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This view shows enzymes only for those organisms listed below, in the list of taxa known to possess the pathway. If an enzyme name is shown in bold, there is experimental evidence for this enzymatic activity.
|Biosynthesis → Amino Acids Biosynthesis → Proteinogenic Amino Acids Biosynthesis → L-methionine Biosynthesis → L-methionine Salvage → S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
|Degradation/Utilization/Assimilation → Nucleosides and Nucleotides Degradation → S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation
Some taxa known to possess this pathway include : Arabidopsis thaliana col, Bacillus subtilis, Bacillus subtilis subtilis 168, Homo sapiens, Klebsiella oxytoca, Klebsiella pneumoniae, Lupinus luteus, Mus musculus, Oryza sativa, Solanum lycopersicum
Expected Taxonomic Range:
General Background
The biosynthesis of several important metabolites involves the consumption of L-methionine through the utilization of S-adenosyl-L-methionine (SAM), in a reaction that releases S-methyl-5'-thioadenosine (MTA). These metabilites include polyamines (see spermine biosynthesis, spermidine biosynthesis I and aminopropylcadaverine biosynthesis), ethylene (see ethylene biosynthesis I (plants)), and bacterial auto-inducers (see autoinducer AI-1 biosynthesis).
MTA is a strong inhibitor of polyamine biosynthesis and transmethylation reactions, and its concentration is tightly regulated through the methionine salvage cycle, where MTA is recycled through a series of reactions back to L-methionine.
The methionine salvage pathway is present with some variations in all types of organisms [Albers09]. It has been partially characterized from a number of organisms, including bacteria [Myers93, Wray95, Cornell96a, Dai99a, Dai01], plants [Baur72, Murr75, Kushad83, Miyazaki87a], yeast [Marchitto85], protozoal parasites [Sufrin95, Berger01a] and rat [Backlund81, Backlund82, Wray95]. The pathway was best studied in the Gram-negative bacterium Klebsiella pneumoniae.
While most of the pathway is conserved among all organisms, several variants exist that differ in the initial steps of the pathway, between S-methyl-5'-thioadenosine (MTA) and 5-methylthioribulose 1-phosphate (MTRP). These variants, describing bacteria and plants, higher eukaryotes, and protozoa, are described by several pathways under S-methyl-5'-thioadenosine Degradation. This metabolic differences in the early steps of the methionine salvage pathway are being exploited for developing new drugs targeted against pathogenic microorganisms that utilize the MTA nucleosidase-MTR kinase pathway [Riscoe88, Gianotti90, Tower91].
About This Pathway
This pathway describes the conserved part of the methionine salvage cycle, starting with S-methyl-5-thio-α-D-ribose 1-phosphate. In 6 steps, comprising an isomerase, a dehydratase, an enolase, a phosphatase, an oxygenase, and a transaminase, S-methyl-5-thio-α-D-ribose 1-phosphate is converted to L-methionine [Albers09]. The last enzyme, a glutamine-dependent transaminase, produces the byproduct 2-oxoglutaramate, which is believed to be toxic. Thus an additional enzyme, an ω-amidase that converts the latter to 2-oxoglutarate, is also considered a part of the pathway [Ellens14].
A few notes of interest about the enzymes of this pathway
At least in some strains, such as Bacillus subtilis, EC 126.96.36.199, 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, is a member of the RubisCO protein family [Imker07].
The reaction catalyzed by EC 126.96.36.199, acireductone dioxygenase [iron(II)-requiring], can occur non-enzymatically in the presence of air [Wray95]. It is yet unknown whether the non-enzymatic reaction occurs in vivo [Wray95].
If the enzyme that usually catalyzes EC 18.104.22.168, acireductone dioxygenase [iron(II)-requiring] binds a Ni2+ instead of Fe2+, it catalyzes a different reaction ( EC 220.127.116.11, acireductone dioxygenase (Ni2+-requiring)), forming a shunt of the methionine salvage pathway (see 3-methylthiopropanoate biosynthesis) [Dai01, Dai99a, Wray95]. The purpose of this off-pathway reaction is yet unknown; it may, however, provide a mechanism for regulating L-methionine levels in vivo [Dai01].
In some organisms the reactions catalyzed by EC 22.214.171.124, 2,3-diketo-5-methylthiopentyl-1-phosphate enolase and EC 22.214.171.124, 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase are catalyzed by a single enzyme, EC 220.127.116.11, acireductone synthase (MtnC).
Superpathways: L-methionine salvage cycle I (bacteria and plants), L-methionine salvage cycle II (plants), L-methionine salvage cycle III
Variants: S-methyl-5-thio-α-D-ribose 1-phosphate degradation II
Created 16-Mar-2011 by Caspi R, SRI International
Revised 01-Jul-2014 by Caspi R, SRI International
Albers09: Albers E (2009). "Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine." IUBMB Life 61(12);1132-42. PMID: 19946895
Backlund81: Backlund PS, Smith RA (1981). "Methionine synthesis from 5'-methylthioadenosine in rat liver." J Biol Chem 1981;256(4);1533-5. PMID: 7007366
Backlund82: Backlund PS, Chang CP, Smith RA (1982). "Identification of 2-keto-4-methylthiobutyrate as an intermediate compound in methionine synthesis from 5'-methylthioadenosine." J Biol Chem 1982;257(8);4196-202. PMID: 7068632
Baur72: Baur A.H., Yang S.F. "Methionine metabolism in apple tissue in relation to ethylene biosynthesis." Phytochemistry (1972) 11 : 3207-3214.
Berger01a: Berger LC, Wilson J, Wood P, Berger BJ (2001). "Methionine regeneration and aspartate aminotransferase in parasitic protozoa." J Bacteriol 2001;183(15);4421-34. PMID: 11443076
Cornell96a: Cornell KA, Winter RW, Tower PA, Riscoe MK (1996). "Affinity purification of 5-methylthioribose kinase and 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Klebsiella pneumoniae." Biochem J 1996;317 ( Pt 1);285-90. PMID: 8694776
Dai01: Dai Y, Pochapsky TC, Abeles RH (2001). "Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae." Biochemistry 2001;40(21);6379-87. PMID: 11371200
Dai99a: Dai Y, Wensink PC, Abeles RH (1999). "One protein, two enzymes." J Biol Chem 1999;274(3);1193-5. PMID: 9880484
Ellens14: Ellens KW, Richardson LG, Frelin O, Collins J, Ribeiro CL, Hsieh YF, Mullen RT, Hanson AD (2014). "Evidence that glutamine transaminase and omega-amidase potentially act in tandem to close the methionine salvage cycle in bacteria and plants." Phytochemistry. PMID: 24837359
Gianotti90: Gianotti AJ, Tower PA, Sheley JH, Conte PA, Spiro C, Ferro AJ, Fitchen JH, Riscoe MK (1990). "Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase." J Biol Chem 1990;265(2);831-7. PMID: 2153115
Imker07: Imker HJ, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA (2007). "Mechanistic diversity in the RuBisCO superfamily: the "enolase" in the methionine salvage pathway in Geobacillus kaustophilus." Biochemistry 46(13);4077-89. PMID: 17352497
Kushad83: Kushad M.M., Richardson D.G., Ferro A.J. "Intermediates in the recycling of 5-methylthioribose to methionine in fruits." Plant Physiol. (1983) 73 : 257-261.
Marchitto85: Marchitto KS, Ferro AJ (1985). "The metabolism of 5'-methylthioadenosine and 5-methylthioribose 1-phosphate in Saccharomyces cerevisiae." J Gen Microbiol 1985;131 ( Pt 9);2153-64. PMID: 3906034
Miyazaki87a: Miyazaki J.H., Yang S.F. "The methionine salvage pathway in relation to ethylene and polyamine biosynthesis." Physiol. Plantarum (1987) 69 : 366-370.
Murr75: Murr D.P., Yang S.F. "Conversion of 5'-methylthioadenosine to methionine by apple tissue." Phytochemistry (1975) 14 : 1291-1292.
