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Trial record 6 of 20 for: PKU | Open Studies
Liver Cell Transplant for Phenylketonuria
This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2014 by University of Pittsburgh
University of Pittsburgh
Information provided by (Responsible Party):
University of Pittsburgh
ClinicalTrials.gov Identifier:
First received: October 20, 2011
Last updated: September 24, 2014
Last verified: September 2014
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Detailed Description:
The purpose of this research study is to determine whether partial irradiation of the liver and liver cell transplantation can reduce the need for dietary and medical management or could possibly eliminate the need for a special diet and medications to treat this disease for patients with phenylketonuria (PKU) by normalizing phenylalanine levels in the body. Phenylalanine (Phe) is a substance needed in the body that can only be obtained from the foods people eat. People with PKU cannot get rid of Phe in their body. Large amounts of Phe can cause problems, such as deterioration of mental function. At the present time, liver cell transplants are experimental and have been done in only a limited number of human subjects.
Radiation: Preparative Radiation Therapy
Procedure: Hepatocyte Transplant
Drug: Immunosuppression
Other: Liver Evaluation
Behavioral: Psychological Assessment
Phase 1
Phase 2
|Study Type:
|Study Design:
|Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Hepatocyte Transplantation for Phenylketonuria
Resource links provided by NLM:
Genetics Home Reference related topics: N-acetylglutamate synthase deficiency argininosuccinic aciduria citrullinemia ornithine translocase deficiency phenylketonuria succinic semialdehyde dehydrogenase deficiency tetrahydrobiopterin deficiency
MedlinePlus related topics: Phenylketonuria
Genetic and Rare Diseases Information Center resources: Inborn Amino Acid Metabolism Disorder PhenylketonuriaU.S. FDA Resources
Further study details as provided by University of Pittsburgh:
Primary Outcome Measures:
- Improvement/reversal of characteristics of PKU [ Time Frame: 6 months post hepatocyte transplant ] [ Designated as safety issue: Yes ]Measured as a 50% decrease in Phe from baseline study level.
Secondary Outcome Measures:
- Engraftment of Hepatocytes [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]Liver biopsy samples may be obtained if a response is ascertained after 6 months. (The approach used, surgical vs percutaneous needle biopsy, will be determined by the clinical setting.)
- Engraftment of Hepatocytes [ Time Frame: up to one year ] [ Designated as safety issue: Yes ]Laboratory tests of hepatic function
|Estimated Enrollment:
|Study Start Date:
|December 2011
|Estimated Study Completion Date:
|December 2015
|Estimated Primary Completion Date:
|November 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Hepatocyte Transplantation
See Below.
Radiation: Preparative Radiation Therapy
Subjects will undergo CT-based simulation and treatment planning for radiation therapy. Once a suitable hepatocyte donor is found and the cell count and viability is acceptable for transplantation, patients will receive Intensity-Modulated Radiation Therapy (IMRT) in one fraction(10 Gy)to the right lobe of the liver (but not exceeding 50% of the liver mass).Procedure: Hepatocyte Transplant
Within a maximum of two days after hepatic irradiation,the right or main portal vein will be occluded transiently (60-90 min)to provide a compensatory mitotic signal to donor hepatocytes. Directly following this transient occlusion of the portal vein, donor hepatocytes will be transplanted into the irradiated portion of the recipient's liver. If at 6 months we see an improvement in PHE tolerance but not normalization (i.e. PHE levels from 6 mg/dl to 10 mg/dl) on an unrestricted PHE diet, we will recommend re-transplantation with a goal of complete correction of PKU. Subjects will be re-evaluated every 6 months for re-transplantation.Drug: Immunosuppression
Following transplantation, patients will be treated with conventional immune suppression, as is used following whole organ liver transplantation. Patients will be followed as routinely performed following organ transplantation and also followed as would normally be performed for their PKU.Other: Liver Evaluation
Prior to the hepatocyte transplant subjects will undergo a liver evaluation which is standard for all patients who have whole organ transplants at Children's Hospital of Pittsburgh of UPMC. The evaluation includes immunosuppression medication education, psychological assessment, bloodwork to assess blood count, blood and tissue type, blood chemistries, immune system function and certain infectious diseases and abdominal ultrasound to assess blood flow to the blood vessels in the liver.Behavioral: Psychological Assessment
Subjects may undergo a psychological assessment at least 6 months post-transplant which will include a semi-structure open ended interview as well as the Adaptive Behavior Assessment System-II assessment and Beck Depression Inventory. If subjects undergo these assessments, they will be compared to those obtained pre-transplant to determine whether an improvement is associated with the transplant procedure. In addition, if subjects are experiencing depression, they will be referred for further care.
Detailed Description:
Human phenylketonuria (PKU) results from phenylalanine hydroxylase (PAH) deficiency, and represents one of the most common and extensively studied single-gene Mendelian disorders in humans. Unfortunately, optimum clinical outcome demands lifelong dietary restriction through adherence to an unpalatable and expensive artificial diet. Challenges in maintaining traditional therapy lead to increasing phenylalanine (Phe) levels in patients as they approach adulthood with an incumbent severe burden of psychosocial and intellectual difficulties. The recent introduction of the new medication Sapropterin for treatment of PKU has improved Phe control and dietary tolerance in some patients, but at enormous cost to patients and insurers for the FDA designated orphan product. Thus, there is an unmet need for novel therapies to correct PKU. PAH is almost exclusively expressed in the liver in humans. The main objective of the current proposal is to determine the feasibility of hepatocyte transplantation to correct the biochemical (and ultimately, clinical) features of PKU.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Previous diagnosis of classical PKU (Phe >20 mg/dl) Phe level greater than 10 mg/dl in past 6 months or any measure of Phe >20 mg/dl in past 6 months.
- Psychological assessment in the past year
- I.Q. >70 as assessed by Wechsler Abbreviated Scale of Intelligence (2-subtest IQ)
- Must have careful dietary management for one month in PKU clinic.
Exclusion Criteria:
- No biopterin synthestase defects
- Subject has active malignancy.
- Subject has allergy to immune suppression medications that are required post transplant procedure for the prevention of rejection.
- Subject has sepsis, pneumonia, other active infection or secondary life-threatening organ dysfunction.
- Liver biopsies, not necessarily a consideration for organ transplantation, but a contraindication at this time to cell transplantation if significant fibrosis was identified, may be performed if there is clinical indication of liver disease. Significant liver fibrosis will be defined by the Ishak Staging, Stage 5: bridges with occasional nodules.
- Subject is pregnant or breastfeeding.
- Subject has positive HIV serostatus.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01465100
Please refer to this study by its ClinicalTrials.gov identifier: NCT01465100
|Contact: Rachel Sada, MS
|Contact: Maria Bond
|United States, Pennsylvania
|Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center
|Pittsburgh, Pennsylvania, United States, 15201
|Contact: Rachel E Sada, MS, CIP 412-692-7673 firstname.lastname@example.com
|Contact: Maria Bond 412-692-7133 firstname.lastname@example.com
|Principal Investigator: Ira J Fox, MD
|Sub-Investigator: Kyle Soltys, MD
|Sub-Investigator: George Mazariegos, MD
|Sub-Investigator: Rakesh Sindhi, MD
|Sub-Investigator: Geoffrey Bond, MD
|Sub-Investigator: Gerard Vockley, MD
|Sub-Investigator: Georgianne Arnold, MD
|Sub-Investigator: John Crowley, MD
|Sub-Investigator: Melvin Deutsch, MD
|Sub-Investigator: Ben Shneider, MD
|Sub-Investigator: Robert Squires, MD
|Sub-Investigator: Charles Fitz, MD
|Sub-Investigator: David Finegold, MD
|Sub-Investigator: Suneeta Madan-Kheterpal, MD
|Sub-Investigator: Robert Stough, MD
|Sub-Investigator: Diana Shellmer, PhD
|Children's Hospital of Pittsburgh of UPMC
|Pittsburgh, Pennsylvania, United States, 15201
|Contact: Rachel E Sada, MS 412-692-7673 firstname.lastname@example.com
|Contact: Maria Bond 412-692-7133 firstname.lastname@example.com
Sponsors and Collaborators
University of Pittsburgh
|Principal Investigator:
|Ira J Fox, MD
|University of Pittsburgh
More Information
Keywords provided by University of Pittsburgh:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on April 27, 2016
|Responsible Party:
|University of Pittsburgh
|ClinicalTrials.gov Identifier:
|NCT01465100 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 20, 2011
|Last Updated:
|September 24, 2014
|Health Authority:
|United States: Food and Drug Administration
United States: Institutional Review Board
Keywords provided by University of Pittsburgh:
Additional relevant MeSH terms:
Amino Acid Metabolism, Inborn Errors
Brain Diseases
Brain Diseases, Metabolic
Brain Diseases, Metabolic, Inborn
Central Nervous System Diseases
Genetic Diseases, Inborn
Metabolic Diseases
Metabolism, Inborn Errors
Nervous System Diseases
ClinicalTrials.gov processed this record on April 27, 2016


