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Just Delivered: Logitech G900 Chaos Spectrum Wireless Ambidextrous Mouse
Subject: General Tech | March 24, 2016 - 07:00 AM | Ryan Shrout
Tagged: wireless, mouse, logitech g, logitech, g900, chaos spectrum
While attending GDC last week and catching up on the world of VR that will be in our laps this spring and summer, I spent some time with Logitech to learn about the company's latest in gaming hardware. We already told you about the G610 keyboards using Cherry keyswitches but today Logitech is revealing a brand new wireless gaming mouse.
First, I know that a lot of gamers, both those in the professional spaces and those that strive to that level of competition, are going to have concerns about this being a wireless mouse. Logitech believes and has convincing evidence that they have built the best and fastest wireless implementation of any option on the market today. I'll go over some of their testing below, but first let's dive into the mouse itself.
Much to the delight of left handed users and anyone looking for a ambidextrous mouse, the G900 Chaos Spectrum is built for you! The design is balanced on both sides and even has a unique button configuration to permit thumb use for both lefties and righties. I have been mousing with it for the last three days, and as a right handed user, am completely comfortable with the design. As the name implies, the G logo on the mouse is completely controllable with RGB LEDs through the Logitech Gaming Software suite.
On the bottom of the G900 you'll find the on/off switch and sync button. Logitech tells us that you will be able to get at least 24 hours of continuous use out of a single charge of the mouse, 32 hours if you turn off lighting, and charge time is going to be around 2 hours. That's actually very good battery life for a high performance sensor like the PMW3366!
On the front is a micro USB port used for charging, which I'll touch on in a minute. The buttons on the G900 are unique as well, using a new mechanical pivot button design. Logitech claims they were built for "crisp, clean clicks". With the pivot point moved back towards the center of the mouse, engineers were able to reduce the travel distances between the buttons and switches and keep the amount of force required for the click to a minimum.
Continue reading our first look at the Logitech G900 Chaos Spectrum!!
My new desk mate
Earlier this month at the 2016 edition of the Consumer Electronics Show, Logitech released a new product for the gaming market that might have gone unnoticed by some. The G502 Proteus Spectrum is a new gaming mouse that takes an amazing product and makes it just a little better with the help of some RGB goodness. The G502 Proteus Core has been around for a while now and has quickly become one of the best selling gaming mice on Amazon, a testament to its quality and popularity. (It has been as high as #1 overall in recent days.)
We have been using the G502 Proteus Core in our gaming test beds at the office for some months and during that time I often lamented about how I wanted to upgrade the mouse on my own desk to one. While I waited for myself stop being lazy and not just switching one for the G402 currently in use at my workstation, Logitech released the new G502 Proteus Spectrum and handed me a sample at CES to bring home. Perfect!
|Logitech G502 Proteus Spectrum Specifications
|Max Acceleration
|Max Speed
|USB Data
|16 bits/axis
|USB Report Rate
|1000 Hz (1 ms)
|32-bit ARM
|Button rating
|20 million clicks
|Feet rating
|250 kilometers
|$79 - Amazon.com
The G502 Proteus Spectrum is very similar to the Core model, with the only difference being the addition of an RGB light under the G logo and DPI resolution indicators. This allows you to use the Logitech Gaming Software to customize its color, its pattern (breathing, still or rotating) as well as pair it up and sync with the RGB lights of other Logitech accessories you might have. If you happen to own a Logitech G910 or G410 keyboard, or one of the new headsets (G633/933) then you'll quickly find yourself in color-coordinated heaven.
In the box you'll find the mouse, attached to a lengthy cable that works great even with my standing desk, and a set of five weights that you can install on the bottom if you like a heavier feel to your mousing action. I installed as many as I could under the magnetic door on the underside of the mouse and definitely prefer it. The benefit of the weights (as opposed to just a heavier mouse out of the box) is that users can customize it as they see fit.
Continue reading our short review of the Logitech G502 Proteus Spectrum mouse!!
Logitech MX Master Mouse Announced
Subject: General Tech | March 27, 2015 - 11:03 AM | Scott Michaud
Tagged: mx master, mx, mouse, logitech
In the universe of computer mice, Logitech is one of the best known manufacturers. This one, the Logitech MX Master Wireless Mouse, is not part of their "G Series". At a price of $99.99 USD, or $119.99 CAD, it is their most expensive offering in that class.
