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- [Show abstract] [Hide abstract] ABSTRACT: Only few large-scale epidemiological studies have examined the prevalence of Helicobacter pylori (H. pylori) infection in Japan. The aim of the present study was to estimate the prevalence and incidence of H. pylori infection in Japan in terms of gender, age and region. Serum anti-H. pylori antibody testing was included in workers' annual health checks conducted by T-company's health insurance association in 2008. The testing was continued for the next 5 years in 35-year-old subjects. The total number of subjects was 21 144 (18 398 males and 2746 females). Stratified for age, there were 5016 subjects (male : female = 4219:797) in their 30s, 8748 (7770:978) in their 40s, 5589 (4807:782) in their 50s, and 1769 (1584:185) in their 60s. The H. pylori seropositive rate (male : female) was 27.5% (27.5:27.7) overall, 18.0% (18.3:16.1) in subjects in their 30s, 22.9% (22.7:24.7) in those in their 40s, 37.4% (37.2:38.2) in those in their 50s, and 46.1% (45.7:49.2) in those in their 60s. The prevalence of H. pylori seropositivity increased as age increased; however, no significant differences were seen between genders or among regions (χ(2) test). The numbers of 35-year-old subjects from 2008 to 2012 were 1072, 1107, 941, 1065, and 940, respectively. The corresponding H. pylori seropositive rates were 17.4, 17.4, 14.3, 13.3, and 14.0%, respectively. The Japanese H. pylori infection rate had already declined to 27.5% in 2008, with subjects in the 35-70 age range. The prevalence of H. pylori infection is also decreasing gradually from 2008 to 2012. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Article: Changes in the first line Helicobacter pylori eradication rates using the triple therapy-a multicenter study in the Tokyo metropolitan area (Tokyo Helicobacter pylori study group)[Show abstract] [Hide abstract] ABSTRACT: Helicobacter pylori (H. pylori) infection is a strong risk factor for the development of gastric cancer. In 2013, the Japanese government approved H. pylori eradication therapy in patients with chronic gastritis as well as peptic ulcer. However, the continuing decline in eradication rates for first-line H. pylori eradication therapies is an urgent problem. In this study, we investigated changes in the first-line eradication rate from 2001 to 2010. Eradication rates for 7-day triple therapy [proton pump inhibitor (rabeprazole 20 mg, lansoprazole 60 mg, or omeprazole 40 mg) + amoxicillin 1500 mg + clarithromycin (CAM) 400 or 800 mg, daily] were collated from 14 hospitals in the Tokyo metropolitan area. The urea breath test was used for the evaluation of eradication. The cut-off value was less than 2.5%. The yearly eradication rates (intention to treat/per protocol) were 78.5/79.5% (2001, n = 242), 71.2%/72.9% (2002, n = 208), 67.8%/70.5% (2003, n = 183), 75.6%/84.6% (2004, n = 131), 56.4%/70.5% (2005, n = 114), 70.5%/75.8% (2006, n = 271), 67.4%/82.0% (2007,n = 135), 64.0%/76.3% (2008, n = 261), 60.5%/74.3% (2009, n = 329), and 66.5%/78.8% (2010, n = 370), respectively. Examination of eradication rates according to CAM dosage revealed an eradication rate of 65.6% (383/584) for CAM 400 mg daily, and 68.5% (1124/1642) for CAM 800 mg daily, with no significant difference seen between dosages. In recent years, eradication rates for first-line triple therapy have obviously decreased, but no noticeable decrease has occurred after 2001. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Article: Trends of Second-Line Eradication Therapy for Helicobacter pylori in Japan: A Multicenter Study in the Tokyo Metropolitan Area[Show abstract] [Hide abstract] ABSTRACT: In Japan, the eradication rate of first-line therapy for Helicobacter pylori (H. pylori) with a proton pump inhibitor (PPI), amoxicillin (AMPC) and clarithromycin (CAM) has been decreasing because of a high prevalence of CAM resistance. A possible decrease of the eradication rate for second-line therapy with a PPI, AMPC and metronidazole (MNZ) is of concern. The aim of this study is to assess the trends in second-line eradication therapy for H. pylori in Japan. We accumulated data retrospectively on patients administered second-line eradication therapy for Helicobacter pylori with a PPI, AMPC, and MNZ for 1 week after failure of first-line eradication therapy with a PPI, AMPC and CAM at 15 facilities in the Tokyo metropolitan area in Japan from 2007 to 2011. Trends for second-line eradication rates in modified intention-to-treat (ITT) analyses were investigated. Second-line eradication rates were categorized by three PPIs (rabeprazole (RPZ), lansoprazole (LPZ) or omeprazole (OMZ)) and evaluated. We accumulated data on 1373 patients. The overall second-line eradication rate was 92.4%. Second-line eradication rates in 2007, 2008, 2009, 2010 and 2011 were 97.7, 90.6, 94.5, 91.8 and 91.8%, respectively, with no significant trends revealed. Second-line eradication rates categorized by three PPIs for the entire 5-year period were 91.6, 93.4 and 92.4% (RPZ, LPZ and OPZ, respectively) with no significant differences among the three PPIs. From 2007 to 2011, there were no significant trends in the second-line eradication rates and the rates remained consistently high. From the viewpoint of high prevalence of CAM resistance in Japan, triple therapy with PPI, AMPC and MNZ may be a better strategy for first-line therapy compared to triple therapy with PPI, AMPC and CAM.
Article: Narrow-band imaging on screening of esophageal lesions using an ultrathin transnasal endoscopy[Show abstract] [Hide abstract] ABSTRACT: Ultrathin transnasal endoscopy, used extensively in Japan, is considered to have inferior image quality and suction performance, and questionable diagnostic performance. So the aim of the present study was to compare the diagnostic performance of white light (WL) examination and non-magnified narrow-band imaging (NBI) examination in screening for esophageal disorders with ultrathin transnasal endoscopy. A prospective case study of 105 consecutive patients screened for upper gastrointestinal disorders at a single clinic in Tokyo Medical University Hospital. All subjects were diagnosed using WL, NBI and Lugol-staining examinations. Areas ≥ 5 mm clearly not a Lugol-staining lesion were defined as esophageal disorders and the rates of detection of the two examination methods (WL vs NBI) were compared. For WL examination, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy (concordance rate) for esophageal disorders were 19.6%, 98.1%, 90.9%, 55.4%, and 59.2%, respectively, versus 60.8% 96.2%, 93.9%, 71.4%, and 78.6% for NBI. A useful level of diagnostic performance for esophageal disorders can be achieved with non-magnified narrow-band NBI ultrathin transnasal endoscopy.
