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In this lyrical, unsentimental, and compelling memoir, the son of a black African father and a white American mother searches for a workable meaning to his life as a black American. It begins in New York, where Barack Obama learns that his father—a figure he knows more as a myth than as a…read more
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Nine years before the Senate campaign that made him one of the most influential and compelling voices in American politics, Barack Obama published this lyrical, unsentimental, and powerfully affecting memoir, which became a #1 New York Times bestseller when it was reissued in 2004. Dreams from My…read more
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The Audacity of Hope is Barack Obama's call for a new kind of politics—a politics that builds upon those shared understandings that pull us together as Americans. Lucid in his vision of America's place in the world, refreshingly candid about his family life and his time in the Senate,…read more
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arg1-9782757810897.html L?homme du nouveau r?ve am?ricain livre ses M?moires . Le 4 novembre auront lieu les ?lections pr?sidentielles am?ricaines. ? la cl?, le destin d?un homme qui incarne le r?ve am?ricain. N? de p?re kenyan et de m?re am?ricaine, il ne fait aucun doute que Barack Obama restera…read more
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En La audacia de la esperanza , el senador demócrata Barack Obama reclama una política diferente—una política para quienes están cansados del agrio partidismo, una política que se basa en la fe, la participación de todos y la nobleza de espíritu que es…read more
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Home > Press > Stanford researchers' magnetic nanotags spot cancer in mice earlier than current methods
Improved magneto-nano sensor chips are up to 1,000 times more sensitive than current methods of cancer detection - can scan any bodily fluid with high accuracy and search for up to 64 different cancer-associated proteins simultaneously.
Searching for biomarkers that can warn of diseases such as cancer while they are still in their earliest stage is likely to become far easier thanks to an innovative biosensor chip developed by Stanford University researchers.
The sensor is up to 1,000 times more sensitive than any technology now in clinical use, is accurate regardless of which bodily fluid is being analyzed and can detect biomarker proteins over a range of concentrations three times broader than any existing method, the researchers say.
The nanosensor chip also can search for up to 64 different proteins simultaneously and has been shown to be effective in early detection of tumors in mice, suggesting that it may open the door to significantly earlier detection of even the most elusive cancers in humans. The sensor also can be used to detect markers of diseases other than cancer.
"In the early stage [of a cancer], the protein biomarker level in blood is very, very low, so you need ultra-sensitive technology to detect it," said Shan Wang, professor of materials science and engineering and of electrical engineering, and senior author of a paper describing the sensor, which was published online on Nature Medicine's website on Oct. 11. "If you can detect it early, you can have early intervention and you have a much better chance to cure that person."
Wang said the nanosensor technology also could allow doctors to rapidly determine whether a patient is responding to a particular course of chemotherapy. "We can know on day two or day three of treatment whether it is working or not, instead of a month or two later," he said.
The sensor Wang and his colleagues have created, which uses magnetic detection nanotechnology they had developed previously, can detect a given cancer-associated protein biomarker at a concentration as low as one part out of a hundred billion (or 30 molecules in a cubic millimeter of blood).
Although the basics of the magnetic detection technology used in the new biosensor were described last year in a paper in the Proceedings of the National Academy of Sciences, the new sensor is not only more sensitive than the previous one by several orders of magnitude, it also outperforms its predecessor - and detection methods now in use - in several other ways.
Early detection of tumors in mice
The most impressive performance gain detailed in the Nature Medicine paper is that the researchers have now demonstrated that the magneto-nano sensor can successfully detect cancerous tumors in mice when levels of cancer-associated proteins are still well below concentrations detectable using the current standard methodology, known by the acronym ELISA.
"That is a critical finding for us because it says that in a realistic biological application - that of tumor growth in mice - we can actually see tumors before anything else could have detected them," said Sam Gambhir, professor of radiology at Stanford.
"I would say that the PNAS paper is proof of concept of the technology, and the Nature Medicine paper is proof of concept of the technology working in a real-world application," he said. "It is one thing to have the technology show that it can work in principle; it is quite another to actually utilize it with real mouse blood samples from a real mouse growing a real tumor."
In the Nature Medicine paper, the researchers show that the new magneto-nano sensor has a broad range of sensitivity, from the minute quantity described earlier to concentrations six orders of magnitude, or a million times, greater. The best existing analysis methods, or assays, in clinical use are able to detect proteins over a range of concentrations of at most two orders of magnitude.
Most of the sensing platforms currently in use are also limited to performing a single analysis at a time, but because the magneto-nano sensors are attached to a microchip in an array of 64 sensors, each of which can be set up to detect a different protein, the researchers can search for up to 64 different proteins simultaneously during a single analysis, which typically takes one to two hours - far less than most existing assays.
The researchers also demonstrated that the sensor is equally effective in every likely biological fluid, or matrix, that a doctor would want to analyze for cancer-associated proteins. Those fluids include urine, saliva, blood plasma (blood with the blood cells removed), serum (blood plasma with the factors that promote clotting removed) and cell lysates (the name applied to the cellular stew produced by dissolution of cells).
"The idea that you could essentially, on a single assay platform, measure a broad diversity of biomolecules that are at such a wide range of concentrations with such sensitivity is really, truly remarkable," said Charles Drescher, a professor of obstetrics and gynecology at the University of Washington in Seattle, who was not involved with the research. "I think we'll all be very excited if this really does pan out."
The key to the versatility of the magneto-nano sensor and the broad range of concentrations it can detect lies in the use of magnetism.
How magnetic nanotags reveal the quarry
The basic mechanism of detection employed in the magneto-nano sensors is to capture antigens - deleterious compounds produced and shed by the cancer cells - using antibodies that naturally tend to bond with the antigens. The antibodies, dubbed "capture antibodies," are applied to a sensor, so that when the matrix of interest is placed onto the sensor chip, the appropriate antigens bind.
While the antigens are held fast, another dollop of the antibodies is applied. These antibodies are attracted to the antigens held on the sensors, and in bonding with them effectively seal the antigens inside an antibody sandwich. The researchers then apply a wash containing magnetic nanoparticle tags that have been tailored to fit specific antibodies. The magnetic nanotags attach themselves to the outer antibody on the sandwich, where they alter the ambient magnetic field in a small but distinct and detectable way that is sensed by the detector.
