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Article Date: 5/1/2008
■ "SiRNAs won the Nobel Prize for medicine — and with good reason."
So says Sam Reich, executive vice president of OPKO Ophthalmics and codeveloper of bevasiranib, OPKO's injectable treatment for wet AMD and currently the only siRNA (small interfering RNA) drug that has reached a pivotal phase 3 trial. Merck is also developing a siRNA drug for the treatment of wet AMD.
Reich agreed to be interviewed by Retinal Physician to discuss the siRNA gene-silencing concept in general and bevasiranib in particular. The siRNA concept has been under fire recently following a much-quoted article in the online edition of the journal Nature in which Jayakrishna Ambati, MD, of the University of Kentucky, contended that these drugs could produce harmful side effects by inhibiting necessary blood vessel growth in healthy areas of the body. He also asserted that siRNAs are generic and do not target specific genes.
An initial University of Kentucky news release stated that the harmful side effects were limited to intravenous administration of a siRNA drug, but in a response to a question from Retinal Physician Dr. Ambati said that even a localized injection of a siRNA into the eye could activate the TLR3 receptor and induce adverse effects.
While Reich made it clear that he did not want to rebut Dr. Ambati on specific issues or contest the reliability of the mouse model that Dr. Ambati used to draw his conclusions, he pointed to 6 years of "validated" data on bevasiranib demonstrating the safety and effectiveness of the drug.
"We have a comprehensive body of data including multiple experiments on mice, rats, rabbits, and monkeys with all demonstrating positive results," said Reich. "We now also have 2 years of data on 200 human patients receiving multiple injections that tell us that bevasiranib is a safe drug that potently silences VEGF via the RNA interference mechanism."
Reich said that bevasiranib had been administered both by intravitreal injection (in humans and animals) and intravenously (in animals) and that neither form of administration had caused harmful side effects.
"We have a tremendous body of evidence that bevasiranib is safe," Reich asserted. "The safety issue is no contest."
On the question of whether bevasiranib actually targets cells rather than triggering a general immune response, Reich said that he is currently preparing a paper on the "ocular bio-distribution of siRNA after ocular injection" that will deal with that issue.
"The drug goes where it needs to go," he said. "We can provide ample evidence that bevasiranib gets to the back of the eye to treat wet AMD. It gets inside cells to silence genes."
Reich appeared to be philosophical in discussing the controversy that has erupted around the siRNA concept.
"Academic models can produce novel findings but to say that they have clinical relevance requires a huge leap of faith," he noted. "The huge preponderance of the hundreds, even thousands of papers on siRNAs at every kind of medical meeting testifies to their potential value. Every pharmaceutical and biotech company that I know of has an interest in siRNAs."
In response to a specific question about the 2-year phase 3 trial for bevasiranib that began last August, Reich said that all the data remain masked but that no significant safety issues had been reported.
■ Researchers from The University of Pennsylvania have used gene therapy to safely restore vision in 3 young adults with a rare form of congenital blindness. Although the patients have not achieved normal eyesight, the preliminary results set the stage for further studies of an innovative treatment for this and possibly other degenerative retinal diseases.
An international team led by The University of Pennsylvania, The Children's Hospital of Philadelphia, the Second University of Naples, and the Telethon Institute of Genetics and Medicine (both in Italy), and several other American institutions reported their findings in an online article in the New England Journal of Medicine.
"This is the first gene therapy trial for a non-lethal pediatric condition," said Albert M. Maguire, MD, associate professor, Department of Ophthalmology, University of Pennsylvania School of Medicine, and a physician at The Children's Hospital of Philadelphia. Dr. Maguire, together with his wife, Jean Bennett, MD, PhD, professor of ophthalmology at Penn and senior investigator at the F.M. Kirby Center for Molecular Ophthalmology at Penn's Scheie Eye Institute, have been researching inherited retinal degenerations such as Leber congenital amaurosis (LCA), for 18 years. LCA usually begins stealing sight in early childhood and causes total blindness during a patient's 20s or 30s. Currently, there is no treatment for LCA.
"Patients' vision improved from detecting hand movements to reading lines on an eye chart," Dr. Maguire said. In 2001, Drs. Bennett and Maguire were part of a team that reported successfully reversing blindness using gene therapy on dogs affected by the same naturally occurring form of congenital blindness.
The scientists used a vector, a genetically engineered adeno-associated virus, to carry a normal version of the gene, called RPE65, that is mutated in one form of LCA. The 3 patients, one 19 years old and 2 age 26, received the gene therapy via a surgical procedure that was performed by Dr. Maguire between October 2007 and January 2008 at The Children's Hospital of Philadelphia, where the gene vector was manufactured at the hospital's Center for Cellular and Molecular Therapeutics (CCMT).
Starting 2 weeks after the injections, all 3 patients reported improved vision in the injected eye. "Standard vision tests showed significantly improved vision in the patients," said Alberto Auricchio, MD, a study leader from the Telethon Institute of Genetics and Medicine and University of Naples Federico II. The researchers also reported that each injected eye became approximately 3 times more sensitive to light, and each was improved compared to the uninjected, previously better functioning eye.
The LCA gene therapy vector showed no signs of causing inflammation in the retina or other toxic side effects. One of the 3 patients had an adverse event, a hole in the retina that did not affect eyesight and may have been surgery-related, rather than related to biological effects of the therapeutic gene or the vector used to carry it.
The patients enrolled in the study to date were identified at the Department of Ophthalmology at the Second University of Naples, an institution with longstanding experience in collecting and studying patients with inherited retinal diseases.
Testing continued over 6 months following the gene therapy vector administration. One patient was better able to navigate an obstacle course compared to before the injection. The patients also had less nystagmus, which is common in LCA. In the patient who experienced better vision even in the uninjected eye, the researchers suggest that the reduced nystagmus benefited both eyes.
"The current clinical trial will continue with more patients and with ongoing follow-up to monitor results," said Dr. Bennett. "We expect improvements to be more pronounced if treatment occurs in childhood, before the disease progresses.
"Much of the funding for degenerative retinal disease research is being provided by wealthy venture capitalist Gordon Gund and the Foundation Fighting Blindness. Gund, who has a rare form of retinitis pigmentosa, is blind.
■ Regeneron Pharmaceuticals Inc. and Bayer HealthCare AG said that VEGF Trap-Eye dosed prn for wet AMD for 20 weeks maintained the visual acuity (VA) gains achieved after an initial 12 weeks of fixed dosing. In addition, 55% of the patients who received the highest dose (2 mg) monthly for the initial 12 weeks did not require any additional injections throughout the entire 20-week prn dosing period.
A full analysis of the 32-week results of a 52-week phase 2 study was recently presented at the 2008 Association for Research in Vision and Ophthalmology (ARVO) meeting.
Study results showed that across all dose groups in the study population, the 6.6 mean letter gain in visual acuity achieved vs baseline at the week 16 evaluation visit, following 12 weeks of fixed dosing, was maintained out to week 32 using a prn dosing schedule. A decrease in retinal thickness was also maintained for all dose groups combined at week 32.
In this double-masked, prospective, randomized, multicenter trial, 157 patients in 5 dose groups were treated with VEGF Trap in 1 eye. Two groups initially received monthly doses of 0.5 or 2 mg of VEGF Trap for 12 weeks and 3 groups received quarterly doses of 0.5, 2, or 4 mg of VEGF Trap (at baseline and week 12). Following the initial 12-week fixed-dose phase of the trial, patients continued to receive therapy at the same dose on a prn dosing schedule based on prespecified criteria.
Patients were monitored for safety, retinal thickness, and visual acuity.
Patients receiving monthly doses of VEGF Trap-Eye, either 0.5 or 2 mg, for 12 weeks followed by prn dosing thereafter achieved mean improvements in VA of 8.0 and 10.1 letters, respectively, and mean decreases in retinal thickness of 141 and 162 μm at week 32, respectively. Dosing prn also maintained the improvements in retinal thickness following a fixed quarterly dosing regimen, but results achieved with the quarterly regimen were generally not as robust as obtained with initial monthly dosing.
VEGF Trap-Eye was generally safe and well tolerated, and there were no drug-related serious adverse events. There was one reported case of culture-negative endophthalmitis/uveitis in the study eye, which was deemed not to be drug-related. The most common adverse events were those typically associated with intravitreal injections.
After the last fixed-dose administration at week 12, patients from all dose groups combined required, on average, only 1 additional injection over the following 20 weeks to maintain the VA gain established during the fixed-dosing period. As noted above, 55% of the patients who received 2 mg monthly for 12 weeks did not require any additional treatment throughout the next 20-week prn dosing period. Moreover, 97% of the patients who received 2 mg monthly for 12 weeks did not require redosing at the week 16 evaluation visit, indicating that an 8-week dosing schedule may be feasible.
"Due to its high affinity for all isoforms of VEGF-A and PlGF, potent mediators of blood vessel overgrowth in wet AMD, as well as its long residence time in the eye, it is anticipated that VEGF Trap-Eye may be able to be dosed at a frequency less than once monthly, especially on a chronic basis, without compromising visual acuity," said primary investigator Quan Dong Nguyen, MD, MSc, assistant professor of ophthalmology, Wilmer Institute, the Johns Hopkins University School of Medicine, Baltimore.
Retinal Physician, Issue: May 2008


