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Scantily clad fun with moving images, courtesy of Arianny Celeste, Brittney Palmer and more.
A closer look at Gamora from 'Guardians of the Galaxy'. Minus the green skin (and most of her clothes).
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Comments about 'Losing a coach doesn't mean a program is doomed or must suffer'
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I would agree but one must also realize that college football is a coach's league. Without a great coach, a program won't compete for long. College coaches have to be great recruiters, develop a top-notch organization and make critical game day decisions. Hopefully, this new coach is up to the challenge. Some programs can replace a great coach with another great coach or at least a competent coach. The latter would be my bet here. Hopefully, the Aggie fans will be reasonable with their expectations...
- 4:36 p.m. Dec. 23, 2012
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I am not a fan of bringing in the asst coach unless you think the asst was the reason the head coach was succesful. I would have gone back to Utah and hired the defensive cord. This hire was a big mistake. I hope I'm wrong.
- 5:52 p.m. Dec. 23, 2012
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Andersen is the primary reason for the Aggies success. I think Wells deserves a
shot and you have to give the USU administration some trust here in the hire.
Whether this guy is the next Chris Petersen, to fit your example runnerguy50, it's hard to know. It may seem like Andersen may have been the primary reason behind the success of Utah.
- 9:45 p.m. Dec. 23, 2012
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Keep drinking that dark blue cool aid. The truth is u may well be back to square one, which is not a very nice place.
- 7:04 a.m. Dec. 28, 2012
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I think the team will do just fine next year. We have 16 starters returning and
the DL, WR, and QB coaches will be back as well. And Wells knows how to run an
efficient offense.
This is not your father's Utah State program. Increased funding, upgraded facilities, and better recruits have helped make Utah State football relevant again.
- 3:48 p.m. Dec. 28, 2012
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DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
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In ancient times the expression was "All roads lead to Rome." An impressive network of roads had been built to maintain the Roman Empire, but it eventually broke apart and failed. These days all roads lead to Tehran, the capital of Iran, the terror capitol of the world, and to its supreme leader, Ayatollah Ali Khamenei.
The attacks on Israel were ordered by Khamenei and the support for Syria's dictator Bashar Assad come from Khamenei. Perhaps inspired by the success of the al Qaeda attack on a U.S. consulate in Benghazi, Libya, on the anniversary of 9/11, Hamas-a proxy for Iran in Gaza-increased its rocket attacks on Israel.
Among the rockets raining down on Israel is a Fajr-5 that is made in Iran.
It is important to keep in mind that these rocket attacks have been made for a decade. However, following the reelection of President Obama, they increased and it is my view that the Iranians have taken his measure of the four years of his first term and concluded that he would do little to support Israel and that they could increase their efforts to create nuclear weapons with which to destroy Israel and threaten the Middle East and the world.
DEBKA File, an Israeli news agency reported on November 17th that President Obama had called Israel's Prime Minister Netanyahu to reiterate "his support for Israel's right to defend itself." In addition, he called Egyptian President Mohamed Morsi to urge him "to persuade Hamas to accept Israel's terms for a ceasefire."
The reality is that there has been no ceasefire from Hamas since it seized control of Gaza from Fatah, as the Palestinian Liberation Organization is also known. The PLO governs the West Bank, an area Israel secured as the result of an earlier war.
Israel is under fire as the direct result of Obama's actions and statements during his first term. This is what happens when sixty years of support and cooperation are abandoned in an effort to curry acceptance by Middle Eastern regimes and people.
It is useful to consider the record of wars waged against Israel since it declared its sovereignty in 1948. The announcement was followed immediately by the 1948 Arab-Israeli War that ended in July 1949. Military actions were carried out against Israel throughout the 1950s and 60s from Syria, Egypt, and Jordan. There was conflict when Israel joined Britain and France after Egypt announced its intention to occupy the Sinai Peninsula and take over the Suez Canal. The Six-Day War in June 1967 was triggered by Egypt and joined by Jordan and Syria. Israel won a decisive victory, expanding its territory to include the West Bank, the Golan Heights, and Gaza.
Another war of attrition followed from 1967 to 1970. In October 1973 Israel was attacked on its holiest day, Yom Kippur, by Egypt and Syria. From 1971 to 1982 led to an invasion of Lebanon in 1978. In 1982, another war was fought with Lebanon which had become a staging area for the Iranian proxy, Hezbollah. More conflict continued from 1987 to 2000. From 1987 through to 2005, a Palestinian uprising known as the Intifada continued. And in 2006 another war with Lebanon was triggered by the abduction of two Israeli reserve soldiers by Hezbollah.
The first Gaza war, December 2008 to January 2009, was waged against Hamas, an Iranian proxy, and now, as the result of months of rocket attacks on Israel, it has been renewed.
The Iranians are within months of achieving their long time goal of creating a nuclear arsenal. On October 19 DEBKA File reported that its intelligence sources had learned that Iran "had finished installing in Fordo the last set of advanced centrifuges for enriching uranium to 20 percent purity" which will give the ability to enhanced these stocks to the 90 percent bomb-making level.
"American experts," said DEBKA File, "now estimate that this jump would take no more than two to three weeks from the moment a go-ahead order came down from Khamenei."
Writing in the November 16 Wall Street Journal, Saul Singer said "Even the debate over sanctions and military action against Iran's nuclear program largely misses the point. The solution is for Iran's regime to fall, and the key to that isn't sanctions or even military action. It is for Western governments to star saying to Iran's leaders what they told Egypt's Hosni Mubarack, Libya's Moammar Gadhafi, ad Syria's Bashar Assad: You must go."
Singer said that "There is a reason why Iran is desperately trying-with money, personnel and weapons-to keep Assad's brutal regime afloat in Syria. What the mullahs fear more is the Arab Spring spreading to Iran."
Even former Secretary of State, Henry Kissinger, writing in a recent issue of the Washington Post, said, "The most urgent decision facing the president is how to stop Iran from pursuing a military nuclear program."
World War II began because the nations of Europe sought appeasement with the Nazi regime. They delayed preemptive action until it was too late. The U.S. and the nations of the world have followed the same path with Iran. The Obama "apology tour" to the Middle East has been a total failure and has brought the world to the brink of a war there that could spread to wherever there are nations with large Muslim populations. And Europe has large Muslim populations.
All this is happening as a U.S. government in gridlock faces a "fiscal cliff" that would require huge cuts to our defense budget at the worst possible time. A profligate Obama regime has increased the national debt to $16 trillion and large numbers of Americans are unemployed. This mirrors the 1930s in which a recession from which the nation could have recovered was so badly botched that it became the Great Depression.
