text:
BLENHEIM, N.Y. (AP) " U.S. utilities see great potential in the use of remote-controlled drones to do the often-dangerous work of inspecting power lines and transmission towers but strict regulations have so far slowed adoption of the technology.
ORONO, Maine (AP) " Builders of everything from cruise ships and ports to oil rigs offshore wind turbines are tasked with the same question " will their work will be strong enough to stand up to the sea?
BRUSSELS (AP) " The latest on the deadly attacks in Paris and the heightened security in Europe (All times local):
BUENOS AIRES, Argentina (AP) " Rising crime, soaring prices and proposals to bring Latin America's third largest economy out of a funk were some of the issues Argentines were considering during Sunday's presidential runoff election, seen as a...
WASHINGTON (AP) " With time running out on open enrollment season, many seniors are facing sharply higher premiums for Medicare's popular prescription drug program. The reason: rising drug costs have overtaken a long stretch of stable premiums.
BRUSSELS (AP) " Western leaders stepped up the rhetoric against the Islamic State group on Sunday as residents of the Belgian capital awoke to largely empty streets on the second day under the highest threat level.
WASHINGTON (AP) " Republican Donald Trump says he might run as an independent candidate for president in 2016.
BAMAKO, Mali (AP) " The latest on the attack on a hotel in the Malian capital of Bamako. (All times local):
BAMAKO, Mali (AP) " The assault on a luxury hotel in Mali's capital that killed 19 people was a clear attempt to derail a fragile peace process meant to stabilize the country's volatile north, a representative of northern separatist groups said...
BEIRUT (AP) " Syria's president says his forces are advancing on "almost" all fronts thanks to Russian airstrikes that began nearly two months ago.
MOSCOW (AP) " Two electricity transmission towers in Ukraine were damaged by explosions, leaving most of the nearly 2 million people on the disputed Crimean Peninsula without power on Sunday, the Russian Energy Ministry said.
Ionia Directory
Business Name
Location, ST | website.com


