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Information for Religious Studies Job Applicants
Claremont McKenna College is a private liberal arts college located in Claremont, California, 35 miles east of downtown Los Angeles. The college has top-tier students and a serious commitment to scholarship.
Scholarly Community: One of the most attractive things about teaching Religious Studies at Claremont McKenna College is that it is part of an Intercollegiate Program.
The major in Religious Studies is a cooperative program offered jointly by Pomona, Claremont McKenna, Pitzer, Scripps and Harvey Mudd colleges. Most undergraduate professors in Religious Studies are elected to be faculty of Claremont Graduate University, whose graduate programs in Religion are internationally known, and whose students often populate undergraduate courses. All of these colleges are physically contiguous, so your colleagues at other colleges are at most a five-minute walk away. Effectively, then, each of us has dozens of colleagues in religious studies within the greater Claremont community, thus combining the faculty size of a large research university with the intimacy of a small liberal-arts college.
The Religious Studies program of study is designed to serve both as one focus of a liberal arts education and as a pre-professional foundation for students planning to pursue the study of religion beyond the baccalaureate degree. Students may enroll in Religious Studies courses offered at any of the undergraduate colleges, and advanced students may, with permission, enroll in master's-level courses in their area of specialization at Claremont Graduate University. While offering a broadly based and inclusive program in the study of religion for all liberal arts students, the Religious Studies major affords the opportunity for more specialized work at the intermediate and advanced levels in particular historic religious traditions, geographical areas, philosophical and critical approaches, and thematic and comparative studies.
The program in Religious Studies recognizes the importance and legitimacy of personal involvement in the study of religion, but it does not represent or advocate any particular religion as normative. Rather, our aim is to make possible an informed knowledge and awareness of the fundamental importance of the religious dimension in all human societies--Eastern and Western, ancient and modern. In addition to preparing students for graduate study in religion or the ministry, the multidisciplinary nature of the major affords students intellectual training to enter a variety of fields and careers. Recent graduates are, for example, in schools of law, medicine, and business administration. Others have careers in management, journalism and the media, college administration, primary and secondary education, government, and health and social services.
Religious Studies at Claremont McKenna College benefits from a rich interest in the discipline in the Claremont community, and students and faculty have access to a number of talks, lectures, and discussions at the Claremont colleges and surrounding areas.
Scholarship: Both the College and the Department of philosophy are committed to serious scholarship. You can get an idea of our research interests and publication records by looking at the faculty page. Our tenure standards are rigorous, but not so overwhelming that they prevent our faculty from having a serious focus on teaching.
Teaching: At Claremont McKenna, faculty are given the opportunity to seriously engage with their students. The teaching load is 2-2, courses are almost always capped at 19, and many classes are even smaller. Our students are among the best in the nation. 84% are in the top 10% of their graduating class, and their median SAT scores are 1400.
Location: The town of Claremont is close to downtown Los Angeles but far enough east that it doesn't suffer from the problems (e.g., traffic problems) of a large city. Claremont itself is a pleasant college town. The thing people like least is the smog and accompanying heat, which for about a month each summer reaches the 100's. (Though without humidity.) The town has plenty of benefits that compensate for the heat. You enjoy the ability to travel to Los Angeles for major cultural sites such as the many Los Angeles art museums, the philharmonic, and the Los Angeles Opera. The town is also good for people who love the outdoors, since we are situated at the base of a 10,000 foot mountain with wonderful hiking. The best thing about the location may be the almost-constant California sunshine.


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The Power of Independent Thinking
Love Gov on Stossel: "Let's Break Up with Government"
Recorded: Friday, September 25, 2015
Television personality John Stossel (host of Stossel on Fox Business) featured our new satirical, YouTube video seriesLove Gov: "From First Date to Mandate" on September 25th, 2015.
Experts: John StosselType: TelevisionIssues: Education, Government Power
John C. Goodman on Stossel
Recorded: Thursday, June 21, 2012
Research Fellow John C. Goodman, author of Priceless: Curing the Healthcare Crisis, joins a panel on Stossel to speak on today's healthcare issues.
Experts: John C. Goodman, John StosselType: TelevisionIssues: Free Market Economics, Health Care, Public Health/ Consumer Protection
John Stossel: Why Government FailsBut Free Individuals Succeed
Recorded: Thursday, April 19, 2012
Part 1 |
Part 2
John Stossel of Fox Business Network speaks about his new book, No, They Cant: Why Government FailsBut Individuals Succeed.
Experts: John StosselType: Independent Institute EventIssues: Culture/ Society, Free Market Economics, Freedom, Government Power, Government Waste/Pork
Living With a Nuclear Iran and North Korea?
Recorded: Thursday, June 21, 2007
Part 1 |
Part 2
Part 3
Part 4
Part 5
What if North Korea and Iran become nuclear states? If the United States must live with a nuclear Iran and North Korea, what policies should it adopt? Furthermore, could the U.S. change its foreign policy to reduce the risk of nuclear proliferation to even more countries?
Experts: Doug Bandow, Ivan Eland, Trita Parsi, Charles V. PeñaType: Independent Institute EventIssues: Defense and Foreign Policy
John Stossel | Confessions of a Media Maverick
Recorded: Friday, January 30, 2004
When pioneering television journalist John Stossel joined ABC-TV's "20/20" in 1981, his peers and an admiring public hailed him as a crusading consumer reporter. His hard-hitting, in-your-face exposes of con artists and corporate liars and crooks won him 19 Emmys and an avid following. But, could the use of government power and the Nanny State be the biggest scam of all?
In his new book, Give Me a Break, Stossel takes on a herd of sacred cows and examines how in the name of the "public interest," ambitious politicians and bureaucrats, intellectually lazy and opportunistic reporters, scaremongers, and predatory lawyers make life worse, especially for those most disadvantaged.
In this event John Stossel explained how his investigations of government waste, fraud and abuse; welfare for the rich; victimless crimes; self-serving interest groups; and sensationalist-media hyping (while ignoring real risks) reveal the crucial need to protect the civil and economic liberties of all people.
John Stossel, author of Give Me a Break. is co-anchor of ABC's "20/20." He also hosts ABC's "John Stossel Specials" for ABC television and radio, and ABCNews.com. In addition to having received 19 Emmy Awards, he has been honored five times for excellence in consumer reporting by the National Press Club. Among his other awards are the George Polk Award for Outstanding Local Reporting and the George Foster Peabody Award.
David J. Theroux is Founder and President of the Independent Institute.
Experts: John StosselType: Independent Institute EventIssues: Business, Culture/ Society, Entertainment, Free Market Economics, Government Power, Government Waste/Pork

subset: commoncrawl


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Confiscation - UK Supreme Court hearing today
I have treated myself to the luxury of viewing the live broadcast of the UK Supreme Court today. It has been Day 1 of a three day hearing of a confiscation case in relation to a mortgage fraud.
Unusually there are no less than 9 judges hearing this appeal. I speculate that this is because the appellant's contentions - if accepted - would overturn a great deal of legal precedent in relation to confiscation.
I have put my own summary of Day 1 online HERE if anyone is interested. I am only a spectator and doubtless my summary falls far short of doing justice to a full day of legal argument but I hope it gives a flavour of what went on.
Interesting indeed
It will be interesting to see how the Supreme Court resolves these issues. I look forward to their judgements
Summary of Day 2
Summary of Day 3
My own view
Having attempted to produce a reasonably fair summary of the arguments in the Supreme Court, I am taking the opportunity to express my own views.
Factually this was a reasonably simple case involving the benefit of only particular criminal conduct. D dishonestly obtained a mortgage advance which he used to purchase a flat. The flat went up in value. He legitimately obtained a new and larger mortgage, repaying the first mortgage in full. The flat continued to increase in value. D was convicted of mortgage fraud and subject to confiscation under PoCA 2002. The sole question before the court was the amount of his benefit.
