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What does MNBP stand for?
MNBP stands for Manufacturer of Non-Beverage Product
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- MSX Non-Basic Input Output System
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- Malden Neighborhood Basketball League (Malden, MA)
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- Migratory Nongame Birds of Management Concern (California)
- Micronucleated Binucleated (cells)
- Madison Network of Black Professionals (Madison, WI)
- Malta National Biodiversity Platform (est. 2003; European Platform for Biodiversity Research Strategy)
- Manassas National Battlefield Park (Virginia)
- Money No Be Problem
- Manganese Bromide
- Multiprojection Narrow Beam Radiography (radiology)
- Methyl 4-Nitrobenzene Sulfonate (biomedicine)
- Micro-Nano-Bio Systems
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- Mobile Nylon Bag Technique


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If it sells, it's art.
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~quotes on Places by Oliver Wendell Holmes, The Poet at the Breakfast Table, 1872
You put a baby in a crib with an apple and a rabbit. If it eats the rabbit and plays with the apple, I'll buy you a new car.
~sayings on Vegetarianism by Harvey Diamond
There is still no cure for the common birthday
~quotations on Birthdays by John Glenn
The number of shots taken by an opponent who is out of sight is equal to the square root of the sum of the number of curses heard plus the number of swishes.
~inspirational wrestling quotes by Michael Green, The Art of Coarse Golf, 1975
The typical gambler might not really understand the probabilistic nuances of the wheel or the dice, but such things seem a bit more tractable than, say, trying to raise a child in this lunatic society of ours.
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Motivational Quotes
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I've had a perfectly wonderful evening. But this wasn't it.
~quote about Famous Saying by Groucho Marx
Salvador Dali seduced many ladies, particularly American ladies, but these seductions usually consisted of stripping them naked in his apartment, frying a couple of eggs, putting them on the woman's shoulders and, without a word, showing them the door.
~quotes on Funny Saying by Luis Bunuel
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~quotations on Golf by Bob Hope
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~inspirational wrestling quotes by Walt Whitman
I am a nutritional overachiever.
~saying about wrestling by Author Unknown
When I do good, I feel good. When I do bad, I feel bad. That's my religion.
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Do what we can, summer will have its flies.
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Car service: If it ain't broke, we'll break it.
~sayings on Humor by
A nickname is the hardest stone that the devil can throw at a man.
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Better to light a candle than to curse the darkness.
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You don't love a woman because she is beautiful, she is beautiful because you love her.
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In the lifetime of one person, we went from figuring out where we came from to figuring out how to get rid of ourselves.
~quote about Society by Jack Horner, on the eighty years between Darwin's On the Origin of Species and the nuclear bomb, in
When you are sorrowful look again in your heart, and you shall see that in truth you are weeping for that which has been your delight.
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I held a moment in my hand, brilliant as a star, fragile as a flower, a tiny sliver of one hour. I dripped it carelessly, Ah! I didn't know, I held opportunity.
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I am an invisible man.... I am a man of substance, of flesh and bone, fiber and liquids - and I might even be said to possess a mind. I am invisible, understand, simply because people refuse to see me.
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When we played, World Series checks meant something. Now all they do is screw up your taxes.
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Women, don't get a tattoo. That butterfly looks great on your breast when you're twenty or thirty, but when you get to seventy, it stretches into a condor.
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If our country is worth dying for in time of war let us resolve that it is truly worth living for in time of peace.
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I ask not for a lighter burden, but for broader shoulders
~sayings on Adversity by Jewish Proverb
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The fear of being laughed at makes cowards of us all.
~inspirational wrestling quotes by Mignon McLaughlin, The Neurotic's Notebook, 1960
Look at a stone cutter hammering away at his rock, perhaps a hundred times without as much as a crack showing in it. Yet at the hundred-and-first blow it will split in two, and I know it was not the last blow that did it, but all that had gone before.
~saying about wrestling by Jacob A. Riis
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~quotations on Sports by Vince Lombardi
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~saying about wrestling by Earl Gray Stevens
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Home > News > Regional
Friday, 14 March 2014 | MYT 5:09 PM
Pakistani security personnel arrive at the site of a bomb explosion in Quetta on Friday. -AFP
QUETTA, Pakistan: A bomb blast on Friday killed 10 people and wounded 31 others in Pakistan's restive southwestern city of Quetta, officials said.
City police chief Abdul Razzaq Cheema said a vehicle carrying security forces appeared to have been the target of the attack, which occurred outside a college in the centre of the city.
Quetta is the capital of the southwestern province of Baluchistan, which is rife with separatist and Islamist militants and plagued by sectarian bloodshed.
"Ten people were killed and 31 injured. Around eight are in critical condition," Cheema told AFP, adding that eight to 10 kilos of explosives were used in the bomb.
Doctor Rashid Jamal at the government-run civil hospital Quetta confirmed the number of dead and wounded.
The city has been hit by numerous attacks in recent years, including two devastating bombings early last year targeting minority Shiite Muslims that killed nearly 180 people.
Baluchistan, the size of Italy and rich in copper, gold and natural gas, is Pakistan's largest but least populous province.
It is also the least developed, which has exacerbated a long-running ethnic Baluch separatist movement that wants more autonomy and a greater share of its mineral wealth.
The latest armed insurgency rose up in 2004 and separatist groups still regularly attack Pakistani forces.
Rights groups accuse the military and intelligence agencies of kidnapping and killing suspected Baluch rebels before leaving their bodies by the roadside.
Friday's attack was the deadliest attack to hit the province since January 22, when a bomb targeting a bus carrying Shiite pilgrims returning from Iran killed 24 people.
The militant outfit Lashkar-e-Jhangvi (LeJ), regarded as the most extreme Sunni terror group in Pakistan and accused of killing hundreds of Shiites since its emergence in the 1990s, claimed responsibility for that attack. -AFP
Tags / Keywords:
Taliban militants
bomb attacks
Tehreek e Taliban Pakistan
Sarband village
Jakarta attackers possibly brought together by local IS-affiliated Bahrun
Indonesia detains militants planning bomb attacks
Pakistan kills 34 militants in air strikes
Bangladesh bans night buses after deadly bomb attacks
#Pakistan: A hashtag nation
Journalist shot dead in Philippine capital
Obama honours victims of A-bomb
No takers for free HK spa
US forces in Okinawa under curfew after suspected murder
Optician fined for molesting man in dim examination room
For a hopping great time where else but Kangaroo Island!
Push for encryption law falters despite Apple case spotlight
Sarawak Laksa draws a lot of attention from Singaporeans
M'sian Embassy holds charity do
Copyright © 1995- Star Media Group Berhad (ROC 10894D)


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text:
Lyrics matching 'total eclipse of the heart (tagalog) lyrics':
Eclipse of the Son Lyrics [Stryper]
From album: Murder by Pride
(Verse 1) I've been running nowhere street I've got to mend my bloody feet I've thrown away ten thousand days ...
