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Blog: Nuggets Ink
The Denver Post's Benjamin Hochman posts analysis, notes and more on this blog focusing on the Denver Nuggets.
MILWAUKEE — It's unclear whether they'll be having huevos rancheros in Houston, smoked meat in Memphis or otoro maki in Oakland, but the Nuggets do know their first playoff meals will actually be in Denver.
For the past two seasons, Denver has opened up at Oklahoma City and Los Angeles, but the Nuggets have locked up home-court advantage in the first round, with an opponent likely not determined until after all of Wednesday's games. The Nuggets (37-3 at home) host Phoenix in Wednesday's regular-season finale.
"I know teams don't like to play (at the Pepsi Center). Hopefully they'll struggle with the thought of playing there," Nuggets coach George Karl said after Monday's win in Milwaukee. "But we're still going to have to play good basketball to win a seven-game series. A seven-game series is the greatest test of competitive teams — try to beat a team four out of seven, I don't care how good they are. You've got to be smart, you've got be good and sometimes you've got to be a little lucky."
Because the Clippers won Tuesday, Denver's magic number is still one. In order for the Nuggets to secure the No. 3 seed, either they must beat the Suns or the Clippers must lose at Sacramento. If neither happens, the Clippers would become third and Denver would be fourth, hosting the Grizzlies in the first two games of the first round.
Regardless of their seeding, the Nuggets appear to be in a good place mentally heading into the playoffs, which will begin this weekend, likely Saturday. Yes, Kenneth Faried (ankle) is out and will be day to day heading into the postseason. And yes, Danilo Gallinari (knee) is out for the season. But this deep Denver team has won seven of its past eight games, the lone loss coming in overtime at Dallas.
And arguably most important, Ty Lawson is back to being Ty Lawson. He hit the game-winning shot at Milwaukee, finishing with 26 points.
"Ty coming back for three games (from his heel injury), the scripts of the first game getting his confidence, the second game playing better and tonight being the stud on the court, that's what we need," Karl said. "We know how valuable he is to us, and I think he's reasserted himself, and he's got a little but of his strut back, a little bit of his swag back."
The point guard — and Denver's leader in points per game and assists — said he's back to 100 percent.
"I feel good, man. I'll keep icing it and I'll be OK," Lawson said. "It's win or go home. I'm ready to play. I don't want a minutes limit or anything like that."
Benjamin Hochman: 303-954-1294, firstname.lastname@example.com, twitter.com/nuggetsnews


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Cetaphil Gentle Skin Cleanser, For all skin types,...
Cetaphil Gentle Skin Cleanser, For all skin types, 16-Ounce Bottles (Pack of 2)
Cetaphil best quality beauty products, skin care, face day and night creams, eye treatments, makeup, fragrance & perfume, hair and more! Softens As It Cleanses. CETAPHIL® cleanser was formulated for dermatologists as a gentle, non-irritating cleanser for even the most sensitive skin. Unlike soap, CETAPHIL is completely non-alkaline, non-comedogenic, and fragrance free. Soothes and softens as it cleanses, helping the skin retain needed moisture. Use for face, hands, and the entire body. Also an excellent cleanser for the delicate skin of babies.
Buy online the full selection of Cetaphil products.
Moisturizes as it cleanses
Rinses off easily, will not strip the skin of natural oils
Ideal for skin with conditions such as: Psoriasis, Rosacea, Acne, Diaper rash, Eczema, and dry skin
Gentle enough for children, teens, and adults
Cetaphil is manufactured by Galderma Laboratories, a major benefactor of the Dermatology Foundation, helping to fund critical dermatology research

subset: commoncrawl


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(By Rich Bieglmeier) It was a good week for insider purchasing ideas last week. Insiders at Cyberonics Inc. (CYBX) continue to gobble up shares despite the stock trading near a 52-week high, and that says something about the CEO's and VP of Quality's view of the company's future.
There were plenty of good candidates for review. But, we are going to focus on a $103 million – WOW – buy of MannKind Corp. (MNKD) by CEO Alfred Mann. A man of those means doesn't toss a hundred mill away on a hunch, and you can believe 'dat. iStock smells smoke.
[Related -Stock Upgrades And Downgrades: ANF, INTC, JPM, S, UAL, VMW, YUM]
Mr. Mann does have a history of making big buys. In the last two years, the CEO has committed $197 million to MNKD shares – WOW! Since June 2012, Mann has he gotten super-duper aggressive, buying $187.8 million of the $197M.
MannKind is a development stage biopharmaceutical company, engages in the discovery, development, and commercialization of therapeutic products for diabetes and cancer in the United States. Its lead product candidate, AFREZZA inhalation powder, an ultra-rapid-acting insulin therapy that is in late-stage clinical investigation for the treatment of adults with type 1 or type 2 diabetes for the control of hyperglycemia. The company also develops MKC1106-MT, an investigational cancer immunotherapy product, which is in Phase II clinical trials; and MKC204, which is in preclinical development stage for the treatment of malignancies and inflammatory diseases.
[Related -Stocks End Higher Despite Weak Data; Pandora Media Inc. (P) Plunges]
Fundamentals really don't matter for development stage biotechs. It's all about strategic partnerships, burn rates and FDA responses.
On November 13, 2012, MNKD signed an agreement with Colby Pharmaceuticals for exclusive worldwide rights to develop and commercialize disease-specific antigen compounds and intra-lymph node delivery technologies from MannKind's novel MKC1106 active immunotherapy programs, which are currently being developed for the treatment of melanoma, prostate, hematological disorders and other human cancers.
Under the terms of the deal, Colby will pay MannKind upfront and milestone payments linked to the development, approval and commercialization of products, with upfront and potential milestone payments of approximately $140 million total. MNKD will also receive tiered royalties on sales of products.
Prior to the Colby agreement, as September 30, 2012, management said, "We believe our existing cash resources, including the $21.9 million remaining available under our loan arrangement with The Mann Group, combined with proceeds received in October 2012 from the underwritten public offering, will be sufficient to fund our anticipated cash requirements at least into the third quarter of 2013."
The November alliance satisfies two of the three criteria above, a strategic alliance that provides enough money to burn until the FDA makes its decision.
According to many online sources, Afrezza was about to be approved at the end of 2010. In fact, an FDA employee, Chang Yi Liang traded on the "inside information" after reading the confidential approval notice on internal email.
The agency had a change of heart and issued a Complete Response Letter (CRL), asking for two additional trials. Most believe the additional trials would last between 1.5 to two years. The tiny biotech resubmitted its NDA on June 29, 2010 after discussing the CRL with the FDA. The 1.5 to two-year window is closing fast.
On the eve of its almost approval, MannKind Corp. (MNKD) reached more than $10 per share. Since then, well, all you have to do is look at the quote above to know what happened. Many feel the commercial approval for MNKD's inhaler could be a "game changer."
China's high and rising corporate debt problem and how best to address it has received much attention read on...
It's all about jobs now. Actually, it's always been about jobs. But the stakes are even higher—perhaps more read on...
In this current era of central planning, malincentives abound. We raced to frack as fast we could for the read on...
The Federal Reserve left interest rates unchanged yesterday, as widely expected. But the possibility of a read on...