The MX Master is a five button, right handed mouse. While that is not particularly exciting, one interesting feature is the horizontal scrolling tumbler on the thumb rest. The wheel on top scrolls up and down, while the one on the side can scroll left and right (or be reconfigured with Logitech's software). It is also a laser mouse that is capable of tracking on many types of surfaces, including thicker sheets of glass. It can be paired to three separate devices at once, either by Bluetooth or Logitech's proprietary receiver. Its rechargeable battery lasts about 40 days of 6 hour per day usage. Four minutes of charging yields about six hours of usage, and you can apparently even use the mouse while tethered.
The Logitech MX Master will be available in April for $99.99 USD.
Logitech Launches G303 Daedalus Apex Gaming Mouse
Subject: General Tech | March 5, 2015 - 09:00 AM | Ryan Shrout
Tagged: pmw3366, mouse, logitech g, logitech, g303
Here at the tail end of the Game Developers Conference in San Francisco, gaming accessory powerhouse Logitech is launching a new mouse in the family of G-series products, the G303 Daedalus Apex. That's a hell of a name for a mouse to be sure, but the feature set and technology included in this $60 gadget will get some attention from PC gamers and enthusiasts.
Based on the same basic housing and design as the Logitech G302, the G303 is an incredibly lightweight mouse targeted at the gaming community that has such a metric in mind. It includes the same button and spring combinations as the G302, a metal-spring tensioning system, as well as RGB lighting that can be customized with 16.8 million colors.
The most important new feature of the G303 though is its upgraded optical sensor. Using the Logitech PMW3366, the same sensor found in the Logitech G502, the G303 brings the same level of accuracy and performance to a lighter weight mouse. The technical feature set of the sensor are impressive:
|Logitech PMW3366 Sensor
|Sensor Features
|Exclusive Clock Tuning Technology
Delta Zero™ Technology
Zero Smoothing
Zero Filtering
No Pixel Rounding
No Pixel Doubling
Sensor Surface Tuning
|Resolution: 200 – 12,000 dpi
Max. acceleration: >40G
Max. speed: >300 ips
|USB data format: 16 bits/axis
USB report rate: 1000 Hz (1ms)
Microprocessor: 32-bit ARM
Obviously a 12,000 DPI rate is a bit much for any user to really utilize but the capability of the PMW3366 allows it as an option. Other features directly target the gaming market, like Zero Smoothing that guarantees no lag or latency in mousing due to comparisons of sensor data. Clock Tuning is based on Logitech's inclusion of a crystal that maintains speed and acceleration characteristics despite traditional degradation of these traits over time or due to part-to-part variance. Each G303 should feel the same and the performance should be identical from day one through year one.
The G303, along with the G502, that utilizes the PMW3366 sensor, can take advantage of Surface Tuning – the ability for the mouse to tune itself to the texture of the plane it's being used on. By enabling the feature in Logitech's software then moving the mouse in a series of figure eights, surface-to-surface experiences should be similar.
G303 Daedalus Apex also has advanced Surface Tuning technology as an integral feature of the PMW3366 sensor. Surface Tuning is a technology used to tune mouse parameters to match a surface. Most gaming mice that have "surface tuning" optimize only for lift-off distance by adjusting LED intensity, which can sacrifice maximum speed. G303 Daedalus Apex optimizes the sensor dynamic range to match the properties of your mouse surface for maximum high-speed performance in addition to lower lift-off distance.
The same build quality and software infrastructure that sit behind the G302 and the rest of the Logitech G gaming mice follow to the G303 Daedalus Apex. Buttons rated at 20 million clicks, metal spring tensioning system, intuitive software to manage the DPI presets and 6 programmable buttons along with easy customization of the RGB lighting system create a total package that is beyond the $59 MSRP. As a direct comparison, the G302 will continue to sell for $49 using the older sensor controller while the G502 runs at $69 leaving plenty (maybe too many) options for gamers.
Logitech sent me at G303 and G502 for testing late last week and I am planning a short story on my experiences. It will be hard to beat the G402 for sheer speed (remember our video review trying to break the accelerometer) but a direct comparison is forthcoming.
