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Spaciousness, Comfort & Pool for up to 10 guests!Send to a friend
From $350 / night
Description from the owner
Description from the owner
Bedrooms: 5/
Bathrooms: 4/
Sleeps: 10/
Type: House
Big and comfortable strategically located home with private salt water swimming pool, media room, terraces, decks, gym and more. The best beaches in the island, two casinos, two golf courses, a water park, the Zoo, fast food and fine restaurants, grocery stores, shopping centers, movies, etc. are all within easy reach via good and safe roads (most 3 to 10 mins. away – beaches 20 to 50 mins. max)!
You'll love the beauty, cleanliness, comfort and spaciousness of the house, with its tastefully decorated areas both inside and outside. Five ample sleeping rooms, beds equipped with "Allerease" mattress and pillow covers, 4 bathrooms, two terraces, large fully equipped kitchen, laundry, BBQ, etc. High speed Wi-Fi all around the house, Cable TV, Wii game console, large 47" TV, a media room with 10 foot screen and over 300 DVD/BluRays plus Netflix and Amazon streaming videos, and more will provide plenty of entertainment for all when at home. You'll just love the large "L" shaped pool for you to enjoy privately, day and night! You'll find all you need – and we mean all! - to have a wonderful stay. It's like having a small personal resort just for you!
Rates are $350 per night from Monday to Thursday, and $450 per night from Friday to Monday and holidays, for a maximum of 10 adults/children and a baby. Minimum stay is 5 nights. Whole week is $2,500 off season. That's less than $36 per person per day in a group of 10! We offer a 10% discount after first week's extra nights. Positive ID, a deposit and a credit card for security deposit are required, and balance on arrival. Please, inquiry for availability as we don't post our bookings in the online calendar.
You have found a rare gem! See the pictures and reviews and verify for yourself! Write or call us NOW to secure your dates! We only accept a limited amount of bookings per year.TripAdvisor property ID 3800535 ...Read more
Spaciousness, Comfort & Pool for up to 10 guests! Mayaguez, Puerto Rico
Additional Location Information
The house is located in the outskirts of Mayagüez, in the western (and safest) coast of the island. (This map doesn't show the correct exact location). From it you can reach the Añasco beach in 20 minutes; Rincon's beaches in about 30 minutes; Boquerón, Buyé and Villa La Mela beaches in 40 minutes; Aguadilla beaches, Las Cascadas Water Park, and Punta Borinquen Golf course in about 35 minutes, all by good and safe roads. Mayagüez Resort (previously Mayagüez Hilton), and Holiday Inn both have good restaurants and a Casino and are 4 and 8 minutes away, respectively. Other great restaurants are from 7 to 20 minutes away! Fast food restaurants, movies, jogging tracks and shopping centers are also very close by. The historic city of San Germán is just 30 minutes away with beautiful streets, interesting architecture, and the oldest church in the New World, now a religious art museum. The Club Deportivo Golf course is 25 minutes away. This certainly is an ideal location to use as a base to visit the portions of the island those who stay in San Juan never get to see, but if you want to go there it is less than 2½ hours away! You'll feel very comfortable and relaxed with the spaciousness of this wonderful property and its surroundings, as opposed to others where everything is cramped. It enjoys much privacy, safety and quietness as it is located in a cul-de-sac. Your best choice… undoubtedly!
More About This Location
Rural retreats, Warm winter getaways
How to get there
Car is not necessary
Rates shown in $ USD
|Minimum Stay
Please note: these rates exclude taxes and fees and may vary depending on the length of your stay. Rates are also subject to change at the owner's discretion.
Additional notes from the owner
Minimum stay is 5 nights. Extra nights after first week have a 10% discount (off season). A $150 fee will be added for special holidays like: Xmas eve, New Year's eve, July 4, etc. Positive ID, a deposit for reservation, a credit card for security deposit and full payment is required on arrival. Credit Cards or Paypal for deposit, and cash or traveler checks only for balance. Please, be advised that there is a 7% room tax for all stays in PR. Although we provide 5 bedrooms you only pay it ONCE.
Additional fees may apply:
- Discount | 10% of rent | The first whole week already has a $250 discount. Additional days after first week receive a 10% discount.
- A/C or climate control
- Towels Provided
- Hair dryer
- Linens Provided
- Soap/Shampoo Provided
- Alarm Clock
- Ceiling Fans
- Iron
- Local Guides/Maps
- Fitness Room
- Clothes Dryer
- Washing Machine
- Internet Access
- Hot Tub/Jacuzzi
- Private outdoor pool (unheated)
- Secure parking space
- Parking
- Toaster
- Paper Towels Provided
- Refrigerator
- Blender
- Microwave
- Stove or Oven
- Kettle
- Grill
- Satellite or cable TV
- DVD Player
- Television
- Books
- Stereo or CD player
- Garden
- Garage
- Deck
- Balcony or terrace
- Outdoor Dining Area
- Patio
- Pet
- Suitable for the elderly
- Smoking
- Wheelchair accessible
- children
- 4000 square feet
Reviews (13)
based on 13 reviews
Very good
Thrive Vineyard Church
There is only one word to describe the experience: amazing!
The accommodations are an exceptional value for the price. It is do refreshing to stay in a home like environment while traveling. The house is beautiful, spacious, and well kept. We are extremely grateful to have free use if everything in the house. Your graciousness and hospitality are exceptional.
We were very blessed to be made aware of your wonderful home. We hope we are fortunate enough to stay again.
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Recommended for: Luxury, Romantic
Response from the , Luciano Quinones - 02/12/2014
Thank you for your nice review and kind words toward us. It was a real pleasure having your church's group stay with us for the third time (counting the stay of the group from Miami)! You are welcome anytime!
R Lemay
"Beautiful home, great times!"
We had a great 7 days in this beautiful home over the Christmas holiday. The house is well appointed, esthetically decorated, warm and it is as big as it is described. My wife and I, three of our married children and their spouses, my youngest son and our granddaughter shared this home and found it welcoming, comfortable and spacious. There were enough bedrooms, beds and bathrooms for everyone. We spent a considerable amount of time on the covered patio and in the pool.
Mayaguez has everything one can need, and there are beautiful beaches with a 30 minutes drive. Traffic is heavy at times, but all in all, everything is within easy reach.
A final word on the owners. Luciano and Elsie Quinones were excellent and helpful hosts, and were easily available by phone for any question we had.
We certainly hope to return. Our family had a great time together, and this beautiful house was one of the reason's our holiday was a success.
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Response from the , Luciano Quinones - 01/10/2014
Dear Mr. Lemay,
Thank you for your nice review and for validating the points we mention in the house's information. It was a real pleasure having you and your beautiful family as our guests. It was an added bonus that your daughter is a pianist and we could share, although briefly, our mutual interest. We certainly hope that you come back some time.
Liz P.
"Amazing stay in a great location"
First, the house is very beautiful both outside and inside, and located in a very safe and quiet neighborhood, with easy access to most of the things you usually need. It is very spacious, airy and nice. Most of the rooms are extra big, with nice beds, mirrors, closets and even a chair in each one. Clean good quality bed sheets, bath and pool towels were provided. The kitchen is extra spacious and very well equipped with everything needed to prepare meals. The laundry is also fully equipped.
We especially enjoyed the covered terrace near the pool where we prepared Bbq's and played cards in the sitting areas, while the kids enjoyed the pool (and they did!). The patio has beautiful gardens with tropical plants, and even a hammock in a nice shady corner. There is an open terrace where we spent some romantic time at nights, as it connects with the master room and the weather was inviting. The house was a perfect size for the 10 of us, with enough room for everyone to spread out and be comfortable.
Restaurants, shopping centers, movies, historic downtown, and even two casinos were super accessible through a mile long connector to the main highway, all less than a 10 minutes' drive. Most of the beaches are around 30 minutes away. We especially enjoyed Boquerón's village, where you can buy clams at little kiosks, or fairly priced drinks at the local pubs, and mingle with people walking leisurely on their bathing suits on the streets. The beach there is very calm... like a lake! Very relaxing, with its beautiful golden sand and lots of palm trees. You can keep going from there and visit El Combate which also has a nice village and beach, and El Faro (old lighthouse) passing a salt lake, beautiful eroded rocks with a spectacular view, and another wonderful beach at the southernmost corner of the island.
