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Chapter 11. Motor Control and Plasticity
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Jane Brody The Holy Grail in any progressive disease is to find it early enough to start effective treatment before irreversible damage has occurred. For Parkinson's disease, which afflicts 1.5 million Americans and growing, a new study has brought this goal a little closer. The study, conducted among more than 54,000 British men and women, identified a slew of symptoms that were more likely to be present in people who years later were diagnosed with Parkinson's. The findings underscore the prevailing view among neurologists that the damage caused by this disease begins long before classic symptoms like tremors, rigidity and an unsteady gait develop and a definite diagnosis can be made. The study, by Dr. Anette Schrag and fellow neurologists at the University College London, was published in The Lancet in January. As many as five years before a diagnosis of Parkinson's, those who developed it were more likely to have experienced tremor, balance problems, constipation, low blood pressure, dizziness, erectile and urinary dysfunction, fatigue, depression and anxiety. In addition, Dr. Claire Henchcliffe, director of the Parkinson's Disease and Movement Disorders Institute at Weill Cornell Medical Center, said that REM sleep behavior disorder, characterized by a tendency to act out one's dreams while asleep, is one of the strongest prediagnostic symptoms, along with a lost sense of smell and subtle changes in cognition. Dr. Melissa J. Nirenberg, a Parkinson's disease specialist at New York University Medical Center, said, "Up to 80 percent of people with the sleep disorder get Parkinson's or a similar neurodegenerative disease." © 2015 The New York Times Company
Keyword: Parkinsons; Sleep
Link ID: 20698 - Posted: 03.19.2015
Jon Hamilton Since his birth 33 years ago, Jonathan Keleher has been living without a cerebellum, a structure that usually contains about half the brain's neurons. This exceedingly rare condition has left Jonathan with a distinctive way of speaking and a walk that is slightly awkward. He also lacks the balance to ride a bicycle. But all that hasn't kept him from living on his own, holding down an office job and charming pretty much every person he meets. "I've always been more into people than anything else," Jonathan tells me when I meet him at his parents' house in Concord, Mass., a suburb of Boston. "Why read a book or why do anything when you can be social and talk to people?" Jonathan is also making an important contribution to neuroscience. By allowing scientists to study him and his brain, he is helping to change some long-held misconceptions about what the cerebellum does. And that, in turn, could help the hundreds of thousands of people whose cerebellums have been damaged by a stroke, infection or disease. For decades, the cerebellum has been the "Rodney Dangerfield of the brain," says Dr. Jeremy Schmahmann, a professor of neurology at Harvard and Massachusetts General Hospital. It gets no respect because most scientists only know about its role in balance and fine motor control. © 2015 NPR
Keyword: Emotions; Attention
Link ID: 20697 - Posted: 03.17.2015
Jon Hamilton A new understanding of the brain's cerebellum could lead to new treatments for people with problems caused by some strokes, autism and even schizophrenia. That's because there's growing evidence that symptoms ranging from difficulty with abstract thinking to emotional instability to psychosis all have links to the cerebellum, says Jeremy Schmahmann, a professor of neurology at Harvard and Massachusetts General Hospital. "The cerebellum has all these functions we were previously unaware of," Schmahmann says. Scientists once thought the cerebellum's role was limited to balance and coordinating physical movements. In the past couple of decades, though, there has been growing evidence that it also plays a role in thinking and emotions. As described in an earlier post, some of the most compelling evidence has come from people like Jonathan Keleher, people born without a cerebellum. "I'm good at routine (activities) and (meeting) people," says Keleher, who is 33. He also has good long-term memory. What he's not good at is strategizing and abstract thinking. But remarkably, Keleher's abilities in these areas have improved dramatically over time. "I'm always working on how to better myself," he says. "And it's a continuous struggle." © 2015 NPR
Keyword: Autism; Schizophrenia
Link ID: 20696 - Posted: 03.17.2015
Jon Hamilton Alzheimer's, Parkinson's and amyotrophic lateral sclerosis ravage the brain in very different ways. But they have at least one thing in common, says Corinne Lasmezas, a neuroscientist and professor at Scripps Research Institute, in Jupiter, Fla. Each spreads from brain cell to brain cell like an infection. "So if we could block this [process], that might prevent the diseases," Lasmezas says. It's an idea that's being embraced by a growing number of researchers these days, including Nobel laureate Dr. Stanley Prusiner, who first recognized in the 1980s the infectious nature of brain proteins that came to be called prions. But the idea that mad cow prions could cause disease in people has its origins in an epidemic of mad cow disease that occurred in Europe and the U.K. some 15 years ago. Back then, Lasmezas was a young researcher in France studying how mad cow, formally known as bovine spongiform encephalopathy, was transmitted. "At that time, nobody knew if this new disease in cows was actually transmissible to humans," she says. In 1996, Lasmezas published a study strongly suggesting that it was. "So that was my first great research discovery," she says. Prions, it turns out, become toxic to brain cells when folded into an abnormal shape. "This misfolded protein basically kills the neurons," Lasmezas says. © 2015 NPR
Keyword: Prions; Parkinsons
Link ID: 20675 - Posted: 03.10.2015
by Sarah Zielinski Before they grow wings and fly, young praying mantises have to rely on leaps to move around. But these little mantises are really good at jumping. Unlike most insects, which tend to spin uncontrollably and sometimes crash land, juvenile praying mantises make precision leaps with perfect landings. But how do they do that? To find out, Malcolm Burrows of the University of Cambridge in England and colleagues filmed 58 juvenile Stagmomantis theophila praying mantises making 381 targeted jumps. The results of their study appear March 5 in Current Biology. For each test leap, the researchers put a young insect on a ledge with a black rod placed one to two body lengths away. A jump to the rod was fast — only 80 milliseconds, faster than a blink of an eye — but high-speed video captured every move at 1,000 frames per second. That let the scientists see what was happening: First, the insect shook its head from side to side, scanning its path. Then it rocked backwards and curled up its abdomen, readying itself to take a leap. With a push of its legs, the mantis was off. In the air, it rotated its abdomen, hind legs and front legs, but its body stayed level until it hit the target and landed on all four limbs. "The abdomen, front legs and hind legs performed a series of clockwise and anticlockwise rotations during which they exchanged angular momentum at different times and in different combinations," the researchers write. "The net result … was that the trunk of the mantis spun by 50˚relative to the horizontal with a near-constant angular momentum, aligning itself perfectly for landing with the front and hind legs ready to grasp the target." © Society for Science & the Public 2000 - 2015
Keyword: Vision
Link ID: 20663 - Posted: 03.07.2015
By Abby Phillip Jan Scheuermann, who has quadriplegia, brings a chocolate bar to her mouth using a robot arm guided by her thoughts. Research assistant Elke Brown watches in the background. (University of Pittsburgh Medical Center) Over at the Defense Advanced Research Projects Agency, also known as DARPA, there are some pretty amazing (and often top-secret) things going on. But one notable component of a DARPA project was revealed by a Defense Department official at a recent forum, and it is the stuff of science fiction movies. According to DARPA Director Arati Prabhakar, a paralyzed woman was successfully able use her thoughts to control an F-35 and a single-engine Cessna in a flight simulator. It's just the latest advance for one woman, 55-year-old Jan Scheuermann, who has been the subject of two years of groundbreaking neurosignaling research. First, Scheuermann began by controlling a robotic arm and accomplishing tasks such as feeding herself a bar of chocolate and giving high fives and thumbs ups. Then, researchers learned that -- surprisingly -- Scheuermann was able to control both right-hand and left-hand prosthetic arms with just the left motor cortex, which is typically responsible for controlling the right-hand side. After that, Scheuermann decided she was up for a new challenge, according to Prabhakar.
Keyword: Robotics
Link ID: 20647 - Posted: 03.04.2015
by Hal Hodson Video: Bionic arm trumps flesh after elective amputation Bionic hands are go. Three men with serious nerve damage had their hands amputated and replaced by prosthetic ones that they can control with their minds. The procedure, dubbed "bionic reconstruction", was carried out by Oskar Aszmann at the Medical University of Vienna, Austria. The men had all suffered accidents which damaged the brachial plexus – the bundle of nerve fibres that runs from the spine to the hand. Despite attempted repairs to those nerves, the arm and hand remained paralysed. "But still there are some nerve fibres present," says Aszmann. "The injury is so massive that there are only a few. This is just not enough to make the hand alive. They will never drive a hand, but they might drive a prosthetic hand." This approach works because the prosthetic hands come with their own power source. Aszmann's patients plug their hands in to charge every night. Relying on electricity from the grid to power the hand means all the muscles and nerves need do is send the right signals to a prosthetic. Before the operation, Aszmann's patients had to prepare their bodies and brains. First he transplanted leg muscle into their arms to boost the signal from the remaining nerve fibres. Three months later, after the nerves had grown into the new muscle, the men started training their brains. © Copyright Reed Business Information Ltd.
