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Stem Cell-Mediated Oncocidal Gene Therapy of Glioblastoma (GBM)
Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites. Despite advances in surgical, radiation, pharmacologic, and gene therapies, survival with a BT remains dismal. Current therapies are limited by their inability to reach widely disseminated tumor cells that become dispersed within normal brain structures. Interestingly, the therapeutic property that is needed to overcome this major obstacle to effective treatment of BTs matches well with one of the better accepted attributes of neural stem cells (NSCs): an attraction for sites of pathology in the adult brain, including primary & metastatic cancer. If armed with a proper tumor-killing gene, NSCs (whether administered into the brain or into the bloodstream), that are drawn to cancers, will dramatically reduce tumor burden, and will track after even single migrating tumor cells. The NSCs perform this action without themselves becoming tumorigenic or augmenting the pre-existing tumor, and this can be assured by having NSCs express a suicide gene that can be activated and cause NSCs to die. The tumor homing phenomenon of NSCs was first revealed by researchers on this proposed team and, in fact, the central concepts presented here have since been extended to many other kinds of disease. In this proposal, we will use a number of authentic mouse models of primary BTs to pre-clinically test therapeutic NSCs. Human NSCs (hNSCs) will be derived from 3 distinct sources, with each having been proffered as therapeutic, but never having been compared head-to-head in treating tumors. Each of these hNSCs will be modified using two therapeutic genes: TRAIL, which is a protein that specifically kills tumor cells, but does not harm normal cells and tissues, and cytosine deaminase which converts a non-toxic chemical into a toxic chemotherapeutic. We expect our research to identify the best hNSC + therapeutic gene combination to advance for clinical trial in patients with BTs, following our obtaining regulatory approval for using hNSC therapy at the end of this project. Because immunocompatibility of the hNSCs with recipient patients is not a concern in BT therapy, a limited number of hNSC lines can be used for treating all prospective patients. Furthermore, BT treatment does not require long-term NSC survival and can be combined with commonly used BT therapies. Finally, NSCs can be imaged in patients and therefore monitored after administration. Developing this approach for treatment of BT patients offers an ideal setting and opportunity for achieving dramatic results from stem cell therapy, and the results of this project will likely be applicable to the treatment of other cancers.
Brain tumors (BTs) are incurable, whether they start in the brain or spread there from other sites. Despite advances in surgical, radiation, drug, & gene therapies, survival with a BT is extremely short, because current therapies are limited by their inability to reach tumor cells that spread widely to normal brain structures. Interestingly, the therapeutic property that is needed to overcome this major treatment obstacle matches well with one of the better accepted attributes of neural stem cells (NSCs): an attraction for sites of disease in the adult brain, including primary & metastatic cancer. If engineered to be armed with a tumor-killing gene, NSCs (whether administered into the brain or into the bloodstream), that are attracted to cancers, could dramatically reduce patient tumor burden, and track after even single migrating tumor cells, in a manner that has never been achieved. The NSCs would perform this action without themselves causing tumors or increasing growth of the patient's tumor, and this would be assured by engineering the NSCs to self-destruct. The tumor homing phenomenon of NSCs was first revealed by researchers on this proposed team and, in fact, the central concepts presented here have since been extended to many other kinds of disease. In this proposal, we will use a number of authentic mouse models of primary BTs to test therapeutic NSCs before testing them in humans. Human NSCs (hNSCs) will be derived from 3 distinct sources, with each having been proposed as therapeutic, but never having been compared head-to-head in treating cancer. Each of these stem cells will be modified using two different therapeutic genes: TRAIL, a protein that specifically kills tumor cells, but does not harm normal cells and tissues, and cytosine deaminase, which converts a non-toxic chemical into a chemotherapy drug that kills the tumor. We expect our research to identify the best hNSC + therapeutic gene combination to advance for evaluation in clinical trials in patients with intracranial BTs, after we have performed all necessary animal safety testing and submitted a complete plan for review by the US FDA and NIH. Members of this proposed team have experience in bringing cancer therapies to clinical trial, hold the IP surrounding the use of stem cells against cancer, have begun discussions with the FDA and NIH, and have enlisted a GMP facility. Because immune system compatibility between donor and recipient of the hNSCs with the recipient is not a concern in BT therapy, a small number of donors could be used to produce genetically modified hNSCs to treat all prospective patients. Developing this approach for treatment of BTs offers an ideal setting and opportunity for achieving dramatic results from stem cell therapy, and accomplishing substantial improvements in quantity and quality of life for BT patients would no doubt increase California's worldwide visibility in offering the best possible medical care for cancer patients.
During the first year of this project we have made substantial progress toward achieving the ultimate goal of developing a stem cell (SC) therapy for treating patients with recurrent glioblastoma (GBM). At the outset, we began investigating three SC candidates as the cellular vehicle to carry a therapeutic payload and disperse within the tumor of GBM patients: mesenchymal stem cells (MSCs); fetal neural stem cells (fNSCs); and adult neural stem cells (aNSCs). In addition, we were considering two therapeutic genes as the payload, cytosine deaminase (CD) and tumor necrosis factor related apoptosis-inducing ligand (TRAIL), and two routes of therapeutic SC administration for treating brain tumor patients, intravascular and direct intratumoral. Thus, at the start of the project, there were twelve possibilities (3 stem cell vehicles x 2 therapeutic genes x 2 routes of administration) to investigate and compare prior to determining the best combination to develop for a GBM clinical trial. From this starting point we have been able to rapidly eliminate the aNSCs from consideration due to their slow rate of proliferation that would limit their expansion to sufficient number for use in a clinical product for patients. Next we determined that SC access to intracranial tumor through intravascular injection was negligible, and that it is highly unlikely that SC administration by this route would result in a sufficient number of SCs reaching intracranial tumor for achieving therapeutic benefit in treating patients with recurrent GBM. Thus, our work to date has resulted in the narrowing options for SC + therapeutic gene + route of delivery to four: two cellular vehicle candidates (fNSCs and MSCs) and two therapeutic gene payloads (CD and TRAIL). During the first year of this project, each of the four combinations has been tested and have demonstrated anti-tumor activity. During early year 2 research we will determine the most effective combination based on preclinical testing results using multiple human GBM models. The decision regarding most effective therapeutic gene + stem cell vehicle will be achieved within six months, and from that point, in going forward, project emphasis will focus on the development of a specific product candidate, including manufacturing process and assay development, GLP/GMP product manufacturing, further preclinical animal studies to demonstrate efficacy and safety, and development of a clinical protocol. In association with the research accomplished to date we have developed and applied several approaches that will prove useful for SC research and clinical application in general. Foremost among these is the use of micron-sized particles of iron oxide (MPIOs) for labeling SCs prior to their injection into animal subjects, and then monitoring the movement of labeled SCs using magnetic resonance imaging (MRI). This is a powerful technique with implications for understanding the distribution and persistence of SCs in patients receiving SC therapies. For our project, this method is informing us about the distribution of labeled SCs within and around brain tumors, as well as with regard to how long the SCs remain in animal subjects. In addition to the MRI detection of iron particle labeled SCs, we have developed and refined a technique for determining the amount of human SC DNA in animal subject tissues, which has a sensitivity of detecting one human cell among more than a million host cells. Similar to the MRI detection of labeled SCs, the DNA detection method provides us a very sensitive approach for monitoring SC biodistribution and persistence in animal subjects, and it is broadly applicable to all SC research in which rodent models are used for pre-clinical investigation of SCs for treating disease. We are also developing novel approaches for the use of optical imaging to visualize stem cells labeled with fluorescent reporters, and for monitoring the anti-tumor activity of therapeutic stem cells administered to animal subjects. These novel approaches are contributing to the repertoire of techniques available to expedite the identification and application of therapeutic SCs in clinical settings. This project is a collaboration among outstanding scientists and clinicians at five of California's leading medical research institutions: the Sanford-Burnham and Salk Institutes in La Jolla, and the San Francisco, Los Angeles, and San Diego campuses of the University of California (including Ludwig Institute at UCSD). By leveraging complementary expertise of these investigators, we have made rapid progress in the preclinical animal studies, design of the clinical trial protocol, and the product development studies that will lead to preparation of a gene-modified SC product for the clinical trial. These activities will culminate in an IND application to FDA that will allow us to test the safety and efficacy of our SC product in patients with this devastating illness.
This project was initiated in April of 2010, and was for comparing
• three types of stem cells
• two distinct therapeutic gene modifications of stem cells, and
• intravascular administration vs. direct tumor injection of stem cells
in order to identify the most efficacious stem cell + therapeutic gene + route of administration for treating patients with recurrent glioblastoma (GBM), a brain tumor that has a dismal prognosis, and that badly needs innovative approaches for improving treatment outcomes.
Major conclusions from this project, as concerns the objectives indicated above, are:
1. Stem cells administered by the vascular route do not reach brain tumors established in rodent subjects, to an extent which demonstrable therapeutic stem cell anti-tumor activity should be anticipated. In most instances, intravascular administration results in no detectable stem cells in intracranial tumor in rodent models. Therefore, therapeutic stem cells need to be administered direct into brain tumors in order to achieve a sufficient number and concentration of stem cells for observing anti-tumor effect.
2. Neural stem cells and mesenchymal stem cells delivered directly into intracranial tumor display similar extents of dispersion in tumor, indicating these stem cell types should perform comparably as concerns their ability to disseminate within, and deliver therapy to tumor.
3. However, unmodified (non-immortalized) neural stem cells, derived from single adult or fetal sources, have insufficient proliferative capacity for production as therapeutic stem cells to be used in clinical trials that enroll multiple patients. Because of the ready availability of mesenchymal stem cells (MSCs), from many donors, combined with the proliferative capacity of MSCs, MSCs were determined as the preferred candidate for developing therapeutic stem cells to treat patients with recurrent GBM.
4. Studies conducted with therapeutic stem cell + tumor cell mixtures indicated superior anti-tumor activity of cytosine deaminase modified stem cells + 5-fluorocytosine (FC), relative to secretable TRAIL modified stem cells, when anti-tumor activity is examined in liquid media (cell culture). The two types of therapeutic stem cells showed comparable anti-tumor activities when administered directly into brain tumor in animal (rodent) subjects.
5. In relation to other types of therapies (e.g., chemotherapeutics, antibodies, liposomal drugs) being tested by members of this disease team, manufactured therapeutic stem cells displayed low (modest) anti-tumor activity in animal subjects with brain tumor.
Technical advances, discovery, and products developed in association this project, and that can be shared/transferred in support of other CIRM funded research, include:
• Development of approaches for delivering stem cells through distinct routes of administration in rodent subjects.
• Development of a method, based on the use of polymerase chain reaction, for detecting human cells in rodent tissues, with a sensitivity of detection of one human cell per 100,000 mouse cells.
• Development of a cell labeling approach that enables tracking of stem cell migration in rodent subjects.
• Development of a histochemical method for detection of labeled human cells in rodent tissues.
• Development and characterization of multiple, tumorigenic human glioblastoma xenograft models for use in therapeutic testing.