Myers93: Myers RW, Wray JW, Fish S, Abeles RH (1993). "Purification and characterization of an enzyme involved in oxidative carbon-carbon bond cleavage reactions in the methionine salvage pathway of Klebsiella pneumoniae." J Biol Chem 1993;268(33);24785-91. PMID: 8227039
Riscoe88: Riscoe MK, Ferro AJ, Fitchen JH (1988). "Analogs of 5-methylthioribose, a novel class of antiprotozoal agents." Antimicrob Agents Chemother 1988;32(12);1904-6. PMID: 2854458
Sufrin95: Sufrin JR, Meshnick SR, Spiess AJ, Garofalo-Hannan J, Pan XQ, Bacchi CJ (1995). "Methionine recycling pathways and antimalarial drug design." Antimicrob Agents Chemother 1995;39(11);2511-5. PMID: 8585735
Tower91: Tower PA, Johnson LL, Ferro AJ, Fitchen JH, Riscoe MK (1991). "Synergistic activity of 5-trifluoromethylthioribose and inhibitors of methionine synthesis against Klebsiella pneumoniae." Antimicrob Agents Chemother 1991;35(8);1557-61. PMID: 1929327
Wray95: Wray JW, Abeles RH (1995). "The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases." J Biol Chem 1995;270(7);3147-53. PMID: 7852397
AlMjeni02: Al-Mjeni F, Ju T, Pochapsky TC, Maroney MJ (2002). "XAS investigation of the structure and function of Ni in acireductone dioxygenase." Biochemistry 41(21);6761-9. PMID: 12022880
Ambler87: Ambler RP, Auffret AD, Clarke PH (1987). "The amino acid sequence of the aliphatic amidase from Pseudomonas aeruginosa." FEBS Lett 215(2);285-90. PMID: 3108029
Anastasatu: Anastasatu C, Bercea O "[30 years of activity at the Institute of Phthisiology]." Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol 28(2);65-6. PMID: 227040
Ashida03: Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A (2003). "A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO." Science 302(5643);286-90. PMID: 14551435
Ashida08: Ashida H, Saito Y, Kojima C, Yokota A (2008). "Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis." Biosci Biotechnol Biochem 72(4);959-67. PMID: 18391471
Balakrishnan93: Balakrishnan R, Frohlich M, Rahaim PT, Backman K, Yocum RR (1993). "Appendix. Cloning and sequence of the gene encoding enzyme E-1 from the methionine salvage pathway of Klebsiella oxytoca." J Biol Chem 1993;268(33);24792-5. PMID: 8227040
Berger03: Berger BJ, English S, Chan G, Knodel MH (2003). "Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis." J Bacteriol 185(8);2418-31. PMID: 12670965
Chae11: Chae, Lee (2011). "The functional annotation of protein sequences was performed by the in-house Ensemble Enzyme Prediction Pipeline (E2P2, version 1.0). E2P2 systematically integrates results from three molecular function annotation algorithms using an ensemble classification scheme. For a given genome, all protein sequences are submitted as individual queries against the base-level annotation methods. The individual methods rely on homology transfer to annotate protein sequences, using single sequence (BLAST, E-value cutoff <= 1e-30, subset of SwissProt 15.3) and multiple sequence (Priam, November 2010; CatFam, version 2.0, 1% FDR profile library) models of enzymatic functions. The base-level predictions are then integrated into a final set of annotations using an average weighted integration algorithm, where the weight of each prediction from each individual method was determined via a 0.632 bootstrap process over 1000 rounds of testing. The training and testing data for E2P2 and the BLAST reference database were drawn from protein sequences with experimental support of existence, compiled from SwissProt release 15.3."
Cobzaru11: Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R (2011). "Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria." Res Microbiol 162(3);285-91. PMID: 21288482
Erb12: Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA (2012). "A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis." Nat Chem Biol 8(11);926-32. PMID: 23042035
Fouts08: Fouts DE, Tyler HL, DeBoy RT, Daugherty S, Ren Q, Badger JH, Durkin AS, Huot H, Shrivastava S, Kothari S, Dodson RJ, Mohamoud Y, Khouri H, Roesch LF, Krogfelt KA, Struve C, Triplett EW, Methe BA (2008). "Complete genome sequence of the N2-fixing broad host range endophyte Klebsiella pneumoniae 342 and virulence predictions verified in mice." PLoS Genet 4(7);e1000141. PMID: 18654632
Furfine88: Furfine ES, Abeles RH (1988). "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae." J Biol Chem 1988;263(20);9598-606. PMID: 2838472
Gaudet10: Gaudet P, Livstone M, Thomas P (2010). "Annotation inferences using phylogenetic trees." PMID: 19578431
GOA01a: GOA, DDB, FB, MGI, ZFIN (2001). "Gene Ontology annotation through association of InterPro records with GO terms."
GOA06: GOA, SIB (2006). "Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins."
Han04: Han Q, Li J (2004). "pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I." Eur J Biochem 271(23-24);4804-14. PMID: 15606768
Han09: Han Q, Robinson H, Cai T, Tagle DA, Li J (2009). "Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K." J Med Chem 52(9);2786-93. PMID: 19338303
Hersh71a: Hersh LB (1971). "Rat liver omega-amidase. Purification and properties." Biochemistry 10(15);2884-91. PMID: 5114531
Jaisson09: Jaisson S, Veiga-da-Cunha M, Van Schaftingen E (2009). "Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2." Biochimie 91(9);1066-71. PMID: 19596042
Kunst97: Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Codani JJ, Connerton IF, Danchin A (1997). "The complete genome sequence of the gram-positive bacterium Bacillus subtilis." Nature 390(6657);249-56. PMID: 9384377
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News: Ricky Online Behavior Is Back Door to Cybercrime
sdy284 - October 4, 2006 08:57AM in
- "Social-networking sites could give hackers a backdoor into corporate IT platforms and databases, putting businesses at risk for malicious cyber attacks as more adults access these sites from computers at work., according to a study released Wednesday by CA (the former Computer Associates) and the National Cyber Security Alliance (NCSA). "We are already seeing hackers take advantage of community Web sites," Ron Texeria, executive director of NCSA, said in a statement. "
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I've recently started taking pregnacare as I don't think I was getting enough vitamins before. So far i've been taking it for a week and have been fine, not so nauseous and able to eat anything at last! Has anyone else taken this throughout their pregnancy as my midwife said to stop taking folic acid once my 3 months are up but pregnacare says safe to take throughout? I don't know if I should continue with it or not, ill ask my midwife when i see her next but could do with some feedback?
One of my work collegues has just had her baby last month and she was taking pregnacare right up til the birth, she swore by it as the best supplement she'd found. I'm taking it myself, the + one with the little oil capsules as well as the pill. I'm far from an expert but I think you don't need the folic acid after 3 months but pregnacare is giving you more than just folic acid so it's doing good for all stages.
Thanks for that, ive been feeling a lot better since taking it so i will continue with it, Im only taking the pills for a week but can tell the difference already!
Hey, Im 17 wks tomorrow and have been taking pregnacare everyday since I found out and even before for about a month and a half as it also says its good for conception. This will be our first so I have nothing to compare it to but I swear it is the reason I never had any sickness as it contains B10, which if Ive got the right one, is apparently supposed to help in that dept.
I know folic acid isnt needed after the 12th week, but as pregnacare contains so many other good vitimins and folic acid doesnt cause any harm after the 12th week, I plan to take it for the full pregnancy. You can even take it whilst breastfeeding so Im thinking I might do that too, or switch to the specific pregnacare breastfeeding one.
I've been taking Pregnacare Original since I found out, I'm now over 14 weeks and finding its really helpful. I'm also taking Floradix which is a natural supplement to boost the iron levels in the blood, my midwife recommended it to me because I've been found to have low iron levels in the past. This is definitely increasing my energy levels. The only thing I would say about Pregnacare is DEFINITELY don't have it on an empty stomach, always take it after you've eaten something substantial. There have been a few occasions now where I've taken it a couple of hours after I've eaten and I've been sick. I know it says on the packet to take it on a full stomach but this time, it really means it haha!! I've not really had morning sickness in the sense that I've only ever felt sick and I'm rarely actually sick, but Pregnacare did make me vomit if I didn't make sure I'd eaten enough beforehand. I suppose its different for everyone but just wanted to make sure!
