text:
Study Comparing Orteronel Plus Prednisone in Patients With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer
This study has been completed.
Millennium Pharmaceuticals, Inc.
Information provided by (Responsible Party):
Millennium Pharmaceuticals, Inc.
ClinicalTrials.gov Identifier:
First received: August 31, 2010
Last updated: March 4, 2016
Last verified: March 2016
- Full Text View
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- How to Read a Study Record
This is a randomized, double-blind, multicenter, phase 3 study evaluating orteronel (TAK-700) plus prednisone compared with placebo plus prednisone in the treatment of men with progressive, chemotherapy-naive, metastatic, castration-resistant prostate cancer (mCRPC)
Prostate Cancer
Drug: Orteronel + prednisone
Drug: Placebo + prednisone
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel Plus Prednisone With Placebo Plus Prednisone in Patients With Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer
Resource links provided by NLM:
Genetics Home Reference related topics: prostate cancer
MedlinePlus related topics: Cancer Prostate Cancer Steroids
Drug Information available for: PrednisoneU.S. FDA Resources
Further study details as provided by Millennium Pharmaceuticals, Inc.:
Primary Outcome Measures:
- Radiographic progression-free survival (rPFS) [ Time Frame: Day 1 to radiographic disease progression or death ] [ Designated as safety issue: No ]Time from randomization to radiographic disease progression or death from any cause, whichever occurs first
- Overall survival (OS) [ Time Frame: Time from date of patient randomization to the date of patient death due to any cause ] [ Designated as safety issue: No ]Overall survival
Secondary Outcome Measures:
- 50% prostate specific antigen (PSA) response at 12 weeks [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]50% PSA response at 12 weeks
- Changes in circulating tumor cell (CTC) counts [ Time Frame: 24 weeks ] [ Designated as safety issue: No ]Favorable changes in CTC levels at 24 weeks
- Time to pain progression [ Time Frame: From randomization to the end of treatment ] [ Designated as safety issue: No ]Time to pain progression as measured by worst pain item in the Brief Pain Inventory-Short Form (BPI-SF) and changes in opioid analgesic use, if any
|Study Start Date:
|October 2010
|Study Completion Date:
|March 2015
|Primary Completion Date:
|January 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Orteronel + prednisone
Drug: Orteronel + prednisone
Orteronel and prednisone will be administered orally twice a day continuously throughout the study. Patients will also receive concomitant gonadotropin-releasing hormone (GnRH) analogue therapy unless they have previously undergone orchiectomy and have a testosterone concentration of <50 ng/dL.
|Placebo Comparator: Placebo + prednisone
Drug: Placebo + prednisone
Placebo and prednisone will be administered orally twice a day continuously throughout the study. Additionally, all patients will receive concomitant gonadotropin-releasing hormone (GnRH) analogue therapy unless they have previously undergone orchiectomy and a testosterone concentration of <50 ng/dL.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Each patient must meet all of the following inclusion criteria:
- Voluntary written consent
- Male patients 18 years or older
- Histologically or cytologically confirmed diagnosis of prostate adenocarcinoma
- Radiograph-documented metastatic disease
- Progressive disease
- Prior surgical castration or concurrent use of an agent for medical castration
- Either absence of pain or pain not requiring use of any opioid or narcotic analgesia in the 2 weeks prior to study entry
- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
- Even if surgically sterilized, patients must practice effective barrier contraception during the entire study treatment and for 4 months after the last dose of study drug, OR abstain from heterosexual intercourse
- Meet screening laboratory values as specified in protocol
- Stable medical condition
Exclusion Criteria:
Patients meeting any of the following exclusion criteria are not to be enrolled in the study:
- Known hypersensitivity to orteronel, prednisone or gonadotropin-releasing hormone (GnRH) analogue
- Received prior therapy with orteronel, aminoglutethimide, ketoconazole or abiraterone
- Received antiandrogen therapy within 6 weeks for bicalutamide and 4 weeks for all others prior to first dose of study drug
- Continuous daily use of oral prednisone or oral dexamethasone for more than 14 days within 3 months prior to study
- Received prior chemotherapy for prostate cancer with exception of neoadjuvant/adjuvant therapy as part of initial primary treatment for local disease that was completed 2 or more years prior to screening
- Exposure to radioisotope therapy within 4 weeks of receiving first dose of study drug; exposure to external beam radiation within 2 weeks of start of screening until receiving the first dose of study drug
- Documented central nervous system metastases
- Treatment with any investigational compound within 30 days prior to first dose of study drug
- Current spinal cord compression, bilateral hydronephrosis or current bladder neck outlet obstruction
- Diagnosis or treatment of another malignancy within 2 years preceding first dose of study drug except nonmelanoma skin cancer or in situ malignancy completely resected
- Uncontrolled cardiovascular condition as specified in study protocol
- Known history of human immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C
- Unwilling or unable to comply with protocol
- Uncontrolled nausea, vomiting or diarrhea
- Known gastrointestinal disease or procedure that could interfere with oral absorption or tolerance of orteronel
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01193244
Show 245 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01193244
Show 245 Study Locations
Sponsors and Collaborators
Millennium Pharmaceuticals, Inc.
|Study Director:
|Medical Monitor
|Millennium Pharmaceuticals, Inc.
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on May 26, 2016
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Suri A, Chapel S, Lu C, Venkatakrishnan K. Physiologically based and population PK modeling in optimizing drug development: A predict-learn-confirm analysis. Clin Pharmacol Ther. 2015 Sep;98(3):336-44. doi: 10.1002/cpt.155. Epub 2015 Jul 14.
Saad F, Fizazi K, Jinga V, Efstathiou E, Fong PC, Hart LL, Jones R, McDermott R, Wirth M, Suzuki K, MacLean DB, Wang L, Akaza H, Nelson J, Scher HI, Dreicer R, Webb IJ, de Wit R; ELM-PC 4 investigators. Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial. Lancet Oncol. 2015 Mar;16(3):338-48. doi: 10.1016/S1470-2045(15)70027-6. Epub 2015 Feb 18.
|Responsible Party:
|Millennium Pharmaceuticals, Inc.
|ClinicalTrials.gov Identifier:
|NCT01193244 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 31, 2010
|Last Updated:
|March 4, 2016
|Health Authority:
|United States: Food and Drug Administration
European Union: European Medicines Agency
Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Diseases, Male
Genital Neoplasms, Male
Neoplasms by Site
Prostatic Diseases
Urogenital Neoplasms
Anti-Inflammatory Agents
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on May 26, 2016


text:
Bellingham, WA
Our mission is to build a bridge between concerned people in the West and children in the developing world, to help meet their spiritual and physical needs through a ministry that emphasizes education and is based on the Gospel of Jesus Christ.
Registered with eBay for Charity.
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on eBay and support your favorite causes!
Make a direct and immediate contribution through PayPal.
I want to support this charity by making a direct and immediate donation now.
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subset: commoncrawl


text:
The number of parents offering below $10 a week for allowance fell to 68.4% from 77.3% in 2011. On the flip side, 4% of families are giving their children between $41 to $50 per week. For a few lucky kids, there are the more than 1% of families that give between $91 to $100 per week.
Stuart Ritter, a senior financial planner with T. Rowe Price, who conducted the Parents, Kids & Money Survey. said there are a few reasons higher allowances are cropping up: a better economy and sharing financial decisions with kids, such as paying for their own clothes.
Additionally, older children are also to blame for allowance inflation, Ritter says. The more typical $5 won't get much for a 14-year-old these days.
Shelling out big bucks for your child's allowance might not be doing much good when it comes to teaching your kid financial responsibility, Lewis Mandell, the former management dean at SUNY, says.
When reviewing financial literacy tests, Mandell found that kids with unconditional allowances tended to do the worst. He suggests parents tie chores and allowance together to show that money is valued and earned.
Parents should also stick to their guns when little Johnny comes home crying that little Bob gets enough allowance to buy the entire class happy meals.
Remember, you're not a terrible parent if you only give your kid $10 a week in allowance, Mandell says.