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Retailers count on pulling in up to 40 percent of their annual revenue during the final two months of the year. So far though, the make-or-break holiday shopping season is disappointing.
While an increased number of shoppers were reported by many retailers, the National Retail Federation reports holiday sales numbers fell by nearly 3 percent from 2012 during the four-day weekend that began on Thanksgiving.
One week later, sales fell another 3 percent, according to data from ShopperTrak. And the number of shoppers plunged nearly 22 percent.
One place where holiday sales may be on the rise, though, is the local Christmas Tree Farm. The National Christmas Tree Association estimates that 25 million real tannenbaums were sold in 2012 with a retail value of more than $1 billion.
This year though, a fungus threatens production in the east, while a familiar guest "rubs trees the wrong way" in the Midwest. Josh Buettner explains.
America's first commercial Christmas tree farms sprouted on the east coast more than a century ago. But the family tradition of harvesting your own holiday flora remains strong across the country.
A few varieties of Christmas trees, like Douglas Fir and Scotch Pine dominate the market, but for the Frasier Fir, a resulting chorus of "Bah, Humbug" is trumpeting in the Tar Heel State.
Jeff Pollard/Christmas Tree Farmer.
"There's eleven years of work. Eleven years of work - gone."
Fungal pathogens have deteriorated soil quality in North Carolina, causing one farmer to lose up to eighty percent of his crop to Phytophthora root-rot. Frasier fir has long been a staple of the nation's number two Christmas tree-producing state. But once the soil is infested, "The Cadillac of Christmas Trees" is destined for the scrap heap.
While local producers bristle, researchers at North Carolina State University and elsewhere are investigating methods to engineer more rot-resistant trees. As a stop-gap measure, Christmas tree geneticists recommend farmers shift the source of their holiday cheer from the hills of Appalachia to the birthplace of Old Saint Nick himself.
John Frampton/ North Carolina State University
"There are a lot of nice characteristics about Turkish fir. It does make a pretty Christmas tree, but there are still a lot of things we're learning about the species."
According to the most recent Agricultural Census, North Carolina harvested more than 3 million Christmas trees in 2007. But the nation's industry leader, Oregon, chopped down more than twice that amount in the same time period. And while the Beaver State produces a slightly different type of tree than that of the Appalachians, experiments with Turkish Fir date back 30 years in Oregon. Phytophthora is seen as a threat to several classes of evergreens.
The heralded variation could be the savior of many a woeful Carolinian, but the tree comes with its own set of drawbacks. Turkish Fir tends to bud out earlier, making it susceptible to late frosts. And it suits the palate of a certain woodland creature whose population has exploded across the nation in recent years – deer.
John Frampton/North Carolina State University
"They'll walk by Fraser fir to snack on the Turkish fir."
But farmers like Jeff Pollard have decided to roll the dice on the alternative conifer.
Jeff Pollard/Christmas Tree Farmer.
"Good needle retention. Good, strong limbs. Soft. A good aroma. It doesn't smell as good as a Fraser fir though, I'll tell you that. But it's close."
While awaiting root-rot resistant solutions, like genetically modified Frasier Fir, close may be good enough to ensure a Merry Christmas in North Carolina.
Meanwhile, growers in Midwestern states have their own set of hurdles cultivating the renowned tannenbaum.
Gary Harman/Walnut Ridge Farm: "We need timely rains like fellas with corn and soybeans."
During the drought of 2012, Walnut Ridge Farm lost 80 percent of its Christmas trees near Indianola, Iowa. Those disastrous circumstances were documented by Iowa State University, which is conducting a five-year examination on fertilizer rates and application timing for Canaan and Frasier firs. And while root rot hasn't ruined the rich soil of the Hawkeye state, the buck definitely stops here.
Gary Harman/Walnut Ridge Farm: "This time of year, early part of the winter, it's buck rub. They take their antlers and just break the branches out of the trees, strip all the branches off the tree. Basically marking their territory and just wanting to be ornery, I think, is part of it."
While the Iowa deer herd has declined in recent years, the state Department of Natural Resources reports hunters have harvested over 50,000 deer this year alone. And as males mature, they employ some distinguishing methods to make their presence known.
Gary Harman/Walnut Ridge Farm: "A buck has picked out this tree to sharpen his antlers on, or just rub on, or just wants to be mean to me and ruin one of my trees that's about 5 plus feet tall. He's just taken his antlers and scraped and rubbed on the tree and peeled the bark off, broke the branches…And this tree will never make a Christmas tree."
Growers are to able salvage some of the mistreated crop. Wreaths and other crafts allow felled branches a second life as holiday decorations.
While deer have proven to be a persistent nuisance over the years, damage is actually down at Walnut Ridge Farm this season. Owner Gary Harman attributes the reprieve to the crop rotation in adjacent fields he rents out to local farmers. This year's soybeans didn't appear to whet the appetites of deer like grains.
Gary Harman/Walnut Ridge Farm: "They like corn better than soybeans. They move to where the cornfields are."
The Iowa DNR does offer limited assistance to farmers dealing with these kinds of pests, but Walnut Ridge has taken a more proactive approach.
Gary Harman/Walnut Ridge Farm: "Folks need to solve their own problem. And you don't need the DNR, you just need hunters that can do what they need to do and eliminate the population."
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Reviews for Mount & Blade: With Fire and Sword [Legacy]
An OK game, But that's itnoobboy191 | June 24, 2013 | See all noobboy191's reviews »
Compared to the other game, mount and blade warband, I feel this is incredibly lacking. The Graphics are the same as warband in my opinion, but due to gunpowder particles it can make a battle seem more thematic, like after a huge battle you can rise through the smoke to see the bodies of you're enemies on the floor.In terms of mechanics, wfas IS FAR BEHIND warband. Warband allows you to rule your own kingdom whenever you're ready. In wfas it only allows you to rule after a certain part of the storyline is passed, meaning you can't be the ruler you want to be until way into the story, and in some cases only for a set amount of time.Also marriage is completely unavailable unlike warband. What this game does get right is the suspense. The absolute greatest thing in this game is the suspense. Whether you are commanding your marksmen and having a full out musket firefight, not knowing if your shot will connect, and more importantly, if the enemy hits you first, or reloading your rifle as a horseman charges at you. In the end as a game, this is a very suspenseful and thematic game, but if you want the most bang for your buck, I suggest warband
Call of duty Fire and Sword.brenker99 | June 4, 2013 | See all brenker99's reviews »
This game is Like the previous ones but with Guns, that ruin the game. The guns ruined it. they just did. I got 50+hours in the other 2 games of the series and about 2 in Fire and sword. This game worth 6/10.
Fire and Sword!kalil | June 4, 2013 | See all kalil's reviews »
It appears as usual, by the company responsible for creating Mount and Blade (Taleworlds) make certain modders work to bring to market their own games. The result of this product among the most righteous of this award winning Turkish company. With Fire & Sword is the third game Taleworlds independent, which takes us back three centuries after the adventures in Warband. We went then contact the dreaded guns, taking popularity in sixteenth century Europe. This game, based first on a solid story mode allows us to immerse ourselves in a major way in the game. The story, based on a remarkable novel of a similar name to the game is complete, immersive 3 different aspects that, in no way detract from the freedom of action that characterize the series. However, this title suffers from a lot of "bugs" and errors that make the gaming experience will be seriously damaged. Sometimes it is impossible to advance the story because of these failures. On the other hand, the modder community has presented great interest in this game, so practically we found no modification to improve the decisions of With Fire and Sword. It is, in conclusion, a great game with certain faults that detract from gameplay. A new era to enjoy a new Mount & Blade.
Not What I Expectedcevana | May 26, 2013 | See all cevana's reviews »
Building off of Mount & Blade Warband, I had high expectations for WFAS. I can't say I'm not a little disappointed. I had heard much of how imbalancing the introduction of firearms was. Having played the excellent Napopleonic Wars, I had a hard time seeing how this could be a problem. I should have listened. There is very little as frustratingly out-of-your control by being one-shotted off of your horse by an enemy rifle. Rare, but since the consequence is defeat and capture, the steaks are too high. Thus, you end up trying to stay out of harms way and play commander. Too bad the introduction of firearms dilutes battlefield tactics as well. Mass guns and fire, rinse, repeat. Pros: -An interesting change of pace from the Medieval setting. If you already own the game (as part of a Paradox package for instance), it's still worth checking out. Cons: -Firearms are not implemented well, and disrupt the wonderful combat from Warband -Money is hard to come by and very integral to progress (I spent much of my time trading, rather than fighting) -Main quest breaking bugs can occur
For modders and tons of fundagozu | May 18, 2013 | See all dagozu's reviews »
Mount & Blade itself is an very good game but it hasn't been polished. The graphics of the game are not great, the game mechanics could be better but these things are minor issues when you think how much fun this game is when played. The singleplayer is ok but in the multiplayer the real fun begins, You can have up to 128 players on a map at the same time, other side attacking a castle and other defending it. I have had tons of fun in this game as a defender and as a attacker. I would suggest this game to people who want to have fun in the multiplyer and like playing medieval games. Of course you need to have original Mount & Blade to play this expansion. But the guns are nice add on to the game and create new battles that the original game does not have.
Not all too great.TheGrizzlyB | April 24, 2013 | See all TheGrizzlyB's reviews »
This game is just not that good. Now I'm not sure if it came out before or after Warband did, but it definitely isn't as good as warband. I'm also not really one for the singleplayer in M&B games so I can't really critique that, but I can say I don't really like the weapons in multiplayer. All in all I'd say skip this one if you're looking to play a M&B game, and instead get warband and the expansions. It is a lot better.
What happened?PM_DMNKLR | Jan. 29, 2013 | See all PM_DMNKLR's reviews »
What on Earth happened to this game? I had such high hopes for it, but honestly it just didn't live up at all. I checked it out once and only a few minutes was all I could take. The story and such aren't bad, but for me it's the 90's style graphics and movements that pushed me away from it. It's dropped tremendously in price compared to what it was released at, so perhaps $10 USD isn't too bad for it, but if you can wait for a good sale price to snag it and try it out, go for it.
Very similar to the previous Mount & Bladepanz3r88 | Oct. 28, 2012 | See all panz3r88's reviews »
Mount & Blade:With Fire and Swords is very similar to the previous title of the series: you are a mercenary that must travel though the land looking for fame and fortune. The main difference between this title and its predecessor is the presence of firearms: with these weapons the tactics you must use during fights are differents. The other aspects of the game remains unchanged: the graphic is really outdated and the open world gamplay is still fun, especially in multiplayer If you are a fun of this series, Mount & Blade is really a good game that can add a lot of new hours of gameplay
A glorified mod.Tholdor | Sept. 24, 2012 | See all Tholdor's reviews »
With Fire and Sword is based on a pretty decent Polish book by a Polish author about a part of Polish history (yeah, I know...). The game is presented as something new, which it is, but only partially. It's, basically, a modification of the original Mount & Blade with different map, new weapons (like firearms) and slightly different systems. Most of the changes are good, like guns and wagon forts, but some are pretty down-turning, like the inability to form a new kingdom. It would be a decent game, if mods weren't doing as well (or even better) than it. And for free. Obviously, to enjoy mods, you have to buy the original game or, preferably, the standalone expansion, Warband. Warband offers much more than WFaS, such as improved graphics, the opportunity to start a new kingdom, and a lot more modding potential. My suggestion is to buy Warband. This game is nice, but it offers nothing new after you've played some mods.
Good but Warband is better.zhack075 | Sept. 3, 2012 | See all zhack075's reviews »
I bought the Mount and blade collection and I was really curious. Well, I prefer warband which stay the best M&B. I disliked the era and the atmosphere of this game. In fact I think that firearms are little bit cheated and you can die easily by taking a shot from nowhere. I definitly prefer the Medieval era of Warband. Moreover, all the mods are released for warband and not Fire and sword. Buy it only if you want another mount and blade experience after Warband but if it's your first M&B, try warband first !
WARBAND!!!Dagexon | April 16, 2012 | See all Dagexon's reviews »
Please do not think that all the mount and blade games are bad, Warband is amazing and I'm sure that Mount and Blade 2 which is under way will be too but however With fire and sword does not live up to the standards of Mount and blade Warband. The singleplayer in Warband gave you a huge amount of freedom yet this game did not give you as much. For starters you can't even play as a women (not that I did in Warband though) which is sexist yet the game is set in a sexist society. This is what I did not like about the game, it tried to be more realistic and so it tried to focus a bit more on politics than before so to speak. Warband was set in a bit more of a fantasy land and was not restrained too much by reality yet didn't go over the top and have mythical creatures and all. Don't get me wrong, Warband is still rather realistic but it still isn't RESTRAINED by reality if your following me. We play a video game for fun, not for a realistic experience this is why with fire and sword failed. It was put in a time when firearms where heavily used and for purposes of reality keeps it that way yet for purposes of reality it made the fire arms so inaccurate which makes fights boring as the enemies are always using them but unable to hit you and you are unable to hit them. If you really are desperate to play a mount and blade game with fire arms then please get Warband and find a mod with them (trust me there are many fire arm mods) but don't get this.
Doesn't live up to expectationswengart | July 28, 2011 | See all wengart's reviews »
With FIre and Sword adds a new way of recruiting troops, a historical map, and firearms and grenades. I find the new recruitment system the most interesting additions. Instead of recruiting tens of villagers and then feeding them into the medieval version of the Somme hoping some of them survive long enough to vet you purchase mercs. It just seems much more realistic to me. Fire and sword also introduces you to a map of Eastern Europe to do battle on. Which is nice, especially for those of us familiar with the history of the area. Firearms are a double edge sword at best. They provide a new dynamic to the fighting, cavalry is no longer as effective due to the guns quickly killing horses and the player must be much more cautious since a bullet or two will kill you. But in the end even the new style of recruitment, historical map, and the introduction of guns and grenades doesn't make it worth the asking price. There are mods out for both Mount & Blade and Warband that do what this game does better and cheaper.
Worse than Previous Games.IganX | July 22, 2011 | See all IganX's reviews »
M&B: With Fire and Sword was disappointing compared to M&B: Warband. This game has less options, more glitches and bugs, is smaller and adds gunfire. This last feature makes the battles depend less on skill and more on luck, making large scale battles look worse than before. The campaign is fine, and the graphics have some small improvement, but being based on the novel hasn't made this game better than the previous. I loved the sandbox taste M&B: Warband had, which seems to be lost in this more linear game. Overall, the game is still fine, but loses a bit compared to the previous sequel of M&B.
Disappointingsteamisbetter | July 3, 2011 | See all steamisbetter's reviews »
With Fire and Sword is Mount & Blade with guns. Guns replace crossbows and are in many ways similar. They do more damage than bows, take forever to reload and don't lose accuracy when in aim mode. All guns in the game fall into two categories: muskets and pistols. Pistols are less accurate and do less damage, but are faster to reload and, if on foot, don't require you to stand still during the reload animation. The other less obvious difference is that pistols are single-handed weapons, and while there's sadly no dual-wielding in this game, it means that the "blind spot" for horseback shooting is on your left side, as opposed to two-handed ranged weapons where the blind spot is to your right. Also, you can use your gun as a last resort melee weapon, but at that point you're probably dead already. Old throwing weapons have been replaced with hand grenades. This is a good change, as grenades are very fun to use and throwing weapons in previous game were subpar to say the least. Grenades do splash damage and have a knockback effect. They are however very expensive and only come in limited quantities, so you can't really play as a grenadier and simply spam grenades. Other equipment is still there, but they are now less useful and commonplace. Bullets simply do much more damage and travel very fast. Horses tend to go down very quick under gunfire. Getting within melee range is quite tough, especially against pistol users. Bows are a rare sight in multiplayer, the only advantage of bows is their faster rate of fire, but you can always carry multiple guns and simply switch between shots, then hide and reload. Shields are virtually useless. Ability to kick is still there and it is still used almost exclusively by griefers. A patch also added crouching, which makes you a smaller target while you reload your gun, as if the game didn't have enough campers already. I didn't find the multiplayer maps very interesting. Just generic battlegrounds without charm of Warband maps. Maybe it's because I spent so much time in one spot firing shots at enemies that I didn't really get to explore the rest of the map. Or maybe it's because the maps were designed for that kind of gameplay. The game is realistic, but not in a good way. There are 5 historically accurate factions and they aren't as diverse as the factions in previous games. The game takes place in eastern Europe, which means the maps consist almost entirely of grassland and small patches of forests. There's no snow or desert environments, and only a small amount of rough terrain. You also can't start your own kingdom, you can only choose to become a rebel but it's not really the same. When the game was released, you couldn't play as a female character, but this feature was later added in a patch. I really don't see how the game benefits from realism. It's based on a Polish novel with the same name, so I suppose some may find it interesting, but I had never even heard of the novel before. Ultimately, I think the biggest problem is that they are still using the same old game engine. It excels at mounted combat, directional attacks and blocking. Not long range sniper fest gunfights. The UI has always been a bit clunky and the addition of main quests and real storylines makes in even more obvious. Also, I think there are some big balance issues with some of main quests. One of them has you breaking out of a prison, all you have is a melee weapon and you're up against gun users in long corridors with no cover. I had to lower the difficulty to complete that one. If you fail, the game kicks you back to main menu. That is not something you'd expect in a sandbox game. The engine is getting outdated and not suitable for this kind of gameplay. I think the developers too realize this. But as with the previous games, the true potential of the game is yet to be seen, just wait while modders start to really get their hands on it. Overall, I didn't find the game as enjoyable as the previous ones, but I still got 44 hours of enjoyment out of it shortly after release. I'd strongly recommend Warband over this one.
Average gamepngohuy | June 29, 2011 | See all pngohuy's reviews »
Mount and Blade : Fire and Sword is the third game in the Mount and Blade series. As this game released, I bought it via Steam. In this version, there are both good and bad things. The good things are : basic combat is same as the Warband version, it is now more risky and fun. it will have more fun when playing with other players. The bad things are more than the good ones : many old features are not available in this game : less options in this game, for example no longer can you marry a noblewoman in order to become a noble, you can't create your own kingdom (which is the best part of Mount & Blade). Moreover, the ability to play as a female character is gone too. Some of the locations look nice, while others look terrible. The last thing : if anyone is new to Mount and Blade series, he should purchase the Warband version first. This is the best one in the series in my opinion.
Disappointinggege_le_keke | May 9, 2011 | See all gege_le_keke's reviews »
I love M&B, especially Warband, so I was excited about this new episode. Sadly, this game has many flaws. First of all, it is kind of buggy, but I'm sure that some patches will sort out this little problem. What really annoys me is that the firearms are too realistic. These one shot one kill weapons make the battles really slow because of the time needed to reload. The map isn't very interesting, and the name of the cities are impossible to remember. However, I really enjoyed the historical background. The recruiting system is weird, I really prefer the previous one. I think this game could have been a M&B: Warband mod instead of a full game...