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University of Wisconsin Stout | Wisconsin's Polytechnic University
Inspiring Environment
We offer a wide variety of foods and venues for your dining pleasure.
We offer a wide variety of foods and venues for your dining pleasure.
UDS offers many dining venues to meet your needs. All-you-can-eat cafeteria dining is available at North Point and Commons. Quick grab-and-go is available across campus at Jarvis Express, Price Commons and North Point Mini-Marts, Fireside Cafe, Blue Devil Market, and University Library Express.
For your convenience you can find the regular business hours to the right among our quick links.
*note: Harvey Hall is currently closed for renovation.

subset: commoncrawl


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|Prospect, Ky.
|High School:
|Sacred Heart
* 2011 Horizon League All-Tournament Team
* 2010 1st Team All-Horizon League
* 2010 Horizon League Newcomer of the Year
* Atlantic 10 Commissioner's Honor Roll
* Butler Athletic Director's Honor Roll
2012 - Junior Season: Battled through injuries to come off the bench in 11 contests...scored one goal on nine shots...had four tries on goal...tried three shots vs. UT-Martin (Sept. 2)...scored goal at 89:56 to help Butler earn a tie at Richmond (Oct. 12)...had a shot on goal at Charlotte (Oct. 28)...put her lone shot on goal in league tourney vs. La Salle (Nov. 2).
2011 - Sophomore Season: Voted to 2011 Horizon League Women's Soccer Championship All-Tournament Team...named to all-tournament team at Kentucky...started 12 of 17 matches and finished third on the team in goals (3) and points (6)...totaled 15 shots and one game-winning goal on the year...had an assist and two shots on goal in win over Madonna (Aug. 19)...scored a goal and added an assist in win over Eastern Michigan (Sept. 2)...tallied an assist at Eastern Illinois (Sep. 4)...scored a goal and had two shots in win at Oakland (Sept. 16)...scored a goal and totaled a season-best three shots vs. Xavier (Sept. 29).
2010 - Freshman Season: Named Horizon League Newcomer of the Year...voted first team All-Horizon League and named to league's all-newcomer team...played in 19 matches, starting 17...ranked second on the team with 11 points...had three goals and five assists...scored two game-winning goals...totaled 20 shots, nine on goal...notched two assists in win over Miami (Ohio) (Sept. 3)...credited with an assist vs. Oregon (Sept. 19)...scored first career goal vs. Oakland (Sept. 24)...had three shots vs. Valparaiso (Oct. 3)...scored a goal and took four shots at Green Bay (Oct. 8)...assisted on game-winner at Milwaukee (Oct. 10)...had an assist vs. Loyola (Oct. 15)...fired three shots on goal against Cleveland State (Oct. 24)...scored game-winning goal in league tourney semifinal vs. Detroit (Nov. 5).
High School: 2009 Kentucky Miss Soccer and ESPN Gatorade Player of the Year...voted Kentucky Farm Bureau Female Athlete of the Year...named all-state and all-district three times...four-year starter and two year team captain...named to state tournament all-tourney team during junior and senior seasons...led Sacred Heart to three consecutive state championships...team went 57-6-8 during three state title seasons...high school coach was Chris Moore...led club team Mockingbird Valley to three state championships...honor roll student and National Honor Society member.
Personal: Born Aug. 14, 1992...daughter of Carl and Tricia Hafele...twin sister, Nikki, plays soccer for Butler...exploratory business major.


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David Jarvis
Senior Consultant, IBM Center for Applied Insights
The IBM CAI blog has moved - please bookmark and follow the new blog at http://www.ibmcai.com
In a world of increasing and varying information security threats, academic initiatives focused on cybersecurity are proliferating - yet, there is still the danger of falling short in addressing the long-term threat. To avoid becoming too focused on near-term issues, programs must be more collaborative across their own institutions, with industry, government, and among the global academic community. Only by working in concert can we meet today's demand while educating the next generation to create a more secure future.
There have been a lot of recent reports, blog posts and news articles discussing the cybersecurity skills gap. It has been an ongoing issue for a while, and will continue into the future. We wanted to tackle this problem, not from the demand side, but from the supply side. So, the IBM Center for Applied Insights and IBM's Cyber Security Innovation team selected 15 academic programs in 6 different countries from the over 200 institutions we monitor and work with. We conducted interviews with faculty members, department chairs and others. This week, we released a synthesis of those interviews in our latest security insights paper, "Cybersecurity education for the next generation: Advancing a collaborative approach" .
Through our interviews it was confirmed that cybersecurity is top of mind for students, educators, industry and government. Industry and government are currently facing a significant skills gap and this is causing the programs we interviewed see extremely high demand for their students, both undergraduate and graduate.
But, not all is rosy with the increased demand and attention. Programs are expected to provide more of everything – courses, graduates, opportunities, research – which has caused programs to face a number of organizational and technology challenges. Stained programs are addressing these challenges in different ways, taking different approaches to cybersecurity education, but still sharing similar common principles.
The trends, challenges, issues and differing perspectives cannot be fully addressed by each academic program on its own; cybersecurity is a global problem and should have global solutions. A set of leading practices promoting a longer-term and more collaborative approach is needed. We identified three general areas that the leading programs we talked to excelled at, all dealing with collaboration and connection.
1. Collaborate within your own institution – Cybersecurity programs should embed security practices and principles in computer science and engineering courses and take a holistic technical approach. They should work with other disciplines and schools in the university (e.g., business, law, ethics, medicine, policy). They should offer diverse education options for students and professionals (graduate, undergraduate, professional development, etc.).
2. Co-evolve with industry and government – Academic programs should have deep ties with industry and government – partnering and collaborating on research, curriculum development, and opportunities for students. A hands-on, practical, approach is also extremely important. Laboratory work, projects, special-interest groups, and internships should all be cultivated.
3. Connect across the global academic community – A number of the programs we talked with discussed the need for building a "science of security" to anticipate security problems and a cross-discipline lingua franca among scientists, engineers and policy makers. Fundamental concepts and common vocabulary can only be developed with participation of the entire global cybersecurity community.
To read more about leading cybersecurity education practices, case studies, and IBM's recommendations, download our report . The paper is part of our ongoing security insights series which includes the 2012 IBM CISO Assessment and the Security Essentials for CIOs series.


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Webs sheathed in a thin veneer of frost appear as if encrusted in tiny diamonds. This free theme for Windows harkens the arrival of winter.
A theme is a combination of desktop background pictures, window colors, and sounds. All of the images will be downloaded when you click Download theme.
This theme can only be used in Windows 10, Windows 8.1, Windows 8, Windows RT 8.1, Windows RT, and in Windows 7 Home Premium, Professional, Enterprise, or Ultimate editions.


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Set in the beautiful Tuscan countryside, Mugello is one of two circuits owned by Ferrari - the other being Fiorano.
The fast curves and rapid changes of direction render Mugello an ideal track for aerodynamic and other tests; at Fiorano, the mechanics and brakes are only gently worked. Along its 5 245 metre length, drivers have to negotiate fifteen curves, nine of them right-hand.
These right turns are particularly important in evaluating the balance of the chassis and can reveal the real limits of a vehicle. Mugello is a circuit where a mix of straights, fast and slow 'Ss', ascents and descents, and scorching slopes oblige the driver to stay concentrated throughout. (The stretch leading into Scarperia has a 9.5% slope.) One of the most exciting but technically difficult sections is the Casanova alla Scarperia curve.
Here, the driver has to have a perfect line, otherwise one mistake is amplified going into the following curve, rather like the way in which Maggotts and Becketts run into each other at Silverstone. The line through Casanova should lead to the best position to tackle the Savelli curve, and from this point into Arrabiata 1 and 2; two rights to be taken as one. The rather wide track allows the driver a number of racing lines and offers many overtaking points.


