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Monday night, there were nothing but superlatives coming out of TD Garden.
Sitting in coach Claude Julien's Game 3 press conference after the Bruins had just beaten Sabres 2-1 (click here for the complete recap) to go up 2-1 in their quarterfinal playoff match was like listening to a principle read of the virtues of all the students on the honor roll.
Granted, you have to do something good to make the honor roll. And on Monday evening, a lot of Boston players did something good. Patrice Bergeron scored the game-winner on a heads-up one-timer from the circle. Mark Recchi fed him after battling Buffalo forward Tim Kennedy in the corner. Tuukka Rask let in a soft goal to Michael Grier in the first — then shut the Sabres down for final 53 minutes. Johnny Boychuk made a big hit. Dennis Wideman scored a goal and assisted with Recchi on the game-winner.
"That's just Dennis [Wideman]. When he decides to put him mind to it and determined, that is what you get out of him," Julien said of the much-maligned defenseman who has turned it around late in the season. "Again, repeating myself, but no better time to do it than now. That goal was a hard shot that I didn't even see it go in from the bench."
The list goes on.
Let's try not to get too high on the Bruins. Yes, they won Game 3 in gritty fashion and they may be playing some of their best hockey of the year in terms of effort and execution. But Ryan Miller is perfectly able to turn the Bruins chances to dust. Boston has only one player from the Canadian national team, not the whole squad, after all.
Yet, a big playoff win for a team that many expected to be hitting the links at this time of year is something noteworthy.
"The biggest thing is to stick with it, and I think that is what we did," Julien said. "We stuck through it through thick and thin, and I guess I have been around long enough to know that you are going to go through some tough times.
"But if you grab some momentum at the right time of the year a lot of things can happen. We believed in ourselves and believed in our group and we stuck through and things started turning around and when things started to turn around we got more confident and played better."
Here are the three things we learned Monday night.
For the second time in the series, a scrum in front of the net turned into a bout of face-washes and fisticuffs. The Sabres' first offensive series after Bergeron scored the go-ahead goal had Andrew Ference and Buffalo captain Craig Rivet get into a pushing match that led to Rivet putting Ference on the ice, and escalated to the point that Vladimir Sobotka got into his first official NHL fight with Andrej Sekera. Ference, for some reason he could not figure out, ending up taking a misconduct penalty because of it … even though it was Rivet who sent him flying.
"No, but they were mad at me," Ference said about if he got an explanation from the officials as to his misconduct. "I thought I was drawing a penalty, not taking one."
Patrick Kaleta got a misconduct penalty in Game 1 after a similar series, even though it was Milan Lucic who took on both Toni Lydman and Steve Montador at once with fists a flailing.
Sobotka and Boychuk had been firecrackers in this series
"It was OK. I didn't want to fight, but he punched me first and I said, 'OK, let's go,'" Sobotka said. "It is just both teams they play hard. It is war, you know, on the ice and we just have to battle and play like we play the last two games."
The Bruins and Sabres have now played nine games this year, which is the maximum that any teams could play this time of year. Each roster has gotten to know the other's quirks and tendencies and what will work on the ice and what may make somebody mad or draw a penalty.
"I have some guys that I don't like, you know, but I don't want to tell who but we turn around and I think it is going to be a great next game," Sobotka said.
Bruins hockey in 2009-10 definitely hasn't been about highlight-reel material. Milan Lucic did not put anybody through a wall, Phil Kessel did not score any pretty goals (at least not for Boston) and Marc Savard was way short of his quota of nifty passes.
It is reminiscent of NFC Central football, where every team is built on defense and the running game. It may not look great, but it can be effective.
Neither team in this series is going to go crazy for any significant portion of time. Both teams are too well-coached to let the other one get to far off the leash. Each squad has significant missing players (Jochen Hecht and Thomas Vanek for the Sabres, Savard, Mark Stuart and Dennis Seidenberg for the Bruins) and the styles are similar enough that each game is going to look basically the same. Game 3 was a reverse clone of Game 1.
"Not a lot of changes," Miller said on the style of the series. "A couple of miscues on our part led to goals. That is the difference."
The first miscue was a mutual penalty really that led to open ice for the Bruins. Paul Gaustad and Ference took matching roughing penalties in the first period at 13:18 that led to two minutes of 4-on-4 hockey. Towards the tail end of the set, Sobotka rushed down the right wing with Matt Hunwick drawing the defense in deep, then centered the puck to the slot that Hunwick had just cleared out to the one-timing stick of Wideman who screamed it around forward Michael Grier passed Miller's stick.
"Even if I did see it, it was probably one you have to be standing up and anticipating it. You have to tip your hat and move forward," Miller said. "Then the last one, it was a big shot. I was trying to step out and get some kind of position and it just hits me and goes in."
The "last one" refers to Bergeron's game-winning bullet that was set up by Recchi winning a battle by putting Tim Kennedy on the ice in the corner and zipping the puck back to Bergeron — who would have hit it a country mile if it had not been stopped by the net.
"It was kind of a broken play, because they almost stopped me at the redline before I dumped it so we got lucky on that one," Bergeron said. "And [Recchi], like I said, won his battle and I think he surprised the other team by winning it so clean like that and it made me open."
Recchi has been the epitome of spinning wheels and patience for the Bruins. He always keeps his feet moving on the ice because he knows that if he is always there for the battle or in the right spot then patience will be rewarded. Hockey is a very cyclical, fluid game augmented by jarring hits and sudden goals, and watching the Bruins when they are playing well like they have been for the last few weeks is a matter of knowing that the play will come as long as the effort is behind it.
Boychuk has become the villain of this series, and the B's 26-year-old rookie seems to be enjoying it. He is an often-sarcastic individual who has developed a certain swagger and confidence especially as he has been picking up big minutes down the stretch for Julien. He hits hard on the ice and throws his body at the puck with significant fervor, perhaps the type of desperation only developed by a guy who at times thought he would end up as a career minor-leaguer.
Whether purposefully or not, Boychuk is responsible for taking out Thomas Vanek, and he just about took Matt Ellis' head off at around the 5:45 mark of the second period when the forward was trying to clear the puck after a particularly effective Bruins shift in the Sabres zone. Boychuk stepped up and took Ellis down, separating him from the puck — and his wits — as Ellis was visible wobbly when skating back to the bench.