The only option the U.S. and the West has is to join with Israel to destroy or significantly disable Iran's nuclear program and attack its military capabilities. The Gaza attacks on Israel are part of the Iranian effort to test and "soften up" its defenses, to engage the Israeli Defense Force in a ground war that will deplete its armed forces.
Americans and Israelis embrace life, but our enemies embrace death. They are taught from birth that dying in a holy war-a jihad-opens the gates to paradise.
We are on the brink of a Third World War intended to bring about a new Islamic caliphate, the control of the world by Islam.
© Alan Caruba, 2012
FamilySecurityMatters.org Contributing Editor Alan Caruba writes a weekly column, "Warning Signs", posted on the Internet site of The National Anxiety Center, and he blogs at http://factsnotfantasy.blogspot.com. His book, "Right Answers: Separating Fact from Fantasy", is published by Merrill Press.
Join FSM and stay informed. Get your daily Security Update delivered each day to your e-mail.
They didn't build that: White House takes credit for 'jump-starting' smart gun development
April 30, 2016 10:45 PM
Smart gun? Yet again, the White House is ready to throw money at something that doesn't work and no one wants.
The post They didn't build that: White House takes credit for 'jump-starting' smart gun development appeared first on twitchy.com.
'It's true'! NYT op-ed hails Obama's comedic talent ahead of #WHCD (and many agree)
April 30, 2016 02:32 PM
"Putin laughs at him all the time."
The post 'It's true'! NYT op-ed hails Obama's comedic talent ahead of #WHCD (and many agree) appeared first on twitchy.com.
'Very offensive roots': Clinton camp responds after backlash for 'racial slur against Native Americans'
April 30, 2016 01:33 PM
"Perhaps Hill should explain what she meant by this."
The post 'Very offensive roots': Clinton camp responds after backlash for 'racial slur against Native Americans' appeared first on twitchy.com.
Baghdad in 'state of emergency'; Obama monitoring developments from outdoor situation room ('FORE!')
April 30, 2016 12:12 PM
Got to take care of some priorities ahead of tonight's White House Correspondents Dinner?
The post Baghdad in 'state of emergency'; Obama monitoring developments from outdoor situation room ('FORE!') appeared first on twitchy.com.
Yuge 'No Labels' lift? Piers Morgan spots a 'very good running mate for Trump'
April 30, 2016 10:51 AM
Would the man who had high praise for Hillary Clinton and Barack Obama be perfect for Trump?
The post Yuge 'No Labels' lift? Piers Morgan spots a 'very good running mate for Trump' appeared first on twitchy.com.
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Prince's Sister Tyka Nelson Storms Out of Family Meeting. Why?
- 10:57 AM, Apr 29
Chris Brown and His Entourage Stop for Lunch at Chipotle Mexican Grill
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#MegaMan badges have been added to Nintendo Badge Arcade! pic.twitter.com/mNakZ3URhO— Nintendo of Europe (@NintendoEurope) May 6, 2016
#MegaMan badges have been added to Nintendo Badge Arcade! pic.twitter.com/mNakZ3URhO— Nintendo of Europe (@NintendoEurope) May 6, 2016
5月11日(水)の20:30より「カルドセプト® リボルト ダイレクト」を放送します。シリーズファンの皆様に最新情報を直接お届けします。#NintendoDirectJP https://t.co/URMW80e40Y pic.twitter.com/p89p1p2cBF— 任天堂株式会社 (@Nintendo) May 6, 2016
The Japanese Nintendo 3DS title Culdcept Revolt will be getting its own Nintendo Direct presentation. Scheduled for May 11 at 20:30 JST (13:30 CEST/7:30AM ET), the Direct will be discussing the ins and outs of the game.
Friday, boys and girls! The last day of the week is here and not a moment too soon. Time to knock this sucker out and get into the fun stuff! I hope you all have some fantastic plans ahead of you this weekend, even if it just means taking a nap and playing games. I say you earned it, damnit! See you in a few, short hours.
We've been writing about Super Meat Boy for sooooo many years. It's actually surreal for me to write that the game really is coming out on Wii U next week. While the title never did hit WiiWare, Team Meat kept a promise and brought the game to Nintendo fans.
Team Meat was also nice enough to give us an early look at the game on Wii U! Now I've played Super Meat Boy to completion years ago, but my parents have NO Idea what it is. I knew it would be a perfect game for them to check out, and Team Meat made that possible for us a week early. A HUGE thanks to the game for helping us out. I think it was totally worth it. I'll let the results speak for themselves!
Check out the entire Parents Play series here, as well as GoNintendo's other video content!
Kerbal Space Program is on its way to Wii U after already becoming a major success on PC. One would think that all is just great at Squad, the dev studio that created the game. If rumors are to be believed, that's not the case at all.
While the game is doing fantastically well and more success is on the way, it seems that multiple employees are unhappy with how the studio operates. Claims of wages amounting to $2,400 a year have come floating in. It's important to point out that the studio resides in Mexico, where minimum wage is $100 a month. That said, the studio employs numerous international devs and asks for 40 hours a week in work time.
We're also hearing that the studio is the latest in a long string of game creators that ask their employees to really hunker down on development, making for extremely long work hours and unfair amounts of time without rest.
Squad is yet to comment on this matter. If/when they do release a statement, we'll be sure to share it with you.
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16. Zelda: Ocarina of Time
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1. Star Fox Zero: The Battle Begins
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4. Pokken Tournament TV Spot
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6. Lost Reavers Trailer
7. Xenoblade Chronicles Trailer
8. Super Meat Boy Trailer
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10. Great Games to Buy with eShop Cards
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- coming from the official Japanese site
- news coming on May 10th 2016
- news due out 21:00 JST/8:00 EDT/05:00 PDT
First, there was Splatoon in Miitomo! Well now, there's Miitomo in Splatoon!
Our next Splatfest theme is brought to you by Miitomo! Would you rather go to fancy party or a costume party? Head to Inkopolis Plaza and cast your vote for the next Splatfest!
…and since it's a party, this Splatfest will be held simultaneously in all regions! For the first time ever, players in all regions will be matched up to play in Splatfast – and the results will be global.
The party starts 5/13 at 8 PM PT and ends at 3 AM PT on 5/15. When it's time to party we will party hard!


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Home > Australia > A-League > Melbourne Victory > Squad > Profile: Archie Thompson
Archie Thompson Melbourne Victory
Profile of the Australian footballer Archie Thompson, who currently plays as a forward at Melbourne Victory. The 37-year old player Thompson joined Melbourne from and wears the number 10 shirt.