No one has talked about mouse mats in a while
Subject: General Tech | February 13, 2015 - 10:09 PM | Jeremy Hellstrom
Tagged: mouse, gaming mat, input, XTracPads, Carbonic, Ripper, Ripport XXL
They are not the most glamorous of peripherals but they do save your desk and can help you with your accuracy, so pop over to Overclockers Club to take a look at XTracPads. They offer three different sized gaming mats from the paper sized Carbonic at 8.5" x 11" x 1/8" to the Ripper at a larger 11" x 17" x 1/8" to the immense Ripper XXL at 36" x 18" x 1/8" which is going to cover a goodly piece of your desk. They are priced at roughly $15, $22 and $35 so it is not a major investment to pick up and well worth it if you are looking to replace an old mat which has seen better days.
"From a casual gamer perspective, I am sure someone who can game competitively will likely notice a greater improvement than I. Personally, I have had trouble with mouse pads that were too hard, not stiff, but solid cutouts of plastic (I don't even know if they are made anymore really). I have also had issues with mouse pads that accumulate a bunch of gross after a bit of use. I can live with poor or cheap mouse pads, but now that I have had a taste of the other side I really don't want to anymore."
Here is some more Tech News from around the web:
- Thermaltake Tt eSPORTS Talon Gaming Mouse Review @ OCC
- Cougar 600M Gaming Mouse Review @HiTech Legion
- Cougar 600K @ HardwareHeaven
- ROCCAT Ryos TKL Pro Mechanical Keyboard Review @ Techgage
- Corsair Gaming K70 RGB Mechanical Keyboard @ techPowerUp
Can you really have a wireless gaming mouse?
Subject: General Tech | August 18, 2014 - 09:05 PM | Jeremy Hellstrom
Tagged: input, mouse, wireless gaming mouse, SteelSeries Sensei
Gaming mice have wires as it reduces input lag that would otherwise be the death of you while gaming. Unfortunately for some this means they cannot sit on the couch streaming YouTube to their TVs since the wire on their mouse just isn't long enough. SteelSeries claims to have overcome the technical problems of gaming wirelessly with their SteelSeries Sensei. The software is definitely aimed at gamers, with an impressive array of settings to tweak and an impressive macro editor but that is not enough to solve the performance issues. Believe it or not when TechGage compared it to a wired mouse they could not detect any difference whatsoever. I would still recommend wearing pants while frying bacon regardless of your final mouse choice.
"Want a high-performance wireless gaming mouse that doesn't have its battery-life measured in seconds? Well, SteelSeries has released its renowned Sensei into the wild, free to run and frolic in grassy meadows, without the need of being tethered to unsightly cables. Does the result live up to our high expectations? There's only one way to find out."
Here is some more Tech News from around the web:
- EVGA TORQ X10 Gaming Mouse – A Big Contender In a Big Market @ Techgage
- Aorus Thunder M7 MMO Gaming Mouse and Thunder P3 Gaming Mouse Pad Review @HiTech Legion
- Logitech G402 Hyperion Fury @ HardwareHeaven
- XTracGear Ripper Mouse Pad @ Benchmark Reviews
- Tt eSPORTS POSEIDON Z Illuminated Mechanical Gaming Keyboard Review @ Legit Reviews
- Roccat ISKU FX Gaming Keyboard @ Benchmark Reviews
- CM Storm QuickFire Rapid-i Mechanical Gaming Keyboard Review @ Legit Reviews
Optical + Accelerometer
When I met with Logitech while setting up for our Hardware Workshop at Quakecon this year, they wanted to show me a new mouse they were coming out with. Of course I was interested, but to be honest, mice have seemingly gone to a point where I could very rarely tell them apart in terms of performance. Logitech promised me this would be different. The catch? The G402 Hyperion Fury includes not just an optical sensor but an accelerometer and gyro combo.
Pretty much all mice today use optical sensors to generate data. The sensors are, basically, taking hundreds or thousands of photos of the surface of your desk or mouse and compare them to each other to measure how far and how fast you have moved your mouse. Your PC then takes that data from the mouse at a USB polling rate, up to 1000 Hz with this mouse, and translates it into mouse movement on your desktop and in games.
There is an issue though - at very high speeds of mouse movement, the optical sensor can fail. It essentially loses track of where it is on the surface and can no longer provide accurate data back to the system. At this point, depending on the design of the mouse and driver, the mouse may just stop sending data all together or just attempt to "guess" for a short period of time. Clearly that's not ideal and means that gamers (or any user for that matter) is getting inaccurate measurements. Boo.
