CFI-402257 and CFI-40945 induced tumor growth inhibitions of between 40-70% whereas the combination induced a tumor growth inhibition of >100%. These studies are being replicated with bisphosphate form of CFI-402257 and will then be tested in additional cell line xenograft models to test the potential efficacy of this combination therapy.
Finally, we have developed immunofluorescence assays to detect Plk4 and TTK in formalin-fixed, paraffin-embedded (FFPE) cancer cell lines as well as in FFPE tissue samples. Our Plk4 immunofluorescence methods localize either full-length Plk4 or cleaved phopho-Plk4 depending on the primary antibody used. We have shown a correlation between Plk4 expression levels measured per 500 tumor cells by immunofluorescence and responsiveness to Plk4 inhibitor in colorectal cancer cell lines. We consider Plk4 expression levels, determined by immunofluorescence, to be a potential predictive biomarker assay that we will evaluate in tissue samples from the phase I trial of CFI-400945 Plk4 inhibitor.
- Nat Med (2014) Multiplexed ion beam imaging of human breast tumors. (PubMed: 24584119)
- Cell (2014) Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. (PubMed: 24766814)
- Curr Opin Immunol (2013) Single-cell mass cytometry for analysis of immune system functional states. (PubMed: 23999316)
- Interface Focus (2013) Single timepoint models of dynamic systems. (PubMed: 24511382)
- Cytometry A (2012) Single-cell mass cytometry adapted to measurements of the cell cycle. (PubMed: 22693166)
- Science (2011) Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. (PubMed: 21551058)
- Nat Biotechnol (2011) Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. (PubMed: 21964415)


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CHARLOTTE, N.C. -- The state released Friday the autopsy and toxicology reports of a man killed by a Charlotte police officer in early September.
The reports, obtained by WBTV, confirm Jonathan Ferrell died from multiple gunshot wounds to his chest. The toxicology report says he had caffeine, nicotine and ethanol in his system.
Officer Randall Kerrick shot Ferrell 10 times, according to WBTV. He is charged with Voluntary Manslaughter and is on paid leave during the investigation.
The officers gave several verbal commands to 'get on the ground, get on the ground', at least three commands," George Laughrun, Kerrick's attorney, told WBTV. "He continued approaching the officers, advancing toward them."
Chris Chestnut, the Ferrell family attorney, told WBTV, "[Kerrick] knew what he was doing. He shot, paused, shot again. Paused, shot again -- he killed."
Chestnut also emphasized to WBTV that Ferrell was outnumbered by officers three to one. "These are trained officers, trained in defensive tactics. Three to one, no need to shoot," he said.


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Durable goods orders are up in January, but supply chain concerns linger
February 25, 2011
In a sign that the economic recovery is showing some more positive signals, the Department of Commerce reported this week that new orders for manufactured durable goods in January went up $5.3 billion—or 2.7 percent—to $200.5 billion.
Commerce said this increase follows three straight monthly declines, with December down 0.4 percent being the most recent one. And excluding transportation, new orders in January were down 3.6 percent, with transportation equipment saw the largest monthly increase after three months of declines, with January coming in at $10.9 billion—or 27.6 percent—to $50.5 billion.
And shipments of manufactured goods, which have been up in four of the last five months, rose $0.6 billion—or 0.3 percent—to $202.9 billion. Durable goods inventories, which have been up for 13 straight months, were up $2.2 billion—or 0.7 percent—to $324.8 billion.
This data follows a release from the American Trucking Associations earlier this week, with the ATA stating that its For-Hire Truck Tonnage Index was up 8 percent annually in January.
Other positive signs, as previously reported by LM, include sustained manufacturing growth as reported by the Institute for Supply Management, increasing retail sales for the last seven months, and growing consumer confidence levels.
"The recovering is picking up steam," said FTR Associates Managing Director and Senior Consultant Noel Perry. "It is on a pace to surprise most economists, assuming there is no major oil shock."
But whether or not an oil shock occurs, diesel and oil prices are continuing a steady upward march, which has the potential to wreak havoc on shippers' supply chain budgets
And while shippers and carriers remain both cautious and confident about the economy, they also point out that challenges and obstacles remain in their path.
Among the reasons cited for this are increasing commodity prices, coupled with the US deflating its currency to try and encourage exports, although the strategy is having the opposite effect as imports cost more, according to Vin Gulisano, CEO of ParcelPort, a New Haven, Connecticut-based 3PL.
"The economy, while better still can't handle major inflation so companies are doing everything possible to not raise prices," said Gulisano. "Fragile is the word when talking about the U.S. economy. As a result it's getting very nasty in the Supply Chain. The customers at the top of the food chain finally see sales moving up and customers spending again, and they think that price increases could derail this. I'm not sure how all of this is going to end up. If history is any indicator, prices will go up but slowly. It's just great to be talking about growth again."
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Stormwater Management in Portland
The federal Clean Water Act, Safe Drinking Water Act, and Endangered Species Act require the city to manage stormwater runoff to protect water quality in rivers and streams, protect watershed health, and protect groundwater as a drinking water resource.
The city's federal stormwater permit requires Portland to reduce stormwater pollution, and manage other programs that respond to water quality requirements.
Environmental Services coordinates the city's response to the federal permit.
Environmental Services also coordinates the citywide response to the Water Pollution Control Facilities (WPCF) permit issued by the Oregon Department of Environmental Quality (DEQ). To protect groundwater quality, the WPCF permit requires the city to develop and implement a UIC management plan (UICMP) that prevents, minimizes, and controls pollutants at the surface before stormwater infiltrates into the ground.
Portland finances stormwater management services by collecting public utility fees on developed property, and system development charges (SDCs) on new development.
The city works with citizens, businesses, and property owners to increase public awareness of stormwater issues and promote private stormwater management efforts.