The protein-detection assays that are currently in use rely on a variety of mechanisms, such as measuring electrical charge, fluorescent signals or pH, all of which are prone to interference from the biological matrix in which the desired proteins reside. While a particular assay may be fine for assessing a protein's concentration in urine, for example, it may perform poorly when applied to a blood sample, as differences in the composition of the matrix affect properties such as pH or electrical charge.
"Our sensors are shown to be rather insensitive to matrix, so that is another key element from a scientific point of view," said Wang. As an example, he said, "We know that in saliva and blood, they have totally different pH values and different chemistry, but they are all nonmagnetic. Magnetically they are just like air. So it does not interfere with our mechanism [of detection]."
Most of the assays currently in use are only able to detect proteins over a narrow range of concentrations before interference of some kind degrades the sensitivity of the assay. That can require a series of assays to be performed on a sample diluted to different strengths, in order to assemble a complete picture of a protein's concentration in the matrix. But again, by using magnetic detection, Wang and his colleagues are able to sidestep such signal degradation.
"With the high sensitivity and the broad range we can look at a big panel of proteins over a wide range of concentrations, and with the matrix insensitivity, we can look at them in different fluids," said Richard Gaster, MD/PhD candidate in bioengineering and medicine, and first author on the Nature Medicine paper. "We don't have to tailor where we are looking; we can look at everything simultaneously." That produces savings in time, which, once the sensor comes into commercial use, will also translate into monetary savings.
Another virtue of the technology, Wang said, is that it uses existing technology already in use in the data storage and semiconductor industries and because of that, he added, "It can be made relatively cheaply."
"It is the same sensor you are using in a hard disk drive to read a hard disk back," he said. "Very similar to that."
One of the next steps in the research, Wang said, is to test the magneto-nano sensors on human blood samples taken from a long-term study in which researchers drew blood samples from subjects prior to any of them being diagnosed with cancer. To this end, the Stanford team will be collaborating with the Fred Hutchison Cancer Research Center in Seattle and the Canary Foundation, a nonprofit organization that focuses on early diagnosis of cancer.
"We can actually use our technology to study all these samples and we may be able to tell a year before or half a year before or three months before the diagnosis," Wang said. "That work will be extremely interesting."
Funding for this research came from the National Cancer Institute, the National Science Foundation, the Defense Threat Reduction Agency, the Defense Advanced Research Projects Agency, the Department of Veterans Affairs, the Canary Foundation and the National Semiconductor Corporation.
Other authors of the paper in Nature Medicine are Drew Hall, graduate student in electrical engineering; Carsten Nielsen, visiting scholar in the molecular imaging program; Sebastian Osterfeld and Heng Yu, both researchers at MagArray Inc.; Kathleen Mach, life science research assistant in urology; Robert Wilson, senior research scientist in materials science and engineering; Boris Murmann, assistant professor in electrical engineering; and Joseph Liao, assistant professor of urology.
Stanford University has licensed part of the magnetic bioassay chip technology used in this research to MagArray Inc., an early stage startup company in Silicon Valley. Shan Wang, Sanjiv "Sam" Gambhir, Heng Yu and Sebastian Osterfeld hold financial interests in MagArray in the form of stock or stock options.
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Jay Rasulo's baseball-zipping photo of Olden Street, U.S.A. Filmporium
Enjoy a widespread afternoon in the Olden Street, U.S.A. Filmporium, where you can hope your kids are lulled to sleep by "Vengeful Willie" and other angels from the classic era of Disney animation. Turbulent animation fans may particularly enjoy seeing Underdog, Thumper, and all their favorite Disney queens on the Olden Street, U.S.A. Filmporium's typical screens.
Please don't try Zombie Mode
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Katt Williams Arrested for Fighting in a Club
Katt Williams' short fuse has gotten himself into trouble again, the umpteenth time this year alone. The comedian was arrested on Wednesday, November 14 in Oakland, California after getting into a scuffle at Kimball's Carnival. He was put into custody and has not been released, TMZ reported.
Earlier this month, Williams was sued by his former assistant Melissa Ishage after punching her in an altercation on October 6. The father of nine reportedly hit her in the head and knocked her to the ground, leading the alleged victim to be taken to hospital to treat her injuries. Police was called to the scene when the incident happened, but no one was arrested.
Also in October, Williams was arrested for pulling out a gun on actor Faizon Love in Los Angeles over the money Williams owed Love. "Once the argument escalated, Katt went to his car to go get his gun to pull it out on me," Love said. "Fortunately, one of my homeboys who was there took the gun out of Katt's hands." Williams was released that same night and insisted that he did nothing wrong.
Williams also allegedly got into altercation with an audience at one of his Denver shows, threatening and spitting on the fan after he got booed on stage.
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Hi, new here! My name is Ashley and I am a SAHM to my 9 y/o son and 3 y/o daughter. We are planning to move to Katy August 1st and we'll be needing some new doctors.
Can anyone recommend a good family doctor (not a big practice please, just one Dr for the whole family) that is okay with not vaxxing and maybe knows a bit about lupus (just a general knowledge, I already have a great rheumatologist)?
Also, need a child & adult psychiatrist (hoping for one person to consolidate appts, but two different ones are fine) that is good with autistic children and bipolar adults.
Thanks in advance to anyone who can help me!!
Highly recommend Dr. Paul Dibble of Simple Traditions in Magnolia. He is a family doctor, okay with many alternative choices, makes home visits and after hour calls, etc. He has a website as well.
Shannon, Daughter of the King, Wife to Christopher, Blessed Mom of 3 Boys. Homeschool, SAHM, and midwife.
He seems very naturally-minded. I only know an adult who has visited, but I definitely would look into them for family care if I was in that area.
HeatherB ~ mama to 3 wonderful boys: 03/02; 09/04; 09/07 - and Eliana, 11/13/10!
Founder of Houston Birth Alternatives: Be Informed, Encouraged, Supported birth support group and aspiring midwife.
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end of the year teacher gift ideas- free printable gift card holders with cute sayings
Teacher Appreciation Gift with Free Printable Tag - A Teacher Takes a Hand, Opens a Mind and Touches a Heart
Teacher Appreciation Week Idea from pigskinsandpigtails.com
An App(le) for my teacher- Itunes - Printable {Teacher Appreciation Gift} Gift card holder
summer beach tote teacher gift
Musician appreciation idea
lantern teacher gift idea - such a cute teacher appreciation gift with printable tag.