To be quite honest though, that doesn't happen with modern mice at your standard speeds, or even standard "fast" gaming motions. According to Logitech, the optical sensor will start to lose tracking somewhere in the 150-180 IPS, or inches per second. That's quite a lot. More precisely that is 3.8 meters per second or 8.5 miles per hour.
Continue reading our overview of the Logitech G402 Hyperion Fury Gaming Mouse!!
Introduction, Hardware, and Subjective Feel
This review comes before the end of the pre-order period. The reason why I targeted that deadline is because the pre-order perks are quite significant. First, either version of the mouse is listed for about $50 off of its MSRP (which is half price for the plastic version). EVGA also throws in a mouse pad for registering your purchase. The plastic mouse is $49.99 during its pre-order period ($99.99 MSRP) and its carbon fiber alternative is $79.99 ($129.99 MSRP). EVGA has supplied us with the plastic version for review.
Being left-handed really puts a damper on my choice of gaming mice. If the peripheral is designed to contain thumb buttons, it needs to either be symmetric (because a right hand's thumb buttons would be controlled by my pinky or ring finger) or be an ergonomic, curved mouse which comes in a special version for lefties that is mirrored horizontally (which is an obvious risk, especially when the market of left-handed gamers is further split by those who learned to force themselves to use right-handed mice).
Just Delivered: EVGA Torq X10 Gaming Mouse
Subject: General Tech, Cases and Cooling | May 27, 2014 - 04:19 AM | Scott Michaud
Tagged: mouse, laser mouse, gaming mouse, evga
It has been a while since I reviewed hardware and, when I did, they were all keyboards. Being a southpaw, it is fairly difficult to review higher-end mice. When offered to review the EVGA Torq X10 Gaming Mouse, I noticed that it is a (nearly) symmetric design with nine (9) buttons: five (5) on the top, two (2) on the left for right-handed thumbs, and two (2) more, identical buttons on the right for left-handed thumbs.
Of course, the off-hand buttons can still be used for time-insensitive commands, like pinging the map of a strategy game. Personally, I tend to rebind mouse sensitivity to the pinky-buttons and rebind what is usually meant for DPI adjustments to pinging maps or, on games like Battlefield: Bad Company 2, fly up and down (for the UAV).
A quick unboxing shows the underside of the mouse, an accessory pouch made out of paper with a getting started guide and what looks to be sticker-based grips, a plastic bag of weights, and that metal thing beside the mouse is a torx screwdriver. This screwdriver is what will be used to customize the palm angle by turning its adjustment at the rear of the mouse.
While I have not yet plugged it in, I did play around with its grip adjustment. You probably will not notice its effects unless you are looking for it, but it does result in significant changes to the touch. I will discuss this, and its other features, more in my upcoming full review.
As for pricing, EVGA is currently accepting pre-orders through Newegg. The base version is available for $49.99 (pre-order price, $99.99 MSRP) with a "carbon fiber" version, an identical mouse outside of the surface material, also on pre-order for $69.99 (pre-order price, $129.99 MSRP). It is unclear whether they will ever make it up to their MSRP but, if they do, an almost half-price pre-order (with a free mouse pad if you pre-order, register your mouse, and upload your invoice, apparently) is pretty gigantic.
It is expected to ship in a month (late June). I hope to have at least a preliminary review, if not a full one, up with time left for pre-orders.
Faith in Humanity Declining: Camera Mice.
Subject: General Tech, Cases and Cooling | January 19, 2014 - 01:44 AM | Scott Michaud
Tagged: camera, mouse, camera mouse, Japan
Have you ever been sitting at your laptop or desktop thinking, "I really need a selfie right about now and this webcam simply will not do"? I have no idea what is wrong with you. Do you not have a cellphone if spontaneous self-photography means that much?
But at least a Japanese company has your back... or is it front?
For the love of... it's even being held the wrong way!!!
Introducing the Camera Mouse. It is a mouse with a camera in it. It is useful if you want to take pictures of things with your mouse. It will be sold by King Jim Co., LTD. which is one of the largest office supplies manufacturers in Japan.
While I have been thinking about this news story, I have been thinking about legitimate use cases. It has been a struggle. I just cannot understand why someone would want to purchase a 1600x1200 camera which is hard-wired to their computer. Thus far, I have only come up with a single possibilities (although it would require significant software development resources that I doubt they intend to provide). The only way I could see myself purchasing this mouse is if it came with OCR and translation software so that I could point it at my monitor and automatically translate any text on screen.