text:
A: Yes. Honda made some solid improvements to the 2016 CRF250, most notably in top-end power and suspension compliance; however, Honda's 2016 mods seem a little like closing the barn door after the horse has bolted.
A: Honda didn't rest on its laurels with the 2016 CRF250, largely because the lowly 2015 CRF250 didn't have any laurels. It was a mid-pack finisher in the "2015 MXA 250 Shootout." So, Honda spent time and money working on the 2016 engine and suspension.
(1) Engine. To increase power for 2016, Honda made a number of changes to the CRF250 engine, including lightening the piston and connecting rod, switching to titanium exhaust valves, revising the intake and exhaust port shapes, upping the valve lift, DLC-coating the buckets, adding an exhaust resonator to the head pipe, increasing the diameter of the muffler's perf core, bumping up the compression (from 13.5:1 to 13.8:1), revising the air-boot shape between the filter and throttle body, putting a roller bearing on the shift-drum stopper and increasing the fluid capacity of the left radiator.
(2) Chassis. The frame and its accoutrements remain unchanged except for the longer fork legs, new anti-mud footpeg scrapers and a 4mm-smaller-diameter chain roller (34mm instead of 38mm).
(3) Forks. For 2016 the CRF250 retains Showa's Separate Function Fork Triple Air Chamber units (SFF TAC in acronym-speak). The forks have more in common with the Kawasaki version of the TAC forks than the Suzuki RM-Z450 forks but differ from both in that:
(a) Lefty: They don't house the air pressure in the right fork leg but in the left one instead.
(b) Clickers: With the air on the brake-side fork leg, the damping and clickers are on the right fork leg.
(c) Hidden chamber: They don't use a piggyback balance chamber but instead tuck the balance chamber inside the left fork leg with both the main and outer chambers.
(d) Schrader valve: Last year Honda didn't put a Schrader valve on the outer chamber, or recommend any pressure in it, but this year there is a Schrader valve and an air pressure recommendation.
(e) Mellow breeze: Compared to the 2015 fork settings, the air pressure has been reduced for a suppler feel.
(f) Daddy long legs: The 2016 fork legs are 5mm longer than the 2015 legs, but this was done more for the 2016 CRF450 than for the CRF250.
(g) Incremental: The clicker adjustments have been made more incremental (it now takes eight clicks to do what four did last year).
2016 Honda CRF250: The massaged 2016 CRF250 engine produces more power on top and a modest increase in peak horsepower.
A: The major difference between the 2016 Honda CRF250 and the 2015 CRF250 is in the top-end power. Last year the CRF250 engine was a mixed bag. The power was manageable but not abundant. The power delivery was nice from low to mid but flat on top. The 2015 CRF250 engine was the perfect 250 Novice powerband. In plain language, it was slow, didn't rev and lacked serious horsepower. It fit perfectly into Honda's very strange "slow and steady wins the race" corporate philosophy. It should be noted that "slow and steady" also loses shootouts and sales.
Short of designing a new engine, which is hopefully on the Honda engineers' wish list, Honda pulled out all the stops with mods to the 2016 mill (piston, valves, rod, buckets, compression and valve lift). And while you can't always turn a sow's ear into a silk purse, you can gussy it up a fair bit. And that is what Honda achieved with the 2016 CRF250. Honda managed to add top-end power and over-rev without giving all of the low and mid back. This is commendable, mostly because it is almost impossible to do successfully.
A: Which do you want first? The good news or the bad news? Excellent choice.
The good news. Compared to the 2015 Honda CRF250, the 2016 CRF250 makes 1.6 horsepower more at peak. Better yet, from 10,000 rpm on it gaps the 2015 model by leaps and bounds. At 10,000 rpm the 2016 CRF250 is 0.28 horsepower better than its 2015 counterpart. At 11,000 rpm it is 0.64 horses ahead. At 12,000 rpm it is 2.70 horsepower better, and at peak (11,700 rpm compared to 11,000 rpm) the 2016 CRF250 is making 38.89 horsepower to the 2015 CRF250's 37.30 horsepower. Good stuff, especially because it is good where last year's CRF250 was bad—on top.
The bad news. Honda's sudden interest in making horsepower is too little, too late. These would have been good numbers five years ago, but they are weak sisters in 2016. At 11,000 rpm the Husqvarna FC250 makes 2.7 horsepower more than the Honda. At 12,000 rpm the Husky is pumping out 3.6 horsepower more than the CRF250. By 13,000 rpm, the Husqvarna has a 6-horsepower advantage over the CRF250. The final important number is peak horsepower. The 2016 Honda CRF250 makes 38.89 horsepower at peak, while the Husky FC250 produces 44.34 horsepower. In dyno terms the Husky is taking candy from a baby.
A: It is faster than last year's engine, but it just isn't a contemporary powerband. While it revs higher and hangs on longer, the feel of the powerband is hyperkinetic. It turns over very quickly and runs through its power output in half the time of the stronger and broader powerbands. You find yourself shifting constantly to stay in the narrow bubble. There is nothing to recommend about the 2016 CRF250 in the low-to-mid transition because this year's focus was on 10,000 rpm and up. But, every test rider said the same thing: "It makes more power on top, but it's over too quickly."
This engine, even with its mods, is fighting with the Suzuki RM-Z250 to stay out of last place in the 250cc four-stroke engine lotto. Neither the red nor yellow powerplants have the horsepower, breadth, usability or pizzazz of the green, white, blue and orange engines. Sad but true.
A: The engineers wanted to put a new frame under the 2016 CRF450, but they didn't have the budget. Their solution? They lengthened the fork tubes by 5mm. Why did they do that? It lifted the head tube, which slackened the head angle, moved the weight bias rearward and increased the trail. The result was a slightly calmer chassis at speed and on the entrance to turns. It is the poor man's frame fix, which leads us to the 2016 CRF250 chassis.
The 2016 CRF250 got the same long fork legs, but, unlike the CRF450, where Honda insists, in the owner's manual at least, that owners slide their forks all the way down to the caps, the CRF250 forks can be moved up and down to suit track conditions (not that the CRF450 forks can't be moved by enterprising racers). The basic setup is to start with the forks 5mm up in the clamps. In good conditions the CRF250 tries to channel its inner RM-Z traits; however, just like the RM-Z that it emulates, when the traction isn't as good, the speeds are high or the track is rough, the CRF250 is very busy. There is lots of twitching, head shaking and considerable wandering. In these situations, we slid the forks down in the clamps to the same fork height as recommended on the 2016 CRF450.
It should be noted that apart from the twitch, every MXA test rider felt at home on the CRF250 chassis. It felt light; it felt right.
Appendage: "Fashion over function" best describes the Honda CRF250's twin mufflers.
A: Here are our target changes on the day we move into the big office:
(1) Honda culture. We'd build the most powerful engine in the 250 class—not one that gives up 5 horsepower to a European bike.
(2) Twice pipes. We'd drop-kick the twin mufflers for a single-sided exhaust system. Not only would we gain power, we'd lose weight.
(3) Clutch. Honda has been sucking wind in the clutch department for years, but it became more obvious once KTM showed the world how long-lasting a clutch could be. We'd end the suffering of the CRF250's soft, spongy and weak clutch.
(4) Chain. We'd quit spec'ing the cheapest chain we could find. Does Honda think that the buyers don't know the difference between a good chain and a bad one?
(5) Forks. We'd call Kayaba and ask how much it would cost to put SSS coil-spring forks on the CRF250—and then pay them whatever it takes. Oh, don't get us wrong, we think the Showa SFF TAC air forks work adequately, but they are too complex for the typical teenage 250 four-stroke owner to live with. Don't worry about the weight of the coil springs, we'll save more than that when we get rid of the extraneous muffler.
A: With Yamaha and KTM setting the gold standard at 221 pounds, the 2016 Honda CRF250 took a dive in this category. Without its twin mufflers and pipes, the CRF250 could easily be 3 pounds lighter; however, Honda insists on sticking with the complex, expensive and heavy twice-pipes. The result? The 2016 CRF250 weighs 224 pounds, which just happens to be 3 pounds more than the KTM 250SXF and Yamaha YZ250F.
We don't like Honda's twin mufflers and never have. Don't forget they were on the CRF250 once before—from 2006 to 2009—before being resurrected in 2014. They don't make more power, made all the more obvious by the horsepower differential to the single muffler of the 2016 Husqvarna FC250. They aren't quieter, especially since Honda has a prescribed sound limit that every production bike must meet regardless of how many mufflers it has. They cost more to replace and repair, while doubling the chance of damaging them in a crash. If you're buying an aftermarket pipe for your 2016 CRF250, you'd be smart to look at a singe-sided system. It will be $500 cheaper.
A: Honda has three ignition maps that can be selected by pressing a button on the throttle side of the handlebars. Depressing the map button for one second switches the ignition curve to the mellow map. This is distinguishable by two consecutive blinking lights, which repeat three times. Holding the map button down for an additional second switches the ignition curve to the aggressive map. Three lights blink consecutively and repeat three times. Holding down the map button for another second will switch the map back to stock (and a single blue light will flash). In truth, the aggressive map (three blinks) was the unanimous choice of every MXA test rider—from Beginner to Pro. This map should be the stock map. It doesn't make more power in this setting, but throttle response is improved and the CRF250 feels crisper.
As for launch control, the 2016 Honda doesn't have launch control. No sweat. A 38.89 horsepower, 250cc four-stroke really doesn't need launch control.
A: The hate list:
(1) Engine. When you see the list of changes that Honda's engineers made to the 2016 CRF250 engine and the added top end on the dyno chart, you assume that good things will naturally follow on the racetrack. Strangely, they don't.
(2) Dual mufflers. At least they look cool, but they are more detriment than boon.
(3) Side panels. It's tough enough to install preprinted numbers on a flat number plate panel, but two side panels, both with complex curves, defy putting on wrinkle-free number plate backgrounds. Good luck.
(4) Chain. From whence the phrase "weak link" comes.
(5) Head-shake. When the CRF250 gets twitchy in the rough, it will require your best jazz-hands imitation to keep up with it.
(6) Frame cradle. Imagine a motorcycle that doesn't sit flat on a stand. The frame cradle is to blame.
A: The like list:
(1) Target audience. Honda isn't going to tell you this, but the 2016 Honda CRF250 is at its best in the hands of Beginners and Novices. Faster riders can muscle the bike around with impunity, but muscle is what this engine lacks—in a class that is all about strength.
(2) Ergonomics. The CRF250 feels comfortable regardless of your stature. The CRF250 ergonomics are quite pleasing right off the showroom floor. An open cockpit, narrow frame, neutral handlebars and flat seat profile are creature comforts that are well-liked by every tester.
(3) Front brake. Still not up to the KTM/Husqvarna pedigree, the 260mm oversize front rotor has better bite than the old brake.
(4) Forks. The only major quibble about the Showa SFF-TAC forks is that the average rider will not fully understand the intricacies of setting and checking multiple air pressures before every ride.
(5) Engine Mode Select. Options are always nice, as are brightly colored flashing lights.
(6) Durability. The CRF250 takes a licking and keeps on ticking.
(7) Steering stem. We go all in on the HPSD steering damper clicker, but don't be afraid to crank down on the steering-stem nut also. Tighten it until excess slop is gone when applying light pressure to the bars.
A: My how the mighty have fallen. The juxtaposition of Honda and KTM on the priority scale from 10 years ago to today is startling. If you believe that the meek shall inherit the earth, look no further than KTM and Honda. The top dog is now looking up to the puppy it used to push around.
This is how we set up our 2016 Honda CRF250 for racing. We offer it as a guide to help you get your own bike dialed in.
Last year Honda only put Schrader valves on the inner and balance chambers. This year they added a Schrader valve to the outer chamber and even suggest putting air in it. What's the benefit of air in the outer chamber? The outer chamber can be used for bottoming control. Last year's recommended air pressures were much higher (174 psi inner and 170 psi balance) than this year's 156 psi. Our 2016 test bike came with a sticker on the left fork leg that lists the recommended air pressures. But, more important, the sticker has a glyph that must be used to determine which air pressure goes where. Without the pictogram-style glyph, you will most likely put 156 psi in the Schrader valve that requires 12 psi. For hard-core racing, these are MXA's recommended 2016 Honda CRF250 fork settings (stock settings are in parentheses):
Inner chamber: 156 psi
Outer chamber: 8 psi (12 psi)
Balance chamber: 156 psi
Compression: 6 clicks out
Rebound: 18 clicks out (24 clicks out)
Fork-leg height: Flush with top clamp
Notes: Focus on getting the air pressure dialed in for your weight and track. Leave the clickers in the stock positions until you have the perfect spring rate, then move on to the clickers.
Here is what the MXA wrecking crew ran in its 2016 CRF250 (stock settings are in parentheses):
Spring rate: 5.3 kg/mm
Race sag: 105mm
Hi-compression: 2-3/4 turn out (3 turns out)
Lo-compression: 10 clicks out (10 clicks out)
Rebound: 6 clicks out (8 clicks out)
Notes: The shock is very sensitive to high-speed compression. Every rider should go in 1/4 turn on the high-speed compression. Heavier riders should set the sag at 100mm instead of 105mm.

subset: commoncrawl


text:
Dirty Birds Cause Salmonella Outbreak In MichiganThe Michigan Department of Health and Human Services on Monday reported 20 cases since March 2 through direct contact with live baby chicks or ducklings.
Recall: Organic Herbal Tea Sold At CVS May Contain SalmonellaTea drinkers, take note.
Safety Tips For Dyeing Easter EggsColored eggs are emblems of Easter. But eggs, when not handled with special care, can cause food poisoning.
Wonderful Pistachios Recalled Over Possible Salmonella ContaminationIt's time to check your pantry.
Bravo Brand Dog & Cat Food Recalled After Test Finds SalmonellaBravo Pet Foods is recalling four of its products due to concerns about the possible presence of Salmonella.
Blue Buffalo Recalls Bones Sold At PetSmart Due To Potential Salmonella ContaminationIf you're a pet parent who shops at Petsmart, you'll want to pay attention to this recall.
Dole Recalls Bagged Spinach Due To Salmonella RiskThe possibly tainted spinach was distributed in Michigan and 12 other states.
Officials Investigate Salmonella Outbreak At Detroit HospitalMore than a dozen patients are affected and those still hospitalized are being kept isolated as a precaution.
Kroger Recalls Several Spices Found Tainted With SalmonellaCinnamon, garlic powered, black pepper and bacon bits are all included.
Frozen Chicken Sold At Meijer, Wal-Mart, Kroger Recalled Due To SalmonellaAn expansion of an earlier recall, this brings the amount of included products to 1,707,494 pounds.
Macadamia Nuts Recalled Over Possible Salmonella ContaminationIt's time to check your pantry.
Trader Joe's Recalls Raw Walnuts Due To Possible Salmonella ContaminationRoutine testing by an outside company contracted by the FDA showed the presence of Salmonella in certain packages of Trader Joe's Raw Walnuts.


