text:
Daniel Perez and Thomas Herrmann contributed equally to this work.
Cancer Cell Biology
Cancer testis antigen expression in gastrointestinal stromal tumors: New markers for early recurrence
Article first published online: 21 JUL 2008
DOI: 10.1002/ijc.23698
Copyright © 2008 Wiley-Liss, Inc.
International Journal of Cancer
Volume 123, Issue 7, pages 1551–1555, 1 October 2008
Additional Information
How to Cite
Perez, D., Herrmann, T., Jungbluth, A. A., Samartzis, P., Spagnoli, G., Demartines, N., Clavien, P.-A., Marino, S., Seifert, B. and Jaeger, D. (2008), Cancer testis antigen expression in gastrointestinal stromal tumors: New markers for early recurrence. Int. J. Cancer, 123: 1551–1555. doi: 10.1002/ijc.23698
Publication History
- Issue published online: 28 JUL 2008
- Article first published online: 21 JUL 2008
- Manuscript Accepted: 4 APR 2008
- Manuscript Received: 14 SEP 2007
- Abstract
- Article
- References
- Cited By
- cancer testis antigen;
- gastrointestinal stromal tumor;
- prognosis
Cancer testis antigens (CTAs) are expressed in a variety of malignant tumors but not in any normal adult tissues except germ cells and occasionally placenta. Because of this tumor-associated pattern of expression, CTAs are regarded as potential vaccine targets. The expression of CTAs in gastrointestinal stromal tumors (GIST) has not been analyzed systematically previously. The present study was performed to analyze the expression of CTA in GIST and to determine if CTA expression correlates with prognosis. Thirty-five GIST patients were retrospectively analyzed for their expression of CTAs by immunohistochemistry using the followingmonoclonal antibodies (mAb/antigen): MA454/MAGE-A1, M3H67/MAGE-A3, 57B/MAGE-A4, CT7-33/MAGE-C1 and E978/NY-ESO-1. Fourteen tumors (40%) expressed 1 or more of the 5 CTAs tested. Fourteen percent (n = 5/35) were positive for MAGE-A1, MAGE-A3 or MAGE-A4, respectively. Twenty-six percent (n = 9/35) stained positive for MAGE-C1 and 20% (n = 7/35) for NY-ESO-1. A highly significant correlation between CTA expression and tumor recurrence risk was observed (71% vs. 29%; p = 0.027). In our study population, the high-risk GIST expressed CTAs more frequently than low-risk GIST (p = 0.012). High-risk GISTs which stained positive for at least 1 CTA, recurred in 100% (n = 25) of the cases. This is the first study analyzing CTA expression in GIST and its prognostic value for recurrence. The CTA staining could add information to the individual patient prognosis and represent an interesting target for future treatment strategies. © 2008 Wiley-Liss, Inc.
Cancer testis antigens (CTAs) are expressed in a wide variety of malignant neoplasms, but in normal adult tissues CTA expression is restricted predominantly to germ cells of the adult testis and placenta.1–4 To date, more than 80 CTAs or CTA families have been identified and their number remain growing. Several monoclonal antibodies (mAbs) for the in situ detection of CTAs have been developed recently.4 Originally, CTAs were primarily identified based on their ability to elicit autologous T-cell and/or serological responses. Other CTAs were identified by methods such as database mining. Based on their tumor-restricted expression pattern, CTAs are regarded as valuable targets for cancer immunotherapy.5 Additionally, analysis of CTA expression may also be of value for the surgical pathologist helping to discriminate malignant lesions from benign neoplasms. The prognostic significance of CTA expression in many tumors remains unknown.
Diagnosis of gastrointestinal stromal tumors (GIST) is made on the immunohistochemical detection of the KIT receptor protein (CD117 antigen).6 Mutational analysis of the KIT and PDGF receptor α genes is used in KIT-negative tumors. Recurrence risk estimation after resection of a primary GIST remains challenging and is based on a consensus approach including the parameters tumor size and mitotic activity of the tumor.7 Recently, a new classification which includes tumor localization was proposed.8 The tumor localization plays an important role in relapse risk estimation.9 Additional information about CTA expression might be useful to complement prognostic factors.
Our study was performed to evaluate the expression of CTAs in a series of GISTs and its impact on prognosis.
Material and methods
Our study was done in compliance with local legal and ethical regulations. All tissue samples were retrieved from the archives of the Department of Pathology at the University Hospital of Zurich. All specimens were from standard formalin-fixed paraffin-embedded tissue blocks. Hematoxylin and eosin-stained sections were reviewed independently by S.M. and A.J. to verify the diagnosis and assess the presence of representative tissue. Morphological and histological parameters such as tumor size, number of mitoses and the presence of necrotic tissue were recorded. Only tissue specimens with unequivocal diagnosis of GIST and immunohistochemical positivity for CD117 were chosen for our study in order to reliably test the significance of CTA expression.
The cases analyzed in the present study were treated in the Department of Visceral and Transplant Surgery of the University Hospital Zurich between the years 1986 and 2006. Patient clinical follow-up data were recorded retrospectively from the medical records of the Department of Visceral and Transplantation Surgery of the University Hospital of Zurich and from the records of thepatients' family physicians. The duration between the initial operation and the first recurrence, the initial tumor site and the localization of the recurrence were analyzed. Patients with initial metastatic disease were excluded from the study. All patients were initially operated with a curative intention. The risk for recurrence was classified according to the Fletcher criteria.7 Thirty-five patients [22 males (63%), 13 females (37%)] with a mean age of 53.3 ± 19.2 years (range 12–85 years) and a mean follow-up of 59.6 ± 13.4 months (range 1–258 months) were included. Tumor primary site was stomach in 22 cases (60%), small bowel in 11 patients (31%), and in one case each colon, mesenterium and adrenal gland (9%). The patients after disease relapse received treatment with Imatinib mesylate (Gleevec®, Novartis, Switzerland).10 The impact of CTA expression on the mortality was not investigated due to only few and non-GIST related deaths during the study period (n = 5/35, 14%).
All primary tumors were analyzed for their expression of CTAs by immunohistochemistry with mAbs specific for the following antigens (mAb/antigen): MA454/MAGE-A1; M3H67/MAGE-A3; 57B/MAGE-A4, CT7-33/MAGE-C1; E978/NY-ESO-1, as described previously.11–15
After antigen retrieval, sections were incubated at 4°C overnight with MA454, 57B, CT7-33 and M3H67 mAbs. Specific binding was detected by using a biotinylated horse-antimouse secondary reagent (Vector Laboratories, Burlingame, CA) followed by an avidin–biotin complex system (ABC Elite; Vector Laboratories, Burlingame, CA). The E978 binding to NY-ESO-1 was detected with the Powervision kit (Immunovision Lab, Brisbane, CA). Diaminobenzidine tetrachloride or aminoethylcarbazole served as a chromogen. The investigators (D.P. and A.J.) were blinded to the clinical data. Testicular tissue with intact spermatogenesis was used as positive control. Immunoreactivity of tumor cells was graded as follows: focal, ∼<5% of tumor cells stained; +, 5–25%; ++, >25–50%; +++, >50–75%; ++++, >75% tumor cells positive. Immunopositivity was assigned to any grade of immunoreactivity observed in a given lesion.
The continuous and nominal data are presented as mean ± standard deviation and number with percentage, respectively. Nonparametric variables were analyzed with the χ2-test. Recurrence analysis was performed by the Kaplan–Meier survival analysis, and groups were compared by the log-rank test. A stepwise Cox-regression (forward and backward likelihood ratio) was performed to analyze independent predictors of recurrence. p-Values <0.05 were considered statistically significant.
Fourteen tumors (40%) were positive for CTAs by immunohistochemistry. The CTA expression pattern varied from focal (Fig. 1a) to homogeneous (Fig. 1b) expression. In most cases a heterogeneous expression pattern was observed. The expression rate for multiple CTAs is shown in Table I. The CTA expression pattern for each patient positive for at least 1 CTA is depicted in Table II. No patient was positive for all 5 CTAs tested. CTA expressing GIST were predominantly high risk tumors (p = 0.012). The CTA expression indicates early tumor recurrence in patients with GIST. Recurrence-free survival was significantly reduced in patients expressing CTAs (p = 0.027) over the study period (Fig. 2). Most importantly, patients developing recurrence were in 71% of cases (n = 10/14) positive for at least 1 CTA. In sharp contrast, all 10 (29%; n = 10/35) patients which were recurrence free during the observation period were negative for mAbs MA454, M3H67, 57B, CT-33 and E978 staining. Recurrence free survival for CTA negative patients at 1, 2 and 5 years was 85, 74 and 66% compared to 70, 51 and 25% for CTA positive patients. Median freedom from recurrence was 32 months in CTA positive and not reached during the study period in CTA negative patients. Accordingly, the expression of CTAs correlated with a significantly higher tumor recurrence rate (p = 0.027) over the study period (Fig. 2).
|Number of CTAs expressed
|Immunoreactive GIST
|6 (17%)
|3 (9%)
|1 (3%)
|4 (11%)
|0 (0%)
|Positive for at least 1 CTA
|14 (40%)
|Patient no.
|Total immunoreactive tumors
|5/35 (14%)
|5/35 (14%)
|5/35 (14%)
|9/35 (26%)
|7/35 (20%)
Tumor relapses occurred in 16 cases either as local recurrence (n = 12) or distant metastases (n = 4). Five patients (n = 5) died during the study period due to severe co-morbidities [cerebrovascular insult (n = 2), myocardial infarction (n = 1), other tumor (n = 2)].