Even then, I expect the vast majority of foreign language content would be in a web browser and two of those automatically translate text anyway. It would help for text in images or text in videos but otherwise I could not see the point even then. Moreover, all of this assumes the software even exists in a reasonable package (Bluestacks running Google Translate is probably no more useful than a cell phone).
But who knows. I could be missing the bigger picture. I could be missing the subtle nuances of their target audience. Maybe I just need to see things at two megapixels from under a sweaty palm.
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Do-it-yourself (DIY), perhaps even more than rugby, is New Zealand's passion. PlaceMakers is a temple to our love affair with making and fixing things by ourselves. While this "man alone" approach might be ok if you're tiling a bathroom it leads to major problems in business.
OPINION: Building a successful company requires multiple skill sets: sales, finance, marketing, legal, research & development, intellectual property, strategy, HR etc. It is impossible for a single person to possess all these skills - no one is that good. The solution is obvious: build a team that (collectively) has a broad range of skill sets.
Unfortunately however we Kiwis think of "team" very narrowly, generally as "the people who work for me". This means that anything the company needs to do is done by the people in the company. We do it ourselves - as I said: we love DIY.
Compare this to Silicon Valley which has a very different notion of "team". Team is not just "staff" but includes key advisors to the company: your lawyer, your strategy adviser, your subject matter expert, are all part of "the team". This makes sense: when you're getting started you don't need high powered HR skills everyday so it is sensible to have a strong HR person on retainer who is there when you need them.
Successful CEOs focus staff on what the company is really good at (its core business) and don't hesitate to engage external experts and providers to do all the other stuff. Both groups are part of the team. Some advisers are regarded so highly that smaller companies end up pitching just to use their services! One of the benefits a top level venture capitalist in Silicon Valley brings is their ability to get you onto the client list of the best lawyers, consultants and advisors.
These advisors are paid well, not just because they are highly skilled, but because the advice they give, as a member of your team and someone who understands your company, often shaves months off development timeframes, avoids critical errors, identifies new opportunities and creates new networks. In short good external advice makes a profound difference.
Unfortunately in New Zealand our DIY approach means we tend to:
1. only reluctantly engage external providers and experts
2. engage them only when we've tried to fix a problem and we are finally forced (note that word) to admit it's beaten us.
3. use the cheapest lawyer / accountant / expert / advisor we can find (preferably free).
This approach is driven not just by a desire to save money but also by a general reluctance to ask for advice. But DIY outside your core expertise is simply not a winning strategy:
1. The cost of fixing mistakes grows exponentially over time. Retaining an expert who stops you driving off the cliff is much cheaper than paying one to meet you with the ambulance at the bottom.
2. Irregular engagement with an advisor means they are constantly playing catch up - you'll spend a lot of time and money getting them back up to speed when they could be giving you regular, timely advice.
3. You get what you pay for. Poor advice can rapidly ruin even a promising business. Remember: the only thing more expensive than good advice is bad advice.
Trying to do a job your team is not qualified for wastes valuable resources and almost invariably produces a poor result. Much like trying to change the oil in your car when you don't know which end it goes in and which end it comes out. If you want something done right you need to employ a professional.
The take-home message here is: if you hire high quality, professional advisors and engage them regularly, as part of your team, they will come up with ideas you never thought of, help you avoid costly mistakes and spot opportunities you didn't see. You'll have access to a broad spectrum of expert advice from people who care about your business, which is after all, what you want from a great team.
Paul Adams is CEO of EverEdge IP, an intellectual property strategy, management and technology commercialisation firms. He has been named one of the world's top IP strategists and was the recipient of the Outstanding IP Leader Award 2012. www.EverEdgeIP.com.
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"Just come in and just be Nate."
Those were the words of advice Nate Robinson remembers hearing from Doc Rivers when he was traded to the Celtics last week.
So what exactly does "just being Nate" mean?
"Just be me," he explained on Tuesday night. "Play with fire and energy. I play with a lot of energy and play for the love of the game, and I guess that's what it is."
But there are many layers to someone with such a big personality. Those who played with him on the Knicks have seen first-hand what it means for the guard to just be himself. Here's what three of his former teammates think Celtics fans should know about Robinson.
Dangerous When Hot
After sitting out 14 straight games this season, Robinson scored 41 points in 38 minutes off the bench to carry the Knicks to victory over the Hawks on Jan. 1. Being sidelined for a month did not stop him from jumping into action when called upon. Al Harrington remembers Robinson's performance clearly.