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Love it! That purple against the grey is so cool!
Thanks! This one one of my favorite color combos. Glad you like it.
Sweet color combo! Love the teacup with the grimace : )
Awesome designs would you like to submit your designs to a limited edition Tee company in New Zealand
email me for more info firstname.lastname@example.com
email me for more info email@example.com
So cute!
Very beautiful
i also found a great message with a simple drawing is the best art ever! check out mine! see if we can sync!! http://society6.com/product/break-is-...
See More Comments


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Our heroes
Here we profile some of IUCN's conservation heroes - people from Brazil to Pakistan, Laos to the Democratic Republic of Congo - all with unique stories to tell.
The Turtle Lady
Dr Fehmida Firdous – Pakistan
The efforts of Dr Fehmida Firdous, known as the 'Turtle Lady of Pakistan' to save marine turtles has earned accolade from the country's President and international media attention. …
03 May 2011 | News story
Never lose heart
Maryam Bibi - Pakistan
For almost two decades Maryam Bibi has battled against prejudice and intolerance to improve the lives of women and children in some of the world's poorest areas. …
28 Apr 2011 | News story
Sneezing in the rain
Ngwe Lwin - Myanmar
It may be more common these days to hear doom and gloom stories of biodiversity loss and environmental degradation, but exciting discoveries of new species do happen and give heart to conservationists the world over. …
11 Apr 2011 | News story
Winning hearts and minds
Lalao Aigrette - Madagascar
For decades, biologists have campaigned for marine reserves, struggling with the mistrust or disapproval of fishermen. Lalao Aigrette, a dedicated Malagasy conservationist, is taking on this challenge amongst remote fishing communities in some of the most biodiverse regions of Madagascar. And she's seeing some impressive results. …
11 Apr 2011 | News story
The power of partnership
Nigel Dudley and Sue Stolton 2011 – United Kingdom
Nobody knows better the benefits that national parks and other protected areas bring to people and nature than Sue Stolton and Nigel Dudley, and no one has worked harder to bring this knowledge to bear in saving the world's natural wealth. …
11 Apr 2011 | News story
Saving Singapore's green space
Dr Ho Hua Chew - Singapore
In Singapore, where space is tight, nature conservation faces some difficult odds. And no one is more familiar with the challenges than Dr Ho Hua Chew of IUCN Member organization the Singapore Nature Society who has fought for years for official recognition of the island state's wildlife. …
11 Apr 2011 | News story
Trapped in the Amazon!
Renata Leite Pitman - Brazil
"Ten years ago, moved by curiosity, I planned a three-month expedition to the south east of Peru to learn more about an elusive species, and maybe trap and radio collar it. Ten years later, I feel it was the animal that trapped me!," says Renata Leite Pitman. …
04 Apr 2011 | News story
A blessing in disguise
Tahir Qureshi – Pakistan
"In 1984, when I was a Divisional Forest Officer, I was kidnapped in the thick forest of Dadu, in southern Pakistan. The armed gang kept me in captivity for two nights but it seemed like a thousand years. My confidence was shattered and my career took a turn for what I thought at the time was the worst. After this, I decided to work on coastal conservation. This change, which involved restoring mangroves, was actually a blessing in disguise. It gave me a platform to chart completely unexplored territory in Pakistan." …
04 Apr 2011 | News story
Conservation for peace
Prudence Mazambi and Pascal Murhula Balezi, the Democratic Republic of Congo
In the Democratic Republic of Congo, despite the area's instability and prevalent violence, two young conservationists fight to protect the environment through comics, theatre performances, radio programmes and reforestation initiatives. …
04 Apr 2011 | News story
The man who saves turtles
Dr Nicolas Pilcher - Malaysia
Nick saves sea turtles. In a nutshell that's what he does. But he has to look far beyond their nesting grounds to make it work. …
04 Apr 2011 | News story


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Looking for more information about Robert Thomas McCarty?
Search through millions of records to find out more.
First Lieutenant in the U.S. Army Air Force during WWII. Uncle Bob co-piloted the B-17 Flying Fortress "Sugar Puss." He was shot down over Italy during his 50th bombing mission. After much determination, his widow Ruby Lee (Edson) McCarty Steele finally was able to secure all his war medals posthumously including the Purple Heart. Uncle Bob was my mother's only brother and my grandmother's only son. More documentation and photos to follow.
Search through millions of records to find out more.
Anyone can contribute to this page. Please sign in or sign up—it's free.


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First of all, really sorry to post and post. What are peoples opinions on installing a silencer to header pipe. The new silencer pipes diameter is the same as the header pipes diameter. I read somewhere that Ace used some aluminium roof flashing and clamps to connect. Sounds like a pretty good idea to me and im pretty sure i should be able to get it pretty tight. Should be alright. He said he like this over using putty which can be messy. Ive also decided i wanna paint the new silencer matt black and use a black exhaust tape to cover the header pipe. Mainly for the look because i will need to cover up the clamps, aluminium and the hook that the old heat shield attached to.
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text: Dianna Agron got an unpleasant surprise as she returned to her car in Studio City this afternoon. The 'Glee' star was carrying her adorable French Bulldog puppy and a canvas tote bag on her way out of a friend's house when she discovered the parking ticket for an expired meter. July 17, 2013.


text:
Meal Type
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Substitute 1/4 cup chopped fresh cilantro for the onions.
This easy-to-make Asian-inspired low-calorie, low-fat meal is as delicious as takeout. And as a bonus, the combination of broccoli and red peppers not only provides vitamin A and but it's also high in vitamin C.
* Nutrition information is estimated based on the ingredients and cooking instructions as described in each recipe and is intended to be used for informational purposes only. Please note that nutrition details may vary based on methods of preparation, origin and freshness of ingredients used.
Bland! I used chicken instead and seasoned/ marinated it well and we still needed to use soy sauce!


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Mark Henry injured
For those of you that might not have noticed, Mark Henry was not utilized by WWE for the entire month of December. That has led to some questions about his status within the company, especially since he was forced to lose so quickly during the Survivor Series main event. The rumors floated around enough that Henry himself has decided to respond via social media. The former world heavyweight champion explained that he was simply injured.
December 30, 2014


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New Orleans, LA (Sports Network) - Stephen Curry canned six 3-pointers en
route to a game-high 30 points and the Golden State Warriors dominated the
fourth quarter to take a 93-72 victory against the New Orleans Hornets.
The Warriors, who recently had lost nine of their last 10 road games, won
their second straight away from home by holding the Hornets to just 11 fourth
quarter points.
David Lee chipped in a double-double with 20 points and 11 rebounds and Klay
Thompson contributed 13 points in the victory.
Ryan Anderson had a team-leading 21 points to go with nine rebounds in New
Orleans' third defeat to the Warriors this season. Losers in 11 of 14 games
overall, Anthony Davis scored 16 and Greivis Vasquez notched 14 points with
nine assists.
The Sports Network


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A Century of Refractory Standards
ASTM International Committee C08 Contemplates Past, Present and Future
The term "refractory" is defined in C71, Terminology Relating to Refractories, as "nonmetallic materials having those chemical and physical properties that make them applicable for structures, or as components of systems, that are exposed to environments about 1000˚F (538˚C)."
In other words, if you can't stand the heat, you're not a refractory.
C71, along with more than 70 other standards, was developed by ASTM International Committee C08 on Refractories, which is celebrating its 100th anniversary this year. ASTM Committee C08 was founded in 1914 to develop standards for refractory materials, which are used to build a various structures that are routinely subjected to high temperatures.
"I believe that C08 has made significant contributions to the refractories industry through its long history," says Samuel Bonsall, research associate, advanced refractories division, Vesuvius, Bettsville, Ohio, and current chairman of C08. "The standards developed in this committee have defined what a refractory is, classified them by type and function and defined key test methods to determine their suitability for a given application."
In the early decades of C08's existence, refractories would have been used to build the linings of fireplaces, stills and kilns, among other applications. The astonishing technological advances of the 20th century expanded the use of refractories to include the linings of nuclear reactors and the reentry heat shields for space shuttles.
"At C08's beginning, which could also be equated to the beginning of the modern era of refractories, there were no standard methods available to evaluate supposedly equivalent materials," says Leonard Krietz, vice president, research and development, Plibrico Co. LLC, Chicago, Ill., currently chairman of C08's awards subcommittee. "With the coming of standardized tests, manufacturers and consumers had the tools to benchmark a refractory's performance to a test result. This enabled the means to evaluate and develop new materials in the lab for improved performance in actual application."
Some of the key standards developed by C08 include:
- C20, Test Methods for Apparent Porosity, Water Absorption, Apparent Specific Gravity, and Bulk Density of Burned Refractory Brick and Shapes by Boiling Water;
- C357, Test Method for Bulk Density of Granular Refractory Materials; and
- C862, Practice for Preparing Refractory Concrete Specimens by Casting.
Bonsall notes that C704/C704M, Test Method for Abrasion Resistance of Refractory Materials at Room Temperature, has also emerged as an important C08 standard.
"C704 has had a huge impact on the petroleum processing industry in defining suitable refractories," says Bonsall. "Efforts in the committee have been directed to reducing the variability of the test method as well as developing a new, more severe test for extremely abrasion resistant materials, in recognition of the ongoing improvements in refractories."
On the future of the committee, Bonsall says, "C08 has managed to survive the last 30 or so of globalization of the world economy and the consolidation and restructuring of major users of refractories such as the steel industry. My hope is that we can generate new interest and appreciation for the work of Committee C08."
Committee C08 will celebrate their 100th anniversary on March 26, during the March 25-26 C08 meetings to be held in St. Louis, Mo., in conjunction with the St. Louis section of the American Ceramic Society. For more information on the March meetings and celebration, contact Kathleen McClung, manager, ASTM (phone: 610-832-9717).


text:
You limited your search to:
Partner: The Dolph Briscoe Center for American History
Decade: 1830-1839
Serial/Series Title: National Intelligencer
Collection: Texas Digital Newspaper Program
National Intelligencer. (Houston, Tex.), Vol. 2, Ed. 1, Thursday, June 20, 1839
Date: June 20, 1839
Creator: unknown
Description: Weekly newspaper from the Houston, Texas area that includes local, state and national news along with extensive advertising.
Contributing Partner: The Dolph Briscoe Center for American History


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Showing their form days before the start of the Red Bull X-Alps on July 19 in Salzburg, Thomas de Dorlodot (BE), Ramon Morrilas (ES) and Pál Takáts (HU) finished first, second and third respectively at the El Yelmo Festival Mountain Race in Andalucia, Spain on 4 July.
Consisting of an 11km mountain run with a height gain of 800m, followed by a short flight with one turnpoint, the trio trounced the field, which consisted of a number of pro-runners.
"It was great to have the three Red Bull X-Alps pilot at the goal," said Thomas. "We realised that the training for the Red Bull X-Alps has paid off."
Check out more details in the Athletes' Diary section or on Thomas' blog: http://thomasdedorlodot.blogspot.com