"Our forwards were coming back, so I knew that even if I missed him, our forwards would have been there to cover me up, so it makes it a lot easier when our forwards are back-checking like they were tonight," Boychuk said.
The hit lit up TD Garden and provided the momentum that the Bruins would use to keep the game close into the third and win it on Bergeron's goal. Boychuk was happy enough to contribute to the energy in the building.
"Well, yeah, you know, any way possible," Boychuk said. "If you are not going to be [Bergeron] and score all of these goals, you have to do something else, I guess."
If Vanek comes back, he certainly will remember Boychuk. So will Ellis, if he remembers the train that hit him. Does that make Boychuk a Buffalo villain?
"I guess so," Boychuk said. "I'm no villain."
Dale, Michael and Jerry dig into the details of this draft for the Patriots with ESPN's Mike Reiss.
Giardi and Price discuss the Tom Brady appeal getting overturned and Roger Goodell's victory tour. The guys can't believe the victory lap and some of his behavior. The more you listen to him, the more frustrating his behavior becomes.
Giardi and Price break down how the teams in the AFC East altered their futures after the NFL Draft weekend.
Jeff Goodman calls Mike and Rob to drop a ton of knowledge on the upcoming NBA Draft and some of the names available. Sorry fans - he doesn't see Kevin Durant or any big-named free agents coming to Boston and thinks they'll end up making the third pick this season. He also says that there is NO WAY he would trade next year's Brooklyn pick because the draft will be very deep. He discusses the chances of trading with Philly for Okafor, why he like Kris Dunn so much and much more.
Brad Stevens makes his first appearance on the Dale and Holley with Thornton show. We discuss the Atlanta series and what went wrong, and where the Celtics go from here.
Ian Thomsen of NBA.com joined Sam Packard and Jared Weiss to discuss the next moves for Danny Ainge and the Boston Celtics with the NBA Draft Lottery rapidly approaching. They discussed the crazy ending to Game 2 of Thunder vs Spurs and picked the player they would build their pretend new franchise around.
Danny Picard recaps the Red Sox 5-3 win over the Blue Jays.
Who is to blame for the Red Sox 10-9 loss to the Blue Jays? Danny points the finger.
Tim talks with Red Sox manager John Farrell before the Red Sox game against the Blue Jays. John talks about Clay Buchholz move to the bullpen and adjustments he expects him to have to make going from the starter to the bullpen.
DJ and Pete continue to assess the season that was for the Bruins and look toward the future for the franchise and how they can improve.
DJ and Pete are together for the final Sunday Skate of the season. They get into their overall thoughts on the season, the Bruins keeping Claude Julien on as head coach and the end-of-season press conferences last week. They discuss the rebuild process, what the Bruins need and how they can obtain it. Plenty of callers have their own theories and opinions on all of these topics as well.
Butch is joined by two-thirds of the Sunday Skate show in DJ and Pete. The guys discuss the problems with Bruins including leadership and grit, who should stay and who should go and if Claude is to blame.
Lucy's parting shot after not taking the job is to attack Dino for how he treats producers.
Bernie Sanders wants to debate Trump.
Yaz was on hand at Fenway last night to honor the '86 team and Wade Boggs' number retirement.
Christian shares his fear of shark attacks...in a pool.
Travis Shaw talks about Clay Buccholz, David Ortiz, and his fear of the dark when he was a kid.
No one is safe from OMF's Whiner Line.
Laroy Streat keeps setting fire to the airways and talks people singing his Freestyle Fridays to him when they see him on the street! Catch our guy every friday via final drive! He's must listen radio!
We end the week with the best in sound Laroy Streat continues to set fire to the airways with his music.
The guys talk Red Sox pitching and the problems that could arise with Buchholz struggles.
Danny Picard recaps the Red Sox 5-3 win over the Blue Jays.
Mut recaps the Sox 8-2 loss to the Rockies.
Mut recaps the Sox 10-3 win over the Rockies.
Jerry is joined by Graig Murphy to talk stand up comedy. Until Graig pretty much hijacks the podcast to tell his side of the "Big Show Unfiltered" story.
Ben and Russ preview the Champions League Final between Atletico Madrid and Real Madrid. Who we want to win, who we think will win, and why. We also talk about our wishes for the USMNT.
The Dennis and Callahan malcontent is joined by former WEEI personality Pete Sheppard to talk about his past involvement with the station and his current gig in New Hampshire. You'll be glad to hear Pete hasn't changed one bit.
Lucy's parting shot after not taking the job is to attack Dino for how he treats producers.More from this show
The Dennis and Callahan malcontent is joined by former WEEI personality Pete Sheppard to talk about his past involvement with the station and his current gig in New Hampshire. You'll be glad to hear Pete hasn't changed one bit.More from this show
No one is safe from OMF's Whiner Line.More from this show
Deflategate rage explodes on the guys. They argue whether Brady is dragging it out or he should defend his innocence and the callers get in on the action.More from this show
Mike and Rob discuss how OTAs are not the forum to make decisions on the future of the team and how fans on Twitter can't accept that. They also get into the contract situations for Malcolm Butler and Dont'a Hightower.More from this show


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Who is this guy? Tanev called up ahead of NHL vets Parent, Baumgartner
Chris Tanev takes a hit. All signs point to the Canucks dressing Chris Tanev Tuesday night in Colorado, the continuation of a remarkable Cinderella story. The Canucks called up the 21-year-old ahead of Ryan Parent and Nolan Baumgartner – and … Continue reading
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In a scoreless tie, the Wild scored on a second period power play even though the puck disappeared several times, including once directly under Cory Schneider's glove. But the play was never blown dead, allowing Andrew Brunette to score on … Continue reading
Canucks Midterm Fantasy Report Card
This article appeared in print in The Province's White Towel section The Canucks have been roasting the rest of the league recently and their balanced scoring approach, coupled with red-hot goaltending, has earned some of them top marks on their … Continue reading
Andrew Alberts knocked out of game with shoulder injury. Here comes Chris Tanev.