text:
We could go on and on about Gate City Billiard Club and it's clean, spacious interior, immaculate tables, arcade games, and full service bar, but don't take our word for it -- take a tour and we're sure you'll come away feeling the same:
• $8 ($16 value) for two hours of pool on one table for any amount of players
• $80 ($160 value) for a two-hour private billiards room rental for up to 75
• Private room includes two nine-foot pool tables, ping pong, and four dart boards
"Great tables and the best competition around ..." - Google Reviewer
More Reasons to Love This Place
This Greensboro pool hub has it all. From the 11 9-foot Crown IV pool tables and three 7-foot diamond pool tables to the game room stocked with a ping pong table, darts, and video games, we're not sure you'll ever want to leave. And you might not have to since the club also features a full-service bar with all the best brews on tap, and big-screen HD TVs with DIRECTV sports packages.
PAID VALUE EXPIRES ON May 3, 2021
PROMOTIONAL VALUE EXPIRES ON September 17, 2014
Buy this Deal with confidence, because it's covered by the LivingSocial Good Deal Guarantee up to the Voucher Expiration DateSee Details »
Gate City Billiards Club
Two Hours of Pool on One Table or a Two-Hour Private Billiards Room Rental for Up to 75 People
enjoy $8 savings
- from $8


text:
Suffolk University, located in Boston, Mass., is a private institution founded in 1906. Situated in the historic neighborhood of Beacon Hill, Suffolk is now the third largest university in Boston. The academic programs allow students to pursue their interests while learning in a personal, hands-on environment. The unique downtown location affords many opportunities for internships and co-ops.
Are you ready to begin an undergraduate degree program now? U.S. News University Directory can
match you with top schools and accredited degree programs that meet your criteria in a few simple steps.
Get matched now!
Get help paying for school -- there are grants and scholarships that can offset your education expenses.
Sign up and you'll receive an email with instructions on how to download this information. Be sure to whitelist us to ensure delivery!
Has guaranteed admission agreement with at least one other institution: N/AGuaranteed admission agreement URL: N/A
associate degree, bachelor's degree, certificate, diploma, doctorate, master's degree, post-bachelor's certificate, post-master's certificate
Environmental science, Speech communication and rhetoric, Visual and performing arts, general, Radio and television broadcasting technology/technician, Interior design, Psychology, general, Computer and information sciences, general, Environmental/environmental health engineering, French studies, International business/trade/commerce, Advertising, Computer engineering, general, Humanities/humanistic studies, Journalism, Chemistry, general, Legal assistant/paralegal, Physics, general, Public relations/image management, Broadcast journalism, Mass communication/media studies, Information science/studies, Economics, general, Electrical and electronics engineering, Marketing/marketing management, general, Finance, general, Radiation biology/radiobiology, Foreign languages and literatures, general, French language and literature, English language and literature, general, Biology/biological sciences, general, History, general, Accounting, Entrepreneurship/entrepreneurial studies, Business administration and management, general, Organizational communication, general, Mathematics, general, Sociology, Latin american studies, Political science and government, general, Political communication, Asian studies/civilization, Theatre literature, history and criticism, Drama and dramatics/theatre arts, general, Spanish language and literature, Taxation, Philosophy, Computer science
Basic services offered: nonremedial tutoring, women's center, placement service, health service, health insuranceRemedial learning services offered: reading, math, writing, study skillsCounseling services offered: academic, birth control, career, minority student, older student, personal, psychological, religious, veteran studentCampus safety and security services offered: 24-hour foot and vehicle patrols; Late night transport/escort service; 24-hour emergency telephones; Lighted pathways/sidewalks; Controlled dormitory access (key, security card, etc)
Student activities offered: Campus ministries, Choral groups, dance, drama/theater, international student organization, literary magazine, model un, music ensembles, musical theater, radio station, student government, student newspaper, student film society, television station, yearbook
Intercollegiate varsity nonscholarship sports offered for men: Baseball, basketball, cross country, golf, ice hockey, soccer, tennisIntercollegiate varsity nonscholarship sports offered for women: Basketball, cross country, soccer, softball, tennis, volleyball
U.S. News University Directory can match you with Online Programs that meet your criteria in a few simple steps.


text:
Reviews for Hotel RichardAddress: 35 Rue Richard Lenoir, Paris, France
Rooms from: US$ 32.39
Ratings Explained
(Hostelworld.com and Affiliate sites)
The following reviews were submitted by customers who booked through our sister site, Hostelworld.com, in the last 12 months.
The ratings in the rating box are based on all-time feedback for the property and are the opinions of the customers who submitted them; they do not express the opinions of Hostelworld.com or our affiliate sites.
Overall Rating (8 Ratings)
Customer Reviews for Hotel Richard
savirellis5194, from USA ~ 25th Jan 2016
misstraina, from Portugal ~ 7th Oct 2015
gemmatolfo1563, from Australia ~ 23rd Jun 2015
firstclass99, from England ~ 24th Jul 2015
matsukatov938349, from Ukraine ~ 24th Jul 2015
cisleyortiz7642, from Mexico ~ 2nd Jul 2015
ThorstenEuler6791, from Germany ~ 8th Jul 2015
adamgod1623, from England ~ 22nd Jun 2015
grannies9201, from Latvia ~ 17th May 2015
blue13ceasar4077, from USA ~ 15th May 2015


text:
Kevon Cooper's magnificent 4-wicket haul rocked the Perth middle order and set the game up for Rajasthan. The man of the match stated that he had worked hard on his yorkers and was glad that it paid off well for him. Cooper picked up wickets in heaps and wreaked havoc on Perth in the middle overs. He first got rid of Hilton Cartwright and Ashton Turner in the 12th over before accounting for Joe Mennie and Ashton Turner off successive deliveries in the 18th. His lengths were particularly impressive and he pitched the ball up to the batsmen, Cartwright was trapped lbw off a yorker and Turner was cleaned up by a scorcher in the block hole. "It is good to come out here and bowl well. The first two games didn't go my way but I am happy that I did well today and my team won. I worked on my yorkers and it came off well for me. To be playing alongside Dravid, Watson and some of the young guys is a good feeling," stated an elated Cooper. Rajasthan skipper, Rahul Dravid was very pleased with his side's performance as Rajasthan sailed into the semi-finals with three wins from as many matches. It was a comprehensive 9 wicket victory for the home team with plenty to spare. Dravid acknowledged that the win was set up by his bowlers. Kevon Cooper was the pick of the bowlers with 4 wickets and was given excellent support by James Faulkner and Pravin Tambe who chipped in with 2 wickets each giving nothing away to the Perth batsmen. "It's nice to win and it's nice to play well. I thought it was a clinical performance today. We can always improve, we are always up against top teams. The bowlers pulled it off really well after they got off to a start," quoted Dravid. He further hailed the match-winning stand between Sanju Samson and Ajinkya Rahane after his own dismissal in the first over of the Rajasthan innings. "Sanju and Rahane ensured that there were no alarms after I got out in the first over. We are looking forward to take on Otago, it should be a great game of cricket. We are staying here and we would like to end on a high," added Dravid. Perth find themselves in the bottom of Group A with 2 losses from 3 games. Their skipper, Simon Katich admitted that their overall performance left much to be desired. He stated that the batsmen fell well short and the bowlers could not do much either after capturing Dravid in the first over. "We are learning the hard way. Unfortunately, we were no way near our best with the bat. Even though we got an early wicket we couldn't do much later," said Katich. Ashton Agar, Joel Paris and Ashton Turner all made their T20 debuts against the Lions in the rain-abandoned match in Ahmedababd whereas Burt Cockley earned his cap against Otago in the 62-run loss in Jaipur. "We presented four caps in the first two matches and it is very tough for those guys to do well straightaway in a big tournament like this. Hopefully we will do well back home in the Big Bash. We would like to do well in the last game and spoil others' party," added Katich. Perth play their last match against Mumbai in Delhi on the 2nd of October.
I worked on my yorkers: Cooper
Jaipur, Last updated on Monday, 30 September, 2013, 07:57 PM
Playing alongside Dravid and Watson is a good feeling: Cooper. © Cricbuzz
© Cricbuzz


