text:
OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis (OPTIMIZE)
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Cystic Fibrosis
Drug: azithromycin
Drug: placebo
Drug: Tobramycin solution for inhalation
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis: The OPTIMIZE Multicenter, Placebo-Controlled, Double-Blind, Randomized Trial
- Time to a protocol-defined pulmonary exacerbation [ Time Frame: Over the 18-month study period ] [ Designated as safety issue: Yes ]
- Time to Pseudomonas aeruginosa (Pa) recurrence [ Time Frame: Over the 18-month study period ] [ Designated as safety issue: No ]
- Safety as measured by the incidence of adverse events and laboratory abnormalities [ Time Frame: Over the 18- month study period ] [ Designated as safety issue: Yes ]
|Estimated Enrollment:
|Study Start Date:
|June 2014
|Estimated Study Completion Date:
|April 2018
|Estimated Primary Completion Date:
|February 2018 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: azithromycin and TIS
azithromycin and tobramycin solution for inhalation (TIS) Azithromycin 3 times weekly, oral suspension, 10 mg/kg/dose up to 500 mg, for 18 months Tobramycin solution for inhalation (TIS), 300 mg, twice daily for 28 days when respiratory cultures are found positive for Pa at study visits for 18 months
Drug: azithromycin
3 times weekly, oral suspension, 10 mg/kg/dose up to 500 mg, for 18 monthsDrug: Tobramycin solution for inhalation
300 mg, twice daily for 28 days when respiratory cultures are found positive for Pa at study visits for 18 months
Other Name: TIS
Placebo Comparator: placebo and TIS
placebo and tobramycin solution for inhalation (TIS) Placebo 3 times weekly, oral suspension, volume-matched to azithromycin, for 18 months Tobramycin solution for inhalation (TIS), 300 mg, twice daily for 28 days when respiratory cultures are found positive for Pa at study visits for 18 months
Drug: placebo
3 times weekly, oral suspension, volume-matched to azithromycin, for 18 monthsDrug: Tobramycin solution for inhalation
300 mg, twice daily for 28 days when respiratory cultures are found positive for Pa at study visits for 18 months
Other Name: TIS
Detailed Description:
Cystic fibrosis (CF) lung disease begins in the first few months of life and follows a course of recurrent lower airway bacterial infection and inflammation and progression of disease over years and decades at a variable pace. With the development of chronic lung infection, obstructive disease progressively worsens, ultimately leading to respiratory failure. Pseudomonas aeruginosa (Pa) is the most important pathogen infecting the CF lower airways, and its acquisition early in life is associated with a pro-inflammatory effect, lower lung function, poor nutritional outcomes, and decreased survival.
Pseudomonas aeruginosa (Pa) infection of the cystic fibrosis (CF) airway typically proceeds from early infection to chronic infection. Although some studies have shown that a minority of individuals with CF spontaneously clear early Pseudomonas aeruginosa (Pa) infection, data from multiple studies suggest that antibiotics are superior to no treatment in clearing Pseudomonas aeruginosa (Pa) from respiratory cultures. Understanding the transition period from early to chronic Pseudomonas aeruginosa (Pa) infection is thus of critical importance in identifying strategies to prevent this progression.
The study will assess the clinical and microbiologic efficacy and safety of azithromycin given three times weekly in combination with standardized tobramycin solution for inhalation (TIS) therapy among children with early Pseudomonas aeruginosa (Pa). TIS therapy is defined as an initial eradication treatment with 1-2 courses of 28 days TIS and subsequent 28 day treatments only at times a quarterly respiratory culture is positive for Pseudomonas aeruginosa (Pa). Eligible participants will be randomized within one month of their Pseudomonas aeruginosa (Pa) positive culture to receive one of the following two treatment strategies for 18 months: (1) oral placebo in addition to standardized TIS therapy, or (2) oral azithromycin in addition to standardized TIS therapy.
At the first study visit, participants will undergo a physical examination and a review of their medical history. Lung function will be measured via spirometry (in children greater than four years of age who are able to perform spirometry), electrocardiogram (ECG) testing will be conducted, and hearing ability will be measured via audiometry. Blood will be drawn for laboratory tests and a specimen will be obtained for a respiratory culture before randomization and study drug dispensing occurs. Subsequent study visits will take place at Day 21, Weeks 13, 26, 39, 52, 65, and 78. At each visit, participants will undergo a physical examination, a spirometry test (as appropriate), a respiratory specimen for Pseudomonas aeruginosa (Pa) culture will be collected and study drug will be dispensed (except at Week 78). Participants will complete self-report or parent-completed respiratory symptom questionnaires and signs and symptoms evaluations will be performed at all visits. Repeat hearing and laboratory tests will be performed at Weeks 39 and 78 and ECG testing will be repeated at Day 21 and Week 78. Participants will be required to maintain a medication diary throughout the study.
|Ages Eligible for Study:
|6 Months to 18 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age ≥ 6 months to ≤ 18 years
- Documentation of a CF diagnosis as evidenced by one or more clinical features consistent with the CF phenotype or positive CF Newborn Screening result for immunoreactive trypsinogen (IRT) IRT/DNA or IRT/IRT and one or more of the following criteria:
- sweat chloride ≥ 60 milliequivalent (mEq)/liter by quantitative by pilocarpine iontophoresis test (QPIT)
- two well-characterized mutations in the cystic fibrosis transmembrane conductive regulator (CFTR) gene
- Abnormal nasal potential difference (NPD) (change in NPD in response to a low chloride solution and isoproteronol of less than - 5 mV)
- Documented new positive oropharyngeal, sputum or lower respiratory tract culture for Pa within 30 days of the Baseline Visit (Visit 1), defined as: a) first lifetime documented Pa positive culture; or b) Pa recovered after at least a two-year history of Pa negative respiratory cultures (≥ 1 culture/ year)
- Clinically stable with no evidence of any significant respiratory symptoms at the Baseline Visit that would require administration of intravenous anti- pseudomonal antibiotics, oxygen supplementation, and/or hospitalization as determined by the study physician
- Written informed consent obtained from participant or participant's legal representative (and assent when applicable) and ability for participant to comply with the requirements of the study
Exclusion Criteria:
- Macrolide antibiotic use within 30 days of the Baseline Visit
- Initiation of current course of treatment with TIS >14 days prior to Baseline Visit
- Weight <6.0 kg at the Baseline Visit
- History of aminoglycoside hypersensitivity or adverse reaction to inhaled aminoglycoside
- History of azithromycin hypersensitivity or adverse reaction to azithromycin or allergy to macrolide antibiotics
- History of positive respiratory culture for Non-tuberculous mycobacteria (NTM) or Burkholderia cepacia complex within 2 years of the Baseline Visit
- History of unresolved, abnormal renal function (defined as serum creatinine greater than 1.5 times the upper limit of normal for age).
