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Best Buy Gets Oculus VR
Best Buy will sell the Oculus Rift virtual-reality headsets at some of its retail stores starting Saturday.
Tech Company Settles Transgender Discrimination Complaint
The U.S. Equal Employment Opportunity Commission says a technology services company working in Minnesota has agreed to pay $140,000 to settle a transgender discrimination complaint.
Dish Techs Now to Fix iPhones
When Dish technicians aren't busy installing satellite TV services in people's homes, they'll be making house calls to replace iPhone batteries and broken screens.
3 Planets Orbiting Dwarf Star Prime Spots to Search for Life
Astronomers searching for extraterrestrial life may need to look no farther than a small, nearby star.
No-Selfie Zone: Not OK in Voting Booth, West Virginia Says
If you want to share your voting experience on social media, you'll have to find some way other than taking a photo in the voting booth. West Virginia Secretary of State Natalie E. Tennant says it's forbidden.


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Results 6 to 10 of 28
November 12th, 2013 06:00 PM #6
Bluebell is very sweet and beautiful. Personally I would use Bluebell as a middle name. You could always call her by her middle name but she could have a first name on her birth certificate that could grow better on her.
Anna Bluebell
Livia Bluebell
Grace Bluebell
Noelle Bluebell
Nora Bluebell
Mary Bluebell
Willa Bluebell
Stella Bluebell
Sadie Bluebell
Eva Bluebell
Eve Bluebell
Noa Bluebell
Eleanor Bluebell
Emma BluebellHenry Oliver Birch | Jack Rowan August | George Emory Tobias
Sophie Elizabeth Fable | Emma Jane Magnolia | Lily Anne Vesper
Piers Lachlan Wilder | Teddy Dashiell Fox | Miles Archer Boone
Grace Margaret Birdie | Nora Isobel Sunday | Evelyn Claire Worley
_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
❤ heart my son ❤
November 12th, 2013 08:20 PM #8
November 12th, 2013 08:26 PM #10
I love Bluebell. It use to hold a spot in my top 5. I love the PP suggestion of Bluebell Lorraine. Some suggestions I like personally, but of course this isn't my child, are:
Bluebell Beatrice/Beatrix
Bluebell Lenore/Lenora/Leonora
Bluebell Eliza
Bluebell Harriet
Bluebell Christine
Bluebell Amelia
Bluebell Caroline
Bluebell Ophelia
Bluebell Odette
Bluebell VictoriaMommy of Juniper Teagan & Pyrus Nikolai
Expecting a little Catkin or
Fox June 2016
Pennyroyal, Nettle, Dandelion, Kitsune, Snapdragon, Henley, Perdita, Roisin, Honeysuckle, Fianna, Henbit, Chihiro, Rhoswen, Zerlin, Anonna, Araluen, Celandine, Madelief, Fionnuala, Fflur, Amabel, Olwen, Galatea
Huckleberry, Senna, Bramble, Thistle, Aryeh, Wolf, Sol, Guthrie, Thackeray, Atticus, Angus, Cormac, Jules, Bear, Yancey, Itsuki, Larkspur, Blue, Robin, Ewan, Cornelius, Clove, Phelan
November 12th, 2013 08:43 PM #12
November 12th, 2013 08:46 PM #14
My first thought was Bluebell Charlotte...and since I just read that someone else suggested it, I am sticking with it! lol
I can TOTALLY see Bluebell on a grown woman...and if she grows up and totally hates it, she could go with the very common, normal Bella or Belle as a nickname. Nothing wrong with that. If my name was Bluebell though, I would just love it!
Bluebell Elizabeth
Bluebell Caroline
Bluebell Charlotte
Bluebell Sienna
Bluebell Maria----------------------------------------------------------------------------------------------------------------------------------
Shae - Mallory - Margaret - Dorothy - Mary - Penelope - Luca - Veda
Huckleberry - Colt - Benno - Fielder - Boden - Kick - Shannon - Harvey

subset: commoncrawl


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Orville Don Hasler, 93, of Bloomfield, passed away at 12:15 a.m. on Friday, April 15, 2011 at Glenburn Home.
He was born on Jan. 23, 1918, and was the son of Orville and Khiva (Ockerman) Hasler. He was married to Irene (Martin) Hasler for 66 years.
He was a World War II veteran, who served in the South Pacific, and was a mechanic on B-29 airplanes. He went on Hoosier Honor Flight II for WW II veterans on April 22, 2009 to Washington DC. Upon his return to Bloomfield in 1946, he was Service Department Manager at Wilson Chevrolet, Inc. In 1956, he bought his first service station on West Main Street. In 1957, a new Gulf station was built on South Washington Street that he managed. Hasler Oil Company was incorporated in 1974. He also was a 60 year member of the American Legion Post 196 of Bloomfield and was a charter member of the Bloomfield Lions Club.
Survivors include: two daughters, Brenda (Jim) Hughes of Sandborn and Sherry (Bill) Hixon of Bloomfield; one son, Gary (Debbie) of Bloomfield; seven grandchildren, Natalie Davidson of Eden Prairie, MN, Brad Hughes, Valerie Lifford, and Megan Nonte of Bloomfield, Kara Bowling of Loogootee, Angie Smith of Jasper, and Troy Hasler of Clearwater, FL; 16 great-grandchildren; brother-in-law, Curt Bucher; several nieces and nephews and several great-nieces and nephews.
He was preceded in death by his wife, Irene on April 23, 2005, parents, sisters, Betty Heaton and Doris Bucher; brothers, Roy Hasler, Dean Hasler and Ted Hasler and a great-granddaughter, Kylie Hasler.
Funeral service will be conducted 11 a.m. Tuesday, April 19, at Jenkins & Sons Funeral Home in Bloomfield, with Rev. Arlen Pope, Rev. Rose Sparks and George Ockerman officiating.
Interment will follow in Walnut Grove Cemetery.
Friends may call from 4 to 8 p.m. Monday and from 9 a.m. until the hour of service Tuesday at the funeral home.
The family asks that all memorial contributions be made to Walnut Grove Cemetery.
Online condolences to the family are available at www.jenkinsfuneralhomes.com.


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Tuesday, July 24, 2012
125 Comments | Copyright: India-Forums.com / TellyBuzz
Colors TV ongoing celebrity dance reality show Jhalak Dikhhla Jaa 5 - Dancing with the stars is trying to bring out something new every week. Tellybuzz earlier reported that this season of Jhalak will be introducing six new dancing stars to the stage of Jhalak, who will be entering the show through wild card entry. The 5 names as Karan Wahi, Rithvik Dhanjani, Jay Soni, Avika Gor and Rashmi Desai Sandhu have been already revealed who will be seen making their entry to the show as wild card entrants.
Curtain was down on the name of the 6th wild card entrant on the show but now the name of the 6th contestant has been revealed who is going to be Neha Bhasin.
Neha Bhasin, who is best known for her singing, is also a songwriter, performer and a TV hostess. Recently, the song Dhunki from the movie Mere Brother Ki Dulhan sung by her was a big hit. Now Neha will be seen giving a tough fight to all other contestants by burning the dance floor of Jhalak with her amazing performance in the wild card entry.
We get to know that only two contestants will be
making their entry as the wildcard entrants.
Reporter: Ranjini Nair
Author: Anwesha Kamal
Veteran actress Rita Bhaduri to enter Mrs. Kaushik Ki Paanch ...
Celebs on: If given 1 lakh rupees, then how will they spent it.
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Siddharth Nigam debuts in King's Entertainment's film "Tez Raftaar"!
Bigger and better..!
Actress Sonam Kapoor wished her fellow L'Oréal Paris brand ambassador ...
Actress Katrina Kaif says "Baar Baar Dekho" is one of the "nicest ...
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Matric SSC & Inter HSC Part 1, 2 Result 2016 BSEK & BISE - Find all online results of BIEK Intermediate HSC & BSEK Matric SSC board of Pakistan including Karachi, Lahore, Federal and other educational board. There results usually came out in between months of June to September in all Pakistani Educational Board. The academic results are Inter HSC part 1 pre engineering, HSC part 1 Pre Medical, HSC part 1 commerce, Humanities, Home Economics and General Science. Similarly Matric SSC Part 1 Result 2016 of Science and General regular and private groups. Get all the 9th & 10th, 11th & 12th class result 2016 online of Karachi, Lahore and other board as they available.
Are you a student and looking up for some reliable online source for checking result updates? HamariWeb brings you latest updates and results online for SSC & HSC part 1 & 2 2016 students of all disciplines. You can check out our exclusive Matric SSC part 1 & 2 pages online and catch the latest updates of board. The students of Karachi, Lahore, and Peshawar can check their respective results for SSC part 1, SSC part 2, HSC part 1, HSC part 2 results online by simply providing your roll number, and selecting your relevant examination category. You can access to your results within seconds.
Find Inter HSC part 1 & 2 Home Economics & Medical Technology HSC Results 2016 Karachi, BISE Lahore, Faisalabad, Rawalpindi Board Multan, Sargodha, Gujranwala, Sahiwal, Bahawalpur & Faisalabad online result both regular and private group. Get your 9th, 10th, 11th, 12th class result now under All Pakistan Boards of Intermediate Result & Secondary Education and all other academic results of Pakistan. Find latest online academic of all Pakistan education boards. Find Matric (9th, 10th) Inter (part I and II) BA, BSc, B.Com, MA, MSc, M.Com and all latest online.
DAE 2nd Year Result 2016 SBTE 2016 Online
sir result kab aye ga 2nd year ka
B.Com Part 1 Result 2016 Karachi University UOK - Regular & Private
b.com part-1 ka result kab aye ga tell me
BA Part 1 Result 2016 Karachi University UOK - Regular & Private
Has Ba part 1 result out ???
HSC Part 2 Pre Engineering Results BIEK Karachi 2016 Online
My percentage in part 1 of Pre Engineering was really good! I am all ready to maintain it or improve it in further in HSC Part 2 Pre Engineering Results. Insha Allah
HSC Part 1 Result 2016 Pre Engineering - BIEK Karachi Inter Board
First year HSC Part 1 Result 2016 of Pre Engineering group will be available online here. My preparations are good and I hope to secure an A -1 grade and good percentage.
HSC Part 2 Pre Medical Results BIEK Karachi 2016 Online
I hope to get a better percentage in my HSC part 2 Pre Medical exams of Karachi board. Only if I get better percentage, I will be able to get admission in medical college.
HSC Part 2 Commerce Results BIEK Karachi 2016 Online
I got good percentage in my Inter part 1 exams but I am all worried about my part 2 exams of commerce group. I am prepared but fear of losing my percentage. Pray for me please
HSC Part 1 Result 2016 Commerce - BIEK Karachi Inter Board
I have prepared well for my BIEK HSC part 1 commerce exams and wish to see my name among the toppers Insha Allah! Will check my results online here.
Bise Gujranwala 10th Class Results 2016 Online
I have given the papers of BISE Gujranwala 10th class and expecting result to be published pretty soon. The arrangement of the papers was not up to the mark and I am not satisfied from the system.
Bisegrw.com 9th Class Result 2016 Gujranwala Board Online
Can we get our results online on www.bisegrw.com for 9th Class? I am not going to check it in front of my school mates, I am scared from my Chemistry paper result