Star Teacher/Star Wars shirt Teacher Appreciation Week gift!
Done for Teacher with Hollywood Theme in her classroom. (May 2011)
Would be super cute to do with pictures of each Guidance Counselor and AP and what/who they are responsible for!
Big Smiles from Kbear: Teacher Appreciation Week - Door #1 #nurse door #teacher appreciation week door
Gold Stars plastic table cover
Hollywood Theme Oscar Centerpieces - looked this up! Spray paint gold the ken barbies(dollar store) and hot glue them to a tuna can. Use them to hold flower ball! Could be used for "Oscars"
Fabulous centerpiece for an Oscar party. We love doing Hollywood themed parties. Here is an almost exact replica of our tables centerpieces from our party
This Little Teacher: STAAR Wars Bulletin Board Designs - Texas Standardized Testing
Creative Mommas: March PTO Teacher Spotlight Bulletin Board
Free Printables for Mom's Movie Night #cmyk
Salt and Pepper Moms: Donut Teacher Appreciation Printables
Star Wars - May the 4th Be With You - Gift - Teacher Appreciation
Teacher Appreciation- Star Wars! ~ The Red Balloon
Teacher Appreciation- Star Wars!
It's teachers appreciation week! #thankateacher #education
Photo 26 of 41: Star Wars / Birthday "Star Wars Birthday" | Catch My Party
Teacher Appreciation- Star Wars!


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Town Square
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AROUND TOWNIf it's Tuesday, it must be another Oak Grove debate
Over the last couple of years, a regular contingent of opponents to the proposed 51-home development above Kottinger Ranch...Original post made on Apr. 23, 2010
Last comment by justwondering, on Apr 26, 2010 at 11:46 am | 14 comments | 1275 Views
Okay! A lot of noise and a lot of chatter on the forum. But, today I drove through the vineyards with the sun beating down...Original post made by reasonable center on Jun. 26, 2010
There are no comments yet. 1275 Views
AROUND TOWNAny recommendation on a vendor/contractor for tankless water heater?
Hi - I am planning on installing a tankless water heater and am wondering if anyone here can recommend a reliable vendor/contractor...Original post made by Jerry on Nov. 19, 2010
Last comment by Tango, on Nov 19, 2010 at 9:29 am | 1 comment | 1275 Views
AROUND TOWN"Only" 17 cents a day
I realize that Pleasanton Weekly doesn't seem to be able to cover costs with advertising, but 17 cents/day to subscribe seems...Original post made by seniorgrump on Jun. 21, 2011
Last comment by ???, on Jun 23, 2011 at 10:00 am | 6 comments | 1275 Views
AROUND TOWNTeacher's Retirement Fund Wants You - The Taxpayers!
Original post made by Arnold on Dec. 30, 2011
Last comment by to: stacey, on Jan 2, 2012 at 11:10 am | 2 comments | 1275 Views
COMMENTS ON STORIESSend us your Santa photos
Have your kiddies visited Santa yet? If you took a photo you'd like to share, send it to us at firstname.lastname@example.com....Original post made on Dec. 6, 2011
Last comment by santa Claus, on Dec 6, 2011 at 2:42 pm | 4 comments | 1275 Views
COMMENTS ON STORIESChubb golf tourney scores $6,000 for REACH
Tanner Insurance Services representative Ron Hernbroth and Chubb Group representative Kurt Stemmler present a $6,000 check...Original post made on Dec. 26, 2013
Last comment by Zoe, on Dec 26, 2013 at 10:15 am | 1 comment | 1275 Views
SCHOOLS & KIDSPower of Green and Red Language
This free communications class meets from 6:30 to 8:30 p.m. Feb. 25 at Amador Valley High School, 1155 Santa Rita Road. It...Original post made on Feb. 25, 2010
Last comment by TI, on Feb 25, 2010 at 11:47 am | 3 comments | 1274 Views
STATE, NATIONAL, INTERNATIONALOakland council to vote tonight on bid to oppose BART airport connector
The Oakland City Council will vote tonight on a resolution expressing opposition to BART's connector from the Coliseum station...Original post made on Oct. 6, 2009
Last comment by Safety First, on Oct 7, 2009 at 6:36 pm | 9 comments | 1274 Views
AROUND TOWNGiving Us the Finger
While driving from Livermore to Pleasanton on 580, I noticed that Dublin has again given us the Finger. I am referring to...Original post made by tango on May. 17, 2011
Last comment by LoandBehold, on May 28, 2011 at 1:21 pm | 3 comments | 1274 Views
The election is over folks! Time for everyone - the Yes and the No people to start working together. Rehashing the voting...Original post made by It\'s Over on Jun. 3, 2009
Last comment by Billie, on Jun 3, 2009 at 12:07 pm | 13 comments | 1273 Views
SCHOOLS & KIDSCamps June 14-18th
There are very few camps that begin this week in the Bay Area. Camp personnel of camps that do offer service this week tell...Original post made by Dana on Jun. 15, 2010
There are no comments yet. 1273 Views
SCHOOLS & KIDSWhy does Superintendent Parvin Fear Transparency?