- History of unresolved, abnormal liver function tests (defined as alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) greater than 4 times the upper limit of normal range) or history of portal hypertension
- History of unresolved, abnormal neutropenia (ANC ≤ 1000)
- Abnormal ECG test at the Baseline Visit defined as a QT interval corrected (QTc) (B) of ≥460 msec or history of ventricular arrhythmia
- History of abnormal hearing sensitivity defined as hearing threshold levels >25 dB HL (decibels Hearing Level) for visual reinforcement audiometry (VRA) at any frequency (500-4000Hz) or >20 Decibels Hearing Level (dBHL) for play or standard audiometry at any two frequencies (500-8000Hz) in either ear, not associated with middle ear disease (including infection) or a flat (Type B) tympanogram
- New initiation of chronic therapy (greater than 21 days) with drugs known to prolong QT interval including ciprofloxacin and trimethoprim-sulfa (refer to Appendix III) within 30 days prior to the Baseline Visit or coadministration of nelfinavir or oral anticoagulants
- Positive serum or urine pregnancy test at the Baseline Visit (to be performed on all females of child-bearing potential) or for females of child bearing potential: pregnant, breastfeeding, or unwilling to use barrier contraception during participation in the study
- Administration of any investigational drug within 30 days prior to the Baseline Visit
- Presence of a condition or abnormality (e.g., pre-existing heart disease) that in the opinion of the site investigator would compromise the safety of the participant or the quality of the data
Please refer to this study by its ClinicalTrials.gov identifier: NCT02054156
|Contact: Jean Kirihara
|Contact: Irene Bondick
Hide Study Locations
|United States, Alaska
|CFF Affiliate Program Providence Medical Center
|Anchorage, Alaska, United States, 99519-6604
|Contact: Katherine Nelson firstname.lastname@example.com
|United States, Arizona
|CFF Care Center Arizona Health Science Center
|Tucson, Arizona, United States, 85724
|Contact: Osmara Molina de Rodriguez email@example.com
|United States, Arkansas
|CFF Care Center & Pediatric Program Arkansas Children's Hospital
|Little Rock, Arkansas, United States, 72202
|Contact: Lacey LeAnn Ramsey email@example.com
|United States, California
|Childrens Hospital Los Angeles
|Not yet recruiting
|Los Angeles, California, United States, 90021
|Contact: Natalie Vajda email@example.com
|CFF Care Center & Pediatric Program Stanford University
|Palo Alto, California, United States, 94305
|Contact: Colleen Dunn email@example.com
|United States, Colorado
|CFF Care Center & Pediatric Program Children's Hospital Colorado
|Aurora, Colorado, United States, 80045
|Contact: Churee Pardee firstname.lastname@example.com
|United States, Connecticut
|CFF Care Center & Pediatric Program Yale University
|New Haven, Connecticut, United States, 06511
|Contact: Catalina Guzman firstname.lastname@example.com
|United States, Florida
|CFF Care Center & Pediatric Program Nemours Children's Clinic - Jacksonville
|Jacksonville, Florida, United States, 32207
|Contact: Elizabeth DeLuca firstname.lastname@example.com
|CFF Care Center & Pediatric Program All Children's Hospital
|St. Petersburg, Florida, United States, 33701
|Contact: Kathy Hosler firstname.lastname@example.com
|United States, Georgia
|CFF Care Center & Pediatric Program Emory University
|Atlanta, Georgia, United States, 30324
|Contact: Eric A Hunter email@example.com
|CFF Affiliate Program Children's Healthcare of Atlanta
|Atlanta, Georgia, United States, 30342
|Contact: Petra Raville firstname.lastname@example.com
|United States, Idaho
|CFF Care Center St. Luke's CF Clinic
|Boise, Idaho, United States, 83712
|Contact: Dixie Durham firstname.lastname@example.com
|United States, Illinois
|CFF Care Center & Pediatric Program Ann & Robert H. Lurie Children's Hospital of Chicago
|Chicago, Illinois, United States, 60611-2605
|Contact: Noopur Singh firstname.lastname@example.com
|United States, Indiana
|CFF Care Center & Pediatric Program Riley Hospital for Children
|Indianapolis, Indiana, United States, 46202-5271
|Contact: Lisa Bendy email@example.com
|United States, Iowa
|CFF Care Center & Pediatric Program University of Iowa
|Iowa City, Iowa, United States, 52242
|Contact: Mary Teresi email@example.com
|United States, Maine
|CFF Care Center & Pediatric Program Maine Medical Center
|Portland, Maine, United States, 04102
|Contact: Debra Burris email@example.com
|United States, Massachusetts
|CFF Care Center & Pediatric Program Children's Hospital Boston
|Boston, Massachusetts, United States, 02115
|Contact: Robert Fowler firstname.lastname@example.com
|United States, Michigan
|CFF Care Center & Pediatric Program University of Michigan
|Ann Arbor, Michigan, United States, 48109-5008
|Contact: Dawn Kruse email@example.com
|CFF Care Center & Pediatric Program Children's Hospital of Michigan
|Detroit, Michigan, United States, 48201
|Contact: Catherine Van Wagnen email@example.com
|United States, Missouri
|CFF Care Center The Children's Mercy Hospital
|Kansas City, Missouri, United States, 64108
|Contact: Candy Schmoll firstname.lastname@example.com
|CFF Care Center & Pediatric Program Cardinal Glennon Children's Hospital/Saint Louis University
|St. Louis, Missouri, United States, 63104
|Contact: Amy Cooper email@example.com
|CFF Care Center & Pediatric Program St. Louis Children's Hospital
|St. Louis, Missouri, United States, 63110
|Contact: Patricia A Burks firstname.lastname@example.com
|United States, Nebraska
|CFF Care Center & Pediatric Program University of Nebraska Medical Center
|Omaha, Nebraska, United States, 68105
|Contact: Raquel Telfer firstname.lastname@example.com
|United States, New Jersey
|CFF Care Center & Pediatric Program Monmouth Medical Center
|Long Branch, New Jersey, United States, 07740
|Contact: Bridget Marra firstname.lastname@example.com
|United States, New York
|CFF Care Center & Pediatric Program Columbia University
|New York, New York, United States, 10032
|Contact: Hossein Sadeghi email@example.com
|CFF Care Center & Pediatric Program SUNY Upstate Medical University
|Syracuse, New York, United States, 13210
|Contact: Donna Lindner firstname.lastname@example.com
|CFF Care Center New York Medical College
|Valhalla, New York, United States, 10595
|Contact: Ingrid Gherson firstname.lastname@example.com
|United States, North Carolina
|CFF Care Center & Pediatric Program University of North Carolina at Chapel Hill
|Chapel Hill, North Carolina, United States, 27514
|Contact: Carol Barlow firstname.lastname@example.com
|United States, Ohio
|CFF Care Center & Pediatric Program Akron Children's Hospital
|Akron, Ohio, United States, 44308
|Contact: Deborah Ouellette firstname.lastname@example.com
|CFF Care Center & Pediatric Program Cincinnati Children's Hospital Medical Center
|Cincinnati, Ohio, United States, 45229
|Contact: Beth Decker email@example.com
|CFF Care Center & Pediatric Program Rainbow Babies and Children's Hospital
|Cleveland, Ohio, United States, 44106
|Contact: Roberta Ksenich email@example.com
|CFF Care Center & Pediatric Program Nationwide Children's Hospital
|Columbus, Ohio, United States, 43205
|Contact: Diana Gilmore email@example.com
|CFF Care Center & Pediatric Program The Children's Medical Center
|Dayton, Ohio, United States, 45404
|Contact: Sandy Bartosik firstname.lastname@example.com
|United States, Oregon
|CFF Care Center & Pediatric Program Oregon Health & Sciences University
|Portland, Oregon, United States, 97201
|Contact: Kim Simmons email@example.com
|United States, Pennsylvania
|CFF Care Center & Pediatric Program Hershey Medical Center
|Hershey, Pennsylvania, United States, 17033
|Contact: Diane Kitch firstname.lastname@example.com
|CFF Care Center & Pediatric Program Children's Hospital of Pittsburgh
|Pittsburgh, Pennsylvania, United States, 15224
|Contact: Elizabeth Hartigan email@example.com
|United States, South Dakota
|CFF Care Center & Pediatric Program Sanford USD Medical Center
|Sioux Falls, South Dakota, United States, 57117
|Contact: Carmen Sandman firstname.lastname@example.com
|United States, Tennessee
|CFF Care Center & Pediatric Program University of Tennessee
|Memphis, Tennessee, United States, 38103
|Contact: Barbara Culbreath email@example.com
|United States, Texas
|CFF Care Center & Pediatric Program Dell Children's Medical Center of Central Texas
|Austin, Texas, United States, 78723
|Contact: Isolde Brazil email@example.com
|United States, Utah
|University of Utah
|Not yet recruiting
|Salt Lake City, Utah, United States, 84132
|Contact: Jane Vroom email@example.com
