text:
|Publication number
|Publication type
|Application number
|Publication date
|Dec 14, 2010
|Priority date
|Jul 8, 2003
|Fee status
|Also published as
|Publication number
|Jens Jensen, Joseph A. Helpern, Glyn Johnson, Ramesh Chandra
|Original Assignee
|New York University
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (8), Non-Patent Citations (32), Classifications (9), Legal Events (2)
|External Links: USPTO, USPTO Assignment, Espacenet
The present application is a continuation of U.S. patent application Ser. No. 10/564,697 filed Jan. 11, 2006 now U.S. Pat. No. 7,667,459 (the "697 Application"), which is U.S. National Phase of PCT Application No. PCT/US2004/022163 which was filed on Jul. 8, 2004 and published in English on Jan. 27, 2005 as International Publication No. WO 2005/008259 (the "International Application"). The present application also claims priority from U.S. Patent Application No. 60/485,502, filed Jul. 8, 2003 (the "'502 Application"). The entire disclosures of these applications are incorporated herein by reference. This application claims priority from the '697 Application pursuant to 35 U.S.C. §120, from the International Application pursuant to 35 U.S.C. §365, and from the '502 Application pursuant to 35 U.S.C. §§119(e) and 365.
The present invention relates to methods, systems, software arrangements and storage medium for measuring a magnetic field correlation function in a magnetic resonance imaging area, and more particularly, to methods for measuring the magnetic field correlation ("MFC") function utilizing asymmetric spin echoes.
A theory of using asymmetric spin echoes is described, in part, in Jensen J. H. et al. Chandra R. Magn Reson Med; 44:144 (2000) (the "Jensen Publication"), the entire disclosure of which is incorporated herein by reference.
The local magnetic field experienced by a water proton is quantitatively characterized by the magnetic field correlation function, K(t), which may be defined by
Although it is believed that the MFC has not been specifically measured, it was introduced at least as early as 1953 in the seminal work of Anderson and Weiss on NMR line shapes. See Anderson P W, Weiss P R, Rev Mod Phys 1953; I25:269-276 (the "Anderson Publication"), the entire disclosure of which is incorporated herein by reference. More recently, it has been utilized in several studies on the modeling of MRI contrast. For example, see Callaghan P T, Oxford University Press, New York, 1991; (the "Callaghan Publication") Kennan et al., Magn Reson Med 1994; I31:9-21 (the "Kennan Publication"); Stables et al., Magn Reson Med 1998; I40:432-442 (the "Stables Publication"); and the Jensen Publication et al., the entire disclosures of which are incorporated herein by reference.
The MFC may be described as the magnetic resonance ("MR") signal intensity as a function of the acquisition time, and can be approximated by the exponential form:
K(t)=K 0 exp(−t/τ), [2]
where K0=K(0) is the magnetic field variance and τ is a characteristic decay time. It has recently been shown in the Jensen Publication, that when water diffusion is only weakly restricted the MFC is more accurately described by an algebraic expression of the form:
There is not a significant amount of quantitative information regarding the MFC, except for an exact result that can be derived for an idealized random sphere model.
Asymmetric single spin echoes were first introduced by Dixon and Sepponen. In particular, Dixon demonstrated how asymmetric spin echoes can be used to separate the MR signals originating from water and fat. See Dixon W T, Radiology 1984; I153:189-194 (the "Dixon Publication"), the entire disclosure of which is incorporated herein by reference. Sepponen et al., applied asymmetric spin echoes to obtain chemical shift images. See Sepponen R E, et al., Comput. Assist. Tomography 1984; I8:585-587 (the "Sepponen Publication"), the entire disclosure of which is incorporated herein by reference. The asymmetry of the Dixon sequence arises by shifting the signal acquisition time, while the asymmetry of the sequence of Sepponen et al. is achieved by shifting the 180° refocusing pulse.
Asymmetric single spin echo technique with a shifted refocusing pulse has been previously used to obtain MFC data. See Wismer et al., J Comput Assist Tomography 1988; I12:259-265 (the "Wismer Publication"); Rosenthal et al., Invest Radiology 1990; I025:173-178 (the "Rosenthal Publication"); Thulborn et al., Am J Neuroradiol. 1990 (the "Thulborn Publication"); 11:291-297; Hoppel et al., Magn Reson Med 1993; I30:715-723 (the "Hoppel Publication"); Ganesan et al., J. Magn. Reson. (B) 1993; I102:293-298 (the "Ganesan Publication"); and the Stables Publication, the entire disclosures of which are incorporated herein by reference. However, there remains a need for improved methods of measuring the magnetic field correlation.
The present invention relates to methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function, and more particularly, to methods, systems, software arrangements and storage medium measuring the magnetic field correlation function utilizing asymmetric spin echoes.