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December 1998
In one study, which included people treated with Highly Active Anti-HIV Therapy (called HAART) very early after initial infection with HIV, virus capable of reproducing was found in every individual treated despite the fact their HIV levels were below the limit of detection with currently available tests. The apparent cause of this is the presence of a population of resting T-cells which are infected by HIV. While in their resting state, the cells provide a near perfect harbor for HIV. The immune system doesn't recognize them as infected cells because they aren't expressing virus or the surface markers that would indicate they are infected. The immune system can only detect the presence of HIV when a cell is actively producing new virus, which identifies the cell as infected. Similarly, anti-HIV drugs can play no role with resting cells for the same reason. Drugs can only interfere with the production of new virus or the infection of new cells by active virus. Therefore, they can't do anything when the virus is resting inactive inside a cell. These resting, or quiet cells, are believed to be the major reservoir of HIV infection.
These cells can persist indefinitely, and virus lurking within them can rekindle active HIV infection. When and if these cells become active, they can begin producing virus. This reservoir of resting cells is believed to be one of the major barriers to completely eliminating HIV from a person's body.
Researchers who are attempting to achieve eradication (e.g. the complete elimination) of HIV are now planning to test different methods of converting these resting T-cells into active cells. Once activated, these cells should be vulnerable to the immune system and to antiviral drugs, just like other cells. Interleukin-2 (IL-2 or Proleukin®) stimulates resting cells, thus exposing both virus and cells to the effects of anti-HIV drugs as well as the immune response against HIV. Using IL-2 therapy may help to decrease or eliminate this hidden pool of virus.
In August, Dr. Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID, the institute which funds the majority of AIDS research efforts worldwide), presented new findings from an exploratory study of IL-2 used in combination with potent anti-HIV therapies.
At the International AIDS Conference in Geneva, Dr. Fauci and his colleagues raised the question of whether people treated with HAART plus IL-2 are any different from those treated with HAART alone. Specifically, they wondered whether IL-2-treated patients would have similar or different levels of the resting, infected T-cells compared to people on HAART alone.
After Geneva, they conducted a study to answer this question. The study compared two groups. The first consisted of 13 people with viral load levels below the limit of detection for 6 months or more using a very sensitive test (limit of detection 50 HIV RNA copies per ml). All were participating in NIH studies of HAART and IL-2. The second group recruited volunteers taking a HAART regimen for 6 months or longer and who had viral levels below the test's limit of detection. The two groups were very similar with regard to baseline CD4+ cell counts and viral load, length of prior therapy with HAART and other characteristics.
The research team then used sensitive tests to look for the presence of HIV DNA inside resting T-cells capable of reproducing (replication competent virus). Initially, they looked at about 10 million cells per individual. This has been sufficient in other studies to find infected cells and replication competent virus in virtually all HIV-infected people. Replication competent virus was readily found in resting cells in all 13 people who received HAART alone. In six people who had received HAART in combination with IL-2, however, the researchers could not detect replication competent HIV or latently infected cells.
Five of the six individuals who had been receiving the IL-2-containing regimen and had no detectable replication competent virus were studied further. Even more sensitive tests were run by searching through greater numbers of cells, more than 300 million cells from each person. Despite this intensive unprecedented search for the virus, researchers were still unable to find replication competent virus in three of the five individuals. To make sure this wasn't a temporary phenomenon and recheck their accuracy, the tests were repeated several weeks later in all six patients. The results were nearly identical, except this time the researchers searched even further, through more than 400 million cells, without finding HIV in the same three people.
Although virus was not found when looking at more than 300 million cells, it does not necessarily mean that virus has been completely eliminated from these people. To make such a claim, Fauci said one would technically have to examine every cell in the body, and no one is likely to ever do that. An even more intensive search is underway now looking for virus in deeper immune compartments, such as the lymph tissue. The next step, underway now, is to sample lymph tissue from the rectal mucosa and to examine spinal fluid.
The relevance of these observations might only be understood when or if these few people choose to stop their anti-HIV therapy. If there are still extremely small amounts of virus somewhere in the body, stopping HAART might allow the virus to re-establish itself and rekindle the fires of HIV disease. The real question is not whether HIV is completely eradicated, but whether there is enough of it still present to rekindle an active state of infection.
There is already some indication that full eradication is not necessary to prevent recurrence of active infection. For example, more than 10 patients in the US and Europe are currently being studied who have already gone off therapy on their own choosing. Whenever researchers have looked, these patients have measurable levels of replication competent virus -- unlike those in Fauci's new study. Yet these 10 people have been off of all anti-HIV therapy from 3 to 18 months without experiencing a return of measurable viral load. Fauci's patients would seem to have at least as good a chance as these people of successfully stopping therapy.
Preliminary results from this study are extremely encouraging and go beyond any data reported elsewhere. Still, another larger study needs to be designed quickly to confirm the findings. While in laboratory studies IL-2 appears to stimulate HIV replication, it may be that when used with anti-HIV therapy, IL-2 may help flush the reservoir. That in turn may expose virus to the effects of anti-HIV therapy as well as the immune response against the virus and then ultimately assist in more greatly decreasing the amount of HIV in the body.
IL-2 studies in people with HIV show that the therapy has the most profound and dramatic impact on CD4+ cell count than any therapy in the history of AIDS research. Numerous studies have confirmed the ability of IL-2 to effect pronounced CD4+ cell increases over and above what is realized with anti-HIV therapy alone. Thus far, lab studies suggest that CD4+ cells increased as a result of IL-2 therapy appear just as normal and useful as cells generated after successful HAART therapy.
It remains unclear if these increases will contribute to decreases in the risk of developing HIV-related infections or prolonged survival, though there seems to be no reason to expect otherwise. A study to answer this question is being planned and will hopefully begin to enroll early next year. A component of the trial, being conducted through a community based clinical trial network (CPCRA), is currently opening in sites throughout the US. For more information about trial sites, call 1-800-TRIALS-A and ask for CPCRA IL-2 study sites in your area.
While the growing bulk of results from IL-2 studies are increasingly encouraging, those contemplating becoming involved in an IL-2 study should be aware the therapy can be hard on patients. The most common side effect associated with IL-2 is mild to severe flu-like symptoms. Nearly everyone using IL-2 can expect to experience this side effect during the time therapy is taken (e.g. the 5-day course of IL-2).
IL-2 therapy is not taken every day. It is cycled and taken for 5 days in a row, every 8 weeks. Therapy is delivered through injection directly under the skin (subcutaneous). Time between cycles may be extended in IL-2 recipients who realize pronounced and prolonged CD4+ cell increases.
In a recent report on the long-term follow up of people in a NIAID study of IL-2, the average duration between cycles to maintain CD4+ cell counts at about 1,200 was 1 year. However, the individuals in this study had very high CD4+ cell counts (about 600) to start. This kind of immediate response is not expected among people who initiate IL-2 with lower CD4+ cell counts, where increases may take longer to realize. Sustaining those increases may require continued and frequent dosing.
For more information on IL-2, call Project Inform's National HIV/AIDS Treatment Hotline and request the IL-2 Fact Sheet.
HIV/AIDS Resource Notes
National Trials Hotline. The AIDS Clinical Trials Information Service provides information on federally sponsored studies (and many others) open to enrollment nationally. Call 1-800-TRIALS-A (1-800-874-2572). 800-AIDS-012 TTY/TTD serves the deaf and hearing impaired. The service also provides free copies of the AmFAR Treatment Directory, which also lists studies conducted by private industry.
National AIDS Hotline.This Hotline operates 24 hours a day and provides referrals to local services throughout the U.S. and information about a wide variety of non-treatment related topics. Call 1-800-342-AIDS (2437) . Spanish-speaking operators are available 8am - 2am EST at 1-800-344-SIDA (7432) . For the deaf and hearing impaired, call 10am - 10pm EST at 1-800-AIDS-TTY (243-7889).
STEP Perspective is a newsletter produced by the Seattle Treatment Education Project. Call 1-800-869-STEP for information on their publications.
WORLD is a newsletter for, by and about women facing HIV disease. WORLD strives to break the isolation of HIV+ women by providing a forum for communication and information of interest to women. For more information call 1-510-658-6930.
AIDS Treatment News (San Francisco) 1-800-873-2812.
Treatment Issues (Gay Men's Health Crisis, New York) 1-212-337-1950
Back to the Project Inform Perspective December 1998 contents page.