text:
We are looking for someone with a high energy level who is confident in building partnership with potential client companies.This ideal candidate should have credible Hunter experience and have proven record in penetrating into new clients and talking to executive level people. This position requires individuals to be self-motivated, demonstrate initiative and enthusiasm in carrying out their responsibilities and possess a highly professional demeanor both in person and on the phone. • Responsible for Revenue generation and business development in the digital technologies
Accurately forecast annual and quarterly revenue streams. Plans, owns, and independently drives the sales strategy in conjunction with the Senior Management
• Meet the assigned revenue targets.
• Conduct research into target clients.
• Increase deal size and penetration
• Participate in marketing events.
• Understanding the gaps in our experience and proactively filling them
•Forecasting trends in the industry and pro-actively
. Acquire relevant / pilot clients to build case studies
Required Skill set:
Please share your resumes @ firstname.lastname@example.com
Job Description:
1. Should have 7+ yrs of experience in Core Java with Spring (IOC and MVC).
2. Hands on RESTFUL Webservices(Producing Restful)
3. Knowledge on TDD(Test Driven Development)
Primary Skills:
Personal Skills and Qualities:
Desirable Skills:
Should have 6+ experience in .net C#
2-3 years' experience in windows development
Willing to learn new technologies
Good communication skill
Able to work individual with ownership and also in team
Knowledge of system design/architecture of his/her project
Experience or knowledge in AUTs
Experience in Entity Framework
Experience in WCF or restful services
Working in Agile process
Working with third party controls
Required Skills
• Experience in ASP.NET MVC, JQuery,
Entity Framework, Web API & REST Services
C#, Automated Unit Testing (MS Test, NUnit)
Mocking Frameworks – TypeMock, MoQ, RhinoMock
Dependency Injection of IoC tools – AutoFAC, StructMap
• Design and development of online (web)systems
• Analysis of current programs including performance, diagnosis and troubleshooting of problem programs, and designing solutions to problematic programming
• Able to understand and make the client understand there questions and take lead in client discussion
• Discuss challenges / approaches / solutions with the internal and onsite team effectively
• Able to work independently.
• Learn new technologies and tools.
• Responsible for writing unit test cases
• Strong in communication skills
• Write defensive code
• Write structured code end to end
• Able to work independently and in team
• Should Able to work from 8.30 AM
1. Should have hands on experience on integration and porting of Verimatrix, Google and Adobe CAS/DRM.
2. Expertise in Google DRM (WideWine DRM) Framework
3. Expertise in Adobe (ES2/ES4/DRM)
4. Expertise in Verimatrix (VCAS 3/Ultra)
5. Understanding of Copy control, Video Conditional Accessing Systems, Video Watermarking, cloaked CA, smart card, CI plus.
6. Should possess Excellent Programming skills in C/C++ or java
7. Should have hands on experiance in porting third party CAS & DRM content security solutions
8. Should have working Experience in STB Application development.
9. Estimate and plan development tasks, improve development processes and tools to meet corporate targets.
10. Integration and porting experience on Verimatrix(VCAS 3/Ultra), Google(WideWine DRM) and Adobe(ES2/ES4/DRM) content security solution (CAS /DRM)
11. STB Application Development domain knowledge
Requirement details:
Should have 3+ experience in .net C# & OOPs
1 years' experience in windows development
Willing to learn new technologies
Good communication and analysis skills
Able to work individual with ownership and also in team
Knowledge of system design/architecture of his/her project
Good to have:
Experience or knowledge in AUTs
Working in Agile process
Experience in restful services
Working with third party controls
Copyright © 2016
ValueLabs. All rights reserved.


text:
Armilda Sue Heathington, 76, of Kennett, died Monday, June 7, 2004, at Baptist Memorial Hospital in Blytheville, Ark.
Born Dec. 19, 1927, in Gid, Ark., daughter of the late Walter and Ora Caraway Adkisson, she was a homemaker and a member of the First Baptist Church in Hornersville, Mo.
On Nov. 12, 1946, in Cushman, Ark., she married James B. Heathington, who preceded her in death.
Survivors include one son, Larry Heathington and wife, Shirley, of Kennett; one sister, Celda Engles, of Guion, Ark.; one brother, Jackie Adkisson, of Batesville, Ark.; five grandchildren and seven great-grandchildren.
Graveside services were held at 2 p.m. today, Tuesday, June 8, at the Horner Cemetery in Hornersville with the Rev. Doug Clinton officiating.
Bradshaw Funeral Home of Kennett was in charge of arrangements.


text:
FLAGSTAFF — The U.S. Environmental Protection Agency has imposed new pollution limits on three coal-fired Arizona power plants, aiming to protect the environment and air quality for wilderness areas and landmarks such as the Grand Canyon.Read More »
Tag Archives: Grand CanyonFeed Subscription
Veit Springs: A Home on the Mountain
An early resident in the Flagstaff area was German Ludwig Veit (pronounced Wait) who homesteaded at 8,500 feet on a slope of Mt. Agassiz, one of the peaks of San Francisco Mountain. He received a patent to the 160-acre parcel in 1891. Two springs and a relatively flat area to farm prompted Veit to select the unlikely spot where he and his family lived for two decades. Their nearest human neighbors were five miles away in Hart Prairie or Fort Valley, many of whom were also of German descent. The property then became a bird study area and later, the Lamar Haines Memorial Environmental Study Area.Read More »
Colter and Colton: The architect and the artist
In addition to sharing very similar names, Mary Colter and Mary-Russell Ferrell Colton both used their artistic talents to leave lasting impressions on northern Arizona.Read More »
Mohave County official urges Congress to lift Grand Canyon mining ban
The chairman of the Mohave County Board of Supervisors called on the federal government Tuesday to revoke a recently imposed 20–year ban on uranium mining near the Grand Canyon.Read More »
Salazar confident uranium-mining ban will withstand legal challenge
Interior Secretary Ken Salazar said Tuesday he is confident a 20–year ban on uranium mining near the Grand Canyon will hold up to an industry lawsuit challenging the January withdrawal of the land by federal officials.Read More »
Uranium mining in the Grand Canyon region is unwise
I'm not an environmentalist and I don't understand all of the environmental issues, but I do understand that we get 5 million people coming to the Grand Canyon every year. Tourism is not compatible with mining or with the mining trucks transporting uranium to be processed in Utah, and generally running the risk of despoiling this national treasure.Read More »
Bringing Water to the South Rim
Common sense dictates that settlement near the south rim of the Grand Canyon should never have occurred, as the area lacks a permanent groundwater supply. As part of the Coconino Plateau, the rim slopes away from the canyon toward the southwest and precipitation drains away from the edge of the gorge. Yet the mystique and splendor of the Grand Canyon have always drawn adventurers and the curious, which ultimately led to the establishment of a community known as Grand Canyon Village.Read More »
US bans new mining claims near Grand Canyon
The Obama administration is banning new hard rock mining on more than a million acres near the Grand Canyon, an area known to be rich in high-grade uranium ore reserves.Read More »
Conservationists challenge mine near Grand Canyon
A federal judge's decision to allow a uranium mine to operate under an existing plan is being challenged.Read More »
Repeal of 'Clean Cars' program nears finish line
Despite steep opposition from environmentalists and consumer advocates, the Brewer administration is pushing ahead with the adoption of a less stringent standard for curbing car emissions.Read More »


text:
Why do single people become poly?
View Single Post
Senior Member
Join Date: Nov 2009
Location: Metro West Massachusetts
Posts: 5,091
Originally Posted by
but an "fair" relationship between 3 people to me would be three people considering the needs of, well, three people. .
But you're not in a triad. Your h has a gf. She is not your lover, or even your close friend, just a metamour. If you feel like you're acting like a doormat to make it easier for your h and her to get together, STOP. Never mind you think she's a fancy free single. Your h isn't. He is a husband and a dad. You can have expectations of him to do XYZ around the house before he goes to play with his friend.
Also, you could hire household help or a babysitter. You say your son is too old for a sitter but too young to be left alone? Hogwash. If he's too old to be left alone, he needs a sitter.
Love withers under constraint; its very essence is liberty. It is compatible neither with envy, jealousy or fear. It is there most pure, perfect and unlimited when its votaries live in confidence, equality and unreserve. -- Shelley
Mags, F, 60, poly-dating, loving and living with
miss pixi, F, 38
also seeing
Punk, 42, M (dating since Oct 2015)
and a few more casual relationships
View Public Profile
Find all posts by Magdlyn