Luciano was a great host, seeing that everything was Ok from the beginning. We would definitely go back and recommend this villa to anybody vacationing in PR.
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Recommended for: Luxury, Rugged, Romantic
Response from the , Luciano Quinones - 12/11/2013
Thank you for your nice review. You almost didn't left anything unsaid. We are very proud of our home, which we also live in, and are very glad to share it with travelers like you. We are also very proud of our city and our area, and like pointing out the good places so our visitors can enjoy it as we do. It was wonderful having you as our guests and hope to have you back soon.
A FlipKey verified reviewer
"Peace of Mind"
In choosing our accommodations for this trip our main selling points were safety, spaciousness, privacy, and family friendly. The home is located on the safest part of the Island, surrounded by tall walls, fences and homes of equal value. Located on a quiet cul-de-sac, it eliminated cars and unnecessary traffic. No loud neighbors. There was never a time we felt our safety was in jeopardy. Of course, common sense and street smarts are well needed. Because my mom would be traveling with us we needed to make sure her comfort and well being was taken into consideration. We also have a son with asperger's making social situations a little awkward for him. We were worried about busy hotels and cramped rooms. Renting this home provided my children (and us)time to relax and wind down without having to worry about other tourists. They could go to the pool and splash and just be kids without having to worry about other people. The pool was gorgeous and along with the spacious terrace it provided the perfect setting for family gatherings. The kitchen was very spacious and stocked with everything you need to cook meals. There was no oven, but we knew that ahead of time. A small conventional oven would be a great addition. The home was spacious, wide open, bright and sunny. The bedrooms upstairs were air conditioned. The one bedroom that didn't have a/C is located downstairs which was already cooler than the rest of the house, so all you really needed was a fan! The soothing sounds from the indoor pond made for some heavenly sleep! The media room and internet access was a plus for us tech oriented families. There was plenty of beaches a short drive away. We drove all over the island, hitting major attractions every day without feeling we were far away from "home". Luciano was extremely hospitable. He waited for our arrival in the middle of the night and was readily available when we needed him. I would definitely rent this home again and recommend to other families.
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Recommended for: Luxury, Romantic
Response from the , Luciano Quinones - 07/30/2013
Thank you for your nice 5 Star review of our villa and for pointing out some of the niceties it has. I'm sure that your experience with us will be helpful to other guests looking for quality accommodations.
We always strive to keep ahead and have the best for our guests. I'm sorry you didn't notice we do have a small convection oven, located in the laundry, adjacent to the kitchen. We also got a brand new refrigerator to replace the old one. We keep working on our gardens so you have many pleasant places around the house where you can enjoy and relax.
We have received 5 star ratings in all of our reviews so far and we intend to keep it that way by providing the best accommodations, keeping them in top shape and give the best service to our guests for a hassle free vacation... as we like to have ourselves when we travel!
"Perfect for families"
Stayed at this house with some friends and their child. Four adults and five kids, all under 7 years old. Pool was perfect, house was spacious, in a safe area, and the little things (Netflix access, theater and movies, location close to stores) made it a great trip. You can tell Luciano loves Mayaguez and truly wants you to have an enjoyable stay.
Although the house and some of the applicances are not brand new, this was perfect for us as we would have been paranoid with our kids running around. We did not do much in the area as the pool was very relaxing and the blender worked well. We did go to a few beaches. Highly recommend Playa Sucia.
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This was my first visit to Puerto Rico and being in this home made it most memorable. My sincere appreciation to the owner who offered the best accomodations and was always available. Would love to revisit next year! Thank you.
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Recommended for: Romantic
Thrive Vineyard Church
"Really great house in awesome location"
We took a group of 10 people to Mayaguez for a church missions trip and stayed very comfortably in this house. We loved the spaciousness of the house (our Puerto Rican friends who visited said it was the largest house they had seen rental-wise), having multiple bathrooms, the huge kitchen, large covered outdoor patio with a gas grill, and the beautiful pool. If the weather would have been a little cooler, we would have used the fire pit also. The location is really hard to beat - major stores are around the corner essentially, but you're off the beaten path just enough to have some peace and quiet. We really enjoyed hanging out on the covered patio out back because of the warm PR breeze and how private it is in the back. We only went to the beach one day because the pool at the house was so relaxing! Luciano was great to deal with also and really wanted to make our stay great. We will be back to this house next time we're in Mayaguez!
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Response from the , Luciano Quinones - 03/26/2012
We really appreciate your nice review and the 5 stars rating! Also thank you for comfirming to possible guests our description of the home's amenities and the closenes of all the facilities. I appreciate your kind words toward me. It was a pleasure having you here and we hope to have you and your nice party back real soon. In fact, thanks to your recommendation, another congregation of your church already booked a stay here! Thanks!
"We had an excellent experience here!"
We loved the home. It was clean, well maintained and had almost everything that we needed.
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Recommended for: Luxury
The Brady Bunch
"Wonderful Family Vacation"
We had the opportunity to stay at this beautiful home over the 2011/2012 holiday. There were 9 of us altogether. Luciano was such a gracious host, he made us feel right at home in his home. The swimming pool was not quite finished when we got there so we did not have the added luxury of the pool but even still our stay was fabulous. It was very comfortable; we were able to have large family breakfasts before heading out for the day and large family dinners at home in the evenings. This home is within an accepatble proximity to the beaches, the mall, the zoo, about 25-30 minutes to Rincon where my son and brother-in-law went scuba diving. We even drove out to Batey Zipline for a fun adventure. The drive was almost an hour and a half but what a beautiful drive!! We made the trip twice in order to go back and take a tour at Gran Batey Coffee Farm, also well worth the drive. Heck, just the scenery is well worth the drive. The only down side at the house were some water pressure issues, the home is 40yrs old but Luciano has done a great job of remodeling. The home definitely has a lived in feel versus feeling like you are in a museum. I would stay here again, especially now with the added bonus of the pool.
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Response from the , Luciano Quinones - 02/27/2012
Thank you for your nice review. I appreciate your kind words toward my person, and mentioning that we are located at a reasonable proximity to the beaches and other attractions, so others can verify it. Regarding the water pressure issue, it was just that the water heater was new and had a pressure regulator that somebody moved to a wrong position. We do have a 600 galons reserve tank and a pump that delivers 60 lbs of pressure, and everything is working fine now. We are sorry that inconvenienced you, but that problem is out of the way now! I'm also sorry that your stay was during the pool's construction, which may have inconvenienced you somehow and didn't present the house in its best shape.
"An excellent choice!"
We are two families with kids who joined together for a vacation. We are very happy for having selected this home. It was all we expected and more. The house's areas are big and airy, and everything was very clean and in good condition. The bedrooms are very comfortable and we were provided with good quality linens, towels, etc. We had Bbq's in the terrace while sharing with our children. The whole family particularly enjoyed the magnificent big screen home theater in the lower level.
The neighborhood is very nice and safe, and it was an excellent location to enjoy both the beaches of Rincón as well as Cabo Rojo. It was also very close to the zoo, and to other attractions for the children. The owner's recommendation of restaurants and places to visit were very helpful. We'll definitely rent it again whenever we vacation in that part of the island.
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Would you recommend this vacation rental to a friend? Yes
Recommended for: Friends, Groups, Tourists, Families w teenagers, Rugged, Romantic, Families w children, Singles, Luxury
"Exceeded our expectations"
This home has everything you will need and then some. We like to travel and visit friends, and we just felt like some very good friends had left us their super-sized place all to ourselves. Everything was as described. The owner is really friendly and courteous. The location is excellent, having beautiful beaches, great restaurants, and many other goodies within a short driving distance. Free Wi-Fi, impressive home theater, spacious kitchen, a beautiful backyard, home gym. I couldn't ask for anything else. We will be going back.
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Would you recommend this vacation rental to a friend? Yes
Recommended for: Friends, Groups, Tourists, Families w teenagers, Families w children, Luxury
A FlipKey verified reviewer
""Comfort Par Excellance""
The House was as seen on website. The neighourhood was ultra modern and quiet and located in a cul-de-sac,equipped with alarm and we felt safe. Upon arrival you could see the pride and joy in the well kept home and that a lot of time was put into making visitors welcome and comfortable
True to the owners word, all locations were accruately described and close by.
The house was airy, open design concept and spacious. Each bedroom was tastefully decorated and comfortable.The master-bedroom was my favorite with a Jacuzzi and terrace leading from the bedroom,adequate his and hers walking closets. We were provided with towells, soap, shampoo etc and all the conveniences of home.