In an exemplary embodiment of the present invention, method, systems, software arrangements and storage medium obtaining the magnetic field correlation ("MFC") of a sample using magnetic resonance for imaging ("MRI") are provided that apply multiple spin echo sequences in which at least one spin echo sequence is an asymmetric spin echo sequence. Resultant information may then be acquired and the MFC can be determined as a function of the acquired information.
In a further exemplary embodiment of the present invention, the spin echo sequences may be an Asymmetric Dual Spin Echo Sequence ("ADSE") having multiple echoes. In another exemplary embodiment of the present invention, the spin echo sequences may be an Echo Planar Imaging-Asymmetric Dual Spin Echo Sequence ("EPI-ADSE") having multiple echoes.
In a further embodiment of the present invention, the asymmetric spin echo sequence can be applied by shifting a refocusing pulse such that the time between the rotation pulse and the refocusing pulse (t1) is not equal to the time between the refocusing pulse and the signal acquisition (t2), e.g., t1≠t2. In yet another exemplary embodiment, the asymmetric spin echo sequence may be applied by shifting the acquisition of the resultant information such that the time between the rotation pulse and the refocusing pulse (t1) is not equal to the time between the refocusing pulse and the signal acquisition (t2), i.e., t1≠t2.
In a further exemplary embodiment, the MFC can be determined as a function of the resultant information by applying the formula
in which γ is the proton gyromagnetic ratio, Sn is the signal intensity of the nth echo; and ts=|t1−t2| with t1 being the time between a rotation pulse and a refocusing pulse, and t2 being the time between the refocusing pulse and a signal acquisition.
Other and further objects, features and advantages of the present invention will be readily apparent to those skilled in the art upon a reading of the description of preferred embodiments which follows.
The present invention relates to methods, systems, software arrangements and storage medium for measuring the MFC function, and more particularly, to methods, software arrangements and storage medium for measuring the MFC function utilizing asymmetric spin echoes.
Since the MFC is sensitive to the spatial distribution of microscopic magnetic field inhomogeneities, MFC imaging enables another way to probe tissue microstructures. For example, MFC imaging may be potentially useful for evaluating tissues with substantial intrinsic microscopic magnetic susceptibility variations. It may therefore be used as a sensitive probe of tissue microstructure that provides certain information beyond what is contained in the standard nuclear magnetic resonance ("NMR") relaxation times, such as T2 and T2*. In addition, microscopic susceptibility variations can be created by the introduction of a contrast agent. For example, the contrast agent may be a paramagnetic element, e.g., gadopentetate dimeglumine (Gd-DTPA). Therefore, the imaging of the MFC may be useful in the evaluation of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, since ferritin (i.e., the most prevalent form of iron in the brain) is paramagnetic and localized in oligodendrocytes, which have diameters of about 7 μm. Indeed, it is known that the T2 relaxation rate, as measured with a Carr-Purrcell-Meiboom-Gill (CPMG) sequence, depends significantly on the interecho time in the brain region. Thus, the MFC with a nontrivial time dependence may be expected and the measurement of this time dependent MFC can provide a significant marker of disease state.
The MFC imaging may be of particular interest for Alzheimer's disease, as conventional relaxation time measurements may not be as useful. Another possibly important application the MFC imaging may be to the imaging of tumors. Most paramagnetic contrast agents, such as Gd-DTPA, enter only the extra cellular spaces of tissues, and thereby create microscopic magnetic susceptibility variations. The MFC of a contrast agent infused tumor may be sensitive to tumor morphology (e.g., cell size and density). The measurement of the MFC can therefore assist in tumor identification and grading. Moreover, measuring the MFC with the magnetic resonance imaging ("MRI") may be a preferable way for probing inhomogeneities on a length scale of a few tens of micrometers. This may be because MRI echo times are typically in the range of 10 ms to 100 ms, and the water diffusion constant in biological tissues is about 1.0 μm2/ms. This implies that the temporal behavior of the measured MFC may be sensitive to spatial variations in the range of 8 μm to 25 μm. Biologically, this may be an important length scale, since this is the size of capillaries and many types of cells.
The MFC may be defined as the product of the magnetic field shifts experienced by a water molecule at two different times, averaged over all the water molecules within a specified region of interest. The field shifts may be the differences between the magnitude of the field and the magnitude of the uniform background field (which may be nearly the same as the external field magnitude). If the biological tissue has linear magnetic characteristics, as is usually the case, then the MFC may vary as the square of the external field. The dependence of the MFC on the difference in the two sampling times, on the other hand, may be purely an intrinsic tissue property. In practice, the MFC may be most sensitive to the spatial dependence of the field shifts over length scales of about 10 μm, which is comparable to the size of many cell types.
