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Printable Area
Photo by Mark A Freeman
Photo by Mark A Freeman
"These are really wonderful large, thick, and chewy cookies with a deep caramel flavour due to the unusual step of browning the butter . The recipe is from Cooks Illustrated Magazine (May/June 2009)."
Serving Size: 1 (1046 g)
Servings Per Recipe: 1


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|Hospital Quality
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10 Steps to Pick the Right Doctor
Whether you need a primary care doctor or a specialist, these 10 steps will ensure you find the right doctor for you. View Slideshow
Dr. Lee's Experience
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- Differential Diagnosis
- Diseases
- Drugs
- More
- Try building your search one term at a time, and be as specific as you can! Search term example: "chronic cough".
- Do not enter multiple findings such as "anemia, chronic cough, weight loss, vomiting" all at the same time.
- After selecting your term from the search results a list of possible diagnoses will be generated. If the list is too long, you will be able to narrow it down by entering additional terms.
- Do not enter values such as "heart rhythm 110" or "sodium 125", instead use "tachycardia" or "hyponatremia".
Sign-in (or register) to check out the new features we've just launched!
Differential Diagnosis For Residence/travel/Angola, Activity/Athlete games events/competition
Available only to registered users.
- Suggest
- 10 possible diagnoses found
- Trauma Causes
- Concussion
- Heart concussion/Commotio cordis
- Bone Bruise/Micro-infraction
- Electromagnetic, Physics, trauma, Radiation Causes
- Heat stroke
- Infectious Disorders (Specific Agent)
- Immune deficiency , acquired (AIDS/HIV)
- Congenital, Developmental Disorders
- Osteochondrosis, lunate bone (Kienbock)
- Osteochondrosis capitulum humeri, juven (Haas)
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Browsing Theses and Dissertations (MU) by Subject "African American children -- Education"
Now showing items 1-1 of 1
The psychology of the Negro (University of Missouri, 1914)The problems of race psychology have always been of absorbing interest. The existence of racial differences in intellect, morals and temperament is a matter of common observation among historians and anthropologists. It ...


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Reviews for
Number the Stars
Horn Book Guide Reviews 2015 Spring
This is a twenty-fifth anniversary edition of Lowry's 1990 Newbery Medal winning book about a ten-year-old Danish girl during World War II. A new introduction by the author reflects on the book's journey over the last quarter century.
School Library Journal Reviews 1997 September
The gripping story of a ten-year-old Danish girl and her family's courageous efforts to smuggle Jews out of their Nazi-occupied homeland to safety in Sweden. Readers are taken to the very heart of Annemarie's experience, and, through her eyes, come to understand the true meaning of bravery. (Mar. 1989) Copyright 1998 School Library Journal Reviews


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search the archive
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cultural studies and historical approaches
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journals and collections of essays
EXTENDED DEADLINE! CFP: Pedagogy: Teaching Video Games: SW/TX PCA/ACA (12/15/11; 2/8-11/12)
full name / name of organization:
contact email:
Seeking presentations for the "Pedagogy" section of the 2012 conference of the SW/TX PCA/ACA on the subject of teaching video games as primary texts. Many instructors have begun using videogames as teaching tools, but recent developments in video game theory allow for interpretation and analysis of these texts *as texts*, not merely as vehicles for tangential applications.
Possible topics for this session include but are not limited to: Strategies for teaching a particular game; Teaching gaming theory; Ludology and pedagogy; Convincing your department/institution to support gaming studies.
Please submit 300-word proposals as Word attachments to Shelley S. Rees at firstname.lastname@example.com by 15 December 2011.
Conference hotel:
For more details on the conference, including information about our areas of study, graduate student awards, conference travel, or touring Albuquerque and Santa Fe, please visit our website: www.swtxpca.org.
cfp categories:


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b noir Sep 16, 2012 4:46 PM
in response to mikeraydesign
Although you're getting slightly different symptoms, perhaps let's give the following user tip a try. (I haven't got the precise symptom set fully nailed down yet.)
iTunes for Windows 10.7.0.21: "iTunes has stopped working" error messages when playing videos, video podcasts, movies and TV shows
mikeraydesign Sep 16, 2012 6:02 PM
in response to b noir
Hi b noir,
No, sorry, that didn't work
When I click play it just freezes, right then and there. It doesn't give any indication that anything is loading, or anything. Here is an example of what I see: http://screencast.com/t/j2IEzzKh
As you can see audio plays fine, but not video. The same thing happens with video podcasts and even with movie trailers. This Movie in my library plays fine on my other computers and iPhone as well.
b noir Sep 16, 2012 6:07 PM
in response to mikeraydesign
Doublechecking. When you uninstalled iTunes, was it a complete uninstall/reinstall, as per the following document?
Removing and reinstalling iTunes, QuickTime, and other software components for Windows Vista or Windows 7
(Checking, because I think some of the video-playing-componentry is kept down in Apple Application Support nowadays ... if there's an issue with that stuff, just uninstalling and reinstalling iTunes on its own might not clear away the trouble.)
mikeraydesign Sep 16, 2012 10:34 PM
in response to b noir
Hi b noir,
I had not followed all those steps when you suggested it, but I have now; unfortunately, the result is still the same. I even uninstalled Safari and deleted by iTunes folder in my Music library.
bajatsa Sep 28, 2012 5:33 PM
in response to mikeraydesign
Hi mikeraydesign,
I started having the same problem several days ago possibly after installing the latest iTunes update. The problem is still not resolved completely, but I manage to get my videos playing. So here is what worked for me: I started iTunes in safe mode (which disables any third-party plug-ins, detailed how-to is here: http://support.apple.com/kb/TS3430 ) and tried to watch a random trailer in Apple store, it worked. Then I tried to start a rented movie and iTunes crashed. I started it over in safe mode again and watched the whole movie without a problem. However, the video still doesn't run if I start iTunes normally, so we need a solution for this. Well, better than nothing
mikeraydesign Sep 29, 2012 1:43 PM
in response to bajatsa
Hi Bajatsa,
Thanks for the reply...unfortunately for me this doesn't work, but I appreciate the thought!
psaul3 Oct 9, 2012 9:15 AM
in response to mikeraydesign
Update graphics card driver... or disable your default graphics driver. I was on the phone with Apple support on this same issue, they were not able to find any solution right now, but I did notice that when updating my video card driver, the issue was resolved
weedyT Oct 12, 2012 1:58 PM
in response to mikeraydesign
Same problem here - updated graphics driver and the first video I tried to play played audio only, then subsequent videos crashed again. *sigh* Anyone heard anything from Apple about fixing this bug?
raymondjohnson Oct 16, 2012 6:49 AM
in response to mikeraydesign
I had this same problem s a lot of others after updating to the latest I Tunes version. I finally got a decent response back from Apple, which was hard to do. Here is what they told me. Maybe it will help you:
I'm sorry to hear that you're dissatisfied with the way the episodes you purchased plays in iTunes on your computer. I appreciate your decision of contacting us to have this concern addressed. It's my pleasure to be of help for you today.
Raymond, please accept my sincere apologies for the inconvenience this issue has caused you. iTunes Store videos are optimized for playback on iOS devices and Apple TV.
This article often helps customers who are having video playback performance issues:
Troubleshooting iTunes for Windows Vista or Windows 7 video playback performance issues
If your computer meets the requirements yet video playback is not satisfactory, here are some things that might improve the quality:
1) Make sure you are using the latest version of iTunes for Windows. It is available free of charge here:
(Note that installing the latest version of iTunes will not affect your library or any items in your account waiting to be downloaded.)
2) Quit as many other open applications as you can before playing videos in iTunes.
3) Wait for all iTunes Store purchases to finish downloading before playing videos.
4) Use this article to guide you through updating your PC's drivers:
Updating the drivers on your Windows PC
5) Disable all non-Microsoft startup programs and services by following the steps in the appropriate article below:
Using Msconfig to troubleshoot conflicts in Windows Vista and Windows 7
6) If the video's audio track is not satisfactory, follow the troubleshooting steps in this article:
iTunes and QuickTime for Windows: Songs and other audio don't play correctly
weedyT Oct 16, 2012 8:29 AM
in response to raymondjohnson
Thanks, but sadly, no luck!
However - the same videos that won't play in iTunes WILL play in Quick Time. Not ideal, but it will work for now!
LarsFromGermany Dec 8, 2012 4:35 PM
in response to mikeraydesign
I can confirm this problem.
I have the exact same issue.
Uninstalling and reinstalling itunes/Quicktime didn't have any positive effect.
I can recreate the problem every time.
MistaBernie Dec 15, 2012 7:45 PM
in response to mikeraydesign
Same thing is happening to me right now. Bios, all drivers, etc are up to date, and I just built the system a couple of weeks ago. Happening with iTunes 11.01 and for any movie I have in my library.
Mikeycastellano Dec 28, 2012 9:06 PM
in response to mikeraydesign
Ive Been having the same exact problem the past few weeks, Everything updated ... i even went out and picked up an apple TV last week and it connects to itunes and plays music but the video just dosent play it just keeps buffering, witch pretty much makes this useless for me. Soooo now what? and this is the most up to date post that ive found that actually has ALL the same symptoms as me. Where do i sign up to fix this!
ascara Dec 30, 2012 9:56 AM
in response to mikeraydesign
And another one with the exact same problem. Just installed my PC yesterday. Everything is up to date. But no Video works...it just freezes :-(
I have tried everything that has been described here, but nothing worked. Really need HELP :-)
System components:
Inte Core i7 2,93GHz
64-Bit System
Graphic: NVIDIA GeForce GTS 240 (driverversion: 188.8.131.520)