Keyword: Robotics
Link ID: 20617 - Posted: 02.26.2015
By Michelle Roberts Health editor, BBC News online Scientists have proposed a new idea for detecting brain conditions including Alzheimer's - a skin test. Their work, which is at an early stage, found the same abnormal proteins that accumulate in the brain in such disorders can also be found in skin. Early diagnosis is key to preventing the loss of brain tissue in dementia, which can go undetected for years. But experts said even more advanced tests, including ones of spinal fluid, were still not ready for clinic. If they were, then doctors could treatment at the earliest stages, before irreversible brain damage or mental decline has taken place. Brain biomarker Investigators have been hunting for suitable biomarkers in the body - molecules in blood or exhaled breath, for example, that can be measured to accurately and reliably signal if a disease or disorder is present. Dr Ildefonso Rodriguez-Leyva and colleagues from the University of San Luis Potosi, Mexico, believe skin is a good candidate for uncovering hidden brain disorders. Skin has the same origin as brain tissue in the developing embryo and might, therefore, be a good window to what's going on in the mind in later life - at least at a molecular level - they reasoned. Post-mortem studies of people with Parkinson's also reveal that the same protein deposits which occur in the brain with this condition also accumulate in the skin. To test if the same was true in life as after death, the researchers recruited 65 volunteers - 12 who were healthy controls and the remaining 53 who had either Parkinson's disease, Alzheimer's or another type of dementia. They took a small skin biopsy from behind the ear of each volunteer to test in their laboratory for any telltale signs of disease. Specifically, they looked for the presence of two proteins - tau and alpha-synuclein. © 2015 BBC.
Keyword: Alzheimers; Parkinsons
Link ID: 20612 - Posted: 02.25.2015
By JON PALFREMAN EUGENE, Ore. — FOUR years ago, I was told I had Parkinson's disease, a condition that affects about one million Americans. The disease is relentlessly progressive; often starting with a tremor in one limb on one side of the body, it spreads. The patient's muscles become more rigid, frequently leading to a stooped posture, and movements slow down and get smaller and less fluid. As the disease advances — usually over a number of years — the patient becomes more and more disabled, experiencing symptoms from constipation to sleep disorders to cognitive impairment. Can Parkinson's be slowed, stopped or even reversed? Can the disease be prevented before it starts, like polio and smallpox? More than at any time in history, success seems possible. Having sequenced the human genome, biomedical researchers have now set their sights on the ultimate frontier — the human brain. The formidable puzzle is to figure out how a three-pound lump of mostly fatty matter enables us to perform a seemingly endless number of tasks, like walking, seeing, hearing, smelling, tasting, touching, thinking, loving, hating, speaking and writing ... and why those awesome abilities break down with neurological disease. Many scientists view Parkinson's as a so-called pathfinder. If they can figure out what causes Parkinson's, it may open the door to understanding a host of other neurodegenerative diseases — and to making sense of an organ of incredible complexity. In Parkinson's, the circuitry in a tiny region of the brain called the basal ganglia becomes dysfunctional. Along with the cerebellum, the basal ganglia normally acts as a kind of adviser that helps people learn adaptive skills by classic conditioning — rewarding good results with dopamine bursts and punishing errors by withholding the chemical. Babies rely on the basal ganglia to learn how to deploy their muscles to reach, grab, babble and crawl, and later to accomplish many complex tasks without thinking. For example, when a tennis player practices a stroke over and over again, the basal ganglia circuitry both rewards and "learns" the correct sequence of activities to produce, say, a good backhand drive automatically. © 2015 The New York Times Company
Keyword: Parkinsons
Link ID: 20606 - Posted: 02.24.2015
By Sandra G. Boodman Catherine Cutter's voice was her livelihood. A professor of food science at Penn State University, the microbiologist routinely lectured to large classes about food safety in the meat and poultry industries. But in 2008, after Cutter's strong alto voice deteriorated into a raspy whisper, she feared her academic career might be over.How could she teach if her students could barely hear her? The classroom wasn't the only area of Cutter's life affected by her voicelessness. The mother of two teenagers, Cutter, now 52, recalls that she "couldn't yell — or even talk" to her kids and would have to knock on a wall or countertop to get their attention. Social situations became increasingly difficult as well, and going to a restaurant was a chore. Using the drive-through at her bank or dry cleaner was out of the question because she couldn't be heard. "I just retreated," said Cutter, who sought assistance from nearly two dozen specialists for her baffling condition. The remedies doctors prescribed — when they worked at all — resulted in improvement that was temporary at best. For two years Cutter searched in vain for help. It arrived in the form of a neurosurgeon she consulted for a second opinion about potentially risky surgery to correct a different condition. He suggested a disorder that had never been mentioned, a diagnosis that proved to be correct — and correctable. Until then, "everyone had been looking in the wrong place," Cutter said.
Keyword: Movement Disorders
Link ID: 20605 - Posted: 02.24.2015
By Gary Stix Everyone knows that ALS is a very bad disease, an awareness underscored by the recent Ice Bucket Challenge. The death of neurons that results in paralysis can be caused by specific genetic mutations. But in most cases, single genes are not the culprit. So researchers have looked for other risk factors that might play a role. Studies have tagged cigarette smoking as a definite danger. Alcohol, another plausible suspect, has yielded equivocal results in previous investigations. To get a better read on ethanol (some earlier studies were small), researchers from Sweden's Lund University looked at giant medical registries from that country, compiled at various times between 1973 and 2010. They found that individuals who were classified as problem drinkers were a little more than half as likely to be diagnosed with ALS as those who didn't have "alcohol use disorder." More than 420,000 problem drinkers were registered during the period surveyed—and there were 7965 patients who received an ALS diagnosis. The study, just reported in The European Journal of Neurology, controlled for gender, education and place of birth, among other factors. But it was unable to tell why drinking might help. It did lead, though, to a number of intriguing speculations. The researchers cited studies in rats, done by other groups, that indicated that ingestion of alcohol decreased the number of brain cells called astrocytes that bore high levels of a certain protein linked to the pathology of ALS. © 2015 Scientific American
Keyword: ALS-Lou Gehrig's Disease
; Glia
Link ID: 20562 - Posted: 02.07.2015
By Nick Lavars Keeping ourselves upright is something most of us shouldn't need to think a whole lot about, given we've been doing it almost our entire lives. But when it comes to dealing with more precarious terrain, like walking on ice or some sort of tight rope, you might think some pretty significant concentration is required. But researchers have found that even in our moments of great instability, our subconsciousness is largely responsible for keeping us from landing on our backsides. This is due to what scientists are describing as a mini-brain, a newly mapped bunch of neurons in the spinal cord which processes sensory information and could lead to new treatment for ailing motor skills and balance. "How the brain creates a sensory percept and turns it into an action is one of the central questions in neuroscience," says Martin Goulding, senior author of the research paper and professor at the Salk Institute. "Our work is offering a really robust view of neural pathways and processes that underlie the control of movement and how the body senses its environment. We're at the beginning of a real sea change in the field, which is tremendously exciting." The work of Goulding and his team focuses on how the body processes light touch, in particular the sensors in our feet that detect changes in the surface underfoot and trigger a reaction from the body. "Our study opens what was essentially a black box, as up until now we didn't know how these signals are encoded or processed in the spinal cord," says Goulding. "Moreover, it was unclear how this touch information was merged with other sensory information to control movement and posture."