text: When the League learns that there's a giant creature using the moon as a giant monster incubator they do everything in their power to keep things stable. But as the gargantuan beast starts to hatch the very Earth itself is threatened with certain doom! And when a stormy old foe uses the opportunity to create chaos the Justice League finds themselves buffeted by the howling winds of fate!


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Safe soy ice cream!
I have yet to try this, but I just saw it at my local health food store:
Temptations Premium Non-Dairy Frozen Desert
From their website:
"All of our products are manufactured in on dairy-free, egg-free, peanut-free, and treenut-free equipment in a plant that is ALSO dairy-free, egg-free, peanut-free, and treenut-free.
It is SO important to us that our allergy-aware customers feel safe when eating our products. Everyone who works here is vegan, so that means no one is even bringing dairy or eggs into the plant for lunch... and we're all allergy-aware ourselves because we've had this special vegan diet for over 10 years each.
We use GLUTEN in two of our products (CHOCOLATE CHIP COOKIE DOUGH and PEACH COBBLER), but they are not made on the same production equipment. Celiacs and gluten-intolerants can eat the remainder of our products without worry."
Sounds pretty impressive! They are based in the Chicago, IL area, so I don't know how far they distribute. I am in NY state. I'll let you know how it is when I try some!
Thanks for posting! We've had a really hard time finding a frozen dessert free of milk, egg and nut contamination! I hope I can find them here on the west coast - I will certainly be on the look out for this now!
Wow! This sounds great. While I am not allergic to dairy, we do keep kosher at home. I would love to try some. I am in CT.... do you know where we can get some?
Unfortunately, their website does not have a list of stores where you can find it. I saw it at our local health food store (it's not a chain store). If you want to contact them to ask, their # from the website is 630.629.9667, and their email is [email]firstname.lastname@example.com[/email] .
Hope this helps!
Greeting From Chicago Soydairy, makers of Temptation soy "ice cream"!
Its amazing where you find people talking about our product! It wasn't all that long ago that we were making this stuff in a basement for a few stores in town. Now we have national distribution (almost) and people we don't know are talking about us. Very cool, and I thank you all for showing interest.
For those who are interested in trying this stuff, I want to let you know that we will be in Wholefoods all around the country very soon (End Of Febuary hopefully). Otherwise, it is available at Heatlh Foods stores in the Midwest, and is now available on the east coast. We just got distribution to the east coast so we are not in many stores yet. If you live on the east coast and want to try the best allergy free soy ice cream of the planet, please print off the following info from our website and give it to your favorite grocery and ask them to get it in.
Thanks for your interest and help.
Co-founder Chicago Soydairy
I finally found their products at a Whole Foods in Massachusetts. My PA daughter loves the chocolate and cookie dough flavors.
We finally bought some too, and it's really quite good! None of that weird gummy after-taste. We've just stuck with 'conventional' flavors so far, but we're going for some of the other ones now [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img]
Thanks for leading us in this direction!
We just picked some up at whole foods. DD loves it. She had her first "ice cream cone". DH and I tasted it too and it is really good. I am impressed.
My 5-year-old son who is allgeric to egg, peanuts and dairy told santa this year that he wants ice cream for Christmas!!!
Luckily, we live in the CHicagoland area so this product was available in out local Wholefoods (local is about 80 miles rt). But in a sleigh, it's much quicker!!
When he woke up on Christmas morning, there was a note on the table telling him to look in the freezer. It was FILLED with every flavor of Temptation ice cream. You should have seen his face light up!!
And his parents like it just as much as he does!
I really wish we could get it at Trader Joe's, though. It's REALLY expensive.
This "soy" Cream is AWESOME! in CT they cary it at New Morning in Woodbury as requested by us and also at whole foods in west hartford. By far the best vegan ice cream ever! My daughter LOVES it!
( I posted here a few years ago and now I can't remember my old password)
We just discovered this fairly recently as well, and my DS goes crazy for it! We bought an ice cream maker last summer, which is great, but sometimes we just don't have the freezer space for that big container or the time/energy to make it ourselves! This has been such a fabulous alternative!
Wish we could have access to all their flavors, but we'll take what we can get.
Yes, I do agree it's kinda expensive.
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Stay on top of your allergy with the latest news, lifestyle tips and recipes.