text:
My daughter has been daytime trained for a year now, but still wet about half the time at night. We have tried going without a diaper/pullup to see if being uncomfortable helped, but it just ended up being a lot more laundry. Will she just outgrow it at some point? I have heard to restrict fluids, but on these hot days, she is thirsty. I'm not sure, but it doesn't seem like she can control it, although, maybe she just doesn't feel like getting up to go? She is dry at nap time, although that took a lot longer than days, even if she went just before she napped.
Potty trained for a year, but still wet at night
We just gota potty trained a couple months ago and she still wears a pull-up at night too. Some days it's dry, others it's wet. I'd rather have it on then have to wake up in the middle of teh night to change sheets and all.
But, my niece was similar to yours. She was PT at 2.5 and at 5 she was still needing a pull up at night. Finally her aprents just took the plunge. They bought those bed-time mats and used those. They also figured out that if she had any dairy after 5, it would make her wet the bed (interesting, eh?). So, they cut out all dairy after dinner. They also did no drinks at all after like 7. At 5yo, she was able to understand more than ous do now obviously. Anyhow, she was night trained pretty quickly. I guess it's just taking the plunge and doing it. I'd have a hard time ever telling my kid they can't have a drink tho.
BOY / GIRL TWINS due 11/10/15
I haven't seen the bedtime mats, I will try those. Interesting about the dairy. She usually does have milk with supper. Problem is, my husband doesn't get home until six, so supper is usually between 6 & 6:30, so it's hard it is hard to restrict by 5.
Wife to Eric & Mommy to Haydon Oscar
��� *~*I believe Elliana can fly*~*
� Our Smiling, Sleeping Angel- Eliza Rae
Nighttime "training" is mostly developmental. Some things, like limiting drinks, or limiting some thing that they are sensitive to, like dairy (for ds it seems to be juice, lemonade, etc. in the evening) will help. But mostly, you just have to wait. DS is dry almost every night, though he is up at least once most nights to go pee on the potty. My three older kids were dry every night by this age.
Lisa, homeschooling mama to
dd 9/04 ds 3/06 dd 1/08 ds 1/10 ds 2/12 ds 4/14 mc 10/15
I'm having this problem too! I think part of DD's problem is that she is such a heavy sleeper. She has been potty trained and dry at nap time for almost a year. After this package of pull ups are gone I wont buy anymore, as much as I dread the thought of daily sheet washing.
My little peanut Holly 1-8-10! Peanut #2 due 9/17/13!
After 2.5 yrs TTC, preggo with first kiddo; now Mum to Gabriel Logan Jan 2010; 6mo TTC #2=Zachariah Huxley 31913; Happily married since 06-25-05
After 2.5 yrs TTC, preggo with first kiddo; now Mum to Gabriel Logan Jan 2010; 6mo TTC #2=Zachariah Huxley 31913; Happily married since 06-25-05
Thanks everyone! She rarely wakes up in the night, so I'm not sure if she is going in the middle of the night in her sleep and doesn't even notice, or wakes up in the morning and doesn't get up fast enough. She can hold it a long time during the day though. She only drinks mile or water, but I will try restricting milk in the evening, but still let her have water and see if that makes a difference.
Learn more
Look how far your child has come.
Review your child's growth milestones.
Read about 6 years 2 months : Week 3.
Your growing child
Your 6 1/4-year-old: Getting good rest
Your 6 1/4-year-old: Black-and-white thinking
Your 6 1/4-year-old: Playing fair
Your 6 1/4-year-old: Table manners
Your 6 1/4-year-old: Making choices
Learn more
What's next for your growing child?
Get a glimpse of what's to come.
Read about 6 years 4 months : Week 1.


text:
77 Miles
124 Km
1 hour 20 mins
64 Miles
102 Km
38 mins
3.56 Gallons
Fuel Needs
0.91 Pounds CO2 fp per miles
Distance from Fritch, TX to McLean, TX is 77Miles or 124 Km. You can get this distance about 1 hour 20 mins. If you want to planning travel with plane, you can get this distance about 38 mins .
A car with an average MPG will needs 3.56 gallons of gas to get the route between these points.
The estimated cost of gas to get between Fritch, TX and McLean, TX is $8.08.
During the route, an average car will release 69.75 pounds of CO2 to the atmosphere. Your carbon footprint is 0.91 pounds of CO2 per mile.
* Average US MPG used for calculations is 21.6 MPG.
* Average US gas price used for calculation is 2.27 per gallon.
* Coordinates of Fritch, TX is 35.6398467, -101.603319 and coordinates of McLean, TX is 35.2325677, -100.59993739999999
All Rights Reserved. © 2010 - 2016 About Feedback


text:
Requires Adobe Acrobat Reader
20-2940 - Lint Free Wipes
High quality wipes are ideal for all types of general purpose equipment cleaning. Super strong, highly absorbent wipes can be used with mist cleaning solutions and solvents. Will not tear or degrade during use. Each wipe is 6" x 6", 75 wipes per package, 12 packag...
21-7800 - 8" x 12" Statshied® Transparent Metal-In Standard ESD Shielding Bags
Transparent metal-in ESD shielding bags are the most commonly used shielding bag. These bags allow for 40% light transmission for easy identification of bag contents.
MCM is a great company. Very fast service and shipping of Raspberry Pi. Will tell all my friends to buy from MCM


text:
March 2013, TruckingInfo.com - Feature
By Evan Lockridge
If you've been hoping there is an end in sight to California's tidal waves of increasing trucking regulations, unfortunately, the tsunami has yet to strike, unless it crashes in a legal challenge.
Tags: CARB, EPA, Low Carbon Fuel Standard, CTA
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
The expert, Mark Betner from CITGO, will answer your questions
The expert, Brian Fletcher from Eaton, will answer your questions
J.J. Keller Expands ELog Training for Drivers
Cotter Pin Designed to Prevent Brake Seizing
Mainstay Introduces Faster, Lighter, More Compact CNG System
Easy Operating Kin-Sider, Kin-Slider


