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Her voice was clean and cool, full of melismatic embellishments. It spoke of dazzling virtuosity rather than raw power or emotions dredged from the depths of a troubled soul. Even when her public image spiralled out of control, her music didn't follow suit.
she didn't take risks with her emotions while singing, though the pyrotechnics were a reasonable facsimile.
larger-than-life voice, a wonder of nature (and the creme de la creme musical nurture).
while it seems you never found what you were looking for, RIP, whitney, you sure touched many people with your gifts and range, epic in your one-off way.
'The history of public debt is full of irony. It rarely follows our ideas of order and justice.' Thomas Piketty
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We expose slave masters and people smugglers in suburban Britain.
Is there more to life than money?
Racism against Roma people is rampant in Czech educational institutions.
08 May 2015 08:32 GMT | Human Rights, Europe, Czech Republic
Amnesty International discloses details of a series of Israeli attacks carried out in Gaza on Palest
07 Nov 2014 12:48 GMT | Humanitarian crises, War & Conflict, Politics, Israel, Palestine
Amnesty International has uncovered evidence of brutal extrajudicial killings and massacres in Niger
05 Aug 2014 11:04 GMT | War & Conflict, Politics, Humanitarian crises, Niger, Nigeria
World Economic Forum on Africa opens in Nigeria under long shadow cast by the plight of abducted schoolgirls.
Salil Shetty | 07 May 2014 11:37 GMT | Politics, Niger, Nigeria, South Africa
Institutional mechanisms for intervention after the Rwandan genocide did not prevent violence in CAR and South Sudan.
Salil Shetty | 17 Apr 2014 14:15 GMT | Politics, Central African Republic, Chad, Rwanda
A new UN protocol raises economic and cultural rights to the same prominence as civil and political rights.
Salil Shetty | 06 May 2013 14:27 GMT | Politics, Latin America, Argentina, Ecuador, Mongolia
International law should be enforcing governments to create frameworks that foster citizens to realise their rights.
Salil Shetty | 25 Jan 2013 12:01 GMT | China, Greece, United Kingdom
If "official lawlessness is denied and goes unpunished", Nigeria will not gain the stability it so badly needs.
Salil Shetty | 11 Jan 2013 06:10 GMT | Niger, Nigeria
The criminal court is a great achievement in international justice, but it must do better in its next decade.
Salil Shetty | 01 Jul 2012 16:23 GMT | Politics, Latin America, Afghanistan, Botswana, Central African Republic
We examine how cyber thieves are hacking the world's financial architecture and why it's not just about money.
Business & Economy, Science & Technology, Crime
We follow the journey of Kenyans seeking justice for Britain's role in the torture during the 1950s Mau Mau uprising.
Kenya, United Kingdom, Africa
People & Power investigates the environmental consequences of palm oil plantations in equatorial Africa.
Environment, Africa, Cameroon
Five years on, Misratans reflect on the siege of their city and how it played a role in the downfall of Gaddafi.
Libya, War & Conflict, Muammar Gaddafi

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Prior to 1948, what was the name of the territory that is now called "Israel"?
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The only reason the state of Israel exists at all is because the western powers of the mid-19th Century willed it to be so. Jews, being almost Christians, were the perfect candidates for the creation of a buffer zone between the British and French holdings in North Africa.
Using their stories about some God-given birthright, Jews began emigrating from Europe to their "holy land" in the 1840s. This pleased the Western European PTB of the day as they would soon have a buffer against any Russian advances south into North Africa and the Med Coast.
The dream finally became a reality in 1948 with the creation of the state of Israel, and while the Israelis were forced to fight for their very existence a couple of times against the massed armies of their rambunctious Arab neighbours, the existence of Israel in such a strategic area served to limit Soviet expansion and air and naval movements during the Cold War of the 1950s to 1990s.
Israel was very convenient for Western civilisation and will remain so for the foreseeable future. When it ceases to be convenient they'll throw it to the wolves.
Link: [
link to trove.nla.gov.au
] 1841 newspaper article entitled - "Restoration of the Jews To Palestine". Whoa! He called it "Palestine"? In 1841? Must have been an early form of typo.
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Truth behind chemo: 'These drugs were derived from WWI chemicals'
Wisconsin city passes ordinance to fine parents of bullies hundreds of dollars
Donald Trump is now the Republican nominee Trump to stand unopposed as John Kasich ends Republican nomination bid
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New study prompts caution for all those taking diabetes medication: some drug brands may increase the spread of cancer
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Whenever I receive a FaceTime call it does not ring I have checked in settings to make sure the noises and alert ect. Are all turned on.u
There have been many, many users reporting problems with FaceTime since April 16th. This was Apple's response to the problems.
It doesn't deal with sound issues however. Can you still make and receive FaceTime calls with no other issues? Are you getting all other notification sounds?
This used to show up as a question with some frequency - but i havent seen it in the last year. used to be a pad 2 issue, and I see you have a pad 2. While i had the pad 2, that would be a problem from time to time - but went away, and I was never clear on the cause.
So - the basics. You have already checked in notifications, and the alert spound is on. Ringer and alerts volume slider is not all the way down? (this is the only app that uses the ringer - as far as I know)
System sounds are on? (pad is not muted)
I would suggest you continue to play around with the settings. (You can facetime yourself from your iphone -if you are so equipped - so quick tests are easy)
Thank you I found out that it was muted thank you
I have fixed the issue know thank you this helped
You're quite welcome. I'm happy to hear that you found the cause of the problem and got it all sorted out.
I had an issue with my IPAD not ringing with an incoming Facetime call. My issue was solved by going to Settings > Sounds. I turned up the volume on Ringer and alerts. that did the trick!
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Join NAJA | NAJA Legal Hotline for Journalists | NAJA Free Press Resource Page | NAJA to partner with SPJ, RTDNA for EIJ16 | UNITY-NAJA to host Regional Media Summit in Phoenix April 28-29 | NAJA calls for ethical, informed ICWA reporting | NAJA calls for 2016-2017 EIJ News interns / NAJ Fellows | Early-bird registration now open for EIJ16
The Native American Journalists Association serves and empowers Native journalists through programs and actions designed to enrich journalism and promote Native cultures.
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St. Gertrude the Great is invoked for souls in purgatory and for living sinners. Our Lord told St. Gertrude that the following prayer would release 1000 souls from purgatory each time it is ... continue reading
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St. James the Less, the author of the first Catholic Epistle, was the son of Alphaeus of Cleophas. His mother Mary was either a sister or a close relative of the Blessed Virgin, and for that reason, ... continue readingMore Saint of the Day
Mary, also known as St. Mary the Virgin, the Blessed Virgin Mary, Saint Mary, Mary Mother of God or the Virgin Mary is believed by many to be the greatest of all Christian saints. The Virgin Mother "was, after her Son, exalted by divine grace above all angels and ... continue readingMore Female Saints
Saint Michael the Archangel isn't a saint, but rather he is an angel, and the leader of all angels and of the army of God. This is what the title "Archangel" means, that he is above all the others in rank. St. Michael has four main responsibilities or offices, as we ... continue reading
Ava was the daughter of King Pepin. She was cured of blindness by St. Rainfredis, became a Benedictine nun at Dinart, Hainault, and later was elected Abbess. Her feast day is April 29th. continue reading
Founder of the Franciscan Order, born at Assisi in Umbria, in 1181. In 1182, Pietro Bernardone returned from a trip to France to find out his wife had given birth to a son. Far from being excited or apologetic because he'd been gone, Pietro was furious because she'd ... continue reading
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On September 4, 2016, Pope Francis will canonize Mother Teresa as a saint of the Roman Catholic Church. Her canonization is an important event for Catholics and all people around the world. Here's 3 reasons why. LOS ANGELES, CA (Catholic Online) - When Mother Teresa is ... continue readingMore Christian Saints & Heroes


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ArtFields 2016
The South's most engaging art competition and festival draws talent from across the Southeast to the heart of historic Lake City. Get ready for unforgettable family fun and world-class southern art.