"There was this one time this year, New Year's Day, we watched him score [nearly 20] straight points," Harrington recalled. "So there's a lot of times like that, hustle plays that he makes, doing stuff that nobody in the league could do except for a guy like him. So he's always out there making plays."
There When You Need Him
The Knicks dropped 14 of their first 17 games to start the season and were on another losing streak before Robinson was traded. In spite of the team's consistent struggles, Robinson tried to keep spirits up. Wilson Chandler attests to the impact of Robinson's vocal support.
"It's a long season and we were on a five-game losing streak," Chandler recounted. "He'd just come in the locker room and say, 'It's a long season and we've got a lot of games left. Don't get too down. We've got this amount of games and we can get right back in this.' You look at it as it's the truth. Coming from your teammate is different than coming from outside, like from your family or friends. It's somebody that's in the same situation as you. … He's a good teammate as far as being there for you, sticking around, being there when you're down. He likes to joke around a lot and sometimes you need that in the locker room."
From Joking Around to Getting the Job Done
Robinson may enjoy joking around the off the court, but the Celtics require focus on the court. (You don't see Kevin Garnett laughing on the parquet.) But even with Robinson's jovial personality, Chris Duhon says he can mesh with that intensity.
"It's going to be interesting, but I think Nate, he's very smart," Duhon said. "He's going to be able to adjust to different personalities and he's going to be able to feel his way. He's still going to be able to be himself, but he's probably going to pick and choose when he goes all out. But I think when it comes game time, depending on how the locker room is, he'll figure it out. If it's all business, he'll be all business. He's very smart in that aspect."
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We end the week with the best in sound Laroy Streat continues to set fire to the airways with his music.
The guys talk Red Sox pitching and the problems that could arise with Buchholz struggles.
Mut recaps the Sox 8-2 loss to the Rockies.
Mut recaps the Sox 10-3 win over the Rockies.
Carson Smith needs Tommy John and Jackie Bradley Jr. reaches 28 game hitting streak
Jerry is joined by Graig Murphy to talk stand up comedy. Until Graig pretty much hijacks the podcast to tell his side of the "Big Show Unfiltered" story.
Ben and Russ preview the Champions League Final between Atletico Madrid and Real Madrid. Who we want to win, who we think will win, and why. We also talk about our wishes for the USMNT.
The Dennis and Callahan malcontent is joined by former WEEI personality Pete Sheppard to talk about his past involvement with the station and his current gig in New Hampshire. You'll be glad to hear Pete hasn't changed one bit.
The Dennis and Callahan malcontent is joined by former WEEI personality Pete Sheppard to talk about his past involvement with the station and his current gig in New Hampshire. You'll be glad to hear Pete hasn't changed one bit.More from this show
Ted Olson, joins the guys to talk about how he and Tom Brady plan to attack the latest court ruling.More from this show
Lucy's parting shot after not taking the job is to attack Dino for how he treats producers.More from this show
The producer search is over now that Paul and Ken have accepted the job. With their new found job security, they are free to bitch about working three A-holes, the Lucy charade, and the process behind getting the gig.More from this show
The guys go to battle with a caller who claims to be a Worcester attorney that would like to defend the role judge Andrew Mandell had in letting Jorge Zambrano back on the streets shortly before he killed a police officer.More from this show


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Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion
Version of Record online: 6 FEB 2009
DOI: 10.1002/ijc.24349
Copyright © 2009 UICC
International Journal of Cancer
Volume 124, Issue 12, pages 2771–2779, 15 June 2009
Additional Information
How to Cite
Kabashima, A., Higuchi, H., Takaishi, H., Matsuzaki, Y., Suzuki, S., Izumiya, M., Iizuka, H., Sakai, G., Hozawa, S., Azuma, T. and Hibi, T. (2009), Side population of pancreatic cancer cells predominates in TGF-β-mediated epithelial to mesenchymal transition and invasion. Int. J. Cancer, 124: 2771–2779. doi: 10.1002/ijc.24349
Publication History
- Issue online: 13 APR 2009
- Version of Record online: 6 FEB 2009
- Accepted manuscript online: 6 FEB 2009 12:00AM EST
- Manuscript Accepted: 28 JAN 2009
- Manuscript Received: 8 AUG 2008
Funded by
- Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Scientific and Culture of Japan
- Abstract
- Article
- References
- Cited By
- TGF-beta;
- cancer stem cell;
- invasion;
- metastasis;
- E-cadherin
We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epithelial phenotypic marker, and the cells formed tightly contacted cell cluster, which is a representative epithelial phenotypic appearance. When the SP cells were incubated in the presence of TGF-β, SP cells changed their shape into mesenchymal-like appearance including spindle shaped assembly. This alteration was associated with significant reduction of E-cadherin expression level. TGF-β induced EMT-associated gene alteration such as reduction of E-cadherin mRNA and induction of Snail mRNA and matrixmetalloproteinase (MMP)-2 mRNA. Finally, SP cells exerted notable matrigel invasion activity in response to TGF-β treatment, whereas MP cells did not respond to TGF-β-mediated invasion. In conclusion, these results suggest that SP cells from pancreatic cancer cell line possess superior potentials of phenotypic switch, i.e., EMT/MET, micro-invasion, and in vivo metastasis, as compared to MP cells. Because micro-invasion and metastasis are key mechanisms of cancer malignant potential, SP cells would be the attractive target for preventing cancer progression. © 2008 UICC


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Fed up with the capital's crumbling roads, a group of Moscow activists has mounted a spray-paint attack on city potholes, hoping to gain action from local officials.