Large well equipped Kitchen and dining area the only missing item was an oven. We thoroughly enjoyed the back porch and utilized the bar-b-que grill. The gardens were well kept and had a serene feel when relaxing on the porch.
There is a wonderfully well equipped Theatre room with tons of movies to choose from. There was a detailed house manual, which provided guidance on how to use equipments, Wifi,theatre system, fans, you name it. We were provided with maps of major places of interest and how to navigate our way around Mayaguez.
There was no need to call the owner.
I enjoyed our stay and would definately make a return to Luciano's home.
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Response from the , Luciano Quinones - 07/14/2011
Thank you for your nice comments. You are right: we care about our customers and put great efforts in keeping the property in top shape so that their experience is as good or better than expected. It is also our home and we feel very proud of it, for all its facilities and well designed areas. You say that the only missing item was an oven, and I'm sorry to say that it was just that you missed it, as there is a microwave unit in the kitchen and a convection one in the adjacent laundry room (they are mentioned in the house manual, but I'll put a sign on the convection one which I guess is the one you missed). Even with that you gave us 5 stars, so now you know that we really deserve them! I thank you for your nice comments and hope they help others come and enjoy all the comfort and convenience of our wonderful home.
A FlipKey verified reviewer
Hildrizhausen (Germany / Barcelona (Spain)
"Estancia maravillosa en Puerto Rico"
Somos alemanes con residencia en España.
El año pasado decidimos viajar a Puerto Rico. Por recomendación de unos amigos, nos pusimos en contacto con el señor Quiñones. La recepción fue simplemente fantástica: Flores, frutas del país, la mejor piña colada del mundo y un caluroso abrazo de bienvenida por parte del señor Quiñones. El estado de la casa, de las habitaciones, los servicios, la cocina, el jardín, etc., impecables. Limpieza e higiene absoluta. Equipamiento completo. La relación precio/calidad es óptima. La casa tiene acceso casi inmediato a la red de autovías del país. El Sr. Quiñones nos hizo interesantes recomendaciones y, a través de sus indicaciones, hicimos un recorrido inolvidable por toda la Isla, visitando no solo lugares que no aparecen en las guías turísticas sino también fantástidos restaurantes populares con toda clase de productos autóctonos. Ha sido una estancia inolvidable que pensamos repetir, claro está, en casa del señor Quiñones.
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Response from the , Luciano Quinones - 05/11/2011
¡Muchas gracias, Sr. Blanari! Para nosotros es muy importante la satisfacción de nuestros visitantes y nos esmeramos en lograrlo. Nuestra política es que nuestros huéspedes reciban el trato que personalmente deseamos recibir cuando viajamos. Y si hay sorpresas, que sean todas positivas. Le agradecemos sus generosos comentarios y esperamos con mucha anticipación su pronto regreso para brindarle a usted y sus acompañantes tan buenas atenciones como las de su visita anterior.
"Marvelous stay in Puerto Rico"
We are Germans established in Spain. Last year we decided to travel to Puerto Rico. Following a friend's recomendation, we contacted Mr. Quiñones. The reception was simply fantastic: Flowers, local fruits, and the best "Piña colada" in the whole world. The state of the house, the bedrooms, the bathrooms, the kitchen, the garden, etc... impeccable. Absolute cleanliness and hygiene. Fully equipped. The price/quality ratio is optimum. The house has almost immediate access to the country's highway network. Mr. Quiñones gave us interesting recommendations, and thru his indications, we had an unforgetable trip around the whole island, visiting not only places that are not listed in the tourist guides, but fantastic restaurants with all kind of typical offerings. It was an unforgetable stay that we intend to repeat, of course, at Mr. Quiñones' house.
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text:
Bush Withholds Documents in Attorneys Dispute
White House Memo
As promised, the White House has formally invoked executive privilege in a dispute with Congress over the controversy involving the firing of U.S. attorneys last year.
In a letter to Sen. Patrick Leahy (D-VT) and Rep. John Conyers (D-MI) — the chairmen of the Senate and House Judiciary Committees — the Bush administration said that it will not submit e-mails and other documents regarding the dismissal of eight federal prosecutors.
Writing on behalf of President Bush, Fred F. Fielding, the counsel to the president, said "that it is incorrect to say that the President's assertion of Executive Privilege was performed without 'good faith.'"
The memo also argued that promises from the judiciary committees to enforce their subpoenas "'[w]hether or not [they] have the benefit of the information'" suggests that the panels "have already prejudged the question, regardless of the production of any privilege log."
Fielding also extended the president's "request that further interbranch relations in this matter be distinguished by respect for the constitutional principles of both institutions and marked by a presumption of goodwill on all sides."
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text:
Saya Narita is a cock hungry babe who just can??t get enough! She has a partner who enjoys licking her feet and she shows her white panties as he is playing with her toes before moving on to better things like sex! She gets her panties off and shows off her hairy cunt as she is lowering herself onto his hard cock for a hobby ride. Tiring of that, he moves to licking her hairy slit to turn her on more before going back to sticking his cock in her to finish off by shooting his load inside her.
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text:
| Tiger Rant
| Alex Edward Homerun Ball--Updated--FOUND - Ranty Randy on 5/21/10 at 9:31 am
Kudos to Alex Edward for his first ever LSU homerun last night with hopefully many more to follow. Alex has a relative who went and tried to find his homerun ball last night for about 30 minutes right after it happened. The ball sailed between the left field bleachers and the batter's eye. It app...View Topic - Replies (7)
| Tiger Rant
| A Good Short Story About LSU Fans - Ranty Randy on 9/30/09 at 10:36 am
I had a tentative trip planned to Starkville for the game last week that didn't come through, so I called a friend of mine in Mississippi to see if he wanted the tickets. He is an LSU fan. He said that he wanted the tickets, so I sent them to him. Come to find out, his granddaughter, who is a b...View Topic - Replies (3)
| Tiger Rant
| Duane DeArmond-Former LSU Basketball Player-Funeral Info - Ranty Randy on 2/18/09 at 11:44 am
Tigernation, To all who are not familiar with the situation, former LSU basketball player Duane DeArmond who played back in the late 70s with Rudy Macklin, Jordy, Scales, etc. was diagnosed with cancer back in August. I started a thread about him then. He was better known as Disco D. Since he ...View Topic - Replies (12)
| Tiger Rant
| Former LSU Basketball Player Needs Your Prayers--UPDATE 9-19 - Ranty Randy on 8/11/08 at 4:59 pm
My best friend and former LSU basketball player, Duane DeArmond, has been diagnosed with cancer. For those of you that aren't aware, he played for the tigers from 1976-1980 back in the glory days with Rudy Macklin, Greg Cook, Jordy Hultberg, and the rest of the gang. He carried the nickname of Dis...View Topic - Replies (38)
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Aqua Waikiki Pearl, Honolulu
- Free WiFi
Main amenities
- 131 smoke-free guestrooms
- Near the beach
- Bar/lounge
- Self parking
- 24-hour front desk
- Air conditioning
- Daily housekeeping
- Convenience store
- ATM/banking services
- Laundry service
- Gift shops/newsstands
- Free newspapers in the lobby
What's around
- In Waikiki
- Honolulu Zoo (0.7 mi / 1.1 km)
- Waikiki Aquarium (1.1 mi / 1.7 km)
- Ala Moana Center (1.6 mi / 2.6 km)
- University of Hawaii at Manoa (2.4 mi / 3.9 km)
- Diamond Head (2.8 mi / 4.5 km)
Aqua Waikiki Pearl, Honolulu
Hotel Info: 866-539-8117from $87
- Suite, 3 Bedrooms, Kitchen
- Standard Room, 1 King Bed
- Standard Double Room
- Suite, 2 Bedrooms, Kitchen
- Junior Suite
- Suite, 1 Bedroom, Kitchen
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 131 rooms
- This hotel is arranged over 10 floors
- Check-in time starts at 3 PM
- Check-out time is noon
Required at check in
- Credit card deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed (dogs only) *
- Specific rooms only, restrictions apply *
- 2 per room (up to 18 kg)
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Self parking (limited) *
Other information
- Smoke-free property
Nearby Two Star Honolulu hotels
In the hotel
- Bar/lounge
- Free reception
- Use of nearby fitness center (discount)
- Bicycle rentals nearby
- Golfing nearby
- Hiking/biking trails nearby
- Scooter/moped rentals nearby
- Snorkeling nearby
- Surfing/boogie boarding nearby
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free newspapers in lobby
- Luggage storage
- Number of buildings/towers - 1
- Elevator/lift
- ATM/banking
- Accessible bathroom
In the room
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
- Blackout drapes/curtains
- Private bathroom
- Free toiletries
- Hair dryer
- Cable TV channels
- Free newspaper
- Free WiFi
- Free local calls
- Refrigerator
- Microwave
- Daily housekeeping
- In-room safe
Top Honolulu hotels
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- New Otani Kaimana Beach HotelFrom
"Staff is very nice. The hotel is right on a very nice beach for swimming snorkeling and advanced paddle boarding. "Apr 22, 2016
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"A nice stay had by all . The staff was friendly , the room was clean , small breakfast and coffee offered . Shopping available all around you no matter your price limit , the…"Apr 21, 2016
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"It was the best experience I've had in along time. Everyone from the time I checked in at 9:30 pm til the time I checked out at 5 am the following week was were so kind and…"Apr 21, 2016
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"I loved the room. the view was excellent, we didn't have a beach view it was city view but it was perfect especially in the night. we were 2 blocks from the beach, The room was…"Apr 21, 2016
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Rollaway beds (surcharge) and cribs (surcharge) should be requested at time of booking.
Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation.
Parking height restrictions apply.
Mandatory fees
You'll be asked to pay the following charges at check in or check out:
Pet deposit: USD 100 per stay
- Resort fee: USD 15 per accommodation, per night
Resort fee inclusions:
- Beach loungers
- Beach towels
- Shuttle service
- Internet access (may be limited)
- Newspaper
- Phone calls (may be limited)
- In-room safe
- Lending library access
- Additional inclusions
Inclusions may be listed elsewhere on the page as free or for a surcharge.
Optional extras
Self parking costs USD 26 per night
Cribs/Infant beds are available for USD 25 per night
Pets are allowed for an extra charge of USD 35 per pet, per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
Rockefeller Center, 7th Floor, 1230 Avenue of the Americas
New York, NY 10020
Phone: (630) 697-1315
Fax: (630) 303-9706
Contact: Jeff Nauman , Manager - Channel Sales
Email: email@example.com
NRF Associate Member
iVend Loyalty
iVend Loyalty is a points & rewards management application designed to significantly improve customer retention by bringing them continuously back and at the same time improve customer satisfaction levels. iVend Loyalty is seamlessly integrated with iVend Retail and can integrate with any Business Management or Retail application using the universal and platform neutral web services based APIs. Flexible Loyalty Plans with multiple redemption features make iVend Loyalty an imperative solution not only for the Retail Industry, but also for non-consumer industries like manufacturing and not-for-profit organizations.
Target Retailer/Client:All Retailers
Hardware Platforms:Windows OS- 64bit, 32bit
Operating Systems:Microsoft Windows
Software Group:Client Server Vendors; Microsoft Windows Vendors
Number of Retail Clients:1000
Remote Access:No
Programming Language:C#3.5 (.Net framework 3.5 SP1)
Database Name:SQL Server 2005/2008
Number of Installs:N/A
Year Introduced:2011
Representative Clients:
Direct Support:Yes
3rd Party Support:No
3rd Party Interface:No
Interface To Whom:N/A
Web Demo:Yes
Geographic Areas Sold:Africa; Asia; Australia/New Zealand; Europe; Latin America; North America; South America; United Kingdom; United States
Annual Retail Sales - Target Customer:All Groups
ARTS (Association for Retail Technology Standards) Compliance:ARTS Retail Data Model: No
Unified Point of Service (UnifiedPOS): No
ARTS XML Standard XML Schemas: No
Application Functions
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text:
Santa Claus Daisy by chacckcoWatch
©2013-2016 chacckco
Merry Christmas!!
Nice! ^^
Very Nice ^^
She's so sexy duck XD I love your art work!
Merry Christmas!!!!
Merry Christmas
yay!! Merry Christmas!!
que linda Daisy!!<3
Se ve muy linda! Feliz Navidad y un buen año Nuevo!
She looks very pretty! Merry Christmas and a good new year!
That is one foxy duck.
Merry Christmas!
merry Christmas
¡¡¡Feliz Navidad!!!
hehe ^^ wow, nicely done ^^
wow she is soo pretty in chrismas suit. it suits her. her shape looks very nice. ;3 Merry Christmas & Happy New Year!
Very nice.
awesome job there, chacckco
She looks awesome!
I really love Daisy and I admire this picture!
Good job!
She looks great, but her spine confuses me.
I think it's because Daisy had really fluffy tail-feathers, so the dress lying over top of them made it look a little weird.
You're not alone. Confuses the heck out of me too.
Gosh I adore it! You made Daisy look fabulous. Awesome.
Mind if I color it, and credit you?


text:
Syneron's Elure™ Wins Allure Magazine's BEST OF BEAUTY Award For The Second Consecutive Year
Israel, Sept. 18, 2012 /PRNewswire/ -- Syneron Medical (NASDAQ: ELOS), www.syneron.com, the global leader in medical aesthetic products and technology, announced today that Allure Magazine has named elure™ Lotion its "Best Anti-Ager for Discoloration" in its annual Best of Beauty issue, which is published in October every year. This is the second consecutive win for elure in Allure Magazine's Best of Beauty issue; elure™ Lotion and the elure™ Night Cream won the coveted award in the Big Breakthroughs category in October 2011. (Logo: http://photos.prnewswire.com/prnh/20120528/535447)Allure Magazine selects their winners based on real, noticeable results. Among the thousands of beauty products launched every year, "these are the products that truly deliver," the magazine says, noting that elure Lotion is one of the only products readers need to know and own. Louis Scafuri, Chief Executive Officer of Syneron, commented, "Due to its outstanding efficacy and safety profile, elure has rapidly become a leading home use solution recommended by physicians around the world for correcting skin discoloration. We are thrilled and honored to receive this award from the leading beauty experts at Allure Magazine." In addition to the Best of Beauty award, Allure Magazine also named elure Lotion one of "50 Beauty Products to Buy Before You Die". Hailed as a "powerful skin-brightening cream," by Allure, dermatologist Leslie Baumann, M.D., a member of Syneron's Medical Advisory Board said, "my patients are seeing their hyperpigmentation fade within four weeks." "elure is safe, simple-to-use and works well on all skin types," states Anne Chapas, M.D., dermatologist and Medical Director for Union Square Laser Dermatology in Manhattan, New York. "Patients rightfully are enthusiastic when they experience quick results without irritation. Within a month of regular use, skin appears brighter and more even toned." See elure Lotion's Best of Beauty award for "Best Anti-Ager for Discoloration" in Allure Magazine's October 2012 issue. See elure Lotion highlighted as one of Allure Magazine's "50 Beauty Products to Buy Before You Die" here: http://www.allure.com/beauty-products/2012/beauty-products-to-buy-before-you-die#slide=44 For more information about elure's full range of products visit www.elureskin.com or follow us on Facebook: http://www.facebook.com/elureskin. About Syneron Medical Ltd. Syneron Medical Ltd. – a company devoted to real technology, real science and real results – is the leading global aesthetic device company with a comprehensive product portfolio and a global distribution footprint. The Company's technology enables physicians to provide advanced solutions for a broad range of medical-aesthetic applications including body contouring, hair removal, wrinkle reduction, rejuvenation of the skin's appearance through the treatment of superficial benign vascular and pigmented lesions, and the treatment of acne, leg veins and cellulite. The Company sells its products under two distinct brands, Syneron and Candela. With its innovative approach to aesthetic treatments, Syneron has now entered into one of the largest in-demand applications, skin lightening. Founded in 2000, the corporate, R&D, and manufacturing headquarters for Syneron Medical Ltd. are located in Israel. Syneron also has R&D and manufacturing operations in the US. The company markets and services and supports its products in 86 countries. It has offices in North America, France, Germany, Italy, Portugal, Spain, UK, Australia, China, Japan, and Hong Kong and distributors worldwide. elure™ is sold as a topical cosmetic intended to beautify your skin and cosmetics are not subject to evaluation by the FDA. All product information provided is intended to be for informational purposes only. The information about skin conditions provided herein does not constitute medical or pharmaceutical advice and should not be relied upon as a substitute for qualified medical consultation with health professionals. Additional information can be found at www.syneron.com SOURCE Syneron Medical Ltd.