text:
I'm new to this board here... sorry if the question has been asked a hundred times, but I didn't find any recent topics concerning this.
I have switched to Zimbra from google apps for your domain for various reasons and am very pleased with the online version of zimbra.
however on my main computer I use Zimbra desktop, mostly for the reason to get a local copy of everything, so in case my internet connection fails, I can at least still see my appointments and read old e-mails.
I don't know why, but neither the "Documents" nor the "Briefcase" is available in the Desktop version... the briefcase is one thing, and I could live without this... but documents would be rather important, as I use it to take business notes of various things, write e-mail templates and all of this.
any chances?


text:
BEA Account Code: H4022C0
For more information about this series, please see http://www.bea.gov/national/.
Source: US. Bureau of Economic Analysis
Release: Gross Domestic Product
US. Bureau of Economic Analysis,
Compensation of employees: Domestic private industries: Manufacturing: Durable goods: Motor vehicles and equipment [H4022C0A144NBEA],
retrieved from FRED,
Federal Reserve Bank of St. Louis
June 1, 2016.


text:
Custom travel with Vueling fares
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Miss Me Pieced Top
Sorry, this item is currently unavailable
Select styles are available for special orders. To check for special order availability, please submit your request below. We will process your request and notify you via email with the updated status of this item. Merchandise is not guaranteed. Shipping charges will apply with special orders.
The information you provide below is for this product request only. It will not be added to our marketing database.
- Beaded foil applique top
- 3/4 dolman chiffon sleeves
- Banded hem
- 65% Rayon, 35% Polyester.
- Machine wash with like colors inside out, gentle cycle. Do not bleach. Do not tumble dry. Lay flat to dry. No direct heat/chemicals on decoration.
- Made in China.
Have a Question?
- Body length 24" on size medium.
- Model Info: Height: 5'7" | Bust: 34" | Waist: 27" | Hip: 37" | Wearing Size: Medium


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Toronto, ON (Sports Network) - Rudy Gay scored 20 points and John Lucas III
added 19 in 19 1/2 minutes, as the Toronto Raptors pulled away from the New
Orleans Hornets in the fourth quarter to earn a 102-89 victory at Air Canada
Kyle Lowry recorded 14 points with 10 assists and Jonas Valanciunas chipped in
11 points and 10 rebounds for the balanced Raptors, who were coming off an
impressive overtime victory at Indiana on Friday.
Robin Lopez and Greivis Vasquez logged 19 and 17 points, respectively, as the
Hornets had their two-game win streak snapped.
The Sports Network


text:
Get into Tour-worthy shape with these core, flexibility and high-impact exercises.
Have a desk job? Don't do much more for fitness than ride your bike a few times a week? You're at high risk of developing back pain, obesity, diabetes and cancer. The average American spends 56 hours a week sitting, and even if you ride, that may not be enough.
The good news: Bicycling has the cure. Adding core, flexibility and high-impact exercises to your routine will help prevent the biomechanical imbalances common among cyclists, and will help keep you fit for life.


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Garmin USB Charging ClipItem #GAR134
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text:
Govern and Secure Big Data for the Enterprise
By Peter Jeffcock-Oracle on Jun 25, 2014
What if you could take the security of Oracle Database and extend it to Hadoop? You could get authentication of users, authorized access to data, and redaction of private information like passwords or personal data. You could even audit who did what and when.[Read More]


text:
See All Contributors »
Brain Drain: Most College Students Learn Next to Nothing, New Study Says
The report based on the book Academically Adrift: Limited Learning on College Campuses found that after two years of college, 45% of students learned little to nothing. After four years, 36% of students learned almost nothing.
http://finance.yahoo.com/tech-ticker/brain-drain-most-college-students-learn-next-to-nothing-new-study-says-535824.html?tickers=^GSPC,^SPY,COCO,APOL,DV,ESI,^DJI&sec=topStories&pos=8&asset= &ccode=
"We are first and foremost an educational institution that values integrity, honesty and treating others with fairness and respect".
-ISU President Gregory Geoffroy; circa May 2003.
You learn things but not much not much of what you learn can be used in the real world.
The gap in our economy is between what we have and what we think we ought to have--and that is a moral problem, not an economic one. - Paul Heyne
you learn how to work with people and how to pay your bills on time which are great life skills. That is why you have six months of training when you get hired out of school.
The one constant through all the years, Ray, has been baseball. America has rolled by like an army of steamrollers. It has been erased like a blackboard, rebuilt and erased again. But baseball has marked the time. This field, this game: it's a part of our past, Ray. It reminds of us of all that once was good and it could be again. Oh... people will come Ray. People will most definitely come.
I promise you engineering students learn plenty. This isn't news to anyone though, most of us are woefully unprepared for the real world.
I learned lots of stuff in college, much of which I've already forgotten. Most of which I'll likely never apply to anything I do in the real world.
Green hills for thy throne, and for crown a golden melody/Ringing in the hearts of all who bring thee love and loyalty/Dear Alma Mater, make our spirits great
True and valiant like the bells of I-O-WA STATE!
And thank you Stumpy for this:
College is great for obtaining information. Most of the time the information is useless for what you are really going to do in life.
Where college fails is in critical thinking! Most students show up to class, obtain information, accept as fact and move on. We do not learn critical thinking skills, we do not question our reality, we do not question the status quo, we are not independent thinkers and we live in our own little worlds.
All we do is obtain information and accept it for what it is. That is where college has failed us all.
I think I'm one of the minority that actually learned a lot in college.
I don't bring my own opinions, just attack others.
Not surprising. Like most things in life, you only get out what you put in.
That's what she said.
You learn more from a 6 month internship than you do in 2 years of college.
College is about survival of the fitest.
Originally Posted by cycoOJfan89
College is great for obtaining information. Most of the time the information is useless for what you are really going to do in life.
Where college fails is in critical thinking! Most students show up to class, obtain information, accept as fact and move on. We do not learn critical thinking skills, we do not question our reality, we do not question the status quo, we are not independent thinkers and we live in our own little worlds.
All we do is obtain information and accept it for what it is. That is where college has failed us all.
If there is one thing I've taken away from completing my English degree, it is the ability to think critically. Most of that critical thinking during college was applied to analyzing books, behavior, and ideas in general. While it may seem worthless to some to analyze Flannery O'Conner's Wiseblood, I have been able to apply the same skills to just about anything I do.
If you can come out of college with a good understanding of problem solving you are doing well, imho. You won't use most of the specifics you were taught, but you will use HOW to solve problems (how to approach them, use your resources, work in a team, etc.) every day. Loved this about engineering, but I'm sure you can get it with any major.
I've realized the most valuable thing I learned in college is how to use Microsoft Office. It's ridiculous how many people I can blow away with my simple Excel skills. Thank you Mechanical Engineering...
But honestly, I wish there were less classes. I flew through circuits & motors, instrumentation, and controls and hardly learned anything in ME370 and ME421. I would have rather taken 3 semesters to get circuits & motors down pat. The same goes for machine design. I learned what is capable of being calculated in that class, but I would have loved to go more in depth into everything. Very cool class. The thermo 1 and thermo 2 is set up well, but heat transfer just goes too fast to learn and RETAIN much information.
I'm looking forward to starting my masters. Working full time will make it tough, but it will be nice to just focus on one class at a time.
Shocking, if you are expecting to regurgitate most of what you learn into your job, go to a trade school, some place like ITT Tech. This is what they are there for.
Universities are there to lay the foundation for your future. Whether you continue in academia or go out and face the real world.
I'll probably never need to figure out the angular momentum of anything in my life, or know what two quarks in a meson are. But the skills I developed struggling with and solving those problems are what I'll use for the rest of my career.
College is not 100% just job training. It is the best time to take advantage of learning about History, Philosophy, etc. If all you want is job training go to Tech school. I enjoyed the classes I took in Drama and Classical Studies, even though I never intended to be an actor or professor.
Man suffers only because he takes seriously what the gods made for fun.
― Alan Wilson Watts
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STEUBENVILLE - Steve Daley has a simple recipe for success in the postseason - run the football and play good defense.
His Steubenville Catholic squad did both in Saturday's Ohio Division VII, Region 25 quarterfinal bout with Racine Southern at Harding Stadium.
The Crusaders racked up 182 yards on the ground while their defense caused four turnovers (one was a pick-6 by Khalil Jones) in scoring a 35-7 victory against the Tornadoes.
Article Photos
Khalil Jones
Steubenville Catholic, the region's fourth seed, earns a date next Saturday with top-seeded Glouster Trimble, a 63-0 winner against Beallsville. The location for the semifinal battle will be announced today by the Ohio High School Athletic Association.
Steubenville Catholic, making its 11th appearance in the playoffs, improves to 9-2 this season and 12-9 all-time in the Ohio tournament. Southern, a newcomer to the postseason, finishes at 8-3.
"That was a good team win," Daley said. "Do we like to throw it? Yes, but the plan going in was to test them on the outside, have them chase us a little bit, then try to hit the off-tackle inside. The kids executed what we planned out."
Southern, the region's fifth-seed, got on the board first, needing six plays to move 54 yards. Quarterback Tristen Wolfe hit Colton Walters on a slant route for an 8-yard touchdown.
"That was a little bit of us settling in," Daley said. "They didn't give us anything we hadn't seen out of them. We were not in position on a couple of plays but we got that corrected. Then, the defense stepped it up."
Steubenville Catholic quickly responded thanks to a 42-yard Jones return on the ensuing kickoff. Starting at the Southern 48, the Crusaders needed seven plays to score. Brenton Colabella drilled a 6-yard touchdown pass to Johnny DiCarlantonio, who was standing all alone in the corner of the end zone and John Paul McNamara nailed the conversion.
Steubenville Catholic's next touch ended in a punt and Southern took possession at its 38. On second-and-13, Jones intercepted a Wolfe pass and returned it 36 yards for the go-ahead score to make it 14-7.
Daley called Jones' pick "a turning point."
"It was huge," he added. "Making a play like that kind of got us going. That was a great play by him, it got our motor running and kind of jump started us."
Jones' defensive touchdown closed the first-half scoring.
Following a scoreless third quarter, Steubenville Catholic made it 21-7 early in the fourth, going 72 yards after Louis Fallon recovered a Tornadoes fumble. All but six of the yards came via the ground. Jones got the score on a 12-yard burst up the middle. He closely followed a huge Romano block through the hole and into the end zone
Another Southern fumble, caused by Fallon and recovered by Chris Murphy, led to the next Steubenville Catholic score. After a motion penalty and a yard loss on a rushing play, Colabella used play action before hitting Aleks Porreca on a go route. The senior wide receiver ran past the defender, caught the pass in full stride and crossed the goal. The pass and run covered 45 yards.
"Creating turnovers throughout the game was big," Daley noted. "They allowed us to get the ball back in the hands of our offense. We stayed the course on offense and did a great job of executing the plan."
Ryan Fletcher would stop the next Tornado drive with an interception.
The game's final score came via a 13-yard run by Jones. Jones paced Steubenville Catholic's ground attack with 101 yards on 11 carries. Fletcher added 56 on six totes and Murphy 26 on just two trips.
Colabella threw for 115 yards and two scores and Porreca finished with four catches.