The GISTs were classified according to the Fletcher criteria7 into nineteen (54%) high risk tumors, 5 (14%) intermediate risk tumors, 8 (23%) low risk tumors and 3 (9%) very low risk tumors. We confirmed the previously published data,7 indicating that tumors in the high risk group have a more aggressive course of disease and a higher recurrence rate (p = 0.001). High-risk patients showed tumor relapse in 63% (n = 12/19) of the cases. However, a 5-year recurrence free survival of 29% compared to 63% does not predict recurrence perfectly. Therefore, we analyzed if the CTA expression status of GISTs along with the established recurrence risk criteria is a useful marker to predict tumor recurrence. The statistical analysis revealed that all patients with CTA negative and non-high risk tumors (n = 10) remained free of recurrence during the whole study period (Fig. 3). This was a significantly lower recurrence rate than in those patients with a CTA positive or high-risk tumor (p = 0.002). We entered the variables localization, resection status (R0, R1, R2), positivity for at least 1 CTA, very low risk GIST, low risk GIST, intermediate risk GIST and high risk GIST into a stepwise Cox-regression. Both forward- and backward regression identified CTA expression (p = 0.03, HR = 3.3, 95% CI 1.1–9.7) and high risk (p = 0.006, HR = 8.4, 95% CI = 1.9–37.8) as independent predictors of recurrence.
The current study was performed to evaluate the expression of CTAs in GIST and its significance as prognostic marker. Despite recent advances in the diagnostic approach to GIST,6–9, 16 to estimate their risk of recurrence remains challenging. Currently, GISTs are subdivided into high risk, intermediate risk, low risk and very low risk GISTs according to the criteria published by Fletcher et al.7 Indeed, one should be aware that the biological behavior of certain cases cannot be predicted. In the past several immunohistochemical markers have been developed for GIST.17 However, none of them could be identified as an independent prognostic factor. In the present study CTA expression was found to be an independent prognostic factor in terms of tumor recurrence. Therefore, immunohistochemical analysis of CTA protein expression could add in the future important prognostic information to the established criteria for tumor malignancy. Because the medical treatment of GIST has been revolutionized by the introduction of imatinib mesylate (Gleevec, Novartis Switzerland), it is of utmost importance to accurately assess the risk of recurrence to provide the most effective treatment.18–20 At present, adjuvant treatment with imatinib mesylate for 1 year after resection of a high-risk GIST is considered by many oncologists. A recent study showed that adjuvant treatment with imatinib 400 mg daily after complete resection of a primary GIST measuring at least 3 cm and expressing KIT increased the 1-year recurrence free survival from 83% without adjuvant treatment to 97%.21
Because of their tumor-associated expression pattern, CTAs have become a prime focus for immunotherapeutic approaches against cancer in recent years. Although there is evidence of CTA expression on the mRNA level in non-neoplastic tissue,22 their protein expression is restricted to placenta and testis.22 Immunotherapy strategies focusing on CTAs target exclusively CTA positive tumor cells without affecting normal tissue.
CTAs have been used in numerous clinical trials where patients with advanced CTA positive disease were immunized with CTA derived peptides, protein, or CTA encoding DNA.23–26 Thereafter, CTA specific immune responses have been observed frequently. Some reports with clinical disease remission after successful CTA specific immune response were documented.24, 25 So far, the best studied CTAs in terms of clinical application are MAGE-3 and NY-ESO-1.23–25
Our data document that CTA expression in GIST, even with focal staining, are prognostic markers for recurrence. Consequently, the analysis of CTA expression could be of high interest for the pathologist and clinician in estimating the individual prognosis of a GIST patient.
Although most of the mAbs of the present study have been used in extensive immunohistochemical analyses, their specificity has to be regarded with caution. This is best exemplified by mAb 57B. Although mAb 57B was generated to MAGE-A3, it was later considered to be a poly-MAGE reagent and is now regarded as reactive to MAGE-A4.13, 27, 28
The problem in the determination of the fine specificity of anti-CTA reagents is caused by the high homology of the MAGE-A family members and mAb 57B might serve as an example for the specificity of other anti-CTA reagents. However, no immunoreactivity with antigens outside the CTA spectrum has been reported for any of these mAbs.
A previous study identified the expression of several CTAs in 4 soft tissue sarcoma patients, of which, 1 was a GIST patient.29 Our study for the first time systematically analyses the expression of CTAs in a series of GIST and extends previous observations.
Previous immunohistochemical studies of tumors have shown heterogeneous CTA expression in different cancers, ranging from tumors with only single positive cells to neoplasms with a generally homogeneous expression pattern. CTA are certainly not the only markers of interest for the clinician and pathologist in the diagnosis of GIST. In addition to CTAs, there are obviously other markers, i.e., KIT (CD117),6 CD 34,30 and Ki-67.31
In conclusion, our study was performed in order to determine the expression of 5 different CTAs and draw attention to the potential use of CTA analysis for the assessment of malignancy in GIST. Future prospective analyses including other CTA will show if their expression in GIST can be used as a prognostic marker. Immunotherapy strategies targeting CTA should be explored in GIST refractory to standard treatment with imatinib mesylate and sunitinib malate.
- 1Cancer/testis antigens: structural and immunobiological properties. Cancer Invest 2002; 20: 222–36., , .
- 2CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues. Int J Cancer 2002; 99: 839–45., , , , , , , , , .
- 3Identification of cancer/testis genes by database mining and mRNA expression analysis. Int J Cancer 2002; 98: 485–92., , , , , , , , , , , .
- 4Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev 2002; 188: 22–32., , , , .
- 5Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J Clin Pathol 2001; 54: 669–74., , .
- 6A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors. Gastroenterology 1998; 115: 1090–5., , , , , , , , , , .
- 7Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol 2002; 10: 81–9., , , , , , , , , , , , et al.
- 8Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol 2006; 23: 70–83., .
- 9Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer 2008; 112: 608–15., , , , , , , , , .
- 10Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO. Ann Oncol 2005; 16: 566–78., , , , , , , , , , , , et al.
- 11Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours. Br J Cancer 2000; 83: 493–7., , , , , , , , , .
- 12Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci USA 1998; 95: 6919–23., , , , , , .
- 13Expression of MAGE-antigens in normal tissues and cancer. Int J Cancer 2000; 85: 460–5., , , , , , , .
- 14Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets. Cancer Res 2002; 62: 4041–7., , , , , , , , , , , .
- 15Identification and intracellular location of MAGE-3 gene product. Cancer Res 1995; 55: 2236–9., , , , , , , , , .
- 16Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006; 130: 1466–78., .
- 17Gastrointestinal stromal tumors: differential diagnosis. Semin Diagn Pathol 2006; 23: 111–9., , , .
- 18Treatment of advanced gastrointestinal stromal tumor: a marriage of targeted therapy and surgery? Ann Surg Oncol 2007; 14: 1–2..
- 19Risk criteria and prognostic factors for predicting recurrences after resection of primary gastrointestinal stromal tumor. Ann Surg Oncol 2007; 14: 2018–27., , , , , , , , , , , , et al.
- 20Imatinib: a review of its use in the management of gastrointestinal stromal tumours. Drugs 2007; 67: 805–20., .
- 21the American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate increases recurrence free survival (RFS) in patients with completely resected localized primary gastrointestinal stromal tumor (GIST): North American Intergroup Phase III trial ACOSOG Z9001. J Clin Oncol 2007; 25(18S): 10079., , , , , , , , , and
- 22The cancer/testis genes: review, standardization, and commentary. Cancer Immun 2004; 4: 1., , .
- 23LUD 00–009: phase 1 study of intensive course immunization with NY-ESO-1 peptides in HLA-A2 positive patients with NY-ESO-1-expressing cancer. Cancer Immun 2007; 7: 16., , , , , , , , , , , , , .
- 24Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma. Int. J Cancer 2005; 117: 596–604., , , , , , , , , , , , et al.
- 25Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2: a clinical report. Eur J Cancer 2003; 39: 70–7., , , , , , , , , , , , et al.
- 26Multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of recombinant MAGE-A3 vaccine as adjuvant therapy in stage IB/II MAGE-A3-positive, completely resected, non-small cell lung cancer (NSCLC). J. Clin. Oncol 2006; 24(18S): 7019., , , , , , , , , .
- 27Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4. Int J Cancer 2000; 86: 835–41., , , , , , .
- 28Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family. Int J Cancer 2000; 86: 749–51., , , , .
- 29Antigens recognized by autologous antibodies of patients with soft tissue sarcoma. Cancer Immun 2005; 5: 4., , , , , , , .
- 30Gastrointestinal stromal tumors–value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol 1995; 19: 207–16., , .
- 31Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol 2005; 36: 828–37., , , , , , , , .