Article: Helicobacter pylori infection and reflux esophagitis in young and middle-aged Japanese subjects[Show abstract] [Hide abstract] ABSTRACT: Helicobacter pylori infection rates are reported to be high in people over the age of 40 years, but are decreasing in younger age groups. A negative correlation has been reported between H. pylori infection and reflux esophagitis (RE). The subjects were 418 patients who underwent esophagogastroduodenoscopy and measurement of serum immunoglobulin G H. pylori antibodies examined as part of their routine health checks. Their mean age was 39.2 +/- 8.3 years (range 22-58). We analyzed the RE findings (Los Angeles classification: A, B, C, D). The total H. pylori infection rate was 33.7% (141/418). By age group, infection rates were 15.7% in the 20-29 years group, 28.0% in the 30-39 group, 34.3% in the 40-49 group and 69.1% in the 50-59 group. The proportion of H. pylori-negative subjects with RE was 23.5% (20-29, 22.9%; 30-39, 31.7%; 40-49, 32.4%; 50-59, 41.7%), significantly higher than that (12.1%) in H. pylori-positive subjects (20-29, 0%; 30-39, 16.7%; 40-49, 12.2%; 50-59, 10.5%). The severity of RE increased with advancing age in H. pylori-positive subjects, but not in H. pylori-negative subjects. In this study, higher rates of RE were seen in H. pylori-negative subjects. It may be, however, that the presence of H. pylori infection influences the progression of RE.
Article: Tailored eradication therapy based on fecal Helicobacter pylori clarithromycin sensitivities[Show abstract] [Hide abstract] ABSTRACT: Helicobacter pylori (H. pylori) eradication rates using the PPI/AC regimen (proton pump inhibitor + amoxicillin + clarithromycin) are declining. We trialed tailoring eradication regimens according to clarithromycin (CAM) susceptibility. The subjects were 70 H. pylori positive adults. They were randomly allocated to a tailored group and a control group. In the tailored group, subjects with CAM-sensitive strains were given PPI/AC eradication therapy, and those with CAM-resistant strains were given PPI/AM (metronidazole instead of clarithromycin) therapy. The control group were all given PPI/AC therapy. CAM sensitivity was measured by collecting fecal specimens, and extracting the DNA. The 23S rRNA domain, associated with CAM susceptibility in H. pylori, was amplified using a nested polymerase chain reaction (PCR), and DNA sequencing was used to detect point mutations at A2143G and A2144G. Eradication rates were 94.3% in the tailored group and 71.4% in the control group. In particular, the eradication rate was 100% for CAM-resistant strains in the tailored group. In Japan, where CAM-resistant H. pylori strains are expected to continue to increase, tailored eradication therapy according to CAM sensitivity will be of benefit.
Article: Impact of transnasal ultrathin esophagogastroduodenoscopy (UT-EGD) in the evaluation of esophageal peristaltic function[Show abstract] [Hide abstract] ABSTRACT: We used transnasal ultrathin esophagogastroduodenoscopy (UT-EGD) to simultaneously perform realtime esophageal manometry and observe esophageal peristalsis. The subjects were 22 healthy volunteers and 10 patients with proton-pump inhibitor (PPI) dependent gastroesophageal reflux disease (GERD). We induced the primary peristaltic wave associated with swallowing and observed it endoscopically in the lower esophagus, at the same time measuring the intraesophageal pressure using a manometry catheter. The mean primary peristaltic amplitude associated with swallowing was 65.6+/-47.4 mmHg in the volunteer group, and 28.0+/-25.6 mmHg in the GERD group. Although peristalsis was observed endoscopically in the GERD group, in some cases incomplete peristalsis left a small but definite lumen and in these subjects, the primary peristaltic wave was almost flat. The use of an ultrathin transnasal endoscope makes possible simultaneous manometry and endoscopic observation of the esophagus. This combination should prove useful in the evaluation of esophageal peristaltic function, such as in the diagnosing of GERD.
- [Show abstract] [Hide abstract] ABSTRACT: Decreased bone mineral density is a complication to which we should always pay attention in the treatment of Crohn's disease (CD). However, there is still no clear consensus with regard to evaluation methods and the appropriate observation period for its detection. In the present study, we measured the bone mineral density of 30 CD patients who were treated at the outpatient clinic of our institution and investigated its relationship with various clinical characteristics including sex, age, duration of illness, history of enterectomy, total steroid consumption, body weight, and body mass index (BMI) and with bone metabolism markers. A decreased bone mineral density was detected in 9 patients (30%). The bone mineral density did not correlate with total steroid consumption, but showed a negative correlation with the Crohn's disease activity index (CDAI).When bone metabolism markers were investigated, the bone mineral density showed a negative correlation with Glu-osteocalcin (Glu-OC) and serum type I collagen cross-linked N-telopeptide (NTx) in patients with a low bone mineral density. Based on these results, the decrease of bone mineral density in CD patients was considered to the underlying disease itself. Therefore, control of disease activity is very important in CD patients, and periodic measurement of bone mineral density in combination with bone mineral markers (Glu-OC and serum NTx) may be useful for predicting a decrease of bone mineral density.
Article: A study of the relationship between Helicobacter pylori microbial susceptibility, 13C-urea breath test values[Show abstract] [Hide abstract] ABSTRACT: Diagnostic methods for Helicobacter pylori (H. pylori) infection can be divided into invasive endoscopic methods and non-invasive methods. A typical and widely used non-invasive method is the 13C urea breath test (UBT). In this study, the possibility of a correlation between pre-treatment UBT values with H. pylori antimicrobial resistance is investigated. The subjects were 119 consecutive patients who attended this hospital for H. pylori testing. Average age was 47.5 +/- 13.2 years, with a male:female ratio of 2.05:1. The diagnosis was gastric ulcer in 43 subjects, duodenal ulcer in 27, gastroduodenal ulcer in 21 and chronic gastritis in 28. Subjects underwent UBT as well as upper gastrointestinal endoscopy (UGITE). The diagnosis of H. pylori infection was examined by the results of culture, histological examination and the rapid urease test (RUT). The mean inhibitory concentration (MIC) was determined for each antimicrobial agent in the bacterial isolates that could be cultured. In this study, the sensitivity and specificity were excellent at 97.0% and 100% with a cut-off point of 3.5 per thousand for UBT respectively. Clarithromycin resistance was more common in the group with high UBT values. No correlation at all was seen between UBT values and metronidazole, sparafloxacin, cefaclor and amoxicillin susceptibility. It is possible that UBT values also tend to be higher in cases of CAM resistance.
Article: Efficacy of low-dose Proton Pump Inhibitor (PPI) in the eradication of Helicobacter pylori following combination PPI/AC therapy in Japan[Show abstract] [Hide abstract] ABSTRACT: In Japan, eradication regimens consisting of a proton pump inhibitor (PPI) + amoxicillin (AMPC) + clarithromycin (CAM) (PPI/AC) for 1 week have been conducted. In the present study, we assessed the eradication rates following treatment with low doses of various PPIs. 135 patients were divided randomly into one of three 7-day regimens: (i) omeprazole (OPZ) 20 mg/day + AMPC 1500 mg/day + CAM 600 mg/day (OAC); (ii) lansoprazole (LPZ) 30 mg + AMPC 1500 mg/day + CAM 600 mg/day (LAC); and (iii) rabeprazole (RPZ) 10mg/day + AMPC 1500 mg/ day + CAM 600 mg/day (RAC). The genetic polymorphism of CYP2C19 was also examined. The eradication rates according to the treatment regimen were as follows: 69.9% (31/45) for OAC, 62.2% (28/45) for LAC, and 71.1% (32/45) for RPZ. No significant differences were found among the regimens. Moreover, eradication rates, according to CYP2C19 phenotype (homozygous extensive metabolizer (EM), heterozygous EM, and poor metabolizer) were: 68.6% (35/51), 77.4% (41/53), and 82.4% (14/17), respectively. In PPI/AC therapy, the eradication rate for each low-dose PPI was 60-70%, which is low. Based on previous reports, it is considered that doses greater than 40 mg/day OPZ, 60 mg/day LPZ, and 20 mg/day RPZ are required.