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Re: How odd!
That sure is a curious plant. Has needles like a fir with new tips in orange red. It has red "flowers" at the ends of long white stems. Very curious indeed. I know where I will be for the next hour...
Looking at images on Google to see if I can solve this delicious mystery.
Thanks for the challenge!
My first thought was an Australian family of plants called Grevillea. There are dozens in the family and they have needled leaves and that red/orange color is very common in Grevillea.


text:
International Departure Hall check-in counters
(Check-in counters are closed punctually 45 minutes before scheduled departure time)
Cafés and restaurants available at the International Departure Hall
For further information, check the website of Chongqing Jiangbei International Airport.
International to International:
Minimum connection time 120 mins
Clear customs and proceed to international hall checkin counter
International to Domestic:
Minimum connection time 120 mins
Clear customs and proceed to domestic terminal
To city centre: Taxi: approximately RMB150
RMB90 (included in airfare)
Children under 12 are exempted
Passengers aged 18 or above are entitled to the following duty-free quota:
Tobacco Products: Hong Kong / Macau / China Residents: 200 sticks or equivalent of tobacco products
Overseas Chinese / Foreigners: 400 sticks or equivalent of tobacco products
Alcoholic Beverages: 1 bottle of alcoholic beverage. Alcoholic beverages are not allowed to be carried onboard as carry-on baggage except purchased at duty free shops in airport's restricted area.
Please note that all departing and arriving passengers are required to fill in a new customs and declaration form.


text:
JOCKEY ISAIAS ENRIQUEZ, MUSIC OF MY SOUL, WINNER: "He broke a little slow, but I was able to put him on the lead. After that, I'll I had to do was hang on. He was going so easy. He was just looking around and was so relaxed. I was playing cat-and-mouse with (Finallygotabentley) because he kept trying to move up and then I'd give my horse a little tap and he'd take off but then relax right away. In the stretch, my horse started moving side-to-side and was really getting tired. I'm just thinking, 'come on, lets go a little bit more, lets not lose this now, this is when I need you.' He straightened out and got it done."
JOCKEY LEONEL CAMACHO-FLORES, CARIBOO ROAD, FINISED SECOND; DECLARED NON-STARTER: "The horse broke before the bell and then when the gate opened, the (gate crewman) grabbed my horse. This was the first time I rode the horse, but I knew he was a good horse. He broke last, so I wasn't going to rush him. I started to ask him at the three-eighths pole and he really started to run. I think this is the best distance for him."
NOTES: Music of My Soul (7-3-2-0-$98,832)…Doris Harwood has a track-record 57 stakes wins at EmD and a record four wins in the Coca-Cola Handicap…Isaias Enriquez has two stakes wins at Emd (Jebrica, Budweiser Handicap; Music of My Soul, Coca-Cola Handicap)…Elttaes Stable (Ken Alhadeff, Seattle) has 11 stakes wins at EmD, tied with Billie Klokstad for No. 5 all-time at EmD…Next for 3-year-old colts & geldings: $50,000 Seattle Slew Handicap, 1 1/16 miles, Sunday, July 14.
JOCKEY ROCCO BOWEN, STOPSHOPPINGDEBBIE, WINNER: "It's easy riding horses for Tom (Wenzel) because we always come up with a game plan. We always have a Plan-B, but knock on wood, we never have to go back to our Plan-B. I was expecting someone else to go for the lead and push me, but they didn't and I really enjoyed that. At the five-eighths pole I saw that nobody was coming, so I knew they were going to have to use a lot of horse to catch up to me and even more horse to get by me. The breeding says it all. These kinds of horses are so classy. She's the kind of horse that runs push button. I'm still a little sore, but I'm doing OK. The only concern was that my leg was broken. The doctor said it wasn't, so I knew I was good to go."
NOTES: Stopshoppingdebbie (3-3-0-0-$64,818)…Northwest Farms has owned or co-owned five Irish Day winners including Stopshoppingdebbie and Elusive Noise (2011) in partnership with Debbie Paxton…Tom Wenzel has won four of the first seven stakes at the meeting, and ranks No. 7 all-time with 25 stakes wins @ EmD…This is the second straight time Wenzel and Northwest Farms have finished first, second and third in an EmD stakes. Stopshoppingdebbie, Goin to the Window and Blueberry Smoothie also finished first, second and third in the May 26 Seattle Handicap…Rocco Bowen has two stakes wins this year and five all-time at Emerald Downs…In her stakes wins this year, Stopshoppingdebbie has tied the stakes record with a 1:14.41 for 6 ½ furlongs in the Seattle Handicap, and broke the stakes record with a 1:34.74 in the Irish Day Handicap…Next for 3-year-old fillies: $50,000 Kent Handicap, 1 1/16 miles, Sunday, July 14.