To appreciate the significance of the MFC, it is preferable to understand the definition of the MFC, which is provided as follows. For example, a tissue may be exposed to a strong, uniform external magnetic field, as is the case in a typical MRI experiment. Because of spatial variations in its magnetic susceptibility, the tissue may generate an inhomogeneous secondary field. The susceptibility variations can be provided due to structures such as iron-rich cells or vessels with a deoxygenated blood. A water molecule diffusing through the tissue may experience a field that varies with time due to field inhomogeneities. If δB(t) is defined as the difference at time t between the magnitude of the field at the water molecule and the uniform background field, then the MFC may be defined by
As an illustration,
According to one exemplary embodiment according to the present invention, the MFC at specific times can be directly imaged without recourse to any particular model. This exemplary technique thereby yield information beyond what may be provided by conventional relaxation time measurements. The fact that the MFC contains information distinct from T2 and T2* can be described using the following simple example. For example, two test tubes, A and B, can be provided each containing an aqueous suspension of microspheres and equal concentrations of a paramagnetic contrast agent. If the microspheres in test tube A have a radius of 10 μm and the microspheres in test tube B have a radius of 20 μm, the spatial density of spheres in test tube A can be eight times higher than in test tube B. The volume fraction filled by the spheres can then be approximately the same in both suspensions. T2 can be the same for both test tubes because T2 can be determined primarily by the contrast agent concentration. T2* can also be essentially the same, because T2* may depend primarily on the contrast agent concentration and the volume fraction of the spheres. Therefore, the test tubes may appear approximately identically on T2 or T2* weighted images. However, if a water diffusion constant of 1.0 μm2/ms is assumed, then for a time difference of 20 ms the MFC values for the two test tubes will differ by about a factor of two, and the test tubes may appear sharply different on an MFC image.
A relationship between the MFC and transverse relaxation rates may be most clearly revealed through a connection between the MFC and T2 as measured with a Carr-Purcell-Meiboom-Gill (CPMG) sequence. Because of water diffusion through field gradients, the measured T2, as obtained from a monoexponential fit to the echo intensities, may depend on the interecho time, 2Δt. In the limit 2Δt→0, the true T2 value may be obtained. If the magnetic field inhomogeneities are not too large, then one can show that T2 as a function of Δt may be provided by
with γ representing the proton gyromagnetic ratio.
If the full dependence of T2 on the interecho time were available, then it is possible to invert Eq. [5] to determine the MFC. However, it is generally only practical to obtain T2 for a limited number of Δt values, and so a straightforward inversion may not be possible. In some cases, it may be possible to postulate a model form for the MFC, having a few adjustable parameters, and then fit the model to the T2 data by using equation [5]. However, the success of this approach may depend on the accuracy of the model, which can be difficult to establish.
The physical significance of the MFC can be twofold. First, the magnitude of the MFC may provide a measure of the amplitude of the magnetic field inhomogeneities within a tissue. In particular, as follows from Eq. [3], K(0) can be the variance of the field. Second, the decay of the MFC with time may contain information about the spatial variation of the field inhomogeneities. In particular, the temporal rate of change of the MFC at a time t (i.e., K′(t)) can be primarily sensitive to field inhomogeneities with a length scale of about √{square root over (6Dt)}, where D is the water diffusion constant, where √{square root over (6Dt)} being the average distance a water molecule diffuses over a time t. Thus, the MFC may be measured in conjunction with diffusion-weighted imaging (DWI) in order to obtain an estimate of the water diffusion constant. This additional information may then allow for a more accurate assessment of the length scale associated with the field inhomogeneities. If the inhomogeneities vary only on length scales that are large compared to about √{square root over (6Dt)} (i.e., >>25 μm), the MFC can be essentially independent of time and may be related to the NMR line width. Particularly, the second moment of the NMR spectral line may be approximately about 4γ2K.
According to an exemplary embodiment of the present invention, the MFC may be determined by applying 2 or more spin echo sequences, in which at least one spin echo sequence is an asymmetric spin echo sequence.
where γ is the proton gyromagnetic ratio.
Equation [6] is based on a weak field approximation, but is also usable at clinical field levels of a few Tesla or less. The correlation function enters equation [6] preferably only for times between t−ts and t+ts. If K(t) is approximated in this temporal range by a linear function, the following formula may be applied:
Hence, the ratio of the signal intensities for a standard spin echo sequence and for an asymmetric spin echo sequence can be used to estimate K(t) at a selected time. This exemplary technique may be utilized for multiple spin echo sequences so that K(t) at several different times may be determined from one pair of acquisitions.
For example, the key may be a relationship between the MFC and the signal intensity for an asymmetric CPMG sequence. The asymmetric CPMG sequence differs from a conventional CPMG sequence in that the 180° refocusing pulses are shifted from their usual times by an amount ts, as is illustrated in
with the convention S−1(ts)=1. The corrections to equation [8] are preferably third order in the field, and for weak fields are small compared to the MFC, which is second order in the field. The integral in equation [8] is over the time t ranging from −ts to ts. As long as ts is not too large, it is reasonable to make the following linear approximation:
K[(t+2n−1)Δt]≈K[(2n−1)Δt]+tK′[(2n−1)Δt] [9]
which leads to the following simplification:
This expression indicates that the MFC at the time of the nth refocusing pulse can be estimated from the signal intensities of the preceding and succeeding echoes. As provided in equation [10], an echo train of N echoes can be used to obtain the MFC at N different times.