Also, I would agree that taking Pregnacare right up until birth is absolutely fine, it contains all the vitamins and minerals your baby needs to stay healthy and it helps to boost you too :) I'm gonna switch to the breastfeeding supplement with Omega 3 once my baby's born, but for now I'm happy with what I'm taking.
I'm 28+4 today and I've taken Pregnacare Plus throughout the pregnancy. My MW says it's ok to take, I had bloods done on Monday and my doc is really pleased with the results, HB was 14.5. I'm allergic to about half of fruit and veg and decided to make sure bubs gets all the help he/she can. I plan to take the breastfeeding Pregnacare once bubs is born, just have to find the equipvalent in here as I live in Germany now and am down to my last supply of Pregnacare....
Mari x
Hi I took pregnacare throughout my pregnancy and my lo is now a year old! I continued taking it throughout breastfeeding too and have only just stopped taking it recently! She is really healthy and has a good immune system, has only had one cold since birth as oppossed to others her age had loads of colds and bugs and stuff so I would recommend it... and breastfeeding!! xx good luck to you all. xx
hiya i'm 25 weeks and took folic acid for the first month to month and a half then switched to pregnacare and haven't stopped taking it since and i've only had morning sickness a couple of times my midwife knows i'm still taking it and hasn't advised me to stop also it does say on the box that it can be taken throughout the whole pregnancy and if that was wrong then i'm sure trading standards would have made them change hope everything goes well for you x
I took the pregnacare conception while we were trying, and when i found out i was preggers, i carried on taking it until 10 weeks (and when the pack finished), then moved onto the pregnacare original which still has the folic acid, but had other vitamins and nutriants required for pregnancy and can even be taken after bubba is born and while you are breast-feeding.
I took it right through my pregnancy. I actually took the Pregnacare Plus Omega as I don't eat fish. I had a very very healthy pregnancy and my LO was perfectly healthy when she was born (and now!) x
I didnt find out I was pregnant til 3 months, so hadn't taken any folic acid :( The doc said not to worry, and that if you have a healthy diet you will get enough. It's just that it doesn't store in the body like other stuff can so it's good to have the extra when TTC and at first - but it certainly doesn't hurt after and carries on helping with neurological development. I'm not religious about it but I try to take the pregnancare and omega oils after dinner every day when I remember :)


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Individual Game Tickets
All Women's Basketball Games take place in The Roof at the Case Center Gymnasium located at 285 Babcock Street unless otherwise noted.
|Wed., Mar. 2
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To purchase your individual tickets to games:
- Simply click on the TICKETS icon below for the games to purchase online.
- Call Ticketmaster at 1-800-745-3000, or visit any Ticketmaster outlet or the Agganis Arena Ticket office located at 925 Commonwealth Avenue, Monday through Friday, 10am-5pm. The Ticket Office at Walter Brown Arena located at 285 Babcock Street, opens one hours before each game and tickets will be available at the Windows.
- Individual game tickets for Boston University faculty and staff are available at the Agganis Arena/Walter Brown Ticket office for $5.00, subject to availability. Boston University students without a Sports Pass can also purchase individual game tickets at the Agganis Arena/Walter Brown Ticket office for $5.00, subject to availability.
- GROUP TICKETS: Group orders of 10 plus may be placed now. We invite you to join us in experiencing exciting Terrier Women's Basketball action with your friends, colleagues, teammates, and family. Please email the Ticket Office or call 617.353.GOBU (4628).


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Catholics in Indonesia, 1808-1942: A Documented History, Volumen 2
KITLV Press, 2003 - 634 páginas
Indigenous Indonesian Catholics increased in number from 27,000 to nearly 550,000 between 1902 and 1942. At first scattered only through Minahasa, the Kai islands and Flores, after four decades Catholic centres were established in most of the archipelago, and there was even a small but well-educated and vocal minority in Central Java. It is this formative period in the growth of Catholicism in Indonesia that Steenbrink describes in detail. Catholics never constituted more than three per cent of the Indonesian population, one-third of all Christians. Steenbrink examines the rivalry of this minority with Protestants and their missionary activities, as well as the race with Islam in many parts of the outer islands, which had come under Dutch rule in the early twentieth century. This comprehensive work includes extensive details on the different European missionary orders and missionaries active at this time.
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Catholics in Indonesia, 1808-1942: A Documented History. Volume 2 ..., Volumen 2
Karel Steenbrink
Vista previa restringida - 2007


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Massa got hit by the spring, Rossi broke the leg...
Sometimes when you learn that you are not immortal, you lose the edge.


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A biotech company reports that an experimental treatment elongated its CEO's telomeres.
Do Mine Ears Deceive Me?
September 1, 2015|
A new approach shows how both honesty and deception are stable features of noisy communication.
September 1, 2015|
A new approach shows how both honesty and deception are stable features of noisy communication.
August 1, 2015|
In Chapter 4, "The quantum beat," authors Johnjoe McFadden and Jim Al-Khalili rethink Newton's apple from a quantum-biological perspective.
June 1, 2015|
In the prologue, "Lemurs and the Delights of Fieldwork," author Ian Tattersall shares the paleoanthropological lessons he learned from studying non-human primates in Madagascar.
June 1, 2015|
As the science of paleoanthropology developed, human evolutionary trees changed as much as the minds that constructed them.
May 1, 2015|
A close cooperation between science, politics, and economics has helped to control one of history's most destructive epidemics.
April 1, 2015|
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.
April 1, 2015|
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
December 1, 2014|
In Chapter 7, "Green Evolution, Green Revolution," author John Archibald describes how endosymbiosis helped color the Earth in a verdant hue.
November 1, 2014|
In Chapter 1, "Fossils and War," author J.G.M. "Hans" Thewissen describes the difficulties of conducting field research in a conflict zone.
November 1, 2014|
The history of cetaceans can serve as a model for both evolutionary dynamics and interdisciplinary collaboration.


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Basic Facts About Alzheimer's Disease
Alzheimer's Disease is a degenerative brain disorder in which neurons, the specialized cells of the brain that process information,
stop functioning properly. The disease is named after Dr. Alois Alzheimer, a German doctor who first described the disease
in 1906 after performing an autopsy on the brain of a woman who had experienced severe mental problems in the years before her death.
Examination of her brain revealed the "neuritic plaques" and "neurofibrillary tangles" that are now hallmarks of the disease.
The incidence of Alzheimer's disease rises sharply with age. While only 2 to 5% of persons aged 65 show signs of Alzheimer's, 25 to 50% of persons aged 85 show symptoms of the disease. The average duration of the disease is about 7 to 10 years.
There are currently about 4.5 million U.S. citizens living with Alzheimer's disease. That number is expected to grow to over 14 million by the year 2050.
Approximately 30,000 to 50,000 people in the U.S. die from Alzheimer's disease each year.
The first signs of Alzheimer's disease are usually problems with memory. These problems often begin with relatively minor instances of forgetfulness, which can be a normal part of healthy aging. But in individuals with Alzheimer's disease they become increasingly frequent and severe, eventually interfering with normal activities of daily living.
Trouble signs include consistently forgetting to lock doors, turn off appliances, or take one's medication; repeatedly asking the same question or telling the same story; difficulty finding common words; and getting lost in familiar environments. Other early warning signs include poor judgment (e.g., leaving a child unattended) and changes in personal care (not bathing) or personality (mood swings or inappropriate bouts of anger, fear, or paranoia).
Next to show up are persistent impairments in attention and short-term/working memory. Attention problems often show up as an inability to concentrate or multi-task (do two or more things at once). Working-memory problems show up as an inability to hold information in mind for brief periods of time in order to accomplish an intended task. Problems with attention and working-memory lead to impairments in learning new information, as these two processes are critical in getting information into and out of long-term memory.