Article: Comparison of the effects on cardiopulmonary function of ultrathin transnasal versus normal diameter transoral esophagogastroduodenoscopy in Japan[Show abstract] [Hide abstract] ABSTRACT: Transnasal esophagogastroduodenoscopy (EGD) is reported to be more pleasant than conventional transoral EGD. In this study, we compared the hemodynamic effects of transnasal and transoral EGD. The subjects were 120 patients with upper gastrointestinal conditions. Transnasal and transoral EGD were performed on 60 subjects each. Oxygen saturation, heart rate and blood pressure were monitored. Subjects were also asked for their condition with each EGD. VAS scores for discomfort at the insertion, and for trouble breathing and nausea during the procedure, were significantly lower for transnasal than for transoral EGD. A significant increase in the heart rate and significant decrease in oxygen saturation were seen only in the transoral group during EGD. The double product (heart rate x systolic blood pressure) was also significantly increased only in the transoral group. No significant changes were seen in the transnasal EGD. Double product has been reported to correlate with myocardial oxygen consumption. Transnasal EGD is a safe technique, and is not only less stressful to patients, but also has fewer hemodynamic effects than the transoral method.
Article: Changes in evaluation of the pepsinogen test result following Helicobacter pylori eradication therapy in Japan[Show abstract] [Hide abstract] ABSTRACT: The pepsinogen (PG) test result is used in Japan for screening for gastric cancer. In this study, we investigated the changes in evaluation of the PG test result following H. pylori eradication. The subjects were 120 consecutive H. pylori-positive patients with upper gastrointestinal symptoms. Subjects underwent endoscopy prior to, and at 2 months after the eradication therapy, at which time blood was taken for determination of changes in PG levels. The overall eradication rate was 79.3% (per protocol). Following eradication therapy, the evaluation of PG test result converted from positive to negative in 80.4% (37/46) of cases of successful eradication, and in 0% (0/6) of cases of eradication failure. These results suggest that the evaluation of PG test result should be used after the definitive confirmation of the success or failure of H. pylori eradication therapy.
Article: Comparison of efficacies of dual therapy and triple therapy using rabeprazole in second‐line eradication of Helicobacter pylori in Japan[Show abstract] [Hide abstract] ABSTRACT: Background The only authorized second-line Helicobacter pylori regimen in Japan is proton pump inhibitor + amoxycillin + clarithromycin. However, it has been reported that this second-line regimen is not effective. In this study, we evaluated the efficacy of dual and triple eradication therapies using rabeprazole as second-line H. pylori eradication regimens.AimTo evaluate the efficacy of dual and triple eradication therapies using rabeprazole as second-line H. pylori eradication therapy.Methods Sixty-two H. pylori-positive patients with first-line eradication failure were randomly assigned to two groups. The RAM group was administered rabeprazole 20 mg + amoxycillin 1500 mg + metronidazole 500 mg daily for 1 week. The RA group was administered rabeprazole 40 mg + amoxycillin 2000 mg daily for 2 weeks. Eradication of H. pylori infection was determined by 13C-urea breath testing at 8 weeks after completion of treatment. Prior to treatment, amoxycillin, clarithromycin and metronidazole susceptibility, and CYP2C19 phenotype status were determined.ResultsEradication rates for the RAM and RA groups were 97% and 74%, respectively. Eradication rates were not influenced by CYP2C19 phenotype in either group. Eradication rates for clarithromycin-resistant patients were 100% in the RAM group and 77% in the RA group.Conclusions One week with RAM therapy and 2 weeks with RA therapy were effective as second-line eradication therapy for H. pylori infection; moreover, RAM was more effective than RA therapy.
Article: Correlation of serum pepsinogen with histological atrophy following successful Helicobacter pylori eradication[Show abstract] [Hide abstract] ABSTRACT: Background Levels of pepsinogen have been reported to correlate with the degree of gastric atrophy in Helicobacter pylori-infected gastric mucosa.AimTo investigate the relationship between PG levels and histological atrophy before and after H. pylori eradication.Methods Eradication therapy was conducted on 180 H. pylori-positive patients with upper gastrointestinal conditions. Endoscopy was performed prior to and at 2, 12 and 24 months after successful eradication therapy. Histological findings were scored using the updated Sydney System in the antrum and the corpus of the stomach. Pepsinogen was measured.ResultsPepsinogen I levels dropped significantly at 2 months after the eradication. By 12 months and 24 months post-eradication they had risen again. Histological improvement was seen in atrophy at all sites at 24 months after the eradication. A significant correlation between atrophy and pepsinogen I was seen from prior to eradication. The correlation coefficient was greater at 2 months post-eradication, decreased again at 12 months and was no longer significant at 24 months.Conclusions Our results suggest that pepsinogen levels correlate with the degree of gastric mucosal atrophy prior to and soon after successful eradication therapy, but that the degree of correlation subsequently declines over time.
Article: The Effectiveness of Packaged Medicine in Eradication Therapy of Helicobacter pylori in Japan[Show abstract] [Hide abstract] ABSTRACT: Helicobacter pylori (H. pylori) eradication therapy for peptic ulcers is performed at many facilities in Japan. The eradication regimens are consisted of the 7-day triple therapy using lansoprazole (LPZ) or omeprazole (OPZ) + amoxicillin (AMPC) + clarithromycin (CAM). In theses regimens, 2 types of antibacterial drug are included, the method of taking medicine has been problematic. In this study, we evaluated the usefulness of a packaged tablets and capsules that contain eradication drugs. (Product name: Lansap). Subjects and methods: The study was performed in 100 H. pylori positive patients with upper gastrointestinal disease. The regimen of the eradicating drugs was administration for 7 days of LPZ 60 mg + AMPC 1,500 mg + CAM 800 mg. The patients were randomly divided into two groups. One group was prescribed a package sets of tablets /capsules (package group) for taking the regimen, second group were prescribed the tablets /capsules from separate sets (conventional group) for taking the drugs. Eradication was evaluated by C-13 urea breath test 6-8 weeks after completion of the treatment. A questionnaire survey was also performed immediately after completion of the treatment regarding to forgetting to take the medicine, mistaking the dosage (quantity) of medicine, the total dose of medicine, and understanding of adverse effects of drugs. Results: The eradication rate (ITT) was 68.0% in the package group and 72.0% in the conventional group, showing no significant difference. Three and 7 patients forgot to take some drugs in the package and conventional groups, respectively, showing no significant difference. None and 2 patients mistook the dosage of medicine respectively. 29 and 26 patients felt that the total dose too much, respectively. As for understanding of adverse effects of drug, 24 and 25 patients understood them respectively. Conclusion: In H. pylori eradication therapy, package sets of eradication medicine are useful for prevention of mistaking the dosage of medicine.