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Roasted Pairings; Ethiopia Vs. Kenya
Our final pre-holiday roast session is a head-to-head battle: which is the brightest, most dynamic, sweetest, most attractive coffee in Africa. How do the clean, vivid wet-process Ethiopia coffees stack up against the ripe fruit-bomb Kenyas? For this I chose the latest arrivals, both stellar wet-process lots: Ethiopia Organic Wet-Process Kebado and Kenya Auction Lot 738 -Marua Peaberry. Both roasts were quite light to maximize the intensity of the bright end of the spectrum. Ethiopia was roasted to a mere 420f using a slow warm-up profile with first crack ending at 415 or so. I think we can call this a true City roast, and a good one at that, with no bready or grainy light roast flavors. Marua had less mositure content and was roasted carefully to 380, temperature dropped to ensure entering 1st crack slowly, and finished at 426f, a City-City+ roast. Interestingly, the Kebado is one of our vacuum-pack projects, shipped in boxes from Ethiopia. It definitely had more mositure in the coffee and needed more time in the early part of the roast, whereas Kenya is a typical jute (well, sisal in this case) coffee, shipped in fiber bags. I noted that the Kenya 1st crack was at 398, a little early, and Ethiopia Kebado was at 406f. Since cross-origin cuppings are something I do nearly every day, the interesting differences in these 2 lots isn't as dramatic to me; what strikes me in cupping these side by side is how wonderfully aromatic they BOTH are. Kebado's citric and floral aromas are stunning; Marua fills the nose with ripe, red fruits, slightly winey in character. It's interesting to compare the Ethiopia's Meyer Lemon sweetness, with a slight rindy accent, to the slightly deeper tonality of the Kenya fruits. In general, I feel the Kebado is closer to perfection (in the review I call it a competition-winning type coffee), but these are definitely 2 very, very special lots, and I hope they spark some commentary, and inspire a few holiday smiles in your world... -Tom


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Apex Tricep/Bicep Super Curl Bar
Item # 3889305
|Members of The League get 5% back when you spend $100! (see promotion details)
Product Details
Tone your arms with a little help from the Apex® triceps/biceps curl bar. It isolates and intensifies development of the biceps, triceps and forearm muscles, and includes 2 safety spin locks.
- Apex� triceps/biceps curl bar
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- Includes 2 safety spin locks
- 2-year manufacturer's limited warranty
Assembled Dimensions: 47" x 4" x 3"
Product Recommendations
Product Reviews
Reviewed by 1 customer
- Comfortable
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Best Uses
- Body Building
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- Sports Training
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Comments about Impex Apex Tricep/Bicep Super Curl Bar:
Best product for your buck.
- Was this a gift?:
- No


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Growing up z
Can it really be 30 years since I began my career fresh out of college as a COBOL programmer? After a short stint as an applications programmer I moved into the Systems Programming field in the early days of MVS (for you newbies that was several generations before z/OS). I saw the revolution that was MVS/XA and then MVS/ESA and the large scale changes to the computing environment brought about by the improvements in each of these new releases of the operating system.
This blog isn't as much about the improvements in technology. While that is very interesting and probably warrants coverage in a future blog, this entry is largely about my musings about the last 30 years. No, I'm not going to give year by year coverage. I'd bore myself to tears writing it and I'm sure readers would not expend the effort to read it. However, it is interesting to me to consider the skills that were required of me and my peers and to wonder are those skills that are still being taught.
Will there be a next generation of Sysprogs? Will skills like REXX, SMP/E and my all time favorite Assembler programming diminish in the work place and just go away. If they don't go away, will the younger folks find these skills as fun and challenging or are they more enamored with web GUI'S and other such pretty innovations? Will sub second response for things like TSO and CICS be in demand or pretty pictures and 5-10 second response from a web console?
Better yet, will there be a demand for old guys like me? Maybe I can retire and then double dip and do some free lance Assembler programming!! I'd be interested to hear from other Sysprogs, both younger and older. How do you see the field shaping up in the future?


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You are a fan of show comments ? Come to discover the best forums show comments on the internet and share your experience with a community fan of show comments . You can also build a forum show comments and create your online discussion.
Sleuthing and Spoilers A site for fans of The Bachelor & Bachelorette who enjoy sleuthing and discussing spoilers for this show and others!
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A dedicated, community forum for pet and show fancy mouse owners. Share pictures and discuss breeding, environment, health, nutrition/diet and behavior.
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Free forum : No, we are not based on the tv show, Supernatural, however we are a group centered around supernatural beings, such as werewolves, vampires, etc. . .
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Cheme Designs: Fun, Eco-Friendly Furniture for Kids
Store Profile
- Location: Online
- Specialty: Kids' furniture
- Price range: ($$) Mid-Range
- Website: chemedesigns.com
Store History
- Founded: 2011
- Headquarters: North Carolina
At Cheme Designs, we believe in play. It is in this belief that we offer a line of furniture that is inspired by kids, the masters of play. Our goal is to offer original designs that are enticing to kids, appealing to adults, and safe for us and the environment. And we are proud to say, that our entire process (design, build, and ship) is done here, in the USA.
When the makers behind Cheme Designs went to find a water table for their own boys in 2003, they just couldn't find anything they liked. An idea was planted, and a table of their own creation was born — and then eight years later, their own line of kids' furniture (that happens to be both environmentally and style friendly!) followed.
These curvy, modern designs are made from solid wood and furniture-grade plywood, and best of all — have no sharp corners! All stains and paints are low- or no-VOC; their colorful stools, desks, and tables are painted with kid-friendly milk paint or GreenGuard-certified lacquer, and are available in the colors you can find in their shop or in any shade of your choosing! Paint matching is available for an extra fee.
(Images: Cheme Designs)
Around the Web
- Cheme Designs Releases New Eco Kids Furniture Line [Inhabitots]


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See All Contributors »
AMES, Iowa Iowa State fans should be reminded that their 2009-10 women's basketball regular-season parking permit is not valid at the first and second rounds of the NCAA Women's Basketball Tournament at Hilton Coliseum on March 21 or March 23. Since this is a NCAA sanctioned event, parking is available on a first-come, first-serve basis.
Forum Rules
All content owned by CycloneFanatic.com - All rights reserved 2005-09. By viewing this website you agree to the Terms of Service, Site Rules and Legal Disclaimer. The words, views, images and opinions expressed or provided by users do not reflect the opinions or views of CycloneFanatic.com or Iowa State University. The names, words, symbols, and graphics representing Iowa State University are trademarks and copyrights of the University protected by the trademark and copyright laws of the United States of America and other countries and are used on this web site under license from the University. Original site design, premise & construction by Jeremy Lind.


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Oakworks® 8" Semi Round BolsterThe design of this bolster was inspired by the expressed need of therapists for a larger half-round bolster. Unlimited versatility makes this comfortable and supportive cushion a great addition to your collection of positioning tools. It is available a choice of earth friendly, PVC free TerraTouch or UltraTouch upholstery. Measures 6.5"H x 8"W x 26"L. Made of Aero-Cel foam:
Completely takes the pressure off my lower back. I use it myself when I'm listening to meditation CDs. Lightweight, very comfortable. I love the orchid color. Would definitely recommend.
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Who doesn't love an intense game of Scrabble? It's great for the mind and a perfect chance to show off just how phenomenal your vocabulary is to everyone. From fancy words to dirty words, Scrabble is the queen of games, in this blogger's humble opinion.
While I know everyone will be celebrating with hours and hours of Scrabble tournaments today, why should you stop at just playing the game? If you really love Scrabble, don't you want to make it part of your life every waking moment of every day? Of course you do! True love means incorporating that love into every aspect of your life! At least this is what I gather from rom-coms.
If Scrabble is your passion, then here are some ways to either wear it or decorate your house with it. Your friends are going to be so excited to play against you when you're donning your special Scrabble dress.


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Goal for 2013: No Goals
Recent research suggests goals can do more harm than good.
Maybe it's time for a new year's resolution that trashes previous ones.
Maybe we should toss goals in the garbage.
Author Peter Bregman has a provocative essay at Harvard Business Review arguing that goals can do more harm than good. "It's not that goals, by their nature, are bad," Bregman writes. "It's just that they come with a number of side effects that suggest you may be better off without them."
Bregman argues that goals can generate unnecessary stress, and he cites a HarvardBusinessSchoolworking paper with the excellent title, Goals Gone Wild. It finds goals can lead to myopia, harm interpersonal relationships and motivate unethical behavior. The paper also saw these side effects of goals: "corrosion of organizational culture" and "reduced intrinsic motivation."
On the culture corrosion and unethical behavior fronts, the paper cites an example of Sears setting a productivity goal for its auto repair staff. Employees were asked to hit the target of $147 in sales for every hour of work. But the target prompted the staff to overcharge and complete unnecessary repairs on a companywide basis.
I think Bregman and the paper's authors are onto something. Another piece of the puzzle concerns the way performance targets may crimp creativity.
Innovation is a top priority for executives worldwide these days. So we recently asked readers about the most effective tools for spurring innovation among employees (our package on innovation and workforce management will be published next month). We found that "Giving employees freedom to spend time developing ideas and projects" ranked as the second-most effective approach (behind "facilitating more collaboration among employees"). But providing employees with freedom ranked a distant fourth when companies were asked what strategies they are actually using.
In other words, companies know employee autonomy to explore ideas is a smart innovation strategy. But they aren't tapping this tactic like they should. I suspect a major reason for the disconnect is that companies and employees are too focused on hitting their performance goals.
Yes, goals can be useful and sometimes can't be avoided. But today's business climate puts "measurable results" on a pedestal.
I'm among the guilty. I look for goals and goal-achievement in the companies I write about, in my own organization, in my own life. But lately, I've been feeling a lot of stress related to a book I'm co-writing and the deadlines I've helped to set. Fear that I won't hit the goals sometimes leads me to procrastinate. Which of course deepens the stress!
So I took Bregman's advice to consider an alternative to goals. Bregman (a former college classmate pal of mine) suggests thinking in terms of "areas of focus." That is, prioritize important matters but avoid specific targets. More journey, less destination.
And it seems to be working! I decided not to worry about hitting a goal I'd set to complete a chapter draft by the end of the week, and immediately a great weight lifted off my shoulders. But that didn't lead me to shirk the work. On the contrary, I dug into the project with as much gusto and effectiveness as I've had on it.
We'll see whether I continue to be a goal-less wonder-worker. But for now, I'm taking aim at targets.
My goal for 2013 is to put goals in the trash.
Ed Frauenheim is senior editor at Workforce. Comment below or email firstname.lastname@example.com.