First, Sami Salo is nowhere near coming back. He's still skating gingerly, and showing no speed and is not taking hard turns during practices. There are times when he buckles a bit when skating. All this has made it clear … Continue reading
Canucks recall Chris Tanev
With Aaron Rome expected to miss three weeks, the Canucks have called up defensive prospect Chris Tanev. Tanev is with the team already and will be Vancouver's seventh defenceman, an insurance policy if any of their top six is injured. … Continue reading
Sarowa leads No. 3 Mouat past No. 1 Brookswood in Top 10 girls Shoot-Out final
W.J. MOUAT 68 BROOKSWOOD 54 Mouat's Ashleyn Sarowa was a masterful floor general in Saturday's Top 10 final. (Jenelle Schneider, PNG) COQUITLAM — It's a crowded house on the top floor of the B.C. senior girls basketball world, but Abbotsford's … Continue reading
Injuries, fouls force Clan to finish with four in GNAC loss to Alaska-Fairbanks
BURNABY — And then there were four. The Simon Fraser Clan men's basketball team, short-staffed with just eight players to begin action Saturday, finished up a disappointing evening with a rather improbable loss. Star point guard Justin Brown was injured … Continue reading
Rome out two-to-three weeks, Bolduc less clear
No swelling and no pain left Aaron Rome encouraged despite an MCL knee sprain which forced him out of Friday's game. "I likely won't know how bad it is for sure until I get back to Vancouver and get a … Continue reading
A few loose ends
A bit of perspective is needed when it comes to digesting football tidbits at this time of year. Paul McCallum does a radio interview Saturday to suggest he's being asked to step aside by the Lions, for example, and its … Continue reading
Luongo controversies: Botch counts 'em down
Hey Province Sports readers/Canucks fans … In Sunday's Province, pick up our 28-page White Towel pullout section, featuring this month's cover boy, Manny Malhotra. One of the features in the White Towel? This beauty from Jason Botchford: 10 interesting … Continue reading

subset: commoncrawl


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Manukau East MP Ross Robertson is set to become the new Assistant Speaker of Parliament.
The move is part of Labour leader Phil Goff's reshuffle in the wake of the resignation of MP Darren Hughes.
Mr Robertson, who was Assistant Speaker for two terms under Labour, will take over from fellow Labour MP Rick Barker who will replace Mr Hughes as the party's chief whip.
While sorry to be giving up his senior citizens' portfolio, Mr Robertson says he'll enjoy "the cut and thrust of applying speakers' rulings and standing orders".
Parliament can appoint up to two MPs as Assistant Speakers.
- Manukau Courier
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Sport: Karaka claim Challenge Cup and Don Shuker Cup double
What's On: Students get chance to perform at Matariki Rhythmz
Out & About: Counties Manukau breastfeeding peer support graduation
Anglican Trust for Women and Children head urges action over child abuse
Papatoetoe High School students get stuck into Youth Week
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Delays on Auckland roads after crashes
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'It was bloody scary' – plane door appears to come ajar mid-air during domestic NZ flight
Family First applauds west Auckland school's ball dress code
Kelston Girls College mourns death of high achiever Penina Latu
Stormy weather hits Auckland, two houses struck by lightning
Allergies keep Auckland woman living in isolation
Police discover body inside van in south Auckland
Auckland police look for Head Hunters gang member after parole breach
Are our classrooms becoming overcrowded?


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Schaum's Outline of College Chemistry, Ninth EditionConfusing Textbooks? Missed Lectures? Not Enough Time? Fortunately for you, there's Schaum's Outlines. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get
Schaum's Outline of College ChemistryTough Test Questions? Missed Lectures? Not Enough Time? Fortunately, there's Schaum's. More than 40 million students have trusted Schaum's to help them succeed in the classroom and on exams. Schaum's is the key to faster learning and higher grades in every subject. Each Outline presents all the essential course information in an easy-to-follow, topic-by-topic format. You also get hundreds of
Organic Chemistry Demystified 2/EYou don't need genius DNA to master organic chemistry! Whether you're taking a chemistry class or studying for the MCAT or DAT, Organic Chemistry Demystified is your formulas for learning or reviewing fundamental concepts and theories step-by-step. This practical guide eases you into this sometimes challenging subject, starting with atomic structure and mass. As you progress, you will master
$89.99This concise textbook meets several objectives. First, the topics included were selected in order to provide essential information in the major areas of inorganic chemistry (molecular structure, acid-base chemistry, coordination chemistry, ligand field theory, solid state chemistry, etc.). These topics form the basis for competency in inorganic chemistry at a level commensurate with the one
Chemistry Study Guide: Atom Structure, Chemical Series, Bond, Molecular Geometry, Stereochemistry, Reactions, Acids And Bases, Electrochemistry. (Mobi Study Guides)Boost Your grades with Chemistry Study Guide. Navigate from table of contents or search for words or phrases.Audience:Intended for everyone interested in Chemistry, particularly undergraduate and graduate science students, medical students, nursing students, physician assistants students, and advanced high school students.FEATURES:- Atomic structure - Chemical interactions and bonding -
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Bring a buddy.4.54 / 5.00 10,554 Views
Yugi and Kaiba have a duel to the death!4.46 / 5.00 39,734 Views
Vampire Pixel in the Neon City
A sinister deal is underway in the underbelly of Neon City4.33 / 5.00 11,970 Views
dont always look at the at the foreground (look at the back ground occasionally)
just ok...
too damn short boy. It would have been a lot better if it was longer, but it was a very good movie.
That was great. I totally agree with mrincognito.It was short and sweet. See kids its good to smoke. The guy who died died healthy and all but if he smoked he probably would've lived unhealthy for another year or two. You never no when you may run into a disgruntled pyrokenesis weilding lucifer in a bar. So smoke 'em if you got 'em.
pretty good movie! I love it!
this was good! The animation is pretty good and the sound too but you should try to make longer and put at the loading screen how the loading is progressing anyways this is super keep it like this.


text:
It's a short walk from Time Out New York's midtown west office to The New York Times' headquarters. And the weekly magazine appears to have inched closer to the Grey Old Lady's new media monetization strategy, taking a page out of the year-old deals platform called TimesLimited.
It's part of Time Out's digital reboot since Oakley Capital bought a majority stake in the company 11 months ago. Since then, the publication, which is in 63 international markets, says it's made 60 digital hires while increasingly focusing on mobile apps.