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HN-FLAM003 ArtBin
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The HSUS nearly doubled the amount of money it gives to animal shelters according to it's 2009 tax documents.
But that's not hard to do when you're going from about one half of one percent (0.5%) to four-fifths of one percent (0.8%).
Here are a few more numbers from the HSUS tax return courtesy of http://www.humanewatch.org/:
•Total revenue: $101.6 million
•Total expenses: $121.7 million
•Net assets as of December 31, 2009: $160.5 million
•Fundraising expenses: $22.3 million (23 percent of every dollar raised)
•Salaries and benefits: $35.8 million
•Total grants to other groups: $6.7 million
Here is some more info from Humane Watch:
•At long last, internal documents reveal what it takes to be one of HSUS's 11 million "members and constituents" (Hint: Just get on the group's mailing.)
•HSUS was for animal abuse registries before it was against them.
•HSUS quickly and quietly retired Humane Society International's $11 million debt in 2009. If you give "$19 a month" to HSUS, those were your donations at work.
If you're not going to http://www.humanewatch.org/ weekly you should be. I would also encourage everyone in agriculture to make a donation to this group.
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FORT WORTH (CBSDFW.COM/AP) — Allegations of pornography on a school charter bus has a North Texas company facing a lawsuit.
Parents in the Birdville school district are suing the company, alleging their children saw pornographic images on television monitors while they boarded a bus earlier this year.
The Fort Worth Star-Telegram reports the parents allege their children were emotionally harmed after they saw images from a pornographic movie that was playing on bus monitors as they boarded for a trip to a nearby ranch in April.
Officials with the bus company, Executive Coach Inc., could not immediately be reached for comment.
Birdville school district officials said the children were immediately removed from the bus. The school district is located northeast of Fort Worth.
The parents are asking for damages of more than $200,000 but not to exceed $51 million.
(©2013 CBS Local Media, a division of CBS Radio Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.)
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*Kenya Moore, arguably the most dramatic one on "Real Housewives of Atlanta," had another (of many) moments when she walked out of a charity event hosted by her co-star and enemy, Porsha Stewart.
She says the protest wasn't (surprisingly) linked to Porsha's failure to acknowledge nor failure to care, or both, about Kenya's "accomplishments." Instead it had everything to do with Porsha's timing and taste for luxury.
"Many people have confused my title and it doesn't offend me. However, in this instance, the blatant disrespect and disregard for my title and accomplishments that night did not fall to the wayside," said Kenya, who was more offended by Porsha's display of extravagance in the name of charity. "Disturbingly, the host prides herself on being a glorified gold digger and self-proclaimed 'princess,'" wrote Kenya in her Bravo blog. "You can fix a lot of things, but you cannot fix stupidity," she said.
Regardless of how anyone feels about Kenya, she does make note of an important factor. During the Hosea Feed the Hungry and Homeless Foundation, Porsha, who happens to be the founder's granddaughter, accepted some very expensive gifts from her new husband. A $4,000 Chanel handbag was a surprise gift for the event's special guest, while she had the nerve to ask people to donate money for the homeless.
"Why would anyone stand in front of a crowd under the pretense of charity wearing a $4,200 dress and receive personal gifts of a $4,000 Chanel handbag and have the audacity to ask people to donate money?" asked Kenya who said the spectacle made her "stomach turn."
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...I have taken many courses at Rensselaer Polytechnic Institute where linear algebra is key to understanding the concepts, such as Multivariable Calculus, Systems Analysis Techniques, Robotics and others. I have received stellar grades in all these classes. I have a Bachelor of Science and a Master of Engineering in Mechanical Engineering from Rensselaer Polytechnic Institute.
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Negotiation based on the Arab Initiative is the only possible solution for peace between Israel and her neighbors. Official recognition by the Arab nations is the best deal Israel is ever going to get. Why does she refuse to consider it? Does she really think she can produce something better - all by her little, lonesome self? Can't be done in isolation! Peace is a two way street.
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Clashes between IDF and Palestinians in Joseph's Tomb after Jews pray at site; none hurt (Haaretz)