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Reviews by rickyeatos
Best game i ever play in a long timerickyeatos | Sept. 8, 2015 | Review of Life is Strange Complete Season Episodes 15 - PC
I love to play games like this one, i bought it with full price the complete season and i can say this is one of the games which is worth every cent spend, don't wait until deals and buy it now, Square Enix really did a great job with this game and i also can say this game alone can Knock out all the games from telltale games (if you like them, you will like this one), the graphics and atmosphere are fantastic, the soundtrack of the game is touching, the gameplay is enjoyable with various puzzles and you can take pictures in-game to earn the collectables achievements. And a history which will trap you for a long time. the only thing bad in the game is the voice of the characters, almost everyone are annoying.
Excelent game, but watch the show firstrickyeatos | Sept. 8, 2015 | Review of Game of Thrones A Telltale Games Series - PC
This game really surprise me, i never watched the game of thrones but has a fan of telltale games, i give this game a try and it was really worth it, bad thing was i didn't understand why everything was so broken at the first episode. the graphics are really good in my opinion and also the voices of the characters. some from the original show it's something very epic when you can interact with them This is a very enjoyable game, even if you don't see the show. but i'll recommend you do it before playing. it will have more emotion
Addictive. you will lose your sense of timerickyeatos | June 10, 2014 | Review of Super Sanctum TD - PC
I grab this game from the super sanctum TD promo and i decide to give him a chance to see how the game is. when i finish playing him i realize it was like 5 hours later (and my plan was just testing him for 10 minutes). if you want to play this game. don't do it unless you have some kind of alarm or a total free week of everything. you will lose all the sense of time when you play this. just you... one map full of empty spaces when you must place a different selection of towers to defend your sentry core from and whole army of bad guys that will spawn by waves. you will earn credits to buy more towers and you must place them in strategic places to try block the enemy's advance and in case of emergency you also can drop to the enemy's a different selection of special powers like a explosion or just teleport them a few steps back to make some time. very addictive, very good game and for very cheap
what the goats did i just play?rickyeatos | May 6, 2014 | Review of Goat Simulator - PC
ok... you are a goat and you can destroy everything with just your presence. the game is also full of bugs everywhere which can make you even mad or laugh very hard mostly when our goat starts to make a weird buggy break dance. the game is really bad... very funny in the first hours but after that, he really stars to be a little borring
One of a kindrickyeatos | May 6, 2014 | Review of Final Fantasy VIII - PC
The game still have that magic to keep the fan happy, a complete rpg mode with magic junctions in the basic stats of every characters can mean the different between win or die. you can earn this magic by drawing them from your enemy's, extraction points and with skills of your G.F. the game have a classic battle in turns system but the kind of skills and things you can make to hurt your enemy's is very unique, the GF can help you a lot not just for they devastating attacks but by they skills which can grant your characters with special commands in battle like health the status of a poisoned team mate or steal a item from your enemy's or even better they can make you more strong by adding a 30% of a stat or grant you with auto-haste to be more fast than your enemy's the graphics even when the game is really old. it's not a problem for ff VIII because he has one of the best graphics of the play station 1 and with the most epic intros and cut scenes you can ever see in others play stations 1 titles. (in my opinion this game is a complete play station 2 title) the music, even when i see a lot of bad reviews for this game on steam exactly for the music, this can't stop you to still have a lot of fun with this game. or at least i didn't even notice the music is a bit different from the original. Best game play, all a world to explore and secrets to discover. The mini game most addictive is the cards game when you can find a card of all the monsters in the game, GF, bosses and of course the cards of your characters and finally, the best story ever made for a game of the play station 1. this game is one of a kind in the ff titles. no matter in what console or pc you play it. you will enjoy it.


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Parenting by TheSodaSmugglerWatch
©2012-2016 TheSodaSmuggler
lineart request for ElementsOfNature! free usage just give me credit and a link back,I want to see the finished work!
Used!! .3.
I have a request by any chance could you do one of a mother standing over her pup to protect her from attackers?
Thanks for these wolf bases. They are really useful for my story.
I have a request can you draw a lineart of a mother wolf protecting her five pups?
God work ^^
I was going to ask if I may use this?.. Then again I see it's a special request so I don't know if you might let me.
~ This is one of the best bases I had ever seen with a wolf and a pup.
~ This is one of the best bases I had ever seen with a wolf and a pup.
Very nice, you seem to be taking an awful lot of requests too. DA needs more decent MS Paint lineart.


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STARmeterSEE RANK
Down 45,849 this week
Guy Fauchon
Guy Fauchon was born on December 1, 1965 in Swift Current, Saskatchewan, Canada. He is known for his work on Final Destination (2000), License to Wed (2007) and Holiday Heart (2000). See full bio »
Born:in Swift Current, Saskatchewan, Canada
More at IMDbPro » Represent Guy Fauchon? Add or change photos
1 video »


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- Ampio's management and resources will be totally focused on advancing our lead therapeutic compounds, Ampion™ and Optina™ through pivotal clinical trials in the United States and securing commercialization partners world-wide for the Zertane™ sexual dysfunction drug portfolio.
- A key Ampio asset, the ORP Platform, will be commercialized more rapidly to become a provider of world-class diagnostic testing systems while retaining a majority ownership of Luoxis for our existing Ampio shareholders."
Ampio Forms Luoxis Diagnostics To Commercialize ORP Technology
GREENWOOD VILLAGE, Colo., Feb. 11, 2013 /PRNewswire/ -- Ampio Pharmaceuticals, Inc. (Nasdaq: AMPE), a biopharmaceutical company focused on developing drugs to treat prevalent inflammatory diseases, such as osteoarthritis (OA) and diabetic macular edema (DME), announced the incorporation and initiation of operations of Luoxis Diagnostics, a subsidiary of Ampio that will initially be funded through a private placement, with Ampio maintaining approximately 80% ownership post financing. Josh Disbrow, Ampio's Chief Operating Officer, will assume the role of Chief Executive Officer of Luoxis. Details about the private placement will follow in the near future. (Logo: http://photos.prnewswire.com/prnh/20120516/MM09116LOGO)Ampio Chairman and Chief Executive Officer, Michael Macaluso, noted "The Oxidation Reduction Potential (ORP) diagnostic device and its patent portfolio has been "carved out" to become the lead asset of Luoxis Diagnostics, an in-vitro diagnostics company focused on the development and commercialization of diagnostics utilizing the company's ORP technology platform to indicate disease severity and progression across a wide range of critical and chronic illnesses. The ORP platform is a valuable asset in which the development of the "point-of-care" reader and disposable testing strips have been completed and multiple clinical trials with stored blood samples from patients with various diseases are underway. Luoxis now needs its own management and financing to launch a comprehensive effort to assure the success of its commercial launch." Mr. Disbrow, Luoxis's CEO, further explained the strategy "Ampio is a pharmaceutical company mainly focused on treatments for inflammatory diseases. Now, by carving out the diagnostics program and arming it with dedicated management and funding we are accomplishing two main goals that will benefit AMPIO shareholders:
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Current Exhibition:
Philip Trager: Photographing InaFriday March 25, 2016 - Sunday May 22, 2016
Following a retrospective exhibition in 2006 of his internationally renowned images of architecture and of contemporary dancers, Philip Trager responded to the opportunities presented by digital photography and created a new series of images. This has culminated in the book Photographing Ina, forthcoming from Steidl in May 2016. The exhibition, like the book, has two parts. The first is a series of immaculately composed black-and-white photographs taken in the 1980s, after 25 years of marriage. The second part, taken in the last decade after 50 years of marriage, reveals Trager's new color photography—an unexpected and tender meditation on the act of photographing, on perception, color, and light.