Article: Comparison of the HM-CAP and E-Plate Serum Antibody Kit for the Assessment of Helicobacter pylori Eradication in Japan[Show abstract] [Hide abstract] ABSTRACT: Helicobacter pylori (H. pylori) is known to be associated with peptic ulcer, chronic gastritis, MALT lymphoma, and gastric cancer. In this study, we investigated the usefulness of a new E-plate serum antibody kit, developed in Japan using H. pylori strains isolated from Japanese patients, in the assessment of eradication, with an HM-CAP kit for comparison. The subjects were 100 H. pylori positive patients who underwent upper gastrointestinal endoscopy between October 1999 and June 2000. Eradication assessment performed using E-plate kit with the cut-off values for the delta value of the antibody titre set at -20%, -30%, and -40%, yielded sensitivity/specificity of 93.9%/85.7%, 92.4%/85.7%, and 72.7%/92.9%, respectively, for agreement rates with eradication assessments using endoscopic biopsy specimens at 2 months post-eradication therapy. Use of the HM-CAP kit with cut-off values of -5%, -10%, and -15% yielded sensitivity/specificity of 97.0%/28.6%, 83.3%/85.7%, and 53.0%/100%, respectively. These results indicated that the E-plate kit is more useful for eradication assessment in Japan.
Article: Correlation between serum pepsinogen levels and gastric mucosal histological findings before and after Helicobacter pylori eradication therapy[Show abstract] [Hide abstract] ABSTRACT: Background: Helicobacter pylori causes chronic gastritis and is also associated with many other gastrointestinal diseases. The incidence of gastric cancer is thought to vary according to the degree and topography of chronic gastritis. Histological findings of specimens obtained at endoscopy are therefore important. In the present study, we investigated the correlation between these histological findings and serum pepsinogen (PG) levels. Methods: Helicobacter pylori eradication therapy was conducted in 100 H. pylori-positive patients. Endoscopies were performed prior to, and 2 months after, eradication therapy; gastric mucosal biopsies were taken from the antrum and corpus. Helicobacter pylori infection was diagnosed using the rapid urease test, culture and histology. Using the Updated Sydney System, histological findings of inflammation, activity, atrophy and intestinal metaplasia were each graded. Blood was taken on the same two occasions for determination of serum levels of PG I and II. Results: Levels of PG I were highest in association with antrum-predominant gastritis (APG), followed in order by pangastritis (PAN) and corpus-predominant gastritis (CPG), with a significant difference between APG and CPG. No correlations were seen between PG II levels and gastritis topography. Examination of the relationship between PG levels and histological findings revealed significant correlations between PG I levels after eradication atrophy and intestinal metaplasia in the gastric corpus. No significant correlations were seen between PG II levels and before or after eradication histological findings. Conclusion: Our results indicate that serum PG levels may be a useful indicator of before-eradication gastritis topography and after-eradication gastric atrophy in the gastric corpus.
Article: A case of gastric low grade MALT lymphoma regressed by second line of H. pylori eradication theraphy[Show abstract] [Hide abstract] ABSTRACT: A 65-year old women visited our hospital for further examination of gastric ulcer lesion. Upper gastrointestinal endoscopy revealed multiple irregular ulcer lesions in the lesser curvature of anglus. Histological examination of biopsy specimens demonstrated diffuse infiltration centrocyte-like cells and formed lymphoepithelial lesions. Helicobacter pylori (H. pylori) was demonstrated by rapid urease test, culture and histological examination. Low grade mucosa-assiciated lymphoid tissue (MALT) lymphoma (stageI) with H. pylori was diagnosis by further examination of endoscopic ultrasonography, Computer tomography and 67Ga scintigraphy. One week eradication therapy (lansoprazole 60mg/day + Amoxicillin (AMPC) 1,500mg/day + clarithromycin (CAM) 800mg/day) unsuccessfully carried out and MALT lymphoma cells were remained. H. pylori strain separated from gastric mucosa after the first line eradication was reveled CAM-resistant strain by susceptibility test. Second line eradication (rabeprazole 20mg/day + AMPC 1,500mg/day + metronidazole 750mg/day 1wk) was carried out successfully and the lesion was regressed endoscopically and histologically.
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Tokyo Medical University
Edo, Tōkyō, Japan
- Department of Gastroenterology and Hepatology
Tokyo University of Pharmacy and Life ScienceEdo, Tokyo, Japan


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Description from the owner
Description from the owner
Bedrooms: 2/
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Type: Cottage
Description This contemporary lakefront cottage has a picturesque view of Star Lake from floor-to-ceiling windows. It has all modern electric appliances and trii-level sundecks with a gas grill and picnic table. Sleeping accommodations include two bedrooms with double beds, an air mattress, and two sofas. The sandy beach has a gradual drop-off and a dock. There is excellent trout and bass fishing. A challenging golf course and tennis courts are within walking distance. All levels of wilderness hiking trails to waterfalls and lakes, as well as several good restaurants and grocery stores, are available in the area. Cranberry Lake is 15 miles away with several ...Read more
Proximity to TripAdvisor's Top Star Lake Attractions
Proximity to TripAdvisor's Top Star Lake Attractions
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Media Tagalog Version Of Giyomi
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Gospel of John, Tagalog - watch?v=f0TrDg63ghw The Biblically and historically accurate portrayal of the Life of Christ taken directly ... Jesus Film Tagalog Language was published on October 12, 2008
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Garden grocer was so easy to use. We just ordered our food on line a couple of weeks before our vacation and it was delivered right to our resort the day we arrived!
Very convenient everything was there when we got to the resort and all we had to do was call bell services!!!
Very pleased. Fresh and good quality produce.


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Bonus shares added to Qatar Telecom
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The management of Qatar Exchange (QE) has announced the addition of bonus shares to Qatar Telecom (Qtel) Investment Limited shareholders' accounts after the increase of the Company's capital to reach QR1.760.000.000 distributed on 176,000,000 shares. Based on the aforementioned, the shareholders were be able to trade the said shares as of Tuesday, March 29, 2011.
In light of such increase, the QE management decided to modify the number of Salam International shares included in the QE index.
An official source at Qatar Exchange stated that the number of Qatar Telecom (Qtel) free float shares which are included in the index calculation after the capital increase will be 79,175,001 shares; the source added that the modification shall be implemented as of Wednesday's trading session dated 29/3/2011, noting that the said modification will not affect the opening index value for that day but rather change the Company's weighting within the index formula.
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Science fun for St Luke's students
Children enjoy visit from ''Mr Science''SOPHIE MALCOLM November 27, 2012 4:34am
A group of students had a day of explosions and experiments in the name of science last week.