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South Africa is amongst the most charming and varied nations you would go to on the planet. With its unique mixes of individuals, landscapes, culture, and history, it provides a unique and motivating moment for the tourist. 430 more words
Tags » South African Culture
Wow, I haven't written in such a long time but now, here I am and there is one thing that I am quite inspired about today. 584 more words
UCT Summer School teaches art as students burn it.
Even as students at UCT are burning artworks in protest of UCTs failure to feed, clothe, house and educate them free of charge, UCT's Irma Stern Museum is hosting a programme at the gallery named in honour of Irma Stern who died fifty years ago in 1966. 306 more words
When "Going to the Mountain" Does Not Involve S'mores
The final prompt for the Blogging Abroad Boot Camp: My new normal (aka the behaviors we required). One of the biggest PC adages in existence is that service makes you a completely different person. 910 more words
A budget Valentine's weekend
Valentine's Day is nearly upon us. Romance is called for. Not all of us have the money to spend lavishly on Valentine's Day when nearly everything is more expensive than usual. 220 more words
Where's Zuma?
Where's Wally? is a series of children's books created by the English illustrator Martin Handford. The books consist of a series of detailed double-page spread illustrations depicting dozens or more people doing a variety of amusing things at a given location. 159 more words


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This profile was last updated on // .
Is this you? Claim your profile.
Professor and Director
Hampton University
Chair of Interdisciplinary Science Center
Hampton University
www.palacio.com, 4 July 2010 [cached]
www.venustoday.com, 1 June 2010 [cached]
"We will teach them about some specific science concepts that relate to the standards they need to meet, and at the same time bring cutting-edge science into the classroom," Robinson said.
Institute for Global Environmental Strategies >> Participating Institutions By State
essea.strategies.org, 21 Jan 2008 [cached]
essea.strategies.org, 21 Jan 2008 [cached]
INSIDE BUSINESS - The Hampton Roads Business Journal
www.insidebiz.com, 9 Nov 2004 [cached]
Bruce Robinson
Maplewood Investment Advisors Inc
Glenroy Robinson
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Connie Robinson
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text:
- 18 & over
- 2 Beverage Minimum Per Person
- Non-Refundable & Non-Transferable
Purchase Tickets
Share with your friends:
Performing Artists (Click on Artist for Reviews and Previews)
Show Details
- Ticket Price: $26.00 - $115.00
- Door Time: 10:00 PM
- Show Type: Comedy
18 & over
2 Beverage Minimum Per Person
Non-Refundable & Non-Transferable
Rich Vos is an incredibly gifted comic who not only has sharp, insightful material, but he is also a master at working the crowd.
Hisability to perform in front of any audience has landed him television shows as varied as being the first white comic on Def Jam to performing on the View.
Rich was the breakout star of NBC's Last Comic Standing seasons 1 and 3, was a regular guest on Tough Crowd with Colin Quinn and wrote for Chris Rock when he hosted The Academy Awards in 2005. He also played Lenny Bruce on NBC's American Dreams and is a regular on the Opie and Anthony radioshow.
He has one of the highest rated half hour specials on comedy central and his DVD just sold over 40 copies.
Chloé Hilliard is a larger than life comedian. Well, that's because she's 6'1 and rocks a killer afro. Born in Brooklyn, NY and raised in a large Hasidic Jewish neighborhood, Chloé has spun her unique experiences into side splitting laughs. For the last ten years, Chloé has been a culture/entertainment journalist, writing for The Village Voice, Huffington Post, Vibe, The Source and more.
Tweet Feed
- 2 more days! Get your tix now! twitter.com/stevebyrnelive… Apr 27
- Looking forward to a great show this Sunday at 8PM! Buy Your Tix Now! twitter.com/victorcruzfilm… Apr 22
- RT @sammorril: NYC! I'm headlining @GothamComedy this weekend Fri and Sat. 5 Shows. gothamcomedyclub.com/event.cfm?id=4… Come out! https://t.co/2I4U4an… Apr 20
- RT @stevebyrnelive: NEW YORK CITY! I'm headlining @GothamComedy April 29/30. Would love to see ya. #NYC pic.twitter.com/EN96KnKDpO Apr 15
- RT @LaughStub: Wondering where you can see @cristela9, @sammorril, & @AriShaffir this month? @GothamComedy! Get tickets here >> https://t.c… Apr 14


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Written on: 30/03/2014 by ludmula (1 review written)
Comfortable tops, soft material, perfect shipping!Wonderful to wear when the weather is warm!
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I am getting Ink System Failure 0xc05d1281
. Help! Will not print.
As per subject question, I am getting this error code. When I send a print job, the printer grunts through a process, then ends up with this, "Ink System Failure," prompt in the AIO screen. I love my PSC. The thing about printers (actually a good thing), but I really love mine......is that to bring it in for repair, I could probably replace it for the same cost. But, I love my printer. Any ideas on how I can fix this. I will say that the printer has gone through one phase of "intermitttent problem." I had an episode of the prompt......then, later it printed on a different day. It is rumored there is a jam perhaps, but I have gone through those motions. Experts: If you are familiar with this specific error code 0xc05d1281, PLEASE HELP. Thank you for your time.
Re: I am getting Ink System Failure 0xc05d1281
. Help! Will not print.
Please read this post then provide some details.
What printer model?
Bob Headrick, HP Expert
I am not an employee of HP, I am a volunteer posting here on my own time.
If your problem is solved please click the "Accept as Solution" button ------------V
If my answer was helpful please click the "Thumbs Up" to say "Thank You"--V
Re: I am getting Ink System Failure 0xc05d1281
. Help! Will not print.
Hi, Thank you for your response!
I have a wonderful Photosmart C5180 All in One PSC.
Thank you.
Re: I am getting Ink System Failure 0xc05d1281
. Help! Will not print.
Maybe instead of saying it "grunts," it more like "clicks" through a process when it is trying to print before giving me that darn "Ink System Failure," prompt on the printer screen. By the way, all print cartridges have ink, if that matters.
Re: I am getting Ink System Failure 0xc05d1281
[ Edited ]
. Help! Will not print.
04-26-2011 11:25 AM - last edited on 04-18-2016 12:49 PM by OscarFuentes
Try following this document
If I have resolved your issue, feel free to provide Kudos and make sure you mark this thread as solution provided.
- Using HP Diagnostic Tools for HP Printers in Windows
- Printer Problems after Upgrading to Windows 10
- Print Jobs Stuck in Print Queue (Windows)
- Resolving 'Problem with Printhead,' 'Printer Failure,' 'Ink System Failure,' or a '0x...' or a 'C2...' Error
- 'Offline' Printer Status Message Displays (Windows 10)


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Shire x Haflinger/QH. This flashy black and white mare is 14.2 h. Nice riding or driving prospect. $3000 or best offer. She started under saddle this…$3,000
Tiara is a 9 year old mare. She is a beautifully soft mover and her 16.1h muscular frame and mahogany bay color will make you stand out every time. �$1,650
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She has had no injuries, has not been lame or sick. She is straight legged and good footed. She was born and raised here on our ranch. She has been exposed…$1,200
Not only is Star beautiful and exceptionally well trained; his personality makes him one of the best family horses weâ��ve ever had on the ranch because…$1,000
He is a 16.3h Irish Sport Horse gelding which has been produced and trained. He has show jumping experience in the 1.20m jumpers on the local and AA circuit…$1,400
Dodson's Heart of Fire is a 34" AMHR sorrel gelding. "Gunner" is a 4yr old refined gelding with small head/ears and well balanced with sweet disposition…$2,000
Coys Image (Gentry) is a coming 7 year old mare. She's been shown locally and at open shows in western pleasure. Started on trail and horsemanship. Has…$6,000


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The Terra HD is a friendly and portable Linux netbook with all the custom options you want. It even fits an internal 3G cellular modem for mobile broadband on the go.
"Celeste seemed surprised by how light it was, so I asked to hold it. When she handed it to me, my hands went UP! Theoretically, it's 2.9 pounds. It felt more like -5oz. And yes, that's with the 6-cell battery, not with the little 3-cell."
-- Mackenzie Morgan at Ubuntu Linux Tips & Tricks (Read her later review too.)