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text:
Sweetie-bot by ShadesofEverfreeWatch
©2012-2016 ShadesofEverfree
When I'm feeling broken down
She has always got my back
Life is worth protecting now
Something something giant hat!
She has always got my back
Life is worth protecting now
Something something giant hat!
This !! OMG, I LOVE IT !!
Why do people stare at me
is it my voice or walk
they say i sound weird
even when i began to talk
a scraping follows me
i turn around, nothing there.
whats weirder i know that
water frizzes up my hair
i'm a normal pon---y
maybe not rarit---y
i have magic
ill get my mark someday
even if it takes all summers and falls
im still a pony after all
I really like the way you did these!! Do you do OC wallpapers like these?
these are AWESOME!! could you do one of my oc?
I could do that. Link me a pic of your oc
Sweetie-bot is best robot.
I need one too!
You have arranged objects in an aesthetically pleasing manner.
I Love it!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
This looks cool!


text:
Weather Alert(1)!
Weather | LIRR | Traffic | Traffic Cams | Weather News
Oops!! The event you are looking for is expired. Check Live Events!
Annual Spring Flower and Garden Show at Hicks Nurseries
at Hicks NurseriesFri Mar 07 - Sun Mar 16
I'M GOING(3 members going)
Hicks Nurseries
100 Jericho Turnpike
Tel: 516-334-0066
Date & Time08:00 AM - 06:00 PM
Cost: Please call
Don't miss out on the Annual Spring Flower and Garden Show at Hicks Nurseries! Founded in 1853, Hicks Nurseries is the oldest nursery and garden center on Long Island. We feature a large selection of outdoor and indoor plants, flowers anmd accessories.


text:
Monday, 5 November 2012
Our weekend in Sydney
Morning Everyone! Tim & I have just had a fabulous weekend in Sydney without the children!
You might remember this post about our last trip to Sydney.
Things were ALOT more relaxed this time around!
It was a double celebration weekend, my friends baby is due in a month & she had a 'Bambino Celebrazione' and it was our wedding anniversary. I love parties with old friends . . .they are simply the best.
Double Bay is my favourite spot in Sydney. I love the streetscape with it's topiary trees and striped awnings. I love seeing gentlemen wearing ferragamos and drinking morning espressos. It's safe, it's pretty & it's old school. A highlight for me was the Double Bay festival on Sunday. It took us completely by surprise! Here are some snaps of my weekend & few little purchases.
New favourite shops include: Olivades, Mandalay Flowers and Maison Et Jardin. And of course Sydney Antique Centre.
And the markets were great! I ummed & ahhed about these vintage glasses. Do you ever try something on and think . . . .'Am I cool enough to pull these off!?' . . . .as a 31yr old Mother of two I find I am constantly asking myself this. Hemlines too short, earrings too dangly, fluro too bright . . . but I love these glasses and they fit nicely so they came home with us.
Henry & Alice had a weekend escape to Noosa . . . I do miss them this morning but it's hard to beat a sleep in until 7.30am.
I hope you guys had a fun weekend!
12 comments:
Those little birds nestled in the flowers are so gorgeous!!!ReplyDeleteReplies
Aren't they cute E.A.P & only $7.50 each! What is the saying . . if in doubt put a bird on it!? lovTDelete
T, can I just adopt your friends? And your husband, and kidlets? Can I, can I? What a fabulous weekend you had - full of the best things in life. Congrats on your wedding anniversary - it's still, hands down, the most ah-mazing wedding I've ever seen xReplyDeleteReplies
I've told you before . . .let's do a Freaky Friday & swap lives!! I have 100% committed . . .it's you that's dragging the chain my friend! lovTDelete
Sounds like a fabulous weekend - I hope you are having a little flutter on the races!ReplyDelete
Melissah from ScrapbookReplies
Thanks Melissa! I'm just no good at betting, what about you!? lovTDelete
Lovely photos Tina!ReplyDelete
Great to see you had such a wonderful time!
PS love the glasses! Jx
ninest123 07.15ReplyDelete
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text:
Reguested by for his favorite character in Claymore Anime, Ophelia. He requested to have her wearing an armor, so I make one that can be justified and not hinder the claymore's agility and sword skills.
Most of the armor design I got from Fire Emblem: Awakening. I great thanks for that awesome anime game. The armor shown in this artwork will be part of the side fiction I made with , named, "A Phantom's Trilogy".
"A Phantom's Trilogy", is a side fiction made for Claymore and in particular, with "Phantom Miria Trilogy", a story done by .
"A Phantom's Trilogy" is a claymore story focusing on the three hybrids, Chloey de Lupia, Miata Hapsburg, and Princesse Natalie de Beauharnais. The story includes mystery, parasitic monsters, and the mysterious organization, the Neo-Org.
For reading the stories we made, please visit this journal for links of the story:
Most of the armor design I got from Fire Emblem: Awakening. I great thanks for that awesome anime game. The armor shown in this artwork will be part of the side fiction I made with , named, "A Phantom's Trilogy".
"A Phantom's Trilogy", is a side fiction made for Claymore and in particular, with "Phantom Miria Trilogy", a story done by .
"A Phantom's Trilogy" is a claymore story focusing on the three hybrids, Chloey de Lupia, Miata Hapsburg, and Princesse Natalie de Beauharnais. The story includes mystery, parasitic monsters, and the mysterious organization, the Neo-Org.
For reading the stories we made, please visit this journal for links of the story:
Of course MortalsShinobi's the one who requested this!
lol looks great
lol looks great
Um didin't this character, die, partway thorugh the first section of the series.
This is phenomenal! I may not know the character in question but you manage to make this character's eyes show a genuine happiness and joy despite the lack of detail in the face. You put it in all the right places. Also your armor work is just the best. I really like it. This is definitely one my favorites.
I think I only make the artwork right just this time. Thanks very much for faving!!! I'll work to make the facial details. And I'm glad you like her armour as well!!!!
well, just started work on the colors for this one. so the full things should be up tomorrow or the day after i think.
I'll be waiting thn for the coloured version.
Perhaps you will love the character once you see her in full colours!!! Btw, this is :iconTheSilentChloey:'s work in colours:
I think you should draw her neck twisted, it's more anatomically correct that way.
I'll try to make another one of her with the same armour, adding this description you gave me, if I got the time.
Just remind me if I forgot to do it.
It was a joke duh <.<
Well, i thought it's a request.
I'm not into Claymore anymore, amen.
Well, I never realized it was you who actually replied with the twisted head, so sorry I just noticed you lately. I;m actually thought I'm talking to mortalshinobi, but I'm so sorry it was you who make it.
Ah, I thought you were temporarily insane.
Anyways, I made a comment on your sissy man using my comic's account: tracesofthepast.deviantart.com… , just to let you know it's me
Anyways, I made a comment on your sissy man using my comic's account: tracesofthepast.deviantart.com… , just to let you know it's me
I'm sorry, I'm really thought I'm talking to mortalshinobi. I had mistaken you for somebody else.
I see. So you're having other accounts then. But come' on, you know I'm not used in making male characters. So that one could be an exercise in making male characters with the correct male body features. I'm fortunate that you commented with it. It's really good for me that you give corrections of what I need to improve.
Hi!!!! ClaFanN1!!!
Her amour is in the way silly.
I wonder how much wasted potential claymores had to undergo not having barely any functionable and practical armor or defensive equipment...
That is one thing Yagi didn't think at all. Perhaps being a superhuman of the hybrids gives Yagi confidence that armor is not needed. But really, even being hybridized, a warrior needs armor. This is common sense, esp. if the armor used is that metal used in their swords. Remember that their swords didn't break or got a dent, while not use it in the armor?
Yes, females in very good armor that not only protects them but also shows them sexy is very charming. And I hate ornamental armour, armour that is there to be a decoration than protection.
Even so even basic Chainmail of a good alloy like that of their almost indestructable swords protecting the most important part that was COMPLETELY exposed ( the stomach chest area) but the effect of awakening does most of the time destroy their armor(that they do have) and their clothing but I mean even adult Raki suited up with Banded plate/leather armor
Btw, the artwork presents an armout suit without the belly armour. It is rather placed by a padded leather. Claymores can choose to add armour in their bellies.