Insomnia (tagalog version) Lyrics [Craig David/Wheesung]
oohhh di mo ba alam na ika'y mahal ko ooh di mo ba ramdam o sadya namang manhid ka lang di akalaing maiin love love lov...
Heart Heart Heartbreak Lyrics [Boys Like Girls]
From album: Love Drunk
Heartbreak Heart Heart Heartbreak You'll go say you love me and you're out the door (whoah, yeah) Cause I know things a...
Drive Away My Heart Lyrics [Ida Maria]
From album: Fortress Round My Heart
Fear is no longer hanging around
You should capture my view
Cause I don't want nothing else but you
You'll Be In My Heart Lyrics [Celtic Woman]
From album: Songs From The Heart
Come stop your crying It will be all right Just take my hand Hold it tight I will protect you from all around you ...
Breakin' My Heart Lyrics [Lil Wayne]
(feat. Little Brother) Hey baby look here, I got this new song I wrote, it's got that nice slow groove that everybody ...
My Heart Was Set On You Lyrics [Sutton Foster]
From album: Wish
My mother told me to break up with you, she didn't think you were good enough to take this prize, she didn't see any sp...
Black Heart Lyrics [Chimaira]
Black heart dead soul
Apathy and misery
Loss of control
Any of the above would describe me
My Heart Sings Lyrics [311]
From album: Uplifter
4 AM, this hotel room and I think of you
Not in anger, but in danger of calling you
My mind's a long lo...
I Heart ? Lyrics [Taylor Swift]
Wish I had concentrated,
They said love was complicated,
But it's something I just fell into,
Explore other songs:
- total eclipse of the heart (t...
- All The Way Turnt Up Lyrics t...
- swag surf remix lyrics by f.l.y
- Sweet Inspiration lyrics R & B
- Cocaine album lyrics by z-ro
- hot shot-superman with lyrics
- lyrics to dirt nasty
- folk song lubi lubi lyrics an...
- behind blue eyes lyrics by th...
- tey songz jupiter star love l...
- digital girl ft drake kanye w...
- cahnges in my life lyrics tag...
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- lyrics of shilla ki jawani song
- fabolous freestyle cypher lyrics
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Disclaimer: All artists, albums and lyrics are property and copyright of their owners. All lyrics provided for educational purposes only.


text:
A short history of the mass strike of miners in Nazi-occupied northern France from 27 May to 10 June. Despite heavy repression it won improvements to pay and conditions.
Article about the impact of the ideas of Syrian anarchist Omar Aziz in encouraging community self-organisation in the Syrian uprising, prior to the start of the civil war. Tragically he died in prison in 2013, aged 63.
A short biography of Giuseppe Impastato, a communist anti-Mafia activist who was murdered by the crime organisation in 1978, but was originally blamed for his own death by the police and the media.
A general strike of the tobacco workers and other unions on May 8th 1936 led to the bloody events of May 9th. The police confronted the massive strike by opening fire on the protesters. 12 dead and hundreds of wounded in one of the most important days in greek working class history.
An account of the growth of the Working Class movement in England and the United Kingdom, from the middle ages to the 1890's.
A short history of the massacre in Puerto Rico of peaceful demonstrators calling for the release of imprisoned separatist leader Pedro Campos by police acting on the orders of the US-appointed governor.
A contemporary and critical account of the 20th century history of Central America, in particular the conflicts between Leftist rebels and US backed right wing dictatorships in Nicaragua, El Salvador, and Guatemala.
A meticulously researched study into how the FBI attempted to disrupt and repress the civil rights movement in the US in the 1960s and 70s.
On the fifth anniversary of the fall of Egypt's president Mubarak, this is an account of the uprising, and the ebb and flow of the Egyptian revolution, by Wahid, an activist in Cairo.
A federal grand jury has ruled in favor of a black NYPD officer who was savagely beaten by police officers while he was at home celebrating his daughter's birthday in 2010.
Articles about state or employers repression and legal, police, military or paramilitary intimidation or violence against workers or social movements.
Revised edition of Philippe Bourrinet's history of the Dutch and German left communist currents.
In this text based on a presentation delivered in 1985 at a conference on the POUM held in Madrid, the former leader of the Iberian Communist Youth, and the last general secretary of the POUM,...
Assorted documents, press cuttings and flyers from the occupation of MDX University in 1991.
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Risk of Hepatotoxicity-Related Hospitalizations among Patients Treated with Opioid/Acetaminophen Combination Prescription Pain Medications
Version of Record online: 2 NOV 2010
DOI: 10.1111/j.1526-4637.2010.00979.x
Wiley Periodicals, Inc.
Pain Medicine
Volume 11, Issue 11, pages 1718–1725, November 2010
Additional Information
How to Cite
Duh, M. S., Vekeman, F., Korves, C., Lefebvre, P., Dial, E., Latremouille-Viau, D., Wei, R. S., Stangle, B. E., Lafeuille, M.-H., Michna, E. and Greenberg, P. E. (2010), Risk of Hepatotoxicity-Related Hospitalizations among Patients Treated with Opioid/Acetaminophen Combination Prescription Pain Medications. Pain Medicine, 11: 1718–1725. doi: 10.1111/j.1526-4637.2010.00979.x
Publication History
- Issue online: 2 NOV 2010
- Version of Record online: 2 NOV 2010
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Human Genetics (HUM GENET)
Journal description
Human Genetics is a monthly journal publishing original and timely articles on all aspects of human genetics. The Journal welcomes articles in the areas of Gene structure and organization Gene expression Mutation detection and analysis Linkage analysis and genetic mapping Physical mapping Cytogenetics and Genomic Imaging Genome structure and organisation Disease association studies Molecular diagnostics Genetic epidemiology Evolutionary genetics Developmental genetics Genotype-phenotype relationships Molecular genetics of tumorigenesis Genetics of complex diseases and epistatic interactions and Bioinformatics. Articles reporting animal models relevant to human biology or disease are also welcome. Preference will be given to those articles which address clinically relevant questions or which provide new insights into human biology. Unless they report entirely novel and unusual aspects of a topic clinical case reports cytogenetic case reports papers on descriptive population genetics articles dealing with the frequency of polymorphisms or additional mutations within genes in which numerous lesions have already been described will normally not be accepted. The Journal will not normally consider for publication manuscripts that report merely the isolation map position structure and tissue expression profile of a gene of unknown function unless the gene is of unusual interest or is a candidate gene involved in a human trait or disorder. Data on novel pathological mutations may be submitted to Human Genetics Online the electronic mutation data submission system administered by Springer-Verlag (
Current impact factor: 4.82
Impact Factor Rankings
|2016 Impact Factor
|Available summer 2017
|2014 / 2015 Impact Factor
|2013 Impact Factor
|2012 Impact Factor
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|2010 Impact Factor
|2009 Impact Factor
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Impact factor over time
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|Human Genetics website
|Other titles
|Human genetics (Online), Hum genet
|Material type
|Document, Periodical, Internet resource
|Document type
|Internet Resource, Computer File, Journal / Magazine / Newspaper
Publisher details
- Pre-print
- Author can archive a pre-print version
- Post-print
- Author can archive a post-print version
- Conditions
- Author's pre-print on pre-print servers such as arXiv.org
- Author's post-print on author's personal website immediately