Members of the Angry Citizens, or Serdity Grazhdanin, movement took to the streets over the weekend, armed with cans of spray paint.
Members of the Angry Citizens movement in Moscow spray-painted over 100 potholes in the city and plan to send photos of them to the city's transportation agency.
Around 50 activists took part in an event called "Color Potholes" on Friday (March 29) night and Saturday (March 30) morning. The activists covered more than 100 potholes in Moscow's roads and spray painted them, said Anastasia Borisevich, a spokeswoman for the movement, The Moscow News reported.
"The action went very well," Borisevich told RIA Novosti. "The participants found more than 100 potholes. Everybody observed traffic regulations and wore vests."
Pothole Pictures Sent
Pictures with the potholes' locations will be sent to Dorogi Moskvy (Moscow Roads), the government portal created to facilitate improvements in the city's transportation system.
Dorogi Moskvy's staff are supposed to oversee roadwork and repairs by relevant organizations.
The transportation agency, Dorogi Moskvy, said it currently accepts complaints and questions from users of the Angry Citizens' website.
Since October 2012, Dorogi Moskvy's website has been accepting complaints and suggestions from its own registered users and users of the Angry Citizens' website, the government agency said. In December, it started accepting inquiries from another activist website, RosYama.
"This means that people who lodge complaints with the Serdity Grazhdanin and RosYama websites can be sure that their complaints will be forwarded to Moscow's geo-information websites and will shortly be addressed by authorities," the website said.
According to RIA Novosti, about 30,000 people die each year in Russia from traffic accidents that are usually attributed to poor road conditions and traffic violations.
Comment from Mike McCloud, (4/5/2013, 7:42 AM)
There is not enough spray paint in Boston...
Comment from Richard Hogue, (4/5/2013, 8:25 AM)
That wouldn't work in the US. The activists would be arrested for vandalism and felony destruction of public property. Then government officials would ban the sale of spray paint.
Comment from Mike McCloud, (4/8/2013, 7:46 PM)
We are turning into Russia and Russia is turning into US.
Join the Conversation:
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Struggling Utah Jazz suffer stinging loss to Los Angeles Clippers
Jeffrey D. Allred, Deseret News
SALT LAKE CITY — Wednesday's blowout loss shocked the Utah Jazz.
Friday night's setback simply stung.
Two nights after getting blown off their home court by the Golden State Warriors, the Jazz played immensely better but blew a 19-point, second-half lead in a heartbreaking 116-114 loss to the Los Angeles Clippers.
"Real tough one," Jazz point guard Jamaal Tinsley said. "We just didn't finish the game out."
Randy Foye seemed visibly shaken in his locker while trying to swallow the Jazz's second last-second loss in a month to his former team, which improved to an NBA-best 24-6 with its 16th straight victory.
Despite outplaying the Clippers for most of the night, the Jazz fell to 15-16 after losing their third consecutive home game and suffering their sixth setback in eight outings.
"A loss is a loss. If we played bad or we played well enough to win, we still lose," Jazz center Al Jefferson said. "At the end of the day, we lost the game."
Foye scored a season-high 28 points and had a chance to cap off a heroic night with the ball in his hands with time running out.