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Silver Wheaton Corporation Stock Downgraded (SLW)
TheStreet) -- Silver Wheaton Corporation (NYSE: SLW) has been downgraded by TheStreet Ratings from buy to hold. The company's strengths can be seen in multiple areas, such as its revenue growth, expanding profit margins and good cash flow from operations. However, as a counter to these strengths, we find that the stock has had a generally disappointing performance in the past year.Editor's Note: TheStreet ratings do not represent the views of TheStreet's staff or its contributors. Ratings are established by computer based on metrics for performance (which includes growth, stock performance, efficiency and valuation) and risk (volatility and solvency). Companies with poor cash flow or high debt levels tend to earn lower ratings in our model. NEW YORK (
-- Written by a member of TheStreet Ratings Staff
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- SLW's revenue growth has slightly outpaced the industry average of 3.3%. Since the same quarter one year prior, revenues slightly increased by 3.1%. This growth in revenue does not appear to have trickled down to the company's bottom line, displayed by a decline in earnings per share.
- The gross profit margin for SILVER WHEATON CORP is currently very high, coming in at 85.20%. Regardless of SLW's high profit margin, it has managed to decrease from the same period last year. Despite the mixed results of the gross profit margin, SLW's net profit margin of 64.84% significantly outperformed against the industry.
- Net operating cash flow has slightly increased to $165.61 million or 1.09% when compared to the same quarter last year. Despite an increase in cash flow, SILVER WHEATON CORP's cash flow growth rate is still lower than the industry average growth rate of 43.84%.
- The company's current return on equity has slightly decreased from the same quarter one year prior. This implies a minor weakness in the organization. In comparison to the other companies in the Metals & Mining industry and the overall market, SILVER WHEATON CORP's return on equity significantly exceeds that of the industry average and is above that of the S&P 500.
- In its most recent trading session, SLW has closed at a price level that was not very different from its closing price of one year earlier. This is probably due to its weak earnings growth as well as other mixed factors. Turning toward the future, the fact that the stock has come down in price over the past year should not necessarily be interpreted as a negative; it could be one of the factors that may help make the stock attractive down the road. Right now, however, we believe that it is too soon to buy.
-- Written by a member of TheStreet Ratings Staff
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text:
May 5, 2016
Snow fell briefly in parts of North Carolina, but didn't linger Saturday after below-freezing temperatures descended on most of the state, breaking at least one record. A reading of 20 degrees in Asheville broke a record of 22 for April 7. The cold front that moved into the state left up to 8 inches of snow in high elevations of Avery County. There was one-and-a-half inches in Asheville, which melted except in shady spots. The Highway Patrol said the snow led to more than 90 accidents in Buncombe and Henderson counties, where road crews spread salt and sand as forecasters called for more cold weather through the weekend. A dusting of snow reached as far east as Cumberland and Vance counties. About point-13 inches of precipitation (a mix of rain and snow) was recorded at Raleigh-Durham International Airport.
Lows across the central portion of the state Friday night and Saturday morning were in the 20s in many places. The cold weather caused concern among fruit growers and gardeners. The cold also was responsible for cancellation of a Kinston Indians baseball game and snow forced cancellation of a baseball game at Mars Hill College in Madison County.
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About Us
Michener and Skinner Libraries hours
Parking and driving directions to Michener and Skinner Libraries
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Contact information for faculty, staff, and departments
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Find the librarian in your subject area.
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Discover what's new at the University Libraries.
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Donations help the UNC Libraries ensure student success and support faculty research.
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Information on membership, volunteering, and Friends' sponsored projects and events


text:
May 5, 2016
Tuesday Feb. 3, 2009
COLUMBIA, S.C. (AP) -- South Carolina has announced that Johnson "Jeep" Hunter is joining coach Steve Spurrier's staff.
The school announced Tuesday that Hunter will serve as tight ends coach and assistant special teams coordinator. He'll replace Ray Rychleski, who spent last season as special teams coordinator and tight ends coach.
Hunter last coached in 2007, the second of two seasons with Georgia Tech. He's also coached at Memphis, Eastern Kentucky and Chattanooga.
Hunter is the last of five new assistant coaches hired by Spurrier since the regular season ended. The Gamecocks also hired a new strength coach in Craig Fitzgerald.
(Copyright 2009 by The Associated Press. All Rights Reserved.)
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text:
Seneca Foods Completes The Acquisitions Of Unilink, LLC And Lebanon Valley Cold Storage, LP
MARION, N.Y., Aug. 10 /PRNewswire-FirstCall/ -- Seneca Foods Corporation (the "Company") (Nasdaq: SENEA, SENEB) announced today that it has purchased the assets of Unilink, LLC from Pennsylvania Food Group, LLC and has purchased Lebanon Valley Cold Storage, LP and its subsidiary, Lebanon Valley Cold Storage, LLC, from its partners. These businesses, based in Lebanon, Pennsylvania, primarily sell frozen fruits and vegetables in the packaged private label retail and food service channels. "We believe that these operations are a complementary fit with our frozen vegetable business which is primarily based in the Midwest. It will give the Company an eastern distribution point for private label retail and food service frozen vegetables, with an experienced workforce, solid book of business and potential for growth in the future," stated Kraig Kayser, Seneca Foods' President and CEO. "On behalf of the entire Seneca team, I welcome them to the organization."About Seneca Foods Corporation Seneca Foods is one of the country's largest processors of canned fruits and vegetables with manufacturing facilities located throughout the United States. Its products are sold under the Libby's, Aunt Nellie's Farm Kitchen, Stokely's, READ, and Seneca labels as well as through the private label and industrial markets. In addition, under an alliance with General Mills Operations, LLC, a successor to the Pillsbury Company and a subsidiary of General Mills, Inc., Seneca produces canned and frozen vegetables, which are sold by General Mills Operations, LLC under the Green Giant label. Seneca's common stock is traded on the Nasdaq Global Stock Market under the symbols "SENEA" and "SENEB". Forward-Looking Statements Statements that are not historical facts, including statements about management's beliefs or expectations, are forward-looking statements as defined in the Private Securities Litigation Reform Act (PSLRA) of 1995. All forward-looking statements involve risks, uncertainties and contingencies which may cause actual results, performance, or achievements to differ materially from anticipated results, performance, or achievements. Factors that may cause actual results to differ materially from those in the forward-looking statements include those set forth in our filings with the SEC, including the disclosure under the heading "Risk Factors" in the Company's Annual Report on Form 10-K. There can be no assurance that the acquisition will close on the expected schedule or that the acquisition will be consummated at all. We are under no obligation to update or alter our forward-looking statements, whether as a result of new information, future events or otherwise. SOURCE Seneca Foods Corporation
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text:
Jean on the Job
- Details
- Published on Tuesday, 03 September 2002 20:22
- Written by Jean Hollands
Executive recruiting: show time to slow time
The fascinating work of retained search is suffering a little. As compared to two years ago, when the phones rang incessantly thanks to companies looking for new executives in the skimpy world of the currently unemployed or underemployed, searchers are now straining to find the right executive for the few slots open.
The good news is that organizations are still looking for productive officers for their companies. Some of the "iffy" search companies are having to close their doors, and some of the individual consultants are looking for new ventures. This means that those still in business are solid, dependable and honest companies with enough moxie and durability to weather this drought.
Matchmaking of all kinds can be fascinating work. In Japan there is actually a titled executive called the "matchmaker." He is charged with matching up eligible employees within a company for possible matrimony. Keeping the family within the company sounds pretty good to me, but of course we cannot do that here in the United States.
Our corporate recruiting companies, the professional employee version of matchmakers, find the right CEO type for the right job.
At this moment in time, the most popular position to place is the sales professional. Everyone wants more salespeople - not accountants, marketeers or manufacturing gurus, just someone who will go out there and find the business.
If you are in the sales world, go for it. If you are not, and you still want to be gainfully employed, learn how to sell. It is not innate; it is a learned skill.
Jean A. Hollands, CEO of Growth & Leadership Center, author of the book "Same Game Different Rules - How to Get Ahead Without Being a Bully Broad, Ice Queen or 'Ms. Understood'," was voted Business Woman of the Year in 1986 and 1996. Write to GLC, 1451 Grant Road, Mountain View 94040.


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African Helix Stitch Video, Part 1
Part Number:VIDEO-0032
This stitch was a request, so I taught myself so that I could teach you! African Helix is a fun stitch that creates a tube-like structure. This week we will only learn the stitch. We will complete the bracelet in Part 2 of this series.
Tips and Tricks:
- One tube of each seed bead color should be plenty for a bracelet, but if you want to extend this to necklace length, plan on getting 2 tubes of each color.
Karla Schafer, Auntie's Beads Designer
Materials and Supplies Used in This Video:
3 Review(s)
Customer Reviews
Easy pattern even for a first try!
I worked this pattern on my first attempt without any problems. I like the fact that when you pull the thread tightly you will hear a click as it tightens. Keep up the good work on your videos Karla! You have clear, easy to follow videos making the complicated looking projects easy to complete.Reviewed by: Shirley from Texas. on 1/3/2011
Fun but time consuming
I worked on this project on and off for 3 weeks. I used 10/0 because I couldn''''t find 11/0. I also used a regular sewing needle because I was impatient to start. It worked but the beads kept getting stuck over the eye. Eventually I finished and it turned out really fabulous. Now I have the right size beads and proper needle so it''''ll be much faster. Try it, you''''ll love it.Reviewed by: Duane from Jacksonville, FL . on 10/12/2010


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The Big Book of Hockey Trivia
Greystone Books, a division of D&M, 2005 - Sports & Recreation - 577 pages
As much fun as being on the ice but easier on the teeth, hockey trivia guru Don Weekes's latest collection is a cool treat for fans of all ages. Who was the first NHL player to torpedo his million-dollar contract? Which player scored the fastest hat trick on one power play? Who was the only goalie to score a power-play goal? Weekes cherry picked more than 800 of his most compelling trivia questions and records to create this vast and quirky compendium. Irreverent, captivating, and even bizarre, these amazing stories, historic milestones, and informative stats capture the essence of the game today. It's all here, the good, the bad, and the ugly, in a riveting, jam-packed read that hockey hounds will devour from cover to cover.
What people are saying - Write a review
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text:
Aug. 26, 1999
Sacramento, Calif. - In an attempt to become just the second collegiate gymnast this decade to make the U.S. National Women's Gymnastics Team, UCLA senior Heidi Moneymaker (Santa Rosa, CA) fell just .087 short, placing 21st at her first-ever USA Gymnastics Championships.
The 21 year-old Moneymaker, who competed under a more difficult code of points in this meet than she does in collegiate gymnastics, recorded a 34.75, less than a tenth of a point out of the Top 20. The U.S. National Team consists of the Top 20 finishers at the Championships. Moneymaker's top-scoring event was a 9.075 on vault, the event on which she is the reigning NCAA champion. She began the meet by scoring an 8.675 on beam. Her other scores were 8.425 on floor and 8.575 on bars.
Kristen Maloney won her second consecutive national title with a score of 38.687.
Despite not making the Top 20, it has been quite a successful summer for Moneymaker. In July at the World University Games, she was the Top U.S. competitor, placing ninth in the all-around during team competition and 16th in the all-around finals. Her scores at the World University Games allowed her to petition for a spot in the USA Championships, where she was the only collegiate gymnast to compete.
Moneymaker, an eight-time All-American and last year's Pac-10 and Region 1 all-around champion, will return for her senior season at UCLA. The Bruins will begin competition January 7, 2000 at the SEC Challenge in Georgia.