Keyword: Movement Disorders
Link ID: 20561 - Posted: 02.07.2015
By Angelina Fanous After the height of the Ice Bucket Challenge last fall, I found myself at a dinner party where the conversation turned to A.L.S. — amyotrophic lateral sclerosis — the disease for which millions were dousing themselves to raise awareness and money. "Would you rather have A.L.S., Alzheimer's, or Parkinson's?" someone asked. All those diseases are devastating, but A.L.S. is unique in that it usually kills within two to three years of diagnosis. It was just a game to my friends, all of whom are in their 20s. Everyone chose A.L.S., agreeing that it would be the fastest and therefore easiest death. But I stayed silent. I hadn't yet told my friends that I had been diagnosed with A.L.S. in July — two months after my 29th birthday. Had I been healthy, I might have answered A.L.S., too. But since my diagnosis, all I have wanted is more time. When I first noticed I couldn't type with my left hand, the doctors narrowed down it down to two options: a treatable autoimmune disease or A.L.S. They initially began treating me for the autoimmune disease. About once a month, we shut down my immune system so it would stop attacking my central nervous system. But with no immune system I made regular visits to the E.R. "At least it's not A.L.S.," I consoled myself. When the treatment didn't work and the weakness spread to my left leg and right hand, A.L.S. was the only remaining possibility. Still, I did that socially acceptable but also borderline insane thing where I sought second, third and fourth opinions. I voluntarily subjected myself to excruciating medical tests. I got shocked with electricity, had my spinal fluid drained, and underwent a surgery to remove a piece of my muscles and nerves, all in the hopes of finding a different diagnosis. All of the tests confirmed the diagnosis of A.L.S. © 2015 The New York Times Company
Keyword: ALS-Lou Gehrig's Disease
Link ID: 20556 - Posted: 02.05.2015
by Bethany Brookshire The windup before the pitch. The take-away before the golf swing. When you learn to pitch a softball, swing a golf club or shoot a basketball, you learn that preparation is important. You also learn about follow-through — the upswing of the golf club or the bend in the elbow after a softball pitch. It's the preparation and the execution that get the ball across the plate, so why should we care about follow-through? In theory, once the ball has left your hands or sailed away from your club or racket, there's no movement you could make that could affect what happens next. So while some follow-through might be important to diffuse the energy you just put into your shot, it shouldn't really matter whether you swing your golf club up in an arc, whip it off to the side or club your opponent over the head with it. But follow-through is in fact quite important, and not just as an extension of the movements that preceded it. Consistent follow-through actually helps performance, reports neuroscientist Ian Howard and colleagues at the University of Plymouth in England. The finding gives coaches some science to back up their training, and helps scientists understand how the brain accesses motor memories. Howard has always been interested in how the brain learns movement tasks. "The first study we did looked at the preparation movement — you move backwards and then you move forwards [as in a golf swing]," he says. His lab found that the preparation before a particular motion had a strong effect on how our brains learn and recall motor movements. © Society for Science & the Public 2000 - 2015.
Keyword: Movement Disorders
Link ID: 20549 - Posted: 02.05.2015
By Lenny Bernstein Parkinson's Disease patients secretly treated with a placebo instead of their regular medication performed better when told they were receiving a more expensive version of the "drug," researchers reported Wednesday in an unprecedented study that involved real patients. The research shows that the well-documented "placebo effect" -- actual symptom relief brought about by a sham treatment or medication -- can be enhanced by adding information about cost, according to the lead author of the study. It is the first time that concept has been demonstrated using people with a real illness, in this case Parkinson's, a progressive neurological disease that has no cure, according to an expert not involved in the study. "The potentially large benefit of placebo, with or without price manipulations, is waiting to be untapped for patients with [Parkinson's Disease], as well as those with other neurologic and medical diseases," the authors wrote in a study published online Wednesday in the journal Neurology. But deceiving actual patients in a research study raised ethical questions about violating the trust involved in a doctor-patient relationship. Most studies in which researchers conceal their true aims or other information from subjects are conducted with healthy volunteers. This one was subjected to a lengthy review before it was allowed to proceed, and, in an editorial that accompanied the article, two other physicians wrote that "the authors do not mention whether there was any possible effect (reduction) on trust in doctors or on willingness to engage in future clinical research."
Keyword: Parkinsons; Pain & Touch
Link ID: 20542 - Posted: 02.02.2015
Ewen Callaway Since August 2014, more than 100 children and young adults in the United States have developed a mysterious paralysis. Many of them had fevers before losing strength in one or more limbs, and the cases coincided with a wider epidemic of a little-known respiratory pathogen. That virus, enterovirus D68 (EV-D68), is the leading candidate for the cause of the paralysis, which few children have recovered from. Yet researchers have not definitively linked the two, or determined how the virus could cause the children's symptoms. A study published on 28 January in The Lancet1 that describes a cluster of cases from Denver, Colorado, strengthens the link, but falls short of providing a 'smoking gun'. Here is what we know about the virus — and what scientists are trying to find out. It belongs to the enterovirus family, which includes poliovirus and the pathogens that cause common colds; it is most similar to the rhinoviruses that cause respiratory infections. Although EV-D68 was first isolated in the 1960s, it is relatively uncommon among enteroviruses circulating worldwide. However, since August 2014, the virus has been linked to more than 1,000 respiratory infections in the United States, some of them severe, and France has seen cases, too. John Watson, a medical epidemiologist at the US Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia, says that last year, EV-D68 was the predominant type of enterovirus circulating in the country. "That's a first," he says. Genome sequencing2 of viruses recovered from respiratory cases in St Louis, Missouri, shows that the EV-D68 strain circulating in the United States is most closely related to viruses that caused a pneumonia-like illness in three children in Thailand in 20113. What is the evidence that links EV-D68 to the cases of paralysis? © 2015 Nature Publishing Group
Keyword: Movement Disorders
Link ID: 20533 - Posted: 01.29.2015
By SAM ROBERTS When he was just 5 years old, Thomas Graboys declared that he intended to become a doctor. As a young physician, he visited a nephew serving in the Peace Corps in Mauritania and remained for two months, treating dozens of patients a day. He skied and played tennis and joined fellow cardiologists as the drummer in a rock band called the Dysrhythmics. In Boston, he was famous as a member of the team that diagnosed the Celtics star Reggie Lewis's heart defect before he died abruptly on a basketball court. In short, "he was a medical version of one of Tom Wolfe's masters of the universe," one reviewer concluded after Dr. Graboys (pronounced GRAY-boys) published his autobiography. But barely 60, after experiencing horrific nightmares, frequently flailing in bed, losing his memory, suffering tremors and finally collapsing on his wedding day, he acknowledged that he was suffering from Parkinson's disease and the onset of dementia. He informed his patients that he had no choice but to close his practice. "My face is often expressionless, though I still look younger than my 63 years," he recalled in the autobiography, "Life in the Balance: A Physician's Memoir of Life, Love, and Loss With Parkinson's Disease and Dementia," which was published in 2008. "I am stooped," he continued. "I shuffle when I walk, and my body trembles. My train of thought regularly runs off the rails. There is no sugarcoating Parkinson's. There is no silver lining here. There is anger, pain, and frustration at being victimized by a disease that can to some extent be managed but cannot be cured." After managing for more than a decade, Dr. Graboys died on Jan. 5 at his home in Chestnut Hill, Mass., his daughter, Penelope Graboys Blair, said. The cause was complications of Lewy Body Dementia, which was diagnosed after his Parkinson's. He was 70. © 2015 The New York Times Company
Keyword: Parkinsons
Link ID: 20485 - Posted: 01.15.2015
By Peter Holley "Lynchian," according to David Foster Wallace, "refers to a particular kind of irony where the very macabre and the very mundane combine in such a way as to reveal the former's perpetual containment within the latter." Perhaps no other word better describes the onetime fate of Martin Pistorius, a South African man who spent more than a decade trapped inside his own body involuntarily watching "Barney" reruns day after day. "I cannot even express to you how much I hated Barney," Martin told NPR during the first episode of a new program on human behavior, "Invisibilia." The rest of the world thought Pistorius was a vegetable, according to NPR. Doctors had told his family as much after he'd fallen into a mysterious coma as a healthy 12-year-old before emerging several years later completely paralyzed, unable to communicate with the outside world. The nightmarish condition, which can be caused by stroke or an overdose of medication, is known as "total locked-in syndrome," and it has no cure, according to the National Institute of Neurological Disorders and Stroke. In a first-person account for the Daily Mail, Pistorius described the period after he slipped into a coma: I was completely unresponsive. I was in a virtual coma but the doctors couldn't diagnose what had caused it. When he finally did awaken in the early 1990s, around the age of 14 or 15, Pistorius emerged in a dreary fog as his mind gradually rebooted itself.