Yet we have some of the best legal minds in the country coming up with a wide range of different figures for benefit. The only thing they seemed able to agree on was that the Crown Court judge had not been correct.
That means PoCA 2002 confiscation is neither simple nor straightforward. It lacks either clarity or certainty.
The explanatory notes to the Act said: "The purpose of confiscation proceedings is to recover the financial benefit that the offender has obtained from his criminal conduct. The court calculates the value of that benefit and orders the offender to pay an equivalent sum (or less where a lower sum is available for confiscation)".
PoCA does not do what it says on the tin.
Added to that parliament attempted to place Crown Court judges into a straitjacket to force them to do what government wanted in the name of being tough on crime.
The results have been manifestly unjust and the PoCA regime apparently inflexible.
What attracted me in the course of legal argument in Waya was the possibility that Crown Court judges might find release from the straightjacket by adopting an analysis based on the 'pecuniary advantage' obtained by the convicted defendant. That concept would take into account not simply the 'snapshot' or moment in time when the defendant 'obtained' property, but also the surrounding circumstances and events both before and after the 'snapshot' was taken.
In that way a judge could assess what the defendant's real financial benefit from his crime was and make a confiscation order related to that.
Is that too much to ask?
I would even suggest that adopting that approach in the Crown Courts requires no amendment to PoCA 2002 nor any authority in case law since the legislation is already to be found in s76(5). It has simply been the case up until now that prosecutors and judges have not read past s76(4). I wish they would do so.
It has to be admitted however that this approach would be of little assistance in those cases in which the defendant is held to have a 'criminal lifestyle' and a significant benefit arises from the operation of the statutory assumptions (which were not relevant to Waya). In those cases s10(6)(b), on paper at least, affords the Crown Court judge some discretion but in practice that provision has been interpreted narrowly. For example it has been suggested that there might be a serious risk of injustice if the defendant suffers from some mental infirmity or he had records which have been destroyed by fire - but not where the operation of the statutory assumptions simply produces a result which appears unfair.
Only a side issue, I know, but ...
... am I the only one to be curious as to how this fraud ever saw the light of day?
With kind regards
Clint Westwood
It may be that Mr Waya came to the attention of the police in the course of enquiries into another matter and that as a result investigations were made into his finances which brought the mortgage fraud to light.
Will there be a judgement from the Supreme Court?
Will the Supreme Court adjudicate on this matter? If so, I hope they apply some common sense and dismiss the esoteric arguments put forward by the prosecutors who seem to be stretching definitions somewhat.
My view is that that if the benefit is so difficult to quantify then it is non-existent. Waya obtained the mortgage fraudulently. He should be punished for this and this alone, via a gaol term / fine or both. He has repaid the amount he fraudulently obtained so why the confiscation proceedings? The victim of his crime, if ever there was one, has been compensated.
What about a job applicant who successfully persuades an interview panel to employ him/her and then 6 months later it turns out the applicant is incapable of living up to the expectations of the job? In retrospect, suppose the interview panel believes the applicant "bigged" themselves up at the interview to the point of fraudulent misrepresentation, despite there being no falsehoods on the application form. Would this be fraud? If so, how would the benefit of the crime be ascertained? The salary obtained? The employer's employment costs? The loans secured on the salary? In any case, it seems to me there can be a fine line between selling oneself and fraud.
I an curious as to whether Waya just "bigged up" his original mortgage application so as to get the advance. There seems to have been no intention of depriving the mortgagee and it seems as if the money obtained was used for the purpose for which it was granted. Every mortgage application is made for the purpose of obtaining a pecuniary advantage, usually the benefit of realising a holding gain on rising house prices. I am struggling to see the crime here, still more to see why confiscation proceedings are being pursued.
If everyone who "bigged up" their mortgage application were prosecuted there would be few mortgage advances! Let us hope that selling oneself at job interviews does not expose applicants to fraud and confiscation proceedings!
Judgment day (not yet) 2 thanks
The Supreme Court will hand down a judgment - probably in about June / July.
There have been cases where a job application form has been prepared dishonestly. For example a Mr Paulet falsely represented to potential employers that he was entitled to work in the UK, with the aid of a false identity document. In truth Mr Paulet was a visitor to the UK whose immigration status did not permit him to work here. His benefit for confiscation purposes was held to be the net pay he had received during his employment in the UK. There was no deduction for the value of the legitimate work he had performed for his employers. See CPS (Durham) v N [2009] EWCA Crim 1573 particularly paras [49] & [50].
Saying "I am a brilliant accountant" is probably not dishonest - even if one is "bigging" oneself up. Saying "I have an MBA from Harvard" is dishonest if, in fact, you do not hold that degree.
As for the offence in a case of mortgage fraud, note that an intention to "expose another to a risk of loss" is sufficient for the purposes of s2 Fraud Act 2006. I would say that anyone who obtains a mortgage exposes the lender to a risk of loss.
Time has flown.
Did they hand down a judgement yet?
Thanks for the summaries David
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Honors Program Information Night
Submitted on November 17, 2009 at 3:46 PM
Honors classes can challenge a student and help them find a new perspective on a subject. There is an emphasis on critical thinking, writing and discussion. The classes are tougher, but they are also smaller, and with increased interaction. Volunteer State Community College is holding an information session for current students, prospective students and parents to learn more about Honors courses. It will be Tuesday, December 1 at 7 p.m. in the Thigpen Library on the Vol State campus, 1480 Nashville Pike in Gallatin. Everyone is invited. For more information visit www.volstate.edu/honors or call 615-230-3281.
A service provided by the Office of Public Relations.


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Stoke wide-man Brek Shea scored the only goal of the match on a late breakaway as the USA beat Costa Rica to win their group and progress to the CONCACAF Gold Cup quarterfinals.
Manchester City will once again have to do without midfield maestro David Silva, possibly for the remainder of the season, due to a hamstring injury.
Tim Howard will officially get the sending off Everton fans were hoping for despite not being listed as the club's No. 1 goalkeeper.
Odion Ighalo looks likely to feature for Watford against Aston Villa this weekend despite the passing of his father last weekend.
Saido Berahino and Ben Foster face late fitness tests ahead of West Brom's match with West Ham at the Hawthorns.
Santi Cazorla has been ruled fit enough to participate against Norwich in Week 36 but his role isn't certain.
Stoke City left back Erik Pieters will be available again for the Potters in Week 36 after serving his two match suspension.
Xherdan Shaqiri is, once again, an uncertain prospect to start as he returns from a minor hamstring issue that kept him out of last weekend's 4-0 loss to Manchester City.
Marko Arnautovic faces a late fitness test ahead of Stoke City's Week 36 match with Sunderland at the Britannia.
Mauricio Pochettino has announced that he has made a verbal agreement with Tottenham to continue as manager for the next five seasons, extending his current deal an extra two years.
Jurgen Klopp made it known that Philippe Coutinho's early withdraw from Liverpool's loss to Villareal yesterday evening was due to an illness, putting his status for Sunday against Swansea City in doubt.
Eric Black confirmed Ciaran Clark is ready to return this weekend but Kieran Richardson will remain on the side-lines.


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AG017: Stairway to Devon
this wiki
After winning the Stone Badge from Roxanne, Ashand co. head out to the next gym, located on Dewford Island. However, Max spills a drink on May's PokéNav and rather than suffer her wrath, Max tries to find a quick solution. He sees an old man demonstrating new inventions but before he can go further, a younger man picks him up in a limo. Who is this old man, and can he help Max fix the PokéNav before May finds out it's broken?