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Nursing student gangraped in Rajasthan
Bundi: A 19-year-old nursing student was allegedly abducted and gangraped by unidentified youths when she had gone to a fun trip with her boyfriend in Dabalana
area near here on Saturday.
The incident took place when the girl, a student of a private nursing college in Bundi and a resident of Kota, and her boyfriend Rajendra Yadav were spending time together at a
secluded place on Phoolsager road below a TV tower.
Two youths reached there in a jeep, beat up the boyfriend, and forcibly took her in a nearby forest, they said, adding three other youths on a bike joined the duo there.
The two youths allegedly raped the girl, and later, one of the accused took the victim on his bike and left her on roadside at Jaipur-Kota National Highway.
Meanwhile, Rajendra Yadav, a car driver, reached the district police control room and narrated the whole incident.
Additional SP NL Pavan said the girl had admitted to have been raped by two men in the jungle below the TV tower on Phoolsager road.
The police has lodged a case of kidnapping and rape against the unidentified men and attempts were on to nab them, he said, adding the medical examination report of the victim was awaited.
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Recent Research Articles from UNTHSC
Enhancing nurses' knowledge regarding the complex care of hospitalized patients on insulin.
Enhancing nurses' knowledge regarding the complex care of hospitalized patients on insulin.
J Nurses Prof Dev. 2014 Jul-Aug;30(4):174-80
Authors: Wakefield PL, Wilson MA
A randomized controlled study assessed a self-paced, online educational course addressing the complex nursing care of hospitalized patients on basal-bolus insulin. Interactive quizzes and scenarios were used to reinforce learning. Knowledge in the intervention group increased significantly and was retained 3-months postintervention. Nursing professional development educators will find this article useful regarding methods for annual competency evaluation and for increasing staff's knowledge as part of a system approach for safely caring for patients with diabetes.
PMID: 24823888 [PubMed - indexed for MEDLINE]
Restoring lumbar spine stiffness using an interspinous implant in an ovine model of instability.
Restoring lumbar spine stiffness using an interspinous implant in an ovine model of instability.
Clin Biomech (Bristol, Avon). 2016 Feb 24;33:85-91
Authors: Szpalski M, Gunzburg R, Colloca CJ, Kosmopoulos V, Hegazy MA, Freeman BJ, Fabeck L
BACKGROUND: The objective of this study was to determine the effect of an interspinous implant on lumbar spine stability and stiffness during dorsoventral loading.
METHODS: Twelve Merino lambs were mechanically tested in vivo. Oscillatory (2Hz) loads were applied to L2 under load control while displacements were monitored. Tri-axial accelerometers further quantified adjacent L3-L4 accelerations. Dorsoventral lumbar spine stiffness and L3 and L4 dorsoventral and axial displacements were determined over six trials of 20cycles of loading. Four conditions were examined: 1) initial intact, 2) following destabilization at L3-L4, 3) following the insertion of an InSwing(®) interspinous device at L3-L4, and 4) with the implant secured with a tension band. Comparisons were performed using a one-way ANOVA with repeated measures and post-hoc Bonferroni correction.
FINDINGS: Compared to the intact condition, destabilization significantly decreased lumbar stiffness by 4.5% (P=.001) which was only recovered by the interspinous device with tension band. The interspinous device caused a significant 9.75% (P=.001) increase in dorsoventral stiffness from destabilization that increased 14% with the tension band added (P=.001). The tension band was responsible for decreased displacements from the intact (P=.038), instability (P=.001), and interspinous device (P=.005) conditions. Dorsoventral L3-L4 motion significantly improved with the interspinous device (P=.01) and the addition of the tension band (P=.001). No significant differences in L3-L4 intersegmental stability were noted for axial motion in the sagittal plane.
INTERPRETATION: This ovine model provided objective in vivo biomechanical evidence of lumbar instability and its restoration by means of an interspinous implant during dorsoventral spinal loading.
PMID: 26963708 [PubMed - as supplied by publisher]
Over-the-counter fish oil use in a county hospital: Medication use evaluation and efficacy analysis.
Over-the-counter fish oil use in a county hospital: Medication use evaluation and efficacy analysis.
J Clin Lipidol. 2015 May-Jun;9(3):326-33
Authors: Tatachar A, Pio M, Yeung D, Moss E, Chow D, Boatright S, Quinones M, Mathew A, Hulstein J, Adams-Huet B, Ahmad Z
BACKGROUND: Little is known about the use and effectiveness of over-the-counter (OTC) fish oil supplements for triglyceride (TG) lowering.
OBJECTIVES: To (1) perform a medication-use evaluation (MUE) and (2) assess the efficacy of OTC fish oil.
METHODS: Retrospective, observational cohort study using electronic medical records and the pharmacy database from Parkland Health and Hospital System in Dallas, Texas. Parkland is a tax-supported county institution that provides patients with single-brand OTC fish oil. Two separate analyses were conducted. Six hundred seventeen patients (prescribed fish oil between July 1, 2012, and August 31, 2012) were included in the MUE analysis and 235 patients (109 fish oil, 72 fenofibrate, and 54 gemfibrozil, prescribed between January 1, 2012, and July 31, 2013) were included in the efficacy analysis. The main outcome measure for the MUE was fish oil prescribing habits including dosages and patient adherence, as defined by medication possession ratio. The main outcome measure for the efficacy analysis was change in lipids measured using the last value before fish oil treatment and the first value after fish oil treatment.
RESULTS: MUE: 617 patients received prescriptions for OTC fish oil. Sixty-four percent were prescribed a total daily dose of 2000 mg. Only 25% of patients were adherent. Efficacy analysis: despite being prescribed suboptimal doses, fish oil reduced TGs by 29% (95% confidence interval, 34.3-22.7). Compared with fish oil therapy, fibrate therapy resulted in a greater TG reduction: 48.5% (55.1-41.0) with fenofibrate and 49.8% (57.6-40.5) with gemfibrozil (P < .0001, both medications compared with fish oil).
CONCLUSIONS: Health care providers prescribe suboptimal doses of fish oil, and adherence is poor. Even at low doses (2 g/d), though, fish oil lowers TGs by 29%.
PMID: 26073390 [PubMed - indexed for MEDLINE]
Coding ill-defined and unknown cause of death is 13 times more frequent in Denmark than in Finland.
Coding ill-defined and unknown cause of death is 13 times more frequent in Denmark than in Finland.