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Weather News
Rain lashes the Pilbara as Peta moves inlandGian De Poloni, Thursday January 24, 2013 - 13:08 EDT
Heavy rain from ex-tropical Cyclone Peta has caused flooding in some areas of the Pilbara.
Forecasters say the category one system hit the coast, east of Point Samson about 35 kilometres east of Karratha, yesterday afternoon.
Flooding was reported in Port Hedland, which received more than 100 millimetres of rain on Tuesday night and 34 millimetres in the last 24 hours.
Mount Florence Station, about 150 kilometres north of Tom Price, recorded 212 millimetres of rain overnight, while Roebourne airport received more than 80 millimetres.
The system is now a tropical low moving across inland areas and will move slowly westward as it weakens.
A cyclone watch has been cancelled, however, a severe weather warning is in place for most parts of the Pilbara today.
Thunderstorms and heavy rain are expected which may lead to flash flooding.
Debbie was at the local caravan park in Point Samson when the cyclone hit.
"It just bucketed down endlessly, it just didn't stop, it was just coming down," she said.
"All the residents did a strap down of their caravans and they all went and communed inside the rec centre."
Tony Richardson from Mount Florence Station says it has not stopped raining since yesterday afternoon.
"We've got a creek that would be the highest it's been in 10 or 11 years," he said.
"It came right up to the veranda.
"We were watching it as it was coming down the coast and we thought it was going to continue down the coast.
"We expected a storm or two but we didn't think it would come this way, no."
Meanwhile, four Rio Tinto workers were winched to safety this morning after the vehicle they were travelling in became bogged in the Pilbara.
The four employees are believed to be contracted under the Calibre Group.
They were near the Ti Tree Rail camp in the Fortescue Valley, about 75 kilometres south of Tom Price, where they became bogged on a bush track near a flooded river bed last night.
The group was flown by helicopter to Newman Hospital this morning.
A 160 kilometre stretch of the North West Coastal Highway remains closed between Roebourne and the Great Northern Highway turn-off, 40 kilometres east of Port Hedland.
The Dampier port is expected to re-open today while Port Hedland's port opened yesterday afternoon.
More breaking news
ABC News
Sydney Morning Herald
National Nine News
News Limited
Weather News
More than 90% of Australia to get rain
This Mother's Day weekend will see Mother Nature spread totals of at least 20mm to half of Australia, along with some damaging winds.
Hand-feeding sheep ends for western Queensland family, but drought and wild dog pressures remain
"I wouldn't say the drought is over ...
El Nino ushers in Queensland's quietest cyclone season for 45 years
Three named cyclones, none of which came within cooee of the coast �?? that's how will be remembered.


text:
Learn how to make a short film from beginning to end in our Film: Script to Screen program.
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KCTCS has a duty to adhere to high ethical standards and principles. All members of the KCTCS community are expected to report potential legal, procedural, and ethical violations.
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The KCTCS Intranet. Bringing content, collaboration and HR PeopleSoft functionality together, the Upgraded Intranet is here.


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Lyrics Depot is your source of lyrics to I KNOW IT'S GONNA HAPPEN SOMEDAY by Morrissey. Please check back for more Morrissey lyrics.
I KNOW IT'S GONNA HAPPEN SOMEDAY Lyrics
Artist: Morrissey
Album: Your Arsenal
My love, wherever you are
Whatever you are
Don't lose faith
I know it's gonna happen someday
To you
Please wait ...
Please wait ...
Oh ...
Wait ...
Don't lose faith
You say that the day just never arrives
And it's never seemed so far away
Still, I know it's gonna happen someday
To you
Please wait ...
Don't lose faith
i love this song
Morrissey Lyrics
Morrissey Your Arsenal Lyrics
More Morrissey Music Lyrics:
Morrissey - I'm Not Sorry Lyrics
Morrissey - Let Me Kiss You Lyrics
Morrissey - LUCKY LISP Lyrics
Morrissey - MICHAEL'S BONES Lyrics
Morrissey - On The Streets I Ran Lyrics
Morrissey - SUCH A LITTLE THING MAKES SUCH A BIG DIFFERENCE Lyrics
Morrissey - There Is A Light That Never Goes Out Lyrics
Morrissey - Will Never Marry Lyrics


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MTV Is Rebooting Unplugged, Making It Harder for You to Complain That MTV Doesn't Do Music Anymore
Sean Atkins plans to "put the 'M' back in MTV."By Jackson McHenry
Sean Atkins plans to "put the 'M' back in MTV."By Jackson McHenry
"That's like saying the Titanic hit so-not-a-big iceberg."By Emma Barrie
Initial reports are calling it an apparent suicide.By Sean Fitz-Gerald
"There seem to be a lot of black artists making very good videos that I'm surprised aren't being used on MTV."By Ira Madison III
The show was filming in Argentina.By Greg Cwik
A new reality show brings visibility to the genderqueer community.By Katherine Bernard
Daria's willingness for real talk on race, gender, and identity feels as crucial today as ever.By Phoebe Robinson
The GDH flat iron won't let you mess up no matter how hard you try.By Ashley Weatherford
This is going to be MTV's attempt at scripted fantasy fare.By Sean Fitz-Gerald
Here we go.By Sean Fitz-Gerald
The journalist discusses his new documentary.By E. Alex Jung
She announced the news on her Instagram with a very green post.By Sean Fitz-Gerald
"What does it mean to be young and white?"By Dee Lockett
"It was one big bloodbath of actors."By Josef Adalian
Lots of short jokes.By Sean Fitz-Gerald
For MTV.By Sean Fitz-Gerald
In the Hollywood version of Steubenville, the girl comes back from the grave and into her attackers' Gchats.By Allison P. Davis
Watch out for snakes, please.By Sean Fitz-Gerald
In April 2015.By Sean Fitz-Gerald
After a years-long battle with cancer.By Marcus Jones


text:
Pregnant was something of a metaphor when it first started being used in relation to a baby. Its earlier meaning (which is still in use) was 'full of meaning, highly significant', and the word pregnant began being used as a synonym for the more self-explanatory term with child. There are plenty of historical synonyms for […]
Expectant parents don't generally have a lot of spare time for idly perusing the dictionary, but if they did, they would find that the vocabulary of the event they joyfully anticipate has undergone significant changes over the centuries. Consider, for instance, the verb to deliver. In contemporary use, the mother is often the subject of […]
#Quote of the Week pic.twitter.com/hUYfZn4Ada
Quiz: how well do you know sweets around the world? oxford.ly/1LHc7ba pic.twitter.com/LdRKNna4mN
Discover the lost linguistic world of Polari: oxford.ly/1APxu63 pic.twitter.com/JjxMohneJF
Word of the Day: clade - a group of organisms with a common ancestor…... ow.ly/8JXZPL
On #InternationalJazzDay, find out how jazz musicians ended up with all those nicknames: oxford.ly/1DYSFWA pic.twitter.com/61O3N3mGjF