Ash looks on his new badge, but asks Max where the next Gym is. Max looks on the device - it is Dewford Island. May and Brock read some brochures about Rustboro City. Despite Ash's will to go to the island, May and Brock decide it would be better to stay for a while in Rustboro City. Max is searching on PokéNav, but spills the drink over it, making the device useless.
Max travels around town, looking someone to repair the device. He spots a man advertising some products. One of them is a can opener, but when it opens the can, it sprays the liquid on him, so the audience disperses. The inventor turns on Max to come near him. Max explains his problem, to which the inventor replies that he should go to Devon - a company that makes a lot of inventions. A man steps out of car and running to the inventor, but the inventor goes away, so the man replies to others via his phone.
Ash contacts Prof. Oak, stating he won his first badge in Hoenn and that Pikachu knows Iron Tail attack. Brock and May have come from shopping, although May's a bit sick. It seems they are going to miss the boat to Dewford Island, but May's happy as she can do more shopping. Max came to Devon Corporation. Team Rocket arrives as well, hoping to steal some of the inventions. Max talks to the receptionist about repairing, but she tells him that they don't repair. Max walks away, but notices Officer Jenny talking - stating she heard rumors about someone infiltrating the Devon Corporation.
The inventor sneaks up on Max and guides him to a room. The inventor looks upon the PokéNav and spots that it has been wet from a drink. The inventor gives his scientists the PokéNav, demanding it to be repaired, to which the scientists agree, naming him as President. Max is surprised, as the guy following him (which is his helper) sometimes troubles him. The President guides Max for a tour of machines the company has been making - a Pokémon dream projector, Pokémon speaker and a Pokémon translator, although none have been finished. He stops for a while, showing Max the Pokémon producing machine. The machine analyzes a fossil and produces the Pokémon from the fossil.
Max asks if he should bring his friends inside, to which the President agrees. However, the man - the President's assistant - arrives to warn the President of the appointments he has to be in. Team Rocket thinks of how to bypass the security, so they disguise themselves as scientists. A man grabs some test tubes from Pokémon product. The President looks to the man that is leaving, so Max and him go to check upon him, as he knows that is not his employee.
Ash, May and Brock arrive to the Devon Corporation, asking the President's assistant where Max is. He shows them the way where Max would be. Team Rocket attempts to pass by, but Officer Jenny intercepts them, demanding their ID-s. The man whom Max and President followed goes away. The President guides Max's friends and tells Ash he reminds him of Steven, the President's son. They enter the testing area, but the scientists warn him that two tubes are missing.
Max and President follow the guy, but Max falls onto the stairs, warning the man. The man quickly climbs the stairs, running away. The President contacts his assistant, requiring assistance to track down the thief. Jessie and James try to get out of situation with Officer Jenny, saying that Meowth ate their cards. A speaker is saying that the thief is wearing glasses and a lab coat, making Team Rocket the suspects, so Jenny runs to them.
The man runs to the top, but is intercepted by May, Ash and Brock. The man calls his Crawdaunt. Pikachu uses Quick Attack to knock it out, afterwards the Crawdaunt attack Pikachu, damaging him. Team Rocket appears as well, with Jenny tracking them down. Crawdaunt uses Bubble Beam, attacking everyone. The man escapes, but Team Rocket grabs onto him, and Meowth searches into his pockets. Meowth finds the test tubes, but the rocket is failing (due to too much capacity). The tubes fall off, but Max catches all of them. Pikachu uses Thunderbolt, but it hits only Team Rocket.
The gang thinks who was the man, but Jenny implicates he might be a member of Team Aqua. The police found that he escaped - his lab coat and the rocket were thrown away. Later, the President praises Max, rewarding the gang with dinner. May asks for her PokéNav, making max nervous, but the President gives Max (secretly) the PokéNav. Max gives to May the PokéNav and thanks the President.
- "Come on, Ash, cool it. The Gym isn't going anywhere." - May
- Featured Pokémon: Slugma
- The name of the episode is a parody on the song Stairway to Heaven.


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Foul play is not suspected in the death of a person found in an alleyway on the southeast side of the Springs.
The body was found Friday morning in the alley that runs behind the All Work and No Play Barbershop and the Sherwin Williams paint shop on the 800 block of North Circle, near Galley.
The reporting party spotted the man "slumped over, head on his knees," according to police spokeswoman Barbara Miller, but did not want to approach him until police got there. Once authorities arrived it was determined he had died prior to officers arriving.
Police do not suspect foul play, but have sent his body to the coroner for an autopsy.
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Comments On Nov 23, 2012:Kept my hands warm in mid to low 40's weather.... Nice gloves but would not expect them to go sub zero by any means....
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Comments On Nov 19, 2012:Good for cool days, not cold days. Order at least 1-2 sizes larger than you think, they run small.
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Comments On Oct 31, 2012:I have used the Polar Paws for the last couple of winter seasons here in the Southwest. We don't often get rain, but is can get cold, especially in the mornings. I hate the frozen finger feeling, and these gloves are perfect for preventing it. Fit and durability are as good as most any other brand. If you don't have to deal with snow or wet weather, these will serve you well.
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Comments On Nov 12, 2011:First off these gloves are mis-named. They are good for riding in dry conditions with temps slightly colder than normal gloves would be used and thats about it. They are NOT good for cold, wet, off-road type riding.
I bought a pair of polarpaws way back in '99 that were all neoprene with fake leather palms. They were awesome for cold (down to low 40's), wet riding and after 10 years of regular use finally started falling apart, so I bought these. I guess its cheaper to add a teensy bit of insulation to their regular mx gloves than make a different one with different materials.
I also have a pair of new Pawtector gloves that wore a hole in one finger and started falling apart after just 2 hours of riding. I've been a HUGE Fox fanboy for many years but next time I'll try a different brand.
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August 6, 2010
Andrew Force
Get all of the information on UC's newest target. Reaching out to this Georgia star, UC takes a giant step towards landing a harpoon of a running back. Read about his comfort level with the spread offense and anticipated offers. ...More... To continue reading this article you must be a member. Sign Up Now!
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May 6, 2016
If you're looking for some Easter fun for the whole family, the Third Annual Spring Carnival is where you should be.
More than 2,500 people turned out Saturday afternoon at the Lynn Haven Community Center for the festival. The event featured a visit from the Easter Bunny, more than one bounce house, a hayride and much more.
All proceeds from the carnival will go to Bay Haven Charter academy's future Technology Center.
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RALEIGH - Gov. Pat McCrory has decided against spending up to $230,000 in taxpayer funds remodeling bathrooms in his private living quarters at North Carolina's Executive Mansion.
McCrory spokesman Kim Genardo issued this statement Saturday:
Raleigh, NC- The Office of Governor Pat McCrory released the following statement today:
"The governor has firmly communicated to the Department of Administration that not one penny of taxpayer dollars will be used to remodel or upgrade any of the six bathrooms in the living quarters of the State of North Carolina's executive mansion. Only a very limited amount of funds will be used to repair potential code violations, treat dangerous mold and fix broken faucets," said Kim Genardo, Governor's Communications Director.
The Associated Press reported Friday on plans to remodel six bathrooms in the Republican governor's private living area at the historic downtown Raleigh manor. A written estimate showed more than $100,000 of planned work to the master bathroom, including new marble, woodwork, bath fixtures and a ventilated water closet.


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Fort Wayne (Indiana's NewsCenter)- The St. Francis Cougars are coming off maybe the biggest win in the programs history with a 25-13 win over #1 St. Xavier.
The Cougars now have a bye week before taking on new #1 Marian. Kevin Donley, cornerback Allen Richardson and Tight End Clayton Smith joined us for this weeks show.