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Upgradind USB 2.0 to USB 3.0 possible?
Started Jul 14, 2012 | Discussions thread
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prasanaphoto • Regular Member • Posts: 104
Upgradind USB 2.0 to USB 3.0 possible?
Hi friends,
I own a late 2008 unibody Macbook Pro 15in and iam looking at updaing to new MBP just for the USB 3.0 since my Nikon D800 supports USB 3.0.I shoot tethered and i guess USB 3.0 will be a good choice.One of my friend suggested that i can upgrade my existing system to USB 3.0 using the PC express slot.But is it advisable and effecient as built in USB 3.0 ?.Can something like this be done ?My system is out of warranty and my Nikon Camera Control pro trial version ends in 4 days.Thanks in advance
Nikon D800
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Another son of former Colorado Avalanche hockey great Patrick Roy is facing disciplinary action for his on-ice behavior.
Frederick Roy was suspended 15 games Monday by the Quebec Major Junior Hockey League for high-sticking during the Quebec Remparts' game against the Montreal Juniors last Friday.
Roy, a forward with the Remparts, struck Montreal defenseman Vincent Bourgeois in the mouth during a timeout.
The league decided to suspend Roy after reviewing video of the incident and interviewing those involved.
The suspension comes eight months after Roy's brother, Jonathan, was suspended for seven games by the junior hockey league for participating in on-ice fight.
Jonathan Roy, a goalie with the Remparts, attacked opposing goalie Bobby Nadeau during a game against the Chicoutimi Sagueneens. He is facing criminal charges.
Patrick Roy, the Remparts' coach, was suspended five games for apparently encouraging his son during that fight.
KKTV firmly believes in freedom of speech for all and we are happy to provide this forum for the community to share opinions and facts. We ask that commenters keep it clean, keep it truthful, stay on topic and be responsible. Comments left here do not necessarily represent the viewpoint of KKTV 11 News.
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The Center for Continuing Studies offers Traffic Safety Education courses to enable individuals to meet Driver Education Licensure requirements. Instruction is based upon requirements of the Minnesota board of teaching, rule, Rule 8710.4350 TEACHERS OF DRIVER AND TRAFFIC SAFETY. Applicants seeking driver Education Licensure must earn 13 credits to meet the most recent board of teaching requirements.
Traffic Safety Education courses are designed to sharpen skills and meet licensure requirements for those in driver education. These courses will help educators keep current affecting driver education programs.
Designed for busy teachers, professionals and students who might not be able to take on-campus classes, the program consists of five courses (four of the courses are online and one is an approved practicum). Course content of this 13 credit program is based on licensure requirements in the state of Minnesota .
St. Cloud State University is a fully accredited four year institution. The Driver Education Teacher Preparation program is accredited by the National Council for Accreditation of Teacher Education (NCATE) and the Council for the Accreditation of Educator Preparation (CAEP). Additionally the program meets the Minnesota Board of Teaching requirements and the teaching standards of effective practice.
All on-line TSE courses follow the Quality Matters (QM) format. The Quality Matters program provides professional development, a set of rubrics, and a course peer review process that work together to support faculty in improving the quality of online and blended courses. QM has received national recognition for its faculty-centered approach to continuous improvement in online education and student learning.
Students in other states must check with their own state for specific licensure requirements.
• K-12 school teachers who would like to obtain driver education licensure
• Undergraduate education majors who are interested in driver education licensure
• Commercial driving school employees
• Current licensed driver education instructors who want to update their knowledge and skills
• Supplement your income. Employment opportunities are increasing as many current driver education instructors are nearing retirement.
• Teach some of the most important life skills your students will ever learn.
• Improve your own driving skills.
• Make a difference in your community by teaching skills that can save lives and make our roadways safer.
Contact Susan Erickstad for further assistance.
E-mail: email@example.com
Professor Bradley J. Isberner teaches Traffic Safety Education at St. Cloud State University . He has extensive experience in driver education classroom instruction and combines current theories of instruction with practical application. Brad is a member of the Minnesota Drivers and Traffic Safety Education Association (MDTSEA) and the American Driver and Traffic Safety Education Association (ADTSEA). Professor Isberner's research has concentrated on issues relating to the prevention of impaired driving among youthful drivers. Brad has numerous publications in the Minnesota Driver Education Milepost Newsletter, a publication specifically focusing on Traffic Safety Education.
He can be reached via e-mail at firstname.lastname@example.com


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I'm looking to buy Gerber zwieback toast for my 7 month old. I live near DC and used to be able to buy it in Giant grocery stores, but they no longer sell them. I tried Walmart and they didn't have them either. Has Gerber stopped making them?
Why can't I find zwieback toast in stores anymore?
Mum Mum's are great! They aren't messy like Biter Biscuits. Zwieback were discontinued.
Mommy to Collum 03/06 and Cash 06/08, and a beagle named Roux
I have Gerber Zwieback - lots of it - I work for a wholesale distributor that sells this product to local stores. We have a web site and Amazon store- if anyone needs this product we have it at United Sales and Distributors you can email me at firstname.lastname@example.com
There is a lot of zweiback toast by us, but I can't find the gerber biter biscuits anywhere! I hope they come back soon - DD loves them and they help her teething so much!
Deb, mom to: a Princess, a Prince, a Princess, & a tail-wagger
You never know how STRONG you are until being STRONG is the only choice you have.
I know this post is a few months old.. but my daughter had her first baby in November 09 and asked something similar and I like zwibeck toast with my fruit in the AM.
Most stores don't carrry it any longer I found that out as well, but
go to www.amazon .com and type in zwibeck toast and you will find both the original and then a variety of them from Gerber and other companies for teething toddlers.
i can find bitter biscuits but come to think of it i haven't seen zwieback in quite some time...hmmm
I'd call you a tool, but even THEY serve a purpose
"For all intensive purposes, this is mind bottling"
Ditto. In my area, you CANNOT find zwieback toast, just the biter biscuits. We've had to make do, but I miss them!
Idiots are fun! No wonder every village wants one. - House
You may want to try Indian or South African sections in a large supermarket or in an ethnic specialty store. Rusk is a traditional zwieback type biscuit eaten in these countries and used for teething babies as well as adult snacks.
I bought the biter ones and the mum mums. My six month old now has six teeth. So he is a teething fool. The mum mums are so thin he bites off pieces easily and then chokes on them. The biter ones he can chew and desolve (he has bit off a chunk of that one too). They are messy but I just do it before I am going to change his clothes. He is either in the walker or a high chair and the clean up is super easy because that stuff desolves so fast.
Now maybe I will look for rusk biscuits, thanks!
The biter biscuits are all the place around here. Never seen or heard of that zwieback toast.
"Both are salty, one will give me carpal tunnel, I'll go with the fries." - Iliza Shlesinger
HAHA! I just came back to this post and realized it's way old! Lol.
"Both are salty, one will give me carpal tunnel, I'll go with the fries." - Iliza Shlesinger


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Kids' favorite characters from the Disney movie Planes are flying in. Disney Planes Bravo is based on the Navy jet fighter who, in the movie, keeps the air space safe during the big air race. This authentically styled die-cast plane features real rolling wheels and moving propellers. It also includes a universal connector in its belly to attach accessories and playset features (sold separately).
With this die-cast plane, Planes fans can recreate scenes from the movie or imagine all-new flying adventures. This is a fun way for kids to engage with a character they like watching on the big-screen.
Disney Planes Bravo is for ages 3 and up.
Additional Disney Planes die-cast planes are available and sold separately.
Disney Planes Muir Train Transporter
from Mattel
Planes Waterfall Rescue Track Set
from Mattel
Planes Maru's Gas Up and Go Stop
from Mattel
Disney Planes Fire & Rescue Air Attack Training Playset
from Mattel
Planes Dottie's Fix and Fly Hangar
from Mattel
Disney Planes Bop Bag
from Hedstrom
Disney Planes Hopper
from Hedstrom
Disney Planes In the Lead!
from Random House/Disney
Disney Planes Micro Drifters Air Dare Loop Track Set
from Mattel
Disney Planes Action Shifters Flight to the Finish Speedway
from Mattel


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Comments (6)
With our next one, we are going to wait until 6 weeks to take the baby in for it's birth certificate and go the urine test route. There is controversy over waiting that long. I personally eat a fairly low PKU diet, so I am not worried.
What do you mean by a low PKU diet? Mostly vegetatarian, or vegan?
Edit: Actually read your signature on another post. Sorry!! Yours is easier to read, but I sometimes skip them because the abbreviations are not things I can decipher and am familar with.
WDF!!! Doing things slowly - BS3 @ 4.5 months and BS3b-28% in 1 year. Super smart DS 3/02, Sweet baby girl 7/11 Due Feb/13
Am not sure about urine sample testing but my cousin was happy about at least the wide range of disorders including PKU and that her baby girl was not pricked for blood. I also find it a better way to test and shall be opting for in in June :)
Can you share the list of centers where the kit can be ordered or details taken ?
Ya I checked with my sis who got it done internationally when in Jakarta. Its the same company. But theres one more in Germany too, though expensive. Her logic was that the test covers so many disorders and its always prudent to take the benefit of this science whether the disorders are there in a list of state or not. Personally, come June I'd rather take all possible tests/steps to ensure "maximum" safety to my baby. Whats your decision ?
Oh. You must quickly look at all options for testing your toddler for all possible disorders. As far as I know, an early treatment avert the problems to a great extent, but surely your doctor will need to know the disorder first. At least, you will be at peace of mind by ruling our more and more possibilities. My best wishes.