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The descriptions of our streams and tracks are not yet posted on the website, but you can read about them here, then submit your proposal to any of the following tracks at
Then register for the LIVE #ibmpulse 2012 Webcast 9/28 where you can get all the details on speaking at Pulse, including whether or not you are eligible for a free pass!
Stream 1: Cloud and Smarter, Flexible Infrastructures
Businesses rely on their data center technologies to enable rapid innovation and the agility needed to respond quickly in today's highly competitive environment. Change management, provisioning, monitoring, scheduling and other key IT processes require a robust platform that can deliver services in a variety of ways, including virtualization, cloud computing and other delivery options. This stream will bring together clients, end users, systems integrators, IBM Business Partners and service management experts from across IBM to share best practices, roadmaps, real-world experiences, implementation examples and more.
Track 1: Service Delivery and Process Automation The ability to quickly transform a business requirement into a business service is fundamental to the success of today's organizations. This track focuses on how IBM Tivoli can help create an effective approach to managing service requests, incidents, change and configuration, and provisioning with an integrated set of IT service management solutions. Submit to this track
Stream 1: Cloud and Smarter, Flexible Infrastructures
Businesses rely on their data center technologies to enable rapid innovation and the agility needed to respond quickly in today's highly competitive environment. Change management, provisioning, monitoring, scheduling and other key IT processes require a robust platform that can deliver services in a variety of ways, including virtualization, cloud computing and other delivery options. This stream will bring together clients, end users, systems integrators, IBM Business Partners and service management experts from across IBM to share best practices, roadmaps, real-world experiences, implementation examples and more.
Track 1: Service Delivery and Process Automation The ability to quickly transform a business requirement into a business service is fundamental to the success of today's organizations. This track focuses on how IBM Tivoli can help create an effective approach to managing service requests, incidents, change and configuration, and provisioning with an integrated set of IT service management solutions. Submit to this track
Track 2: Service Availability and Performance Management If you're in operations, you understand the pressure to ensure high service availability and performance. This track will illustrate how IBM solutions provide the visibility and control required to manage critical business services in dynamic conditions in ways that are cost-effective and seamless to clients. Presentations will emphasize best practices and implementations – highlighting the use of common integrations, such as navigation, workflows, visualization and reporting. Submit to this track
Track 3: Storage Management IBM offers an extraordinary range of systems, storage, software and services based on decades of innovation -- all designed to maximize and protect information, a critical business asset. This track will explore how storage management solutions can address this challenge through a wide range of presentations that include best practices, implementation stories and case studies. Submit to this track
Track 4: Collaborative Development and Operations This track covers collaborative development and operations across the lifecycle in the context of service management, focusing on the principles of ITIL and other IT process methodologies. Key topics will include organizational collaboration, application performance, automated deployment and cloud computing. Ideal for architects, developers, process, and operations managers this track will highlight success stories and panels from clients and industry experts on how organizations can accelerate the delivery of high quality applications and services. Submit to this track
Track 5: Cloud and New Models for Service Delivery
Cloud computing and new delivery models are transforming the client experience and the economics of service delivery. This track will explore how private and public clouds can be securely harnessed – whether you choose to build your own, leverage prepackaged solutions, or have cloud delivered as a service. Sessions will explore how clients can successfully secure, visualize, and ensure the performance of virtualized and hybrid environments.
Stream 2: Smarter Physical Infrastructures
This stream will highlight key topics such as Enterprise Asset Management, Integrated Workplace Management Smarter Buildings, and industry-specific challenges that span integrated physical and digital infrastructures. Topics will focus on managing asset lifespan, energy efficiency, space planning and real estate portfolio management.
Track 1: EAM Best Practices In this track we will discuss and highlight techniques, processes, activities, and or incentives deemed extremely effective in delivering world-class best practices at your organization. Sessions will highlight quantitative and qualitative ROI and Return on Asset (ROA) data such as equipment uptime, inventory carrying costs, labor utilization, regulatory compliance, and maintenance operations. Submit to this track
Track 2: EAM Implementation and Upgrades This track will feature customers sharing their implementation or upgrade stories from legacy versions to the latest release including planning, tools and tasks involved, post implementation/upgrade review, and the improvements they have leveraged in architecture, functionality, security, and scalability. Submit to this track
Track 3: EAM Extended Usage Sessions in this track are designed to showcase the value of Maximo and TRIRIGA through their functional add-ons. Areas of interest for Maximo may include mobile, scheduling, linear, spatial, asset configuration manager, service provider, service request manager, and HS&E. Areas of interest for TRIRIGA may include request central, workplace reservation manager, strategic facility planning, viewer, application builder, and mobile to name a few. Submit to this track
Track 4: EAM Technical Sessions These technical sessions are designed to be co-presented by an IBM subject matter expert and a client or group of users in a panel setting. Areas of interest may include: workflow, reporting, migration, monitoring, archiving, and integration. Clients submitting an abstract will be mapped with the appropriate subject matter expert. Submit to this track
Track 5: Maximo Utility Working Group (MUWG) IBM is pleased to announce that the Maximo Utility Working Group (MUWG) agenda will focus on electric, gas, water and wastewater presentations and incorporate the new Maximo Supply Chain Users Group presentations. Waves of change brought by deregulation, globalization and new regulatory requirements have brought new challenges. Share your story on how you are leveraging Maximo to address these issues and other key challenges at your plant. Submit to this track
Track 6: EAM Industry Case Studies In this track we would like to hear from a multitude of industries: Energy, Manufacturing, Transportation, Chemicals & Petroleum, Mining, Life Sciences, Telecom, Facilities, Finance, and Public Sector – including State, Local, and Federal Government users, to highlight how you have addressed your industry- specific challenges with TRIRIGA and IBM Maximo Asset Management, more specifically by using one of Maximo's industry solutions. Submit to this track
Track 7: Smarter Buildings This track features IBM solutions for Smarter Buildings that allow building owners and managers to analyze and optimize real estate and facilities operations. IBM solutions for Smarter Buildings help customers create energy, operationally and space efficient buildings and helps them do so in a sustainable manner. Submit to this track
Track 8: Smarter Cities This track features IBM Smarter Cities solutions that allow customers to synchronize and analyze efforts among sectors and agencies as they happen, giving decision makers consolidated information that helps them anticipate—rather than just react to—problems so they can manage growth and development in a sustainable way. Submit to this track
Track 9: Integrated Workplace Management This track features solutions from TRIRIGA, an IBM company, that provide customers with advanced intelligence to help them make strategic decisions regarding space usage, evaluate alternative real estate initiatives, generate higher returns from capital projects, and assess environmental impact investments. Submit to this track
Stream 3: Security and Compliance
The boundaries of today's business infrastructures are being extended and sometimes obliterated by the emergence of cloud, mobility, social business, big data and more. Where does your business ecosystem start and end? Whom do you trust and whom do you not? We'll address these key security and compliance challenges in this track, demonstrating how IBM's security intelligence solutions can become the enabler of a business without limits.
Track 1: Securing Emerging Technologies Embracing new technologies, such as virtualization, cloud, and mobile computing, is an important aspect of how organizations stay competitive. However, the same technologies that can accelerate efficiencies can also pose new security challenges. This track will highlight how IBM can help you stay ahead of the evolving threat landscape and at the same time leverage the innovations made possible by emerging technology. Submit to this track
Track 2: Securing the Infrastructure and Mitigating Threats A secure infrastructure is not a static infrastructure. Every day, organizations have to face new security challenges, and the most successful organizations will be the ones that can not only react to these new challenges, but also anticipate them. In this track, we'll review some of the latest threat research and provide insights on how you can mitigate those threats, and optimize your infrastructure at the same time. Submit to this track
Track 3: Managing Compliance and Audit for a Secure Organization Regulatory and industry requirements—which are often disconnected or even contradictory—are increasing, making it difficult for enterprises to keep up without draining valuable resources. This track will focus on what it means to effectively manage compliance and audit in a world where the only constant, is constant change. Sessions will feature best practices and user experiences with designing, enforcing and monitoring security policies for users and their activities, information, systems and processes. Submit to this track
Stream 4: Leveraging Mobility
This track will explore how mobility is playing an increasing role across the enterprise. From standard voice and data services to business critical applications, mobility technologies are becoming critical to business operations. This stream will explore challenges around delivering and managing wireless mobility technologies, highlighting how visibility, control and automation play a vital role in the deployment and adoption of new services.
Track 1: Service Assurance for Communications Service Providers This stream will explore how effective network and service assurance enables control of the entire communication and content management infrastructure. It will discuss strategies and methods for gaining greater visibility into how key network and application elements impact service quality and delivery. Sessions will highlight best practices and client experiences across service quality management, event and performance management and other OSS/BSS functions. Submit to this track
Track 2: Cloud Service Providers Communications service providers (CSPs) around the world are looking for smarter ways of doing business. This track will explore the challenges around the deployment of a cloud services environment. It will feature customers who have expanded their portfolio of offerings to cloud and highlight how CSPs can quickly and cost-effectively create, manage and monetize public and private cloud services. Submit to this track
Track 3: Mobility and Endpoint Management This stream will explore how mobility is playing an increasing role across the enterprise – spanning the broad array of mobile devices, endpoints and networks that support enterprise mobility. From hot topics such as endpoint management and security and mobility technologies from Lotus, this track will cover how progressive companies are leveraging technology to enable companies to conduct business in entirely new ways. Submit to this track
Submit your proposal a line with any of the above tracks at http://bit.ly/oaAv2b