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getting board members to fundraise
New Webinar: Leading Difficult Conversations with Donors, Board and Staff
There comes a time at every nonprofit when a difficult conversation must happen. A conversation, which if avoided, could really cripple the organization and its work. It could be saying "No" to a donor who wants to take the organization away from its mission, or telling a board member they need to start performing, or being honest with a staff member who is not a good fit for their position.
Because nonprofits are so resource-constrained it is critical that they put every resource to its highest and best use. And in order to do that, sometimes you must lead a difficult conversation.
The Social Velocity On Demand webinar "Leading Difficult Conversations with Funders, Board Members and Employees" will give you the tools to approach those conversations with confidence and skill so that you can do what's best for your nonprofit.
Some of the scenarios covered include when:
- A board member is not raising money
- A donor wants to launch a program that doesn't fit your strategy or mission
- A board member should be asked to resign
- A staff member is not performing effectively
This webinar will give you:
- Concrete language to use with funders, board members, staff
- A strategy to best approach a challenging negotiation
- Case studies and examples of difficult situations
- A process for thinking through future scenarios and focusing on what's best for your nonprofit
- A forum for putting your toughest situations to the test
- The opportunity to hear what challenges other nonprofit leaders face
Leading Difficult Conversations with Funders, Board Members and Employees
The registration fee will get you:
- A link to a recording of the webinar, which you can watch as many times as you like
- The PowerPoint slides from the webinar
- The ability to ask additional follow-up questions after the webinar
So if you struggle with telling donors, board members and staff what they need to hear, try our on demand webinar.
And if you want to learn how to create an overall financing plan for your nonprofit, join us for that webinar on April 24th. Click here to register
Photo Credit: www.geograph.org.uk
- Download a free Financing
Not Fundraising e-book
when you sign up for email
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Sign Up Here
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Learn how to create it
in the step-by-step guide.


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Greensboro, NC -- A Greensboro man is recovering at a hospital Saturday after another man shot him Friday night, police say.
Officers responded to the scene at 1516 Dorsey St. in Greensboro around 11 p.m.
The victim told police he got into a fight with the suspect in the street. During the fight, the suspect pulled out a gun and shot him, according to the police report.
The man ran from the scene toward Center Street.
EMS transported the victim to a hospital with non-life-threatening injuries.
Police are still investigating this shooting.
Anyone with information on this incident should call Greensboro police at 336-574-3573 or Crime Stoppers at 336-373-1000.


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Ford Cobra 427 Small Block Swap - Swapping Big For LittleWritten by on September 4, 2012 Ford Cobra 427 Small-Block - Part 1 of 2
Have you ever heard the saying "there is no replacement for displacement"? Well, to build power and torque without high compression or forced induction you have to go bigger. By bigger I mean larger stroke and bore that will increase the displacement, and if done right, push you back in the seat.
We started with a stock Ford 390 big-block that was lacking the oomph to push our test vehicle to its limits. We took the truck over to a chassis dyno to see what the old stock 390 was putting to the ground. The stock-ish 390 pumped out 240 horsepower and 290 torque at the wheels, but it was nothing to brag about since the motor is so heavy. Let me give you something to think about, if truck No. 1 has 400 horsepower and torque, and truck No. 2 has the same power and torque, but is 200 pounds heavier, what truck will get down the quarter mile first?
Let's just pretend that there are no other variables like reaction times, transmission, tires, etc. Most likely truck No. 1 would win because the power to weight was better. Still following me? Good. Since this particular truck does a lot of autocross, it was on the scales to adjust suspension, but more importantly we knew what it weighed before we removed the 390. In the end we were able to remove 200 pounds off the truck's front end and increase the power to weight.
So why replace a big-block with something that is physically smaller in size? Won't that have less power? Well, our 351W might have started out on the smaller side, but Ford beefed up the Windsor by increasing the displacement to 427 and the truck doesn't know if it is a small- or big-block, it only knows how heavy the motor is, along with the torque curve. The stock 390ci is 4.05-inch bore x 3.784-inch stroke, and the small-block 427ci is 4.125-inch bore x 4.00-inch stroke. So why does that matter? Usually the bigger the motor is in displacement (not actual size), the more power it will make, and more importantly, more torque.
For guys with heavy trucks, the more torque the better, as long as the horsepower is near the torque specs. In most cases, torque has the ability to get a heavy vehicle moving quicker from a dead stop than a same-sized motor with more horsepower and less torque. Remember the old saying, "horsepower sell cars, but torque wins races"; well, this is especially true for trucks that tend to weigh more than the average hot rod car.
A well-balanced engine, like our 450hp/520 torque Ford 427, will accelerate our '67 Ford F-100 and was a perfect choice for several reasons. One, Ford now offers a two-year/12,000-mile warranty on all its create engines. Two, we didn't spend six months searching for parts and waiting for machine shops to build it.
More Photos From This Article View Slideshow
The carb was removed and the throttle linkage was tied up behind the master cylinder. I also removed the oil pressure line that goes to the gauge.I used an adjustable engine load leveler from Harbor Freight to support the motor, as we were getting ready to remove the transmission bolts.The next step was to remove the torque converter bolts connecting the transmission to the engine. If you forget this step and somehow manage to pull out the torque converter, more than likely have 7 quarts sitting on the garage floor and a bent front pump. Don't forget to support the transmission with a jack or blocks of wood.We removed the bolts that hold the transmission bell housing to the engine. Then the engine hoist was raised slightly to put a slight pressure on the engine mounts so that the engine would not fall down. The mounts were then removed and the engine was free.My good friend Ed Kajioka helped guide the motor out while watched for things we forgot to disconnect.The motor is out. Now what? Well since the truck is split 50/50 between street driver and autocross, we started looking at how far we could move the 427 back in the engine bay.
Our test truck is pretty simple being that it has a weld-on Fatman Fabrication IFS suspension that replaced the factory twin I-beams. Notice where the old engine mounts were located on the Fatman crossmember and the boxed factory frame. We will be replacing the lower mount with a new lower mount from Fatman Fabrications.We ended up modifying these Speedway Motors mounts to push the motor even farther back. One thing to watch out for is where the oil filter comes out of the block. In a previous CT article we installed a Hamburger remote oil filter that allowed us to clear the modified mounts.We removed the pilot bearing that shipped with our Ford 427 so that our AOD's torque converter would fit inside the crank.The Ford 427 engine was temporarily placed in the engine bay so that we could adapt the motor mounts from Speedway and Fatman. Here, our test driver Scott Call lends a hand installing the motor.We used pieces of metal to help space the motor away from the crossmember and rack. We didn't let the full weight of the motor rest on these metal pieces, but rather something to stabilize the motor from moving on the engine hoist.We supported the engine from below with wood blocks, so that we could move the chains to the front of the engine only. This helped us move the front of the engine from side to side to square it in the engine bay.The Fatman lower engine mounts were then trimmed down to fit our application. Now we need to adapt the Speedway Motors engine mounts to the frame mounts.I crawled inside the engine bay with a permanent marker and lined up the engine mount tabs with the other mounts.
I removed the Speedway Motors inner sleeve on the motor mount. This acted as a spacer to hold the tabs during welding. I also used a few washers to help with installing and removing the motor.We measured the engine again to double-check if it was centered. Then the passenger side mount was tack welded in. We didn't finish-weld the mounts yet because, you guessed it, the motor was in the way. But we did make sure the mounts would not move when removing the motor.I have to say that this little Miller 211 does a great job of welding thick steel. This was one pass with 0.30 wire using CO2 mix. Not my first choice in wire size, but it worked good using the suggested settings.The owner of the truck wanted to make the engine bay to look nice again, so we removed the motor so that I could also finish-weld the new mounts. Here, Rob Mckeown sprayed the modified Speedway Motor engine mounts.Scott Call, the guy who drives the truck in the autocross, was also helping out with the whole build. Scott used aluminum foil and tape to mask off the framerails. He then painted the framerails as best he could to match the rest of the frame.Rob Mckeown and Pike Kelly prepped the engine block for a fresh coat of gray paint. We were all teasing Rob for changing the factory Ford Blue color, but in the end it turned out way better than I thought it would.I like to use gray silicone to seal V-8 intakes, and on the Ford small-block you need to use a lot of it.
Since Ford has the distributor in the front of the engine, you can build oil pressure in or out of the truck/ We tape a 1/4 extension on a socket that fit our Ford oil pump. We also removed the valve covers so that we could see the oil reach every rocker.A cordless drill will work for a little bit, but you may be better off with a larger electric drill. Make sure all your oil lines are connected and the oil pressure switch is on or this step will send oil everywhere. We attached the drill and spun it counterclockwise to build oil pressure in the motor. Then we made sure all the rockers had a good flow of oil running out the top. If for some reason you don't get oil flow to all of the rockers, slowly turn the motor over by hand and continue until all rockers are flowing.Before stabbing the motor in, make sure the torque converter is all the way in the front pump. Simply move it back and forth until it seats and spins free.We tried fitting several sets of headers, but the only ones that fit our pushed-back engine were Doug's Headers (part number D6648Y) in raw. We ran out of time to have them coated, but we will be finishing the headers and the other exhaust pieces later.