|United States, Virginia
|CFF Care Center & Pediatric Program Children's Hospital of the King's Daughters
|Norfolk, Virginia, United States, 23507
|Contact: Christine R Buescher firstname.lastname@example.com
|CFF Care Center Medical College of Virginia
|Richmond, Virginia, United States, 23298
|Contact: Matthew Ward email@example.com
|United States, Washington
|CFF Care Center & Pediatric Program Seattle Children's Hospital
|Seattle, Washington, United States, 98105
|Contact: Sharon McNamara email@example.com
|United States, Wisconsin
|CFF Care Center & Pediatric Program University of Wisconsin
|Madison, Wisconsin, United States, 53792
|Contact: Linda Makholm email@example.com
|CFF Care Center & Pediatric Program Children's Hospital of Wisconsin
|Milwaukee, Wisconsin, United States, 53226
|Contact: Theresa Kump firstname.lastname@example.com
|Principal Investigator:
|Bonnie Ramsey, MD
|Seattle Children's Center for Clinical and Translational Research, CF Therapeutics Development Network Clinical Coordinating Center
|Principal Investigator:
|Nicole Hamblett, PhD
|Seattle Children's Core for Biomedical Statistics
|Responsible Party:
|Bonnie Ramsey, Professor of Pediatrics, Seattle Children's Hospital
|ClinicalTrials.gov Identifier:
|NCT02054156 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 1, 2014
|Last Updated:
|September 25, 2015
|Health Authority:
|United States: Food and Drug Administration
United States: Institutional Review Board
Keywords provided by Seattle Children's Hospital:
Cystic fibrosis (CF)
Tobramycin solution for inhalation (TIS)
Pseudomonas aeruginosa (Pa)
Early Pseudomonas aeruginosa infection
Pulmonary exacerbation
Standardized anti-pseudomonal therapy
Additional relevant MeSH terms:
Cystic Fibrosis
Pseudomonas Infections
Bacterial Infections
Digestive System Diseases
Genetic Diseases, Inborn
Gram-Negative Bacterial Infections
Infant, Newborn, Diseases
Lung Diseases
Pancreatic Diseases
Pathologic Processes
Respiratory Tract Diseases
Pharmaceutical Solutions
Anti-Bacterial Agents
Anti-Infective Agents
Pharmacologic Actions
Therapeutic Uses
ClinicalTrials.gov processed this record on April 27, 2016


text:
My 3 year old son is obsessed with his pee pee. ĀI realize this is normal to a point, however I think he has let the dog lick his penis on more than one occassion? ĀThe first time I found my son & and the dog in his bed room. ĀThe door was shut and my son was zipping up his pants while standing right in front of the dog. ĀThe second time I had walked into the other room to get a clean pair of underwear for my son & I came back & my son was standing naked right in front of the dogs face. Ā I said what are you doing? ĀHeĀsmirked this guilty smile & said nothing. ĀThen he said "dont tell daddy"? Ā
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subset: commoncrawl


text:
Her cowgirls! Lisa Marie Presley arrives in Japan with her twin daughters Harper and Finley wearing cowboy boots
She might not have been home in Memphis, Tennessee, but Lisa Marie Presley still had a reminder of her ranch roots thanks to her twin daughters.
Five-year-olds Harper and Finlay held their mother's hands as they walked thorough the Narita International Airport in Japan, wearing pretty cowboy boots on their feet.
Their 46-year-old mother, however, opted for a more puritanical style, in a black and white collared top.
Memphis memories: Lisa Marie Presley holds her twin daughters' hands as they walk in cowboy boots through Narita International Airport
However, the outfit was given a touch of sauciness thanks to Lisa Marie's leather skirt and fishnet tights, as well as a flash of red lipstick on the singer's lips.
Presley is currently on tour, having arrived in Japan from Australian after playing a string of dates from Sydney to Melbourne.
Lisa Marie has also been raving about her weight loss, which was inspired by the fact that her famous father Elvis Presley passed away at the age of 42, because he was grossly overweight and dependent on prescription drugs.
Little girls: Harper and Finley both have their hair in top knots too as they walk through the airport
Tour: Lisa Marie is currently on tour and arrived into Japan from Australia
Sexy puritan: The black top and white collared shirt might have been prim, but Presley's leather skirt and fishnet tights certainly weren't
Slimmer than ever: Lisa Marie Presley has lost a great deal of weight after vowing to live a healthier lifestyle because of fears she could die young like her dad
His only daughter has admitted her
worries about dying young like her dad prompted her to lose weight, with
the result that at 46 she is now in the best shape of her life,
weighing the same as she did when she was a teenager.
She told People: 'Knowing my family history – my father's side is totally not healthy and they have shorter life spans, while my mom's side is super fit with long life spans – I didn't know where I would land. So I said, "Okay. I'm going to play it safe and try to be as healthy as I can be.
'I'm at the weight I was at when I was a teenager. I love the way clothes fit right now.'
Now and then: Lisa Marie has revealed she now weights the same as she did when she was a teenager [right in 1986] and is at her 'happy weight'
Tragic: Lisa Marie's father Elvis Presley died bloated and addicted to prescription drugs n 1977
The mother-of-four, she has daughter
Riley, 24, and son Benjamin, 21, from her first marriage to Danny Keough
and five-year-old twins Harper and Finley with husband Michael
Lockwood, tries to eat organic where possible and has cut down her
portion sizes.
She said: 'Eating clean and organic is best. I eat half of what I am given, especially when I have carbs or grains.'
Marie - whose mother is Priscilla Presley, 68 - first made the
conscious decision to start looking after herself when she went on tour
in 2012 but says running after her twins does keep her fit too.
Changing shape: Lisa Marie has battled with her weight fluctuating wildly [left in 1997 and right in 2003]
She explained: Being on the road for a three-month run gets intense. I can be really, super disciplined, but I can also be really not disciplined.
'I can't always get off the bus and walk for 30 minutes. But the show is 90 minutes long and I'm constantly moving and my adrenaline is pumping, so I'm sure that is burning calories.'
The singer - who is currently on tour in Australia - added: 'The twins are with me on tour and are constantly on the go, so they keep me moving.
'I do chase after them, but it's not just that. There's always so much going on with the little ones and the older ones, too.'
Slim: Lisa Marie is now at the same weight as a teenager and similar to 1991 [pictured with first husband Danny Keough]
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text:
Located in
Kahurangi National Park and Mount Arthur area in
the Nelson/Tasman region
Bookings not required - first come, first served
4WD is recommended on the narrow and steep access road into the Mount Arthur area (Graham Valley Road):
Upper Gridiron Hut
NZTopo50 map sheet: BQ23
Grid/NZTM2000 coordinates: E1574524, N5442195
Before you go, buy 1 Standard Hut Ticket (blue for adults, yellow for youth) for each night's stay. Put this in the honesty box at the hut. Or buy a Backcountry Hut Pass that gives unlimited use at most Standard and Serviced huts for a 6 or 12 month period.
Read more about hut tickets and passes | Find retailers that sell hut tickets
The wood burner at the Upper Gridiron Hut has been removed due to its poor state and dangerous condition. There is currently no heating provided inside the hut.


text:
Antacids help to treat heartburn (indigestion). They work by changing the stomach acid that causes heartburn.
You can buy many antacids without a prescription. Liquid forms work faster, but you may like tablets because they are easy to use.
All antacids work equally well, but they can cause different side effects. If you use antacids often and have problems with side effects, talk with your health care provider.
Heartburn - self-care
Antacids are a good treatment for heartburn that occurs once in awhile. Take antacids about 1 hour after eating or when you have heartburn. If you are taking them for symptoms at night, DO NOT take them with food.
Antacids cannot treat more serious problems, such as appendicitis, a stomach ulcer, gallstones, or bowel problems. Talk to your provider if you have:
Call your provider if you need to use antacids on most days.
You may have side effects from taking these medicines. Antacids are made with 3 basic ingredients. If you have problems, try another brand.