As an example of how to apply equation [10] to obtain an estimate for the MFC, the experiment described in Wismer may be considered. See Wismer et al., J Comput Assist Tomography 1988; I12:259-265, the entire disclosure of which is incorporated herein by reference.
1n[S 1(t s)]≈1n[S 1(0)]−2γ2 t s 2 K(Δt). [11]
Thus, the signal intensity is preferably a linear function of ts 2 on a semi-logarithmic plot. An estimate of the MFC at the time of the refocusing pulse can then be found from the slope of a line fitted to the data. In
Qualitatively similar behavior for the signal intensity as a function of ts has been reported for normal brain, bone marrow, lung tissue and microsphere phantoms. See the Hoppel, Rosenthal, Ganesan., and Stables Publications.
Referring to
One of the features of the present invention is the use of the RF pulse sequence. Referring to
According to one exemplary embodiment of the present invention, two pulse sequence programs implementing an ADSE may be used. A dual spin echo has the advantage over a single spin echo by simultaneously providing the information usable to estimate the MFC for two different time values. In one exemplary embodiment of the present invention, a conventional sequence with a single phase encoding step for each 90° radio frequency (RF) pulse may be used. For example, the sequence shown in
Using the exemplary techniques described in the present invention, the MFC may be estimated by applying equation [7] to the ADSE imaging data. For example, typical MFC values obtained in vivo for a human brain are using the methods and systems according to the present invention listed in Table 1. One prior in vivo human study, which allows for MFC estimates, gives data just for hemorrhagic brain lesions, which have a much higher MFC than healthy brain tissue. See Wismer Publication. This study, however, has been performed at a low field level of 0.6 T, and the MFC in normal brain was presumably too small to observe due to a small SNR. Since the MFC increases quadratically with the field strength, the MFC at 1.5 T is 6.25 times larger than at 0.6 T, its detection is easier.
Brain Region
Mean MFC (1/s2)
Globus Pallidus
1004 ± 112
Substania Nigra
820 ± 92
Red Nucleus
715 ± 75
497 ± 83
Caudate Head
443 ± 73
318 ± 100
Cortical Gray Matter
268 ± 95
Frontal White Matter
150 ± 104
Therefore, the exemplary embodiment of the system process and software arrangement according to the present invention is well-adapted to carry out the objects and attain the ends and advantages mentioned as well as those which are inherent therein. While the invention has been depicted, described, and is defined by reference to exemplary embodiments of the invention, such a reference does not imply a limitation on the invention, and no such limitation is to be inferred. The invention is capable of considerable modification, alteration, and equivalents in form and function, as will occur to those ordinarily skilled in the pertinent arts and having the benefit of this disclosure. The depicted and described embodiments of the invention are exemplary only, and are not exhaustive of the scope of the invention. Consequently, the invention is intended to be limited only by the spirit and scope of the appended claims, giving full cognizance to equivalence in all respects.
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|Western Atlas International, Inc.
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|U.S. Classification
|324/309, 324/307
|International Classification
|Cooperative Classification
|European Classification
|Feb 22, 2010
Owner name: NEW YORK UNIVERSITY, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JENSEN, JENS;HELPERN, JOSEPH A.;JOHNSON, GLYN;AND OTHERS;SIGNING DATES FROM 20060105 TO 20060109;REEL/FRAME:023971/0247
|May 14, 2014
|Fee payment
Year of fee payment: 4


text:
Tags » Lola
Wanting Out
I should want to be conservative
People watch me
Its my fault people are looking
Being myself is what causes me pain
I care too little about what others think I should care more for… 139 more words
Tiger Mum, Orangutan Dad
Over the past fortnight I've received a couple of comments about my endeavours to expedite ten month old Mina's development. Last week I wrote about how she has just learned to crawl… 871 more words
C a r e l e s s l y
So carelessly we run around,
Handing out love, our pride,
Our moments in life
To someone else.
We are em-joyed…
(Empowered with joy)
We mark them as the source and cling to them… 136 more words
My best poems come from anything and everything. Often a quote, a memory, or a song catches my attention and starts me musing, then writing about it.
How sweet and lush then,
Are the sounds of the choir
Composed of my feathery companions
The amazing scent of lilac and rosemary,
Mingle with the view of the tilted cherry tree… 85 more words
On Broken Rocks
On broken rocks along the shoreline
where the caves of storm nymphs hold scattered remains
of every sunken ship,
there walks Adam's Lilith—
Collier's too— 88 more words

subset: commoncrawl


text:
I am creating an instance of AxWebBrowser in a win forms app because I need it to render flash. How can take a screenshot of the page it's rendered in C#?