Forensic Sci Int. 2014 Nov;244:289-94
Authors: Ylijoki-Sørensen S, Sajantila A, Lalu K, Bøggild H, Boldsen JL, Boel LW
Exact cause and manner of death determination improves legislative safety for the individual and for society and guides aspects of national public health. In the International Classification of Diseases, codes R00-R99 are used for "symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified" designated as "ill-defined" or "with unknown etiology". The World Health Organisation recommends avoiding the use of ill-defined and unknown causes of death in the death certificate as this terminology does not give any information concerning the possible conditions that led to the death. Thus, the aim of the study was, firstly, to analyse the frequencies of R00-R99-coded deaths in mortality statistics in Finland and in Denmark and, secondly, to compare these and the methods used to investigate the cause of death. To do so, we extracted a random 90% sample of the Finnish death certificates and 100% of the Danish certificates from the national mortality registries for 2000, 2005 and 2010. Subsequently, we analysed the frequencies of forensic and medical autopsies and external clinical examinations of the bodies in R00-R99-coded deaths. The use of R00-R99 codes was significantly higher in Denmark than in Finland; OR 18.6 (95% CI 15.3-22.4; p<0.001) for 2000, OR 9.5 (95% CI 8.0-11.3; p<0.001) for 2005 and OR 13.2 (95% CI 11.1-15.7; p<0.001) for 2010. More than 80% of Danish deaths with R00-R99 codes were over 70 years of age at the time of death. Forensic autopsy was performed in 88.3% of Finnish R00-R99-coded deaths, whereas only 3.5% of Danish R00-R99-coded deaths were investigated with forensic or medical autopsy. The codes that were most used in both countries were R96-R99, meaning "unknown cause of death". In Finland, all of these deaths were investigated with a forensic autopsy. Our study suggests that if all deaths in all age groups with unclear cause of death were systematically investigated with a forensic autopsy, only 2-3/1000 deaths per year would be coded as an ill-defined and unknown cause of death in national mortality statistics. At the same time the risk to overlook unnatural deaths is decreased to a minimum. To achieve this in Denmark requires that the existing legislation on cause of death investigation would need to be changed to ensure that all deaths with unknown cause of death are investigated with a forensic autopsy.
PMID: 25300069 [PubMed - indexed for MEDLINE]
Autopsy rate in suicide is low among elderly in Denmark compared with Finland.
Autopsy rate in suicide is low among elderly in Denmark compared with Finland.
Forensic Sci Int. 2014 Nov;244:158-65
Authors: Ylijoki-Sørensen S, Boldsen JL, Boel LW, Bøggild H, Lalu K, Sajantila A
National differences in the legislation on cause and manner of death investigation are reflected in a high autopsy rate in suicides in Finland and a low corresponding rate in Denmark. The consequences for mortality statistics of these different investigation practices on deaths classified as suicides in Denmark and Finland, respectively, are not known in detail. The aim of this article was to analyse autopsy rates in deaths classified as suicides, and to identify any differences in investigation practices in deaths with a comparable cause of death, but classified as unnatural deaths other than suicide. Data from the mortality registries were summarised for the years 2000, 2005 and 2010. Autopsy rates (total, forensic and medical) were analysed with regard to deaths classified as suicide, and they were compared for three age groups (1-50 years, 51-70 years and ≥71 years) and for causes of death. Deaths classified as suicide were compared with other unnatural classifications, and comparable causes of death were coded into six subgroups: poisonings, suffocations/strangulations, firearm discharges, drowning/submersions, explosions/flames and other/unspecified causes. The total autopsy rate for suicides was 99.8% in Finland and 13.2% in Denmark. Almost all of these autopsies were conducted as forensic autopsies. In the age group ≥71 years, Danish suicides outnumbered Finnish suicides (410 versus 283). The total autopsy rate was lower in the more senior age group in Denmark (19.5%, 9.9%, 5.6%), whereas it was consistently high in Finland (99.8%, 99.9%, 99.6%). Among Danish deaths due to poisonings, the autopsy rate was 89.5% when these were classified as accidents, but only 20.7% for cases classified as suicides. The number of deaths in the two Danish subgroups was comparable (550 versus 553). In Denmark, the decision regarding the need, if any, for a forensic autopsy is made during the external forensic examination of the body. Our study showed that the limited use of forensic autopsy to confirm the cause of death in deaths classified as suicides raises doubts about the accuracy of the Danish suicide mortality statistics. Our finding is emphasised by those cases in which the cause of death was registered as intentional self-poisoning. The high number of suicides among the elderly in Denmark is striking and begs further investigation and research. Overall, our data from Finland and Denmark reveal striking differences between the two countries and warrant further comparative studies on the subject in other countries.
PMID: 25244292 [PubMed - indexed for MEDLINE]
Mycobacterium Tuberculosis Infection, Immigration Status, and Diagnostic Discordance: A Comparison of Tuberculin Skin Test and QuantiFERON(®)-TB Gold In-Tube Test Among Immigrants to the U.S.
Mycobacterium Tuberculosis Infection, Immigration Status, and Diagnostic Discordance: A Comparison of Tuberculin Skin Test and QuantiFERON(®)-TB Gold In-Tube Test Among Immigrants to the U.S.
Public Health Rep. 2016 Mar-Apr;131(2):303-10
Authors: Wilson FA, Miller TL, Stimpson JP
OBJECTIVE: We used a recent source of nationally representative population data on tuberculosis (TB) infection to characterize concordance between the tuberculin skin test (TST) and the QuantiFERON(®)-TB Gold In-Tube (QFT-GIT) blood test for immigrants in the United States.
METHODS: We used TB screening data from the 2011-2012 National Health and Nutrition Examination Survey to examine concordance between the TST and QFT-GIT-an interferon-gamma release assay (IGRA) blood test-for 7,097 U.S. natives, naturalized citizens, and noncitizens.
RESULTS: Consistent with prior findings, one in five immigrants in the survey was identified with latent TB infection (LTBI), a rate 14 times higher than for U.S. natives. We also found higher rates of discordant TST/IGRA results among immigrants than among U.S. natives. Unadjusted discordance between TST and IGRA was 3% among U.S. natives (weighted N=5,684,274 of 191,179,213) but ranged up to 19% for noncitizens (weighted N=3,722,960 of 19,377,147). Adjusting for age, sex, and race/ethnicity, noncitizens had more than nine times the odds of having a positive TST result but negative QFT-GIT result compared with U.S. natives.
CONCLUSIONS: Our findings suggest that whether and how either of these tests should be deployed is highly context sensitive. Significant discordance in test results when used among immigrants raises the possibility of missed opportunities for harm reduction in this already at-risk population. However, we found little distinction between the tests in terms of diagnostic outcome when used in a U.S. native population, suggesting little benefit to the adoption and use of the QFT-GIT test in place of TST on the basis of test performance alone for this population.
PMID: 26957665 [PubMed - in process]
Comparison of the Effectiveness of Interactive Didactic Lecture Versus Online Simulation-Based CME Programs Directed at Improving the Diagnostic Capabilities of Primary Care Practitioners.
Comparison of the Effectiveness of Interactive Didactic Lecture Versus Online Simulation-Based CME Programs Directed at Improving the Diagnostic Capabilities of Primary Care Practitioners.