Antacids can change the way your body absorbs the other medicines you are taking. It is best to take any other medicine either 1 hour before or 4 hours after you take antacids.
Talk to your provider or pharmacist before taking antacids on a regular basis if:
Ferrandino MN, Pietrow PK, Preminger GM. Evaluation and medical management of urinary lithiasis. In: Wein AJ, ed. Campbell-Walsh Urology. 10th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 46.
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308-328.


text:
Bobbing for Another Apple
(GOOG) Android and iPhones.Follow @RobertWeinstein This article is commentary by an independent contributor, separate from TheStreet's regular news coverage.Only the very bottom estimates for 2014 (the next fiscal year) suggest 2014 will not turn into a record year for revenue. Yet, as clear as crystal, emotion has taken hold of the weaker hands, and the stock is trading with single-digit P/Es. Intel didn't delight Wall Street with its last earnings report and continues to trade at a higher valuation. Don't get me wrong, I am bullish on Intel, but it's a good example to use since the chipmaker reported a few days ago. RIM and Nokia may move around as the headlines pump and dump the stocks, but in the end, both have massive headwind in trying to gain a real foothold of market share currently occupied by Google's
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Rovo/Steve Hillage/System 7: Phoenix Rising
1 CD / Cleopatra / 2016-03-18Artists: Rovo/Steve Hillage/System 7
Hatsune Miku: Hatsune Miku Expo 2016 EP [EP] *
1 CD / / 2016-03-18Artists: Hatsune Miku
Projects such as Still Be Here, a collaboration with experimental electronic artist Laurel Halo, proved that the concept of Hatsune Miku could be taken in the most avant-garde directions. However, the...continue...
Max Graham: Cycles, Vol. 7
1 CD / Black Hole Recordings (Netherlands) / 2016-03-18Tracks: Equinox; Errors; To Declare; Lotos [Vocal Mix] - (remix, featuring Avenax); Out of Staight; Into You; Terminal; Chaotically; Up to the Groove [Dub Mix] - (remix); Wall; One Hundred [Raw Mix] - (remix...
Artists: Max Graham
Audio Mixer: Max Graham.
Liner Note Author: Jay Fenster....continue...
Public Memory: Wuthering Drum [Digipak]
1 CD / Felte / 2016-03-18Tracks: Heir; Mirror; Ringleader; Domino; Cul de Sac; As You Wish; Interfaith; Zig Zag; Earwig; Lunar
Artists: Public Memory
With his previous project ERAAS, Robert Toher's music often seemed caught between the post-rock of his first band, Apse, and something -- or somewhere -- harder to define and more interesting. Toher r...continue...
Piano Interrupted: Landscape of the Unfinished [Digipak]
1 CD / Denovali / 2016-03-18Tracks: Waraba; Abdou Kadre; Vieux; Mamadou Fall; Oumar Konte; Sara Ba; Vieux (Reprise); Jean Luc Diola; Pape Malick Diome
Artists: Piano Interrupted
Personnel: Oumar Konte, Abdou Kadre, Antoine Phillipe (kora); Sara Ba (flute); Tom Hodge (clarinet, piano); Tim Fairhall (double bass); Pape Malick Diome (talking drum); Franz Kirmann (electronics)....continue...
Eek (Egypt): Kahraba [Digipak]
1 CD / Nashazphone / 2016-03-18Tracks: Trinity; Kahraba; Bawaba, El; Mouled El-Ghoul
Artists: Eek (Egypt)
Betty Boo: Grrr! It's Betty Boo [Deluxe Edition]
2 CD / Cherry Pop / 2016-03-18Tracks: I'm on My Way; Thing Goin' On; Hangover; Curly & Girly; Wish You Were Here; Let Me Take You There; Gave You the Boo; Skin Tight; Catch Me; Close the Door; Jet Sex [7 " Version]; Platform Shoe Shuffle...
Artists: Betty Boo
Personnel: Betty Boo (vocals); Michael Rosenberg (guitar); Roger Rettig (pedal steel guitar); Fenella Barton, Sian Bell, Sonia Shany, Jocelyn Pook (strings); Ronnie Scott, Harry Klein, Bill Povey, Gar...continue...
Lust for Youth: Compassion *
1 CD / Sacred Bones / 2016-03-18Tracks: Stardom; Limerence; Easy Window; Sudden Ambitions; Better Looking Brother; Display; Tokyo; In Return
Artists: Lust for Youth
It's not an overstatement to say that International was a huge step forward for Lust for Youth: As Hannes Norrvide's solo project became a trio, his introspection moved from underneath headphones onto...continue...
Toshiya Kawasaki: I'm Starting To Feel Okay, Vol. 7
2 CD / Mule Musiq / 2016-03-18Tracks: Make It Move; Rainbow Disco; Mother Nature; Flying Blue; Don't Need to Know; Ruff Rollin; Still Clock; Minifloat; Mysore; Newwave Project, No 11; Leguan; Midday Theme - (featuring Miss Midday); Amede...
Artists: Toshiya Kawasaki
Baauer (Harry Bauer Rodrigues): Aa [Slipcase] *
1 CD / Luckyme / 2016-03-18Tracks: Church; Gogo!; Body; Pinku; Sow; Day Ones; Good & Bad; Way From Me; Temple; Make It Bang; Kung Fu; Church (Reprise); Aa
Artists: Baauer (Harry Bauer Rodrigues)
Composer: Baauer .
Personnel: G-Dragon, Future , Tirzah, TT The Artist, Novelist , Leikeli47, Pusha T, M.I.A. (vocals); Rustie (guitar).
Audio Mixer: Ryan Schwabe.
Philadelphia pr...continue...
Thomas Köner: Tiento de la Luz [Slipcase] *
1 CD / Denovali / 2016-03-18Tracks: Tiento de la Luz 1; Tiento de la Luz 2; Tiento de la Luz 3; Tiento de la Luz 4; Tiento de la Luz 5; Tiento de la Luz 6
Artists: Thomas Köner
Personnel: Thomas Köner (percussion, electronics); Srdjan Stanic (viola); Ivana Neimarevic (piano).
German ambient pioneer Thomas Köner has often used acoustic instruments as source m...continue...
Aurora (Norway): All My Demons Greeting Me as a Friend
1 CD / Decca / 2016-03-18Artists: Aurora (Norway)
Steeped in gelid electronic textures, pulsing beats, and yearning modalities, Aurora's All My Demons Greeting Me as a Friend also blends vivid lyrical imagery with parts fantasy and heartache for a ha...continue...
Redfoo: Party Rock Mansion [PA] [Slipcase] *
1 CD / Party Rock / 2016-03-18Tracks: Keep Shining; Party Train; Too Much; Beach Cruisin'; Booty Man; Lights Out; So Lit; New Thang; Juicy Wiggle; Good Things Happen When Ya Drunk; Where the Sun Goes; Meet Her at Tomorrow - (featuring Di...
Artists: Redfoo
Audio Mixers: Redfoo; Brandon Garcia.
Recording information: Party Rock Mansion, Hollywood, CA.
Editor: Dave Boyles.
There are so many ways to look at Redfoo. He's the youngest so...continue...
Redfoo: Party Rock Mansion [Clean] [Digipak] *
1 CD / Party Rock / 2016-03-18Tracks: Keep Shining; Party Train; Too Much; Beach Cruisin'; Booty Man; Lights Out; So Lit; New Thang; Juicy Wiggle; Good Things Happen When Ya Drunk; Where the Sun Goes; Meet Her at Tomorrow - (featuring Di...
Artists: Redfoo
Audio Mixer: Redfoo.
Recording information: Party Rock Manison, Hollywood, CA.
Editor: Dave Boyles.
There are so many ways to look at Redfoo. He's the youngest son of Motown found...continue...