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Minimizing Triggers
Determining what your asthma triggers are is the first step in controlling your asthma symptoms. Some of the top asthma triggers include stress, allergies, cold air, and exercise.
Latest posts
Most Popular
Minimizing TriggersAsthma in the City
What is Asthma?9 Interesting Allergy and Asthma Facts
What is Asthma?10 Tips for People Just Diagnosed with Asthma


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WESTPORT Basic Plus Size Black Bootcut Jeans, Short
$32.50 $9.75
Sale $9.75
Rated 3.9 out of 5 by 37 reviewers.
Rated 4 out of 5 by mac63 easy to wear these jeans were soothingly comfortable but i washed them after i tried them on because of the instructions about the dye and they became a little stiff but i am intending to wear them and "break them in". the color seems like a cheap black shade but that doesn't irritate me. i bought them in short even though i am 5 ft 7 because i don't want to have to cuff or tailor them and the length they are is ideal. i call the size large because normally i am a size 22 or 2x and i bought these in a 20 because of the spandex. March 25, 2016
Rated 4 out of 5 by in2disney2 Comfortable and size true. I've purchased these jeans 3 times but be warned - they are listed as "short" but they are still almost 3" too long for me (not everyone wears 3" heels with jeans!). Since it's difficult to find plus size boot cut in short or petite anymore, these are the best choice right now. They also fade out a little faster than I would like. March 3, 2016
Rated 4 out of 5 by BeautynSimplicity Yay! Not 'Mom" jeans These jeans feel soft, have a little give, & the waist is right on top of the hips so the fit feels comfortably snug so they don't stretch so much (w/the spandex) that they fall down by the end of the day. They are sold as "short" & that works for my petite stature. However they still are about 2 inches too long so I will have to have them hemmed. That's unfortunate because in other store brands like Old Navy, LB, & others, "short" fits in length & I never have to hem them. That's the only reason I gave them 4 stars. Otherwise, I really like the style & how they feel/fit. February 5, 2016
Rated 5 out of 5 by lady5 wash then wear and look great I washed them before wearing and they were great. fit is perfect. will be ordering another pair in different color. January 23, 2016


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I have a model with a Boolean checkbox, and when it is clicked 'true' I would like to display the image, and if not clicked 'null' would like to display absolutely nothing.
So far the view is called as:
<%= image_tag(@dining.pets? ? 'petfriendly.png' : '', :title => 'Pet Friendly', :alt => 'Pet Friendly') %>
The empty tick '' was my attempt at nothing, but it just gives me a broken link image. As this is my personal attempt at working this out and I'm relatively new to rails, I am not sure if an if/else in long form is a good way to go about this?
Any ideas? Thanks!


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128 Miles
207 Km
2 hours 7 mins
77 Miles
124 Km
39 mins
5.93 Gallons
Fuel Needs
0.91 Pounds CO2 fp per miles
Distance from Watsonville, CA to Stockton, CA is 128Miles or 207 Km. You can get this distance about 2 hours 7 mins. If you want to planning travel with plane, you can get this distance about 39 mins .
A car with an average MPG will needs 5.93 gallons of gas to get the route between these points.
The estimated cost of gas to get between Watsonville, CA and Stockton, CA is $13.46.
During the route, an average car will release 116.18 pounds of CO2 to the atmosphere. Your carbon footprint is 0.91 pounds of CO2 per mile.
* Average US MPG used for calculations is 21.6 MPG.
* Average US gas price used for calculation is 2.27 per gallon.
* Coordinates of Watsonville, CA is 36.9102477, -121.7568805 and coordinates of Stockton, CA is 37.9576532, -121.2907655
All Rights Reserved. © 2010 - 2016 About Feedback