J Contin Educ Health Prof. 2016;36(1):32-7
Authors: McFadden P, Crim A
INTRODUCTION: Diagnostic errors in primary care contribute to increased morbidity and mortality, and billions in costs each year. Improvements in the way practicing physicians are taught so as to optimally perform differential diagnosis can increase patient safety and lower the costs of care. This study represents a comparison of the effectiveness of two approaches to CME training directed at improving the primary care practitioner's diagnostic capabilities against seven common and important causes of joint pain.
METHODS: Using a convenience sampling methodology, one group of primary care practitioners was trained by a traditional live, expert-led, multimedia-based training activity supplemented with interactive practice opportunities and feedback (control group). The second group was trained online with a multimedia-based training activity supplemented with interactive practice opportunities and feedback delivered by an artificial intelligence-driven simulation/tutor (treatment group).
RESULTS: Before their respective instructional intervention, there were no significant differences in the diagnostic performance of the two groups against a battery of case vignettes presenting with joint pain. Using the same battery of case vignettes to assess postintervention diagnostic performance, there was a slight but not statistically significant improvement in the control group's diagnostic accuracy (P = .13). The treatment group, however, demonstrated a significant improvement in accuracy (P < .02; Cohen d, effect size = 0.79).
DISCUSSION: These data indicate that within the context of a CME activity, a significant improvement in diagnostic accuracy can be achieved by the use of a web-delivered, multimedia-based instructional activity supplemented by practice opportunities and feedback delivered by an artificial intelligence-driven simulation/tutor.
PMID: 26954243 [PubMed - in process]
The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.
The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.
Mol Biol Evol. 2015 Mar;32(3):661-73
Authors: Hallast P, Batini C, Zadik D, Maisano Delser P, Wetton JH, Arroyo-Pardo E, Cavalleri GL, de Knijff P, Destro Bisol G, Dupuy BM, Eriksen HA, Jorde LB, King TE, Larmuseau MH, López de Munain A, López-Parra AM, Loutradis A, Milasin J, Novelletto A, Pamjav H, Sajantila A, Schempp W, Sears M, Tolun A, Tyler-Smith C, Van Geystelen A, Watkins S, Winney B, Jobling MA
Many studies of human populations have used the male-specific region of the Y chromosome (MSY) as a marker, but MSY sequence variants have traditionally been subject to ascertainment bias. Also, dating of haplogroups has relied on Y-specific short tandem repeats (STRs), involving problems of mutation rate choice, and possible long-term mutation saturation. Next-generation sequencing can ascertain single nucleotide polymorphisms (SNPs) in an unbiased way, leading to phylogenies in which branch-lengths are proportional to time, and allowing the times-to-most-recent-common-ancestor (TMRCAs) of nodes to be estimated directly. Here we describe the sequencing of 3.7 Mb of MSY in each of 448 human males at a mean coverage of 51×, yielding 13,261 high-confidence SNPs, 65.9% of which are previously unreported. The resulting phylogeny covers the majority of the known clades, provides date estimates of nodes, and constitutes a robust evolutionary framework for analyzing the history of other classes of mutation. Different clades within the tree show subtle but significant differences in branch lengths to the root. We also apply a set of 23 Y-STRs to the same samples, allowing SNP- and STR-based diversity and TMRCA estimates to be systematically compared. Ongoing purifying selection is suggested by our analysis of the phylogenetic distribution of nonsynonymous variants in 15 MSY single-copy genes.
PMID: 25468874 [PubMed - indexed for MEDLINE]
Preterm birth and air pollution: Critical windows of exposure for women with asthma.
Preterm birth and air pollution: Critical windows of exposure for women with asthma.
J Allergy Clin Immunol. 2016 Feb 23;
Authors: Mendola P, Wallace M, Hwang BS, Liu D, Robledo C, Mӓnnistӧ T, Sundaram R, Sherman S, Ying Q, Grantz KL
BACKGROUND: Ambient air pollutants may increase preterm birth (PTB) risk, but critical exposure windows are uncertain. The interaction of asthma and pollutant exposure is rarely studied.
OBJECTIVE: We sought to assess the interaction of maternal asthma and air pollutant exposures in relation to PTB risk.
METHODS: Electronic medical records for 223,502 US deliveries were linked with modified Community Multiscale Air Quality model outputs. Logistic regression with generalized estimating equations estimated the odds ratio and 95% CIs for PTB on the basis of the interaction of maternal asthma and particulate matter with aerodynamic diameter of less than 2.5 microns and particulate matter with aerodynamic diameter of less than 10 microns, ozone (O3), nitrogen oxides (NOx), sulfur dioxide (SO2), and carbon monoxide (CO) per interquartile range. For each gestational week 23 to 36, exposures among women who delivered were compared with those remaining pregnant. Three-month preconception, whole pregnancy, weeks 1 to 28, and the last 6 weeks of gestation averages were also evaluated.
RESULTS: On assessing PTB by gestational week, we found that significant asthma interactions were sporadic before 30 weeks but more common during weeks 34 to 36, with higher risk among mothers with asthma for NOx, CO, and SO2 exposure and an inverse association with O3 in week 34. Odds of PTB were significantly higher among women with asthma for CO and NOx exposure preconception and early in pregnancy. In the last 6 weeks of pregnancy, PTB risk associated with particulate matter with aerodynamic diameter of less than 10 microns was higher among women with asthma.
CONCLUSIONS: Mothers with asthma may experience a higher risk for PTB after exposure to traffic-related pollutants such as CO and NOx, particularly for exposures 3-months preconception and in the early weeks of pregnancy.
PMID: 26944405 [PubMed - as supplied by publisher]
DNA quality and quantity from up to 16 years old post-mortem blood stored on FTA cards.
DNA quality and quantity from up to 16 years old post-mortem blood stored on FTA cards.
Forensic Sci Int. 2016 Feb 23;261:148-153
Authors: Rahikainen AL, Palo JU, de Leeuw W, Budowle B, Sajantila A
Blood samples preserved on FTA cards offer unique opportunities for genetic research. DNA recovered from these cards should be stable for long periods of time. However, it is not well established as how well the DNA stored on FTA card for substantial time periods meets the demands of forensic or genomic DNA analyses and especially so for from post-mortem (PM) samples in which the quality can vary upon initial collection. The aim of this study was to evaluate the time-dependent degradation on DNA quality and quantity extracted from up to 16 years old post-mortem bloodstained FTA cards. Four random FTA samples from eight time points spanning 1998 to 2013 (n=32) were collected and extracted in triplicate. The quantity and quality of the extracted DNA samples were determined with Quantifiler(®) Human Plus (HP) Quantification kit. Internal sample and sample-to-sample variation were evaluated by comparing recovered DNA yields. The DNA from the triplicate samplings were subsequently combined and normalized for further analysis. The practical effect of degradation on DNA quality was evaluated from normalized samples both with forensic and pharmacogenetic target markers. Our results suggest that (1) a PM change, e.g. blood clotting prior to sampling, affects the recovered DNA yield, creating both internal and sample-to-sample variation; (2) a negative correlation between the FTA card storage time and DNA quantity (r=-0.836 at the 0.01 level) was observed; (3) a positive correlation (r=0.738 at the level 0.01) was found between FTA card storage time and degradation levels. However, no inhibition was observed with the method used. The effect of degradation was manifested clearly with functional applications. Although complete STR-profiles were obtained for all samples, there was evidence of degradation manifested as decreased peak heights in the larger-sized amplicons. Lower amplification success was notable with the large 5.1kb CYP2D6 gene fragment which strongly supports degradation of the stored samples. According to our results, DNA stored on FTA cards is rather stable over a long time period. DNA extracted from this storage medium can be used as human identification purposes as the method used is sufficiently sensitive and amplicon sizes tend to be <400bp. However, DNA integrity was affected during storage. This effect should be taken into account depending on the intended application especially if high quality DNA and long PCR amplicons are required.