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Counterterrorism Calculus in Yemen Shortchanging Political Solutions/
Correction: This post was mistakenly attributed to Issandr El Amrani when first published. It was actually written by Paul Mutter — apologies.
The Washington Post, stating what ought to be obvious about the US "secret war" in Yemen:
In Yemen, U.S. airstrikes breed anger, and sympathy for al-Qaeda
Since January, as many as 21 missile attacks have targeted suspected al-Qaeda operatives in southern Yemen, reflecting a sharp shift in a secret war carried out by the CIA and the Joint Special Operations Command that had focused on Pakistan.
But as in the tribal areas of Pakistan, where U.S. drone strikes have significantly weakened al-Qaeda's capabilities, an unintended consequence of the attacks has been a marked radicalization of the local population.
The evidence of radicalization emerged in more than 20 interviews with tribal leaders, victims' relatives, human rights activists and officials from four provinces in southern Yemen where U.S. strikes have targeted suspected militants. They described a strong shift in sentiment toward militants affiliated with the transnational network's most active wing, al-Qaeda in the Arabian Peninsula, or AQAP.
Presumably, the CIA would disagree that this sort of approach is undermining US counterterrorism efforts - even though it it is said that it deeply disturbs the White House when "errors" like this occur:
On December 17 [2009], the Yemeni government announced that it had conducted a series of strikes against an Al Qaeda training camp in the village of al Majala in Yemen's southern Abyan province, killing a number of Al Qaeda militants. As the story spread across the world, Shaye traveled to al Majala. What he discovered were the remnants of Tomahawk cruise missiles and cluster bombs, neither of which are in the Yemeni military's arsenal. He photographed the missile parts, some of them bearing the label "Made in the USA," and distributed the photos to international media outlets. He revealed that among the victims of the strike were women, children and the elderly. To be exact, fourteen women and twenty-one children were killed. Whether anyone actually active in Al Qaeda was killed remains hotly contested.
Or rather, we believe it deeply disturbs the White House, since as the Daily Kos diarist Jesselyn Radack notes, the White House "can neither confirm nor deny" the air war in Yemen and invokes a black ops non-disclosure rule to keep the books closed.

subset: commoncrawl


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campaign to watch: tripling the impact (today!) for mom and dad.
David wasn't born in September. But after watching the September Campaign trailer and learning more about our mission to bring clean water to every Bayaka in Central African Republic, he knew he had to help somehow.
So instead of giving up his birthday, David is using his parents' birthdays and wedding anniversary, which are all in September. And he's not just asking for donations in John and Connie's honor… today (for John's birthday), he's matching each dollar donated with $2 — a dollar for mom, a dollar for dad!
"I want to get as many strangers involved as possible. I'm hoping people will find this inspiring and tell their friends to give at least something, since I'm tripling each donation. Matching funds in my parents' name… it's one of the coolest gifts I can give to someone else."
– David Roeske
David's parents didn't even know about the campaign until today, which makes the gift extra fun. Happy birthday today to John! And happy fundraising to David… he's asking personally that we put his money where his mouth is (x2)!


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Well video game wise i play a lot and I'm amateur at scoring for games. Mostly I'm in a band witch takes my time plus school but i always play games when i can. You might find me a little dark at times but i can be happy bright and all that but whatever I'm me and that's how its gonna stay.
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|Mural Board -This is were we create our magical murals!
Saturday, January 28, 2012
9 comments:
These guys are my favorite! I love your students' vikings.ReplyDelete
So awesome. I love the color choice for the background. Would have never thought of that color scheme. Good job!ReplyDelete
I have a question for you and any other art teachers out there. Do you teach only elementary? I am in a private school, part time, and instruct students from three years old up to 14 years old. At this point in the year I am feeling frustrated at the lack of time I have to display art work. My schedule is crazy this year and I'm scratching my head wondering why I can't get things done. Any advice? Thanks!Replies
Thanks! I teach elementary and 6th grade. I really try to have kids help do the display when ever possible. After the students prepare the projects for displaying I hang them up after school I guess after 16 years I have finally figured it out! :)Delete
Thank you for your response. I'm guilty of not utilizing my students enough. They are generally eager helpers. I have to remind myself to make a schedule that gives me and the kids some direction as to when to come down to the art room. After all my years you'd think I'd have that down pat. It's an after thought with me too often and a little of me wanting to do it all. Sitting home sick this weekend and trying to figure it all out. It was a rather frustrating week last week. I'll be back in the saddle soon. Thanks again, keep on inspiring us.ReplyDelete
What a great idea! Love those burly vikings!ReplyDelete
What a great project!ReplyDelete
I must try these with my students as our mascots are the Vikings! very cool -thanks.ReplyDelete


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Gli Amici Di Claudio (Friends of Claudio) Photo Gallery / Wallpaper Since inheriting the Cagiva..
2014 Gli Amici Di Claudio On Aug. 17, 2011, the motorcycle industry lost one of..
2013 MV Agusta Brutale 800 & Brutale 675 Comparison Review MV Agusta's resurgence in the..
MV Agusta F3 675 Test Shortly before his untimely passing from cancer in 2011 at..
MV Agusta
Following is a recent interview of Giovanni Castiglioni before his father, Claudio Castiglioni, passed away on Aug. 17 due to an illness.
It's a hot late May Day in Varese Italy, and I'm sitting in Giovanni Castiglioni's office, MV Agusta CEO since the buy back from Harley-Davidson.
Claudio Castiglioni – 11/22/1946-08/17/2011
"Motorcycles make us dream. They have different colors, they have different sounds. They have shapes that sometimes show what inspired their designers. Sometimes these creations are real works of art that turn the designer into an artist." – Claudio Castiglioni
Motorcycle News
The President of MV Agusta Motor S.p.A., Claudio Castiglioni, 64, passed away Wednesday morning in Varese, Italy after a courageous battle against an illness.
Italian Dream Motorcycle
The MV Agusta F4CC is a motorcycle masterpiece from the mind of Claudio Castiglioni, Managing Director of MV Agusta, hence the CC intitals. With only 100 made and just one available in the UK, the MV F4CC is the ultimate hyper-performance superbike, with a top speed of 195mph. Exotic materials, latest technology and stunning Italian styling make it more than just a motorcycle. This extraordinary bike, on sale at £49,999, deserves a place in any dream garage.
MV Agusta today announced that Design Chief Massimo Tamburini will retire from the company, effective Dec. 31, 2008. Tamburini has been with Cagiva since early 1985 and has headed up MV Agusta's engineering and design center, Centro Ricerche Cagiva, in San Marino for over 13 years, where he and the staff designed what are widely regarded as world-class, premium, high-performance sport motorcycles, including the legendary F4.
Mr. Tamburini Speaks…
Claudio Castiglioni's 100
It has been said that 20 percent of all the art ever created is in Italy. The country overflows with legendary beauty. From the spellbinding Sistine Chapel to da Vinci's The Last Supper; from Michelangelo's David to the Leaning Tower of Pisa; Italy stirs the imagination with its timeless creations.