- Author's post-print on any open access repository after 12 months after publication
- Publisher's version/PDF cannot be used
- Published source must be acknowledged
- Must link to publisher version
- Set phrase to accompany link to published version (see policy)
- Articles in some journals can be made Open Access on payment of additional charge
- Classificationgreen
Publications in this journal
Article: IL8 gene as modifier of cystic fibrosis: unraveling the factors which influence clinical variability[Show abstract] [Hide abstract] ABSTRACT: The severity of cystic fibrosis (CF) is associated with classes of mutations in the CFTR gene (cystic fibrosis transmembrane regulator), physical environment and modifier genes interaction. The IL8 gene (interleukin 8), according to its respective polymorphisms, influences inflammatory responses. This study analyzed IL8 gene polymorphisms (rs4073, rs2227306 and rs2227307), by means of PCR/RFLP, and their association with pulmonary function markers and clinical severity scores in 186 patients with CF, considering the CFTR genotype. There was an association between rs2227307 and precocity of the disease. The severity of lung disease was associated with the following markers: transcutaneous arterial hemoglobin oxygen saturation (SaO2) (regardless of CFTR genotype, for the polymorphisms rs4073, rs2227306 and rs2227307); mucoid Pseudomonas aeruginosa (regardless of CFTR genotype, for the polymorphisms rs2227306 and rs2227307). Pulmonary function markers (SaO2 and spirometric variables) and clinical severity scores were also associated with IL8 gene polymorphisms. This study identified the IL8 gene, represented by rs4073 and rs2227306 polymorphisms, and particularly the rs2227307 polymorphism, as potentiating factors for the degree of variability in the severity of CF, especially in pulmonary clinical manifestation correlated with increased morbidity and mortality.
- [Show abstract] [Hide abstract] ABSTRACT: In the last decade, there has been a flood of new technology in the sequencing arena. The onset of next-generation sequencing (NGS) technology has resulted in the vast increase in genetic diagnostic testing available to the ordering physician. Whole exome sequencing (WES) has become available as a diagnostic test performed in certified clinical laboratories. This has led to increased presence in the diagnostic marketplace, increased consumer awareness, and the question has been raised by various stakeholders to whether there is sufficient stringent regulation of WES and other NGS-based tests. We discuss the various WES services currently available in the marketplace, current regulation of WES as a laboratory developed test, the proposed FDA involvement in its oversight as well as the response of various laboratory groups that provide these diagnostic services. Overall, a rigorous process oversight and assessment of inter-lab reproducibility is strongly warranted for WES as it is used as a diagnostic test, but regulation should be mindful of the excessive administrative burden on academic and smaller diagnostic laboratories.
Article: The expanding phenotypic spectrum of female SLC9A6 mutation carriers: a case series and review of the literature[Show abstract] [Hide abstract] ABSTRACT: Christianson syndrome (OMIM 300243), caused by mutations in the X-linked SLC9A6 gene, is characterized by severe global developmental delay and intellectual disability, developmental regression, epilepsy, microcephaly and impaired ocular movements. It shares many common features with Angelman syndrome. Carrier females have been described as having learning difficulties with mild to moderate intellectual disability, behavioural issues and psychiatric illnesses. There is little literature on the carrier female phenotype of Christianson syndrome. We describe a large extended family with three affected males, four carrier females, one presumed carrier female and one obligate carrier female with a c.190G>T, p.E64X mutation known to cause a premature stop codon in SLC9A6. We characterize and expand the clinical phenotype of female SLC9A6 mutation carriers by comparing our described family with female carriers previously discussed in the literature. In particular, we highlight the neurodevelopmental and psychiatric phenotypes observed in our family and previous reports.
Article: Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients[Show abstract] [Hide abstract] ABSTRACT: Molybdenum cofactor (MoCo) deficiency is a rare, autosomal-recessive disorder, mainly caused by mutations in MOCS1 (MoCo deficiency type A) or MOCS2 (MoCo deficiency type B) genes; the absence of active MoCo results in a deficiency in all MoCo-dependent enzymes. Patients with MoCo deficiency present with neonatal seizures, feeding difficulties, severe developmental delay, brain atrophy and early childhood death. Although substitution therapy with cyclic pyranopterin monophosphate (cPMP) has been successfully used in both Mocs1 knockout mice and in patients with MoCo deficiency type A, there is currently no Mocs2 knockout mouse and no curative therapy for patients with MoCo deficiency type B. Therefore, we generated and characterized a Mocs2-null mouse model of MoCo deficiency type B. Expression analyses of Mocs2 revealed a ubiquitous expression pattern; however, at the cellular level, specific cells show prominent Mocs2 expression, e.g., neuronal cells in cortex, hippocampus and brainstem. Phenotypic analyses demonstrated that Mocs2 knockout mice failed to thrive and died within 11 days after birth. None of the tested MoCo-dependent enzymes were active in Mocs2-deficient mice, leading to elevated concentrations of purines, such as hypoxanthine and xanthine, and non-detectable levels of uric acid in the serum and urine. Moreover, elevated concentrations of S-sulfocysteine were measured in the serum and urine. Increased levels of xanthine resulted in bladder and kidney stone formation, whereas increased concentrations of toxic sulfite triggered neuronal apoptosis. In conclusion, Mocs2-deficient mice recapitulate the severe phenotype observed in humans and can now serve as a model for preclinical therapeutic approaches for MoCo deficiency type B.
- [Show abstract] [Hide abstract] ABSTRACT: Autism spectrum disorder (ASD) is characterized by substantial phenotypic and genetic heterogeneity, which greatly complicates the identification of genetic factors that contribute to the disease. Study designs have mainly focused on group differences between cases and controls. The problem is that, by their nature, group difference-based methods (e.g., differential expression analysis) blur or collapse the heterogeneity within groups. By ignoring genes with variable within-group expression, an important axis of genetic heterogeneity contributing to expression variability among affected individuals has been overlooked. To this end, we develop a new gene expression analysis method-aberrant gene expression analysis, based on the multivariate distance commonly used for outlier detection. Our method detects the discrepancies in gene expression dispersion between groups and identifies genes with significantly different expression variability. Using this new method, we re-visited RNA sequencing data generated from post-mortem brain tissues of 47 ASD and 57 control samples. We identified 54 functional gene sets whose expression dispersion in ASD samples is more pronounced than that in controls, as well as 76 co-expression modules present in controls but absent in ASD samples due to ASD-specific aberrant gene expression. We also exploited aberrantly expressed genes as biomarkers for ASD diagnosis. With a whole blood expression data set, we identified three aberrantly expressed gene sets whose expression levels serve as discriminating variables achieving >70 % classification accuracy. In summary, our method represents a novel discovery and diagnostic strategy for ASD. Our findings may help open an expression variability-centered research avenue for other genetically heterogeneous disorders.