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Rumson Burying Ground, Rumson Road, Rumson, Monmouth County, NJ
Transcription:The "Rumson Burying Ground" is located at the corner of Route 520 / Rumson Road and Conover Lane just past the eastern end of Rumson Country Club. Oral history had it that the grounds were used as a Quaker graveyard and were possibly a native american cemetery. One marker which was mostly below ground appeared to be of a style similar to those used in other Quaker cemeteries but the local group asserts no claim to the grounds.
Resposibility for maintenance of the grounds has been the subject of a recent lawsuit in which a McCarter descendant, George W. C. "Bill" McCarter, asserted that First Union National Bank had negligently run a trust fund created for the purpose. The suit was settled this year (2001) and the bank agreed to settle the suit by paying $20,000 which is the total of two amounts previously paid into the trust. Rumson Borough plans to invest the money and use the investment proceeds for the purpose of funding normal maintenance.
We made a casual inspection of the site and wonder how the interest from $20,000 can possibly hope to pay for the substantial amount of work the cemetery needs. The grounds' landscaping, while by no means in horrendous condition, could defintiely use some work. There are a number of very old trees which have been completely engulfed by ivy. At least one large tree is dead and should be removed lest its large, dead branches be blown down by a Nor'easter and destroy some of the headstones.
The headstones are, with a few exceptions, in very good condition though some are in dire need of a good cleaning. Some of the stones have significant damage from moss and mold. A few stones have ivy attached at or near the inscription. A Boy Scout project righted and reset numerous stones which had toppled through the years but there are a few more which have fallen and cracked. Some of these should be buried to preserve the integrity of the memorials they hold. A few including the one seen above have already been lost forever.
In closing, we hope Rumson is up to the task of maintaining this very important monument to the early history of North America in general and Monmouth County in particular. We applaud the efforts of Bill McCarter to hold the bank responsible for the trust fund and hope that these funds prove sufficient for the purpose.
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Drive and Dish: Who's Your Coach of the Year?
Full disclosure: I, obviously, do not actually have a Coach of the Year ballot. That said, I think this year's race is really interesting, so I'm going to tell you who would be on my ballot, first in no particular… Continue Reading


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Jonesboro, AR (SportsNetwork.com) - Alonzo Harris rushed for 105 yards and two
touchdowns on 29 carries to lead Louisiana-Layfayette to a 23-7 triumph over
Arkansas State on Tuesday at Liberty Bank Stadium.
Terrance Broadway finished 18-of-28 passing for 205 yards with an
interception, while Elijah McGuire racked up 110 yards on 10 carries for the
Ragin' Cajuns (5-2, 3-0 Sun Belt), who have ripped off five straight wins
since opening the season with back-to-back losses.
Adam Kennedy struggled under center for the Red Wolves (3-4, 1-1), completing
just 11-of-20 passes for 89 yards with an interception while scoring the
team's only touchdown with a 3-yard run in the second quarter.
Kennedy was picked off by Sean Thomas on the game's opening drive, setting up
a 36-yard field goal from Stephen Brauchle that gave Louisiana an early 3-0
After an Arkansas State three-and-out, Harris extended Louisiana's ensuing
series with a 3-yard pickup on 4th-and-1 before capping the 12-play march with
a 3-yard TD run to make it 10-0 late in the first frame.
Harris added another 3-yard score on the Ragin' Cajuns' next sequence to
increase the margin before Rocky Hayes intercepted a Broadway pass later in
the quarter to set up Kennedy's 3-yard TD run that brought the Red Wolves
within 17-7 with 3:39 left in the half.
Brauchle buried a 38-yard field goal in the closing seconds of the half to
send the Ragin' Cajuns into the break with a 20-7 cushion.
Louisiana held Arkansas State's offense off the field for much of the third
quarter, limiting the Red Wolves to just four offensive plays in the frame.
The Ragin' Cajuns came up empty on a 14-play, half-opening drive after
Brauchle missed a 28-yard field goal, but the Louisiana place kicker made good
on a 30-yarder late in the quarter to make it 23-7.
Louisiana's defense made the lead stand from there, forcing the Red Wolves to
punt on their only two possessions of the fourth quarter before running the
final 8:54 off the game clock to secure the victory.
The Sports Network


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On Monday, about 20 of the borough's restaurants served a dozen cuisines, from Filipino kinilaw canapes to Himalayan yak dumplings.
A final set of responses to readers' questions about rice pot cooking and other issues.
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Ed Schneider's spicy corn stir fry tasted great. But the next time, char the corn first.
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The finer points of rice pot cooking, and some favorite food movies.
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1/2 cup milk (or more, depending on how much fish your cooking)
2 teaspoons salt
fresh or frozen fish fillets, completely thawed and drained
1/4 cup fine dry bread crumbs/per pound of fish
1/4 cup grated Parmesan cheese/per pound of fish
melted butter or butter flavored cooking spray
Preheat oven to 375° and butter your baking dish.
30 minutes before you're ready to start, blend together the milk and salt in a shallow bowl and soak fish.
In another bowl, combine bread crumbs, Parmesan cheese, and maybe a sprinkle of paprika.
Drain fish.
Roll fish fillets in crumb mixture.
Arrange in baking dish. Drizzle with a little melted butter or spritz top with cooking spray.
Bake 25 to 30 minutes, depending on thickness of fillets.
Fish should flake easily with a fork when done.
~ Use your favorite fish. Sole, Haddock, Talapia, Orange Roughy, Cod
~ For those of you who don't like a "fishy taste', soaking your fish in milk for 30 minutes draws out that fishy taste!
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