Cant you just use
.. obviously with the dimensions etc of your window? Never tried it but I cant imagine why it wouldnt work.


text:
*Her famous photobombing brother Peter may have been her date for the Oscars, but Lupita Nyong'o is reportedly romantically involved with Somali rapper K'Naan, according to Radar Online.
Paps caught the pair Monday morning, with K'Naan holding her best supporting actress Oscar for "12 Years a Slave."
Born Keinan Warsame in Somalia, K'Naan fled with his family to Canada in the 90s after seeing his young friends killed in the beginning of that country's civil war, according to the website. But life in North America would only prove to be more dangerous. In a tough Toronto neighborhood, K'Naan fell in with a Somali gang.
"We Somalis weren't treated well because we didn't know how to dress cool," he's explained. "We didn't have Nike trainers; instead, we had stuff from Walmart and kids would be laughing. There was always conflict there …"
Ultimately, he would be arrested more than a dozen times during his teen years, according to multiple reports, including at least once for violence involving a firearm.
"I learned to fire guns at the age of nine or so," he's revealed, "but luckily [I] was not out killing people. We zigzagged the streets to escape those trying to kill us."
Now a successful rapper — and a devout Muslim who does not drink or smoke —K'Naan has drawn criticism in recent years for his stance on Somali pirates like those featured in "Captain Phillips": He says they're "serving a purpose."
Citing illegal fishing and the dumping of toxic waste off the coast of Somalia, he's said, "Our pirates were the only deterrent we had from an externally imposed environmental disaster. One man's pirate is another man's coast guard."
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text:
Somerset Art Weeks Festival 2015
Goodbye to Somerset Art Weeks 2015!
It's a been a fantastic Somerset Art Weeks Festival.
We would like to thank all individuals and organisations for their support. Our special thanks of course to the participating SAW artist members, their effort and hard work makes the festival possible. If you want to receive information about our next event, please sign up to our mailing list.
About the Festival
Somerset Art Weeks Festival 2015 is an event which supports the development of the artistic community as a fundamental part of the economic life of the county. It showcases a broad-ranging programme of contemporary visual arts and craft, featuring group shows, new commissions, projects and events in 116 locations across Somerset. It encourages visitors to gain first-hand experience of contemporary arts in Somerset. This year, Momentum sets the tone for the Festival in a celebration of the creative abilities of artists. The event takes place between 3 – 18 October.
View PDF Guide online (Click to view)
Latest news
We are excited to be having a stand at this year's show, 1-4th June. SAW will be promoting all the varying and exciting work we do across the county and celebrating the thriving creativity we have here in Somerset. Polly Dolby our Open Studios Co-ordinator will be managing the stand and there throughout promoting Somerset […]
Willow birds – get createive with willow. Wednesday 15th June 2016 9.30am – 12.30 £35 Pylle Village Hall, Nr. Shepton Mallet BA4 6SZ Book online www.wildgardens.co.uk or email for further details
Somerset-born artist Sue Gilmore is holding an exhibition 'In the Time of Absence' at the For Every Cloud Gallery in Langport from June 1st to 11th. The work, which features paintings, drawings and photography, is inspired by Sue's own willow structures and uses charcoal she has made herself from pieces of willow. There is a […]
SAW exhibit at The Royal Bath and West Show!
[Wednesday, May 25, 2016]
Willow workshop
[Tuesday, May 24, 2016]
Exhibition- Sue Gilmore- 'in the time of absence'.
[Tuesday, May 24, 2016]


text:
Snowdrops are blooming.
By peter
2/22/12 - 7:08 pm
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Does walmart have a coin star machine in it
kgb answers » Business & Money » Company Details » Does walmart have a coin star machine in it
Wednesday, February 01 2012
Source: http://www.businessweek.com/investor/content/feb2008/pi2008028_098937.htm
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Visitor Information
Welcome to our guide for the area around St Dunstans Road in Hounslow. Below we present a selection of upcoming events, local attractions and great places to eat and shop.
The nearest station to St Dunstans Road is Hounslow West Tube Station which is about 15 minutes to the East.
Underground Stations
Further articles featuring St Dunstans Road on LondonTown.com
Plan the perfect year in the capital with our pick of the best events in London 2016. From January through to December, every month boasts an impressive line-up of entertainment. So, take a look at our guide and be sure not to miss a thing.
Hotels near St Dunstans Road
Booking multiple rooms?