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Habitat Conditions
Channel Alterations
Lower Subbasin
Streams in the southeast portion of this subbasin has been completely channelized and leveed. Aquatic habitat problems include unstable streambed substrates, loss of deep water habitat, and lack of riparian corridor.
In the western and northern portions of the subbasin, no major channelization projects have occurred. Small channelization projects, gravel pushing, and poor gravel removal methods are widespread and relatively common. The detrimental effects of these activities on the stream health are significant, but localized. It is difficult to quantify the cumulative effects on the streams.
Instream gravel mining formed both the Hendrickson and the Keener Springs pools in the Black River (mining has since ceased). The expected bank failures upstream of these pools due to headcuts have not occurred. However, local residents indicate that the Keener Springs pool is rapidly filling in with gravel.
Upper Subbasin
No large channelization projects have occurred. As in the lower subbasin, small channelization projects, gravel pushing, and poor gravel removal methods are relatively common.
Stream Habitat Assessments
The MDC Stream Habitat Assessment Device (SHAD) was used to describe the quality of streambank, corridor, and channel habitat conditions in the basin. SHAD uses objective measurements and subjective ratings to rank particular habitat parameters into categories. Forty-five and 29SHADs were conducted in the lower and upper subbasins, respectively.
Lower Subbasin
Excluding the Lowland ditches, the majority (62-92%) of the riparian corridors surveyed were classified as "good" (Table Hc01). Only 4% of the corridors on the ditches were rated "good".
Excluding the Lowland ditches, the riparian corridor averaged 60 -75 feet. Along the lowland ditches, the riparian corridor averaged only 11 feet.
Streambank erosion is not a major problem in this subbasin. Only 1% of the 8.5 miles of stream surveyed had severe erosion problems (Table Hc02). The streambank erosion problems which were noted, were all associated with missing riparian corridors. Severe bank erosion is not occurring on the lowland ditches because of soil composition and low stream gradients (~1ft/mile). However, instream woody habitat is completely missing from most ditches.
Upper Subbasin
Of the approximately 18 miles of riparian corridors surveyed, 50-100% were classified as "good" (Table Hc01). Only 0-12% of the riparian corridors were classified as "poor. The average riparian corridor range was 58-100 feet (Table Hc01). However, some streams that were not part of the survey, such as the North Fork of Webb Creek, Doe Run Creek, and Dickson Valley Creek have several miles of corridor that are nonexistent or consists of one row of trees.
While few severely eroding streambanks were noted (Table Hc02), many streambanks were classified as "moderately eroding". Many streams, such as the Black River, are experiencing moderate erosion even with an excellent riparian corridor. This erosion can be attributed to the excessive amounts of gravel bedload in the stream channel. Almost all SHAD surveys had comments regarding large amounts of unconsolidated gravel in the stream channel.
Stream Improvement Projects
As in most river basins, there have been a variety of unsuccessful attempts by private landowners to stabilize streambanks. These attempts include channelization, hard points, bank armoring using a variety of materials including rock, gravel, car bodies, and construction debris. MDC personnel have not installed any improvement projects (e.g., cedar tree revetments) in either subbasin.
Unique Habitats
The state's terrestrial natural resources have been classified into six major categories" Forest, Savanna, Prairie, Primary, Wetland, and Cave communities. These communities have been further divided based on characteristic features such as topography, size, distribution, and characteristic plants (Nelson 1987). The Missouri Department of Conservation's Natural Heritage Program (NHP) has identified 64 high-quality communities in the Black River basin (Table Hc03).
Lower Subbasin
Seventeen high-quality natural communities, representing Forest, Savanna, and Wetland categories, have been identified (Table Hc03). In the Forest category, Dry-Mesic Igneous Forest, Wet Bottomland Forest, and Wet-Mesic Bottomland Forest are present. The only high-quality Savanna community identified is a 60-acre igneous savanna. The Wetland category is represented by Deep Muck Fen, Forested Acid Seep, Forested Fen, Oxbows and Sloughs, Pond Shrub Swamp, and Swamp communities.
Upper Subbasin
The NHP has identified 47 high-quality natural communities (Table Hc03). This subbasin contains both upland and bottomland forest. The upland forest habitats include Dry-Mesic Forest, Mesic Limestone/Dolomite Forest, Dry Igneous Forest, Dry Mesic Igneous Forest, and Mesic Igneous Forest. The bottomland forest type is the Dry-Mesic Bottomland Forest. The Primary communities include the Dry Limestone/Dolomite Cliff, Dolomite Glade, and Igneous Glade. Five Wetland community types (Acid Seep, Deep Muck Fen, Prairie Fen, Forested Fen, and Pond Shrub Swamp) are also present. There is only one Cave community type identified, the Effluent Cave.


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12 Strategies for Young couplesThings to Think About
1. Require commodity associated with what the heck is really important that you experienced. How ever spend your time in case you got 6 months to live on? How could you think about an individual relationship in different ways?
2. Recognize bargain and tolerate this prolonged differences. The majority of delighted young couples discover how to reside having major differences regarding capital, in-laws, vacations, family members house work, or anything else. Acknowledging this differences somewhere between the two of you will not should indicate an individual trust these.
3.Identify and individual a person's frustrations. Frustrations arrive via a lot of methods, do the job, children, education or anything else. Frustrations can come on the existing plus the previous. Prevent dropping frustrations on the partner of which fit in the gym.
4. Snatch your lover performing one thing right. Look for partner symptoms which are attractive, and supplement our own partner whenever he / she may these.
5. Surprise your lover having thoughtfulness. Utilize a person's expertise in your lover in order to you should him or her unexpectedly. Permit your lover to find a person's thoughtfulness by the woman's or perhaps himself. Control a person's discouragement if your partner misses a person's energy. Attempt one thing otherwise.
6. Define out and about "couple time" your lover will certainly take pleasure in. Our own chaotic life often fill up having responsibilities. Require period to spend using your partner.
Manage Tense Moments
7. Just before re acting angrily, matter in order to five. The following aged proverb really functions. Converse a person's level, but devoid of the wrath. Each and every appearance associated with negative feelings calls for several expressions associated with confident feelings in order to regain a placement associated with neutral sensation. (For more, click "Emotional Flexibility Techniques®")
8. Make a deal a non-traditional location in order to explore contentious troubles. Going from a typical site associated with justifications in order to yet another place can move a person's disagreements ample to scale back negative emotions and bring in new strategies.
9. Please take a periods. Whenever troubles get excited, politely claim a twenty-minute periods then come back that has a quiet develop plus the intention in order to bargain.
10. After you realize you get a mistake, apologize. Number of us all reside strongly that has a partner without having creating a few mistakes. Disclose a person's failing, express a person's apologies, and investigate strategies to prevent this mistake when you need it.
Listen with Your Heart
11. Supply help, options are usually legitimate. Sensation affixed is really a powerful joining push within a romantic relationship. A lot of companions seek out to relief this frustrations associated with standard of living by sharing these that has a partner. Actually jamming fosters togetherness. The majority of us impatient fans endeavor to reduce accomplishing this by offering options just before our own partner is definitely wanting to listen to these. Tune in initial. In case a resolution takes place to you personally express, "When you might be prepared, pricey, I've a fix dress yourself in be beneficial to you personally. " Whenever your lover is definitely prepared, he / she could be more offered to a person's idea.
12. Seriously tune in to your lover. Upon a worry that may be crucial that you your lover, replicate a person's partner's words to ensure he / she is aware you might be actually jamming. Continue the following way up when your lover is definitely finished, express this some the majority of tough words within a romantic relationship, "Is right now there more? " Proceed jamming till your lover can resolution "No" to this issue. This is tough to try and do but is definitely can proceed further in order to conditioning a person's relationship.