- [Show abstract] [Hide abstract] ABSTRACT: Clinical exome sequencing has clearly improved our ability as clinicians to identify the cause of a wide variety of disorders. Prior to exome sequencing, a majority of patients with apparent syndromes never received a specific molecular genetic diagnosis despite extensive diagnostic odysseys. Even for those receiving an answer to the question of what caused their disorder, the diagnostic odyssey often spanned years to decades. Determining the particular genetic cause in an individual patient can be challenging due to inherent phenotypic and genetic heterogeneity of disease, technical limitations of testing or both. Blended phenotypes, due to multiple monogenic disorders in the same patient, are true dilemmas for traditional genetic evaluations, but are increasingly being diagnosed through clinical exome sequencing. New sequencing technologies have increased the proportion of patients receiving molecular diagnoses, while significantly shortening the time scale, providing multiple benefits for the health-care team, patient and family.
Article: Biological findings from the PheWAS catalog: focus on connective tissue-related disorders (pelvic floor dysfunction, abdominal hernia, varicose veins and hemorrhoids)[Show abstract] [Hide abstract] ABSTRACT: Pelvic floor dysfunction, specifically genital prolapse (GP) and stress urinary inconsistency (SUI) presumably co-occur with other connective tissue disorders such as hernia, hemorrhoids, and varicose veins. Observations on non-random coexistence of these disorders have never been summarized in a meta-analysis. The performed meta-analysis demonstrated that varicose veins and hernia are associated with GP. Disease connections on the molecular level may be partially based on shared genetic susceptibility. A unique opportunity to estimate shared genetic susceptibility to disorders is provided by a PheWAS (phenome-wide association study) designed to utilize GWAS data concurrently to many phenotypes. We searched the PheWAS Catalog, which includes the results of the PheWAS study with P value < 0.05, for genes associated with GP, SUI, abdominal hernia, varicose veins and hemorrhoids. We found pronounced signals for the associations of the SLC2A9 gene with SUI (P = 6.0e-05) and the MYH9 gene with varicose veins of lower extremity (P = 0.0001) and hemorrhoids (P = 0.0007). The comparison of the PheWAS Catalog and the NHGRI Catalog data revealed enrichment of genes associated with bone mineral density in GP and with activated partial thromboplastin time in varicose veins of lower extremity. In cross-phenotype associations, genes responsible for peripheral nerve functions seem to predominate. This study not only established novel biologically plausible associations that may warrant further studies but also exemplified an effective use of the PheWAS Catalog data.
- [Show abstract] [Hide abstract] ABSTRACT: Intratumor heterogeneity within individual cancer tissues underlies the numerous phenotypes of cancer. Tumor subclones ultimately affect therapeutic outcomes due to their distinct molecular features. Drug-resistant subclones are present at a low frequency in tissues at the time of biopsy, but can also arise as a result of acquired somatic mutations. A number of different approaches have been utilized to understand the nature of intratumor heterogeneity. Clonal analysis using whole exome or genome sequencing data can help monitor subclones in the context of tumor progression. Multiregional biopsies permit the molecular characterization of subclones within tumors. Deep sequencing has also provided researchers with the ability to measure the low allele fraction variant within a small number of cells. Ultimately, single-cell sequencing will enable the identification of every minor population within a tumor microenvironment. In the clinical context, the ability to identify and monitor the subclonal architecture of a tumor is valuable for the development of precise cancer therapeutic methods.
- [Show abstract] [Hide abstract] ABSTRACT: Intellectual disability (ID) is one of the most common disabilities and, although many genes have been implicated in its etiology, the genetic heterogeneity of ID continues to expand. The purpose of the study was to describe a novel autosomal recessive non-syndromic ID locus. Autozygome and linkage analysis, and exome sequencing followed by RNA and protein analysis of the candidate disease gene were performed. We describe two multiplex consanguineous families with non-syndromic ID phenotype, which maps to a critical linkage locus on 3q26. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik −/− phenotype in the murine model. Our data strongly implicate TNIK deficiency in the causation of ID in humans.
Article: An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability[Show abstract] [Hide abstract] ABSTRACT: Microdeletion syndromes are frequent causes of neuropsychiatric disorders leading to intellectual disability as well as autistic features accompanied by epilepsy and craniofacial anomalies. From comparative deletion mapping of the smallest microdeletion to date at 12q24.31, found in a patient with overlapping clinical features of 12q24.31 microdeletion syndrome, we narrowed the putative critical region to 445 kb containing seven genes, one microRNA, and one non-coding RNA. Zebrafish in situ hybridization and comprehensive transcript analysis of annotated genes in the panels of human organ and brain suggest that these are all candidates for neurological phenotypes excluding the gene HPD. This is also corroborated by synteny analysis revealing the conservation of the order of these six candidate genes between humans and zebrafish. Among them, we propose histone demethylase KDM2B and histone methyltransferase SETD1B as the two most plausible candidate genes involved in intellectual disability, autism, epilepsy, and craniofacial anomalies. These two chromatin modifiers located approximately 224 kb apart were both commonly deleted in six patients, while two additional patients had either KDM2B or SETD1B deleted. The four additional candidate genes (ORAI1, MORN3, TMEM120B, RHOF), a microRNA MIR548AQ, and a non-coding RNA LINC01089 are localized between KDM2B and SETD1B. The 12q24.31 microdeletion syndrome with syndromic intellectual disability extends the growing list of microdeletion syndromes and underscores the causative roles of chromatin modifiers in cognitive and craniofacial development.