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Confiscation - second time around
I have written a new blog piece "Confiscation - second time around" on my own website which deals with the modifications to the ordinary PoCA 2002 confiscation provisions regarding the 'relevant day' and the statutory assumptions where a person is going through confiscation for a second time following a later conviction or convictions.
It is a situation which does not arise very often, but where it does there are some technical issues which have implications which you may find surprising.
The piece deals with the situation in which a defendant has been subject initially to a confiscation in which statutory assumptions regarding benefit applied (either under PoCA 2002 or an earlier confiscation regime) and is then subject to a fresh confiscation under the 'criminal lifestyle' assumptions of PoCA 2002 in England & Wales.
Because it is a technical piece dealing with a subject which does not affect most accountants I am not planning to reproduce it on AWEB - but if you want to read it follow this link.
Would you confirm, then, that ...
... the rehabilitation of offenders act, which under many circumstances requires that "spent" convictions over a particular age are regarded never to have happened at all, has no effect when considering the effect of very old confiscations in the application of current proceedings?
With kind regards
Clint Westwood
Rehabilitation of Offenders Act 1974
You have in mind s4(1) Rehabilitation of Offenders Act 1974 which provides:
(1) Subject to sections 7 and 8 below, a person who has become a rehabilitated person for the purposes of this Act in respect of a conviction shall be treated for all purposes in law as a person who has not committed or been charged with or prosecuted for or convicted of or sentenced for the offence or offences which were the subject of that conviction; and, notwithstanding the provisions of any other enactment or rule of law to the contrary, but subject as aforesaid —
(a) no evidence shall be admissible in any proceedings before a judicial authority exercising its jurisdiction or functions in Great Britain to prove that any such person has committed or been charged with or prosecuted for or convicted of or sentenced for any offence which was the subject of a spent conviction; and . . . .
However do not overlook section 7(2) of the same Act which includes
(2) Nothing in section 4(1) above shall affect the determination of any issue, or prevent the admission or requirement of any evidence, relating to a person's previous convictions or to circumstances ancillary thereto —
(a) in any criminal proceedings before a court in Great Britain (including any appeal or reference in a criminal matter) . . . .
In other words a 'spent' conviction is not 'spent' as soon as you cross the threshold of a criminal court.
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We went cruising at one of my most favorite places to find chiks...the beach. You can see a girls goods right there...a little try before you buy if you know what i mean. Anyways i found this hottie latina and asked if i could join her. She was totally down and we layed down and got some sun together. After a few beers and 100 degree sun i asked her if she wanted to come back and hang out at the pool at my house. It was an easy sell and we were back at the pad in no time. From there it was first the bikini top off and then the bottoms and then it just go crazy..
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#11 Mike Strong 2014 Brevard County Manatees Brevard Zoo Jersey
Description: You are bidding on a 2014 Brevard County Manatees Brevard Zoo Weekend Jersey that was worn by #11 Mike Strong. This jersey is a special Brevard Zoo inspired giraffe print jersey and this particular jersey is a size 48, the equivalent of an Extra Large. This jersey was worn the weekend of April 17-19, 2014 against the Dunedin Blue Jays. This auction will end on April 19, 2014 at 11:59 p.m. ET. Proceeds from this jersey auction will go to benefit the Brevard Zoo. For more information on the Brevard Zoo, visit brevardzoo.org. Following the auction, the Brevard County Manatees will contact you to find out what specific requests you have for the jersey that you have won (i.e. if you would like it autographed and if so, where on the jersey).
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text:
Utakata's Jinchūriki Forms
Revision as of 19:58, January 19, 2013 by AndreyNaruto (Talk | contribs)
this wiki
Utakata was the jinchūriki of Saiken — the Six-Tails. He's capable of using the Six-Tails' chakra in various and different levels, and was able to control the power up to the sixth tail. In the past, the Six-Tails has already manifested while protecting his vessel from any harm; but because of his power, he swore to never use it again.
Initial Jinchūriki Form
By using the Six-Tails' chakra, Utakata was capable of releasing its power and as such, turn the tide of battle in his favour. In contrast to Naruto, Utakata's eyes turn yellow while displaying this power, but he doesn't have any other changes like Naruto. With this, his physical power and chakra increase considerably making it possible for him to free himself from any control, such as Shiranami's Character Bind Technique. In this form, he displays the ability to manipulate his chakra into waves and blast, capable of overwhelming any opposition.
Version 1
By releasing more of the Six-Tails' chakra, Utakata can create a chakra cloak. With it, he can absorb and nullify powerful ninjutsu capable of easily destroying a village, as done with the Fury technique. The cloak was able to protect Utakata and Hotaru with no harm to her or to himself.
Version 2
Whilst reincarnated, Utakata displayed the ability to enter a "Version 2" form, by moulding the Six-Tails' chakra into a human-like shape around himself. When entering into this form, the sudden increase in chakra was such that it instantly vaporised Killer B's ink clone, which had immobilised him at the time.
In addition to forming a dark chakra cloak around his entire body, his appearance becomes more rounded, like that of the Six-Tails; while his hair still is noticeable covering his left eye, like his regular appearance. With the power granted by this form, Utakata not only manifests all of his beast's six tails, but also becomes able to ooze a highly corrosive, alkaline substance that seemingly makes it more difficult to trap or compress him.[1]
Partial Transformation
While it is unknown how much control Utakata had over the Six-Tails during his lifetime, after his reincarnation, he was able to form one of the beast's tails without the use of a chakra cloak.[2]
Full Six-Tails Form
While fighting Kakashi Hatake and Might Guy, Tobi forcefully transformed the revived Utakata into his full Six-Tails form. In this form, he takes on the appearance of the Six-Tails itself, allowing him to manipulate the full extent of the beast's considerable powers, including its ability to expel a gas that corrodes whatever it comes into direct contact with.[3] Like most other jinchūriki who have obtained their respective full tailed beast form, Utakata is also able to use the Tailed Beast Ball.[4]
In the anime, during the attempted forced extraction of the Six-Tails from Utakata's body by his master, Utakata slipped into his full Six-Tails form and killed Harusame. As a result of this incident, Utakata defected from Kirigakure and developed hatred towards master and student relationships, but it is not known if he was in control of his body during the transformation, or if the Six-Tails' own personality took over instead. However, when Utakata later tried to stop Hotaru's kinjutsu, he assumed this form while still retaining control, after asking the Six-Tails to give him the power to stop the technique.
See Also
- Gaara's Jinchūriki Forms
- Yugito Nii's Jinchūriki Forms
- Yagura's Jinchūriki Forms
- Rōshi's Jinchūriki Forms
- Han's Jinchūriki Forms
- Fū's Jinchūriki Forms
- Killer B's Jinchūriki Forms
- Naruto Uzumaki's Jinchūriki Forms
- Kinkaku's Jinchūriki Forms
- Sora's Jinchūriki Forms


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It's been a long time, but Kevin Bacon will once again take on the role of handyman Valentine McKee he originated in the 1990 monster movie Tremors. Bacon has signed on to star in and executive-produce a TV series reboot of the long-running movie franchise. It marks his first appearance in the series since the original movie, which was...
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Colorado Springs police said a teenager reported missing Saturday has been found.
Police initially asked for help locating Irasemma Inda, 13, indicating she may have been in danger.
They later determined she ran away and was found safe near her home.
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It's going to pack on solid muscle esp if your natural. Just be patience and stay the course!
It's going to pack on solid muscle esp if your natural. Just be patience and stay the course!
Diet is everything man. I use to be right at 160 too. I just ate everything I could and then ate some more. You can have the most intense workouts ever, but if you don't eat a ton it's all for nothing really. You'll shred up, but not gain mass. Eat tons of pasta and have 2 1,000+ calorie protein shakes daily. I use a banana, peanut butter, almonds, yogurt, dried oats and 1-2 scoops of good whey protein. After doing this I'm up to 190 give or take now.