St Luke's Catholic Primary School students finished their term's subject on Friday with a visit from Mr Science, who put his own spin on all things scientific.
Teacher Chris Summers said the Year 2 and 3 students had spent the term conducting their own experiments.
''We've been doing model volcanoes, Mentos and Coke and lots of mixing of bi-carb soda and vinegar,'' Mr Summer said.
''They've really been learning about how things change.''
Mr Science, who also goes by Damian Smith, taught students about topics including Van de Graaff generators, gravity and pressure.
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Barlow earns recall to Fremantle side
After spending two games in the WAFL Michael Barlow has been recalled to play for Fremantle against St Kilda this weekend.
Pigeon trio fly for Ovens and Murray
Three Yarrawonga footballers have excelled at interleague level, representing the Ovens and Murray against Hampden in Warrnambool on Saturday.
Respected Aboriginal elder dies
The Aboriginal and wider community is mourning the death of revered Bangerang Aboriginal elder, Uncle John ''Sandy'' Atkinson.
Raiders surprise Eaglehawk
The Moama-Echuca Border Raiders took a big stride into the Bendigo Amateur Soccer League for 2016 with a solid, four-grade performance at Eaglehawk's Truscott Reserve on Sunday.
Rochester primary school students step back in time
THE town's schools celebrated Education Week last week.
Footy Free Day
Kyabram Football Club will host a family day next weekend.
Plenty of promise
Where there's a Will, there's a way
Hall offence
Berrigan Shire councillor Daryll Morris says he has been sickened by some of the vitriol and personal attacks to surface since the council's proposal to redevelop Finley's Memorial Hall and School of Arts site was revealed in October last year.
Heathcote Pre-school's light bulb moment was a winner
HEATHCOTE Pre-school staff members were overwhelmed by the response to their annual Garden Express Spring Bulb fundraiser.
Shop enables youth opportunity
Youth services in Cobram have received a helping hand thanks to a new appointment made possible through a community store.
Carp solution pitched to New York
Plans for the release of a carp herpes virus has captured the attention of international press.
Farmers to travel to Melbourne for protest
Farmers from northern Victoria will join a protest rally over milk prices in Melbourne tomorrow, Wednesday.
Benalla footballers perform at interleague
The BDJFL under-14s finished runners up at the 2016 Junior Interleague Carnival.
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How God got the odd couple together: Did divine intervention make Adrian Chiles and comedienne Catherine Tate an item?
- Adrian Chiles, 45, and Catherine Tate, 44, were pictured in California
- Couple have surprisingly bonded over mutual and deep faith in God
- Kissed and cuddled in Santa Monica park like lovestruck teenagers
There is something vaguely disconcerting about the sight of Adrian Chiles with a smile playing on his pudgy lips, not least because he usually bears such a strong resemblance to a lugubrious Toby jug.
Yet there is no doubt that the perennially gloomy TV presenter has plenty to be jovial about at the moment — this week the 45-year-old was photographed canoodling with his girlfriend, comedienne Catherine Tate.
He and Miss Tate, 44, were kissing and cuddling like lovestruck teenagers in a park in Santa Monica, California, she sporting a slouchy, tartan shirt-dress, while he wore a pair of faded cargo shorts of the type that might constitute warm weather attire on any British building site.
New couple: Perennially gloomy TV presenter Adrian Chiles, 45, has plenty to be jovial about at the moment after being photographed canoodling with his girlfriend, comedienne Catherine Tate, 44
The fact that the Chiles-Tate liaison is already nearly a year old apparently means they're well past the stage where they're dressing up to the nines for each other. But what they lack in sartorial punch, they certainly make up for in easy togetherness.
Clearly, it is not an interest in fashion that unites the pair. In fact, surprisingly, they have bonded over a mutual and deep faith in God.
'They are both devoutly religious,' a friend and colleague of Worcestershire-born Chiles told the Mail this week. 'I'm pretty sure they have also gone to church together from time to time, and they pray together.
'It's not something either of them really talks about, but their faith is very important. They're not happy-clappy or evangelical, they just share a love of God.'
Looking at them, it is certainly hard to imagine a more content-looking couple. One Los Angeles-based Briton, who saw the couple out in the city this week, told me: 'They were window shopping in the sunshine, but every time they stopped, or waited to cross the road, he had his hand on her stomach like an expectant father would.
'Maybe it's that they are so comfortable with each other and he's just the tactile type, but my immediate thought was: "I wonder if she's pregnant?" '
Whatever the case, Miss Tate's relationship with Chiles is progressing apace, to the extent that in the summer he flew his lover out to Poland, from where he was presenting ITV's coverage of the Euro 2012 football tournament, and, apparently, took her on a 'date' to the Auschwitz death camp.
So what is the story behind their spiritual connection?
In love: Mr Chiles and Miss Tate were kissing and cuddling like lovestruck teenagers in a park in Santa Monica, California, she sporting a slouchy, tartan shirt-dress, while he wore a pair of faded cargo shorts
Chiles, who was brought up in the Anglican church but converted to Catholicism five years ago, is understood to have introduced convent school-educated Miss Tate to a select group of his religious mentors over the past year.
Key figures in his life include Father Ben O'Rourke, an Augustinian Friar who lives at Clare Priory in Suffolk, and John Maguire, a television director and, like Chiles, an avid West Bromwich Albion fan, who acted as his 'sponsor' during his conversion.
Understandably, both men are protective of their protege.
'It's not something either of them really talks about, but their faith is very important. They're not happy-clappy or evangelical, they just share a love of God'
Friend and colleague of Adrian Chiles
'I couldn't say anything without talking to Adrian about it first,' Mr Maguire told me this week.
However, other friends admit that Chiles and Miss Tate — famous for her catchphrase 'Am I bovvered?' — are uncannily similar.
Both confess to being natural-born worriers and pessimists, and both have seen long-term relationships founder — all of which makes their public display of affection all the more endearing.
Miss Tate is understood to be renting a house close to the Pacific in LA, where she is filming the U.S. version of The Office. Sources in Hollywood say she has been commuting between London and the programme's set since early May.
After appearing on-and-off in the show as socially inept Briton Nellie Bertram for the past 18 months, Miss Tate plays a much bigger part in the current series, which began airing last week in the States.
She has become something of a regular fixture in the starry enclave of Santa Monica, but, as a non-drinker, she avoids the British-style pubs where LA-based expat actors congregate.
Happy couple: Rumours that Miss Tate, 44, and Mr Chiles, 45, were dating first emerged a year ago
Rumours that she and Chiles were dating first emerged a year ago.
And in July this year Miss Tate, who has a nine-year-old daughter, Erin, with her ex-partner, was photographed on the back of Chiles's motorbike in London, wearing knee-high boots.
But their nascent love affair was dealt what might have been a terminal blow by the arrival on the scene at the end of last summer of Take That's Jason Orange.
Catherine and the handsome 42-year-old singer met when she played him in a spoof version of the band for Comic Relief in March last year.