Why not make an armor that allows body expansion at a certain stress (at least not being an awakened form whrer the armor joints will basically snap). But by assessment on the anime and even in manga, warriors never gets bigger in the torso area when trying to obtain heavy mass. The thing that usually change is the limbs, but the stomach and the chest remained the same.
Yes, at least chainmail or padded leather can give some matter of protection. Or perhaps a belly armour can work too (Ye, I make a belly armour version waiting to be posted. It is the same concept as to the artwork shown but with the addition of an armour in the belly area. I made it is a way that still didn't hamper movement and makes the wearer remain sexy and seductive looking). Belly armours with the metal like that of their sword will avoid that attacks Claire got in the first part of the story (Remember her being impaled by that hand of the youma, then Rubel said that such portions are vital and can kill a hybrid. Why not reinforce armour on such area?).
Exactly I was about to point that part of the story out as well. Its very unpractical that the only armored parts of their body was the forearms shoulders, hips, clavicals(neck area) and the feet and shins leaving all the organs and entire torso exposed for attack, Albiet the paladin dude who was buddies with the rogue his platemail was peirced by the veracious eater's extendable talons, but he survived it and he was just a normal(soldier) human and undoubtedly the armor took some of the force from an otherwise lethal blow.
Yes. It is a waste they made. To think they can afford to put armour in not so vital areas but cannot make a way to at least protect those vital parts exposed. I mean they should have those remove instead because the whole armour dressing is totally a piece of thrash considering where they place those things in the body. I still cannot think they cannot use the metal that made their swords, just amazing they can't. And remember that females have cumbersome weight in the chest...can they at least make a way to support those weights because I myself can think those things unsupported are really a nuisance to movement. I mean no woman today want their melons bouncing when they run, jog, or punch right. I see the illogical way the Org tries to portray not having their warriors attend that basic need.
I would have to agree with you on that one...I for one see mine as getting in the way a lot of the time...even with the use of brassiere they're still in the way >.>
Sorry for that, but at least I hit the point. I am hoping that at least an armour can hold the melons in placce while the hybrids are fighting. I don't want to get their melons hang loose because they didn't put brassiere in it. It's not nice to see loosed "melons" and they're not even yet mothers...they got it because of constant bouncing due to their profession as warriors.
Also it may be the fact that even making the swords was extremely difficult or expensive and making practical full body(but allowing good movement like Field plate armor) the in Manga(anime) Organization seen as a waste since they figured claymores as expendible soldiers or just temporary as they eventualy awakend
Well, that could be a good idea. but it defeats the purpose of looking for a potential super hybrid they eager to achieve if they neglect the very basic need of a soldier...protection. Or they are hoping that somehow, claymores will learn to rely not on armour. But if they can put armour in their shoulders and hip then it's very stupid enough not to put armour in the very vital human parts. I mean, they should have then remove those cumbersome metals in the shoulder or hip afterall if they are aiming for teaching the warriors not to depend on armour but on agility. Being even heavy makes agility reduced severely.
Well they also have the Dragonkin tribe they had to contend with and since they havent faught one we havent even seen how strong they are who knows? maybe even their "indestructable" swords can be damaged against the their hides or something.
At least they got descent armour than just a decoration. But now I don't know if what are the dragonkin's power now, considering that Yagi overpowered much of his characters in the island. What would these "dragons" could be capable with, destroying the whole world? I think he really overpowers his characters that dragonkins are expected to be either very strong, or a scapegoat talk just to give reason as to why there are hybrids. Well, they should have put Teresa of the Faint Smile or Priscilla in the mainland already.
nice XD I really love this I think that it really captures Ophelia physically and personality wise great job
Thanks very much!!! Actually, I find Ophelia hard to make because of her smile that is somewhat unique. It took me many references (from claymore fanart to the original artwork) to arrive to the better facial expression of her in this artwork.
WOW!!! I love it!!
Thanks!!! now, remember that talked we had that I show you videos of music, then I said that there is a picture of two poeple that I planned to get as reference for Chloey and Chris? I am planning to make them now.
oh nice! i'll have to color this when i have time.
i like the armor design and she looks cute!
i like the armor design and she looks cute!
Thanks!!! I am glad you like the armor. This will be the armor I'll use for hybrids because it seems that it fits to their agility and fighting skills. Of course, I intended Ophelia to be cute-looking and innocent because she is posing herself, like somebody shot a picture to her. But well, you can make her to her menacing look as she always gives to her victims.


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James B. Thompson: Fragments In Time
January 23 – March 26, 2016
Melvin Henderson-Rubio Gallery
James B. Thompson has been on the art faculty at Willamette since 1986, where he teaches painting, drawing, and printmaking. The exhibition will explore the development of Thompson's work during the past twenty years, from his Medieval and Golf Series of the mid to late 1990s and early 2000s to his most recent work that includes glass created at Bullseye Glass in Portland.
An Archaeologist's Eye: The Parthenon Drawings of Katherine A. Schwab
November 7, 2015 – January 31, 2016
Study Gallery and Print Study Center
Organized by the Bellarmine Museum of Art at Fairfield University in Connecticut, this exhibition features 35 drawings by Katherine A. Schwab, an archaeologist and professor of art history at Fairfield. This exhibition explores how Schwab has used unique drawing techniques as a fundamental component of her investigations in studying the east and north metopes of the Parthenon, a series of marble panels with relief sculpture which suffered devastating damage in post-Antiquity.
Stilleven: Contemporary Still Life
September 12 – December 20, 2015
Melvin Henderson-Rubio Gallery
Stilleven (the Dutch word for still life) features work by 27 contemporary artists from Oregon, Washington, Idaho, Montana, and British Columbia who focus on still life in their artwork. Organized by Director John Olbrantz and Collection Curator Jonathan Bucci, the exhibition includes paintings, sculpture, prints, drawings, photographs, glass, and mixed media by artists Katherine Ace, Holly Andres, David Giese, Norman Lundin, Flora Mace and Joey Kirkpatrick, Henk Pander, and Sherrie Wolf, among many others.
Sherrie Wolf: Object Lessons
August 1 – October 25, 2015
Study Gallery and Print Study Center
Sherrie Wolf is a Portland painter and printmaker whose work juxtaposes traditional still life subjects (bowls of fruit, floral arrangements) with Old Master themes. Organized by Director John Olbrantz, the exhibition features paintings, prints, and other works on paper by the artist drawn from private collections throughout the region.
Mel Katz: On and Off the Wall
June 6 – August 23, 2015
Melvin Henderson-Rubio Gallery
This major retrospective exhibition of Portland sculptor Mel Katz (American, b. 1932) chronicles the career of this prolific and dynamic artist who has played a prominent role in the Portland art scene for over 50 years. The exhibition features a veritable forest of Katz's large scale abstract geometric sculptures drawn from public and private collections throughout the Pacific Northwest, as well as a number of works from the artist's studio.
"Point of View"
May 12 – August 23, 2015
Landing to the second floor
In this new exhibition series, we invite members of the Willamette community to share their experience or interpretation of a work of art from the perspective of their area of expertise, study, or research. Each semester we will offer a new work, and a new "point of view."
Mel Katz: Drawings and Small Sculptures
May 9 – July 19, 2015
Study Gallery
This exhibition has been organized to introduce visitors to Portland artist Mel Katz's working process and is intended to supplement a fifty-year retrospective exhibition Mel Katz: On and Off the Wall taking place at the Hallie Ford Museum of Art between June 6 and August 23.
Drawing has always been an important part of Portland artist Mel Katz's working process. This exhibition features several of Katz's large scale drawings and small sculptures that he uses to work out some of the complex visual problems and challenges that he deals with in his final sculptures and offers valuable insights into the artist's creative process.
Tom Prochaska and Christy Wyckoff: In the Footsteps of Charles Heaney
May 9 – July 19, 2015
Print Study Gallery
During September of 2014, Portland artists Tom Prochaska and Christy Wyckoff embarked on a journey to retrace the footsteps of Portland painter Charles Heaney (1897-1981), who often traveled to remote regions of Eastern Oregon in search of artistic inspiration. The exhibition will feature approximately 30 drawings created by the artists' during their recent road trip.
"Senior Art Show 2015"
April 18 – May 17, 2015
Melvin Henderson-Rubio Gallery
Each spring, the Hallie Ford Museum of Art features the work of senior art majors at Willamette University. The exhibition represents the culmination of their four years at Willamette.