As the disease progresses, memory and attention problems get worse such that the person begins to forget significant life events, fails to recognize familiar people or objects, and has trouble performing well-learned tasks. Visual-spatial deficits may also occur. Eventually, the person becomes disoriented, unable to remember the day, the year, or even where they are. Communication becomes difficult and the person may become 'disinhibited', behaving inappropriately or having emotional, sometimes violent, outbursts. In the final stages of the disease, the person loses the ability to control their body, becoming incontinent and unable to feed or move themselves.
A diagnosis of Alzheimer's Disease is primarily made by clinical observation along with tests of memory and cognitive function. These are usually coupled with physical (blood and urine) tests designed to rule out alternative diagnoses. Along this line it is important to note that Alzheimer's Disease, although the most common, is only one of a spectrum of age-related conditions that can cause dementia. These other conditions include Vascular (multi-infarct) Dementia, Frontotemporal Dementia (Pick's Disease), and Lewy Body Dementia. Recently, neuroimaging techniques--including MRI scans which reveal brain stucture, and PET & SPECT scans which reveal brain activity and chemistry--are being used in the diagnosis of Alzheimer's and related dementias.
The primary neurological signs of Alzheimer's Disease are, first, the accumulation of a protein known as beta amyloid within the brain but outside of the nerve cells; clumps of beta-amyloid are called senile or neuritic plaques, and these plaques are thought to interfere with the communication between neurons. The second sign is the accumulation of abnormal filaments inside of neurons called neurofibrillary tangles which are believed to interfere with the normal operation of the cell; the protein making up these filaments is known as tau. There are also changes in the brains' neurochemistry, including abnormal changes in the levels of the brain's key neurotransmitters, as well as increased inflammation. Together, these changes lead to widespread atrophy of neurons, loss of dendritic and axonal connections, and neuronal death. At a more macroscopic level, the brain shows widespread loss of tissue, primarily in the temporal, parietal, and frontal lobes, along with enlargement of the ventricles.
The exact cause of Alzheimer's disease is unknown. Many scientists believe that multiple factors may be involved. Age is the most common risk factor, as the incidence of Alzheimer's rises significantly after age 65. Family history is also a risk factor, which suggests that genetic factors are involved. Presence of a specific form of the gene known as apolipoprotein E (ApoE) is associated with increased risk for Alzheimer's disease. Other risk factors include high blood pressure and high levels of cholesterol.
There is no known cure for Alzheimer's Disease although medications, cognitive stimulation, social support, and lifestyle changes have been shown to help with some symptoms.
Education, aerobic exercise, a healthy diet, and living an active, cognitively-challenging lifestyle are all associated with a reduced risk of Alzheimer's Disease.
To view a related fact sheet on Aging, Memory, & Cognition, click here.
To view a related fact sheet on Brain Fitness & Cognitive Training, click here.
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text:
It might come as a surprise, but each year, injuries and violence account for more than 5 million deaths worldwide—causing as many deaths as HIV, malaria, and tuberculosis combined.
For young people ages 15–29, road traffic injuries, suicides, homicides, drownings, burns, war injuries, poisonings, and falls are among the leading causes of death.
"Injuries are a major global public health problem that has largely been overlooked," writes Etienne Krug, M.D., of the World Health Organization (WHO). "Many countries do not have the experts needed to address the issues."
Health professionals around the world are using a new online course developed by EDC called TEACH-VIP E-Learning to build their skills in preventing injuries and violence.
"Knowledge about how to prevent injuries and violence is vital," says EDC's Carmen Aldinger, who directed the development of the course. "This online course fills an important need."
Based on a comprehensive curriculum created by WHO, the course is designed for public health professionals; health care providers; staff of public health ministries and nongovernmental organizations; and students and faculty at schools of medicine, nursing, and public health.
Originally published on April 14, 2010


text:
N.O.R.E. ft. Swizz Beatz, Busta Rhymes,Talib Kweli, Cassidy & Red Cafe - Set It Off (Remix)
Not since Craig Mack's Flava In Ya Ear has any rapper found a way to gather several of the East Coast's best MCs on a remix—until now. Give credit to N.O.R.E. who reached that milestone on the remix to his underground club banger, Set It Off. Swizz Beatz' production and hook remain intact, and N.O.R.E. spits a hot new guest verse, even bringing up T.I.'s recent federal weapons charges. However, the new guest rappers steal the show as Busta Rhymes, Talib Kweli, Cassidy, & Red Café illustrate how an East Coast club banger oughta be handled. While this remix certainly deserves plenty of spins, only time will tell if it will be remembered a decade from now like Flava In Ya Ear.
N.O.R.E Swizz Beatz Talib Kweli Cassidy Red Cafe


text:
Good piece of code
Thank You
Kamal Chauhan
Good piece of code
Thank You
Kamal Chauhan
These tutorials are good and practical. I apprecia
These tutorials are good and practical. I appreciate ur work..
Russel Fyodor
Determining if two Filename paths refer to the same file.
to determine that the file name
refers to the same file or not. What you need to do is to
create two File object and pass the file name in the constructor of both... Determining if two Filename paths refer to the same
Java file get name
Java file get name
In this section, you will learn how to get the name of the file.
Description of code:
You can see in the given example, we have created... the name of the file.
Here is the code:
import java.io.*;
public class
Java File - Java Beginners
Java File Hi Friend,
Thank you for the support I got previously...
Anyone please send me the Java Code for scanning a directory and print... send me the code for the same. Thanks in advance.
Hash value is not same - Java Beginners
2003 files is not same as the hash value of Excel 2007 file.
What might be the problem.
Thank You,
Umesh Kilkile Hi Friend,
Please...Hash value is not same Hi,
I've two Excel files with same data
How to design a piece of steel pipe
help you to learn how to
design a piece of the steel pipe.
New File: Create a new file with any size as you
Draw a Pipe: Choose "E52247"... Overlay, Inner Shadow and use same settings.
You will get it.
view jsp file (reference file). is the way of coding good ?
view jsp file (reference file). is the way of coding good ? <%@ page language="java" contentType="text/html; charset=ISO-8859-1"
pageEncoding...;The given code retrieves the data from the database and display it in html tables
Java Get File Name
Java Get File Name
In this section, you will study how to obtain the name of file.
In order to get the file name, we have provided the path of file 'Hello.txt
java code to upload and download a file - Java Beginners
java code to upload and download a file Is their any java code... store two different files with same path name but content different,
ex,in mails... user sends with same name a.doc (but different content) to y,he has to download
Executale File - Java Beginners
the instruction.. Good Luck i don;t know how to create the exe file for java  ... for java but you can create an executable jar file .create a MF file...Executale File Plz tell me how to convert java file into .exe file
How to design a piece of the rope
that will help you
about this effect so follow this example.
New File... Selection: Take a new file with same size
of the selection then paste.
Change... How to design a piece of the rope
Use a simple technique


text:
by Jim Tankersley
They said the first was an outlier. The second, a fluke. But after losing their third seat this year in a special election, House Republicans faced the possibility on Wednesday that if they don't repair their image with voters, they could be in for another rough November.
A Democratic pick-up streak that started with Rep. Bill Foster's upset victory in the March election to replace former House Speaker Dennis Hastert (R-Ill.) crested Tuesday night, when Democrat Travis Childers won a solidly Republican open seat in Mississippi.
The GOP spent one-fifth of its available national party cash for House races on the Mississippi seat. Vice President Dick Cheney campaigned there. President George W. Bush and presumptive Republican presidential nominee John McCain pitched in with automated phone calls. Their candidate lost anyway. Meanwhile, reeling House Republicans unveiled a new slogan this week--"Change you deserve" --only to watch Democrats gleefully note that it is already used to market an antidepressant.
Several House Republicans say the losses reveal a voter disconnect with their party, rooted in dissatisfaction with Bush, which GOP candidates will have to repair district-by-district this fall. Some, including McCain and several members of the Illinois congressional delegation, appear to believe that to "re-brand" the Republican Party, they must first distance themselves from it.
Read the full story in today's Chicago Tribune.
"What we've got right now is a deficiency in our message and a loss of confidence by the American people that we will do what we say we are going to do," Rep. Tom Cole (R-Okla.), chairman of the National Republican Congressional Committee, said in a conference call with reporters.