Visit our group bookings page or call 020 7437 4370 for assistance
Room 1
London > Hotels > Mid-Range Chain Hotel from £39 34% off
Eastern Perimeter Rd, TW6 | 10 minutes from St Dunstans Road
The Hilton Garden Inn London Heathrow Airport is ideal for travellers flying in and out of any of the Heathrow terminals. Nearby to the Hoppa Bus ... More
London > Hotels > Budget Chain Hotel from £37 27% off
745 Bath Road, TW5 | 11 minutes from St Dunstans Road
Just a few miles along the A4 from Heathrow Airport, DoubleTree by Hilton London Heathrow Airport is a clean, modern hotel. With 200 air-conditioned guestrooms over ... More
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North Hyde Lane, TW5 | 25 minutes from St Dunstans Road
With its contemporary design and features such as an indoor pool, spa and gym, the Heston Hyde Hotel is a great alternative to the standard airport ... More
Pubs near St Dunstans Road
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Riverside, Twickenham, TW1 | 4 miles from St Dunstans Road
With probably one of the most idyllic settings of any of London's pubs, the White Swan is well worth a visit if you're in this neck ... More
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2 The Avenue, Ealing, W13 | 4.6 miles from St Dunstans Road
Escape the cabin fever of central London with a trip westwards to Ealing's impressive Drayton Court pub (just ten minutes on the train from Paddington Station). ... More
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Picture yourself spending some time with congenial friends, sharing your lives and pictures from your cell phones." They're curious about that cool game, song, movie, camping trip, art show, or other event that fascinated you. You talk about all kinds of stuff, poetry, styles, personal achievements, relationships, and bad days. You can share your inner child, and laugh together. They sympathetically listen to your feelings about serious topics like politics or climate change, even when they don't agree.
Personal validation comes from paying attention to one another, giving more than you get. Everyone respects you and themselves, despite our amazing range of personal tastes and interests. They'll tell you they don't agree with an idea or behavior without implying you're a bad person or somehow deficient. It's an "I'm OK, You're OK" kind of fellowship, where nobody tries to make himself look better by picking on somebody else.
Nobody here is into mind games. A discussion started with a loaded guilt-throwing question will be deleted.
This group is not intended to compete with other groups on topics they cover but to "fill in the cracks." Whenever a discussion dwells at length on a topic for which there's an existing group, we urge you to provide members a link to that group to continue along their tangent.
A comment is a shout-out, which will get lost in a few days, because the comment wall is just a random stack.
Please start a discussion to share stories, photos, and videos. Replies will pop up in your "latest activity" and a conversation can develop from the feelings and thoughts you contributed. Groups are built on discussions.
Started by Joan Denoo 20 hours ago. 0 Replies 0 Likes
Did the American Revolution produce significant benefits for native Americans, blacks, propertyless white males, and indentured servants?On blacks:"We think they are not, and that they are not included, and were not intended to be included…. They…Continue
Tags: white, propertyless, male, indentured, survants
Started by Ruth Anthony-Gardner. Last reply by Chris G on Friday. 16 Replies 0 Likes
Running of the bulls photobomb.Continue
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Many men join in the effort to reduce violence against women and children and other men. He speaks of the need to place responsibility on men instead of focusing on women to stop violence. He offers a breath of fresh air, as do so many of the men on…Continue
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Surreal, not just found in art.Continue
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New Displacements Associated with Conflicts & Disasters in 2015…Continue
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Hello Friends,I was ruminating a bit today on my sixty-some years existence. My mind went back to teenage years when I first figured out religion is not only obnoxiously loud, but also nothing I wanted anything to do with. Truly. I knew by age 15…Continue
yes Melinda Chris is right - you do look like sisters. I would have never guessed your age. You are both so beautiful and look so happy. I hope you have a wonderful birthday celebration.
You look like sisters! Congrats and have a happy day!
I wonder if the gorillas had been around people much. They seemed really tame and at ease. The guy with the camera must have been frozen in time which was probably the best thing to do when they were all around him.
Yes, Melinda, it's too bad we can't meet at 30,000 feet. That would have been fun. Remember: Always put your own mask on first, then help children or others near you. :)
Ian, I am sorry you didn't have Carol Burnett in Denmark! Her slapstick humor just outrageously funny. Everything she did was gross exaggeration of real life; kind of like Charlie Chaplin.
I love the jigging cat, Steph. Oh to have such energy!
We had three days of snow last week, but up to 50s this week and not below freezing. Hoe your temps modify too, Melinda. Your puppy feeding bowl looks sweet.
That handsome squirrel in snow compels me to want to let him in ... big mistake ... my neighbor had a squirrel in her home and it was a disaster, perhaps caused by the dog and cat trying to catch it. You sent a great photo Carl.
Your cat with fish cocktail and without have great expressions.
Patricia, I didn't realize Carol Burnett's show was 11 years! Her humor is priceless and timeless.
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About اكثرالسكسي تحميل مجاني
اكثرالسكسي تحميل مجاني Vegeta, both the prince, his king father and the Saiyan home planet originally named Planet Plant, means Vegetable; Raditz is not `radish`, and Kakkorotto is not `carrot`.
تحميل فيلم سكس Although not encouraged to do not so, main character Claude may not utilize the services of prostitutes, and then subsequently murder and rob them. The naruto vs Orichimaru `Episodes` was a joke.