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ATLANTA -- You may have seen her hit TV show "Say Yes to the Dress: Atlanta" on TLC or heard of her popular Atlanta bridal boutique Bridals by Lori.
Lori Allen is now sharing a very personal part of her life to help save the lives of others.
She talked to 11Alive's Karyn Greer about her battle against breast cancer and the medical test she almost cancelled that saved her life.
RELATED | Behind the Scenes: "Say Yes to the Dress Atlanta"
MORE | Bridal trends, tips from Monte Durham


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Things to see and do - Atlanta
Leaving for USA
Atlanta :
Unmissable tourist sites
Where to sleep?
Atlanta Hotel tips
Holiday Inn Express & Suites - Atlanta Downtown from116 $Book
Courtyard by Marriott Atlanta Downtown from103 $Book
Hampton Inn & Suites Atlanta-Downtown from106 $Book
Atlanta Leisure tips
- 41.0 €
- Book
Private Departure Transfer: Hotel to Atlanta International Airport
- 12.0 €
- Book
- 76.0 €
- Book
Atlanta Travel guide
Atlanta : Michelin's recommendations
The commercial center of the American Southeast, Atlanta sprawls atop a high granite ridge against a leafy backdrop of wooded hills. From its gleaming downtown skyscrapers to the pricey boutiques of the ritzy Buckhead enclave, contemporary Atlanta serves up a smorgasbord of cultural, entertainment, shopping and dining opportunities. Turner Field, built in the heart of town to accommodate track events of the 1996 Summer Olympic Games, is now home to the Atlanta Braves baseball team. In Midtown you'll find myriad facilities housing the city's renowned arts organizations, including Atlanta Symphony Hall, the Alliance Theatre and the High Museum of Art.
Tourist attractions Atlanta : Things to see and do
USA - Atlanta, GA 30303
Downtown Atlanta, commercial nexus of Georgia and the Southern US, is home to soaring office towers.
Underground Atlanta
50 Upper Alabama St.. Downtown USA - Atlanta, GA 30303
This thriving mix of street vendors, retail outlets, entertainment and dining facilities occupies the site of the city's birth. As Atlanta grew as a railroad center, the ground level became congested with tracks. To accommodate street traffic, viaduc..
New World of Coca-Cola
55 Martin Luther King Jr. Dr.. Downtown USA - Atlanta, GA
This boxy series of pavilions is a tribute to the world's best-selling soft drink, born in Atlanta in 1886. Displays here trace the Coca-Cola story from its humble beginnings at a downtown Atlanta drug store to its multinational presence today. There..
Hotels Atlanta
Hampton Inn & Suites Atlanta-Downtown
161 Ted Turner Driver NW USA - Atlanta GA 30303
In the center of downtown Atlanta, this hotel is 5 blocks from the Cable News Network world headquarters. The hotel features a gym, free Wi-Fi and a hot breakfast. At the Hampton Inn & Suites Atlanta-Downtown, the rooms include a coffee maker and ca..
Courtyard by Marriott Atlanta Downtown
133 Carnegie Way USA - Atlanta GA 30303
Located in Atlanta city centre and less than 10 minutes' walk from Centennial Olympic Park, this hotel features an on-site bistro. Free Wi-Fi is provided in every room. A flat-screen TV and a refrigerator are found in each modern room at Courtyard b..
Glenn Hotel, Autograph Collection, A Marriott Luxury & Lifestyle Hotel
110 Marietta Street Northwest USA - Atlanta GA 30303
Prix Prices from : 124 $
Located in downtown Atlanta, this luxury hotel is within walking distance of CNN Studio Center and Georgia Aquarium. It features an on-site restaurant and spacious rooms with an iPod docking station. Glenn Hotel of the Marriott Autograph Collection ..
Leisure activities Atlanta
Prices from : 12 €
Skip the stress and confusion of finding a taxi upon arrival at Atlanta's busy international airport. Instead, book a great-value private car in advance and enjoy convenient, affordable and reliable private transportation from Hartsfield Jackson Inte..
Prices from : 59 €
Experience Atlanta in a unique way on this film tour. Cruising through the city by comfortable coach, see filming sites from 'Driving Miss Daisy' and 'The Blind Side,' see where 'Gone with the Wind' premiered in 1939 and visit the shop that inspired ..
Avoid the stress and hassle of waiting for taxis or bus transfers to Atlanta's international airport. Instead, ensure peace of mind with a great-value private transfer from your Atlanta or Buckhead accommodation to Atlanta Hartsfield Jackson Internat..


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Explore destinations in Europe, Middle East and Far East Asia for luxury travel
Jumeirah Restaurants and Bars are renowned for their 5-Star quality food and creative cuisine, but most of all for choice.
Indulge in the ultimate journey of tranquility and experience the world's most luxurious spas in stunning locations.
Take advantage of the amazing offers available at Jumeirah Hotels and Resorts in Europe, the Middle East & Far East regions. Book online today.
Exclusive events deserve an exclusive address. Choose from exceptional destinations for venues that capture the ambience of your special event. Inspiring and innovative, our venues are fitted with the latest technology and state of the art facilities.
Jumeirah Sirius, Jumeirah's Recognition and Rewards Programme, has been created to offer you an exclusive membership that opens up a world of privileges. Available at every hotel, resort and residence around the world.
Entertainment surrounds Jumeirah Himalayas Hotel – it's actually attached to the Himalayas Centre. This hub of art and culture is a new icon in the city of Shanghai, uniting some of the region's most memorable attractions under one roof.
Besides the Himalayas, the city of Shanghai is setting the pace for the rest of China. This dynamic metropolis is a frontrunner in art, culture, fashion and technology, with each neighbourhood offering its own unique identity – from the traditional, right the way to the ultra-modern.
Whether you're inspired by architecture, history or shopping, Shanghai's vast array of activities makes it likely you'll be satisfied.


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Heart Failure Infusion Program
Jefferson Building, Suite 208
85 Jefferson Street
Hartford, CT 06102
Phone: 860-972-1212
Fax: 860-545-3269
Treatment is individually tailored to achieve euvolemia (the presence of the proper amount of blood in the body). Infusion therapy is given by specialized heart failure nurses over 2-3 hour sessions and repeated on multiple days as needed. The Heart Failure Infusion Program functions within a multifaceted heart failure management program consisting of specialized dietary and nursing care focused on patient education and support. It safely bridges patients from the hospital to the outpatient community preventing relapse and re-admission while allowing patients to stay in the comfort of their home.
Ongoing, intermittent reinforcement of Heart Failure Self Care by specialized nurses and dietitians in the Infusion Program facilitates compliance, patient satisfaction, and reduced admission to the hospital while improving patients' quality of life. Outpatient diuretic infusion prevents deconditioning while promoting peer social interaction and emotional support.
Physicians, please feel free to contact us at 860-972-1212 with any questions or regarding the evaluation of a specific patient


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I could easily detect M63 at lowest power of 17x, next to a shiny star of 9th magnitude. With each higher power, the view became more interesting but also more confusing. M63 displayed a tenuous and elongated halo which gradually brightened towards the core. The nucleus appeared much brighter again and definitely not stellar. It looked rather granular. The more time I spent at the eyepiece, the better I could reveal some mottling in the faint halo. It appeared to me that the halo was growing larger with the time. The mottling in the halo suggested that the core was surrounded by concentric oval rings, or was that an illusion?
The sketch was made at 100x.
Site : Bekkevoort, Belgium ( 51° N )
Date : May 26, 2009
Time : around 22.30 UT
Scope : Skywatcher 102/500mm achromatic refractor
Eyepiece : Baader Hyperion 5mm
Magnification : 100x
FOV: 41'
Filter : none
Seeing : 3/5
Transp. : 4/5
Sky brightness : 19.93 magnitudes per square arc second near zenith (SQM reading).
Nelm: 5.7
Sketch Orientation: N up, W right.
Digital sketch made with Corel Paint Shop Pro X2, based on a raw pencil sketch.