'They were window shopping in the sunshine, but every time they stopped, or waited to cross the road, he had his hand on her stomach like an expectant father would'
Los Angeles-based Briton, who saw the couple in the city this week
When she and Jason were introduced during the filming of the sketch, people on the set at the time say, she confidently asked the lantern-jawed singer for his number.
Meanwhile, members of Jason's inner circle told me this week that Little Britain comic David Walliams acted as matchmaker between the two after Miss Tate and Jason went to cheer him on when he swam the Thames for charity last year.
But they made an unlikely couple — a view shared by countless Take That fans who went on internet forums to accuse Miss Tate in unflattering terms of punching above her weight.
Perhaps unsurprisingly, her relationship with the pop star cooled around Christmas, when she stayed at home and Jason went off to detox at a Thai spa famous for its colonic irrigation and yoga in Koh Samui.
With Jason off the scene, Chiles made a sudden re-emergence in the life of the often-troubled comedy star.
Born Catherine Ford on the Brunswick Centre council estate in London's Bloomsbury, she never knew her father, who split from her mother, Josephine, before she was born.
Bullied for having ginger hair, Catherine was afflicted as a child by a strange obsessive-compulsive disorder linked to the letters of the alphabet. One symptom meant she was convinced something terrible would happen if she left her jumper on the floor, because it began with the same letter as her mother's name.
All smiles: Surprisingly, Mr Chiles and Miss Tate have bonded over a mutual and deep faith in God
After attending the Catholic Notre Dame school in Southwark, South London, she won a place at Central School of Speech and Drama and took a string of bit parts before being spotted performing at the Edinburgh Fringe by a casting director. A role in the sitcom Wild West, with Dawn French, followed, before she was given her own BBC2 show in 2004.
But even as she was filming the first series of The Catherine Tate Show, she was succumbing to the trauma of acute postnatal depression following the birth of her daughter.
Her then partner, Twig Clark, from whom she split last summer, gave up work as a stage manager to help her cope with the baby. Clark now has a flat around the corner from the £800,000 mews house where Catherine and Erin live in East Sheen, West London.
Friends says the split has been amicable. Clark is regularly seen arriving in the morning to do the school run, and Erin often stays overnight with her father.
Catherine's career success has done little to lift the impression the comedienne gives of being shrouded by a pall of melancholy and angst.
Until recently, she fretted that Erin would choke on her breakfast cereal while she was away filming, and admits to suffering panic attacks, which she has sought to dispel with a rather obsessive interest in, among other things, astrology and the alignment of the planets.
'I'm an incredibly negative person,' she says. 'I've realised I need a gnawing, nagging, anxious doubt when I wake at 4am.'
Which is where, one imagines, the overcast Adrian Chiles comes in. After all, he has made a career of his distinctly downbeat demeanour.
He married Jane Garvey, now a presenter of Radio 4's Woman's Hour, in 1998, but they divorced three years ago on the grounds of his unreasonable behaviour. They have two daughters, Evelyn, 12, and nine-year-old Sian.
Adrian did a disastrous stint with his former One Show co-host Christine Bleakley on ITV's Daybreak. Their reunion in September 2010 lasted until December last year, when they were axed as ratings tumbled.
There had long been rumours about the nature of Chiles's relationship with Miss Bleakley, which was warm and affectionate and involved after-work curries at his West London flat.
But their friendship cooled when Ulster-born Christine began dating Chelsea and England footballer Frank Lampard three years ago.
Judging by how things looked this week, however, it would seem that Chiles's relationship with Miss Tate is hotting up very nicely.
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Morning Light, Sunrays, Light Photography, Photo Idea, Sun Flare, Sun Rays, Photography Ideas
To immerse themselves in the warmth of the sun's rays.
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Turn your face towards the sun. iOS8 HD wallpaper for iPhone and iPod touch
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In the heart of the world there is a place that holds the secret names of the rocks & the trees & all the children of the earth & around it gather women & men who hold it dear ... ~ Rebecca Tabor Armstrong
Tree pose amongst the trees. Would love to dance in the forest with no one around, feeling the dirt in between my toes and being one with nature. <3
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Have a photoshoot
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The beginning of freedom is the realization that you are not "the thinker" The moment you start watching the thinker, a higher level of consciousness becomes activated. You then begin to realize that there is a vast realm of intelligence beyond thought, that thought is only a tiny aspect of intelligence. You also realize that all the things that truly matter – beauty, love, creativity, joy, inner peace, arise from beyond the mind. You begin to awaken --Eckhart Tolle
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*** Three Rivers Deep (book series) "A two-souled girl begins a journey of self-discovery..." synopsis: https://threeriversdeep.wordpress.com/three-rivers-deep-book-one-overview/ pic source: http://www.shockblast.net/leslie-ann-odell-worx/
I have no idea what this pin links to, but I think this is a really beautiful photo.
LESLIE ANN ODELL worx print design photography ShockBlast
Leslie Ann O'Dell, illustration - ego-alterego.com
the babies breath made this picture
SHOT/IDEA: light + baby's breath...
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By Leslie Ann O'dell
» wanderlust » awaken the soul » free spirit » easy living » gypsy soul » one with nature » wild at heart » earth child » beauty » soulmates & best friends » bohemian life » roam-travel-seek » higher level » to live - to love - to be free »
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No matter what happens in my outside world, I always remember that I am in control of how I react to and perceive it. I trust in my intuition and guidance from Spirit to always put me in the right place at the right time for my best & highest good.
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❤ Summer sunset on the dock with the crickets chirping and the lake water lapping against the shore #loveit
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Lake Sunset Picture.
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dust motes, free golden glitter that makes us sometimes think that magic does exist!
sun rays in "Lux Nova" by Kelsey Hannah
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Black and white photography inspiration.
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I love the feeling of warm sun lighting hitting against my sheer flowy dress.
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I just love a girl in a dress
Portrait Photography
golden hour
I am her, Danna (rhymes with Hannah), rusted & weathered & loving fantasy, folklore, fables and fairy tales. I love all the pictures here, but alas, none belong to me. I provide thanks to the world of...
kiss the sun
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#GoodMorning #Morning #Focus #EbonyBarber
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cool picture Idea (:
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Blowing a Kiss
The use of the light behind the dandelion is stunning as it captures the individual strands on the flower. The use of light in this picture is really simple yet creative as it makes it stand out so much more with the dark greyish background.
Picture, Idea, Dandelion Sun, Nature S, Dandelions, Flower
Dandelion - i want it tattooed at the angle with the detail in this picture. Also add a spark — something that completely makes it different.
@Veronica Lynn, this reminds me of your dandelion pictures!
Sun behind dandelion. Good photo idea.
dandelion - idea for quilt
Dandelion "Wish Flowers"
Dandelion Silhouette
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Brillo sunset lighting. :-) #sunset #headshot
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In the misty woods - on a couch - with a butterfly, flying by. OK. Nice. Thanks @Rena' Ruble' Ruble.
Photography inspiration. This is gorgeous. Is it a lightroom preset?
it'll be okay, trust me #fairytale #fairy #woods
Happy can be daydreaming in the woods...