Checkout the latest 2015 supplement reviews supplementyouneed.com
FYI, you are also overtraining. Too many sets with too high of an intensity of effort in my opinion. Try cutting all of your working sets in half and watch yourself blow up. Trust me on this.
Just wanted to say thanks to everyone for the advice. I've been eating like a machine and I'm up 5lbs in a month.
You said you think I'm over training.. Can you elaborate a little on what you would recommend? Thanks.
Any set that isn't a "warm up" set, reduce by 50%Try cutting all of your working sets in half
My training journal:
thecityalive is dead meat
Current RAW PRs:
Bench:255 (9/30/13)
Dead: 535 (1/12/15)
Squat: 455 (1/8/15)
Total: 1245 lbs.
None. I do 2 warm up sets.that I dont count as "sets"
Rob, that seems a little drastic doesn't it? I mean just my db press for example is only 90 lbs 4 sets of 8. Should I really cut down to like 45lbs? Thats what i do flies with.
The same was true when I was a bodybuilder.
As the other fellow said, cut your working sets in half and watch yourself get bigger and stronger.
Alright, since may just started I'll give it a shot for a month and see how it goes. 6 sets per muscle group 8 _10 rep range. . I'll start at it tomorrow.
No problem.. Thanks man
Give it about a month and let us know how you do.
I just gotta say that going from an hour + at the gym to 45 minutes is a big difference. I'm moving more weight and feel stronger already. I'll post the results soon.
Lol. It was a hard pill to swallow. I really didn't think I was over training but I'm glad you convinced me to cut it back. Proof is in the gains.
Can anyone tell me what I'm doing wrong to upload pictures? I was gonna put up a 30 day progress pic but it just doesn't let me.
Can anyone tell me what I'm doing wrong to upload pictures? I was gonna put up a 30 day progress pic but it just doesn't let me.
That's great news. Slow and steady will eventually get you where you want to be, keep it up man!


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Summary: Alkaline phosphatase
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Alkaline phosphatase Edit Wikipedia article
|Alkaline phosphatase
Ribbon diagram (rainbow-color, N-terminus = blue, C-terminus = red) of the dimeric structure of bacterial alkaline phosphatase.[1]
|EC number
|CAS number
|IntEnz view
|BRENDA entry
|NiceZyme view
|KEGG entry
|metabolic pathway
|PDB structures
|RCSB PDB PDBe PDBsum
|Gene Ontology
|AmiGO / EGO
|Alkaline phosphatase
Structure of alkaline phosphatase.[1]
Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) (EC 184.108.40.206) is a hydrolase enzyme responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. The process of removing the phosphate group is called dephosphorylation. As the name suggests, alkaline phosphatases are most effective in an alkaline environment. It is sometimes used synonymously as basic phosphatase.[2]
In Gram-negative bacteria, alkaline phosphatase is located in the periplasmic space, external to the cell membrane. Since this space is much more subject to environmental variation than the actual interior of the cell, bacterial alkaline phosphatase is comparatively resistant to inactivation, denaturation, and degradation, and also has a higher rate of activity. Although the purpose of the enzyme is not fully resolved, the simple hypothesis that it is a means for the bacteria to generate free phosphate groups for uptake and use is supported by the fact that alkaline phosphatase is usually produced by the bacteria only during phosphate starvation and not when phosphate is plentiful.[3] However, other possibilities exist. For instance, the presence of phosphate groups usually prevents organic molecules from passing through the membrane; therefore, dephosphorylating them may be important for bacterial uptake of organic compounds in the wild.[4] Some complexities of bacterial regulation and metabolism suggest that other, more subtle, purposes for the enzyme may also play a role for the cell. In the laboratory, however, mutant Escherichia coli lacking alkaline phosphatase survive quite well, as do mutants unable to shut off alkaline phosphatase production.[5]
The optimal pH for the activity of the E. coli enzyme is 8.0[6] while the bovine enzyme optimum pH is slightly higher at 8.5.[7]
Use in research
Typical uses in the lab for alkaline phosphatases include removing phosphate monoesters to prevent self-ligation, which is undesirable during plasmid DNA cloning.[8]
Common alkaline phosphatases used in research include:
- Shrimp alkaline phosphatase (SAP), from a species of Arctic shrimp (Pandalus borealis). This phosphatase is easily inactivated by heat, a useful feature in some applications.
- Calf-intestinal alkaline phosphatase (CIP)
- Placental alkaline phosphatase (PLAP) and its C terminally truncated version that lacks the last 24 amino acids (constituting the domain that targets for GPI membrane anchoring) - the secreted alkaline phosphatase (SEAP)
Alkaline phosphatase has become a useful tool in molecular biology laboratories, since DNA normally possesses phosphate groups on the 5' end. Removing these phosphates prevents the DNA from ligating (the 5' end attaching to the 3' end), thereby keeping DNA molecules linear until the next step of the process for which they are being prepared; also, removal of the phosphate groups allows radiolabeling (replacement by radioactive phosphate groups) in order to measure the presence of the labeled DNA through further steps in the process or experiment. For these purposes, the alkaline phosphatase from shrimp is the most useful, as it is the easiest to inactivate once it has done its job.
Another important use of alkaline phosphatase is as a label for enzyme immunoassays.
Undifferentiated pluripotent stem cells have elevated levels of alkaline phosphatase on their cell membrane, therefore alkaline phosphatase staining is used to detect these cells and to test pluripotency (i.e., embryonic stem cells or embryonal carcinoma cells).[9]
Dairy industry
Alkaline phosphatase is commonly used in the dairy industry as an indicator of successful pasteurization. This is because the most heat stable bacterium found in milk, Mycobacterium paratuberculosis, is destroyed by temperatures lower than those required to denature ALP. Therefore ALP presence is ideal for indicating successful pasteurization.[10][11]
Pasteurization verification is typically performed by measuring the fluorescence of a solution which becomes fluorescent when exposed to active ALP. Fluorimetry assays are required by milk producers in the UK to prove alkaline phosphatase has been denatured,[12] as p-Nitrophenylphosphate tests are not considered accurate enough to meet health standards.
Alternatively the colour change of a para-Nitrophenylphosphate substrate in a buffered solution (Aschaffenburg Mullen Test) can be used.[13] Raw milk would typically produce a yellow colouration within a couple of minutes, whereas properly pasteurised milk should show no change. There are exceptions to this, as in the case of heat-stable alkaline phophatases produced by some bacteria, but these bacteria should not be present in milk.