PMID: 26937857 [PubMed - as supplied by publisher]
Canonical transient receptor potential 6 (TRPC6) channel, a new target of reactive oxygen species in renal physiology and pathology.
Canonical transient receptor potential 6 (TRPC6) channel, a new target of reactive oxygen species in renal physiology and pathology.
Antioxid Redox Signal. 2016 Mar 3;
Authors: Ma R, Chaudhari S, Li W
SIGNIFICANCE: Regulation of Ca2+ signaling cascade by reactive oxygen species (ROS) is becoming increasingly evident and this regulation represents a key mechanism for control of many fundamental cellular functions. Canonical transient receptor potential (TRPC) 6, a member of Ca2+ conductive channel in TRPC family, is widely expressed in kidney cells, including glomerular mesangial cells, podocytes, tubular epithelial cells and vascular myocytes in renal microvasculatures. Both overproduction of ROS and dysfunction of TRPC6 channel are involved in renal injury in animal models and human subjects. Although regulation of TRPC channel function by ROS has been well described in other tissues and cell types, such as vascular smooth muscle, this important cell regulatory mechanism has not been fully reviewed in kidney cells. Recent Advances: Accumulating evidence has shown that TRPC6 is a redox-sensitive channel, and modulation of TRPC6 Ca2+ signaling by altering TRPC6 protein expression or TRPC6 channel activity in kidney cells is a downstream mechanism by which ROS induce renal damage.
CRITICAL ISSUES: This review highlights how recent studies analyzing function and expression of TRPC6 channels in kidney and their response to ROS improve our mechanistic understanding of oxidative stress-related kidney diseases.
FUTURE DIRECTIONS: Although it is evident that ROS regulate TRPC6-mediated Ca2+ signaling in several types of kidney cells, further study is needed to identify the underlying molecular mechanism. We hope that the newly-identified ROS/TRPC6 pathway will pave the way to new, promising therapeutic strategies to target kidney diseases such as diabetic nephropathy.
PMID: 26937558 [PubMed - as supplied by publisher]
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
Drug Metab Dispos. 2016 Mar 2;
Authors: Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS
Marketed drugs cleared by aldehyde oxidase (AO) are few, with no known clinically relevant pharmacokinetic drug interactions associated with AO inhibition, while cytochrome P450 inhibition or induction mediates a number of clinical drug interactions. Little attention has been given to consequences of co-administering a P450 inhibitor with a compound metabolized by both AO and P450. Upon discovering that VU0409106 ( 1: ) was metabolized by AO (to M1) and P450 enzymes (to M4-M6), we sought to evaluate the in vivo disposition of 1: and its metabolites in rats with attenuated P450 activity. Male rats were orally pretreated with the pan-P450 inactivator, 1-aminobenzotriazole (ABT), prior to an intraperitoneal dose of 1: . Interestingly, the plasma(AUC)of M1 was increased 15-fold in ABT-treated rats, indicating a metabolic shunt towards AO resulted from the drug interaction condition. The AUC of 1: also increased 7.8-fold. Accordingly, plasma clearance of 1: decreased from 53.5 to 15.3 mL/min/kg in ABT-pretreated rats receiving an intravenous dose of 1: . Consistent with these data, M1 formation in hepatic S9 increased with NADPH-exclusion to eliminate P450 activity (50% over reactions containing NADPH). These studies reflect possible consequences of a drug interaction between P450 inhibitors and compounds cleared by both AO and P450 enzymes. Notably, increased exposure to an AO metabolite may hold clinical relevance for active metabolites or those mediating toxicity at elevated concentrations. The recent rise in clinical drug candidates metabolized by AO underscores the importance of these findings and the need for clinical studies to fully understand these risks.
PMID: 26936972 [PubMed - as supplied by publisher]
Racial disparities in reaching the renal transplant waitlist: is geography as important as race?
Racial disparities in reaching the renal transplant waitlist: is geography as important as race?
Clin Transplant. 2015 Jun;29(6):531-8
Authors: Saunders MR, Lee H, Alexander GC, Tak HJ, Thistlethwaite JR, Ross LF
BACKGROUND: In the United States, African Americans and whites differ in access to the deceased donor renal transplant waitlist. The extent to which racial disparities in waitlisting differ between United Network for Organ Sharing (UNOS) regions is understudied.
METHODS: The US Renal Data System (USRDS) was linked with US census data to examine time from dialysis initiation to waitlisting for whites (n = 188,410) and African Americans (n = 144,335) using Cox proportional hazards across 11 UNOS regions, adjusting for potentially confounding individual, neighborhood, and state characteristics.
RESULTS: Likelihood of waitlisting varies significantly by UNOS region, overall and by race. Additionally, African Americans face significantly lower likelihood of waitlisting compared to whites in all but two regions (1 and 6). Overall, 39% of African Americans with ESRD reside in Regions 3 and 4--regions with a large racial disparity and where African Americans comprise a large proportion of the ESRD population. In these regions, the African American-white disparity is an important contributor to their overall regional disparity.
CONCLUSIONS: Race remains an important factor in time to transplant waitlist in the United States. Race contributes to overall regional disparities; however, the importance of race varies by UNOS region.
PMID: 25818547 [PubMed - indexed for MEDLINE]
A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium.
A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium.
Bioorg Med Chem Lett. 2015;25(10):2065-7
Authors: Mukerjee A, Iyidogan P, Castellanos-Gonzalez A, Cisneros JA, Czyzyk D, Ranjan AP, Jorgensen WL, White AC, Vishwanatha JK, Anderson KS
Cryptosporidiosis, a gastrointestinal disease caused by protozoans of the genus Cryptosporidium, is a common cause of diarrheal diseases and often fatal in immunocompromised individuals. Bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis (C. hominis) has been a molecular target for inhibitor design. C. hominis TS-DHFR inhibitors with nM potency at a biochemical level have been developed however drug delivery to achieve comparable antiparasitic activity in Cryptosporidium infected cell culture has been a major hurdle for designing effective therapies. Previous mechanistic and structural studies have identified compound 906 as a nM C. hominis TS-DHFR inhibitor in vitro, having μM antiparasitic activity in cell culture. In this work, proof of concept studies are presented using a nanotherapy approach to improve drug delivery and the antiparasitic activity of 906 in cell culture. We utilized PLGA nanoparticles that were loaded with 906 (NP-906) and conjugated with antibodies to the Cryptosporidium specific protein, CP2, on the nanoparticle surface in order to specifically target the parasite. Our results indicate that CP2 labeled NP-906 (CP2-NP-906) reduces the level of parasites by 200-fold in cell culture, while NP-906 resulted in 4.4-fold decrease. Moreover, the anticryptosporidial potency of 906 improved 15 to 78-fold confirming the utility of the antibody conjugated nanoparticles as an effective drug delivery strategy.