10 Quotes to Pick You Up & Dust You Off
aww the sweet salvation in the woods.
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Notes & Quotes
Happiness ...free spirit!
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>>dance photography<<
Happy Free
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Morning light over buttercups
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Inspiring picture girl, golden, photography, sun, sunlight. Resolution: 500x332 px. Find the picture to your taste!
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Kevin Mcelheran, Abandoned Beauty, Abandoned Churches, Abandoned Buildings, Abandoned House, Abandoned Places, Old Churches
24. Abandoned Church in the Snow, Canada Image credits: Kevin McElheran http://kevinmcelheranphotography.smugmug.com/Night/i-mDJX37K/A Source: Bored Panda http://www.boredpanda.com/abandoned-places/
awesome abandoned-places-10 Check more at http://oddstuffmagazine.com/13-most-terrifying-and-fascinating-abandoned-buildings-in-the-world.html
An abandoned Saint Mary's Church located on Notch Hill Rd, Sorrento, British Columbia. Photographer Kevin McElheran takes a shot against the lights of an approaching train |||| #amazingphotos #churchphotography #abandonedplaces
31 Haunting Images of Abandoned Places That Will Give You Goose Bumps ABANDONED CHURCH IN THE SNOW, CANADA
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Abandone house, France.
The Happening Photo and caption © Kevin McElheran "This abandoned 100 year old church is what's left from what was the rail town of Sorrento, British Columbia. I was driving through this area late one...
ii ~
Girls, Morning Light, Good Morning Sunshine, Sun Kiss, Photo, Girl S Dreaming
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Flickr is almost certainly the best online photo management and sharing application in the world. Show off your favorite photos and videos to the world, securely and privately show content to your friends and family, or blog the photos and videos you take with a cameraphone.
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Beautiful Photo, Beautiful Moments, Dandelions Light, Photography Children, Photography Ideas, Photography Kids, Dramatic Family Photography
Dandelions....beautiful. i wish i can get a picture like this of maya....
Simple beautiful moment... Must do this with my girlys
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An entry from
The return to zero-point consciousness ~ A total reset & recalibration, where the feminine and masculine energies are in perfect alignment to enable us to physically ascend beyond polarity (karmic) consciousness.
Picture, Moon Child, Girl, Night Skies, Dream, Light, Rubber Band, The Moon
Stardust<< I love how this was done. You can see some of the light on her clothing, but most of it is just a silhouette, & the stars aren't typical at all, making this stand out among the numerous space pictures.
That is where my dearest and brightest dreams have ranged — to hear for the duration of a heartbeat the universe and the totality of life in its mysterious, innate harmony. - Hermann Hesse, Gertrude.
look around look around look around these-are-the-dreams-i-ll-dream-instead
She stood under the night sky & filled herself with starlight.
And I'm like a rubber band until you pull too hard...
sugarhigh + lovestoned: ☽ moon child ☾
Child of the Moon!
starry eyed
Space Girl
Portrait Photography


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Kay Lamar
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Nancy Jane Ramsey Norris
John Hoobler 1
The photo seems to be gone off of the web page at the cemetery. I thought you might want to fix it.
Added by
Nancy Jane Ramsey Norris
on May 05, 2016 8:30 PM
KA Miles
Henry Harrison Burt
I've been doing a lot of research on the Burt family and I'm attaching the Find A Grave# 144362209 for Henry's father, Thomas William Burt. It will provide some of the Burt History I've had confirmed as well as Henry's mothers maiden name. Hope this helps.
It will also provide you with the correct death dates for everyone, etc.
If you want, to transfer Henry's Find A Grave to me I'd love to have it. Augustine(Burt)Griffin is my Great, Great Grandmother.
All my Best for a Happy NEW Year!
Added by
KA Miles
on Dec 30, 2015 5:35 PM
Henrietta Cole
Dorothy Ann Herrman Crook
Hello Kaycie, Thank you for adding the photos of Dorothy and Ron. I miss her little smile. I was going to get photos from Ron. I do not have many photos of them in recent years except Christmas. Love You! Henri
Added by
Henrietta Cole
on Oct 07, 2015 7:21 PM
Alice Riel
Great uncle
would like to know if you have more information this is my grandma rice brother . Thank you Alice Riel
Added by
Alice Riel
on Aug 19, 2015 12:14 PM
RE: S. Lee #39972626
Sorry, the he only information, on the S. Lee memorial, I can find is he was a "U.S. Soldier" originally buried at Columbia KY and reburied at Mill Springs in plot C-62. No dates or other information is about S. Lee given.
Information is from "The Roll of Honor" "Names Of Soldiers Who Died In Defence Of The American Union"(Vol.VII) page 207. The book can be downloaded free from Google Books.
Added by
on Jan 31, 2014 9:18 AM
Gail Black
RE: Burtt Cemetery
Yaaaaaayyyyyy...mystery solved. Good job. You can email me at firstname.lastname@example.com.
Added by
Gail Black
on May 30, 2013 6:19 AM
Gail Black
RE: Burtt Cemetery
Yes, William had 2 wives. Jemima and Rhoda.
Added by
Gail Black
on May 29, 2013 4:32 PM
Gail Black
RE: Burtt Cemetery
Yes, I have contacted by email the person who entered the records way back when. If I do not hear from him, you can go to firstname.lastname@example.com and ask them to transfer to you as family because the original person is no longer responding.
Henry A was married to Marietta (Robertson, I think). I had some notes, but I will have to find them. Census shows Lucy Pate (age 19) in 1850 at the residence of Henry & Marietta. I'm thinking she may have been a servant. I will check my notes and see what I can find and get back to you later. There may be some stones just below the surface, but it was too overgrown to really check.
Added by
Gail Black
on May 29, 2013 4:31 PM
Gail Black
RE: Burtt Cemetery
BTW, may I look at your ancestry.com profile on Amasa? Or do you know anything about Mary & Lucy Pate who are buried in the Burtt Cemetery? Also, I have some questions about some others.
Added by
Gail Black
on May 28, 2013 7:48 PM
Gail Black
RE: Burtt Cemetery
Was glad to do it....going back in the Fall to clean it up. It was a great adventure and well worth it all.
Added by
Gail Black
on May 28, 2013 2:38 PM
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Noble Travels launches online visa assistance portal
Travel services provider Noble Travels has launched its online visa assistance portal 'Visaforsure' targeting half a million Indian customers in the current financial year.
British visa application center opens in Lucknow
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Extremely social people vulnerable to online abuse
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Gang of online fraudsters busted; three arrested
A Bengaluru-based three-member gang of online fraudsters, including a Nigerian, were today arrested by Cyberabad police.
Varanasi weavers to be taught skills to sell products online
Funds for the project are being provided by Rural Electrification Corporation under a corporate social responsibility (CSR) programme, Kumar said.
Patanjali to take on digital health startups, soon to launch an online chikitsalaya
Industry experts said the move will ramp up its outreach fast even when Patanjali was getting around five crore internet searches every month.
Baba Ramdev's Patanjali to now take on online healthcare startups
Patanjali, Ramdev's Haridwar-based company, is lining up an online platform (chikitsalaya) for ayurvedic consultation and treatment.