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Infographic: Year-End Charitable Giving Options
It's the end of the year and you may be thinking about donating to your favorite charity. These gifts help nonprofits and could reduce your tax burden.
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Remember that a bonus, like your earned income from the rest of the year, will likely be taxed by Uncle Sam.

subset: commoncrawl


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Did you know rotating among three or four pairs of sneakers reduces running injuries by 39%? It's true, finds a study published in Sports Medicine Research Laboratory in Luxembourg.
So we've spent the past 2 months logging miles and training in the season's newest kicks to find the shoes that'll make even the crankiest, most tough-to-appease feet happy to work out. Now all you have to do is lace up any of these 25 standout pairs and enjoy whatever it is that you love to do. (Next year, we promise: We'll include the guys, too!)
Look for these icons to find the right pair for you:


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I am 18weeks 3d. I have gained 8 pounds since begining. Can you believe it..
Baby only weighs arounf 7 ounce right now. It is all on me :((
I have been eating too much ... I wonder how all of you are doing?
Never argue with an idiot. They will only bring you down to their level and beat you with experience.
Ava became a big sister.. Elliana 7.31.15 at 34+2
I'm 18wks today & I weigh myself weekly...I've gained 5lbs so far.
Mommy (33) + Daddy (35)...est. April 2006/married July 2010
DD (1) - May 2013
DD (2) - November 2014
I am 16w5d and have gained 8 lbs...I am on bedrest which is suppose to predispose you to weight loss from lack of appetite...not this girl. I am a FTM and am not sure what to expect as I was just told I have at least another four weeks of bedrest until my next OB doctor's apt.
Samantha-Mom to twins born @ 30 weeks Alexa and Jade (our angel) 11/02/2005 and Brecken @ 37 weeks 04/24/2013
Owner of Blue Layne Boutique
WHJ and MEC EST 04-03-09 D4L. Baby girl due 05-10-13. ♥
17 weeks & 10lbs
Me(31) ♥ DH(31) since 11/17/2001
Mom to Austin ♥(13) Madison♥ (6) ^i^Jaxon^i^ born sleeping 12/28/12♥ RAINBOW Kadyn Rayne 4/2/14♥


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The Telltale Bagel
The secret moral hierarchy of the New York Post.
It was the "$177 Bagel" that did it, finally solved for me the mystery of how the New York Post remains the nation's iconic daily tabloid in a media realm overrun by celebrification.
Despite not being a celeb or a serial killer, the $177 bagel was the subject of a Post cover on Feb. 10, the day a blizzard hit New York City. Instead of going with some conventional "Snowpocalypse" headline, the Post front page was dominated by terrorism-size type about the bagel, complete with a color photo of … a bagel. True, not the bagel, the long-digested original, but a stunt bagel, you might say, a stuffed half-bagel sandwich that was meant to represent the offending breakfast item. Or, to be precise, the breakfast item of the offender.
I've long been a humble student of the tabloid art. I once did a story on the legendary New York Daily News homicide guy, the late Pat Doyle (nickname: "The Inspector" because he supposedly let his crime-scene sources assume he was a cop). Doyle boasted he'd covered 15,000 homicides. In another piece for Harpers in 1983 (subscription required, I'm afraid), I compared the Post's focus on crimes of passion to our founding fathers' concerns about the dangers "the passions" posed to democratic rule, as discussed in The Federalist Papers.(I probably don't need to add that the founder of the Post was founding father Alexander Hamilton. Coincidence? I guess.)
And, terminal English major that I am, I have always thought that all great literature is founded on a tabloid template. Anna Karenina:
And now, as tabloids are ascendant—the National Enquirer, after all, has just convinced the Pulitzer committee to consider its work on the John Edwards affair for the highest prize in journalism—the Post's bagel has arrived to help me attain true clarity on what its particular brand of tabloidism represents.
But, first, let's define our terms with more precision. One distinction that has been lost in the arguments over tabloid culture—and is key to what's remarkable about the Post—is the difference between "sensationalism" and what I'd call "celebrity-ism." Of course, there's considerable overlap. But I believe there are reasons to respect, or at least learn from, intense tabloid coverage of sensational true-crime stories while still reserving the right to feel contempt for celebrity-ism, cringe-making red-carpet reporting, and the publicity-industrial complex that feeds it.
I've long felt there are things to be learned from tabloid stories that one does not learn from the "serious" journalism favored by elitists and J-school prudes. It's true that there is a campy, somewhat condescending relish for Post headlines among some serious journalists, but behind that there often lies a sneer at the subject matter of the paper itself. I've encountered it at the three J-schools where I've taught. And consider this characterization from the comments section of Nytpicker.com, the erudite Times-watching blog, published after a Times hire from the Post was caught plagiarizing: "[W]hy did the NYT hire from the NYP anyway? Are there not more reputable news orgs from which to hire? Jeez[.]"
But these sneers are not necessarily warranted. A tabloid focus on "sensationalist" stories can teach us more about human passions than any wonkish analysis of cap-and-trade amendments.
Still, the bagel headline has deepened my understanding of and appreciation for the paper's continuing distinctive appeal in an age where almost all other tabs have succumbed to celebrification. The bagel was not your conventional celeb.
Under the main headline—
—was this subhed:
Ripped Off
'Hole' Lotta
Dough: Feds
It was not an earth-shaking story, not what you'd usually consider Post front-page material. The bagel photo was less alluring than the previous month's parade of Tiger Woods "gal pals."
But it helped me recognize the true mainstay of Post stories. It's not just that the paper focuses on human passions; it also focuses on the right humans. The secret source of its staying power is its emphasis on what I'll call MLNCBB: mid-level noncelebrity bad behavior, the kind of crime and punishment stories that fascinate precisely because they're committed not by the gods and goddess of the red carpet but by (relatively) ordinary human beings who suddenly do extraordinarily ill-advised things, up to and including murder. Crime stories, usually with some bizarre, out-of-the-box twist, ones with often hidden but nonetheless accessible moral and philosophical implications, are the meat and potatoes of the Post's stew.


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Review: The Deptford Trilogy: Fifth Business/The Manticore/World of Wonders (The Deptford Trilogy #1-3)User Review - Goodreads
What a great author Robertson Davies was. This is dense, meditative, intriguing and, often, downright funny. Riffs on the subject of the subjective, memory and point of view and is thoroughly entertaining at the same time. Not sure I've ever given five stars before. Read full review
Review: The Deptford Trilogy: Fifth Business/The Manticore/World of Wonders (The Deptford Trilogy #1-3)User Review - Goodreads
Required reading in CanLit course way back when. Painful Read full review
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Five finalists for art at East Side Library to present Thursday
Five Milwaukee artists will present their ideas for public art at the new East Branch of the Milwaukee Public Library Thursday evening. The finalists, selected based on their past work, include:
Laci Coppins is proposing curved glass panels printed with images that represent memories gathered from the neighborhood about library experiences. The panels would be installed on columns and animated through the use of augmented reality. »Read Full Blog Post(4)
UWM honors visual effects Oscar winner Jim Rygiel
Jim Rygiel's road to winning three Oscars started at the University of Wisconsin-Milwaukee, which the Kenosha native attended from 1973 to 1977.
In ceremonies Friday, Rygiel, who won a visual effects Oscar for each film in "The Lord of the Rings" trilogy, was given the UWM Chancellor Recognition Award for having "demonstrated excellence." Earlier in the day, Rygiel met with UWM film students. »Read Full Article
Florentine Opera begins new season with lush 'La Traviata'
Milwaukee's Florentine Opera Company raised the curtain on its 80th season Friday evening, ushering in the season with a grand production of Verdi's "La Traviata."
"Traviata" is the tragic tale of a dying courtesan willing to give up everything for love. She is convinced by her lover's father to end the romance, but he relents at seeing his son's pain over the loss. The lovers reunite shortly before her death. »Read Full Article
Soulstice goes time-traveling with 'Picasso at the Lapin Agile'
Paris, 1904. A 25-year-old German physicist walks into a bar, where he'll eventually be joined by a 23-year-old Spanish painter. Albert Einstein, meet Pablo Picasso, courtesy of Steve Martin's "Picasso at the Lapin Agile."
A huge hit at the Milwaukee Repertory Theater 14 years ago, "Picasso" is back, in a staging by Soulstice Theatre that opened Friday. »Read Full Article