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That's a heck of a bear! Congrats to you
I've been sitting in a very cold treestand off and on all of April trying to kill a big spring bear with my bow but yesterday I had a change of heart. I had taken my old Winchester Model 94 into a gunsmith to get my new 2.5X Leupold Scout scope mount installed and it happened to be done late yesterday afternoon. After a quick dinner I ran out and got it dialed in at 100 yards. It only took ten shots and the last 3 were in the money but man that little sucker kicks!
I headed into a spot that's always seemed like a good place to try and call a bear in as I was tired of sitting and waiting and wanted to try and make something happen. I hadn't been calling for over a minute when I saw black movement off to my left at about 110 yards and I thought for sure he was coming in! Well he ended up sitting down on his haunches at around 100 yards and staring off in the direction of the sound. The problem was there was some brush blocking a clear shot so I called away trying to draw him closer to no avail. Finally about 30 minutes before dark I layed off the calling to see if he would move enough to present a shot and it worked perfect. He originally headed to cover and it looked like I wouldn't be getting a shot but he turned back to the left and walked out into the open and I finally saw just how big he was. Turned out my first guess was correct he was a pretty good bear! 6.5 feet long and around 400 pounds (just an estimate). I hit him perfect the first shot but since I was using my old level action I took another shot at him when he bolted but it wasn't neccesary as he only made it about 20 yards. The old 30-30 came thru with my longest shot ever on a bear.
I have to say I couldn't be happier with the Scout scope setup I went with on that old Winchester! I killed a few bucks with it back when I was 12 and 13 but it's been sitting in the closet for years as I'm not much for shooting with open sights and I could never stand the side mount scope set up I tried on it years ago.
Anyhow here he is.......
That's a heck of a bear! Congrats to you
Nice bear congrats!
That is a great looking bear! Nice work!
Nice bear thanks for sharing the story!
Shoot STR8
Very nice. Man that skull has some wide ears on it! That would have been a blast to hunt! Congrats.
I hunt because......
Great bear! Nice work on the pic as well.
Thanks guys. Most everything else in Oregon is going downhill but we do have some great bears. The way this guy came running at first I'm sure he's had his share of blacktail fawns and elk calves.
Nice butterball bear! Should be good eatin'
Live to hunt, hunt to live.


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Most of us are used to pampering the skin on our faces in an attempt to hold onto our youthful looks or erase the effects of time. We often overlook our hands even though it is the hands that often give our age away. June Jacobs Spa Hand Creams are designed to condition and nourish our tired and overworked hands. Even though our hands take a lot of abuse throughout an average day, we typically fail to treat them right. June Jacobs Spa Hand Creams are rich in moisturizers so even the driest, most irritated hands can find balance and comfort once again.
Because of constant exposure to the elements such as sun and dry wind, the hands can become dry, cracked, chapped and leathery. Over time, the hands experience wrinkles and spots just like the face does. Many people have said that if you want to know a woman's true age, just look at her hands. June Jacobs Spa Hand Creams help you keep your little secret by allowing your hands to feel and look just as young as your face does. Remember to treat your hands with the save love and care as you do the rest of your body. June Jacobs Spa Hand Creams make it easy to keep your most exposed parts in tip top shape.
Right before bedtime is a great time to pamper the hands since they won't be used for hours until you're ready to get up. Make sure to treat your hands with one of the June Jacobs Spa Hand Creams available. You'll wake to soft, nourished and comfortable hands.
Are your hands dry to the point of being uncomfortable? June Jacobs Peppermint Hand and Foot Therapy is a very effective moisturizing treatment product that can be used on both the feet and hands. This is a rejuvenating and stimulating cream that uses peppermint to stimulate tired and achy hands. Peppermint just also happens to be a natural antiseptic that keeps the hands clean and healthy. Nourishing oils from jojoba and sesame soften dry skin and relive the itching and discomfort associated with dehydration and tightness. The oils reach deep within the layers of the skin for long lasting protection against dryness. You can use the treatment anytime you need it.
June Jacobs Green Tea and Cucumber Revitalizing Hand and Foot Treatment is also a great cream that can be used on both the feet and the hands. The formula is rich with a blend of shea butter and olive oil. The cream also contains nourishing and protective vitamins that soften and condition. This is a very effective treatment for hands that are showing signs of aging. Even rough, dry skin can rediscover a smooth and soft texture with regular use of June Jacobs Green Tea and Cucumber Revitalizing Hand and Foot Treatment.


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We've got a couple of trade threads going successfully around the forums, so I'm starting one here too. This is the thread where you can offer up things for trade. You've got an item you don't need and you need something else? Trade it here. You need something and someone else has it? Trade it for something you've got here.
A few rules-
NO mention of money. This is a TRADE thread only. Any mention of money will get deleted.
NO advertising. This is not for store owners or people who own some type of store and want to get their stuff out there. Any advertising will be deleted.
ALL trades need to be done via PM. Any conflicts do not involve bikeforums or its agents. Trader beware!
ONLY bike related items are to be traded here. Anything else offered up for trade by either party will be deleted.
There will probably be other guidelines we'll add on. Check back with this first post for any updates. If we see repeated violations, we'll just close out the thread if it gets out of control.
Trade on!
Koffee Brown
Forum Moderator


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Jon was four-year regular with the men's basketball teams
at Butler from 1995-98 and helped lead Butler to back-to-back NCAA
Tournament appearances in his final two seasons. He was a twice
named first team all-league and was named Midwestern Collegiate
Conference (now Horizon League) Player of the Year in 1997. The 6-6
forward was named Butler's Most Valuable Player in 1996-97
and he was selected as the MCC Tournament Most Valuable Player in
Jon led the Bulldogs in scoring for three straight seasons, 1996-1998, and he is the only player in Butler men's basketball history to lead the team in rebounding for four consecutive seasons. He finished his career with 1,485 points, which ranks 10th on Butler's all-time scoring list, and 719 rebounds, which ranks sixth on the school's all-time rebounding chart.


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MASCOUTAH, Ill. (AP) - The federal government won't make a decision for years on whether to close Scott Air Force Base, but leaders in southwest Illinois fear growing budget pressures in Washington could affect the facility's future.
The Belleville News-Democrat reports Illinois congressmen are working to keep the base open even though the next round of base closures won't take place until at least 2015.
Republican U.S. Rep. John Shimkus tells the newspaper that the base's fate is at risk if Congress doesn't reform entitlement programs. Defense Department officials have said that the facility has more infrastructure than needed.
Civilian workers at the base near Mascoutah are already scheduled to start taking 20 days of unpaid furloughs between May and September as a result of a series of automatic federal budget cuts.
Information from: Belleville News-Democrat
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Nudo Italia: Olive Oil from Your Own Tree
Store Profile
- Location: online only
- Specialty: Italian olive tree adoptions and products
- Price range: ($) Budget - ($$) Mid-Range
- Website: nudo-italia.com
Store History
- Founded: 2005
- Founded by: Jason Gibb and Cathy Rogers
- Headquarters: La Marche, Italy
Jason Gibb and Cathy Rogers set up Nudo in 2005 after buying and restoring an abandoned 21 acre olive grove in Italy's Le Marche. Their love of the Italian countryside inspired their now famous Adopt an olive tree programme which allows people all over the world to adopt an Italian olive tree and receive its oil. A love of simple natural food is the starting point for all Nudo products. They are all made from 100% natural, high quality, locally sourced ingredients.
Under the Tuscan Sun had you simultaneously searching for your passport and googling Italian farmhouses for sale. Now you can indulge your ex-pat dreams of living la bella vita without leaving the country. Own a piece of the La Marche countryside and reap the benefits of your personal olive tree's harvest with Nudo.
Adoption, of the olive tree variety, is simple and rewarding. Pick your tree (or let Nudo do it for you) and pay the fee. For less than what it costs for some exclusive oils we've seen out there, Nudo sends you 3 packages: a nifty adoption certificate and details of your new, delicious baby; a harvest shipment with an average of 2 liters of cold-pressed extra virgin olive oil; and a spring shipment with flavored oils ranging from chili to mandarin. If you're the hands-on type, Nudo invites you to come to the grove and visit your tree any time. Not ready to be an olive tree parent? You can still order the delicious bounty from the grove via their store, including not only olive oil but condiments, spreads, pasta, and gift adoptions for foodie friends that will love you forever.
• Daily Find: Nudo Extra Virgin First Cold Press Olive Oil
Images: Nudo Italia.