All mammalian alkaline phosphatase isoenzymes except placental (PALP and SEAP) are inhibited by homoarginine, and, in similar manner, all except the intestinal and placental ones are blocked by levamisole. Heating for ~2 hours at 65 °C inactivates most isoenzymes except placental isoforms (PALP and SEAP).[14] Phosphate is another inhibitor which competitively inhibits alkaline phosphatase.[15]
In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in the liver, bile duct, kidney, bone, intestinal mucosa and placenta. Humans and most other mammals contain the following alkaline phosphatase isozymes:
- ALPI – intestinal (molecular weight of 150 kDa)
- ALPL – tissue-nonspecific (liver/bone/kidney)
- ALPP – placental (Regan isozyme)
Diagnostic use
Normal ALP levels in adults are approximately 20 to 140 IU/L,[16] but levels are significantly higher in children and pregnant women. Blood tests should always be interpreted using the reference range from the laboratory that performed the test. High ALP levels can occur if the bile ducts are obstructed.[17] Also, ALP increases if there is active bone formation occurring, as ALP is a byproduct of osteoblast activity (such as the case in Paget's disease of bone). Levels are also elevated in people with untreated coeliac disease.[18] Lowered levels of ALP are less common than elevated levels. The source of elevated ALP levels can be deduced by obtaining serum levels of gamma glutamyltransferase (GGT). Concomitant increases of ALP with GGT should raise the suspicion of hepatobiliary disease.[19]
Elevated levels
If it is unclear why alkaline phosphatase is elevated, isoenzyme studies using electrophoresis can confirm the source of the ALP. Heat stability also distinguishes bone and liver isoenzymes[citation needed] ("bone burns, liver lasts"). Placental alkaline phosphatase is elevated in seminomas[20] and active forms of rickets, as well as in the following diseases and conditions:[21]
- Biliary obstruction
- Bone conditions
- Osteoblastic bone tumors
- Osteomalacia
- Liver disease or hepatitis
- Leukemia
- Lymphoma
- Paget's disease
- Sarcoidosis
- Hyperthyroidism
- Hyperparathyroidism
- Myocardial infarction
- Pregnancy
Lowered levels
The following conditions or diseases may lead to reduced levels of alkaline phosphatase:
- Hypophosphatasia, an autosomal recessive disease
- Postmenopausal women receiving estrogen therapy because of osteoporosis
- Men with recent heart surgery, malnutrition, magnesium deficiency, hypothyroidism, or severe anemia
- Children with achondroplasia and cretinism
- Children after a severe episode of enteritis
- Pernicious anemia
- Aplastic anemia
- Chronic myelogenous leukemia
- Wilson's disease
In addition, the following drugs have been demonstrated to reduce alkaline phosphatase:
- Oral contraceptives[22]
Leukocyte alkaline phosphatase
Leukocyte alkaline phosphatase (LAP) is found within mature white blood cells. White blood cell levels of LAP can help in the diagnosis of certain conditions.
- Higher levels are seen in polycythemia vera (PV), essential thrombocytosis (ET), primary myelofibrosis (PM), and the leukemoid reaction.
- Lower levels are found in chronic myelogenous leukemia[23] (CML), paroxysmal nocturnal hemoglobinuria (PNH) and acute myelogenous leukaemia (AML).
See also
- ^ a b PDB: 1ALK: Kim EE, Wyckoff HW (March 1991). "Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis". J. Mol. Biol. 218 (2): 449–64. doi:10.1016/0022-2836(91)90724-K. PMID 2010919.
- ^ Tamás L, Huttová J, Mistrk I, Kogan G (2002). "Effect of Carboxymethyl Chitin-Glucan on the Activity of Some Hydrolytic Enzymes in Maize Plants" (PDF). Chem. Pap. 56 (5): 326–329.
- ^ Horiuchi T, Horiuchi S, Mizuno D (May 1959). "A possible negative feedback phenomenon controlling formation of alkaline phosphomonoesterase in Escherichia coli". Nature 183 (4674): 1529–30. doi:10.1038/1831529b0. PMID 13666805.
- ^ Ammerman JW, Azam F (March 1985). "Bacterial 5-nucleotidase in aquatic ecosystems: a novel mechanism of phosphorus regeneration". Science 227 (4692): 1338–40. doi:10.1126/science.227.4692.1338. PMID 17793769.
- ^ Wanner BL, Latterell P (October 1980). "Mutants affected in alkaline phosphatase, expression: evidence for multiple positive regulators of the phosphate regulon in Escherichia coli". Genetics 96 (2): 353–66. PMC: 1214304. PMID 7021308.
- ^ Garen A, Levinthal C (March 1960). "A fine-structure genetic and chemical study of the enzyme alkaline phosphatase of E. coli. I. Purification and characterization of alkaline phosphatase". Biochim. Biophys. Acta 38: 470–83. doi:10.1016/0006-3002(60)91282-8. PMID 13826559.
- ^ Harada M, Udagawa N, Fukasawa K, Hiraoka BY, Mogi M (February 1986). "Inorganic pyrophosphatase activity of purified bovine pulp alkaline phosphatase at physiological pH". J. Dent. Res. 65 (2): 125–7. doi:10.1177/00220345860650020601. PMID 3003174.
- ^ Maxam AM, Gilbert W (1980). "Sequencing end-labeled DNA with base-specific chemical cleavages". Meth. Enzymol. Methods in Enzymology 65 (1): 499–560. doi:10.1016/S0076-6879(80)65059-9. ISBN 978-0-12-181965-1. PMID 6246368.
- ^ "Appendix E: Stem Cell Markers". Stem Cell Information. National Institutes of Health, U.S. Department of Health and Human Services. Retrieved 2013-09-24.
- ^ Kay, H. (1935). "Some Results of the Application of a Simple Test for Efficiency of Pasteurisation". The Lancet 225 (5835): 1516–1518. doi:10.1016/S0140-6736(01)12532-8.
- ^ Hoy, W. A.; Neave, F. K. (1937). "The Phosphatase Test for Efficient Pasteurisation". The Lancet 230 (5949): 595–598. doi:10.1016/S0140-6736(00)83378-4.
- ^ Aschaffenburg R, Mullen JEC (1949). "A rapid and simple phosphatase test for milk". Journal of Dairy Research 16 (1): 58–67. doi:10.1017/S0022029900005288.
- ^ Alkaline Phosphatase Why It Is Done from Everday Health.com. Retrieved October 15, 2012.
- ^ Iqbal, J (2011) "An enzyme immobilized microassay in capillary electrophoresis for characterization and inhibition studies of alkaline phosphatases" J Anal. Biochem. 414, 226-231
- ^ "MedlinePlus Medical Encyclopedia: ALP isoenzyme test".
- ^ ALP: The Test
- ^ Preussner, Harold T, HT (March 1998). "Detecting coeliac disease in your patients". American Family Physician 57 (5): 1023–1034. PMID 9518950.
- ^ Vroon, David. "Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition".
- ^ Lange PH, Millan JL, Stigbrand T, Vessella RL, Ruoslahti E, Fishman WH (August 1982). "Placental alkaline phosphatase as a tumor marker for seminoma". Cancer Res. 42 (8): 3244–7. PMID 7093962.
- ^ Dugdale, David C. "ALP-bloodtest:MedlinePlus Medical Encyclopedia". MedlinePlus. Retrieved 2014-02-26.
- ^ Schiele F, Vincent-Viry M, Fournier B, Starck M, Siest G (November 1998). "Biological effects of eleven combined oral contraceptives on serum triglycerides, gamma-glutamyltransferase, alkaline phosphatase, bilirubin and other biochemical variables". Clin. Chem. Lab. Med. 36 (11): 871–8. doi:10.1515/CCLM.1998.153. PMID 9877094.
- ^ Arceci RJ, Hann IM, Smith OP, ed. (2006). Pediatric hematology (3rd ed.). Wiley-Blackwell. p. 763. ISBN 978-1-4051-3400-2.
External links
- Alkaline phosphatase at Lab Tests Online
Further reading
- Coleman JE (1992). "Structure and mechanism of alkaline phosphatase". Annu Rev Biophys Biomol Struct 21: 441–83. doi:10.1146/annurev.bb.21.060192.002301. PMID 1525473.
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Alkaline phosphatase Provide feedback
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Internal database links
|Sulfatase Phosphodiest Metalloenzyme PglZ
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR001952
This entry represents alkaline phosphatases (EC) (ALP), which act as non-specific phosphomonoesterases to hydrolyse phosphate esters, optimally at high pH. The reaction mechanism involves the attack of a serine alkoxide on a phosphorus of the substrate to form a transient covalent enzyme-phosphate complex, followed by the hydrolysis of the serine phosphate. Alkaline phosphatases are found in all kingdoms of life, with the exception of some plants. Alkaline phosphatases are metalloenzymes that exist as a dimer, each monomer binding metal ions. The metal ions they carry can differ, although zinc and magnesium are the most common. For example, Escherichia coli alkaline phosphatase (encoded by phoA) requires the presence of two zinc ions bound at the M1 and M2 metal sites, and one magnesium ion bound at the M3 site [PUBMED:15938627]. However, alkaline phosphatases from Thermotoga maritima and Bacillus subtilis require cobalt for maximal activity [PUBMED:11910033].