Keyword: Movement Disorders; Consciousness
Link ID: 20484 - Posted: 01.14.2015
By CATHERINE SAINT LOUIS A nationwide outbreak of a respiratory virus last fall sent droves of children to emergency departments. The infections have now subsided, as researchers knew they would, but they have left behind a frightening mystery. Since August, 103 children in 34 states have had an unexplained, poliolike paralysis of an arm or leg. Each week, roughly three new cases of so-called acute flaccid myelitis are still reported to the Centers for Disease Control and Prevention. Is the virus, called enterovirus 68, really the culprit? Experts aren't certain: Unexplained cases of paralysis in children happen every year, but they are usually scattered and unrelated. After unusual clusters of A.F.M. appeared this fall, enterovirus 68 became the leading suspect, and now teams of researchers are racing to figure out how it could have led to such damage. "It's unsatisfying to have an illness and not know what caused it," said Dr. Samuel Dominguez, an epidemiologist and an infectious disease specialist at Children's Hospital Colorado, which has had the largest cluster of patients. For many families, the onset of persistent limb paralysis has been a bewildering experience. Roughly two thirds of the children with A.F.M. have reported some improvement, according to the C.D.C. About a third show none. Only one child has fully recovered. In August, Jack Wernick, a first grader in Kingsport, Tenn., developed a "crummy little cold," said his father, Dan Wernick, who works for a paper company. It seemed ordinary, until Jack complained that his right arm was heavy, his face began drooping and pain started shooting down his right leg. © 2015 The New York Times Company
Keyword: Movement Disorders
Link ID: 20477 - Posted: 01.13.2015
By James Gallagher Health editor, BBC News website An elastic implant that moves with the spinal cord can restore the ability to walk in paralysed rats, say scientists. Implants are an exciting field of research in spinal cord injury, but rigid designs damage surrounding tissue and ultimately fail. A team at Ecole Polytechnique Federale de Lausanne (EPFL) has developed flexible implants that work for months. It was described by experts as a "groundbreaking achievement of technology". The spinal cord is like a motorway with electrical signals rushing up and down it instead of cars. Injury to the spinal cord leads to paralysis when the electrical signals are stuck in a jam and can no longer get from the brain to the legs. The same group of researchers showed that chemically and electrically stimulating the spinal cord after injury meant rats could "sprint over ground, climb stairs and even pass obstacles". Rat walks up stairs Previous work by the same researchers But that required wired electrodes going directly to the spinal cord and was not a long-term option. Implants are the next step, but if they are inflexible they will rub, causing inflammation, and will not work properly. The latest innovation, described in the journal Science, is an implant that moves with the body and provides both chemical and electrical stimulation. When it was tested on paralysed rats, they moved again. One of the scientists, Prof Stephanie Lacour, told the BBC: "The implant is soft but also fully elastic to accommodate the movement of the nervous system. "The brain pulsates with blood so it moves a lot, the spinal cord expands and retracts many times a day, think about bending over to tie your shoelaces. "In terms of using the implant in people, it's not going to be tomorrow, we've developed dedicated materials which need approval, which will take time. © 2015 BBC.
Keyword: Regeneration
Link ID: 20465 - Posted: 01.10.2015


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Paris Fashion Week & Dior Homme Welcomes Azari & III
Last night, Toronto royalty Azari & III played Dior Homme Fall/Winter 2013-2014 show at the Club Haussmann in Paris. Dior Homme creative director Kris Van Assche rounded up his models and special guests including Chromeo, Woodkid and Theophilus London to celebrate the special unveiling. Check out event photos, HERE
Keep your peepers on lock for Azari & III's upcoming single "Indigo", out next week Jan 29th on Dim Mak Records.
1 Comment
Fashion and politics would really mean a lot for all of us and we are looking forward to be part of it now. Thanks much.
Thanks, white dinner jacket

subset: commoncrawl


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Find it Fast
4:30 PM - 5:30 PM Attendance Make-Up in A162
Due to Mrs. Benson by May 20 in A133.
Boswell vs Lake Dallas at Northwest. Friday May 6, 4:30 & 7:30. Saturday if necessary 2:30.
Click here to view our campus attendance rates for both students and teachers.
See all of the great opportunities available for your kids by viewing flyers electronically through our Peachjar system. Look for the Peachjar icon on our webpage to view flyers or to sign-up. Click title above for more information.
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Eagle Mountain-Saginaw ISD 2015-2016 Free & Reduced Meal Applications are available by clicking on the following link: http://emsisd.heartlandapps.com.
Paper applications are available in the Child Nutrition Office, located at 1200 Old Decatur Rd. Building #6 Fort Worth, TX 76179.


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One of the adages that has become a mantra of mine is that "you don't get a second chance to make a first impression." Portraying oneself in a professional, reasonable and polite way is really a minimum for creating an effective professional persona. During the summer months, many students are seeking out internships or requesting… Read More
Har Sinai VP Graduates From ACHARAI
Joseph DeMattos, president and CEO of the Health Facilities Administration of Maryland (HFAM) and first vice president of Har Sinai Congregation in Owings Mills, graduated from the ACHARAI Fellows Program at the Shoshana S. Cardin Leadership Institute in May. ACHARAI's mission is to enable community leaders to be more informed, thoughtful and effective in the… Read More
Komrad Is Health Professional of the Year
The National Alliance on Mental Illness, Metropolitan Baltimore recently bestowed Dr. Mark Komrad with the Frances J. Lentz Mental Health Professional of the Year Award. This award is given to a mental health professional who reaches beyond the requirements of his or her profession to improve the lives of consumers and their families. Dr. Komrad… Read More
Kernan Hospital Now UMD Facility
Kernan Orthopaedics and Rehabilitation Hospital will be known as the University of Maryland Rehabilitation & Orthopedic Institute, reflecting its growing prominence in innovative and collaborative research to advance patient care, strong ties to the University of Maryland and continued commitment to the highest-quality patient-focused care. The hospital specializes in advanced rehabilitation services and state-of-the-art technological… Read More
LifeBridge Names Marketing VP
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Winsky Named CEO
Renee M. Winsky was named Leadership Maryland's President and CEO. She will replace Nancy Minieri, who founded the organization in 1992 and announced in March that she will retire at the end of this year. Winsky, of Davidsonville, was previously the executive director of the Chesapeake Innovation Center, a technology business incubator in Annapolis.
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Rourke & Rosenberg, a Baltimore-based immigration law firm, announced Cynthia B. Rosenberg, a partner in the firm, has been elected chair of the Washington, DC-Maryland-Virginia Chapter of the American Immigration Lawyers Association (AILA-DC). Rosenberg, a native of Baltimore, has practiced immigration law for over 17 years, and previously worked for Piper & Marbury and Weinberg… Read More
YWGCRealty Earns Awards
Prudential Homesale YWGC Realty's Clarkview Road office was recently recognized by The Prudential Real Estate network with two awards. The office was ranked as the second most successful Prudential Real Estate office of its size (minimum of 76 agents) in the southern United States in total number of closed sales and the total amount of… Read More
CCBC Receives Financial Reporting Honor
The Community College of Baltimore County has received a certificate of achievement for excellence in financial reporting from the Government Finance Officers Association of the United States and Canada (GFOA) for its comprehensive annual financial report for the 15th consecutive year. The Certificate of Achievement is the highest form of recognition in the area of… Read More
OurCrowd Launches Tmura Initiative
OurCrowd, the leading equity crowd funding platform for accredited investors, announced that as part of its commitment to social responsibility, it will require its Israeli portfolio companies to commit a portion of their equity to Tmura – The Israeli Public Service Venture Fund. Tmura is a non-profit organization that enables early-stage companies to donate equity… Read More
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Although I did not call the number 866 609 8298, I believe it to be bona fide. This is my story: I started getting robocalled everyday from 877 587 5727 asking me to call the above # re my Citicard. I ignored it because I do not have a Citicard. Some of the posts claimed that they called the number and were told their Citicard was over 28 days late and some others said that Citibank processed smaller store credit cards. I checked and found out that my Citgo card was handled by Citibank, and yes, I was over 28 days late. My bill was due Oct 8 and I forgot all about it (oops). I received a statement dated Oct 12 saying "bad person you are late and we are charging you an exhorbitant late fee. You have until Nov 8 to pay the minimum due". The robocalls started Oct 14 which falls in line with the 28 days late claim. I made arrangements with my online banking company to pay them Nov 6 (yesterday). If I am correct, in about a week, the calls should stop.11/07/2014 7:40AM
Florida Resident
I received a call today on my cell phone from 1-877-587-5727 telling me to call 1-866-609-8298 when I called the # back I was asked for last 4 of my social security and my D/O/B when I aksed why I was hung up on. Later I called 1-877-587-5727 and found out this is a phone # used to call contact phone #'s for Citi Banks Commercial Deliquent Accounts-This is your answer.06/24/2014 7:32PM


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Thursday, May 30, 2013
21 Comments | Copyright: India-Forums.com / TellyBuzz
Miditech's popular real life crime series 'Shaitaan - a Criminal Mind ', currently on-air on Colors, is telecasting its special series on 'Women Criminals' this weekend- June 2nd and next weekend June 8th, 2013. Hosted by the popular TV actor Sharad Kelkar, the series will focus on the not so often seen or heard; cold, calculative women criminal masterminds.