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Neither team had played against the other before, but they had something in common. Every player's jersey was emblazoned with the number 22 and "JACKSON."
After a frenzied warmup, the black and white jerseys separated to either side of the rink, and each player raised a stick in the air.
The room was abruptly silent as more than 100 friends, family and teammates at the Chaska Community Center late Friday night paid tribute to Andrew Jackson, the 18-year-old college freshman from Chanhassen who died last week when a Purdue University hockey club team van rolled over near Wingate, Ind.
Jackson's sister, Nicole, 21, traded her weariness from Friday afternoon's funeral for the excitement on the ice. She said there was no better way than hockey to celebrate her brother's life.
"This was Andrew," she said. "This was how he measured his life."
Only hours after his death, Jackson's friends, scattered across several states, formed a Facebook group called "RIP Andrew Jackson."
Purdue goalie Grant Burdeau, of Munster, Ind., said there was soon a suggestion that everyone get together for a game, and the word spread.
A team of Purdue players, clad in white, faced off against an extemporaneous team of Jackson's high school friends and former youth hockey teammates.
Each team had its own memories of Jackson. Friends from high school were playing for a Jackson who had bounced back from a cancer diagnosis his freshman year at Academy of Holy Angels in Richfield.
Friends from Indiana had watched a vibrant young player join their ranks, instantly clicking with his defensive partner, said Purdue's team captain, Ted Ward, of Glenview, Ill.
"It might be selfish," he said. "I want to say he'd be rooting for us."
The Purdue team won 7-4, but the cheers were all for Jackson.
From the stands, his mother, Hope, had tears in her eyes as she watched dozens of players wearing her son's number shake hands at game's end.
Courtney Blanchard • 612-673-4921
StarTribune.com welcomes and encourages readers to comment and engage in substantive, mutually respectful exchanges over news topics. Commenters must follow our Terms of Use.
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Comments will be reviewed before being published.
- Poll shows Minnesotans glum about future, campaign choices
- In Twin Cities, as demand rises, so do entry-level homes
- Counterpoint: Pension fixes are already on the table
- Review: The Who have been better, you bet
- Souhan: Twins' path to the cellar is paved with bad trades
- Obama is sharp-tongued at his final White House Correspondents' Dinner


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Sales Account Executive
Stuart, FL
ROBIN ROSE 561-***-**** EXPERIENCE Executive Recruiter, Ascendo Resources 2014-Present West Palm Beach, FL Full cycle recruiting to attract, screen, select and onboard qualified and suitable personnel to fill job openings. Attracting top talent to... -
Apr 23
Web Developer Services
Stuart, FL
Resume of John Flurkey Stuart, FL ***** email@example.com 772-***- **** Professional Summary ASP. Net Developer in areas of E-Commerce, County Government and Medical Devices Motivated by being an effective problem solver and communicator Work... -
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Experienced software engineer
Vero Beach, FL
Experienced Software Professional Email LinkedIn in Location Vero Beach, Availability Immediate Experienced software professional with years of industry experience with solid background in multiple of software development process. Innovative... -
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Vero Beach, FL
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Nurse Practitioner Care
Port Saint Lucie, FL
*** ** ******** **., **** Saint Lucie, FL ***** Lindsay Serey Objective Family Nurse Practitioner student at Florida Atlantic University graduating in May 2016 seeking a career where I can become a valuable member of the healthcare team Clinical... -
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Miriam Owens **** ** ******** ******, **** Saint Lucie, FL 34953 firstname.lastname@example.com 772 *** **** PROFESSIONAL NURSING EXPERIENCE: Saint Lucie Medical Center, Port Saint Lucie, FL Jan 2009-present Registered Nurse – adult intensive care unit... -
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Stuart, FL
Randal I. Vanden Bosch **** ** ******* **** • Stuart, Florida 34997 Home: 772.***.**** • Cell: 407.***.**** Email: email@example.com Healthcare Operations Management, Revenue Cycle Management … Support the mission and goals and set a high... -
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Kimber Dannelle Dykes *** ** ** ******* ** Port St Lucie, Fl 34986 cell: (772) ***-**** firstname.lastname@example.com OBJECTIVE I am looking for a position at a stable, and growing company where I can use the skills I have learned over the years, and... -
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Tags » NYC BLog
NYC Dating Diaries
I'm just a typical girl living in New York City, here to share the untold truths that Sex and the City lied about (like living in a huge apartment while just being a writer and having multiple straight boyfriend's…SOMEONE PLEASE TELL ME WHERE THE STRAIGHT MEN ARE BESIDES ASKING FOR NUDES ON TINDER?) 81 more words
Museum of the Moving Image, Astoria
This weekend I visited the Museum of the Moving Image in Astoria and had a great time. If you're interested in any aspect of cinema, television or even cartoons, this is a great place! 438 more words
7 deadly sins | Gluttony
Gluttony (n.) Habitual greed or excess in eating.
My Experience with Gluttony
As someone with many dietary restrictions, being gluttonous is masochistic. If I overindulge in anything fried, creamy, spicy, cheesy, or well fatty in general, that's pretty much the end of my day. 100 more words
New Subway Trains for NYC
I am all for change, in some cases, I even welcome it. But when it comes to the NYC subway system, one needs to tread carefully. 850 more words
Snowboarding in NYC
It's times like these that I wish I had learned to snowboard. I tried once, but let's just say I was not very good. There is something very humbling about watching five year old children zoom past you with little fear and exceptional balance. 73 more words
Snow Storm Jonas Hits NYC
Unless you have been hiding under a rock, or living on the West Coast, you have most likely heard about Winter Storm Jonas which has been taking out much of the East Coast. 132 more words


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is Sunday, May 8.Find a gift she'll love.
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Our VP of creative projects shares what she's into.
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Stance 'Star Wars® - Chewie' Socks (Big Kid)
Under Armour 'Blitzing 2.0' Stretch Fit Baseball Cap