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The rain hitting a metallic roof in a parking. iRiver HP-140 Ext. Mic. mp3 192 kbs, Adobe Audition > Normalize
Full volume pink noise in stereo
This is a stereo rendering of pink noise optimized for the highest quality in a portable format that most music ...
The air is alive with the buzz of weird technology and energy. Created by running an image through audiopaint.
field recording made near Piccadilly Circus, London, of a fountain. Mainly the sound of water with background chatter from tourists ...
This sound was recorded by an Olympus WS550-M. This sound is the traffic sound in the entrance roundabout of Figueres.
The sound of a train entering an outdoor above ground station.
A 10 second pink noise wave generated using Audacity. Brown noise/red noise/random walk noise, is the kind of signal noise ...
This sound was recorded with an Olympus WS550-M and it's the sound of the sweeper's vehicle cleaning the streets and ...
KONICHIWA! Free SE from Japan http://taira-komori.jpn.org/freesounden.html
generated by char-rnn (original karpathy), random samples during all training phases for datasets drinksonus, exwe, arglaaa
Evil sounding loop of the living dead... with a theta brain wave entrancement script of binaural beats.
2 minutes of Pink Noise
This sound was recorded with an Olympus WS-550M and it's the sound of the water of the light fountain
pinku noise


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Charges against trespassers droppedPublished 1:46pm Thursday, June 20, 2013
Criminal trespassing charges against four men who made a protest march on the construction site of Wind Creek Wetumpka Casino were dropped
The fourth man, so-called
"Muscogee Warrior" Wayland Gray, still faces an Aug. 29 trial on another misdemeanor charge.
Gray, Michael Deo, Mike Harjo and an Alabama man named George Mead, who referred to himself as "Maggot," will only have to pay court costs on the criminal trespass charges incurred when they entered the Poarch Creek Indian property in January with a stated intent to pray for their ancestors interred there.
They consider the land around the quickly-rising casino and hotel sacred ground, and refer to it as Hickory Ground, the name it was given by the Creek ancestors of both the Poarch Creek and Muscogee nations.
Property management denied them entry, stating that it would be unsafe for the men to enter the active construction zone.
The next day, the four men approached the casino and were stopped by security and subsequently arrested. In addition to the trespassing charges, Gray was arrested for making a terrorist threat, but an Elmore County grand jury did not return an indictment on that charge.
"These charges are a smokescreen to divert attention away from the desecration of Hickory Ground," Gray said. "The issue is respect for ancestors, and the precedent this case sets for all Native people trying to protect sacred land and burials,"
More than 40 men, women and children rode a chartered bus from Oklahoma to witness the brief hearing. There was no room for them in the courtroom, however, as Gray, Harjo, Deo and Mead's cases were heard by Judge Glenn Goggans among the regular docket of traffic court, drug arrests and other business.
"These men notified the authorities they were coming," Gray's attorney, former AG Bill Baxley, said. "They were trying to exercise their freedom of religion, their civil right of religion. And they wanted to pay their respects to their ancestors."