The company seems most excited to join the daily deals fray, where Groupon leads while many publishers test the waters.
Dubbed "Offers and Experiences", Time Out has partnered with OpenTable (restaurants), Fandango (movies), and Audience View (theater) to offer its web and mobile readers specials around New York City. According to a magazine rep, the publication's London and Paris editions are also using the deals platform "with plans for further expansion in the future."
"It's the first time Time Out…has done anything similar to bookings" in the United States, the rep said via email.
Time Out has also relaunched its website and released an iPad app, while upgrading its iPhone app.
The iPad app uses personalization technology Time Out acquired when it purchased LikeCube in August. According to a statement by the magazine, the app will serve as a "citywide recommendations engine, featuring daily content tailored to individual interests." Its deals/e-commerce platform is featured on the app.
The iPhone app has been enhanced to better provide users with arts, entertainment, and venue information, Time Out says. It plans to release an Android version in the coming weeks.
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Ellen Fricas, 87, of Oak Brook, Aug. 9, 2008, beloved wife of the late Gery; loving mother of Irene (Tony) Tarosas, Milda (Vince) Daumbrauskas, Victor (Cynthia)
Fricas and the late Vera Buscaglia; proud grandmother of Tony (Michelle) Tarosas, Janet Baldridge, Nicholas, Ashley and
Alexander Buscaglia, Peter Daumbrauskas, Donna (Steve) Mazer, Sofia and Paul (Billie)
Daumbrauskas; survived by cherished nieces and great-grandchildren. Memorial service Tuesday, 5 p.m. at The Congregational Church of Algonquin, 109 Washington St., Algonquin, IL 60102. In lieu of flowers, memorials may be made to the Ellen Fricas College Fund c/o Glenview State Bank, 1707 Shermer Rd., Northbrook, IL 60062 for her grandchildren's college education. Arrangements by N. H. Scott &
Hanekamp 847-998-1020.
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text:
"'The Perks of Being a Wallflower,' by Stephen Chbosky. It's about a teenage boy learning about sex, drugs and teenage life."
"'The Grapes of Wrath,' by John Steinbeck. I read it for school, and to be quite honest, I found to be fairly boring. It still had some good qualities, though."
"'Backfire,' by Loren Baritz. It's an older history book on Vietnam. The author was an advocate against the war."
"'Ishmael,' by Daniel Quinn. It's about a gorilla and a man. The gorilla is his mentor and opens his eyes to how humanity is treating the Earth and the environment."
sunflower_sue 10 years, 1 month ago
What? we get 2 questions today? OK, I'll bite. To answer question #1: I'm reading "The Fort at River's Bend." It's book #5 of a series of books by Jack Whyte on the Chamulod chronicles.
ms_canada 10 years, 1 month ago
What am I reading? I am re reading the Camulod Series by Jack Whyte. I am on book #3 now, The Eagles Brood. Wonderful books, right Sue? This long series, 8 books in all, concerns the events in Britain following the withdrawal of the Roman Legionaries in the 5th century. They tell the story of a dream come true for ex Legionary soldier Caius Britannicus. He dreamed that he and his friend Publius Varrus could set up a colony, which they called Camulod, where people could live in a secure, orderly society. They built a fort and an army in the Roman style and hoped that it would protect them from the Pict, Scotii and Saxon raiders. Publius Varrus was the great grandfather of the famed King Arthur. Very good books.
H_Lecter 10 years, 1 month ago
It's a great cookbook, "Marinade Anything" subtitled; "Eat the organs or your wasting the best part"
sunflower_sue 10 years, 1 month ago
Ms_C, Yes, an excellent series...and who knew that I would find warfare and weaponry in the 7th-8th century fascinating???
My #1 recommended best all time read: "The Pillars of the Earth" by Ken Follet. Not your typical Follet genre but by far his best! Couldn't put that one down.
Diana Gabaldon's "Outlander" Series are also some quality reads.
H_Lecter, I have a collection of cookbooks, myself. My all-around favorite is "American Classics" by the editors of "Cooks Illustrated" magazine. Great book! I highly recommend the "High roast crisp- skin Chicken with potatoes!" So good! Definitely not a dish for the dieters! Lot's of butter, garlic, and the skin on the butterflied chicken is so crispy...just like the golden, thin sliced potatoes that have soaked up all that butter and chicken fat! Ooooooh Yum!!!!
And, H_L, I LOVE liver!
paladin 10 years, 1 month ago
"We Work and Play", from the Dick and Jane series.
H_Lecter 10 years, 1 month ago
S_S, I'll have to check out the recipe. I do seem to remember that you have a talent in the kitchen. The illustrated cookbooks are my favorites as well. Most of them however don't mention my favorite way to marinade liver (from the inside). The liver absorbs whatever is in the blood, so if the donor's blood stream can be flooded with wine, garlic, and onions...
bearded_gnome 10 years ago
YO DEAN! try rereading the Grapes of wrath...boring? what?
try some other Steinbeck, like the cannery row/sweet thursday, if ya' want more interesting. or, the Pearl, that's very moving. c'mon Dean, maybe you just need to turn off the TV and try rereading 'Grapes? when you read it, remember those are real people depicted in there. it might help if you saw the movie to assist you in your understanding.
finally, I'm still reading "the seven Pillars of Wisdom" by TE Lawrence, aka "lawrence of arabia, tells the story of how he assisted the arabs in rebelling against the tyrany of the Turks and thereby assisted in Britain/U.S./France winning WWI. very compelling scenics, personal descriptions, and lots of real life application of the principles of warfare. so much of what's there impacted the middle east we have today.
bearded_gnome 10 years ago
usually, this collumn doesn't wind up under OTS, but instead it is usually under "pulse" (what the LJW calls the 'living' section) once a week.