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Can pregnancy cause my anxiety disorder to get worse?
I am 27 weeks pregnant and have suffered from an anxiety disorder for the past 2 years. This past week it seems like my anxiety has gotten worse. Does this have anything to do with being pregnant?
Posted: 12/18/2012 by missmichellebryant
Mom Answers
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It certainly can make it worse! I have panic attack anxiety disorder, and with my first, it seemed to clam me down, now with my second i get worked up much quicker and my anxiety is worse. It has to do with the hormone chages in your body and the mindset you let yourself get into too.posted 12/18/2012 by Aautumn
I UNDERSTAND what you are going through.And it doesn't help to know I my end up w/a c-section being I'm having twins.Im going to talk to my dr about what I can do because it's GETTING WORSE !!good luckposted 12/19/2012 by keisha_and_joe06
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Implantation after miscarriage? Pregnant first month after miscarriage? Help!
I'm looking for someone to help me understand what's going on with me if you've had this experience before or what your thoughts are. I miscarried at 9 weeks pregnant on Dec 22nd. Eleven days later my bleeding subsided and I stopped spotting on Jan 3rd. Ten days later on Jan 13th at night I had major cramps and went to the bathroom and had a little bright red blood just once and than spotted dark brown/red not even a panty liner full and than nothing the next day. (the pain from the cramping was bad to were I took 800mg of Ibuprofin). Now Jan 22nd (almost 10 days after the bright red bleeding) I've had some brown spotting maybe a panty liner full all day today. And mind you for about 5 or 6 days I was feeling very PMSy but today I don't feel PMS anymore and feel pretty "normal" besides my breast have been hurting for almost 2 weeks but I figure that could be because of the miscarriage hormone change. Any thoughts? So far my pregnancy tests show negative.
Posted: 01/22/2013 by dancingjeans
Mom Answers
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1 - 2 of 2 answers
I think you can be pregnant I would go to your doctor (sorry I know this is late ) but I say if you wanted to go ahead it's no different than waiting three or six months it would happen no matter how long you waited, it's mainly to do with dating when you got pregnant, which U/S helps with that, if you are ok emotionally and physically after your miscarriage and your doctor says it's up to you go for it they say it's nothing you did wrong if you have another miscarriage it was fate I am sorry about that and for your loss just hang in there and take care of yourself good luck! and a lot of baby dust to you! <3posted 04/24/2013 by Angels13
I think if you had a miscarriage you should have been giving your body rest for at least a month. You shouldn't be worried about being pregnant when you're child just died, but anyways you grown if you feel you might be pregnant take a test by the beginning of feb.posted 01/24/2013 by a BabyCenter Member
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items tagged with Village of East Davenport
Written By: Jeff Ignatius
Section: News/Features
Category: Local News
2009-05-13 12:00:00
The meeting scheduled for Tuesday, May 12, has been described as the beginning of a master-planning process for Lindsay Park, with the potential impact to spill over into the Village of East Davenport. Darrin Nordahl, of the City of Davenport's Design Center, described the process as "very long and involved" and said he envisioned meetings to the end of the year.
But for many opponents of shifting the use of some park land - largely for parking for Village businesses - the process already appears well underway.
Read More About Park Or Parking?: As The Lindsay Park Planning Process Gets Underway, Battle Lines Are Already Drawn...
Written By: Mike Schulz
Section: Theatre
Category: Feature Stories
2007-12-12 08:28:07
"Everybody's like, 'What happened?'"
That's Chris Jansen, artistic director of New Ground Theatre, recalling a common comment received in the months after June's New Ground production of Living Here at Davenport's Nighswander Theatre.
It turns out that something rather monumental has happened with New Ground, as Jansen and her organization have rented the Village of East Davenport's Turner Hall, and are in the process of having a number of local theatrical groups join them there. But you can certainly understand the concern of Jansen's audiences, as one of New Ground's most recent pieces appeared to be almost frighteningly prophetic.
Read More About Hall Of Fudge: New Ground'S Chris Jansen Plans To Make Turner Hall A Home For Emerging Theatre...
There are 2 items tagged with Village of East Davenport. You can view all our tags in the Tag Cloud


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71 is the number of an apartment where we stay regularly in Whinfell Forest, Cumbria. We like it there.
'We' are Anna French and Dan Hartland. Anna has an MA in Museum and Heritage Studies and a PhD in History, and lectures in early modern history at the University of Liverpool – this may be why she posts here less these days. Dan, meanwhile, is a self-employed writer and musician with a particular specialism in the interweb, science fiction and alt.country.
'The Story and the Truth' is an inadequate catch-all term for what we do here, which is mostly talk about whatever interests and inspires us. That usually includes, for Dan, literature, history, music, film and politics, and for Anna retro and vintage fashion, history, nostalgia, travel, art, cookery, animals and photography.
For more, take a look here.


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|United Kingdom
|Dating Factory


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False Killer Whale's Amazing Echolocation Abilities
In a new experiment, Kina the false killer whale demonstrates her ability to focus her echolocation beam on a target much as humans focus our eyes. Plots of a slowed-down series of clicks allowed researchers to measure the shape of the sound beam.
Credit: Courtesy Laura Kloepper, University of Hawaii