- [Show abstract] [Hide abstract] ABSTRACT: Sarcoidosis is a multisystem granulomatous disorder that causes significant morbidity. Genetic factors contribute to sarcoidosis risks. In this study, we investigated whether copy number variations (CNVs) of FCGR3A (coding for FcγRIIIA) and FCGR3B (coding for FcγRIIIB) genes are associated with sarcoidosis susceptibility and whether the expressions of FcγRIIIA on NK cells and FcγRIIIB on neutrophils are altered in sarcoidosis patients. TaqMan real-time PCR assays were used to analyze the CNV of FCGR3A and FCGR3B genes. FCGR3A and FCGR3B CNV genotypes were compared between 671 biopsy-proven sarcoidosis patients and the same number of healthy controls matched with age, sex, race, and geographic area from the ACCESS (A Case Control Etiologic Study of Sarcoidosis) cohort. Flow cytometry analyses were used to determine expressions of FcγRIIIA on NK cells and FcγRIIIB on neutrophils in phenotype analyses. We found that FCGR3A CNVs were significantly associated with sarcoidosis in females (CN = 1 vs. CN = 2 logistic regression adjusted for sex and race, OR 4.0156, SE = 2.2784, P = 0.0143; CN = 3 vs. CN = 2 logistic regression adjusted for sex and race, OR 2.8044, SE = 1.1065, P = 0.0090), suggesting that FCGR3A gene abnormality influences sarcoidosis development in a gender-specific manner. Furthermore, FcγRIIIA expressions were significantly decreased on NK cells from sarcoidosis patients compared to those from healthy controls (P = 0.0007). Additionally, low FCGR3B CN was associated with sarcoidosis (CN <2 vs. CN = 2 logistic regression adjusted for sex and race, OR 1.5025, SE = 0.2682, P = 0.0226), indicating that the functions of FCGR3B gene may also contribute to the pathogenesis of sarcoidosis. We conclude that FCGR3A CNVs are a major risk factor for female sarcoidosis and FCGR3B CNVs may also affect the development of sarcoidosis.
Article: A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition[Show abstract] [Hide abstract] ABSTRACT: Intellectual disability is a common and highly heterogeneous disorder etiologically. In a multiplex consanguineous family, we applied autozygosity mapping and exome sequencing and identified a novel homozygous truncating mutation in PUS3 that fully segregates with the intellectual disability phenotype. Consistent with the known role of Pus3 in isomerizing uracil to pseudouridine at positions 38 and 39 in tRNA, we found a significant reduction in this post-transcriptional modification of tRNA in patient cells. Our finding adds to a growing list of intellectual disability disorders that are caused by perturbation of various tRNA modifications, which highlights the sensitivity of the brain to these highly conserved processes.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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'Ecommerce FDI violation case still relevant'
According to the regulation, ecommerce entities providing marketplace must maintain level playing field for all sellers.
'E-commerce fastest growing sector globally'
In and exclusive chat with ET Now, Pavan Sondur, Co-founder and CEO, Unbxd, talks about the comp...
China to open e-commerce, other sectors to foreign investment
China will lift restrictions to investments by foreign firms in a range of serv...
Tata Group enters e-commerce space with Tata Cliq
India's biggest conglomerate Tata Group launched an e-commerce venture, as it seeks to cash in on rising purchasing power in a market dominated by deep-pocketed international retailers and startups backed by global tech investors.
Tata Group enters e-commerce market with apparel, electronics website
To keep costs in check, Pandey said Tata would use its money establishing a large number of warehouses like other e-commerce players have done.
Ecommerce companies say GST will be taxing for customers
The recommendations include defining ecommerce appropriately to remove the ambiguity and confusion with "aggregator" and "intermediary" under indirect tax laws.
China's Tiens Group to enter Indian e-commerce market
Founded in 1995 by Li Jinyuan in Tianjin city of northern China, Tiens group has presence in fields like biotechnology, education, retail, tourism, finance and e-business.
'Funding squeeze causing stricter evaluation of e-commerce models'
Further, the current wave of consolidation among e-commerce players may intensify, leading to fewer, stronger players emerging within each category.
Jewellery to e-commerce, time for discounts!
From gold coins to i phones, all this u can get as freebies take a look at this special reports.
Iyengars' Bakery believes e-commerce is the need of the hour
A slew of Bengaluru's iconic old-world restaurants including the iconic Iyengar's bakery have taken the technology route. Find out more.
B2B e-commerce market 6 times larger than B2C: SME lenders
The lenders say B2B e-commerce could become their strongest segment by 2017, as they estimate 25-30% of the profit to come from this space.
How local tailors are partnering with ecommerce firms like Myntra, Abof.com to fix fitting flaws
The local 'darzi' is back in demand, being wooed by both online, offline retail cos that want to mend a sales gap that's caused every time ill-fitting clothes are returned.
Amazon India's growth threatens to unsettle ecommerce firms like Flipkart and Snapdeal
ET reported on April 28 that Amazon India was the only major online marketplace to register an increase in unit market share in March.
Ray-Ban converts India website into ecommerce platform to curb fakes
Ray-Ban has converted its India website into an ecommerce platform, as the eyewear brand seeks to fight off counterfeits that flood online marketplaces.
Another one bites the dust in ecommerce space! Now Anand Chandrasekaran quits Snapdeal
The company declined to provide details on who will be heading the position on his behalf. Chandrasekaran's next move has not been disclosed.
Start up Central: E-Commerce under the scanner
According to the reports the retailer association is soon going to seek an enforcement directorate probe into the voilation by the e-tailers.
Tata's e-commerce portal ties up with Genesis for exclusive luxury brands
The partnership is a testament to providing the Indian consumer authentic brand experiences directly through authorized sellers and not unknown resellers.
Snapdeal claims to offer fastest deliveries in ecommerce, says it is ahead of Flipkart, Amazon
An April report by Red Seer said Snapdeal had the fastest average delivery time of 3.9 days, followed by Amazon at 4.1 days and Flipkart at 5.1 days.
Amazon in discussions with government on ecommerce rules; seeks clause allowing promotions
Amazon exes also made a point on direct interface with customers. "If we are not allowed to interface with customers, then how will we do business?"
More ecommerce will trigger big innovations in India: Study
"We are engaging with the government in states and at the Centre to help create an enabling environment for the industry," Viresh Oberoi said.
Arvind in talks to acquire Sequoia Capital-funded ecommerce company Freecultr
Textile-to-retail conglomerate Arvind is in advanced talks to acquire Sequoia Capitalfunded ecommerce company Freecultr.
RSS affiliate SJM to oppose FDI in e-commerce, food processing
The SJM leader said there are nearly 2,000 small and big portals involved in e-commerce, though most most transactions are limited to a few big ones.
Ecommerce breathes life into obituaries startups
As per a market survey by Tributes. in, the newspaper obituary and remembrance advertisement market size is estimated at more than Rs 350 crore annually from the top 100 cities in India.
E-commerce companies benefiting customers while promoting competition: FM Arun Jaitley
Jaitley said innovative technology being used by e-commerce companies were benefiting the customers while promoting competition.
CAIT alleges Flipkart violated e-Commerce FDI norms
Traders' body CAIT today filed a complaint with the Department of Industrial Policy & Promotion alleging violation of FDI norms for e-Commerce by Flipkart.
Tata Group set to enter ecommerce space through the launch of online marketplace CLiQ
The Tata Group's entry follows online forays by several established conglomerates. Last week, Arvind Ltd launched its omni-channel platform NNNow.com.