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- Differential Diagnosis
- Diseases
- Drugs
- More
- Try building your search one term at a time, and be as specific as you can! Search term example: "chronic cough".
- Do not enter multiple findings such as "anemia, chronic cough, weight loss, vomiting" all at the same time.
- After selecting your term from the search results a list of possible diagnoses will be generated. If the list is too long, you will be able to narrow it down by entering additional terms.
- Do not enter values such as "heart rhythm 110" or "sodium 125", instead use "tachycardia" or "hyponatremia".
Sign-in (or register) to check out the new features we've just launched!
Differential Diagnosis For Patient/Sleeping status
Available only to registered users.
- Suggest
- 8 possible diagnoses found
- Allergic, Collagen, Auto-Immune Disorders
- Asthma
- Hereditary, Familial, Genetic Disorders
- Brugada syndrome/Hereditary VT/VF
- Relational, Mental, Psychiatric Disorders
- Sleep terror disorder
- Anatomic, Foreign Body, Structural Disorders
- Gastric acid aspiration, chronic
- Vegetative, Autonomic, Endocrine Disorders
- Sleep apnea syndrome
- Nocturnal leg cramp syndrome
- Nocturnal myoclonus syndrome
- Reference to Organ System
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Are you Shun-le Chen?Claim your profile
Publications (32)47.81 Total impact
Article: Expression, Localization, and Clinical Application of the RNA Binding Domain of U1-70kD in HEp-2 Cells[Show abstract] [Hide abstract] ABSTRACT: To develop an improved substrate for indirect immunofluorescent test (IIF) to detect anti-U1-70kD autoantibodies. The RNA binding domain of U1-70kD (U1BD) complementary DNA was obtained from human larynx carcinoma cell line HEp-2 by reverse transcription-polymerase chain reaction (RT-PCR) and cloned into the mammalian expression vector pEGFP-C1. The recombinant plasmid pEGFP-U1BD was transfected into HEp-2 cells. Immunoblotting (IBT), confocal fluorescence microscopy, and IIF were used to confirm the expression, localization, and antigenicity of fusion proteins of green fluorescent protein (GFP) in transfected HEp-2 cells, which were then analyzed by IIF using human reference sera and compared with untransfected HEp-2 cells simultaneously. (1) The HEp-U1BD cells thus obtained retained their ability to express U1BD-GFP, which showed the antigenicity of U1BD with a characteristic phenotype in IIF. (2) Fifteen IBT-positive anti-U1-70kD sera presented with characteristic cytoplasmic staining on HEp-U1BD by IIF, but five sera without the 70kD reactive band in IBT were not found in the presence of HEp-U1BD pattern. Ten sera of healthy donors couldn't react with HEp-2 and HEp-U1BD at 1:80 attenuant degrees. (3) No differences in expression, localization, or morphology were observed when HEp-U1BD or HEp-2 interacted with the reference sera that could react with Ro/SSA, La/SSB, centromere, histone, and Scl-70 antigens in routine IIF test. HEp-U1BD cells kept the immunofluorescent properties of HEp-2 cells in an immunofluorescence anti-nuclear antibody (IFANA) test and could be potentially used as a substrate for routine IFANA detection. © 2015 by the Association of Clinical Scientists, Inc.
- [Show abstract] [Hide abstract] ABSTRACT: Lupus nephritis (LN) is a common and important manifestation of systemic lupus erythematosus (SLE). Evidence suggests higher rates of lupus renal involvement in Asian populations, and maybe more severe nephritis, compared with other racial or ethnic groups. The management of LN has evolved considerably over the past three decades, based on observations from clinical studies that investigated different immunosuppressive agents including corticosteroids, cyclophosphamide, azathioprine, mycophenolic acid, calcineurin inhibitors and novel biologic therapies. This is accompanied by improvements in both the short-term treatment response rate and long-term renal function preservation. Treatment guidelines for LN have recently been issued by rheumatology and nephrology communities in U.S.A. and Europe. In view of the racial difference in disease manifestation and response to therapy, and the substantial disease burden in Asia, a panel of 15 nephrologists and rheumatologists from different Asian regions with extensive experience in lupus nephritis - the Steering Group for the Asian Lupus Nephritis Network (ALNN) - met and discussed the management of lupus nephritis in Asian patients. The group has also reviewed and deliberated on the recently published recommendations from other parts of the world. This manuscript summarizes the discussions by the group and presents consensus views on the clinical management and treatment of adult Asian patients with LN, taking into account both the available evidence and expert opinion in areas where evidence remains to be sought.
Article: Expression, localization and clinical application of exogenous Smith proteins D1 in gene transfected HEp-2 cells[Show abstract] [Hide abstract] ABSTRACT: To establish an improved substrate for an indirect immunofluorescence test (IIF) to detect anti-Sm antibody. Full-length Smith protein D1(Sm-D1) complementary DNA was obtained from human larynx carcinoma cell line HEp-2 by reverse transcription - polymerase chain reaction (RT-PCR) and cloned into the mammalian expression vector pEGFP-C1. The recombinant plasmid pEGFP-Sm-D1 was transfected into HEp-2 cells. The expression, localization and antigenicity of fusion proteins of green fluorescent protein (GFP) in transfected cells were confirmed by means of immunoblotting (IBT), confocal fluorescence microscopy and IIF analysis. Transfected HEp-2 cells were analyzed with reference serum and compared with untransfected HEp-2 cells by IIF. Stable expression of the Sm-D1-GFP was maintained for more than ten generations. This Sm-D1-GFP showed the antigenicity of Sm-D1 with a characteristic phenotype in IIF.Six of 12 serum specimens from systemic lupus erythematosus contained both 29/28 and 13.5 kDa proteins and showed characteristic immunofluorescent patterns. The same phenomenon appeared in 3/6 serum samples which contained 29/28 kDa proteins only. Sera from 10 healthy donors did not react with HEp-Sm-D1 or HEp-2 at 1:80 attenuant degrees. No alteration in expression, localization and morphology was observed when HEp-Sm-D1 or HEp-2 interacted with the reference sera which could react with Ro/SSA, La/SSB, β2GP1, centromere, histone, and Scl-70 antibodies in routine IIF tests. As a new kind of substrate of IIF, HEp-Sm-D1 can be used to detect anti-Sm antibodies. Transfected HEp-2 cells keep the immunofluorescent property of HEp-2 cells in immunofluorescence anti-nuclear antibody (IFANA) test and could potentially be used as substrate for routine IFANA detection.
Article: A genetic role for macrophage migration inhibitory factor (MIF) in Adult-onset Still's disease.[Show abstract] [Hide abstract] ABSTRACT: Introduction Adult-onset still's disease (AOSD) is a rare systemic inflammatory disorder in which abnormalities in inflammatory cytokines production appear to play a pathophysiological role. Our previous work has reported increased expression of macrophage migration inhibitory factor (MIF) and revealed its correlation with disease severity and activity in AOSD. A -173 G/C single nucleotide polymorphism (SNP) (rs755622) and a -794 CATT5-8 repeat (rs5844572) in the MIF promoter have been reported. In this study, we sought to explore the relationship between functional MIF promoter polymorphisms and MIF expression in AOSD. Methods 100 patients and 200 controls were recruited in the study. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was utilized to analyze the -173 G/C SNP (rs755622) and PCR-based size discrimination assay was applied to detect the -794 CATT5-8 repeat (rs5844572) in the MIF promoter. Plasma MIF levels were measured by ELISA. MIF mRNA levels were quantified by real-time reverse transcription (RT)-PCR. Bisulfate genomic sequencing was employed to evaluate DNA methylation status within the MIF promoter. Results We identified that the frequencies of MIF -794 CATT5 (P = 0.001) allele and the expression of MIF (P <0.001) were increased in patients compared to healthy controls. Plasma levels of MIF in patients with CC genotype were higher than those of patients with GC or GG genotypes (P = 0.05). In patients with established AOSD, a higher frequency of -794 CATT7 containing MIF genotypes was observed in those with liver dysfunction (P = 0.009). Haplotype analysis revealed a higher representation of the MIF haplotype defined by -173*C/-794 CATT5 (C5) in AOSD patients (P = 0.001). Conclusion Functional promoter polymorphisms in the MIF gene influence plasma MIF levels in AOSD and may contribute to disease susceptibility or clinical presentation of AOSD.
Article: Etoricoxib versus indometacin in the treatment of Chinese patients with acute gouty arthritis: A randomized double-blind trial[Show abstract] [Hide abstract] ABSTRACT: Background: Acute gout is an intensely painful, inflammatory arthritis. Although the non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for this condition, the efficacy is based on only a few studies, particularly in China. We tried to assess the safety and efficacy of etoricoxib in the treatment of acute gouty arthritis in China. Methods: A randomized, double-blind, active comparator study was conducted at 10 sites in China. Patients (n = 178; ≥ 18 years of age) with acute gouty attack (< 48 hours) were treated for 5 days with etoricoxib (120 mg/d; n = 89) or indometacin (75 mg twice daily; n = 89). The primary efficacy end point was self-assessed pain in the affected joint (0-4 point Likert scale) from days 2 - 5. Secondary end points included investigator assessments of tenderness and swelling, patient/ investigator global assessments of response to therapy, and patients discontinuing treatment. Safety was assessed by adverse events (AEs). Results: Etoricoxib and indometacin had comparable primary and secondary end points. Mean change difference from baseline from days 2 - 5 was 0.03 (95% confidence interval (CI) -0.19 to 0.25; P = 0.6364), which fell within the prespecified comparative bounds of -0.5 to 0.5. No severe AEs were associated with etoricoxib use. Non-severe AEs were mainly digestive and general, and most (73.7%) were mild, although they caused withdrawal of two subjects in the etoricoxib group, due to bilateral renal calculi and uronephrosis of the left kidney (unrelated to etoricoxib) and fever and chills (potentially etoricoxib-related). Overall, AEs were similar, although the absolute number of AEs in the etoricoxib group (n = 31) was less than the indometacin group (n = 34). Conclusions: Etoricoxib (120 mg once daily) is effective in treating acute gout, is generally safe and well-tolerated, and is comparable in efficacy to indometacin (75 mg twice daily).
Article: New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus[Show abstract] [Hide abstract] ABSTRACT: Glucocorticoid (GC) therapy remains important in improving the prognosis of patients with systemic lupus erythematosus (SLE). However, some patients do not achieve an effective response with GC treatment, creating an obstacle to the remission of SLE. Identification of the underlying mechanisms responsible for steroid resistance can be significant. Macrophage migration inhibitory factor (MIF) arouses our interest because of its reciprocal relationship with GCs. In the present study, we investigated for the first time whether MIF correlated with steroid resistance in SLE and explored potential mechanisms of action. Sixty-two patients with SLE (40 steroid sensitive and 22 steroid resistant) and 21 normal controls were recruited. Serum levels of MIF were measured by ELISA. Cytosolic MIF and IκB expression in peripheral blood mononuclear cells (PBMCs) were determined by western blotting. The electrophoretic mobility shift assay was assessed by NF-κB in nuclear aliquots. Gene silencing was applied to reduce expression of MIF in PBMCs in steroid-resistant patients. PBMCs obtained from steroid-sensitive patients were treated with recombinant human MIF of different concentrations. MIF levels in serum and PBMCs were higher in steroid-resistant patients compared with steroid-sensitive patients and controls. In contrast to the steroid-sensitive group, NF-κB levels were significantly higher and IκB levels lower in steroid-resistant patients. After MIF gene silencing, IκB levels in cells from steroid-resistant patients were increased. In steroid-sensitive patients, a decrease in IκB levels and an increase in NF-κB expression from baseline were detected in PBMCs treated with a higher concentration of recombinant human MIF. Treatment with recombinant human MIF did not regulate expression of IκB and NF-κB in PBMCs from patients treated with an anti-MIF monoclonal antibody. Our results indicated that MIF may play a role in the formation of steroid resistance in SLE by affecting the NF-κB/IκB signaling cascade. As a regulator of glucocorticoid sensitivity, MIF may be a potential target for steroid sparing.
Article: Community-based epidemiological study on hyperuricemia and gout over 5 years in Huang-pu district, Shanghai
Article: Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population[Show abstract] [Hide abstract] ABSTRACT: Cytochrome P-450 2E1 (CYP2E1) is an important member of the CYP superfamily, which is involved in the metabolism and activation of many low molecular weight toxic compounds. We tried to investigate the possible association of CYP2E1 tag single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese Han population. The coding and flanking regions of the CYP2E1 gene were scanned for polymorphisms and tag SNPs were selected. A two-stage case-control study was performed to genotype a total of 876 SLE patients and 680 geographically matched healthy controls (265 cases and 288 controls in stage I and 611 cases and 392 controls in stage II). SLE associations of alleles, genotypes and haplotypes were tested by age and sex adjusted logistic regression. The gene transcription quantitation was carried out for peripheral blood mononuclear cell (PBMC) samples from 120 healthy controls. Tag SNP rs2480256 was found significantly associated with SLE in both stages of the study. The "A" allele was associated with slightly higher risk (odds ratio (OR) = 1.165, 95% confidence interval (CI) 1.073 to 1.265, P = 2.75E-4) and "A/A" genotype carriers were with even higher SLE risk (OR = 1.464 95% CI 1.259 to 1.702, P = 7.48E-7). When combined with another tag SNP rs8192772, we identified haplotype "rs8192772-rs2480256/TA" over presented in SLE patients (OR 1.407, 95% CI 1.182 to 1.675, P = 0.0001) and haplotype "TG" over presented in the controls (OR 0.771, 95% CI 0.667 to 0.890, P = 0.0004). The gene transcription quantitation analysis further proved the dominant effect of rs2480256 as the "A/A" genotype showed highest transcription. Our results suggest the involvement of CYP2E1 as a susceptibility gene for SLE in the Chinese population.
Dataset: Additional File 1[Show abstract] [Hide abstract] ABSTRACT: Supplementary Tables S1-S3. Supplementary Table S1: Clinical and immunological features of cases. Supplementary Table S2: Primers for CYP2E1 genotyping. Supplementary Table S3: Sequence variations identified in 96 healthy people in CYP2E1.
Article: [A multicenter, double-blind, placebo-controlled, randomized, phase III clinical study of etanercept in treatment of ankylosing spondylitis].[Show abstract] [Hide abstract] ABSTRACT: To evaluate the short-term efficacy and safety of etanercept treatment in Chinese patients with active ankylosing spondylitis (AS). This was a 12-week multicenter, double-blind, placebo-controlled, randomized phase III clinical study. The first part was a 6-week placebo-controlled period followed by a 6-week open-label period. The primary efficacy endpoint was the percentage of subjects achieving a 20% improvement in assessment in ankylosing spondylitis (ASAS) (ASAS 20). The secondary efficacy endpoints were the percentage of patients achieving a 40% improvement in ASAS (ASAS 40), achieving a 50% improvement in ASAS (ASAS 50), achieving a 70% improvement in ASAS (ASAS 70), and ASAS 5/6 responses at all visits, and the improvement in subject global assessment, physician global assessment, nocturnal and total back pain, bath AS functional index (BASFI), bath AS disease activity index (BASDAI), spinal mobility, joint assessment and quality of life assessment. All subjects in the study were evaluated for safety. The primary endpoint, ASAS 20 at week 6, was achieved by 86.5% (64/74) patients in the etanercept group compared to 29.5% (23/78) patients in the placebo group (P < 0.001). As early as week 2, the percentages of patients achieving the ASAS 20 between the two groups were significantly different. Furthermore, the majority of secondary efficacy end points were also significantly improved. Most of adverse events (AE) were mild in nature, the commonest adverse events were elevated liver function levels, injection site reactions and nasopharyngitis. No death or serious AE were observed. Etanercept can improve symptoms fastly, significantly and safely in Chinese patients with active AS.