Archie Thompson Career
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J�rgen Klopp hits back at his critics over Daniel Sturridge Europa snub
Ars�ne Wenger reveals he rejected Real, Barcelona and Manchester City
Manuel Pellegrini rails at league schedule before Real Madrid game
Crystal Palace�s Alan Pardew unable to escape spotlight on Newcastle return
Rafael Ben�tez wants Newcastle fans to focus on team, not Alan Pardew
Claudio Ranieri savours Leicester�s box office appeal but tells team to focus


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Most of us would be familiar with the old saying "The law is an ass".
Sadly, it seems New Zealand has another ruling that would tend to substantiate that.
Judge Graham Hubble presided over a case in which a top New Zealand sportswoman admitted driving with 801 micrograms per litre of breath - double the legal limit of 400mcg.
After hearing submissions from her defence counsel, the compassionate judge discharged her without conviction and gave her permanent name suppression.
Her lawyer, Marcia Insley, told the court that her client, who had no previous convictions, had reached an "exceptional level" in her sport, and had been offered a chance to compete overseas. A conviction would affect her ability to do that.
That was enough for Judge Hubble, who described Ms Insley's submission as "persuasive" as he agreed to her requests for a discharge and name suppression.
In explaining his reasons, he said he was mindful of occasions when New Zealand representative rugby players were refused entry to Canada because of similar convictions.
And there you have it.
The suppression order means the media cannot tell you who she is, the sport she's in or what she's achieved. The veracity of her lawyer's claims cannot be tested or verified.
Understandably, reaction has been quick. The sense of an open and transparent judicial system has once again been put at risk by what appears to be an overly generous ruling by a judge.
Perhaps the most galling aspect of his actions is that it appears to ignore the seriousness of the crime. The sportswoman was not marginally over the legal limit after consuming a drink or two too many. She was more than double the legal limit, which meant she was a danger to everyone else on the road that night.
That, in itself, should have ensured her lawyer's plea for leniency was unsuccessful.
Most fair-minded people are familiar with the legal principle of allowing for cases in which the gravity of the penalty would outweigh that of the crime itself. Fine, there will always be exceptions and judges should be allowed some leeway at such times.
This case, however, fails the commonsense test. Would the leniency have been extended to an All Black? If it had been, the one certainty is the uproar that greeted it would have been heard across the country - and rightly so.
The Government has spent a fortune on getting the message across that if you drink and drive "you're a bloody idiot". In this particular case it would appear that the ruling of the learned judge may well fit that description as well.
Hopefully, the Crown will seriously consider an appeal. This is something no top sportswoman, or sportsman, should ever expect to get away with.
Sport teaches them, above all else, that for every action, or inaction, there is a consequence. Sadly, it was missing in this instance.
- Taranaki Daily News
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CANNELTON - The Cannelton Community Foundation is looking for old and unusual pictures that depict community life in Cannelton.
Suggestions include pictures of working coal mines, building of the bridge, carving sandstone from the hills, crossing the frozen river and people enjoying community festivals. The group intends to make copies of these pictures for use at festivals.
If you have an interesting photo of early Cannelton to share, contact Christal Moskos at 547-4669.
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"Men are definitely more aware of how to look after their skin and appearance than they were even five years ago.
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Reasons to Not Be Ugly - *Season 5, Episode 28* This week, *Freakonomics Radio* takes a look at the "beauty premium" and, conversely, the downside of ugly. Do cuter babies get mo...
16 hours ago
Off topic for a moment... saw all of this weekend's Direct Air/Virgin America flights come in and out .... way toooooooooo cool!
Any word how the March loads are coming?
Harry T
Worcester, MA
Councilor Rosen asked this question last week and I don't think he got an answer.
Councilor Rosen, if you are out there can you answer?
haven't you heard..the CC does not read the blogs
8-10 Winfield and 224 Chandler Street are back to PIP like shelters..no city help...all main arteries swept..Chandler not..we are being left to rot in the urban core:>)


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Storage upstarts are tipping the vendor scales
The big storage vendors are always trying to steal a piece of each other's pie. But some small tech upstarts might play big parts in determining who comes out on top.
This Article Covers
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There's a delicate balance of power among storage vendors, but small tech upstarts might tip the scales. In the storage systems space, there have been only a handful of players -- EMC, Hitachi Data Systems (HDS) and IBM -- that have truly controlled the high-end enterprise array market. These vendors fight over billions of your dollars every year; much more than that if you count all of the ancillary stuff surrounding the hardware. If a vendor can get the "core," it can usually find other spots within the enterprise to sell the rest of its wares.
Steve Duplessie is the founder and senior analyst for the Enterprise Strategy Group in Milford, Mass.
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See related article in EMBO Molecular Medicine 10.1002/emmm.201202034
Testis specific gene expression drives disease progression and Rituximab resistance in lymphoma
Article first published online: 5 AUG 2013
DOI: 10.1002/emmm.201303018
Copyright © 2013 EMBO Molecular Medicine
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 8, pages 1149–1150, August 2013
Additional Information
How to Cite
Knapp, S. (2013), Testis specific gene expression drives disease progression and Rituximab resistance in lymphoma. EMBO Mol Med, 5: 1149–1150. doi: 10.1002/emmm.201303018
Publication History
- Issue published online: 5 AUG 2013
- Article first published online: 5 AUG 2013
- Abstract
- Article
- References
- Cited By
- BET proteins;
- bromodomains;
- Cyclon;
- Rituximab
Activation of cancer promoting genes or silencing of tumour suppressors is often due to aberrant expression of transcription factors or transcriptional regulators; interestingly, the expression of many of these transcriptional regulators is usually restricted to male germ cells (Rousseaux et al, 2013; Simpson et al, 2005).
The similarities between germ cell development and cancer have long been noted and resulted in the identification of a number of cancer/testis antigens such as the MAGE family members (Simpson et al, 2005). Although the biological function of many of the cancer/testis antigens is poorly understood, some are known to act as transcriptional regulators. These discoveries spawned the idea that aberrant expression of germ line genes in somatic cells triggers the activation of a gametogenic programme that drives tumourigenesis. A number of these testis/cancer genes comprise epigenetic regulators that play a key role in male genome reprogramming. BRDT, one such regulator, plays a critical function in spermatogenesis and acetylation-dependent chromatin remodelling (Gaucher et al, 2012). Indeed, germ cell and trophoblast differentiation shares many of the phenotypic hallmarks observed in cancer cells including immortalisation, tissue invasion, stimulation of cell migration, induction of angiogenesis and downregulation of the major histocompatibility complex resulting in immune evasion.