Despite low internet use, India's e-commerce market triples in five years
The Goods and Services Tax, once implemented, is expected to boost the growth of e-commerce by simplifying taxation and logistics, said the CII-Deloitte report.
'E-commerce space in India is buzzing'
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Offline retailers ask for enforcement of FDI norms in ecommerce
India's brick-and-mortar retailers are lobbying the government to make sure that ecommerce companies follow the new marketplace norms, seeking further clarifications.
India Handloom Brand bets on ecommerce to raise market positioning
India Handloom Brand is drawing up new strategies that include retail and ecommerce, in a bid to raise the market positioning of handloom.
E-commerce boom: Investors turn focus to profitable growth
As the e-commerce market grew by leaps and bounds in the last four years, investors have shifted their focus to profitable growth to achieve stability, a CII-Deloitte report says.
E-commerce, technology startups to dominate hiring landscape: TeamLease report
According to the TeamLease Employment Outlook Report, the increase in consumer spending and the renewed focus on market expansion will have a positive impact on hiring.
Nokia bets on India's e-commerce sector to grow analytics, applications business
The former handset maker is also building an IoT centre of excellence in Bengaluru, spending $10-30 million on the facility.
Online e-commerce company JD.com's revenue jumps 47 per cent
JD.com Inc, China's No.2 e-commerce company, reported a 47 percent rise in revenue, helped by higher volume of sales on its platforms.
Phase of exuberance in e-commerce sector over: Mohandas Pai
Pai, ex-CFO of software major Infosys, said 2015 was a year of exuberance as a lot of money flowed into the sector but it is no longer the scene now.
Amicus Curiae: E-commerce biz redefined
Watch the panel of experts on a revamped e-commerce policy taken by govt.
E-commerce space in India is very challenging: Punit Soni
Former Flipkart CPO, Punit Soni spills the beans about his new plans. Punit played a crucial role in launching chat feature ping as well as mobile push. He stated that the e-commerce space in India is indeed very challenging.
B2B e-commerce platforms have taken wholesale mandis online
Sanjiv Khandelwal has found that people are increasingly taking to smartphones for price discovery and the offline 'mandis' are becoming irrelevant.
India's e-commerce sector to see $120 billion revenue by 2020: Assocham-Forrester report
The increase would be mainly on the back of young demographic profile, rising Internet penetration and relatively better economic performance,, it said.
E-commerce giant Flipkart to scale down contribution of WS Retail
WS Retail, owned by Flipkart's founders until 2012, currently dominates the platform and is said to have a share that well exceeds 25% of total sales.
Fintech operation will be many times bigger than ecommerce: Paytm's Vijay Shekhar Sharma
Vijay Shekhar Sharma is planning to spin off his ecommerce division, where Alibaba will call most of the shots, and focus his energies on financial services.
E-commerce giant Flipkart to scale down contribution of WS Retail
WS Retail, owned by Flipkart's founders until 2012, currently dominates the platform and is said to have a share that well exceeds 25% of total sales.
Bajaj Finserv to offer new 'EMI' option on ecommerce platform
On the ecommerce platform, the EMI would apply on the total order value and could be split across several products across different categories.
E-commerce company flouting FDI norms? Vendors protest against Paytm's cashback model
The department of industrial policy & promotion in response to the query raised in Twitter clarified that giving discount is a prerogative of the seller only.
Flipkart's logistics arm does business for rivals and is even looking beyond ecommerce
When Sachin and Binny Bansal founded Flipkart in 2007, they often ended up jumping on their own vehicles in the initial months to make deliveries.
IAMAI welcomes 100% FDI in e-commerce
IAMAI said in a statement allowing 100% FDI under automatic route in online marketplace model will usher in considerable investments and will benefit the consumers.
Alibaba buys control of Lazada in $1 billion bet on southeast Asia ecommerce
Alibaba Group Holding Ltd has agreed to buy a controlling stake in Southeast Asian online retailer Lazada Group for about $1 billion.
How e-commerce startups are helping small businesses go online
Startups have figured out that an online identity without dynamic inventory management and payment gateway is not a recipe for success.


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CoMentis, Inc. is focused on the research and development of small molecule drugs to treat CNS disorders. The company, with headquarters in South San Francisco, was founded based on the groundbreaking discoveries on structure, function, and inhibition of the beta-secretase enzyme by Jordan Tang, Ph.D., J.G. Puterbaugh Chair in Biomedical Research at the Oklahoma Medical Research Foundation and Arun K. Ghosh, Ph.D., Ian P. Rothwell Distinguished Professor - Organic Chemistry/Medicinal Chemistry at Purdue University.
CoMentis is developing an orally administered disease-modifying treatment for Alzheimer's disease that inhibits the beta-secretase enzyme to reduce the formation of beta amyloid peptides, thereby preventing deleterious effects of accumulated amyloid peptides and downstream pathologies. Beta amyloid peptides aggregate to form soluble polymers and insoluble plaques in the brain, implicated in the development of Alzheimer's disease. Inhibition of beta-secretase reduces amyloid beta production and could block the progression of Alzheimer's disease.
CoMentis is currently pursuing the development of beta-secretase inhibitor drugs in partnership with Astellas Pharma, Inc., under terms of an exclusive worldwide collaboration agreement initiated in 2008.


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The Big Six: The CIO Executive Council's Frameworks for IT Value and Leadership
This overview of six of the CIO Executive Council's most important pieces of intellectual capital represents the thought leadership of literally hundreds of global CIOs spanning over half a decade. It is intended to convey the Council's position on the current and future CIO role and the value that IT should be creating for the enterprise. We hope that it offers the IT community an intriguing and comprehensive roadmap for continued success.
Please supply your email address to access the content.
Market Place
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Autoharpoonby The Salty Dogs
From the band name and punny album title, one would be forgiven for expecting the Salty Dogs' Autoharpoon to be, say, maritime folk-punk songs from Newfoundland about the drunken adventures of whalers or something like that. In fact, the Salty Dogs are an Arkansas quartet proffering pure old-fashioned honky tonk country in the great tradition of early Ray Price and the Bakersfield posse. Singer/songwriter Brad Williams knows his two-steps and shuffles, and he and the band, especially lap steel specialist Nick Devlin, alternate between cry-in-your-beer ballads like the downright Victorian "The People Cried" and more uptempo twangers like "Starting Now," featuring a guest shot from Elvis Presley's drummer D.J. Fontana. Other highlights include a crisp, unfussy extended workout on the country blues classic "Take Time to Know Her" and the unexpected art move of the two-part closer, "Heaven's Gates/Hell's Flames." Autoharpoon is unpretentious, joyous, and as pure as mountain dew.