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February 2013, TruckingInfo.com - Cover Story
By Oliver Patton
The highway law that took so much effort over the past five years is just six months old, but now it's time to start again. As the U.S. Department of Transportation still unpacks the two-year, $105 billion measure passed last summer, Congress and transportation interests are gathering to return, once more, unto the breach.
Tags: GAO, Highway Funding, Highway Trust Fund, MAP-21, White House, DOT, Congress, Infrastructure, Infrastructure Funding
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from CITGO, will answer your questions
The expert, Brian Fletcher from Eaton, will answer your questions
J.J. Keller Expands ELog Training for Drivers
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Easy Operating Kin-Sider, Kin-Slider


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One Thousand And One Illustrations by INstockeeWatch
©2012-2016 INstockee
Beatiful art work, congratulations!
Your illustrations are beautiful your colours are mavelous I JUST LOVE YOUR ART 你的画法很特别,我十分喜爱你的画
Wow, your artwork looks flawless! Long live Magi!
MAGI FOREVER. It doesn't matter how many times I look at your illustrations.. your MAGI illustrations are actually my most favorite of them all. However, you're just damn awesome INstockee. 它真的很美。只要保持在图纸上。 (Sorry my Chinese isn't that good but I'm practicing it.)
It looks amazing.
I love it
owo no words for how awesome this is!!!
This is awesome!
Nice!! I love the colours!
*3* !! So pretty


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Image: http://www.bonvivanttours.com/tour_description.html#woodinville
A half-day tour in which you get to tipple, and be chauffeured about the wineries of Woodinville. A guided, mini-tour with stops at a series of both better-known, and less known wineries, from Chateau Ste. Michelle to small, family owned operations. Lunch (which is not included in the fee) will take place at a winery or restaurant along the way.
Many dates available, including Sunday, February 24
11 a.m. - 4 p.m.
$65 + tax per person; ($59 + tax for four or more)
Pick-up/return at Jack Cellars
8016 15th Avenue N.E.
Seattle, WA 98115
(206) 437-1298


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April 30, 2016
State officials are investigating what they say is tons of contaminated dirt dumped next to wetlands in the east.
Officials with the State Division of Waste Management say that the dirt dumped just a few miles west of Trenton in Jones County contains jet fuel.
The State Division of Water Quality says trucks started dumping the contaminated dirt three or four weeks ago. Witnesses say truckloads of dirt came in and then workers smoothed it over.
Jones County Sheriff's officials say P and F Environmental from Whitakers trucked in the dirt. Officials believe the dirt came from New River Air Station in Onslow County.
Water quality officials say they received an anonymous phone call about the dirt, and then found a liquid sheen of jet fuel after a preliminary investigation.
The Army Corps of Engineers also spent the day Tuesday scouring the wetlands next to the dirt.
The landowner, an elderly woman, has been given 30 days to clean up the dirt.
P and F and New River did not return phone calls seeking information.
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Leahy frustrated over immigrationJune 20,2013MONTPELIER — Sen. Patrick Leahy, D-Vt., is expressing frustration at the slow pace of debate on the comprehensive immigration reform bill now before the U.S. Senate.
Leahy, who chairs the Senate Judiciary Committee, said more than 130 amendments have been filed to the bill. But he said that since debate began last week, the Senate has finished work on just one, with another handful set for consideration Tuesday.
Leahy blamed 15 opponents of the bill for trying to slow up the Senate process and prevent the measure from coming to a vote.
He issued a statement saying he does not believe those 15 senators should be able to prevent the 84 who want a vote on the bill to proceed.MORE IN Vermont NewsMONTPELIER Foreigners who had been banking on their development investments in Vermont to get... Full StoryMONTPELIER Gearing up for a planned Saturday adjournment, Vermont lawmakers on Thursday... Full StoryMONTPELIER Senate lawmakers gutted a bill intended to offer protections for landowners who want... Full Story
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Quite out of the blue, Kyon receives a phone call from his middle school classmate Nakagawa. Six months ago, he spotted Kyon walking with the most beautiful girl he'd ever seen and instantly fell in love! Now he wants Kyon's help conveying his feelings. But Nakagawa has no idea that the fair maiden who stole his heart is actually an otherworldly being...Nagato?! How will the stoic alien react to Nakagawa's affections?!
Genre: Comics & Graphic Novels
On Sale: November 22nd 2011


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I am now 11 days past my due date which I am okay with I am a little uncomfortable but I don't feel extremly uncomfortable (yet). I went in for an ultrasound today and the doctor said everything is looking good and to wait until my next appointment with my midwife to see how everything is going. The reason I feel kinda like I failed is because they think my baby will weigh around 9-9.5 lbs!! which is crazy to me I thought he would only be a little over 7 lbs because everyone tells me I don't look like I am 9 months pregnant! Has anyone else had to birth a bigger baby?? I am really worried about it. or has anyone else felt like this? I also feel like I have tried everything to induce labor naturally but nothing has worked!
Thank you


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Scarlett in Vivienne Westwood–Following up her lace-filled appearance at the Los Angeles premiere, Scarlett Johansson attended "Captain America: The Winter Doldier" premiere in London yesterday. The blonde actress looked red hot in a crimson colored dress from the fall 2014 collection from the Vivienne Westwood Red Label. Scarlett paired the look with shoes by Christian Louboutin and jewelry from Sonia Boyajian.
Her poor boobs…Lovely dress, but ouch!
She may not be showing signs of a bump yet, but her chest has gotten absolutely huge!


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Archived Story
Edwardsburg suffers splitPublished 9:45pm Thursday, April 19, 2012
A six-run seventh inning kept the Edwardsburg softball team from a sweep of visiting Elkhart Memorial Tuesday.
The Eddies led 4-2 heading into the top of the seventh inning, but could not maintain the lead as the Chargers rallied for an 8-4 victory.
Edwardsburg rebounded to take the nightcap, 4-1 in six innings.
In the opener, Kaley Frank and MacKenzie Creed both doubled for the Eddies.
Andrea LaPlace took the loss.
Jill Blough tossed a two-hitter for Edwardsburg in the second game.
Teryn Williams, LaPlace, Frank, Blough and Creed all singled. LaPlace, Frank and Blough also drove in a run.
First game
Memorial 000 200 6 – 8 9 0
Edwardsburg 200 020 0 – 4 11 1
Ali Iavagnilio (W); Andrea LaPlace (L)
2B: Paula Strausborger (EM), Lauren Strausborger (EM), Kara Summers (EM), Kaley Frank (E), MacKenzie Creed (E)
Second game
Memorial 100 000 – 1 2 2
Edwardsburg 301 000 – 4 5 2
Jill Blough (W); Paige Erwin (L)
Varsity record
Edwardsburg 7-3
Tags: Edwardsburg, High school softball


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It's not. The problem is due to the PRS-505: they use an old and limited version of Digital Editions.
FYI - I tried to read this on my Sony PRS-505 and when I open the epub version it gives me a page error and won't display the book. I believe that the epub may be corrupt.


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We are very sad to have to report that Fifty Shades of Grey has lost its Christian Grey. Universal Pictures has announced that Charlie Hunnam has dropped out stating "….given Hunnam's immersive TV schedule which is not allowing him to adequately prepare for the role.." A role, which we are sure is very difficult. Fans who were not too happy about Hunnman's casting will be thrilled depending on who is chosen next. As of yet there is no word of an updated cast list but hey, at least Dakota Johnson as Anastasia is staying put…for now.
More trouble for Bieber. The young singer is yet again been accused of assault, this time by a DJ's tour manager at a club in South Korea. According to reports Justin Bieber requested that the DJ, Michael Woods, play hip-hop music. When Woods refused he punched the tour manager, Alex Madden, in the face. Charming. The club, however, is saying that no punches were thrown so who knows.
The beautiful Lauren Conrad is engaged to her boyfriend of two-years William Tell. The former Hills star made the announcement through her website.
Thanks to audience reviews and positive word-of-mouth Gravity took a strong hold of the weekend box office for the second week running with $44.3 million, and Captain Phillips made a solid debut in second with $26 million. Cloudy with a Chance of Meatballs 2 dropped into third with $14.2 million, a result below the original movie at the same point (up until now the family flick had been significantly outdoing its predecessor). There were even worse results for Machete Kills in fourth and Runner, Runner in fifth. The Mel Gibson/Sofia Vergara action flick bombed with a $3.8 million debut and the Justin Timberlake/ Ben Affleck thriller went from a bad debut last week to a worse $3.7 million this week.