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- Jul 30:
- Sinkhole repair near Leadville progresses, one lane reopens Monday night
- Jul 19:
- Road crews face another sinkhole, this time on I-70 near Idaho Springs
- Jul 18:
- CDOT chooses contractor, sinkhole repair begins Wednesday
- Jul 16:
- Sinkhole forces Courage Classic route change
- Jul 13:
- U.S. 24 sinkhole "crumbling into the abyss" near Leadville
- Jul 11:
- Sinkhole caused by Leadville train tunnel closes U.S. 24 indefinitely
- U.S. 24 sinkhole near Leadville determined to be old railroad tunnel
The Colorado Department of Transportation has opened one lane of U.S. 24 north of Leadville after a 45-foot deep sinkhole that opened up after heavy rain Monday morning closed the highway.
CDOT crews decided to close the highway at mile marker 165 south of Red Cliff as a safety precaution while they determine the extent of the sinkhole's damage, according to a CDOT news release.
Stacey Stegman , a CDOT spokeswoman, said the sinkhole measures 20 by 30 feet and is 45 feet deep .
"We need to know how much damage is under the road before we start repairing it," Stegman said. "Until we get a handle on how far down it goes and the damage around it, we won't know how long it will take to repair."
Stegman said if heavy rains continue as they have over the past few days, it's likely the sinkhole will continue to grow.
CDOT recommends motorists use Colorado 91 as an alternate route until the stretch of U.S. 24 is reopened.
Sarah Simmons: 303-954-1210, firstname.lastname@example.com


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AsteriskNOW 1.5 Beta Available, More Coming Soon
Last month at AstriCon we announced the upcoming launch of AsteriskNOW 1.5, a new version of Digium's award winning software appliance that incorporates the FreePBX graphical user interface. Today I'm very pleased to announce that the first beta release of AN1.5 is available on asterisknow.org.
For those of you not familiar with the product, AsteriskNOW is a free Linux install image (.iso file) that reduces the process of building an Asterisk-based system to "burn, boot and run". Simply download the .iso image, burn it to a CD, drop the CD into your soon-to-be Asterisk computer and boot. The integrated … Continued


text:
Writing in Vonnegut's World
On training wheels, fan fiction, and stories in the cave.
If these are the end times for literature, then we must be traveling in circles, for the death of storytelling looks an awful lot like its birth. The novel itself isn't all that old. Sure, we can find a handful of examples going back thousands of years, but you have to stretch your definition of novel the further back you go. Really, the idea of an immutable and unchangeable text dates only to the printing press. Before that, every scribe tasked with producing a tome thought he was an author. Like movie producers dabbling with plot, it was difficult for the hand-copiers of text not to make a tweak here or there. Books were ever-changing. Stories evolved. And that was the way things were until Gutenberg's time.
Fast forward to 2012, where 1 out of every 5 books sold was part of the 50 Shades of Grey series. Originally a work of Twilight fan fiction, the monumental success of 50 Shades of Grey turned a spotlight on the shadowy world of fan-generated literature. Soon, publishers were seeking out other popular works of fan fiction and signing authors to mega deals. Then Amazon announced its Kindle Worlds program, which commercialized fan fiction and opened up licensed worlds for exploration. To purists—who mix a love of history with a thin understanding of the past—the sanctity of the written word was in jeopardy. It was raining frogs. The volcanoes were angry. These lovers of the very modern novel clamored for a return to our roots. And yet—that is precisely where we are heading.
Although no written account remains (writing wasn't invented yet), it is safe to assume that fan fiction was invented about five minutes after the first story was told. A cave echoed with a riveting account of a great beast felled, and someone in the audience was already thinking of an improvement or a twist. These twists became part of the story as it moved through time and space; original storytellers relied on their imperfect memories, which promoted the flow and evolution of tales and allowed each one to be shaped to its audience. The oldest stories we know of, like Homer's The Odyssey, were likely written by the collaboration of many and were the end result of thousands of varied retellings.
Lovers of the new and immutable novel may fear the end times, but ironically the end times themselves were a work of fan fiction. The four Gospels were written well after the times they describe, and each has its own take on similar events. (It used to bother me that the Gospels disagreed on so much. But then I discovered Batman comics and saw how often the Caped Crusader's origins and backstory also changed over time.) Shakespeare made a career out of fan fiction. Wealthy patrons would request a new stab at a familiar story, and the Bard would comply. Or he would draw upon historical facts and people to make fiction from the real.
How is historical fiction, for that matter, different from fan fiction? After all, any hack can borrow the known world—whether historical or contemporary—and write a quick masterpiece. But of course it isn't so simple. The writing is still the hard bit. Whether an author takes as their inspiration the life of Henry VIII or their own traumatic childhood or Batman's traumatic childhood, they still have to fashion an engaging plot, realistic dialog, and pleasing prose. That's the challenge, not the original idea. Ideas are cheap. Stories are dear.


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help me with my dates
on october 7th i had a one night stand with a friend of mine, shes given birth today 16th july but im finding it hard to get her todo a paternity test, shes not 100% hes mine but from those dates what is the likelihood? brutally honest answers only please
Posted: 07/16/2013 by a BabyCenter Member
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her due date was today 16th of julyposted 07/16/2013 by neil81
Likely But did she say she went over her due date? According to the baby calculator by conception date she was due June 30th. They don't usually let women go over two weeks past due date, but if she wasn't sure what date she conceived or the last date of her period they may have. http://www.babycenter.com/pregnancy-due-date-calculatorposted 07/16/2013 by ValleyOfSunMom
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May 5, 2016
Friday, May 4, 2012
NEW YORK (AP) -- Adam Yauch, the gravelly voiced Beastie Boys rapper who co-founded the seminal hip-hop group, has died at age 47.
Yauch's representatives confirmed that the rapper died Friday morning in New York after a nearly three-year battle with cancer.
Also known as MCA, Yauch was diagnosed with a cancerous salivary gland in 2009. He had undergone surgery and radiation.
At the time, Yauch expressed hope it was "very treatable," but his illness caused the group to cancel shows and delayed the release of its 2011 album, "Hot Sauce Committee, Pt. 2."
The Brooklyn-born Yauch created the Beastie Boys with high school friend Michael "Mike D" Diamond. Originally conceived as a hardcore punk group, it became a hip-hop trio after Adam "Ad-Rock" Horovitz joined.
(Copyright 2012, The Associated Press)
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Whether you're interested in starting to wear contact lenses, or want to know more about the latest research and developments in contact lens products, the BCLA website provides up-to-date independent guidance.
In this section, you will find everything you need to know about contact lens wear and care, including types of lenses, how to avoid infections, do's and don't's of contact lens wear, and contact lenses and sport.
Your contact lens practitioner can provide you with more information on what contact lenses can do for you, and the best lens type to suit your individual needs. Use our 'Find a contact lens practitioner' tool to locate your nearest BCLA member practitioner.
Please note: The BCLA can only provide general information that is not intended to be a substitute for a proper professional care and advice. If you have a specific question about your eyes or contact lenses, we recommend that you consult an eye care professional. While every effort has been made to ensure the accuracy of the information on this site, the BCLA will not accept liability for any loss or damage or inconvenience arising as a consequence of any information on this website.


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- Inhabitat – Green Design, Innovation, Architecture, Green Building - http://inhabitat.com -
Fisker Automotive Sets Two World Records for EV Charging in the Netherlands
Posted By Marc Carter On September 10, 2012 @ 2:00 pm In automotive,Electric Cars,Green Transportation,Innovation,News | No Comments
Fisker Automotive [1]'s Karma EV [2] just set two new world records at a recent event at the Floriade Horticultural World Expo [3] in Venlo, Netherlands. Fisker now holds the the world record for the highest number of single-brand electric vehicles to be charged simultaneously and the highest number of mixed-brand electric vehicles [4] to be charged simultaneously.
Fisker Nederland [5] -Fisker Automotive's most successful European representative, with more than 130 Karmas sold since January 2012 – organized the event on Sunday, September 2. Sixty 240-volt charge points were temporarily installed for the occasion. The "Floriade" expo focuses on innovation and the sustainable relationship between man and nature; this year's show focuses on how to return to nature and how to learn from it. The "Good Karma Day" pas part social gathering and part charity event for Dutch Fisker Karma owners — for every Karma sold by Fisker Nederland a donation was made to the Eugène Janssen Foundation [6] to support African children living in dire circumstances.
"We are excited that as an American car company we have had so many European Karma owners make this world-record attempt a success," said Koehler. "They have helped make history and show that electric vehicles [4] with extended range are the future."
Geert-Jan Tax said, "The success of Fisker [7] in the Dutch market underlines the massive potential that the Karma has around the globe. The Fisker Karma [8] is the first truly global vehicle that the American car industry has produced over the last few decades and certainly the most innovative. America should be proud of Fisker. The enthusiasm and engagement of our clients to bring 45 Karmas together on the last sunny weekend of the year is symbolic for the passion, product satisfaction and enthusiasm that is felt towards the Fisker [9] brand by all Karma owners and their families."
Fisker also recently held an an owner appreciation day [10] at its headquarters in Anaheim, CA where a 28 Fisker Karma [11] caravan drove down Pacific Coast Highway to Newport Beach.
Article printed from Inhabitat – Green Design, Innovation, Architecture, Green Building: http://inhabitat.com
URL to article: http://inhabitat.com/fisker-automotive-sets-two-world-records-for-ev-charging-in-the-netherlands/
URLs in this post:
[1] Fisker Automotive: http://www.fiskerautomotive.com
[2] Karma EV: http://onward.fiskerautomotive.com/en-us/karma/
[3] Floriade Horticultural World Expo: http://www.floriade.com/
[4] electric vehicles: http://inhabitat.com/index.php?s=electric+vehicles
[5] Fisker Nederland: http://www.fisker.nl/
[6] Eugène Janssen Foundation: http://www.eugenejanssenfoundation.nl/over-ons.html
[7] Fisker: http://inhabitat.com/video-inhabitat-interviews-henrik-fisker-founder-of-fisker-automotive-and-designer-of-the-karma/
[8] Fisker Karma: http://inhabitat.com/fisker-investigates-cause-of-second-karma-plug-in-hybrid-fire/
[9] Fisker: http://inhabitat.com/fisker-automotive-teams-up-with-leonardo-dicaprio-to-promote-global-sustainability/
[10] owner appreciation day: http://www.thetorquereport.com/2012/08/fisker_holds_the_largest_gathe.html
[11] Fisker Karma: http://inhabitat.com/fisker-karma-named-top-car-of-the-year-by-bbcs-top-gear/
Click here to print.
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text: A viscous fluid is flowing through two horizontal pipes. They have the same length, although the radius of one pipe is three times as large as the other. The pressure difference P2 ? P1 between the ends of each pipe is the same. If the volume flow rate in the narrower pipe is QA = 2.40 102 m3/s, what is the volume flow rate QB in the wider pipe?