In this issue, Emadali et al (2013) report on the identification of the transcriptional regulator CYCLON (cytokine-induced protein with coiled-coil domain) as a downstream effector of oncogenic MYC signalling in lymphoma. CYCLON is highly expressed in testis but expression of this protein is also induced in a hematopoietic cell line by interleukin 3 (IL-3) (Hoshino & Fujii, 2007). The study revealed that in diffuse large B cell lymphoma (DLBCL), the most common form of B-cell non-Hodgkin lymphoma, over-expression of CYCLON mRNA correlated significantly with poor survival. Importantly, CYCLON over-expression was specifically associated with poor survival of lymphoma patients treated with the current standard-of-care chemotherapy CHOP (Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulphate (Oncovin) and Prednisone) in combination with the monoclonal therapeutic antibody Rituximab (Nastoupil et al, 2012) but not in patients treated with chemotherapy alone. This intriguing finding suggests that CYCLON expression confers resistance to Rituximab immunotherapy.
…CYCLON over-expression was specifically associated with poor survival of lymphoma patients treated with the current standard-of-care chemotherapy CHOP (Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulphate (Oncovin) and Prednisone) in combination with the monoclonal therapeutic antibody Rituximab…
The monoclonal antibody Rituximab (trade names Rituxan and MabThera) targets CD20, a surface protein mainly expressed in the B-cell lineage, leading to selective B-cell killing. The Rituximab + CHOP chemotherapy regime is a more efficient treatment strategy compared to chemotherapy alone in high-risk B-cell lymphoma (Michallet et al, 2012). Indeed, Rituximab in combination with CHOP achieves high response rates in B-cell non-Hodgkin lymphoma and has led to significant improvements in overall survival rates. A number of patients, however, develop refractory disease through a mechanism that is poorly understood (Cheson & Leonard, 2008). Studies that identify the mechanisms underlying Rituximab resistance and that lead to additional treatment options are therefore urgently needed.
CYCLON knock down in lymphoblastiod cell lines results in the modulation of transcription levels of a specific set of target genes. Interestingly, gene set enrichment analysis (GSEA) correlated with gene signatures of cancer testis antigens of the MAGE family and also matched expression profiles that are characteristic for aggressive subtypes of multiple myeloma. CYCLON knockdown also increased the sensitivity of lymphoma cells to Rituximab in vitro and in vivo. Importantly, the genetic knockdown effects were mimicked by the BET (bromo and extra terminal) bromodomain inhibitor JQ1 (Filippakopoulos et al, 2010) providing a rational for a new combination therapy in Rituximab resistant lymphoma (Fig 1).
The BET family member BRD4 plays an important role for survival of a number of diverse tumours due to its function promoting transcription of growth promoting and antiapoptotic genes. Dysfunction of BET proteins leads to development of aggressive tumours. For instance, genetic rearrangement resulting in "in frame" fusion of the N-terminal bromodomains of BRD4 and BRD3 with the protein NUT (nuclear protein in testis) give rise to the development of NUT midline carcinoma (NMC), an incurable uniformly fatal subtype of squamous carcinoma and in rare cases also cancers of other origins (French, 2012) providing another example of the strong tumour promoting effect caused by aberrant expression of testis specific proteins. One of the key functions of BRD4 in cancer is to regulate c-Myc expression (Delmore et al, 2011). Indeed, recently developed potent and specific BET inhibitors showed impressive anti-tumour efficacy in animal models and first clinical trials have been initiated recently (http://www.cancer.gov/drugdictionary?cdrid=733799). Since, however, oncogenic MYC is only one factor sensitising cancer cells to BET inhibition and considering its high expression levels in most tumours it is not likely that this oncogene will have predictive value for patient stratification. The study by Emadali et al (2013) makes therefore an important contribution by identifying the nuclear, male germ cell specific factor, CYCLON as a downstream effector of oncogenic MYC signalling in lymphoma. One of the open questions is now how MYC cooperates with CYCLON to give rise to changes in gene expression that lead to Rituximab resistance and disease progression. Further mechanistic studies are therefore needed to elucidate the molecular mechanisms of this regulatory gene expression network and to establish new therapeutic strategies for the treatment of Rituximab resistant lymphoma.
…makes therefore an important contribution by identifying the nuclear, male germ cell specific factor, CYCLON as a downstream effector of oncogenic MYC signalling in lymphoma.
The author declares that he has no conflict of interest.
- 2008) Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma. N Engl J Med 359: 613-626 , (
- 2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146: 904-917 , , , , , , , , , , et al (
- 2013) Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers. EMBO Mol Med 5: 1149-1150 , , , , , , , , , et al (
- 2010) Selective inhibition of BET bromodomains. Nature 468: 1067-1073 , , , , , , , , , , et al (
- 2012) Pathogenesis of NUT midline carcinoma. Annu Rev Pathol 7: 247-265 (
- 2012) Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J 31: 3809-3820 , , , , , , , , , , et al (
- 2007) Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. FEBS Lett 581: 975-980 , (
- 2012) Maintenance therapy in diffuse large B-cell lymphoma. Curr Opin Oncol 24: 461-465 , , (
- 2012) Diffuse large B-cell lymphoma: current treatment approaches. Oncology (Williston Park) 26: 488-495 , , (
- 2013) Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers. Sci Transl Med 5: 186ra166 , , , , , , , , , , et al (
- 2005) Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5: 615-625. , , , , (


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New York, NYUSA
November 6, 2012
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Hi! I am a salsa dancer and just love the flash mob concept so I think it would be great to join this group and watch dance spontaneously improve the mood of the world! :)
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Native Plants
Q. Who is Mr. Smarty Plants?
A: There are those who suspect Wildflower Center volunteers are the culpable and capable culprits. Yet, others think staff members play some, albeit small, role. You can torture us with your plant questions, but we will never reveal the Green Guru's secret identity.
Did you know you can access the Native Plant Information Network with your web-enabled smartphone?
Ask Mr. Smarty Plants is a free service provided by the staff and volunteers at the Lady Bird Johnson Wildflower Center.
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Wednesday - April 04, 2007
From: Austin, TX
Region: Southwest
Topic: Trees
Title: Spring blooming Acacia farnsiana in Austin
Answered by: Jimmy Mills
QUESTION:I've been seeing a large shrub, possibly tree, around Austin this spring - and it is covered is small ball-like orangish-yellow blooms - very tightly covered in these blooms. From the car, it looks sort of like a retama type form, but smaller leafed and a tighter, thicker growth habit. Is it somethingi native or an invasive species. I've seen it at the hike and bike trail and just around town.
The plant you are seeing is Huisache Acacia farnesiana (sweet acacia), a member of the pea family (Fabaceae) which is distributed in the US across the contiguous southern states from Florida to California, and into Mexico. It is described as a tree/ shrub growing to 15-20 feet.