Article: Evaluation of Risk Factors That Contribute to High Prevalence of Premature Atherosclerosis in Chinese Premenopausal Systemic Lupus Erythematosus Patients[Show abstract] [Hide abstract] ABSTRACT: To evaluate the prevalence of atherosclerosis in Chinese premenopausal women with systemic lupus erythematosus (SLE) and study possible associations between traditional and nontraditional risk factors with premature atherosclerosis. We evaluated 111 premenopausal women with SLE and 40 healthy controls without clinical cardiovascular disease. B-mode ultrasound was used to measure carotid plaque and intima-media wall thickness (IMT). The frequency of risk factors for atherosclerosis in patients and controls was compared, and the relationship between the patients' clinical characteristics and carotid plaque was examined. At the same time, we used B-mode ultrasound to measure flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) in the brachial artery to assess for difference in endothelial function between SLE patients and controls. Carotid plaque was more frequent in patients with lupus (16 of 111 patients) than in control subjects (0 of 40 subjects) (P = 0.007). The mean IMT was significantly higher in patients than in controls. Compared with controls, SLE patients were found to have a significantly higher prevalence of hypertension (P = 0.001), hypercholesterolemia (P = 0.022), and hypertriglyceridemia (P < 0.001). As compared with patients without plaque, patients with plaque were significantly older, had longer disease duration, higher body mass index, raised blood pressure, shorter prothrombin time, raised C-reactive protein, higher Systemic Lupus International Collaborating Clinics damage index score, higher cumulative prednisone dose, used less hydroxychloroquine, had higher mean IMT, lower FMD, and NMD. In logistic regression analysis, older age, higher body mass index, and higher Systemic Lupus International Collaborating Clinics damage index score were independently related to the presence of plaque. Using multiple regression analysis, we found SLE (P = 0.003) to be significantly associated with impaired FMD. In our Chinese SLE group, patients presented a higher prevalence of carotid atherosclerosis plaque than healthy controls. SLE patients have significant endothelial dysfunction. We found that risk factors identified in other SLE populations were associated with atherosclerosis in our Chinese group.
Article: T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis[Show abstract] [Hide abstract] ABSTRACT: T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism of action are largely undetermined. Rats with collagen-induced arthritis (CIA) were treated with T-614 (5 and 20 mg/kg) daily. Animals receiving methotrexate (1 mg/kg every 3 days) and the nonsteroidal anti-inflammatory agent nimesulide (10 mg/kg per day) were used as controls. A combination therapy group was treated with both T-614(10 mg/kg per day) and methotrexate (1 mg/kg every 3 days). Hind paw swelling was evaluated and radiographic scores calculated. Serum cytokine levels were assessed by Bio-plex analysis. Quantitative PCR was used to evaluate expression of mRNA for interferon-gamma, IL-4 and IL-17. Serum IL-17 and anti-type II collagen antibodies (total IgG, IgG1, IgG2a, IgG2b and IgM) were measured using ELISA. Oral T-614 inhibited paw swelling and offered significant protection against arthritis-induced cartilage and bone erosion, comparable to the effects of methotrexate. CIA rats treated with T-614 exhibited decreases in both mRNA expression of IL-17 in peripheral blood mononuclear cells and lymph node cells, and circulating IL-17 in a dose-dependent manner. T-614 also reduced serum levels of tumor necrosis factor-alpha, IL-1beta and IL-6. A synergistic effect was observed for the combination of methotrexate and T-614. In addition, T-614 (20 mg/kg per day) depressed production of anti-type II collagen antibodies and differentially affected levels of IgG2a subclasses in vivo, whereas IgM level was decreased without any change in the IgG1 level. Together, the findings presented here indicate that the novel agent T-614 has disease-modifying effects against experimental arthritis, as opposed to nimesulide. Our data suggested that T-614 is an effective disease-modifying agent that can prevent bone/cartilage destruction and inflammation in in CIA rats. Combination with methotrexate markedly enhances the therapeutic effect of T-614.
Article: The levels of macrophage migration inhibitory factor as an indicator of disease activity and severity in adult-onset Still's disease[Show abstract] [Hide abstract] ABSTRACT: This study investigated the levels of macrophage migration inhibitory factor (MIF) in adult-onset Still's disease (AOSD) and explored the role of this pro-inflammatory cytokine in the systemic inflammation of AOSD. Serum MIF levels were measured by ELISA in patients with AOSD and controls. Intracellular MIF production by peripheral blood leukocytes was detected by three-color flow cytometry. Serum MIF levels were significantly increased in patients with AOSD. Serum MIF levels were significantly higher in AOSD patients with sore throat, myalgias, splenomegaly, or pleuritis, and were closely correlated with clinical disease severity and activity. Examined by flow cytometry, the intracellular MIF levels in monocytes and T-lymphocytes from AOSD patients were significantly higher than those from healthy subjects. These data represent the first demonstration of increased MIF expression in AOSD, and suggest that MIF may be an important marker for disease evaluation and monitoring.
Article: Adult clinically amyopathic dermatomyositis with rapid progressive interstitial lung disease: A retrospective cohort study[Show abstract] [Hide abstract] ABSTRACT: The aim of the study was to investigate the characteristics of adult clinically amyopathic dermatomyositis (CADM) with rapid progressive interstitial lung disease (ILD). Hospitalized patients with dermatomyositis (DM) and polymyositis (PM) between 1998 and 2005 in the Shanghai Renji Hospital were retrospectively studied. One hundred and forty-five patients were classified into CADM, classic DM or PM according to the modified Sontheimer's definition or Bohan-Peter's classification criteria. They were further stratified based on the presence or absence of clinical ILD. The Kaplan-Meier survival analysis and COX regression were performed. The predictive factors for ILD and other clinical properties of CADM-ILD were explored. The presence of clinical ILD was a significant risk factor for the poor outcome of DM/PM (OR = 4.237, CI 95%: 1.239-14.49, p = 0.021). Other risk factors are the presence of rashes and elevated urea nitrogen. Patients with DM/PM complicated by ILD had different clinical courses. Patients with CADM-ILD showed a rapidly progressive pattern with 6-month survival rate of 40.8%. The DM-ILD manifested a progressive pattern with a 5-year survival rate of 54%, while PM-ILD was chronic with 5- and 10-year survival rate of 72.4% and 60.3%, respectively. Better preserved muscle strength, elevated erythrocyte sedimentation rate, and hypoalbuminemia may herald ILD in DM/PM. Patients with CADM-ILD who later died had lower PO(2), higher lactate dehydrogenase, and prominent arthritis/arthralgia compared with those who survived. The presence of antinuclear antibody seems to be protective. Rapid progressive CADM-ILD is refractory to conventional treatment. ILD is a common complication in over 40% of our hospitalized DM/PM cohort and is also a prominent prognostic indicator. CADM is a special phenotype of DM/PM. CADM-ILD, which is usually rapidly progressive and fatal, requires further investigation.
- [Show abstract] [Hide abstract] ABSTRACT: Aim: To examine the effects of a novel immunosuppressant, FTY720, on BXSB lupus-prone mice, and to investigate its immune regulatory pathway by using a cDNA microarray. Methods: Male BXSB mice received oral administration of 10 mg/kg FTY720 twice a week from age 9 weeks. Levels of antinuclear antibodies in serum and histopathology of the kidney were evaluated. The gene expression profile of splenic lymphocyte was analysed by cDNA microarray. Results: FTY720 suppressed the production of antinuclear antibodies (P < 0.05) and reduced the deposition of IgG in glomeruli, compared to control animals. The microarray determined 247 differential expressed genes, which contained a cluster of genes related to lymphocyte trafficking and cytoskeletal remodeling. Conclusion: Our preliminary data suggests FTY720 has some immune suppressive effect on BXSB mice. The mechanism may be due to accelerate lymphocyte homing and redistribution which differs from traditional cytotoxic agents. Its clinical implication deserves further study.
Article: Clinical features, prognostic and risk factors of central nervous system infections in patients with systemic lupus erythematosus[Show abstract] [Hide abstract] ABSTRACT: The purpose of this study is to describe the etiology, characteristics and outcomes of central nervous system (CNS) infections in patients with systemic lupus erythematosus (SLE), while also identifying prognostic and risk factors. Thirty-eight SLE patients with CNS infections were identified from review of all charts of patients with SLE hospitalized from January 1995 to June 2005. These patients were divided into 3 groups, i.e., Mycobacterium tuberculosis (TB), non-TB bacterial and fungal infection groups. Of the 38 SLE cases with CNS infections, TB was identified in 19 patients, Listeria monocytogenes in 3 patients, Klebsiella pneumoniae in 1 patient, Staphylococcus aureus in 1 patient, Gram's stain positive bacteria in 1 patient, Cryptococcus neoformans in 12 patients, and Aspergillus fumigatus in 1 patient. The rate of unfavorable outcome in patients with fungal infection was lower than in patients with TB (P=0.028) and non-TB bacterial CNS infections (P=0.046). SLE patients with TB or fungal CNS infections had a more insidious or atypical clinical presentation. Compared to SLE patients without CNS infections, those with CNS infections were more likely to have low serum albumin levels (P=0.048) and have been receiving higher doses of prednisolone at the onset of CNS infection (P=0.015) or higher mean doses of prednisolone within the previous year (P=0.039). In conclusion, low levels of serum albumin and higher doses of received prednisolone are important risk factors for the development of CNS infections in SLE patients.
- [Show abstract] [Hide abstract] ABSTRACT: Takayasu's arteritis (TA) is a vasculitis characterized by inflammation and obliteration of intermediate to large-size arteries. We report a case of Takayasu's arteritis with a presentation of bilateral pulmonary nodular infiltrates in a 21-year-old man. An open-lung biopsy showed characteristic changes of extra-vascular granulomatosis. To our knowledge, this has not been described previously in the literature.
Article: Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice[Show abstract] [Hide abstract] ABSTRACT: The combined presence of anti-phospholipid Ab (aPL), thrombosis, and/or fetal loss is recognized as the antiphospholipid syndrome (APS). aPL include anti-cardiolipin Ab (aCL) and/or lupus anticoagulants (LAC, detected as Ig that prolong certain in vitro phospholipid (PL)-restricted blood clotting tests); both aCL and LAC are the diagnostic Ab for APS. Studies show that aPL represent a heterogeneous group of Ab, which recognize various PL, PL-binding plasma proteins, and/or PL-protein complexes. Recently, we found that five of seven patient-derived IgG monoclonal aCL react with thrombin, activated protein C, and plasmin. All three proteins are trypsin-like serine proteases (SP), and are highly homologous in their catalytic domains. Importantly, among these SP autoantigens, the reactive aCL bind to plasmin with the highest affinity, suggesting that plasmin may serve as a major driving autoantigen for some aCL in approximately 30% of APS patients who are positive for IgG anti-plasmin Ab. To test this hypothesis, we immunized BALB/c mice with human plasmin and analyzed immune sera for aCL activity and reactivity with relevant SP. We found that some immune sera displayed aCL activity and/or bound to test SP. Subsequently, eight mAb were obtained and studied. The results revealed that one mAb displayed the aCL and the LAC activities and induced fetal loss when injected into pregnant mice. Immunohistological analyses of placentas revealed extensive deposits of activated C3 components. Combined, these data demonstrate that plasmin may serve as a driving Ag for some pathogenic aPL.
Article: Could 2′5′-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study[Show abstract] [Hide abstract] ABSTRACT: 2'5'-Oligoadenylate synthetase (OAS) was shown to be related to systemic lupus erythematosus (SLE) 20 years ago, and was rediscovered to be involved in type I interferon pathway in SLE by several microarray gene expression studies recently. The goal of this study was to investigate OAS isoform expressions in lupus patients, to evaluate whether they could become biomarkers to differentiate between disease flare and infection. Fifty-four SLE patients presented with fever or systemic inflammatory syndrome, or both, were enrolled. Gene expressions of OAS1, OAS2, and OASL were studied by using real time PCR in active SLE (SLEDAI >or=9, n=29) and in those complicated with infections (n=25). The latter group was composed of 19 patients with invasive bacterial infections, and six patients with viral infections. C reactive protein (CRP) and other clinical parameters were also measured. Twenty-nine healthy individuals made up a normal control group. The mRNA expressions of OAS1, OAS2, and OASL were higher in patients with lupus flares than those with infections (p<0.03), or normal controls (p<0.001). SLE complicated with infections have higher OAS1 expression level (P=0.002), lower OASL (P=0.004), and equivalent OAS2 (P=0.135), when compared with those of normal controls. OASL expression level was negatively correlated with infection in lupus by logistic regression analysis (p=0.008). Area under the receiver operating characteristic curve for the prediction of infection was 0.92 (p<0.0001) for OASL, and 0.77 (p=0.007) for CRP. Therefore, our preliminary data suggest that the pattern of OAS isoform expressions, OASL in particular, may provide useful information in differentiating disease flares from certain infections in SLE.
Article: A 1-year study of two doses of steroid in combination with methotrexate and chloroquine in the treatment of patients with mild and moderate systemic lupus erythematosus[Show abstract] [Hide abstract] ABSTRACT: Aim: This is a retrospective study on the efficacy and adverse effects of treating mild or moderate systemic lupus erythematosus without major organ involvement using small dosage prednisone combined with MTX and chloroquine (PMC). Methods: As a retrospective 1-year follow-up study, clinic outpatients (Rheumatology Department, Renji Hospital, Shanghai, China) were divided by predinisone dose (Group A, prednisone ≤ 0.2 mg/kg/d; Group B prednisone 0.5–0.6 mg/kg/d). All patients (N = 30 per group) were also administered methotrexate (7.5–10 mg/week) and chloroquine (250 mg/d). Efficacy and adverse effects of the two protocol drug regimens were compared. Results: The OUT Score of Group A was reduced from 2.10 ± 1.45 to 0.94 ± 0.73, and Group B from 2.93 ± 2.26 to 1.3 ± 1.29. The treatment was successful and there was no significant difference of efficacy between these two groups. However, the infection rate was much higher in Group B than in Group A (P < 0.001). Most infections occurred in the lung, while infections of the skin were recorded. There were also three patients who presented with Cushing syndrome in Group B. Aseptic necrosis of the femoral head was noted in Group B, but none in Group A. Conclusions: Systemic lupus erythematosus patients with mild or moderate activity, and without major organ involvement, can be controlled well with PMC. Otherwise, it was noted that higher doses of prednisone leads to more infections.
Top Journals
Shanghai Jiao Tong University
Shanghai, Shanghai Shi, China
- Department of Rheumatology
Renji HospitalShanghai, Shanghai Shi, China
Second Military Medical University, ShanghaiShanghai, Shanghai Shi, China