On this announcement, Nikhil Alva, CEO Miditech said, "Shaitaan is a show that delves into the minds of the worst criminals the society has seen. Be it a man or a woman, when the mind takes its own turn all controls fail! This weekend and the next we are coming up with two shocking real life instances that involve the frightening criminal attempts by women. To help create some much needed awareness amongst its viewers we will soon be telecasting it in our upcoming special episodes this weekend."
Sharad Kelkar, TV Actor & the Show Host on his association with Shaitaan said, "Considering the increasing rate in crime, where there is no demarcation between male or female, it's our prime duty to keep our alert button on. My association with this show has made me extra alert about different verticals in my life. Shooting for this series was thrilling as well as shocking to know that the rise on women criminals is a new trend compared to several years ago when women took a more passive role in crime."
The story that will be showcased this weekend 2nd of June, portrays the journey of a girl, from her childhood trauma of physical abuse from her uncle had such a psychological impact on her that she ended up having complete distrust and hatred towards men. The revulsion loathed to such an extent that she took revenge from as many as she could by turning into a serial bride.
Following this would be another episode of a female crime story, which will be telecasted on Saturday, 8th of June wherein a spoiled daughter kills her father who decided to disown her from his wealth and property.
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Clan Macintosh Feels the Pain
By PETER H. LEWIS
Published: April 2, 1998
CUPERTINO, Calif.— Most people merely buy a computer. Apple Macintosh customers fall in love.
Some Mac owners love their computers so much that they tattoo the rainbow-stripe Apple logo into their skin, proclaiming a passion unsurpassed in consumerism except by certain riders of Harley-Davidson motorcycles. Even though Windows-based computers now outsell Macs by more than 20 to 1, when was the last time you saw people with ''Windows 95'' flags or ''Intel Inside'' logos pierced into their flesh with needles?
Recently, however, even Mac lovers have started to switch to the dark side, replacing their cherished Apples with computers that are less elegant and innovative but cheaper and more popular. And some who once extolled the Macintosh with religious fervor are now discovering that when friends and relatives ask them which computer they recommend, or even when they themselves ponder which computer to buy next, they hesitate, even though there was no hesitation before. And sometimes they betray their love.
And some think what was once unthinkable: the Macintosh, which Apple once called ''the computer for the rest of us,'' has become the Sony Betamax of the computer industry, a superior technology that won people's hearts but lost in the marketplace.
Bob LeVitus, also known as Dr. Macintosh, is the author of more than 20 books on the Macintosh and its major software applications. Even he is starting to wonder if history is about to repeat itself.
''You can deny the Sony Betamax analogy only so long,'' he said in an interview. ''There's still hope, but let's get real. I'm not sure that even the most rabid Mac fanatics can look you in the eye today and say, without reservations, that everyone ought to buy a Mac.''
One cannot compare Apples with, well, Sonys, but one can argue that there are eerie parallels between Betamax and the Macintosh.
Sony introduced the Betamax, the first consumer video cassette recorder, in 1975. It quickly developed a loyal consumer base. JVC of Japan came out with a rival, the incompatible VHS system, the next year, but Betamax was widely regarded as the superior technology. But JVC aggressively licensed the VHS system to other large electronics companies. While Sony continued to be first with new advances, like hi-fi recording, the VHS companies always caught up.
By 1977, VHS machines usually cost less than Betamax machines. Sony's share of the VCR marketplace fell swiftly. Video magazines began to note that software choices, in this case, prerecorded movies, were broader for VHS.
By 1987 Sony's market share had fallen below 5 percent. Sony threw in the towel and began making VHS video recorders in 1988. It repositioned the Betamax as a high-end technology for the niche markets of television and video production, where it remains popular.
Some in the computer industry say the Mac is tracing a similar path.
''It is a platform that is slowly sliding into oblivion,'' said Dave Tremblay, a former Apple executive who is now a senior industry analyst for Computer Intelligence, a market research firm in La Jolla, Calif. ''I don't think the company is in danger of disappearing, but it is getting harder and harder for it to be a legitimate competitor.''
According to Mr. Tremblay, Apple's share of the worldwide computer market, once as high as 12 percent, plummeted to 2.8 percent in 1997 and is in danger of drifting lower this year, even as the overall computer market continues to grow robustly. Other research companies project Apple's 1998 market share at 2 to slightly more than 4 percent.
''One thing Apple has traditionally had going for it is its loyal customer base, but even that is eroding,'' Mr. Tremblay said. ''We do an annual study of repurchases, where we ask customers if they would buy the same brand of computer again. Apple has historically had the highest repurchase loyalty. We did for the first time a midyear study last year, and Apple's loyalty fell off dramatically. People are moving off the platform. They were less likely to buy a Mac than users had ever been, which is serious.''
Of course, some loyalists point to the Macintosh's ease of use and large base -- 25 million users -- and say the Mac is still the best choice for home use. ''I would absolutely, with no hesitation, recommend a Macintosh for a friend who is going to buy a computer for the home,'' said Adam Engst, editor of the popular Macintosh electronic newsletter Tidbits. ''For a business, well, that's a different story. The reason I have trouble pushing the Mac on the business side is not so much whether I believe in the Mac, but more that I'm so stinking tired of Apple and the whole soap opera it has turned into.''
And there is no doubt that the company, based here in Cupertino, has been on a tear lately. It recently introduced the fastest personal computer available. It has refocused its efforts on building Macintosh computers, jettisoning the handheld Newton and other distractions. A reinvigorated sales and marketing strategy, including a new emphasis on Internet sales, is getting positive results.


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"Heritage and more Heritage" Maldon by Anne12
Maldon Travel Guide: 25 reviews and 53 photos
I was getting cabin fever and decided to take a drive. So with camera in the bag I headed to Maldon.
Maldon is a heritage town approx 140k's from Melbourne
Just the right distance for a Sunday drive.
When you enter Maldon you will feel like you have stepped back in time.
All the buildings in the Main and side streets are as they were many years ago.
There are some lovely old pubs offering meals, plus cafe's and restaurants.
Also plenty of shops you can do a little retail therapy:)
Maldon was orginally a Gold town. In 1853 Gold was found in the area and 20,000 miners arrived in the first month.
At the end of 1854 a lot of the miners left to head to others areas around Maldon where gold was being found.
In 1860 Deep quautz mining started and Maldon became on of the richest gold fields in the world.
Mining continued until 1926.
There are many diggings and mines that you can still walk around.
One of the main ones is the Carmen's Tunnel Gold Mine.
Now the town is more known for the anitique shops along the main street.
In 1965 the National Trust recognised Maldons unique buildings and in 1966 it declared
the town Victorias first *Notable Town*
The population is now around 1,500.
The town has a very strict building and town planning code, hence the ld world feel it has.
- Pros:A lovely town to walk and browse.
- Cons:Can't think of any
- In a nutshell:A good distance from Melbourne for a Sunday drive.
Reviews (15)
I am not sure what the culture is in this.' In a window there was this huge scarf rolled up, meters of wool knitted by... more travel advice
I haven't stayed in Maldon, I only live 30 minutes away! There are a number of Bed and Breakfast places to stay. These... more travel advice
These are recommended camping sites around Maldon, Castlemaine and surrounding areas. Castlemaine is approximately 15... more travel advice
There are a number of lovely old churches that you can take a look at. These were built in the 1800's. At the Tourist... more travel advice
Comments (9)
Hey Anne - great page on Maldon, I remember coming here for a camp in primary school. I remember they had a great lollie shop here! :D ~ Cassie
Lovely page Anne - I grew up near the town of Maldon in Essex, UK!
Great tips, Anne! I will have to see if Mark will take me to Maldon :D
So did you add a square or two to the scarf? Hope you are enjoying Theme Park Coast :)
Good updates :) We are headed to the GOR, Grampians, and Ballarat tomorrow :)
What a wonderful page Anne!! I would love it here!! My dad would have loved this place too - a gold panner from way back haha :o) Love it!! Cheers, Ann :o)
Very informative. ("fry"? Perhaps dry)
I haven't been to Maldon for years!!! Must go re-visit one day soon.
sounds like a great place Anne..I llove antique shops..they are my favourite!!!!