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text:
Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance
Version of Record online: 23 JUL 2010
DOI: 10.1111/j.1755-148X.2010.00744.x
© 2010 John Wiley & Sons A/S
Pigment Cell & Melanoma Research
Volume 23, Issue 5, pages 649–660, October 2010
Additional Information
How to Cite
Landsberg, J., Gaffal, E., Cron, M., Kohlmeyer, J., Renn, M. and Tüting, T. (2010), Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance. Pigment Cell & Melanoma Research, 23: 649–660. doi: 10.1111/j.1755-148X.2010.00744.x
Publication History
- Issue online: 1 SEP 2010
- Version of Record online: 23 JUL 2010
- PUBLICATION DATA Received 29 May 2010, revised and accepted for publication 15 July 2010, published online 23 July 2010
- Abstract
- Article
- References
- Cited By
- Melanoma;
- T cells;
- tumor immunity;
- genetically engineered mouse model;
- tumor microenvironment;
- immune evasion;
- myeloid suppressor cells
Genetically engineered mouse models offer new opportunities to investigate the role of cell-mediated immunity in the natural progression of melanoma in an immunocompetent host. Here we report that Hgf-Cdk4R24C mice spontaneously develop a spectrum of primary melanomas with high penetrance during their first year of life. Malignant transformation proceeds in a stepwise manner from multiple melanocytic nevi to single nodular melanomas and disseminated metastases in most mice. Migrating melanoma cells invade the draining lymph nodes without activating the immune system. Autochthonous primary tumors are destroyed following experimental introduction of immune surveillance using an adoptive lymphocyte transfer approach. However, some tumor cells are able to survive, evade immune cell control, and recur both locally and systemically. Immune tolerance in recurring tumors may be supported by immunosuppressive Gr1+ myeloid cells. Taken together, our results demonstrate that primary and metastatic melanomas developing spontaneously in Hgf-Cdk4R24C mice effectively evade cellular immune surveillance.


text:
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|By Marketwired .
Article Rating:
|January 23, 2013 08:00 AM EST
SUNNYVALE, CA -- (Marketwire) -- 01/23/13 -- Proofpoint, Inc. (NASDAQ: PFPT), a leading security-as-a-service provider, today announced its Winter 2013 release which delivers significant enhancements to the Proofpoint Enterprise suite of cloud-based threat management, regulatory compliance, information governance and secure communication solutions. Among the features and enhancements in the Proofpoint Winter 2013 release is a new cloud-based solution for secure, compliant file transfer, Proofpoint Secure Share.
"Rapid innovation enabled by the cloud is one of the primary drivers of strong adoption of the Proofpoint information security and governance suite," said David Knight, executive vice president of products for Proofpoint. "Our Winter 2013 release continues this innovation with the introduction of Proofpoint Secure Share, the third significant new module introduced to the Proofpoint Enterprise suite in the past three quarters."
Introducing Proofpoint Secure Share
Proofpoint Secure Share is a cloud-based, managed file transfer solution that makes it easy for end users to exchange large files securely -- and in compliance with enterprise policies such as data loss prevention rules -- without impacting the organization's email systems or other IT infrastructure. Proofpoint Secure Share is designed to simplify the process of exchanging large or sensitive files while also meeting the strict security and compliance requirements of today's enterprise. Benefits include:
- Highly-secure file sharing experience: Proofpoint Secure Share incorporates enterprise-grade security controls including sender/recipient authentication, encryption, malware detection and data management capabilities.
- Simple enforcement of file sharing policies, including data loss prevention: Proofpoint Secure Share allows administrators to easily customize and enforce a wide variety of file transfer policies for data retention and file management. Integrated data loss prevention (DLP) capabilities enable Proofpoint Secure Share to detect private, sensitive or confidential information in transferred files and help minimize data exposure risks.
- End-user ease of use: Proofpoint Secure Share allows users to exchange files using a convenient web-based interface or right from their Microsoft Outlook inboxes. Proofpoint Secure Share's seamless user experience increases end-user adoption, simplifies file transfer workflows and reduces the risks associated with employees using unsanctioned file sharing alternatives.
Proofpoint Secure Share provides enhanced security and administrative control over traditional file transfer methods, existing on-premises solutions, and public cloud file sharing services. Proofpoint Secure Share leverages the enterprise-class data loss prevention features of Proofpoint Enterprise Privacy suite to automatically enforce DLP rules such as blocking or encrypting sensitive content. Recipient authentication features protect confidential information and help ensure that only valid, verified recipients can receive sensitive files.
Each Proofpoint Secure Share file link is assigned a limited lifespan with an administrator-configurable expiration time. Flexible DLP options enable blocking and/or quarantining of files that violate enterprise policies, end-user notification and reporting features. Return receipts let end users confirm that their files were delivered, while an audit trail is maintained to provide file access tracking and reporting features. File recipients can easily respond and share large files with original senders via Secure Share's web-based user interface which also maintains an audit history of file sharing actions.
For an overview of the capabilities of Proofpoint Secure Share, see this brief video demonstration: http://www.proofpoint.com/secure-share-demo. In February, Proofpoint will host a webinar featuring Proofpoint Secure Share: http://www.proofpoint.com/id/webinar-q113-privacy/index.php?id=7.
Proofpoint Enterprise Protection, Targeted Attack Protection and Privacy Enhancements
The Proofpoint Winter 2013 release includes updates to Proofpoint's threat management and regulatory compliance capabilities. The Proofpoint Enterprise Protection email security solution incorporates enhancements including:
- Enhanced custom threat and spam definitions and classification rules: The latest version of Proofpoint Enterprise Protection gives administrators more control over threat classifications including phish, bulk mail, and adult content messages, enabling more granular handling of particular message types and improving overall effectiveness.
- The administrative interface for Proofpoint Enterprise Protection and Privacy is now available in English, Japanese, German and French versions, configurable on a per-administrator basis.
- Access to various components of the Proofpoint Enterprise administrative interface is now more granular, giving Proofpoint's, large multi-national customers precise control over the rights and permissions granted to individual administrators.
In addition, the Proofpoint Targeted Attack Protection solution -- which uses big data analytics and other advanced technologies to provide reliable protection against spear phishing and other malicious, targeted attacks -- continues to be enhanced with new threat detection techniques and advanced malware sandboxing features.
The latest version of Proofpoint Enterprise Privacy, which provides data loss prevention and policy-based email encryption capabilities, allows even more flexibility in creating customized DLP policies. The solution now includes more than 20 pre-defined lexicons and 35 "smart identifiers" (including a wide variety of international identifiers) to detect personal information, financial information and protected health information and address customer needs to comply with complex, global data protection regulations. Other updates include enhanced control over end-user enrollment for Proofpoint Encryption and new customization options for the Proofpoint Secure Reader web-based encryption interface.