Freshman Rep. Peter Roskam (R-Ill.) likened the climate to 2006, when Democrats surged to control of the House and Senate. "There's a lot of dissatisfaction with the direction of the country," he said. "No incumbent should underestimate the attitude of the American people, Republican or Democrat."
The parties share power in Washington. Polls show Bush and Congress faring dismally in voter approval ratings, driven by anxieties from a slowing economy and continued dissatisfaction with the Iraq War. But politicians and analysts say it appears, at least at this point in the campaign, that voter frustration is hurting Republicans more.
Chalk up part of that to recruiting, analysts say. The three House seats to flip to Democratic this spring all lie in districts Bush carried in 2004. The Democrats who won them all ran as moderate agents of change who support troop withdrawal from Iraq.
Foster opposed his own party's budget proposal on Wednesday and said in a press release it "unfairly places a hefty tax burden on the backs of hard-working middle-class families." Childers and Don Cazayoux, the Democrat who won a formerly GOP seat in Louisiana this month, both favor gun rights and oppose legalized abortion--making them "Republicans in all but title," Cole said.
Stuart Rothenberg, editor and publisher of the non-partisan Rothenberg Political Report, said Republicans need to run better candidates to better fit their districts. "Democrats have learned how to win in conservative districts by running conservative candidates," he said.
Democrats suggest something larger as well: a link in voters' minds between GOP candidates, economic struggle and an unpopular war.
"After all their setbacks, I realize the Bush Republicans are depressed these days," Rep. Rahm Emanuel (D-Ill.), the House Democratic Caucus chairman, said in a taunting press release, "but before they turn to medication, they ought to join us in our effort to bring real change."
House Republicans say they expect a chilly electoral climate this fall. To weather it, several touted their abilities to work across--or transcend--party lines. McCain, in events across the Pacific Northwest this week, took a similar approach to the presidential race, emphasizing his break from the Bush administration on global warming.
"The critical challenge before both parties is to articulate a 21st Century agenda," said Rep. Mark Kirk (R-Ill.), who faces a high-profile challenge from Democrat Dan Seals in a district that voted for Sen. John Kerry (D-Mass.) in the 2004 election.
After Tuesday's GOP loss, Kirk said several Republicans began inquiring about his "suburban agenda," a bipartisan package of health care, environmental, education and other measures. Other Republicans take heart in the belief that voters still share their ideals, including low taxes, strong defense and limited government.
"Our party could have gotten the message out better," said Rep. Judy Biggert (R-Ill.), "but all of us go home and get the message out.... What we have to do is tell people our vision for the future and how we're going to solve our problems."
Several Republicans stressed that November elections don't always follow the results of special elections, which analysts say tend to draw far fewer voters and typically reflect the enthusiasm of the most committed partisans on either side.
Turnout will be higher--and the playing field more level--come November, said David Wasserman, House editor of the non-partisan Cook Political Report in Washington.
"The good news for Republicans," he said, "is that this is rock bottom."
Tribune correspondent Whitney Blair Wyckoff contributed to this report.


text:
An absolute must visit for anyone who wants to learn more about indigenous Taiwanese culture. Taiwanese aboriginals have long suffered under the various administrations in Taiwan, and unemployment and lack of education opportunities are serious problems. This center is trying to stem that tide, but also allow the members of the Bunun tribe to retain their traditions and cultures at the same time.
Located a short drive from Taitung City (by public transport you need to take the Dingdong bus, ask at hotel/train station for up to date information about times) this center is a great little place to spend a few hours. There are daily dancing/singing shows at 11am and 1:30pm that are not to be missed. The staff are really friendly and will give guided tours to show you around and explain everything in English.
Although entry is $150NT, $100 of that money can then be deducted from purchases in the gift shop.


text: December 17, 2010 - Harris, N.Y. - The Catskill Regional Medical Center (CRMC) Radiology Department has been re-accredited for a three-year term in Nuclear Medicine based on a recent survey by the American College of Radiology (ACR). The ACR awards accreditation to hospitals for achieving high practice standards after a peer-review evaluation. The accreditation requires thorough evaluations by board-certified physicians, technologists and medical physicists who are experts in the field. Additionally, the equipment used must meet strict and rigid guidelines as outlined by the ACR. CRMC's Nuclear Medical Service provides a complete range of organ scanning as well as nuclear cardiology imaging. The department utilizes state-of-the-art equipment and provides cardiac imaging under the direction of a team of board-certified cardiologists. CRMC's technologists are board certified and have specialized training for both cardiac and organ scanning. Imaging results are communicated to physicians within 24 hours for routine studies, and same day for nuclear cardiology studies. Studies may be scheduled from 7 a.m. to 8 p.m. Monday through Friday by calling 845-794-3300 ext. 2233.


text:
July 24, 2012
Children enjoy cookies and punch during VBS.
Stories this photo appears in:
"Kids Shine God's Light" at Salem Baptist Church VBS
Salem Baptist Church, California, held its Vacation Bible School July 20-21.
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text:
Accounting down under: time to pack your bags? By Max Williamson
Is there anyone working in finance who doesn't know at least one person who has spent some time in Australia? A secondment to Australia has almost become a rite of passage for many newly qualified UK accountants, most of whom are drawn towards the country on the basis of its excellent work/ life balance, and the almost universal positive feedback of others who have worked there.
Most UK accountants will be aware that salary levels are lower than they are in the UK, but are equally likely to be aware of the fact that the cost of living is also lower.
The full article is available to registered AccountingWEB members only. To read the rest of this article you'll need to login or register.
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Ozzie is not cheap
I have been to Ozzie a number of times, and been pretty much been all around - Sydney, Brisbane, Cairns, Perth, Adelaide, Alice Springs and Tasmania.
From experience the areas that are cheaper than UK are meat, utilities, fuel and house prices. Everything else is more expensive - especially non-meat foods (eg vegetables are 300-400% more than UK) and you do not get the variety that we have come to expect in the UK.
Overall, I would estimate one pays 30-40% more in Australia than in the UK on day-to-day living and with a weakening sterling compared to most other currencies this could grow.
As a fairly frequent visitor to the 'Colonies', perhaps you would be kind enough to specify which town, city or State has a much lower cost of living compared with the UK.
From my experience, on average, it's about the same as here.
I must be going to the wrong locations!


text:
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Shura Cherkassky plays Rachmaninov, Prokofiev, Stravinsky
1 CD / ICA Classics / 2011-05-31Works: Sergey Rachmaninov: Rhapsody on a theme of Paganini; Lachtäubchen (Behr) "Polka de W.R."; Sergey Prokofiev: Sonata for Piano no 7 in B flat major, Op. 83; Igor Stravinsky: Movements (3) from P&e...
Performers: Cherkassky, Shura [Piano]
Conductors: Macal, Zdenek
Ensemble: Cologne Radio Symphony Orchestra
Shura Cherkassky (1909 - 1995), one of the greatest piano virtuosos of his time, studied under Josef Hoffman. This CD features a 1970 WDR studio...continue...
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Strauss, Mozart, Stravinsky / Böhm, Cologne RSO
1 CD / Audite / 2007-04-18Works: Richard Strauss: Don Juan, Op. 20; Wolfgang Amadeus Mozart: Symphony no 28 in C major, K 200 (189k); Igor Stravinsky: Firebird Suite
Conductors: ; Böhm, Karl
Ensemble: Cologne Radio Symphony Orchestra; Cologne West German Radio Symphony Orchestra
These recordings of the Strauss' 'Don Juan' and Mozart's 'Symphony No. 28 in C-Major' illustrate Bohm's sovereign command of the music of his "household gods."...continue...
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text:
WatchDog has a new look and a new home
Yo, readers, WatchDog no longer is located here.
It's located here.
C'mon over.
(UPDATE: Comments and RSS feeds not available for blogs on new site yet. Patience.)
Yo, readers, WatchDog no longer is located here.
It's located here.
C'mon over.
(UPDATE: Comments and RSS feeds not available for blogs on new site yet. Patience.)