PMID: 25900220 [PubMed - indexed for MEDLINE]
Discriminative and locomotor effects of five synthetic cathinones in rats and mice.
Discriminative and locomotor effects of five synthetic cathinones in rats and mice.
Psychopharmacology (Berl). 2015 Apr;232(7):1197-205
Authors: Gatch MB, Rutledge MA, Forster MJ
RATIONALE: Synthetic cathinones continue to be sold as "legal" alternatives to methamphetamine or cocaine. As these marginally legal compounds become controlled, suppliers move to other, unregulated compounds.
OBJECTIVES: The purpose of these experiments was to determine whether several temporarily controlled cathinone compounds, which are currently abused on the street, stimulate motor activity and have discriminative stimulus effects similar to cocaine and/or methamphetamine.
METHODS: Methcathinone, pentedrone, pentylone, 3-fluoromethcathinone (3-FMC), and 4-methylethcathinone (4-MEC) were tested for locomotor stimulant effects in mice and subsequently for substitution in rats trained to discriminate cocaine (10 mg/kg, i.p.) or methamphetamine (1 mg/kg, i.p.) from saline.
RESULTS: Methcathinone, pentedrone, and pentylone produced locomotor stimulant effects which lasted up to 6 h. In addition, pentylone produced convulsions and lethality at 100 mg/kg. 4-MEC produced locomotor stimulant effects which lasted up to 2 h. Methcathinone, pentedrone, pentylone, 3-FMC, and 4-MEC each produced discriminative stimulus effects similar to those of cocaine and methamphetamine.
CONCLUSIONS: All of the tested compounds produce discriminative stimulus effects similar to either those of cocaine, methamphetamine, or both, which suggests that these compounds are likely to have similar abuse liability to cocaine and/or methamphetamine. Pentylone may be more dangerous on the street, as it produced adverse effects at doses that produced maximal stimulant-like effects.
PMID: 25281225 [PubMed - indexed for MEDLINE]
Current perspectives on the link between neuroinflammation and neurogenesis.
Current perspectives on the link between neuroinflammation and neurogenesis.
Metab Brain Dis. 2015 Apr;30(2):355-65
Authors: Wang B, Jin K
The link between neuroinflammation and neurogenesis is an area of intensive research in contemporary neuroscience. The burgeoning amount of evidence accumulated over the past decade has been incredible, and now there remains the figuring out of minutia to give us a more complete picture of what individual, synergistic, and antagonistic events are occurring between neurogenesis and neuroinflammation. An intricate study of the inflammatory microenvironment influenced by the presence of the various inflammatory components like cytokines, chemokines, and immune cells is essential for: 1) understanding how neurogenesis can be affected in such a specialized niche and 2) applying the knowledge gained for the treatment of cognitive and/or motor deficits arising from inflammation-associated diseases like stroke, traumatic brain injury, Alzheimer's disease, and Parkinson's disease. This review is written to provide the reader with up-to-date information explaining how these inflammatory components are effecting changes on neurogenesis.
PMID: 24623361 [PubMed - indexed for MEDLINE]
Cerebrospinal Fluid Levels of Monoamine Metabolites in the Epileptic Baboon.
Cerebrospinal Fluid Levels of Monoamine Metabolites in the Epileptic Baboon.
Primates. 2015 Dec;4(2)
Authors: Szabó CÁ, Patel M, Uteshev VV
The baboon represents a natural model for genetic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). In this retrospective study, cerebrospinal fluid (CSF) monoamine metabolites and scalp electroencephalography (EEG) were evaluated in 263 baboons of a pedigreed colony. CSF monoamine abnormalities have been linked to reduced seizure thresholds, behavioral abnormalities and SUDEP in various animal models of epilepsy. The levels of 3-hydroxy-4-methoxyphenylglycol, 5-hydroxyindolacetic acid and homovanillic acid in CSF samples drawn from the cisterna magna were analyzed using high-performance liquid chromatography. These levels were compared between baboons with seizures (SZ), craniofacial trauma (CFT) and asymptomatic, control (CTL) baboons, between baboons with abnormal and normal EEG studies. We hypothesized that the CSF levels of major monoaminergic metabolites (i.e., dopamine, serotonin and norepinephrine) associate with the baboons' electroclinical status and thus can be used as clinical biomarkers applicable to seizures/epilepsy. However, despite apparent differences in metabolite levels between the groups, usually lower in SZ and CFT baboons and in baboons with abnormal EEG studies, we did not find any statistically significant differences using a logistic regression analysis. Significant correlations between the metabolite levels, especially between 5-HIAA and HVA, were preserved in all electroclinical groups. While we were not able to demonstrate significant differences in monoamine metabolites in relation to seizures or EEG markers of epilepsy, we cannot exclude the monoaminergic system as a potential source of pathogenesis in epilepsy and SUDEP. A prospective study evaluating serial CSF monoamine levels in baboons with recently witnessed seizures, and evaluation of abnormal expression and function of monoaminergic receptors and transporters within epilepsy-related brain regions, may impact the electroclinical status.
PMID: 26924854 [PubMed - as supplied by publisher]
Level of Immersion in Virtual Environments Impacts the Ability to Assess and Teach Social Skills in Autism Spectrum Disorder.
Level of Immersion in Virtual Environments Impacts the Ability to Assess and Teach Social Skills in Autism Spectrum Disorder.
Cyberpsychol Behav Soc Netw. 2016 Feb 26;
Authors: Miller HL, Bugnariu NL
Virtual environments (VEs) may be useful for delivering social skills interventions to individuals with autism spectrum disorder (ASD). Immersive VEs provide opportunities for individuals with ASD to learn and practice skills in a controlled replicable setting. However, not all VEs are delivered using the same technology, and the level of immersion differs across settings. We group studies into low-, moderate-, and high-immersion categories by examining five aspects of immersion. In doing so, we draw conclusions regarding the influence of this technical manipulation on the efficacy of VEs as a tool for assessing and teaching social skills. We also highlight ways in which future studies can advance our understanding of how manipulating aspects of immersion may impact intervention success.
PMID: 26919157 [PubMed - as supplied by publisher]
Empirical testing of a 23-AIMs panel of SNPs for ancestry evaluations in four major US populations.
Empirical testing of a 23-AIMs panel of SNPs for ancestry evaluations in four major US populations.
Int J Legal Med. 2016 Feb 25;
Authors: Zeng X, Warshauer DH, King JL, Churchill JD, Chakraborty R, Budowle B
Ancestry informative markers (AIMs) can be used to determine population affiliation of the donors of forensic samples. In order to examine ancestry evaluations of the four major populations in the USA, 23 highly informative AIMs were identified from the International HapMap project. However, the efficacy of these 23 AIMs could not be fully evaluated in silico. In this study, these 23 SNPs were multiplexed to test their actual performance in ancestry evaluations. Genotype data were obtained from 189 individuals collected from four American populations. One SNP (rs12149261) on chromosome 16 was removed from this panel because it was duplicated on chromosome 1. The resultant 22-AIMs panel was able to empirically resolve the four major populations as in the in silico study. Eight individuals were assigned to a different group than indicated on their samples. The assignments of the 22 AIMs for these samples were consistent with AIMs results from the ForenSeq(TM) panel. No departures from Hardy-Weinberg equilibrium (HWE) and linkage disequilibrium (LD) were detected for all 22 SNPs in four US populations (after removing the eight problematic samples). The principal component analysis (PCA) results indicated that 181 individuals from these populations were assigned to the expected groups. These 22 SNPs can contribute to the candidate AIMs pool for potential forensic identification purposes in major US populations.