The Retama, Parkinsonia aculeata (Jerusalem thorn), that you mention is also a member of the pea family with yellow flowers, but as you can see from the pictures, the structure of the flowers and stems is different.
From the Image Gallery
More Trees Questions
Need suggestions for plants for a privacy screen for a pecan orchard in Chappell Hill, TX.
September 21, 2011 - Mr. Smarty Plants, My family has just begun converting our land in Chappell Hill, TX (Washington County) into a pecan orchard. We had to clear a lot of the overgrowth around the edge of the proper...
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Trees for privacy screen
August 08, 2012 - Hello, We'd like to plant a privacy screen to hide our view of an adjacent apartment complex. Ideally the trees or other plantings might be a native species, and preferably they would eventually rea...
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February 23, 2013 - DO I need to worry about Fan TX roots being a problem near house foundations?
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What is the pH of Bald Cypress needles?
February 24, 2010 - What is the pH of Bald Cypress needles?
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Killing regrowing shoots of a downed hackberry tree
June 28, 2013 - Hackberry plants won't die. You and others have suggested to cut the suckers or saplings to get rid of them. Over the years I have continued to cut the same saplings and the only thing I have now ar...
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Feb 27, 2013, 08.45 AM | Source: CNBC-TV18
On February 26, 2013 CLSA (Mauritius) Limited sold 2,627,119 shares of Essar Shipping at Rs 21.25 on the NSE.
However, Leman Diversified Fund bought 2,627,119 shares at Rs 21.25.
In the previous trading session, the share closed at Rs 21, down Rs 1.45, or 6.46%. It has touched a 52-week low of Rs 20.65.
The share touched its 52-week high Rs 35.40 on 07 August, 2012 and currently, it is trading 40.68% below its 52-week high. Market capitalisation stands at Rs 430.98 crore.
There are positive opportunities that could arise
After the scheme of arrangement, Essar Shipping is
Essar Shipping is all set to list on the exchanges
Prakash Diwan, Asit C Mehta Investment shares his
SP Tulsian on sptulsian.com in an interview to CNB
SP Tulsian, sptulsian.com is negative on Essar Shi
The explosion took place while a diving bailout bo
Shipping Corporation of India Ltd has informed BSE


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Not Sturdy! Nice looking bench but not strong. The legs are shaky and unstable. The colors on the picture are not true, did not have much pink more orange. Disappointed.
very decorative bench (do not sit on it)
Really pretty to include the look of the wood. Be aware the color's are MUCH brighter than pictured so if you buy this color you better like orange. the wood is beautiful looking and not sure what type of wood this is. Here is what I learned; I bought a console table made of "rubber tree wood" and though its stunning, its VERY soft and will easily scratch deep. This wood appears to be the same. For me the look of it is a favorite, but it your dog for example jumps up on the arm, expect a deep scratch. Its really, really soft wood, but again really nice looking.. I bought some wood filler markers to hide the scratches. your thumbnail will easily put a deep scratch in it. Not recommend for a little kids room. I still love the piece, its nice looking.
The bench looks very nice but is not practical for frequent use. The frame is not designed correctly as it will lean laterally with the smallest load. I used wood glue on the frame along with the two (2) wood screws...still flimsy.
I choose this stool because of its beautiful design; however, build quality is poor. The wood joints have large gaps that will not close no matter how tight the provided screws are installed. This makes for a very loose fit of the side arms and leg end pieces that may actually result in the stool coming apart if a person sits on it. Needs several bracing brackets to make it sturdy enough to sit on it.


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20 Creative "Out of the Carton"...
20 Egg-cellent Egg Dying Ideas for Easter
4 Winter DIY Projects to Try Out With Your Kids
Baby it's cold outside! Stay in and try out these adorable winter DIY projects.
Mastering the Art of Brushed-On Finishes for...
If you're a fan of the classic look, brushed-on cabinet finishes have a lot going for them.
Scroll For More


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If you want info on properties WITHIN the city of EC, use this site: http://www.bis-net.net/cityofeauclaire/search.cfm.
If you need help with anything else, feel free to contact me at 715-577-0028. I was born and raised in Eau Claire and know this area well. Good luck in your home search!
Wendy Boulden
REMAX Affiliates
http://www.co.eau-claire.wi.us is the site I use.
If you are buying a home through a realtor, you should find one that is ABR certified.
Those agents have advanced training to represent buyers and have received the ABR designation.
ABR - Accredited Buyers Representative. Only those that have taken the extra training can put
ABR behind their name.
A buyers representative works in your best interest, they can look up the assessor information, etc for you so you can make and informed decision before you put your offer in.
If you are working with a realtor you may want to ask them about Buyer Agency. If you would like to work with a Buyers Agent to help find you a home you may contact me. I am ABR Certified.
Debbie Bertelson, ABR, SRES
Century 21 Premier Group
See ALL listings the second they hit the market at: http://JustListed.ranww.mlxchange.com
You can find Eau Claire county tax information at http://bis-net.net/ECCounty/search.cfm. The city of Eau Claire tax information can be found at http://bis-net.net/cityofeauclaire/search.cfm. These are free access.
Good luck on your home search.
Emmanuel J. Scanlan
PS Inspection & Property Services LLC
214-418-4366 (cell)
TREC License # 7593
International Code Council, Residential Combination Inspector #5247015-R5 (Electrical, Mechanical, Plumbing and Building)
Certified Infrared Thermographer (ASNT-TC1A Standards)
Texas Residential Construction Commission, Third Party Warranty Inspector #1593
Texas Residential Construction Commission, Inspector, County Inspection Program
Texas Department Of Insurance, VIP Inspector # 08507061016
Hayman Residential Engineering Services, Field Technician
CMC Energy - Certified Energy Auditor
Knowledge is power, but sharing knowledge brings peace!!
I there is any other issues that you would like help with I would be happy to help you navigate through thesites. I am a life long resident of the Eau Claire area.
Thank you,
Jean Barlow
ERA American Realty Group
Cell 71-577-142
You can use that site for free. There is a paid version which I am a subscriber. Do you need something specific?
In my area of Adams County Wisconsin, the free website is http://www.adamscountylandrecords.com .


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Animals & Pets Christmas Ornaments
The perfect gift for any animal lover, these glass animal ornaments range from traditional to more exotic pets, and even include wild animal ornaments. We offer different breeds of dog ornaments and an array of colorful fish and bird ornaments. Find the glass ornament that perfectly fits your pet.