In mammals, there are four alkaline phosphatase isozymes: placental, placental-like (germ cell), intestinal and tissue-nonspecific (liver/bone/kidney). All four isozymes are anchored to the outer surface of the plasma membrane by a covalently attached glycosylphosphatidylinositol (GPI) anchor [PUBMED:17520090]. Human alkaline phosphatases have four metal binding sites: two for zinc, one for magnesium, and one for calcium ion. Placental alkaline phosphatase (ALPP or PLAP) is highly polymorphic, with at least three common alleles [PUBMED:11124260]. Its activity is down-regulated by a number of effectors such as l-phenylalanine, 5'-AMP, and by p-nitrophenyl-phosphonate (PNPPate) [PUBMED:15946677]. The placental-like isozyme (ALPPL or PLAP-like) is elevated in germ cell tumours. The intestinal isozyme (ALPI or IAP) has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier [PUBMED:18292227]. The tissue-nonspecific isozyme (ALPL) is, and may play a role in skeletal mineralisation. Defects in ALPL are a cause of hypophosphatasia, including infantile-type (OMIM:241500), childhood-type (OMIM:241510) and adult-type (OMIM:146300). Hhypophosphatasia is an inherited metabolic bone disease characterised by defective skeletal mineralisation [PUBMED:17719863].
This entry also contains the related enzyme streptomycin-6-phosphate phosphatase (EC) (encoded by strK) from Streptomyces species. This enzyme is involved in the synthesis of the antibiotic streptomycin, specifically cleaving both streptomycin-6-phosphate and, more slowly, streptomycin-3-phosphate [PUBMED:1654502].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function
|phosphatase activity (GO:0016791)
|Biological process
|metabolic process (GO:0008152)
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- a link to the page in the Pfam site showing information about the sequence that the graphic describes
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Note that you can see the family page for a particular domain by clicking on the graphic. You can also choose to see all sequences which have a given architecture by clicking on the Show link in each row.
Finally, because some families can be found in a very large number of architectures, we load only the first fifty architectures by default. If you want to see more architectures, click the button at the bottom of the page to load the next set.
Loading domain graphics...
Pfam Clan
This family is a member of clan Alk_phosphatase (CL0088), which has the following description:
The members of this clan all share a common structure of their catalytic domains, which contain conserved metal binding residues [1].
The clan contains the following 10 members:Alk_phosphatase DUF1501 DUF229 DUF4976 Metalloenzyme PglZ Phosphodiest Phosphoesterase Sulfatase Sulfatase_C
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
There are various ways to view or download the sequence alignments that we store. We provide several sequence viewers and a plain-text Stockholm-format file for download.
Alignment types
We make a range of alignments for each Pfam-A family:
- seed
- the curated alignment from which the HMM for the family is built
- full
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- UniProt
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- meta
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
- jalview
- a Java applet developed at the University of Dundee. You will need Java installed before running jalview
- an HTML page showing the whole alignment.Please note: full Pfam alignments can be very large. These HTML views are extremely large and often cause problems for browsers. Please use either jalview or the Pfam viewer if you have trouble viewing the HTML version
- PP/Heatmap
- an HTML-based representation of the alignment, coloured according to the posterior-probability (PP) values from the HMM. As for the standard HTML view, heatmap alignments can also be very large and slow to render.
You can download (or view in your browser) a text representation of a Pfam alignment in various formats:
- Selex
- Stockholm
You can also change the order in which sequences are listed in the alignment, change how insertions are represented, alter the characters that are used to represent gaps in sequences and, finally, choose whether to download the alignment or to view it in your browser directly.
You may find that large alignments cause problems for the viewers and the reformatting tool, so we also provide all alignments in Stockholm format. You can download either the plain text alignment, or a gzipped version of it.
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
Format an alignment
Download options
We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Previous IDs:
|Finn RD
|Number in seed:
|Number in full:
|Average length of the domain:
|368.80 aa
|Average identity of full alignment:
|27 %
|Average coverage of the sequence by the domain:
|78.22 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
Tree controlsHide
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- graphically
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The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Alk_phosphatase domain has been found. There are 216 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
Loading structure mapping...


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January 21st, 2013
5@5 is a daily, food-related list from chefs, writers, political pundits, musicians, actors, and all manner of opinionated people from around the globe.
"Don't mess with a good thing."
"There's no need to reinvent the wheel."
"If it ain't broke, don't fix it."
However many adages there are that extol the virtues of the classics, there is always room for minor tweaking - especially when it comes to matters of taste, like cocktails.
According to Adam Bernbach, the bar manager of Proof and Estadio restaurants in Washington, D.C., there are a couple of things experimental imbibers should pay attention to when riffing on the classics.
Five Tips on Getting Creative with Classic Cocktails: Adam Bernbach
1. Taste
This can, of course, be prohibitively expensive in practice. However, keeping on the lookout for tastings held by restaurants, bars and the like will help accelerate the "studies."
2. Read
Classics like Harry Craddock's "The Savoy Cocktail Book, " David Embury's "The Fine Art of Mixing Drinks," and newer classics like Kazuo Uyeda's "Cocktail Techniques," Jim Meehan's "The PDT Cocktail Book" and David Wondrich's great Jerry Thomas biographical recipe book "Imbibe" are major sources of exposure to different techniques and ideas, new and old, in mixing drinks. Many of these books contain recipes for various syrups that will be irreplaceable in reproducing the classic cocktails.
3. Visit a bartender
Polite, well-timed questions are welcome. Bartenders who are genuinely interested in the craft and history of mixing drinks are more than happy to share their opinions, their experiences and what they've learned. Naturally, there is a time and place for these Q&As. A busy Saturday night is not the ideal time to elicit pearls of wisdom from a bartender. Earlier in the night and the week tend to be the best times to chat.
4. Build your home bar
Building up a nice collection of spirits can sometimes be a tricky endeavor. Some of the ingredients common in the classics are not common now. That doesn't necessarily mean they're unavailable. Usually, it's a small percentage of stores that carry these ingredients. It might require some calling around. If a local store doesn't carry them (and they can't special order them), sites like Astor Wines have a nice selection in which to find a missing ingredient. Procuring the ingredients to a cocktail, one cocktail at a time is an efficient way to build the home bar.
5. Adjust and swap
Another great variation is to replace one ingredient with another. A seemingly small switch from sugar to honey will create a different drink entirely. In one Manhattan, rather than simply using angostura bitters, I chose to accentuate the lighter, floral qualities of red vermouth (I use Dolin Rouge) mixed with rye whiskey (I use Old Overholt) by utilizing the anise, fennel, herbal notes in Peychaud's bitters. This creates a bright, lively version of the rich classic we know.
2.25 oz. rye whiskey (Recommended: Old Overholt)
Stir. Strain into a cocktail glass. Garnish with a brandied cherry. (Rub a bit of lemon zest on the rim of the glass.)
Above, Adam Bernbach shared his riff on a classic Manhattan. Have you shaken up a classic cocktail recipe? Share your liquid pleasure in the comment section below.
Previously - A toast to Hollywood's classic cocktails and Master the Sazerac cocktail
Is there someone you'd like to see in the hot seat? Let us know in the comments below and if we agree, we'll do our best to chase 'em down.