Solar Bears (Irish Duo): Advancement [Digipak]
1 CD / Sunday Best (UK) / 2016-03-18Tracks: Everything Set Right; Man Plus; Age: Atomic; Vanishing Downstream; Scale; Persona; Wild Flowers; Gravity Calling; Everything Set Ablaze; Longer Life; Separate from the Arc
Artists: Solar Bears (Irish Duo)
Audio Mixer: Ivan Jackman.
Creator: Solar Bears .
Following two well-received albums and an EP for Mike Paradinas' Planet Mu, Irish electronic duo Solar Bears moved to Rob Da Bank's Sund...continue...
MMOTHS: Luneworks [Digipak] *
1 CD / Because Music / 2016-03-18Tracks: You; Deu; Phase In; Para Polaris; Verbena; Scent; Eva; Lucid; Body Studies; 1709; Phase Out; Ohm; Naoko, Pt. 1; Naoko, Pt. 2
Artists: MMOTHS
Audio Mixer: Rian Trench.
Following two EPs released in 2012 and 2013, Irish electronic musician MMOTHS (Jack Colleran) took three years to write, record, and release his debut full-length, rel...continue...
Underworld: Barbara Barbara, We Face a Shining Future [Slipcase] *
1 CD / Astralwerks / 2016-03-18Tracks: I Exhale; If Rah; Low Burn; Santiago Cuatro; Motorhome; Ova Nova; Nylon Strung
Artists: Underworld
Recording information: Essex & Chile.
In the six years since the release of their merely good effort Barking, electronica veterans Underworld were tied up with big things, like solo projects, E...continue...
Manuel Volpe & Rhabdomantic Orchestra: Albore
1 CD / Agogo / 2016-03-18Artists: Manuel Volpe & Rhabdomantic Orchestra
Various Artists: Just Music Café, Vol. 5: Ambient Zone, Pt. 2 [Digipak]
1 CD / Just Music / 2016-03-18Tracks: Sentinel - Digitonal; On Wings - Afterhere; New Age Sunrise - Chris Coco; Autumn Hill - Jon Hopkins; Seeing or Agreeing - Sam Thomas; My Kingdom, Your Sunset - Loner; Caeleste - Echaskech; Last Sunri...
Artists: Various Artists
Audio Mixer: Chris Coco....continue...
Dave Kane: The Eye of the Duck
1 CD / Edition / 2016-03-18Tracks: Biff; Gorman, The; Hum; Sad Song; Eye of the Duck, The; Shut Up Sit Down; Only Way, The; Slip; Loulou's Theme
Artists: Dave Kane
Personnel: Dave Kane (bass instrument); Simon Kaylor (saxophone, tenor saxophone); Simon Beddoe (trumpet); Matthew Bourne , Matthew Nourne (Fender Rhodes piano); Joost Hendricks (drums); Joost Hendric...continue...
Cardiknox: Portrait
1 CD / Warner Bros. / 2016-03-11Tracks: Earthquake; Souvenirs; Wild Child; Doors; On My Way; Into the Night; Bloodlust; Supermodel; What Do I Do Now; Your Love; Perfect Storm; Shadowboxing
Artists: Cardiknox
Audio Mixer: Paul Lamalfa.
Recording information: Henson Recording Studios.
Photographer: Hazel & Pine.
The debut full-length album from New York's Cardiknox, 2016's Portrait, is ...continue...
Aurora (Norway): All My Demons Greeting Me as a Friend [Deluxe Edition]
1 CD / Glassnote Entertainment Group / 2016-03-11Artists: Aurora (Norway)
Steeped in gelid electronic textures, pulsing beats, and yearning modalities, Aurora's All My Demons Greeting Me as a Friend also blends vivid lyrical imagery with parts fantasy and heartache for a ha...continue...
Aurora (Norway): All My Demons Greeting Me as a Friend
1 CD / Glassnote Entertainment Group / 2016-03-11Tracks: Runaway; Conqueror; Running with the Wolves; Lucky; Winter Bird; I Went Too Far; Through the Eyes of a Child; Warrior; Murder Song; Home; Under the Water; Black Water Lilies
Artists: Aurora (Norway)
Personnel: Aurora (vocals); Magnus Skylstad (drums, percussion).
Recording information: Lydriket Studio, Bergen, Norway.
Photographer: Bent Rene Synnevag.
Steeped in gelid electro...continue...
Mothxr: Centerfold
1 CD / RED Music Solutions / 2016-03-11Tracks: Impossible; Stranger; Centerfold; Underground; Touch; Fight the Feeling; Easy; Victim; She Can't Tell; Wild Ride; I Can See You'll Never Make It Out
Artists: Mothxr
Whether they like it or not, Brooklyn's Mothxr are most likely going to be known as the band fronted by former Gossip Girl actor Penn Badgley. But that's not to say there isn't a lot to like about the...continue...
DJ Ultralight: Old School Jams DJ Mix
1 CD / Thump Records / 2016-03-11Tracks: Party Has Just Begun, The; Don't Stop the Rock; It's Automatic; Baby Love-Daphee; West Coast Poplock-Ronnie Hudson - (featuring Ronnie Hudson); Rain Forest; Clear; Electric Kingdom; It's Time
Artists: DJ Ultralight
La Yegros: Magnetismo [Slipcase] *
1 CD / Soundway / 2016-03-11Tracks: Magnetismo; Carnabailito; Atormentada; Chicha Roja; Hoy; Sueñitos; Arde; Déjate Llevar; Frágil; Lejos
Artists: La Yegros
Personnel: Mariana Yegros (vocals).
Audio Mixer: Anibal Kerpel .
Liner Note Author: Mariana Yegros.
Recording information: Estudios Mamboretá, Formosa, Argentina; Merlin Stud...continue...
Larry Levan: Genius of Time
2 CD / UMC / 2016-03-11Tracks: Life Is Something Special (Special Edition); Can't Shake Your Love [Larry Levan Mix] - (remix); Padlock [Larry Levan Mix] - (remix); Love Honey, Love Heartache [A Larry Levan Mix] - (remix); Carried ...
Artists: Larry Levan
Liner Note Author: Chris Menist....continue...
Guy Andrews: Our Spaces [Slipcase]
1 CD / Houndstooth / 2016-03-11Tracks: Higher Waters; All Our Flaws; Bereft of Focus, Bereft of Will; Spirit Ritual; Without Names; In Autumn Arms; Our Spaces; Nokken's Song; Perception; Decipher; Paganism; Terminus
Artists: Guy Andrews
Following five years with a number of EPs created for Hemlock Recordings, London-based producer and instrumentalist Guy Andrews gives us his debut full-length, Our Spaces, marking his first release fo...continue...
Matthew Bourne (Keyboards): Moogmemory [Slipcase] *
1 CD / The Leaf Label / 2016-03-11Tracks: Somewhere I Have Never Travelled (For Coral Evans); Alex; Nils; On Rivock Edge; Sam; Andrew; Horn and Vellum; Daniziel; I Loved Her, Madly
Artists: Matthew Bourne (Keyboards)
Audio Mixer: Sam Hobbs .
Quickly following the release of Radioland: Radio-Activity Revisited, a 40th anniversary reimagining of Kraftwerk's 1975 classic Radio-Aktivität in collaboration w...continue...
Zardonic: Antihero
1 CD / Eone Entertainment / 2016-03-11Artists: Zardonic
Breakbot: Still Waters
1 CD / Warner Bros. / 2016-03-04Tracks: Back for More; Arrested; Sweetest Romance, The; 2Good4Me; My Toy; Get Lost; Turning Around; Man Without Shadow; All It Takes; Wet Dream; Too Soon; In Return; Still Waters
Artists: Breakbot
French touch is all about synthesis, uniting house, disco, electro, R&B, and pop into a sound that's eternally nostalgic and contemporary, and in some ways, Breakbot's music is its logical end. This m...continue...
Various Artists: Miami Meets Ibiza 2016
1 CD / Relativity Entertainment / 2016-03-04Artists: Various Artists
Various Artists: Ultra Music Festival 2016
1 CD / Ultra / 2016-03-04Tracks: Stay - Kygo - (featuring Maty Noyes); November Skies - Carnage - (featuring Nina Kinert/Tomas Barford); Haters - Deorro/Will Sparks - (featuring iE-Z); It's Strange - Louis the Child - (featuring Kri...