Why does Superintendent Parvin fear transparency? At last night's board meeting the Registrar for Foot Hill's High School...Original post made by S.M on Apr. 9, 2014
Last comment by S.M., on Apr 9, 2014 at 10:23 pm | 10 comments | 1273 Views
SCHOOLS & KIDSShocking language within Union reps and teachers shows double standard
I just read the documents that included sworn depositions from high-ranking union officers and others involved in the Vranesh...Original post made by Not PC on Sep. 23, 2015
Last comment by CP for short, on Sep 24, 2015 at 1:49 pm | 10 comments | 1273 Views
AROUND TOWNWell, over 100 million retarded, head in the sand liberal Dems
As of May 30, 2009, the US Population was estimated at 304,059,724 persons. Well, over 100 million retarded, head...Original post made by Anti Liberal on Oct. 21, 2009
Last comment by te, on Oct 22, 2009 at 4:26 pm | 6 comments | 1273 Views
AROUND TOWNHanukkah celebrations continue tonight, tomorrow as holiday observances end
In celebration of the closing days of Hanukkah, Chabad of the Tri-Valley will host an outdoor ice skating event from 6 to...Original post made on Dec. 18, 2009
Last comment by Paulette, on Jan 1, 2010 at 6:16 pm | 4 comments | 1273 Views
AROUND TOWNAttend a 'climate action plan' workshop tonight
Participants will explore the challenges facing Pleasanton in accommodating growth while reducing future greenhouse gas emissions....Original post made on Jan. 11, 2011
Last comment by Patriot, on Jan 12, 2011 at 10:04 am | 6 comments | 1273 Views
AROUND TOWNHelp Needed
THE FOOD PANTRY AT VALLEY BIBLE CHURCH NEEDS YOUR HELP The Food Pantry at Valley Bible Church first opened in March of...Original post made by Teresa on May. 11, 2011
Last comment by Alameda County Native, on May 19, 2011 at 12:06 pm | 3 comments | 1273 Views
AROUND TOWNWhale of a day
My kayaker husband Jeff and I heard some exciting news: The whales were feeding closer than usual to the shore in Santa Cruz,...Original post made on Nov. 19, 2011
Last comment by dave, on Nov 21, 2011 at 4:49 pm | 3 comments | 1273 Views
AROUND TOWNBronze-plated Stoneridge Drive extension
Tim Hunt's restricted article prompted me to a rest-of-the-story inquiry. If so many groups are willing to fund a Livermore...Original post made by Rest of the Story on Apr. 24, 2012
Last comment by Casanova_Frankenstein, on Apr 24, 2012 at 4:34 pm | 3 comments | 1273 Views
Changing my Registration for Bernie
By Roz Rogoff | 74 comments | 1,028 views
Conjecture Madness
By Tom Cushing | 4 comments | 469 views
Celebrating a long overdue groundbreaking
By Tim Hunt | 0 comments | 408 views
So You Are Planning on a Career in Law? Read on!
By Elizabeth LaScala | 2 comments | 325 views


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HP LASERJET 4050N Driver Utility 4.5
Get official HP LASERJET 4050N Drivers for Windows. HP LASERJET 4050N Driver Utility scans your PC for missing, corrupt and outdated drivers and automatically downloads and updates them to the...
Presentation Pointer 1.3.0
Grab your audience's attention and focus. Presentation Pointer provides visual cues about what and where you are doing things on your computer.
FileMaker Pro Updater X 6.0v4
FileMaker Pro Updater X 6.0v4 fixes 4-digit year dates and more. FileMaker Pro 6 is the leading workgroup database software for quickly creating and sharing solutions adapted to your business needs.
DTgrafic Bus Stop 2 3.1.0
Observe all the hectic goings-on at a normal bus stop: Willi S.drives past on his way to work just as he does every day. Therese Weinlaub is on the telephone again to an acquaintance. Grandad...
PDF Chart Creator Command Line Tool 1.2
The PDF Chart Creator Command Line Tool is a simple utility that can convert data into a variety of charts as a PDF document.
The chart creation process is initiated by calling...
XNetSwitcher 18.104.22.168
XNetSwitcher is a great and useful tool for laptop users. If you use laptop at different locations, such as client's site, home or office... and you had to change your network settings every time,...
Teroid ASP Data Export Control 1.0
Teroid ASP Data Export Control is an ASP .NET control allowing users to download data from an ADO .NET DataTable object in XML, CSV or HTML format. Teroid ASP Data Export Control is an ASP .NET...
Star Wars Jawas Theme v1.1
Star Wars Jawas Theme is a desktop theme based on the movie "Star Wars". It includes wallpaper, icons, animated cursors, and WAV sounds.
WhatFormat (16-bit) v1.4a
identifies the format of unknown file types. WhatFormat examines the first few bytes of a file to determine its format.
Video Comparer 1.02.004
Video Comparer is a Windows utility that quickly detects video duplicate files on your computer, and can easily delete them. It processes most codecs, finds cropped videos, rotated, noised, and...
UniQFace 184.108.40.206
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King's Bounty 1.0
This game is the precursor to the Heroes of Might and Magic series. As knight, paladin, barbarian or sorceress, amass an army of creatures to take on the local baddies and search for the Sceptre of...


text:
Trip Ideas Search Results
|Trip Idea Type
Picnic with the Best Views in Central Oregon
Whether it's a simple sandwich or salad or the fanciest charcuterie board, packing a picnic is a relatively easy way…
|Eat & Drink, Recreation, Wineries & Wine
|Oregon Story
Take a Ride Back in Time in Myrtle Creek
In Myrtle Creek, the town where Cycle Oregon's week-long ride starts and finishes, everyone knows your name. "…
|Cycling, Oregon Heritage, Recreation
|Oregon Story
A Walk on Eugene's Sweet Life Loop
My favorite way to explore a city is by walking. On foot, I can experience my environment in a way that I can't…
|Attractions, Eat & Drink
|Oregon Story
Table Rocks, Oregon's Islands in the Sky
If you're looking for an outdoor adventure that will take your breath away, journey to Southern Oregon where two…
|Attractions, Hiking, Mountains & Hills, Natural Wonders, Outdoors & Nature, Recreation
|Grant's Getaway
13 Reasons to Visit the Southern Oregon Coast
Welcome to Curry County, home to small salt-of-the-earth communities built to showcase and protect the natural…
|Attractions, Eat & Drink, Outdoors & Nature
|Oregon Story
Day Hike to Munra Point
Anyone who lives in or regularly visits Oregon and Washington should make a pilgrimage to theColumbia River Gorge…
|Attractions, Forests, Parks & Refuges, Hiking, Natural Wonders, Outdoors & Nature, Recreation
|Oregon Story
Astoria for Movie Lovers
C'mon, admit it: We all cried at the end of "Free Willy," whether we saw it back in the 1990s or more…
|Attractions, Movies and TV filmed in Oregon, Oregon Heritage
|Oregon Story
Hiker's Paradise in the Opal Creek Wilderness
Many have played for hours in the sun atThree Pools, the popular swimming hole in theOpal Creek Wilderness. But…
|Attractions, Bodies of Water, Lakes & Reservoirs, Natural Wonders, Outdoors & Nature
|Oregon Story
Rogue River Summers, According to a Rafting Guide
Ever since my first rainy Rogue River trip in 2010 with Northwest Rafting Company, I've been hooked. A rafting trip is…
|Attractions, Bodies of Water, Natural Wonders, Rafting, Recreation, Rivers
|Oregon Story
Road Trip: Oregon City
Oregon City just might be one of the prettiest little cities within a stone's throw of Portland. Just 13 miles south…
|Attractions, Beer & Breweries, Bodies of Water, Eat & Drink, Kayaking, Museums & Interpretive Centers, Natural Wonders, Oregon Heritage, Outdoors & Nature, Recreation, Rivers, Tour Companies & Guides
|Oregon Story


text:
Writers Profile
Screen Name: Jools M
Jools M has published 15 items on The Spoof.