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Kentuckiana Oral & Maxillofacial Surgery Associates Breaks Ground on $4M ASC
The two-story building will feature space for the practice, a new surgery center and a continuing education suite. The six-surgeon practice also operates centers at Jewish Hospital Downtown, on Brownsboro Road and in Mount Washington in Bullitt County.
Related Articles on Transactions & Valuation:
New Jersey's Malo Health and Wellness to Open Four-OR Surgery Center
10 Characteristics That Increase Surgery Center Risk
Wisconsin's Waukesha Memorial Hospital to Build Edwin A. Gallun Jr. Family Surgical Center
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Frink,N.T., Pirzadeh, S.Z, Parikh, P.C., Pandya, M.J., and Bhat, M.K., "The NASA Tetrahedral Unstructured Software System" , The Aeronautical Journal, Vol. 104, No. 1040, October 2000, pp. 491-499. (Download Conference Paper)
VGRID Tetrahedral Grid Generator
Kania, L. and Pirzadeh, S. Z., "A Geometrically-Derived Background Function for Automated Unstructured Mesh Generation", AIAA 2005-5240, June 2005.
Parikh, P., Pirzadeh, S., and Lohner, R., "A Package for 3-D Unstructured Grid Generation, Finite-Element Flow Solutions, and Flow-Field Visualization", NASA CR-182090, September 1990.
Pirzadeh, S., "Recent Progress in Unstructured Grid Generation ", AIAA 92-0445, January 1992.
Pirzadeh, S., "Structured Background Grids for Generation of Unstructured Grids by Advancing Front Method", AIAA Journal, Vol. 31, No. 2, February 1993, pp. 257-265.
Pirzadeh, S.: "Viscous Unstructured Three-Dimensional Grids by the Advancing-Layers Method", AIAA 94-0417, January 1994.
Pirzadeh, S.: "Unstructured Viscous Grid Generation by Advancing-Layers Method", AIAA 93-3453, August, 1993. Also, AIAA Journal, Vol. 32, No. 8, August 1994, pp. 1735-1737.
Pirzadeh, S., "Three-Dimensional Unstructured Viscous Grids by the Advancing Front Method", AIAA Journal, Vol. 34, No. 1, January 1996, pp. 43-49.
Pirzadeh, S.: "Progress Toward A User-Oriented Unstructured Viscous Grid Generator", AIAA 96-0031, January 1996.
Pirzadeh, S. Z.: "An Adaptive Unstructured Grid Method by Grid Subdivision, Local Remeshing, and Grid Movement", AIAA 99-3255, June, 1999.
GridTool Graphic User Interface
Samareh-Abolhassani, Jamshid, "Unstructured Grid on NURBS Surfaces", AIAA-Paper 93-3454.
Samareh-Abolhassani, Jamshid, "Unstructured Surface Grid Generation", NASA CP-10119, pp. 223-251, September 1993.
Samareh-Abolhassani, Jamshid, "Triangulation of NURBS Surfaces", in Numerical Grid Generation in Computational Fluid Dynamics and Related Fields, ed. Weatherill, N. P., et. al., Pineridge Press, pp. 377-388, 1994.
Samareh, J. A.: "GridTool: A Surface Modeling and Grid Generation Tool", Proceedings of the Workshop on Surface Modeling, Grid Generation, and Related Issues in CFD Solutions, NASA Lewis Research Center, Cleveland, OH, NASA CP-3291, 1995, May 9-11, 1995,
USM3D Flow Solver
Abdol-Hamid, K. S., Frink, N. T., Deere, K. A., and Pandya, M. J.: "Propulsion Simulations Using Advanced Turbulence Models with the Unstructured-Grid CFD Tool, TetrUSS", AIAA 2004-0714, January 2004.
Bhat, M.K.: "Parallel Implementation of an Unstructured Grid-Based Navier-Stokes Solver", AIAA 99-0663, January 1999.
Frink, N. T., Parikh, P., and Pirzadeh, S., "A Fast Upwind Solver for the Euler Equations on Three-Dimensional Unstructured Meshes", AIAA 91-0102, Jan. 1991.
Frink, N. T., "Three-Dimensional Upwind Scheme for Solving the Euler Equations on Unstructured Tetrahedral Grids", Ph. D. Dissertation, Virginia Polytechnic Institute and State University, September 1991.
Frink, N. T.: "Upwind Scheme for Solving the Euler Equations on Unstructured Tetrahedral Meshes." AIAA Journal, Vol., No. 1, January, 1992, pp. 70-77.
Frink, N. T., "Recent Progress Toward a Three-Dimensional Unstructured Navier-Stokes Flow Solver", AIAA 94-0061, January 1994.
Frink, N. T., "Assessment of an Unstructured-Grid Method for Predicting 3-D Turbulent Viscous Flows", AIAA 96-0292, January 1996.
Frink, N. T., "Tetrahedral Unstructured Navier-Stokes Method for Turbulent Flows", AIAA Journal, Vol. 36, No. 11, November 1998, pp. 1975-1982.
Frink, N.T., Bonhaus, D.L., Vatsa, V.N., Bauer, S.X.S, Tinetti, A.F., "A Boundary Condition for Simulation of Flow Over Porous Surfaces", Journal of Aircraft, Vol. 40, No. 4, July-August 2003, pp. 692-698. (Download Conference Paper)
Pandya, M. J.: "Low-Speed Preconditioning for an Unstructured Grid Navier-Stokes Solver", AIAA 99-3134, June 1999.
Pandya, M. J. and Frink, N. T.: "Agglomeration Multigrid for an Unstructured-Grid Flow Solver", AIAA 2004-0759, January 2004.
Pandya, M. J. Frink, N.T., Abdol-Hamid, K.S., and ĺĘChung, J.J.: "Recent Enhancements to USM3D Unstructured Flow Solver for Unsteady Flows", AIAA 2004-5201, August, 2004.
Pandya, M.J., Frink, N.T., and Noack, R.W.: "Progress Toward Overset-Grid Moving Body Capability for USM3D Unstructured Flow Solver", AIAA 2005-5118, June 2005.
Pandya, M.J., Abdol-Hamid, K.S., Campbell, R.L., and Frink, N.T., "Implementation of Flow Tripping Capabiliity in the USM3D Unstructured Flow Solver", AIAA 2006-0919.
Parikh, P.C., "Application of a Scalable, Parallel, Unstructured-Grid-Based Navier-Stokes Solver", AIAA 2001-2584, June 2001.
Wang, Q., Massey, S. J., Abdol-Hamid, K. S., and Frink, N. T., "Solving Navier-Stokes Equations with Advanced Turbulence Models on Three-Dimensional Unstructured Grids" , AIAA 99-1056, January 1999.
Wang, Q., Massey, S. J., and Abdol-Hamid, K. S., "Implementation of Advanced Two Equation Turbulence Models in the USM3D Unstructured Flow Solver", NASA/CR-2000-210102, April 2000, pp. 36, (3.9MB)
Applications of TetrUSS
Bobskill, G. J., Parikh, P. C., Prabhu, R. K., and Tyler, E. D.: " Aerodynamic Database Development of Mars Smart Lander Vehicle Configurations", AIAA 2002-4411, August 2002.
Bonhaus, D. L. and Maddalon, D. V.: "Assessment of an Euler-Interacting Boundary Layer Method Using High Reynolds Number Transonic Transport Flight Data" , NASA/TP-1998-208461, August 1998
Campbell, R., Carter, M., Pendergraft, O., Friedman, D., and L. Serrano, L., "Design and Testing of a Blended Wing Body with Boundary Layer Ingestion Nacelles at High Reynolds Numbers (Invited)", AIAA-2005-0459, January 2005.
Campbell, R. L.: "Efficient Viscous Design of Realistic Aircraft Configurations", AIAA 98-2539, June 1998.
Carlsen, W.D., "Development of Transonic Area-Rule Methodology", Journal of Aircraft, Vol. 32, No. 5, pp. 692-698.
Chaffin, M.S. and Pirzadeh, S.Z., "Unstructured Navier-Stokes High-Lift Computations on a Trapezoidal Wing", AIAA 2005-5084, June 2005.
Deere, K.A. and Pandya, M.J.: "Propulsion Simulations with the Unstructured-Grid CFD Tool TetrUSS", AIAA 2002-2980, June 2002.
Dodbele, S. S.: "Three Dimensional Aerodynamic Analysis of a High-Lift Transport Configuration" , AIAA 93-3536, August, 1993.
Fouladi, K.: "Unstructured Grids for Sonic-Boom Analysis", AIAA 93-2929, July, 1993.
Frink, N. T., Parikh, P., and Pirzadeh, S., "Aerodynamic Analysis of Complex Configurations using Unstructured Grids", AIAA 91-3292, September 1991.
Frink, N. T., Pirzadeh, S., and Parikh, P., "An Unstructured-Grid Software System for Solving Complex Aerodynamic Problems" , NASA CP-3291, pp. 289-308, May 9-11, 1995.
Frink, N.T. and Pirzadeh, S.Z.: "Tetrahedral Finite-Volume Solutions to the Navier-Stokes Equations on Complex Configurations" Int. J. Numer. Meth. Fluids 31 pp. 175-187 (1999). Also as NASA/TM-1998-208961, , December 1998, (HTML Summary)
Frink, N. T. and Pirzadeh, S.: "Unstructured Navier-Stokes Analysis of Full TCA Configuration", NASA CP-1999-209692, Vol. 1, Part 1, December 1999, pp. 309-327.
Frink, N. T., Allison, D. O., and Parikh, P. C.: "Unstructured Navier-Stokes Analysis of Wind-Tunnel Aeroelastic Effects on TCA Model 2", NASA/CP-1999-209704/VOL1/PT1, December 1999, pp. 621-640
Ghaffari, F.: "On The Vortical-Flow Prediction Capability Of An Unstructured Grid Euler Solver", AIAA 94-0163, January, 1994.
Ghaffari, F.,"Unstructured Grid Euler Method Assessment for Longitudinal and Lateral/Directional Stability Analysis of the HSR Reference H Configuration at Transonic Speeds", NASA/TM-1999-209526, December 1999.
Ghaffari, F.: "Unstructured Grid Viscous Flow Simulation Over High-Speed Research Technology Concept Airplane at High-Lift Conditions", NASA TP 1999-209718, November 1999. (2.4Mb)
Ghaffari, F., "Unstructured Grid Euler Method Assessment for Aerodynamic Performance Prediction of the Complete TCA Configuration at Supersonic Cruise Speed", NASA/CP-1999-209692, Vol. 1, Part 1, December 1999, pp. 287-307.
Ghaffari, F., "Unstructured Grid Euler Method Assessment for Longitudinal and Lateral/Directional Aerodynamic Performance Analysis of the HSR Technology Concept Airplane at Supersonic Cruise Speed", NASA/TP-1999-209543, December 1999.
Goble, B.D. and Hooker, J.R.: "Validation of an Unstructured Grid Euler/Navier-Stokes Code on a Full Aircraft with Propellers", AIAA 2001-1003, January, 2001.
Green, B. and Chung, J., "CFD Predictions of the Stability and Control Characteristics of the Pre-Production F/A-18E", AIAA 2005-6122, Aug. 2005.
Hooker, J., "Aerodynamic Development of a Refueling Pod for Tanker Aircraft", AIAA 2002-2805, June 2005.
Hooker, J., Hoyle, D., and Bevis, D., "The Application of CFD for the Aerodynamic Developement of the C-5M Galaxy", AIAA 2006-0856, Jan. 2006.
Hunter, C.A., Viken, S.A., Wood, R.M., and Bauer, S.X.S: "Advanced Aerodynamic Design of Passive Porosity Control Effectores", AIAA 2001-0249, January 2001.
Kern, S. and Bruner, C.: "External Carriage Analysis of a Generic Finned-Store on the F-16 Using USM3D", AIAA Paper No. 96-2456, June 18-20, 1996.
Kinard, T. A., and Harris, B. W.: "Evaluation of Two Unstructured CFD Methods", AIAA 94-1877, June 1994.
Kinard, T.A. and Raj, P.: "Euler Technology Assessment for Preliminary Aircraft Design - compressibility Predictions by Employing the Unstructured Grid USM3D Code", NASA CR-4711, March 1996.
Kinard, T.A., Finley, D.B., and Karman, S.L., Jr.: "Prediction of Compressibility Effects Using Unstructured Euler Analysis on Vortex Dominated Flow Fields", AIAA 96-2499, June 1996.
Kwon, O. J., and Hah, C.: "Three-Dimensional Unstructured Grid Euler Method Applied to Turbine Blades", AIAA 93-0196, January, 1993.
Kwon, O.J., and Hah, C.: "Solution of the 3-D Navier-Stokes Equations with a Two-Equation Turbulence Model on Unstructured Meshes Applied to Turbomachinery", AIAA 94-1833, June 1994.
Lessard, W. B.: "Subsonic Analysis of 0.04-Scale F-16XL Models Using an Unstructured Euler Code", NASA TP 3597, 1996.
Londenberg, W.K.: "Computational Assessment of Aft-Body Closure for the HSR Reference H Configuration", NASA/CR-1999-209521, December 1999.
Michal, T.R.: "Unstructured Grid Assessment for Viscous Flow Simulations", Wright Laboratory Report WL-TR-97-3079, July 1997.
Mineck, R.E.: "Application of an Unstructured Grid Navier-Stokes Solver to a Generic Helicopter Body - Comparison of Unstructured Grid Results with Structured Grid Results and Experimental Results" , NASA/TM-1999-209510, August 1999, pp. 52, (3MB)
Niewoehner, R.J. and Filbey, J., "Computational Study of F/A-18 E/F Abrupt Wing Stall in the Approach Configuration", Journal of Aircraft, Vol. 42, No. 6, Nov-Dec 2005, pp. 1516-1522..
Pandya, M. J., Bhat, M., and Parikh, P.: "Application of Unstructured Grid Methodology to Rotorcraft Flows", AHS-97, Presented at the American Helicoptor Society Rotorcraft Acoustics and Aerodynamics Specialists Meeting, Williamsburg, Virginia, October 28-30, 1997.
Parikh, P., Pirzadeh, S., and Frink, N. T.: "Unstructured Grid Solutions to a Wing/Pylon/Store Configuration", Journal of Aircraft, Vol. 31, No. 6, November-December, 1994, pp. 1291-1296.
Parikh, P. : "Development of a Modular Aerodynamic Design System Based On Unstructured Grids", AIAA 97-0172, January 1997.
Parikh, P., Engelund,W., Armand, S., and Bittner, R., "Evaluation of a CFD Method for Aerodynamic Database Development Using the Hyper-X Stack Configuration", AIAA 2004-5385, August 2004.
Paresh C. Parikh and James Chung, "A Computational Study of the Abrupt Wing Stall (AWS) Characteristics for Various Fighter Jets, Part I, F/A-18E and F-16C",ĺĘ AIAA 2003-0746, January 6-9, 2003
Parikh, P. and Chung, J., "Computational Study of the Abrupt-Wing-Stall Characteritics of F/A-18E and F-16C", Journal of Aircraft, Vol. 42, May-June 2005, pp. 600-605.
Pirzadeh, S.Z.: "An Adaptive Unstructured Grid Method by Grid Subdivision, Local Remeshing, and Grid Movement", AIAA 99-3255, June 1999.
Pirzadeh, S. Z. and Frink, N. T.: " Assessment of the Unstructured-Grid Software TetrUSS for Drag Prediction on the DLR-F4 Configuration", AIAA 2002-0839, January 14-17, 2002.
Potsdam, M. A., Intemann, G. A., Frink, N. T., Campbell, R. L., Smith, L. A.,and Pirzadeh, S.: "Wing/Pylon Fillet Design Using Unstructured Mesh Euler Solvers", AIAA 93-3500, August, 1993.
Raj, P., Kinard, T.A., and S.A. Vermeersch: "Vortical Flow Simulation Using An Unstructured-Grid Euler Method", ICAS-96-1.4.5, Sorrento, Italy, September 8-13,1996.
Raj, P.: "An Assessment of Unstructured-Grid CFD Methods: COBALT, SPLITFLOW, and USM3D, A Lockheed Martin/Wright Laboratory Cooperative Study", Lockheed Report LG96ER0031, December 1996.
Singh, K.P., Newman, J.C., III, and Baysal, O.: "Dynamic Unstructured Method for Flows Past Multiple Objects in Relative Motion", AIAA 94-0058, January 1994.
Singh, K.P., and Baysal, O.: "3-D Unstructured Method for Flows Past Bodies in 6-DOF Relative Motion", 6th International Symposium of Comp. Flu. Dyn., Sept. 4-8, 1995
Tsung, F._L., Loellbach, J., and Hah, C.: "Developement of an Unsteady Unstructured Navier-Stokes Solver for Stator-Rotor Interaction", AIAA 96-2668, July 1996.
Wai, J., Herling, W. W., and Muilenburg, D. A., "Analysis of a Joined-Wing Configuration", AIAA 94-0657, January 1994.
Walsh, J. and Cenko, A.,"USM3D Predictions of NMK-83 Trajectories from the CF-18 Aircraft", AIAA 2001-2431, June 2001.
Woodson, S.H., Green, B.E., Chung, J.J., Grove, D.V., Parikh, P.C., and Forsythe, J.R., "Understanding Abrupt Wing Stall with Computational Fluid Dynamics", Journal of Aircraft, Vol. 42, No. 3, May-June 2005, pp. 578-585.
Woodson, S. H. and Bruner, C. W. S. Bruner: "Analysis of Unstructured CFD Codes for the Accurate Prediction of Aircraft Store Trajectories", AIAA 99-0123, January 1999.
Masters Thesis Based On USM3D
Carlsen, W.D.: "Development of Transonic Area-Rule Methodology", Master's Thesis for The George Washington University, June 1994.
Cavallo, P.A.: "Coupling Static Aeroelastic Predictions with an Unstructured- Grid Euler/Interacting Boundary Layer Method", Master's Thesis for The George Washington University, July 1995.
Newman, J.C., III: "Flow Simulations About Steady-Complex and Unsteady Moving Configurations Using Structured-Overlapped and Unstructured Grids", Master's Thesis for Old Dominion University, May 1994.
Smith, W.D.: "Improved Pressure and Lift Predictions in Transonic Flow Using an Unstructured Mesh Euler Method with an Interacting Boundary Layer", Master's Thesis for The George Washington University, July 1994.
Ph.D. Dissertations Based On USM3D
Frink, N. T.: "Three-Dimensional Upwind Scheme for Solving the Euler Equations on Unstructured Tetrahedral Grids." Ph.D. dissertation, Virginia Polytechnic and State University, to be defended September 1991.
Singh, K.P.: "Dynamic Unstructured Method for Prescribed and Aerodynamically Determined Relative Moving Boundary Problems", Ph.D. Dissertation for Old Dominion University, August 1995.
Parikh, P., Pirzadeh, S., and Frink, N. T.: "Unstructured Grid Solutions to a Wing/Pylon/Store Configuration Using VGRID3D/USM3D", AIAA 92-4572, August, 1992