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A dispute over paying rent reportedly escalated to the point that one person may have started firing shots.
It happened shortly before 2:00 a.m. Sunday. A man called police saying two women tried to force their way into his apartment in order to get at a friend who was there.
He was reportedly able to keep them from getting into the apartment in spite of the fact that one of the woman, identified as Kalie Kerr, reportedly pointed a gun at him.
A short time later shots were fired in the parking lot outside the apartment. One of the bullets went into the apartment, but no injuries were reported.
The woman the two suspects were reportedly after in the apartment told police she sought refuge there after Kerr allegedly pointed a gun at her earlier during a dispute with both suspects about rent. The victim and Kerr are reportedly roommates.
Kalie Kerr was arrested and charged with felony menacing.
Police say they have identified the second suspect, but have not yet made an arrest.
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Academic Rigor
Dorm Life
Food and Dining
Bang for the buck
Clubs and Activities
Greek Life
Campus Safety
At the University of Maryland, you learn so much more than just facts and truths from textbooks and lectures. While the classes are extremely informational, and the professors and T.A.s are all very knowledgeable on their subjects, the real learning goes on outside of the classroom. Their are countless non-credit lectures, shows to attend, research teams to be a part of, professors to work with one-on-one, and relationships to be made which will help you mature into a worldly human being. I have grown up so much in the one year I have attended this school, and...
To find more tips for prospective students, what to do for fun and whether this school is great for a particular type of student read the 270 reviews for University of Maryland-College Park
Curious about something that isn't answered here? Feel free to ask University of Maryland-College Park a question
The campus is very big yet will feel small. The atmosphere is great. I really like it at UMD.Read More
Located only a few miles outside of Washington D.C., and home to one of the best academic programs in the world, UMD has something for everyone. Many people don't think of Maryland as a prestigious university, however nothing could be further from the truth. You will love every minute you spend on campus and will make your friends feel bad for looking down on such a great school.Read More
To get the grades you want, you're going to have to study. There are plenty of resources available to help with an endless amount of problems you have if you look for them. Some teachers are nice and fair, some are not.Read More
I love my school! The Terp Pride is strong and there is always a great turnout for sports events! I encourage every potential student to at least tour the school and decide for yourself!Read More
Now a senior at UMD, I have had such an indelible experience overall. I have made so many academic and sociable memories at the university; my experience has definitely been one for the books. University of Maryland College Park has changed and will continue to change my life, forever!Read More
The campus is very large and confusing for new students to walk, especially for those with handicaps. The buildings are high tech and very nice. Maryland would be good place to go for an education for many people.Read More
It's a wonderful school with such a big and gorgeous campus. The people their are friendly and very resourceful. If i had to pick a number one school this would be it.Read More
Very big, stadium is awesomeRead More
It's a great school. There's always something going on and there's such a variety of people you're sure to fit in somewhere. There's also so much school pride and it makes you really proud to be a terp.Read More


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Ankle sprains keeps Williams on sideline
LOS ANGELES - Its offense already struggling, USC might have to face Stanford without its leading receiver.
Junior Damian Williams missed practice Monday because of a high ankle sprain suffered against Arizona State that has him questionable for Saturday.
"I'm a quick healer, but I don't know," said Williams, who had a boot on his right foot. "I'm going to be smart about it, obviously. I'm not going to play if I can't because that won't do the team any good."
Williams leads USC in every receiving category with 45 catches, 688 yards and five touchdowns. No other Trojan has more than 17 receptions or two scores.
Williams also has a knack for coming through in the clutch, something USC needs more of from others to boost its ailing third-down percentage. The Trojans are 106th in the nation at 32.41 percent after converting only 6 of 27 the past two weeks.
"He makes tough plays, tough catches," USC coach Pete Carroll said. "(He) finds a way to make the play that's necessary."
If Williams is out, redshirt freshman Brice Butler likely would start opposite Ronald Johnson. With David Ausberry (leg) and Brandon Carswell (toe) also hurt, juniors Travon Patterson and Jordan Cameron are the top candidates for the No. 3 receiver spot.
Butler has 10 catches for 166 yards and a touchdown. Patterson and Cameron have one reception between them.
"Brice has done a really good job for a number of weeks here," Carroll said. "If he gets to play, I'm hoping he'll have a heck of a football game for us."
MAYBE McCOY
Williams' situation makes tight end Anthony McCoy's possible return even more essential.
McCoy, who has missed the past two games, ran in a straight line and jumped without any setbacks Monday. He said he still has some pain but expects it to dissipate by the end of the week. He will try to practice Tuesday or Wednesday.
Although replacements Blake Ayles and Rhett Ellison have struggled with drops, that isn't McCoy's motivation to come back.
"The season's almost over; that's my urgency trying to get back," said McCoy, a senior. "I've got three games left. ... I want to get back so I can finish my senior season."
McCoy leads the team with a 23.4-yard average per reception.
Defensive end Everson Griffen took some reps against the scout team and said he will play after missing the Arizona State game because of turf toe. ... Tailback Curtis McNeal did not practice because of sprained toe. ... Linebacker Chris Galippo missed practice because of a bruised and inflamed right knee but said he would return Tuesday. ... Safety Drew McAllister (hip) worked on the side.
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Zain logo exposed to a global audience tuned into Bahrain's motor racing event
- Hits on Zain corporate website soar 600%; social media engagements and viewers rocket
- Vodafone McLaren Mercedes F1 cars & team prominently branded Zain
- Brand promotional activities highlights the launch of 4G LTE in Bahrain
Kuwait City, Manama – 22 April, 2013
To further highlight Zain Bahrain's historic launch of superfast 4G LTE broadband services in the Kingdom, Zain took advantage of its Vodafone partner agreement, branding the Vodafone McLaren Mercedes racing cars and team distinctively with the Zain logo during the 'Formula 1 Gulf Air Bahrain Grand Prix'. This opportunity further enhanced Zain's global brand awareness as a worldwide audience viewed last Saturday's qualifying session and Sunday's race.
Notably for Zain Group, the company's digital presence received an astounding boost as the corporate website saw a 600% increase in average daily hits. Comparably, engagements and views on the company's social media channels – Facebook, Twitter and YouTube soared over a four-day period pre and post Sunday's race.
Zain Group's non-equity Partner Market Agreement with Vodafone Group that began in September 2012, entails Vodafone cooperating with Zain's operations in Kuwait, Bahrain, Iraq, Jordan and Saudi Arabia to provide customers enhanced telephony and marketing services. Zain is also the preferred partner of Vodafone in respect to the agreed areas of cooperation.
To mark Zain Bahrain's 4G LTE launch in the Kingdom, Zain also produced an entertaining TV commercial that featured 2009 world motor racing champion Jenson Button. The TVC was widely aired across the Middle East's main satellite channels, and was substantially viewed on YouTube. To view the TVC, please click here.
"The impact of the benefits of our partner agreement with Vodafone are immediate and enhance Zain on multiple commercial and marketing levels," commented Zain Group CEO, Scott Gegenheimer. "Launching 4G LTE technology in Bahrain was a momentous occasion in the history of the Kingdom as well as for Zain's customers who now benefit from a whole new realm of exciting high-speed digital content capabilities. It is befitting that the Zain brand was seen by a global audience during this prestigious motor racing event, and the association with speed, reliability and technical know-how was well made."
In the lead up to the motor racing event, both Vodafone McLaren Mercedes racing drivers, Jenson Button and Sergio Perez participated in a variety of promotional events to support and enhance the launch of 4G LTE services by Zain Bahrain.
About Zain
Zain is a leading telecommunications operator across the Middle East and North Africa providing mobile voice and data services to over 42.714 million active customers as of 31 December, 2012. With a commercial presence in 8 countries, Zain operates in the following countries: Bahrain, Iraq, Jordan, Kuwait, Saudi Arabia, Sudan and South Sudan. In Lebanon, the company manages 'touch' on behalf of the government. In Morocco, Zain has a 15.5% stake in Wana Telecom, now branded 'INWI', through a joint venture. Zain is listed on the Kuwait Stock Exchange (stock ticker: ZAIN).
For more information on Zain Group mobile operations across the region, please email: firstname.lastname@example.com or visit:


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Ideas That Generate Results
Convenience stores, as the name signifies, are retail stores conveniently located at gas stations, highways, or groceries and are generally open till late hours.
Our expert panel of research analysts with vast experience in retail industry intensely analyzes the convenience store industry and elaborately details on its various facets in our market research reports. We provide comprehensive information on convenience store statistics and present an inclusive picture on the convenience store industry.
We give qualitative and analytical research on the convenience store industry by region and provide pragmatic solutions to clients to help them meet their business goals.
Thailand Convenience Store Market Outlook
The rapid expansion of retailers and growing demand of convenience store, the number of convenience store in Thailand is growing at a CAGR o ...
Mar, 2016| Pages : 40 | Price : US$ 600.00
Asian Convenience Store Market Outlook 2020
By the end of 2020, the market size of Asian retail industry is expected to reach US$ 12.5 Trillion, growing at a CAGR of around 19.5% durin ...
Jul, 2015| Pages : 125 | Price : US$ 1600.00
Asian Convenience Store Market Outlook 2015
Retail industry of Vietnam, India, China, Indonesia and Hong Kong are growing at a rapid pace, providing ample opportunities for convenience ...
May, 2013| Pages : 95 | Price : US$ 1400.00
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The US c-stores market is anticipated to expand at a CAGR of around 11% during 2011-2014, driven by consumers increasing appetite for conve ...
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Asian Convenience Store Market Forecast to 2012
Asian c-store industry is heading fast towards the development phase, with c-store sales in Indonesia, China and South Korea expected to wit ...
Nov, 2011| Pages : 110 | Price : US$ 1200.00
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The US c-stores sales are expected to grow at a CAGR of around 11% during 2011- 2014, driven by economic rebound, convenience for shopping a ...
Jun, 2011| Pages : 65 | Price : US$ 800.00 400.00
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The countries like US, UK and Japan are expected to show positive trend in the C-store sales, with sales in the US to grow at a CAGR of over ...
Jun, 2010| Pages : 115 | Price : US$ 2000.00 1200.00
Asian Convenience Store Market Forecast to 2010
North Asia accounts for close to 90% of the Asian convenience store industry. Convenience store density is highest in Japan and Taiwan, with ...
Mar, 2009| Pages : 90 | Price : US$ 1000.00 500.00
Opportunities in Asian C-store Market
Concentration of modern retail trade in Asia is expected to account for 54% of the total retail industry by 2010. North Asia accounts for cl ...
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U.S. Convenience Stores: A Market Analysis
C-store unit growth continues to outpace population growth of the US as average number of persons per store has declined by 2.09% in 2006 fr ...
Feb, 2008| Pages : 55 | Price :


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Please read this PSA about AAI/AOI and the AAP's new guidelines:
We need to be aware!
Please read this PSA about AAI/AOI and the AAP's new guidelines:
We need to be aware!
Tara, mom of - Michaela 16, Elliana 13, Atalia 9, Benaiah 7, Zakkai 5, Simeon 4 (T21), Bogdan 3 (T21) & Keturah 2.
we had also just received some newer information about AAI - and the recomendation for an MRI - rather than an x-ray, if it is suspected.Lauren is 4 and has not had either but I am going to talk to her pediatricican about it when we see her this Friday.
Mom to Ada (28), Nolan(25),Gaven (12/29/01-3/14/2), Gabe (10), Lauren 7/22/07 DS
I saw this yesterday. It is scary. I have heard doctors say that the American Academy of Pediatrics is not recommending it anymore. It doesn't really make sense to me why they would say that. All the doctors I have heard still say that they should be checked around 4 years old, though.
step-mom to Justus and homeschooling mom to Madison, Austin, and Kamdyn T21, VSD, ASD, sleep apnea, reflux, laryngomalacia, light of my life! http://teal915.blogspot.com/
Thanks for sharing this important info. I think all parents of children with Ds should read this.
Melissa- married to David, lucky mom to 3 boys. Colter 5/11/00, Tavis 3/14/06, and Broden (T21) 7/16/09.
Thanks! Scary but important.
P (11/08) and M (4/25/11 T21, AVSD repaired 9/13/11)
EP'd for 9.5 months and done (with 5+ months frozen)!
It was a bit scary to read, but I do think we all need to be aware.
Tara, mom of - Michaela 16, Elliana 13, Atalia 9, Benaiah 7, Zakkai 5, Simeon 4 (T21), Bogdan 3 (T21) & Keturah 2.
Given that a 2-year old was mentioned in this - can they do the x-ray any sooner?
Can this be done by a chiropractor?
There is only one pretty child in the world, and every mother has it.
Angie, they can do the xray sooner...Ty just had one done and he's 17 months. I brought up the fact that he still has a slight head tilt to his doctor at the DS clinic in Boston a couple of weeks ago, and she ordered the xray to be safe. It took all of 5 minutes, and we had the results (negative) that night. I will probably request another one when he's older to be safe, but it's nice to know there's no evidence of it now. She brings up a lot of scary points though...I would definitely push for the xray, recommended or not!
Kerry, Mom to my one and only, Ty, born 3/10/10 (T21)!
I'll push for it now. I'd heard it was no big deal from the head of the DS association in Colorado. Yikes! Jakey goes in for his well baby check up next week and we'll definately get it scheduled. Thanks Tara!!
SAHM to Bella (7) Joseph (5) and Jacob (3 Down syndrome)
Follow my blog Light and Shadow at http://carolynm516.wordpress.com/


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Wealth and Power
An Economic Approach to Constitutions,
Parties, and Politics
To the period between 1912 and 1915 belong Beard's first great works in public law and American history: The Supreme Court and the Constitution (1912), An Economic Interpretation of the Constitution (1913), Contemporary American History (1914), and Economic Origins of Jeffersonian Democracy (1915). Written by a man ardently committed to bettering the conditions of life in a great city, these books reflect his belief that the future would "not be hideous and mean, but beautiful and magnificent" and his view of himself as a "co-worker in that great and indivisible natural process which draws down granite hills and upbuilds great nations." 1 These volumes certainly fixed Beard's reputation as an innovator among American historians and political scientists. Yet contemporaries who examined Beard's writing closely saw a disturbing problem: the "economic interpretation" did not exist as a unified theory of explanation. Beard shifted from an idea of people acting out of personal interest to a generalization that people represented the interests of groups. He approached an ideological interpretation of the actions of powerful groups and individuals, but he did not embrace it. Wealth and power were connected, and the public law reflected this connection, but his efforts to describe the process by which the law emerged from a social context were imprecise and contradictory.
In his well-known lecture "Politics," given at Columbia in 1908, Beard asserted that "the great question of any age" was "not shall private property as such be abolished," for the "nature of man" had demonstrated that "it


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Monday's Health Winners & Losers
(AGN - Get Report) and Mentor (MNT) saw their shares jump Monday after both won long battles to start selling silicone-gel breast implants for cosmetic purposes. Allergan was up 7.7% to $121.20, and Mentor was higher by 10.3% to $52.47.The Food and Drug Administration cleared the implants late Friday for women at least 22 years old, saying the "extensive body of scientific evidence provides reasonable assurance of the benefits and risks of these devices." Cyberonics (CYBX) said two top executives, including longtime CEO Robert "Skip" Cummins, have resigned from the company following a probe into past option grants. Investors were cheering the shakeup, and shares of Cyberonics, the maker of a device for treating depression, jumped 11.2% to $24. Leaving along with Cummins is Chief Financial Officer Pamela Westbrook. Reese Terry Jr., the company's co-founder, former CEO and a current director, has been named interim chief executive. George Parker III was appointed interim chief operating officer, and John Riccardi has been named interim CFO, effective immediately. Shares of CoTherix (CTRX) rose 19.5% to $13.38 after Swiss biotech company Actelion agreed to buy it for $420 million. The deal was unanimously approved by both companies' boards of directors. Actelion will make a cash tender offer of $13.50 for each CoTherix share, representing a 21% premium to the stock's closing price Friday. Anadys Pharmaceuticals (ANDS) was down 2.3% to $4.26 after it named Dr. Lawrence Fritz as its new president and chief executive. The appointment is part of a transition plan announced in June. Fritz will replace Dr. Kleanthis Xanthopoulos, who is also a co-founder of the cancer and antiviral drugmaker. Xanthopoulos, who has served as president and CEO since the company's inception in May 2000, will continue to serve as a member of the board of directors. The chief operating officer of drug developer SciClone Pharmaceuticals (SCLN - Get Report) has stepped down from his post, the company announced. Shares of SciClone lost 2.1% to $2.74. Alfred Rudolph, who joined the company in 1997, left last Friday. Friedhelm Blobel, the company's president and CEO, will take on the COO duties.Allergan
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It's a game that is vitally important to Eddie O'Sullivan and his management team as they go about the job of identifying the players who will eventually make the trip down under next year. And from a morale point of view this match is just as important as the side attempt to build on that success last week and bring their confidence level a notch higher. In all there are nine changes from the side that beat Australia as coach O'Sullivan gives players the opportunity to stake a claim to a RWC place. All over the field opportunity knocks, particularly at full back where Geordan Murphy will be hoping to nail down the number 15 spot but it's in the forwards where the fiercest competition for places will take place.
All that aside however, it's important that the team performance reflects the type of game O'Sullivan wants to perfect and individuals will have to sacrifice personal ambition for the overall good. It's a game Ireland should win but they should be aware that Fiji will be no push-over. They were well beaten last time out by Wales but will have benefited from that outing and will be strengthened by the inclusion of Waisale Serevi and Vili Satala. But Ireland still have loads of quality and although the Fijians will be delighted to see sunny skies and an end to the rain, this should prove a great occasion for record breaking David Humphreys who creates a new Irish record today for appearances at out-half
Ireland. G Murphy; S Horgan, B O'Driscoll capt, K Maggs, J Bishop; D Humphreys, G Easterby; M Horan, F Sheahan, J Hayes; L Cullen. M O'Kelly; A Quinlan, K Dawson, A Foley.Replacements: S Byrne, R Corrigan, M O'Driscoll, E Miller, P Stringer, R O'Gara, G D'Arcy, (Additional player - N Doak).
Fiji. Waisale Serevi (Stade Montois); Fero Lasagavibau