text:
Speaker Wenming Ye
Duration 01:02:39
Date recorded 4 December 2013
Virtual machines (VMs) provide an easy way to move and run your applications and services in the cloud. Microsoft Azure supports both Linux and Windows virtual machines in a portable and scalable way. The Gallery allows users to quickly choose and deploy a wide variety of pre-configured VMs. At the VMDepot the community can upload and share Linux VMs from scientific applications--from Biolinux, iPython and Data Science, to web content management systems such as Drupal and CKAN. Once deployed, VMs allow scaling out of applications across tens or hundreds of nodes. Through programmatic control of VMs through the Microsoft Azure SDKs in Python, Java, .NET, and other languages researchers can design and build custom applications to provision and manage VMs on demand, dynamically.
Areas covered in the session:
©2013 Microsoft Corporation. All rights reserved.
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My Chief meets THE Chief today
Tiffany Winman 12000065XB firstname.lastname@example.com | | Tags:  it green obama stimulus intelligence grids smarter energy ibm healthcare smart infrastructure planet palmisano economy education
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Social media and Barack's inauguration
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Today was a very special historic event for the United States and the world as we swore in Barack Obama as our new president. The excitement not only filled Washington DC, but rocked the social media universe as well. What social media strategist wouldn't be caught up in the excitement ... [ + Read more ]
Re: Get Back to the Future
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In response to: Get Back to the FutureJen, when I click on the Agenda builder link, I get an error. However, this link works: https://www-950.ibm.com/events/global/pulse/pulse2009Agenda/?wm=7112001f4343&cm_sp=CTA02-_-SWK00-_-4343 ... [ + Read more ]


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Jay Z, Kanye West, Beyoncé, Rihanna, and Chris Brown are among the musicians named in a bizarre $2.4 billion civil rights lawsuit filed by a prisoner in a California jail.
Richard J. Dupree, Jr. is convinced the musicians stole lyrics for over 3,000 songs he wrote while serving time behind bars, by spying on him via satellite with the aid of several law enforcement agencies, including the Central intelligence Agency, the Federal Bureau of Investigation and Homeland Security, according to Re-Tox.com.
It is not clear which songs Dupree is claiming feature his lyrics, but in the lawsuit, which he filed on April 21 in California Eastern District Court, he is asking for damages and to be freed from California State Prison, Corcoran immediately.


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WASHINGTON – IPhones and iPads are cool, but they don't compare to the gadgets of the well-heeled.
The Harry Winston Opus 12 watch tells the time without pesky minute or hour hands. Wired.com reports this 18-karat white gold wristwatch has blue metal arms that look like daggers. You can own this timepiece for the low price of your home: It costs $260,000.
Forget the iPhone. The Vertu takes the smartphone to the next level. The device has a concierge service that gets you into exclusive clubs, makes travel bookings and orders the finest wines. The Vertu sells for $13,800.
This toilet truly deserves being called a "throne." Named Numi, Kohler's newest innovation in relief costs more than $6,000 — but comes with some exciting features. Numi has adjustable, heated seats, opens when approached and offers a touchscreen interface.
To see more expensive gadgets, on Wired's website.
Watch the Numi in action:
WTOP's Veronica Robinson and Lacey Mason contributed to this report. Follow Veronica and WTOP on Twitter.
(Copyright 2012 by WTOP. All Rights Reserved.)
Sure, you could grill another hot dog. Or, you could try one of these 30 recipes for foods you never knew you could cook on the grill.


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Trey Hillman Media Session: May 13
Royals' Manager Trey Hillman met with the media prior to this afternoon's game.
Hillman was asked about the health of catcher Jason Kendall:
Kendall's forearm was x-rayed during last night's rain delay and the results came back negative. Kendall would not react to the contusion after being hit by a pitch last night and declined to be taken out of the game. Hillman was impressed by Kendall's gritty toughness, but made the decision to hold him out of today's lineup.
Hillman also commented on pitcher Blake Wood who made his Major League debut last night:
Hillman is dead-set on keeping Wood in the bullpen; stating the he assessed the young right-hander during Spring Training and that he has the perfect mental make-up to be a successful reliever. When the team broke Spring Training for Opening Day, Hillman was strongly considering Wood for one of the bullpen spots. Had it not been for some forearm issues slowing down Wood, Hillman believes he likely would have broken with the Major League club.
Hillman finished by talking briefly about today's starting pitcher Zack Greinke:
Hillman thinks that Greinke will be comfortable with today's starting catcher Brayan Pena. Pena caught Greinke a few times last season, developing a positive rapport between the two. Hillman continued by addressing the lack of offensive contribution during Greinke's starts this year. A major reason behind the lack of run support is due to hitters putting added pressure on themselves to score runs for the ace pitcher, especially coming of the Cy Young Award.


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Most people dream their whole lives of even a single mention in the pages of The New Yorker, and our longtime friend and partner Aida Batlle earned a 12-page profile in the current November 21 issue – fittingly the annual Food Issue, with articles about some of the culinary world's most interesting trends and innovative developments. Congrats, Aida!
Titled "Sacred Grounds – A revolution in coffee," the article by New Yorker staff writer Kelefa Sanneh chronicles Aida's meteoric rise in the coffee world – from when she first took over her family's farmland in El Salvador to her first Cup of Excellence competition, subsequent stardom, and present day, hands-on collaboration with Counter Culture and a select few other roasters.
Products of an unmatched dedication to quality, all of Aida's coffees are special and precious. This year, we are grateful to offer fresh lots from Finca Mauritania (including a Natural Sundried lot), as well as Cascara – dried coffee fruit to be steeped like tea – from all four of her farms. And our most special coffee, by far, is Aida's Grand Reserve, which this year was crafted from only the peaberries from each of her farms, processed using a variety of techniques learned from Indonesia, Kenya, Sumatra, and Brazil.
Please join us in congratulating Aida and celebrating her wonderful coffee.


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Out of Stock
Item # MRP0021
Don't worry though, we have a lot more Chain Guides & Bash Guards in stock than that.View Similar Products
MRP G2 SL Chain Guide $0.00
When it comes to chain retention, guides can add unwanted weight to your all-mountain or enduro race machine. Thankfully, though, the MRP G2 SL Chain Guide is aimed squarely at the rider who needs to keep weight down, but can't afford a dropped chain.
MRP uses a 5mm thick piece of CNC'd aluminum for the G2 SL's boomerang. It's expertly machined with reliefs to drop any extra heft from the design. For bash protection, MRP chose to use a polycarbonate skid plate that's replaceable for long-term use. Three-points of attachment ensure that the skid plate and boomerang form a strong structure for trail abuse.
A redesigned derailleur-cage-style upper guide fully encloses the chain, and a lower pulley wheel with sealed bearings prevent any chance of the chain coming off of the chainring. The guide is also simple to setup, due to its front access and single-bolt positioning of the upper guide.
The MRP G2 SL Chain Guide is compatible with 36-40 tooth rings and comes in the color Black.