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Dolfin Reversible String Back Swimsuit Womens
$49.99 - $56.00
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Product Details
This Dolfin® women's reversible string-back one-piece swimsuit gives you double the options to create the perfect look. The brilliant print reverses to a solid color, making it a cinch to change up your style with each swim. The Xtra Life Lycra® spandex fabric promises a distraction-free, comfortable fit.
- 80% nylon, 20% Xtra Life Lycra® spandex
- Allover print reverses to solid color
- String straps with large back cutout
- Made in China


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Total Quality Logistics opens up 10th satellite office
September 26, 2011
Freight broker Total Quality Logistics (TQL) recently announced it has opened a new satellite office in Dayton, Ohio.
Company officials said the company is expected to hit $1 billion in 2011 sales and explained that this new office will play a significant role in TWL's continued growth and success. TQL added that this marks its tenth satellite office. The company arranges freight moves for thousands of North America-based customers and has a network comprised of more than 58,000 carriers.
"Dayton's talented work force, along with the local colleges and universities provided TQL with the opportunity for expansion in the area," said TQL Executive Vice President Kerry Byrne in an interview. "We see great potential in the city of Dayton for our organization and look forward to replicating the job growth we have experienced in Cincinnati and other markets."
When asked how long TQL had been planning this move to Dayton, Byrne said TQL has been aggressively expanding its operations outside of Cincinnati since the beginning of 2009, noting the company has opened 10 offices across the US with plans to add more in 2012.
In working with more than 7,000 customers and nearly 60,000 carriers, Byrne said that the closer TQL can get to its customers, the more it can learn about their needs and provide them with more value.
"The same holds true for the carriers with whom we work," he said. "Shippers all across the U.S. see value in the service that our logistics account executives provide, whether they are in Denver, Tampa or Dayton."
About the Author
Group News Editor
Subscribe to Logistics Management magazine
entire logistics operation. Start your FREE subscription today!


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PICKERINGTON, Ohio -- Some of the
most-talented American Motorcyclist Association members in the country aspire
to the Red Bull AMA Amateur National Motocross Championship presented by Amsoil
in Hurricane Mills, Tenn. But before they can line up at the National on July
28 through Aug. 4, these riders must first compete at one of 12 highly
competitive AMA Regional Championships, featuring the best motocross racers
from each region.
"It's such an accomplishment to qualify through the AMA Area Qualifiers
and earn a spot at the starting gate at the AMA Regional Championships,"
said AMA Motocross Manager Kip Bigelow. "The AMA Regional Championships
draw the country's best amateur motocross racers, competing for the opportunity
to race in the world's premier amateur motocross event."
The AMA amateur national program includes 50 Area Qualifiers and 12 Regional
Championships. Several thousand riders compete for the roughly 1,500 qualifying
spots up for grabs. These riders then advance to the Red Bull AMA Amateur
National Motocross Championship presented by Amsoil to race for AMA national
No. 1 plates in 36 classes. The best riders will compete for the coveted AMA
Motocross Horizon Award, presented to the amateur racer poised for success in
the pro ranks.
"The AMA Regional Championships are among the largest amateur motocross
races in the country, with as many as 900 competitors at any one race,"
said MX Sports Director Tim Cotter.
MX Sports is the AMA's promoting partner for the Red Bull AMA Amateur National
Motocross Championship presented by Amsoil. The partnership dates to 1982, when
MX Sports began managing the series and moved the championship finale to its
current location in Hurricane Mills, Tenn.
"The AMA is dedicated to providing the best tracks, the best facilities
and the best organizers to the AMA Regional Championship schedule for our
members, and 2013 is no exception," Bigelow added. "We look forward
to working with the MX Sports staff and the Regional Championship organizers to
provide an unforgettable experience and the opportunity to race in August at
the greatest amateur motocross race in existence."
The AMA Regional Championships kick off this coming weekend with the Southwest
and Mideast AMA Regional Championships, May 25-26. All regional titles will be
decided as June comes to a close.
The Red Bull AMA Amateur National Motocross Championship presented by Amsoil is
one of the most diverse national championships in America. It includes classes
for riders from 4 years old to 50-plus on motorcycles ranging from 50cc
minibikes to state-of-the-art highly modified 450cc motocross machines.
The success of the national championship has produced a long list of AMA
Supercross and motocross superstars. Riders who have progressed through the
program include Ricky Carmichael, Jeremy McGrath, Travis Pastrana, James
Stewart, Kevin Windham, Ryan Dungey, Ryan Villopoto and many more. Nearly every
professional racer competing in the Lucas Oil AMA Pro Motocross Championship
earned his way to the pro ranks through the AMA amateur program.
The AMA launched the amateur national motocross championship program in 1975.
That year, a series of regional races qualified 135 riders in three classes --
125cc, 250cc and open -- for the championship round in Baldwin, Kan. The
program evolved rapidly over the next few years to include skill and youth
divisions, with championship finales run in varying locations across the
country. In 1982, the event moved to its current location at the Loretta Lynn
Ranch in Hurricane Mills, Tenn., where it continues to crown the country's top
amateur motocross racers every summer.
For more information on the Red Bull AMA Amateur National Motocross
Championship at the Loretta Lynn Ranch, see www.mxsports.com. For more
information on AMA-sanctioned motocross competition, see www.americanmotorcyclist.com/racing.
AMA Regional Amateur
Motocross Championships
Northeast Regional
June 1-2: Unadilla (Youth), New Berlin, N.Y. (607) 965-8450
June 29-30: Budds Creek (Amateur), Mechanicsville, Md. (304) 284-0084
Southeast Regional
June 8-9: Muddy Creek Raceway (Amateur), Blountville, Tenn. (423) 323-5497
June 22-23: Gatorback (Youth), Gainesville, Fla. (407) 453-2056
Mideast Regional
May 25-26: Sunday Creek MX (Youth), Millfield, Ohio (304) 284-0084
June 22-23: Baja Acres (Amateur), Millington, Mich. (989) 871-3356
North Central Regional
June 15-16: Spring Creek MX (Amateur), Millville, Minn. (507) 753-2779
June 29-30: Byron Motosports Park (Youth), Byron, Ill. (815) 234-2271
South Central Regional
June 1-2: Freestone (Amateur), Wortham, Texas (713) 962-3386
June 15-16: Golden Pine (Youth), Prentiss, Miss. (601) 506-8669
Northwest Regional
June 8-9: Washougal (Youth & Amateur), Washougal, Wash. (360) 601-5347
Southwest Regional
June 25-26: The Ranch (Youth & Amateur), Anza, Calif. (949) 276-5153
Red Bull AMA Amateur
National Motocross Championship presented by Amsoil
July 28-Aug. 3: Loretta Lynn Ranch, Hurricane Mills, Tenn. (304) 284-0101


text: A retirement lifestyle increasingly can include part-time work to supplement pensions, Social Security, 401(k)'s, and other resources, or just to stay mentally engaged. Here's our list (arranged alphabetically) of the 25 best U.S. cities--actually, metropolitan areas or divisions--for a working retirement. We examined job growth trends and unemployment rates along with cost of living issues, taxes and other factors like crime rates, doctors per capita, and air quality.


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See All Contributors »
NCAA March Madness
NFL Playoffs/Super Bowl
College Bowl Season
NBA Playoffs/Championship
NHL Playoffs/Stanley Cup
MLB Playoffs/World Series
What are your favorite Playoffs or Championship?
Super Bowl
Can't beat March Madness!
Originally Posted by Cycofan1
Super Bowl
I must agree.
~Go Cyclones!
~Only you can make it happen.
~Never give up!
The first four days of the NCAA tournament are awesome.
NCAA tournament and it's not even close
Originally Posted by CycloneWarrior
NCAA tournament and it's not even close
I couldnt agree more and I am more of a CFB fan than CBB
Every vote for sudden-death playoffs right now.
I like the World Series, too, but the Cubs are never there, so I start to tune out.
Mostly the excitement of sudden-death, and the fact that anybody can win make March Madness my favorite, with the NFL playoffs in second place.
Kansas Must Be Destroyed
Sic Semper Jayhawks
Originally Posted by gocubs2118
The first four days of the NCAA tournament are awesome.
You've got brackets, beer, betting.... what am I missing?
Originally Posted by zumbro clones
You've got brackets, beer, betting.... what am I missing?
I'm OK with just brackets myself.
Maybe a good fattening snack.
March Madness and it's not even close. NCAA football would be a close second if there was a playoff. As it is, NCAA wrestling championships are second, NCAA football third, the NFL playoffs and SB fourth, everything else is an afterthought.
I think it's unfair to compare professional sports with NCAA sports.
Originally Posted by acrozier22
I think it's unfair to compare professional sports with NCAA sports.
What's unfair about it? It's just a poll asking you what is your favorite.
March Madness, and it isn't even close. If college football had a championship tournament, that would be number one.
Love the NCAA's. But if ISU isn't in it, I only really get into the first round or two - looking for the upsets. Unless there's a Cinderella still it, it looses it's appeal after the first weekend.
Otherwise, I enjoy The Masters in the spring. Don't know why, it's just fun to watch.
Bowl season is fun too, particularly if there's a major bowl with a mid-major in it - See Boise St/Oklahoma a few years ago.
Major sports - only really care if my team is in it.
Last edited by DaddyMac; 03-16-2009 at 11:26 PM.
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Part-time Assistant Professor
Anna Daley is a graduate of the Parsons the New School for Design/Cooper Hewitt Smithsonian Design Museum's joint Master's program in the History of Decorative Arts and Design. She received a BA in European History and Art History from Vanderbilt University. Anna has taught this course for several years online and she also currently teaches the History of Industrial Design at Montclair State University.
In addition to teaching, Anna is also a Sales Associate at Walker Zanger, one of America's oldest and most respected stone and tile firms.
New York City residents and visitors can also find Anna leading public tours as a docent at the Copper Hewitt at 11 am and 1 pm every 1st and 3rd Saturday of the month.
(Links to an external site.); one of America's oldest and most respected stone and tile firms.