ESPN retaliated Wednesday against the New York Post for its decision to use still images of Erin Andrews from a surreptitiously obtained videotape, banning Post staffers from its various outlets, including its TV networks and 1050 ESPN Radio.
"In light of the New York Post's decision to run graphic photos of ESPN reporter Erin Andrews, we have decided to stop utilizing Post reporters on any of our outlets," ESPN's senior VP of communications, Chris LaPlaca said.
"Erin was grievously wronged here, and while we understand the Post's decision to cover this as a news story, their running photos obtained in such a fashion went well beyond the boundaries of common decency in the interest of sensationalism. This is not a decision we undertook lightly, but we feel it is an appropriate one."
The Post used images both in print and on its Web site Tuesday from a video the showed Andrews in the nude in a hotel room.
It is not yet clear where the video was shot or who shot it, but Andrews' attorney has promised legal action against any media outlet that publishes the material.
It has not been determined how long the ban on Post employees will remain in place.
Among those most affected are Kevin Kernan and Lenn Robbins, who regularly appear on "First Take" on ESPN2 and Joel Sherman, who appears on 1050 ESPN radio.
Mark Cannizzaro also appears periodically on ESPN outlets, and beat writers from various sports sometimes are interviewed in 1050 or other stations.
LaPlaca stressed that the decision was not directed at the Post employees who have appeared on ESPN outlets, whom he called "innocent bystanders."
A spokesman for NewsCorp, which owns the Post, declined comment. The Post's communication department did not respond to a request for comment.
CBS and Fox used snippets of the video itself Tuesday, which LaPlaca called "beyond the pale."
But he said ESPN could not take the kind of action against those networks it did against the Post because ESPN does not regularly employ those networks' personnel.
Sometime in the next few hours, if the Web gods allow, Newsday will flip the switch on a new-look site with new-look blogs.
Thanks for reading the 5,222 posts on this platform since May 2, 2007.
Time to start over. Please come along!
Photo: AP
ESPN still is on the journalistic sidelines regarding allegations of sexual assault aimed at Ben Roethlisberger.
Why? The network offered some context today to try to further clarify its policy regarding reporting civil suits, which it sometimes does and sometimes doesn't.
Here is what it said were among factors it considered in the Roethlisberger case:
"We're generally very cautious with civil suits that impugn a person's reputation or character."
"We consider the subject's track record/previous history with similar allegations."
"Whether the subject addresses it publicly." Didn't Big Ben's lawyer do that? "In this case, we did not feel Roethlisberger's lawyer's response was enough to warrant our reporting."
"We also consider how such allegation might impact upon the professional performance of the subject/his team."
Example? Roethlisberger is scheduled for a taping of Shaquille O'Neal's reality show. If he doesn't appear, ESPN might revisit the matter based on the possibility it might be "impacting his business decisions and/or his team." An even more obvious example would be if he has to skip part of training camp to be deposed.
ESPN said it recently reported on a planned civil suit against Shannon Brown "because he was playing significant minutes for Lakers in the middle of their championship run in the NBA Playoffs; there was also a police report filed in that case."
In the past, ESPN has passed on reporting civil suits against Michael Vick and Robert Alomar - in the latter case only doing so when Alomar's father discussed it publicly.
What about reporting a suit against Adam (Pacman) Jones?
ESPN did so, it said, "because of his history/past record."
(UPDATE: ESPN.com posted a Big Ben story tonight!)
Photo: AP
ESPN/ABC will be televise college football games again this coming season.
Many of them.
The schedule can be viewed by clicking below and reading the news release fresh off the presses from Bristol.
No mention of Ben Roethlisberger in it. Sorry.
Continue reading "College football to be featured on ESPN again in '09" »
Big-time college athletes in revenue producing sports have been getting cheated economically for more than a century.
Ed O'Bannon wants to help.
It's the illicit video everyone was talking about before that other illicit video turned up.
Images of LeBron getting dunked on evidently have resurfaced!
Now I really need to dig up that video of me dunking on the big guy before a Cavs vs. Knicks game last season.
(UPDATE: The video is up now. Thanks Big Lead for heads up.)
Newspapers are cutting back on costly sports coverage - usually involving travel - and if you think the teams they cover are relieved to have the nattering nabobs of negativism out of their hair . . . you're wrong.
Another interesting day of Erin Andrews coverage from our friends at the Post, this time featuring a front-page story built around her lawyer essentially reiterating what he said in a statement Friday night.
At least Erin is clothed in the picture on the cover, unlike Tuesday.
Unfortunately, I make an appearance in the story, too!
The article quotes something I wrote in Newsday about a brief conversation I had with Ms. Andrews recently.
But instead of crediting it as "Newsday's Neil Best wrote" it reads, "Sports blogger Neil Best said," as if the Post reporter had interviewed me for his story.
Oy. In lieu of an apology, please don't do that to anyone else ever again.
(Full Erin Exploitation disclosure: I just noticed the Newsday.com version of my column includes three separate links to photo galleries of her.)
What with the Erin Andrews video story refusing to die, I was asked to write a brief opinion piece on the subject for the Wednesday newspaper.
So I did.
I spent about three hours Tuesday discussing this with a half-dozen sports media figures - Is there anything else people talk about these days? - and ended up feeling lousier than ever about the whole thing.
Will this latest spasm of media navel-gazing make newspaper Web sites and bloggers less apt to rely on gratuitous pictures of attractive women?
Probably not, but I can't control that.
Will it make this particular blogger less apt to do so?
We shall see, I suppose, but I'd like to think so.
Breaking sports media news here and here from Isles beat scribe Greg Logan: Chris King and Steve Mears have been removed as the team's radio team.
Their replacements? Um, no one. Looking to cut costs, the Isles will simulcast MSG Plus' TV coverage, featuring Howie Rose and Billy Jaffe.
That's going to be a little strange.
In unrelated Islanders media news, Logan and I learned today that C.J. Papa did not have his contract renewed as MSG Plus' reporter for game telecasts.
No word on a replacement yet.
ESPN has decided not to report on the Erin Andrews video story, not out of sympathy for one of its own - although there is plenty of that throughout the company this week - but because of a judgment on news value.
The network's statement:
"We debated it internally and feel that this is the appropriate thing to do. Despite the attention it's gotten, it comes down to a news value judgment. We didn''t see the news value to this story, particularly since it has no bearing on her role as an on-air reporter."
Someone from the Jets just called to offer me an opportunity to buy season tickets for 2009.
It seems I landed on the team's waiting list when I registered for the new stadium PSL auction last fall, and my less-than-a-year of waiting paid off with my big chance to join the Mark Sanchez/Rex Ryan fun at the Meadowlands.
I politely declined. The woman politely asked me why. I said because I just don't want to buy season tickets. She asked why I was on the list. I told her about the PSL auction thing. She asked if I were interested in tickets for 2010. I told her I was not.
She asked whether she could take me off the waiting list. I told her I would like to stay on to continue receiving information about tickets in the future. She said the list mostly is for people actually interested in buying tickets. I said she could remove my name.
ESPN has been curiously silent today in reporting the allegations of sexual assault against Steelers quarterback Ben Roethlisberger.
Newsday and many other outlets have published at least the AP account.
ProFootballTalk.com reported ESPN issued a "do not report" edict on the story to its staff.
Why? Roethlisberger has a warm relationship with ESPN, including business dealings with the network such as appearing at its "upfront" presentation to advertising buyers. Hmm.
It turns out ESPN generally avoids reporting on civil suits against sports figures.
Its statement on this matter: "At this point, we are not reporting the allegations against Ben Roethlisberger because no criminal complaint has been filed. As far as we know, this is a civil lawsuit that Roethlisberger has yet to address publicly."
(UPDATE: Not that ESPN never reports on civil suits, or even plans to file civil suits, as evidenced by this from last month. Hmm.)
(New ESPN ombudsman Don Ohlmeyer is going to have a busy first column in August!)
SI's Jon Heyman announced on Twitter that he has cancelled his subscription to the Post in the wake of it publishing nude pictures of Erin Andrews this morning.
Then SNY's Chris Carlin did the same.