Product Details
- Release Date:
- 05/15/2007
- Label:
- Big Bender Records
- 0742187543825
- catalogNumber:
- 75438
Album Credits
Performance CreditsSalty Dogs Primary Artist
Nick Devlin Autoharp,Electric Guitar,Vocals,Background Vocals,Lap Steel Guitar
D.J. Fontana Drums,Guest Appearance
Virginia Williams Background Vocals,Guest Appearance
Mike Nelson Synthesizer,Bass,Percussion,Hand Clapping,Wurlitzer,Arp Omni
Brad Williams Acoustic Guitar,Mandolin,Percussion,Electric Guitar,Vocals,Background Vocals,Hand Clapping
Kelly Duda Hand Clapping,Guest Appearance
Technical CreditsMickey Newbury Composer
Bucky Barrett Engineer
Steve Davis Composer
Isaac Alexander Artwork
Mike Nelson Engineer
Brad Williams Composer
Customer Reviews
Average Review:
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >


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Global News
GMC Introduces Yukon SLT Premium Edition
GMC today announced the 2016 Yukon SLT Premium Edition – a chrome-trimmed special model offering a premium, personalized appearance on SLT models.
DETROIT (Tuesday, March 22, 2016) – GMC today was recognized as the Most Refined Brand in the 2016 Kelley Blue Book Brand Image Awards. It is the third consecutive year the brand has received this award.
OSHAWA (Wednesday, February 24, 2016) –The GMC brand gained five spots, moving up to No. 5 overall in the 2016 J.D. Power Vehicle Dependability Study while the Yukon full-size SUV ranked highest in its segment.
Oshawa, Ontario (Tuesday, October 20, 2015) – After two days of competition and rugged testing, the 2016 GMC Canyon Diesel emerged as the winner of the midsize pickup truck segment at the 9th iteration of the Canadian Truck King competition.
DETROIT (Monday, April 13, 2015) – The all-new GMC Canyon was the top pick by the editors of Cars.com in a midsize pickup comparison test posted today.
DETROIT (Thursday, February 26, 2015) – The GMC Sierra 1500 full-size light-duty pickup, Yukon full-size SUV and Terrain compact SUV ranked highest in their respective segments in the 2015 J.D. Power Vehicle Dependability Study. The GMC brand gained six spots, moving up to No. 10 overall (in a tie).
DETROIT – For the first time, Chevrolet, Buick, GMC and Cadillac all rank in the top 10 among brands in the J.D. Power Vehicle Dependability Study.
DETROIT (Tuesday, December 16, 2014) – GMC Canyon today was named Autoweek's Best of the Best/Truck for 2015. Editors praised the all-new premium midsize truck for its design, utility, features and "perfect size."
OSHAWA, ON (November 4, 2014) — GM Canada has been selected as one of Canada's "Top 100 Employers" by Mediacorp Canada Inc. in its annual survey of Canadian businesses. This is the fourth consecutive year that GM Canada has been included.
Oshawa, Ontario (Thursday, July 24, 2014) – The 2014 GMC Yukon ranked highest in its segment in the J.D. Power Automotive Performance, Execution and Layout StudySM released today. Yukon was also recently recognized by J.D. Power in both the Initial Quality and Vehicle Dependability Studies.
DETROIT – General Motors continues its strong performance in the J.D. Power Initial Quality StudySM taking more initial quality awards than any other automaker for the second year in a row. GM also has the most models ranked in the top three in their respective segments.
DETROIT (Monday, April 14, 2014) – The new 2014 GMC Sierra Denali pickup truck is a cut above the rest. In addition to being the most powerful, most advanced and most refined truck in the brand's 111-year history, it was named to Ward's 10 Best Interiors of 2014.
Oshawa, Ontario (Tuesday, April 08, 2014) – The Canadian built Chevrolet Equinox and GMC Terrain with available forward collision alert technology, earned 2014 Top Safety Pick+ ratings from the Insurance Institute for Highway Safety in the United States, the only midsize SUVs of nine evaluated to earn Good ratings in the Institute's small overlap front crash test.
DETROIT (Thursday, February 13, 2014) – General Motors has more segment award recipients than any other automaker in the J.D Power 2014 Vehicle Dependability Study, doubling last year's segment awards from four to eight across its four brands.
DETROIT (Friday, January 10, 2014)– The regular and double cab versions of 2014 Chevrolet Silverado 1500 and the GMC Sierra 1500 have received the highest possible 5-star Overall Vehicle Score for safety as part of the National Highway Traffic Safety Administration's New Car Assessment Program.
TORONTO (Tuesday, December 3, 2013) – GMC was honoured today by the Automobile Journalists Association of Canada (AJAC), which named the 2014 GMC Sierra the "Best New Pickup" in Canada.
DETROIT – The 2014 Chevrolet Silverado 1500 and High Country and the GMC Sierra and Sierra Denali 1500 are the first pickup trucks to receive the highest possible five-star Overall Vehicle Score for safety since the United States National Highway Traffic Safety Administration changed its New Car Assessment Program for the 2011 model year.
Toronto, ON (Thursday, February 14, 2013) – General Motors was honoured today at the Canadian International Auto Show when the Automobile Journalists Association of Canada (AJAC) named the Front Centre Airbag as the "2013 Best New Technology."
DETROIT – Truck Trend magazine says the GMC Sierra 2500HD and Silverado HD are the "Best in Class 2011 Work Truck" and GMC Yukon and Chevrolet Tahoe are judged "Best in Class 2011 Full-Size SUV."
DETROIT – The new 2011 Sierra Denali 3500HD on Monday was named the winner of PickupTrucks.com's Heavy-Duty Shootout, beating the 2011 Ford F-350 and 2010 Ram 3500 in the one-ton diesel category.
DETROIT -- Led by the Chevrolet Camaro, General Motors had five of the 10 most-successful all-new or totally redesigned vehicle launches in 2009, based on an analysis by Edmunds.com leading to the automotive information firm's first Launch Breakthrough Award.
Montréal Auto Show, Thursday, January 15, 2009 — Today, the Automobile Journalists Association of Canada (AJAC) recognized GM's Two-Mode Hybrid technology as the 2009 Best New Green Technology. The inaugural award results from AJAC's desire to recognize innovative new green technology developments in the auto industry that will be of benefit to the Canadian consumer.
GMC today announced the 2016 Yukon SLT Premium Edition – a chrome-trimmed special model offering a premium, personalized appearance on SLT models.


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|To be fair it looks like a simple typo.
#9804329, By mikew1985 Grand Theft Auto V
mikew1985 13,975 posts
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Overwatch guide Hero guides, map guides, mechanics and more!
Fallout 4: Far Harbor guide Quest walkthrough, how to get the Marine Armor, best weapons.
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|To be fair it looks like a simple typo.


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4 search results for of the blue color of the sky
Watch: OK Go's trippy vid for 'WTF?'