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I am 36 weeks and I've been having severe gas and constipation pains since my 2nd trimester
The pains started in sep after a road trip from texas to california, and I would have the pain ever other week after that, I thought it was just the stretching, but I discovered it was severe gas and constipation. The worst pain I have ever felt in my life. My dr gave me kristaolse, I take gas x. I drink mint tea, senna tea (as needed) , changed my diet, tried lemons, milk of magnesium. even 7up. I have learned how to release the gas , but nothing, I mean nothing takes away the pain, not tylenol or vicadon. Has anyone experinced this terrible pain. It has kept me in the bed for 2 months, I been back and forth to the hospital, and nothing is wrong with me or baby thank god, and have talk to my dr about every other week. So at this point, I just have to live with this pain until my baby is born.
Posted: 01/18/2011 by lninas2003
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i am 36 week of pregnancy and have constipationposted 08/05/2012 by a BabyCenter Member
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CHARGERS: Jackson could be on the move
WR would be eligible sooner if he's traded away
SAN DIEGO -- A settlement between the NFL and the NFL Players Association on Thursday would allow Chargers receiver Vincent Jackson to play in the fifth game of the season should he be traded to another team by Wednesday.
Jackson would serve a three-game suspension for violating the league's personal-conduct policy and a one-game suspension for being on the roster exempt list as opposed to the standard three.
The compromise was reached before an arbitration hearing in New York City to determine Jackson's roster-exempt status should he be traded.
"We got two-thirds of what we wanted and Vincent is very happy with that," NFLPA attorney Richard Berthelsen told Yahoo! Sports after he and league attorneys worked out a settlement.
That could help facilitate a trade between the disgruntled receiver and the Chargers, who retain the restricted free agent's rights.
As part of the settlement, a trade moratorium has been placed on trade activity until today at 1 p.m. The Chargers must grant permission for Jackson's agents to speak with other teams about a new contract that would be the first step toward a trade.
After that, all parties have until 1 p.m. Wednesday to complete a deal. If a deal is not reached, Jackson's original six-game suspension will stand.
Jackson was close to being dealt in early September to an unidentified team. A source said then that the team was a contender in the NFC, and reports since have identified that team as the Minnesota Vikings. The sides could not agree on compensation, especially with Jackson scheduled to miss six games.
The Seattle Seahawks and the St. Louis Rams were given permission by the Chargers to talk contract with the Jackson camp. Also, the Washington Redskins have showed interest in Jackson, and Washington coach Mike Shanahan wouldn't rule out the prospect of going after Jackson when the topic was broached by local reporters on Thursday.
The Chargers are not willing to give Jackson away. Acquiring Jackson wasn't cheap when teams tried to acquire him before the regular season began, and a shortened suspension should serve to increase the receiver's trade value. It does not mean a trade is forthcoming.
There's no reason the Chargers would take anything less than a second-round pick for Jackson, especially considering they would likely get a third rounder in 2012 as a compensatory pick should he walk next offseason as a free agent.
While Chargers general manager A. J. Smith has not commented on Jackson since the start of training camp, it's been reported that the Chargers are looking for a second-round pick and a future selection to deal Jackson.
If their terms are not met, a team source said that the Chargers have no problem retaining Jackson's rights all season without the use of his services.
Jackson said he was prepared to sit out the season in protest of his contract status. He refused to sign a $3.268 million contract tender this offseason and didn't sign a tender decrease by roughly $2.5 million on June 15.
Jackson hasn't played or practiced since January. Should he be traded, he would be able to practice with his new team after his personal-conduct suspension concludes following Week 3.
The Chargers are the variable in making a trade happen. Jackson's contract demands were an impediment, but he's backed off demands for a long-term deal in excess of the four-year, $46.5 million deal given to Brandon Marshall.
Jackson is amicable to a one-year deal. He came to terms with the team believed to be the Vikings on a one-year deal worth roughly $7 million in early September, according to an unidentified source.