Far be it from me to advocate anyone cancelling a subscription to any newspaper in these troubled times, but the Post's decision has struck a nerve in media land.
(UPDATE: Apparently the Post was not alone in widely disseminating the EA videos. It was done on national TV, too. Oy.)
Will Leitch, one of the founding fathers of sports blogging, has an interesting essay on all of this EA stuff here.
HBO's "Real Sports" debuting Tuesday features an update on a 2003 piece about Jorge Posada's son, Jorge IV, and his struggles with craniosynostosis, a condition that causes malformation of the skull. Now 9 and after many surgeries, Posada's son is doing very well, thank you.
Bill Simmons bids adieu to ESPN The Magazine with a tribute to his father.
Sports Business Journal reports the Arena Football League - including Our Dragons - is considering bankruptcy, is $14 million in debt and might have to delay the start of its 2010 season until June, if there is a 2010 season.
Sorry about slow blogging pace. I'm just marking time until our Web relaunch later this week. Not sure I'm supposed to say exactly when, in case it's delayed.
There will be good things about it (better integration of blog posts and stories/columns), bad things about it (less interesting pictures) and good news/bad news things about it (a registration-based commenting system).
As for the new look, that will be a matter of personal preference. Some of you will love it and others will hate it. I think it looks kinda cool.
Stay tuned, as they say in the newspaper cliche business!
I rode in a train car from Secaucus to E. Rutherford Monday with John Mara, Woody Johnson, Jon Corzine, Damien Woody, Jerricho Cotchery, Rich Seubert and Kareem McKenzie.
Then I wrote a newspaper column about the new rail service to the Meadowlands, a feature 33 years overdue.
Mara called it the most exciting element of the entire new stadium project.
It's unclear how many fans will take advantage of the spur to the Meadowlands - particularly those in far-off Long Island - but the teams hope at least 10,000 per game will.
The idea is to fill some of the tailgating gap with new stuff to do (and eat and buy) near the stadium for those arriving by train.
Also in the column, Jets executive VP Matt Higgins discusses the recent mailing offering anyone on the waiting list a shot at tickets for 2009, and Mara discusses the Giants' decision to cut prices on some club level seats for 2010.
Photo: AP
Generally I avoid criticizing competing New York-area newspapers, given my inherent bias, but Bob's Blitz is right on here in ripping the Post for publishing pictures in print and online of the Erin Andrews "peephole" video. (Which increasingly seems likely to have been shot from an adjoining room or a hidden camera, not a door peephole.)
Aside from being five-day-old news, using the illegally obtained material - on the front page, no less! - is way, way over the line of good taste and good judgment.
This episode gets more depressing by the day.
ESPN announced this morning that in addition to ESPNChicago.com it will add three more city-specific sites in the coming months.
First up: ESPNDallas.com. And in 2010, versions for Los Angeles and, drumroll . . . New York.
Not sure what to say about this frontal assault on the last remaining stronghold of local newspaper sports sections.
Other than this: Bring it on!
Photo: AP
The New York Times recently sold the 96.3 FM frequency long used by WQXR to Univision, which will turn it from classical music to a Spanish language station.
That is relevant here because ESPN Radio was in the mix for that frequency, which it would have used to shift its New York outlet from the unreliable signal at 1050 AM.
For now, ESPN remains stuck there, with hopes a new transmitter in North Bergen, N.J., will improve its signal quality, especially after dark.
Speaking of which, need some help here: Would like to get feedback from WatchDog Nation members around LI - particularly in long-time trouble spot Western Suffolk - about whether the new antenna has helped the 1050 signal, especially after dark.
Attended my first ever women's pro soccer game Sunday - Sky Blue FC vs. the Chicago Red Stars at Rutgers.
Several championship youth soccer teams from Long Island - including Commack, Plainvew and Massapequa - were honored at halftime.
It was a pleasant sports spectating experience that attracted a crowd in excess of 3,000.
Sure, the final score was what you would expect of a soccer match, but at least the lone goal was exciting. Kerri Hanks scored in the 91st minute to win it for Sky Blue.
I long have considered John Noble Wilford's lede in The New York Times of July 21, 1969, to be one of the best in newspaper history.
Rule of thumb: The bigger the event, the simpler the opening paragraph should be.
Forty years later, Mr. Wilford explains how it came about here.
Key excerpt:
I reach for my notebook and try several opening sentences. They must be put on a strict diet. I cross out adjectives. I eliminate clauses that are superfluous and sound too much like heavy music for a movie soundtrack. I begin again: "American astronauts landed." No, too restrictive and chauvinistic; it will be clear soon enough that the astronauts are American and the goal of a decade has been achieved.
I finally get to the irreducible essence in one short sentence: "Men have landed and walked on the moon."
>>Click here to see photos of the Apollo 11 mission
>>Click here to see more coverage of the Summer of 1969
Photo: AP
As a journalist and a baby boomer, I was hugely bummed out by Tom Watson's late collapse Sunday.
As the man himself put it, "It would have been a hell of a story."
But as a human being and fellow Twitterer, I was happy for nice-guy Stewart Cink, who bailed me out with a story when I really needed one at the U.S. Open last month, and whose already impressive half-million-plus Twitter followers is sure to skyrocket now.
As for the coverage on ABC - the last before the entire British Open moves to ESPN next year - the announcers generally were good. Mike Tirico on Watson's gag at 18: "That was a zero confidence putt."
But some of the camera work was mind-boggling. That was mostly not ESPN/ABC's fault. The network has to rely on the BBC's feed, which at times offered strange angles that did not feature an important element of the shot: the ball.
Photo: AP
Fox sent the pilot of Michael Strahan's new sitcom, "Brothers," which premieres Sept. 18, along with strict instructions to use it for "informational" purposes and not for review, since it is not a final version.
I'm a rule-following sort, so I don't want to do anything to upset the Fox public relations people. But I hope they won't mind me saying that while "Seinfeld" it ain't, the show has potential and Strahan is natural and comfortable as a novice actor.
Strahan plays a retired football player who played in two Super Bowls and won one.
Apollo Creed plays his dad, and there even is a "Rocky" reference in the pilot. At least the version of it I saw.
More in September . . .
Photo: Fox
Here is Deadspin's take (complete with an apology) on the Erin Andrews video scandal, prominently featuring a link to my earlier post on this subject.
Hmm. Thanks for the link, but now I feel I should clarify my position:
I certainly wasn't calling out Deadspin in particular. I meant to implicate the entire sports blogosphere (this one included).
Even though the vast majority of us obviously do not endorse what happened, our playful obsession with Ms. Andrews - about which she consistently has been a good sport - surely helped set the stage for this.
What I do endorse is this: That the guy (or gal) who pulled this hidden camera trick spend some quality time in prison.
ESPN's statement: "Erin has been grievously wronged here. Our people and resources are in full support of her as she deals with this abhorrent act."
To this point, the blogosphere's endless fascination with Erin Andrews mostly has been harmless, semi-wholesome fun.
But that changed this week with the surfacing of video somehow taken of Ms. Andrews through a hotel peephole, when she was in a state of extreme undress.
Not cool. The video has been deleted from most sites by now, but not all.
Via PRNewsire:
With respect to recent Internet postings of Erin Andrews, she has authorized her attorney, Marshall B. Grossman of Bingham McCutchen LLP, to issue the following statement:
"While alone in the privacy of her hotel room, Erin Andrews was surreptitiously videotaped without her knowledge or consent. She was the victim of a crime and is taking action to protect herself and help ensure that others are not similarly violated in the future. Although the perpetrator or perpetrators of this criminal act have not yet been identified, when they are identified she intends to bring both civil and criminal charges against them and against anyone who has published the material. We request respect of Erin's privacy at this time, while she and her representatives are working with the authorities."
This week's winner is John H for this response to the post in which I report visiting Dodger Stadium while the Dodgers were in New York:
"Visiting LA without the Dodgers in town? Did Clark W. Griswald plan this family vacation?"
Photo: Getty
I took three books on my L.A. vacation but didn't quite have time to get through all of them.
So my mini-review of Marty Appel's new bio of Thurman Munson will have to wait.