Type: Article | Date: Tuesday, Nov 17, 2009'Psycho-donkey' and a guy that yells 'balls' as loud as he could
A short history of Kanye West's obsession with Stanley Kubrick
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Jennifer Lawrence and Stephen Colbert look at the stars, ask Big Questions
Type: Article | Date: Tuesday, Dec 15, 2015Life and death and raccoons.
Vampire Weekend, OK Go lead Jan. 12 release slate
Type: Post | Date: Monday, Jan 11, 2010Ringo Starr gets a little help from his friends on 'Y Not'


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Do you want to make Ohio.com your homepage?
By Jason Lloyd
Beacon Journal sports writer
Cleveland Cavaliers' Earl Clark (6) drives to the basket against Charlotte Bobcats' Josh McRoberts (11) and Bismack Biyombo (0) in the second half of a game in Charlotte, N.C., in Nov. 2013. The Bobcats won 90-84. (AP Photo/Chuck Burton)
Cleveland Cavaliers' Jarrett Jack (1) makes a move to the basket as he is guarded by Orlando Magic's Jameer Nelson during the first half of a preseason game in Orlando, Fla., in Oct. 2013.(AP Photo/John Raoux)
Cleveland Cavaliers' Jarrett Jack (1) controls a loose ball against Minnesota Timberwolves' J.J. Barea (11) as time express in the fourth quarter of the Cavaliers' 93-92 win in a game in Nov. 2013, in Cleveland. The Cavaliers' Kyrie Irving (2) trails the play. (AP Photo/Mark Duncan)
Cleveland Cavaliers' Earl Clark (6) dunks against the Minnesota Timberwolves in the first quarter of a game Monday in Nov. 2013, in Cleveland. (AP Photo/Mark Duncan)
Cleveland Cavaliers' Andrew Bynum in action during a game against the Philadelphia 76ers in Nov. 2013, in Philadelphia. (AP Photo/Matt Slocum)
Phoenix Suns' Miles Plumlee (rear) and Brooklyn Nets' Kevin Garnett battle for the ball during the first half of a game, Friday in Phoenix. (AP Photo/Matt York)
Phoenix Suns' P,J, Tucker and Brooklyn Nets' Paul Pierce reach for a loose ball during the second half of a game, Friday in Phoenix. The Nets won 100-98 in overtime. (AP Photo/Matt York)
Click here to read or leave a comment(s) on this story.
TORONTO: LeBron James exited the game with three minutes left and began celebrating. He hugged his coach, hugged teammates and even hugged Raptors guard DeMar DeRozan. There was plenty of reason to celebrate.


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How Movies Lie To Us About Winter
Okay, did everyone survive the blizzard? After a weekend of blustery winds, drifting flurries, and subzero temperatures, you're all well versed in the fact that winter weather can be a big fat pain. Sure, it looks gorgeous — when you're staring at it out your window with flannel pajamas on, a steaming mug of hot chocolate in hand, and a New Girl marathon playing on Netflix. But, if you're out braving the elements — or worse, trying to commute to the job that refused to give you a snow day — it's anything but magical.
So, why hasn't Hollywood realized that? Maybe it's because the movie bigwigs are all safely ensconced in the balmy southern California climate, but we've noticed a major difference between the silver screen and reality lately. Romcoms (and even Disney movies) are constantly using snow to create iconically romantic scenes, but the cynic inside of us just has to cry foul. Ahead, five of our favorite snowy scenes and how they would truly go down in real life.
Bridget Jones's Diary
The Real Talk: Let's forget the fact that Bridget isn't even wearing pants for a minute. What we want to know is: What kind of traction does she have on those running shoes? We've worn everything from industrial-strength hiking boots to Hunters out in the snow, and they never keep us from wiping out. Then, add in the fact that you're going for a light jog? Lights out.
Beauty & The Beast
The Real Talk: We have to admit that we love this part of Beauty & The Beast. In fact, it's 20 years later and we still have every word of that song memorized. But, we have to point out that Belle is having a snowball fight while wearing nothing more than a dress and light cape. She doesn't even have full sleeves, much less gloves. Sure, the Beast is doing it too, but he's, you know, a beast. With fur.
The Real Talk: Ahh, the magic of the winter wedding. But, wait, it's on a New York City street. Where's the gray, half-melted slush? The cigarette butts in the snow drifts? The neighbor's dog marking its territory?
The Scene:
The Real Talk: Let's see here: Laying out on a soaking wet ice rink during a snowstorm for what is presumably hours, only to have the love of your life finally show up? Raise your hand if that would put you in a good mood. That's what we thought.
The Real Talk: We know this is one of the most romantic scenes of all time, but all we remember is Cher's classic line, "I'm gonna go home, I'm freezing to death!" You said it, sister. Sure, having a guy profess his undying love for you is romantic, but what's wrong with doing it, say, upstairs in his warm and cozy apartment?
- Entertainment |
- Movies | Movie Snow Scenes - Winter-Themed Romantic Comedies
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ICTUpdate - a current awareness bulletin for ACP Agriculture
Current issue: Special 50th issueMobile version
- Issue no. 50
- August 2009
EXPLORE ICT update
FEATURED TECHNOLOGY: Internet
Making stronger links..
Using the internet and mobile phones, small-scale farmers in East Africa are learning how to work efficiently with the traders who buy their goods. Linking Local......
The complete package..
Computers for Schools Kenya does more than just give away old computers. For them training, education, partnerships and policy change are just as important. Sinc......
New crops from old PCs..
Refurbished computers provide internet and e-learning to rural communities in Uganda. Farmers there have increased crop production and their annual income. ...
Spreading the net..
At the moment, there is very little evidence of web 2.0 tools being used at the community level in developing countries. In Senegal, for example, people can list.....
FEATURED Theme: Issue no. 76 - Mobile finance - next stop for agriculture
Reducing supply chain credi.....
A mobile platform called MoBiashara aims to reduce supply chain credit risk and compute an alternative credit scoring that promotes access to finance. ...
The agricultural mobile fin.....
Emerging innovations in mobile finance are revolutionising the agricultural value chain and giving farmers greater access to a range of financial services. ...
Beyond cash..
SmartMoney has grown from a small intervention targeting market inefficiencies between rural farmers and agriculture organisations to a community-wide rural payme......
Big data for smallholders..
The Financial Identity Risk Management solution will provide consumer protection while enabling lenders to offer credit that can improve a borrower's life and lif......
- Drones for agriculture
- The power of online communities
- More than Mobile
- Data Revolution for Agriculture
- Building resilience for family farming
- Linking farmers to markets
- Mobile finance - next stop for agriculture
- ICT4Ag: Making it happen - post-conference issue
- ICT4Ag: setting the scene - pre-conference issue
- e-agriculture strategies
- Open access & open data
- Small Islands
- Agricultural research and ICTs
- Crowdsourcing and engagement
- Women and ICTs
- ICT innovation
- A future for telecentres
- Youth and ICTs