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text:
Conditions remain difficult at Royal County Down, as several big names will miss the cut and only a handful of players have beaten par.
Rory McIlroy showed signs of improvement during the second round of the Irish Open, but it wasn't enough to keep the tournament's host around for the weekend.
As if the degree of difficulty wasn't already high enough at Royal County Down, Shane Lowry played most of the second round at the Irish Open without the use of his putter.
Blustery conditions humbled many of the world's best at Royal County Down, but a three-time major champ was still able to move to the top of the standings.
Luke Donald missed out on qualifying for the next two majors last week, but he took a big step toward solidifying his summer schedule with a 1-under 70 at the Irish Open.


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This article was originally published in The Denver Post on Dec. 29, 2005.
The Blue Bear
Something big was bruin in downtown Denver in 2005. Area residents were reminded that some of the best public art is often whimsical - witness the 40-foot-tall blue bear staring into the 14th Street side of the Colorado Convention Center. Created by local sculptor and photographer Lawrence Argent, the piece was installed in June. It proved an instant hit.
Ellie Caulkins Opera House
Envisioned as a world-class concert hall with acoustics to match, this "ship in a bottle" venue inside the old Auditorium Theatre opened in September with an all-star gala. The $92 million "Ellie," whose namesake is a champion of Colorado opera, is one of the crown jewels of Denver's burgeoning cultural scene.
NBA comes to town
Between the celebrity sightings, product launches, chichi parties and nightclub bookings, the NBA All-Star Weekend in February made Denver feel more like Aspen. Only bigger, with less snow and (a few) more faces of color. The Mile High City hosted basketball's elite in style, despite the fact that hardly any local fans secured All-Star Game tickets.
Gonzo goodbye
Hunter S.
Local girl makes good
Early in the year, Denver native AnnaSophia Robb starred in the family charmer "Because of Winn-Dixie." Then in a completely different turn, Robb co-starred in one of the best and most bankable movies of 2005, "Charlie and the Chocolate Factory." In one year, Robb went from being a sweet kid struggling with her mother's abandonment to embodying the berry bratty Violet Beauregarde, whose gum-chewing ways get her in a sticky situation.
O moves to 4
"Oprah" will give KCNC-Channel 4 a boost when the syndicated show jumps from ABC's KMGH-Channel 7 in 2006. For now, "Oprah" continues to bury the competition in the ratings.
Ogden pulls up stakes
Roger Ogden, long the golden boy of local broadcasting who was frequently courted by faraway parent companies, finally took the bait. He left Denver's KUSA-Channel 9 for a job with Gannett Broadcasting based in suburban Washington, D.C. A move bearing Ogden's fingerprints was the year-end purchase of Denver's KTVD-Channel 20 by Gannett. Expect an extreme makeover.
Hola to radio outlets
Spanish-language radio made inroads in the Denver market, reflecting the national trend. There are now four outlets beaming along the Front Range. The newest addition is KGDQ in Colorado Springs, formerly KKCS 101.9-FM, which joins KXPK 96.5-FM, KMXA 1090-AM and KBNO 1280-AM. Minority radio also suffered a setback: at year's end, CBS Radio pulled the plug on KDJM 92.5-FM, switching its format from R&B to country.
Courage amid carnage
Katrina coverage proved that American broadcast journalists still had backbones, as a number of reporters exhibited anger and outrage at the government response to the disaster. Anderson Cooper, in particular, rode his emotions to a new CNN anchor job, unseating Aaron Brown.
Anchors away
Viewers could hear tectonic plates shifting as Tom Brokaw retired as NBC's anchor, Dan Rather resigned in the wake of "memogate" at CBS News, and Peter Jennings signed off on ABC News, telling viewers of his diagnosis of lung cancer months before succumbing to the disease. Finally, Ted Koppel left his ABC "Nightline" post to three understudies as the sharply focused interview show segued into a newsmagazine format.
Central Park as art
In February, artists Christo and Jeanne-Claude unveiled "The Gates," the vivid, 16-foot- high fabric panels that ambled along Central Park's pedestrian paths like a saffron river. Of local interest, the artistic duo said they hope next to tackle their long-planned "Over the River" project, which envisions draping miles of fabric over Colorado's Arkansas River.
Kanye vs. Bush
It wasn't long ago that rapper Kanye West, humbled by a highly publicized near-death experience, simply referred to himself as "The College Dropout." But West returned with a vengeance this year, first, by making an inflammatory, prime- time comment about the president's handling of Hurricane Katrina ("George Bush doesn't care about black people"), then by releasing a market-friendly album containing two of the year's biggest radio hits, "Diamonds from Sierra Leone" and "Gold Digger."
Goodbye, Richard Pryor
With unabashed language and painful observations, Richard Pryor smashed through entertainment industry barriers. Even though fans had watched his health deteriorate for years, Pryor's death still came as a shock. His work will affect up- and-coming comics, actors and musicians for years.
Colorado Symphony
Jeffrey Kahane took the helm of the Colorado Symphony Orchestra this year, filling the shoes of the internationally lauded Marin Alsop. But Ka-
hane has shown himself up to the task, not only with his skills at conducting and as a pianist, but also with his warm interaction with fans and would-be fans of classical music.
Ending is best "Revenge"
Before the fantasy franchise became a commonplace, there was "Star Wars." In May, director George Lucas ended his prequel trilogy with an installment worthy of the original 1977-1983 trilogy. "Star Wars: Episode III Revenge of the Sith" made intergalatic box office (at more than $380 million domestic, 2005's No.1). Granted, that's a force to be reckoned with. But what "Revenge" did best was pull back the cloak on Anakin Skywalker's transformation into the world's scariest mouth-breather in a tale deserving of its PG-13 rating (a first for the franchise) but equally honoring of the Greeks and their tragedies.
Film fest home-hunting
On the morning of opening night for the 28th Starz Denver International Film Festival, we discovered the festival's parent organization had pulled out of one of the most exciting projects for the revitalization of East Colfax Avenue. The Denver Film Society would not be part of the troika set to transform the Lowenstein Theatre into an indie mecca (Twist & Shout and the Tattered Cover Book Store are the other partners). No weeping, please. Outgoing DFS chairman Richard Turner let it be known opening night that the film society still wants to build a new home in Denver. The festival went on to have its best attended run yet.
Jacko's last stand
Michael Jackson was the music man of the year. In June, the King of Pop was acquitted of all charges after a child-molestation trial that lasted more than three months and created the biggest media circus since O.J. with celebrities such as Jay Leno and Macauley Culkin taking the stand in defense of Jackson's moral character. It didn't take long for Jackson to ditch his Neverland Valley Ranch digs in favor of his new home in Bahrain, where he is close with the royal family. Now he's working on a charity single for Hurricane Katrina victims and, according to recent reports, pondering a Jackson 5 reunion. "I Want You Back" indeed.
The Fray got its day
With pop hooks that go on forever, The Fray broke out of the Mile High City with a ferocity we hadn't seen in more than a decade. While their music resembles other radio-rock stars, the band blazed its own path into the unfamiliar world of major labels, fandom, booking agents and sold-out shows - amazingly keeping their approachable, good-guy demeanors along the way.
Foxx struts his stuff
Forget Jamie Foxx's 2005 Academy Award for best actor - his 2005 nomination for best supporting actor, too - and focus on his starring role in Kanye West's hot "Gold Digger" single. His brand- new record, too: "Unpredictable." Foxx has the R&B under control, especially with the help of producers Timbaland and Sean Garrett and collaborators West, Twista, The Game, Ludacris, Common and Snoop Dogg.
Shaking things up
Kent Thompson came to Denver from the Alabama Shakespeare Festival and as the Denver Center Theatre Company's first new artistic director in 21 years and immediately invigorated the Tony-winning resident theater company with new energy and funding sources. He launched an ambitious and varied first season, including an American classic ("All My Sons"), a venture into magical realism (José Cruz González's deeply moving "September Shoes") and his own production of the French comic farce "A Flea in Her Ear."
Post staff writers Ricardo Baca, Elana Ashanti Jefferson, Lisa Kennedy, John Moore, William Porter and Ed Smith contributed ot this report.