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Johnny Depp, Cameron Diaz, Mila Kunis strut their stuff in Sin City
Bevy of A-listers hit Las Vegas for CinemaCon 2012
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Dwayne 'The Rock' Johnson accepts CinemaCon's 'Action Star of the Decade' award
The ever-prestigious honor was presented by his "G.I. Joe: Retaliation" director Jon M. Chu and co-star Adrianne Palicki. Next stop: the Blockbuster Entertainment Awards! Wait, do they still have those?
Photo Credit: AP Photo/Chris Pizzello


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The Bauer Supreme TotalOne MX3 Youth Elbow Pads protect the future all-stars with an elbow pad designed specifically for youth hockey. Using a highly protective injected plastic elbow cap, the MX3 youth elbow pads manage just about any impacts a younger player can encounter on the rink. Its also flexible with a two-piece design, so their mobility won't be hindered.
The Bauer Supreme 150 Hockey Elbow Pads are the entry level model in the Supreme series. The 150's utilize medium density foams in the bicep guard and forearm guard for solid protection. The forearm is reinforced with a molded plastic insert to aid in slash protection.
The Bauer Prodigy 2-in-1 Shoulder-Elbow Hockey Top is designed specifically for youth players just starting to play the game. Bauer created the Prodigy lineup so youth players could easily slip into their gear while providing protection where they need it most.
The Bauer Vapor APX2 Elbow Pad is the flagship model coming from the Vapor lineup. These pads feature advanced Aerolite™ technology that reduces overall weight by 30% while maintaining key impact properties for pro-level protection.
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Four Selfless Things To Do Today
Most to-do lists detail tasks that need to be completed. By their nature, to-do lists are self-focused.
This is a different kind of list. Here are four things you should do today for other…
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text:
Flameball for RT by Akane-The-FoxWatch
©2012-2016 Akane-The-Fox
I like that position. Looks like she's dancing x)
another great piece, Akane! *pats you on the back*
Neopet lover and I love it
Sweet! Awesome job! I really love how you draw long, flowy hair! X3
Hehe, thanks! owo This guy certainly had the most hair I've ever drawn on a Neo character. XD;;; Probably up there with Izzy's curly do. owo
HE looks awesome Akane! Lol I could tell just because he's a little too flat for a girl. Love that hair!
Looks really great. Love the anatomy and the pose, very fluid. The coloring is a little abrasive, but it's great nevertheless!
Hehe, you did an awesome job as always! X3 He still looks very bright lol. XD
Hehe, thank you! OwO *wags tail and marks it off the list* One more down, two more to go! ^w^ *flops against and giggles* @w@
Dat random background. xD
The overall expression and the way the hair moves are fantastic~
Really great job, Akane. x3
The overall expression and the way the hair moves are fantastic~
Really great job, Akane. x3
LOL, thanks. XD I just kinda picked something random and ...'what' to throw back there. XD *giggles* It goes with his personality I suppose. owo
Hehe, and thanks again! XD *hugs*
Hehe, and thanks again! XD *hugs*
Hmm, you change a lot between how the faces look on your anthro Neopets. xD
LOL, of course I do! Each character has to have their own individual structure. ^^ Otherwise they would all blend together. owo
Nah, I mean like, some of them look more humanish, while others have a more distinct muzzle. Or it might have just been my imagination... bleh, tired. >_>
Ah, well, they are all different species so they all have different facial structures still. Aisha muzzles are a bit shorter so they kind of have more humanish faces when they get drawn up. No noticable muzzle markings or little black noses. XD;
He have double ears?
aww i really like the pose and expression alot there
the colors and the hair looks great too
amazing work
the colors and the hair looks great too
amazing work
LOL, yeah! XD; I was a little confused by all of that, but I suppose it was just all that awesome hair of his. OwO *wags tail*
Hehe, and you're welcome! XD I'm glad that you like him! owo *hugs*
Hehe, and you're welcome! XD I'm glad that you like him! owo *hugs*
Well, better late than never! xD
She looks great. <3
She looks great. <3
Male? Female? Femmale?
Best hair okay.
Best hair okay.
She came out too cute incredible job akane
He doesn't look as insane RT makes him. O_o although...


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text:
Hi people,
Another user here asked about adding a date image to a theme, I looked at a couple of examples and thought it would make a great twenty eleven child theme post.
So I have created a downloadable child theme for twenty eleven that has a date icon, although I have posted it as date image, the icon is pure css no images, so the gradient color can be changed easy.
I hope it is of use to someone.
Twenty Eleven Post Date Image


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A cop in Kansas City had a dance-off with a group of kids over the weekend. The officer has some pretty, um, interesting moves, and showed them off to the neighborhood teenagers. He told a local TV station: "When I joined the police force I told them I wanted to build a rapport with the community because I feel like if we build a rapport with them then they are more likely to call us when they need us." So he's building that rapport through bad dancing. And why not!
Holstein and Company Mornings
GOOD NEWS: Cop loses dance-off


text:
SHIPPINGover $50
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text:
This Kentucky Derby, You Can Control Johnny Weir's Outfit With Hashtag #WatchMeNeighNeigh
The first Saturday in May is nearly upon us and we all know what that means — another Kentucky Derby and another outlandishly stylish getup by onetime Olympian, current NBC Sports reporter Johnny Weir. Johnny and bestie Tara Lipinski, also of former figure skating glory, will once again lug their seven suitcases to Louisville to act as fashion and lifestyle experts for the network's coverage of the two-minute, 142-year-old pony show.
Though the majority of equestrian society will be sipping mint juleps decked out in antebellum designs, Johnny's outfit will be decidedly more modern, complete with a robotic brooch that gallops and lights up at your command. Yes, those of you with an unquenchable thirst for sartorial domination can tweet using the hashtag #WatchMeNeighNeigh (will that meme never die?) and it will be just as if you were trackside with Johnny and Tara, pulling on his lapel in the flesh. (more…)


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"It was well worth to upgrade to Pro version. Easy to put together. Works very nice." (E21375)
"very good would buy againg from epic and will recommend" (E8338)
"For the price I just couldn't resist. These thin needles get broken so easily that I hate paying retail for them. Well worth the small price even with the minimum purchase required" (E10946)
Epic Sports
Dickies Juniors Boot Cut Slim Fit Worker Pants [E93267]


text:
Clark, Michael (2005) Why Not Take a Cybernetic Approach to Sustainable Development? Planning and Environmental Management in North West England During the 1990s. In: Cities in Transition: Transforming the Global Built Environment. Open House Press, Altrincham, UK, pp. 118-132. ISBN 9780954446314
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|G Geography. Anthropology. Recreation > GF Human ecology. Anthropogeography
J Political Science > JS Local government Municipal government
T Technology > TD Environmental technology. Sanitary engineering
|College of Science and Technology > School of Engineering
|ID Code:
|Deposited By:
|Michael Clark
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Top Definition
someone who has lots of dollars but not enough to amount to real wealth.
I can't buy a house on Nantucket. I am only a dollaraire not a millionaire.
av leimberggreat 19. april 2010
Skriv din epost-adresse under og motta dagens Urban Word of the Day, gratis!
Alle eposter sendes fra firstname.lastname@example.com. Vi lover å ikke spamme.×


text:
useless coffee table books and outdated bestsellers. that's all that's in there.
more comics here [link]
more comics here [link]
Is there anything worth reading anymore? lol
Except for all those people who come in and want a "coffee table book" section.
Your store hasn't caved in and added a 'Pararomance' (Twilight, etc.) section yet then?
*lol* Those predate Twilight by so many years it's not even funny. Vampire romance was around for twenty or so years by the time I first became a fan in 1994 . As vampire romance goes, there are books so much better than Twilight to boot
This, oh so much awesome.
nothing wrong with history, i buy a number, though i am a history student and kinda need them
New age shlock, couldnt agree more with that!