text: Dunedin School of Medicine http://hdl.handle.net/10523/220 2016-04-29T19:50:10Z 2016-04-29T19:50:10Z Te Ohonga Ake The Determinants of Health for Māori Children and Young People in New Zealand Series Two Simpson, Jean Adams, Judith Oben, Glenda Wicken, Andrew Duncanson, Mavis http://hdl.handle.net/10523/6384 2016-04-28T22:14:54Z 2016-04-18T00:15:21Z Te Ohonga Ake The Determinants of Health for Māori Children and Young People in New Zealand Series Two 2016-03 Simpson, Jean; Adams, Judith; Oben, Glenda; Wicken, Andrew; Duncanson, Mavis This report, which focuses on the underlying determinants of health for Māori children and young people, aims to: 1. Provide a snapshot of progress in addressing many of the determinants of health including child poverty and living standards, housing, early childhood education, oral health, tobacco use, alcohol related harm, and children's exposure to family violence. 2. Assist those working in the health sector to consider the roles other agencies play in influencing child and youth health outcomes related to these determinants. In exploring the underlying determinant of health for Māori children and young people, each of the indicators in this year's report has been assigned to one of four sections: • The Wider Macroeconomic and Policy Context • Socioeconomic and Cultural Determinants • Risk and Protective Factors • Health Outcomes as Determinants A viewpoint by Dr Bridget Robson beginning on page 32 reflects on the findings of the report in the context of Māori economic values 2016-04-18T00:15:21Z The Determinants of Health for Children and Young People in New Zealand (2014) Simpson, Jean Oben, Glenda Craig, Elizabeth Adams, Judith Wicken, Andrew Duncanson, Mavis Reddington, Anne http://hdl.handle.net/10523/6383 2016-04-18T14:02:22Z 2016-04-18T00:14:45Z The Determinants of Health for Children and Young People in New Zealand (2014) 2016-03 Simpson, Jean; Oben, Glenda; Craig, Elizabeth; Adams, Judith; Wicken, Andrew; Duncanson, Mavis; Reddington, Anne This report, which focuses on the underlying determinants of health for children and young people in New Zealand aims to: 1. Provide a snapshot of progress in many of the areas covered by the HSC's Inquiry including: child poverty and living standards, housing, early childhood education, oral health, tobacco use, alcohol related harm, and children's exposure to family violence. 2. Assist those working in the health sector to consider the roles other agencies play in influencing child and youth health outcomes in each of these areas. 3. Assist those working locally to utilise all of the available evidence when developing programmes and interventions to address child and youth health need. in-depth topics focus on the importance of the very early years, and on developing whole-of-Government, inter-agency approaches to improving outcomes for children and families. Better Health for the New Generation: Getting It Right from the Start: This in-depth topic written by Amanda Kvalsvig, explores the complex ways in which maternal health and wellbeing during pregnancy and even before conception can affect child health. The Effectiveness of Integrated Services (Health, Educational and Social): This in-depth topic written by Nadia Bartholomew, explores the effectiveness of integrated services and how such programmes should be delivered to provide optimal benefit for children and their families. This report is based on an Indicator Framework developed during the first three years of child health reporting, with each of its indicators being assigned to one of four sections as follows: 1. The Wider Macroeconomic and Policy Context 2. Socioeconomic and Cultural Determinants 3. Risk and Protective Factors 4. Health Outcomes as Determinants 2016-04-18T00:14:45Z Identifying and Overcoming the Barriers to Smoking Cessation in Rheumatoid Arthritis Aimer, Phillipa Claire http://hdl.handle.net/10523/6375 2016-04-13T14:02:09Z 2016-04-12T23:04:52Z Identifying and Overcoming the Barriers to Smoking Cessation in Rheumatoid Arthritis 2016 Aimer, Phillipa Claire The association between smoking and rheumatoid arthritis (RA) is well established. The risk of developing RA is higher among smokers. Smoking may also affect the severity of disease and reduce the efficacy of medications. People with RA who smoke have an increased risk of comorbid disease from pulmonary disease and osteoporosis, and premature death from heart disease. The combination of negative health effects associated with smoking in people with RA make a compelling case for smoking cessation. Smokers with RA may have specific medical and psychosocial issues that are not being met by generic smoking cessation programmes. However, there has been little research that has addressed RA-related barriers to smoking cessation and to date there has been only one arthritis smoking cessation intervention published. This suggests a gap in research and identifies the need for further research on smoking cessation in RA. The aim of this thesis was to identify barriers to smoking cessation in RA and develop an intervention to aid smokers with RA to overcome these barriers. By qualitatively investigating disease-related issues that make smoking cessation difficult for people with RA, five barriers to smoking cessation were identified: 1) people with RA felt isolated and unsupported when attempting smoking cessation; 2) people with RA were often unaware of the detrimental effects of smoking on RA and hence did not perceive this as a reason to quit; 3) smoking was used as a distraction from the pain associated with RA; 4) people with RA found it difficult to exercise and hence saw themselves as unable to use exercise as an alternative distraction from smoking, and 5) smoking was used as a coping mechanism for the frustrations of living with RA. A twelve week smoking cessation intervention, addressing these five barriers, was developed in association with Arthritis New Zealand and delivered by Arthritis Educators. The efficacy of the tailored intervention was assessed in a pilot randomised controlled trial. There was no significant difference in smoking abstinence rates at six months, although quit rates for both intervention (26%) and control groups (21%) were high compared to similar intensity smoking cessation programmes in the general population and the published arthritis smoking cessation study. The key support and advice from the Arthritis Educators were the most valued intervention components, followed by the specific smoking cessation components. There were common factors in the study that equally facilitated or impeded smoking cessation for all participants, including nicotine replacement therapy (NRT) as a shared treatment and the stress resulting from the Canterbury earthquakes. In addition, control group participants had independently developed their own strategies to control their smoking. The implications of this study are that although physical limitations and disease-associated factors adversely affect smoking cessation in RA, the lack of added benefit of a tailored smoking cessation intervention suggests a combination of brief advice and NRT is currently the best practice for supporting people with RA who wish to quit smoking. 2016-04-12T23:04:52Z Chemically induced DNA hemimethylation and active demethylation Magrath, Helena Eva http://hdl.handle.net/10523/6360 2016-04-07T23:40:08Z 2016-04-07T23:39:44Z Chemically induced DNA hemimethylation and active demethylation 2016 Magrath, Helena Eva The inheritance of epigenetic signals involves DNA methylation. DNA methylation patterns are inherited through cell generations by the action of DNA methyltransferases (DNMTs). During DNA replication DNMTs recognise hemimethylated DNA and, by the addition of methyl groups to the newly synthesised DNA, maintain methylation. However, the explanation of the cellular methylation machinery is far from completion and the current model of DNA methylation is controversial. Answering the question of how a cell maintains its individual methylation patterns is one of the central questions of epigenetics. The aim of this thesis was to attain deeper knowledge of the dynamics of DNA methylation by direct comparison of complementary DNA strands. I expanded the hairpin bisulfite sequencing method by several technical improvements to compare methylation symmetry of complementary strands of individual DNA molecules in synchronised, dividing Jurkat cells. The method was validated by numerous control and repeat experiments, and provided extensive methylation maps of several Jurkat gene promoters. Mammalian active DNA demethylation is a potentially important, but largely unexplored field. Genome-wide active DNA demethylation in cell lines has only been described in zygotes and embryonic stem cells, and a small number of studies have observed gene-specific demethylation which occurred as a response to physiological signals in somatic cells. I documented and visually mapped patterns of genome-wide active demethylation occurring in dividing Jurkat cell lines triggered by an oxidative treatment. Based on a mechanism proposed more than twenty years ago, most experiments employ Decitabine as a specific inhibitor of DNMT1. I observed actively demethylated strands in the heavily methylated Jurkat gene promoters PCDHGA12 and RASSF1 as early as 2 hours after Decitabine treatment; such demethylated strands were never observed in untreated cells. The observations of this study indicated that DNMT1 inhibition was not the only mechanism by which Decitabine affected DNA methylation and that research employment of Decitabine as a specific DNMT1 inhibitor should be critically reappraised. TET family proteins, which catalyse the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), have been associated with mammalian active demethylation. The involvement of TET enzymes was investigated by assessing promoter hydroxymethylation status during Decitabine induced active DNA demethylation using the exploratory method of hairpin oxidative-bisulfite sequencing. The results of this experiment indirectly demonstrated the involvement of TET proteins in active DNA demethylation. A surprising finding was that the oxidative compound glycine chloramine caused patterns of active demethylation similar to those observed after Decitabine treatment. The experiments documented active demethylation occurring in response to an environmental, oxidative trigger, which phenomenon has not been described before. The findings of this study point to an alternative model of DNA methylation dynamics. 2016-04-07T23:39:44Z Variability in neonatal gentamicin administration influencing drug delivery kinetics Lala, Anita Carol http://hdl.handle.net/10523/6353 2016-04-07T14:04:09Z 2016-04-07T03:48:30Z Variability in neonatal gentamicin administration influencing drug delivery kinetics 2016 Lala, Anita Carol Introduction: Intravenous gentamicin is frequently prescribed for the empiric treatment of early-onset sepsis in premature neonates1. The effective delivery of gentamicin may be influenced by infusion rate and flush volume2. Additional parameters affecting drug delivery kinetics may include route of administration, background infusion rate and drug measurement variability which we aimed to further quantify in this study. Methods: A self-administered questionnaire was completed by Dunedin hospital Neonatal Intensive Care Unit (NICU) nurses to investigate: the site of administration, comparing peripheral intravenous line (PIV) or umbilical venous catheter (UVC); and which would be used for a dose of gentamicin given two clinical scenarios describing babies of 24 and 32 weeks gestation. Secondary information was collected regarding flush volume. Intravenous infusions were then designed to simulate gentamicin delivery through UVCs with a constant background flow rate of 0.5 mL/hr. Intended doses of gentamicin (2 mg or 5 mg) in syringes were weighed before and after administration and given by bolus injection over 3-5 minutes followed by a flush of 0.9% saline (1 mL or 2 mL). Samples were collected at 5 minute intervals for 1 hour and analysed by high pressure liquid chromatography. Additionally, congo red dye (1% w/v) was used to mimic the drug administration phase during one replication of each dose/flush volume combination. Results: There were 42 nurses employed in Dunedin NICU during the survey period, of whom 37 (88%) responded. For a 24-week gestation baby, 34 nurses (92%) would administer into the primary lumen (20 ga), containing 10% dextrose (0.5 mL/hr), compared to 3 (8%) who would use the secondary lumen (23 ga), containing parenteral nutrition fluid (2.1 mL/hr). For a 32-week gestation baby 35 nurses (95%) would administer through the slow-flowing primary lumen. If a PIV was present this would be used preferentially by 35 nurses (95%) to reduce the risk of infection. Smaller flush volumes were documented following administration through the UVC compared with PIV (1.17-1.35 mL vs 2.4 mL at 24 weeks and 1.42-1.74 mL vs 3.2 mL at 32 weeks). Complete recovery of 2 mg and 5 mg intended gentamicin doses was observed following administration of both 1 mL and 2 mL flush volumes when administered via a UVC. Of the 2.15 mg administered dose recovered when a 1 mL flush is used, 85% (standard deviation, SD, 3.1%) was collected by 10 minutes and 93% (SD 1.4%) over the first 30 minutes. When a 2 mL flush was given, 99% (SD 0.5%) of the 1.88 mg administered dose was recovered in 10 minutes. Following a 5 mg intended dose, 93 % (SD 3.4%) was recovered at 10 minutes and 97% (SD 2%) in 30 minutes after a 1 mL flush, compared to 99% (SD 0.6%) recovered at 10 minutes with a 2 mL flush. Conclusion: Variability in neonatal gentamicin pharmacokinetics may be attributable to a number of factors. Clinical variability in the route of intravenous delivery was documented by means of a survey. Experimental evidence showed that simulated gentamicin delivery by bolus injection into slow-flowing neonatal central lines resulted in >90% dose recovery at 1 hour. Additionally, variation in the volumes of drug and flush prepared for administration, and retrograde flow of dye were observed. 