Characterized by a wide variety of styles and approaches, the exhibition will feature work in a variety of media, including painting, drawing, photography, sculpture and mixed media. In addition, many of the senior art majors will discuss their work as part of free Tuesday gallery talks during the first three weeks of the exhibition.
"Alexandra Opie: Echo"
April 18 – May 17, 2015
Atrium Gallery
Alexandra Opie is an associate professor of art at Willamette University, where she teaches photography and electronic media. An exhibition of her recent work opens April 18 and continues through May 17, 2015, in the Atrium Gallery. The exhibition features a range of tintype photographs created by the artist during the past two years that explores early portrait photography techniques within a contemporary context.


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Brand: Dashing Tweeds
Beginning in April, the Museum of the Rhode Island School of Design in the US will be holding an exhibition of clothing drawn from its archives and borrowed from sources around the world – including our own, inimitable Guy Hills and … > Read more
The recent Best of Britannia exhibition in London showcased small, craft-based British companies making everything from kitchen knives to bicycles. It included some Permanent Style favourites such as Hiut jeans, Dashing Tweeds and the various west-country makers grouped under the … > Read more
You must know Guy Hills. No one who has ever seen him in his full Dashing Tweeds cycling around London could ever forget him. In a recent photo feature in Esquire's Big Black Book on personalities around Mayfair, there were … > Read more
Luxury is not defined by price, quality or comfort. Luxury is simply what you don't have. Or, more precisely, what you aspire to. Generally, it is that which others have or you once had. So, obviously, what is considered luxurious … > Read more
My tailoring is taking a step up in the world. I'm having my first English bespoke suit made. The tailor is Graham Browne, whom I have written about on this blog previously. They are located on Well Court, just off … > Read more
Good tailors for adjustments to suits, trousers and shirts are not always easy to find. There is a raft of pretty poor establishments dotted around London, staffed by dressmakers or general tailors with no specific experience of men's tailoring.For the … > Read more


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Anshul Gupte
University of Kentucky, Lexington, Kentucky, United States
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Development of Idarubicin and Doxorubicin Solid Lipid Nanoparticles to Overcome Pgp-Mediated Multiple Drug Resistance in Leukemia
Ping Ma
Xiaowei Dong
Courtney L Swadley
· Anshul Gupte ·
Markos Leggas
Harry C Ledebur
Russell J Mumper
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The objectives of these studies were to investigate and compare solid lipid nanoparticles (SLNs) of two anthracyclines, idarubicin (IDA) and doxorubicin (DOX), against Pgp-mediated multiple drug resistance (MDR) in-vitro and in-vivo using different human and murine cancer cell models. IDA and DOX SLNs were developed from warm microemulsion precursors comprising emulsifying wax as the oil phase, and polyoxyl 20-stearyl ether (Brij 78) and D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS) as the surfactants. Anionic ion-pairing agents, sodium taurodeoxycholate (STDC) and sodium tetradecyl sulfate (STS), were used to neutralize the charges of the cationic anthracyclines and enhance entrapment of the drugs in the SLN. The in-vitro cytotoxicity results showed that the IC50 value of DOX NPs was 9-fold lower than that of free DOX solution in resistant P388/ADR cell line. In contrast, free IDA had comparable IC50 values as IDA NPs in Pgp-overexpressing P388/ADR and HCT-15 cells. In the in-vivo P388/ADR leukemia mouse model, the median survival time of DOX NPs was significantly greater than that of free DOX, and controls. In contrast, free IDA was equally as effective as IDA NPs in P388 and Pgp-overexpressing HCT-15 mouse tumor models. The cell uptake of IDA formulated as free IDA and IDA NPs was comparable in Pgp-overexpressing cells. In conclusion, DOX NPs could overcome Pgp-mediated MDR both in-vitro in P388/ADR leukemia cells and in-vivo in the murine leukemia mouse model. The present study suggests that our SLNs may offer potential to deliver anticancer drugs for the treatment of Pgp-mediated MDR in leukemia; however, selection of target drug may be very important.
Full-text · Article · Apr 2009 · Journal of Biomedical Nanotechnology
Available from: Jin Dai
A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: extraction methods, stability, anticancer properties and mechanisms. Food Chem Toxicol
J. Dai
· A. Gupte ·
L. Gates
R.J. Mumper
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The purpose of these studies was to investigate and compare the composition, stability, antioxidant and anticancer properties and mechanisms of anthocyanin-containing blackberry extracts (ACEs) from selected cultivars and using different extraction methods. ACEs were analyzed for total anthocyanin and phenolics content, polymeric color, and total antioxidant capacity (TAC). The influence of water content in the extraction system was evaluated. A 90-day stability study of the extract and a 48-h stability study of the extract in biologically relevant buffers were completed. The cytotoxic effects of ACEs on HT-29, MCF-7, and HL-60 cells were determined. H2O2 production in culture medium was measured and intracellular ROS levels were quantified. As compared to powder-derived ACEs, puree-derived ACEs contained similar amounts of anthocyanins, but greater levels of phenolics, increased TAC, significantly enhanced production of H2O2, and significantly enhanced cytotoxicity in all cell lines. Catalase could not protect cells from ACE-induced cell death. Cyanidin 3-glucoside exerted anticancer effect by acting synergistically or additively with other active components in the extracts. These data suggest that anthocyanins and non-anthocyanin phenolics in ACEs act synergistically or additively in producing anticancer effects. These studies also provide essential information for the development of fruit-derived ACEs as potential Botanical Drug Products.
Full-text · Article · Feb 2009 · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association
Gupte A, Mumper RJElevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 35: 32-46
Anshul Gupte ·
Russell J Mumper
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As we gain a better understanding of the factors affecting cancer etiology, we can design improved treatment strategies. Over the past three to four decades, there have been numerous successful efforts in recognizing important cellular proteins essential in cancer growth and therefore these proteins have been targeted for cancer treatment. However, studies have shown that targeting one or two proteins in the complex cancer cascade may not be sufficient in controlling and/or inhibiting cancer growth. Therefore, there is a need to examine features which are potentially involved in multiple facets of cancer development. In this review we discuss the targeting of the elevated copper (both in serum and tumor) and oxidative stress levels in cancer with the aid of a copper chelator d-penicillamine (d-pen) for potential cancer treatment. Numerous studies in the literature have reported that both the serum and tumor copper levels are elevated in a variety of malignancies, including both solid tumor and blood cancer. Further, the elevated copper levels have been shown to be directly correlated to cancer progression. Enhanced levels of intrinsic oxidative stress has been shown in variety of tumors, possibly due to the combination of factors such as elevated active metabolism, mitochondrial mutation, cytokines, and inflammation. The cancer cells under sustained ROS stress tend to heavily utilize adaptation mechanisms and may exhaust cellular ROS-buffering capacity. Therefore, the elevated copper levels and increased oxidative stress in cancer cells provide for a prospect of selective cancer treatment.
No preview · Article · Oct 2008 · Cancer Treatment Reviews
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Enhanced Intracellular Delivery of the Reactive Oxygen Species (ROS)-Generating Copper Chelator D-Penicillamine via a Novel Gelatin−D-Penicillamine Conjugate
Anshul Gupte ·
Saurabh Wadhwa
Russell J Mumper
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D-Penicillamine (D-pen) is an established copper chelator. We have recently shown that the copper-catalyzed D-pen oxidation generates concentration-dependent hydrogen peroxide (H 2O 2). Additionally, D-pen coincubated with cupric sulfate resulted in cytotoxicity in human leukemia and breast cancer cells due to the extracellular generation of reactive oxygen species (ROS). The inherent physicochemical properties of D-pen such as its short in vivo half-life, low partition coefficient, and rapid metal catalyzed oxidation limit its intracellular uptake and the potential utility as an anticancer agent in vivo. Therefore, to enhance the intracellular delivery and to protect the thiol moiety of D-pen, we designed, synthesized, and evaluated a novel gelatin-D-pen conjugate. D-pen was covalently coupled to gelatin with a biologically reversible disulfide bond with the aid of a heterobifunctional cross-linker ( N-succinimidyl-3-(2-pyridyldithio)-propionate) (SPDP). Additionally, fluorescein-labeled gelatin-D-pen conjugate was synthesized for cell uptake studies. D-pen alone was shown not to enter leukemia cells. In contrast, the qualitative intracellular uptake of the conjugate in human leukemia cells (HL-60) was shown with confocal microscopy. The conjugate exhibited slow cell uptake (over the period of 48 to 72 h). A novel HPLC assay was developed to simultaneously quantify both D-pen and glutathione in a single run. The conjugate was shown to completely release D-pen in the presence of glutathione (1 mM) in approximately 3 h in PBS buffer, pH 7.4. The gelatin-D-pen conjugate resulted in significantly greater cytotoxicity compared to free D-pen, gelatin alone, and a physical mixture of gelatin and D-pen in human leukemia cells. Further studies are warranted to assess the potential of D-pen conjugate in the delivery of D-pen as a ROS generating anticancer agent.