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Credit: © Jeffrey Mayer/WireImage
Amanda Seyfried (Mar 21st, 2009)
To balance her long hairstyle, Amanda Seyfried neatly clips back the top of her tousled waves.
Styling Tip
Step 1: Mist damp hair with texturizing spray and then blow dry haphazardly while shaking out your hair with your fingers.
Step 2: Avoiding the top six inches, twist a random one-inch section and wrap it around a large curling iron. Hold for a few seconds to set the curl, release and repeat all over. Run fingers through hair to break up sections.
Step 3: Take a large halo section of hair from on top of your head and clip it together in back. Spritz with finishing spray to lock in your style.


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Abishua is sweet and caring. Usually a ladies man. While he may be shy at first he turns out to be a loud person who has many friends and he is joker
He is so Abishua
af udontknowmyname25 19. oktober 2013
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Rationalizing the veil
French President Nicolas Sarkozy opened up a can of feisty worms when he said the burqa is "a sign of subservience." Arab News asks scholars what they think the burqa signifies.
July 12, 2009 1:07 by Dana El Baltaji
French President Nicolas Sarkozy's recent call for a parliamentary commission to look into whether the burqa should be banned in public has once again raised a contentious issue.
Calling the burqa worn by some Muslim women "a sign of subservience", the French leader dismissed the idea that he was attacking Islam.
"We cannot accept to have in our country women who are prisoners behind netting, cut off from all social life, deprived of identity," Sarkozy told the Parliament in a major policy speech that touched on myriad issues. "That is not the idea that the French republic has of women's dignity."
Back in Saudi Arabia, French Ambassador to Saudi Arabia Bertrand Besancenot recently issued written statements to Arab News commenting on what Sarkozy said.
He said the parliamentary commission, which began hearings on Wednesday, consists of MPs from different political parties that are looking into whether the face veil (niqab) is socially acceptable.
Besancenot said the niqab was a "marginal" phenomenon in France, but that its use was increasing and disrupting the traditional social and cultural values of France.
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4 Comments
If France thinks that burqa reflects womens in prison and they don't want these culture then what french people are doing in Arab world and all Arab world / muslim countires should shut-off french embassies and get rid of such people for once and all……………
Will the French ask nuns to shun their headdress too? Well there is a huge difference in identity when a lady's hair is covered and uncovered … even men in uniform and casual dresses has a totally different look! Does Sarkozy have the guts to tell the nuns to get rid of their headdress? Or he is scared to face the wrath?
The first amendment rule of any secular or democratic country is "freedom of expression". I think in this whole argument between France and Islam, the voice of the woman who choose to wear Islamic veils is being ignored.
Anyone who 'chooses' to wear her veils. should be allowed to do so on the very bases of – ITS HER CHOICE. Then who is Sarkozy or a sheikh to comment. The fact that wearing of the burqa is on the rise, the President of France may run an opinion ballot to check the feature he is pegging his argument – ARE WOMAN WEARING THEIR VEILS OUT OF CHOICE OR COMPULSION.
More and more woman across the world are adopting veils. Veils have been a part of the ME even before Islam. It was adopted by the beautiful religion of Islam, which recommends modesty as its core reason behind veiling.
Veils are also worn by orthodox Christians Hindus, Sikh and several other cultures, who is Sarkozy to decide what's social culturally acceptable to a woman of another faith. If France lays claim to Equality then its not up to Sarkozy to 'eliminate' the veil like a dictator. Its got to be a more democratic process – and its got to be the voice of woman who wear veils that should be the deciding factor.
Lutfullah, it's about respecting local norms and values where the person lives, we're not all the same. French (and most Europeans) mostly don't agree with a person being coerced into losing individual freedoms and see this whole subject as being an example of this. When it happens in their country they have the right to question and debate whether they want to trun a blind eye. When they live in other countries they have to respect the country's traditions or choose not to live there. It can be argued that French Muslims have the same choice, live there and respect and abide by the local norms and values or move to a country that upholds the wearing of the niqab. I also think you'll find that it is only the face covering that they are concerned about as this is a sign of subservience that decades of European womens rights movement have been fighting against.
Sameer, it's the question of the possibility of forced subservience that the French and Europeans have a problem with and want to debate. Nuns choose to wear their religious clothes and they don't lose personal fredom because of it, the same for all the other examples you give.


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Collective Soul -- Naperville, IL -- September 1st, 2013
This was a show called the Naperville Last Fling, which was sort of an end-to-the-summer festival. [B]Collective Soul[/B] headlined. A few songs into their set they said they were gonna play all those songs we've heard way too much over the last 19 years, but we were gonna enjoy every minute of it. They were right. The setlist was pretty much what I expected (their hits), but they did throw in a few songs that they don't ALWAYS play, like, "Tremble For My Beloved," "She Said," "Needs," "Better Now," and the big surprise "Sister Don't Cry." In the middle of "Hollywood" they covered a snippet of Pete Townsend's "Let My Love Open The Door." Unfortunately since a big thunder storm was coming in they had to cut their set short. That was understandable, though, because by the time we got to our car 5 minutes after they finished it was absolutely pouring like crazy. I'm assuming the songs that got cut at the end were "Shine," "Run," and possibility 1 or 2 more. Like I always say about about Collective Soul, their setlists are pretty predictable, but I still go see them every chance I get. They are a fantastic live band, and they write great songs. Setlist:
Tremble For My Beloved
She Said
Why Pt. 2
Where The River Flows
Sister Don't Cry
Hollywood / Let My Love Open The Door
Better Now
The World I Know
[QUOTE=kevindeets;539899]and the big surprise "Sister Don't Cry." [/QUOTE]
Awesome. Wish I could've seen that. Or any song from Hints. Run is a great track but I was disappointed by the way they played Shine when I saw them do it. They played it much faster than it should be and you could tell they were just doing it because they had to, like it was a chore. I don't like when bands clearly just want to get it over with. (Uriah Heep did the same thing with The Wizard - super fast, no enthusiasm.)
I'm really only familiar with their first two albums, but I absolutely love those albums and would have loved to seen them just to see the songs I know. Are their other albums worth checking out?
|All times are GMT -8. The time now is 02:42 PM.
Blah Blah Blah Copyright WWW.METALSETLISTS.COM 2008