PMID: 26914801 [PubMed - as supplied by publisher]
Expansion of Microbial Forensics.
Expansion of Microbial Forensics.
J Clin Microbiol. 2016 Feb 24;
Authors: Schmedes SE, Sajantila A, Budowle B
Microbial forensics has been defined as the discipline of applying scientific methods to analyzing evidence related to bioterrorism, biocrimes, hoaxes, or the accidental release of a biological agent or toxin for attribution purposes. Over the past 15 years technology, particularly massively parallel sequencing, and bioinformatics advances now allow characterization of microorganisms for a variety of human forensic applications, such as human identification, body fluid characterization, post-mortem interval estimation, and biocrimes involving tracking of infectious agents. Thus, microbial forensics should be more broadly described as the discipline of applying scientific methods to analyzing microbial evidence in criminal and civil cases for investigative purposes.
PMID: 26912746 [PubMed - as supplied by publisher]


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Posted 12/22/2014 at 7:05 PM by Christina
I really love the personalized ornament I ordered. We had one little problem with some incorrect spelling BUT I notified the company and it was taken care of ASAP. I received the new one before Xmas. Will order again from here.
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Godson Christmas Ornament
Personalized Christmas Ornament
He has been baptized and you have been given the task of raising him in the church to give him a solid foundation for life. Godsons are very special boys in our lives. You have been chosen to help guide him on his spiritual journey. This personalized Godson Christmas ornament is painted with a male angel who is holding an envelope sealed with a blue heart. Printed on the envelope is GODSONS ARE SENT FROM HEAVEN ABOVE. We will love to personalize it with his name and a message from you too! Wonderful gift to give him for his Baptism, Communion or Confirmation.
Material: Glass ball
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Second City alumni include Dan Aykroyd, John Belushi and Steve Carell — and that's just the alphabet's first three letters. Basically, anybody who has made you laugh since the 1960s — Chris Farley, Tina Fey, Tim Meadows, Bill Murray, Joan Rivers — has some ties to Second City.
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Shin Bet apparently tracked the package after wondering at an enormous quantity of salt ordered by a Gaza importer with Hamas ties.18:10 03.05.16 | 0 comments
Nasrallah has got what he deserves. In Lebanon, his political situation is now very depending on national issues, he cannot act independently from Siniora, not even his alliance with Aoun (christian) is helping him no more, alliance that was concluded before the war already. That he is persecuted by other arab secret services tells a lot about his real estime in arab world. He is more than only a pain in the ass of the Israelis, arab shiad-islamists shouldn't forget this. I feel quite at ease seeing him in a suffering state!


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realmagick.com The shrine of knowledge.
Victoria Australia Religion
A selection of articles related to victoria australia religion.
Original articles from our library related to the Victoria Australia Religion. See Table of Contents for further available material (downloadable resources) on Victoria Australia Religion.
- The Religious Experience: A Wiccan Viewpoint
- What is religion? Religion is a set of beliefs which allow us to understand and categorize our world and our place in it. A set of beliefs which define our culture, our expectations, our views of people and behaviors we expect. I have found several different...
Religion & Philosophy >> Religions
- Aspects of Religion: A Wiccan Viewpoint
- Among early Pagans, religion was a fact taken for granted, "requiring no explanation." There was no need to define religion because religion was a part of each persons being. "We have not yet encountered in Egyptian and Babylonian literature a...
Religion & Philosophy >> Religions
- A Basic View of Paganism or Bambi Pagansim
- "You people are all so nice! I like the idea of Paganism, but I don't think I could be that nice all the time." The writer was genuinely perplexed and driven to ask me if it is really possible that Pagans, Witches and Wiccans really lived such...
Religions >> Paganism & Wicca
- Autonomous Spirituality and the Art of Being Your Own God
- As we continue to develop in our religious thinking, we have begun to move away from the old mythological, doctrinal and heteronomous, externally controlling religions, and towards autonomous religion, totally relevant to the individual who develops himself...
Religion & Philosophy >> Religions
- Asatru, an Ancient Religion Reborn
- "Asatru" (often known as "Heathenism," "Germanic Paganism," "Elder Troth," and other names) means "faith in the Aesir", which are the Gods of pre-Christian Scandinavia. The other Germanic peoples (Goths,...
Religions >> Asatru
Victoria Australia Religion is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Victoria Australia Religion books and related discussion.
Suggested Pdf Resources
- Chapter 4: Freedom of religion and belief in Australia - Parliament of ...
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- Chapter Four Religion and Belief in Contemporary Australia: Other Issues. 74 .... D Haveric, Australia in Muslim discovery, Lietelinna Press, Victoria, 2007.
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According to a recent survey of corporate legal departments by BTI Consulting Group, 2016 will see a fewer number of pending cases as a result of
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South Dakota AG Marty Jackley, president of the National Association of Attorneys General ("NAAG"), announced the formation of the NAAG Charities
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In response to consumer complaints, Ohio AG Mike DeWine is investigating businesses for any possible bottled water price gouging during the city of
Competition authorities around the world are vigorously pursuing domestic and international conspiracies and other anticompetitive activities. Focus


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You are a fan of capture gaming ? Come to discover the best forums capture gaming on the internet and share your experience with a community fan of capture gaming . You can also build a forum capture gaming and create your online discussion.
Free RP Forum: Where Fantasy and lore meet Sci-fi. Legends become real and the imagination runs wild. And much much more!
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sun in wrong place...cant believe im even thinking it...tell me when i made the mistake....uk
Poster Handle
Post Content
Now do you
think people opening up here about experiences like this are idiots?
Anonymous Coward 29130142
No, just mistaken.
I'm 40 years old with IQ of 144 and I've been familiar with more than just the basics of astronomy since childhood. You think I would't be aware of sun's position changing during the time of the year?
Anonymous Coward 29130142
No, just the extent of it and how "unusual" it looks at the extreme ends of travel.
Come on, I live in a country where it's basically pitch dark half of the year because of this.
Anonymous Coward 29130142
Have any pics of previous years showing the sun setting in a different place on the same date in previous years?
Don't know about others posting here, but the impression I'm getting from how they express themselves, they're not tards either.
Anonymous Coward 29130142
No, just mistaken, but it is their insistence that they can't be wrong in spite of the world's astronomers not noticing that makes them "tards".
So, we should all just believe what "people are telling us"
Anonymous Coward 29130142
What people? Astronomers? I daresay none of these "sun out of place" folks have even spoken to an astronomer. If they had, they might understand why they are wrong.
instead of
trusting what we see with our own eyes
and can reflect upon years of experiences of how things have been before? Not going to happen.