text:
Hitomi 3DS Render 10 by x2gonWatch
©2013-2016 x2gon
Hitomi by BoobsonX
Volleyball by protocolx27
Background by lonewolf117
Volleyball by protocolx27
Background by lonewolf117
Is there a Mesh download we can get for this Bikini that would work in Resident Evil 6 ?
my favorite DoA Char.
she looks great.
Can you render another of this?
So much life in this one! Excellent!
Very sexy! Well done.Hope you do some Sarah's image,thanks.
This might be the best render you have ever done. A great pose for Hitomi in her hottest bikini, well done sir!
Hellll yessssss thank you so much!!!!!
Sexy hitomi ^^
Oh my gosh!!! Nicely done, X2! Hitomi looks so sexy in this render. I love it very much, Well done!
oh god i wish i could make such awesome and beautiful pics too.you are a really great artist!
Oh God this is awesome, Gon!!! Beautiful pose!!!


text:
Gentrieve 2 is a "Metroid"-style 3D action game featuring completely random & customizable worlds.
The year is 3080. Mass Generators are creating everything, everywhere. However, thieves often steal Mass Generators in hopes of creating robot armies & fortresses. Thieves are terrible programmers, though, and their creations become uncontrollably hostile & fortresses wildly convoluted.It is your job to clear out these fortresses & return the faulty Mass Generators. Be warned, when the Mass Generator is taken offline, the fortress will soon implode!
Please visit the homepage @ Gentrieve.wordpress.com for more information, demos & the full version!
Hello fellow swimmers & good news, Spermination has been updated! Of course, you always want to be shooting with the freshest, so grab the latest either from IndieGameStand or BMT Micro!
v1.4 brings fixes to joystick controls (should hopefully fix looking around on all types of controllers). Oculus Rift updates have also been made -- GUI elements shouldn't overlap incorrectly, among other fixes.
There was a rather large balancing tweak made for v1.0, so if you are running an older version, you really want to update as prices were changed & damage tweaks were made.
Are you a Let's Player who wants to play Spermination? Let me know! Send me an e-mail to phr00t at the usual gmail dot com, and I can hook you up. Here is a video of another fellow gamer enjoying himself:
As always, please vote on Greenlight for this title! Want to play? You can buy it on IndieGameStand!
Fight the battle you already won, but never remember. It is you up against 1000 other sperm fighters. Can you beat off your competition and come first?
Pay what you want for 3089 @ IndieGameStand! Beat the average and get Gentrieve 2! This is the cheapest the full version of 3089 will be on sale for!
Ignore the springtime sun and grab great IndieRoyale games including: Knytt Underground, The Real Texas, Monday Night Combat, Satazius and Gentrieve 2.
Gentrieve 2 is now on sale! 50% off the normal price. Also, Gentrieve 2 has seen some updates thanks to your feedback -- now more of you can enjoy the...
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I've just bought the game from Gamers Gate but cannot get the game to work. I get the message "Failed to create display. LWJGL Exception: Failed to set display mode (-2)." My video card is an Nvidia GTX 560 TI and I'm running Windows 7
What did you have set for your graphics settings when starting the game? Have you tried running in a windowed mode or full screen? For some reason, the engine I am using cannot initiate a 3D window to display the game...
The settings I've enabled are:
1920x1080, 32bpp, 59hz, 16x, Fullscreen and VSync
Thankyou for your help
I tried all of that but still no luck I'm afraid. I still get exactly the same error message
Hmm, have you tried a different resolution? Perhaps try windowing it at 1024x768 first, "display mode (-2)" may refer to the resolution.
I'm afraid that also didn't work. Could it be that my version of Windows 7 is 64 bit? Whatever, it's looking like I've wasted my money. I know it was cheap but that's not the point. If I'm going to give money away, I'd rather it was to charity!
Try setting it to 60hz or disabling Vsync. If that doesn't work try 24bpp or 16bpp.
I've tried that but I'm afraid that didn't work either. But thankyou for trying to help. I've bought a lot of indie games, especially since Gamersgate have been doing all their cheap bundle deals and I've built up quite a collection now (not just indie games but ALL games and I have most of the top rated games, new and old - I'm housebound thru disabilty, so the computer is my lifeline and has stopped me going completely mad!). This is the only one I havent been able to get working!
Well, I've been gone for a very long time due to excessive amounts of work, but I've recently downloaded v1.11, and I have to say I love it. Every change has only made the game better and more playable (I am sad about my box-fu being nerfed), though I have noticed a few little issues. Firstly, the glow effects seem to be slightly broken. When active, they can often be seen through objects, and also glitch the map so that walls often have black squares in the center of them (I'll post a screenshot in the thread). Also, when you land after a jump, you seem to bounce forward slightly in the direction you were moving before the jump began, which is slightly annoying when yo make a jump moving north, turn during it and go south, then land and end up bouncing slightly north again.
Aside from that, it's great! Though regrettably I'll probably be unable to do the "raceone" challenge due to term projects and exams being due soon.
Additionally, when loading a game, the "Door not opened" flash goes above the door icon. Pic here Imgur.com
That is actually how I originally designed it to look, but then the flash went around the door icon (which I think looks better), but I'm not sure why that happens (or why it reverts sometimes back to drawing over the icon)... another 3D rendering oddity with the engine, I suppose :-P
The glow effect being seen through walls happens when the walls have some transparency to them (even if it is unnoticeable)... I believe this is a limitation of the jMonkeyEngine glow effect I am using. I'm not entirely sure why the black squares show up on the map, but it is such a small oddity I haven't spent too much time on it (lots of bigger stuff to do!). The bounce-forward effect is from yourself rolling in the air after takeoff... if you jumped left, you'd probably bounce a bit left after landing.
I'll make a shorter contest when I return from my mini-vacation... the "raceone" is a bit long :P
Highest Rated (5 agree) 10/10
Gentrieve 2 is a fascinating experiment in procedural generation. Gameplay is 3D Metroid-style -- a room-based FPS platformer -- but genre is less important here than the ideas the game presents and the mood it effectively sets. In the style of roguelikes and dungeon crawlers, each play-through provides a unique experience through random generation, right down to the texture of the walls. The aesthetic is refined (dark, retro-futuristic) and I'm constantly propelled by my curiosity and eagerness…
Aug 30 2012 by burtz87