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Grapplers take tough loss from Tigers
February 18, 2016 Photos by Mike Audi The Poland Bulldogs hosted Howland High School for senior night Feb. 11 at the Poland Fieldhouse. more »»
Bulldogs regain battle crown
February 18, 2016 The Poland varsity Bulldogs hosted the Canfield Cardinals Friday at the Poland Fieldhouse for the Battle of 224 basketball game. more »»
Four grapplers place at Hephner
January 28, 2016 The Poland Seminary High School varsity wrestling team competed Friday and Saturday at the Josh Hephner Memorial Tournament at Austintown Fitch High School. more »»
Freshman Bulldogs caged by Spartans, 45-42
January 28, 2016 Photos by Jim McCreary, Town Crier... more »»
Freshman girls fall to Spartans
January 28, 2016 Photos by Jim McCreary, Town Crier ... more »»
Eighth-graders stomp AMS Red, 51-13
January 28, 2016 Photos by Mike Audi, Town Crier... more »»
Grappplers compete at Top Gun
January 21, 2016 The Poland Seminary High School wrestling team traveled to Alliance High School Friday and Saturday to compete at the two-day Top Gun Tournament, which featured 46 teams from across Ohio and West... more »»
Grisdale captures 400th career victory
January 21, 2016 For the past 23 years, the one constant at Poland Seminary High School has been boys head basketball coach Ken Grisdale. Over that span, Grisdale's clubs have won nine district championships. more »»
Bulldogs tame Red Dragons, 67-17
December 3, 2015 Photos by Mike Audi, Town Crier... more »»
Bulldogs prep for season
November 25, 2015 Photos by Mike Audi, Town Crier ... more »»
Poland drives by Jefferson in rain
September 17, 2015 Poland traveled Friday to Jefferson Area High School to battle the Fighting Falcons, both with a 2-0 record. Minutes before the 7 p.m. more »»
Poland girls put up fight, lose to Cards, 3-1
September 17, 2015 Photos by Mike Audi, Town Crier... more »»
Poland's running game wins season opener
September 3, 2015 The Poland Bulldogs faced off against the Marlington Dukes during the Aug. 27 season opener at Dave Pavlansky Field for the seventh year in a row with the series tied, 3-3. more »»
Dogs scrimmage for United Way
August 27, 2015 The Poland varsity football team hosted the Girard Indians Aug. more »»
OHSAA approves new divisional realignment
August 27, 2015 The Ohio High School Athletic Association board of directors approved Aug. 13 new divisional assignments for some state schools. This realignment was based on updated school enrollment figure. more »»
Poland getting primed for playoff season
August 20, 2015 It is no secret that one of the two best football teams in the All-American Conference White Division heading into 2015 is the Bulldogs. more »»
Boys, girls finish strong at invitational
April 30, 2015 The Bulldogs boys and girls track teams hosted the 20th annual Poland Invitational track meet Saturday at Poland Seminary High School Stadium with more than 50 teams competing in one of the state's... more »»
Freshman Dogs take close win over Spartans
January 22, 2015 Poland freshman girls vs. more »»
Poland places two grapplers at Top Gun Tourney
January 22, 2015 Poland traveled a short distance to Alliance for the 29th annual Top Gun Wrestling Tournament last Friday and Saturday. more »»
Bulldogs overpower the Spartans, 58-37
January 16, 2015 Bulldogs overpower the Spartans, 58-37... more »»
T.O.P.S. Group 2191 weekly meeting April 28, 2016
T.O.P.S. Group 2191, Austintown, meets at 6 p.m. Thursdays at Wickliffe Presbyterian Church, 45 Idlewood Drive, Austintown. TOPS (Take Off Pounds Sensibly) is a support group for those trying to lose weight. For more information, call 330-799-2894, or visit www.tops.org. more »
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Eating to Live!
May 30, 2013 Thanks to social networking websites, such as Facebook and Pinterest, it's easy to find quick and easy recipes to help get through a busy week, but is it really healthy? One thing I've noticed... more »
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"A surging chaotic power"
"International cybercrime treaty advances slowly"
"The tyranny of code"
Government has many vital roles, including ensuring stability, peace, equity
and justice. In every country, a relationship of trust, accountability and
predictability between the public and private sectors is essential. Today's
global information society increases the potential and importance of such
Government's most important role in an information society is to create
an environment that encourages private-sector action, while protecting consumers
and citizens. The second essential activity is to transform government operations
using the power of information technology to decrease costs and improve
As the Organization for Economic Cooperation and Development notes,
"By making governments more accessible and more accountable, e-government
can help to improve citizens' trust in those that govern them."
Understanding of these notions is spreading. One innovative example
discussed in a recent survey of 53 emerging economies conducted by McConnell
International LLC comes from Estonia, which pioneered a network-based document
system in August 2000. After a decision that all cabinet meetings would
be conducted online as well as in person, senior government officials were
provided with laptops to prepare digital materials for the paperless meetings.
Under this system, agendas are updated during meetings, documents are
linked to further sources of information and ministers can consult with
other ministry officials, all via the Internet. Efforts such as these familiarize
government officials with the advantages of IT. Without a hands-on approach
to IT at senior levels of government, policy-makers will neither understand
what the technology can do nor appreciate the kind of light-handed regulation
that its volatility demands.
Government action to create an information society is often aided by
the collaborative efforts of public/private committees. In some cases, support
for the creation of such committees comes from the highest levels. Latvia's
National Board on Information Society, for example, which includes educational,
scientific and business experts, is currently managed by Latvia's prime
In Tanzania, a nonprofit, public/private partnership, eThinkTank, was
formed in the absence of government IT leadership. While one private-sector
company organized the first meeting of eThinkTank, all of the public and
private partners that now participate in the group own it. This model worked,
and in less than one year, eThinkTank has received recognition, legitimacy,
funding and support from its national government, international governmental
organizations and international nonprofit organizations.
The need for e-government leadership will continue to grow as competition
among countries intensifies, as will the need for environments and officials
that welcome creative public/private partnerships.
McConnell, former chief of information policy and technology at the Office
of Management and Budget, is president of McConnell International LLC (www.mcconnellinternational.com).
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The Phoenix will be busy
I eagerly await the fulfilment of the next prediction, writes Kamal Dimachkie.
December 20, 2012 3:56 by kippreport
By Kamal Dimachkie
Another year is drawing to a close and a new one is looming on the fast approaching horizon. Such milestones tend to make people take stock more than on any ordinary day, and perhaps at this particular junction it is not without merit. It is also a time that arouses curiosity, especially concerning the New Year and what it will bring.
The Futurist Magazine has already released its ten forecasts for 2013 and beyond. The magazine's predictions are fascinating, but there were a few that are of particular interest. My favourite is how "Neuroscientists may soon be able to predict what you will do before you do it." I wonder if this is a precursor to the events dramatised in Minority Report and whether it will lead to the incarceration of people for crimes they have yet to commit.
I eagerly await the fulfilment of the next prediction. Apparently "the 'cloud' will become more intelligent, not only a place where you store data." I can't wait to experience all that such a development will enable us to do, and how much more it will allow us, I hope, to accomplish. There will certainly be many applications for this, and perhaps the field of medicine stands to gain the most and make the biggest human impact once the field of computing delivers this innovation. I suppose the flip side is that we need to worry more about programming and IT, but I am optimistic we will be the better for it.
On its surface, the next forecast is a bit of a paradox. It seems that "The economy may become increasingly jobless, but there will be more work." On the one hand it is expected that many recently lost jobs may not come back; on the other, and thankfully, many of those who have lost their jobs will be focusing on developing new skills, skills that will keep them busy and, hopefully, help them continue their economic upward mobility. What a relief.
Talk of the economy brings this conversation home to the Middle East North Africa region. It raises a myriad of topics, each of which rightly poses questions that beg to be answered. If you are curious, this area will keep you very busy. How will oil fare in 2013? What does the year have in store for the GCC and the individual countries? Which way will Syria turn out in the coming 12 months? How will Lebanon be affected? What is next for Palestine and the Palestinians? What will Egypt's cliff-hanger produce? Will the hard-earned democracy and the country's first ever vote confirm its commitment to progress, social development and economic prosperity?
Clearly, the above is just a sample, because there is quite a lot that is going on in the region. While the future concerns everyone, let's say that in our region we have more than our fair share to ponder. From the Gulf to the Atlantic, people in this part of the world have been on a rollercoaster ride, lurching from one issue to another, barely escaping one catastrophe only to discover that they have to deal with the next threat. A cursory look at any day's paper shows the spectrum of challenges that the people of this region deal with. In some countries the struggle is about staying alive. In others it's about earning daily subsistence. Another group struggles to obtain a modicum of human rights, equality and education, while yet another wants its voice to be heard over the thick cover of cultural norms.
And yet it is this very picture that inspires optimism and a ray of hope. Looking around the world, we see many examples of people dealing with adversity, overcoming it and moving on to build a future. Japan provides an inspiring example, its people having dealt with the double impact of tsunami and nuclear meltdown. That experience was obviously devastating, but the Japanese showed fortitude and put it behind them. In contrast, in our region, people must deal with a recurring daily cycle of challenges. The people of the Middle East often wake up to discover the previous day's work in ruins, and must pick up the pieces and build again. So the cycle continues.
In this region, each person who goes through such a life cycle must be like the Phoenix, ready to rise from yesterday's ashes with each new dawn. In the Middle East, the Phoenix is fit, experienced and tenacious, for nowhere else do people pick themselves up with the frequency that this region demands.
So, in the true spirit of a year winding down, and a new one approaching, I wish to make one prediction. I make it with the enthusiasm of a child about to open a present, I make it with faith in the indefatigable human spirit, and I make it with an optimistic eye on the future. The Middle Eastern Phoenix will indeed be busy, very busy, in 2013.
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Conceived and designed the experiments: EM JjS MK BNL SLSLK NWL FPN GF. Performed the experiments: EM MK. Analyzed the data: EM ADK JjS MK BNL SLSLK NWL FPN GF. Contributed reagents/materials/analysis tools: EM ADK MK BNL SLSLK NWL FPN. Wrote the paper: EM GF.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation. Cigarette smoke has been considered a major player in the pathogenesis of COPD. The inflamed airways of COPD patients contain several inflammatory cells including neutrophils, macrophages,T lymphocytes, and dendritic cells (DCs). The relative contributions of these various inflammatory cells to airway injury and remodeling are not well documented. In particular, the potential role of DCs as mediators of inflammation in the smoker's airways and COPD patients is poorly understood. In the current study we analyzed the effects of cigarette smoke extract on mouse bone marrow derived DC and the production of chemokines and cytokines were studied. In addition, we assessed CSE-induced changes in cDC function in the mixed lymphocyte reaction (MLR) examining CD4+ and CD8+ T cell proliferation. Cigarette smoke extract induces the release of the chemokines CCL3 and CXCL2 (but not cytokines), via the generation of reactive oxygen species (ROS). In a mixed-leukocyte reaction assay, cigarette smoke-primed DCs potentiate CD8+T cell proliferation via CCL3. In contrast, proliferation of CD4+T cells is suppressed via an unknown mechanism. The cigarette smoke-induced release of CCL3 and CXCL2 by DCs may contribute to the influx of CD8+T cells and neutrophils into the airways, respectively.
Chronic Obstructive Pulmonary Disease (COPD) is a multicomponent disease characterize by emphysema and/or chronic bronchitis [1]. The pulmonary component is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases [2].
COPD is mostly associated with cigarette smoking and thereby cigarette smoke is defined as a major risk factor [3]. Several inflammatory cells and their mediators, both of the innate and adaptive immune system, participate in the inflammatory response in COPD., Macrophages, neutrophils and CD8+ T cells are the cells usually considered the prime effector cells in pathogenesis of COPD [4], but recently DCs have been suggested to be a potentially important new player/orchestrator of the pattern of inflammation that characterizes of COPD [5].
In both humans and mice there are several subtypes of DCs, as characterized by surface markers and function. Generally, DCs can be distinguished into conventional DCs (cDCs) and plasmacytoid DCs (pDCs) [6]–[8] . cDCs are crucial antigen-presenting cells (APCs) for primary T-cell responses. They arise from bone marrow (BM) precursors that colonize peripheral tissues through the blood or lymph [9]. In vitro studies using bone marrow and monocyte-derived DCs exposed to varying doses of nicotine [10], [11] and cigarette smoke extract (CSE) [11] have yielded contrasting results with respect to their effect on DC function.
cDCs might play a central role in bridging innate and adaptive immunity via direct cell-cell interactions and/or cytokine production [12], [13]. These interactions may influence the activation status of cells from the adaptive immune system such as CD4+T cells and CD8+T cells [5], [7], [13]–[15] CD8+T cells could be essential for the development of cigarette smoke-induced COPD [12]. In this context, it has been reported that cigarette smoke in humans reduces DC maturation and function. Changes that favor repeated infection, increased exacerbation frequency, and the altered (CD8+T-cell predominant) pattern of inflammation associated with this progressive chronic disease [15]. Moreover, Robbins et al provided evidence that cigarette smoke exposure causes specific defects in DC maturation and suppresses the proliferation of CD4+T cells in thoracic regional lymph nodes in mice [13].
To investigate the effect of cigarette smoke on cDC, these cells were incubated with CSE and different chemokines and cytokines were measured and accordingly the molecular mechanisms were studied. In addition, we assessed CSE-induced changes in cDC function in the mixed lymphocyte reaction (MLR) examining CD4+ and CD8+ T cell proliferation.
GM-CSF was purchased from PeproTech (London, UK). Trizol and SuperScript II were purchased from Invitrogen (CA, USA). Sybrgreen Universal PCR Master Mix was obtained from ABgene (Hamburg, Germany). LPS, propidium ionide (PI), N-acetylcysteine (NAC), SB 239063, and curcumin were obtained from Sigma-Aldrich (Zwijndrecht, The Netherlands). The CCL3, CXCL2, MCP-1, KC ELISA kits, neutralizing antibodies for CCL3 and CXCL2 were purchased from R&D systems (Oxon, UK). Mouse inflammatory and Th1/Th2 cytokine beads array (CBA) kits, annexin V, 7-AAD were purchased from BD (Alphen, The Netherlands). Rabbit polyclonal antibody against IκB-α and p65 were obtained from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands). Mouse monoclonal antibodies specific for JNK/SAPK, phospho-Erk1/2, β-actin, phospho p38, p38, phospho c-jun and c-jun were obtained from Cell Signaling (Leiden, The Netherlands). Functional Grade Purified anti-mouse Toll-like receptor 4 (TLR4)/MD-2 (Clone: MTS510 0) and isotype control (Rat IgG2a, κ) were purchased from ebioscience (San Diego, CA, USA). ATF-2 and c-fos and lamin C were obtained from Stressgen (Uden, The Netherlands). Horseradish peroxidase (HRP)-conjugated rabbit-anti mouse IgG, mouse anti-rabbit and goat anti-rabbit IgG were purchased from Dako (Heverlee, Belgium). A nuclear and cytoplasmic extraction kit, super blocking buffer and bicinchoninic acid (BCA) protein assay kit were purchased from Pierce (Amsterdam, The Netherlands). CFSE dye and miniTM protease inhibitors were obtained from Molecular Probes (Eugene, OR, USA) and Roche (Almere, The Netherlands), respectively.
Ten- to 12-week-old Balb/c or C57BL/6 and MyD88 knockout mice (kindly provided by Dr. S. Kunkel) were purchased from The Jackson Laboratory (ME, USA) and maintained in the pathogen-free Central Animal Facility of the University of Utrecht and University of Michigan. All experiments were approved by the University Utrecht and University of Michigan Committee on the Use and Care of Animals.