Anonymous Coward 29130142
As always, it is NOT ABOUT WHAT YOU SEE WITH YOUR EYES! It is about WHAT YOU THINK YOU REMEMBER! And... none of you EVER have any photos from previous years to support WHAT YOU THINK YOU REMEMBER!
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how much are you up by now?
no it was a tweet by Adam Feuerstein. Adam Feuerstein Tweets: @Mooshu69 @IraBidermanDDS Open label, uncontrolled data to 12 mos? Who cares? Only valid data are 28-day vs placebo. No difference. $GNCA
a$$man will take this pos private. thats the only way he can recoup his investment


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So it's all over the place that Jay Z was attacked by Solange Knowles in an elevator at the Standard Hotel in New York, after the Met Gala last week. Now I thought it was just going to be some boring slappy slappy type of incident, but OH no no no my friends, Beyonce's sister Solange tried to "bring the pain!"
No joke, whatever happened before they all got into the elevator must have really pissed Solange off because as soon at they got in she was in Jay's face with some, probably, choice words (there is no audio), and then proceeded to Sasha Fierce Jay Z's face. The crazy thing to me is Beyonce was having no part in "that" and basically just watched the attempted beat down of her hubby. I've posted the footage TMZ, somehow, got a hold of for you.
No one has said what sparked the incident, and the hotel is looking into how and who leaked the elevator recording calling it a breach of security and guest confidentiality.
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I know, and its still free, can you believe it?
This member has provided no bio about themself...
I know, and its still free, can you believe it?
Crazys back
Maybe for now try to reduce your resolution
yeah like when we added notes before to turn off actor legs and do this and that and still we get reports that people don't hear footsteps. People don't read...get it?
Not to mention that if we give a release date and don't meet it, people go mental like we have some contractual obligation to fill....you get that too?
Damnit greben, why can't people talk to you after you give them a task? :D
Game has it, youre not looking hard enough :)
Problem is you never used the patch
Oh the irony
No need to know anyone, LA has own spawn menu, in ui_main_menu.script just uncomment these lines :
--/ -- for tests and debug ------
elseif dik == DIK_keys.DIK_F1 then --/#+# (add.options)
elseif dik == DIK_keys.DIK_F2 then --/#+#(debug tools)
elseif dik == DIK_keys.DIK_F3 then --/#+# (debug spawn)
Well its not a bug if you use demo_record and mess it up now is it?
Actually the game is fixed, I just wait for you to blow a gasket before release. So you are still playing, which means what? Your comment about leaving the game was a lie? It was an idle threat? Are we supposed to be like "ermagerd ezeht will stop playing if we don't release patch soon, code red people" smart *** indeed.
Did you use demo_record anywhere?
Download and play?
I thought you were leaving LA to play games that "work"
You will need the tools for a side task, the pdas I've made dropable now.
Don't complain, just report.
You're still waiting and the game is still free.
Most don't like the gasmask hud. I`ve added a hud timer so you can see how much time is left.
I fixed AI, and I made heli patrol not as often and changed the sounds. Not sure about detector, I guess its a matter of preference.
Not a bug.
IIRC it is already in the first patch g_unlimitedammo
Changelog for second patch is here : Pastebin.ca
Check the changelog for the second patch here :
We've made good progress, it will be out a bit later this week, still testing.
I bet you played SOC through about 300 times like most of us, not sure why starting a new game is a problem for a true stalker :)
Really don't understand why that bothers you. People can put stuff in a stash at any time can't they?
Ivancov can fix stuff. And I`ve fixed skinflint in the next patch.
Incorrect, the bridge soldiers clearly communicate with you.


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In some women, high levels of progesterone and other progestin hormones may decrease the body's sensitivity to insulin. High levels of estrogen tend to improve insulin sensitivity. As you start the transition of menopause, you'll want to pay close attention to the effects it will have on your blood glucose levels.
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Google explains account deletion - tells us to keep it real
Google has responded to controversy over account deletions from its new Google+ social network, laying out future plans to stop accidental profile suspensions.
A post by Google's own Robert Scoble explains a conversation had with Vic Gundotra, the company's senior vice president of engineering, regarding account management.
"He says they have made some mistakes while doing the first pass at this and they are learning. He also says the team will change how they communicate with people. IE, let them know what they are doing wrong, etc." explained Scoble.
This should, in theory, mean plenty of prior warning before your account is deleted. Those who have unusual nicknames or spell their names using different characters, should hopefully now find Google warns them if they have their account flagged.
Section 13 of the company's User Content and Conduct Policy outlines exactly why accounts began disappearing:
"To help fight spam and prevent fake profiles, use the name your friends, family or co-workers usually call you. For example, if your full legal name is Charles Jones Jr. but you normally use Chuck Jones or Junior Jones, either of those would be acceptable."
Scoble said he pushed for a better appeals process and explains that Gundotra is well aware that mistakes were made the first time round. Gundotra also said that he is working on getting Google+ pseudonym savvy.
Bradley Horowitz, Google+'s VP of product, further cleared up Google's approach to accounts with a post following on from Scoble's.
He mentioned that Google are looking at ways of improving the signup process, meaning that problems will be less likely in the future. Finally Horowitz debunked the myth that a Google+ suspension leads to your entire Google account being blocked.
Google+ is still in its infancy, taking baby steps towards improvements that will likely bring the social network up to speed with competitors. Crucially the company still hasn't begun supporting proper Google apps accounts, nor has it begun to integrate many of its other services. Once the ball gets rolling however, and + begins to take on all of Google's products, expect a social network like no other.
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Do you love working with mixed media to create paper crafts with dynamic dimension and irresistible texture? This tutorial was made for you! Follow along to make a fun, personalized project to decorate your home or give as a gift.Read more »
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Koran Burner Fired From His Job In New Jersey
6 years ago
The protester who burned pages from the Koran outside a planned mosque near Ground Zero has been fired from NJTransit, sources and authorities said Tuesday.
Derek Fenton's 11-year career at the agency came to an abrupt halt Monday after photographs of him ripping pages from the Muslim holy book and setting them ablaze appeared in newspapers.
Fenton, 39, of Bloomingdale, N.J., burned the book during a protest on the ninth anniversary of Sept. 11 outside Park51, the controversial mosque slated to be built near Ground Zero.
He was apparently inspired by Pastor Terry Jones, the Florida clergyman who threatened to burn the Koran that day but later changed his mind.
NJ Transit said Fenton was fired but wouldn't give specifics.
"Mr. Fenton's public actions violated New Jersey Transit's code of ethics," an agency statement said.
"NJ Transit concluded that Mr. Fenton violated his trust as a state employee and therefore [he] was dismissed."
Click here to view photos:
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The Whitnall School District's new plan to give teachers time to collaborate by adjusting school start and release times may get revamped.
District officials have considered letting elementary students out of school early on certain days and having school start late for middle and high school students some days. But that may depend on the results of a parent survey that the School Board approved Monday night.
Some parents have been vocal about the problems the plan, which is expected to take effect this fall, could pose for their family schedules ever since the board approved it in January.
Although school officials are developing programs for children who would have to stay in school on those early release days, some parents and even some School Board members said they wanted to know more about that before they could support the plan.
All those objections were voiced Monday, which spurred the board to suggest gathering parental input through a survey on the start and release times. The survey results should come back to the School Board in April.
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