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SF's Dolby Laboratories in Potrero Hill hosts tonights screening of the Oscar-nominated shorts for SF's ASIFA chapter. As if I'd had any doubts that I was among serious animation fans, chapter president Karl Cohen's next announcement, that the Balboa Theater will be screening some Gumby shorts in honor of the recently-deceased Art Clokey earns an audible gasp from the audience. This group loves animation, and lives animation.
By Andrew Farago
Later Thursday evening, we reconvened at San Francisco's Dolby Laboratories in Potrero Hill for a special screening of the Oscar-nominated shorts for SF's ASIFA chapter. I arrived 45 minutes before the screening for an opportunity to talk shop with Javier, and was not at all surprised to find out that almost a dozen ASIFA members had arrived before me, hoping to stake out good seats in Dolby's theater.
Within five minutes of my arrival, there were another dozen ASIFA members, and by the time Ron, Javier and company arrived, there were probably 40 people—all of whom were at least 30 minutes early for the screening. Being new to the industry, Javier actually went unnoticed as he walked around the room, so I caught up with him pretty quickly and asked him about his time in the U.S. so far.
His biggest regret has been that he hasn't had any time to draw in his sketchbook while he's been on the road, since it's been one cool venue after another since his arrival. Javier's a very humble, very self-effacing guy, and he doesn't think of himself as a great artist, but he's "good enough to pay the bills" with his comic book work. His sketchbook was packed away in the car, unfortunately, so I didn't manage to get a look, but I'll make sure to bug him about it if I ever make it to Granada.
His comics, for the most part, are done for the French and Flemish markets, as their thriving comic book industries are able to pay much better and offer significantly higher exposure than their Spanish counterparts. The Spanish comics industry is very limited, and relies heavily on reprints of American comics, so there's little opportunity for someone to produce work that will find a welcome audience back home.
As a result of his comics training, he fell into animation almost by accident. "You know how to make comics, right? That's pretty close to storyboards. You should work for us." And the rest is animation history. His family had strong doubts about his career choice, but winning the Goya—the Spanish equivalent of an Oscar—and netting an Academy Award nomination have managed to convince them that he's got a future in this business. (I've heard variations on this story from at least a dozen other animators. Oscars carry a lot of weight with moms.)
As much as he enjoyed his other visits, Javier was really excited about his impending trip to Pixar, and was hoping to cross paths with Brad Bird or Bill Presing. "What I really like about Pixar," he said,"is that you can see one of their movies, and you know right away who directed it. With other studios, it's just a product. But with Pixar, it's art."
And if anyone at Pixar wants to hire him, dirt cheap, he said that he'd be happy just to have a small drawing table out in the hallway, with a stack of paper and some pencils. I'm sure it would violate any number of labor laws if John Lasseter scooped up all of the best talents from Europe and locked them away in Pixar's sub-basement, but I'm sure that other studios have done worse.
Javier ran down the list of sites he'd seen in San Francisco, including the Golden Gate Bridge, Haight-Ashbury, the cable cars…and had seen so much that he couldn't remember it all, so I'm hoping that his group managed to take lots of photos while they were tooling around the city.
It's not Javier's first trip to the United States, as he spent an extended period in Rochester, New York studying English as a teenager, but it's his first visit to the west coast, and it would be hard to make a better first impression than a whirlwind tour of Dreamworks, Skywalker Ranch, ILM and Pixar.
All the same, he's looking forward to a brief period of downtime between the Pixar trip and the Oscars, maybe hitting the beach, getting in a little bit of drawing, and spending some time with his mother and her boyfriend, who've also traveled to California. And if he happens to score some time with Scarlett Johansson while he's in Los Angeles, he's certainly not going to complain.
Javier's trying not to get his hopes too high as far as winning the Oscar on March 7, since he's aware that he's up against some stiff competition. Nick Park has won four Oscars from five nominations, and that one loss came in a year when he happened to have two films up against each other, so it would be hard to bet against Aardman. "There's a lot of buzz about Logorama, though," mentions Javier, "and that might win if the judges say, 'Nick Park already has enough Oscars.'" Win or lose, though, he's thrilled to be along for the ride.
As 7:30 approaches, we're told that it's time to go upstairs for the screening. I've only seen the Wallace and Gromit short at this point, and am looking forward to watching the rest, especially The Lady and the Reaper and Logorama, which I've only heard described as "something no distributor will touch in a million years," and I'm curious to find out just what that means.
Clusters of 10-15 people at a time crowd into Dolby's elevators, and the Spanish contingent and I catch one of the last cars to the third-floor theater. One passenger, unaware that she's riding along with some Oscar nominees, asks "What night are the Oscars this year?", and three Spaniards chime in "March seventh" almost before she's finished asking the question.
We take our seats, and ASIFA-SF President Karl Cohen approaches the podium to welcome everyone and run down a list of other upcoming ASIFA events. The always popular "Careers in Animation" seminar has an impressive list of professional animators already on board for portfolio reviews and networking opportunities. Karl promotes an upcoming screening of Waking Sleeping Beauty, a documentary about Disney's "lean years" in the 1970s and 1980s prior to the release of Little Mermaid, and he warns that "some fans online really love it, and some critics really hate it. I haven't seen it yet, so I can't tell you which group is right."
As if I'd had any doubts that I was sitting among some serious animation fans, Karl's next announcement, that the Balboa Theater will be screening some Gumby shorts on April 1 in honor of the recently-deceased Art Clokey earns an audible gasp from the audience. This group loves animation, and lives animation.
Karl surrenders the podium to Ron Diamond, who thanks everyone (probably 100-plus, which is great for a weeknight during a week of really unpredictable, often-rainy weather) for attending. He talks about the origins of the tour, and the underappreciated art of the animated short—which is almost always on the chopping block when the Oscar committee determines which awards to hand out on television and which ones are only worthy of the pre-recorded, not-to-be-aired ceremony. John Lasseter, thankfully, uses his influence every year to ensure that the shorts get their fair due, but it's a constant battle, supposedly.
Eight years ago, Ron started the AWN Oscar Showcase Tour, and although this was a lean year as far as director participation is concerned (those international travel schedules can be a nightmare to coordinate, I'm sure), but it's still going strong and he wants to make sure that these directors get the VIP treatment they deserve, if only for a couple of weeks.
Ron points out that, with the exception of the digital-formatted Logorama, all of the shorts will be presented in 35mm, which draws another gasp. It's the perfect audience.
The program starts with French Roast, followed by Granny O'Grimm's Sleeping Beauty, then The Lady and The Reaper. Three comedies, each with a streak of dark humor, each computer-animated. All three drew big laughs from the audience, and it's hard to predict if any of them will win over the Academy. French Roast seems to be the most "slight" of the three, and the Granny O'Grimm piece would be almost as funny if it were a spoken-word album, so I'd give the nod to Lady and the Reaper if this were a three-horse race. The comedic timing, the pacing, and strong use of pantomime make it a real standout.
Next up was Logorama, about which I'd heard nothing except that there might be some copyright issues that would prevent it from seeing a wide release. Which is like saying that there might be some problems if Godzilla were dropped into downtown Tokyo during rush hour. Without spoiling anything, I'll mention that about a half-dozen of the largest and most powerful corporations in the world are going to do everything in their power to supress this film if it wins the Oscar, which is probably reason enough for the Academy to recognize it.
Wrapping up the evening's program was A Matter of Loaf and Death, the latest Wallace and Gromit short. It's almost not worth the effort of writing about it, since the review for every Wallace and Gromit is exactly the same. Wallace is an idiot, Gromit tries to keep him from getting killed, but working together they manage to save the day, and Nick Park and the crew at Aardman turned in another brilliantly-timed, funny, enjoyable film. I'm tempted to file that away for future reference, since I'm sure I'll love the next Wallace and Gromit film, too, for exactly the same reasons.
Ron, Javier, Enrique and Raul take the stage again after Wallace and Gromit wraps up, for the ever popular post-screening Q&A. The questions run the gamut from the basics ("Where did you get the idea for this film?") to the esoteric ("How did the stereoscopic 3-D differ from 'traditional' 3-D?"), but the crew handled them all admirably.
Raul had the best short answers of the night, when asked how to describe the Spanish animation industry: "Crazy people." Followed quickly by, "we're doomed."
When asked about his next project, Javier shrugs and says, "L.A. Then holidays." Which is all he really needs to say. When you're off to Hollywood for a week of parties and you've already made history in your home country, I think you're entitled to a little downtime.
Andrew Farago is the Curator of San Francisco's Cartoon Art Museum and the author of the forthcoming Looney Tunes Treasury from Insight Editions.
Dan Sarto is Publisher and Editor-in-Chief of Animation World Network.
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