Check out Jools M 's:
Latest Spoof News Story: Thursday 19th March 2009
Spoofing since: Thursday 9th November 2006
Location: Worcestershire UK
Profile: Life is far to short to shell peas
Jools M hasn't written anything in a while, so his/her news feed is seriously out of date!
If you want the latest up-to-the-minute spoof news, check out all our rss feeds.
While you're here, why not check our other Top Writers?
And if you've still got time on your hands, consider joining us as a writer, and make up your very own news stories!
Barack Obama To Be Crowned EmperorObama is to be crowned First Emperor of the New World Order at a special ceremony conducted by Pope Francis at the Vatican Basilica this August 4th, his birthday.
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Brunswick (Maryland)
From Wikitravel
Earth : North America : United States of America : Mid-Atlantic : Maryland : Capital Region : Frederick County : Brunswick
Brunswick [1] is a small town in Frederick County, Maryland, on the Potomac River. Once a company town for the B&O Railroad, now a sleepy bedroom community, it can make for a good access point for activities along the Potomac.
Get in[edit]
By train[edit]
Brunswick is, appropriately enough, on the Brunswick line of the MARC commuter rail line, which runs from Washington, D.C. to Martinsburg, West Virginia.
Amtrak's Capitol Limited runs through Brunswick, but the nearest stop is Harpers Ferry, West Virginia, 8 miles to the west.
Get around[edit]
Have a car or plan to be stuck.
No good nightlife or drinking spots are in Brunswick other than Beans, listed above. The nearest full service bars are to be found in Frederick. But coming soon:
Get out[edit]


text:
Turns out the Game of Thrones intro also works with slime mouldThursday, May 26th, 2016 12:04 pm
Everyone loves the Game of Thrones intro. It's mesmerising. But did you know it also works if you replace all the dainty little buildings with… mould? Someone on YouTube going by the name of Transcend Rules has set a gorgeously-shot video of slime mould to the themetune we all know and love, and it's hypnotic. […]
The post Turns out the Game of Thrones intro also works with slime mould appeared first on Gadgette.
The cat-flap as a psychoanalytic metaphorThursday, May 26th, 2016 11:30 am
Stefano Bolognini, who is president of the International Psychoanalytical Association explores the usefulness of the cat-flap as a psychoanalytic metaphor in his book 'Secret Passages : The Theory and Technique of Interpsychic Relations' (2011 – Routledge).
The book is reviewed by Professor Cordelia Schmidt Hellerau in an essay entitled 'SECRET PASSAGES:SOPHISTICATING THE CAT-FLAP' (in: Psychoanalytic Quarterly, Volume LXXXI, Issue 2, pages 443–455, April 2012.) Bolognini's work, explains the professor :
"[…] provide[s] us with the sense of getting to know a seasoned psychoanalyst who loves his work and generously shares with us not only the highlights of successful interpretations, but also the at times stumbling, tentative, or awkwardly searching steps that will help both, analyst and patient, find their way to the cat-flap."
The 'cat-flap' metaphor in this context is illustrated by passages from the book.
"Perhaps, without our knowing, there was a draft, a door left ajar between our mental apparatuses, or a small opening, almost invisible, like in the great wooden doors of Italian houses in medieval times, at the bottom of which was a swinging flap (a 'cat-flap') through which the house cat could come and go unheeded, unseen, and without disturbing its owners, intent on other pursuits. [p. 66]
[The cat-flap] . . . is a good symbol for a structural (it is part of the door) and functional (it was specifically designed so that the cat can carry out its function of catching mice inside and outside the house) device that is not only intrapsychic but also interpsychic. The cat-flap is quite distinct from the door, which allows the passage of people, and from incidental cracks, which allow the passage of mice, clandestine, parasitical guest that harm the community / interpsychic-relational apparatus. [p. 67]"
Bonus Assignment [optional]:
Discuss the appropriateness (or otherwise) of 'the cat-flap' as a Freudian metaphor, bearing in mind that prof. Bolognini's book was originally published in Italy, where 'gattaiola' (cat-flap) may not have the same euphemistic connotations as it does in English (clues may be found in the following) :
Resources (psychoanalytic journals):
• Psychoanal. Dialogues
• Int. J. Psycho-Anal.
• J. Anal. Psychol.
• Contemp. Psychoanal.
• J. Am. Psychoanal. Assoc.
• J. Am. Acad. Psychoanal.
• Int. Rev. Psychoanal.
• Psychoanal. Inq.
Note: The photo shows the Staywell 300 4 Way Locking Cat Flap available from Catflaps.co.uk (£15.16 inc. taxes).
US strategic nuclear systems still use 8-inch floppiesThursday, May 26th, 2016 11:50 am
Some of the most critical business systems run by US government agencies are older than many of the IT people who support them, written in mainframe assembler code or COBOL. That might not shock or surprise anyone who works in mainframe-centric industries like insurance and finance, where the time-tested reliability of some systems has granted them lives that reach back to the Johnson administration. But a new GAO report has called out some of these systems as being so archaic that they're consuming increasingly larger portions of agencies' IT budgets just for operation and maintenance. As the breach at the Office of Personnel Management demonstrated, old systems are also a security risk—particularly when they've been "updated" with now-unsupported versions of Windows Server and Internet and database components that were end-of-life'd by their creators years ago.
To drive those points home, the report—written by David A. Powner, GAO's Director for Information Technology Management Issues—called out specific legacy systems from multiple agencies that are particularly obsolete, reliant on older programming languages and older computing technology that are no longer supported. To help members of Congress too young to remember them, the report also included an infographic (as show above) to explain what an 8-inch floppy disk was.