- Home
- →
- Glass Ornaments
- -
- Animals & Pets
- Alligator Price: $14.95
- Aloha Fish (Pink with Sequins) Price: $15.95 Discounted 20%: $12.76
- Aloha Fish (Pink, Green) Price: $15.95 Discounted 20%: $12.76
- Arctic Owl Price: $12.95
- Arctic White Snowy Owl Price: $21.95
- Bald Eagle Price: $17.99
- Barn Owl Price: $15.95
- Basset Hound wearing a Hat Price: $15.95 Discounted 20%: $12.76
- Beagle with Pink Feather Price: $15.95 Discounted 20%: $12.76
- Bee Cutie Price: $12.99
- Bee on Flower Price: $30.99
- Bernese Mountain Dog Puppy Figure Price: $24.00
- Bichon Frise Puppy Figure Price: $24.00
- Big Foot Price: $14.95
- Blue Noah's Ark Price: $14.99
Read what our customers say about our Personalized Christmas Ornaments and their shopping experience!Hover over testimonials to stop scrolling
11/13/2015 - "Love this store I buy an ornament from here every year. Leasa M."
11/16/2015 - "Nice shop. Lots of choices. Debbie S."
11/11/2015 - "Always a pleasure to shop Ornament Shop for Christmas ornaments - Items are excellent - Everyone looks forward to receiving them - Love the free shipping. Gladys S."
11/23/2015 - "The "grandma's first Christmas" ornament was exactly as advertised. The personalization was perfect and I can't wait to give it to my friend. This will be her first Christmas as a grandmother, so the ornament will be an excellent keepsake for her. I was going to wait until Christmas to give it to her , but I don't think I can! Kay H."
3/3/2016 - "Workmanship was of a good quality.Kathleen S."
4/10/2016 - "Dear Dianne Absolutely first rate customer service! All five ornaments arrived, packaged extremely well, much faster than I could have imagined, taking the time into consideration of personalizing each ornament. I buy ornaments every Xmas for my 8 grandchildren. Some of them have 26 ornaments (one for each year of life)?? I have purchased some very expensive ornaments in the past years, especially for my older grandchildren. I am soooo pleased with your ornaments, at a much lower price than I have paid previously. I will be online again next year Sincerely, Agnes B."
11/28/2015 - "Have bought ornaments annually for my kids here for years. Would love more teenager items. Would also like more than one hair color option on all items. Charles W."
12/7/2015 - "Happy! Dona H."
11/21/2015 - "I have ordered many times! I love everything about the company and product! Anonymous Respondent"
12/10/2015 - "Was very happy to find these items as ornaments. Nancy J."


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The Style Gallery is a great new way for you to view, love, and share outfit photos. It's meant to showcase
all the expressive, creative, and inspirational personalities of our community!
North a Thousand Words Rug
Ocean Sesame! Bottle Opener
Simple Twist of Inflate Pool Float
Reef Your Worries at the Door Rug
Mermaid for Each Other Bookends
Take It or Reef It Notebook
Put the Gears in Ocean Mug
Put the Gears in Ocean Travel Bottle
Whaled It! Measuring Cups
Deep Tea Diver Infuser
Whale-Balanced Breakfast Mug
Whale-Balanced Meal Spoon Rest Set
1 left!
Maritime and Tide Duvet Cover in Full/Queen
Just My Cup of Sea Mug and Tea Infuser Set
Aweigh From It All Tea Towel Set in Deep Sea
Try as I Light Lantern in Midnight
Ship by Sip Mug
I'll Be Sea-ing You Light
Pacific Pairing Pillow
Out of Stock!
Beauty Beyond Treasure Jewelry Box
Fret Knot! Keychain
Ready in Dive Minutes Bowl
Expert Explorer Water Bottle
Mast Call Tray Set
Swell Sea-soned Measuring Cups
Cast a Shell Wall Decor
Swell Sea-soned Bowl Set
Whale, What Do We Have Here? Mug
Aweigh From It All Coaster Set
Aweigh From It All Tea Towel Set in Coral Reef
Cast a Wide Nettle Rug
Ocean and Wishin' Tapestry
Aweigh From It All Plate Set
Reef Introduction Pillow
Sea Life of the Party String Lights
Nautical Chic
Posterior Design Magnet Set in Whales
Aweigh to Go Mug Set
Aweigh to Go Bowl Set
Oceanic Artistry Coloring Book
Ahoy Meets World Apron
Contrary to Popular Reef Pillow
You Octo Glow Lamp
Swell Acquainted Shower Curtain
Welcome With Ocean Arms Spoon Rest
Whales in Comparison Butter Dish
Tie Maintenance Mug
Wherever You Arm Shot Glass
Anchor the Call Mug
Ink Black Coffee Mug
Mermaids: The Myths, Legends, & Lore
The Art of Nature Coloring Book
Back Today!
Pour Overboard Mug
Ahoy, Bathing! Shower Curtain
For the Fin of It Shaker Set
Oh, The Places You'll Glow Lamp


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This is a telecommuting position with frequent travel to company HQ in Sunrise, Florida or can be based full-time in our Florida HQ. You've love words....
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You will receive three weeks of annual paid vacation and have the additional option of telecommuting – working from home or remotely from any location in the...
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You will receive 17 days of annual paid vacation and may be eligible for telecommuting – working from home or remotely from any location in the world – for a...
ATG Technical Lead Location: Dallas, TX Amplifi Commerce is seeking ATG Technical Leads to join our solutions delivery team in Dallas, TX. Our company and...
Feb 5 - United States
Telecommuting opportunities available in the Mid-Atlantic region. To develop and implement successful fundraising strategies for soliciting individual PETA...
Jan 21 - United States
Cash Advance - Account Manager - Customer Service
FlashBanc is an industry leader providing alternative financing solutions/business loans for various businesses throughout the country. You will be responsible for developing relationships within your local community, while providing an excellent way for merchants to have access to working capital. This is done in a cash flow friendly way through daily remittances. An ideal candidate is an ...
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To develop a Collaborative environment for editing, creating, and publishing new medical terminology, and to standardize medical terminology across domains
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Web Designer / Front-end Developer
Web (Graphic) Designer / Front-End Developer:Key Responsibilities:Initial primary role would be design and code out including creating and prepping specific imagery, banners and website designs. Other responsibilities would include adding styles, content formatting, jQuery snippets, HTML5 & CSS3 code out.Must be able to take a project from start to completion with proper art direction.Must ...
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Digital Content Startegist
Position: Digital Content StrategistThe Digital Content Strategist will be responsible for both writing and editing content for best SEO and conversion results. He/she should be a self-starter that wants to contribute and capitalize on their SEO content writing skills. Knowledge of SEO Best Practices is a must.This position will not only help to produce content, but mostly assist in ...