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Tag Archives: exclusive breastfeeding
Booby Traps Series: Six breastfeeding myths you might hear at the doctor's office
This is the 56th post in a series on Booby Traps, made possible by the generous support of Motherlove Herbal Company. Why there so many breastfeeding myths, I don't know. But I do know that our health care providers, who … Continue reading
Last revised on 09/19/2012
Booby Traps Series: What part of "six months of exclusive breastfeeding" don't our providers understand?
This post is the 55th in a series on Booby Traps, made possible by the generous support of Motherlove Herbal Company. Have you heard any of these statements at your four or five month well child visit? "She looks great! … Continue reading
Last revised on 09/12/2012
Why a doula is your BFF (BreastFeeding Friend)
"If a doula were a drug, it would be unethical not to use it." – John H. Kennell, MD Doulas (trained support people for childbirth and postpartum) are associated with some great things: shorter labors, less interventions, fewer c-sections, and … Continue reading
Last revised on 06/30/2011
Messing with the Six Months Exclusive Breastfeeding Recommendation: Hidden Boobytrap
By now you may have read the latest sensationalist headline suggesting that six months of exclusive breastfeeding "could harm babies," according to the U.K.'s Guardian, which reported on a study in the British Medical Journal. The point of the study in the BMJ was to … Continue reading
Last revised on 01/17/2011


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May 6, 2016
Oklahoma State safety Daytawion Lowe has been named to the Jim Thorpe Award preseason watch list.
Lowe is one of 48 college defensive backs named to the watch list on Friday. The award is presented each year to the top college defensive back in the nation.
The winner of the award will be announced Dec. 12 and the Jim Thorpe Award banquet is scheduled for Feb. 4, 2014, in Oklahoma City.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)
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Named in honor of Louis Asbury, Sr., the Charlotte architect who designed the Mayfair Manor—now The Dunhill Hotel—in 1929, The Asbury celebrates the best of what the South has to offer in ingredients, technique, creativity, and, of course, hospitality. The Asbury is a tribute to Chef Coleman's southern roots and the culturally diverse community of the New South from which he draws inspiration.
At The Asbury, Chef Coleman creates menus and meals that are uniquely Carolinian: modern but rustic, evolving but still rooted in classics, southern and welcoming. There is a strong tie to heirloom ingredients native to our area, lost to time and modernization, as well as specialty items grown by small, family farms throughout the region. Chef Coleman searches out the best quality he can find—much of it coming from within the local region.
The Asbury serves lunch and dinner seven days a week, and brunch on Saturdays and Sundays. The Dunhill Hotel Bar features a selection of bar bites by Chef Coleman daily as well. In addition to the ground floor restaurant space, The Asbury caters unique, private dining experiences and hosts special events throughout its intimate second floor.


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Top Definition
(DULL-kənt) a person of limited intelligence who also happens to be a jerk; compound of "dull cunt"
I love that she kept mispronouncing words as she tried to insult us--what a dulcunt.
by porterkelly August 08, 2010
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This collection of images covers our family travels between 1960-1980 when we visited places such as Milan, Tehran, Kabul, Hong Kong and lived in England, Bangkok, Auckland, Melbourne and Maui. The cover image suggests some travel.
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From Above: Photos from the Window Seat. Published February 25, 2014
Candid Archive 1930 - 1980 Published January 19, 2014
The Cummings Archive: 1956 - 1966 Published January 19, 2014
It's all about the T Shirt Published January 30, 2010
Bloomfield Street Published August 02, 2009
Thailand Published August 04, 2006