2016-04-07T03:48:30Z Unlocking the PBFF. An evaluation of New Zealand's Population-Based Funding Formula Penno, Erin Christine http://hdl.handle.net/10523/6348 2016-04-06T21:34:08Z 2016-04-06T21:32:06Z Unlocking the PBFF. An evaluation of New Zealand's Population-Based Funding Formula 2016 Penno, Erin Christine New Zealand's District Health Boards (DHBs), which are responsible for delivering health services to their populations, receive their share of public funding according to the Population-Based Funding Formula (PBFF). The PBFF is intended to fairly distribute funding between DHBs according to the relative health needs of their populations and the costs of providing services to meet those needs. In 2014/15 the PBFF distributed $12 billion amongst DHBs, representing over two-thirds of the total health budget. Consequently, the PBFF exerts considerable influence on the health sector. Since its introduction in 2003, the PBFF has been subject to vigorous criticism. Significant differences in per capita funding, in conjunction with disparate financial circumstances, across the 20 DHBs has resulted in ongoing tensions within the health sector. Compounding uncertainty over the fairness of the allocation process, there is limited publicly available information regarding the methods underpinning the PBFF and little independent scrutiny of them. The aim of this thesis is to independently evaluate the PBFF, elucidating the current allocation methods and evaluating the capacity of the core determinant of PBFF allocations, known as the cost weights, to explain variations in need, use and expenditure. Four main studies – corresponding to chapters in the thesis – are undertaken to evaluate the PBFF. First, the methods underpinning the PBFF allocations are investigated and a methodological précis developed. Second, the PBFF is viewed from a comparative perspective and the main features of, as well as nuances behind, funding formulae across seven high-income countries, including New Zealand, are considered. Third, the relationships between health need, use and the PBFF cost weights are explored using data from the New Zealand Health Survey. Fourth, the predictive accuracy of the PBFF is evaluated at the individual and, crucially, the DHB-levels using routinely collected inpatient discharge data, as well as Census data, and compared against alternative models informed by richer demographic and clinical data. Overall, the results of these studies suggest that, despite its stated intentions, the PBFF does not support the fair allocation of health funding between DHBs. The vast majority of funding is allocated according to DHBs' population demographics. However, the agglomeration of the population into relatively few demographic clusters, in particular with respect to ethnicity, appears to obscure important differences in needs, use and expenditure between DHBs. Comparisons with international funding formulae underscore the relatively simplistic approach of relying exclusively on demographic data as a proxy for more fundamental drivers of demand for health care. Consistent with international evidence and practice, incorporating clinical data reflecting casemix or clinical complexity into the PBFF could considerably improve the predictive accuracy and equity of allocations between DHBs. These findings provide a cogent argument for revisiting the rationale and construction of the PBFF. Given the centrality of the PBFF to the New Zealand health system – which emphasises population-level health as well as the reduction of inequalities – there is a pressing need for transparent and inclusive discourse on the impacts of the PBFF, as well as alternative funding formulae, on different populations in New Zealand. 2016-04-06T21:32:06Z Transcriptional regulation of the Runx1 gene Marsman, Judith http://hdl.handle.net/10523/6329 2016-04-04T03:14:08Z 2016-04-04T03:13:43Z Transcriptional regulation of the Runx1 gene 2016 Marsman, Judith Runx1 is crucial for blood cell development and is one of the genes most frequently translocated or mutated in leukaemia, thereby contributing to disease pathogenesis. Runx1 is transcribed from two promoters, P1 and P2, and the resulting transcripts give rise to different protein isoforms. Runx1-P2 is required for the generation of definitive haematopoietic progenitor and stem cells, whereas Runx1-P1 plays a role in controlling their population size. The multisubunit protein complex cohesin is best known for its role in sister chromatid cohesion from G2 phase to mitosis. Cohesin also cooperates with the insulator protein CCCTC-binding factor (CTCF) to regulate expression of genes. Cohesin and CTCF spatially connect gene regulatory elements with promoters, thereby structuring the genome in three-dimensional space. Cohesin was previously shown to be essential for runx1 expression in haematopoietic progenitor cells in zebrafish. CTCF however, was not required for expression of runx1 during zebrafish development, but instead restricted its expression in multipotent cells of the tail bud. A large intronic region that harbours gene regulatory elements resides between the two promoters of Runx1 in all vertebrates characterized to date. In mouse, this region includes a haematopoietic-specific enhancer located 24 kilobase pair (kb) from the mouse Runx1-P1 transcriptional start site (TSS). In zebrafish, four regulatory elements located +13, +14, +39 and +89 kb downstream of the P1 TSS, were identified based on the binding of cohesin, CTCF or on the presence of enhancer histone modifications. However, their functionality in regulating runx1 expression was unknown. In my thesis, I investigated the mechanism by which cohesin regulates Runx1 expression. I hypothesised it does so by controlling the formation of chromatin interactions between regulatory elements and the Runx1 promoters. I found that cohesin controls isoform-specific expression of runx1 during zebrafish development, and that the regulation of Runx1 expression by cohesin is conserved in mammalian cells. Three of the regulatory elements identified in zebrafish, termed +13, +14 and +89, were capable of functioning as insulators in a CTCF-dependent manner, suggesting they may be involved in insulating regulatory activity within certain genomic regions surrounding runx1. Determining the function of the +39 element requires further investigation. I used circular chromosome conformation capture (4C) to identify novel regulatory elements that interact with the Runx1 promoters and the +24 enhancer in a mouse haematopoietic progenitor cell line, HPC7. 4C interaction data showed that Runx1 is located within a topologically associated domain in which not many other genes are present, indicating that regulatory elements located in this region are likely involved in regulating transcription from Runx1. The active promoter in the HPC7 cell line, P1, interacted with two conserved non-coding regulatory elements, as well as with the +24 enhancer. Each regulatory element recruits multiple blood transcription factors in HPC7 cells, suggesting they function as haematopoietic-specific enhancers. The inactive P2 promoter did not interact with any conserved non-coding elements. Cohesin and CTCF did not bind to the putative enhancer elements, and do not seem to be directly involved in the formation of their interaction with Runx1-P1. Instead, cohesin and CTCF might organise the chromatin domain in which Runx1 resides, which in turn controls the availability of regulatory elements to interact with Runx1. Overall, the findings of my study suggest that spatial and temporal regulation of Runx1 gene expression could be orchestrated by cohesin, through its role in organising chromatin in three-dimensional space. 2016-04-04T03:13:43Z Investigations of Heterogeneity, Directionality, and Involvement of Associative Memory in Synaesthesia Goei, Jesicka Andianti http://hdl.handle.net/10523/6323 2016-04-03T23:36:09Z 2016-04-03T23:36:00Z Investigations of Heterogeneity, Directionality, and Involvement of Associative Memory in Synaesthesia 2016 Goei, Jesicka Andianti Abstract The perceptual phenomenon of synaesthesia involves perception of additional, unrelated sensory experience (concurrent) when a stimulus is perceived (inducer). For grapheme-colour synaesthetes, perceptions of letters, numbers, and/or shapes (inducers) automatically produce perceptions of synaesthetic colour (concurrents) specific to each grapheme. Typically synaesthetes experience unidirectional forward synaesthesia where only perceptions of inducers produce perceptions of concurrents. However some synaesthetes also experience implicit reverse synaesthesia where presentations of synaesthetic colours bias their responses towards the associated graphemes without conscious perception of said graphemes. In very rare cases, synaesthetes experience explicit reverse synaesthesia where synaesthetic colours produce perceptions of associated graphemes. The current thesis explores the heterogeneity of bidirectional synaesthesia and involvement of associative memory in it. In Chapter 2, the hypothesis that synaesthetic experiences were heterogeneous but consistent and automatic was supported. Consistency of synaesthetes' grapheme-colour pairings was calculated and compared to those reported by 10 respective controls in colour-matching tasks. Synaesthetes consistently matched graphemes to their synaesthetic colours while controls did not. Synaesthete S1 and S2's automatic synaesthetic experiences were confirmed using synaesthetic Stroop paradigms, where they identified font colours of presented graphemes (Stroop1) and synaesthetic colours experienced (Stroop2). Synaesthetes identified relevant colours faster when graphemes were presented in their synaesthetic colour compared to when graphemes were presented in another grapheme's synaesthetic colour. In Chapter 3 synaesthetes S1, S2, and their control named colours experienced or associated in response to visual and auditory graphemes presented in a 1.5T magnetic resonance imaging (MRI) scanner. It was hypothesised that neural correlate similarities accompanied behavioural similarities shown in Chapter 2. Post-hoc region of interest analyses supported the hypothesis as the right inferior frontal gyrus (RIFG) was commonly activated in synaesthetes only. S3 reported that he experiences the very rare explicit reverse synaesthesia. Neural correlates which underlie his explicit reverse synaesthesia were hypothesised to be different from those of the forward synaesthesia (Chapter 4). When presented with his inducers, S3's RIFG was activated; however when presented with his synaesthetic colours results indicated left IFG activation. Different IFG involvements in forward and reverse synaesthesia suggested that S3's explicit reverse synaesthesia might be a learnt phenomenon, involving higher processes such as associative memory retrieval. This was supported by behavioural results as S3 performed faster than trained controls when matching colours to graphemes (forward-matching paradigm) and vice-versa (reverse-matching paradigm), but was slower in the reverse-matching paradigm compared to the forward paradigm. Chapter 5 investigated further the involvement of associative memory in synaesthesia. Trained controls and synaesthetes with implicit reverse synaesthesia (S4, S5, and S6) responded to target stimuli in forward and backward associative-priming paradigms following letter and colour-patch primes presentations. It was hypothesised that synaesthetes would outperform controls indicating enhanced associative memory access is involved in a bidirectional manner. Synaesthetes were faster than controls when they accessed forward letter-colour pairings. When synaesthetes had to retrieve reverse colour-letter associations, varying levels of facilitation were shown. This indicated that a spectrum exists based on the degree synaesthetes use associative memory to access bidirectional grapheme-colour associations. Taken together this thesis indicates that heterogeneity in bidirectional synaesthesia also exists due to the varying degrees of bidirectional inducer-concurrent access through associative memory retrieval. The findings provide further evidence that learning and memory play a role in synaesthesia. 2016-04-03T23:36:00Z