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(AP) -- Researchers are testing the remains of a humpback whale that washed ashore in central Florida for contaminants.
A boater spotted the estimated 40-foot-long humpback whale carcass Wednesday in Canaveral National Seashore.
Researchers from the Hubbs-SeaWorld Research Institute have been collecting organs and bones spread across the beach, including 18-inch-wide vertebrae. The bulk of the whale's carcass was left in a remote area to wash back out to sea.
Research assistant Teresa Mazza tells Florida Today that the whale likely died about a week ago.
Humpback whales are an endangered species. Mazza says the remains were too decomposed to help researchers determine what caused the whale's death, but she also says researchers haven't found anything unusual.
Mazza says a couple humpback whale carcasses wash ashore in central Florida each year.
Associated Press


text: I have a 2005 Honda Rincon and absolutely love it! I have not done anything to it but a battery and a set of tires. I think I have close to 6000 miles on it. It has by far been the best bike i've owned. The only down fall is the tranny, a little high geared but the motor makes up for it in power. Comfortable, easy steering in and out of 4x4 without power steering, good ground clearance but not top heavy like the grizzlys. I have riden a couple of others and would still prefer mine over the others. I am tempted to look into the arctic cats. They are one of the few that offer a 500 class with independent suspension and fuel injection. We are a Yamaha family which have been good bikes to but i still like the honda more, like i said it has a couple downfalls but overall and all around its great!


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Golden Gait Trailers is open Monday-Friday from 8:00am-6:00pm and Saturday from 9:00am-3:00pm. (Our Rental Department is closed on Saturdays.)
We at GGT offer trailers parts, rv parts, trailer sales both new and used as well as service for all your trailer and RV needs. We have a large selection of trailers, trailer parts, RVs, parts and accessories in stock. From utility trailers, car haulers, cargo trailers, dump trailers, trailer hitches, trailer accessories and trailer brakes.
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For a grand and tranquil getaway, a road trip north from California's Bodega Bay is a shore thing.
In 1961, while scouting locations for his movie The Birds, director Alfred Hitchcock came on the village of Bodega Bay in Sonoma County an hour north of San Francisco. Hitchcock loved the quiet and the misty atmosphere–but not the cheery weather on the day he started shooting. Leave it to the Master of Suspense to find the dark side of sunny skies.
Forecasting the weather remains a winter guessing game on the Sonoma coast. More predictable is the wild drama of the earth. On unhurried outings up Highway 1 from Bodega Bay to the border with Mendocino County, travelers pass rough terrain that feels like the threshold to another world. It's a landscape laced with quiet trails to wild, windswept beaches where rock formations rise like medieval ruins. Restaurants, inns, and shops crop up unexpectedly along the 50-mile drive, but commerce takes a backseat here: While slurping oysters on a deck, diners pause as the sun slips into the Pacific; strollers stop along a path to peer at a pod of migrating gray whales.
A fine stop on the way to this compelling shore is the tiny hamlet of Valley Ford, on Highway 1 just south of Bodega Bay. At the pioneer-era Valley Ford Hotel, Brandon Guenther and Shona Campbell run Rocker Oysterfeller's Kitchen and Saloon. Their Southern-inflected menu—molasses-braised pork shoulder, fried organic chicken— is well attuned to contemporary currents, but the pair also pays homage to the past. Antique seltzer bottles line the walls, and Campbell playfully labels herself a "bar wench" as she mixes highbrow drinks.
"We know we're not that far from the city," Guenther says, "but sometimes it can feel like the frontier."
Seven miles west in Bodega Bay, the coast pops into view. Although taffy houses and a winetasting spot dot the roadside, this town remains at heart a working port. Battered fishing boats bob beside salty-dog restaurants. Spud Point Crab Company serves chunky clam chowder rich with garlic and cream, as well as sweet Dungeness crab in tangy sandwiches or simply cracked. A tip for gourmands: Local crab season opens in mid-November.
The road north from the harbor curls alongside Sonoma Coast State Beach, a 17-mile expanse that is not one beach but a string of them, only some visible from Highway 1. Several can be reached by the Sonoma Coast Trail, which cuts over the bluffs to craggy outcrops and hidden coves. Goat Rock Beach, near Jenner, where the Russian River ends its journey to the sea, offers a wide swath of sand sweet for strolling.
Winter skies here are dramatic, if often rainy, just as they were in the early 1800s when Russian traders founded Fort Ross. A stockade, chapel, and barracks today grace a state park with ample exhibits on the settlers' early struggles.
Up the highway, a 72-foot-tall metal column erected in 1969 by sculptor Beniamino Bufano announces Timber Cove Inn, a stone-and-redwood lodge that recently underwent a $2.5 million remodel. Rooms, most with ocean views, fireplaces, and spa tubs, promise comfort and seclusion, while paths along the bluffs are ideal for sunset rambles.
In the hour-plus it takes to reach the county's north shore, the main draw is the splendid isolation. Pine-shrouded Salt Point State Park–where visitors are free to hunt wild mushrooms in the rainy season—merges into the Sea Ranch, a strand of carefully spaced shingled homes interrupted by lanes leading to rocky overlooks and five public beaches. Just north, Gualala Point affords a view of the town of Gualala. For many travelers, hitting the county line is a cue to put the ocean on their right and head back south.
Bodega Bay's Tides Wharf Restaurant, which enjoyed a cameo in The Birds, showcases photographs of actress Tippi Hedren under assault by murderous flocks. At Bodega Head, a nearby promontory and great whale-watching spot, their feathered relatives wheel and cry. But the birds are only bit players in this show—the coast itself is the star.
Photography by Melissa Barnes [3]
This article was first published in November 2009. Some facts may have aged gracelessly. Please call ahead to verify information.
Request the Northern California & Nevada TourBook and Mendocino & Sonoma Coast map at AAA.com [4] or any AAA branch office. Contact the Sonoma County Tourism Bureau at (800) 576-6662 or visit sonomacounty.com [5]. Area code is 707.
Alexander's Seasonal cuisine in a bluff-top dining room. 21780 Hwy. 1, Timber Cove, 847-3231, timbercoveinn.com [6]. Annapolis Winery Open daily noon–5 p.m. Free tastings, tranquil picnic grounds. 26055 Soda Springs Rd., Annapolis, 886-5460, annapoliswinery.com [7]. Bodega Bay Lodge & Spa All 84 rooms have ocean views. 103 Hwy. 1, Bodega Bay, 875-3525, bodegabaylodge.com [8]. Fort Ross State Historic Park 19005 Hwy. 1, 847-3286. River's End Refined dishes, impressive sunset views. 11048 Hwy. 1, Jenner, 865-2484, ilovesunsets.com [9]. Spud Point Crab Company 1860 Westshore Rd., Bodega Bay, 875-9472, spudpointcrab.com [10]. Stillwater Cove Regional Park Scenic 210-acre park with trails and beach access. 22455 Hwy. 1, 847-3245, sonoma-county.org/parks/pk_stwtr.htm [11]. Timber Cove Inn Rustic relaxation. 21780 Hwy. 1, Timber Cove, 847-3231, timbercoveinn.com [6]. Twofish Baking Company Irresistible morning buns. 35590 Verdant View, Sea Ranch, 785-2443, twofishbakery.com [12].


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Our free and open Jörðgarð (TM) RPG campaign setting is right on target with its planned release for this year. We already have signed off on a large number of maps, dungeon plans, etc. that are used in the Jörðgarð books. Some folks who have been in contact with us have asked for an advanced release of the maps so that they can use them in their own non-Jörðgarð RPG campaigns. These maps were created with Fractal Mapper (TM) 8 and exported as JPG flat maps. Starting today, we'll release one map every week. The first map for this week is of the western hemisphere of the campaign world, known as the Jörð. You can get it in any one of three versions:
1. A JPG flat map, 1360 x 1055 pixels, with location names. To get this map, go to the Jörðgarð web site at the link below ( 1 MB)
2. A JPG flat map, 1360 x 1055 pixels, without location names. Use the image above (1 MB)
3. The original FM8 map in FMP format, fully editable. Download it from our Jörðgarð web page (32 MB). This version includes a PDF pamphlet that tells you how to use the layers and multi-zoom functions that are built into the map.
All three versions are released for personal and commercial use under the Open Game License Version 1.0a, which you can read on the Jörðgarð web site.
The Jörðgarð web site:
Next Week: The Continent of Ása before the Great Wars