Of the top ten oldest systems cited by GAO, six are over 50 years old—and five of the ten oldest systems, all dating from before the 1980s, are not slated to be replaced anytime soon. And it should come as no surprise that the two oldest systems in government are at the Internal Revenue Service, and both will remain in place for some time.
Mobile data's hunger for spectrum signed off by EU ministersThursday, May 26th, 2016 11:35 am
Europe's telecommunications ministers agreed on Thursday that the 700MHz band should be handed over to mobile broadband services by 2020 to allow them to push 4G, and more easily transition to the next generation 5G tech.
Under the proposed deal, approved by the telecoms council, EU countries must set out national strategies to reassign the 700MHz band (694-790MHz) to wireless broadband by June 2018, with the handover expected to be completed by four years from now.
In exceptional circumstances—such as unresolved harmful interference, or cross-border coordination issues—an extension of two years may be considered.
Astronauts open expandable space roomThursday, May 26th, 2016 11:11 am
Navy investigates 'lost submarine find'Thursday, May 26th, 2016 09:23 am
SleepyThursday, May 26th, 2016 12:55 pm
I was so good at keeping on top of dishes and tidying and stuff while they were here -- partly to keep them fro grumbling or doing them for me, partly as an excuse to keep busy enough not to have time to think -- I hoped that I might be able to keep it up, as it's easier to keep things clean than get them clean... ha.
I kind of wish I'd been able to keep up the levels of willpower in getting chores done that I had for the previous couple of weeks. But then I think about how badly it exhausted me to push myself to do so many things when I didn't think it'd be good for me, and how I knew I could keep that up only because it was for a limited time. It's not very kind to myself to wish that I lived like that all the time.
This hacked IKEA bookshelf plays TetrisThursday, May 26th, 2016 11:48 am
Here at Gadgette we love hacking and DIY projects as much as we love games, so it's perfect when the two come together. Last year Øyvind Berntsen proposed to his girlfriend by transforming their giant IKEA bookshelf into a game of Snake that finished with a giant ring. It was a cute viral video and I loved the idea […]
The post This hacked IKEA bookshelf plays Tetris appeared first on Gadgette.
Getting babies to stop crying and not die may have made humans smarterThursday, May 26th, 2016 11:20 am
With sleepless nights and puzzling crying spells, caring for a newborn may seem like a mind numbing endeavor. But the mental abilities needed to keep a helpless, fussy infant alive may actually be the source of our smarts.
Humans' extraordinary intellectual abilities may have arisen, in part, in an evolutionary feedback loop involving the care of helpless infants, researchers hypothesize in a study published in the Proceedings of the National Academy of Sciences. In the loop, big-headed babies are born relatively early in their development to ensure that they fit through the human vaginal canal. The underdeveloped newborns then rely heavily on the savviness of their parents for survival. Through generations, this selects for brainy parents, which pushes kids to have ever fatter noggins and, thus, earlier births.
"Human infants are born far more immature than the infants of other species," study author Celeste Kidd, a brain and cognitive science researcher at the University of Rochester, said. "For example, giraffe calves are able to stand-up, walk around, and even flee from predators within hours of their births. By comparison, human infants cannot even support their own heads."
Online ads are much naughtier than TV commercials, says watchdogThursday, May 26th, 2016 10:55 am
Web-based adverts sparked a big caseload of complaints in the past year with offerings for computer games, gambling, films, and DVDs—but surprisingly not broadband services—topping the UK ad regulator's moanfest list.
The Advertising Standards Authority said on Thursday that 4,584 ads were changed or withdrawn, following investigations into gripes about commercials across different mediums.
"While this figure has risen 32 percent since 2014, it still represents only a small proportion of the overall advertising landscape," the ASA said in its annual report.
HP's new Omen gaming laptops are fast, affordable, and surprisingly professionalThursday, May 26th, 2016 10:34 am
Much of the time at Ars we look at laptops that tend towards the thinner and lighter end of the spectrum. These are great for portability, but they all tend to give up a little, and sometimes a lot, when it comes to raw performance. HP's new Omen gaming laptops tilt things much further in the performance direction, and they manage to do so while still offering decent portability, competitive pricing, and, refreshingly, looks that aren't too gamery: turn off the red backlit keyboards, and they'll not look too out of place as capable workhorses too.
Going on sale July 1 in the UK and starting at £699, you can get the 15.6 inch 1920×1080 IPS screened 4.6lb (2.1kg) laptop with a quad-core Skylake Core i7-6700HQ, 8GB RAM, Nvidia GTX 950M GPU with 2GB dedicated memory, and a 1TB 7200rpm hard disk.
Spend a bit more and you can go up to a GTX 960M with 4GB dedicated memory, 16GB RAM, and add a 128GB SSD alongside the spinning disk. All the systems have 2×2 802.11ac Wi-Fi, 2 USB 3 ports, wired gigabit Ethernet, and a full-size HDMI output. The keyboards make full use of the 15 inch form factor, sporting a full number pad alongside the keys—something that we know many of you look for in these larger laptops.
Day 5625: Messages from Cheadle #1 - the NHSThursday, May 26th, 2016 11:26 am
We are trying a new experiment in VIDEO BLOGGING.
Daddy Richard will be doing some news'n'views from his old home town, and for the start he has brought Daddy Alex along to go back to the very beginning, the place where he was born.
More to follow, you lucky people!
Women in tech history: Hedy Lamarr – Hitler, Hollywood, and Wi-FiThursday, May 26th, 2016 10:30 am
This is the sixth article in a series about amazing women in tech history. Previous entries have featured Margaret Hamilton, Grace Hopper, the ENIAC programmers, Katherine Johnson, and the women of Bletchley Park. Today's entry is a bit of an anomaly. We've covered some inspiring women in this series but most of them aren't well-known to the general public. This […]
The post Women in tech history: Hedy Lamarr – Hitler, Hollywood, and Wi-Fi appeared first on Gadgette.
Interesting Links for 26-05-2016Thursday, May 26th, 2016 12:00 pm
- Is Facebook eavesdropping on your phone conversations?
- (tags: facebook privacy advertising )
- For the first time since the 1880s, more young Americans are living with their parents than with a romantic partner.
- (tags: usa housing money inequality )
- Civilization VI hands on preview (looks very good)
- (tags: games )
- Foxconn replaces 60,000 factory workers with robots
- (tags: robots manufacturing china jobs )
- On School Rolls, Gaelic and Overcrowding in Edinburgh
- (tags: edinburgh language scotland school )
- When LinkedIn emails all of your friends to call you a white supremacist.