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Other Transcription-Units in the Same Operon: bglG (bglGp2), bglG (bglGp)
The bglGFB operon codes for one of four β-glucoside utilization systems in E. coli [Moorthy02]. It codes for the autoregulatory antiterminator BglG, the EII glucoside transporter BglF, and the glucosidase BglB [Schnetz87]. This operon is silent in wild-type cells grown in the lab due to the transcriptional regulator HNS [Yasuzawa92], but it can be activated by insertion of an IS element upstream of the operon, as well as by point mutations within the CRP-binding site or within gyrA or gyrB [Schnetz92, Reynolds81, Reynolds86].
Once the operon is released from its silent state, it can be activated by Crp and repressed by Fis [Gulati00, Caramel00]. The bgl promoter is controlled by σS, whose effect is mediated by Crl [Moorthy02, Schnetz02]. Once silencing ceases, bglGFB expression is controlled by the aromatic β-glucosides salicin and arbutin via an mRNA antitermination mechanism [Schnetz88]. BglG is activated by phosphorylation by HPr (or FPr) but is inactivated by additional phosphorylation by BglF at a different site [Gorke99]. BglG is both phosphorylated and dephosphorylated by BglF, the enzyme II component of the Bgl sugar-transporting phosphotransferase system. The phosphorylation state of BglG at the BglF site is controlled by one of the β-glucoside inducers. In the absence of β-glucoside, BglG associates with and is phosphorylated by BglF in the cytoplasmic membrane. Addition of the inducer leads to dephosphorylation of BglG at the BglF site, and its localization to the cytoplasm where it forms homodimers and its transcriptional antitermination activity allows transcription of the bgl operon. The doubly phosphorylated form of BglG is unable to dimerize and bind to the target mRNA and does not have antiterminator activity [AmsterChoder92, Schnetz90, AmsterChoder90, AmsterChoder89, Lopian03, BenZeev05].
In the absence of the activated BglG homodimer, transcription from the bgl promoter is terminated at one of two rho-independent terminators. The first is located in the leader region of the bgl mRNA at a site immediately upstream of the bglG translation start site, and the second lies between bglG and bglF [Schnetz87, Mahadevan87, Schnetz88]. BglG is able to bind to a site in the bgl mRNA which partially overlaps the rho-independent terminators, possibly blocking the formation of the terminator secondary structure and allowing transcription [Houman90]. BlgG binding stabilizes the 5' end of the bgl mRNA [Gulati01]. BglG also binds the β-subunit of RNA polymerase [NussbaumShochat99].
In addition to these well-established forms of transcriptional regulation, the bgl operon expression is also affected by StpA, Hfq, LeO, and BglJ, but their specific mechanisms remain to be determined [Free98, Tsui94, Ueguchi98, Giel96].
Repression of the bglGFB operon by StpA occurs only in the presence of the N-terminal H-NS protein domain, which comprises the core for dimerization [Gueune08].
Citations: [Schaefler67, Schaefler67a]
Citations: [Reynolds86, Moorthy02, Schnetz02]
Absolute Position of Transcription Start Site: 3906697 base pairs
Position relative to start of first gene (bglG): -130
Site 1
H-NS (H-NS DNA-binding transcriptional dual regulator)
represses transcription.
Regulatory Summary: Hns is necessary but is not sufficient for repression of the bglB gene, and it was suggested that other cellular factors are involved in the repression of this gene.
Repression at this site requires the termination factor Rho and is reduced by translation of the bglG mRNA [Dole04].
Position of Site Center Relative to Transcription Start Site (bp): 680
Site Citations: [Dole04]
This site also regulates the following transcription units: bglG (bglGp)
Site 2
Fis (Fis DNA-binding transcriptional dual regulator)
represses transcription.
Position of Site Center Relative to Transcription Start Site (bp): -27
Site Summary: FIS-site II overlaps the -35 box.
Site Citations: [Caramel00]
This site also regulates the following transcription units: bglG (bglGp)
Site 3
Fis (Fis DNA-binding transcriptional dual regulator)
represses transcription.
Regulatory Summary: FIS-site I partially overlaps the CAP-binding site.
Position of Site Center Relative to Transcription Start Site (bp): -52
Site Citations: [Caramel00]
This site also regulates the following transcription units: bglG (bglGp)
Site 4
CRP-cAMP DNA-binding transcriptional dual regulator
activates transcription.
Position of Site Center Relative to Transcription Start Site (bp): -61.5
Site Citations: [Gulati00, Zheng04, Venkatesh10]
This site also regulates the following transcription units: bglG (bglGp), bglG (bglGp2)
Site 5
RcsBgl (RcsB-BglJ DNA-binding transcriptional activator)
activates transcription.
Regulatory Summary: BglJ induces bgl operon expression via unknown mechanisms [Giel96, Madhusudan05]. A modest effect was observed on expression of the bglGFB operon during the stationary phase by the BglJ transcriptional regulator in the absence of rpoS/crl [Madan08].
The response regulator RcsB can form heterodimers with RcsA [Kelm97] and GadE [CastanieCornet10] and it forms heterodimers with BglJ to activate the transcription of the bgl operon [Venkatesh10].
The RcsB-BglJ heteromer activates transcription of bglG synergistically with CRP, where it shifts the transcription start by 20 bp from a position typical for class I CRP-dependent promoters (bglGp) to a position typical for class II CRP-dependent promoters (bglGp2) [Salscheider14].
Activation of bglGp2 by RcsB-BglJ is CRP dependent, and the AR2 region of CRP is not involved in coactivation of this promoter by either regulator [Salscheider14]. BglJ-RcsB and CRP synergistically activate the bglGp2 promoter and relieve repression by HNS and StpA.
Position of Site Center Relative to Transcription Start Site (bp): -95.5
Site Citations: [Venkatesh10, Salscheider14]
This site also regulates the following transcription units: bglG (bglGp), bglG (bglGp2)
Site 6
LeuO (LeuO DNA-binding transcriptional dual regulator)
activates transcription.
Regulatory Summary: LeuO can fully antagonize the negative effect of H-NS on the bglGFB operon [Ueguchi98].
Position of Site Center Relative to Transcription Start Site (bp): -118
Site Citations: [Venkatesh10]
This site also regulates the following transcription units: bglG (bglGp)
Site 7
LeuO (LeuO DNA-binding transcriptional dual regulator)
activates transcription.
Regulatory Summary: LeuO can fully antagonize the negative effect of H-NS on the bglGFB operon [Ueguchi98].
Position of Site Center Relative to Transcription Start Site (bp): -149
Site Citations: [Venkatesh10]
This site also regulates the following transcription units: bglG (bglGp)
StpA (H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity)
represses transcription.
|Attenuation: BglG - his208 phosphorylated prevents premature termination of transcription
Attenuation Type: Protein-Mediated-Attenuation
Terminator Citations: [Schnetz87]
|Position Relative to Transcription Start
|Absolute Position
AmsterChoder89: Amster-Choder O, Houman F, Wright A (1989). "Protein phosphorylation regulates transcription of the beta-glucoside utilization operon in E. coli." Cell 1989;58(5);847-55. PMID: 2673534
AmsterChoder90: Amster-Choder O, Wright A (1990). "Regulation of activity of a transcriptional anti-terminator in E. coli by phosphorylation in vivo." Science 249(4968);540-2. PMID: 2200123
AmsterChoder92: Amster-Choder O, Wright A (1992). "Modulation of the dimerization of a transcriptional antiterminator protein by phosphorylation." Science 257(5075);1395-8. PMID: 1382312
BenZeev05: Ben-Zeev E, Fux L, Amster-Choder O, Eisenstein M (2005). "Experimental and computational characterization of the dimerization of the PTS-regulation domains of BglG from Escherichia coli." J Mol Biol 347(4);693-706. PMID: 15769463
Caramel00: Caramel A, Schnetz K (2000). "Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro." Mol Microbiol 36(1);85-92. PMID: 10760165
CastanieCornet10: Castanie-Cornet MP, Cam K, Bastiat B, Cros A, Bordes P, Gutierrez C (2010). "Acid stress response in Escherichia coli: mechanism of regulation of gadA transcription by RcsB and GadE." Nucleic Acids Res 38(11);3546-54. PMID: 20189963
Dole04: Dole S, Nagarajavel V, Schnetz K (2004). "The histone-like nucleoid structuring protein H-NS represses the Escherichia coli bgl operon downstream of the promoter." Mol Microbiol 52(2);589-600. PMID: 15066043
Free98: Free A, Williams RM, Dorman CJ (1998). "The StpA protein functions as a molecular adapter to mediate repression of the bgl operon by truncated H-NS in Escherichia coli." J Bacteriol 180(4);994-7. PMID: 9473058
Giel96: Giel M, Desnoyer M, Lopilato J (1996). "A mutation in a new gene, bglJ, activates the bgl operon in Escherichia coli K-12." Genetics 143(2);627-35. PMID: 8725214
Gorke99: Gorke B, Rak B (1999). "Catabolite control of Escherichia coli regulatory protein BglG activity by antagonistically acting phosphorylations." EMBO J 18(12);3370-9. PMID: 10369677
Gueune08: Gueune H, Durand MJ, Thouand G, DuBow MS (2008). "The ygaVP genes of Escherichia coli form a tributyltin-inducible operon." Appl Environ Microbiol 74(6);1954-8. PMID: 18245262
Gulati00: Gulati A, Mahadevan S (2000). "Mechanism of catabolite repression in the bgl operon of Escherichia coli: involvement of the anti-terminator BglG, CRP-cAMP and EIIAGlc in mediating glucose effect downstream of transcription initiation." Genes Cells 5(4);239-50. PMID: 10792463
Gulati01: Gulati A, Mahadevan S (2001). "The Escherichia coli antiterminator protein BglG stabilizes the 5'region of the bgl mRNA." J Biosci 26(2);193-203. PMID: 11426055
Houman90: Houman F, Diaz-Torres MR, Wright A (1990). "Transcriptional antitermination in the bgl operon of E. coli is modulated by a specific RNA binding protein." Cell 62(6);1153-63. PMID: 1698125
Kelm97: Kelm O, Kiecker C, Geider K, Bernhard F (1997). "Interaction of the regulator proteins RcsA and RcsB with the promoter of the operon for amylovoran biosynthesis in Erwinia amylovora." Mol Gen Genet 256(1);72-83. PMID: 9341681
Lopian03: Lopian L, Nussbaum-Shochat A, O'Day-Kerstein K, Wright A, Amster-Choder O (2003). "The BglF sensor recruits the BglG transcription regulator to the membrane and releases it on stimulation." Proc Natl Acad Sci U S A 100(12);7099-104. PMID: 12771379
Madan08: Madan R, Moorthy S, Mahadevan S (2008). "Enhanced expression of the bgl operon of Escherichia coli in the stationary phase." FEMS Microbiol Lett 288(1);131-9. PMID: 18793199
Madhusudan05: Madhusudan S, Paukner A, Klingen Y, Schnetz K (2005). "Independent regulation of H-NS-mediated silencing of the bgl operon at two levels: upstream by BglJ and LeuO and downstream by DnaKJ." Microbiology 151(Pt 10);3349-59. PMID: 16207917
Mahadevan87: Mahadevan S, Wright A (1987). "A bacterial gene involved in transcription antitermination: regulation at a rho-independent terminator in the bgl operon of E. coli." Cell 50(3);485-94. PMID: 3301003
Moorthy02: Moorthy S, Mahadevan S (2002). "Differential spectrum of mutations that activate the Escherichia coli bgl operon in an rpoS genetic background." J Bacteriol 184(14);4033-8. PMID: 12081976
NussbaumShochat99: Nussbaum-Shochat A, Amster-Choder O (1999). "BglG, the transcriptional antiterminator of the bgl system, interacts with the beta' subunit of the Escherichia coli RNA polymerase." Proc Natl Acad Sci U S A 96(8);4336-41. PMID: 10200263
Reynolds81: Reynolds AE, Felton J, Wright A (1981). "Insertion of DNA activates the cryptic bgl operon in E. coli K12." Nature 293(5834);625-9. PMID: 6270569
Reynolds86: Reynolds AE, Mahadevan S, LeGrice SF, Wright A (1986). "Enhancement of bacterial gene expression by insertion elements or by mutation in a CAP-cAMP binding site." J Mol Biol 191(1);85-95. PMID: 3025456
Salscheider14: Salscheider SL, Jahn A, Schnetz K (2014). "Transcriptional regulation by BglJ-RcsB, a pleiotropic heteromeric activator in Escherichia coli." Nucleic Acids Res 42(5);2999-3008. PMID: 24335284
Schaefler67: Schaefler S, Maas WK (1967). "Inducible system for the utilization of beta-glucosides in Escherichia coli. II. Description of mutant types and genetic analysis." J Bacteriol 93(1);264-72. PMID: 5335893
Schaefler67a: Schaefler S (1967). "Inducible system for the utilization of beta-glucosides in Escherichia coli. I. Active transport and utilization of beta-glucosides." J Bacteriol 93(1);254-63. PMID: 5335892
Schnetz02: Schnetz K (2002). "Silencing of the Escherichia coli bgl operon by RpoS requires Crl." Microbiology 148(Pt 8);2573-8. PMID: 12177351
Schnetz87: Schnetz K, Toloczyki C, Rak B (1987). "Beta-glucoside (bgl) operon of Escherichia coli K-12: nucleotide sequence, genetic organization, and possible evolutionary relationship to regulatory components of two Bacillus subtilis genes." J Bacteriol 169(6);2579-90. PMID: 3034860
Schnetz88: Schnetz K, Rak B (1988). "Regulation of the bgl operon of Escherichia coli by transcriptional antitermination." EMBO J 7(10);3271-7. PMID: 2846278
Schnetz90: Schnetz K, Rak B (1990). "Beta-glucoside permease represses the bgl operon of Escherichia coli by phosphorylation of the antiterminator protein and also interacts with glucose-specific enzyme III, the key element in catabolite control." Proc Natl Acad Sci U S A 87(13);5074-8. PMID: 2195546
Schnetz92: Schnetz K, Rak B (1992). "IS5: a mobile enhancer of transcription in Escherichia coli." Proc Natl Acad Sci U S A 1992;89(4);1244-8. PMID: 1311089
Schnetz96: Schnetz K, Wang JC (1996). "Silencing of the Escherichia coli bgl promoter: effects of template supercoiling and cell extracts on promoter activity in vitro." Nucleic Acids Res 24(12);2422-8. PMID: 8710516
Tsui94: Tsui HC, Leung HC, Winkler ME (1994). "Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12." Mol Microbiol 13(1);35-49. PMID: 7984093
Ueguchi98: Ueguchi C, Ohta T, Seto C, Suzuki T, Mizuno T (1998). "The leuO gene product has a latent ability to relieve bgl silencing in Escherichia coli." J Bacteriol 180(1);190-3. PMID: 9422614
Venkatesh10: Venkatesh GR, Kembou Koungni FC, Paukner A, Stratmann T, Blissenbach B, Schnetz K (2010). "BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS." J Bacteriol 192(24);6456-64. PMID: 20952573
Yasuzawa92: Yasuzawa K, Hayashi N, Goshima N, Kohno K, Imamoto F, Kano Y (1992). "Histone-like proteins are required for cell growth and constraint of supercoils in DNA." Gene 122(1);9-15. PMID: 1452042
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text:
|The images are in a file I have called "Romance" I have had it for years, but don't know where it came from - sorry. I have decoupaged the butterflies and tag and added 2 ribbons to complete it and join the A4 card together, hope you like it.
Thursday, 23 December 2010
21st Birthday
A friend of mine asked me to make her daughter a 21st birthday card, this is what I came up with
Posted by Daffodil Cards at 15:52
Labels: 21st
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