text:
11,127pages on
this wiki
this wiki
water.dat file contains information about the water planes inside a boundary, which normally has the same size as the map boundary. It corresponds to the
water1.dat file, and it is located in the
GTA San Andreas\data\ directory. The maximum amount of water planes is 1021, but you can increase it using the Limit Adjuster by User:Sacky.
Image of both:
File:Water dat.png
- – by User:Gforce
- Water IO Script for 3ds Max – by User:ocram88
This page is licensed under the GNU Free Documentation Licence. This page has a separate license to the CC-BY-SA that applies to most of GTA Wiki.
The full text of the GNU FDL v1.2 is here. Click the "History" button to see the full list of authors. See GTA Wiki:Copyright for more detail on our copyright policy.
Technical IMG | DFF | TXD | IDE | GXT | Handling | Carcols | Dynamic Object Mods Hot Coffee Modification | Create a Mission Tools GGMM Game Files Animviewer.dat/GTAVC | Bink | Default.dat/GTAVC | Chassis Vlo | Fistfite.dat/GTAVC | Flight.dat | Gta vc.dat | Object.dat/GTAVC | OpenGTA2 |Particle.cfg/GTAVC | Particle (SA) | Paths | Ped.dat/GTAVC | Pedgrp.dat/GTAVC | Pedstats.dat/GTAVC | Scenarios.dat | Scripted Path | Surface.dat/GTAVC | Surfaud.dat | TimeCyc Definition | Timecyc.dat/GTAVC | Train.dat/GTAVC | Train.dat/GTAVC | Train.dat/GTAVC | Train2.dat/GTAVC | WAD | WBD-WBN | WPFL | Water.dat | Water.dat/GTAVC | Weapon.dat/GTAVC Weaponinfo.xml Multiplayer Multi Theft Auto, Vice City Multiplayer, San Andreas Multiplayer


text:
Hernandez and Tatanka
A post on Twitter where Shawn Hernandez reveals that he recently met Tatanka, whom he calls a WWE legend, backstage at some sort of event.
October 24, 2015
Low Ki leaves TNA
A post on Twitter where Low Ki reveals that he has decided to leave TNA. He shares his feelings towards the company and thanks the fans. For those that missed Impact Wrestling this week, Hernandez made his return to the company and joined the Beat Down Clan.
June 25, 2015


text:
While Seattle Restaurant Week gave me the opportunity to try an "upscale" eatery at a discounted price (see last week's Sexy Feast write-up of The Coterie Room, which showed how a quenelle of anise hyssop ice cream taught a lesson about spooning), it also let me visit a restaurant that's long been on my to-do list: Nell's in Greenlake. I'd continually heard good things about Nell's, but typically forgot about it as a destination, and despite many walks around Green Lake, didn't even know its exact location.
As at The Coterie Room, rhubarb, in season, would show up in the dessert: strawberry rhubarb crisp with ginger ice cream. Preceding that: grilled top sirloin steak with celery root puree, Brussels sprouts, and shallot jus. And before that, the starter, pictured above, was Penn Cove mussels with sweet onions, wild nettles, coconut milk, and ginger. Although not as bold as I generally like my food, the dishes were delightful, and the dining room a pleasant place to enjoy good company over a nice meal.
So what does Nell's dinner teach us about sex?It's all about the mussels. Or should I say muscles?
Rhubarb is a good source of potassium, Vitamin C, and calcium, all of which keep muscles strong and working well. Meanwhile, ginger is said to relax and soothe sore muscles. Celery does the same, while beef--full of protein, creatine, vitamins, and minerals--helps build muscles. As for mussels, well, aside from the word play, they have strong muscles, clamping onto external objects or clamping its shells together. Their muscles are important.
As are yours, for sex.
You'll find that working on your muscles can enhance your sex life. While the advice comes from Men's Health, both genders benefit by building muscles in the shoulders, triceps, chest, and back, as you'll be able to support your body weight when you're on top--or in other sexual positions. Similarly, for thrusting, you'll want to develop your abdominals and lower back muscles. Working out will also help with your flexibility and stamina, enabling you to be more creative and enduring in your sexual play.
Publications for women promote Kegel exercises, but both men and women can improve their sex lives by doing Kegels. More on this another time.
And, yes, you can actually build your muscles by having sex. Turning again to a publication for men, an AskMen.com article describes how various sexual positions (standing, partner on a table, and partner on top) provide the equivalent of a gym workout.
Of course, the brain is the most important muscle in the body, even in the area of sex. Mussels contain omega-3 fatty acids, Vitamin B12, and more that are healthy for the brain--which is all the more reason to eat mussels at Nell's.
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text:
For Tim Bigham
By Aletha Irby
I live in Hyde Park and am in fact one of that most Austin of
characters, a Hyde Park Poet. Well before the sun arises I wake
for my morning run. My 4 to 5:30 a.m. route takes me south down
Red River Street and through the University of Texas campus. Running
at this time allows me to encounter members of nocturnal tribes
I wouldn't normally see—possums, raccoons, bats, yellow-crested
night herons, pale pink geckos, toads, the occasional snake, and
moths the size of my right hand with wings like beaded moccasins.
Aletha Irby
my fiancé Tim asked me whether I ever see owls, I told him
never seen an owl in my life. He said I could start by learning to hear them.
We spent portions of several nights outside Hyde Park and Huntsville, and whenever
he heard an owl vocalize in the distance, he would call my attention to the sound.
As a result I began to be able to hear owls during my early morning runs. They
seemed to be all around me.
The first owl I saw was small and brown though she
had an impressive wingspan. She alighted in a live oak tree by
the fine arts building on the University of
Texas campus, across the street from the Texas Memorial Museum. Inspired by Tim,
who speaks to birds in their own languages and to whom birds respond in kind,
I stopped under the large old tree and hooted at her. But she behaved as if the
sound hurt her ears, and after shaking her head in distaste, flew away.
I was disappointed but when I peered up into the other thick branches
of the same live oak tree, I saw eight other owls of her kind staring
down at me. It was an odd feeling to go in a split-second from
never having seen an owl to being surrounded by an entire clan
of them. I had never been so glad in my life that I wasn't
a field mouse. Though they weren't large owls, I was intimidated
by their numbers, and continued my run without any further attempt
at communication.
However a few days later I heard another owl—this
one a male—vocalize just above my head as I ran under the same
tree. Stopping, I looked up at him—he
was perched on a low branch in plain view. I hooted at him, he hooted at me,
and I hooted back at him, and continued in that manner for some time in a polite
exchange, each of us taking our turns, neither interrupting the other.
the following days of summer, the same owl continued to afford
me much hooting practice. I got the distinct impression that I
provided entertainment
for him. I did not know what kind of owl he was until I consulted my "Stokes
Field Guide to Birds." Under the photograph which most resembled my owl
was a telling statement: "[The] Saw-whet is sometimes incredibly tame." I
thought about that statement further during the owlish early mornings, and determined
that a more accurate statement might be, "Some saw-whet owls surprise us
with their intelligence and openness to interspecies interaction."
One morning
as I ran down the sidewalk west of the UT Fine Arts Library, I heard a double
hoot behind me and half-turned my head, my peripheral vision just catching
a wide flash of brown wings alighted in the tree under which I'd just
run. Assuming I was witnessing a clan of saw-whets behind me interacting with
another, I continued running when I heard a second vocalization, and saw the
same brown wings gliding into the next tree under which I'd passed. Finally
occurring to me that it might be my saw-whet, I stopped and walked back to
find him perched expectantly on a low branch as if awaiting another opportunity
tutor me in owl-speak. We enjoyed our normal lengthy conversation—I think
it covered even more time for him since I gathered that owl-time moves more
rapidly than human-time.
That an owl had been following me was a little eerie
but also delightful. I
felt like a child again, albeit in an Addams Family, Harry Potteresque sort
of way.
Mom, this owl followed me home. Can I keep him?
My saw-whet was fully aware
that in order for me to see him he must advertise his presence. His wings
were so silent in flight that the monarch butterflies
who wing south past my ears every Austin autumn are positively raucous in
Once, instead of vocalizing, he noiselessly dive-bombed
my Nikes, scaring the daylights out of me and almost causing me
to trip over my own two feet.
though, I did manage to spy him before he saw me as he perched on the UT
Music building's low square sign post facing away from me, his distinctive
silhouette almost cat-like.
When I look at Austin, when I think of Austin,
I will always think of the love of my life, Tim, teaching me to listen
to and to speak with owls, and
of the
magical saw-whet summer which ensued.
Monica Beckford's
full story
Read Sofia Harber Bowden's full
Read John Salazar's full story
Read Deb Kelt's full story
Gina Schrader's full story
Danny Camacho's full story
Read Writing Austin's Lives introduction
Photo: Marsha
Office of Public Affairs
P.O. Box Z
Austin, TX 78713
Fax 512-471-5812