text:
Temptalia Gives Away $195 in MAC Cosmetics!
If you've ever wanted to try MAC pigments or you just constantly fiend for more… this giveaway has you covered. All pigments and glitters are full-size products.
Winner will receive:
- Rushmetal Pigment
- Steel Blue Pigment
- Violet Pigment
- Golden Olive Pigment
- Kitschmas Pigment
- Blue Glitter
- Reflects Very Pink Glitter
- Refects Transparent Teal Glitter
- Reflects Rust Glitter
- Reflects Gold Glitter
Submit your entry by leaving a comment telling me what your favorite MAC pigment or glitter is.
RULES: All entries must be submitted by November 18th, 2009 at 11:59 PM PST. This contest is open to all readers as pursuant to your local state/country's laws. Winner will be chosen randomly and notified via e-mail. This post will be updated with "winner chosen" when one has been chosen.
Congratulations to Amy P., @helloxamyizzle, for winning!
Increase Your Chances to Win…
For a total of two chances! Just remember you must leave a comment on this post to get entered initially. Please be sure to use a valid e-mail address.
2. Follow us on Twitter (please include your Twitter name in your comment!) and re-tweet the following: RT @temptalia RT to win $195 in MAC Pigments&Glitters! Follow @temptalia! Rules: http://tinyurl.com/mac195pg


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Backside 24L Kitted Pack
Backcountry pack equipped with shovel and probe for all-day adventures
Backcountry pack equipped with shovel and probe for all-day adventures
When pushing the limits and seeking access into the backcountry the perfect pack can only get you so far. It's the goods inside the pack that matter too. K2 has designed a kitted pack that perfectly fits everything you need for a safe day in the backcountry. The 24- liter Backside pack comes complete with some of the best tools in the collection including the Rescue Shovel with the hoe mode and a 230cm Aluminum Probe. Since the pack was designed to accommodate these exact tools, you are not only getting a one-stop deal, but a system that works together for added comfort, style and ease of use. BackSide 24 pack helps you get out to the untracked with everything you need and none of the excess.
© K2 Sports 2016. All Rights Reserved.
Subscribe to K2 Skis email blasts to get the dirt on products, athletes, promos and events AND be automatically entered in monthly product giveaways!
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|Blackboard Downtime and Maintenance Schedule
Possible Blackboard Server Maintenance:
- The Blackboard hosting facility has a scheduled maintenance window every week from 11:00 pm Thursday to 4:00 am Friday Mountain Standard Time. This window will not be used unless maintenance is required. Notifications will be posted a week in advance if the maintenance window will be used.


text:
Vick, Eagles agree to 2-year deal
Updated: August 14, 2009, 11:39 AM ETESPN.com news services
PHILADELPHIA -- Michael Vick is back in the NFL. When he finally gets in a game, it might be at a new position.
Looking to add a new dimension to their offense, the Philadelphia Eagles gave the disgraced quarterback a one-year deal with an option for a second year. Vick wasn't brought in to compete with five-time Pro Bowl quarterback Donovan McNabb for a starting job, but the two could end up on the field together.
The first year of the deal is for $1.6 million with the second-year ...
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Quarterback Michael Vick has signed a two-year contract with the Eagles. Vick can take part in preseason practices, workouts and meetings and can play in the final two preseason games.
- Pro-Vick march might not happen Thursday
- Vick to make preseason debut Thursday
- Eagles, animal rights groups eye partnership
- Eagles teammates: Vick looks ready to go
- Dungy: 'You can't do that'
- Source: Vick to appear in court before game
- Vick continues workouts with assistants
- Vick likely to play Thursday
- No Philly event yet for Vick
- Sponsors sticking with Eagles
- Vick works out with Westbrook
- McNabb happy to share snaps with Vick
- Vick on '60 Minutes': I cried 'many nights'
- Vick puts in extra time after Eagles practice
- Sources: Vick gets $1.625 million regardless
- Vick practices for first time since prison
- Signing's reaction spans commerce, protest
- Vick embraces second chance
- Vick signs with Eagles | Blog
- Merrill: Philadelphians divided on Vick
- Mosley: Vick isn't worth all the drama
- Bryant: Vick's social debt is yet to be paid
- Chadiha: Vick's head in right place
- Graham: Eagles players embrace signing
- Mortensen: Philly adds up for Vick
- Clayton: Eagles a good fit for Vick
- Scouts Inc.: Vick adds Wildcat dimension
- Munson: Where Vick's Eagles money will fly
- Mosley: Eagles asking for trouble
- Bills' Edwards: 'We need him back'
- Fantasy: Vick a very deep sleeper
- Dungy: He can turn things around
- Eagles introduce Vick
- Mike and Mike debate signing
- Jaws, Gruden analysis of move
- Edwards: Another weapon for Eagles
- Reid: Vick deserves a second chance
- Paolantonio: 'State of shock'
- Mort, Young break down signing
- Merril Hoge analysis
- OTL: Examination of dogfighting today


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Regulatable genetic modifications of HESC for in vivo imaging and safety monitoring of implanted HESC: applications to neurodegeneration models
Human embryonic stem cells (HESC) can be differentiated into any cell of the body. This will allow HESC to be used to replace diseased or damaged cells. The brain is made up of mostly non-dividing cells; thus, upon brain cell death, there are no new cells that can take up the role of the diseased or damaged cells. HESC are thus of great importance for the future replacement of brain cells damaged in neurodegenerative disorders such as Parkinson's Disease (PD), Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), or multiple sclerosis. When sufficient brain cells have been killed by the disease process and no functional capabilities can be sustained, disease symptoms ensue. If cells in the substantia nigra die, patients develop PD; if cells from the basal forebrain and cerebral cortex die, they will develop AD, and if motor neurons from the anterior horn die, they will develop ALS. Fortunately, HESC can be differentiated into dopaminergic neurons (like those of the substantia nigra), cholinergic neurons and cortical neurons (such as those dying in AD), and into motor neurons (affected by ALS). Implantation of neurons of the right type into the diseased region of the brain could potentially overcome the severe symptoms of these diseases.
There are two challenges when HESC are implanted into diseased brains. One is to be able to track the implanted cells; i.e. are they staying within the implanted region, or are they moving away? Secondly, will HESC remain as differentiated cells, or will they form a tumor or teratoma. To address these issues we will develop two viral vectors, one derived from HIV and called a lentivirus (LV), and one derived from adenovirus, called a high-capacity adenovirus (HC-Ad). Both vectors have been engineered to remove their toxic and pathogenic genes, and are safe for use in animals and humans. The system will work in the following manner: LV will express genes in both non-dividing and dividing cells, while HC-Ad will sustain expression in non-dividing cells, but will be lost from dividing cells. HESC will be differentiated before implantation; to be of therapeutic use they should remain differentiated, and thus, non dividing. If they do, we will detect this as imaging signals originating from both vectors. However, it will be crucial to monitor in humans whether suddenly these cells start growing into a stem cell tumor, also known as teratoma. Should this happen, we will detect an increasing signal from the LV, but will lose the signal from the HC-Ad. Importantly the engineered HESC will have a gene encoded within their genome which will allow us to kill them should they become cancerous. In summary, we propose to develop a novel tool to track the location of implanted HESC in the brain, and their growth patterns. The system will be engineered to allow imaging in experimental animals and humans, thus, being a valuable translational tool as HESC move from the bench to therapies.
The promise of harnessing human embryonic stem cells for the treatment of human disease is being stimulated in great measure by the California Initiative in Regenerative Medicine. The graying of California's population is given by the fact that this is the most populous state in the Union, and thus, subjected to the progressive ageing of our population, as seen throughout the USA. In addition, due to its very favorable climate, California is increasingly attracting retirees to its midst. As a consequence it is highly likely that due to these demographic factors, California will experience a continued increase in the incidence of serious chronic neurodegenerative disorders.
Many of the diseases of old age sadly affect the structure and function of the brain. HESC's promise is to develop cells that will replace cells affected by these chronic, progressive diseases. Although sometimes diseases like Parkinson's, Alzheimer's or Lou Gehrig disease can affect patients in their late thirties or early forties, most of the patients affected by these diseases are 60 years of age or older. California's population is expected to increase by 172% by 2040, with the greatest growth being among those aged 85 and older. Their numbers are expected to grow by 200% by 2040. Thus, it is expected that by 2040 the ratio of the elderly to adults under age 65 will have increased by 80%! It is expected that by 2010 there will be close to 500,000 Californians with Alzheimer's alone, and could rise to 1,000,000 by 2040. Added to other chronic neurodegenerative diseases with increased incidence in the aged, new therapies are urgently needed.
The proposed application will develop unique novel tools and technologies to track the location and fate of implanted therapeutic HESC in the brains of affected patients. In addition, the novel tools will have safety elements that will allow to monitor whether implanted HESC become tumoral, and if so, to eliminate them. In summary, work proposed in this application will provide a strong platform for the development of effective and safe HESC-based therapies for devastating chronic brain diseases. Further, the HESC and the novel viral vectors to be used in this proposal have already been generated by our team in the State of California, thus, taking advantage of the intellectual and technological know-how developed in our State.