But as the Jazz shooting guard approached the 3-point line after an inbounds pass with 3.4 seconds remaining, the 6-4 Foye was approached by 6-7 Matt Barnes.
The Clipper forward leaned into Foye, who also made sure to create contact while heaving up the game-winning attempt.
The 3-pointer clanged off the rim at the buzzer, but no whistle was called — much to the loud dismay and protest of the Jazz and their sellout crowd of 19,911.
"He played good D, man," Foye said. "That's all I've got to say about that."
The guard, who'd hit 5-of-8 3-pointers before that final try, elaborated when asked about whether or not there was enough contact to warrant a foul and possible game-winning free throws.
"Yeah. I pumped fake. He knew I wanted to shoot the 3 and I felt the contact," Foye said. "I went straight up and it made me shoot the ball straight down. It just was a tough play."
That came seconds after another tough play.
With 3.4 seconds remaining, Jefferson reached in and fouled a driving Chris Paul as the speedy point guard came out of a pick-and-roll on the 3-point arc.
Paul hit both free throws — after splitting a pair 14 seconds earlier — and forced the Jazz to make something positive happen on their final possession.
"We were trying to trap and the referee called a foul," said Jefferson, whose two free throws with 17.1 seconds remaining tied the crazy game at 114-all.
"It don't matter what I think. He called it."
Big Al, who had 22 points and eight rebounds, eluded the question about whether or not he second-guessed himself on reaching in against Paul, who was 20-plus feet away from the basket with time running out.
"I reached. They called a foul," Jefferson said. "There ain't nothing we could do about it."
The Jazz found themselves trailing 29-22 after the first quarter, but a spunky effort by reserves Earl Watson, Alec Burks, Gordon Hayward, Derrick Favors and Enes Kanter helped Utah outscore the Clippers 36-19 in the second quarter.
That 10-point halftime lead was then stretched to 19 four minutes into the second half when Paul Millsap hit a pair of free throws.
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DEFINITION of 'Ma And Pa Shop'
A colloquial term for a small, independent, family-owned business. Unlike franchises and large corporations, which have multiple operations in various locations, ma and pa shops usually have a single location that often occupies a physically small space. The "shop" could be any type of business, from an auto repair shop to a bookstore to a restaurant.
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BREAKING DOWN 'Ma And Pa Shop'
Ma and pa shops may have difficulty competing with larger businesses. Because they cannot take advantage of the same economies of scale, their prices are often higher. Ma and pa shops are able to stay competitive when they differentiate themselves from their large-scale competitors by offering a unique product, exceptional service or a more personalized feel.
Mom And PopA colloquial term for a small, independent, family-owned business. ...
Purchase And Assumption - P&AA transaction in which a healthy bank or thrift purchases assets ...
FranchiseA type of license that a party (franchisee) acquires to allow ...
FranchiserA party in a franchising enterprise that ultimately owns the ...
Franchise FactorThe measurement of the impact on a company's price-earnings (P/E) ...
Power centerA large (250,000 to 750,000 square ft.) outdoor shopping mall ...
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A collection of things you think only you do. Go ahead and confess. You probably aren't the only one.
"Whats best about having sex with twenty six year olds?..... Theres twenty of them!."
via: Anti-Pickup Line
"tonight... we test drive... a fiat punto. a VW golf and adam burdass."
via: Clarksonisms
via: Pointless Inventions
"The ability to be able to transform into a spork.."
©2008-2014 Things You Think Only You Do. All rights reserved.
A Horse Head Huffer Production.
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Relevant offers
TV3 owner MediaWorks has bought radio station Mai FM for an undisclosed sum.
MediaWorks, which also owns a stable of radio stations including Radio Live, The Rock and The Edge, said today it was acquiring Mai FM's assets from Mai Media and Te Runanga o Ngati Whatua.
The deal includes the right to operate 88.6 Mai FM in Auckland and the purchase of assets such as the Auckland studio, two frequencies in Northland, plus two unused frequencies in the Orewa region.
"Our message is that nothing changes for Mai FM, except a greater level of investment and support for the brand," MediaWorks chief executive Brent Impey said.
Impey described the deal as the final piece of the jigsaw for MediaWorks' Auckland radio plans. The deal is set to settle on March 31.
MediaWorks itself is owned by Australian private equity fund Ironbridge Capital.
- Fairfax Media
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