CSE was produced following the method as described before [16]. Nontoxic concentrations of CSE were assayed performing toxicological assays (lactase dehydrogenase) and flow cytometery analysis (annexin-V and 7-AAD staining). We also performed a dose–response to establish the effect of different CSE concentrations on chemokine and cytokine release of cDCs. No toxic effects of up to 1.5% concentration of CSE was found since viability was consistently established to be >95% (trypan blue exclusion).
The method for generating BM-derived cDCs was modified (for higher purity) from that described originally by Inaba and coworkers [17].
Cells at 9 days of culture were washed and pre-incubated with pharmacological inhibitors for 30 min, and then stimulated with CSE (1.5%) or LPS (100 ng/ml, positive control) for 30 min for protein expression in cytoplasmic and nuclear fraction, for determination of chemokines at mRNA or protein levels by ELISA and Real time-PCR, at 4 and 16 h, respectively. For MLR, cDC were incubated with CSE (1.5%) for 24 h and then washed and co-cultured with CD8+ and CD4+T cells for 72 h.
CCL3, CXCL2, MCP-1 and KC at protein concentrations in supernatants of cells were quantified using ELISA kits according to the manufacturer's instructions. To quantify the inflammatory cytokines (TNF-α, IL-2, IL-6, IL-10, IL-12p70, MCP-1, IFN-γ), 50 µl of culture medium were subjected to CBA kits by using FACS analysis according to the manufacturer's instruction.
Total RNA was extracted from cDCs by using Trizol according to standard protocols. Reverse transcription was performed with SuperScript II. For real-time RT-PCR, cDNA was analyzed for the expression of CCL3, CXCL2 and GAPDH/B2M genes using Sybrgreen using an ABI Prism 7000 Sequence Detection System (Applied Biosystems) under conditions of 50°C for 2 minutes, 95°C for 10 minutes, then 40 cycles of 95°C for 15 seconds and 60°C for 1 minute. The sequences for PCR primers (Eurogentec) were used as described before [18], [19].
Intracellular ROS levels were measured by flow cytometry in cells cultured in serum-free medium and loaded with the redox-sensitive dye DCFH-DA (D399) [20]. Thirty minutes before the end of each incubation period, cells were incubated with 10 µM DCFH-DA in dark. Cells were thoroughly and quickly washed with PBS and immediately acquired for analyzed for fluorescence as described before [20], [21] by FACSCalibur (BD Bioscienes). The data were plotted and analyzed using CellQuest software. PMA at concentration 0.1 µg/ml used as a positive control.
Cells were washed twice with PBS and layzed with cytoplasmic extraction reagent containing protease inhibitors (MiniTM protease inhibitors, cocktail).as described before [22]. Protein concentrations were determined by using a bicinchoninic acid (BCA) protein assay kit (Pierce).
After activation, cDC were washed once with PBS and lysed in lysis buffer containing MiniTM protease inhibitors. The lysate (25 or 50 µg) was subjected to SDS/PAGE [10% (w/v) gel] and blotteing as described before [22]. After blocking the membranes with blocking buffer, the membranes were probed with antibodies in recommended concentration as described in usage instruction antibodies. After three washes with TBS-T, membranes were treated for 1 h with HRP-conjugated indicated antibodies diluted to 120,000 in TBS-T. After three washes with TBS-T, immunoreactive protein bands were revealed with an ECL and ECL Plus (Amersham). Films were scanned and analyzed on a GS7-10 Calibrated Imaging Densitometer equipped with Quantity One v. 4.0.3 software (Bio-Rad).
We analyzed NF-κB and AP-1 activation by using the Trans-AM NF-κB p65/NF-κB p50 and AP-1 Transcription Factor Assay Kit (Active Motif, Rixensart), respectively, according to the manufacturer's instructions.
cDCs (from Balb/c mice) at day 8 were pretreated with CSE (1.5%) for 24 h and then used to stimulate CD4+T cells or CD8+T cells (from C57BL/6 mice) . The MLR was conducted in round-bottom; 96-well micro test plates in 0.2 ml of RPMI with (10%) FCS in the continued presence of the blocking mAb at 20 µg/ml. Graded doses of cDCs were added as indicated in Results section. To monitor the MLR, the CD4+T cells or CD8+T cells were isolated from spleen by using CD4+ and CD8+T cell isolation kits (Miltenyibiotec) and then cells (5×107/ml) loaded with the proliferation-tracking dye CFSE at a concentration of 4 µM in phosphate-buffered saline for 15 min at 37°C. Labelled cells were then washed three times. The MLR was assessed by CFSE dilution after 72 h after co-culturing with T cells by FACS analysis. For FACS analysis, cells were washed and labelled with CD3 conjugated with APC, CD4+ and CD8+ conjugated with PE antibodies plus PI for 30 min. Then after 2 times washing with FACS buffer (PBS, 5% FCS, 0.1% sodium azide) the proliferation of T cells were measured by flow cytometery. T To determine the production of IL-2 induced by CSE-conditioned cDCs, supernatants of T cells were harvested for measurement of IL-2.
Using neutralizing antibodies directed against CCL3 or CXCL2, we investigated the role of these chemokines in MLR response of CSE-primed cDC. cDC were pretreated with CSE for 24 h and then were washed with PBS and treated with 10 µg/mL anti-CCL3 or 0.1 µg/ml anti CXCL2 antibodies or control IgG antibodies for 30–60 min at 37°C. Thereafter, cells were subjected to MLR as described before.
Experimental results are expressed as mean±S.E.M. Results were tested statistically by an unpaired two-tailed Student's t-test or one-way ANOVA, followed by Newman–Keuls test for comparing all pairs of groups. Analyses were performed by using GraphPad Prism (version 4). Results were considered statistically significant when p<0.05.
CSE dose dependently (0.035–2.5%) induced the release of chemokines (data not shown). The CSE concentration of 1.5% is most effective in inducing chemokines release from cDCs (Fig. 1A and B, upper panels). Therefore, this concentration was used in all subsequent experiments. Stimulation of cells with CSE (1.5%) did not induce significant TNF-α, IL-2, IL-6, IL-10, IL-12p70, MCP-1 and IFN-γ production (data not shown). CSE-induced CCL3 and CXCL2 production is associated with an increased in mRNA levels for both chemokines (Fig. 1A and B, lower panels). To investigate the involvement of ROS and oxidative stress in the production of CCL3 and CXCL2 by CSE-exposed cDCs, the effect of the antioxidant agent N-Acetyl-Cysteïne (NAC 2.5 mM) was investigated.
NAC attenuated the production of CCL3 and CXCL2 induced by CSE (Fig. 1A and B). Furthermore, intracellular ROS production after CSE treatment was measured. Exposure of cDCs to CSE or PMA, as a positive control, resulted in the production of ROS (Fig. 2). Pretreatment of cDCs with the antioxidant NAC resulted in an inhibition of CSE-induced ROS production (Fig. 2).
We and others have demonstrated that CSE activates inflammatory cells via TLRs [16], [23]. By using neutralizing antibody against TLR4, the releases of CCL3 and CXCL2 was decreased (Fig. 3A and B).
MyD88 is a critical adapter molecule for the transduction of TLRs signals [24]. Therefore, cDCs lacking MyD88 were investigated. CSE did not induce the release of CCL3 and CXCL2 from cDCs obtained from MyD88 knockout mice (Fig. 3C and D). Similarly, LPS, the positive control did not induce a response in MyD88 −/− cDCs (Fig. 3C and D).
It has been reported that CSE activates MAPK and NF-κB in many inflammatory cells [25]–[27]. Therefore, in the current study, the involvement of these pathways were investigated. CSE stimulated phosphorylation of the JNK/SAPK, Erk1/2 and p38 pathways in cytoplasm of cDCs (Fig. 4A). In addition, NAC abrogated the phosphorylation of all these molecules. Next, the effect of pharmacological inhibitors were examined on chemokine release after CSE stimulation. Inhibition of p38 MAP kinase by SB 239063 induced a 63%±17 and 43%±31 reduction of CSE-induced CCL3 and CXCL2 production by cDCs, respectively. Inhibition of Erk1/2 by PD98059 induced a 28.4%±2 and 29%±16 reduction in CCL3 and CXCL2 production, respectively. In the nuclear fraction, CSE increased the phosphorylation of c-jun, c-fos and ATF-2 in cDC (Fig. 4B) and addition of NAC abrogated the phosphorylation of these molecules (Fig. 4B).
CSE and LPS (the positive control) significantly increased the activity of AP-1 compared to control. Pre-incubation of cells with NAC, suppressed the activation of AP-1 induced by CSE (Fig. 4C).
Further, the regulation of NF-κB signaling in cDCs by CSE was investigated. To address the mechanism involved in the degradation of IκB-α by CSE, phosphorylation of IκB-α by Western blot analysis was examined. CSE or LPS (the positive control) increased IκB-α phosphorylation (Fig. 5A) and exposure to CSE or LPS resulted in the degradation of IκB-α (Fig. 5A). Pretreatment with NAC inhibited the CSE-induced phosphorylation and degradation of IκB-α (Fig. 5A). In the nuclear fraction CSE and LPS increased the nuclear translocation of p65 which was abrogated by NAC (Fig. 5B). Pretreatment of cDC with the pharmacological NF-κB inhibitor (curcumin) resulted in an 80%±3 reduction of the chemokine production (data not shown). For determination the activity of NF-κB, nuclear proteins were subjected to a reaction containing biotin conjugated-oligonuclotides NF-κB. CSE increased the activity of NF-κB in cDCs and pretreatment with NAC suppressed NF-κB activity (Fig. 5C).
CSE significantly increased the ability of cDCs to stimulate the proliferation of CD8+T cells compared with untreated cDCs (Fig. 6A) and decreased proliferation of CD4+T cells (Fig. 6B). In a reciprocal fashion, the MLR was also determined by using T cells exposed to CSE. CSE did not effect proliferation of T cells (CD4+ or CD8+T cells) when co-cultured with untreated allogeneic cDCs (data not shown). To further characterize the effect of CSE on the priming capacity of cDCs, the effect of CSE on IL-2 production in the MLR was assessed. As depicted in Fig 6A upper panels, IL-2 production of CD8+T cells was increased and decreased by CD4+T cells (Fig. 6B, upper panel).
Finally, the involvement of CCL3 and CXCL2 in MLR reaction were investigated.
cDCs were exposed with CSE for 24 h, treated with neutralizing antibodies directed against CCL3 or CXCL2 and were then subjected to MLR reaction. Incubation of neutralizing CCL3 antibody in MLR, profoundly suppressed the CSE-primed cDC–induced proliferation of CD8+T cells in the MLR (Fig. 7). Incubation with CCL3 antibody did not affect the CSE-primed cDCs-induced reduction of CD4+T cell proliferation (data not shown). Moreover, the effects of CXCL2 neutralizing antibodies on the MLR with CSE-primed cDCs and CD8+ or CD4+T cells were investigated. CXCL2 antibody had no effect on the proliferation of CD8+T cells or CD4+T cells when co-cultured with CSE-primed cDCs (data not shown).
In this study, the effects of CSE on cDCs were explored with particular emphasis on the function and cellular immune responses. Among the tested cytokines and chemokines, CSE induced the release of CCL3 and CXCL2 by a ROS dependent manner. Interestingly, CSE did not induce the production of TNF-α, IL-2, IL-6, IL-10, IL-12p70, MCP-1, IFN-γ and even suppressed the production of these cytokines induced by LPS (data not shown). Similar data on IL-12 and IL-23 have been published by Kroening et al, [28]. Our findings are consistent with the work of others showing the induction of IL-8 by CSE or cigarette smoke in human pulmonary DCs and in an in vivo model of smoke exposed mice [29].
Moreover, we show for the first time that CSE modulates cDC-mediated of T cells and specifically augments proliferation of CD8+T cells and inhibits proliferation of CD4+T cells in MLR. The increase in proliferation of CD8+T cells is mediated by CCL3, since the increase in proliferation is inhibited by antibodies against CCL3. CXCL2 antibodies did not have an effect (data not shown).
Cigarette smoke contributes to oxidant-induced damage of the cells via oxidants and free radicals [30] and generation of intracellular ROS [31]. We showed, that CSE induces ROS production in cDCs leading to the production and release of CXCL2 and CCL3. Interestingly, the generation of chemokines by cigarette smoke-activated DCs could be mitigated by anti-oxidants, NAC treatment. These data indicate that anti-oxidant therapy with agents like NAC may effect cigarette smoke-induced chemokine release of cDCs.
Next we found that MyD88/TLR4 activation and NF-κB/MAPK signaling is involved in the induction of chemokines by CSE in cDCs. The first signaling protein to be recognized as oxidative stress-sensitive molecules are transcription factors, such as NF-κB [32] . ROS strongly affects the activation of NF-κB [32]. Besides, the MAPK pathway is an important signaling pathway affected by CSE [26]. In the current study, CSE induces the release of chemokines by both the activation of NF-κB and the MAPK pathways since inhibition of these intracellular signaling pathways suppresses the release of both chemokines. Chemokines regulate the movement of leukocytes such as neutrophils and lymphocytes [33]. The predominant chemokine for human neutrophils is the CXC chemokine CXCL8. Mice lack CXCL8 but have the neutrophilic CXC chemokine ligand 2, MIP-2 or CXCL2 [34]. The importance of this chemokine in promoting pulmonary inflammation associated with COPD has extensively been investigated in vitro and in vivo [35]–[37]. Therefore, the CSE-induced release of CXCL2 by cDCs may result in the infiltration and activation of neutrophils in the airways.
Interestingly, in current study we show that CSE-primed cDCs increase the proliferation of CD8+ and suppress CD4+T cells proliferation. In the supernatants of MLR samples the IL-2 production is elevated in CD8+T cells which is in agreement with the proliferation of cells. These data could explain the enhanced CD8+T cell population observed in lungs of smokers and smoke-treated mice [37]–[39]. Until now, the mechanism for this process is not well documented. Maeno and coworkers, described a critical role for CD8+T cells in inflammatory cell recruitment and lung destruction in a cigarette smoke-induced murine model for COPD [12]. Earlier evidence reported that CCL3 is involved in CD8+T cell proliferation [40]. Interestingly, CCL3 production by cDCs after CSE stimulation has a central role in the induction of the proliferation of CD8+T cells since proliferation was blocked by adding CCL3 neutralizing antibody. Moreover, CSE-primed cDCs suppress CD4+T cells proliferation which is agreement with recent in vivo studies [38]. The role and amounts of CD4+T cells in COPD is not well documented but early studies reported that cigarette smoke exposure led to a specific decrease in the percentage of activated CD4+T cells, but not CD8+T cells in the lung [37]. Interestingly, very recently, Harissison et al reported that the total number of BAL CD4+ and CD8+T cells is higher in mice exposed to cigarette smoke. Furthermore, CD4+T cells were proportionally higher than CD8+T cell [41]. We tested the effects of neutralization antibodies against CCL3 and CXCL2 on the decreased CD4+ T cell proliferation induced by CSE-primed cDCs and did not find any suppressive effects on (data not shown). The reasons for the above mentioned discrepancies are not clear. The decrease in proliferation of CD4+T cells may indicate suppressive effects of cigarette smoke on immune responses and may account for the higher susceptibility of smokers to viral and bacterial infections [42], [43].
The above-mentioned explanation for the regulation of proliferation of T cells by CSE primed-DCs is an over simplification and is mainly used as a working hypothesis. In summary, cigarette smoke induces the release of CXCL2 and CCL3 by cDCs. CXCL2 is considered as a chemokine that can recruite neutrophils. CCL3 results in the proliferation of CD8+T cells and may be a key factor for increasing this cell in smokers and COPD patients. However, the relevance of above mentioned data should be confirmed in animal model with COPD and human.
Competing Interests: The authors have declared that no competing interests exist.
Funding: This study was performed within the framework of Dutch Top Institute Pharma (project numbers T1-103 and D1.101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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* Benson
Shirley Meaning
Quick Facts
No. Of Syllables:2
No. Of Letters:7
Origin & Meaning
The meaning of Shirley is "bright meadow".
View the Shirley Name Popularity Page to see how the popularity trend for Shirley has changed since 1880, or to compare the popularity of Shirley to other names.
It may all be in the numbers.
The numbers that make up your child's name.
Children named Shirley are often excitable and direct but most of all they are read more >>
Related Names
Variants of the name Shirley include Sherily, Sherl, Sherle, Sherlee, Sherleen, Sherlene, Sherley, Sherli, Sherlie, Sherline, Sherly, Shirlee.
Other Tidbits
Shirley falls into the flower name category.
Some famous bearers of this name include: Shirley Temple, Shirley Jones, Shirley Booth, Shirley Chisholm.
Name Fun
Then just follow the diagram below.
Just for fun, see the name Shirley in Hieroglyphics, learn about ancient Egyptian Hieroglyphics and write a Hieroglyphic message.
Learn about nautical flags and see your name or message written in nautical flags, on the Shirley in Nautical Flags page.
Names Like This
Biblical names are still very prevelant. Nature, literature, mythology, celebrity, surnames, variants of traditional names and newly invented names are all sources of English given names.
The evolution of English names in the U.K. can be traced to the various conquests and ruling power changes of its early history. The evolution of English names in America has been more influenced by the various influxes of immigrants from different parts of the world during different times in its history.