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04.29.2016 | 21 Nisan, 5776
Hamas: 'There will be an explosion' unless Israel lifts Gaza blockade
Two Palestinian teens attempt to stab IDF soldier at West Bank checkpoint
Palestinians clash with IDF forces as Jewish worshipers visit Joseph's Tomb
Exclusive: Israeli envoy slams Austria's hosting of Palestinian hijacker terrorist
NYT: Israel denies waiting for Obama successor to strike defense aid deal
Bikini blunder?: Bar Refaeli swimsuit collection accused of copying $11 eBay design
Analysis: Are US, Israel winning or losing newest cyber battles
Police suspect Ma'aleh Adumim man shot and killed terminally ill wife, before killing self
Gal-On endorses Berko to head key Knesset panel
Mimouna all night long
Katz: We can't count on US at UN
Music maestro Zubin Mehta remains young at heart
ISRAELI OPERA Gounod: Romeo and Juliet TA Opera House, April 18
Dining: A roadside attraction
Dining: Illuminating
J'lem wraps up first place and home court in postseason
Rajkovic suspended following Sakhnin brawl
Tensions run amok as Mac TA, Sakhnin brawl in rematch
Sinai Says: New horizons open up for Casspi following breakthrough season
Your investments: Omer and building wealth
COLUMN ONE: Defeating Hamas in America
Israel's economy: Reasons to be cheerful – and some for concern
MIDDLE ISRAEL: Should we visit Auschwitz?
Italy nabs four suspected in ISIS plot to attack Israeli embassy, Vatican
Five years on, Jordan grapples with Syrian refugee crisis
Explosion in Turkey's Bursa caused by female suicide bomber
Abbas surprisingly dismisses governor of Nablus after alleged criticism on Facebook
Analysis: The limits of the Iran-Russia alliance
Report: Iran looks to deploy Hamas in the battle to liberate Mosul from ISIS
South African president in Iran to develop ties
US to buy heavy water from Iran's nuclear program in $8.6m deal
VIDEO: ISIS forces withdraw from strategic town under Assad's protection
Boston-area men charged in ISIS-inspired beheading plot against police
ISIS ruins part of the ancient Assyrian city wall near Mosul
UK Jewish backers of Muslim NUS head slam 'Islamophobic witch hunt'
Vandals deface Orthodox New York neighborhood with swastikas
UK's Labor suspends ex-London mayor after 'Hitler supported Zionism' remarks
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שִיר הַחֵירוּת
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Diplomacy & Politics
12/06/2012 17:40
Ronald Reagan on screens 370.
(photo credit:REUTERS)
"NEXT TUESDAY is Election Day," then-Republican presidential candidate Ronald
Reagan famously said in his final debate with then-president Jimmy Carter on
October 28, 1980."Next Tuesday all of you will go to the polls and stand
there in the polling place and make a decision. I think when you make that
decision it might be well if you ask yourself 'Are you better off than you were
four years ago? Is it easier for you to go and buy things in the stores than it
was four years ago? Is there more or less unemployment in the country than there
was four years ago? Is America as respected throughout the world as it was?'"
Reagan continued, "If you answer all those questions yes, why then I think your
choice is very obvious as to who you will vote for. If you don't agree, if you
don't think that this course that we have been on for the last four years is
what you would like to see us follow for the next four, then I could suggest
another choice that you have."And with those few sentences Reagan gave
birth to a campaign slogan that has been heard ever since by incumbents and
challengers running for office in every nook and cranny around the world. You
can hear it in stump speeches given by those running for prime minister of New
Zealand, chancellor of Germany, president of the United States.
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Being an international model was it difficult to see your body change when you became pregnant? How have you dealt with your post-pregnancy body? Do you have any tips for getting back into shape after giving birth?To be honest, I completely embraced what was happening to my body during my pregnancy... It was post pregnancy where I had to battle the self-confidence bug. It takes time to get back into shape (especially when you've just had a baby and technically have no free time). I travelled to England six weeks after I had Luke so I had to be very disciplined with my eating plan as I didn't have too much time to myself for gym. Best thing though is to eat well, gym when you can, sleep when you can and try not to put too much pressure on yourself.How has having children changed your life and career?Life is crazy busy! From a work perspective, certain things changed. I don't quite have as much time to work as hard or as much as I used to but I feel very well balanced. We travel every year to England for Neil's cricket so life is pretty nonstop but I love it!Is it difficult splitting your life between South Africa and London? Do you see yourself coming back to South Africa permanently one day?It can be pretty tough going backwards and forwards to England every year, especially as the kiddies start getting older. Luke will be starting "big school" next year which complicates issues somewhat so from next year we have to assess school terms and holidays and work it out from there. We'll be back permanently soon, although I get very itchy feet - the travel bug always bites! After spending so many years in the modelling industry, what would you say to your daughter becoming a model? Would you support her or are you wary of the industry?I've been asked this question many times actually and if Riley came up to me before she was 16, I would say no... Thereafter, I would allow her the opportunity to try and then decide for herself. I would be very present though as my mom was with me! What is it like to be in the same industry as your sister? Have you two worked together before?Oh, yes. Tracy and I have worked together quite a few times and they were always really fun days! Funny enough, the closest thing to sibling rivalry we have was borrowing each other's clothes without asking... We fully support one another and have never really felt like we were in "competition" with each other. I'm proud of all my family, one in a million! Tell us about your career at the moment? Where can we look out for you/ expect to see you in the near future?It's winter at home and I'm in England so I take this time of the year off, so to speak. Summer and season are on their way and I'll happily get back into the swing of things and enjoy spending time in Cape Town; I always do quite a lot of modelling then... I have the Brut campaign on TV right now I believe, so keep a look out for it! I am also involved in an antibullying campaign and do work with Children's Charity Foundation among others.What advice would you give to young girls hoping to start a modelling career?My advice to young girls is first and most importantly, only do what lies within your comfort zone. Be yourself and try not to take it personally (when castings don't go your way). Remember that most of the time it doesn't happen overnight! Finish school! The glitz and glamour you see is a very small margin of the reality of this job. It's hard work. The experiences can be incredibly rewarding so stick it out, as long as you're happy though of course.If you could write a letter to yourself when you were younger, what would you say?Dear Kerry, Listen to your mother!Kind regards, SelfFollow Kerry on Twitter.Follow Women24 on Twitter and like us on Facebook.
Blogger Anja van der Spuy gives us eight tips and tricks to finding (and securing) the job you've always wanted.
Great advice to get you out of bed in the morning.
Read Women24's Comments Policy
24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.
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After having lost its deal with Google, Twitter is now at risk of losing the chance to re-up with Bing. Both Bing and Twitter have a lot at stake with this partnership, but the companies have been unable to agree on contract terms.
The Difficulty with the Deal
Bing and Twitter are just a few months away from the expiration of their data feed partnership, which powers the niche Bing Social search. However, according to several insider sources quoted by All Things Digital, Bing and Twitter may be having trouble settling on workable contract terms.
According to All Things Digital, "The pair [Bing & Twitter] is still far apart on a number of issues, including the price and term of the data licensing, the way the tweets and advertising linked to it will be presented on Bing, the cut of that advertising, and even how much traffic Bing pushes back to Twitter."
Bing, who has paid Twitter approximately $15 million (U.S.) annually, is now being asked for twice that amount. This isn't the big problem, though, according to insider sources. The real issues stem from the UI control, advertisement cut, and backlinks.
What's at Stake
On Twitter's side, the big concern is income. Having failed to launch a highly successful ad mechanism on their site (they are still working on a self-service program, slated for later this year), Twitter is in need of strong revenue sources.
Twitter's failure to re-up their partnership with Google, which began in October 2009 and expired July 2 and resulted in Google shuttering Google Realtime search, meant a loss of tens of millions of dollars. Certainly, $30 million annually isn't negligible.
Bing has a lot to gain as well. The introduction of Facebook-prompted results in the Bing SERP was the original cause of the social search phenomena. If Bing can get a deal with Twitter while Google stands on its own, Bing will have a monopoly on the top social networks of today.
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Bcbg Max Azria Perfume
By Max Azria for Women
Bcbg Max Azria Perfume by Max Azria, Bcbg max azria, the first fragrance under the name of the fashion house, was launched in 2011 . Created by givaudan perfumer stephen nilsen, the fragrance defines the fruity – flowery spirit of womanhood, with a powdery shroud. The top notes dominate the lively nature of women with wild strawberry and cherry. The floral heart of jasmine, rose, lily of the valley and violet, manifests tenderness. While the fougère base of musk, sandalwood and orrisroot hint at ... Read More ... Read More the secretive feature. The exquisite flacon with the modified logo of the brand's butterflies as flower petals, arouse your desire for this eau de toilette. All products are original, authentic name brands. We do not sell knockoffs or imitations.
- O D'azur
- O De L'orangerie
- O De Lancome
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- Odin 01 Sunda
- Odin 04 Petrana
- Odin 06 Amanu
- Odin 07 Tanoke
- Odin 08 Seylon
- Odin 09 Pasala
- Odin 10 Roam
- Odin 11 Semma
- Odin 2 Owari
- Odin 3 Century
- Odori Iris
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- Or Des Indes
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- Orange Blossom The Healing Garden
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- Organza
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- Oriental Lounge
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- Original Santal
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- Oro Paulina Rubio
- Os Signature
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- Oscar Bamboo
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- Otto Kern
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- Oud For Love
- Oud Robert Piguet
- Oud Save The King
- Oud Save The Queen
- Oui
- Our Moment
- Own It
- Oxygene
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- Ozbek
3.4 oz Eau De Parfum Spray
Item #482673
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$ 22.49Add To Cart
1.7 oz Eau De Parfum Spray
Item #492891
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Hurry! Only 3 in stock
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This product has 5 Out of Stock items |
0.05 oz Vial (sample)
Item #516936
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3.4 oz Eau De Parfum Spray (Tester)
Item #491885
3.4 oz Eau De Parfum Spray (unboxed)
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Gift Set - 1.7 oz Eau De Parfum Spray + .25 oz Mini EDP Spray + 3 oz Body Lotion
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About Max Azria
History and background of Max Azria. Max Azria was born in Tunisia in 1948. He moved to Paris when he was 13 years old, to study acting and was educated there. BCBG stands for Bon Chic Bon Genre, which means "good style good attitude" in French. It is the name which Max Azria uses as the name of his company. The name and logo were designed by Max's wife Lubova. Read more about Max Azria
More Max Azria fragrancesfor Women: Bon Chic , Bon Genre , Bcb Girls Star , Bcb Girls Sexy , Bcb Girls Nature , more
See all Max Azria products
Customer Comments
I was so happy to find the fragance at this site as it is not available in the stores!
D. Atkins (Penn Laird, VA)
REVIEW SNAPSHOT®by PowerReviews
- Great smell (15)
- Clean & fresh (12)
- Not overpowering (12)
- Great value (11)
- Draws compliments (9)
Best Uses
- Anytime (13)
- Daily use (8)
- Special occasions (6)
- Evening (4)
- Signature fragrance (3)
- Reviewer Profile:
- Classic style (7), Natural style (5)
- Fragrance Type:
- Floral (12), Citrus/fruity (8), Fresh/aquatic (4), Woody/earthy (3)
Most Liked Positive Review
Absolutely Fabulous!
I purchased this perfume for my "Bonus Daughter". I had given her a sample awhile ago, and she told me she loved it so much and wasn't able to find it...Read complete review
I purchased this perfume for my "Bonus Daughter". I had given her a sample awhile ago, and she told me she loved it so much and wasn't able to find it anywhere in the area she lives. She was savoring it and using very sparingly. I went on to Fragrane X and it was temporarily unavailable. I signed to be notified when available and sure enough a couple weeks later I received an email stating it was in stock, but only 6 were available. I immediately ordered it and she came to visit us a day after it arrived. I surprised her with it, she was so excited. And, after she went home that weekend, she emailed me and told me she absolutely Loves the BCBG and gets tons of compliments and it makes her feel so Special! She uses it daily and when she goes out and it makes her Happy!
Most Liked Negative Review
Sweet scent for teenage girl!
A little too much sweet for my taste. But if you like cherries and very sweet fragrances I think you'll like that.
A little too much sweet for my taste. But if you like cherries and very sweet fragrances I think you'll like that.
Reviewed by 17 customers
Displaying reviews 1-5
Previous | Next »
- Draws Compliments
- Great Smell
- Great Value
Best Uses
- Anytime
Comments about Bcbg Max Azria By Max Azria:
I use BcBG perfume in the morning before work. I get complaintsome on the fragrance all the time. I bought two and got a really good price.
- Fragrance Type:
- Floral
- Clean & Fresh
- Draws Compliments
- Great Smell
- Great Value
- Long-Lasting
- Not Overpowering
Best Uses
- Anytime
- Daily Use
Comments about Bcbg Max Azria By Max Azria:
great fragrance, beautiful bottle, fast shipping. My daughter was delighted.
- Fragrance Type:
- Citrus/Fruity, Fresh/Aquatic
- Great Value
- Long-Lasting
- Sensual
- Sexy
- Overpowering
Best Uses
- Evening Use
- Special Occasions
Comments about Bcbg Max Azria By Max Azria:
A little too much sweet for my taste. But if you like cherries and very sweet fragrances I think you'll like that.
- Fragrance Type:
- Citrus/Fruity, Floral, Oriental/Spicy, Powdery
- Clean & Fresh
- Great Smell
- Light Fragrance
- Not Overpowering
Best Uses
- Anytime
Comments about Bcbg Max Azria By Max Azria:
Use it everyday!
- Fragrance Type:
- Floral
- Great Smell
- Great Value
- Long-Lasting
- My Gift To My Girlfriend
- Not Overpowering
- Sensual
- Sexy
Best Uses
- Anytime
Comments about Bcbg Max Azria By Max Azria:
Something different and special for my girlfriend. Makes her individual and we love BCBG Max Azria, not well known in England. Recommended.
- Fragrance Type:
- Floral
Displaying reviews 1-5
Previous | Next »