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We are looking for talented Android Software Developers to make Etsy mobile a delightful, fulfilling experience for everyone, on every device.4/21/2016 Brooklyn, NY Save This Job
Position: # 163-1351 Location: New York City Have what it takes to be a great DIRTTbag? We?re looking for the right individual to join our team and lead DIRTT?s business development efforts in New York City. DIRTT is revolutionizing the construction industry with custom4/21/2016 New York, NY Save This Job
EnergyHub is a dynamic software technology company that is seeking several Software Engineers to join our growing team in Brooklyn!4/21/2016 Brooklyn, NY Save This Job
The Acquisition Marketing Manager drives customer acquisition and program awareness of smart thermostats and other connected devices for grid reliability and energy efficiency programs.4/21/2016 Brooklyn, NY Save This Job
Tracking Code 20120210 Job Description Wall Street Systems is the market leader in treasury, central banking and FX trade processing solutions. Its functionally rich and scalable solutions are used by the world?s largest corporations and financial institutions to improve4/21/2016 New York, NY Save This Job
APPLY FOR THIS POSITION Department:Giant Media Location:New York # of openings:1 Description DEPARTMENT OVERVIEW Giant Media (a division of Adknowledge) is one of the fastest growing native advertising companies in the world. Our one-of-a kind native advertising platform has4/21/2016 New York, NY Save This Job
ocation: Rochester, New York Description The primary responsibility of the Enrollment and Financial Aid Consultant is to provide enrollment management consulting advice via written reports to clients based on a review of off-the-shelf materials, analysis of institutional data,4/21/2016 New York, NY Save This Job
Department:Executive Location:New York # of openings:1 Description DEPARTMENT OVERVIEW Adknowledge is a digital advertising technology company, specializing in helping demanding clients get a great ROI from their digital media spending, in a brand safe way, at scale. Our4/21/2016 New York, NY Save This Job
A Mission with a Business LRN?s mission is to inspire principled performance?to help people around the world do the right thing. For more than 20 years, LRN has helped leading global companies leverage online courses to inspire their workforces, reinforce expectations for4/21/2016 New York, NY Save This Job
Tracking Code 20120208 Job Description This is customer facing role for an experienced service analyst to join an established ASP and Managed Service (MS) venture within a major software house. The right candidate will be a key contact point for the Wallstreet Managed Service4/21/2016 New York, NY Save This Job
Tracking Code 20120209 Job Description Technical Consultant to provide support of customer and technical requirements for highly specialized financial systems and to provide software based solution to meet user requirements. The role also requires configuration of treasury front4/21/2016 New York, NY Save This Job
Etsy is seeking an experience leader in marketing analytics4/20/2016 Brooklyn, NY Save This Job
Pixability New York Who We Are: Online video is already the fastest-growing marketing channel online, and it?s expected to double in the next two years. Pixability was founded by experienced technology entrepreneurs to bring a data-driven, scientific approach to video marketing.4/20/2016 New York, NY Save This Job
Senior Product Designers lead design and UX for projects, and collaborate with Product, Engineering, and Design teams to deliver clean and consistent user experiences for our 40 million members.4/19/2016 Brooklyn, NY Save This Job
The Full Stack Software Engineer collaborates with a team to build engaging and effective shopping experiences for Etsy's community of buyers.4/19/2016 Brooklyn, NY Save This Job
New York City Twilio is looking for a Field Sales Representative to prospect and manage high value SIP Trunking prospects/customers. The candidate will own the fast growing SIP trunking business, and source new opportunities for a fundamentally better way to provide voice4/19/2016 New York, NY Save This Job
New York, NYFull-time Company Description WHAT IS SMAATO DOING? Smaato runs the world's largest independent mobile advertising platform for mobile app developers and publishers. Our platform helps mobile developers and publishers make money by placing advertising in their mobile4/19/2016 New York, NY Save This Job
As a Senior Product Manager, you'll develop and ship successful, meaningful products that help Etsy sellers succeed.4/19/2016 Brooklyn, NY Save This Job
As a QA Manager, you will be responsible for making sure all software releases follow an agile but thorough testing process that ensures a high quality of each release. You will be developing test scenarios - both for manual and automated testing - confir4/19/2016 New York, NY Save This Job
About Us: CrowdTwist is an industry-leading provider of comprehensive multichannel loyalty and analytics solutions that drive engagement and incremental spend, leading to better customer data, stronger insight, and more personalized experiences. We are revolutionizing loyalty,4/19/2016 New York, NY Save This Job


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Find The Algorithm for Love From OKCupid.com Founder Sam Yagan
* Additional fees apply. No coupon or promo codes necessary to enjoy the displayed discount price.
The last date listed for The Algorithm for Love was Thursday February 14, 2013 / 6:30pm.
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Oysters, Beer, Chromeo & More at San Francisco OysterFest
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Overall, a good event. However, The Commonwealth Club spent way too much time self-promoting and doing introductions. The female moderator who was "in conversation" with Sam Yagan was not memorable except for her annoying laugh. Sam Yagan though is one smart guy, and his ideas about online dating are intriguing. He stole the show: could tell a good story, handled himself well on-the-spot,and was very personable in a geeky, math major kind of way. Of course he won't give up their mysterious algorithms! But he did give some insight to the group as to what the data crunchers behind the scenes at his two dating site companies are doing. The complimentary cocktails and munchies offered by the Commonwealth Club after the talk were also nice.
About the Ticket Supplier: Commonwealth Club
The Commonwealth Club of California is the nation's oldest and largest public affairs forum, presenting over 400 annual events on topics ranging across politics, culture, society and the economy.
Founded in 1903, the Commonwealth Club has played host to a diverse and distinctive array of speakers, from Teddy Roosevelt in 1911 to Erin Brockovich in 2001. Along the way, Martin Luther King, Ronald Reagan, Bill Clinton and Bill Gates have all given landmark speeches at the Club.


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|Key Info
Set upon one of the most prestigious and sought after locations on the Golf Resort is this stunning 2BR second floor penthouse apartment. The apartment is situated on the second floor of a block of 4 apartments front-line to the 18th fairway/ green.The apartment consists of a large lounge/ diner separate fully kitchen four piece bathroom suite two double bedrooms with fully fitted wardrobes one large furnished terrace access by both bedrooms one & the lounge and one furnished totally overlooked private roof terrace. The apartment overlooks the 18th fairway/green and has sea, mountain and communal pool views.The property has been fully redecorated and refurnished recently and has flat screen TV with several English and international channels, DVD-player, internet, leather suite & dinning table with leather dinning chairs the private roof terrace has an outside shower & sun loungers for that all over tan! Ideal for families couples or even groups wanting to take advantage of the golf sun & sea.
It is just 150 meters from the Golf Club Fuerteventura Golf housed in a 5-star hotel with restaurant and cafe. From the hotel, it is also a free bus that goes down to the mall, the beach and into the city Caleta De Fuste. If you want to walk, it's about 1.5 km which takes about 20 minutes.
Recently installed internet, WiFi, in the apartment and if you are interested you can have access for a small fee.
|Sleeps up to 5, 2 bedrooms
|2 bedrooms, 1 bathrooms of which 1 family bathroom, Solarium or roof terrace
|Nearest beach
|Caleta De Fuste 1.3 km
|Will consider
|Long term lets (over 1 month)
|Car not necessary
|Nearest Amenities
|1.2 km
|Nearest travel links
|Nearest airport: Fuerteventura Airport 9 km
|Family friendly
|Great for children of all ages
|No pets allowed, No smoking at this property
|Internet access, DVD player, Sea view
|Shared outdoor pool (unheated), Children's pool
|TV, Safe, Satellite TV, Wi-Fi available
|Kettle, Toaster, Iron, Hair dryer
|Cooker, Microwave, Fridge, Freezer, Washing machine
|Double Beds (1), Single Beds (2), Dining seats for 6, Lounge seats for 6
|Linen provided, Towels provided, High chair available
|Shared outdoor pool (unheated), Balcony or terrace, BBQ
|Parking, Suitable for people with restricted mobility, Not suitable for wheelchair users
The region of Fuerteventura is ideally located approx 3 hours and 40 minutes flying time from London offering all year round sun and stunning white sandy beaches to rival the Caribbean which incidentally is located approx 9 hours flying time from UK! With Ryanair currently flying direct from Dublin and Liverpool and from East Midlands, Birmingham and Stansted. The climate is excellent for golf and water sports and its rugged terrain offers some spectacular walking experiences. The resort of Calete de Fuste is approx 10 mins transfer time from the airport the resort is fronted by a white sandy horse shoe bay & marina the resort offers 2 golf courses (Spanish open 2004) 4 and 5* luxury hotels including the Sheraton and Grand Lux Elba Palace Hotel many restaurants & bars & Atlantico commercial centre plays host to ten pin bowling 10 screen cinema outside play area for children & many designer outlets all of this is within easy walking distance.