text: Germany's diverse delights of music, culture, history and contemporary 'cool,' are tailor-made for customized guided tours. With your private guide in Berlin, discover former Soviet-style towers and the art-embellished Berlin Wall. Then, fast forward to cutting-edge and traditional museums, world monuments and renowned art galleries. At the famous Ch ...ristmas markets in Dresden, Munich, Cologne or Nuremburg, immerse yourself in the cheery atmosphere of brass bands and Alpine choirs, wooden toys and hand-blown glass baubles amidst twinkling lights. Or choose our Christmas Time River Cruise, stopping at numerous cities to visit fairy tale castles on the Rhine and shop at trendy fashion boutiques. Savor all manner of scrumptious delicacies such as gingerbread (sticky and sweet), icing-sugared stollen cake and spicy sausages. Or revel in every musical note written by Bach as you listen with headphones to superlatively recorded music at Leipzig's Bach Museum. Whatever your desire, whether it's joining Octoberfest's festivities or touring Dresden's hip urban neighborhood of cafés and art studios, let our experts plan your unforgettable Germany tour—your way and your pace.Show More


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Fairfax, VA (Sports Network) - R.J. Hunter scored 25 points to lead the
Georgia State Panthers to a 78-60 victory over the George Mason Patriots in a
Colonial Athletic Association tilt at the Patriot Center.
For the Panthers (14-14, 9-6 CAA), Devonta White added 23 points and Manny
Atkins posted a double-double with 14 points and 10 rebounds.
Sherrod Wright led the Patriots (15-11, 8-6) with 19 points and Marco
Gujanicic chipped in with 10 points.
Both teams shot greater than 50 percent from the field in the first half. GSU
was the hotter of the two teams, connecting on 62.1 percent from the field,
including 7-of-11 from beyond the 3-point arc, as it took a 51-36 lead at
The Panthers pushed their lead to as many as 27 in the second half, as they
cruised to victory and snapped a five-game losing streak to the Patriots.
GSU had a 21-9 advantage on second chance points and a 34-27 edge on the
The Sports Network


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Monday lineup: Royals host Cubs
Kansas City plated 9 runs in the seventh on Sunday as they defeated Seattle, 17-12. Today, Lou Piniella, one of the original 1969 Royals, brings his Chicago Cubs to Surprise Stadium for a 3:05 Central/1:05 local start. The game can be heard on 610 Sports in Kansas City and on Gameday Audio.
Here's the Royals lineup for today:
Coco Crisp – CF
David DeJesus – LF
Mark Teahen – 2B
Jose Guillen – RF
Mike Jacobs – 1B
Billy Butler – DH
Alex Gordon – 3B
Miguel Olivo – C
Mike Aviles – SS
Kyle Davies – RHP
Other scheduled pitchers:
Doug Waechter – RHP
Kyle Farnsworth – RHP
Joakim Soria – RHP
Juan Cruz – RHP


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Splintering bloc
Politics | Romney hopes Jews, usually an overwhelmingly Democratic constituency, will enter voting booths in November with the Middle East in mind. The prime minister of Israel hopes so too
One of Mitt Romney's biggest stump speakers isn't part of his presidential campaign. He doesn't endorse Romney, and he isn't even American. He's the silver-haired prime minister of Israel, Benjamin Netanyahu. The prime minister's increasingly vocal warnings about Iranian nuclear ambitions and his subtle criticism of the Obama administration could be a boon to Romney in the final weeks before the election.
Netanyahu may help Romney reach a constituency he's carefully targeted: American Jews.
The relationship between Obama and Netanyahu, never smooth, was rockier than ever in September. The Romney campaign hasn't missed any opportunities to call attention to Romney's longstanding friendship with Netanyahu in its effort to win over Jewish voters, a historically liberal voting bloc. Five weeks before the election, Obama led Romney by 3-6 percentage points in poll averages in several key toss-up states, including Florida and Ohio, where Team Romney is angling to win the support of thousands of Jews. In Florida, perhaps the most important swing state, Jews make up 8 percent of likely voters. The question is whether enough are worried about those issues this year to abandon traditional loyalty to the Democratic ticket.
"Look, Obama got 78 percent of the Jewish vote in 2008. I just don't think that's a realistic expectation for them again," says Tevi Troy, a Romney campaign advisor. "Obama has had a decidedly cold relationship with Israel that Jewish voters recognize and do not appreciate."
Romney is leveraging all the Jewish connections he can in order to reach those voters. Besides Troy, who served as a White House policy advisor and Jewish liaison under George W. Bush, Romney has tapped as a campaign advisor Dan Senor, a Republican commentator with connections to political leaders in Israel. Senor co-authored, along with former Jerusalem Post editor Saul Singer, the 2009 bestseller Start-Up Nation, about the success of entrepreneurship in Israel. It was Senor who arranged for Romney to visit Israel in 2007, 2011, and this July, when the candidate courted the estimated 150,000 U.S. citizens living in Israel who are eligible to vote by absentee ballot—and who tilt conservative. Among Israeli Jews, Romney is perceived as more concerned than Obama about Israel's interests by a ratio of 2-to-1, according to an August survey by The Israel Democracy Institute.
During the July trip Romney called Jerusalem "the capital of Israel"—a phrase the Obama administration has doggedly avoided using this year. (The Democratic Party removed symbolic language from its 2012 platform affirming Jerusalem as the capital of Israel, but reinserted it after public outcry and, reportedly, a directive from the president.)
Romney frequently highlights his friendship with Netanyahu, dating from 1976 when the two met while working for Boston Consulting Group. Years later, when Romney was governor of Massachusetts, Netanyahu visited him and shared anecdotes about reducing the size of government. Romney has boasted he and the prime minister "can almost speak in shorthand."
Netanyahu and Obama, however, grow increasingly unfriendly. The UN International Atomic Energy Agency reported that Iran added 1,076 centrifuges to its nuclear enrichment facilities over the summer, and Netanyahu suspects the nation is developing a nuclear weapon: He wants Obama to exert more pressure against Iran. On the anniversary of 9/11, after the U.S. State Department suggested the United States wouldn't set deadlines or "red lines"—thresholds for military action—as a way of pressuring Iran to halt its nuclear enrichment program, Netanyahu held a press conference in Jerusalem and asserted Israel's right to act independently: "Those in the international community who refuse to put deadlines in front of Iran do not have the moral right to put a red light before Israel."
That same day, Israeli officials said Obama had turned down a request by Netanyahu for a meeting, a claim the White House disputed. By evening Obama and the prime minister were talking on the phone, arguing for a full hour over what red line should be set before Iran. The two leaders couldn't agree on one.
In apparent frustration, Netanyahu appeared on U.S. morning talk shows the following Sunday to warn the American people that Iran was "moving very rapidly to completing the enrichment of the uranium that they need to produce a nuclear bomb." Political pundits said Netanyahu was meddling in the U.S. election, though the prime minister denied it.
Curiously, many American Jews don't list the Middle East among their top policy priorities. Most Jews, including the nonpracticing, are strongly liberal, while Orthodox Jews (about 1 out of 10 Jewish voters) tend to be conservative. Another growing segment of Jews (about 1 out of 5) eschews party loyalty and identifies itself as independent. That's the segment Romney needs.
A September poll conducted by the American Jewish Committee found 69 percent of Jewish voters in Florida supporting Obama. That's a drop of 7 percentage points from the support Obama received from the same group four years ago, representing a likely gain of between 30,000 and 40,000 votes for Romney in Florida—the state Al Gore lost to Bush in 2000 by 537 ballots.
Steven Windmueller, a political analyst at Hebrew Union College in Los Angeles, said Jewish support varies by election and candidate. Although John McCain only received 23 percent of the Jewish vote in 2008, Ronald Reagan picked up a relatively high 39 percent in 1980.
Jews have maintained an "embedded loyalty" to the Democratic Party since the presidency of Franklin Delano Roosevelt, Windmueller said. "He was seen as a figure that brought confidence and stability to the economy and to the country."
Nowadays, many Jews are rethinking their families' liberal commitments, labeling themselves independent or, more rarely, conservative. Windmueller said he's heard from many Jewish people who say it has become difficult to have dinner table conversations about politics because of polarized views: "It's gotten messy. Friendships have been broken."
Bruce Marks, a former Pennsylvania state senator and now an attorney in Philadelphia, is one of the more independently minded Jewish voters. Though Marks served as a Republican senator in 1994, he comes from a family of "liberal Democrats" and voted for Al Gore in 2000 and Barack Obama in 2008. His hopes four years ago that Obama might reinvigorate the economy evolved into disappointment with stimulus spending and the healthcare overhaul. "I'm also disappointed with his record in the Middle East and his absence of a really coherent policy to address Iran," Marks told me. "The bloom is clearly off the rose."
Along with other former Obama supporters who now back Romney, Marks appears in a video ad posted at MyBuyersRemorse.com, a website the Republican Jewish Coalition (RJC) created to prod other independent-leaning Jews into supporting the Republican ticket.
The RJC conducted its most extensive election effort ever this year, spending $6.5 million to identify and reach Jewish swing voters. In September the group recruited volunteers to target Jewish neighborhoods in Ohio, Pennsylvania, and Florida with phone calls and campaign literature that emphasized the problems in the Middle East.
Windmueller said Obama could lose this year 9 percent to 12 percent of Jews who voted for him in 2008. That prediction looked roughly on track as of September, when Gallup polling showed 70 percent of Jewish voters nationwide favoring Obama.
For Jews concerned about the Middle East, candidate Romney seeks to cast himself as the stronger ally of Israel. Obama has repeatedly stated he will prevent Iran from acquiring a nuclear bomb. Romney, during his July trip to Israel, announced a stricter policy: preventing Iran from gaining nuclear weapon "capability"—a policy he reiterated in a Sept. 20 conference call with around 3,000 Jewish leaders and rabbis.
The definition of "capability" is vague, though, and could refer to one of several thresholds Iran would have to cross on the path to building a nuclear bomb. It's a purposeful semantic distinction that gives Romney the flexibility to support a preemptive Israeli air strike against Iran to disrupt the country's enrichment program. It's also the kind of position Netanyahu failed to convince Obama to take in September.
Netanyahu claims to be neutral on the U.S. election, but it's probable a Romney win would increase his clout at the White House. Last year Obama angered Netanyahu by publicly calling on Israel to revert to its 1967 boundary lines in negotiating peace with the Palestinians. Romney, on the other hand, suggests he'd defer to Netanyahu on such matters: In a primary debate in Iowa last December, Romney criticized Newt Gingrich for making an inflammatory comment about Palestinians being "an invented people." Romney said, "Before I made a statement of that nature, I'd get on the phone to my friend Bibi Netanyahu and say, 'Would it help if I say this? What would you like me to do?'"
In voting this November, American Jews will decide between a president who keeps Israel's prime minister at arm's length, and one who views him as a Middle East advisor.
Iranian leaders will test the winning candidate: During his CNN appearance, Netanyahu claimed that, "In six months or so, [Iran] will be 90 percent of the way" toward enriching the uranium needed for a nuclear bomb. That's a prospect worrisome for more than just Jews.