text:
The Unger Report: The Funder Guy
Listen to a 40-minute extended conversation between Frank Tavares and Day to Dayreporter Brian Unger.
Only Available in Archive Formats.
Day to Day investigative reporter Brian Unger gets an up-close and personal look at NPR's Frank Tavares — the guy who does those funding credits. Unger convinces Tavares to read the lyrics to "Welcome to the Jungle."
Related NPR Stories
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Badge Holder Kit contains reusable, clear vinyl holders with pins; white 8-1/2" x 11" microperforated sheets; and printer instructions. Permanently attached pin makes for easier and quicker use. Guarded pinpoint prevents snagging of clothing. Vinyl badges have three-way access. Badge goes on straight and stays straight during use. Insert sheets are compatible with laser and inkjet printers. 7 mil thick badge holders are side-loading.
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Become a member today and we'll send you our canvas High Line member tote as a special thank you gift!
As a member, you will be entitled to
Highliners sustain the park all year with monthly pledges. Give monthly, and join the circle of friends who are carrying the High Line forward.
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Join us for a free event on the High Line this season!
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Recordings and Transcripts now available
Mastering Time will help you develop right timing and use synchronicity to get in tune with the higher flow of time. You will discover why time seems to speed up or slow down and what you can do about it. You'll understand how time heals and how it reveals.
Plus, you will understand how to create your chosen future, the true role of prophecy, and how you can know whether a vision or intuition is a valid prophecy or even useful information.
8 Keys for Becoming a Practical Visionary:
How You Can Co-create the New World
Discover the unique part you can play in the New World now unfolding and how you can contribute your gifts and passion. We'll share practical exercises, meditations and experiential techniques to help you partner with the higher spiritual dimensions:
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STARmeterSEE RANK
Down 186,933 this week
Marguerite Hickey
Marguerite Hickey was born in 1963 in Rochester, New York, USA. She is an actress and producer, known for Santa Barbara (1984), Another World (1964) and Grizzly Mountain (1997). See full bio »
Born:in Rochester, New York, USA
More at IMDbPro » Represent Marguerite Hickey? Add or change photos


text:
The pros of using Facebook are coming dangerously close to being outweighed by the cons. Using the site can now get you fired, caught cheating on your spouse and cost you your identity. It can also apparently get the cops called to your underage kegger.
The post apparently had a list of its supplies which included: "two kegs of beer, vodka-jello shots and a 'Sexy Costume Contest.'"
Deputies say the Fluckiger Road bash drew some 300 people, which, considering that Toledo has a population of 653, makes it one of the most well-promoted parties in history.
Unfortunately, with 300 people sharing two kegs of beer, each person would have only got about one cup each, then been forced to fight over whatever jello shots remained. And we all know how ugly that can get.
KING 5 News posted a video on Monday, which includes one concerned old neighbor to the party who makes the self-defeating proclamation that she's "no fuddy-duddy."


text:
Recent Photo Albums
GCT Antwerp, Belgium
Mediteranean Equestrian Tour Oliva Nova, Spain
Enda's 30th Birthday, at Sentower Park, Belgium.
CSI** Drachten, the Netherlands.
Current time
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Recent news
CSI** Aachen, Germany
Last weekend, Marlon, Angelica, Stefanie and Dominic competed at CSI** Aachen, Germany.
GCT Antwerp, Belgium.
Angelica, Stefanie, Marlon and Dom competed at GCT Antwerp last weekend!
CSI*** Lummen, Belgium.
Wednesdy: 1.45: Spirit of Semilly and Marlon Modolo Zanotelli: 8th. Friday: 1.45LR: Extra Van ...
CSI** MET Oliva, Spain.
Wednesday: 7yr Olds: Marlon Modolo Zanotelli and Salt N Peppa: 1st. Thursday: 7yr old Final: Marlon ...
Visit Ashford Farm
Latest references
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I'm always on the look out for top young horses andI've always had luck at Ashford Farm, especially with my ...
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Markus and I have bought a number of top horses over the years at Ashford farm. We have never ...
Bertram Allen
"Our first purchase from Enda was a nice young horse called 'Barnike' who became the World Champion ...


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Designation helps ranchers and farmers obtain low-interest loans
A drought disaster declaration for Madera County has been issued by the California Emergency Management Agency (Cal EMA) and the US Department of Agriculture (USDA), officials announced Tuesday.
The county's designation as a primary disaster area makes low-interest loans available to local farmers and ranchers affected by the drought, Madera County Ag Commissioner Stevie McNeill told the Board of Supervisors at Tuesday's regular meeting.
The drought declaration, issued April 24, was based on the qualifying period of Feb. 26 through April 22, in which the USDA kept track of drought conditions in Madera County in a new streamlined disaster designation process called Drought Monitor, McNeill said.
"During that period many things are dormant, so we know that the people seeking low-interest loans and assistance for that drought period will be those dealing with pasture and rangeland for grazing for cattle," she said...


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Sunday Feb 03 2013
Fatalities reported in vehicle wreck on Auburn Folsom RoadBy: Staff
The California Highway Patrol is reporting fatalities from a vehicle accident that took place at approximately 7:39 p.m. Sunday when a white sport utility vehicle went off the roadway on Auburn Folsom Road near Shirland Tract Road.
The CHP closed a portion of Auburn Folsom Road at southbound Shirland Tract and northbound Taylor Street, according to the highway patrol. The roadway was later cleared at 10:12 p.m.
Check back to the Auburn Journal as more information becomes available.


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Bell & Howell 85mm F1.4
Started Mar 28, 2013 | Questions thread
Shop cameras & lenses ▾
Albert Drybrae • Contributing Member • Posts: 529
Bell & Howell 85mm F1.4
Does anyone have information about the Bell & Howell 85mm F1.4 lens? I might be able to get a good deal on this lens. I think it will be excellent for head and shoulders portraits. The F1.4 should make for nice out of focus backgrounds and since it's a fixed focal length it should be sharp where it is focused.
Anyone have knowledge abut this lens?
Albert Drybrae's gear list:Albert Drybrae's gear list
Canon EOS 7D Tamron 16-300mm F/3.5-6.3 Di II VC PZD Macro
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One of the great joys of life is creativity. Information goes in, gets shuffled about, and comes out in new and interesting ways.
Peter McWilliams
If you've checked out my "about me" page it tells a little bit about me and my family and how I've crafted for about 30 years. Today my eldest grandson created a necklace and he did a great job!
He created this Chicago Bulls necklace using the Perler beads. Great site for children to create all kinds of neat crafts.
He was so giddy about what he had made. Just to see that he wants to create makes me happy. We were all born to create and when God created he said "it was good".
I'm participating in the WordCount Blogathon so make sure to check back everyday this month for new content. Better yet, subscribe to my RSS feed.
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Thank you for visiting CynthiaBanessa.com, a place to create, inspire, and share! I love crafting and connecting with crafters. My blog is for crafters of all levels, Pinterest lovers, domestic engineers, savvy shoppers, aspiring chefs, earth caretakers, and people who simply have a desire to create something. I want to share some of the things that I love and have created with you. When it comes to creating, just count me in!
Latest posts by Cynthia (see all)
- Ceramic Coasters with Lettering - April 16, 2016


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I am tartin clomid tomorrow on day3 of my cycle. I'm kinda scared b/c I really hate meds. Been ROTC for 1 1/2 year though so I'm ready to do this. 27 years old and ready:)
Starting clomid, need buddy!
Posted 07/04/2012
Comments (5)
Posted 07/04/2012
I don't start till Saturday... If that is close if you wanna....hit me up firstname.lastname@example.com
AhhhAndrea · Original Poster
Posted 07/05/2012
I am starting 50. I am really scared, I have read that people have more pregnancies on 3-7 but also more miscarriages:/ I just want a baby! Thank you ladies! My email is email@example.com
Posted 07/05/2012
I'm in I start 50 mg days 3 - 7 tomorrow. Pryaing for BFP to all. This is my third round. I am doing OPK's and temping. Sending baby dust to all....
Posted 07/05/2012
Im in also-I start my 50mg of clomid tonight days 5-9 and im excited/nervous!! Im thinkin of doing OPk also but i really dont understand all of the rules that go along with it. And anyone doing clomid 1st time like me know any rules of thumb for takin it!!