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Nice graphics. I like the art style.
Featuring a unique interactive narrative style and imaginative hand-painted environments, Bastion challenges you to build a new world from the broken remnants of the past.
This batch of Bastion screens is taken straight from various areas from the game. Included are a couple of never-before-seen foes and environments as well as a new weapon, the Scrap Musket.


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Lyrics Depot is your source of lyrics to She Cried by Kenny Price. Please check back for more Kenny Price lyrics.
She Cried Lyrics
Artist: Kenny Price
Album: Charlotte Fever
The first time I kissed her she cried and said I bet I'll still love you after I die
When we were married she cried then too
And I could hardly hear through all her tears when she said I do
When she first held our baby she cried
And insisted he be named after me for he had my eyes
[ steel ]
But to some people's life autumn comes early and God will let a favorite flower die
And I miss her so but Lord she's happy I know
For just before she left she said I'll miss you then she cried
Kenny Price Lyrics
Kenny Price Charlotte Fever Lyrics
More Kenny Price Music Lyrics:
Kenny Price - After All Lyrics
Kenny Price - Alice In Wonderland Lyrics
Kenny Price - Downtown Knoxville Lyrics
Kenny Price - It's Such A Pretty World Today Lyrics
Kenny Price - Raindrops Keep Fallin' On My Head Lyrics
Kenny Price - Something To Believe In Lyrics
Kenny Price - Sugarfoot Rag Lyrics
Kenny Price - Walk On Out Of My Mind Lyrics