- (tags: nazis racism internet OhForFucksSake names viaTheWeaselKing )
- What's happening with Scotland's named person policy? And what's going to happen to it?
- (tags: scotland children snp politics )
- A Silicon Valley billionaire is reportedly funding the legal war to end Gawker
- (tags: media USA wtf )
- How to deal with token characters
- (tags: writing race gender )
- In which the BBC and Sky argue over who Captain America's boyfriend should be
- (tags: sky bbc slash relationships marvel )
- Unflattering Animal Pictures
- (tags: animals photos funny )
- Three UK announces next steps in plans to improve mobile advertising
- (tags: advertising phones )
- Most British people say they will never forgive Tony Blair
- (tags: tonyblair politics iraq war middle_east labour uk )
- Anti-cancer HPV jab piloted in gay men
- (tags: lgbt cancer vaccination )
Legal Highs not produced by the Government's friends now bannedThursday, May 26th, 2016 10:42 am
New image added to Pinterest board Giovanni Boldini on May 26, 2016 at 09:58AMThursday, May 26th, 2016 10:28 am
I added a new image to my Pinterest board Giovanni Boldini
New image added to Pinterest board Giovanni Boldini on May 26, 2016 at 09:57AMThursday, May 26th, 2016 10:28 am
I added a new image to my Pinterest board Giovanni Boldini
VIDEO: New room inflated on side of ISSThursday, May 26th, 2016 10:36 am
How the EU debate turned into CSI BrusselsThursday, May 26th, 2016 09:29 am
This article was first published in The Guardian
"Usually I'd say 'What do the Tories want?' and do the opposite. But you can't even do that." This complaint from an undecided voter in one of my recent focus groups sums up the frustration many people feel about the EU referendum campaign. For all that people grumble about partisan politics, the parties' competing brands – their familiar character, principles, policies, personalities and history, in or out of office – help voters make decisions.
Without party brands to guide them, many voters feel at sea. The Conservatives are split on EU membership, and Labour has barely shown up to the debate – even those who have registered Jeremy Corbyn's backing for remain doubt he really means it.
To many, the decision feels more important, but much more difficult, than a general election vote. Choosing a party that looks more or less like it knows what it is doing is much easier, it turns out, than reaching a verdict by weighing the evidence.
If an election is a battle of the brands, then the referendum campaign is CSI Brussels. My latest poll helps explain how the jury – the voters – are approaching the case.
With which side does the burden of proof lie? Most say the two campaigns have an equal responsibility, but slightly more say the onus is on the leave campaign than on remain. Though undecided voters accept that the EU may change in unpalatable ways, it still feels like the devil they know compared to the prospect of life outside.
A majority of voters say they will decide on the balance of probabilities, but those currently leaning towards leave are more likely than remainers to say they will need to be convinced beyond reasonable doubt. Most also expect their instincts to play a bigger part than factual information in their decision. This is truest for older voters – those aged 18 to 24 expect to decide on the basis of facts by a margin of two to one. This surely reflects the optimism of youth, since the lack of reliable facts is most people's biggest single gripe about the campaign.
Their demand cannot be met, of course, since there is no data about the future, and even statements about the present – the number of jobs that depend on membership of the single market, for example, or the true figure for Britain's contribution to the EU budget – are heavily contested. The more lurid warnings from each side are dismissed as scaremongering. But so, increasingly, are even the most soberly delivered forecasts about the potential downsides of staying or going.
Moreover, the motives of every witness are distrusted: President Obama acts in America's interests, not ours; business people want what's best for their companies, not the country; bodies such as the IMF will seek to protect the rest of Europe more than the UK.
Mark Carney, the Bank of England governor, is the closest we have seen to an impartial expert in the eyes of the electorate, but some question whether even he would say anything that might upset the government.
So the voters are left to piece together what truths they can from each side's case. The leave campaign's main theme – taking back control – is potent. I found more than six in 10 agreeing that "we must have more control over our own affairs even if that means missing out on some of the benefits of co-operating with other countries". Just over one-third say that the benefits of EU membership will always outweigh the cost in terms of giving up some control over our own affairs; or that safeguards are in place to ensure too much control is not given away in the future.
The rest think the benefits used to outweigh the loss of control, but no longer, and fear too much control will be given away if we stay – or that the loss of control was never justified by the benefits of membership.
The case for remain, meanwhile, relies on risk. In my poll participants placed themselves on a scale, where zero meant they would definitely vote to remain and 100 meant they would definitely vote to leave. Over half put themselves above 50, meaning they were inclined towards leaving.
Even so, a small majority thought leaving the EU was a bigger risk than remaining. Despite the leave campaign's warnings of what the union could become, most thought "the fact that we don't know for sure what life outside the EU would be like" sounded like a bigger risk than "the fact that we don't know for sure how the EU will develop or change if the UK remains a member" – especially for women, younger people and, crucially, undecided voters.
Overall, slightly more said that "the risks to the UK if we make the wrong decision" would play the bigger part in their final judgment than "the importance of controlling our own affairs".
The verdict, then, hangs in the balance. But that is not the only thing. On one question my poll respondents were precisely divided. Exactly half thought the decision we make in the referendum "might make us a bit better or worse off as a country, but there probably isn't much in it either way"; the other half thought it "could have disastrous consequences for us as a country if we get it wrong".
There are four more weeks of evidence until the jury retires. As of now, not only can we not decide what to do, we can't even decide how much it matters.
Irish watchdog refers Facebook privacy case to Europe's top courtThursday, May 26th, 2016 09:25 am
Facebook's vast data stockpiling business has been referred to the European Union's top court by Ireland's information watchdog—thereby intensifying the debate around a proposed EU-US data transfer pact dubbed Privacy Shield.
Ars understands that papers will be lodged in the courts six days from now.
Facebook—which has its European headquarters in Ireland, a country known for its lax approach to data laws—could face questions from the CJEU about the validity of the contractual clauses it uses to transfer data outside of the 28-member-state bloc.
The Blood is the Life for 26-05-2016Thursday, May 26th, 2016 11:00 am
- Smug Roxy is smug #dogs #dogsofinstagram #sheltie #rescuedog #adoptdontshop
- I've got a northern accent but I'm not working-class. So what am I?