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Sanford Canton-Inwood
The renovation and new construction on the campus of Sanford Canton-Inwood is designed to meet the growing and unique needs of the patients it serves. The design focuses on convenience for patients and their families, with a focus on privacy.
The project will renovate 17,630 square feet of current space, finish updates on 8,000 square feet of existing space and will add approximately 11,000 square feet of new construction and will be complete in July of 2014.
This is a $6.5 million project with $1.5 million being funded through a generous donation from the Canton-Inwood Area Health Foundation.
Patient benefits:
- Increased access to outpatient and same-day services
- Centralized scheduling and registration
- Convenient lab access
- Ease of movement around campus
- Larger physical therapy and rehab service areas


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|Holyoke Pharmacy to open this month
|Written by Brenda Johnson Brandt
Having received licensure for Holyoke Pharmacy on March 1, owners Jamie Hanes and Jason Burke announced they will be opening their local store later this month.
The owners were in Holyoke last week to begin to stock the store shelves, and said they will either be opening Monday, March 18, or the following Monday, March 25.
Remodeling on the southwest corner of Holyoke Marketplace at 112 E. Carnahan began in late October for the new pharmacy.
Both Hanes and Burke are natives of the area, having grown up in Imperial, Neb., graduating from Chase County High School.
Hanes earned his pharmacy degree nine years ago and has been back in Imperial for four years, working with his dad, Jim Hanes, who owns Adams Drug.
Burke will graduate from the University of Nebraska Medical Center pharmacy school in May and hopes to be licensed and ready to go by June.
Both are pleased to have the opportunity to live in rural America. Having gone to school and worked in the cities, they value life in smalltown America.
When Burke was completing a rotation at Adams Drug last August, he and Hanes started talking about the possibilities of pharmacy ownership.
As Holyoke was without a full-service pharmacy at that time, they approached Holyoke Marketplace owners Brad Moline and Kenny Owens about the possibility of renting space there.
Plans escalated and construction began.
Holyoke Pharmacy owners Jason Burke, pictured at left, and Jamie Hanes, Pharm.D., look forward to the opening of their store in the southwest corner of Holyoke Marketplace later this month. —Enterprise photo
The duo also made another area pharmacy purchase, taking possession of Grant Pharmacy in Grant, Neb., on Feb. 1.
While Adams Drug in Imperial will be Hanes' home store and Grant Pharmacy will be Burke's, they both plan to be heavily involved with Holyoke Pharmacy.
Down the road, they said it is their plan to bring another pharmacist to the Holyoke store, which will provide relief time for all of them.
They value their time off and want to make sure they have enough staff to provide quality service for their stores.
"We want to have time for individual attention to our customers to make sure we can meet their needs," said Burke. "We're not going to be rushing things. If customers need something, we're going to look for it and not spread ourselves so thin we can't provide for their needs."
In the hallway outside the pharmacy area, Holyoke Pharmacy will shelve over-the-counter drugs. They said they'll experiment with the set-up of those shelves to see what works best.
Burke emphasized if customers want items that aren't stocked here, they should tell them so they can see if they can get it from their other stores or they will special-order the desired products. "We want to make sure we stock products people want," he added.
The two Holyoke Pharmacy owners and their wives had the opportunity to attend the Melissa Memorial Hospital Foundation Legacy Event Feb. 23, and said they were pleased to see people's commitment to the health care system in Holyoke.
"With the pharmacy, we want to be a piece of that health care puzzle," said Burke. The duo said they look forward to offering top-notch pharmacy service to complement health care services that already exist in Holyoke.
Hanes graduated from the University of Nebraska-Lincoln in 2000 with a B.S. degree in biology and earned his Pharm.D. degree from Creighton University in Omaha, Neb., in 2004.
He served a one-year residency at the University of Iowa Hospital in Iowa City and was at the Mayo Clinic in Rochester, Minn. for almost four years before returning to Imperial to work with his dad at Adams Drug.
Hanes' wife Brandy is a nurse practitioner at Chase County Clinic in Imperial, and the couple has two children: Madelynn, 8, and Miles, 5.
Burke earned his bachelor's degree in business administration with a major in accounting from UN-L in 2009, then went on to pharmacy school at the University of Nebraska Medical Center in Omaha, Neb.
He started his 10th four-week rotation Monday, March 4 and will graduate in May. His series of rotations took him to both hospital and retail pharmacies.
Burke's wife Whitney is also a Chase County High School graduate and is a registered nurse. She recently accepted a job at the hospital in Ogallala, Neb., where she will begin this month.
Burke said he and his wife are excited to be returning to this area, as they didn't dream they would have the chance to come back closer than several hours away.
Holyoke Enterprise March 7, 2013


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The proliferation of Standards Setting Organizations (SSOs) began in the mid-1980s as a response to a perceived threat by the Japanese Fifth Generation Computer Systems project (FGCS) to the U.S. semiconductor industry. Several major U.S. chip and computer makers decided that a joint research initiative would help them meet the threat to U.S. chip making dominance. Unfortunately, U.S. law considered joint activities of this type to be in violation of anti-trust and anti-competitive laws. The remedy to this issue was to pass enabling legislation (National Cooperative Research Act of 1984, Pub L. No. 98-462) (NCRA) which allowed the creation of consortia for joint research and development. Soon afterward, the Microelectronics and Computer Consortium (MCC) was created to engage in joint research in multiple areas of computer and chip design.
It should be noted that – at this time – the formal standards organizations in the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC) had significant standardization activities occurring – especially in the area of the Open Systems Interconnect (OSI) arena. Recognizing that the environment was becoming more important to business, the leaders of the ISO and IEC IT standards bodies proposed a merger of the ISO and IEC committees – creating the first (and so far, only) Joint Technical Committee (ISO/IEC JTC1) to make standardization easier.
However, the formalists failed to provide adequate testing and verification of the very complex Open Systems Interconnect standards, and this need was quickly met by the Corporation for Open Systems (COS), (1986), a consortium of suppliers and users to ensure that OSI implementations were interoperable. Although short lived (in standards years), COS showed the way for the use of the NCRA to be used "differently." It showed that a private organization (a consortium) could accomplish quickly what the formal standards organizations couldn't – and do it with a highly focused approach that didn't need all the "international" approvals and compromise.
The late 1980s and early 1990s saw an explosion of similar organizations – all of which were created by companies to "expedite" time to market (as well as the creation of the market, it was hoped). The most successful of these was the Object Management Group (OMG) founded in 1989 to create a heterogeneous distributed object standard. The Manufacturing Automation Protocol/Technical Office Protocol (MAP/TOP), championed by GM and Boeing respectively, came to life during this time, as did the User Alliance for Open Systems. There were also consortia created to push a particular provider's technology (88open Consortium and SPARC International come to mind).
Of course, these groups began to strain the limits of the 1984 cooperative R&D legislation, so Congress modified the law in 1993 and passed the National Cooperative Production Amendments of 1993, Pub. L. No. 103-42, which amended the National Cooperative Research Act of 1984, Pub L. No. 98-462 and renamed it the National Cooperative Research and Production Act of 1993. (NCRPA)
And it is this Act that most consortia use to legitimize their existence. It provides limited immunity from anti-trust, provides some cover for anti-competitive behavior, and provides a basis for an organizational framework upon which to build your own consortium. However, this is not the end of the quest for "the nice thing about standards is that you have so many to choose from" syndrome. While the tools and mechanism for creating a consortium were now in place, the actual creation takes a little more effort.
The next post will look at how the "business of standards" has grown in the 20 years since the NCRPA was passed – and how consortium have changed standardization in the Information and Communications Technology (ICT) world.
Carl Cargill
Principal Scientist


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Susan G. Komen Northwest NC is working to better the lives of those facing breast cancer in our community. As part of the world's largest and most progressive grassroots network fighting breast cancer, through events like the Susan G. Komen Northwest NC Race for the Cure, we have invested more than $4.2 million in local breast health and breast cancer awareness projects in Alamance, Davidson, Davie, Forsyth, Guilford, Randolph, Rockingham, Stokes, Surry, Wilkes, Yadkin counties.
eBay for Charity
Registered with eBay for Charity.