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United Kingdom
this wiki
|United Kingdom of Great Britain and Northern Ireland
|Anthem: "God Save the Queen"
(and largest city)
|Official language(s)
|Unitary parliamentary constitutional monarchy
|1 May 1707
The United Kingdom of Great Britain and Northern Ireland (commonly known as the United Kingdom, the UK or Britain) is a sovereign state located off the north-western coast of continental Europe. Its capital city is London. It consists of four constituent countries: England, Scotland, Wales and Northern Ireland. Apart from its land border with the Republic of Ireland, the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel and the Irish Sea.
The UK is the setting for Grand Theft Auto: London 1969 and Grand Theft Auto: London 1961. The city of London is the centerpiece of those two video games.
The Grand Theft Auto games are developed in the United Kingdom, more specifically in Scotland, where Rockstar North is based. The games are first shipped to the United States of America and Canada, before they are made available in the UK and the remainder of continental Europe, Australia, New Zealand, and the rest of the world.
The UK is currently home to four Rockstar studios:
The United Kingdom is also home to the BBFC rating system, which has been the harshest on the Grand Theft Auto series. Dan Houser, Sam Houser, Terry Donovan and Gary Dale are all British.
- Freddy is first heard on Chatterbox FM where he speaks to Lazlow about nannies (and he wanted to be spanked). He is also voiced by Dan Houser.
- The Ammu-Nation owner is voiced by Sam Houser.
GTA: Liberty City Stories
- The V8 Ghost is a British exotic car based on the Lotus Esprit.
- The Pilgrim's Pantry advert announcer's voice sounds British.
GTA: Vice City
- Kent Paul comes from England and he moves to San Andreas in 1992.
- Love Fist are a Scottish rock band.
- The Ammu-Nation owner is voiced by Sam Houser.
- As said in the official GTA Vice City Website, the Washington is imported from the UK.
GTA: Vice City Stories
- Phil Collins stars himself in this game, his assistant is Barry Mickelthwaite who is British as well.
- There is a space programme on any radio station which features voices that sound British.
- The announcer of the Buy American Coalition (the national organisation that keeps the United States of America independent from foreign goods) slightly slams the Brits by telling them to "shove cups of tea up their limey asses, and show them the American spirit - by drinking boomshine and killing natives instead."
- The Splitz-6 ATV is based on the Supacat, which is a British vehicle manufactured by that company.
- Trish Camden, co-host of Wave 103, is British. She thinks of her co-hosting an American radio station a little bit of a "British invasion" and says she wants to bring a little bit of Britain onto the American radio. By 1986 she appears to have left the station, maybe to become a VJ which she mentions wanting to do.
GTA: San Andreas
- Maccer is a British character from Salford, while Shaun Ryder (who voiced him) also lives in Salford.
- The Carcer City and Hampshire Nannies adverts are hosted by British advertisers.
- The Stafford (Rolls-Royce Silver Shadow) and Windsor (Jaguar XKE) are British cars.
- Some of the pedestrians are British, which can be heard using expletives such as "wanker" and "bollocks", as well as being disrespectful towards Americans. There are other pedestrians who have claimed to have slept with a Scotsman.
- In some safehouses, there are guidebooks for different places, including Edinburgh, Scotland.
- There are car license plates with the names 'Glasgow' and 'Rangers', the biggest city in Scotland and a football club from that city.
- Gay Tony mentions that he has clubs in London.
- Daisie Cash-Cooze is a Londoner who moved to Liberty City.
- Ricky Gervais and Frankie Boyle are British comedians that make shows at the Split Sides comedy club.
- In Middle Park, Algonquin there is a British Embassy with two Union Jacks that is near the Algonquin
- Safehouse and Grotti.
- The buskers are played by Walter Houser, who is the father of the British Rockstar Games executive producers Sam Houser and Dan Houser.
- DJ Paul, the DJ of Vladivostok FM is from the United Kingdom.
- Dewbauchee, Enus and Ocelot are three British car manufacturers that make their debut appearance in this game.


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Everyone loves Disney right? OF COURSE I AM RIGHT. So heres a thread (Im not calling the title "the Disney thread" cos that's just stupid am I right!)
So anyway my fave Disney movies are Lion King Aladdin and Sleeping Beauty all epic journeys with epic villians and memorable protagonists (the 3 fairy's are the protagonist in Sleeping Beauty not the price or princess and they are memroble). I also love Fantasia and there TV cartoons I also love Disney merchendice just wish it wasnt expensive as holy hell.
So what's your fave disney movies and what do you love and hate about it?


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What is RM Cash
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Here's the second step: blocking in the main areas. Floors, walls, and major stuff is there. Now to cut some doors and get it looking right. BTW, the towers will be somewhat higher than the walls and the walls will have crenelations on the outer edges and a small lip on the inner. The textures are just placeholders for now.
Not sure what I'm going to do about lighting but the world has no (lit) sun, just a couple of moons so I'll probably do the moonlit blue cast thing that I did for the Wastelands Encounter battlemap I did for this client, with some actual lighting in the keep.
Now I'm off to get back to "real" work for a while. C&C appreciated.


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DENVER (AP) -- Denver Broncos linebacker D.J. Williams will serve 30 days under home arrest for driving under the influence but not until after the season.
Williams was sentenced Wednesday in Denver but a judge said he didn't have to start serving it until Feb. 7, 2013.
Prosecutors had asked that Williams serve 30 days in jail.
Besides the home arrest, Williams will have to be on probation for two years, have his sobriety monitored and attend alcohol education classes and therapy. He also must perform 56 hours of community service and pay $2,390 in court costs.
Williams is serving a nine-game suspension, partly because of his August conviction for driving while ability impaired.
The team's leading tackler in four of the last five seasons won't return to the Broncos until Nov. 12.
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The Power of Independent Thinking
Ron Paul: Whistleblowers are Heroes
Recorded: Wednesday, April 9, 2014
In this clip from "Ron Paul: Liberty Defined," Dr. Paul calls out the U.S. government for rewarding criminals and punishing whistleblowers.
Experts: Ron PaulType: Independent Institute EventIssues: Civil Liberties/ Human Rights, Constitutional Law, Defense and Foreign Policy, Freedom, Government Power, Political Ideology and Philosophy
Ron Paul: All You Have To Do Is Scare Them
Recorded: Wednesday, April 9, 2014
April 9, 2014
In this clip from "Ron Paul: Liberty Defined," Dr. Paul talks about how governments instill fear in populations through propaganda.
Experts: Ron PaulType: Independent Institute EventIssues: Bureaucracy and Government, Civil Liberties/ Human Rights, Constitutional Law, Democracy, Freedom, Government Power, Government Secrecy, Politics, Terrorism and National Crises
A Gala for Liberty: Special Tribute from Ron Paul
Recorded: Tuesday, November 15, 2011
The Independent Institutes 25th Anniversary with Congressman Ron Paul and Independent Institute President David J. Theroux.
Experts: Ron Paul, David J. TherouxType: Independent Institute EventIssues: Freedom, History (U.S), Political Ideology and Philosophy
Bush, Obama, and Presidential Power
Recorded: Wednesday, January 7, 2009
Part 1 |
Part 2
Part 3
Was George W. Bush the worst president ever? Ivan Eland examines Bushs presidency and those of his predecessors to determine if their policies promoted peace, prosperity, and liberty while upholding the Constitution they swore to protect.
Experts: Ivan Eland, Ron Paul, Richard ShenkmanType: Independent Institute EventIssues: Banking and Finance, Bureaucracy and Government, Civil Liberties/ Human Rights, Constitutional Law, Culture/ Society, Defense and Foreign Policy, Democracy, Economic History and Development (U.S.), Economic Policy, Freedom, Government Power, History (U.S), Nationalism, Political Ideology and Philosophy, Politics, Privacy, Terrorism and National Crises