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Software Trainer
Are you a tech-savvy person who likes helping others? Do you have a passion for productivity? Do you want a part-time job working from home? If so, you could be the perfect fit for this role.As a software trainer, you'll work one-on-one with professionals, teaching them a series of best practices for their digital tools that will dramatically increase their organization and productivity. You ...
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Miami - IT & software
Endeca Architect Locations: Dallas, TX (Preferred) or Remote Amplifi Commerce is seeking an experienced Endeca Architect to join our team. Our company and...
Application Developer (Telecommute)
Telecommute is an option.Looking for someone who can take an idea and run with it. We'll be looping them in on the wireframing and designs giving them the ability to help shape the mobile experience. The developer (Mid level or better) will be responsible for developing the iOS/Android APP (likely with PhoneGap or Cordova) and maintaining that side of the product. Should be reliable and able ...
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Welcome to one of the toughest and most fulfilling ways to help people, including yourself. We offer the latest tools, most intensive training program in the
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TESS Training is a full service personnel development consulting firm that provides services to the oil and gas industry. We analyze process, operations, and maintenance activities, identify key efficiency and existential problems and provide the solutions to resolve them. We also offer training solutions to bring personnel and management teams into full competency.As a Technical Sales ...
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Miami - Sales & biz dev
This is an on-site, in-office position – telecommuting is not an option. StudioPMG is building an intelligent and talented team of business professionals for...
Sales Representative (Event Sponsorship Executive)
The right staff is integral to the winning strategy that MSE Partners executes every day, which is why we strive to attract the best the industry has to offer. As a young organization that produces and sells our own executive events in addition to our consulting services, we offer the opportunity to fulfill a variety of career desires. We are currently looking for a select few additional ...
The position involves telecommuting from a home-based virtual office. Including the POSITION ID NUMBER in your email, response is CRITICAL to the successful...
Apr 19 - United States
Sales Representative Needed Immediately (telecommute)
Thinking about a sales career? We are interviewing! This position does not require prior sales experience, but does require a track record of completing tasks in a timely manner and working in a fast-paced environment.Due to sustained market growth over the past 5 years and new product launch, we are expanding our sales team and are interviewing for sales representatives this week and next. ...
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Hollywood - Sales & biz dev
This is a fulltime telecommuting position so it is ideal for a self-starter who can work independently of others but also contribute as a member of a team....
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Virtual Telesales - Wireless Distribution
Provide wireless dealers and consumers the opportunity to purchase wireless discounted products at 50-75% below retail price. This is a great service for independent dealers and customers on prepaid accounts. You will be responsible for cold calling dealers, advertising online and begin marketing the current lists of products available. All latest, trending units are available along with ...
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This is a fulltime telecommuting position so it is ideal for a self-starter who can work independently of others....
There has never been a better time to think about your new career. The economy is improving and the 2013 Boat Buying Season is upon us. Boat and yacht buying is alive and well. Boats and ...
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Preferred location is either our Los Angeles, CA or Watkins Glen, NY office, but candidates interested in telecommuting from a remote home office will be...
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Hair Care Brand looking for Agents in Vietnam
We are seeking agents to
become representatives of an
American brand in Vietnam.
We are a well established
hair care product line that
offers quality products at the
best prices and now is a
great opportunity to set up
as a representative as we are
ready to enter that market. If
you have friends or family
members that live in
Vietnam or the surrounding
areas please ...
Apr 28 -
Miami - Sales & biz dev
Call Center - Work Study for Accelerated College Degree Program
Two positions available - seeking applicants with call center, teaching, and tutoring backgrounds.Teacher Assistant positions available – part-time and short term – work from home (virtual classes) or at a campusInstructor positions available – part-time and long term - work from home (virtual classes) or at a campusPlease see detailed descriptions of these open positions at bottom of this ...
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SEO Help (simple task)
I'm looking to get a verified google listing within the state of Florida.
In order to get verified, I need a postcard sent to a physical address within that state.
I don't have a physical address in that state.
So all I am looking for is someone to help me out, and simply receive a postcard that will have a verification code on it - and all you have to do is send it to me.
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Entry Level Trader: Banking, Finance, Data, Analyst - Work Remotely
Maverick FX is a proprietary trading firm focused on Forex currency trading. We are searching for motivated and teachable candidates to trade the Forex market on behalf of the firm. Forex trading is a great career as it offers flexible hours, a challenging profession, unlimited potential and the ability to trade from anywhere in the world via high-speed Internet. ------- ABOUT MAVERICK FX --- ...
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SharePoint Developer
Hi, We have a requirement for a SharePoint Developer from our client, a government agency in Miami, FL.Please note that this position is a C2C type onlyWe would prefer candidates LOCAL TO FLORIDA for this position.Rate is negotiable. Job Description: Start Date: ASAPEstimated Duration: 10 months with possible extensionType: Temporary ProjectRemote or Onsite: On location at the Client's site ...
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Social Media Strategist
Social Media StrategistKey Responsibilities:Manage and run all social media paid efforts (largest emphasis is on Facebook)Manage the social media presence and maintain all channels for over 15 clients (Facebook, Twitter, YouTube & G+)Continually grow and engage with social media audiences and followersReview and analyze social media channels, identifying areas for improvement and change. ...
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West Palm Beach - Marketing & PR
ROBERT CHRISTOPHER YACHT SALES, is one of the oldest and most successful pure yacht brokerages in America. Established in 1975, this year we will celebrate 40 years of serving our boating friends and families here in America and Internationally. We now have brokers in seventeen states and three countries and we look forward to our further expansion.
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Boca Raton - Sales & biz dev
Jan 20 - United States
Multiple Locations (Some telecommuting possible) Opportunity Type :. Sr....
Apr 7 - United States
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Contact Solutions offers a competitive salary and benefits package, including employer-paid medical, dental, life and disability benefits, generous 401(k) match...
May 3 - United States
Telecommuting may be an option for this position. Covenant Eyes provides first class Internet Accountability and Filtering software....
Mar 23 - United States
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Neighbors' Day: April 30
To mark the first anniversary of the Whitney's new home, neighbors visit free on Saturday, April 30.Reserve tickets
My name is Erin, and I am a senior in high school. I was born in New York City, and I have lived in Queen my entire life. My major in high school is visual art. I love to work with photography and mixed media because they let me create a variety of visual representations of my emotions.
I joined Youth Insights because I love to learn about new and contemporary artists. The program also interested me because I really like analyzing and having discussions about different works of art.
I've been inspired by quite a few artists, one of them being Barbara Kruger, whom I was able to meet at the Museum. Also, I love the Surrealist paintings of Dalí, as well as the warped elastic lens photographs of Weegee. I've noticed that these artists were way before their time, and they brought new meaning to twentieth century art. Their work shows amazing originality.