I did read "Miracle Ball," Brian Biegel's account of his quest to solve the biggest mystery in sports memorabilia:
What happened to the ball Bobby Thomson hit to win the 1951 pennant?
Biegel weaves his personal story - and the story of his personal demons - into the tale, which despite some leaps of faith, logic and evidence makes for an oddly compelling read.
Still, even at a modest 227 pages, there are places the spy story feels padded.
This is a worthwhile book, but it likely would have been even better boiled down to the essentials as a magazine article.
"Pull Up a Chair," Curt Smith's bio of Vin Scully, has the same pros and cons as his recent look at Mel Allen's life in "The Voice."
Smith knows as much as anyone about sports broadcasters, and there is plenty of valuable information here.
But his bizarre syntax, tortured historical references and goofy word choices distract from his content.
Lesley Visser, a pioneer both among women in sports journalism and newspaper people who transitioned to TV work, was voted the No. 1 female sportscaster by the American Sportscasters Association.
She was named from a list of 36 finalists that included Andrea Kremer, Robin Roberts, Michele Tafoya and Hannah Storm.
An enjoyably quirky look at the enjoyably quirky SNY baseball booth from the New York Observer.
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Turkey: Israel is playing with fire
News agencies
1. Israel playing with fire says Turkey
Build baby build quickly. These 200 homes will be sold soon. I have few clients who will be interested to invest in this project with very big money.
2. Turkey
Poor turkish people. Someday they will find out the trouble they are in.
paulo ,
3. Only Israel's so-called allies are outraged by E1 building
I haven't heard one condemnation from Russia or China about E1 building. Just goes to show how Israel's so-called friends are in fact the real enemies of the Jewish state.
Jake ,
4. erdogan and gul can go to hell
erdogan and gul can go to hell with their bull. assad showed erdogan to be a big mouth gutless coward who spews venom but cannot back it up. turkish people should thrown out the vermin that is t heir governemtn, t he lying killers of kurds and armenians have no lessons to teach israelis.
5. Free Kurdistan
Gul.. Erdogan.. The day you stop the occupation of Cyprus, the day you stop killing Kurds, the day you will apologize for the Armenian genocide.. that day you can climb up on the stair of moral superiority you put yourself.. Until day day.. keep barking.. or SHUT UP!!!!!
Daniel ,
6. Did Obama Tell them to say this?
I mean seriously
Jeff ,
7. Playing with fire?
Playing with fire is Turkey"s buying Iranian oil disregarding the embargo. Turkey should be tossed from NATO.
Ben S ,
Free world
8. What about Turkish settlers in Kurdistan?
or even teaching Kurdish language in schools? Where are the flotillas?
Salladin ,
Ajubi - Al-Kurdi
9. GOOGOLOLO has a big mouth
10. Russia did condemn it
They were wrong, but not allies
11. A burden to its neighbours
This turkey doesn't realize what its saying but he's coming very close to what the prophet Zechariah says, "And in that day will I make Jerusalem a burdensome stone for all people: all that burden themselves with it shall be cut in pieces, though all the people of the earth be gathered together against it" Zechariah 12:3 And do notice the latter part of this unique prophecy!
Mr Durling ,
12. what a joker :))
turkey and allies in the same sentence??? but must admit he has the gul....:))
les ,
13. Burden? Allies? Haji gul We Know Your Agenda!
You have a GENOCIDE on your southern border!!! Building in Israel is NO concern to turkey, eu, and West!!!! Bibi Is The One Who Should Be Yelling From The Rafters About Allies!!!!!!!!!!!!!! Haji gul You Cut Ties With Israel for a isslimic racist arab Terror group, abu mazen Has Not Held Elections in how long???? Israel Will BUILD, Build and build some more!!!!!!! THE ONLY TRUE DEMOCRACY IN REGION, the world Lamb bastes Israel??????????????? turkey can get STUFFED!!!!!!!!!!!!!!!!!!!!!!
14. Remarkable, isn't it?
Israel warned for months and months that (i) nothing but direct negotiations was acceptable, and that a laundry list of ridiculous preconditions was not acceptable; and (ii) any attempt to circumvent direct negotiations by going to the United Nations to demand a status upgrade would be viewed as a refusal on the part of the ersatz "Palestinians" to negotiate without preconditions, and that the State of Israel would respond accordingly. Doesn't get much more simple or clear than that, does it? So now, Turkey is accusing Israel of attempting to circumvent negotiations by enhancing settlement construction in E-1 -- when Israel has made it abundantly clear that an approach by the ersatz "Palestinians" to the United Nations would mean that negotiations were no longer feasible or possible. Basically, the ersatz "Palestinians" have done what they said they would do, and the State of Israel has done what it said it would do. Chortle -- guess who came out ahead on that one? But it really is remarkable -- the ersatz "Palestinians" do what they said they would do and the international community applauds; Israel does what it said it would do and the international community howls. Can't have it both ways, folks; can't have it both ways.
Sarah B ,
U.S.A. / Israel
15. Stop building in Turkey
It is against peace
St Louis Park MN
16. Turkey
is a huge burden to NATO. at every turn it is looking for a fight with any nation, very eager to shed the blood of NATO soldiers. NATO may have hoped to have influence in the Mid-East through Turkey, instead Turkey is using NATO to bully other nations.
agokoy ,
17. Turkish Bull
Maybe these" turkeys" should think about how they murdured 3 MILLION Armenians and are now trying to destroy the Kurdish people.To all you Turks out there who are condeming Israel- what goes around comes around.
Howard ,
Seattle USA
18. West Bank Settlements
Israel is doing exactly what it should be doing. Obama and Hilary C are not!
Avigdor ,
19. Why E1 building?
Sorry, but I don't understand the reason why Israel's government has decided do build a new settlement in E1 area. Can someone explain such a narrow vision of the political leadership?.Going rosh be rosh and opting for isolation is not a solution, Can't they see the obvious??? Please be wise!
Simone ,
20. Never have agreed with demogogue Erdogan... but this time..
he's actually correct. Netanyahu is a disaster for Israel - and a fine demagogue in his own right.
Rafi ,
21. And the fire in Israel could cook you terks
So watch out . . . you could get burned ! Ha . . . Ha . . . Ha !
Moshe ,
22. #6
The whole world and even the United States are saying the same and refusing Isreal's dangerous plan.
Harold ,
X'mas festival ,
24. What "allies" is he talking about?
If israel is a burden for europe this is their own fault, having taken the wrong decisions. If they woudl ahve forced the Palos instead to come to the table and negotiate and acknowledge Israels rights the issue could have been solved long ago. But Europe prefers to be overtaken by Islamists and listen to their commands, who happily will institute Sharia all over Europe very soon. It's good to be old nowadays!
Mira ,
25. Turkey is a burden to EU!
My friends were flying with Air Turkey from Istanbul to East-Africa. During the flight they followed the map of Middle-East but amazingly on the map they all cities of Israel and Israel itself was removed! This is a crime against humanity! Turkey is a burden to all the world!
Jouko ,
26. Israel becoming a burden to it's allies?
Israel must have some pretty worthless allies.
Noodles ,
Coney Island
27. #6 Harold
When the soon coming Day of Adonai sets in upon the world and you suddenly realize that you have not had your much touted rapture ride out of this world you will be barking up a different tree. I pray you and all those like you who are turning your back on God's Land and God's people will soon open your eyes before it is too late. Try reading the prophets without the distortion of the twisting by the church fathers and you will begin to see.
DavidR ,
28. Correction
My last remarks was intended to be for Harold at #22, not #6.
DavidR ,
29. #22, how is building E1 a "dangerous plan" ?
Building in E1 does not prevent the creation of a PA state, nor does building in North, South, and East Jerusalem. Nor does annexing Gush Etzion, and the Jordan Valley prevent a PA state from coming into existence. The PA is not negotiating in good faith. When Israel signed Oslo, they intended to create a PA state *within* the West Bank similar to Andorra. An independent state occupying all disputed territories was never the goal of Oslo.
Jake ,
30. March Of LOOSER....Turkey??!!
Asher ,
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