text:
Volume 12, Number 5—May 2006
Tuberculosis Special Section
Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis
Table 1
|When a sample of culture positive isolates underwent resistance testing, this was a random sample of all cases.
|Additional variation incurred by sampling tuberculosis (TB) cases for resistance was incorporated into 95% confidence interval estimates and thus the weighting of studies in meta-analyses.
|Differential ascertainment of resistance is unlikely because most of the included studies were double-blinded and (for studies in which information was available) similar proportions of culture-positive TB cases from each group were tested.
|Latent infection with isoniazid-resistant TB was equally distributed between comparison groups.
|12 of 13 studies were comparisons of randomized groups; any latent infection with a resistant organism would likely be equally distributed between comparison groups. Any imbalance due to random error would be bidirectional and so would result in summary estimate of relative risk tending towards 1 (i.e., being underestimated).
|Risk for isoniazid-resistant TB resulting from recent infection was equally distributed between comparison groups.
|Similarly, any new infection with an isoniazid-resistant organism would likely be equally distributed between randomized groups. Any imbalance would similarly result in summary estimate of relative risk being underestimated.
1Current affiliation: Department of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
- Page created: January 12, 2012
- Page last updated: January 12, 2012
- Page last reviewed: January 12, 2012
- Centers for Disease Control and Prevention,
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
Office of the Director (OD)


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Unloved: Guilty Of Love –highly charged songs from David Holmes's new band
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text:
Lyrics/song texts are property and copyright of their owners and provided for educational purposes only.
N.B.C. Lyrics
N.B.C. Song Lyrics
This is the way it should sound
[Intro: Cam'Ron (Noreaga)]
Ya heard (what what)
Yo B, we don't even like half these f*ggot niggas anyway
(what what what)
I'm on my own muthaf**kin' wheel (yeah, what what what)
You know what I'm sayin'
The real sh*t, you know B
My black family (what what what)
Slick Finga (clah clah clah)
Harlem World eatin' (yeah yeah)
Charli Baltimore (what what what)
Nore (yeah yeah what what what)
Cam'Ron nigga (yeah yeah)
Killa Cam nigga (what what what)
Yeah yeah yeah yeah
Yo, all my rhymes - I rip it; the song had to clip it
The cats in the street, nearly killing over snippets
Birds gotta feed 'em bread, so he can eat her head
I'm almost 21, but I still pee in the bed
Had to flead the FED's, all be trife
And I got a crush on Edith (who, Archie's wife!)
Yo not monagomy, pornograhy
On the outside, like an apostrophe
Tell my girls, I really like photography
Snap shots naked, the wildest boss
First night, head whop, and our salads tossed
While you in a mean neon, I'm with Celine Dion
Throw her in the bed, she the next one I pee on
Say what b**ch
Phase two
Yeah yeah
What what what
What what
What what what
What what what
What what what
Split that ass yo
Split that ass
Yeah uh, what
Yo yo yo
Yo, N-O-R-E; f**k y'all, niggas get hurt
You know I rock a Soul Train wit' a Cam'Ron's shirt
Doin' cartwheels, all my niggas got Hot Wheels
You a double A-R god, the bluntiest
You know we throw away, blunts for my niggas that's dead
Pour a Law Liqour, drink a long ligga
Then again I never beat, for my nigga Digga
You know I got, navigators, so we won't get lost
N-O-R-E, these Queens niggas call me the Force
At the arraignment, Thugged Out
Undertainment, for the lawyer - f**k 'em and the judge saves it
And I - did every crime - nigga name it
[Charli Baltimore]
Fools ain't ever know, the ghetto's be the baddest click
Charli's Angels, tangle with Devil's - Advocate
Hoes mad cause our pussy's got the fattest clits
It's some status sh*t, how we gon' have a b**ch
Under pressure, the Un undress her
That's a tester, that's just the best flirt, to the best skirt
Ever make it to networks
Like N.B.C., N.O.R.E., B'More and Cam'Ron
Anything we put our hands on, soak up like a tampon, plan on
For puttin' out the hottest LP's
Since - shiiit yo, you gon' have to tell me
Cause this is hip hop, meneaja twat
And ya'll jealous cause what I'm f**kin' wit' the two hottest
Underground fellas, what!
[Chorus (Noreaga, Baltimore, Cam'Ron)]
Aiyyo Iraq, Harlem World, Philly, San Juan
Un-sh*t; N.O.R.E., Charli, Cam'Ron
Mansions, 6's, Richies, plan on
Cali, Houston, New York, jam on
Aiyyo Iraq, Harlem World, Philly, San Juan
Un-sh*t; N.O.R.E., Charli, Cam'Ron
Atlanta, Chi-Town, V.A., plan on
D.C., N.C., S.C., jam on
Yo, all on the ballers sh*t
Nore, but we could call a chick
Head is what we all could get, biggest to the smallest di*k
She gon' swallow all of it
Harlem gon' have a ball with that
After I get her pregnant, yo we goin' to the mall with it
Yeah nigga, you know the lie, f**k that b**ch
The only reason I don't kiss her, is cause she sucked his di*k
And I don't even trust, ourself bro, f**k dat hoe
Pussy stinkin' anyway, let her go
[Charli Baltimore]
Yo ya'll niggas stay f**kin' with them grimmy chicks
On the real though, I wonder where ya'll find these chicks
The rest is evident, I'm the type to split on niggas
But if they right, I'll f**k around and spit on niggas
And if they into that hot sh*t, I might let 'em hit my spot quick
But first they gotta pop sh*t
If not then they gettin' drop kicked
And I like 'em all, Black Jack ya'll
Near 21, all others gettin' cut cut
So be it, you see me!
[Chorus (Noreaga, Baltimore, Cam'Ron)]
Aiyyo Iraq, Harlem World, Philly, San Juan
Un-sh*t, N.O.R.E., Charli, Cam'Ron
Mansions, 6's, Richies, plan on
Cali, Houston, New York, jam on
Aye yo Iraq, Harlem World, Philly, San Juan
Un-sh*t, N.O.R.E., Charli, Cam'Ron
Atlanta, Chi-Town, V.A., plan on
D.C., N.C., S.C., jam on
[music till fade]
Dru Hill f/ Redman
Case and Joe
Jay-Z f/ Amil-lion, Ja Rule
Wu-Tang Clan
Slick Rick
Montell Jordan f/ Flesh-n-Bone, Monifah
Jon B.
Fat Joe f/ Terror Squad
Tray Deee f/ Jayo Felony, Daz Dillinger
Charli B f/ Cam'Ron, Noreaga
Terry Dexter
Kasino f/ Nite & Day
Too $hort
Chris Tucker
Lalo Schifrin
Chris Tucker and Jackie Chan
Chris Tucker
Chris Tucker
Chris Tucker
Ludacris f/ Nate Dogg
Brad Kane, Lea Salonga The Scientist
Johnette Napolitano & Danny Lohner Let It Go
Idina Menzel Do You Want To Build A Snowman?
Kristen Bell, Agatha LeeMonn and Katie Lopez Part of Your World
Jodi Benson Rolling In The Deep
Adele Summer Nights
John Travolta / Olivia Newton-John Colors of the Wind
Vanessa Williams Pokemon Theme
Billy Crawford My Favorite Things
Maria MORE ›