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Posts from Candy
12 Ways to Use Up Candy Canes
Sweet Tips from The Kitchn
They appear just once each year, but what to do when you're stuck with more candy canes than you know what to do with? Rather than tossing these festive sweet treats, transform them into baked goods and even cocktails and use up every last (even broken) piece! Read on for some creative uses for your leftover candy canes this holiday season.
5 Gingerbread Houses That Will Totally Amaze You
Gingerbread houses are the ultimate blend of baking skill and craftiness during the holidays. Assembling even the most basic house takes patience, precision, and creativity. But these inspiring houses are far from basic.
From an urban townhouse to a gingerbread farm (there are even ponies) to a dreamy mountain chalet, these five gingerbread houses will totally amaze you!
Recipe: Chocolate Chip Cookie Bark
Edible Gift Recipes from The Kitchn
Cookie-baking season is in full swing, but I'm going the no-bake route this year! Instead of turning out sheets of sugar cookies, I've been melting chocolate into batch after batch of holiday bark — first with this White Chocolate Cheesecake Bark, then with this Elvis Bark, and now today's Chocolate Chip Cookie Bark.
This version is my favorite so far. White and dark chocolate get swirled together to form the base (so pretty!), and a confetti of cookies, chopped walnuts, and mini chocolate chips is scattered on top. This is an easy homemade gift and a gorgeous addition to any holiday dessert tray.
Eggnog Caramels?! This All-Caramel Cookbook Tells Us How
New Cookbook First Look
The book: Artisan Caramels by Sandy Arevalo
The angle: All caramels, all the time. Go get yourself a pan.
Recipes for right now: Pumpkin Pie Caramels, Hot Chocolate Caramels, Tiramisu Caramels, Stout and Pretzel Caramels, Eggnog Caramels, French Toast Caramels with Bacon, Cinnamon Roll Caramels
Who would enjoy this book? Caramel lovers.
Recipe: Elvis Chocolate Bark
Gift Recipes from The Kitchn
It is widely known that the crowned King of Rock 'n' Roll loved peanut butter-and-banana sandwiches. With or without bacon, he enjoyed them often — they were one of his favorite indulgences at home and on the road. In homage to this delicious snack, here's a holiday bark, fit for Elvis himself!
Recipe: Eggnog Marshmallows
Gift Recipes from The Kitchn
You know what it's like. You've been invited to a dinner party, and suddenly you're wondering what, exactly, you should bring the host — a bottle of wine, some nice olive oil, a candle? See, that's usually my dilemma — that is, up until two years ago when I realized that marshmallows make the perfect gift this time of year. And these eggnog marshmallows, in particular, will guarantee you get an invite to the next party.
5 Beautiful Ways to Package Homemade Cookies and Treats
Tips from The Kitchn
Making cookies and treats for the holidays has always been the easy part for me. I can organize a shopping list, prep, freeze, and bake with great speed and efficiency and generally enjoy the whole process.
The packaging of it? Not so much for this creatively challenged baker. I want all my hard work to shine and for my cookie gifts to look and feel special, but I just don't have the patience or talent to do something complicated. Here are five fun ways to package up your homemade treats that even I am excited to try out!
Recipe: Holiday Nut & Fruit Brittle
Edible Gift Recipes from The Kitchn
Every year around this time, I start making big batches of cookies, candies, and other edible gifts, package them up with festive bows and baker's twine, and give them to friends and family. This season, I made this Holiday Nut & Fruit Brittle. It's perfect for gifting and so versatile, using whatever nuts or dried fruit you have around.
Recipe: White Chocolate Cheesecake Bark
Edible Gift Recipes from The Kitchn
We're officially into the holiday season, and if you're doing a DIY gift exchange with your friends this year, you should definitely think about making a batch of chocolate bark. This sweet treat is quick and easy to whip up, and it makes a beautiful gift simply layered in a pretty container.
For a change from my usual bark, this year I'm making this cherry cheesecake twist. White chocolate gets a tangy lift from lemon zest, and it's topped with crisp graham crackers, crunchy sliced almonds, and chewy, sweet dried cherries. The combination of textures and flavors is so irresistible, you should probably make a double batch and keep some for yourself!
Get Ready to Channel Your Inner Willy Wonka with This Cookbook
New Cookbook First Look
The book: Sweet Things by Annie Rigg
The angle: Little sweet treats to make and gift.
Recipes for right now: Bitter Orange Chocolate Truffles, Caramel Nougat Bars, Peppermint Creams, Toasted Coconut Marshmallows, Turkish Delight, Cherry Brandy Fudge, Almond and Pistachio Turron, Candy Canes
Who would enjoy this book? Those who want all the candy in the candy shop.


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Music to Your Ears
By Laura Marrich
We Will, We Will Rocku--Since the first time I laid eyes on This Is Spinal Tap by Christopher Guest, I've derived way too much pleasure from watching musicians in their meteoric rise to fame and inevitable, cataclysmic fall from grace. Mock or not, rockumentaries rule. This weekend, the Santa Fe Film Festival will screen nine original films (some made right here in New Mexico!) that shine a spotlight on music. We Like to Drink: We Like to Play Rock 'n' Roll follows The Unband, three alcoholic men-children who like to play loud, lewd rock music, as shot by Tesuque-based documentary filmmaker Lexie Shabel. Dangerous Highway gives voice to the "greatest unknown musician you've never heard," guitarist Eddie Hinton. Fellini-esque Russian filmmaker Rustam Khamdamov does a study of his country's stunning operatic talent in Vocal Parallels. Novem is an honest-to-god mockumentary about a confederacy of college songwriters in the '70s (it won the Jury Prize for best indie film in Sonoma). Bob Dylan's hometown of Hibbing, Minn., gets rifled through by Natalie Goldberg and filmmaker Mary Feidt in Tangled Up in Bob, while native musicians from northern New Mexico are the partial focus of Native Spirits: Forgotten Warriors. Finally, Life in G-Chord is the bittersweet account of Hisao Shinagawa, a Los Angeles street musician who still dreams of the stardom he chased upon first entering America in 1974. Log on to www.santafefilmfestival.com for a complete schedule of the films.
Flyer on the Wall
Lobster Claw!
The Dead Electric would like nothing better than to make out with you. With Unit 7 Drain and Roman Numerals, Saturday, Dec. 9, at Burt's (21-and-over). Free. (LM)
Cuong Vu: Mixing the Menacing and the Ethereal
Trumpeter's trio builds music on fearless trust and intuition
By Mel Minter
Trumpeter Cuong Vu attacks his instrument with a ferocious intensity usually reserved for rock guitars, and he uses many of the same electronic processors favored by adventurous guitarists from Jimi Hendrix to Bill Frisell.
Danielle St. Laurent
Show Up!
Drop-Kickin' It with The Faint
An interview with bass-master Joel Petersen
By Lash Bower and Amy Dalness
Two Faint fans, one Faint interview. A dilemma only determined fairly by duel. Given that duels are illegal, Lash and I went mano y mano for the right to interview bass player Joel Petersen.
Club Alegria Goes Out with Public Enemy's Bang
By Marisa Demarco
One fall day in Santa Fe, Zia Cross had just finished with her volunteer shift at the High Mayhem music festival and ran across the street to Alegria Liquor. Cross found herself chatting with George Rivera, the shop's owner. She pressed him about what he was doing with the beautiful club space, empty for three years, that's attached to his store. Nothing, she remembers him saying. You do something.
Sonic ReducerKeith Drummond Kornfield Invalid Love · Tom Waits Orphans · Jay-Z Kingdom Come
By Marisa Demarco
He's a surly man, this Mr. Kornfield. No matter: On this disc, it's working for him. The country-fried singer/songwriter smothers typical twang with killer lyrics, the perfect balance of heartfelt and cynical. Like only the best bards can, this guy strings you pleasantly along only to turn on you with a suckerpunch of melancholy. Drummond's been in this town for a while, a part of acts like Saddlesores, Speed Queens, Jet Girls and Dueling Keiths. Maybe that history's got something to do with my favorite track on Invalid Love, "Rock-n-Roll Sucks." Check out www.kingoftheworldmusic.com or head to Natural Sound for a copy.
via morguefile
EVENT HORIZON (Friday, May 6)
Floating on Cloud Nine
Infrequency • trance • Graeme Byous • electronica, progressive • AnthonyMarx 9 • house
By Megan Reneau
As a society we can agree that we're ready for a heightened consciousness. In my experience, that is achieved through music–specifically trance. On Friday, May 6, at 9pm you can be lifted up physically, by climbing the stairs up to the mezzanine at the Historic El Rey Theater, and mentally, after listening to the rhythms and noise from AnthonyMarx, Graeme Byous, and Infrequency…
via Rock Jong Il's Facebook Page
EVENT HORIZON (Saturday, May 7)
Rock Jong Il Rocks Out
Rock Jong Il • punk • Suspended • metal • Russian Girlfriends • rock • Get Action • punk
By August March
On Saturday, May 7, put down that Communist Manifesto you've been perusing and take a stroll Downtown to Launchpad for the album release party of Rock Jong Il. The quintet of local rockers and stalwart party members are having a fete to celebrate the recording Dictators of Rock. Longtime members of the anti-capitalist forces seeking a rock and roll revolution…
Today's Events
Infrequency • trance • Graeme Byous • electronica, progressive • AnthonyMarx 9 • house at Historic El Rey Theater
Tex-New-Mex Latin Fest • Jimmy Edwards • Grupo Avizo • Roberto Griego • Latin, variety at Legends Theater @ Route 66 Casino
SWAG duo • jazz, blues, Motown at Sheraton Uptown HotelMore Recommended Events ››
Out of the Woodwork • 6.2.2016
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text:
Cicada Princess
USA, 2012, 7 Minute Running Time
Topics: Animation, FantasyLanguage: English English Sub-Titles
For sixteen years, cicadas live underground, emerging for one glorious night in hopes of finding happiness and maybe… love.
DIRECTOR: Mauricio Baiocchi
Editor: Russ MillerScreenwriter: Mauricio BaiocchiCinematographer: Ray Gilberti
Amazing Animation
85 min.
Eight visually dazzling tales to tantalize your eyes and mind, covering a wide gamut of subject matter, from a fin du siècle painters' muse to an Indian God to a young girl who collects all manner of trash and trivia. Truly amazing animation.... more


text: Early on, I had used up my "ignore user" allotment. Now that we are further along and the group dynamics have changed, I'd like to reboot my ignore users without having to track them all down and "unignore" in individual posts. Is there a way to reset this? Is there a place in my profile to view the users I am ignoring? How many users can a member ignore at one time?