Artists: Various Artists
Not Waving: Animals [Slipcase]
1 CD / Diagonal / 2016-03-04Tracks: Believe; Head Body; 24; Tomorrow We Will Kill You; I Know I Know I Know; Punch; Gutsy; Face Attack; Presenza Immobile; Work Talk; They Cannot Be Replaced; 28; 02
Artists: Not Waving
Junkie XL/Tom Holkenborg: Deadpool [Original Soundtrack]
1 CD / Milan / 2016-03-04Artists: Junkie XL/Tom Holkenborg
The Merc with a Mouth makes his big-screen debut in Deadpool. The film was soundtracked by electronic producer Junkie XL, who also worked on the music for Mad Max: Fury Road, Blade, The Amazing Spider...continue...
Låpsley: Long Way Home *
1 CD / XL / 2016-03-04Tracks: Heartless; Hurt Me; Falling Short; Cliff; Operator (He Doesn't Call Me); Painter; Tell Me the Truth; Station; Love Is Blind; Silverlake; Leap; Seven Months
Artists: Låpsley
Audio Mixer: Ben Baptie.
Photographer: Luke & Nik .
On her full-length debut Long Way Home, Holly Lapsley Fletcher, who performs as Låpsley, positions herself in the James Blake sec...continue...
Katy B: Honey
1 CD / Virgin EMI (Universal UK) / 2016-03-04Artists: Katy B
The Knocks: 55 *
1 CD / WEA (Distributor) / 2016-03-04Tracks: New York City - (featuring Cam'ron); Time; Classic - (featuring Powers); Kiss the Sky - (featuring Wyclef Jean); Dancing with Myself; Comfortable - (featuring X Ambassadors); I Wish (My Taylor Swift)...
Artists: The Knocks
At the start of their careers, New York electronic production duo the Knocks built their brand around remixes for high-profile artists like Ellie Goulding, Katy Perry, and Taylor Swift. They went on t...continue...
Kim & Buran: Orbita
1 CD / Nang / 2016-03-04Artists: Kim & Buran
Tiga: No Fantasy Required [Slipcase]
1 CD / Counter Records / 2016-03-04Tracks: No Fantasy Required; Make Me Fall in Love; 3 Rules; Having So Much Fun; Tell Me Your Secret; Always; Planet E; Plush; Bugatti; Don't Break My Heart; Blondes Have More Fun
Artists: Tiga
Recording information: Lost Star Studios MTL; Magic Hour Studios, NY; Turbo Recordings HQ Studio, MTL.
Released while the artist was declaring that when it comes to albums, "they don't even mat...continue...
Various Artists: Clubbers Guide 2016
2 CD / Ministry of Sound / 2016-03-04Artists: Various Artists
Thatmanmonkz: Columbusing
1 CD / Delusions of Grandeur / 2016-03-04Tracks: Air; Jus Anutha Wunna Deez; Boogie Down; Sum Ol' Nex' Ish; Fly New Tune, A; Turn It Out; Another Night Under The Glitterball; I Can Hardly Breathe; For Bae; Moon On The Hill; Vampires; Baked; Take U ...
Artists: Thatmanmonkz
Joey Negro: Remixed With Love By Joey Negro, Vol. 2
2 CD / Z Records (House/Disco) / 2016-03-04Tracks: I Love Music [Joey Negro Sweet Music Mix] - (remix); Music Is My Way of Life [Joey Negro Funk in the Music Mix] - (remix); Come Go With Me [Joey Negro Found a Place Mix] - (remix); Keep the Fire Burn...
Artists: Joey Negro
Audio Remixer: Joey Negro.
Liner Note Author: Dave Lee ....continue...
Elliott Power: Once Smitten
1 CD / Marathon Artists / 2016-03-04Artists: Elliott Power
Santigold: 99 Cents
1 CD / Atlantic (Label) / 2016-03-04Artists: Santigold
In the eight years between Santigold's self-titled debut and 99 Cents, artists who ignored the boundaries between genres -- as well as the mainstream and the underground -- became more fashionable and...continue...
Submotion Orchestra: Colour Theory [Digipak] *
1 CD / Counter / 2016-03-04Tracks: Red Dress; More Than This - (featuring Billy Boothroyd); Kimono; In Gold; Amira; Needs - (featuring Andrew Ashong); Empty Love; Jaffa - (featuring Still); Illusions; Ao - (featuring Catching Flies)
Artists: Submotion Orchestra
Personnel: Ruby Wood (vocals); Simon Beddoe (trumpet, flugelhorn); Taz Modi (keyboards); Chris Hargreaves (bass synthesizer, bass guitar); Tommy Evans (drums); Danny Templeman (percussion).
Miike Snow: iii *
1 CD / Atlantic (Label) / 2016-03-04Tracks: My Trigger; Heart of Me, The; Genghis Khan; Heart Is Full; For U; I Feel the Weight; Back of the Car; Lonely Life; Over and Over; Longshot (7 Nights)
Artists: Miike Snow
Audio Mixers: Niklas Flyckt; Miike Snow.
Recording information: Blackmail Studios, Los Angeles, CA; Castle Strängnäs, Strängnäs, Sweden; Downtown Studios, New York, NY; Dunh...continue...
Kaytronik: Thee Album [Digipak]
1 CD / R2 / 2016-03-04Tracks: It's Your Life; Boy; Quiet Places in My Head, Pt. 1; Renegade Ha; Do It; Nice Mutha; I Say; Never Go; Dust Yourself Off; Ain't No; Quiet Places in My Head, Pt. 2; Holy (Let's Not Play); Forever Grate...
Artists: Kaytronik
Audio Mixer: Kaytronik....continue...
Santigold: 99 Cents
1 CD / Atlantic (Label) / 2016-03-04Tracks: Can't Get Enough of Myself - (featuring B.C.); Big Boss Big Time Business; Banshee; Chasing Shadows; Walking in a Circle; Who Be Lovin' Me; Rendezvous Girl; Before the Fire; All I Got; Outside the Wa...
Artists: Santigold
Personnel: Santigold (vocals).
Recording information: Atlantic Studios, Los Angeles, CA; Atlantic Studios, NYC; Downtown Music Studios, NYC; Echo Park Backhouse Studios, Los Angeles, CA; Eldora...continue...
Phaedra: Blackwinged Night
1 CD / Rune Grammofon / 2016-03-04Artists: Phaedra


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Comcast To Host Third Quarter 2013 Earnings Conference Call
www.cmcsa.com or www.cmcsk.com. Those parties interested in participating via telephone should dial (800) 263-8495 with the conference ID number 63826624.A replay of the call will be available starting at 12:30 p.m. ET on Wednesday, October 30, 2013 on the Investor Relations website or by telephone. To access the telephone replay, which will be available until Wednesday, November 6, 2013 at midnight Eastern Time (ET), please dial (855) 859-2056 and enter the conference ID number 63826624. To automatically receive Comcast financial news by email, please visit our Investor Relations website and subscribe to Email Alerts. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA, CMCSK) is a global media and technology company with two primary businesses, Comcast Cable and NBCUniversal. Comcast Cable is the nation's largest video, high-speed Internet and phone provider to residential customers under the XFINITY brand and also provides these services to businesses. NBCUniversal operates 30 news, entertainment and sports cable networks, the NBC and Telemundo broadcast networks, television production operations, television station groups, Universal Pictures and Universal Parks and Resorts. Visit www.comcastcorporation.com for more information.