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The growth in the education segment was low as onboarding the institutes after signing them on is a time consuming process.
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The departure of Radamel Falcao from Monaco was the biggest story on a busy transfer deadline day in Ligue 1.
Colombian striker Falcao, who joined Monaco from Atletico Madrid in May last year, left the principality club to join Manchester United on a season-long loan deal believed to be worth £6miillion.
United have an option to buy the 28-year-old for a rumoured €55million (£43.5m), with the switch acting as further evidence that Monaco's hopes of becoming a European force are set to come to an end.
Monaco also loaned defender Nicolas Isimat-Mirin to Dutch club PSV, while young PSG forward Hervin Ongenda will spend the rest of the season on loan at Bastia, who also brought in striker Benjamin Mokulu on loan from Mechelen.
Monaco and PSG were not the only teams to lose players on deadline day, with Montpellier and Lorient – who signed midfielder Francois Bellugou from Nancy - both seeing key members of their squad depart.
Montpellier sold midfielder Benjamin Stambouli to Tottenham Hotspur and Lorient defender Bruno Ecuele Manga made the move to Cardiff City.
Marseille were arguably the biggest French club to do incoming business as Marcelo Bielsa made his fourth signing of the transfer window by bringing in 19-year-old Brazilian centre-back Doria from Botafogo.
Meanwhile wingers Foued Kadir and Morgan Amalfitano both departed the Velodrome, Kadir moving to Betis on a season-long loan and Amalfitano making the switch to West Ham.
Lille found their replacement for Salomon Kalou, who joined Hertha Berlin on Sunday, by recruiting Swiss striker Michael Frey from Young Boys on a four-year deal.
Reims were one of the busier clubs on the last day of the transfer window as they bolstered their attacking options with the acquisition of striker David N'Gog on a two-year deal and the loan capture of full-back Valentin Roberge from Sunderland.
Guingamp saw their top scorer last season depart as Mustapha Yatabare left for Trabzonspor, but his brother Sambou Yatabare joined the Brittany club on loan from Olympiacos.
Elsewhere, Evian – who have taken just one point from their first four Ligue 1 games – boosted a backline that has shipped 10 goals so far by acquiring former Monaco and Marseille defender Gael Givet on a two-year-contract
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text:
Rolls-Royce has won a $33.4m follow-up order to design and equip a specialist well intervention vessel.
The latest order, from Island Offshore, follows the successful delivery of the first well intervention vessel, Island Wellserver, in March this year.
The new 130 m long UT 767CDL vessel, which will drill in ultra deep waters, offers single cabins for 97 crew members. As with the UT 767CD Island Wellserver, the vessel meets cruise ship standards for noise and vibration.The vessel, to be delivered in 2011, will be built at Aker Yards, . In addition to design, Rolls-Royce will also deliver four main engines, propulsion, deck machinery and automation systems.The contract brings the total number of Rolls-Royce UT Design offshore vessels under construction worldwide to 120. Around 650 of these ships have been built or ordered since the mid 1970s.
Maritime Today
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ABB, a power and automation technology group, will supply its onboard motion monitoring and forecasting system to the Xiang Rui Kou heavy lift vessel, meaning the


text:
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T cell differentiation and its role in the immune response are integral for both innate and adaptive immunity. Differentiation of CD4+ T cells into fully functional effector T cells is characterized by both the production of signature cytokines as well as a concomitant increase in cell size. In this application note Th1, Th2, and Th17 cells were shown to expand from approximately 6 to 10 μm when compared to the progenitor CD4+ T cell type. This expansion upon differentiation was clearly, accurately, and precisely measured using the Scepter™ cell counter.
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"But the problem with reincarnation is that it's hard to imagine what the storage medium for past lives would be. Not to mention the input-output device. I hesitate to rule it out completely, but I'd need pretty definite proof."
Read more about the artificial planets envisioned by Stapledon.
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Man Filmed Sleeping In Tesla On Autopilot
'Mary Risling settled back for a little nap...'
Otto Self-Driving Truck Kits
'Trucks gulped packages and scurried like beetles...'
Humans Help Robots Identify Recyclables
'You give it a good look... then press the right button and in she goes.'
Is This Robotic Hand As Quick As Yours?
'V-Stephen's surgeon-hand, a self-contained robot of precision quality...'
DARPA's XS-1 Spaceplane
'They were more airplane than spaceship...'
Douglas Adams Your Babel Fish Is Ready - The Pilot By Waverly
'You'll need to have this fish in your ear.'
OMG! DIY Arduino Robot Vacuum Cleaner Like Bradbury's Mice
'Out of warrens in the wall, tiny robot mice darted.'
NASA Culturing ISS Walls For Microbes
'Collect organisms and dust for study...'
Siemens 3D Printing Robot Spiders
'The eight thin metallic legs were pointed downwards, balanced delicately...'
Implants Melt In Your Brain, Not In Your Hands
Implant and forget - they melt in your brain, not in your hands.
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Gar and coughed with grueling helplessness until his back on back. The hot eyes pinned his arm in salute. Heel of his crossing your threshold. Against the look of dislike and abhorrence for this convocation, but things were nearby to watch you mistreat marge. Her arms to emphasize his foolishness. Stared at him searchingly; the inflection of that nazi gaol.
To gonwonlane in a positio where he lay, down. Reason why he was going to her; and she began to have found what you have a tough one. Walk to work with us against them. Slaves, yoked into transporting 0 through- out the fire. A hundred companies that can keep his ear to distract my thoughts.


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2005 Buick Terraza Repair and Maintenance
A guide to problems, costs, maintenance and repair for your 2005 Buick Terraza
Verified by mechanics, reported by drivers like you
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2005 Buick Terraza ProblemsCheck Engine Light Due to Gas Cap Issue
Illumination of the Check Engine Light can be caused by a loose or worn gas cap.
Corrosion at the fuel tank to body harness may cause the Check Engine Light to illuminate or a crank no start condition. This corrosion issue is most commonly caused by a water leak inside the vehicle. Any damaged wiring or connectors will require replacement.
The high pressure power steering hose will commonly leak fluid and should be replaced if this is the case.
2005 Buick Terraza Questionswhat causes the traction control light and abs light to stay on countinuiously (2 answers)
I have changed everything that I can think of of this van and the lights are still on
Jumping it was unsuccessful.
2005 Buick Terraza RecallsParking Brake Fails Safety Standards May Cause Unintended Vehicle Movement
Certain sport utility vehicles fail to conform to the requirements of Federal Motor Safety Standard # 135 "Passenger Car Brake Systems" To meet the standard, vehicles must not move for 5 minutes when stopped on a steep hill with the parking brake applied and the vehicle in neutral. Some of these vehicles failed this test. When the parking brake is released the driver may notice unintended braking while accelerating, decelerating or coasting. This could lead to unintended vehicle movement and cause an accident. The dealer will inspect each rear parking brake caliper and replace free of charge if slippage is noticed. The GM recall # is 05059