text:
Expectations for Rose at the Zurich Classic
Ryan Burr, Brandel Chamblee and David Duval examine Justin Rose's chances for defending at the 2016 Zurich Classic. Watch Golf Central on Golf Channel.
Rose going week on-week off during busy season
Justin Rose explains the adjustments he is making to compensate for the busy golf season. Watch Morning Drive on Golf Channel.
Rose thrilled to represent Great Britain in Olympics
Justin Rose is excited to play in the Rio 2016 Olympics. Watch Morning Drive on Golf Channel.
Rose on working with R&D at TaylorMade
Justin Rose explains how he gives feedback to TaylorMade to help with the design of the clubs in his bag. Watch Morning Drive on Golf Channel.
Rose, Kaufman among MCs at weather-delayed Zurich
After a long delay Thursday and a marathon Friday, the 36-hole cut was finally made late Saturday morning.
R&R a must for Tour players
As in down time. With the pressure of modern PGA Tour life, it's a must - whether that's family time or party time.
Swing of things: How Rose can help you
Justin Rose shows off his swing on the range at TPC Louisiana. Watch Morning Drive on Golf Channel.in the zone? Athletes, they talk about it, Michael Jordan, other sports, Tom Brady , Phil Simms going 21 or 22. I mean, do you believe that, that translate to golf as well? Are there rounds where you feel like you're just kind of in your own world? Yeah 100 percent I think that's what we strive for. And it doesn't happen very often but when it does it's kind of like that nice magical place but I really work hard. And the last couple of seasons I tried to make the shift from being very technical and trying to hit the positions and the golf swing to now seeing the golf shot looking at the fade, feeling the fade connecting myself to that fade. And then trusting that
Rose: Taking Augusta putting change to Zurich
2015 Zurich Classic champion Justin Rose explains the state of his game as he gets ready to defend his title. Watch Morning Drive on Golf Channel.Absolutely helps Thank you very much We'll be joined now by Justin Rose the 2013 United States Open Champion. And as you mentioned, defender here at the Zurich Classic of New Orleans. Justin, good morning, how are you? Good, how are you Bob? I'm doing just fine. Excellent. You've got four top tens this year. A tie for tenth at the Masters. Give us the state of Justin Rose's game on April 27th 2016 Yeah, I think, everything is running smoothly. The vehicle's in good shape. Everything's nicely serviced if you
Fantasy: A Rose repeat down in the Big Easy?
GolfChannel.com fantasy guru Will Gray breaks down the players to consider for the 2016 Zurich Classic. Play alongside our experts by logging onto www.golfchannel.com/fantasyto walk you through the Zurich Classic of New Orleans as the PGA tour heads down to the Big Easy. Let's start with group one it's a small but action packed group. Only three players tough choice. I'm leaving Ricky Fowler in third but I'm honestly really torn between Justin Rose and Jason Day. Both guys have been playing well basically since Tory Pines rose four straight top fifteen finishes here. Played 66
Masters win moves Willett to ninth in the world
Thanks to his dramatic, come-from-behind Masters victory on Sunday, Danny Willett has advanced to ninth in the Official World Golf Ranking, a career-high for the 28-year-old.
Masters Tracker: Day 4 at Augusta National
Danny Willett has won the Masters after shooting 67 and an epic collapse by Jordan Spieth.
Breed: Rose must improve putting to win Masters
Michael Breed and Kelly Tilghman examine why Justin Rose has yet to win the Masters. Watch Live From the Masters on Golf Channel.Michael, Justin Rose has established himself many times at Augusta National , but he's never closed the deal. Three times he's been the leader after round one, but as you heard him say at
Major champ Rose likes flying under the radar
Justin Rose addresses the press at Augusta National Golf Club prior to the Masters. Watch Live From the Masters on Golf Channel.Justin Rose met with the media. Here's what he had to say. I mean it always feels good to be back here and I mean 11 times I guess is an honor I suppose. That's getting up there now and I'm getting to the point where I can't remember if it's 10 or 11 so I think that's a good thing. Obviously plenty of knowledge of the golf course . Plenty of respect for the golf course . I don't think you ever Feel like you've necessarily mastered it because invariably you learn something new every year which is whata lifetime experience and opportunity. And Should my career look something like, Justin Rose , multiple Major champion, and a gold medalist, I think that that's how it's going to read. I think that it's going to
Gallagher: Ball-striking, patience keys for wind
Jim Gallagher, Jr. thinks Justin Rose and Louis Oosthuizen are the favorites to win if the wind blows at the 2016 Masters.Who is Jim Gallagher Jr. who's competed in the Master's tournament five times in his career. Actually held the lead in his very first round as a rookie Master's participant. So a little feather in your cap. I want to go back to your early week predictions of Justin Rose and Louis Oustheizen as men who you believe could walk away with the green jacket this year. Interesting to note that even