Archiving and Information Governance Enhancements
The Proofpoint Enterprise Archive cloud archiving solution has been enhanced with a variety of administrative and end-user features including:
- New user interface localizations: The interface for Proofpoint Enterprise Archive now allows end users to select their preferred language from more than a dozen options including Chinese (Simplified or Traditional), Czech, English, French, German, Italian, Japanese, Polish, Russian, Spanish, Thai and Turkish.
- Delegated administration and discovery segmentation enhancements: Large organizations that use Proofpoint Enterprise Archive across a number of different business units, agencies or divisions can now limit administrator access to only those mailboxes within an administrator's scope of responsibility. This allows multi-division organizations to delegate mailbox administration to local IT staff while constraining those staff members to manage only those mailboxes within their division. Proofpoint Enterprise Archive's discovery segmentation features (which enable per-division searches and legal holds) are now available to Microsoft Office 365 customers.
- Enhanced legal discovery export capabilities: The latest version introduces a variety of enhancements to the workflow and capabilities around export of messages to PST or EDRM file formats.
- Availability of Content Collection option: The latest version includes support for the recently introduced Proofpoint Enterprise Archive Content Collection option, which extends Proofpoint's powerful eDiscovery and legal hold capabilities beyond email to a wide variety of documents. With the addition of the Content Collection option, Proofpoint Enterprise Archive provides a unified, secure and searchable legal hold repository of both files and messages.
Gartner positions Proofpoint in the Leaders Quadrant of its recently published 2012 Magic Quadrant for Enterprise Information Archiving. Read the full report, compliments of Proofpoint, at http://www.proofpoint.com/email-archiving-magic-quadrant.
About Proofpoint, Inc.
Proofpoint Inc. (NASDAQ: PFPT) is a leading security-as-a-service provider that focuses on cloud-based solutions for threat protection, compliance, archiving & governance and secure communications. Organizations around the world depend on Proofpoint's expertise, patented technologies and on-demand delivery system to protect against phishing, malware and spam, safeguard privacy, encrypt sensitive information, and archive and govern messages and critical enterprise information. More information is available at www.proofpoint.com.
Proofpoint, Proofpoint Enterprise Protection, Proofpoint Enterprise Privacy, Proofpoint Encryption, Proofpoint Secure Share, Proofpoint Enterprise Archive, Proofpoint Enterprise Governance and Digital Thread are trademarks or registered trademarks of Proofpoint, Inc. in the U.S. and other countries. All other trademarks contained herein are the property of their respective owners.
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Orlando DeBruce
Proofpoint, Inc.
[email protected]
Lisette Paras
Ogilvy Public Relations
[email protected]
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8 brilliant GIF artists you need to know about
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Warrens Village, Clevedon
- Free WiFi in lobby and free parking
Main amenities
- 70 smoke-free accommodations
- Restaurant and 2 bars/lounges
- Breakfast available
- Limo/town car service
- Arcade/game room
- Self-serve laundry
- Meeting room
- Limited hour front desk
What's around
- Clevedon Court (2.1 mi / 3.4 km)
- Noah's Ark Zoo Farm (6.4 mi / 10.2 km)
- Clifton Suspension Bridge (12.5 mi / 20.1 km)
- Cheddar Gorge and Caves (13.5 mi / 21.7 km)
- Bristol City Museum and Art Gallery (13.8 mi / 22.3 km)
Warrens Village, Clevedon
Hotel Info: 866-539-8117from $56
- Superior Double Room, Ensuite
- Twin Room
- Chalet, 2 Bedrooms
- Double Room, Ensuite
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 70 rooms
- This hotel is arranged over 1 floor
- Check-in time 3 PM-10 PM
- Check-out time is 10:00 AM
- Express check-in/out
If you are planning to arrive after 2 PM please contact the property in advance using the information on the booking confirmation.
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
- Minimum Spring Break check-in age is 18
Travelling with others
- No cribs (infant beds)
- No pets or service animals allowed
- Free WiFi in public areas
- Free self parking
- Extended parking *
Other information
- Smoke-free property
Nearby Two Star Clevedon hotels
In the hotel
- English breakfast daily (surcharge)
- 2 bars/lounges
- Restaurant
- Fishing on site
- Golf lessons available nearby
- Golfing nearby
- Hiking/biking trails nearby
- Kayaking nearby
- Sailing nearby
- Arcade/game room
- Billiards or pool table
- One meeting room
- Front desk (limited hours)
- Limo or Town Car service available
- Laundry facilities
- Number of buildings/towers - 100
- Year Built 1981
- Accessible bathroom
In the room
- Coffee/tea maker
- Private bathroom
- Shower/tub combination
- Desk
- Refrigerator
- Weekly housekeeping provided
Top Clevedon hotels
Recently reviewed hotels in Clevedon
- Hotel One Hundred - Bed & BreakfastFrom
"The hotel is a 3 floor house, turned hotel or B&B. We had Room 2 on the top floor facing the street. The room was spacious, a bit noisy from the street traffic with Two flights of…"May 12, 2016
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"Beautiful new hotel built in the style that completely blends in with city's architecture. Large and nicely appointed rooms with luxiutious bedding, excellent spa, very convinient…"May 12, 2016
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Nearby hotels
Special features
DiningAngelinas - This restaurant serves breakfast and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Warrens Village, Clevedon's small print
This property's policy is to refuse certain bookings for the purpose of group events or parties, including pre-wedding stag/bachelor and hen/bachelorette parties.
Noise-free guestrooms cannot be guaranteed.
Only registered guests are allowed in the guestrooms.
This property does not have elevators.