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Brewing capacity would be a major issue to their bottling also, at least in the short term.Some quick math, in Honda's 16 Nov 2005 post he stated that the worthouse was at 30% capacity (10 stores being supplied), so roughly 34 stores could be supported at 100%.We're at 18 stores now, expect another 7-8 in '08 (26) and likely another 7 after that, to hit 34 restaurants. If GC were to bottle, they'd have to do it now, as they should be planning on having another worthouse online in less than 2 years, just using my fuzzy math.Bottling would be more feasible in another 2-3 years when the next worthouse is operational, and the chain has grow out off the midwest. By then extra worthouse capacity could be utilized for bottling without taxing the system.


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There are three things that I have begun to incorporate into my way of thinking as a caregiver. It started when I was in my early 20's and began to lightly step onto the caregiving path for my aging grandmother. My parents long ago started something, (now defunct), called 'Caregiving Matters' when my grandmother was ill, for the issue of creating...
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Caregiving Matters
November 25, 2014
Labeling Without Thought
November 25, 2014
A recent discussion with a nurse practitioner prompted me to think about the nature of labels. She argued that regardless of the label, the underlying condition of behavior consistent with that description remains unaffected by the label assigned. Naturally, I disagreed. Labels are descriptors: values to which we assign descriptions of...
That's Not a Real Diagnosis
November 25, 2014
"That's not a real illness." "I don't believe in mental health." "If you don't need medication, you must not really have bipolar." These are just a few of the long stream of comments from people in my life, the most recent being "You know, I don't think you're bipolar, I think you have cyclomania," because having a Bachelor's in psychology...
Would You Boast of Your Weakness?
November 20, 2014
We have a thing against weakness don't we… well I for one do. When I look at negative unhelpful patterns going on in my life, despite the apparent effort that I have put in to change – I feel so weak and whiny. I often hate listening to myself talk to others because I am thinking that they must be thinking, "Here we go again…" See that...
The Importance that International Survivors of Suicide Loss Day Should Have on the World
November 20, 2014
November 22, 2014 is International Survivors of Suicide Loss Day, a day that much of society most likely does not know anything about. The American Foundation of Suicide Prevention (AFSP) in recognition of a resolution that Senator Harry Reid introduced to the senate, pronounced the Saturday before Thanksgiving to be "Survivors of Suicide Loss Day...
Hey Jealousy
November 19, 2014
I have a friend who is an expert in her field. She is respected by the community and gives presentations from her knowledge base. She is also a talented artist and sells her painted wineglasses at many gift stores in the area. She plays the piano at her church every Sunday. She travels with her husband and two kids and they hike and camp regularly...
Getting Help
November 19, 2014
Getting help for my bipolar disorder was one of the hardest and best things I've done. I'm a pretty proud and independent person so opening up and making myself vulnerable was extremely daunting. I was in my third and final year of university when I knew something wasn't right. The familiar feeling of dark hopelessness had started to creep...
Sally Buchanan-Hagen
November 19, 2014
My name's Sally and I live in Australia. I'm 24, a nurse in the emergency department, an honours student and I have bipolar type I disorder. When I was 20 I was diagnosed with unipolar depression, but a few years later at 22 it was evident that I had bipolar. I was diagnosed with bipolar type II but in the months following that diagnosis I had a...
Resilience is defined as "the ability to become strong, healthy, or successful again after something bad happens" or "the ability of something to return to its original shape after it has been pulled, stretched, pressed, bent, etc." If you want a real-world example of something that's resilient, think of a Slinky.I think it's fair to say that...
Six Simple Things You Can Do
November 18, 2014
Be HopefulHope is crucial for recovery, and there is good reason to be hopeful when it comes to mental health challenges. The vast majority of us who get appropriate treatment and support get significantly better. This is good news, but it is also not news that has been told until recently. Hope is the ONLY predictor of recovery...


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What can we do if our baby hates riding in the car?
My 2 1/2-month-old hates the car. The crying begins as soon as I start driving. We've tried everything: adjusting the straps, using a blanket, not using a blanket, hanging toys from the handle ... nothing works. Occasionally he'll cry himself to sleep, but for the most part driving with him is a nightmare. Could he have motion sickness? What else can I do?
Posted: 04/18/2001 by a BabyCenter Member
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My child was the same. At 7 months we tried occupational therapy where they did various motion excercises to help him get used to linear motion in small amounts. But we had to drive to get there :(. It seemed to help, but it is hard to say how much was just that he grew out of it w time. It definitely helped him like swings which he hated before we started. By 1 he was okay in the car for 15 min drives if i played a dvd and by 15 months he actually started liking the car... Never thought that would happen!!! So there is hope but it might just take time... Sorry, I know it is hard to be stuck at home ESP if u have other kids you need to drive places!posted 09/19/2013 by sanseverino
I began reading through these posts because I am currently dealing with an 8 month old to absolutely despises being in the car. When I would buckle him into his Graco snug ride car seats to go for a walk in the stroller she was fine but when he would go into the car in that same car seat he would scream bloody murder.I thought that changing the seat to his big boy seat, an evenflow, would help things. I was wrong. I guess he hate being restricted any hate that she can't see his mommy but even in cases where I've sat in the back with him he still cries he wants out! So anyway, today I started singing the lullaby I put him to sleep with and IT WORKED!! he eventually woke up and I sang any crazy thing that came to mind but I think now that it's a familiarity thing. He needs mommy to let him know its OK, and maybe introducing him to the car seat prior to it being in the car would be a good thing to do too! I just thought I'd share this with anyone who stumbled upon the thread.posted 09/19/2013 by TheJacqie
We cracked the window open and it works like a charm! It's like an on/off switch for our little guy. Not sure if its the wind or white noise or a combination of the two but we're just thankful to have found something!posted 07/13/2013 by lindseymcampos
Our 9 month old is very anti when it comes to her car seat. Always has been. It has developed however, as we have tried new techniques, into something much more manageable. If your child becomes frantic as our used to then the best solution is to purchase "the Happiest Baby on the Block" cd. It comes with 6 very long (10-15min) tracks of different types of white noise. Babies are soothed by loud white noise that reminds them of the womb. We would turn the speaker on in the back and off in the front and turn it up to the volume of a hair dryer or vacuum and watch the magic happen. Worked 90% of the time to calm her down. At around 5 months she stopped having the frantic episodes in the car but continues to fuss considerably. I hate to turn to a DVD player as we like to avoid tv as much as possible around her. However, I youtubed the baby Einstein Mozart DVD and it was awesome. She was very interested and I think it may do the trick!posted 06/14/2013 by a BabyCenter Member
We had this problem, Jess is 19 weeks and started this ever since the hot weather has come in, I also think she was too squashed in the infant carrier. We solved it by getting a 0+ to 1 car seat which is a lot wider for her but still rear facing at the moment and also playing her favourite song (twinkle twinkle) in the car, beats me or her dad singing it now we have it on cd! Opening the windows for a wee while helped too. Just wanted to say also to all the mums who have bought the dvd players for the cars, I would have done that too so dont listen to the negative comments on here about it. I dont see the difference between moving pictures and sound on a screen to a talking moving and light up toy!posted 05/26/2013 by s_anderson2011
None of the comments helped. We tried everything suggested and what commentors said worked for their kid. If someone had told me their kid went nuts in the car the way our does, I would not have believed them. She just becomes an insane and unpleasent baby. Seeing that this is going to last us a couple of years, and the fact that the Pediatrician knows nothing, I am extremely discouraged. We are just going to have to learn to ride around with a miserable child who is beside herself. I hope we are not raising a crazy person.posted 05/10/2013 by maf98m
You can try... A new toy exclusively for car rides, like one that your tot can kick with his feet. You can try... Check the car-seat straps to make sure they're not too tight or chafing that thigh chub (but still snug enough to be safe). You can try... A mirror. Or, you can cut out pictures of babies or family members, and put them where your baby can see them. for more visit here: http://www.cleansweepcarwash.composted 04/11/2013 by farishah
Try opening the window by your baby a crack (even if it's cold out)--this worked for a friend of mine. If that doesn't help, and all this other advice doesn't work, you might just have to wait. Most babies who hate riding backwards (car sickness?, can't see?) will greatly improve at age one/20 pounds when they can face forward.posted 12/13/2004 by ChefMomB
My 2 1/2 month old has this problem too. We noticed this morning, after reading some comments last night on here, that if we removed the base of the carseat, it sits at a diff angle bc our LO has reflux and he did 100 times better!! We don't have 200 for a britrix so I had to get creative! Now the only time he cries is when we are on a rough road, so I am going to sew in some extra padding!! Hope this helps some of you!!!posted 02/15/2013 by sara192
My 2 1/2 month old has this problem too. We noticed this morning, after reading some comments last night on here, that if we removed the base of the carseat, it sits at a diff angle bc our LO has reflux and he did 100 times better!! We don't have 200 for a britrix so I had to get creative! Now the only time he cries is when we are on a rough road, so I am going to sew in some extra padding!! Hope this helps some of you!!!posted 02/15/2013 by sara192
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New restaurant-bar planned for Nanakusa space
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Oh yeah, since Nanakusa couldn't hack it, let's bring in a blander, suburbanized version - surely that will fix the problem.