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The Financial Rights Legal Centre says its Insurance Law Servi...The Financial Rights Legal Centre says its Insurance Law Service will have to close in July next year due to a lack of government funding. The warning follows a 16% increase in demand for the free consumer advice service since March. Centre ... InsuranceNews.com.au, 1 day ago
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June 11, 2009
Mary Talent throws me our Commercial Dispatch each afternoon as I sit swinging in my great-grandaddy''s old white swing on the front porch. We exchange, "Hey, how''s it going, how are ya?''
Today''s paper, "Dispatch launches new Starkville paper." Wow!
We welcome y''all into your "sister city," Starkville.
Best of everything.
Carole and Frank Davis
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5. Jamie Stiehm: The way of the world, Hamilton, Jackson and Tubman NATIONAL COLUMNS


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High quality fly tying hooks are what you get with Daiichi fly tying hooks. From the smallest trout fly tying hooks to large stainless steel fly tying hooks for tarpon, Daiichi fly tying hooks won't let you down.
Fly Tying Video Guides
How to Tie a Perfection Loop Knot
How to Tie an Improved Clinch Knot
How to Attach Backing to a Fly Reel
How to Tie a Double Surgeon's Knot
How to Tie a Rapala/No-Name Loop Knot


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Services->Real Estate
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Full company description is available with the free trial.
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The company profile also contains facebook info, phone numbers, linkedin accounts, cfo contacts, and MTM REALTY, INC. email format addresses with the domain of @mtmrealty.com. MTM REALTY, INC., a Real estate company has its main office in Somerset, PA. If you sign up for our free trial you will see our firstname.lastname@example.com addresses.
Company Background:
Full company description is available with the free trial.
Similar Companies:
#1 Choice Real Estate
Want to know how to get in touch with them? Lead411 has the email addresses of #1 Choice Real Estate's top officials for the company domain @1choiceinc.com format. #1 Choice Real Estate is a Real estate company centred in Murrysville, PA and our profiles could include more contact information like cfo people, linkedin contacts, phone numbers and facebook pages. If you sign up for our free trial you will see our firstname.lastname@example.com addresses.
1260 Housing Development Corporartion
If you don't want to waste too much time looking for company information regarding 1260 Housing Development Corporartion, a Real estate company, check out their Lead411 profile. Our profiles have linkedin data, phone numbers, cfo contacts, and more. It contains helpful contact information regarding top company officials, including that of 1260 Housing Development Corporartion's CEO , and other 1260 Housing Development Corporartion email format addresses within the @columbuspm.org domain. 1260 Housing Development Corporartion is based in Philadelphia, PA. If you sign up for our free trial you will see our firstname.lastname@example.com addresses.
1st Foreclosure Prevention
1st Foreclosure Prevention, is a company that works within the Real estate. This Huntingdon Valley, PA-based business. Their profile on Lead411 presents significant contact information such as cfo contacts, phone numbers, linkedin data, and 1st Foreclosure Prevention email format addresses with the @1stforeclosureprevention.com domain as well as quality contact info regarding 1st Foreclosure Prevention's CEO . They have their head office in Huntingdon Valley, PA. If you sign up for our free trial you will see our email@example.com addresses.
Company Directory > MTM REALTY, INC.


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