I am planning to continue studying art in college, and I hope to someday build a career around my passion for artistic expression.


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Vocabulary Word
Word: perceptive
Definition: insightful; showing a good ability at perceiving and understanding; aware; wise; of perception
Definition: insightful; showing a good ability at perceiving and understanding; aware; wise; of perception
Sentences Containing 'perceptive'
"Meeting Joe Strummer" is a perceptive, funny and hard-hitting play about male friendship, integrity and the struggle to retain youthful idealism in the face of life's bitter blows, which was an Edinburgh Festival Fringe First winner in 2006.
The Prize committee citation described the play as "a powerful work whose memorable characters speak in witty and perceptive ways to America's sometimes toxic struggle with race and class consciousness."
The American critic Roger Ebert later wrote that it was perceptive look at identity, alienation, and the human desire to escape oneself.
Ebert later changed his opinion about the film, writing that it was a perceptive look at identity, alienation, and the human desire to escape oneself.
Her writing has appeared in "National Geographic Traveler" and Perceptive Travel.
An energetic and perceptive ruler, Mustafa III sought to modernize the army and the internal state machinery to bring his empire in line with the Powers of Europe.
When the Kings are clear and perceptive with regard to Heaven and Earth, the gods will make evident their blessings.
"Q" likewise gave it four stars and said that Mann has "returned to writing songs which are wry, funny, adult and perceptive, all wrapped up in handsome melodies."
Being excited by American film-noir and as a perceptive viewer of all films, accustomed to think in large terms and always urged on by new movements in the artistic world, he wanted to establish himself with his own impulses as a director beyond the limited framework of the "small box".
It howls and stammers, but it also sings...Inarticulate and emotionally shut down, her massive body at once a prison and a hiding place, Precious is also perceptive and shrewd, possessed of talents visible only to those who bother to look.
More Vocab Words::: enact - make (a bill) into law
::: miscreant - wretch; wrongdoer; villain; Ex. kindness to the miscreant; CF. believe
::: missile - object to be thrown or projected
::: blight - plant disease; V: infect with blight; ruin; destroy
::: perpetual - everlasting
::: malfeasance - wrongdoing; misconduct (by a public official)
::: fetter - shackle; restrict the freedom of; N. chain or shackle for the foot of a prisoner; CF. foot
::: implausible - unlikely (to be true); unbelievable; Ex. implausible alibi
::: jetsam - things thrown from a ship (to lighten the ship)
::: protract - prolong; lengthen in time; draw out


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The outgoing head of the IDF's computers and communications branch outlines the army's approach to cyber warfare and dealing with Hamas and Hezbollah in future confrontations.09:12 30.04.16 | 0 comments
What you don't understand, Mike, is that the Palistinians NEVER have peaceful protests. And as for not affecting Jewish holy sites, The Temple Mount is THE holy site, not the Western Wall. That was the retaining wall for the Temple. The Jewish Holy of Holies is ON the Temple Mount, where the Temple stood.


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I agree - AAOI seems to be poised for significant growth over the next few years. This "hiccup" is typical of any business in the transition phase where older products are slipping a bit and the newer stuff has not yet ramped in a big way. The marker makers are doing their usual dirty work, knocking the price down with the endless 100-share head fake trades. Hard to ever call an absolute bottom for that reason - they can ALWAYS generate another 100 shares at an artificially low price, or some sucker sets a stop loss so low the MM's can't resist walking the price down to capture it.
Regardless, given the price destruction over the past couple of weeks and the future looking extremely bright it seems a great entry point here. Very cheap on most standard measurements - PE, price-to-sales, price-to-book. Chart shows it rebounds quite rapidly when the reversal occurs and there have been only a few weeks out of the 2 years of public trading the stock has been this cheap. I've been buying on every successive dip and look to hold for a couple of years as the 100G transition really kicks in.
The call will clarify the reasons for the quarterly "miss" and my bet is the guidance for next Q should be decent and getting better with each quarter the rest of this year and beyond.
Sentiment: Strong Buy
Just reviewed the corporate presentation again (page 9 of the presentation on the website, in the Investor Relations section, presentation dated 3/7/2016). It's pretty clear that 2016 is expected to be a fairly modest year for 100G products and the company is smack in the middle of the transition. No big surprise that margins are a bit down since they are selling legacy stuff and the initial wave of 100G demand has not really kicked in yet. But looking ahead to 2019, 100G is projected to dominate with 40G virtually disappearing. Analysts (always taken with a grain of salt but nonetheless the market seems to value their opinon) are calling for earnings in 2017 of $1.61 per share. Slap a PE of 20 on that and it's a $32 stock. What about 2019 when 100G is running everything? Buy and hold - this has the potential to be a monster gainer over the next few years - forget the quarterly madness.
I don't think much happened except the same stuff that happens to ANY company when the market is obsessed with quarterly performance. Name a single company in the history of the world that has not "missed" a quarter. Product lines change, transitions occur, lots of stuff happens all the time to real companies in the real world that make the precious analysts wrong with their precious models all the time.
When these big selling waves begin they kind of take on their own momentum, and the market makers gladly help out by plunging the ask to shake out as many suckers as possible. Shorts smell blood and pile on to make a few bucks. NASDAQ is entirely a market maker based system and all shares are coming from a market maker somewhere. It is ALWAYS in their best interest to buy inventory as cheaply as possible so they do everything they can to walk the price down, pick up cheap stop losses etc. These big plunges tend to drive margin call selling as well - it happens all the time, over and over again. This is just another classic example of the same pattern repeating itself. Hard to ever call the exact bottom but usually buying a quality stock after one of these crazed short-sighted sellloffs has been a pretty good move. The company has stated they expect the transition to 100G and DOCSIS 3.1 to begin in earnest later this year so picking up a position here and holding should be a good move with any patience. It may still drift lower since a lot of buying interest will probably be on hold until the call gives more clarity but I bought yesterday and today and plan to hold for a couple of years. 100G is clearly the next big upgrade cycle for data centers as is DOCSIS 3.1 for cable operators. AAOI is very well positioned to ride the wave - what's happening this quarter is largely irrelevant except as a trading point. Look at the chart - the stock has only been this cheap for a few weeks in late '14 early '15.
Sentiment: Buy
Given the nature of market makers and their ability to manipulate prices I would say some level of downside risk remains but it does seem an overall favorable entry point. If the 100G cycle and DOCSIS 3.1 seriously gain traction this year the stock could double from here into 2017. Could be a 3-year upgrade cycle underway - the call will reveal a lot. In the meanwhile the MM's will do their thing to get prices as cheaply as they can so don't be surprised to see a few more down days as they continue to fish for stop losses and generally try to walk the stock down.


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