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Optional extras
Onsite credit card charges are subject to an extra charge
Extended parking is available for an extra charge
English breakfast is offered for an extra charge of GBP 5.50 for adults and GBP 2.75 for children (approximately)
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


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Ringo Lam
|Highest Rated:
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|Lowest Rated:
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|Not Available
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|"No money, no time; just do it." So goes the Nike-esque philosophy of one of Hong Kong's most well-known and notorious filmmakers. With a firm grasp on the fast-paced expectations of the Hong Kong film industry, a reputation for having a quick temper, and a tyrannical on-set directorial style, Ringo…


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Google Inc
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United States
Google Inc. maintains an index of Websites and other online content, and makes this information freely available through its search engine to anyone with an Internet connection. Its automated search technology helps people obtain nearly instant access to ... more
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ICL Group
Steven Suissa
SHS Services LLC
Jerry Suissa
National Renewable Energy Laboratory


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who is that guy
Mirraco Must See: 2012 Preview 5
Take an inside look at Mirraco's 2012 complete bikes and Black Label parts line along with some bonus riding footage from Lennie Westfall.
rwg2008 9/8/2011 1:19 AM
5 comments newest first
lennie isn't on the team you idiot
The Guys on the team just keep getting worse, Maybe mirra will get his head out of his ass and get involved in the company
Yeah Lennie!
cant stand the brake honk style.


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This website is designed to provide a forum where church board chairs can ask questions, share experiences and ideas, and locate helpful resources.
Click on the list of articles below or search via the search box above.
Leadership Manual
Download the Church Board Chair Leadership Manual written by Dr. Perkins. Cost $10.00.
Key Wordsaccountability » board conduct » Board dynamics » board education » Board Governance » church board chair » Church board leadership » church boards » Effective Church Boards » leadership » lead pastor » senior pastor
Article Categories
- Board (286)
- Board Chair (293)
- Board Governance (286)
- Board Member (276)
- Book Reviews (9)
- Case Study (3)
- Church (4)
- Congregation (4)
- Senior Pastor (229)
Church Board Related Sites
Favorite Websites
Recommended Reading
Resources on Board Governance
Yes, it's time! For too long church board chairs have laboured without much help or many resources. Struggling valiantly chairs work diligently, but often feel overwhelmed by complexity, adversarial relationships, uncertain expectations, and the lack of a road map. Yet, you do this work because you believe in the mission of Christ's church. Recent developments in non-profit governance continue to influence how church board's understand their role, particularly within larger church settings. Whether it is the Carver "Policy Governance" model, or another paradigm, the chair's role also is being re-conceived and re-positioned within church leadership structures. In this website I seek to provide a forum for introducing, evaluating, and biblically situating such developments and also providing some resources so that you as a church board chair can find your bearings in all of these matters.
293. The Power of Regular Board Policy Reviews.
In one sense policies are the nerve system of a church board. Good policies let the board know when something is not working properly. They sensitize board members both to good and bad direction. They warn about imminent danger and … (read the rest)
292. Handling the Emotional 'Pitch'.
Many different issues appear on a church board's agenda, but some carry with them a particular emotional nuance. This added element may arise because of the moral nature of the issue or the passion with which a group in the … (read the rest)
291. When is it time to change Church Board Structure and Operations?
Churches, as organizations, tend to preserve their operational processes and resist change. I think this is the case particularly for churches whose congregations number between 100 and 500. Leaders get used to the "tried and tested" patterns. If suggestions for … (read the rest)
290. Building an Engaged, Effective Church Board: Who is Responsible? # 3
In related blog articles #288 and #289 I have considered the role of a church board chair and church board members in developing an engaged, effective church board. In addition, we must also think carefully about the role of a … (read the rest)
289. Building an Engaged, Effective Church Board — Who is Responsible? #2
Board members…what do they contribute to building an engaged, effective church board? In one respect the very possibility of a church board functioning in an engaged, effective manner depends totally upon the cooperation and motivation of individual board members. If … (read the rest)


text:
Channel Sponsor - Coding/Billing/Collections
Sponsored by National Medical Billing Services | firstname.lastname@example.com | (636) 273-6711
4 Benefits of ICD-10 for Physicians
In a Medscape Today report, Elizabeth Woodcock, founder and principal of Woodcock & Associates, which focuses on medical group operations and revenue cycle management, lays out four benefits that ICD-10 may offer for physicians.
The four benefits of ICD-10 are:
1. Coding is more specific.
2. Finding a possible diagnosis is easier.
3. The description of the extent of diagnoses is improved.
4. It's easier to assign codes.
More Articles on Physicians:Report: 10 Specialties With the Most Medical Malpractice Lawsuits
Team Physician Consensus Statement Gets 2013 Update
66% of Physicians Believe Physician-Hospital Integration Will Increase
© Copyright ASC COMMUNICATIONS 2016. Interested in LINKING to or REPRINTING this content? View our policies by clicking here.
To receive the latest hospital and health system business and legal news and analysis from Becker's Hospital Review, sign-up for the free Becker's Hospital Review E-weekly by clicking here.
Latest Articles
- CDC pleads Congress to approve Zika funding quickly — 6 observations
- Will the bronze plan disappear soon? 4 takeaways
- WHO reports nearly 600 healthcare attacks in 19 countries — 6 things to know
- Is the VA lacking resources or funding less critical areas? 6 insights
- Dr. Kenneth Chang performs 1st TIF procedure using new EsophyX Z device: 6 things to know


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Photo SpecialReal-Life Celebrity Heroes
From David Beckham to Prince Harry, meet 19 stars whose real-life heroics make headlines
Credit: Elder Ordonez/INF
Updated: Tuesday Apr 02, 2013 | 12:00 PM EDT By: Michael Y. Park
More from PEOPLE
Latest News!
- Bellissimo! Jennifer Lawrence Goes Sightseeing in Italy with Aziz Ansari Ahead of Her Best Friend's Wedding
- Read the Cover Story: Steve Harvey: From Homeless to Having It All
- FROM EW: X-Men TV Show Starring Dan Stevens Is Officially Happening
- Court Papers Reveal Just How Much Money Amber Heard Made Last Year
- FROM EW: Harry Potter Star Matthew Lewis Remembers Alan Rickman


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Today, it's world-renowned as a high-end clothing label with an insatiable love of zigzags, luxe knit fabrics, and geometric shapes — but Missoni actually started from very humble beginnings. Founded in the 1950s by Italian husband-and-wife team Ottavio and Rosita Missoni, the company began as a basement studio workshop anchored by two knitting machines and a collection of ideas. Word about Missoni's bold, innovative patterns gradually spread among the fashion-following public — eventually reaching legendary Vogue editor Diana Vreeland, who promoted the brand in the pages of her magazine. Missoni's super-stylish footwear complements its dresses, pants, and M Missoni collection by reproducing the iconic zigzag and chevron motifs on flat espadrilles, crochet-paneled wedges, embroidered peep-toe booties, and sky-high heels. Looking for something subtler? Try Missoni's combat boots in basic brown suede, or white striped canvas sling-backs with lace-up fronts.