Golf: Two very nice golf courses situated in the immediate vicinity of the apartment approximately 10 min apart. Fuerteventura Golf is just outside the apartment overlooking the 18 hole fairway. The course is a typical park course and hosted the Spanish Open in 2004. It´s a varied championship course with challenging holes. The clubhouse is a part of the 5 star hotel Elba Palace there you can eat lunch/ dinner or maybe only have a nice cup of coffee. Both courses are really flat but if you need to hire a buggy it´s not a problem. Both courses have buggies, electric trolleys and really good golf equipment fore hire. Salinas Golf course is a little bit shorter and more like an open links course with strategic challenging holes. We can recommend to stay and enjoy the food in the clubhouse of Salinas. They have been awarded fore their good and flavour food.
All year round Sunshine, with over 150 beaches! See the picturesque sandy beaches of Morro Jable & Jandia, and the protected sand dunes of Corralejo and newly opened waterpark. The island also has a zoo, with live shows and you can visit the beautiful adjoining cactus gardens. See the Historic village of Betancuria, or visit the salt museum.
From the apartment it is a 3 minute walk onto the 1st tee of Fueteventura Golf Club ( venue of the Spanish Open 2004) and the recently opened (2007) Las Salinas 18 hole course is situated alongside it. A 15 minute walk takes you to the "Atlantico" centre, where you will find absolutely everything you may require for your stay. In 2008 a beautiful man made beach was created just infront of te centre.Only a 25 minute walk into the centre of Caleta de Fuste, with Watersports, Oceanarium and a large choice of International cuisines. It's only a 20 minute drive to the Capital, Puerto Rosario where there is a superb shopping centre which opened in 2006. You can also visit the Salt museum, which is 20 minutes from the apartment.
The apartment is ideally situated for exploring the Island, being midway between the North & the South.
Caleta De Fuste is an ideal location for those looking for it all in a sunshine break. The beaches are world renowned and are never too busy. It has a wide sandy beach, perfect for children. The town boasts a picturesque marina with various excursions and water sports.


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The Village Theatre's 12th Annual Festival of New Musicals will take place Aug. 10-12, 2012, in Issaquah.
The Village Theatre's 12th Annual Festival of New Musicals will take place Aug. 10-12 in Issaquah. This year's in-process musicals will receive fully sung, low-tech performances.
One show, "Lizzie Borden," will be open to the general public; the others will be open only to Village Originals members (memberships start at $75) and invited guests.
Numerous musicals in past festivals have gone on to the company's mainstage ("Iron Curtain," next season's "Trails"), and some have reached Broadway ("Million Dollar Quartet"; "Next to Normal").
"Lizzie Borden" makes a rock musical out of the true saga of the New England woman who became a 19th-century celebrity after murdering her parents with an ax. Writers are Steven Cheslik-DeMeyer, Tim Maner and Alan Stevens Hewitt. (The show contains mature content, and parental discretion is advised.)
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The fest's other shows: "Hello Out There" by Eric Price and Frank Terry, is a coming of age musical about several youths who "take advantage of the newborn Internet to transform themselves into an unlikely trio of online stock advisors." "Oneida," by Beth Blatt and Daniel Green, is drawn from the true story of the 1848 Oneida Community in New York, an idealistic venture in community living.
"Great Wall," by Kevin Merritt and Kevin So, with David Henry Hwang, uses an R & B-influenced score to depict a young Asian-American pianist who overcomes bigotry and family pressures to seek pop music stardom. "The ToyMaker," by Bryan Putnam, concerns an American doll collector seeking out a European toy-maker whose village was destroyed by the Nazis in World War II. "Johnny Baseball" by Richard Dresser, Robert Reale and Willie Reale takes a new look at a famous baseball legend, the Curse of the Bambino, and entwines it with the 1920s story of a young white pitcher's love for a black jazz singer.
"Lizzie Borden," the only show open to the public, will be performed at the Village Theatre's First Stage, 120 Front St. N., Issaquah. Performances are 10 p.m. Aug. 10 and 5 p.m. Aug. 11 and 12. Tickets: $20-$25 (425-392-2202 or www.villagetheatre.org).


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Colorado Weather
Colo. weather warnings & watches
- Colorado Weather Forecast + Conditions
- Colorado Weather Alert Map
- Colorado Weather Radar
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Weather on Twitter
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March is known to offer Colorado residents a hodgepodge of weather conditions, and this weekend isn't any different.
Sunday's forecast calls for highs in the 60s in the metro Denver area, but snowfall for the high country.
The National Weather Service says this is typical for March, allowing outdoor enthusiasts to "enjoy deep powder at higher elevations west of the urban corridor and return back to springlike temperatures."
The normal high for early March is about 50 degrees, so Sunday will be unseasonably warm in the city.
Sunday's low for Denver and the eastern suburbs will be in the upper 20s. Western suburbs and Boulder will see a low of about 30 degrees, with a 10 pecent chance of snow after midnight.
The weather service said snowfall rates of up to a quarter-inch per hour will be common in the north-central mountains Sunday, with up to a half-inch per hour on high passes.
Colorado's ski resorts are thrilled that March has arrived.
"March is historically one the snowiest months in Colorado so we can't couldn't be more excited for it to be here," said Austyn Williams, a spokeswoman for Copper Mountain Resort.
Jeff Hanle, a spokesman for Aspen Skiing Co, described the weekend weather conditions as "fantastic."
"Beautiful warm springlike day today," he said. "And we're expecting 4 to 6 inches of snow tomorrow night."
The warmest temperature ever recorded in March was 84 degrees in 1971, according to the weather service. The coldest temperature was minus-11 degrees in 1886.
Andy Vuong : 303-954-1209, email@example.com or fb.com/byandyvuong


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Cooper Tire & Rubber Company To Announce Fourth Quarter/Full-Year 2013 Results
http://coopertire.com/Investors.aspx or at http://www.media-server.com/m/p/gjbhdo3i. Within two hours following the conference call, the webcast will be archived and available for 30 days at these websites.Questions may be directed to the Investor Relations Department at 419.424.4165 or by emailing firstname.lastname@example.com. About Cooper Tire & Rubber CompanyCooper Tire & Rubber Company (NYSE: CTB) is the parent company of a global family of companies that specialize in the design, manufacture, marketing, and sales of passenger car and light truck tires. Cooper has joint ventures, affiliates and subsidiaries that also specialize in medium truck, motorcycle and racing tires. Cooper's headquarters is in Findlay, Ohio, with manufacturing, sales, distribution, technical and design facilities within its family of companies located in 11 countries around the world. For more information on Cooper, visit www.coopertire.com, www.facebook.com/coopertire or www.twitter.com/coopertire.
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Kenneth Leighton (1929-1988): 'Crucifixus' - sacred works for choir & organ / Choir of Trinity College, Cambridge, Jeremy Cole, organ
1 CD / Hyperion / 2015-04-14Works: Kenneth Leighton: Magnificat & Nunc Dimittis (Magdalen Service); God's Grandeur, for chorus; Give Me the Wings of Faith, for soloists, chorus & organ; Missa Brevis for chorus, Op 50; Missa de Gloria,...
Performers: Cole, Jeremy; Kornas, Eleanor [Organ]; Vocal], Andrew Kennedy [Tenor
Conductors: Layton, Stephen
Ensemble: ; Trinity College Cambridge Choir
The choral music of Kenneth Leighton is beloved of cathedral and collegiate choirs across Britain. Immersion in the Anglican tradition dates back to the composer's...continue...
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Strauss: The Complete Songs Vol 3 / Kennedy, Vignoles
1 CD / Hyperion / 2008-05-13Works: Richard Strauss: Lieder (8), Op. 10; Lieder (8), Op. 49; Songs (6) for voice & piano, Op. 17 (TrV 149); Wozu noch, Mächden, soll es frommen, song for voice & piano, Op. 19/1 (TrV 152/1); Lieder ...
Performers: Vignoles, Roger [Piano]; Vocal], Andrew Kennedy [Tenor
This complete series of Strauss Lieder is fast becoming a worthy successor to the seminal Schubert and Schumann Lieder sets already recorded by Hyperion. Volume...continue...
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