text: While it may come as a shock, Chuck Norris does not go home to a tricked out, blast-proof log cabin in the woods every night. He, in fact, lives in a very nice, shockingly charming 7000+sqft ranch-style home in Dallas. But not for long, because now it's on the market, and it could be yours for a mere $1.2M. Let's take a peek inside:


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Class 4A (Track) Girls Tennis Schedule and Standings
Recent Class 4A (Track) Prep Girls Tennis Results
0 prep girls tennis meets for 04/08/2016 - 05/06/2016
This week's Class 4A (Track) Girls Tennis Schedule
0 prep girls tennis meets for 05/06/2016 - 05/07/2016
Girls Tennis Standings
Girls Tennis does not have standings, though it does have leaders. View Girls Tennis leaders here.
Preps Blogs
Colorado Prep Blog Analysis and Notes
Eaglcrest hires in house; Robby Gabrielli to head girls basketball
5A Raptors hire boys assistant to head girls...
- Rocky's Austin Alarid called it a beautiful day for baseball at Coors -- and acted like it (posted 2 days, 19 hours ago)
- 7-on-7 Future Stars Football Camp set for fourth- and fifth-graders (posted 3 days, 17 hours ago)
- Chris Jonson takes over Class 5A Lakewood Tigers volleyball (posted 3 days, 19 hours ago)


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Pointe-des-Monts to Anticosti - northern half
Marine Forecast
Issued 03:42 PM EDT 01 May 2016
Tonight and Monday
Wind light becoming northeast 10 to 15 knots near midnight.
Issued 03:00 PM EDT 01 May 2016
Tonight and Monday Seas 1 metre or less.
Extended Forecast
Issued 06:00 PM EDT 01 May 2016
Tuesday Wind east 10 to 20 knots.
Wednesday Wind east 10 to 20 knots becoming east 20 late in the day.
Thursday Wind east 20 knots.
Ice Forecast
Issued 10:00 AM EDT 1 May 2016 Today Tonight and Monday Open water except 2 tenths of first-year ice in some bays.
Stay connected
Weather Conditions
Zoom-in to make a selection
Land Station
Ice Conditions
Ice ForecastsIssued 10:00 AM EDT 1 May 2016 Today Tonight and Monday
Ice EdgeIce edge estimated from Quebec near 5000N 6650W to 5000N 6000W to
5120N 5720W to Newfoundland near 5030N 5725W. Sea ice north and east
of the ice edge.
Ice Coverage
Open water except 2 tenths of first-year ice in some bays.
No watches or warnings in effect.
Technical Marine SynopsisIssued 3:00 PM EDT 1 May 2016 Tonight and Monday At 3:00 p.m. EDT today ridge located from Hudson Bay to the Gulf
of Maine.
By 8:00 p.m. EDT Monday ridge located from Ungava Bay to
At 3:00 p.m. EDT today low 1013 mb located south of Lake Erie.
By 8:00 p.m. EDT Monday low 1009 mb located over the Gulf of Maine.
Atlantic - Maritimes Area
- Anticosti - northeastern half
- Anticosti - southwestern half
- Banquereau
- Bras d'Or Lakes
- Browns Bank
- Cabot Strait
- Chaleur - Miscou
- Eastern Shore
- East Coast - Cape St. Francis and south
- East Scotian Slope
- Fourchu
- Fundy
- Georges Bank
- Grand Manan
- Gulf - Magdalen
- Gulf - Port au Port
- Halifax Harbour and Approaches
- LaHave Bank
- Laurentian Fan
- Lurcher
- L'Isle-aux-Coudres to Tadoussac
- Northumberland Strait
- Pointe à Michel to Pointe-des-Monts
- Pointe-des-Monts to Anticosti - northern half
- Pointe-des-Monts to Anticosti - southern half
- Sable
- Southeastern Grand Banks
- Southwestern Grand Banks
- Southwestern Shore
- Southwest Coast
- South Coast
- Tadoussac to Pointe à Michel
- West Scotian Slope
Another Region
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2 of 3 people found the following review helpful
A woman's work,
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This review is from: The Complete Poems of Emily Dickinson (P. S.) (Annotated) (Kindle Edition)
As a female business and executive coach and previously a high school principal I understand only too well the frustrations of a world that doesn't always fit. Emily and her ideal of being a poet didn't really fit in her time or in her family. There are lots of suppositions about her strange nature and her refusal to engage in domestic chores as she considered herself to be a poet. I love her poetry because it doesn't really care about rules. There are no titles only numbers. the punctuation is mainly ellipsis , little dashes. when I write poetry I distinctively do that , I don't want to punctuate, i want to express, i want to say and i want to feel the words not control them. so if you are looking for a different style of writing you have certainly found it in Emily. I love this idea, " I would not stop for death so he kindly stopped for me" - I think it speaks so strongly of our haste today. Much of Emily's work has this very contemporary feel. Her writing is a powerful reminder of the frustrations that women felt about being served up to men as a prize. this was a time when marriage was the strong expectation for all women. Emily bucked this trend too. She had suitors but never did marry. I would strongly recommend any student of literature, life or women to pick this up. As an executive and business coach I have found that my women clients enjoy being introduced to Emily as a model to think for themselves and not to be defined by the culture around them or indeed by the expectations of others. My motto is "define yourself, it's later than you think" ! I believe there is a gap without her work. Enjoy.
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The Sarasota/Manatee Chapter and HLAA Dual Membership is the holiday bargain of the year!
HLAA of America gives back all year long–
• Provide timely and reliable information about hearing loss through HLAA's website, Hearing Loss Magazine, HLAA e-News, the Hearing Loss Support Specialist Training, message boards/chat forums and the HLAA Convention
• Advocacy at the national level to affect legislation that impacts people with hearing loss, whether it's funding for hearing aids, cochlear implants, communication access in public places or other important issues
• A nationwide network of chapters and state organizations providing peer support
• Support for parents of children with hearing loss at www.kidsandhearingloss.org
• Outreach to veterans returning with hearing loss
Our Chapter and its volunteers give back every month
• Captioning and hearing assistive technology at HLAA chapter meetings to make them accessible
• Scholarships to the National HLAA Convention
• Free membership and programs for Veterans
• Installation of loops in public places, such as theatres, community rooms, Publix and public libraries
• Seminars on coping with hearing loss for yourself and families
Membership applications can be found at the Chapter website, http://hlas.org/ and a gift of HLAA membership at — https://17291.thankyou4caring.org/sslpage.aspx?pid=410
Our memberships are dual memberships in both the HLAA and the HLAA Sarasota/Manatee Chapter. Veterans are free!
Join now and get the HLAA "Hearing Loss Magazine". Keep up with the technology!
The cost is $35 for an Individual membership, $45 for a Couple.
Among the many functions of HLAA National is the lobbying for people with hearing loss to have equal access in public venues. Note—your renewal notices will come from HLAA in Bethesda–if you do not get one, please let us know.
By the way, the free Players Theatre tickets (looped so you hear and understand every word) and the $10 Van Wezel tickets (one or two events in a looped theater) are worth the membership fee.
NEW PERK!!! Also members receive 20% off the assistive and communication products sold by Harris Communications— https://www.harriscomm.com/
If you have any questions on Membership please feel free to contact Anne Taylor at firstname.lastname@example.com. Membership Applications can be found at the Chapter Website, http://hlas.org.
Welcome to the Hearing Loss Association of America – Sarasota/Manatee Chapter (HLAA-Sarasota/Manatee), the leading organization for people with hearing loss in Sarasota and Manatee counties.
As a member of HLAA-Sarasota/Manatee you are part of an organization with a mission to provide information, support and advocacy to people with hearing loss. Through our advocacy work at the federal level (HLAA), we represent 48 million people with hearing loss in the United States.
As a member of HLAA-Sarasota/Manatee, you will also be supporting our on-going mission to provide greater hearing access in theatres, community venues, houses of worship and throughout the community as we represent the over 145,000 people with hearing loss in Sarasota and Manatee Counties. One out of five people in the two counties has a hearing loss, so you are not alone.
All our monthly meetings also provide Hearing Loop and CART (Captions) support so you will not miss a word from our expert speakers.
Please go to Membership Online! link to fill out and pay online.
For a HLAA Professional Membership application, Click here