No preview · Article · Aug 2008 · Bioconjugate Chemistry
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Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells
Anshul Gupte ·
Russell J Mumper
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Serum and tumor copper levels are significantly elevated in a variety of malignancies including breast, ovarian, gastric, lung, and leukemia. D-Penicillamine (D-pen), a copper-chelating agent, at low concentrations in the presence of copper generates concentration-dependent cytotoxic hydrogen peroxide (H(2)O(2)). The purpose of these studies was to investigate the in vitro cytotoxicity, intracellular reactive oxygen species (ROS) generation, and the reduction in intracellular thiol levels due to H(2)O(2) and other ROS generated from copper-catalyzed D-pen oxidation in human breast cancer cells (BT474, MCF-7) and human leukemia cells (HL-60, HL-60/VCR, HL-60/ADR). D-pen (< or = 400 microM) in the presence of cupric sulfate (10 microM) resulted in concentration-dependent cytotoxicity. Catalase was able to completely protect the cells, substantiating the involvement of H(2)O(2) in cancer cell cytotoxicity. A linear correlation between the D-pen concentration and the intracellular ROS generated was shown in both breast cancer and leukemia cells. D-pen in the presence of copper also resulted in a reduction in intracellular reduced thiol levels. The H(2)O(2)-mediated cytotoxicity was greater in leukemia cells compared to breast cancer cells. These results support the hypothesis that D-pen can be employed as a cytotoxic copper-chelating agent based on its ROS-generating ability.
No preview · Article · Nov 2007 · Free Radical Biology and Medicine
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An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation
Anshul Gupte ·
Russell J Mumper
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D-Penicillamine is a potent copper (Cu) chelating agent. D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. It has been proposed that hydrogen peroxide is generated during this process. However, definitive experimental proof that hydrogen peroxide is generated remains lacking. Thus, the major aims of these studies were to confirm and quantitatively assess the in vitro production of hydrogen peroxide during copper catalyzed D-penicillamine oxidation. The potential cytotoxic effect of hydrogen peroxide generation was also investigated in vitro against MCF-7 human breast cancer cells. Cell cytotoxicity resulting from the incubation of D-penicillamine with copper was compared to that of D-penicillamine, copper and hydrogen peroxide. The mechanism of copper catalyzed D-penicillamine oxidation and simultaneous hydrogen peroxide production was investigated as a function of time, concentration of cupric sulfate or ferric chloride, temperature, pH, anaerobic condition and chelators such as ethylenediaminetetraacetic acid and bathocuproinedisulfonic acid. A simple, sensitive and rapid HPLC assay was developed to simultaneously detect D-penicillamine, its major oxidation product D-penicillamine disulfide, and hydrogen peroxide in a single run. Hydrogen peroxide was shown to be generated in a concentration dependent manner as a result of D-penicillamine oxidation in the presence of cupric sulfate. Chelators such as ethylenediaminetetraacetic acid and bathocuproinedisulfonic acid were able to inhibit D-penicillamine oxidation. The incubation of MCF-7 human breast cancer cells with D-penicillamine plus cupric sulfate resulted in the production of reactive oxygen species within the cell and cytotoxicity that was comparable to free hydrogen peroxide.
No preview · Article · May 2007 · Journal of Inorganic Biochemistry
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Available from: Craig S Atwood
Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases
Zhengrong Cui
Paul R Lockman
Craig S Atwood
Cheng-Hsuan Hsu
· Anshul Gupte ·
David D Allen
Russell J Mumper
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Metal ions accumulate in the brain with aging and in several neurodegenerative diseases. Aside from the copper storage disease, Wilson's disease, recent attention has focused on the accumulation of zinc, copper and iron in the Alzheimer's disease (AD) brain and the accumulation of iron in Parkinson's disease. In particular, the parenchymal deposition of beta-amyloid (Abeta) and its interaction with metal ions has been postulated to play a role in the progression of AD. Thus, the strategy of lowering brain metal ions and targeting the interaction of Abeta peptide and metal ions through the administration of chelators has merit. Our recent finding that nanoparticle delivery systems can cross the blood-brain barrier has led us to investigate whether chelators delivered conjugated to nanoparticles could act to reverse metal ion induced protein precipitation. In the present studies, the Cu (I) chelator D-penicillamine was covalently conjugated to nanoparticles via a disulfide bond or a thioether bond. Nanoparticle-chelator conjugates were stable between pH 6-8 in aqueous suspension if stored at 4 degrees C, and did not aggregate when challenged with salts and serum. Release of D-penicillamine from the nanoparticles was achieved using reducing agents such as dithiothreitol (as a model for glutathione). Nanoparticles treated only under reducing conditions that released the conjugated D-penicillamine were able to effectively resolubilize copper-Abeta (1-42) aggregates. These results indicate that nanoparticles have potential to deliver D-penicillamine to the brain for the prevention of Abeta (1-42) accumulation, as well as to reduce metal ion accumulation in other CNS diseases.
Full-text · Article · Mar 2005 · European Journal of Pharmaceutics and Biopharmaceutics
Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases
Z Cui
Lockman P.R.
Craig Atwood
Hsu C.-H
· A Gupte ·
Allen D.D.
Mumper R.J.
No preview · Article · Jan 2005
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Available from: archive.uky.edu
Anshul Gupte
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The significantly increased copper and oxidative stress levels are characteristic hallmarks of cancer cells. These differences provide a unique opportunity for selective targeting of cancer cells. D-penicillamine (D-pen) has been proposed to generate reactive oxygen species (ROS) in presence of copper. Therefore, these studies were aimed at investigating the potential application of a currently marketed copper chelator, D-pen, as a novel cytotoxic anti-cancer agent. D-pen was shown to produce ROS, specifically hydrogen peroxide (H2O2), in the presence of cupric sulfate through a copper catalyzed oxidation reaction. During this process D-pen was converted to D-pen disulfide. The experimental proof of the H2O2 generation was conclusively shown with the aid of a novel High Performance Liquid Chromatography (HPLC) assay. The in-vitro cytotoxicity of D-pen co-incubated with cupric sulfate was examined in human beast cancer (MCF-7 and BT474) and leukemia cells (HL-60, HL-60/VCR, and HL-60/ADR). D-pen was shown to cause concentration dependent cytotoxicity in both leukemia and breast cancer cells. A direct correlation between the detection of intracellular ROS and cytotoxicity was established. The treatment of D-pen plus cupric sulfate resulted in a significant reduction in the intracellular thiol content. D-pen is highly hydrophilic and is rapidly eliminated from the body; therefore to improve the intracellular uptake and to protect the thiol group of D-pen, we carried out the synthesis and the in-vitro characterization of a novel gelatin-D-pen conjugate. It was shown that D-pen alone does not enter cells. Confocal microscopy was employed to exhibit the uptake of the novel gelatin-D-pen conjugate by cancer cells. As the cancer cells in-vitro do not accumulate the same levels of copper as reported for cancer cells in-vivo, cancer cells were pre-treated with cupric sulfate to simulate the elevated copper levels. The cupric sulfate pretreatment resulted in reduced thiol level and significantly increased cellular copper content compared to untreated cells. Whereas both free D-pen and gelatin-D-pen conjugate lacked cytotoxicity in un-treated cells, both agents caused concentration dependent cytotoxicity in cupric sulfate pre-treated leukemia cells. Therefore, it was shown that the administration of D-pen as polymer conjugate would potentially provide cytotoxicity and specificity in the treatment of cancer.
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Craig S Atwood
University of Wisconsin, Madison
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Jin Dai
University of Kentucky
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Paul R Lockman
Texas Tech University Health Sciences Center
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Ping Ma
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Russell J Mumper
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