Wasabi has the best sushi in the State. This will be a huge upgrade from Nanakusa. I can't wait.
Agreed, Wasabi has the best fish in town and Park knows his business. I drive 30 minutes to Brookfield to eat at his place. Can't wait for him to open!
We feel Wasabi is the best sushi bar in town, bar none.The owner is cordial, the servers are very knowledgeable. The chefs are skilled and creative, the food is always beautifully presented and excellent in freshness and taste. They bring in specialities to which we've often been treated by sitting at the sushi bar and chatting with the chefs. In addition, the interior has a very attractive, urban vibe to it. I hope this doesn't mean they plan to close the Brookfield operation.
Uhhhhh.yeah.NanaKusa can never be topped as far as selection an authenticity of the cuisine.It was JAPANESE FOOD. I'm so sick of places opening up under the guise of "traditional Japanese" food, and then the menu is all flavored mayo filled maki and the3
Uhhhhh.yeah.NanaKusa can never be topped as far as selection an authenticity of the cuisine.It was JAPANESE FOOD. I'm so sick of places opening up under the guise of "traditional Japanese" food, and then the menu is all flavored mayo filled maki and the3
Excuse me 3 types of fish Americans eat...tuna, salmon, and hmmmmm Krab stix. I've eaten at Wasabi.it was ok.but they were selling tilapia and calling it snapper.can't stand Japanese posers!
morsel, try a big plate of escolar for the most delicious seafood you've ever eaten. I think this is also known a "super white."
- Wy'east Pizza opening on west side Thursday
- James Beard Award for best chef Midwest goes to Minneapolis chef
- East side's Good City Brewing hires Rumpus Room chef
- Bosley on Brady owner sells the restaurant
- Valentine Coffee to open a cafe-restaurant in Oak Creek
- Second screening with supper-club documentary filmmaker added at Drink Wisconsinbly Pub
- Beard Foundation names its book, broadcast and journalism award winners
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Kids can join Blu, Jewel, and all their favorite Rio characters for a wild adventure in the book Rio 2: Vacation in the Wild, a retelling of the movie Rio 2. Blu and Jewel take their kids on a trip to the Amazon so that the kids can experience life in the wild instead of in the city. The book is adapted by Catherine Hapka and includes pictures straight from the movie.
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Additional Rio 2 books are available and sold separately.
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For the full mortgage Rate Trend Index, go to http://www.bankrate.com/RTIAbout Bankrate, Inc. (NYSE: RATE) The Bankrate network of companies includes Bankrate.com, Interest.com, Mortgage-calc.com, Nationwide Card Services, InsureMe, CreditCardGuide.com, Bankaholic, CreditCards.com and NetQuote. Each of these businesses helps consumers to make informed decisions about their personal finance matters. The company's flagship brand, Bankrate.com is a destination site of personal finance channels, including banking, investing, taxes, debt management and college finance. Bankrate.com is the leading aggregator of rates and other information on more than 300 financial products, including mortgages, credit cards, new and used auto loans, money market accounts and CDs, checking and ATM fees, home equity loans and online banking fees. Bankrate.com reviews more than 4,800 financial institutions in 575 markets in 50 states. Bankrate.com provides financial applications and information to a network of more than 75 partners, including Yahoo! (Nasdaq: YHOO), America Online (NYSE: AOL), The Wall Street Journal and The New York Times (NYSE: NYT). Bankrate.com's information is also distributed through more than 500 newspapers.
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Cash, guns stolen from farmPublished 9:39am Monday, April 7, 2014 Updated 11:39am Monday, April 7, 2014
Two buildings at a Clitherall farm were broken into within the past week, according to the Otter Tail County Sheriff's Office.
A thief forced entry into two buildings in the 21700 block of 425th Avenue and stole $600 in cash and two handguns. Authorities photographed shoe prints in the yard and vehicle tracks in the driveway.


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The Sunday Age Picture Editor, Danie Sprague selects the best images from around the world today on the wires.
Scenes from Alan Ray Oval as Ainslie take on Queanbeyan in the local Australian rules football league.
Scenes from Carrington Park in Penrith as the Canberra Raiders take on the Penrith Panthers.
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Crowds gathered at 109 O'Connor Circuit in Calwell to see the urban sanctuary 'Carol's Garden'.
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Laotian Leader
As the Storm Lake Community School District celebrates another milestone with the hiring of North Elementary's newest third grade teacher, Dep Ung's current concern rests with preventing the first-day jitters.
Recently hired as the first certified Laotian teacher in the school district, Ung will take the helm of a third grade section as part of last spring's approval by the Board of Education to consolidate North and East elementary schools.
By no means a stranger to the district, Ung worked for the past 10 years as an English as a Second Language instructor and a classroom instructional assistant at North and East schools. As ESL instructor, Ung served as not only a teacher and interpreter, but also as a liaison between the Laotian community and the school district.
"The role has changed greatly over the years," Ung said. "It started with taking kids to the dentist and things like that, and it's really evolved into helping entire families adjust to living in the community."
In efforts to earn teaching certification, Ung took classes at Iowa Central Community College three years ago, and was later chosen as a recipient for the Career Ladder Grant, a program offered by the state of Iowa to aid minorities with educational expenses in order to achieve higher certification. With the grant, Ung attended classes at Iowa Lakes Community College and Buena Vista University Learning Centers, eventually earning her teaching degree last May.
Ung, who, with her husband, Wa, has two children, Melanie and Matthew, said that despite balancing school, work and family, her education and certification were worth it.
"I really enjoyed my time doing it," Ung said. "I had the advantage of working in a school, so I pretty much know what's going on. I also had wonderful teachers that I observed and learned from."
The eighth of ten children, Ung arrived to the United States with her family in 1975 after crossing the Mekong river and staying in a Taiwanese temple while fleeing from government oppression in Laos. The family lived on a military base in Arkansas and later relocated to Iowa City, assimilating to America while sponsored by the West Branch Lutheran Church.
Ung said that while she does plan to share many aspects of her Laotian heritage with her students, her main goal will be to teach not only reading and writing to her students, but also tolerance and awareness.
"Our community is so diverse, so by teaching, I hope to be a role model for not only minority students, but to teach all of my students that the world is filled with so many colors," Ung said. "I really want to bring awareness into my classroom."
Ung said that while she feels she will have a grasp on how the classroom operates thanks to her previous experience, there's no denying that butterflies.
"I'm very nervous about being on my own for the first time, but it's fair to say that it's a typical teacher thing," Ung said.
"I've been having some nightmares, but even experienced teachers are telling me it still happens to them. That helps a lot."


text: "My point is I've got no bias against it*, quite the contrary, and I was literally stunned** by what I read in that Reuters report. Because if it weren't for capitalism, there wouldn't be a Catholic Church***." * "no bias against it" appears to, in fact, mean "no knowledge of it". Now that he is [Read More…]