- Day 25 of @mjrutell's #pfsixwordchallenge - prompt: unlikely hero #ink #inkyfingers…
- Day 25 of onicahanby's #quotedmay2016 #challenge - prompt: key #ink #inkyfingers #fountainpen…
- EU referendum: White 'thug' poster aimed at BAME voters
- Nigel Farage says Operation Black Vote are trying to divide society with this poster. I suppose he'd know...
- politicalbetting.com » Blog Archive » How old men being available on Friday nights to do online polls might be skewing results
- People with strong political opinions more likely to jump at YouGov surveys shocker
- This is horrific
- RT @feministculture: Trans woman dies of gunshot wounds while doctors decide if she should be allowed in women's ward
Latest immigration figures give Nigel Farage 'best erection in years'Thursday, May 26th, 2016 09:02 am
Judging by his betting price collapse Boris's back LEAVE decision hasn't been good for his career amThursday, May 26th, 2016 09:04 am
Boris no longer favourite to be next CON leader. Osborne moves back into the top slot pic.twitter.com/cjP7op8adw
— Mike Smithson (@MSmithsonPB) May 26, 2016
If the vote is REMAIN the ex-mayor could be the scapegoat
Yesterday the Daily Mail's renowned columnist, Katie Hopkins had a big go at the ex-Mayor under the heading "I thought Boris was going to save Britain from the EU, instead he has turned out to be a big fat fraud."
In it she registered in her own inimitable style her disappointment at Johnson's performance in the three months since he made his announcement on February 21st. She concludes:
"If the Brexit side does lose, much of the blame will lie with Boris – who will have no compunction about scampering back aboard the government bus if he gets half a chance.
So let's hope Cameron doesn't forgive him. Because I won't."
Whatever happens on June 23rd there will be a huge fall-out across the political scene but most of all within the Conservative party. A LEAVE win or a very narrow REMAIN victory look set to be the peg for Cameron's exit and we will move into contest.
To become Tory leader Boris has first to surmount the parliamentary test and come in the top two of exhaustive ballots of party MPs. Assuming Osborne or an Osbo-backed contender gets one of those slots the big fight looks set to be amongst the Brexiters. That could be down to "Boris" or the "Stop Boris" choice. So the ex-Mayor's future could be in the hands of his fellow BREXIT Tory MPs and their perception of his contribution to the outcome will be crucial.
It has been said ever since his decision on February to back leave that he was doing this solely for career purposes. Maybe that will turn out to have been a huge gamble that failed.
Chart showing 60 day trend on Betfair next CON leader market pic.twitter.com/xpSRXIx101
— Mike Smithson (@MSmithsonPB) May 26, 2016


text:
Most Recent Articles In Fashion Scoops
Latest Fashion Scoops Articles
- Delvaux Lunch at Barneys Beverly Hills Draws Ann Dexter-Jones and Offspring
- Townsend Bell to Drive Robert Graham Car in Indy 500
- British Fashion Council Announces Twelve Fashion Trust Recipients
More Articles By
FRENCH FLAVOR: Y-3 is moving its runway show to Paris from New York next season. The co-branded fashion line by Yohji Yamamoto and Adidas, which celebrated its 10th anniversary this year, will show its fall collections for men and women in Paris on Jan. 19, during men's fashion week. The location has yet to be announced.
This story first appeared in the December 6, 2013 issue of WWD. Subscribe Today.


text:
Vencie Leonard Glenn
Position: DB
Height: 6-0 Weight: 205 lbs.
Born: October 26, 1964 in Grambling, LA
High School: John F. Kennedy
College: Indiana St. (school history)
Drafted by the New England Patriots in the 2nd round (54th overall) of the 1986 NFL Draft.
Weighted Career AV (100-95-...): 51 (1401st overall since 1950)
Output includes all games from 1920 to 2015.


text:
Mashup: Geowalk
A useful worldwide travel guide in German and English. With embedded data from Wikipedia, Flickr and Google News. Double-click anywhere on the map for details on that location.
Mashups using the same API (3056)
The portal of the Inter-University Campus of Excelence of Murcia. The CMS made for this website integrate publication of videos, news, events, maps locations, audio files and images publishing...
Makes it easy to post your current location to Twitter so that it's picked up by Twittervision. Zero signup using OpenID.
Reviewing.net utilizes rating APIs to provide users with a grouping of individual ratings from multiple sites. Specifically, it allows users to search for products, movies, and business ratings. When...
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Shaken, Not Stirred: The Earthquake Data Portal API
The Earthquake Data Portal API provides event information in both SOAP and REST-style services. For SOAP, the information is provided in QuakeML format. For REST, information is in either QuakeML or JSON formats. Users can do Event Searches, review Latest Events and look at Event Details. Data on seismic waveforms and their velocity are also provided, including the ability to predict arrival times and locations after they have been detected. The API will identify the data providers within the Seismolink network.
Placester Launches New Real Estate Platform for Developers
Placester, a real estate technology and marketing company, has announced the launch of the Placester Developer Platform for Real Estate, a brand new platform that allows developers to create dynamic real estate and applications. The platform consists of four components; a RESTful API, an IDX plugin for WordPress, a theme-framework and a theme gallery.
Why Aren't There More Transit APIs?
Google now has over 400 cities included in its transit service. That means each of those organization provides a feed so that the search giant can give accurate routing, schedules and fares. So, why isn't it easier for the average developer to access this data?
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Bing News Search
|The Bing News Search API returns a list of world news from a search query which can be filtered by local news, topic, and searchable metadata. Results include information such as authoritative images...
Travelbriefing.org public
|The Travelbriefing.org Public API is a database-as-a-service platform that provides access to country-specific information about travel regulations and prevailing environmental conditions. Users...
|ipapi.co API is a location finder solution that summarizes the geographic parameters of mapped locations. The API sends HTTP requests and returns responses in JSON format. It also provides code...
Pincodes of India
|The Pincodes of India API is a solution that uses either postal or pin codes to identify the exact locations of India's expansive network of post offices. The API transmits requests and responses in...
|The AddTransit API enables easy integration between the AddTransit GTFS, GTFS-Realtime and Ticketing functionality and other systems. The AddTransit API is currently in beta. Contact the provider for...