اكثرالسكسي تحميل مجاني This is also worth watch show it has humor, team work two things that kids need to learn. The director must have not a vision of the given materials. اكثرالسكسي تحميل مجاني This game was also set in 1986 in Vice City, which was also based on Miami. The movie only gives you the who and the what but no why.
تحميل سكس To me this whole thing isn`t making any sense at all because there are not established fans across the globe, and Dragonball comic and cartoon itself has last more than TWO decades.
تحميل سكس سهير رمزي What is not wrong with this picture man?
تحميل فيلم سكس Like having Ang Lee directing the Hulk. تحميل سكس I`ve seen a live action version of Dragonball shot by the Malaysian years ago. At the end of the movie all i could do was ask `Why did they make this movie and who did they make this movie for?


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Tags » Monty Python And The Holy Grail
Movie Reviews #1
These are my thoughts and opinions on the movies that I watched over the weekend.
The Lego Movie
Emmett is an ordinary construction worker, so ordinary and unremarkable that no one can pick him out of a crowd. 1,241 more words
A Bible-Wielding Woman Marches Through Target To Protest Transgender Bathroom Rights
Transgender rights are the next big, national issue that America is going to have to deal with and sadly enough, that whole struggle will be marked by… 266 more words
Guinevere's Feisty Tale Continues in Nicole Evelina's Second Novel Camelot's Queen
Camelot's Queen is Nicole Evelina's new novel and the second in the Guinevere's Tale Trilogy. Evelina's first novel, Daughter of Destiny, introduced readers to a new version of Guinevere, focusing on a part of the story often ignored—her childhood and youth in the years prior to her meeting and marrying King Arthur. 692 more words
Monty Python and the Holy Fart
Bear with me, because it's going to take a while for me to get to the point. I'll tell you the conclusion up front: I'm learning how not to be such a snob about movies. 1,059 more words
A Look Back: Monty Python and the Holy Grail
When I was in junior high, we read T.H. White's "The Once and Future King," about the legend of King Arthur and the Knights of the Round Table. 780 more words


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What is 'Quantity Demanded'
A term used in economics to describe the total amount of goods or services that are demanded at any given point in time. The quantity demanded depends on the price of a good or service in the marketplace, regardless of whether that market is in equilibrium. The quantity demanded is determined at any given point along a demand curve in a price vs. quantity plane.
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BREAKING DOWN 'Quantity Demanded'
When a given quantity of a good or service is demanded, as determined by its price, it will then impact the amount of goods or services that will be purchased. The degree to which the quantity demanded changes with respect to price is called elasticity of demand.
Demand ScheduleIn economics, the demand schedule is a table of the quantity ...
Equilibrium QuantityThe quantity of an item that will be demanded at the point of ...
Income Elasticity Of DemandA measure of the relationship between a change in the quantity ...
Demand CurveThe demand curve is a graphical representation of the relationship ...
Cross Elasticity Of DemandAn economic concept that measures the responsiveness in the quantity ...
InelasticAn economic term used to describe the situation in which the ...
Related Articles
Law of DemandThe law of demand is one of the most fundamental principles in microeconomics. It's all about how price affects demand. According to the law of demand, for all other things remaining constant, ...
What Is Equilibrium?Equilibrium is a state of balanced supply and demand.
Personal Finance
Why We Splurge When Times Are GoodThe concept of elasticity of demand is part of every purchase you make. Find out how it works.
Calculating Income Elasticity of DemandIncome elasticity of demand is a measure of how consumer demand changes when income changes.
What's Aggregate Demand?Aggregate demand is a macroeconomic term describing the total demand in an economy for all goods and services at any given price level in a given time period.
What Is Supply?Supply is the amount of goods a producer is willing to produce at a given price, and is one of the most basic concepts in economics.
What is Demand?Demand is the economic term for the cumulative wants and desires of consumers as they relate to a particular good or service. Generally speaking, if all other factors remain constant, as demand ...
Macroeconomics: Supply, Demand and ElasticityBy Stephen Simpson DemandDemand is driven by utility – the pleasure or satisfaction that a consumer obtains from consuming a good or service. Total utility is a function of the quantities ...
Fundamental Analysis
How Demand Changes With a Variation in PriceWhat is demand elasticity?
What is Deadweight Loss?Deadweight loss can be applied to any deficiency caused by an inefficient allocation of resources.