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Bravo's band changing rules of international game
Apr 7, 2016: If the premier West Indies cricketers are to be solely known for their T20 skills, will the regional Test side remain relevant anymore?
A pitch destroyed, a club renewed
Mar 24, 2016: Melbourne's Kingsville Baptist CC had their pitch vandalised ahead of a vital game. Their graceful response has won many admirers for a club that reflects the changing face of Australian cricket
Australia's reversal of fortune
Feb 26, 2016: For years, they were seen as being slow on the ball on reverse swing. Not so in the New Zealand series
Holder and de Villiers have warned us
Jan 15, 2016: When two Test captains are sending similar messages about the direction of the game, cricket must know it has a problem on its hands
Why we need a Test championship series
Nov 20, 2015: The idea of a battle for the world No. 1 spot in the top format may have been shelved, but its absence is sorely felt
Australia's board and player association need to talk
Oct 27, 2015: The vast pay disparity between the men and women cricketers is just one issue that could be addressed if there was a more fruitful relationship between CA and the players' body
How not to run a cricket ground
Sep 10, 2015: In contrast to its thrilling on-field narrative, the administrative story of the WACA is one of mismanagement and confused vision
Michael Clarke's retirement
Clarke's a career ever so near to greatness
Aug 19, 2015: Michael Clarke will be remembered as a great cricketer and as a fascinating, occasionally infuriating, but forever driven man
ICC news
The plot thickens for world cricket
May 1, 2015: The game is undoubtedly entering a new period of volatility, as positions of power and influence start to shift, either by accident, design or a little of both
Australia news
Nov 26, 2014: Going out to play cricket today would have been near enough to impossible. Even doing so next week in the nets and at the Gabba for the first Test will be difficult
Empower the ACSU to clean up T20
May 18, 2014: An independent ACSU must be allowed to pursue its own investigations and impose penalties if the game's custodians are serious about stamping out corruption in T20 leagues
Australia in England 2013
Fawad's choice opens cultural faultlines
Sep 6, 2013: Hurried in as the legspinning saviour of Australian cricket, Fawad Ahmed's choice to not wear the Australian shirt bearing their beer-company sponsors has sparked a wider debate on immigration
ICC World Cup 2015
Jul 30, 2013: The prefabricated surfaces prepared for 2015 are a case of character being traded for cash flow
Australia news
Arthur let down by coach-killers
Jun 25, 2013: Australia's problematic cricketers overwhelmed Mickey Arthur, just as they did his former assistant Lachlan Stevens last summer
May 7, 2013: Tim May's removal from the ICC cricket committee maintains the eclipse of the outspoken at the governance table
Australia's quest for a leader
May 1, 2013: The most significant leadership appointment of their winter tours to England may not have been for the Ashes
Cricket Australia contracts 2013-14
Test players deserve CA contract security
Apr 3, 2013: In its current form, Australia's list of central contracts will only push young players away from Tests and towards T20 as the source of their security
Australia news
Starc right to call Warne's bluff
Dec 11, 2012: In defending team-mates Nathan Lyon and Ben Hilfenhaus from perceived criticism, Mitchell Starc showed his heart is in the right place
Australia in England 2012
Australia need Clarke at No. 3
Jul 4, 2012: Michael Clarke is Australia's most accomplished and fluent ODI batsman - he should be setting the agenda at the top of the order
The facts of Ponting's ODI life
Feb 21, 2012: In the manner of his departure from ODIs, he has mirrored the relentless and single-minded way in which he played them. No fluff, just facts
The nervous 9990s, and 11-county Test XIs
Ask Steven: How many debutant bowlers have taken two Test wickets before conceding a run?
Kartikeya Date: Is Kohli as good at T20 as he is cracked up to be? And did the better bowling side win this year's title?
England's guardian joins 10K club
Mark Nicholas: The youngest of a bloody-minded dozen, Alastair Cook was marked out for greatness more than a decade ago - and there is still more to come
Luke Alfred: As Mickey Arthur takes charge of Pakistan, he could do worse than look back at his successful tours of England and Australia in 2008
Why runs per Test is an excellent measure for consistency
Anantha Narayanan: A study of match runs often gives a clearer picture of how well a batsman has done over a period
Morris and Mustafizur, Krunal and Chahal in IPL XI (76)
Who makes it to the IPL XI for 2016? Here are ESPNcricinfo's picks, keeping in mind the four-overseas-players rule
Leaden Mathews leads SL nowhere (37)
Far from a towering, inspiring, regal presence, Angelo Mathews just stood and watched as England steamrolled his side once again
England's guardian joins 10K club (37)
The youngest among a bloody-minded dozen, Alastair Cook was marked out for greatness more than a decade ago - and there is still more to come
IPL slump costs Hardik and Negi (32)
Poor form in the IPL, and the selectors' decision to reward consistent domestic performers such as Faiz Fazal and Yuzvendra Chahal, resulted in the omission of Hardik Pandya and Pawan Negi for the Zimbabwe tour
A record-breaking year, but no title for RCB (26)
Led by the batting feats of Virat Kohli and AB de Villiers, Royal Challengers Bangalore overcame a poor start to the season and went all the way to the final, only for their bowling weaknesses to resurface


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LivingSocial is running Black Friday and Cyber Monday deals from brands such as Verizon, Office Max, Skechers, The New York Times, FTD, and Wine.com. The daily deals company will pitch nine offers on Friday that will be live throughout the weekend, while 15 more discounts will be available on Monday.
Retailers involved with the promotions are offering 50 percent discounts with the exception of FTD, which is running a $15-for-$35 voucher (57 percent off). Subscriptions-based offers by New York Times, Hearst Magazines, and ShopRunner each hover around 60 percent discounts.
If comScore data from 2010 is any indication, LivingSocial may experience a sizable Cyber Monday haul. Online sales broke the $1 billion mark last year for the first time ever, the research firm said.
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