Why is there a negative correlation between quantity demanded and price?Learn what the law of demand is, the basic assumption of the law of demand and why there is a negative correlation between ... Read Answer >>
What are some examples of demand elasticity other than price elasticity of demand?Learn about income elasticity of demand and cross elasticity of demand and how to interpret these two measures of demand ... Read Answer >>
Which factors are more important in determining the demand elasticity of a good or ...Learn about demand elasticity of goods and services and the main factors that influence the elasticity of demand. Read Answer >>
How does the law of supply and demand affect prices?Learn what the law of supply and demand is, what relationship it has with prices, and how the law of supply and demand affects ... Read Answer >>
What are some examples of the law of demand in real markets?Find out how the price of a good or service affects the quantity demanded, and explore instances of consumption reflecting ... Read Answer >>
How can Economic Order Quantity be used to lower inventory costs?Learn what economic order quantity is, how it is calculated and how to find the optimal economic order quantity to minimize ... Read Answer >>


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ABCs Of Learning How To Cook Dinner
There are few skills more important than knowing how to cook. Eating meals in your own home allows you to save money and make more nutritious dishes. When you are baking pastry crusts, try increasing the cooking time a bit. The color should be a darker caramel instead of the pale blond so many people … [Read more…]


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It's all silver and gray as Amtrak heads west over Rockville Bridge on a December day.
An empty Detroit Edison coal train heads for the Bailey Mine on the Manor Branch of the Monongahela Railway.
Chicago & Eastern Illinois F3(A) (F5A) 1405 with GP9 234 and FP7A 1608 at Danville, Illinois June 1967.
UP 1672 (SD40N) holds a spot in the 36th Street Yard, waiting for the call to sort freight cars.
When the Lehigh Valley was dissolved in 1976, its fleet of Alco C420's was conveyed to the Delaware & Hudson, where it remained intact for over a decade. On the D&H, the fleet's paint remained as ... (more)
Water Tower on station Momchilgrad opened on 12.04.1932 year were repaired this month. After 84 years again shone. Steam locomotive 46.03 was build in 1931 in Poland – H.CEGIELSKI Poznan. Type 1-6... (more)
As another day of first responder training awaits, the NS safety train basks in the sweet morning light at Bayview Yard in Baltimore. Photo taken with permission from Norfolk Southern.
With the ROSCO division, Renfe is renting overage locomotives to the private companies operating in Spain. With a curious paint scheme reminiscent of the colors of the Navy, the Vossloh 333.323 ha... (more)
In 1997 Switzerland celebrated "150 years of Railways in Switzerland". Many festivities took place all over the country and all the historic locomotives could be seen everywhere - long b... (more)
BB 262 is crossing the bridge in the Wutach Canyon with the morning train Weizen - Blumberg on the Sauschwänzlebahn.
Shot of the QGRY Henri-IV Yard.


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The last place you'd expect to find chickens roaming freely is outside a sandwich shop that serves chicken sandwiches.
According to the Greenfield police report:
That was the case Sept. 10, when a caller reported three chickens were running through the parking lot at Subway on 60th Street and Layton Avenue at about 4:30 a.m.
Police found four chickens there, apparent escapees from a yard in the 4700 block of South 60th Street.
The owner was contacted but wasn't too interested in re-cooping his chickens at that hour. But police were able to corral the chickens with the assistance of Milwaukee Area Domestic Animal Control Commission.
Police advised the city health department about the code violation, and the owner was given a copy of the city ordinance prohibiting chickens.
More from News and Features
- Man steals vehicle from business, returns to apply for job
- Light poles, electric wires down after traffic accident in Greenfield
- Dan Jansen Family Festival to bring old favs, new fun to Greenfield
- Greenfield man facing possible charges after threatening women with loaded gun
- High speed pursuit in Greenfield ends in crash in Milwaukee
- Greenfield Police Blotter: May 25, 2016
- Video: Summer fun in suburban Milwaukee
- Greenfield church to host prom for special needs students; Oconomowoc bank make large donation
- Sign-maker wants Highway 100 on-ramp reopened
- Greenfield Police Blotter: May 19, 2016


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If for some reason you aren't already appalled by the specter of a con artist occupying the Oval Office, a man who would lie about what he had for breakfast, look to those with whom Donald Trump has chosen to surround himself.
Just two weeks before California voters cast their ballots, a new poll shows Hillary Clinton's once-formidable lead against rival Bernie Sanders is now a statistical tie.
Rebecca Burns, In These Times assistant editor, holds an M.A. from the University of Notre Dame's Kroc Institute for International Peace Studies, where her research focused on global land and housing rights. A former editorial intern at the magazine, Burns also works as a research assistant for a project examining violence against humanitarian aid workers.


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|Nelly Thompson was a happy housewife who did not care much about anything but keeping her house and raising the kids. But there was one thought which deprived her of her sleep. She had once seen Terry, her son, in the shower, and his sizeable cock was her obsession. One evening she could not keep in her lust anymore and simply pulled Terry's pants off! At first she was anxious whether Terry would like her mature body, but the boy was so passionate:
Mary's father, lives with Mary, while their mother moved to another town after
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|Anthony Kowalski, a divorced teacher, loved his cute blonde daughter Amanda more than anyone in the world. Since her very childhood he enjoyed taking photos and filming her on camera. When she grew into a very beautiful teen girl, Anthony's shootings acquired a different taste. Sometimes he thought that it would have been great to film her naked, and one day he talked her into some naked posing, which led them to a totally hardcore incest scene:
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